text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
electroencephalographic ( eeg ) effects of lopramine , a new antidepressant , were investigated in rabbits with chronic electrode implants , and compared with those of imipramine and amitriptyline .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
61,
75
]
}
|
{
"id": "C0020934",
"name": "imipramine",
"pos": [
168,
178
]
}
|
electroencephalographic ( eeg ) effects of lopramine , a new antidepressant , were investigated in rabbits with chronic electrode implants , and compared with those of imipramine and amitriptyline .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
61,
75
]
}
|
{
"id": "C0002600",
"name": "amitriptyline",
"pos": [
183,
196
]
}
|
effect of culture media on the antifungal activity of miconazole and amphotericin b methyl ester .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
31,
41
]
}
|
{
"id": "C0025942",
"name": "miconazole",
"pos": [
54,
64
]
}
|
the capacity of four culture media to obfuscate the antifungal activity of miconazole and amphotericin b methyl ester was evaluated qualitatively by examination of five isolates each of candida albicans , candida tropicalis , candida parapsilosis , torulopsis glabrata , and cryptococcus neoformans , and quantitatively by determination of the absolute minimal inhibitory concentrations for a strain of c. albicans .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
52,
62
]
}
|
{
"id": "C0025942",
"name": "miconazole",
"pos": [
75,
85
]
}
|
the antifungal activity of amphotericin b methyl ester , like that of the parent compound amphotericin b , was not materially affected by the culture medium used for testing .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
4,
14
]
}
|
{
"id": "C0002679",
"name": "amphotericin",
"pos": [
90,
102
]
}
|
pharmacodynamics of the antiarrhythmic disopyramide in healthy humans : correlation of the kinetics of the drug and its effects .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
24,
38
]
}
|
{
"id": "C0012702",
"name": "disopyramide",
"pos": [
39,
51
]
}
|
in the past nine years , we have treated 11 patients who had an acute onset of hemiballismus believed to be the result of an acute vascular lesion with neuroleptic drugs ( most frequently haloperidol ) .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptic drugs",
"pos": [
152,
169
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
188,
199
]
}
|
both morphine and the neuroleptics , haloperidol and oxyperomide , dose-dependently reduce the aggression in rats produced by 20 mg/kg of apomorphine , a dopamine receptor stimulant .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptics",
"pos": [
22,
34
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
37,
48
]
}
|
twenty isolates of prototheca filamenta , prototheca moriformis , prototheca stagnora , prototheca wickerhamii , and prototheca zopfii were tested for in vitro susceptibility to five commonly used antifungal agents : amphotericin b , 5-fluorocytosine , griseofulvin , miconazole , and nystatin .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agents",
"pos": [
197,
214
]
}
|
{
"id": "C0002679",
"name": "amphotericin b",
"pos": [
217,
231
]
}
|
twenty isolates of prototheca filamenta , prototheca moriformis , prototheca stagnora , prototheca wickerhamii , and prototheca zopfii were tested for in vitro susceptibility to five commonly used antifungal agents : amphotericin b , 5-fluorocytosine , griseofulvin , miconazole , and nystatin .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agents",
"pos": [
197,
214
]
}
|
{
"id": "C0016278",
"name": "5-fluorocytosine",
"pos": [
234,
250
]
}
|
twenty isolates of prototheca filamenta , prototheca moriformis , prototheca stagnora , prototheca wickerhamii , and prototheca zopfii were tested for in vitro susceptibility to five commonly used antifungal agents : amphotericin b , 5-fluorocytosine , griseofulvin , miconazole , and nystatin .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agents",
"pos": [
197,
214
]
}
|
{
"id": "C0025942",
"name": "miconazole",
"pos": [
268,
278
]
}
|
the in vitro antibacterial activity of nine cephalosporins ( cephalothin , cephaloridine , cephalexin , cefazolin , cefamandole , cefuroxime , cefatrizine , cefoxitin , and cefazaflur ) was determined against 344 strains of enterobacteriaceae and 99 nonfermentative gram-negative bacilli .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0007716",
"name": "cephalexin",
"pos": [
91,
101
]
}
|
the in vitro antibacterial activity of nine cephalosporins ( cephalothin , cephaloridine , cephalexin , cefazolin , cefamandole , cefuroxime , cefatrizine , cefoxitin , and cefazaflur ) was determined against 344 strains of enterobacteriaceae and 99 nonfermentative gram-negative bacilli .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0007546",
"name": "cefazolin",
"pos": [
104,
113
]
}
|
the in vitro antibacterial activity of nine cephalosporins ( cephalothin , cephaloridine , cephalexin , cefazolin , cefamandole , cefuroxime , cefatrizine , cefoxitin , and cefazaflur ) was determined against 344 strains of enterobacteriaceae and 99 nonfermentative gram-negative bacilli .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0007562",
"name": "cefuroxime",
"pos": [
130,
140
]
}
|
the in vitro antibacterial activity of nine cephalosporins ( cephalothin , cephaloridine , cephalexin , cefazolin , cefamandole , cefuroxime , cefatrizine , cefoxitin , and cefazaflur ) was determined against 344 strains of enterobacteriaceae and 99 nonfermentative gram-negative bacilli .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0007557",
"name": "cefoxitin",
"pos": [
157,
166
]
}
|
septisol antiseptic foam ( 0.23 % hexachlorophene in a 46 % ethyl alcohol base ) is a new surgical scrub agent for both primary and re-entry use that is designed to minimize the harsh effects to the skin of the conventional scrub while retaining effective antibacterial properties .
|
therapeutic_class_of
|
{
"id": "C0003205",
"name": "antiseptic",
"pos": [
9,
19
]
}
|
{
"id": "C0019435",
"name": "hexachlorophene",
"pos": [
34,
49
]
}
|
in an 8-week surgical scrub study , equal effectiveness was shown between septisol antiseptic foam and a standard 3 % hexachlorophene detergent .
|
therapeutic_class_of
|
{
"id": "C0003205",
"name": "antiseptic",
"pos": [
83,
93
]
}
|
{
"id": "C0019435",
"name": "hexachlorophene",
"pos": [
118,
133
]
}
|
however , septisol antiseptic foam offers considerable advantage in minimizing the harsh effects to the skin of the conventional surgical scrub and results in a substantially lower hemic level of hexachlorophene in the user than that obtained with 3 % hexachlorophene detergent .
|
therapeutic_class_of
|
{
"id": "C0003205",
"name": "antiseptic",
"pos": [
19,
29
]
}
|
{
"id": "C0019435",
"name": "hexachlorophene",
"pos": [
252,
267
]
}
|
quantification of the antibacterial action of trimethoprim alone and in combination with sulfonamides by bacterial growth kinetics .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
22,
35
]
}
|
{
"id": "C0041041",
"name": "trimethoprim",
"pos": [
46,
58
]
}
|
analysis of in vitro antibacterial activities of the combination of trimethoprim and sulfamethoxazole on clinical isolates in japan .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
21,
34
]
}
|
{
"id": "C0041041",
"name": "trimethoprim",
"pos": [
68,
80
]
}
|
the action of antiepileptic drugs -- diphenylhydantoin and phenobarbital -- on enzymatic systems involved in the active transport of cations .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
14,
33
]
}
|
{
"id": "C0031507",
"name": "diphenylhydantoin",
"pos": [
37,
54
]
}
|
the effect of treatment with combinations of the two antifungal agents , 5-fluorocytosine ( 5-fc ) and amphotericin b ( ab ) , against systemic candida albicans infections in mice was investigated .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agents",
"pos": [
53,
70
]
}
|
{
"id": "C0016278",
"name": "5-fc",
"pos": [
92,
96
]
}
|
the effect of treatment with combinations of the two antifungal agents , 5-fluorocytosine ( 5-fc ) and amphotericin b ( ab ) , against systemic candida albicans infections in mice was investigated .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agents",
"pos": [
53,
70
]
}
|
{
"id": "C0002679",
"name": "amphotericin b",
"pos": [
103,
117
]
}
|
one member of this series , 1- ( 2-hydroxyethyl ) -3-nitro-4-pyrazolecarboxamide , exhibited an antibacterial spectrum similar to that of nitrofurantoin .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
96,
109
]
}
|
{
"id": "C0028156",
"name": "nitrofurantoin",
"pos": [
138,
152
]
}
|
it has been shown that thyrotropin releasing hormone ( trh ) can potentiate the effects of the antidepressant , imipramine , as measured by the mouse forced-swimming test .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
95,
109
]
}
|
{
"id": "C0020934",
"name": "imipramine",
"pos": [
112,
122
]
}
|
when high active doses of the antidepressants were used alone , only the clomipramine effect was blocked by naloxone .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
30,
45
]
}
|
{
"id": "C0009010",
"name": "clomipramine",
"pos": [
73,
85
]
}
|
[ experimental study of the action of antimalarial agents with respect to therapy in porphyria . combined effect of chloroquine and pyrimethamine ] .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "antimalarial agents",
"pos": [
38,
57
]
}
|
{
"id": "C0008269",
"name": "chloroquine",
"pos": [
116,
127
]
}
|
mexiletine and tocainide : a comparison of antiarrhythmic efficacy , adverse effects , and predictive value of lidocaine testing .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
43,
57
]
}
|
{
"id": "C0023660",
"name": "lidocaine",
"pos": [
111,
120
]
}
|
finally , although mexiletine provided effective antiarrhythmic therapy more often than tocainide , response to one lidocaine analogue did not predict response to the other .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
49,
63
]
}
|
{
"id": "C0023660",
"name": "lidocaine",
"pos": [
116,
125
]
}
|
five antimicrobial drugs ( ceftazidime , ciprofloxacin , imipenem , piperacillin and tobramycin ) and two human , intravenously applicable , igg immunoglobulin preparations ( psomaglobin , polyglobin n ) were examined alone and in various combinations for therapeutic efficacy in myelosuppressed as well as normal nmri mice following systemic infection with 4 selected strains of pseudomonas aeruginosa .
|
therapeutic_class_of
|
{
"id": "C1136254",
"name": "antimicrobial drugs",
"pos": [
5,
24
]
}
|
{
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
41,
54
]
}
|
fluconazole , a bis-triazole antifungal , is distinguished from imidazole antifungals ( e.g . ketoconazole ) by its potency and pharmacokinetic characteristics .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal",
"pos": [
29,
39
]
}
|
{
"id": "C0022625",
"name": "ketoconazole",
"pos": [
94,
106
]
}
|
about half of the nai tone villagers were given a broad spectrum antihelminthic ( albendazole ) , and the boh saen students were all treated successively with three drugs : piperazine citrate to treat for ascaris , pyrantel pamoate to treat for hookworm , and mebendazole to treat for trichuris .
|
therapeutic_class_of
|
{
"id": "C0003158",
"name": "antihelminthic",
"pos": [
65,
79
]
}
|
{
"id": "C0001911",
"name": "albendazole",
"pos": [
82,
93
]
}
|
about half of the nai tone villagers were given a broad spectrum antihelminthic ( albendazole ) , and the boh saen students were all treated successively with three drugs : piperazine citrate to treat for ascaris , pyrantel pamoate to treat for hookworm , and mebendazole to treat for trichuris .
|
therapeutic_class_of
|
{
"id": "C0003158",
"name": "antihelminthic",
"pos": [
65,
79
]
}
|
{
"id": "C0025023",
"name": "mebendazole",
"pos": [
260,
271
]
}
|
the antibacterial activities of pipc-analogues became stronger as the chain length of the alkyl group on the n-4 position in 2,3-dioxopiperazine when tested in constitutively beta-lactamase-producing strain , but not paralleled in wild and beta-lactamase-less strains .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0031955",
"name": "pipc-analogues",
"pos": [
32,
46
]
}
|
the in vitro antibacterial spectrum of l-658,310 , a new semisynthetic cephalosporin , was compared with ceftazidime , aztreonam and piperacillin against a wide variety of randomly selected human clinical isolates .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0007559",
"name": "ceftazidime",
"pos": [
105,
116
]
}
|
the in vitro antibacterial spectrum of l-658,310 , a new semisynthetic cephalosporin , was compared with ceftazidime , aztreonam and piperacillin against a wide variety of randomly selected human clinical isolates .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0004521",
"name": "aztreonam",
"pos": [
119,
128
]
}
|
the in vitro antibacterial spectrum of l-658,310 , a new semisynthetic cephalosporin , was compared with ceftazidime , aztreonam and piperacillin against a wide variety of randomly selected human clinical isolates .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0031955",
"name": "piperacillin",
"pos": [
133,
145
]
}
|
the effect of advancing age on the kinetics of the antiarrhythmic agent mexiletine was studied by comparing various kinetic parameters calculated after administration of a single oral dose of mexiletine hydrochloride to seven elderly and eight young healthy volunteers .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
51,
71
]
}
|
{
"id": "C0025887",
"name": "mexiletine",
"pos": [
192,
202
]
}
|
the potencies and efficacies of 9 quinoline-containing anti-malarials including chloroquine , ( bis ) desethylchloroquine , sn6911 , sn12108 , amodiaquine , cn-2999-2k , primaquine , quinacrine , and quinine were examined in vitro against adult female brugia pahangi .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "anti-malarials",
"pos": [
55,
69
]
}
|
{
"id": "C0008269",
"name": "chloroquine",
"pos": [
110,
121
]
}
|
the potencies and efficacies of 9 quinoline-containing anti-malarials including chloroquine , ( bis ) desethylchloroquine , sn6911 , sn12108 , amodiaquine , cn-2999-2k , primaquine , quinacrine , and quinine were examined in vitro against adult female brugia pahangi .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "anti-malarials",
"pos": [
55,
69
]
}
|
{
"id": "C0033126",
"name": "primaquine",
"pos": [
170,
180
]
}
|
in 13 dogs who received all four drug treatments ( mexiletine , quinidine , combination and placebo ) significantly greater antiarrhythmic efficacy was seen with combination therapy ( 8 of 13 ) than was seen with mexiletine alone ( 1 of 13 ) , quinidine alone ( 3 of 13 ) and saline ( 0 of 13 ) ( p less than .005 ) .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
124,
138
]
}
|
{
"id": "C0034414",
"name": "quinidine",
"pos": [
244,
253
]
}
|
these results show that isofloxythepin is a neuroleptic with h1-antagonist properties , which are intermediate in potency between those of chlorpromazine and haloperidol , and also it may have an inhibitory action on histamine turnover in the brain .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptic",
"pos": [
44,
55
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
158,
169
]
}
|
effects of an-132 , a novel antiarrhythmic lidocaine analogue , and of lidocaine on membrane ionic currents of guinea-pig ventricular myocytes .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
28,
42
]
}
|
{
"id": "C0023660",
"name": "lidocaine",
"pos": [
71,
80
]
}
|
various antidepressants ( imipramine , amitriptyline , citalopram , mianserin ) used in the behavioural despair test in mice , in doses which were not effective by themselves , increased the immobility-reducing effect when given jointly with 1,4-dihydropyridine calcium channel antagonists ( 5 mg/kg ) .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
8,
23
]
}
|
{
"id": "C0020934",
"name": "imipramine",
"pos": [
26,
36
]
}
|
various antidepressants ( imipramine , amitriptyline , citalopram , mianserin ) used in the behavioural despair test in mice , in doses which were not effective by themselves , increased the immobility-reducing effect when given jointly with 1,4-dihydropyridine calcium channel antagonists ( 5 mg/kg ) .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
8,
23
]
}
|
{
"id": "C0002600",
"name": "amitriptyline",
"pos": [
39,
52
]
}
|
results failed to support the anhedonia interpretation of neuroleptic-induced response decrements : pimozide did not diminish the ability of a high-concentration sucrose solution to maintain elevated response forces .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptic",
"pos": [
58,
69
]
}
|
{
"id": "C0031935",
"name": "pimozide",
"pos": [
100,
108
]
}
|
the findings strongly suggest that ethanol can prevent adaptive changes in the brain induced by chronic treatment with the antidepressant desipramine .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
123,
137
]
}
|
{
"id": "C0011685",
"name": "desipramine",
"pos": [
138,
149
]
}
|
we have demonstrated significant differences in 1,6-diphenyl-1,3,5-hexatriene fluorescence polarization values between lymphocyte membranes of untreated rheumatoid arthritis patients and lymphocyte membranes of patients treated with antirheumatic drugs , such as hydroxychloroquine and auranofin .
|
therapeutic_class_of
|
{
"id": "C0003191",
"name": "antirheumatic drugs",
"pos": [
233,
252
]
}
|
{
"id": "C0020336",
"name": "hydroxychloroquine",
"pos": [
263,
281
]
}
|
in studies investigating the modification of the response by antidepressant treatments both acute ( 3 day ) and chronic ( 22 day ) administration of the mao inhibitor clorgyline , as well as the tricyclics clomipramine and imipramine , attenuated the hyperthermic response to m-cpp .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
61,
75
]
}
|
{
"id": "C0009010",
"name": "clomipramine",
"pos": [
206,
218
]
}
|
in studies investigating the modification of the response by antidepressant treatments both acute ( 3 day ) and chronic ( 22 day ) administration of the mao inhibitor clorgyline , as well as the tricyclics clomipramine and imipramine , attenuated the hyperthermic response to m-cpp .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
61,
75
]
}
|
{
"id": "C0020934",
"name": "imipramine",
"pos": [
223,
233
]
}
|
in the primary screening , three well-known anthelmintics of the benzimidazol series , including fenbendazole , mebendazole and levamisol , were tested by the method of controlled test .
|
therapeutic_class_of
|
{
"id": "C0003158",
"name": "anthelmintics",
"pos": [
44,
57
]
}
|
{
"id": "C0025023",
"name": "mebendazole",
"pos": [
112,
123
]
}
|
piracetam ( 500 mg/kg orally ) , but not meclofenoxate ( 100 mg/kg orally ) potentiated the activating effect of antidepressants : pyrazidol , inkazane , nialamid and imipramine ( 10 mg/kg orally ) , in the `` '' behavioral escape '' '' test .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
113,
128
]
}
|
{
"id": "C0020934",
"name": "imipramine",
"pos": [
167,
177
]
}
|
single or repeated injections of cataleptogenic neuroleptic drugs ( haloperidol , metoclopramide ) caused nonuniform changes of the thresholds of rotation induced by putamen stimulation .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptic",
"pos": [
48,
59
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
68,
79
]
}
|
all patients continued to receive a type 1 antiarrhythmic drug or amiodarone throughout the period of transesophageal pacing .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic drug",
"pos": [
43,
62
]
}
|
{
"id": "C0002598",
"name": "amiodarone",
"pos": [
66,
76
]
}
|
the antibacterial spectrum of the novel glycopeptide was close to that of ristomycin and vancomycin .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
4,
17
]
}
|
{
"id": "C0042313",
"name": "vancomycin",
"pos": [
89,
99
]
}
|
however , the in vitro antibacterial activity of eremomycin was 2-10 times higher than that of ristomycin and vancomycin .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
23,
36
]
}
|
{
"id": "C0042313",
"name": "vancomycin",
"pos": [
110,
120
]
}
|
in the physiological range of concentrations of metabolites , 3ohq may contribute to the antiarrhythmic effect of quinidine in an additive way , but qno may have little effect when we take into account the fact that the free fraction of 3ohq is 2.5 times that of quinidine .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
89,
103
]
}
|
{
"id": "C0034414",
"name": "quinidine",
"pos": [
263,
272
]
}
|
to test the effect of trimethoprim ( an antibiotic commonly administered with sulfamethoxazole ) on the disposition of the antiarrhythmic procainamide hydrochloride and its active metabolite n-acetylprocainamide , 10 healthy men received 1 g of procainamide hydrochloride orally on two occasions , coadministered with placebo or trimethoprim ( 100 mg twice a day for 2 days before and then 200 mg with the procainamide dose ) .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
123,
137
]
}
|
{
"id": "C0600311",
"name": "procainamide hydrochloride",
"pos": [
245,
271
]
}
|
the effect of the antiepileptics valpromide and sodium valproate on the cytosolic epoxide hydrolase was studied in human fetal liver , kidneys and adrenals and from human adult liver and kidneys .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptics",
"pos": [
18,
32
]
}
|
{
"id": "C0037567",
"name": "sodium valproate",
"pos": [
48,
64
]
}
|
the in-vitro rate constants of the cellular uptake and elimination of the antimicrobial agents josamycin ( wilprafen ) , erythromycin and tetracycline were measured in normal human polymorphonuclear leucocytes ( pmns ) using the velocity gradient centrifugation technique with radiolabelled drugs at extracellular concentrations corresponding to therapeutically effective serum levels .
|
therapeutic_class_of
|
{
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
74,
94
]
}
|
{
"id": "C0014806",
"name": "erythromycin",
"pos": [
121,
133
]
}
|
the in-vitro rate constants of the cellular uptake and elimination of the antimicrobial agents josamycin ( wilprafen ) , erythromycin and tetracycline were measured in normal human polymorphonuclear leucocytes ( pmns ) using the velocity gradient centrifugation technique with radiolabelled drugs at extracellular concentrations corresponding to therapeutically effective serum levels .
|
therapeutic_class_of
|
{
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
74,
94
]
}
|
{
"id": "C0039644",
"name": "tetracycline",
"pos": [
138,
150
]
}
|
the in vitro antibacterial activity of aztreonam was compared with that of cefoperazone , cefotaxime , ceftazidime , gentamicin , latamoxef , and ticarcillin against 140 clinical isolates of gram-negative bacteria .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0004521",
"name": "aztreonam",
"pos": [
39,
48
]
}
|
the in vitro antibacterial activity of aztreonam was compared with that of cefoperazone , cefotaxime , ceftazidime , gentamicin , latamoxef , and ticarcillin against 140 clinical isolates of gram-negative bacteria .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0007552",
"name": "cefoperazone",
"pos": [
75,
87
]
}
|
the in vitro antibacterial activity of aztreonam was compared with that of cefoperazone , cefotaxime , ceftazidime , gentamicin , latamoxef , and ticarcillin against 140 clinical isolates of gram-negative bacteria .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0007554",
"name": "cefotaxime",
"pos": [
90,
100
]
}
|
the in vitro antibacterial activity of aztreonam was compared with that of cefoperazone , cefotaxime , ceftazidime , gentamicin , latamoxef , and ticarcillin against 140 clinical isolates of gram-negative bacteria .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0007559",
"name": "ceftazidime",
"pos": [
103,
114
]
}
|
the in vitro antibacterial activity of aztreonam was compared with that of cefoperazone , cefotaxime , ceftazidime , gentamicin , latamoxef , and ticarcillin against 140 clinical isolates of gram-negative bacteria .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
13,
26
]
}
|
{
"id": "C0040193",
"name": "ticarcillin",
"pos": [
146,
157
]
}
|
failure of the antiepileptic drug valproic acid to modify synaptic and non-synaptic responses of ca1 hippocampal pyramidal cells maintained 'in vitro ' .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
15,
33
]
}
|
{
"id": "C0042291",
"name": "valproic acid",
"pos": [
34,
47
]
}
|
the mechanisms of action of the antiepileptic drug valproic acid ( vpa ) were analyzed in 24 ca1 pyramidal neurons of the 'in vitro ' hippocampal slice by using standard intracellular recording techniques .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic drug",
"pos": [
32,
50
]
}
|
{
"id": "C0042291",
"name": "valproic acid",
"pos": [
51,
64
]
}
|
anti-arrhythmic agents ( ethmozine , ethacizine , quinidine , disopyramide , amiodarone ) , used extensively for the control of various heart rhythm disorders , as well as calcium antagonists ( verapamil were shown to have a calcium-blocking property .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "anti-arrhythmic agents",
"pos": [
0,
22
]
}
|
{
"id": "C0034414",
"name": "quinidine",
"pos": [
50,
59
]
}
|
anti-arrhythmic agents ( ethmozine , ethacizine , quinidine , disopyramide , amiodarone ) , used extensively for the control of various heart rhythm disorders , as well as calcium antagonists ( verapamil were shown to have a calcium-blocking property .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "anti-arrhythmic agents",
"pos": [
0,
22
]
}
|
{
"id": "C0012702",
"name": "disopyramide",
"pos": [
62,
74
]
}
|
anti-arrhythmic agents ( ethmozine , ethacizine , quinidine , disopyramide , amiodarone ) , used extensively for the control of various heart rhythm disorders , as well as calcium antagonists ( verapamil were shown to have a calcium-blocking property .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "anti-arrhythmic agents",
"pos": [
0,
22
]
}
|
{
"id": "C0002598",
"name": "amiodarone",
"pos": [
77,
87
]
}
|
the antimalarial agent chloroquine ( cq ) inhibits dna and rna polymerase and interferes with lysosomal function .
|
therapeutic_class_of
|
{
"id": "C0003374",
"name": "antimalarial agent",
"pos": [
4,
22
]
}
|
{
"id": "C0008269",
"name": "chloroquine",
"pos": [
23,
34
]
}
|
the most promising new antiepileptic drugs are oxcabazepine and vigabatrin , which should be made available to all neurologists .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic",
"pos": [
23,
36
]
}
|
{
"id": "C0048044",
"name": "vigabatrin",
"pos": [
64,
74
]
}
|
to investigate the effects of neuroleptics on plasma thyrotropin ( tsh ) concentrations , haloperidol tablets were administered orally to 34 normal male volunteers .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptics",
"pos": [
30,
42
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
90,
101
]
}
|
the sbt concentration in the prostatic tissue was high enough to enhance the antibacterial activity of cpz .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial",
"pos": [
77,
90
]
}
|
{
"id": "C0007552",
"name": "cpz",
"pos": [
103,
106
]
}
|
further , use of desethylamiodarone as an antiarrhythmic agent may not be devoid of the adverse effects associated with amiodarone .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic agent",
"pos": [
42,
62
]
}
|
{
"id": "C0002598",
"name": "amiodarone",
"pos": [
120,
130
]
}
|
trials of treatment with atropine or isopropylnoradrenaline derivatives++ were undertaken in group a , and in group b antiarrhythmic++ drugs were used ( beta-blockers , quinidine , isoptin etc ) .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
118,
132
]
}
|
{
"id": "C0034414",
"name": "quinidine",
"pos": [
169,
178
]
}
|
successful therapy in group 1 patients was achieved by beta blockers alone ( 7 patients ) , beta blockers plus type 1a antiarrhythmic drugs ( 9 patients ) , procainamide alone ( 2 patients ) , sotalol ( 3 patients ) and amiodarone ( 2 patients ) .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
119,
139
]
}
|
{
"id": "C0033216",
"name": "procainamide",
"pos": [
157,
169
]
}
|
successful therapy in group 1 patients was achieved by beta blockers alone ( 7 patients ) , beta blockers plus type 1a antiarrhythmic drugs ( 9 patients ) , procainamide alone ( 2 patients ) , sotalol ( 3 patients ) and amiodarone ( 2 patients ) .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
119,
139
]
}
|
{
"id": "C0037707",
"name": "sotalol",
"pos": [
193,
200
]
}
|
successful therapy in group 1 patients was achieved by beta blockers alone ( 7 patients ) , beta blockers plus type 1a antiarrhythmic drugs ( 9 patients ) , procainamide alone ( 2 patients ) , sotalol ( 3 patients ) and amiodarone ( 2 patients ) .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic drugs",
"pos": [
119,
139
]
}
|
{
"id": "C0002598",
"name": "amiodarone",
"pos": [
220,
230
]
}
|
fluconazole ( uk-49,858 ) , a new oral bistriazole antifungal agent , was compared with amphotericin b in the treatment of established systemic infection with candida albicans in normal and diabetic rats .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal agent",
"pos": [
51,
67
]
}
|
{
"id": "C0002679",
"name": "amphotericin b",
"pos": [
88,
102
]
}
|
the in vitro activity of the dual-action antibacterial agent ro 23-9424 was compared with those of cefotaxime , ceftazidime , ciprofloxacin , fleroxacin , imipenem , and amikacin against 358 aerobes and anaerobes .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial agent",
"pos": [
41,
60
]
}
|
{
"id": "C0007554",
"name": "cefotaxime",
"pos": [
99,
109
]
}
|
the in vitro activity of the dual-action antibacterial agent ro 23-9424 was compared with those of cefotaxime , ceftazidime , ciprofloxacin , fleroxacin , imipenem , and amikacin against 358 aerobes and anaerobes .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial agent",
"pos": [
41,
60
]
}
|
{
"id": "C0007559",
"name": "ceftazidime",
"pos": [
112,
123
]
}
|
the in vitro activity of the dual-action antibacterial agent ro 23-9424 was compared with those of cefotaxime , ceftazidime , ciprofloxacin , fleroxacin , imipenem , and amikacin against 358 aerobes and anaerobes .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial agent",
"pos": [
41,
60
]
}
|
{
"id": "C0020933",
"name": "imipenem",
"pos": [
155,
163
]
}
|
the in vitro activity of the dual-action antibacterial agent ro 23-9424 was compared with those of cefotaxime , ceftazidime , ciprofloxacin , fleroxacin , imipenem , and amikacin against 358 aerobes and anaerobes .
|
therapeutic_class_of
|
{
"id": "C0279516",
"name": "antibacterial agent",
"pos": [
41,
60
]
}
|
{
"id": "C0002499",
"name": "amikacin",
"pos": [
170,
178
]
}
|
interaction of the antiarrhythmics moracizine ( moricizine , ethmozine , ethm ) and ethacizine ( etha ) , the ethyl ester hydrochlorides of 10- ( 3-r-propionyl ) -phenothiazine-2-carbamic acid ( where r is morpholine or diethylamine , respectively ) , with muscarinic cholinergic alpha- and beta-adrenergic systems and histamine h1 receptors ( h1-r ) has been studied .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmics",
"pos": [
19,
34
]
}
|
{
"id": "C0079856",
"name": "moricizine",
"pos": [
48,
58
]
}
|
five patients needing antiarrhythmic treatment were given 10 d of oral propafenone treatment ( 450-900 mg/day ) .
|
therapeutic_class_of
|
{
"id": "C0003195",
"name": "antiarrhythmic",
"pos": [
22,
36
]
}
|
{
"id": "C0033429",
"name": "propafenone",
"pos": [
71,
82
]
}
|
despite the emergence of resistance to a number of antimicrobial agents , h. ducreyi remains susceptible to ceftriaxone , erythromycin , and ciprofloxacin .
|
therapeutic_class_of
|
{
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
51,
71
]
}
|
{
"id": "C0014806",
"name": "erythromycin",
"pos": [
122,
134
]
}
|
despite the emergence of resistance to a number of antimicrobial agents , h. ducreyi remains susceptible to ceftriaxone , erythromycin , and ciprofloxacin .
|
therapeutic_class_of
|
{
"id": "C1136254",
"name": "antimicrobial agents",
"pos": [
51,
71
]
}
|
{
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
141,
154
]
}
|
[ kleine-levin syndrome . the provocation of manic symptoms by an antidepressant and a therapeutic trial of carbamazepine ] .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressant",
"pos": [
66,
80
]
}
|
{
"id": "C0006949",
"name": "carbamazepine",
"pos": [
108,
121
]
}
|
anticonvulsant properties of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone ( alpha-emtbl ) were compared with those of the antiepileptic drugs ethosuximide ( esm ) and valproate ( vpa ) by testing their ability to block seizures in mice caused by maximal electroshock ( mes ) , pentylenetetrazol ( ptz ) , picrotoxin ( picro ) , bicuculline ( bic ) , methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate ( dmcm ) , n-methyl-d , l-aspartate ( nmda ) , aminophylline ( amph ) , strychnine ( str ) , beta-ethyl-beta-methyl-gamma-thiobutyrolactone ( beta-emtbl ) , and t-butylbicyclophosphorothionate ( tbps ) .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
126,
145
]
}
|
{
"id": "C0015043",
"name": "ethosuximide",
"pos": [
146,
158
]
}
|
one hundred and seventeen children had been exposed to antiepileptic drugs in utero : 48 to phenytoin monotherapy , 16 to carbamazepine monotherapy , 24 to barbiturates ( 23 in combination with other drugs ) , 27 to drug combinations including phenytoin and/or carbamazepine but not barbiturates , and 2 to other drugs .
|
therapeutic_class_of
|
{
"id": "C0003299",
"name": "antiepileptic drugs",
"pos": [
55,
74
]
}
|
{
"id": "C0031507",
"name": "phenytoin",
"pos": [
244,
253
]
}
|
therapeutic responsiveness to drugs effective against protozoa , namely pentamidine ( trypanosoma , leishmania , sp ) , trimethoprim-sulfamethoxazole ( isospora sp ) , pyrimethamine-sulfadiazine ( toxoplasma , plasmodium sp ) and nonresponsiveness to antifungal drugs such as amphotericin b and ketoconazole indicate characteristics similar to protozoa .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
251,
267
]
}
|
{
"id": "C0002679",
"name": "amphotericin b",
"pos": [
276,
290
]
}
|
therapeutic responsiveness to drugs effective against protozoa , namely pentamidine ( trypanosoma , leishmania , sp ) , trimethoprim-sulfamethoxazole ( isospora sp ) , pyrimethamine-sulfadiazine ( toxoplasma , plasmodium sp ) and nonresponsiveness to antifungal drugs such as amphotericin b and ketoconazole indicate characteristics similar to protozoa .
|
therapeutic_class_of
|
{
"id": "C0003308",
"name": "antifungal drugs",
"pos": [
251,
267
]
}
|
{
"id": "C0022625",
"name": "ketoconazole",
"pos": [
295,
307
]
}
|
reinstitution of neuroleptic treatment with molindone in a patient with a history of neuroleptic malignant syndrome .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptic",
"pos": [
17,
28
]
}
|
{
"id": "C0026388",
"name": "molindone",
"pos": [
44,
53
]
}
|
a case is reported in which neuroleptic treatment was successfully reintroduced with molindone after previous bouts of neuroleptic malignant syndrome ( nms ) with trifluoperazine and thioridazine .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptic",
"pos": [
28,
39
]
}
|
{
"id": "C0026388",
"name": "molindone",
"pos": [
85,
94
]
}
|
molindone may represent an alternative neuroleptic to consider in patients with a history of nms , although all neuroleptics including clozapine and molindone may potentially precipitate this syndrome .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptics",
"pos": [
112,
124
]
}
|
{
"id": "C0026388",
"name": "molindone",
"pos": [
149,
158
]
}
|
these results indicate that lisuride may be useful for the treatment of depression and indicate that a low dose of lisuride may enhance the clinical effectiveness of antidepressants such as desipramine .
|
therapeutic_class_of
|
{
"id": "C0003289",
"name": "antidepressants",
"pos": [
166,
181
]
}
|
{
"id": "C0011685",
"name": "desipramine",
"pos": [
190,
201
]
}
|
the presence or absence of neuroleptic-induced pseudoparkinsonism , the presence or absence of akathisia , and plasma levels of haloperidol are used to distinguish five types of haloperidol-resistant psychotic patients .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "neuroleptic",
"pos": [
27,
38
]
}
|
{
"id": "C0018546",
"name": "haloperidol",
"pos": [
178,
189
]
}
|
the antipsychotic drug molindone is considered to be atypical in its mode of action and to have mild side effects .
|
therapeutic_class_of
|
{
"id": "C0040615",
"name": "antipsychotic drug",
"pos": [
4,
22
]
}
|
{
"id": "C0026388",
"name": "molindone",
"pos": [
23,
32
]
}
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.