text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
enhancement of human neutrophil adherence by synthetic leukotriene constituents of the slow-reacting substance of anaphylaxis .
|
NA
|
{
"id": "C0023545",
"name": "leukotriene",
"pos": [
55,
66
]
}
|
{
"id": "C0038091",
"name": "of",
"pos": [
111,
113
]
}
|
the functionally predominant constituents of the slow-reacting substance of anaphylaxis ( srs-a ) , designated leukotrienes c4 and d4 ( ltc4 and ltd4 ) , as well as the leucocyte chemotactic factor leukotriene b4 ( ltb4 ) enhance the adherence of human neutrophils to sephadex g-25 .
|
NA
|
{
"id": "C0038091",
"name": "of",
"pos": [
42,
44
]
}
|
{
"id": "C0023544",
"name": "leukotrienes",
"pos": [
111,
123
]
}
|
a dialysable eosinophil chemotactic factor was isolated from the early stage ( 0-6 hr ) of local pca skin sites , and another chemotactic factor ( mol . wt . 15,000 ) , sharing a common antigenicity with guinea-pig serum c5 , from 12-hr-old local pca skin sites .
|
NA
|
{
"id": "C0008014",
"name": "eosinophil chemotactic factor",
"pos": [
13,
42
]
}
|
{
"id": "C0008013",
"name": "chemotactic factor",
"pos": [
126,
144
]
}
|
antibodies to this determinant were found not only in anti-kappa , but also in anti-lambda sera , and in antisera to hidden determinants of l-chains .
|
NA
|
{
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
}
|
{
"id": "C0020960",
"name": "antisera",
"pos": [
105,
113
]
}
|
upon in vivo virus replication , a different kind of antigenic variation was also detected in which an epitope lost its function in virus neutralization but kept its antigenic conformation unaltered .
|
NA
|
{
"id": "C0003316",
"name": "epitope",
"pos": [
103,
110
]
}
|
{
"id": "C0003320",
"name": "antigenic",
"pos": [
166,
175
]
}
|
the evoked tolerance was o-antigen specific since no pyrogenic tolerance against challenge with lipopolysaccharide from s. thompson ( possessing identical lipid a and core oligosaccharide structures but differing in the o-antigen polysaccharide chain ) could be seen ( p greater than 0.1 ) .
|
NA
|
{
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
96,
114
]
}
|
{
"id": "C0023767",
"name": "lipid a",
"pos": [
155,
162
]
}
|
the evoked tolerance was o-antigen specific since no pyrogenic tolerance against challenge with lipopolysaccharide from s. thompson ( possessing identical lipid a and core oligosaccharide structures but differing in the o-antigen polysaccharide chain ) could be seen ( p greater than 0.1 ) .
|
NA
|
{
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
96,
114
]
}
|
{
"id": "C0069180",
"name": "o-antigen",
"pos": [
220,
229
]
}
|
the evoked tolerance was o-antigen specific since no pyrogenic tolerance against challenge with lipopolysaccharide from s. thompson ( possessing identical lipid a and core oligosaccharide structures but differing in the o-antigen polysaccharide chain ) could be seen ( p greater than 0.1 ) .
|
NA
|
{
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
172,
187
]
}
|
{
"id": "C0032594",
"name": "polysaccharide",
"pos": [
230,
244
]
}
|
the endotoxins used were lipopolysaccharides from salmonella typhi , salmonella typhimurium , shigella flexneri and serratia marcescens .
|
NA
|
{
"id": "C0014264",
"name": "endotoxins",
"pos": [
4,
14
]
}
|
{
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
25,
44
]
}
|
adrenaline , noradrenaline , and phenylephrine ( 5 x 10 ( -7 ) - 5 x 10 ( -6 ) g/ml ) exhibited an excitatory effect on the mechanical activity .
|
NA
|
{
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
}
|
{
"id": "C0028351",
"name": "noradrenaline",
"pos": [
13,
26
]
}
|
des-n-tetramethyltriostin a can also interact with the purine nucleosides , but more preferentially with the adenosine derivative .
|
NA
|
{
"id": "C0034136",
"name": "purine",
"pos": [
55,
61
]
}
|
{
"id": "C0001443",
"name": "adenosine",
"pos": [
109,
118
]
}
|
synthesis of n alpha-9-fluorenylmethyloxycarbonyl ( fmoc ) amino-acids by reaction of free amino-acids ( glycine and alanine ) with 9-fluorenylmethylchloroformate leads to formation of small amounts of fmoc-dipeptide which are difficult to eliminate by crystallization .
|
NA
|
{
"id": "C0002520",
"name": "amino-acids",
"pos": [
59,
70
]
}
|
{
"id": "C0017890",
"name": "glycine",
"pos": [
105,
112
]
}
|
synthesis of n alpha-9-fluorenylmethyloxycarbonyl ( fmoc ) amino-acids by reaction of free amino-acids ( glycine and alanine ) with 9-fluorenylmethylchloroformate leads to formation of small amounts of fmoc-dipeptide which are difficult to eliminate by crystallization .
|
NA
|
{
"id": "C0002520",
"name": "amino-acids",
"pos": [
59,
70
]
}
|
{
"id": "C0001898",
"name": "alanine",
"pos": [
117,
124
]
}
|
the alternative way to prepare fmoc-amino-acids by reacting the fmoc-chloride first with sodium azide and then with the free amino-acid eliminates this side reaction , at least for glycine and alanine .
|
NA
|
{
"id": "C0002520",
"name": "amino-acid",
"pos": [
36,
46
]
}
|
{
"id": "C0017890",
"name": "glycine",
"pos": [
181,
188
]
}
|
the alternative way to prepare fmoc-amino-acids by reacting the fmoc-chloride first with sodium azide and then with the free amino-acid eliminates this side reaction , at least for glycine and alanine .
|
NA
|
{
"id": "C0002520",
"name": "amino-acid",
"pos": [
36,
46
]
}
|
{
"id": "C0001898",
"name": "alanine",
"pos": [
193,
200
]
}
|
the secretory tissue of the eye , the ciliary processes , contain an enzyme receptor complex , comprised by receptor complex , comprised by receptor bound membrane proteins , the catalytic moiety of the enzyme , a guanyl nucleotide regulatory protein ( or n protein ) and other features .
|
NA
|
{
"id": "C0026741",
"name": "enzyme",
"pos": [
69,
75
]
}
|
{
"id": "C0014442",
"name": "enzyme",
"pos": [
203,
209
]
}
|
the secretory tissue of the eye , the ciliary processes , contain an enzyme receptor complex , comprised by receptor complex , comprised by receptor bound membrane proteins , the catalytic moiety of the enzyme , a guanyl nucleotide regulatory protein ( or n protein ) and other features .
|
NA
|
{
"id": "C0025252",
"name": "membrane proteins",
"pos": [
155,
172
]
}
|
{
"id": "C0033684",
"name": "protein",
"pos": [
258,
265
]
}
|
- in plasma of the linoleic acid deficient animals the concentrations of tl , ch , che and tg were decreased .
|
NA
|
{
"id": "C0008377",
"name": "ch",
"pos": [
78,
80
]
}
|
{
"id": "C0008387",
"name": "che",
"pos": [
83,
86
]
}
|
- while the contents of tl , tg and che in the liver of the deficient rats increased significantly , those of pl and ch were hardly affected .
|
NA
|
{
"id": "C0008387",
"name": "che",
"pos": [
36,
39
]
}
|
{
"id": "C0008377",
"name": "ch",
"pos": [
117,
119
]
}
|
group ii : 10 patients with no known cardiac disease , but with non-specific ecg findings and/or mild cardiomegaly shown by x-ray .
|
NA
|
{
"id": "C0018799",
"name": "cardiac disease",
"pos": [
37,
52
]
}
|
{
"id": "C0018800",
"name": "cardiomegaly",
"pos": [
102,
114
]
}
|
the average age was 30 , and the most important clinical findings were pain ( 81.8 % ) , chills and fever ( 52.2 % ) and hepatomegaly ( 64.1 % ) .
|
NA
|
{
"id": "C0037088",
"name": "clinical findings",
"pos": [
48,
65
]
}
|
{
"id": "C0085593",
"name": "chills",
"pos": [
89,
95
]
}
|
it is reported that injection of the cyclic amp analog dibutyryl cyclic amp before light onset ( 1 ) completely blocked the light-induced burst of photoreceptor shedding seen at dawn in these fish ;
|
NA
|
{
"id": "C0001455",
"name": "cyclic amp",
"pos": [
37,
47
]
}
|
{
"id": "C0012054",
"name": "cyclic amp",
"pos": [
65,
75
]
}
|
these observations indicate that ( 1 ) the nii kinase can regulate rna polymerase i activity , ( 2 ) protein kinase nii is associated with the polymerase i enzyme complex , and ( 3 ) certain polypeptides of this enzyme complex may be the target antigens in rheumatic autoimmune disease .
|
NA
|
{
"id": "C0014442",
"name": "enzyme",
"pos": [
156,
162
]
}
|
{
"id": "C0026741",
"name": "enzyme complex",
"pos": [
212,
226
]
}
|
ddp as well as chip added on day 0 augmented the cmc response when spleen cells from c57bl/6 mice were cultured for 4 days with supraoptimal numbers of irradiated ( 4000 rads ) allogeneic p815 mastocytoma cells .
|
NA
|
{
"id": "C0007634",
"name": "cells",
"pos": [
74,
79
]
}
|
{
"id": "C3485979",
"name": "allogeneic",
"pos": [
177,
187
]
}
|
an intensive survey of radon and radon daughters concentrations in one predominantly igneous region is reported .
|
NA
|
{
"id": "C0034629",
"name": "radon",
"pos": [
23,
28
]
}
|
{
"id": "C0072962",
"name": "radon daughters",
"pos": [
33,
48
]
}
|
measurements of radon and radon daughters in 11 buildings in five states , using active or passive solar heating , showed no significant excess in concentrations over the levels measured in buildings with conventional heating systems .
|
NA
|
{
"id": "C0034629",
"name": "radon",
"pos": [
16,
21
]
}
|
{
"id": "C0072962",
"name": "radon daughters",
"pos": [
26,
41
]
}
|
by a linear programming procedure , we have optimized the jacobi room model to fit our data on the partitioning of radon daughters between air and wall surfaces ( plateout ) , obtained at high radon concentrations in a small chamber .
|
NA
|
{
"id": "C0072962",
"name": "radon daughters",
"pos": [
115,
130
]
}
|
{
"id": "C0034629",
"name": "radon",
"pos": [
193,
198
]
}
|
consideration of the equilibrium factor f between the concentration of the radon daughters and the concentration of radon is a part of the evaluation of the measurements of radon daughter concentrations in dwellings when applying limits .
|
NA
|
{
"id": "C0072962",
"name": "radon",
"pos": [
75,
80
]
}
|
{
"id": "C0034629",
"name": "radon",
"pos": [
173,
178
]
}
|
measurements of radon , radon daughters and air exchange rates have been carried out in 225 dwellings in sweden .
|
NA
|
{
"id": "C0034629",
"name": "radon",
"pos": [
16,
21
]
}
|
{
"id": "C0072962",
"name": "radon daughters",
"pos": [
24,
39
]
}
|
routine urine analyses and thyroid bioassays were performed during a period of several months to study the removal of 125i from the thyroid and to determine the effect potassium iodide had on the iodine-removal rate .
|
NA
|
{
"id": "C0032831",
"name": "potassium iodide",
"pos": [
168,
184
]
}
|
{
"id": "C0021966",
"name": "iodine",
"pos": [
196,
202
]
}
|
intermediate-sized filament proteins ( ifp ) are tissue specific in that antibodies to keratin , vimentin , desmin , glial fibrillary acidic protein ( gfap ) and the neurofilament proteins can distinguish between cells of epithelial and mesenchymal origin as well as of myogenic and neural origin respectively .
|
NA
|
{
"id": "C0021769",
"name": "intermediate",
"pos": [
0,
12
]
}
|
{
"id": "C0010803",
"name": "keratin",
"pos": [
87,
94
]
}
|
intermediate-sized filament proteins ( ifp ) are tissue specific in that antibodies to keratin , vimentin , desmin , glial fibrillary acidic protein ( gfap ) and the neurofilament proteins can distinguish between cells of epithelial and mesenchymal origin as well as of myogenic and neural origin respectively .
|
NA
|
{
"id": "C0021769",
"name": "intermediate",
"pos": [
0,
12
]
}
|
{
"id": "C0042666",
"name": "vimentin",
"pos": [
97,
105
]
}
|
intermediate-sized filament proteins ( ifp ) are tissue specific in that antibodies to keratin , vimentin , desmin , glial fibrillary acidic protein ( gfap ) and the neurofilament proteins can distinguish between cells of epithelial and mesenchymal origin as well as of myogenic and neural origin respectively .
|
NA
|
{
"id": "C0021769",
"name": "intermediate",
"pos": [
0,
12
]
}
|
{
"id": "C0017626",
"name": "glial fibrillary acidic protein",
"pos": [
117,
148
]
}
|
intermediate-sized filament proteins ( ifp ) are tissue specific in that antibodies to keratin , vimentin , desmin , glial fibrillary acidic protein ( gfap ) and the neurofilament proteins can distinguish between cells of epithelial and mesenchymal origin as well as of myogenic and neural origin respectively .
|
NA
|
{
"id": "C0021769",
"name": "intermediate",
"pos": [
0,
12
]
}
|
{
"id": "C0085418",
"name": "neurofilament proteins",
"pos": [
166,
188
]
}
|
the localization of this lectin may be specific for fucose in glycoproteins or other glycoconjugates , although this was not demonstrated here .
|
NA
|
{
"id": "C0017968",
"name": "glycoproteins",
"pos": [
62,
75
]
}
|
{
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
85,
100
]
}
|
most of the cells in menisci are chondrocytes but a few fibroblasts and cells of an intermediate form difficult to classify as either fibroblasts or chondrocytes also occur .
|
NA
|
{
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
}
|
{
"id": "C0016030",
"name": "fibroblasts",
"pos": [
134,
145
]
}
|
most of the cells in menisci are chondrocytes but a few fibroblasts and cells of an intermediate form difficult to classify as either fibroblasts or chondrocytes also occur .
|
NA
|
{
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
}
|
{
"id": "C0225369",
"name": "chondrocytes",
"pos": [
149,
161
]
}
|
edeine f is composed of amino acids : ( s ) -beta-phenyl-beta-alanine , ( s ) -isoserine , ( s ) -2,3-diaminopropionic acid , ( 2r,6s ) -diamino- ( 7r ) -hydroxyazelaic acid , glycine and a polyamine guanidylspermidine .
|
NA
|
{
"id": "C0002520",
"name": "amino",
"pos": [
24,
29
]
}
|
{
"id": "C0017890",
"name": "glycine",
"pos": [
176,
183
]
}
|
aclacinomycin a inhibited the in vitro conversion of phage phi x174 single-stranded dna to the replicative form dna .
|
NA
|
{
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
68,
87
]
}
|
{
"id": "C0012854",
"name": "dna",
"pos": [
112,
115
]
}
|
in ruminants , the primary metabolite of progesterone is pregnandiol and that of testosterone is epitestosterone .
|
NA
|
{
"id": "C0039601",
"name": "testosterone",
"pos": [
81,
93
]
}
|
{
"id": "C0014594",
"name": "epitestosterone",
"pos": [
97,
112
]
}
|
the metabolic fate of the anabolic agents , diethylstilbestrol , hexestrol , trenbolone acetate , zeranol and the endogenous steroids are discussed under the headings absorption , distribution and excretion .
|
NA
|
{
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
44,
62
]
}
|
{
"id": "C0019467",
"name": "hexestrol",
"pos": [
65,
74
]
}
|
however , there is rapid metabolism and excretion of anabolic agents with short half-lives in blood , and metabolic clearance rate equals entry rate .
|
NA
|
{
"id": "C0025519",
"name": "metabolism",
"pos": [
25,
35
]
}
|
{
"id": "C0221102",
"name": "excretion",
"pos": [
40,
49
]
}
|
tobramycin was the most active aminoglycoside ( mic 90:4 mg/l ) , complete cross resistance with gentamicin ( mic 90:8 mg/l ) was observed .
|
NA
|
{
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
31,
45
]
}
|
{
"id": "C0017436",
"name": "gentamicin",
"pos": [
97,
107
]
}
|
in order to identify type i cat among chloramphenicol resistant isolates , total cellular dna was probed with a 32p-labelled fragment of the cat structural gene from the transposable element tn9 .
|
NA
|
{
"id": "C0012854",
"name": "dna",
"pos": [
90,
93
]
}
|
{
"id": "C0012868",
"name": "transposable element",
"pos": [
170,
190
]
}
|
quantitation is carried out by using fluorescence detection combined with high pressure liquid chromatography ( hplc ) of aflatoxin m1 which has been converted to aflatoxin m2a with trifluoroacetic acid .
|
NA
|
{
"id": "C0085181",
"name": "aflatoxin m1",
"pos": [
122,
134
]
}
|
{
"id": "C0001734",
"name": "aflatoxin",
"pos": [
163,
172
]
}
|
glucose and sucrose in cereal samples , lactose in cheese , and ethanol in beer and wine were determined using enzyme electrodes .
|
NA
|
{
"id": "C0001962",
"name": "ethanol",
"pos": [
64,
71
]
}
|
{
"id": "C0004922",
"name": "beer",
"pos": [
75,
79
]
}
|
glucose and sucrose in cereal samples , lactose in cheese , and ethanol in beer and wine were determined using enzyme electrodes .
|
NA
|
{
"id": "C0001962",
"name": "ethanol",
"pos": [
64,
71
]
}
|
{
"id": "C0043188",
"name": "wine",
"pos": [
84,
88
]
}
|
in these mutants , the level of ppgpp during exponential growth is decreased about 10-fold , relative to that of rpob+ wild-type strains , such that a near normal partitioning of rna polymerase occurs with respect to stable rna ( rrna and trna ) gene activity .
|
NA
|
{
"id": "C0035668",
"name": "rna",
"pos": [
179,
182
]
}
|
{
"id": "C0035701",
"name": "rrna",
"pos": [
230,
234
]
}
|
in escherichia coli , seven of the commonly occurring amino acids are strong attractants : l-aspartate , l-serine , l-glutamate , l-alanine , l-asparagine , glycine , and l-cysteine , in order of decreasing effectiveness .
|
NA
|
{
"id": "C0002520",
"name": "amino acids",
"pos": [
54,
65
]
}
|
{
"id": "C0001898",
"name": "l-alanine",
"pos": [
130,
139
]
}
|
in escherichia coli , seven of the commonly occurring amino acids are strong attractants : l-aspartate , l-serine , l-glutamate , l-alanine , l-asparagine , glycine , and l-cysteine , in order of decreasing effectiveness .
|
NA
|
{
"id": "C0002520",
"name": "amino acids",
"pos": [
54,
65
]
}
|
{
"id": "C0017890",
"name": "glycine",
"pos": [
157,
164
]
}
|
ester cerebrosides isolated from whale brain were demonstrated to be a mixture of 6-o-acyl , 2-o-acyl , 4-o-acyl , and 3-o-acyl galactosyl ceramides in that order of content ( yasugi , e. , et al . ( 1982 ) j. biochem . 91 , 1121-1127 ) .
|
NA
|
{
"id": "C0007805",
"name": "cerebrosides",
"pos": [
6,
18
]
}
|
{
"id": "C0016960",
"name": "galactosyl ceramides",
"pos": [
128,
148
]
}
|
by these procedures , ester cerebrosides obtained from bovine and human brains were demonstrated to be not only 6-o-acyl and 3-o-acyl galactosyl ceramides but also 2-o-acyl and 4-o-acyl galactosyl ceramides similar to those of whale brain .
|
NA
|
{
"id": "C0007805",
"name": "cerebrosides",
"pos": [
28,
40
]
}
|
{
"id": "C0016960",
"name": "galactosyl",
"pos": [
186,
196
]
}
|
the selective and limited attack of the nucleolar rnase on native rna was similarly observed using mouse 45 s preribosomal rna as a substrate and possibly suggests a role for this nucleolar rnase in ribosomal rna processing .
|
NA
|
{
"id": "C0035668",
"name": "rna",
"pos": [
50,
53
]
}
|
{
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
199,
212
]
}
|
the 3'-termini of the mitochondrial 12 s and 16 s ribosomal rnas from mouse l cells have been definitively characterized by mobility-shift rna sequencing , rnase digestion followed by fingerprinting using two-dimensional homochromatography , and precise mapping of rna-dna duplexes using nuclease s1 .
|
NA
|
{
"id": "C0035701",
"name": "ribosomal rnas",
"pos": [
50,
64
]
}
|
{
"id": "C0035668",
"name": "rna",
"pos": [
265,
268
]
}
|
vanadate ( 0.1-5 mm ) inhibited the secondary cleavage of ca2+-atpase by trypsin suggesting that the susceptibility of the tryptic cleavage sites is influenced either by the conformation of the enzyme or by the formation of atpase crystals .
|
NA
|
{
"id": "C0001476",
"name": "ca2",
"pos": [
58,
61
]
}
|
{
"id": "C0001473",
"name": "atpase",
"pos": [
224,
230
]
}
|
the kinase also phosphorylates histone 2a , isolated smooth muscle light chains , and , to a very small extent , casein , but has no activity toward phosvitin or myosin ii , a third acanthamoeba myosin isoenzyme with a very different structure from myosin ia and ib .
|
NA
|
{
"id": "C0027103",
"name": "myosin ii",
"pos": [
162,
171
]
}
|
{
"id": "C0949646",
"name": "a",
"pos": [
259,
260
]
}
|
continuous treatment of cultured granulosa cells with fsh or with cyclic amp analogs ( dibutyryl cyclic amp or 8-bromo cyclic amp ) for 72 h increased incorporation of [ 35s ] methionine into immunoprecipitable cytochrome p-450scc .
|
NA
|
{
"id": "C0001455",
"name": "cyclic amp",
"pos": [
66,
76
]
}
|
{
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
87,
107
]
}
|
continuous treatment of cultured granulosa cells with fsh or with cyclic amp analogs ( dibutyryl cyclic amp or 8-bromo cyclic amp ) for 72 h increased incorporation of [ 35s ] methionine into immunoprecipitable cytochrome p-450scc .
|
NA
|
{
"id": "C0001455",
"name": "cyclic amp",
"pos": [
66,
76
]
}
|
{
"id": "C0000661",
"name": "8-bromo cyclic amp",
"pos": [
111,
129
]
}
|
two-dimensional peptide maps of tryptic digests of s6 from insulin-treated 3t3-l1 cells contain 5 phosphopeptides ;
|
NA
|
{
"id": "C0030956",
"name": "peptide",
"pos": [
16,
23
]
}
|
{
"id": "C0031684",
"name": "phosphopeptides",
"pos": [
98,
113
]
}
|
a slow reacting substance of anaphylaxis antagonist , fpl 55712 , which , in some systems , distinguishes ltc4- from ltd4-induced contractions , was a weak competitor with a ki of 16 microm .
|
NA
|
{
"id": "C0038091",
"name": "slow reacting substance of anaphylaxis",
"pos": [
2,
40
]
}
|
{
"id": "C0023542",
"name": "ltc4",
"pos": [
106,
110
]
}
|
a slow reacting substance of anaphylaxis antagonist , fpl 55712 , which , in some systems , distinguishes ltc4- from ltd4-induced contractions , was a weak competitor with a ki of 16 microm .
|
NA
|
{
"id": "C0038091",
"name": "slow reacting substance of anaphylaxis",
"pos": [
2,
40
]
}
|
{
"id": "C0023544",
"name": "ltd4",
"pos": [
117,
121
]
}
|
however , in clotting assays using factor xi-deficient plasma in the presence of kaolin , the light chain was only 1 % as active as native factor xia .
|
NA
|
{
"id": "C0015522",
"name": "factor xi",
"pos": [
35,
44
]
}
|
{
"id": "C0015524",
"name": "factor xia",
"pos": [
139,
149
]
}
|
when this radiolabeled factor ix was mixed with factor xia , an excellent correlation was observed between the appearance of factor ixa clotting activity and tritiated activation peptide that was soluble in cold trichloroacetic acid .
|
NA
|
{
"id": "C0015491",
"name": "factor ix",
"pos": [
23,
32
]
}
|
{
"id": "C0015494",
"name": "factor ixa clotting",
"pos": [
125,
144
]
}
|
the products of this reaction were purified by repeated anion exchange column chromatography and were found to consist of adenine deoxyribonucleotides methylated on the base moiety , terminal phosphate , or both .
|
NA
|
{
"id": "C0003075",
"name": "anion",
"pos": [
56,
61
]
}
|
{
"id": "C0031603",
"name": "phosphate",
"pos": [
192,
201
]
}
|
since one-third of the amino acid residues in collagen are glycines , we have labeled : ( a ) reconstituted lathrytic ( uncross-linked ) chick calvaria collagen fibrils ;
|
NA
|
{
"id": "C0002520",
"name": "amino acid",
"pos": [
23,
33
]
}
|
{
"id": "C0017890",
"name": "glycines",
"pos": [
59,
67
]
}
|
incorporation of [ methyl-3h ] methionine into rrna was rapidly inhibited and pulse-chase experiments indicated that 28 s rna was not synthesized after 24 h of exposure to dexamethasone .
|
NA
|
{
"id": "C0035701",
"name": "rrna",
"pos": [
47,
51
]
}
|
{
"id": "C0035668",
"name": "rna",
"pos": [
122,
125
]
}
|
in the presence of substrates with a high ratio of single-stranded dna template to either dna or rna primar , c1c2 increased the rate of dna synthesis by decreasing the km for the dna substrate , decreasing the km for the primer itself , increasing the use of shorter primers , and stimulating incorporation of the first deoxyribonucleotide .
|
NA
|
{
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
51,
70
]
}
|
{
"id": "C0012854",
"name": "dna",
"pos": [
180,
183
]
}
|
among other 14 acyl-coas tested , only propionyl-coa could substitute for acetyl-coa , as an acyl donor , with a reaction rate 4.3 % of that with acetyl-coa at 0.5 mm .
|
NA
|
{
"id": "C0001374",
"name": "acyl-coas",
"pos": [
15,
24
]
}
|
{
"id": "C0001026",
"name": "acetyl-coa",
"pos": [
146,
156
]
}
|
among amino acids other than l-glutamate and derivatives or analogues of glutamate tested , the following served as an acyl acceptor : glycine at a rate 2.7 % of that with l-glutamate at 1.0 mm , l-glutamine ( 5.0 % ) , l-glutamate gamma-hydroxamate ( 15.5 % ) , dl-alpha-aminoadipate ( 5.2 % ) , and dl-alpha-aminopimelate ( 4.0 % ) .
|
NA
|
{
"id": "C0002520",
"name": "amino acids",
"pos": [
6,
17
]
}
|
{
"id": "C0017890",
"name": "glycine",
"pos": [
135,
142
]
}
|
poly ( dit ) is the most active template , whereas a variety of single-stranded dna templates are 10-15 % as active and double-stranded dna templates are 10-15 % as active and double-stranded dna is less than 1 % .
|
NA
|
{
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
64,
83
]
}
|
{
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
176,
195
]
}
|
a gas chromatography/mass spectrometry analysis of the composition of the free fatty acids of the submaxillary gland of male mice showed that the mixture of fatty acids extracted from the gland was significantly different from the mixture of free fatty acids extracted from renin a .
|
NA
|
{
"id": "C0015684",
"name": "fatty acids",
"pos": [
79,
90
]
}
|
{
"id": "C0015688",
"name": "free fatty acids",
"pos": [
242,
258
]
}
|
the renin-extracted fatty acids were relatively richer in saturated fatty acids , like myristic and palmitic acids , and poorer in polyunsaturated fatty acids , like linoleic and arachidonic acid , than the free fatty acids of the gland .
|
NA
|
{
"id": "C0015684",
"name": "fatty acids",
"pos": [
20,
31
]
}
|
{
"id": "C0030235",
"name": "palmitic acids",
"pos": [
100,
114
]
}
|
the renin-extracted fatty acids were relatively richer in saturated fatty acids , like myristic and palmitic acids , and poorer in polyunsaturated fatty acids , like linoleic and arachidonic acid , than the free fatty acids of the gland .
|
NA
|
{
"id": "C0015684",
"name": "fatty acids",
"pos": [
20,
31
]
}
|
{
"id": "C0015688",
"name": "free fatty acids",
"pos": [
207,
223
]
}
|
the purified toxin was found to be a single polypeptide chain of 582 amino acids ( mr = 63,000 ) free of carbohydrate , with alanine as nh2-terminal amino acid .
|
NA
|
{
"id": "C0001898",
"name": "alanine",
"pos": [
125,
132
]
}
|
{
"id": "C0002520",
"name": "amino acid",
"pos": [
149,
159
]
}
|
three sets of mixed tetradecamer oligonucleotides were synthesized based on amino acid sequences in the 108-amino acid cell attachment domain ( pierschbacher , m. d. , ruoslahti , e. , sundelin , j. , lind , p. , and peterson , p. a . ( 1982 ) j. biol . chem . 257 , 9593-9597 ) .
|
NA
|
{
"id": "C0301714",
"name": "based",
"pos": [
67,
72
]
}
|
{
"id": "C0002520",
"name": "amino",
"pos": [
108,
113
]
}
|
an analog of gtp , 5'-p-fluorosulfonylbenzoyl guanosine ( 5'-p-fso2bzguo ) , appears to interact irreversibly with guanine nucleotide-binding sites on human platelet membranes .
|
NA
|
{
"id": "C0018353",
"name": "gtp",
"pos": [
13,
16
]
}
|
{
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
115,
133
]
}
|
at a given mg2+ concentration , atp and the guanyl nucleotides gtp and guanyl 5'-yl-imidodiphosphate ( gmp-p ( nh ) p ) caused a dose-dependent increase in adenylyl cyclase activity .
|
NA
|
{
"id": "C0018353",
"name": "gtp",
"pos": [
63,
66
]
}
|
{
"id": "C0018366",
"name": "guanyl 5",
"pos": [
71,
79
]
}
|
two distinct sets of phosphoproteins were identified among the seven affected by trh : set i , five proteins whose phosphorylation was increased only by agents which stimulated prl synthesis ;
|
NA
|
{
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
21,
36
]
}
|
{
"id": "C0033684",
"name": "proteins",
"pos": [
100,
108
]
}
|
recognition of the termination codon by release factor was studied with 70 s ribosomes containing initiator trna at the p site and an amino acid-specifying codon as well as the corresponding cognate trna at the a site .
|
NA
|
{
"id": "C0242611",
"name": "termination codon",
"pos": [
19,
36
]
}
|
{
"id": "C0009221",
"name": "codon",
"pos": [
156,
161
]
}
|
in vitro termination was not excluded when either the a site was occupied with an amino acid-specifying codon or the termination codon was displaced from the a site codon position by spacer nucleotides between uaa and the p site bound aug .
|
NA
|
{
"id": "C0242611",
"name": "termination codon",
"pos": [
117,
134
]
}
|
{
"id": "C0009221",
"name": "codon",
"pos": [
165,
170
]
}
|
the release factor may have flexibility in its codon recognizing domain to be able to adjust to this enforced change in the position of the termination codon on the ribosome without loss of functional specificity .
|
NA
|
{
"id": "C0009221",
"name": "codon",
"pos": [
47,
52
]
}
|
{
"id": "C0242611",
"name": "termination codon",
"pos": [
140,
157
]
}
|
addition of several arginine-specific serine proteases to culture medium conditioned by fibroblasts results in the proteases being taken into sodium dodecyl sulfate-stable complexes with a secreted factor termed protease nexin ( pn ) ( baker , j. b. , low , d. a. , simmer , r. l. , and cunningham , d. d. ( 1980 ) cell 21 , 37-45 ) .
|
NA
|
{
"id": "C0016030",
"name": "fibroblasts",
"pos": [
88,
99
]
}
|
{
"id": "C0007634",
"name": "cell",
"pos": [
315,
319
]
}
|
the essentially homogeneous preparations of the 7-hydroxylase were shown to catalyze the thymine- , 5-hydroxymethyluracil- , and 5-formyluracil-dependent oxygenations that are coupled to the decarboxylation of alpha-ketoglutarate , as well as a putative uncoupled decarboxylation which is dependent on uracil .
|
NA
|
{
"id": "C0040087",
"name": "thymine",
"pos": [
89,
96
]
}
|
{
"id": "C0041917",
"name": "uracil",
"pos": [
302,
308
]
}
|
escherichia coli glycyl-trna synthetase is one of two aminoacyl-trna synthetases which is comprised of two different subunits ( in an alpha 2 beta 2 structure ) .
|
NA
|
{
"id": "C0017983",
"name": "glycyl-trna synthetase",
"pos": [
17,
39
]
}
|
{
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
54,
80
]
}
|
we have observed that the synthesis and secretion of apo-e , a component of plasma lipoproteins , are suppressed in mouse macrophages exposed to bacterial lipopolysaccharide endotoxin ( lps ) in culture or in vivo .
|
NA
|
{
"id": "C0014264",
"name": "bacterial",
"pos": [
145,
154
]
}
|
{
"id": "C0023810",
"name": "lps",
"pos": [
186,
189
]
}
|
because apo-e serves as a recognition determinant for the receptor-mediated clearance of lipoproteins , the decreased synthesis of apo-e after lps treatment may in part explain the hyperlipoproteinemia associated with endotoxins in vivo .
|
NA
|
{
"id": "C0023810",
"name": "lps",
"pos": [
143,
146
]
}
|
{
"id": "C0014264",
"name": "endotoxins",
"pos": [
218,
228
]
}
|
however the binding was sensitive to the percentage of gel-state lipid in the vesicles , and the amount of apolipoprotein in the recombinant lipoprotein complex decreased as the percentage of fully saturated phospholipid was reduced .
|
NA
|
{
"id": "C0023779",
"name": "lipid",
"pos": [
65,
70
]
}
|
{
"id": "C0023820",
"name": "lipoprotein",
"pos": [
141,
152
]
}
|
when the photoaffinity labeled mr approximately equal to 62,000 peptides from the beta 2-adrenergic receptors of rat lung and erythrocyte are subjected to simultaneous proteolysis using staphylococcus aureus v8 proteinase or papain , exactly the same peptide fragments are generated from each subunit .
|
NA
|
{
"id": "C0030956",
"name": "peptides",
"pos": [
64,
72
]
}
|
{
"id": "C0030935",
"name": "peptide fragments",
"pos": [
251,
268
]
}
|
in contrast , when the mr approximately equal to 62,000 peptide containing the beta 1-adrenergic receptor-binding subunit derived from the rat heart is proteolyzed simultaneously with the mr approximately equal to 62,000 peptide containing the beta 2-adrenergic receptors from either lung or erythrocyte , the peptide fragments generated are distinctly different .
|
NA
|
{
"id": "C0030956",
"name": "peptide",
"pos": [
56,
63
]
}
|
{
"id": "C0030935",
"name": "peptide fragments",
"pos": [
310,
327
]
}
|
treatment of growing rous sarcoma virus-transformed chinese hamster ovary cells with the cyclic amp analog 8-bromo-cyclic adenosine 3',5'-monophosphate ( 8-bromo-cyclic amp ) stimulates the incorporation of 32pi into the viral transforming protein pp60src .
|
NA
|
{
"id": "C0001455",
"name": "cyclic amp",
"pos": [
89,
99
]
}
|
{
"id": "C0000661",
"name": "8-bromo-cyclic amp",
"pos": [
154,
172
]
}
|
we further demonstrated that several inactive derivatives of phorbol ester failed to cause an increase in phosphorylation of pp17 and pp27 , suggesting that these specific phosphorylation events are intimately related to the induction of differentiation in hl-60 cells by pma .
|
NA
|
{
"id": "C0031586",
"name": "phorbol ester",
"pos": [
61,
74
]
}
|
{
"id": "C0039654",
"name": "pma",
"pos": [
272,
275
]
}
|
a phosphorus-containing metabolite that accounts for up to 80 % of the total phosphate in perchloric acid extracts of methanobacterium thermoautotrophicum atcc 29183 was purified by chromatography on an anion exchange column .
|
NA
|
{
"id": "C0031603",
"name": "phosphate",
"pos": [
77,
86
]
}
|
{
"id": "C0003075",
"name": "anion",
"pos": [
203,
208
]
}
|
human factor xii was activated by limited proteolysis with trypsin , and the resulting beta-factor xiia ( mr = 30,000 ) was isolated by deae-sephacel column chromatography .
|
NA
|
{
"id": "C0015525",
"name": "factor xii",
"pos": [
6,
16
]
}
|
{
"id": "C0015527",
"name": "factor xiia",
"pos": [
92,
103
]
}
|
the amino acid sequence of the heavy chain shows a high degree of homology to the corresponding regions of other plasma serine proteases , such as plasmin , thrombin , factor ixa and factor xa , as well as the pancreatic digestive enzymes .
|
NA
|
{
"id": "C0036734",
"name": "serine proteases",
"pos": [
120,
136
]
}
|
{
"id": "C0016016",
"name": "plasmin",
"pos": [
147,
154
]
}
|
human chorionic gonadotropin ( hcg ) increased testosterone production in vitro while time course studies indicated a biphasic action of the gonadotropin on 3 beta-hydroxysteroid dehydrogenase activity .
|
NA
|
{
"id": "C0018062",
"name": "human chorionic",
"pos": [
0,
15
]
}
|
{
"id": "C0018061",
"name": "gonadotropin",
"pos": [
141,
153
]
}
|
accumulation of phosphate into iov in the presence of ca2+ is virtually abolished by prior dids treatment , consistent with the presumed inhibition of the band iii anion-exchange protein by this agent .
|
NA
|
{
"id": "C0031603",
"name": "phosphate",
"pos": [
16,
25
]
}
|
{
"id": "C0003075",
"name": "anion",
"pos": [
164,
169
]
}
|
lipophilic anions incapable of transporting protons into the vesicle interior ( nitrate and thiocyanate ) support sustained uptake only when the protonophore carbonyl cyanide p-trifluoromethoxyphenylhydrazone is also added .
|
NA
|
{
"id": "C0003075",
"name": "anions",
"pos": [
11,
17
]
}
|
{
"id": "C0028125",
"name": "nitrate",
"pos": [
80,
87
]
}
|
band iii protein appears to promote ca2+ transport in the presence of phosphate , sulfate , or chloride by exchanging external anion for the accumulating oh- ( or hco3- ) produced by the calcium pump .
|
NA
|
{
"id": "C0038720",
"name": "sulfate",
"pos": [
82,
89
]
}
|
{
"id": "C0003075",
"name": "anion",
"pos": [
127,
132
]
}
|
band iii protein appears to promote ca2+ transport in the presence of phosphate , sulfate , or chloride by exchanging external anion for the accumulating oh- ( or hco3- ) produced by the calcium pump .
|
NA
|
{
"id": "C0008203",
"name": "chloride",
"pos": [
95,
103
]
}
|
{
"id": "C0003075",
"name": "anion",
"pos": [
127,
132
]
}
|
reaction velocity on human collagen types i-iii in solution was slowed 15-35 % ( kh/kd = 1.2-1.5 ) by the substitution of deuterium for hydrogen in the solvent buffer .
|
NA
|
{
"id": "C0011744",
"name": "deuterium",
"pos": [
122,
131
]
}
|
{
"id": "C0020275",
"name": "hydrogen",
"pos": [
136,
144
]
}
|
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