 snowboards over the gas guzzler being peddled.
I propose that this will be my last slasher review. May I end on a bit of a digression? That glorious year, 1981, was for slashers what 1967 was for the counter-culture—a brief moment where a little bit of magic happened that irked the mainstream. How beautiful those goofy Halloween imitations look, with their porno-style lighting and synthesizer soundtracks. Their twenty and thirty-something actors attempting to look like teenagers. Their mad rush to execute the most gruesome special effects their low budgets could afford. It can never happen again. I recently watched Hatchet, which had been touted as a return to the old-style slashers. No way. Didn’t even come close. The golden age of slashers was a flash of inspired stupidity that rests in the wounds of nostalgia. There is no way to recreate, remake, or, for shit’s sake, “reboot,” them. Let’s accept the handful of originals as they are and find new ways to make our collective master angry by harming our rented bodies.
Posted by Jimmy Callaway at 3:49 PM No comments:
Friday, July 8, 2011
Basket Case (1982)
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Posted by Jimmy Callaway at 5:12 PM 2 comments:
Wednesday, June 1, 2011
Graduation Day (1981)
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Posted by Jimmy Callaway at 8:07 PM 3 comments:
Monday, May 2, 2011
The Burning (1981)
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Posted by Jimmy Callaway at 3:28 PM 3 comments:
Wednesday, April 6, 2011
Halloween (1978)
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Posted by Jimmy Callaway at 1:48 PM 3 comments:
I believe Eagle was referring to the dubious wisdom of embracing the dark with the Dark Lord.
I’m going to have to think up some good recipes to grill over that sucker...Ring Wraith Sliders, Smeagol’s Burnt Ends.
One of the benefits of using DE razor blades is they are cheap. I get 100 for $12 at West Coast Shaving. A blade lasts about a week. For the last couple of years I’ve been using Crystal blades. So one of the bad things about using DE blades is that a supply lasts so long that you only get that “change of blades thrill” once every couple of years. No instant gratification! I just got my 2020/2021 order and am trying Israeli Personna. Even though I still have enough Crystals to get me to Christmas, I slipped a Personna into the razor this morning. It was a little sharper and smoother. I hear they last well. We’ll see. Anyway, at least for today they are one of life’s minor luxuries.
At this moment, 3:30AM, I am not enjoying one of my most beloved minor luxuries and that is sleeping through the entire night. Lots of little things running through my head (work), that needed to ne noted, thirsty (forgot my bedside bottle of Perrier).
Further to my post last Saturday, I’ve been using the same blade a week now. It is shaving extremely close and at least as smooth, if not smoother! I’m a fan. Of course all brands, even the pricier ones, have some variation in sharpness and smoothness, but my first Israeli Personna is a total success.
Today I retired the above described Israeli Personna. It actually was shaving quite close and with reasonable comfort, but I figured that razor blade sellers need to make a living too. At $14 for 100 and two weeks per blade my math skills tell me this was a good purchase. BTW I’m now using my last three Feather blades. They cost more and don’t last more than a few days but wow are they sharp!26th March 2012:
The P2P Finance Association, the trade body representing leading UK peer-to-peer (P2P) financial businesses, has today welcomed Government approval of the Association’s Rules and Operating Principles. These Principles, which Association members have to adhere to, set out key requirements to ensure transparent, fair, robust and orderly operation of their platforms to protect both savers and borrowers.
The Department for Business, Innovation & Skills, when responding to the recent ‘non-bank lending taskforce’ report by Tim Breedon, backed the establishment of a P2P industry code as a means to raise awareness of P2P finance, but also safeguard usersi. Giles Andrews, Chair of the P2P Finance Association said: ‘This is a hugely exciting sector, and one that has experienced significant growth over recent years.
The P2P Finance Association has established strict operating principles to ensure a level of uniformity amongst members which in turn will reassure and protect our users. We are delighted that the Government has endorsed the development of our industry body and code of practice’.BR6 is a postcode area nestled in the north of Kent close to South London. It takes in the beautiful villages of Downe, Pratts Bottom, Farnborough and Chelsfield, along with the areas of Green St Green, Locksbottom and Orpington. With an approximate population of 135k, there are good transport links from two stations within the BR6 area and you can be in central London within 18 minutes making it a very comfortable commuter belt.
The BR6 area hosts a number of bars, pubs and restaurants, along with a vast array of delightful coffee shops and tea rooms, offering delicious dishes and cakes. BR6 also provides us with many salons, florists and boutiques offering their unique niche products. There are a wide choice of sports clubs, stables, golf courses and wellbeing classes that are also available within the area. We are always discovering, exploring and experiencing new places along our journeys, and we will continue to share these on BR6Life as we find them.
Fancy getting in touch with us, send us any questions, suggestions or ideas. We are always happy to hear from you so please email us at |||EMAIL_ADDRESS||| BR6Life is all about showcasing local businesses in and around the BR6 postcode area. We are so fortunate in our area to have so many successful independent businesses, which create local job opportunities which bring us the community spirit. Therefore it is important we carry on supporting them in every way we can.
If there’s something you’d like to hear about then do let us know.Anti-inflammatory effects of mesenchymal stem cell-conditioned media inhibited macrophages activation in vitro

The immunomodulatory effects of mesenchymal stem cells (MSCs) on macrophages have been reported, however, the underlying mechanism remains unknown. Therefore, this study aimed to investigate the anti-inflammatory effects of MSCs on lipopolysaccharide (LPS)-stimulated macrophages and the subsequent downregulation of their inflammatory mediators. Macrophages were treated with conditioned media from MSCs, without a subsequent change of MSCs responding to the inflammation state. This study also evaluated whether the interleukin (IL) 4 stimulation of MSCs can improve their anti-inflammatory effects. Results demonstrated that the MSC-conditioned medium (MSC-CM) stimulated with IL4 significantly inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression of LPS-activated macrophages. MSC-CM treatment inhibited the mRNA transcription of the cytokines IL1β and IL6, the chemokines C–C motif ligand (CCL) 2, CCL3, CCL4, and CCL5, and the chemokine receptors CCR2 and CCR5, in LPS-stimulated macrophages. As revealed through western blot and immunofluorescence analyses, the phosphorylation of p38, JNK, and ERK MAPKs, as well as phosphorylation of NF-κB in stimulated macrophages, were also inhibited by the MSC-CM. Further, more potent anti-inflammatory effects were observed with the IL4-stimulated cells, compared with those observed with the non-stimulated cells. The MSC-CM demonstrated a potent anti-inflammatory effect on LPS-activated macrophages, while the IL4 stimulation improved this effect. These findings indicate that MSCs could exert anti-inflammatory effects on macrophages, and may be considered as a therapeutic agent in inflammation treatment.

Inflammation is a protective response mediated by immune cells and molecular mediators toward invasive pathogens that cause infection and tissue damage. However, inflammation is also related to many pathophysiological processes 1. Some diseases, such as osteoarthritis (OA) 2, rheumatoid arthritis 3, inflammatory bowel disease 4, diabetes 5, and acute lung injury 6 have been reported to be related to inflammation induced by immune cells and molecular mediators.
The use of stem cells might offer the most promising cell therapy strategy for the biological treatment of inflammation [15][16][17]. Mesenchymal stem cells (MSCs) currently represent an important immunotherapeutic cell group, and there are several possible applications of MSCs in the treatment of immune function-related diseases [18][19][20]. The regulatory network of the factors inducing the generation of the regulatory immune cells is a characteristic of MSCs participating in immune homeostasis, making them conducive for immunomodulation [21][22][23]. MSCs are circumstance-sensitive cells, as they respond to extracellular stimuli by inducing various interventions that are specifically sensitive to alterations in signals 24,25. Upon exposure to proinflammatory factors, MSC-mediated immunomodulation is upgraded 17,26.
MSC-conditioned media (MSC-CM) refer to the supernatants of an MSC culture, containing various cytokines and extracellular vesicles secreted by MSCs which can regulate the immune response 27,28. Takafuji et al. revealed that a conditioned medium from cultured MSCs downregulated the expression of tumor necrosis factor (TNF)-α and interleukin (IL) 6 in macrophages by suppressing the mitogen-