adding short model card
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by
clem
HF Staff
- opened
README.md
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license: mit
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---
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license: mit
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tags:
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- biology
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- chemistry
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- protein-structure
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- binding-affinity
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- drug-discovery
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- biomolecular-modeling
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- boltz
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- boltz-2
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- deep-learning
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- structural-biology
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---
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# Boltz-2: Accurate and Efficient Biomolecular Interaction Prediction
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**Boltz-2** is an open-source deep learning model for biomolecular interaction prediction, developed by researchers at MIT and Recursion. It extends the capabilities of its predecessor, Boltz-1, by jointly modeling complex 3D structures and binding affinities, achieving near-physics-based accuracy while operating approximately 1000 times faster than traditional methods. This advancement makes accurate *in silico* screening practical for early-stage drug discovery.
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## 🧬 Model Overview
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Boltz-2 is designed to predict:
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- **3D structures** of biomolecular complexes, including proteins, RNA, DNA, and small molecules.
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- **Binding affinities**, providing insights into molecular interactions critical for drug design.
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Key features:
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- **Joint Modeling**: Simultaneously predicts structural conformations and binding affinities.
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- **Speed and Efficiency**: Achieves near-free energy perturbation (FEP) accuracy with significantly reduced computational requirements.
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- **Open-Source**: Released under the MIT license, encouraging both academic and commercial use.
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