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Using abosulute path to save the newly fetched transcript
Browse files- Data/yt_transcript.py +13 -4
- Rag/chunking.py +2 -0
- Rag/transcripts/SjPJn4QP0dk_20250109191200.txt +0 -932
    	
        Data/yt_transcript.py
    CHANGED
    
    | @@ -6,16 +6,25 @@ from datetime import datetime | |
| 6 |  | 
| 7 | 
             
            transcripts = []
         | 
| 8 |  | 
|  | |
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| 9 |  | 
| 10 | 
            -
            def save_transcript(video_id, transcript_text, folder_name="transcripts"):
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            -
                if not os.path.exists(folder_name):
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            -
                    os.makedirs(folder_name)
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                timestamp = datetime.now().strftime("%Y%m%d%H%M%S")
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                filename = f"{video_id}_{timestamp}.txt"
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            -
                filepath = os.path.join( | 
| 16 |  | 
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                with open(filepath, "w", encoding="utf-8") as f:
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                    f.write('\n'.join(transcript_text))
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                return filepath
         | 
| 20 |  | 
| 21 |  | 
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| 6 |  | 
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            transcripts = []
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| 8 |  | 
| 9 | 
            +
            import os
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            +
            from datetime import datetime
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            +
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            +
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            +
            def save_transcript(video_id, transcript_text, folder_name="Data/transcripts"):
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            +
               #using abosule path
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            +
                base_dir = os.path.dirname(os.path.abspath(__file__))  # Directory of the current script
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            +
                folder_path = os.path.join(base_dir, folder_name)
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            +
             | 
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            +
                if not os.path.exists(folder_path):
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            +
                    os.makedirs(folder_path)
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|  | |
|  | |
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                timestamp = datetime.now().strftime("%Y%m%d%H%M%S")
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                filename = f"{video_id}_{timestamp}.txt"
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            +
                filepath = os.path.join(folder_path, filename)
         | 
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| 25 | 
             
                with open(filepath, "w", encoding="utf-8") as f:
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                    f.write('\n'.join(transcript_text))
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            +
             | 
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                return filepath
         | 
| 29 |  | 
| 30 |  | 
    	
        Rag/chunking.py
    CHANGED
    
    | @@ -57,5 +57,7 @@ def split_text_to_chunks(): | |
| 57 | 
             
            all_splits = split_text_to_chunks()
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            if all_splits:
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                print(f"Total chunks created: {len(all_splits)}")
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            else:
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                print("Splitting failed. Check logs for details.")
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|  | |
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            all_splits = split_text_to_chunks()
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            if all_splits:
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                print(f"Total chunks created: {len(all_splits)}")
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| 60 | 
            +
                print(all_splits[0].metadata)
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            +
                print(all_splits[1])
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            else:
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                print("Splitting failed. Check logs for details.")
         | 
    	
        Rag/transcripts/SjPJn4QP0dk_20250109191200.txt
    DELETED
    
    | @@ -1,932 +0,0 @@ | |
| 1 | 
            -
            welcome to hubman lab Essentials where
         | 
| 2 | 
            -
            we revisit past episodes for the most
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| 3 | 
            -
            potent and actionable science-based
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| 4 | 
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            tools for mental health physical health
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| 5 | 
            -
            and
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            -
            performance I'm Andrew huberman and I'm
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| 7 | 
            -
            a professor of neurobiology and
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| 8 | 
            -
            Opthalmology at Stanford School of
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| 9 | 
            -
            Medicine let's continue our discussion
         | 
| 10 | 
            -
            about
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| 11 | 
            -
            neuroplasticity this incredible feature
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| 12 | 
            -
            of our nervous system that allows it to
         | 
| 13 | 
            -
            change itself in response to experience
         | 
| 14 | 
            -
            and even in ways that we consciously and
         | 
| 15 | 
            -
            deliberately decide to change it most
         | 
| 16 | 
            -
            people don't know how to access
         | 
| 17 | 
            -
            neuroplasticity and so that's what this
         | 
| 18 | 
            -
            entire month of the huberman Lab podcast
         | 
| 19 | 
            -
            has been about we've explored
         | 
| 20 | 
            -
            neuroplasticity from a variety of
         | 
| 21 | 
            -
            different perspectives we talked about
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| 22 | 
            -
            representational plasticity we talked
         | 
| 23 | 
            -
            about the importance of focus and reward
         | 
| 24 | 
            -
            we talked about this amazing and
         | 
| 25 | 
            -
            somewhat surprising aspect of the
         | 
| 26 | 
            -
            vestibular system how altering our
         | 
| 27 | 
            -
            relationship to gravity and in addition
         | 
| 28 | 
            -
            to that making error as we try and learn
         | 
| 29 | 
            -
            can open up Windows to plasticity but we
         | 
| 30 | 
            -
            have not really talked so much about
         | 
| 31 | 
            -
            directing the plasticity toward
         | 
| 32 | 
            -
            particular outcomes and thus far we
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| 33 | 
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            really haven't talked yet about how to
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| 34 | 
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            undo things that we don't want and so
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| 35 | 
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            today we are going to explore that
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| 36 | 
            -
            aspect of neuroplasticity and we are
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| 37 | 
            -
            going to do that in the context of a
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| 38 | 
            -
            very important and somewhat sensitive
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| 39 | 
            -
            topic which is pain and in some cases
         | 
| 40 | 
            -
            injury to the nervous system we as
         | 
| 41 | 
            -
            always here on this podcast are going to
         | 
| 42 | 
            -
            discuss some of the science we get into
         | 
| 43 | 
            -
            mechanism but we
         | 
| 44 | 
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            also really get at principles principles
         | 
| 45 | 
            -
            are far more important than any one
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| 46 | 
            -
            experiment or one description of
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| 47 | 
            -
            mechanism and certainly far more
         | 
| 48 | 
            -
            important than any one protocol because
         | 
| 49 | 
            -
            principles allow you to think about your
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| 50 | 
            -
            nervous system and work with it in ways
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| 51 | 
            -
            that best serve you so let's start our
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| 52 | 
            -
            discussion about pain and the somata
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| 53 | 
            -
            sensory system the somata sensory system
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| 54 | 
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            is as the name implies involved in
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| 55 | 
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            understanding touch physical feeling on
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| 56 | 
            -
            our body and the simplest way to think
         | 
| 57 | 
            -
            about the somata sensory system is that
         | 
| 58 | 
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            we have little sensors and Those sensors
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| 59 | 
            -
            come in the form of neurons nerve cells
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| 60 | 
            -
            that reside in our skin and in the
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| 61 | 
            -
            deeper layers below the skin we have
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| 62 | 
            -
            some that correspond to and we should
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| 63 | 
            -
            say respond to Mechanical touch so you
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| 64 | 
            -
            know pressure on the top of my hand or a
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| 65 | 
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            pinpoint or other sensors for instance
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| 66 | 
            -
            respond to heat to cold some respond to
         | 
| 67 | 
            -
            vibration we have a huge number of
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| 68 | 
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            different receptors in our skin and they
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            take that information and send it down
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| 70 | 
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            these wires that we call axons in the
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| 71 | 
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            form of electrical signals to our spinal
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| 72 | 
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            cord and then up to the brain and within
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| 73 | 
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            the spinal cord andin brain we have
         | 
| 74 | 
            -
            centers that interpret that information
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| 75 | 
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            that actually make sense of those
         | 
| 76 | 
            -
            electrical signals and this is amazing
         | 
| 77 | 
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            because none of those sensors has a
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| 78 | 
            -
            different unique form of information
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| 79 | 
            -
            that it uses it just sends electrical
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| 80 | 
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            potentials into the nervous system pain
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| 81 | 
            -
            and The Sensation of pain is Believe It
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| 82 | 
            -
            or Not A controversial word in the
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| 83 | 
            -
            Neuroscience field people prefer to use
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| 84 | 
            -
            the word no acception noors are the
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| 85 | 
            -
            sensors in the skin that detect
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| 86 | 
            -
            particular types of stimuli it actually
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| 87 | 
            -
            comes from the Latin word noera which
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| 88 | 
            -
            means to harm and why would neurosci
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| 89 | 
            -
            does not want to talk about pain well
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| 90 | 
            -
            it's very subjective it has a a mental
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| 91 | 
            -
            component and a physical component we
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| 92 | 
            -
            cannot say that pain is simply an
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| 93 | 
            -
            attempt to avoid physical harm to the
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| 94 | 
            -
            body and here's why they actually can be
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| 95 | 
            -
            dissociated from one another and there's
         | 
| 96 | 
            -
            a famous case that was published in the
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| 97 | 
            -
            British Journal of Medicine where a
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| 98 | 
            -
            construction
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| 99 | 
            -
            worker I think he fell is how the story
         | 
| 100 | 
            -
            went and a 14inch nail went through his
         | 
| 101 | 
            -
            Boot and up through the boot and he was
         | 
| 102 | 
            -
            in excruciating pain just beyond
         | 
| 103 | 
            -
            anything he'd experienced he he reported
         | 
| 104 | 
            -
            that he couldn't even move in any
         | 
| 105 | 
            -
            Dimension even a tiny bit without
         | 
| 106 | 
            -
            feeling excruciating pain they brought
         | 
| 107 | 
            -
            him into the clinic into the hospital
         | 
| 108 | 
            -
            they were able to cut away the boot and
         | 
| 109 | 
            -
            they realized that the nail had gone
         | 
| 110 | 
            -
            between two toes and it had actually not
         | 
| 111 | 
            -
            imp impaled the skin at all his visual
         | 
| 112 | 
            -
            image of the nail going through his boot
         | 
| 113 | 
            -
            gave him the feeling the legitimate
         | 
| 114 | 
            -
            feeling that he was experiencing the
         | 
| 115 | 
            -
            pain of a nail going through his foot
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| 116 | 
            -
            which is incredible because it speaks to
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| 117 | 
            -
            the power of the Mind in this pain
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| 118 | 
            -
            scenario and it also speaks to the power
         | 
| 119 | 
            -
            of the specificity it's not like he
         | 
| 120 | 
            -
            thought that his foot was on fire he
         | 
| 121 | 
            -
            thought because he saw a nail going
         | 
| 122 | 
            -
            through his foot what it was going
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| 123 | 
            -
            through his boot but he thought it was
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| 124 | 
            -
            going through his foot that it was sharp
         | 
| 125 | 
            -
            pain of the sort that a nail would
         | 
| 126 | 
            -
            produce it really speaks to the
         | 
| 127 | 
            -
            incredible capacity that these top down
         | 
| 128 | 
            -
            these you know higher level cognitive
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| 129 | 
            -
            functions have in interpreting what
         | 
| 130 | 
            -
            we're experiencing out in the periphery
         | 
| 131 | 
            -
            even just on the basis of what we see so
         | 
| 132 | 
            -
            why are we talking about pain during a
         | 
| 133 | 
            -
            month on neuroplasticity Well turns out
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| 134 | 
            -
            that the pain system offers a a number
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| 135 | 
            -
            of different principles that we can
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| 136 | 
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            leverage to a ensure that if we are ever
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| 137 | 
            -
            injured we are able to understand the
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| 138 | 
            -
            difference between injury and pain
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| 139 | 
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            because there is a difference that if
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| 140 | 
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            we're ever in pain that we can
         | 
| 141 | 
            -
            understand the difference between injury
         | 
| 142 | 
            -
            and pain that we will be able to
         | 
| 143 | 
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            interpret our pain and during the course
         | 
| 144 | 
            -
            of today's podcast I'm going to cover
         | 
| 145 | 
            -
            protocols that help eliminate pain from
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| 146 | 
            -
            both ends of the spectrum from the
         | 
| 147 | 
            -
            periphery at the level of the injury and
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| 148 | 
            -
            through these top- down mental
         | 
| 149 | 
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            mechanisms believe it or not we're going
         | 
| 150 | 
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            to talk about love a colleague of mine
         | 
| 151 | 
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            at Stanford who runs a major pain clinic
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| 152 | 
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            um is working on and has published
         | 
| 153 | 
            -
            quality peer- rreview data on the role
         | 
| 154 | 
            -
            of love in modulating the pain response
         | 
| 155 | 
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            so what we're talking about today is
         | 
| 156 | 
            -
            plasticity of perception which has
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| 157 | 
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            direct bearing on emotional pain and has
         | 
| 158 | 
            -
            direct bearing on trauma so let's get
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| 159 | 
            -
            started in thinking about what happens
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| 160 | 
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            with pain and I will tell you just now
         | 
| 161 | 
            -
            that there is a mutation a genetic
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| 162 | 
            -
            mutation in a particular sodium Channel
         | 
| 163 | 
            -
            a sodium channel is uh one of these
         | 
| 164 | 
            -
            little holes in neurons that allows them
         | 
| 165 | 
            -
            to fire Action potentials it's important
         | 
| 166 | 
            -
            to the function of the neuron it's also
         | 
| 167 | 
            -
            important for the development of certain
         | 
| 168 | 
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            neurons and there's a particular
         | 
| 169 | 
            -
            mutation there are kids that are born
         | 
| 170 | 
            -
            without this sodium Channel 1.7 if you
         | 
| 171 | 
            -
            want to look it up those kids experience
         | 
| 172 | 
            -
            no pain no pain whatsoever and it is a
         | 
| 173 | 
            -
            terrible situation um they don't tend to
         | 
| 174 | 
            -
            live very long due to accidents it's a
         | 
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            really terrible and unfortunate
         | 
| 176 | 
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            circumstance in fact it's
         | 
| 177 | 
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            reasonable to speculate that one of the
         | 
| 178 | 
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            reasons not all but one of the reasons
         | 
| 179 | 
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            why people might differ in their
         | 
| 180 | 
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            sensitivity to pain is by way of genetic
         | 
| 181 | 
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            variation in how many of these sorts of
         | 
| 182 | 
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            receptors that they express people who
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| 183 | 
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            make too much of this receptor
         | 
| 184 | 
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            experience extreme pain from even subtle
         | 
| 185 | 
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            stimul
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            -
            so let's talk about some of the features
         | 
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            -
            of how we're built physically and how
         | 
| 188 | 
            -
            that relates to pain and how we can
         | 
| 189 | 
            -
            recover from injury so first of all we
         | 
| 190 | 
            -
            have maps of our body surface in our
         | 
| 191 | 
            -
            brain it's called a homunculus that
         | 
| 192 | 
            -
            representation is scaled in a way that
         | 
| 193 | 
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            matches sensitivity so the areas of your
         | 
| 194 | 
            -
            body that are most sensitive have a lot
         | 
| 195 | 
            -
            more brain real estate devoted to them
         | 
| 196 | 
            -
            your back is an enormous piece of tissue
         | 
| 197 | 
            -
            compared to your finger finger tip but
         | 
| 198 | 
            -
            your back has fewer receptors devoted to
         | 
| 199 | 
            -
            it and the representation of your back
         | 
| 200 | 
            -
            in your brain is actually pretty small
         | 
| 201 | 
            -
            whereas the representation of your
         | 
| 202 | 
            -
            finger is enormous so the how big a
         | 
| 203 | 
            -
            brain area is devoted to a given body
         | 
| 204 | 
            -
            part is directly related to the density
         | 
| 205 | 
            -
            of receptors in that body part not the
         | 
| 206 | 
            -
            size of the body part you can actually
         | 
| 207 | 
            -
            know how sensitive a given body part is
         | 
| 208 | 
            -
            and how much brain area is devoted to it
         | 
| 209 | 
            -
            through what's called twoo
         | 
| 210 | 
            -
            discrimination you can do this
         | 
| 211 | 
            -
            experiment if you want I think I've
         | 
| 212 | 
            -
            described this once or twice before but
         | 
| 213 | 
            -
            basically if you have someone put um
         | 
| 214 | 
            -
            maybe take two pens and put them maybe 6
         | 
| 215 | 
            -
            Ines apart on your back and and touch
         | 
| 216 | 
            -
            while you're facing away and you they'll
         | 
| 217 | 
            -
            ask you how many points they're touching
         | 
| 218 | 
            -
            you and you say um two but if they move
         | 
| 219 | 
            -
            those closer together say 3 in you're
         | 
| 220 | 
            -
            likely to experience it as one point of
         | 
| 221 | 
            -
            contact whereas on your finger you could
         | 
| 222 | 
            -
            do play that game all day and as long as
         | 
| 223 | 
            -
            there's a millimeter or so spacing you
         | 
| 224 | 
            -
            will know that it's two points as
         | 
| 225 | 
            -
            opposed to one and that's because
         | 
| 226 | 
            -
            there's more pixels more density of
         | 
| 227 | 
            -
            receptors this has direct bearing to
         | 
| 228 | 
            -
            pain because it says that areas of the
         | 
| 229 | 
            -
            body that have denser receptors are
         | 
| 230 | 
            -
            going to be more sensitive to pain than
         | 
| 231 | 
            -
            to others so just as a rule of thumb
         | 
| 232 | 
            -
            areas of your body that are injured that
         | 
| 233 | 
            -
            are large areas that have low
         | 
| 234 | 
            -
            sensitivity before injury likely are
         | 
| 235 | 
            -
            going to experience less pain
         | 
| 236 | 
            -
            and the literature shows will heal more
         | 
| 237 | 
            -
            slowly because they don't have as many
         | 
| 238 | 
            -
            cells around to produce inflammation and
         | 
| 239 | 
            -
            you might say wait I thought
         | 
| 240 | 
            -
            inflammation is bad well one of the
         | 
| 241 | 
            -
            things I really want to get across today
         | 
| 242 | 
            -
            is that inflammation is not bad
         | 
| 243 | 
            -
            inflammation out of control is bad but
         | 
| 244 | 
            -
            inflammation is wonderful inflammation
         | 
| 245 | 
            -
            is the tissue repair response I thought
         | 
| 246 | 
            -
            it might be a nice time to just think
         | 
| 247 | 
            -
            about the relationship between the
         | 
| 248 | 
            -
            periphery and the central maps in a way
         | 
| 249 | 
            -
            that many of you have probably heard
         | 
| 250 | 
            -
            about before which will frame the
         | 
| 251 | 
            -
            discussion a little bit better which is
         | 
| 252 | 
            -
            Phantom limb pain now some of you are
         | 
| 253 | 
            -
            probably familiar with this but for
         | 
| 254 | 
            -
            people that have an arm or a leg or a
         | 
| 255 | 
            -
            finger or some other portion of their
         | 
| 256 | 
            -
            body amputated it's not uncommon for
         | 
| 257 | 
            -
            those people to feel as if they still
         | 
| 258 | 
            -
            have that limb or appendage or piece of
         | 
| 259 | 
            -
            their body Inta and typically
         | 
| 260 | 
            -
            unfortunately the sensation of that limb
         | 
| 261 | 
            -
            is not one of the limb being nice and
         | 
| 262 | 
            -
            relaxed and and you know and just there
         | 
| 263 | 
            -
            the sensation is that the limb is
         | 
| 264 | 
            -
            experiencing pain or is contorted in the
         | 
| 265 | 
            -
            specific orientation that it was around
         | 
| 266 | 
            -
            the time of the injury so if someone has
         | 
| 267 | 
            -
            a you know a blunt force to the hand and
         | 
| 268 | 
            -
            they end up having their hand amputated
         | 
| 269 | 
            -
            typically they will continue to feel
         | 
| 270 | 
            -
            pain in their Phantom hand which is
         | 
| 271 | 
            -
            pretty wild and that's because the
         | 
| 272 | 
            -
            representation of that hand is still
         | 
| 273 | 
            -
            intact in the cortex in the brain
         | 
| 274 | 
            -
            and it's trying to balance its levels of
         | 
| 275 | 
            -
            activity normally it's getting what's
         | 
| 276 | 
            -
            called proprioceptive feedback
         | 
| 277 | 
            -
            proprioception is just our knowledge of
         | 
| 278 | 
            -
            where our limbs are in space it's an
         | 
| 279 | 
            -
            extremely important aspect of our somata
         | 
| 280 | 
            -
            sensory system and there's no appropri
         | 
| 281 | 
            -
            receptive feedback and so a lot of the
         | 
| 282 | 
            -
            circuits start to ramp up their levels
         | 
| 283 | 
            -
            of activity and they become very
         | 
| 284 | 
            -
            conscious of the Phantom limb now um
         | 
| 285 | 
            -
            before my lab was at Stanford I was at
         | 
| 286 | 
            -
            UC San Diego and one of my colleagues
         | 
| 287 | 
            -
            was a guy everyone just calls him by his
         | 
| 288 | 
            -
            lap last name ramachandran who is famous
         | 
| 289 | 
            -
            for understanding this Phantom limb
         | 
| 290 | 
            -
            phenomenon and developing a very simple
         | 
| 291 | 
            -
            but very powerful solution to it that
         | 
| 292 | 
            -
            speaks to the incredible capacity of
         | 
| 293 | 
            -
            top- down modulation and top- down
         | 
| 294 | 
            -
            modulation the ability to use one's
         | 
| 295 | 
            -
            brain cognition and senses to control
         | 
| 296 | 
            -
            pain in the body is something that
         | 
| 297 | 
            -
            everyone not just people missing limbs
         | 
| 298 | 
            -
            or in chronic pain could learn to
         | 
| 299 | 
            -
            benefit from because it is a way to tap
         | 
| 300 | 
            -
            into the our ability to use our mind to
         | 
| 301 | 
            -
            control perceptions of what's happening
         | 
| 302 | 
            -
            in our body so what did ramachandran do
         | 
| 303 | 
            -
            ramachandran had people who were missing
         | 
| 304 | 
            -
            a limb put their intact limb into a box
         | 
| 305 | 
            -
            that had mirrors in it such that when
         | 
| 306 | 
            -
            they looked in the box and they moved
         | 
| 307 | 
            -
            their intact limb the opposite limb
         | 
| 308 | 
            -
            which was a reflection of the intact
         | 
| 309 | 
            -
            limb because they're missing the
         | 
| 310 | 
            -
            opposite limb they would see it as if it
         | 
| 311 | 
            -
            was intact and as they would move their
         | 
| 312 | 
            -
            intact limb they would visualize with
         | 
| 313 | 
            -
            their eyes the the limb that's in the
         | 
| 314 | 
            -
            place of the absent limb so this is all
         | 
| 315 | 
            -
            by mirrors moving around and they would
         | 
| 316 | 
            -
            feel immediate relief from the phantom
         | 
| 317 | 
            -
            pain and he would tell them and they
         | 
| 318 | 
            -
            would direct their hand toward a
         | 
| 319 | 
            -
            orientation that felt comfortable to
         | 
| 320 | 
            -
            them then they would exit the mirror box
         | 
| 321 | 
            -
            they would take their their their hand
         | 
| 322 | 
            -
            out and and they would feel as if the
         | 
| 323 | 
            -
            hand was now in its relaxed normal
         | 
| 324 | 
            -
            position so you could get real time in
         | 
| 325 | 
            -
            moments remapping of the representation
         | 
| 326 | 
            -
            of the hand now that's amazing this is
         | 
| 327 | 
            -
            the kind of thing that all of us would
         | 
| 328 | 
            -
            like to be able to do if we are in pain
         | 
| 329 | 
            -
            because if you do anything for long
         | 
| 330 | 
            -
            enough including live you're going to
         | 
| 331 | 
            -
            experience pain of some sort and this
         | 
| 332 | 
            -
            again I just want to remind you isn't
         | 
| 333 | 
            -
            just about physical injuries and pain
         | 
| 334 | 
            -
            this has direct relevance to emotional
         | 
| 335 | 
            -
            pain as well which we of course we'll
         | 
| 336 | 
            -
            talk talk about so the ramachandran
         | 
| 337 | 
            -
            studies were really profound because
         | 
| 338 | 
            -
            they said a couple of things one
         | 
| 339 | 
            -
            plasticity can be very fast that it can
         | 
| 340 | 
            -
            be driven by the experience of something
         | 
| 341 | 
            -
            just the visual experience and so this
         | 
| 342 | 
            -
            may come as a shock to some of you and
         | 
| 343 | 
            -
            by no means it might trying to be
         | 
| 344 | 
            -
            insensitive but pain is a perceptual
         | 
| 345 | 
            -
            thing as much as it's a physical thing
         | 
| 346 | 
            -
            it's a belief system about what you're
         | 
| 347 | 
            -
            experiencing in your body and that has
         | 
| 348 | 
            -
            important relevance for healing
         | 
| 349 | 
            -
            different types of injury and the pain
         | 
| 350 | 
            -
            associated with that injury now this
         | 
| 351 | 
            -
            brings up another topic which is
         | 
| 352 | 
            -
            definitely related to neuroplasticity
         | 
| 353 | 
            -
            and injury but is a more General one
         | 
| 354 | 
            -
            that I hear about a lot which is
         | 
| 355 | 
            -
            traumatic brain injury many injuries are
         | 
| 356 | 
            -
            not just about the limb and the the lack
         | 
| 357 | 
            -
            of use of the limb but concussion and
         | 
| 358 | 
            -
            head injury but I want to talk a little
         | 
| 359 | 
            -
            bit about what is known about recovery
         | 
| 360 | 
            -
            from concussion and this is very
         | 
| 361 | 
            -
            important because it has implications
         | 
| 362 | 
            -
            for just normal aging as well and offset
         | 
| 363 | 
            -
            setting some of the cognitive decline
         | 
| 364 | 
            -
            and physical decline that occurs with
         | 
| 365 | 
            -
            normal aging typically after TBI there's
         | 
| 366 | 
            -
            a constellation of symptoms that many
         | 
| 367 | 
            -
            people if not all people with TBI report
         | 
| 368 | 
            -
            which is headache photophobia that
         | 
| 369 | 
            -
            lights become kind of aversive sleep
         | 
| 370 | 
            -
            disruption trouble concentrating
         | 
| 371 | 
            -
            sometimes mood issues there's you know a
         | 
| 372 | 
            -
            huge range and of course the severity
         | 
| 373 | 
            -
            will vary
         | 
| 374 | 
            -
            Etc it's very clear that regardless of
         | 
| 375 | 
            -
            whether or not there was a skull break
         | 
| 376 | 
            -
            and regardless of when the TBI happened
         | 
| 377 | 
            -
            and how many times it's happened that
         | 
| 378 | 
            -
            the system that repairs the brain the
         | 
| 379 | 
            -
            adult brain is mainly centered around
         | 
| 380 | 
            -
            this lymphatic system that we call for
         | 
| 381 | 
            -
            the brain the glymphatic system it's
         | 
| 382 | 
            -
            sort of like a sewer system that clears
         | 
| 383 | 
            -
            out the debris that surrounds neurons
         | 
| 384 | 
            -
            especially injured neurons and the
         | 
| 385 | 
            -
            glymphatic system is very active during
         | 
| 386 | 
            -
            sleep and the glymphatic system is
         | 
| 387 | 
            -
            something that you want very active
         | 
| 388 | 
            -
            because it's going to clear away the
         | 
| 389 | 
            -
            debris that sits between the neurons and
         | 
| 390 | 
            -
            the cells that surround the connections
         | 
| 391 | 
            -
            between the neurons called the glea
         | 
| 392 | 
            -
            those cells are actively involved in
         | 
| 393 | 
            -
            repairing the connections between
         | 
| 394 | 
            -
            neurons when damaged so the glymphatic
         | 
| 395 | 
            -
            system is so important that many people
         | 
| 396 | 
            -
            if not all people who get TBI are told
         | 
| 397 | 
            -
            get adequate rest you need to sleep and
         | 
| 398 | 
            -
            that's kind of twofold advice on the one
         | 
| 399 | 
            -
            hand it's telling you to get sleep
         | 
| 400 | 
            -
            because all the good things happen in
         | 
| 401 | 
            -
            sleep it's also about getting those
         | 
| 402 | 
            -
            people to not continue to engage in
         | 
| 403 | 
            -
            their activity fulltime or really try
         | 
| 404 | 
            -
            and Hammer through it the glymphatic
         | 
| 405 | 
            -
            system has been shown to be activated
         | 
| 406 | 
            -
            further in two ways one is that sleeping
         | 
| 407 | 
            -
            on one side not on back or stomach seems
         | 
| 408 | 
            -
            to increase the amount of wash out or
         | 
| 409 | 
            -
            wash through I should say of the
         | 
| 410 | 
            -
            glymphatic system the other thing that
         | 
| 411 | 
            -
            has been shown to improve the function
         | 
| 412 | 
            -
            of the lymphatic system is a certain
         | 
| 413 | 
            -
            form of exercise and I want to be very
         | 
| 414 | 
            -
            very clear here I will never and I am
         | 
| 415 | 
            -
            not suggesting that people exercise in
         | 
| 416 | 
            -
            any way that aggravates their injury or
         | 
| 417 | 
            -
            that goes against their Physician's
         | 
| 418 | 
            -
            advice however there's some interesting
         | 
| 419 | 
            -
            data that zone 2 cardio for 30 to 45
         | 
| 420 | 
            -
            minutes three times a week seems to
         | 
| 421 | 
            -
            improve the rates of clearance of some
         | 
| 422 | 
            -
            of the
         | 
| 423 | 
            -
            debris after injury and in general
         | 
| 424 | 
            -
            injury or no to accelerate and improve
         | 
| 425 | 
            -
            the rates of flow for the lymphatic
         | 
| 426 | 
            -
            system it could be fast walking it could
         | 
| 427 | 
            -
            be jogging if you can do that with your
         | 
| 428 | 
            -
            injury safely could be cycling and this
         | 
| 429 | 
            -
            is really interesting outside of TBI
         | 
| 430 | 
            -
            because what we know from aging is that
         | 
| 431 | 
            -
            aging is a nonlinear process it's not
         | 
| 432 | 
            -
            like with every year of Life your brain
         | 
| 433 | 
            -
            gets a little older it's a has sometimes
         | 
| 434 | 
            -
            it follows what's more like a step
         | 
| 435 | 
            -
            function you get these big jumps in in a
         | 
| 436 | 
            -
            in markers of Aging I guess that we
         | 
| 437 | 
            -
            could think of them as jumps down
         | 
| 438 | 
            -
            because it's a negative thing for most
         | 
| 439 | 
            -
            everybody would like to live longer and
         | 
| 440 | 
            -
            be healthier in brain and body and so
         | 
| 441 | 
            -
            the types of exercise I'm referring to
         | 
| 442 | 
            -
            now are really more about brain
         | 
| 443 | 
            -
            longevity and about keeping the brain
         | 
| 444 | 
            -
            healthy than they are about physical
         | 
| 445 | 
            -
            fitness so I think this is really
         | 
| 446 | 
            -
            interesting and if some of you would
         | 
| 447 | 
            -
            like to know the mechanism or at least
         | 
| 448 | 
            -
            the hypothesize mechanism ISM there's a
         | 
| 449 | 
            -
            a a molecule called aquaporin 4 that is
         | 
| 450 | 
            -
            related to the gal system so Gia are the
         | 
| 451 | 
            -
            it means glue and Latin are these are
         | 
| 452 | 
            -
            these cells in the brain the most
         | 
| 453 | 
            -
            numerous cells in the brain in fact that
         | 
| 454 | 
            -
            in sheath synapses but they're very
         | 
| 455 | 
            -
            Dynamic cells aquaporin 4 is mainly
         | 
| 456 | 
            -
            expressed by the gal cell called the
         | 
| 457 | 
            -
            astroy Astro looks like a little star
         | 
| 458 | 
            -
            incredibly interesting cells and the the
         | 
| 459 | 
            -
            thing to remember is that the asites
         | 
| 460 | 
            -
            bridge the connection between the
         | 
| 461 | 
            -
            neurons
         | 
| 462 | 
            -
            the synapse the connections between them
         | 
| 463 | 
            -
            and the vasculature the blood system and
         | 
| 464 | 
            -
            the gimatic system so this glymphatic
         | 
| 465 | 
            -
            system and the gal asroy system is a
         | 
| 466 | 
            -
            system that we want chronically active
         | 
| 467 | 
            -
            throughout the day as much as possible
         | 
| 468 | 
            -
            so low-level walking Zone 2 cardio and
         | 
| 469 | 
            -
            then at night during slow wave sleep is
         | 
| 470 | 
            -
            then really when this lymphatic system
         | 
| 471 | 
            -
            kicks in so that should hopefully be an
         | 
| 472 | 
            -
            actionable takeaway provided that you
         | 
| 473 | 
            -
            can do that kind of cardio safely
         | 
| 474 | 
            -
            that I believe everybody should be doing
         | 
| 475 | 
            -
            who cares about brain longevity not just
         | 
| 476 | 
            -
            people who are trying to get over TBI
         | 
| 477 | 
            -
            now I'd like to return a little bit to
         | 
| 478 | 
            -
            some of the subjective aspects of pain
         | 
| 479 | 
            -
            modulation because I think it's so
         | 
| 480 | 
            -
            interesting and so actionable that
         | 
| 481 | 
            -
            everyone should know about this our
         | 
| 482 | 
            -
            interpretation our subjective
         | 
| 483 | 
            -
            interpretation of a sensory event is
         | 
| 484 | 
            -
            immensely powerful for dictating our
         | 
| 485 | 
            -
            experience of the event the molecule
         | 
| 486 | 
            -
            adrenaline when it's liberated into our
         | 
| 487 | 
            -
            body truly blunts our experience of pain
         | 
| 488 | 
            -
            we all know the stories of people you
         | 
| 489 | 
            -
            know walking you know miles on stumped
         | 
| 490 | 
            -
            legs um people doing all sorts of things
         | 
| 491 | 
            -
            that were incredible
         | 
| 492 | 
            -
            Feats that allowed them to move through
         | 
| 493 | 
            -
            what would otherwise be pain and
         | 
| 494 | 
            -
            afterward they do experience extreme
         | 
| 495 | 
            -
            pain but during the event often times
         | 
| 496 | 
            -
            they are not experiencing pain and
         | 
| 497 | 
            -
            that's because of the pain blunting
         | 
| 498 | 
            -
            effects of adrenaline adrenaline binding
         | 
| 499 | 
            -
            to particular receptors actually shuts
         | 
| 500 | 
            -
            down pain
         | 
| 501 | 
            -
            Pathways people who anticipate an
         | 
| 502 | 
            -
            injection of morphine immediately report
         | 
| 503 | 
            -
            the feeling of loss of pain their pain
         | 
| 504 | 
            -
            starts to diminish because they know
         | 
| 505 | 
            -
            they're going to get pain relief and
         | 
| 506 | 
            -
            it's a powerful effect now all of you
         | 
| 507 | 
            -
            are probably saying placebo effect
         | 
| 508 | 
            -
            Placebo effects are very real Placebo
         | 
| 509 | 
            -
            effects and belief effects as they're
         | 
| 510 | 
            -
            called have a profound effect on our
         | 
| 511 | 
            -
            experience of noxious stimul like pain
         | 
| 512 | 
            -
            and they can also have a profound effect
         | 
| 513 | 
            -
            on positive stimuli and things that
         | 
| 514 | 
            -
            we're looking forward to one study that
         | 
| 515 | 
            -
            I think is particularly interesting here
         | 
| 516 | 
            -
            from my colleague at Stanford Sean
         | 
| 517 | 
            -
            Mackey they did a neuroimaging study
         | 
| 518 | 
            -
            they subjected people to pain in this
         | 
| 519 | 
            -
            case it was a a heat pain people have
         | 
| 520 | 
            -
            very specific thresholds to heat at
         | 
| 521 | 
            -
            which they cannot tolerate any more heat
         | 
| 522 | 
            -
            but they explored the extent to which
         | 
| 523 | 
            -
            looking at an image of somebody in this
         | 
| 524 | 
            -
            case a romantic partner that the person
         | 
| 525 | 
            -
            loved would allow them to adjust their
         | 
| 526 | 
            -
            pain
         | 
| 527 | 
            -
            response and it turns out it does they
         | 
| 528 | 
            -
            could tolerate more pain and they
         | 
| 529 | 
            -
            reported it as not as
         | 
| 530 | 
            -
            painful that response that feeling of
         | 
| 531 | 
            -
            Love internally can blunt the pain
         | 
| 532 | 
            -
            experience to a significant degree these
         | 
| 533 | 
            -
            are not small effects and not
         | 
| 534 | 
            -
            surprisingly how early a relationship is
         | 
| 535 | 
            -
            how new a relationship is directly
         | 
| 536 | 
            -
            correlat with people's ability they
         | 
| 537 | 
            -
            showed to use this love this internal
         | 
| 538 | 
            -
            representation of love to blunt the pain
         | 
| 539 | 
            -
            response so for those of you that have
         | 
| 540 | 
            -
            been with your partners for many years
         | 
| 541 | 
            -
            and you love them very much and you're
         | 
| 542 | 
            -
            obsessed with them terrific you have a
         | 
| 543 | 
            -
            pre-installed well I suppose it's not
         | 
| 544 | 
            -
            pre-installed you had to do the work
         | 
| 545 | 
            -
            because relationships are work but
         | 
| 546 | 
            -
            you've got a installed mechanism for
         | 
| 547 | 
            -
            blunting pain and again these are not
         | 
| 548 | 
            -
            minor effects these are major effects
         | 
| 549 | 
            -
            and it's all going to be through that
         | 
| 550 | 
            -
            top down modulation that we talked about
         | 
| 551 | 
            -
            not unlike the mirrorbox experiments
         | 
| 552 | 
            -
            with Phantom limb that relieve phantom
         | 
| 553 | 
            -
            pain or some other top- down modulation
         | 
| 554 | 
            -
            in the opposite example is the nail
         | 
| 555 | 
            -
            through the boot which is a visual image
         | 
| 556 | 
            -
            that made the person think it was
         | 
| 557 | 
            -
            painful when in fact it was painful even
         | 
| 558 | 
            -
            though there was no tissue damage it was
         | 
| 559 | 
            -
            all perceptual so the pain system is
         | 
| 560 | 
            -
            really subject to these perceptual
         | 
| 561 | 
            -
            influences which is remarkable because
         | 
| 562 | 
            -
            really when we think about the somata
         | 
| 563 | 
            -
            sensory system it has this cognitive
         | 
| 564 | 
            -
            component it's got this peripheral
         | 
| 565 | 
            -
            component but there's another component
         | 
| 566 | 
            -
            which is the way in which our sensation
         | 
| 567 | 
            -
            our somatos sensory system is woven in
         | 
| 568 | 
            -
            with our autonomic nervous system
         | 
| 569 | 
            -
            independent of love we're going to talk
         | 
| 570 | 
            -
            about something quite different which is
         | 
| 571 | 
            -
            putting needles and electricity in
         | 
| 572 | 
            -
            different parts of the body so-called
         | 
| 573 | 
            -
            acupuncture something that for many
         | 
| 574 | 
            -
            people were it it's been viewed as a
         | 
| 575 | 
            -
            kind of alternative medicine but now
         | 
| 576 | 
            -
            there are excellent Laboratories
         | 
| 577 | 
            -
            exploring what's called
         | 
| 578 | 
            -
            electroacupuncture and acupuncture and I
         | 
| 579 | 
            -
            think what you'll be interested in and
         | 
| 580 | 
            -
            surprised to learn is that it does work
         | 
| 581 | 
            -
            but sometimes it can exacerbate pain and
         | 
| 582 | 
            -
            sometimes it can relieve pain and it all
         | 
| 583 | 
            -
            does that through very discrete Pathways
         | 
| 584 | 
            -
            for which we can really say this neuron
         | 
| 585 | 
            -
            connects to that neuron connects to the
         | 
| 586 | 
            -
            adrenals and we can tie this all back to
         | 
| 587 | 
            -
            dopamine because in the end it's the
         | 
| 588 | 
            -
            chemicals and neural circuits that are
         | 
| 589 | 
            -
            giving rise to these perceptions or
         | 
| 590 | 
            -
            these experiences rather of things that
         | 
| 591 | 
            -
            we call pain love ET Etc there are
         | 
| 592 | 
            -
            actually a lot of really good
         | 
| 593 | 
            -
            peer-reviewed studies supporting the use
         | 
| 594 | 
            -
            of acupuncture for in particular GI trct
         | 
| 595 | 
            -
            issues in recent years there's been an
         | 
| 596 | 
            -
            emphasis on trying to understand the
         | 
| 597 | 
            -
            mechanism of things like acupuncture and
         | 
| 598 | 
            -
            acupuncture itself but as a way to try
         | 
| 599 | 
            -
            and understand how these sorts of
         | 
| 600 | 
            -
            practices might actually benefit people
         | 
| 601 | 
            -
            who are experiencing pain or for
         | 
| 602 | 
            -
            changing the nervous system or brain
         | 
| 603 | 
            -
            body relationship in general what I want
         | 
| 604 | 
            -
            to talk about in terms of acup puncture
         | 
| 605 | 
            -
            is the incredible way in which
         | 
| 606 | 
            -
            acupuncture
         | 
| 607 | 
            -
            illuminates the cross talk between the
         | 
| 608 | 
            -
            somata sensory system our ability to
         | 
| 609 | 
            -
            feel stuff externally exteroception
         | 
| 610 | 
            -
            internally
         | 
| 611 | 
            -
            interoception and how that somata
         | 
| 612 | 
            -
            sensory system is wired in with and
         | 
| 613 | 
            -
            communicating with our autonomic nervous
         | 
| 614 | 
            -
            system that regulates our levels of
         | 
| 615 | 
            -
            alertness or
         | 
| 616 | 
            -
            calmness so this takes us all back to
         | 
| 617 | 
            -
            the homunculus we have this
         | 
| 618 | 
            -
            representation of our body surface in
         | 
| 619 | 
            -
            our
         | 
| 620 | 
            -
            brain that representation is what we
         | 
| 621 | 
            -
            call
         | 
| 622 | 
            -
            somatotopic and what somatotopy is is it
         | 
| 623 | 
            -
            just means that areas of your body that
         | 
| 624 | 
            -
            are near one another are represented by
         | 
| 625 | 
            -
            neurons that are nearby each other in
         | 
| 626 | 
            -
            the brain the connections from those
         | 
| 627 | 
            -
            brain neurons are sent into the body and
         | 
| 628 | 
            -
            they are synchronized with meaning they
         | 
| 629 | 
            -
            Crosswire with and and form synapses
         | 
| 630 | 
            -
            with some of the input from the viscera
         | 
| 631 | 
            -
            from our guts from our diaphragm from
         | 
| 632 | 
            -
            our stomach from our spleen from our
         | 
| 633 | 
            -
            heart our internal organs are sending
         | 
| 634 | 
            -
            information up to this map in our brain
         | 
| 635 | 
            -
            of the body surface but it's about
         | 
| 636 | 
            -
            internal information what we call
         | 
| 637 | 
            -
            interoception our ability to look inside
         | 
| 638 | 
            -
            or imagine inside and feel what we're
         | 
| 639 | 
            -
            feeling inside so the way to think about
         | 
| 640 | 
            -
            this accurately is that our
         | 
| 641 | 
            -
            representation of our self is a
         | 
| 642 | 
            -
            represent ation of our internal workings
         | 
| 643 | 
            -
            our viscera our guts everything inside
         | 
| 644 | 
            -
            our skin and the surface of our skin and
         | 
| 645 | 
            -
            the external World those three things
         | 
| 646 | 
            -
            are always being combined in a very
         | 
| 647 | 
            -
            interesting complex but very seamless
         | 
| 648 | 
            -
            way acupuncture involves taking needles
         | 
| 649 | 
            -
            and sometimes electricity Andor heat as
         | 
| 650 | 
            -
            well and stimulating particular
         | 
| 651 | 
            -
            locations on the body and if somebody
         | 
| 652 | 
            -
            has a gastrointestinal issue like their
         | 
| 653 | 
            -
            their guts are moving too quick they
         | 
| 654 | 
            -
            have diarrhea you stimulate this area
         | 
| 655 | 
            -
            and it'll slow their gut motility down
         | 
| 656 | 
            -
            or if their gut motility is too slow
         | 
| 657 | 
            -
            they're constipated you stimulate
         | 
| 658 | 
            -
            someplace else and it accelerates it and
         | 
| 659 | 
            -
            you know hearing about this of it sounds
         | 
| 660 | 
            -
            kind of to a Westerner who's not
         | 
| 661 | 
            -
            thinking about the underlying neural
         | 
| 662 | 
            -
            circuitry it could sound kind of wacky
         | 
| 663 | 
            -
            but when you look at the neural
         | 
| 664 | 
            -
            circuitry the neuro Anatomy it really
         | 
| 665 | 
            -
            starts to make sense intense stimulation
         | 
| 666 | 
            -
            of the abdomen however with these
         | 
| 667 | 
            -
            electroacupuncture has a very strong
         | 
| 668 | 
            -
            effect of an increasing inflammation in
         | 
| 669 | 
            -
            the body body and this is important to
         | 
| 670 | 
            -
            understand because it's not just that
         | 
| 671 | 
            -
            stimulating the the gut does this
         | 
| 672 | 
            -
            because you're activating the gut area
         | 
| 673 | 
            -
            it activates a particular nerve pathway
         | 
| 674 | 
            -
            for the afficionados it's the splenic
         | 
| 675 | 
            -
            spinal sympathetic axis if you really
         | 
| 676 | 
            -
            want to know and it's pro-inflammatory
         | 
| 677 | 
            -
            under most conditions if for instance
         | 
| 678 | 
            -
            the person is dealing with a particular
         | 
| 679 | 
            -
            bacterial infection that can be
         | 
| 680 | 
            -
            beneficial and this goes back to a much
         | 
| 681 | 
            -
            earlier discussion that we had on a
         | 
| 682 | 
            -
            previous podcast that we'll revisit
         | 
| 683 | 
            -
            again and again which is that the stress
         | 
| 684 | 
            -
            response was designed to combat
         | 
| 685 | 
            -
            infection so it turns out that there are
         | 
| 686 | 
            -
            certain patterns of stimulation on the
         | 
| 687 | 
            -
            abdomen that can actually liberate
         | 
| 688 | 
            -
            immune cells from our immune organs like
         | 
| 689 | 
            -
            our spleen and counter infection when
         | 
| 690 | 
            -
            you stimulate these Pathways that
         | 
| 691 | 
            -
            activate in particular the adrenals the
         | 
| 692 | 
            -
            adrenal gland liberates norepinephrine
         | 
| 693 | 
            -
            and epinephrine and the brain does as
         | 
| 694 | 
            -
            well it binds to what are called the
         | 
| 695 | 
            -
            beta noradrenergic receptor okay so this
         | 
| 696 | 
            -
            is really getting kind of down into the
         | 
| 697 | 
            -
            weeds but the beta nuragic receptors
         | 
| 698 | 
            -
            activate the spleen which liberate cells
         | 
| 699 | 
            -
            that combat infection that's the
         | 
| 700 | 
            -
            short-term quick
         | 
| 701 | 
            -
            response the more intense stimulation of
         | 
| 702 | 
            -
            the abdomen and other areas can be
         | 
| 703 | 
            -
            pro-inflammatory because of the ways
         | 
| 704 | 
            -
            that they trigger certain Loops that go
         | 
| 705 | 
            -
            back to the brain and Trigger the sort
         | 
| 706 | 
            -
            of anxiety Pathways that exacerbates
         | 
| 707 | 
            -
            pain so one pathway stimulates
         | 
| 708 | 
            -
            norepinephrine and blunts PL the other
         | 
| 709 | 
            -
            one doesn't what does all this mean how
         | 
| 710 | 
            -
            are we supposed to put all this together
         | 
| 711 | 
            -
            well there's a paper that was published
         | 
| 712 | 
            -
            in nature medicine in 2014 this is an
         | 
| 713 | 
            -
            excellent Journal that describes how
         | 
| 714 | 
            -
            dopamine can activate the Vegas
         | 
| 715 | 
            -
            peripherally and nor norepinephrine can
         | 
| 716 | 
            -
            activate the Vegas peripherally and
         | 
| 717 | 
            -
            reduce inflammation what this means is
         | 
| 718 | 
            -
            that there are real maps of our body
         | 
| 719 | 
            -
            surface that when
         | 
| 720 | 
            -
            stimulated communicate with our
         | 
| 721 | 
            -
            autonomic nervous system the system
         | 
| 722 | 
            -
            system that controls alertness or
         | 
| 723 | 
            -
            calmness and thereby releases either
         | 
| 724 | 
            -
            molecules like norepinephrine and
         | 
| 725 | 
            -
            dopamine which make us more alert and
         | 
| 726 | 
            -
            blunt our response to pain and they
         | 
| 727 | 
            -
            reduce
         | 
| 728 | 
            -
            inflammation but there are yet other
         | 
| 729 | 
            -
            Pathways that when stimulated are
         | 
| 730 | 
            -
            pro-inflammatory one of the things that
         | 
| 731 | 
            -
            bothers me so much these days and I'm
         | 
| 732 | 
            -
            not easily irritated but what really
         | 
| 733 | 
            -
            bothers me is when people are talking
         | 
| 734 | 
            -
            about inflammation like inflammation is
         | 
| 735 | 
            -
            bad inflammation is terrific
         | 
| 736 | 
            -
            inflammation is the reason why cells are
         | 
| 737 | 
            -
            called to the site of injury to clear it
         | 
| 738 | 
            -
            out inflammation is what's going to
         | 
| 739 | 
            -
            allow you to heal from any injury
         | 
| 740 | 
            -
            chronic inflammation is bad but acute
         | 
| 741 | 
            -
            inflammation is absolutely essential
         | 
| 742 | 
            -
            remember those kids that we talked about
         | 
| 743 | 
            -
            earlier that have mutations in these
         | 
| 744 | 
            -
            receptors that for sensing pain they
         | 
| 745 | 
            -
            never get inflammation and that's why
         | 
| 746 | 
            -
            their joints literally disintegrate it's
         | 
| 747 | 
            -
            really horrible because they don't
         | 
| 748 | 
            -
            actually have the inflammation response
         | 
| 749 | 
            -
            because it was never triggered by the
         | 
| 750 | 
            -
            pain response so I think that the data
         | 
| 751 | 
            -
            on acupuncture turning out to be very
         | 
| 752 | 
            -
            interesting before I continue I just
         | 
| 753 | 
            -
            thought I'd answer a question that I get
         | 
| 754 | 
            -
            a lot uh which is what about Wim Hoff
         | 
| 755 | 
            -
            breathing Wim Hoff also called AKA The
         | 
| 756 | 
            -
            Iceman um has his breathing that's
         | 
| 757 | 
            -
            similar to uh Tumo breathing as it was
         | 
| 758 | 
            -
            originally called involves basically
         | 
| 759 | 
            -
            hyperventilating and then doing some
         | 
| 760 | 
            -
            exhales and some breath holds a number
         | 
| 761 | 
            -
            of people have asked me about it in uh
         | 
| 762 | 
            -
            in relation to pain management the
         | 
| 763 | 
            -
            effect of doing that kind of breathing
         | 
| 764 | 
            -
            it's not a mysterious effect it
         | 
| 765 | 
            -
            liberates adrenaline from the adrenals
         | 
| 766 | 
            -
            when you have adrenaline in your system
         | 
| 767 | 
            -
            and when the spleen is very
         | 
| 768 | 
            -
            active that response is used to counter
         | 
| 769 | 
            -
            infection and stress counters infection
         | 
| 770 | 
            -
            by liberating killer cells in the body
         | 
| 771 | 
            -
            you don't want the stress response to
         | 
| 772 | 
            -
            stay on indefinitely however things like
         | 
| 773 | 
            -
            Wim Hoff breathing like ice baz anything
         | 
| 774 | 
            -
            that releases adrenaline will counter
         | 
| 775 | 
            -
            the infection but you want to regulate
         | 
| 776 | 
            -
            the duration of that adrenaline response
         | 
| 777 | 
            -
            today we've talked about a variety of
         | 
| 778 | 
            -
            tools but I want to Center in on a
         | 
| 779 | 
            -
            particular sequence of tools that
         | 
| 780 | 
            -
            hopefully you won't need but presumably
         | 
| 781 | 
            -
            if you're a human being and you're
         | 
| 782 | 
            -
            active you will need at some point it's
         | 
| 783 | 
            -
            about managing injury and recovering and
         | 
| 784 | 
            -
            healing fast or at least as fast as
         | 
| 785 | 
            -
            possible it includes removing the pain
         | 
| 786 | 
            -
            it includes getting Mobility back and
         | 
| 787 | 
            -
            getting back to a normal life whatever
         | 
| 788 | 
            -
            that means for you
         | 
| 789 | 
            -
            I want to emphasize that what I'm about
         | 
| 790 | 
            -
            to talk about next was developed in
         | 
| 791 | 
            -
            close consultation with Kelly starett
         | 
| 792 | 
            -
            who many of you probably have heard of
         | 
| 793 | 
            -
            before Kelly can be found at the ready
         | 
| 794 | 
            -
            State he's a formally trained so degreed
         | 
| 795 | 
            -
            and educated exercise physiologist he's
         | 
| 796 | 
            -
            a world expert in movement and tissue
         | 
| 797 | 
            -
            Rehabilitation so I asked Kelly I made
         | 
| 798 | 
            -
            it really simple I said okay let's say I
         | 
| 799 | 
            -
            were to sprain my ankle or break my arm
         | 
| 800 | 
            -
            or injure my knee or ACL tear or
         | 
| 801 | 
            -
            something like that or shoulder injury
         | 
| 802 | 
            -
            what are the absolute necessary things
         | 
| 803 | 
            -
            to do regardless of situation so the
         | 
| 804 | 
            -
            first one is a very basic one that now
         | 
| 805 | 
            -
            you have a lot of information to act on
         | 
| 806 | 
            -
            which is sleep is essential and so we
         | 
| 807 | 
            -
            both agreed 8 hours of sleep would be
         | 
| 808 | 
            -
            ideal but if not at least 8 hours
         | 
| 809 | 
            -
            inmobile so that's a
         | 
| 810 | 
            -
            non-negotiable in terms of getting the
         | 
| 811 | 
            -
            foundation for allowing for glymphatic
         | 
| 812 | 
            -
            clearance and tissue clearance Etc the
         | 
| 813 | 
            -
            other is if possible unless it's
         | 
| 814 | 
            -
            absolutely excruciating when you just
         | 
| 815 | 
            -
            can't do it a 10-minute walk per day of
         | 
| 816 | 
            -
            course you don't want to exacerbate the
         | 
| 817 | 
            -
            injury at least a 10-minute walk per day
         | 
| 818 | 
            -
            and probably longer this is where it
         | 
| 819 | 
            -
            gets interesting I was taught I learned
         | 
| 820 | 
            -
            that when you injure yourself you're
         | 
| 821 | 
            -
            supposed to ice something you're
         | 
| 822 | 
            -
            supposed to put ice on it but I didn't
         | 
| 823 | 
            -
            realize this but when speaking to
         | 
| 824 | 
            -
            exercise physiologists and some
         | 
| 825 | 
            -
            Physicians they said that the ice is
         | 
| 826 | 
            -
            really more of a placebo it numbs the
         | 
| 827 | 
            -
            the environment of the injury which is
         | 
| 828 | 
            -
            not surprising and will eliminate the
         | 
| 829 | 
            -
            pain for a short while but it has some
         | 
| 830 | 
            -
            negative effects that perhaps offset its
         | 
| 831 | 
            -
            use it actually can create some like
         | 
| 832 | 
            -
            clotting and sludging of the of the
         | 
| 833 | 
            -
            tissue and fluids which is bad because
         | 
| 834 | 
            -
            you want the macras and the other cell
         | 
| 835 | 
            -
            types phagocytosing eating up the debris
         | 
| 836 | 
            -
            and and injury and moving it out of
         | 
| 837 | 
            -
            there so that it can repair so that was
         | 
| 838 | 
            -
            surprising to me which made me ask well
         | 
| 839 | 
            -
            then what about heat well it turns out
         | 
| 840 | 
            -
            heat is actually quite beneficial the
         | 
| 841 | 
            -
            major effects seem to be explained by
         | 
| 842 | 
            -
            heat improving the viscosity of the
         | 
| 843 | 
            -
            tissues and the clearance and the
         | 
| 844 | 
            -
            profusion of of fluid blood lymph and
         | 
| 845 | 
            -
            other fluids out of the injury area so
         | 
| 846 | 
            -
            all of this might sound just like Common
         | 
| 847 | 
            -
            Sense knowledge I always just thought
         | 
| 848 | 
            -
            it's ice it's non-steroid
         | 
| 849 | 
            -
            anti-inflammatory drugs it's things that
         | 
| 850 | 
            -
            block block prostag gland and so things
         | 
| 851 | 
            -
            like aspirin ibuprofen acetam Menin
         | 
| 852 | 
            -
            those things generally work by blocking
         | 
| 853 | 
            -
            things like the the they're called Co
         | 
| 854 | 
            -
            the Cox uh prostag gland in blockers and
         | 
| 855 | 
            -
            things of that sort things in that
         | 
| 856 | 
            -
            pathway those sorts of treatments which
         | 
| 857 | 
            -
            reduce inflammation may not be so great
         | 
| 858 | 
            -
            at the beginning when you want
         | 
| 859 | 
            -
            inflammation they may be important for
         | 
| 860 | 
            -
            limiting pain so people can be
         | 
| 861 | 
            -
            functional at all but the things that I
         | 
| 862 | 
            -
            talked about today really are anchored
         | 
| 863 | 
            -
            in three principles one is that the
         | 
| 864 | 
            -
            inflammation response is a good one it
         | 
| 865 | 
            -
            calls to the to the sight of injury
         | 
| 866 | 
            -
            things that are going to clean up the
         | 
| 867 | 
            -
            injury in bad cells
         | 
| 868 | 
            -
            then there are going to be things that
         | 
| 869 | 
            -
            are going to improve profusion like the
         | 
| 870 | 
            -
            glymphatic system getting deep sleep
         | 
| 871 | 
            -
            feet elevated sleeping on one side
         | 
| 872 | 
            -
            low-level Zone 2 cardio three times a
         | 
| 873 | 
            -
            week many people ask me about platelet
         | 
| 874 | 
            -
            rich plasma so-called PRP they take
         | 
| 875 | 
            -
            blood they enrich for platelets and they
         | 
| 876 | 
            -
            re-inject it back into people here's the
         | 
| 877 | 
            -
            deal it has never been shown whether or
         | 
| 878 | 
            -
            not the injection itself is what's
         | 
| 879 | 
            -
            actually creating the effect the claims
         | 
| 880 | 
            -
            that PRP actually contains stem cells
         | 
| 881 | 
            -
            are very very feeble and when you look
         | 
| 882 | 
            -
            at the literature and you talk to anyone
         | 
| 883 | 
            -
            expert in the stem cell field they will
         | 
| 884 | 
            -
            tell you that it's the number of stem
         | 
| 885 | 
            -
            cells in PRP is infinim small stem cells
         | 
| 886 | 
            -
            are an exciting area of Technology
         | 
| 887 | 
            -
            however there's a clinic down in Florida
         | 
| 888 | 
            -
            that was shut down a couple years ago
         | 
| 889 | 
            -
            for injecting stem cells harvested from
         | 
| 890 | 
            -
            patients into the eye for immaculate
         | 
| 891 | 
            -
            degener ation these were people that
         | 
| 892 | 
            -
            were suffering from um poor vision and
         | 
| 893 | 
            -
            very shortly after injecting uh these
         | 
| 894 | 
            -
            stem cells into the eyes they went
         | 
| 895 | 
            -
            completely blind and I'm not here to
         | 
| 896 | 
            -
            tell you that you should or shouldn't do
         | 
| 897 | 
            -
            something but I do think that anything
         | 
| 898 | 
            -
            involving stem cells one should be very
         | 
| 899 | 
            -
            cautious of the major issue with stem
         | 
| 900 | 
            -
            cells that I think is concerning is that
         | 
| 901 | 
            -
            stem cells are cells that want to become
         | 
| 902 | 
            -
            lots of different things not just the
         | 
| 903 | 
            -
            tissue that you're interested in so if
         | 
| 904 | 
            -
            you damage your knee and you you inject
         | 
| 905 | 
            -
            stem cells into your knee you need to
         | 
| 906 | 
            -
            molecularly restrict those stem cells so
         | 
| 907 | 
            -
            that they don't become tumor cells right
         | 
| 908 | 
            -
            a tumor is a collection of stem cells
         | 
| 909 | 
            -
            one needs to approach this with Extreme
         | 
| 910 | 
            -
            Caution even if it's your own blood or
         | 
| 911 | 
            -
            stem cells that you're re-injecting so
         | 
| 912 | 
            -
            I'm going to close there I've talked
         | 
| 913 | 
            -
            about a lot of tools today I've talked a
         | 
| 914 | 
            -
            lot about somea sensation about
         | 
| 915 | 
            -
            plasticity about pain about
         | 
| 916 | 
            -
            acupuncture some of the Nuance of
         | 
| 917 | 
            -
            acupuncture inflammation stress we even
         | 
| 918 | 
            -
            talked a little bit about high-intensity
         | 
| 919 | 
            -
            breathing so as always we take kind of a
         | 
| 920 | 
            -
            whirlwind tour through a given topic lay
         | 
| 921 | 
            -
            down some tools as we go hopefully the
         | 
| 922 | 
            -
            principles that relate to pain and
         | 
| 923 | 
            -
            injury but also neuroplasticity in
         | 
| 924 | 
            -
            general today in the context of the
         | 
| 925 | 
            -
            somata sensory system will be of use to
         | 
| 926 | 
            -
            all of you I don't wish injury on any of
         | 
| 927 | 
            -
            you but I do hope that you'll take the
         | 
| 928 | 
            -
            information do with it what you will
         | 
| 929 | 
            -
            once again thanks so much for your time
         | 
| 930 | 
            -
            and attention today and as always thank
         | 
| 931 | 
            -
            you for your interest in science
         | 
| 932 | 
            -
            [Music]
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