metadata

license: cc-by-nc-nd-4.0
language:
  - en
tags:
  - spatial-proteomics
  - multiplex imaging
  - pathology
  - vision
  - pytorch
  - self-supervised
extra_gated_prompt: >-
  This model and associated code are released under the CC-BY-NC-ND 4.0 license
  and may only be used for non-commercial, academic research purposes with
  proper attribution. Any commercial use, sale, or other monetization of the
  KRONOS model and its derivatives, which include models trained on outputs from
  the KRONOS model or datasets created from the KRONOS model, is prohibited and
  requires prior approval. Please note that the primary email used to sign up
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  (affiliation, research use) is correct and up-to-date. Downloading the model
  requires prior registration on Hugging Face and agreeing to the terms of use.
  By downloading this model, you agree not to distribute, publish or reproduce a
  copy of the model. If another user within your organization wishes to use the
  KRONOS model, they must register as an individual user and agree to comply
  with the terms of use. Users may not attempt to re-identify the deidentified
  data used to develop the underlying model. If you are a commercial entity,
  please contact the corresponding author.
extra_gated_fields:
  Full name (first and last): text
  Current affiliation (no abbreviations): text
  Type of Affiliation:
    type: select
    options:
      - Academia
      - Industry
      - label: Other
        value: other
  Current and official institutional email (**this must match your primary email in your Hugging Face account, @gmail/@hotmail/@qq email domains will be denied**): text
  Please explain your intended research use in detail: text
  I agree to all terms outlined above: checkbox
  I agree to use this model for non-commercial, academic research purposes only: checkbox
  I agree not to distribute the model, if another user within your organization wishes to use the KRONOS model, they must register as an individual user: checkbox
metrics:
  - accuracy
pipeline_tag: image-feature-extraction
library_name: timm

Model Card for KRONOS

What is KRONOS?

KRONOS is a panel-agnostic foundation model for spatial proteomics, self-supervised on 47 million single-marker patches spanning 175 protein markers, 16 tissue types, 8 imaging platforms and 5 institutions. Its architecture couples a shared channel-wise stem with sinusoidal marker-identity embeddings, making it natively compatible with high-dimensional multiplex data.

Copyright & Licence

The KRONOS codebase and pretrained weights are released to the academic community for non-commercial academic research only. Any commercial research use, integration into commercial products or services, or creation of derivative models (including those further trained, fine-tuned, or distilled from KRONOS) requires prior approvals.

Requesting Access

As mentioned in the gated prompt, you must agree to the outlined terms of use, with the primary email for your HuggingFace account matching your institutional email. If your primary email is a personal email (@gmail/@hotmail/@qq) your request will be denied. To fix this, you can: (1) add your official institutional email to your HF account, and confirm your email address to verify, and (2) set your institutional email as your primary email in your HF account. Other reasons for your request access being denied include other mistakes in the form submitted, for example: full name includes abbreviations, affiliation is not spelled out, the described research use is not sufficient, or email domain address not recognized.

Model Description

Developed by: Mahmood Lab AI for Pathology @ Harvard/BWH
Model type: Multiplex Vision Transformer-Small
Pretraining dataset: 47 million patches from multiplex spatial proteomic images
Repository: https://github.com/mahmoodlab/KRONOS
Paper: TBD
License: CC-BY-NC-ND-4.0

License and Terms of Use

This model and associated code are released under the CC-BY-NC-ND 4.0 license and may only be used for non-commercial, academic research purposes with proper attribution. Any commercial use, sale, or other monetization of the KRONOS model and its derivatives, which include models trained on outputs from the KRONOS model or datasets created from the KRONOS model, is prohibited and requires prior approval. Downloading the model requires prior registration on Hugging Face and agreeing to the terms of use. By downloading this model, you agree not to distribute, publish or reproduce a copy of the model. If another user within your organization wishes to use the KRONOS model, they must register as an individual user and agree to comply with the terms of use. Users may not attempt to re-identify the deidentified data used to develop the underlying model. If you are a commercial entity, please contact the corresponding author.

Contact

For any additional questions or comments, contact Faisal Mahmood (faisalmahmood@bwh.harvard.edu), or Muhammad Shaban (mshaban@bwh.harvard.edu).