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however , there are conflicting reports concerning the existence of a `` '' therapeutic window '' '' for the usual antidepressives such as amitriptyline , nortriptyline , chlorimipramine , imipramine , desipramine and maprotiline .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "l antidepressiv",
"pos": [
113,
128
]
}
|
{
"id": "C0011685",
"name": ", desiprami",
"pos": [
200,
211
]
}
|
the beneficial antiarrhythmic and antifibrillatory actions of flecainide affect only the arrhythmias resulting from transmural necrosis of the myocardium ( `` '' in-hospital arrhythmias '' '' , 2nd-phase arrhythmias '' '' ) , whereas the incidence of early ventricular arrhythmias , especially ventricular fibrillation occurring in the very inception of myocardial ischaemia ( `` '' pre-hospital arrhythmias '' '' , `` '' 1st-phase arrhythmias '' '' ) is not prevented .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
15,
29
]
}
|
{
"id": "C0016229",
"name": "flecainide",
"pos": [
62,
72
]
}
|
in comparison with the previous study , the antidepressant action of zimelidine showed no statistically significant difference from clomipramine .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
44,
58
]
}
|
{
"id": "C0009010",
"name": "clomipramine",
"pos": [
132,
144
]
}
|
in a randomized double-blind group comparison study of 40 patients with endogenous depression zimelidine appeared to be as effective an antidepressant as amitriptyline at 4 and 6 weeks using the hamilton rating scale ( hrs ) and the montgomery and asberg depression rating scale ( madrs ) .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
136,
150
]
}
|
{
"id": "C0002600",
"name": "amitriptyline",
"pos": [
154,
167
]
}
|
the results indicate that a subdivision of antidepressants into four groups can be made according to inhibitory effect on salivation : ( a ) isocarboxazide and lithium citrate with no effect , ( b ) zimelidine and nomifensine with slight effect , ( c ) imipramine oxide and mianserin with moderate effect and ( d ) maprotiline , nortriptyline , clomipramine , imipramine , and amitriptyline with pronounced effect .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
43,
58
]
}
|
{
"id": "C0028420",
"name": "nortriptyline",
"pos": [
329,
342
]
}
|
the results indicate that a subdivision of antidepressants into four groups can be made according to inhibitory effect on salivation : ( a ) isocarboxazide and lithium citrate with no effect , ( b ) zimelidine and nomifensine with slight effect , ( c ) imipramine oxide and mianserin with moderate effect and ( d ) maprotiline , nortriptyline , clomipramine , imipramine , and amitriptyline with pronounced effect .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
43,
58
]
}
|
{
"id": "C0009010",
"name": "clomipramine",
"pos": [
345,
357
]
}
|
the results indicate that a subdivision of antidepressants into four groups can be made according to inhibitory effect on salivation : ( a ) isocarboxazide and lithium citrate with no effect , ( b ) zimelidine and nomifensine with slight effect , ( c ) imipramine oxide and mianserin with moderate effect and ( d ) maprotiline , nortriptyline , clomipramine , imipramine , and amitriptyline with pronounced effect .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
43,
58
]
}
|
{
"id": "C0020934",
"name": "imipramine",
"pos": [
360,
370
]
}
|
the results indicate that a subdivision of antidepressants into four groups can be made according to inhibitory effect on salivation : ( a ) isocarboxazide and lithium citrate with no effect , ( b ) zimelidine and nomifensine with slight effect , ( c ) imipramine oxide and mianserin with moderate effect and ( d ) maprotiline , nortriptyline , clomipramine , imipramine , and amitriptyline with pronounced effect .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
43,
58
]
}
|
{
"id": "C0002600",
"name": "amitriptyline",
"pos": [
377,
390
]
}
|
there is synergistic antibacterial activity between ct and dact regardless of relative minimum inhibitory concentrations of the agents .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
}
|
{
"id": "C0007554",
"name": "ct",
"pos": [
61,
63
]
}
|
the antibacterial action of streptomycin , neomycin , and kanamycin was essentially eliminated by the high salt concentration needed to maintain the protoplasts .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0038425",
"name": "streptomycin",
"pos": [
28,
40
]
}
|
the antibacterial action of streptomycin , neomycin , and kanamycin was essentially eliminated by the high salt concentration needed to maintain the protoplasts .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0027603",
"name": "neomycin",
"pos": [
43,
51
]
}
|
the antibacterial action of streptomycin , neomycin , and kanamycin was essentially eliminated by the high salt concentration needed to maintain the protoplasts .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0022487",
"name": "kanamycin",
"pos": [
58,
67
]
}
|
studies on its toxicity and action in avian and simian malaria show that its chronic toxicity in monkeys is similar to that of the established antimalarials and that it lacks causal prophylactic , gametocidal and sporontocidal activity against plasmodium gallinaceum.dds is also inferior to the established antimalarials in its schizontocidal activity against p. gallinaceum , while against p. knowlesi its activity is of the same order as that of proguanil and against p. cynomolgi it is more effective than quinine , mepacrine , pyrimethamine , chloroquine and proguanil but less effective than sulfadiazine .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "antimalarials",
"pos": [
143,
156
]
}
|
{
"id": "C0008269",
"name": "chloroquine",
"pos": [
547,
558
]
}
|
studies on its toxicity and action in avian and simian malaria show that its chronic toxicity in monkeys is similar to that of the established antimalarials and that it lacks causal prophylactic , gametocidal and sporontocidal activity against plasmodium gallinaceum.dds is also inferior to the established antimalarials in its schizontocidal activity against p. gallinaceum , while against p. knowlesi its activity is of the same order as that of proguanil and against p. cynomolgi it is more effective than quinine , mepacrine , pyrimethamine , chloroquine and proguanil but less effective than sulfadiazine .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "antimalarials",
"pos": [
143,
156
]
}
|
{
"id": "C0008241",
"name": "proguanil",
"pos": [
563,
572
]
}
|
[ comparative antiarrhythmic and antitoxic activity of beta-hexamethyleneimino-para-butoxypropiophenone , novocaine amide and quinidine in arrhythmia , induced by calcium chlorides in mice ] .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
14,
28
]
}
|
{
"id": "C0034414",
"name": "quinidine",
"pos": [
126,
135
]
}
|
[ effect of a neuroleptic , haloperidol , on the gestation and prenatal development of rodents . results of 3 groups of experiments ] .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptic",
"pos": [
14,
25
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
28,
39
]
}
|
in vitro assays showed that low concentrations ( 5 -- 10 and 20 microgram/ml ) of the antimicrobial paromomycin sulfate are able to block or diminish significantly the transfer of the tetracycline resistance r-factor between escherichia coli and salmonella pullorum .
|
therapeutic_class_of
|
{
"id": "C1136254",
"name": "antimicrobial",
"pos": [
86,
99
]
}
|
{
"id": "C0039644",
"name": "tetracycline",
"pos": [
184,
196
]
}
|
the clinically effective antidepressant imipramine , an iminodibenzyl structure , was examined in two experimental methods which had previously demonstrated high prediction ability in descerning and categorizing potential psychotherapeutic drugs .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
25,
39
]
}
|
{
"id": "C0020934",
"name": "imipramine",
"pos": [
40,
50
]
}
|
[ anti-arrhythmia action of mexiletine ( ko 1173 ) on ventricular ectopic arrhythmias in dependence of its serum concentration ] .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "anti-arrhythmia",
"pos": [
2,
17
]
}
|
{
"id": "C0025887",
"name": "mexiletine",
"pos": [
28,
38
]
}
|
[ comparative study of the effects on the antiarrhythmic drugs procainamide , quinidine , diphenylhidantoin and spirohidantoin compounds derived from the nor-tropane system on the potentials of membrane and transport of sodium through the frog skin ( author 's transl ) ] .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
42,
62
]
}
|
{
"id": "C0033216",
"name": "procainamide",
"pos": [
63,
75
]
}
|
[ comparative study of the effects on the antiarrhythmic drugs procainamide , quinidine , diphenylhidantoin and spirohidantoin compounds derived from the nor-tropane system on the potentials of membrane and transport of sodium through the frog skin ( author 's transl ) ] .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
42,
62
]
}
|
{
"id": "C0034414",
"name": "quinidine",
"pos": [
78,
87
]
}
|
from the results obtained calculated on the survivance percentage , was concluded that the best antifungal is the 5 fluorocytosine + amphotericin b association .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
96,
106
]
}
|
{
"id": "C0016278",
"name": "5 fluorocytosine",
"pos": [
114,
130
]
}
|
from the results obtained calculated on the survivance percentage , was concluded that the best antifungal is the 5 fluorocytosine + amphotericin b association .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
96,
106
]
}
|
{
"id": "C0002679",
"name": "amphotericin b",
"pos": [
133,
147
]
}
|
all these agents had less intrinsic antibacterial activity than trimethoprim , and there was marked cross-resistance between trimethoprim on the one hand and pyrimethamine and methasquin on the other .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
36,
49
]
}
|
{
"id": "C0041041",
"name": "trimethoprim",
"pos": [
125,
137
]
}
|
this latter effect can be reversed by subchronic treatment with the antidepressant drugs amitriptyline and mianserine ( org gb 94 ) .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant drugs",
"pos": [
68,
88
]
}
|
{
"id": "C0002600",
"name": "amitriptyline",
"pos": [
89,
102
]
}
|
in a anaesthetized dogs , the antiarrhythmic drug disopyramide was injected directly into the sinus nodal artery in doses that ranged from 10 to 200 microgram/ml .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
30,
49
]
}
|
{
"id": "C0012702",
"name": "disopyramide",
"pos": [
50,
62
]
}
|
the development of antifungal agents is described from the first antibiotics to amphotericin b and 5-fluorocytosine .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agents",
"pos": [
19,
36
]
}
|
{
"id": "C0002679",
"name": "amphotericin b",
"pos": [
80,
94
]
}
|
the development of antifungal agents is described from the first antibiotics to amphotericin b and 5-fluorocytosine .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agents",
"pos": [
19,
36
]
}
|
{
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
99,
115
]
}
|
the antimalarials quinine , chloroquine , primaquine , and quinacrine inhibited the uptake and incorporation of amino acids in vivo , but these drugs had considerably less effect on cell-free protein synthesis .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "antimalarials",
"pos": [
4,
17
]
}
|
{
"id": "C0008269",
"name": "chloroquine",
"pos": [
28,
39
]
}
|
the antimalarials quinine , chloroquine , primaquine , and quinacrine inhibited the uptake and incorporation of amino acids in vivo , but these drugs had considerably less effect on cell-free protein synthesis .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "antimalarials",
"pos": [
4,
17
]
}
|
{
"id": "C0033126",
"name": "primaquine",
"pos": [
42,
52
]
}
|
a comparison of the cardiac activity of a new antiarrhythmic drug -- pipazetate -- with quinidine , procainamide , antazoline and diphenylhydantoin .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
46,
60
]
}
|
{
"id": "C0034414",
"name": "quinidine",
"pos": [
88,
97
]
}
|
a comparison of the cardiac activity of a new antiarrhythmic drug -- pipazetate -- with quinidine , procainamide , antazoline and diphenylhydantoin .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
46,
60
]
}
|
{
"id": "C0033216",
"name": "procainamide",
"pos": [
100,
112
]
}
|
from these results , antiarrhythmic effects of disopyramide under hypoxia appear to depend on ( 1 ) depressed conduction and resultant conversion of unidirectional block to bidirectional block abolishing reentry , and ( 2 ) decreased vulnerability due to decreased inhomogeneity of repolarization .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
21,
35
]
}
|
{
"id": "C0012702",
"name": "disopyramide",
"pos": [
47,
59
]
}
|
in in vivo mouse tests ( inhibition of tetrabenazine-induced ptosis and potentiation of yohimbine toxicity ) which are predictive of antidepressant-like activity , 10a is comparable to amitriptyline .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
133,
147
]
}
|
{
"id": "C0002600",
"name": "amitriptyline",
"pos": [
185,
198
]
}
|
the anticholinergic activity of clinically useful antidepressants , such as amitriptyline , is a proposed cause of side effects which reduce patient compliance .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
50,
65
]
}
|
{
"id": "C0002600",
"name": "amitriptyline",
"pos": [
76,
89
]
}
|
antibacterial activity of ceftizoxime against 7 strains of e. coli , 6 strains of klebsiella , 6 strains of h. influenzae , 7 strains of e. cloacae and 10 strains of s. aureus , recently isolated from patients , was compared with that of cefotiam , cefmetazole and cefazolin .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
}
|
{
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
26,
37
]
}
|
antibacterial activity of ceftizoxime against 7 strains of e. coli , 6 strains of klebsiella , 6 strains of h. influenzae , 7 strains of e. cloacae and 10 strains of s. aureus , recently isolated from patients , was compared with that of cefotiam , cefmetazole and cefazolin .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
}
|
{
"id": "C0007546",
"name": "cefazolin",
"pos": [
265,
274
]
}
|
antibacterial activities of czx and ctm were compared against s. aureus , e. coli , k. pneumoniae , e. cloacae , h. influenzae and e. aerogenes ;
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
}
|
{
"id": "C0007560",
"name": "czx",
"pos": [
28,
31
]
}
|
the antibacterial activities of czx were measured by plate dilution method against clinical isolates of s. aureus , e. coli , k. pneumoniae and p. aeruginosa .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0007560",
"name": "czx",
"pos": [
32,
35
]
}
|
the new antiarrhythmic drug flecainide ( 2,5-bis- ( 2,2,2-trifluoroethoxy ) -n- ( 2-piperidylmethyl ) benzamide acetate ) increases action potential duration at 30 and 90 % repolarization , and functional refractory period in guinea pig papillary muscle up to 10 mumol/l , but shortens the action potential and decreases its amplitude at 30 mumol/l , without significant change in resting potential .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
8,
27
]
}
|
{
"id": "C0016229",
"name": "flecainide",
"pos": [
28,
38
]
}
|
we studied the effect of the antiarrhythmic compound mexiletine on the maximal rate of rise ( v max ) on the action potential and on conduction velocity in isolated papillary muscles of guinea pigs .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
29,
43
]
}
|
{
"id": "C0025887",
"name": "mexiletine",
"pos": [
53,
63
]
}
|
comparative study of the antiarrhythmic efficacy of mexiletine and disopyramide in patients with chronic ventricular arrhythmias .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
25,
39
]
}
|
{
"id": "C0025887",
"name": "mexiletine",
"pos": [
52,
62
]
}
|
comparative study of the antiarrhythmic efficacy of mexiletine and disopyramide in patients with chronic ventricular arrhythmias .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
25,
39
]
}
|
{
"id": "C0012702",
"name": "disopyramide",
"pos": [
67,
79
]
}
|
72 patients severely immunocompromised by their underlying disease ( marrow aplasia , acute leukaemia , or solid tumour ) or by the treatment they were receiving , or both , were randomised to receive antifungal prophylaxis with either oral ketoconazole or conventional doses of oral amphotericin b and nystatin .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
201,
211
]
}
|
{
"id": "C0022625",
"name": "ketoconazole",
"pos": [
241,
253
]
}
|
the permeability of the blood-brain barrier ( bbb ) to methotrexate , na+ , and cl- was studied in rats treated with the membrane-active antifungal agent amphotericin b .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agent",
"pos": [
137,
153
]
}
|
{
"id": "C0002679",
"name": "amphotericin b",
"pos": [
154,
168
]
}
|
at present the basic antimalarial drugs are still the 4-aminoquinolines chloroquine and amodiaquine , the combinations of antifol compounds ( such as pyrimethamine and sulfadoxine = fansidar ) , and quinine .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "antimalarial drugs",
"pos": [
21,
39
]
}
|
{
"id": "C0008269",
"name": "chloroquine",
"pos": [
72,
83
]
}
|
thirty-one patients treated with one of six neuroleptic drugs ( thioridazine , trifluoperazine , haloperidol , chlorpromazine , thiothixene , or fluphenazine ) participated in this study .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
44,
61
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
97,
108
]
}
|
thirty-one patients treated with one of six neuroleptic drugs ( thioridazine , trifluoperazine , haloperidol , chlorpromazine , thiothixene , or fluphenazine ) participated in this study .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
44,
61
]
}
|
{
"id": "C0039955",
"name": "thiothixene",
"pos": [
128,
139
]
}
|
a new anthelmintic drug , albendazole , has been tested in a multicenter double-blind placebo controlled study in 392 patients from france and west africa in children and adults with single or mixed infections caused by roundworms , hookworms , whipworms , threadworms and tapeworms .
|
therapeutic_class_of
|
{
"id": "C0003158",
"name": "anthelmintic drug",
"pos": [
6,
23
]
}
|
{
"id": "C0001911",
"name": "albendazole",
"pos": [
26,
37
]
}
|
the antibacterial activity and pharmacokinetics of the beta-lactamase-stable cephalosporin cefuroxime and the gram-negative beta-lactamase-susceptible cephalosporin cefazolin were compared in two contrasting infection models in which proteus morganii 82 , which produces chromosomally mediated beta-lactamase , was the pathogen .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0007562",
"name": "cefuroxime",
"pos": [
91,
101
]
}
|
the antibacterial activity and pharmacokinetics of the beta-lactamase-stable cephalosporin cefuroxime and the gram-negative beta-lactamase-susceptible cephalosporin cefazolin were compared in two contrasting infection models in which proteus morganii 82 , which produces chromosomally mediated beta-lactamase , was the pathogen .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0007546",
"name": "cefazolin",
"pos": [
165,
174
]
}
|
with the exception of moxalactam , the antibacterial activity in cerebrospinal fluid and change in concentration of bacteria during therapy with the test drugs were comparable to those of penicillin g in pneumococcal infection .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
39,
52
]
}
|
{
"id": "C0030827",
"name": "penicillin g",
"pos": [
188,
200
]
}
|
in vitro studies based on periodic viable count determinations indicated that the two antifungal drugs ketoconazole and 5-fluorocytosine generally were at least additive in their combined effect on various opportunistic yeast pathogens , including some resistant to 5-fluorocytosine .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
86,
102
]
}
|
{
"id": "C0022625",
"name": "ketoconazole",
"pos": [
103,
115
]
}
|
in vitro studies based on periodic viable count determinations indicated that the two antifungal drugs ketoconazole and 5-fluorocytosine generally were at least additive in their combined effect on various opportunistic yeast pathogens , including some resistant to 5-fluorocytosine .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
86,
102
]
}
|
{
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
266,
282
]
}
|
furthermore , the effect of ( - ) cathinone was inhibited by pretreatment of the animals with the neuroleptics haloperidol , spiroperidol , pimozide , flupentixol and butaclamol .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptics",
"pos": [
98,
110
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
111,
122
]
}
|
furthermore , the effect of ( - ) cathinone was inhibited by pretreatment of the animals with the neuroleptics haloperidol , spiroperidol , pimozide , flupentixol and butaclamol .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptics",
"pos": [
98,
110
]
}
|
{
"id": "C0031935",
"name": "pimozide",
"pos": [
140,
148
]
}
|
the previous medication , phenytoin sodium and other antiepileptic drugs , was changed to valproate sodium ( deprakine [ finland ] ; depakene syrup , comparable us product ) , clonazepam ( clonopin ) , and phenobarbital , and the patients ' conditions improved .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
53,
72
]
}
|
{
"id": "C0037567",
"name": "valproate sodium",
"pos": [
90,
106
]
}
|
it had previously been shown that naloxone inhibited the analgesic effect of the antidepressant clomipramine .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
81,
95
]
}
|
{
"id": "C0009010",
"name": "clomipramine",
"pos": [
96,
108
]
}
|
previous studies in mice have shown that quinidine and cupreidine have equivalent antiarrhythmic potencies , whereas the acute toxicity of cupreidine is about 50 % less than that of quinidine .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
82,
96
]
}
|
{
"id": "C0034414",
"name": "quinidine",
"pos": [
182,
191
]
}
|
a normal bone response of pte indicates that antiepileptic treatment with phenobarbital and phenytoin does not affect pth-stimulated bone resorption in the investigated patients .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic",
"pos": [
45,
58
]
}
|
{
"id": "C0031507",
"name": "phenytoin",
"pos": [
92,
101
]
}
|
chronic treatment with anxiolytics ( diazepam , lorazepam , or chlordiazepoxide ) , neuroleptics ( chlorpromazine or haloperidol ) stimulants ( amphetamine or caffeine ) , or depressants ( phenobarbital or ethanol ) was not .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptics",
"pos": [
84,
96
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
117,
128
]
}
|
it is concluded that pimozide in dose ranges from 40-60 mg has powerful antipsychotic properties indistinguishable from those of haloperidol but exerts stronger extrapyramidal side effects .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "antipsychotic",
"pos": [
72,
85
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
129,
140
]
}
|
this study confirms reports that mianserin is an effective antidepressant which is better tolerated and produces fewer side-effects ( especially anticholinergic ) than comparable tricyclic antidepressants such as clomipramine .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
59,
73
]
}
|
{
"id": "C0009010",
"name": "clomipramine",
"pos": [
213,
225
]
}
|
local effects of antibacterial therapy ( benzyl-penicillin ) on missile wound infection rate and tissue devitalization when debridement is delayed for twelve hours .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
17,
30
]
}
|
{
"id": "C0030827",
"name": "benzyl-penicillin",
"pos": [
41,
58
]
}
|
antiarrhythmic efficacy and electrophysiologic actions of amiodarone in patients with life-threatening ventricular arrhythmias : potent suppression of spontaneously occurring tachyarrhythmias versus inconsistent abolition of induced ventricular tachycardia .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
0,
14
]
}
|
{
"id": "C0002598",
"name": "amiodarone",
"pos": [
58,
68
]
}
|
the authors compared the nontricyclic antidepressant trazodone with amitriptyline and placebo in a double-blind study of 202 unipolar depressed outpatients .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
38,
52
]
}
|
{
"id": "C0002600",
"name": "amitriptyline",
"pos": [
68,
81
]
}
|
antibacterial activity and beta-lactamase stability of ceftazidime , an aminothiazolyl cephalosporin potentially active against pseudomonas aeruginosa .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
}
|
{
"id": "C0007559",
"name": "ceftazidime",
"pos": [
55,
66
]
}
|
some representative antifungal agents in current use ( i.e. , amphotericin b , 5-fluorocytosine , and miconazole ) effected significant reductions in the numbers of c. albicans in homogenates of gastrointestinal organs .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agents",
"pos": [
20,
37
]
}
|
{
"id": "C0002679",
"name": "amphotericin b",
"pos": [
62,
76
]
}
|
some representative antifungal agents in current use ( i.e. , amphotericin b , 5-fluorocytosine , and miconazole ) effected significant reductions in the numbers of c. albicans in homogenates of gastrointestinal organs .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agents",
"pos": [
20,
37
]
}
|
{
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
79,
95
]
}
|
some representative antifungal agents in current use ( i.e. , amphotericin b , 5-fluorocytosine , and miconazole ) effected significant reductions in the numbers of c. albicans in homogenates of gastrointestinal organs .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agents",
"pos": [
20,
37
]
}
|
{
"id": "C0025942",
"name": "miconazole",
"pos": [
102,
112
]
}
|
the new antimalarial drug mefloquine bound with high affinity ( kd approximately 3 x 10-7 m ) to membrane lipids of normal mouse erythrocytes and of erythrocytes infected either with chloroquine-susceptible or chloroquine-resistant plasmodium berghei .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
8,
25
]
}
|
{
"id": "C0025153",
"name": "mefloquine",
"pos": [
26,
36
]
}
|
the new antimalarial drug mefloquine bound with high affinity ( kd approximately 3 x 10-7 m ) to membrane lipids of normal mouse erythrocytes and of erythrocytes infected either with chloroquine-susceptible or chloroquine-resistant plasmodium berghei .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "antimalarial drug",
"pos": [
8,
25
]
}
|
{
"id": "C0008269",
"name": "chloroquine",
"pos": [
210,
221
]
}
|
antibacterial activity and lack of antagonism between moxalactam and ampicillin was confirmed in a model of lethal meningococcal infection in mice .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
0,
13
]
}
|
{
"id": "C0002680",
"name": "ampicillin",
"pos": [
69,
79
]
}
|
the binding of [ 14c ] serotonin and mao activity in brain preparations was inhibited by cns antidepressants ( imipramine ) or stimulants ( caffeine ) , by hallucinogens ( n , n-dimethyltryptamine ) , sedatives ( chlorpromazine ) , and other drugs .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
93,
108
]
}
|
{
"id": "C0020934",
"name": "imipramine",
"pos": [
111,
121
]
}
|
with 24 head of wild boars ( sus scrofa l. ) of both sexes of the age of one to two years , kept in a game preserve and naturally infected with parasites of the species mestastrongylus pudendotectus , m. elongatus , ascarops strongylina , physocephalus sexalatus , ascaris suum , globocephalus urosubulatus , oesophagostomum dentatum , trichocephalus suis , eimeria debliecki , and e. perminuta , three experiments were performed with feeds premedicated with anthelmintics : pyrantel tartrate + diethylcarbamazine tartrate ( a dose of 25 + 50 mg kg-1 of live weight ) , mebendazole 5 p. c. premix and mebendazole 50 p. c. premix ( doses of 10 mg kg-1 and 40 mg kg-1 of live weight ) administered for three consecutive days .
|
therapeutic_class_of
|
{
"id": "C0003158",
"name": "anthelmintics",
"pos": [
459,
472
]
}
|
{
"id": "C0025023",
"name": "mebendazole",
"pos": [
601,
612
]
}
|
lately , strains of e. coli , klebsiella , enterobacter , serratia , proteus and pseudomonas resistant to many antimicrobials ( ampicillin , carbenicillin , cephalothin , chloramphenicol , gentamycin , tobramycin , sisomycin , neomycin , paromomycin , kanamycin , streptomycin , spectinomycin , tetracycline , sulphonamides ) were isolated from patients of the university hospital in zuerich .
|
therapeutic_class_of
|
{
"id": "C1136254",
"name": "antimicrobials",
"pos": [
111,
125
]
}
|
{
"id": "C0039644",
"name": "tetracycline",
"pos": [
295,
307
]
}
|
in a preceding paper the genetics of resistance of 2 representative strains exhibiting resistance to beta-lactam antibiotics ( ampicillin , catbenicillin , cephalothin ) to aminoglycosides ( kanamycin , neomycin , paromomycin , gentamycin , sisomycin , tobramycin , streptomycin , spectinomycin ) and further antimicrobials ( tetracycline , chloramphenicol , suphonamides ) were described .
|
therapeutic_class_of
|
{
"id": "C1136254",
"name": "antimicrobials",
"pos": [
309,
323
]
}
|
{
"id": "C0039644",
"name": "tetracycline",
"pos": [
326,
338
]
}
|
to assess the potential of ctm in combined drug regimens , antifungal effects of ctm together with 5-fluorocytosine ( 5-fc ) or amphotericin b ( amb ) were tested in a synthetic liquid medium against candida albicans , candida tropicalis , and torulopsis glabrata .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
59,
69
]
}
|
{
"id": "C0016278",
"name": "5-fc",
"pos": [
118,
122
]
}
|
to assess the potential of ctm in combined drug regimens , antifungal effects of ctm together with 5-fluorocytosine ( 5-fc ) or amphotericin b ( amb ) were tested in a synthetic liquid medium against candida albicans , candida tropicalis , and torulopsis glabrata .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
59,
69
]
}
|
{
"id": "C0002679",
"name": "amphotericin",
"pos": [
128,
140
]
}
|
the in vitro antibacterial spectrum of pirbenicillin includes escherichia coli , serratia , citrobacter , and enterobacter isolates , against which it exhibited minimal inhibitory concentration values comparable to those of carbenicillin .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0006976",
"name": "carbenicillin",
"pos": [
224,
237
]
}
|
the study of the inhibitory activity of ribostamvcin ( vistamycin ) , an antibiotic derived from streptomyces ribosidificus , on 161 strains of gram-negative bacilli shows that the antibacterial spectrum of this antibiotic is identical to that of kanamycin .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
181,
194
]
}
|
{
"id": "C0022487",
"name": "kanamycin",
"pos": [
247,
256
]
}
|
metabolic effects of bunaftine , a new antiarrhythmic agent : comparison with quinidine , ajmaline , procainamide , xylocaine and propranolol .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
39,
59
]
}
|
{
"id": "C0034414",
"name": "quinidine",
"pos": [
78,
87
]
}
|
metabolic effects of bunaftine , a new antiarrhythmic agent : comparison with quinidine , ajmaline , procainamide , xylocaine and propranolol .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
39,
59
]
}
|
{
"id": "C0033216",
"name": "procainamide",
"pos": [
101,
113
]
}
|
effects of four antiepileptic drugs , viz. , diphenylhydantoin , trimethadione , phenobarbitone and ethosuximide , were studied on different in vitro and in vivo skeletal muscle preparations which consisted of frog rectus , rat phrenic nerve diaphragm and cat gastrocnemius sciatic nerve preparations .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic",
"pos": [
16,
29
]
}
|
{
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
45,
62
]
}
|
effects of four antiepileptic drugs , viz. , diphenylhydantoin , trimethadione , phenobarbitone and ethosuximide , were studied on different in vitro and in vivo skeletal muscle preparations which consisted of frog rectus , rat phrenic nerve diaphragm and cat gastrocnemius sciatic nerve preparations .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic",
"pos": [
16,
29
]
}
|
{
"id": "C0041038",
"name": "trimethadione",
"pos": [
65,
78
]
}
|
effects of four antiepileptic drugs , viz. , diphenylhydantoin , trimethadione , phenobarbitone and ethosuximide , were studied on different in vitro and in vivo skeletal muscle preparations which consisted of frog rectus , rat phrenic nerve diaphragm and cat gastrocnemius sciatic nerve preparations .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic",
"pos": [
16,
29
]
}
|
{
"id": "C0015043",
"name": "ethosuximide",
"pos": [
100,
112
]
}
|
a double-blind study of the antiepileptic effect and side effects of carbamazepine ( carb ) and diphenylhydantoin ( dph ) was undertaken in 38 patients with psychomotor epilepsy and without grand mal epilepsy except for a single previous seizure .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic",
"pos": [
28,
41
]
}
|
{
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
96,
113
]
}
|
plasmodium berghei : phase contrast and electron microscopical evidence that certain antimalarials can both inhibit and reverse pigment clumping caused by chloroquine .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "antimalarials",
"pos": [
85,
98
]
}
|
{
"id": "C0008269",
"name": "chloroquine",
"pos": [
155,
166
]
}
|
in addition , ame was less toxic than ab toward kb cells grown in media containing 2 , 5 , 10 , 15 or 20 % fbs , whereas the antifungal activities of ab and ame were similar .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
125,
135
]
}
|
{
"id": "C0002679",
"name": "ab",
"pos": [
150,
152
]
}
|
the effect of the antifungal drugs amphotericin b , fluocytosine , miconazole , griseofulvin , and nystatin on the chemotactic responsiveness of human neutrophils was studied .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
18,
28
]
}
|
{
"id": "C0002679",
"name": "amphotericin b",
"pos": [
35,
49
]
}
|
the effect of the antifungal drugs amphotericin b , fluocytosine , miconazole , griseofulvin , and nystatin on the chemotactic responsiveness of human neutrophils was studied .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
18,
28
]
}
|
{
"id": "C0025942",
"name": "miconazole",
"pos": [
67,
77
]
}
|
its antibacterial activity in vitro ( mic ) is similar , but its bactericidal efficacy superior to that of cephalexin and cephradine .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0007716",
"name": "cephalexin",
"pos": [
107,
117
]
}
|
its antibacterial activity in vitro ( mic ) is similar , but its bactericidal efficacy superior to that of cephalexin and cephradine .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0007738",
"name": "cephradine",
"pos": [
122,
132
]
}
|
the physicochemical and pharmacotoxicological properties , antifungal range , mechanisms of action , dosage and preparations of griseofulvin , amphotericin-b , natamycin , nystatin and pecilocin are discussed .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
59,
69
]
}
|
{
"id": "C0002679",
"name": "amphotericin-b",
"pos": [
143,
157
]
}
|
in vitro tests suggested that extensive use of parenteral gentamicin and replacement of the antibacterial topical cream sulfamylon by silver sulfadiazine favored the emergence of p. stuartii over pseudomonas aeruginosa as the predominant colonizing organism .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
92,
105
]
}
|
{
"id": "C0037134",
"name": "silver sulfadiazine",
"pos": [
134,
153
]
}
|
the in vitro antibacterial activity of four beta-lactam antibiotics ( cefatrizine [ bl-s640 ] , cefamandole , cefoxitin , and carbenicillin ) and three aminoglycosides ( amikacin , gentamicin , and tobramycin ) was determined against 197 strains of cephalothin-resistant enterobacteriaceae .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0007557",
"name": "cefoxitin",
"pos": [
110,
119
]
}
|
the in vitro antibacterial activity of four beta-lactam antibiotics ( cefatrizine [ bl-s640 ] , cefamandole , cefoxitin , and carbenicillin ) and three aminoglycosides ( amikacin , gentamicin , and tobramycin ) was determined against 197 strains of cephalothin-resistant enterobacteriaceae .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0006976",
"name": "carbenicillin",
"pos": [
126,
139
]
}
|
the in vitro antibacterial activity of four beta-lactam antibiotics ( cefatrizine [ bl-s640 ] , cefamandole , cefoxitin , and carbenicillin ) and three aminoglycosides ( amikacin , gentamicin , and tobramycin ) was determined against 197 strains of cephalothin-resistant enterobacteriaceae .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0002499",
"name": "amikacin",
"pos": [
170,
178
]
}
|
the in vitro antibacterial activity of four beta-lactam antibiotics ( cefatrizine [ bl-s640 ] , cefamandole , cefoxitin , and carbenicillin ) and three aminoglycosides ( amikacin , gentamicin , and tobramycin ) was determined against 197 strains of cephalothin-resistant enterobacteriaceae .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0040341",
"name": "tobramycin",
"pos": [
198,
208
]
}
|
the antibacterial activity of n1- ( 4,5-dimethyl-2-oxazolyl ) -sulfanilamide ( sulfamoxole ) and 2,4-diamino-5- ( 3,4,5-trimethoxy-benzyl ) -pyrimidine ( trimethoprim ) ( cn 3123 , nevin , supristol ) was studied in various bacterial infections in the fields of internal medicine , dermatology and gynecology .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0041041",
"name": "trimethoprim",
"pos": [
154,
166
]
}
|
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