Nightwing11 commited on
Commit
ca6f751
·
1 Parent(s): 36215f6

Using abosulute path to save the newly fetched transcript

Browse files
Data/yt_transcript.py CHANGED
@@ -6,16 +6,25 @@ from datetime import datetime
6
 
7
  transcripts = []
8
 
 
 
 
 
 
 
 
 
 
 
 
9
 
10
- def save_transcript(video_id, transcript_text, folder_name="transcripts"):
11
- if not os.path.exists(folder_name):
12
- os.makedirs(folder_name)
13
  timestamp = datetime.now().strftime("%Y%m%d%H%M%S")
14
  filename = f"{video_id}_{timestamp}.txt"
15
- filepath = os.path.join(folder_name, filename)
16
 
17
  with open(filepath, "w", encoding="utf-8") as f:
18
  f.write('\n'.join(transcript_text))
 
19
  return filepath
20
 
21
 
 
6
 
7
  transcripts = []
8
 
9
+ import os
10
+ from datetime import datetime
11
+
12
+
13
+ def save_transcript(video_id, transcript_text, folder_name="Data/transcripts"):
14
+ #using abosule path
15
+ base_dir = os.path.dirname(os.path.abspath(__file__)) # Directory of the current script
16
+ folder_path = os.path.join(base_dir, folder_name)
17
+
18
+ if not os.path.exists(folder_path):
19
+ os.makedirs(folder_path)
20
 
 
 
 
21
  timestamp = datetime.now().strftime("%Y%m%d%H%M%S")
22
  filename = f"{video_id}_{timestamp}.txt"
23
+ filepath = os.path.join(folder_path, filename)
24
 
25
  with open(filepath, "w", encoding="utf-8") as f:
26
  f.write('\n'.join(transcript_text))
27
+
28
  return filepath
29
 
30
 
Rag/chunking.py CHANGED
@@ -57,5 +57,7 @@ def split_text_to_chunks():
57
  all_splits = split_text_to_chunks()
58
  if all_splits:
59
  print(f"Total chunks created: {len(all_splits)}")
 
 
60
  else:
61
  print("Splitting failed. Check logs for details.")
 
57
  all_splits = split_text_to_chunks()
58
  if all_splits:
59
  print(f"Total chunks created: {len(all_splits)}")
60
+ print(all_splits[0].metadata)
61
+ print(all_splits[1])
62
  else:
63
  print("Splitting failed. Check logs for details.")
Rag/transcripts/SjPJn4QP0dk_20250109191200.txt DELETED
@@ -1,932 +0,0 @@
1
- welcome to hubman lab Essentials where
2
- we revisit past episodes for the most
3
- potent and actionable science-based
4
- tools for mental health physical health
5
- and
6
- performance I'm Andrew huberman and I'm
7
- a professor of neurobiology and
8
- Opthalmology at Stanford School of
9
- Medicine let's continue our discussion
10
- about
11
- neuroplasticity this incredible feature
12
- of our nervous system that allows it to
13
- change itself in response to experience
14
- and even in ways that we consciously and
15
- deliberately decide to change it most
16
- people don't know how to access
17
- neuroplasticity and so that's what this
18
- entire month of the huberman Lab podcast
19
- has been about we've explored
20
- neuroplasticity from a variety of
21
- different perspectives we talked about
22
- representational plasticity we talked
23
- about the importance of focus and reward
24
- we talked about this amazing and
25
- somewhat surprising aspect of the
26
- vestibular system how altering our
27
- relationship to gravity and in addition
28
- to that making error as we try and learn
29
- can open up Windows to plasticity but we
30
- have not really talked so much about
31
- directing the plasticity toward
32
- particular outcomes and thus far we
33
- really haven't talked yet about how to
34
- undo things that we don't want and so
35
- today we are going to explore that
36
- aspect of neuroplasticity and we are
37
- going to do that in the context of a
38
- very important and somewhat sensitive
39
- topic which is pain and in some cases
40
- injury to the nervous system we as
41
- always here on this podcast are going to
42
- discuss some of the science we get into
43
- mechanism but we
44
- also really get at principles principles
45
- are far more important than any one
46
- experiment or one description of
47
- mechanism and certainly far more
48
- important than any one protocol because
49
- principles allow you to think about your
50
- nervous system and work with it in ways
51
- that best serve you so let's start our
52
- discussion about pain and the somata
53
- sensory system the somata sensory system
54
- is as the name implies involved in
55
- understanding touch physical feeling on
56
- our body and the simplest way to think
57
- about the somata sensory system is that
58
- we have little sensors and Those sensors
59
- come in the form of neurons nerve cells
60
- that reside in our skin and in the
61
- deeper layers below the skin we have
62
- some that correspond to and we should
63
- say respond to Mechanical touch so you
64
- know pressure on the top of my hand or a
65
- pinpoint or other sensors for instance
66
- respond to heat to cold some respond to
67
- vibration we have a huge number of
68
- different receptors in our skin and they
69
- take that information and send it down
70
- these wires that we call axons in the
71
- form of electrical signals to our spinal
72
- cord and then up to the brain and within
73
- the spinal cord andin brain we have
74
- centers that interpret that information
75
- that actually make sense of those
76
- electrical signals and this is amazing
77
- because none of those sensors has a
78
- different unique form of information
79
- that it uses it just sends electrical
80
- potentials into the nervous system pain
81
- and The Sensation of pain is Believe It
82
- or Not A controversial word in the
83
- Neuroscience field people prefer to use
84
- the word no acception noors are the
85
- sensors in the skin that detect
86
- particular types of stimuli it actually
87
- comes from the Latin word noera which
88
- means to harm and why would neurosci
89
- does not want to talk about pain well
90
- it's very subjective it has a a mental
91
- component and a physical component we
92
- cannot say that pain is simply an
93
- attempt to avoid physical harm to the
94
- body and here's why they actually can be
95
- dissociated from one another and there's
96
- a famous case that was published in the
97
- British Journal of Medicine where a
98
- construction
99
- worker I think he fell is how the story
100
- went and a 14inch nail went through his
101
- Boot and up through the boot and he was
102
- in excruciating pain just beyond
103
- anything he'd experienced he he reported
104
- that he couldn't even move in any
105
- Dimension even a tiny bit without
106
- feeling excruciating pain they brought
107
- him into the clinic into the hospital
108
- they were able to cut away the boot and
109
- they realized that the nail had gone
110
- between two toes and it had actually not
111
- imp impaled the skin at all his visual
112
- image of the nail going through his boot
113
- gave him the feeling the legitimate
114
- feeling that he was experiencing the
115
- pain of a nail going through his foot
116
- which is incredible because it speaks to
117
- the power of the Mind in this pain
118
- scenario and it also speaks to the power
119
- of the specificity it's not like he
120
- thought that his foot was on fire he
121
- thought because he saw a nail going
122
- through his foot what it was going
123
- through his boot but he thought it was
124
- going through his foot that it was sharp
125
- pain of the sort that a nail would
126
- produce it really speaks to the
127
- incredible capacity that these top down
128
- these you know higher level cognitive
129
- functions have in interpreting what
130
- we're experiencing out in the periphery
131
- even just on the basis of what we see so
132
- why are we talking about pain during a
133
- month on neuroplasticity Well turns out
134
- that the pain system offers a a number
135
- of different principles that we can
136
- leverage to a ensure that if we are ever
137
- injured we are able to understand the
138
- difference between injury and pain
139
- because there is a difference that if
140
- we're ever in pain that we can
141
- understand the difference between injury
142
- and pain that we will be able to
143
- interpret our pain and during the course
144
- of today's podcast I'm going to cover
145
- protocols that help eliminate pain from
146
- both ends of the spectrum from the
147
- periphery at the level of the injury and
148
- through these top- down mental
149
- mechanisms believe it or not we're going
150
- to talk about love a colleague of mine
151
- at Stanford who runs a major pain clinic
152
- um is working on and has published
153
- quality peer- rreview data on the role
154
- of love in modulating the pain response
155
- so what we're talking about today is
156
- plasticity of perception which has
157
- direct bearing on emotional pain and has
158
- direct bearing on trauma so let's get
159
- started in thinking about what happens
160
- with pain and I will tell you just now
161
- that there is a mutation a genetic
162
- mutation in a particular sodium Channel
163
- a sodium channel is uh one of these
164
- little holes in neurons that allows them
165
- to fire Action potentials it's important
166
- to the function of the neuron it's also
167
- important for the development of certain
168
- neurons and there's a particular
169
- mutation there are kids that are born
170
- without this sodium Channel 1.7 if you
171
- want to look it up those kids experience
172
- no pain no pain whatsoever and it is a
173
- terrible situation um they don't tend to
174
- live very long due to accidents it's a
175
- really terrible and unfortunate
176
- circumstance in fact it's
177
- reasonable to speculate that one of the
178
- reasons not all but one of the reasons
179
- why people might differ in their
180
- sensitivity to pain is by way of genetic
181
- variation in how many of these sorts of
182
- receptors that they express people who
183
- make too much of this receptor
184
- experience extreme pain from even subtle
185
- stimul
186
- so let's talk about some of the features
187
- of how we're built physically and how
188
- that relates to pain and how we can
189
- recover from injury so first of all we
190
- have maps of our body surface in our
191
- brain it's called a homunculus that
192
- representation is scaled in a way that
193
- matches sensitivity so the areas of your
194
- body that are most sensitive have a lot
195
- more brain real estate devoted to them
196
- your back is an enormous piece of tissue
197
- compared to your finger finger tip but
198
- your back has fewer receptors devoted to
199
- it and the representation of your back
200
- in your brain is actually pretty small
201
- whereas the representation of your
202
- finger is enormous so the how big a
203
- brain area is devoted to a given body
204
- part is directly related to the density
205
- of receptors in that body part not the
206
- size of the body part you can actually
207
- know how sensitive a given body part is
208
- and how much brain area is devoted to it
209
- through what's called twoo
210
- discrimination you can do this
211
- experiment if you want I think I've
212
- described this once or twice before but
213
- basically if you have someone put um
214
- maybe take two pens and put them maybe 6
215
- Ines apart on your back and and touch
216
- while you're facing away and you they'll
217
- ask you how many points they're touching
218
- you and you say um two but if they move
219
- those closer together say 3 in you're
220
- likely to experience it as one point of
221
- contact whereas on your finger you could
222
- do play that game all day and as long as
223
- there's a millimeter or so spacing you
224
- will know that it's two points as
225
- opposed to one and that's because
226
- there's more pixels more density of
227
- receptors this has direct bearing to
228
- pain because it says that areas of the
229
- body that have denser receptors are
230
- going to be more sensitive to pain than
231
- to others so just as a rule of thumb
232
- areas of your body that are injured that
233
- are large areas that have low
234
- sensitivity before injury likely are
235
- going to experience less pain
236
- and the literature shows will heal more
237
- slowly because they don't have as many
238
- cells around to produce inflammation and
239
- you might say wait I thought
240
- inflammation is bad well one of the
241
- things I really want to get across today
242
- is that inflammation is not bad
243
- inflammation out of control is bad but
244
- inflammation is wonderful inflammation
245
- is the tissue repair response I thought
246
- it might be a nice time to just think
247
- about the relationship between the
248
- periphery and the central maps in a way
249
- that many of you have probably heard
250
- about before which will frame the
251
- discussion a little bit better which is
252
- Phantom limb pain now some of you are
253
- probably familiar with this but for
254
- people that have an arm or a leg or a
255
- finger or some other portion of their
256
- body amputated it's not uncommon for
257
- those people to feel as if they still
258
- have that limb or appendage or piece of
259
- their body Inta and typically
260
- unfortunately the sensation of that limb
261
- is not one of the limb being nice and
262
- relaxed and and you know and just there
263
- the sensation is that the limb is
264
- experiencing pain or is contorted in the
265
- specific orientation that it was around
266
- the time of the injury so if someone has
267
- a you know a blunt force to the hand and
268
- they end up having their hand amputated
269
- typically they will continue to feel
270
- pain in their Phantom hand which is
271
- pretty wild and that's because the
272
- representation of that hand is still
273
- intact in the cortex in the brain
274
- and it's trying to balance its levels of
275
- activity normally it's getting what's
276
- called proprioceptive feedback
277
- proprioception is just our knowledge of
278
- where our limbs are in space it's an
279
- extremely important aspect of our somata
280
- sensory system and there's no appropri
281
- receptive feedback and so a lot of the
282
- circuits start to ramp up their levels
283
- of activity and they become very
284
- conscious of the Phantom limb now um
285
- before my lab was at Stanford I was at
286
- UC San Diego and one of my colleagues
287
- was a guy everyone just calls him by his
288
- lap last name ramachandran who is famous
289
- for understanding this Phantom limb
290
- phenomenon and developing a very simple
291
- but very powerful solution to it that
292
- speaks to the incredible capacity of
293
- top- down modulation and top- down
294
- modulation the ability to use one's
295
- brain cognition and senses to control
296
- pain in the body is something that
297
- everyone not just people missing limbs
298
- or in chronic pain could learn to
299
- benefit from because it is a way to tap
300
- into the our ability to use our mind to
301
- control perceptions of what's happening
302
- in our body so what did ramachandran do
303
- ramachandran had people who were missing
304
- a limb put their intact limb into a box
305
- that had mirrors in it such that when
306
- they looked in the box and they moved
307
- their intact limb the opposite limb
308
- which was a reflection of the intact
309
- limb because they're missing the
310
- opposite limb they would see it as if it
311
- was intact and as they would move their
312
- intact limb they would visualize with
313
- their eyes the the limb that's in the
314
- place of the absent limb so this is all
315
- by mirrors moving around and they would
316
- feel immediate relief from the phantom
317
- pain and he would tell them and they
318
- would direct their hand toward a
319
- orientation that felt comfortable to
320
- them then they would exit the mirror box
321
- they would take their their their hand
322
- out and and they would feel as if the
323
- hand was now in its relaxed normal
324
- position so you could get real time in
325
- moments remapping of the representation
326
- of the hand now that's amazing this is
327
- the kind of thing that all of us would
328
- like to be able to do if we are in pain
329
- because if you do anything for long
330
- enough including live you're going to
331
- experience pain of some sort and this
332
- again I just want to remind you isn't
333
- just about physical injuries and pain
334
- this has direct relevance to emotional
335
- pain as well which we of course we'll
336
- talk talk about so the ramachandran
337
- studies were really profound because
338
- they said a couple of things one
339
- plasticity can be very fast that it can
340
- be driven by the experience of something
341
- just the visual experience and so this
342
- may come as a shock to some of you and
343
- by no means it might trying to be
344
- insensitive but pain is a perceptual
345
- thing as much as it's a physical thing
346
- it's a belief system about what you're
347
- experiencing in your body and that has
348
- important relevance for healing
349
- different types of injury and the pain
350
- associated with that injury now this
351
- brings up another topic which is
352
- definitely related to neuroplasticity
353
- and injury but is a more General one
354
- that I hear about a lot which is
355
- traumatic brain injury many injuries are
356
- not just about the limb and the the lack
357
- of use of the limb but concussion and
358
- head injury but I want to talk a little
359
- bit about what is known about recovery
360
- from concussion and this is very
361
- important because it has implications
362
- for just normal aging as well and offset
363
- setting some of the cognitive decline
364
- and physical decline that occurs with
365
- normal aging typically after TBI there's
366
- a constellation of symptoms that many
367
- people if not all people with TBI report
368
- which is headache photophobia that
369
- lights become kind of aversive sleep
370
- disruption trouble concentrating
371
- sometimes mood issues there's you know a
372
- huge range and of course the severity
373
- will vary
374
- Etc it's very clear that regardless of
375
- whether or not there was a skull break
376
- and regardless of when the TBI happened
377
- and how many times it's happened that
378
- the system that repairs the brain the
379
- adult brain is mainly centered around
380
- this lymphatic system that we call for
381
- the brain the glymphatic system it's
382
- sort of like a sewer system that clears
383
- out the debris that surrounds neurons
384
- especially injured neurons and the
385
- glymphatic system is very active during
386
- sleep and the glymphatic system is
387
- something that you want very active
388
- because it's going to clear away the
389
- debris that sits between the neurons and
390
- the cells that surround the connections
391
- between the neurons called the glea
392
- those cells are actively involved in
393
- repairing the connections between
394
- neurons when damaged so the glymphatic
395
- system is so important that many people
396
- if not all people who get TBI are told
397
- get adequate rest you need to sleep and
398
- that's kind of twofold advice on the one
399
- hand it's telling you to get sleep
400
- because all the good things happen in
401
- sleep it's also about getting those
402
- people to not continue to engage in
403
- their activity fulltime or really try
404
- and Hammer through it the glymphatic
405
- system has been shown to be activated
406
- further in two ways one is that sleeping
407
- on one side not on back or stomach seems
408
- to increase the amount of wash out or
409
- wash through I should say of the
410
- glymphatic system the other thing that
411
- has been shown to improve the function
412
- of the lymphatic system is a certain
413
- form of exercise and I want to be very
414
- very clear here I will never and I am
415
- not suggesting that people exercise in
416
- any way that aggravates their injury or
417
- that goes against their Physician's
418
- advice however there's some interesting
419
- data that zone 2 cardio for 30 to 45
420
- minutes three times a week seems to
421
- improve the rates of clearance of some
422
- of the
423
- debris after injury and in general
424
- injury or no to accelerate and improve
425
- the rates of flow for the lymphatic
426
- system it could be fast walking it could
427
- be jogging if you can do that with your
428
- injury safely could be cycling and this
429
- is really interesting outside of TBI
430
- because what we know from aging is that
431
- aging is a nonlinear process it's not
432
- like with every year of Life your brain
433
- gets a little older it's a has sometimes
434
- it follows what's more like a step
435
- function you get these big jumps in in a
436
- in markers of Aging I guess that we
437
- could think of them as jumps down
438
- because it's a negative thing for most
439
- everybody would like to live longer and
440
- be healthier in brain and body and so
441
- the types of exercise I'm referring to
442
- now are really more about brain
443
- longevity and about keeping the brain
444
- healthy than they are about physical
445
- fitness so I think this is really
446
- interesting and if some of you would
447
- like to know the mechanism or at least
448
- the hypothesize mechanism ISM there's a
449
- a a molecule called aquaporin 4 that is
450
- related to the gal system so Gia are the
451
- it means glue and Latin are these are
452
- these cells in the brain the most
453
- numerous cells in the brain in fact that
454
- in sheath synapses but they're very
455
- Dynamic cells aquaporin 4 is mainly
456
- expressed by the gal cell called the
457
- astroy Astro looks like a little star
458
- incredibly interesting cells and the the
459
- thing to remember is that the asites
460
- bridge the connection between the
461
- neurons
462
- the synapse the connections between them
463
- and the vasculature the blood system and
464
- the gimatic system so this glymphatic
465
- system and the gal asroy system is a
466
- system that we want chronically active
467
- throughout the day as much as possible
468
- so low-level walking Zone 2 cardio and
469
- then at night during slow wave sleep is
470
- then really when this lymphatic system
471
- kicks in so that should hopefully be an
472
- actionable takeaway provided that you
473
- can do that kind of cardio safely
474
- that I believe everybody should be doing
475
- who cares about brain longevity not just
476
- people who are trying to get over TBI
477
- now I'd like to return a little bit to
478
- some of the subjective aspects of pain
479
- modulation because I think it's so
480
- interesting and so actionable that
481
- everyone should know about this our
482
- interpretation our subjective
483
- interpretation of a sensory event is
484
- immensely powerful for dictating our
485
- experience of the event the molecule
486
- adrenaline when it's liberated into our
487
- body truly blunts our experience of pain
488
- we all know the stories of people you
489
- know walking you know miles on stumped
490
- legs um people doing all sorts of things
491
- that were incredible
492
- Feats that allowed them to move through
493
- what would otherwise be pain and
494
- afterward they do experience extreme
495
- pain but during the event often times
496
- they are not experiencing pain and
497
- that's because of the pain blunting
498
- effects of adrenaline adrenaline binding
499
- to particular receptors actually shuts
500
- down pain
501
- Pathways people who anticipate an
502
- injection of morphine immediately report
503
- the feeling of loss of pain their pain
504
- starts to diminish because they know
505
- they're going to get pain relief and
506
- it's a powerful effect now all of you
507
- are probably saying placebo effect
508
- Placebo effects are very real Placebo
509
- effects and belief effects as they're
510
- called have a profound effect on our
511
- experience of noxious stimul like pain
512
- and they can also have a profound effect
513
- on positive stimuli and things that
514
- we're looking forward to one study that
515
- I think is particularly interesting here
516
- from my colleague at Stanford Sean
517
- Mackey they did a neuroimaging study
518
- they subjected people to pain in this
519
- case it was a a heat pain people have
520
- very specific thresholds to heat at
521
- which they cannot tolerate any more heat
522
- but they explored the extent to which
523
- looking at an image of somebody in this
524
- case a romantic partner that the person
525
- loved would allow them to adjust their
526
- pain
527
- response and it turns out it does they
528
- could tolerate more pain and they
529
- reported it as not as
530
- painful that response that feeling of
531
- Love internally can blunt the pain
532
- experience to a significant degree these
533
- are not small effects and not
534
- surprisingly how early a relationship is
535
- how new a relationship is directly
536
- correlat with people's ability they
537
- showed to use this love this internal
538
- representation of love to blunt the pain
539
- response so for those of you that have
540
- been with your partners for many years
541
- and you love them very much and you're
542
- obsessed with them terrific you have a
543
- pre-installed well I suppose it's not
544
- pre-installed you had to do the work
545
- because relationships are work but
546
- you've got a installed mechanism for
547
- blunting pain and again these are not
548
- minor effects these are major effects
549
- and it's all going to be through that
550
- top down modulation that we talked about
551
- not unlike the mirrorbox experiments
552
- with Phantom limb that relieve phantom
553
- pain or some other top- down modulation
554
- in the opposite example is the nail
555
- through the boot which is a visual image
556
- that made the person think it was
557
- painful when in fact it was painful even
558
- though there was no tissue damage it was
559
- all perceptual so the pain system is
560
- really subject to these perceptual
561
- influences which is remarkable because
562
- really when we think about the somata
563
- sensory system it has this cognitive
564
- component it's got this peripheral
565
- component but there's another component
566
- which is the way in which our sensation
567
- our somatos sensory system is woven in
568
- with our autonomic nervous system
569
- independent of love we're going to talk
570
- about something quite different which is
571
- putting needles and electricity in
572
- different parts of the body so-called
573
- acupuncture something that for many
574
- people were it it's been viewed as a
575
- kind of alternative medicine but now
576
- there are excellent Laboratories
577
- exploring what's called
578
- electroacupuncture and acupuncture and I
579
- think what you'll be interested in and
580
- surprised to learn is that it does work
581
- but sometimes it can exacerbate pain and
582
- sometimes it can relieve pain and it all
583
- does that through very discrete Pathways
584
- for which we can really say this neuron
585
- connects to that neuron connects to the
586
- adrenals and we can tie this all back to
587
- dopamine because in the end it's the
588
- chemicals and neural circuits that are
589
- giving rise to these perceptions or
590
- these experiences rather of things that
591
- we call pain love ET Etc there are
592
- actually a lot of really good
593
- peer-reviewed studies supporting the use
594
- of acupuncture for in particular GI trct
595
- issues in recent years there's been an
596
- emphasis on trying to understand the
597
- mechanism of things like acupuncture and
598
- acupuncture itself but as a way to try
599
- and understand how these sorts of
600
- practices might actually benefit people
601
- who are experiencing pain or for
602
- changing the nervous system or brain
603
- body relationship in general what I want
604
- to talk about in terms of acup puncture
605
- is the incredible way in which
606
- acupuncture
607
- illuminates the cross talk between the
608
- somata sensory system our ability to
609
- feel stuff externally exteroception
610
- internally
611
- interoception and how that somata
612
- sensory system is wired in with and
613
- communicating with our autonomic nervous
614
- system that regulates our levels of
615
- alertness or
616
- calmness so this takes us all back to
617
- the homunculus we have this
618
- representation of our body surface in
619
- our
620
- brain that representation is what we
621
- call
622
- somatotopic and what somatotopy is is it
623
- just means that areas of your body that
624
- are near one another are represented by
625
- neurons that are nearby each other in
626
- the brain the connections from those
627
- brain neurons are sent into the body and
628
- they are synchronized with meaning they
629
- Crosswire with and and form synapses
630
- with some of the input from the viscera
631
- from our guts from our diaphragm from
632
- our stomach from our spleen from our
633
- heart our internal organs are sending
634
- information up to this map in our brain
635
- of the body surface but it's about
636
- internal information what we call
637
- interoception our ability to look inside
638
- or imagine inside and feel what we're
639
- feeling inside so the way to think about
640
- this accurately is that our
641
- representation of our self is a
642
- represent ation of our internal workings
643
- our viscera our guts everything inside
644
- our skin and the surface of our skin and
645
- the external World those three things
646
- are always being combined in a very
647
- interesting complex but very seamless
648
- way acupuncture involves taking needles
649
- and sometimes electricity Andor heat as
650
- well and stimulating particular
651
- locations on the body and if somebody
652
- has a gastrointestinal issue like their
653
- their guts are moving too quick they
654
- have diarrhea you stimulate this area
655
- and it'll slow their gut motility down
656
- or if their gut motility is too slow
657
- they're constipated you stimulate
658
- someplace else and it accelerates it and
659
- you know hearing about this of it sounds
660
- kind of to a Westerner who's not
661
- thinking about the underlying neural
662
- circuitry it could sound kind of wacky
663
- but when you look at the neural
664
- circuitry the neuro Anatomy it really
665
- starts to make sense intense stimulation
666
- of the abdomen however with these
667
- electroacupuncture has a very strong
668
- effect of an increasing inflammation in
669
- the body body and this is important to
670
- understand because it's not just that
671
- stimulating the the gut does this
672
- because you're activating the gut area
673
- it activates a particular nerve pathway
674
- for the afficionados it's the splenic
675
- spinal sympathetic axis if you really
676
- want to know and it's pro-inflammatory
677
- under most conditions if for instance
678
- the person is dealing with a particular
679
- bacterial infection that can be
680
- beneficial and this goes back to a much
681
- earlier discussion that we had on a
682
- previous podcast that we'll revisit
683
- again and again which is that the stress
684
- response was designed to combat
685
- infection so it turns out that there are
686
- certain patterns of stimulation on the
687
- abdomen that can actually liberate
688
- immune cells from our immune organs like
689
- our spleen and counter infection when
690
- you stimulate these Pathways that
691
- activate in particular the adrenals the
692
- adrenal gland liberates norepinephrine
693
- and epinephrine and the brain does as
694
- well it binds to what are called the
695
- beta noradrenergic receptor okay so this
696
- is really getting kind of down into the
697
- weeds but the beta nuragic receptors
698
- activate the spleen which liberate cells
699
- that combat infection that's the
700
- short-term quick
701
- response the more intense stimulation of
702
- the abdomen and other areas can be
703
- pro-inflammatory because of the ways
704
- that they trigger certain Loops that go
705
- back to the brain and Trigger the sort
706
- of anxiety Pathways that exacerbates
707
- pain so one pathway stimulates
708
- norepinephrine and blunts PL the other
709
- one doesn't what does all this mean how
710
- are we supposed to put all this together
711
- well there's a paper that was published
712
- in nature medicine in 2014 this is an
713
- excellent Journal that describes how
714
- dopamine can activate the Vegas
715
- peripherally and nor norepinephrine can
716
- activate the Vegas peripherally and
717
- reduce inflammation what this means is
718
- that there are real maps of our body
719
- surface that when
720
- stimulated communicate with our
721
- autonomic nervous system the system
722
- system that controls alertness or
723
- calmness and thereby releases either
724
- molecules like norepinephrine and
725
- dopamine which make us more alert and
726
- blunt our response to pain and they
727
- reduce
728
- inflammation but there are yet other
729
- Pathways that when stimulated are
730
- pro-inflammatory one of the things that
731
- bothers me so much these days and I'm
732
- not easily irritated but what really
733
- bothers me is when people are talking
734
- about inflammation like inflammation is
735
- bad inflammation is terrific
736
- inflammation is the reason why cells are
737
- called to the site of injury to clear it
738
- out inflammation is what's going to
739
- allow you to heal from any injury
740
- chronic inflammation is bad but acute
741
- inflammation is absolutely essential
742
- remember those kids that we talked about
743
- earlier that have mutations in these
744
- receptors that for sensing pain they
745
- never get inflammation and that's why
746
- their joints literally disintegrate it's
747
- really horrible because they don't
748
- actually have the inflammation response
749
- because it was never triggered by the
750
- pain response so I think that the data
751
- on acupuncture turning out to be very
752
- interesting before I continue I just
753
- thought I'd answer a question that I get
754
- a lot uh which is what about Wim Hoff
755
- breathing Wim Hoff also called AKA The
756
- Iceman um has his breathing that's
757
- similar to uh Tumo breathing as it was
758
- originally called involves basically
759
- hyperventilating and then doing some
760
- exhales and some breath holds a number
761
- of people have asked me about it in uh
762
- in relation to pain management the
763
- effect of doing that kind of breathing
764
- it's not a mysterious effect it
765
- liberates adrenaline from the adrenals
766
- when you have adrenaline in your system
767
- and when the spleen is very
768
- active that response is used to counter
769
- infection and stress counters infection
770
- by liberating killer cells in the body
771
- you don't want the stress response to
772
- stay on indefinitely however things like
773
- Wim Hoff breathing like ice baz anything
774
- that releases adrenaline will counter
775
- the infection but you want to regulate
776
- the duration of that adrenaline response
777
- today we've talked about a variety of
778
- tools but I want to Center in on a
779
- particular sequence of tools that
780
- hopefully you won't need but presumably
781
- if you're a human being and you're
782
- active you will need at some point it's
783
- about managing injury and recovering and
784
- healing fast or at least as fast as
785
- possible it includes removing the pain
786
- it includes getting Mobility back and
787
- getting back to a normal life whatever
788
- that means for you
789
- I want to emphasize that what I'm about
790
- to talk about next was developed in
791
- close consultation with Kelly starett
792
- who many of you probably have heard of
793
- before Kelly can be found at the ready
794
- State he's a formally trained so degreed
795
- and educated exercise physiologist he's
796
- a world expert in movement and tissue
797
- Rehabilitation so I asked Kelly I made
798
- it really simple I said okay let's say I
799
- were to sprain my ankle or break my arm
800
- or injure my knee or ACL tear or
801
- something like that or shoulder injury
802
- what are the absolute necessary things
803
- to do regardless of situation so the
804
- first one is a very basic one that now
805
- you have a lot of information to act on
806
- which is sleep is essential and so we
807
- both agreed 8 hours of sleep would be
808
- ideal but if not at least 8 hours
809
- inmobile so that's a
810
- non-negotiable in terms of getting the
811
- foundation for allowing for glymphatic
812
- clearance and tissue clearance Etc the
813
- other is if possible unless it's
814
- absolutely excruciating when you just
815
- can't do it a 10-minute walk per day of
816
- course you don't want to exacerbate the
817
- injury at least a 10-minute walk per day
818
- and probably longer this is where it
819
- gets interesting I was taught I learned
820
- that when you injure yourself you're
821
- supposed to ice something you're
822
- supposed to put ice on it but I didn't
823
- realize this but when speaking to
824
- exercise physiologists and some
825
- Physicians they said that the ice is
826
- really more of a placebo it numbs the
827
- the environment of the injury which is
828
- not surprising and will eliminate the
829
- pain for a short while but it has some
830
- negative effects that perhaps offset its
831
- use it actually can create some like
832
- clotting and sludging of the of the
833
- tissue and fluids which is bad because
834
- you want the macras and the other cell
835
- types phagocytosing eating up the debris
836
- and and injury and moving it out of
837
- there so that it can repair so that was
838
- surprising to me which made me ask well
839
- then what about heat well it turns out
840
- heat is actually quite beneficial the
841
- major effects seem to be explained by
842
- heat improving the viscosity of the
843
- tissues and the clearance and the
844
- profusion of of fluid blood lymph and
845
- other fluids out of the injury area so
846
- all of this might sound just like Common
847
- Sense knowledge I always just thought
848
- it's ice it's non-steroid
849
- anti-inflammatory drugs it's things that
850
- block block prostag gland and so things
851
- like aspirin ibuprofen acetam Menin
852
- those things generally work by blocking
853
- things like the the they're called Co
854
- the Cox uh prostag gland in blockers and
855
- things of that sort things in that
856
- pathway those sorts of treatments which
857
- reduce inflammation may not be so great
858
- at the beginning when you want
859
- inflammation they may be important for
860
- limiting pain so people can be
861
- functional at all but the things that I
862
- talked about today really are anchored
863
- in three principles one is that the
864
- inflammation response is a good one it
865
- calls to the to the sight of injury
866
- things that are going to clean up the
867
- injury in bad cells
868
- then there are going to be things that
869
- are going to improve profusion like the
870
- glymphatic system getting deep sleep
871
- feet elevated sleeping on one side
872
- low-level Zone 2 cardio three times a
873
- week many people ask me about platelet
874
- rich plasma so-called PRP they take
875
- blood they enrich for platelets and they
876
- re-inject it back into people here's the
877
- deal it has never been shown whether or
878
- not the injection itself is what's
879
- actually creating the effect the claims
880
- that PRP actually contains stem cells
881
- are very very feeble and when you look
882
- at the literature and you talk to anyone
883
- expert in the stem cell field they will
884
- tell you that it's the number of stem
885
- cells in PRP is infinim small stem cells
886
- are an exciting area of Technology
887
- however there's a clinic down in Florida
888
- that was shut down a couple years ago
889
- for injecting stem cells harvested from
890
- patients into the eye for immaculate
891
- degener ation these were people that
892
- were suffering from um poor vision and
893
- very shortly after injecting uh these
894
- stem cells into the eyes they went
895
- completely blind and I'm not here to
896
- tell you that you should or shouldn't do
897
- something but I do think that anything
898
- involving stem cells one should be very
899
- cautious of the major issue with stem
900
- cells that I think is concerning is that
901
- stem cells are cells that want to become
902
- lots of different things not just the
903
- tissue that you're interested in so if
904
- you damage your knee and you you inject
905
- stem cells into your knee you need to
906
- molecularly restrict those stem cells so
907
- that they don't become tumor cells right
908
- a tumor is a collection of stem cells
909
- one needs to approach this with Extreme
910
- Caution even if it's your own blood or
911
- stem cells that you're re-injecting so
912
- I'm going to close there I've talked
913
- about a lot of tools today I've talked a
914
- lot about somea sensation about
915
- plasticity about pain about
916
- acupuncture some of the Nuance of
917
- acupuncture inflammation stress we even
918
- talked a little bit about high-intensity
919
- breathing so as always we take kind of a
920
- whirlwind tour through a given topic lay
921
- down some tools as we go hopefully the
922
- principles that relate to pain and
923
- injury but also neuroplasticity in
924
- general today in the context of the
925
- somata sensory system will be of use to
926
- all of you I don't wish injury on any of
927
- you but I do hope that you'll take the
928
- information do with it what you will
929
- once again thanks so much for your time
930
- and attention today and as always thank
931
- you for your interest in science
932
- [Music]