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superstition material religion and hıdrellez in turkey
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this project will investigate the history of turkey in terms of religion rather than islam to understand the roots of the normative understanding of religiosity as sunniislamic the aim is to comprehend the western influence on religion and islam in turkey and to illuminate the history of material forms of religiosity by focusing on hıdrellez a religious practice that was and still is celebrated in a convivial manner by people of different ethnic and religious backgrounds while recent critical approaches in global religious history and material religion aim to overcome any eurocentrism that still persists in religious studies the case of turkey still remains largely unexplored situated at the intersection of religious studies and history this project will break new ground by bringing together a postcolonial history of superstition with the historical analysis of material religion and will advance global debates on how religion is discussed today through its critique of essentialist definitions of muslim majority nations the research objectives are 1 to examine the role of superstition in the categorisation of islam during the 1950s as a form of global entanglement between turkey and the west 2 to investigate the research on the history of religions and superstitions as a form of entanglement between turkey and germany 3 to empirically analyse the history of the diversity of religious life by focusing on hıdrellez 4 to analyse the transformation of hıdrellez from a religious practice to intangible cultural heritage superstitious will generate international collaborations and foster vibrant cooperation between scientific communities civil society representatives and citizens in the early years of the second centenary of the republic of türkiye it intends to lay the foundations for an awareness of religious pluralism and tolerance among its citizens and diaspora communities
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eosc track implementing the european open science monitoring mechanism
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eosc track will develop and operate the european open science observatory a policy intelligence tool that will monitor policies investments digital research outputs skills and infrastructure capacities related to the open science and the european open science cloud eosc its mission is to simplify and streamline monitoring in the european open science ecosystem to bring a common understanding on how to collect and interpret data appropriate for monitoring as well as to assist policymakers and research executives across europe in understanding shaping and aligning open science and related policies and their implementationstarting from the current eosc observatory developed during the eosc future project trl7 eosc track will transform the service into trl9 making it an open secure and trusted platform to serve as the goto place for open science monitoring europe it will enhance it with features to improve usability engagement and collaboration automate data ingestion from trusted sources such as the openaire graph incorporate collaborative editing and validation of data add interactive navigation and search visualisations it will complement with the eos resources registry which will serve as a learning tool by including narratives from experts to demonstrate the internal processes towards the os implementation in a country and stories for impact or best practiceeosc track will explore the sustainability of the eos observatory by fostering a codesign process with the eosc tripartite partnership and other interested stakeholders the objective is to align various monitoring initiatives offer practical assistance in data collection and generate 360o reports to establish a defacto hub for all information around monitoring open science and eosc in europe fast forwarding to 2027 eosc track will facilitate a dialogue with the eosc tripartite governance to develop a roadmap for ensuring longterm sustainability
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quantum information science and ultrafast nonlinear coherent control at the attosecond timescale
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understanding the interaction between electromagnetic radiation and matter is crucial for unravelling the internal structure and processes of materials electromagnetic waves exhibit both wavelike and particlelike behaviour with the quantized nature of light becoming apparent in the realm of quantum technologies the quatto network aims to merge the fields of quantum optics and quantum information science with attosecond physics this involves focusing on experimental campaigns to highlight quantum aspects in the interaction of intense laser fields with matter and advancing theoretical descriptions for a comprehensive understanding of the quantum state of light associated with intense laser fields traditionally attosecond pulses have been generated using tabletop femtosecond lasers however recent experiments performed at freeelectron lasers fels have demonstrated the production of isolated attosecond pulses and precise control of attosecond waveforms for pulse trains leading to remarkable advancements in attosecond science the network also aims to leverage recent advances in seeded fels and highintensity highharmonic generation hhgbased attosecond sources to demonstrate the coherent control of electronic dynamics in systems of increasing complexity the quatto network represents a comprehensive effort to advance the understanding and control of the interaction between electromagnetic radiation and matter with a specific focus on merging quantum optics quantum information science attosecond physics and freeelectron laser science the doctoral candidates dcs in the network will receive multifaceted scientific training encompassing experimental and theoretical aspects of quantum information science strongfield physics and soft xray and xray science as well as extensive training in transferable skills and selfmanagement techniques
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cold organic chemistry
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this proposal ventures into organic chemical reactions under notsocommon conditions namely in the cold at insufficient energies and under the action of hard radiation as many organic molecules have been discovered in space or brought to earth in meteorites they must have formed under such conditions through hitherto largely undisclosed mechanisms one key hypothesis is that quantummechanical tunneling qmt and novel reactions with exceptionally low barriers are at work hence one of the key objectives is to uncover how qmt where reactions occur through and not over barriers controls chemical reactivity and selectivity a second goal is the examination of cryogenic reactions of hydroxycarbenes or enols with carbonyl compounds our methods include organic synthesis of starting materials also isotopically labelled and products infrared as well as ultavioletvisible matrixisolation spectroscopy ab initio computations of structures spectra and potential energy surfaces as well as qmt rate calculations we will examine isotopeselective reactions of competing qmt reactions that can be made selective through strategic isotope incorporation qmt also offers new ways to activate carbon dioxide and even to catalyze reactions we propose a unifying synthesis of carbohydrates and alphaamino acids through a common mechanistic scenario namely a newly discovered heterocarbonylene reaction of carbenes or enols in the gas phase finally chemistry far from thermodynamic equilibrium is explored with probing the activation and reaction of highly stable molecules under irradiation with energetic electrons thereby mimicking conditions of the interstellar medium exposed to galactic cosmic rays this should shed light on the formation of larger complex organic molecules found in this medium and often considered as building blocks for life
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animal abidings recovering from disasters in morethanhuman communities
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what and how can we learn from animals about recovering from disasters how can we hear them in their own terms translate their stories and include their perspectives in human knowledge about disasters this project explores the resilience of multispecies communities and their capacities for healing and bouncing back from disasters through the point of view of nonhuman animals it departs from the current context of acute climate crisis which sets the stage for dantesque scenarios of impending climatedriven disasters such as wildfires floods tornados and hurricanes with related extensive loss of both human and nonhuman lives liveable dwellings and species extinction focusing on wildfires as disasters that challenge previous expert knowledge due to climate change and human exploitation of natural resources we propose to compare three countries where wildfires have taken on increasingly critical proportions every year brazil australia and portugal we address a species gap in our knowledge of disasters and wildfires in particular by exploring the possibilities of learning with animals how to live and cope with extreme change and uncertainty in wildfireprone areas drawing on contributions from sociologists anthropologists ethologists biologists and geographers abide aims at attuning to translating and including the voices stories and experiences of animals into our knowledge of how multispecies communities can better recover from the traumatic experience of wildfires in the end we seek to build the foundations for a new interdisciplinary framework for addressing humans and animals ability to build and abide in multispecies communities that are more resilient to wildfires and other disasters in so doing we aspire to identify the landmarks of a postspecies episteme and thus push forward the frontiers of knowledge of humananimal relations as well as contribute to a morethanhuman governance of disasters
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releaf paper breakthrough technology for sustainable production of leavesbased fibre disrupting paper production and eco packaging industries
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releaf paper is the first and the only producer of cellulose from fallen leaves in the world with a patent for the technology based on a unique method of combining mechanical chemical and thermal processes using standard equipment and a special drying procedure which allows obtaining a solid durable cellulose fibre for paper productionreleafs approach provides a solution of mass cutting trees for paper production and reduces co2 emissions by 78 in comparison with traditional paper productionreleafs paper production is sustainable at all stages of the production process 1sulphatesulphitefree reagents are used 2the process requires 15 times less water and 3 times less electricity 3paper products may be recycled up to 5 times without loss of quality or decomposed within 3060 daysthis solution is also costefficient due to the availability of raw materials and resourceefficient production thus the price for the consumer is lower in comparison with other alternatives
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leaf heal the planets future
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starting from the encouraging results of the leaf heal the planets future project in 2021 night edition we are now proposing a step forward to increase the awareness on the importance of research and innovation to improve trust in the researchers work by effectively involving the society in experimenting science through 600 events all activities will cover eu green deal topics farm to fork biodiversity circular economy zeropollution toxicfree environments health wellbeing energy and resource efficient buildings secure energy sustainable and smart mobility the main goal is to make science accessible and fun to everyone thus generating a practical understanding of how to cope with climate change issues the leaf project will be developed in 21 cities in italy involving 39 partners with a series of events happening during the last week of september 2022 and 2023 thus including the night leaf 2223 project will include a series of specific activities dedicated to schools to permit researchers to engage with teachers and pupils on challenges related to climate change sustainable development health and other issues related to the european commission priorities such as the european green deal in particular in this edition we will reinforce the experience at school through a dedicated work package on researchersschool involving institutes located in small towns with difficulties in reaching night events first year will be devoted to fulfill the achievements reached in last editions while in 2023 our main goal will be the improvement of project kpis thanks to the validation of the researchersschool activity the overall result will be a relevant increase in the awareness of why and how the researchers work is relevant for the benefit of our current and future planet as well as effectively encouraging young people in embarking in scientific careers by generating a real impact on science
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sst networking security data sharing horizon europe top5
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this horizon europe grant is to be understood within a wider context on eusst where other grants are being executed simultaneously with the common objective of improving the eu autonomy on space surveillance and trackingin particular this top focuses on support the upgrade development and security issues of eusst infrastructure based on the european network of assets sensors operation centres front desk the eusst infrastructure will remain under national control meaning mainly sensors and operation centres but increased coordination is needed due to the increased number of assets contributing to the european sst system sst networking of sensors operation centres eu sst network command control considering the increased number of objects to be handled an increased number of events and users is expected the european sst system has to evolve to a coordinated scheduling of the resources and assets ensuring that the events are covered in an optimum way while the current survey and tracking of the space objects population continues to be performed research on eusst network hardening against external threats the research concerns securitycritical aspects of the existing eu sst network next generation exchange protocols solutions for ssa enhancing interoperability and security robustness information assurance intrusion detectionthe starting point of these activities is the output of 23sst201820 which constitutes the state of the art on sst matters
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spatiotemporal linked data tools for the agrifood data space
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stelar will design develop evaluate and showcase an innovative knowledge lake management system klms to support and facilitate a holistic approach for fair findable accessible interoperable reusable and aiready highquality reliably labeled data the stelar klms will allow to semiautomatically turn a raw data lake into a knowledge lake this is achieved by 1 enhancing the data lake with a knowledge layer and 2 developing and integrating a set of data management tools and workflows the knowledge layer will comprise a a data catalog offering automatically enhanced metadata for the raw data assets in the lake and b a knowledge graph that semantically describes and interlinks these data assets using suitable domain ontologies and vocabularies the provided tools and workflows will offer novel functionalities for a data discovery and quality management b data linking and alignment and c data annotation and synthetic data generation the klms will combine both humanintheloop and automatic approaches to leverage background knowledge of domain experts while minimizing their involvement to reduce manual effort and time it will increase the automation of finding and selecting relevant data sources configuring and tuning the involved data management tools and designing executing and monitoring endtoend data processing workflows adapted to different user needs the klms will include specialized tools and functions for geospatial temporal and textual data an organization ranging from a dataintensive sme to the operator of a data marketplace will be able to use the stelar klms to increase the readiness of its data assets for use in ai applications and for being shared and exchanged within a common data space the stelar klms will be pilot tested in diverse realworld use cases in the agrifood data space one of the nine data spaces of strategic societal and economic importance identified in the european strategy for data
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new horizons in quantum transport from band structure geometry to emergent curved spacetime
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the theory of electrical thermoelectric and magnetoelectric transport lies at the core of condensed matter research because it allows to probe many ground state properties as well as dynamical and temperaturedependent features and harness them for advancing technology due to the progress in precision and resolution of experimental techniques formerly inaccessible nonlinear and nonlocal effects take an increasingly central role however this pace is not matched in theory where the physical understanding of response phenomena beyond the local and linear approximation remains fragmented the advent of new quantum materials makes it necessary to take our understanding of transport theory to the next levelhere i propose a universal and intuitive approach to quantum transport based on wavepacket deformations which allows the organization and prediction of complex transport phenomena with the help of geometric band structure properties the goal of this research program is to develop this concept into a powerful and applicable tool in order to accelerate our comprehension of novel transport phenomena and prediction of new ones to this end using diagrammatic methods i will generalize the concept of the anomalous quasiparticle motion to all orders in the response thereby significantly expanding on the concept of berry curvatures connecting wavepacket deformations with gravitational phenomena i will recast the theory of quantum transport in terms of a motion in curved spacetime i will apply these concepts to novel flatband platforms by employing an innovative mapping of the quasiparticle flow between real and momentum space such powerful technology will enable the creation and investigation of dynamical gravitational fields in a condensed matter setting the geometric formulation of quantum transport will reshape our understanding of condensed matter physics and lead to the discovery of new phenomena like gravitational anomalies in quantum materials
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language processing in blind early visual cortex understanding limits of functional plasticity in human brain
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what makes the cognitive functions to always fall in the same brain niches in people all around the world this consistency might be driven by shared experience characteristic of our species alternatively it might be driven by genetic blueprints predisposing certain brain areas to process specific types of informationto tackle this puzzle i want to understand the functional plasticity of the early visual cortex genetically predisposed to process vision in people born blind we know that in blind individuals this brain region responds to language while this discovery can be groundbreaking for our theories of brain plasticity its theoretical implications are debated particularly because we do not know what properties of linguistic stimuli are represented in the blind early visual cortexthe project objective is to fill this gap in knowledge and disentangle two hypotheses for language processing in the early visual cortex of blind individuals one hypothesis is that linguistic effects in this region are an extension of its typical visuospatial computations that implies that this region represents linguistic stimuli through concrete physical properties of language referents an alternative possibility is that responses to language in the blind early visual cortex are driven by the development of truly abstract representation in this region that implies that this region can represent more conceptual properties of language referents or even the linguistic properties of words and expressions themselves my project will use advanced neuroimaging approaches such as mind reading from fmri signals and inducing virtual lesions with tms to thoroughly test these two hypotheses by doing so it will evaluate two fundamentally different perspectives on functional plasticity in the human brain and will significantly improve our understanding of how sensory experience and genetic blueprints shape the implementation of cognitive functions in this organ
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life cycle center for power cable diagnosis
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the eu goals for the clean energy transition require at least a 55 reduction in greenhouse gas emissions from 1990 levels by 2030 according to the fit for 55 package to achieve these goals electricity grids will be required to operate in an overall context of 50 electricity production from res of any scale by 2030 the huge rise in the share of solar pv and wind in total generation fundamentally reshapes the european power system and significantly increases the need to build new hvac or hvdc cable connections these will have a crucial role to link islands or offshore wind parks to mainland or to connect countries over long distances the cablegnosis project aims to deliver innovative cable technologies that will support the clean energy transition era for the 2050 targets set at european level cablegnosis project will develop innovative insulation and conductor design technologies high performance and environmentally friendly cable insulation materials ageing studies of superconducting cables recyclability technologies for the materials used in power cables as well as prefault condition aging and remote monitoring aibased tools a feasibility assessment framework and detailed analysis for the use of superconducting cables for submarine connections a respective feasibility analysis will be developed for the offshore wind parks in the netherlands and germany the cablegnosis technologies will be validated in five european countries italy uk greece hungary cyprus cablegnosis will deliver a complete deployment plan for supporting the development and operation of efficient reliable and environmentally friendly cable systems to support the energy transition the deployment plan will provide the scalability and replicability framework of using the cablegnosis technologies in future cable development projects with emphasis in the ukmorocco interconnection cyprusisrael interconnection offshore developments in the aegean sea
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a natural breast for cancer survivors resorbable implant supporting tissue regeneration
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of the 3 million women undergoing breast cancer resection every year only a few opt for breast reconstruction due to pain concerns about followup procedures and the lack of options for lumpectomy patients traditional implants cannot be used with only 2030 of lumpectomies being reconstructed autologous tissue transfer requires multiple painful interventions to reconstruct large volumes and obtain satisfactory results furthermore both implants and autologous solutions require multiple followup surgeries increasing costs and pain for the patients regenera will be a unique solution for lumpectomy patients a resorbable implant designed to restore a natural breast through tissue selfregeneration it is a cellfree porous scaffold made of resorbable biocompatible polyurethaneesterether with a biomimetic architecture it is designed to avoid followup surgeries and eliminate the risks associated with silicone and saline implants rupture leakage alcl and fat grafting
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sensorbees are enhanced selforganizing biohybrids for ecological and environmental surveillance
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sensorbees aims at using honeybee colonies as a sensor network for tracking a set of important but undersampled ecological status variables 1 the level of pollination service in the surrounding region and 2 the level of diversity of blossoming plants the pollination of plants is not only significant for human society in agriculture but it is also the trophic basis of the food webs that support all the other trophic layers of animals that are currently endangered in the 6th mass extinction that we are currently facing we will equip a honeycomb that fits into a conventional beehive with a microrobotic system that can reach every single cell on the comb thus we will be able to inspect the content of each cell selectively and store its assessment into a database containing the history of each single comb cell over years the robot will photograph the brood in the cell at fullsize from a short distance allowing its size and health measurement sensorbees will perform specific manipulations on these comb cells for maximizing and ensuring pollination service to the environment to favor and support plant diversity and to defend itself against detrimental developments moreover we will equip the hive with a smart pollen trap capable of selective collection and visual analysis of the pollen brought into the hive by the bees the pollen influx along with the data collected by the robotic agents in the hive will provide information about the health of the colony as well as on the diversity of plants within the foraging area of the bees ie 510 km around the hive thus sample areas of 78314 sq km health estimates on the colony level can be made by looking for anomalies in brood growth and breeding success and by comparing the data streams from the hive entrance local weather data and brood dynamics data fusion will be applied to several colonies to eg locate potential problematic feeding sites
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the impact of internal waves on mesophotic coldwater coral mounds in the central mediterranean past present and hope for the future
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coldwatercoral cwc habitats are sensitive biodiversity hotspots under severe threat from human activities such as bottom trawling this is particularly true for the cwc mounds that are recently discovered in mesophotic depths 30150 m of maltese waters in the central mediterranean the origin of these cwc mounds is still unknown and due to the lack of scientific data these habitats are still not protected hopewaves aims to provide an indepth analysis of the mesophotic cwc mounds in se maltese waters which is essential for planning and enforcing new marine protected areas mpas networks hopewaves proposes an interdisciplinary approach geology oceanography and paleoecology to investigate the factors controlling the development of these structures in recent and past climates including the role of internal waves and tides iws the specific objectives of this project are 1 to assess the distribution pattern of recent mesophotic mounds and their associated communities 2 to determine the characteristics of water masses around the mesophotic mounds to define the possible depth of iws and 3 to develop a paleoenvironmental model for fossil mesophotic communities that were formed under a warmerthanpresent climate during the oligocene and the role of iws in their formation specific planned dissemination and communication activities are in line with public and policymakers engagement hopewaves will be carried out at the department of geosciences the university of malta which together with two secondments will ensure highlevel training on seafloor mapping oceanographic data analysis grant writing and project management the fellow will also transfer her knowledge in the field of carbonate sedimentology to the host by contributing to teaching and mentoring activities this project will increase the fellow chance of having a permanent position in eu universities marine and oceanic institutes and centres dealing with coral reef research
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highimpedance superconducting circuits enabling faulttolerant quantum computing by wideband microwave control
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a physical system implementing a quantum bit qubit is never perfectly isolated from an uncontrolled environment the system dynamics is thus noisy modifying randomly the qubit state this phenomenon of decoherence is the main roadblock to build a stable quantum computing platform in order to mitigate decoherence quantum error correction employs only a few code states within a much larger informational space so that noiseinduced dynamics can be detected and corrected before the encoded information gets corrupted unfortunately most known protocols require to control dauntingly complex systems with a degree of coherence currently out of reach our project is to build autonomously errorcorrected qubits encoded in highimpedance superconducting circuits in our protocol a qubit is encoded in the vast phasespace of the quantum oscillator implemented by each circuit in the form of gottesmankitaevpreskill gkp states the novelty is that the gkp states are fully stabilized by a modular dissipation induced by the coherent tunneling of charges through a stroboscopically biased josephson junction the coherence of the encoded qubit is expected to exceed that of existing superconducting qubits by orders of magnitude furthermore we propose to perform protected logical gates between encoded qubits by varying adiabatically the parameters of the modular dissipation paving the way toward faulttolerant quantum computing the major experimental challenge of our protocol resides in the exquisite level of control needed over a wide band in the microwave range we propose to address this challenge by developing novel onchip filters tunable couplers and isolators based on periodically modulated highimpedance transmission lines these onchip components would find a wide range of applications in quantum technologies and favor the advent of largescale quantum computing platforms
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digitizing women of medieval iberian historiography
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the interdisciplinary project digitizing women of medieval iberian historiography femiber aims to explore gender in the iberian middle ages in ways that embrace emerging technologies while fostering longlasting ties with the society and the cultural heritage in general the project aims to study female representations in the crnica de castilla castilelen and the portuguese livro de linhagens via methods of digital humanities the fellowship will take place at the department of humanities the universitat pompeu fabra barcelona under the supervision of prof mara morrs during the 24 months a digital prosopographical database of the represented women will be generated objective 1 and then the subsets of data will be visualized to explore patterns discontinuities and tendencies of the employed elements for sociopolitical and familial order in the two kingdoms through the lens of gender objective 2 when it comes to transsectoral training and mobility after completing an online specialization in curatorial practices a 6month placement will be carried out at the company digibs madrid the spanish heritagedigitization pioneer during the placement under the supervision by xavier agenjo trainings in patrimony digitization will take place in order to gain new skills and explore the projects potential in the digital cultural heritage field this experience together with the specialization in curatorial practices and the museum exposition form part of the objective 3 dedicated to promote and advance the projects links to the glamsector as well as facilitate public engagement and its use beyond the academia
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essential asymmetries of nature
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the symmetries identified in nature explicit or hidden are at the root of our knowledge in depth of its fundamental laws nevertheless observed asymmetries departures from that exact pattern are at the very heart of its beauty and of the explanation of how the visible universe came to be and what we are made of well known examples include the matterantimatter asymmetry of the universe and the violation of parity and charge conjugation observed in particle physics asymmetry focuses on the deep understanding of those asymmetries and also on revealing the new fundamental asymmetries yet to be discovered to explain major open questions and the particles on which they act in particular in the invisible sector made of neutrinos dark matter possibly axions and other elusive particles the team is strongly focused on this quest within a multidisciplinary approach mainly phenomenological studies although we bundle in leadership on key experiments such as superkamiokande gerda xenon and key laboratories such as fermilab desy and lbnl
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adaptable multipixel gas sensor platform for a wide range of appliance and consumer markets
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gas sensors are crucial in the personal and industrial monitoring to analyze personal exposure to air pollutants or to critical gases to control product quality such as in the food industry and in health care by analyzing gases from human body these applications require miniaturized low power and lowcost gas sensors with good gas selectivity to be integrated in personal devices in product packaging or in widely distributed sensor networksamusens aims at developing a gas sensor platform with flexible selectivity to different gas environments by combining a multipixel approach and artificial intelligence to adapt the data analysis to the targeted applications it is based on metal oxide sensing materials on microhotplate platform which are already available on the market for low power applications but suffer from a lack of selectivity gasselective multipixel sensors based on different metal oxide materials have been demonstrated but their industrialization is limited to few industrially available materials by using original additive manufacturing approaches for local liquidphase and gasphase depositions we aim at extending the choice of available materials and demonstrate their sustainability in waferscale processing artificial intelligence will be used both to accelerate the choice of materials and for data fusion to determine specific patterns in the gas analysis two specific applications targeting personal exposure and health care will demonstrate the adaptability of the platform based on an analysis of the users requirementsthe proposed architecture will be adaptable to many applications i from the flexibility in choosing the materials made possible by the local deposition techniques and ii from the programming protocol of the artificial intelligence this approach of products with ondemand properties will improve the resilience of the gas sensor industry by accelerating the time to market of products with enhanced performances
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a novel renewable energy storage system tailored for offshore applications
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by 2050 12 of world primary energy supply will come from wind of which 20 will come from offshore wind source dnvs energy transition outlook this poses a significant challenge to the electricity supply due to winds intermittent and unpredictable nature thus energy storage is a decisive factor in exploiting the full potential of offshore wind powerby providing a tailored technology for the offshore wind energy market we are addressing two of the biggest challenges in the energy industry 1 the temporal mismatch and 2 the spatial mismatch flasc hpes will enable the integration of largescale energy storage into offshore renewables catalysing the development of this nascent marketflasc addresses clientspecific pain points bridging the gap for offshore wind developers who are currently exposed to wind intermittency demand fluctuations grid congestion and market volatility a flasc energy storage system within the windfarm introduces flexibility to the energy supply increasing profitability which will enable a scaleup in new offshore windfarm deploymentsflasc hpes is a unique energy storage system tailored for offshore that combines two innovations 1 pneumatic precharging which avoids reliance on hydrostatic pressure 2using the ocean as a natural heat sink the system can be installed in shallow water 40400m and it is suitable for fixedbottom and floating applications flasc is unique when compared to other offshore energy storage concepts because it is compact and less expensive has a lower environmental impact and can be colocated in shallower waters within the footprint of the windfarmwith the repowereu plan the european commissions plan to make europe independent from russian fossil fuels aiming at 60gw of installed capacity of offshore wind energy by 2030 flasc will play a key role in meeting the energy targets while reducing dependence on fossil fuels and gas imports
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digital hate perpetrators audiences and disempowered targets
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the skyrocketing rise of digital hate can be considered the dark side of the democratizing power of the internet despite growing interest in the topic there has never been a systematic investigation about the perpetrators audiences and targets of digital hate to discover why digital hate emerges why it is often tolerated and what kind of effects it has digihate will analyze the reasons perceptions and consequences of digital hate for all involved actors in particular digihate will cause a paradigm shift by systematically looking at both disempowered and empowered targets of digital hate as well as their complex intersections nine work packages wps will form a unique multidisciplinary multilanguage mixedmethod approach including computational analysis qualitative work large comparative panel surveys experiments and a longitudinal measurement burst design in four countries wp 1 will conceptualize digital hate based on a contextrich netnographic analysis of online communities wps 23 will examine the actual perpetrators of digital hate using innovative methodologies wps 45 will study the perceptions and moderation strategies by the witnessing audience and explain why audiences remain silent wps 67 will comprehensively examine the effects on and the responses by the disempowered ie women and muslims and empowered targets ie politicians journalists and scientists as well as their intersections wps 89 will develop a novel multiplatform multiissue comparative computational analysis of digital hate that is built upon the actual perceptions of digital hate by those who receive it rather than using predefined potentially biased ai algorithms a project of this scale and disciplinary breadth has never been attempted before digihate will not only move significantly beyond the stateoftheart in the literature its findings will also be helpful for building and maintaining dignified societies in the digital world
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mechanistic systems modelling of plant environmental adaptation and cam photosynthesis engineering
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a major goal of evolutionary biology is to reconstruct evolutionary trajectories and outcomes from mechanistic descriptions of the interactions between organisms and their environment this goal is rarely reached due to the complexity of these interactions and their effects on fitness recent advances in computer technology that facilitate the solution and optimization of large mathematical systems have now brought such models into reach in mechsys i propose to develop a computational framework that builds on biochemical and physical principles to reconstruct how the interaction of the environment with plant anatomy water transport photosynthesis and metabolism shapes plant physiology and fitness mathematically the model comprises thermal balances as well as the balances of metabolites and water in different plant organs and in the compartments of leaf cells using net co2 fixation per root area over multiple days as a proxy for fitness for a given climate and soil the model will estimate fitness based on anatomical parameters and on systemslevel protein concentrations and enzyme regulation these estimates will allow us to rationalize the evolution andor predominance of different types of plants in specific habitats we will validate the model against proteomics and metabolomics data from representatives of c3 plants and the much more water use efficient cam plants covering desert plants as well as epiphytes moreover we will simulate evolutionary trajectories towards cam photosynthesis and succulence two traits whose evolution appears to be interlinked finally we will utilize the model to propose optimal strategies for engineering crops to become more droughtresistant in increasingly hotter and drier climates overall mechsys will establish test and apply a groundbreaking mechanistic systems modelling framework for evolutionary plant biology which will allow deep insights into the selective forces that shape plant physiology and evolution
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skill bill skill to boost innovation and professional fulfillment in a sustainable economy
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skillbills overall objective is to develop a large and strong foundation for the growth and acceleration of renewable energys deployment thanks to engaging with stakeholders of the whole chain diffusing scientific culture and skilling multilevel workersthe basic idea underling the project is that the knowledge should be diffused at several different levels and qualitatively appropriate both to train the adequate number of workers and to increase res awareness and to reach a more social and inclusive europethe project aims at creating several pathways to induce target groups to get interested or involved in res besides their initial level of education and their working position the technological res potential can be reached by increasing hard and soft skills of potential users and stakeholders developing interest in the topic and having clear and appropriate approaches such as tools and learning modules using suitable language its important beside the creation of instruments for the upskilling and reskilling of workers technician and designers to have awareness modules for unspecific public in order to fight against ignorance fake news gender gap and the phenomenon of functional illiteracy it is widely documented that lifelong suitable learning process is the fundamental driver to support the development maintenance and update of skills skillbill proposes concrete actions to accelerate the deployment of renewable energy at different levels1stakeholder community engagement 2knowledge sharing and peer learning3skilling upskilling reskillingskillbill will i analyse and involve all the interested parts in open discussion using adequate language ii create several different pathways to increase skills after having mapped knowledge gap and without gender prejudice iii develop and implement innovative learning method vi evaluate the work performed
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panideologies in central europe paradoxes of rightwing selforientalism
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the rise of rightwing populism in central europe coincides with the revival of panideologies cases of turanism promoted by the ruling party in hungary and panslavism popular among rightwing activists in slovakia pose a need to study these intellectual projects simultaneously in comparative and historical perspectives the common feature of these competing traditions is a contradictory combination of racism and selforientalism adepts of turanism and panslavism often define themselves as belonging to a noneuropean race and simultaneously sympathize with typical farright consensus on white supremacy why are panideologies rooted in outdated pseudoscientific theories so popular among rightwing populists of central europe today to answer this question we need to conduct a multidisciplinary study combining social anthropology and history the proposed project aims to understand how modern adaptations of panideologies differ from the original versions popular in the first half of the 20th century and how these transformations correlate with the aims and resources such as access to state institutions of the ideologues the novelty of the research project includes the suggestion to look at rightwing ideologies as phenomena embedded in the colonial and postcolonial history of the region i propose to study turanism and panslavism as products of contact zones coevolving and constantly influencing each other and affected by overlapping colonial regimes and postcolonial conditions following the guidelines of the horizon europe programme to support social cohesion and inclusiveness we need to conduct a focussed study of processes of polarization the research project aims to explain how panideologies attract new followers and why they are becoming popular again since the beginning of the last century
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boosting upstream and downstream processes to maximize yield of phb production and 23butanediol
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a circular biobased economy is a key element of a european low carbon economy and is projected to increasingly contribute to greenhouse gas ghg emissions reductions decreased dependence on fossil resources and drive economic growth over the next decades it can help meet the european green deals goals including its plan to reduce eu greenhouse gas emissions by at least 55 by 2030 compared to 1990 levels it also contributes to other eu initiatives including the circular economy action plan the biodiversity strategy zero pollution action plan and the farm to fork strategy eu biorefineries producing biobased products are expected to be an important part of the circular biobased economy moreover deployment of biorefineries that utilise eu biomass will increase safe supply of raw materials decrease emissions and create jobs and business opportunities especially in rural areas approximately 300 chemical and material driven biorefineries at commercial or demonstration scale are located in the eu promofer project will address the valorisation of two kinds of feedstock lignocellulosic biomass and food industry waste through the improvement of the fermentation processes and downstream purification it will be produced 3 ssbd circular biobased products 1 2 polyhydroxyalkanoates phas to be used in geotextile nets applications agriculture sector and coated paper packaging applications packaging sectors 3 23butanediol 23bdo to produce biobased pu for the technical textile applications in the fashion industry sector the integration of these waste streams as biorefinery feedstocks will allow reducing the volumes of landfilled waste improving competitiveness resource efficiency and opening new opportunities for the bioplastics production with added advantages of environmental performances and social acceptance
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public trust in contemporary europe trusting the antitrust protrust
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large firms such as amazon google and facebook have been making worldwide headlines for abusing their market power and violating antitrust rules within the european union eu the european commission ec has been a regulatory powerhouse in competition policy with the capacity to counterbalance unfair dominance of large firms such antitrust cases tend to gain news coverage and lead to discussions in the public sphere in other words they become subject to politicisation but does politicisation affect citizens trust in public authorities and large companies and if so how protrust public trust in contemporary europe trusting the antitrust investigates the effect of politicisation of eu antitrust cases on citizens trust in the european commission and in the firms involved it does so through an innovative combination of 1 a claimsmaking analysis of media coverage of antitrust cases in selected countries and 2 survey experiments based on the identified media frames from the claimsmaking analysis protrust is hosted by arena centre for european studies university of oslo where it benefits from the expertise of prof tobias bach and other academics in the areas of trust public administration and eu studies it also relies on the support of two secondment institutions govtrust centre of excellence university of antwerp and lund university adding key expertise in the areas of political economy transparency and technology protrust builds a bridge between politicisation and trust research advances knowledge on politicisation in the field of competition policy and provides a novel analysis of the impact of media frames in relation to competition and antitrust considering the dominance of large firms and the emerging challenges of democratic governance in the digital age analysing the link between politicisation and citizens trust is a timely and pressing topic
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therapeutic discovery for cholangiocellular carcinoma
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cholangiocarcinoma cca is one of the deadliest cancers comprising a heterogeneous cluster of malignancies that are distinct to hepatocellular carcinoma hcc and that can emerge at any point in the biliary tree while not very common cca is responsible for 2 of cancerrelated deaths worldwide annually and rising the incidence in european countries is increasing rapidly ranging from 1 to more than 4 cases100000 cca is mostly diagnosed very late resulting in aggressive disease progression poor treatment response and dismal prognosis with a median survival of less than 2 years curative hepatic resection is an option in 1030 cases and is mostly linked to recurrence within 12 months in over 50 of patients for most patients diagnosis will occur when the disease is already too advanced and the only options are chemotherapies or palliative care current standardofcare for cca is unsatisfactory with very limited efficacy and adverse effects recently approved secondline therapeutics slightly improve outcome but are only suited to a small subset of cca patients thus there is a major unmet medical need for novel therapeutic strategies to improve patient outcome based on a robust data package obtained in a panel of cca models within erc hepcir here we will explore the use of a novel class of compounds exploiting a unique and differentiated firstinclass mechanismofaction and validate their efficacy in vivo as a firstline therapeutic for cca proofofconcept studies will be performed in stateoftheart patientderived models combined with scrnaseq and proteomics the data obtained will serve as a preind data package for this indication an established collaboration with a pharma partner will ensure fasttrack completion of the preclinical development towards ind collectively erc poc candy will deliver completed proofofconcept for a novel therapeutic approach for cca which has the potential to transform patient care
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tff2 production and molecular mechanism studies to support new therapeutic approaches for gut diseases
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inflammatory bowel diseases ibd are chronic gastrointestinal gi conditions which affect approximately 13 and 2 million people in europe and north america respectively with a growing number of incidences in asia as well currently existing therapies only alleviate the symptoms and suppress the inflammation but dont promote gut repair the development of novel therapies is limited by a lack of understanding of the underlying processes of gut healing and repair although trefoil family factors tff are major players in gut epithelium restitution and repair very little is known about their molecular mechanisms and interaction partners in this project i will attempt to close this knowledge gap and will focus on trefoil family factor 2 tff2 the proposed project aims to identify tff2 interaction partners i study their structureactivity relationships ii and produce tff2based peptidomimetics iii i will use chemical synthesis coupled with structure elucidation to design and produce tff2 photoactivatable probes for the identification of tff2 interaction partners then structureactivity relationship studies of tff2 and identified partners will be carried out to define structural determinants of binding and activity based on this knowledge i will design novel tff2based peptidomimetics and study their stability binding to tff2 targets and effect on epithelial restitution the proposed project will deliver fundamental insights into molecular mechanisms of gut healing and yield a set of novel peptidomimetics which could serve as leads for further development of therapies for ibd and gi conditions
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ultrafast holographic ftir microscopy
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many human pathologies such as cancer are due to complex biochemical alterations that start at a subcellular level and lead to progressive changes that result in a heterogeneous tumor composition the polyclonality of tumor cells hampers the diagnosis and the therapy giving rise to tumor clones that lead to therapy resistance and promote metastases an accurate diagnosis of tumor biopsies to identify these particular cell clones is crucial to provide targeted therapy tailored to the tumor characteristics to improve the patient outcomes and increase survival rates for this vision to come true we introduce ultrafast holographic ftir microscopy trophy as a paradigm shift in vibrational microscopy blending elements of photothermal infrared ptir fourier transform ftir and digital holography microscopy dhm trophy brings these techniques to the unprecedented ultrafast timescale where the refractive index change induced by coherent ir vibrations is probed at its peak value before thermal relaxation trophy borrows from ptir the combination of ir vibrational excitation with visible probing for high spatial resolution from ftir the use of timedomain interferometry to obtain a high spectral resolution from broadband excitation from dhm highly sensitive and quantitative detection of the refractive index phase change combined with artificial intelligence algorithms this technology will enable quantitative concentration imaging of molecular biomarkers with high spatial resolution high chemical selectivity and high speed with a transformative impact on medical research and clinics in oncology it will be applied to intraoperative diagnosis of tumor biopsies providing tumor grading staging and subtyping and supporting complete tumor resection it will also allow to determine the best therapeutic approach tailored to the patient and identify resistant tumor clones under targeted therapy paving the way for precision medicine in cancer
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molecular mimicry and immune evasion in malaria parasites
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parasites have evolved elaborate strategies that maximise their fitness central to these strategies is their interaction with the host immune system for instance with immune receptors which mediate pathogen recognition or immune tolerance human malaria parasites encode a family of 200 rifins some of which are molecular mimics of human selfidentifying proteins and that bind toleranceinducing receptors however very few host targets of rifin proteins are known our data suggests that the family at large may form an elaborate repertoire of immunomodulatory effectors we postulate that rifins are deployed to manipulate host immunity in order to facilitate parasite persistence in its host we further hypothesise that this immune regulation is underpinned by a complex specificity code and a distinct bethedging expression program in the trojan project we will investigate and contextualise immunomodulation by malaria parasites in the arms race between the parasite and its host firstly given the sequence diversity of rifins we will optimise a method to measure gene expression without the need for a reference genome on a single cell level we will then deploy this tool to understand how expression of rifins is associated with malaria symptoms and persistence in longterm natural infections secondly we will decipher the range of immune targets of rifins as well as the rifinspecificity code and use lineage tracing to understand how diverse immunomodulatory expression patterns arise finally we will seek to understand how malariainfected individuals respond to immunomodulation by interfering with rifinreceptor interactions altogether we will reveal how pathogen molecular mimicry and manipulation is central to their success this study will transform our understanding of fundamental aspects of parasite biology as well as immune homeostasis and could provide new tools in the continuing fight against malaria
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demystifying mechanisms of metal impurities during co2 mineralization of industrial solid wastes
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anthropogenic climate warming has led to more frequent climate extremes and pollution episodes posing serious threats to the ecological environment and human health the rapid development of co2 mineralization technology for industrial solid wastes offers a promising solution to encapsulate co2 while stabilizing wastes however unlike desirable natural silicate minerals like olivine and wollastonite industrial solid wastes exhibit a complex and diverse composition the efficiency of mineralization in the carbonation process can be significantly impacted by the competitiveness of impurities relative to camg whereas the correlated systematic assessments of impurities competitiveness remain lacking in addition the leachability of potentially toxic elements after mineralization has not been explored raising significant safety concerns encapsulate takes an interdisciplinary approach combining the researchers experience in waste characterization and thermodynamic modeling with the supervisors expertise in interfacial geochemistry and molecular modeling to address these hitherto neglected challenges headon to this end encapsulate will establish publicly available datasets and novel models to i estimate the impurities constraints on mineralization efficiency at the outset ii propose possible strategies to reduce the environmental impacts of using carbonized products in practical applications and iii link co2 emission to specific activities in industries the outcomes will benefit eu organizations and industrial stakeholders engaged in co2 mitigation efforts the fellowship will be carried out at universit grenoble alpes isterre joint research unit and work with both academics psi esrf cnrs and empa and industry partners amiii the supervisors expertise and the organizations equipment ensure successful research progress and unsurpassed academicindustry intercommunication
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the diplomacy of small states in early modern southeastern europe
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this project aims at producing a synoptic analysis of the foreign policy of small states in early modern southeastern europe for centuries the rulers of the crimea moldavia and wallachia ragusa transylvania and cossack ukraine had to cope with their difficult geopolitical situation of being at the borderlands between christian europe and the ottoman empire the project will be the first attempt for writing a comparative history on the following questions 1 what kind of strategies these small states followed in order to overcome their vulnerability and survive on the frontier not only of empires but also of civilisations 2 what was the impact of being placed at cultural borderlands upon their diplomatic practices 3 how did they try to overcome the problem of having to communicate and present themselves in two radically different political languages ie of their powerful muslim and christian neighbours 4 how did the agents of diplomacy function in this peculiar geopolitical and cultural context how did it shape their status practices and the kind of social gains available to them
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c and nterminal epitope conjugate immune cell targeted vaccines
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cnectvax will validate the technical and commercial feasibility of a new cancer vaccine platform that uses nanobodies targeting dendritic cells to codeliver antigens in vivo as of 2019 cancer affects over 19 million people worldwide and results in almost 10 million death annually however the treatment of patients remains a challenge immunotherapy options including dendritic cell dc based vaccines have become available but the clinical efficacy of such treatment remains very modest and restricted to patient subsets to overcome the limitations in the current stateofart solutions and break barriers to achieve higher clinical efficacy dr martijn verdoes proposes a novel molecular vaccine strategy that effectively delivers target antigens to dcs in vivo in the patient to concomitantly induce robust synergistic cd4 and cd8 t cell responses the technical feasibility of cnectvax will be assessed both in vitro and in vivo using monocytederived human dendritic cells modc and a mouse model containing humanized dcs respectively in both systems the functionality of dcs and the consequent t cell activation and immune responses will be measured subsequently commercial feasibility will be determined by verifying ip position and strategy performing indepth market and competitor analyses and finally consolidating these into a business plan to establish the best path to commercialization successful commercialization of cnectvax could reduce the profound socioeconomic burden of cancer extend and improve the lives of patients provide the pharmaceutical industry with further collaborative opportunities and stimulate further scientific research based on this platform to treat other pathogenic diseases
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inflatable concept aeroshell for the recovery of a reusable launcher stage a flight demonstration initiative
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the icarus initiative targets to fulfil the following calls objectives1 contribution to the maturation up to trl56 of enabling new technologies and subsystems including common building blocks inthe field of reentry solutions for space transportation2 maturation up to subsystem and system level technology demonstration with respect to the technologies for recovery of spacetransport vehicles elements launcher stagesin that regard the project will address the innovative reentry solution based on inflatable heat shields ihs deemed applicable forrecovery of launch vehicles stagesin order to demonstrate applicability of this innovative solution for the purpose above the project will pursue the following endgoalsa complete the maturation on ground of the key technologies enabling the inflatable heat shields flexible tps and inflatablestructureb carry out a missionsystem design loop to realize and fly in relevant environment a meaningfulscale demonstrator of aninflatable heat shield through a flight on board a sounding rocket where the upper part of the rocket will be recovered thanks to theihs demonstratorc execute postflight analysis and rebuilding for technology performance evaluation system behaviour identification and modelsverificationcrosscorrelationthe project will lean not only on the achievements and knowhow obtained in the frame of the father projects efestoefesto2respectively funded by h2020 and horizon europe firstbatch but also on the partners heritage in the reentry and flightdemonstration field consolidated through pastrecent projectsthe current programmatic picture of the initiative is to lean on a full eu consortium to complete the project in a 4year plan to carry out 1 flight campaign in eu with exploitation of eu assets test range sounding rockets ground segment
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nutrient redistribution by mammals as a key mechanism for ecosystem restoration
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declining soil fertility represents one of humanitys major challenges in the 21st century in the past large vertebrate animals played a crucial role in transporting nutrients between ecosystems supporting a more fertile planet today however species extinctions diminished population abundances and constraints on animal movement have reduced animalmediated nutrient transport by 90 compared to the latepleistocene in contrast anthropogenic use of certain nutrients nitrogen n phosphorus p and potassium k vastly exceeds planetary boundaries consequently some areas of the world experience excessive nutrient pollution and others nutrient depletion agricultural abandonment trajectories provide opportunities for largescale ecosystem restoration including rewilding of large vertebrates however where humans have altered nutrient geographies redistribution by wild animals may have unintended consequences for nearby ecosystems including to plant productivity carrying capacity carbon storage and endemic competitive advantages consequently changes to either anthropogenic nutrient loading or to animal dynamics during ecosystem restoration projects can have farreaching implicationsrenourish will develop an agentbased modelling framework that quantifies the redistribution of multiple nutrients across landscapes by different guilds of large mammals crucially this model will include the direct and indirect influences of predators an essential but often overlooked aspect of nutrient redistribution in terrestrial landscapes the renourish framework will then be applied to two restoration case studies in i nutrientdeficient and ii nutrientpolluted environments this transformative approach will directly help conservation practitioners achieve goals of ecological integrity and contribution to climate stability results will be disseminated via published papers interactive workshops conference presentations and popular articles
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lithium niobate quantum systems
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quantum technologies are expected to have a transformative impact by exploiting fundamental quantum mechanical effects for technological applications such as quantum computation quantum simulation quantum communication and quantum sensing photons are the only reliable qubit for quantum information transmission making them an essential resource for quantum technologies however quantum photonics will only meet its expectation as a ground breaking technology when integrated in a scalable fashion the solution lies in quantum photonic integrated circuits where photons are used to encode and process quantum information onchip offering scalable quantum information processing units currently different integration platforms are investigated with a selection of building blocks available however no platform has shown a comprehensive toolbox combining all functionalities on a single chip in this project i will demonstrate that the thin film lithium niobate on insulator platform can simultaneously link all quantum photonics building blocks on a single platform resulting in fully integrated quantum photonic integrated circuits i will develop integrated lithium niobate quantum systems linqs showcasing the generation manipulation and analysis of photonic qubits this will result in the first compatible integration platform hosting semiconductor quantum emitters quantum memories based on rareearth ions cryogenic electronics and superconducting singlephoton detectors together with the outstanding properties of cmoscompatible lithium niobate on insulator lowloss circuits and fast modulators by developing all required building blocks and linking them to scalable systems i will provide the quantum technology community a single integration platform for all quantum photonics applications linqs will lay the foundation for europes forefront position in a future photonicsdriven quantum technology industry
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impact of maternal nutritional status and microbiota on child anthropometric and metabolic development
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both overnutrition and undernutrition shape the capacities of the body to process food double burden of malnutrition and are thus important determinants of metabolic syndrome a cluster of conditions including high blood sugar or excess body fat and dietrelated diseases such as type 2 diabetes or heart diseases the first 1000 years of life from conception to second birthday are considered a key period of life where the metabolic capacities are adjusted we hypothesize that during this period exposures such as the nutritional and metabolic status of the pregnant mother her gut and vaginal microbiota the childs gut microbiota and other clinical parameters linked to pregnancy delivery and early life have an impact on how the metabolism develops the objective of the proposed research is to study the contribution of prenatalearly life exposures on the anthropometric and metabolic development of the child and whether these effects could be mediated by epigenetic changes for this i will spend 24 months in the university of lausanne switzerland for the outgoing phase prof pascale vonaesch followed by a returning phase of 12 months in fisabio spain dr pilar francino this collaboration gives me the unique opportunity to work on samples and data from two birth cohorts of under normally and overnourished pregnant mothers and their offspring both in a low and a highincome country lao pdr and spain i will bring my expertise in epidemiology and clinical research as well as specific knowledge and skills in analysing vaginal microbiota data to the host and associated partner in return i will dig into new concepts and acquire advanced skills in genomics from bench work to bioinformatics community analysis epigenetics nutritionrelated diseases as well as transferable and complementary skills in order to enhance my careers perspectives this interdisciplinary research will generate new insights in both basic science and public health
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a continent disarmed gun culture gun control and the making of western europe ca 18701970
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this research project is a comparative and transnational historical investigation of the lawful possession and use of small firearms by lawabiding civilians in europe between ca 1870 and ca 1970 over the course of this centurylong period europe underwent a silent revolution which led it from being a continent where guns were in daily use to becoming a place where weapons in civilians hands became associated with violence and crime this led to the progressive establishment of gun control measures and to the cultural deglamorization and depoliticization of guns as a cornerstone of public order social peace and more generally the smooth running of political systems the overall goal of the project is to study the root causes of this shift and its impact on european historythe project provides a wideranging examination of the gun question it adopts an integrated methodological approach that encompasses legislative measures cultural representations and gunrelated practices within a broad comparative and transnational diachronic framework involving select countries in western europe france the united kingdom germany italy spain and swedenheuristically the project does not equate the possession and use of guns with political violence and warfare instead it focuses on lawful gun ownership and use this constitutes a privileged point of view and a fundamental benchmark to fully grasp the impact and cultural roots of political violence the project has the ambition to write the first political social and cultural history of the gun question in europe it will not only fill a major gap in the current literature but also newly address the relationship between processes of enlargement of states competences the control of violence and the rights of individuals which ultimately lies at the core of the making of modern and contemporary europe and the nature of european citizenship
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managing uncertainty in disaster risk reduction an ethnography of data practices in ghanas emergency preparedness and early intervention infrastructure
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the mundi msca project explores the uses of digital innovations for the predictive anticipation realtime analysis and early intervention in multiple and intersecting threats to human security in ghana specifically the project takes the focal areas of ghanas multisectoral emergency preparedness and response effort that is the spread of infectious disease climatechange related flooding and manmade disasters in the context of mining activities as case studies to explore data practices in the countrys national disaster risk reduction drr strategy central tools of drr including strategic and evidencebased risk assessment operational plans and risk communication are directly tied to the systematic and standardized production and analysis of data about populations and their environs this has raised concerns about data quality in contexts characterized by historically incomplete and fragmented population registers and statistical reporting systems the mundi project seeks to answer the research question how innovations in data practices anchor the acceleration of interventions in human security in spite of multiple and layered uncertainties about data sources models and predictions exploring this question in the context of ghana will advance our empirical understanding of the base processes and material foundations of building realtime datafication in emerging data systems develop new theoretical approaches to evidenceproduction under conditions of sustained uncertainty and add to our methodological toolkit new frames for the comparative analysis of digital population data infrastructuring for the purpose of impact forecasting early warning and rapid deployment of first responders
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feedback mechanisms approach to resolve regime shifts in ecological systems
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our planet is changing at a pace never experienced before ecosystems worldwide are impacted by multiple anthropogenic pressures and are experiencing abrupt changes sometimes leading to regime shifts marine ecosystems are prone to these dynamics and regime shifts are at the spotlight of research which seeks to reduce the uncertainties related to our incomplete understanding of these processes three main questions need to be answered to understand regime shifts when they happen ie detection why ie drivers and characteristics and how ie mechanisms present literature has focused mainly on detecting regime shifts neglecting feedbacks and how ecosystems function this ignorance has limited the causal understanding of these phenomena and has hindered the capacity to predict them a fundamental step under global changes feedres brings feedbacks mechanisms at the fore and aims at responding to all the three challenges to understand and project regime shifts to fulfil this feedres will develop a cuttingedge methodological framework combining methods from system dynamics theory and ecology feedres will follow three steps 1 map worldwide marine regime shifts through a systematic mapping feedres will assess the extent of regime shifts highlighting knowledge gaps when 2 empirically study the important structural elements and connections that characterize marine systems under regime shifts from populations to socioecological systems feedres will apply a twostep modelling approach to understand how the system change during regime shifts why 3 develop mechanistic models to understand how changes in feedback mechanisms mediate marine regime shifts how based on the knowledge developed feedres will identify common feedback types in marine systems and will project the likelihood of regime shifts feedres will revolutionise ecosystem science and will increase the understanding on how complex systems behave under cumulative stressors
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deep learning air quality forecasts for four days
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aqplus4 will develop the first scientifically sound operational air quality forecasting system based on innovative deep learning and it technology based on the successful development of ai air quality forecasting models in the intelliaq advanced grant we will explore the combination of several deep learning models into one coherent concept test the transferability to new air pollutant species and other world regions furthermore the grant shall cover the necessary technical developments to prepare the data processing and deep learning software for operational use and we shall setup a dialogue with two identified stakeholders uba germany and nier korea to discuss the data processing and forecasting requirements as well as the deployment and maintenance options the stakeholder exchange will also include training activities including extended training of a korean researcher timely and reliable air quality forecasts are important to issue health warnings and prepare mitigation measures intelliaq has demonstrated higher accuracy forecasts compared to conventional chemistry transport model results the aqplus4 system will therefore constitute an important breakthrough innovation that may later be adopted at several environmental monitoring agencies around the world
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tackling limitations of future relevant thermochemical reactions by exploiting the dynamic surface behaviour of complex mixed metal oxides
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for a sustainable future highly active selective andfor a sustainable future highly active selective and stable catalyst are of utmost importance for the chemical industry the conventional steadystate operation of catalytic reactors reaches its limit this project opens up new perspectives on the opportunities of tailored oxide surfaces we aim to develop a dynamic responsive catalysts drc that change their surface structure dependent on the oxidizing or reductive character of the reactant mixture combined with oscillation between reducing and oxidizing atmosphere in forced periodic operation fpo our concept opens unprecedented opportunities for surface engineering at low reduction degree the drcfpo concept allows activation and net stabilization of activeselective metastable sites that are thermodynamically not accessible under conventional steadystate operation furthermore at high reduction degrees the drcfpo concept enables reversible formation of highly dispersed active nanoparticles out of the mixed metal oxide host structure upon oxidative treatment the atoms of nanoparticles can reintegrate into the host structure at ultimate dispersion this is a unique way to overcome irreversible catalyst deactivation by nanoparticle sinteringwith our expertize on mixed metal oxides based like spinels and perovskites we will enable the drc functionality by compositional tailoring and resolve general trends to leverage the full potential of this approach we aim to explore all relevant effects in four future relevant demonstrator reactions at low and high temperatures as well as oxidizing and reductive environment by a combination of synthetic analytic reaction engineering and operando characterization methodologiesthe acquired basic knowledge and proven feasibility of the drcfpo concept opens a paradigmshift in the operation of catalysts it generates groundbreaking ways to create defined active surface sites and avoid catalyst deactivation
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disorder in ultrafast phase transitions
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disrupt which stands for disorder in ultrafast phase transitions represents a theoretical physics initiative with the primary aim of harnessing both static and timedependent disorder to gain full control over ultrafast phase transitions occurring in quantum materialsa key aspiration within the realm of nonequilibrium physics is to attain the ability to manipulate the properties of quantum materials over time offering numerous potential applications in highimpact technologies such as ultrafast electronics probabilistic computing and quantum computing however in experiments where a pumpprobe approach is employed disorder is often viewed as an unwelcome factor that threatens to undermine the vision of achieving complete control over the dynamics of quantum manybody systems through the use of light our objective is to challenge this conventional perspective and demonstrate that disorder serves two fundamental purposes firstly it enables us to place the system in nonthermal states that would be otherwise inaccessible under equilibrium conditions as seen in ultrafast inhomogeneous disordering secondly it allows us to theoretically devise robust mechanisms for preventing the thermalization of quantum systems with direct implications for quantum memory technology this dual objective lies at the core of our proposalto accomplish these objectives we plan to implement for the first time according to our knowledge an outofequilibrium extension of realspace dynamical mean field theory this will enable us to investigate both the absence of thermalization in correlated electron systems experiencing static quenched disorder manybody localization and the ultrafast inhomogeneous disordered transition in vanadium dioxide involving annealed timedependent disorder
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role of astrogliosis in the recurrence of brain tumors after microsurgical resection
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malignant primary and secondary brain tumors represent the deadliest types of human cancer glioblastoma is the most common and the most lethal primary brain tumor standard of care is based on maximal surgical safe resection followed by fractionated radiotherapy with concomitant and adjuvant systemic chemotherapy despite optimal treatment the recurrence rate is higher than 90 on the other hand brain metastases secondary brain tumors from distant organs remain a substantial contributor to overall cancer mortality being the main cause of death in up to 50 of affected patients research on the resistance to chemo and radiotherapy has been widely performed however studies on the impact of surgery on the cellular biological phenotype have been curiously neglected even if the standard of care requires that all patients receive surgical resection if possible the contribution of the neuroinflammation to cancer progression is extensively studied however its role after surgical injury remains to be elucidated therefore we aim to mechanistically decipher the role of reactive astrocytes key regulators of neuroinflammation on the postsurgery recurrence of primary and secondary brain tumors we will use intravital microscopy digital pathology genetic and pharmacological selective targeting of reactive astrocytes and ultimately we will evaluate novel therapeutic approaches to improve clinical benefit
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collective dynamics of sleep
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sleep is a biological imperative for all animals insufficient sleep can have detrimental effects on individuals health cognition social functioning and overall fitness even among gregarious species sleep has largely been studied in lone individuals in laboratory settings divorced from relevant socioecological context limiting our ability to understand how social environments shape and are shaped by the sleep patterns of their members my goal is to bring the study of sleep into the collective context understand how social processes structure the sleep patterns of individuals groups and populations and test how gregarious animals navigate the opportunities and constraints imposed by sleeping as part of a group to do this i will integrate cuttingedge technologies with traditional fieldobservation methods to measure and model the collective dynamics of sleep among wild baboons to continuously monitor movement position and sleep of baboons at the individual group and population levels i will use gps and accelerometry tracking of members of 30 troops of wild baboons this will be combined with 3d laser scanning of the physical sleep environment overnight thermal videography sleepdisruption field experiments focal sampling of social behaviors and advanced computational modeling to shed light on how differentiated and multifaceted social relationships shape individual and collective sleep decisions and how these decisions in turn shape the overall social dynamics of groups this groundbreaking project will be the first to measure the collective sleep behavior of animal groups in a socially and ecologically relevant context as such it has the potential to shed wholly new light on social and ecological tradeoffs that gregarious species like our own must balance to satisfy the biological imperative of sleep
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solutions for constructions and bulding materials based on the energy absorption
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energy efficiency in buildings is a critical aspect of addressing climate change and reducing greenhouse gas emissions to contribute to this endeavor our research project focuses on the development and optimization of phase change materials pcms derived from biomass as a sustainable solution for thermal energy storage in buildings pcms have shown promise in enhancing energy efficiency by storing and releasing thermal energy as they undergo phase transitions however challenges such as low thermal conductivity and leakage have limited their widespread application especially in construction materials our project seeks to address these challenges by exploring the use of natural biomass materials such as plant fibers wood particles endocarps and husks as containers for pcms these lignocellulosic materials possess unique properties including high deformation capacity and porosity which make them promising candidates for effectively containing and activating pcms by utilizing biomass as pcm containers we aim to improve the thermal performance of building materials reducing energy consumption and greenhouse gas emissions to achieve our objectives we will conduct a comprehensive research program that includes experimental testing numerical simulations and optimization techniques
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mechanical oocyte measurement as a predictive biomarker for assisted reproductive technologies
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infertility is a major societal problem and one in six people must use assisted reproductive technologies art to conceive however art success rates remain low ca 20 which represents a significant burden for the patients due to the heavy treatments and high risk of miscarriage recent studies have revealed that the mechanical properties of female gametes oocytes are tightly regulated and can change with advancing maternal age ama leading to a higher risk of miscarriage or congenital diseases mechanical biomarkers have thus been proposed to score highquality oocytes in art however their use is hampered by 1 the lack of precise knowledge of mechanical phenotypes associated with ama and oocyte quality and 2 the absence of appropriate technology to measure oocyte mechanical properties in medical settings in momart i propose to develop a userfriendly and noninvasive approach for the mechanical phenotyping of oocytes based on an innovative miniaturized measurement system with computational analysis i will characterize mechanical phenotypes associated with ama andor developmental defects in mouse models to establish the predictive value of mechanical biomarkers for oocyte quality i will finally evaluate the proposed microfluidic approach in a reproductive medicine department in the frame of a nonacademic placement and aim thereby to identify minimal requirements that my approach and device must meet to be applied for oocyte mechanical scoring in medical setting this comprehensive and interdisciplinary project will bring significant technological fundamental and medical advances in oocyte mechanobiology directly applicable to oocyte quality assessment and personalized diagnostics in art in momart i will interact with experts in microfluidics developmental biology and human reproduction upon completion of the fellowship i will have consolidated my interdisciplinary and intersectional profile which is key for my future career
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the acquisition of new meanings through novel word learning
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we learn new words almost on a daily basis as adults a new element is introduced in our vocabulary every other day with new words we also learn about new objects and ideas in most cases new words are not simply additional labels to be applied to familiar objects they connote meanings that are unknown to the speaker of a language however when we experience as adults an unfamiliar word typically its referent is not immediately available in the same context how then can language by itself constitute such a reliable instrument for the acquisition of novel meanings what do we exploit to induce new meanings on the basis of an unfamiliar sequence of sounds or graphical elements bravenewword addresses these questions in an innovative multidisciplinary perspective combining cuttingedge proposals from computational linguistics and empirical investigation techniques from experimental psychology and cognitive neuroscience bravenewword posits three main sources for lexicallydriven meaning acquisition linguistic context word structure formmeaning mapping the project advances a computational framework that models these mechanisms through datadriven psychologically plausible distributional systems trained on examples of natural language usage the quantitative characterizations and algorithmic definitions offered by these models constitute in turn the basis for bravenewword largescale empirical investigation involving both behavioral reaction times mousetracking trajectories diachronic language changes and neuroscience data eventrelated potentials neuroimaging with its innovative perspective and advanced computational and empirical approach bravenewword will constitute a nonincremental contribution to understanding how human speakers use new lexical information as a mean for enriching their semantic system and provide a groundbreaking perspective on the cognitive processes relating language and thought
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multilingual and crosscultural interactions for contextaware and biascontrolled dialogue systems for safetycritical applications
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eloquence is focused on the research and development of innovative technologies for collaborative voicechat bots voice assistantpowered dialogue engines have previously been deployed in a number of commercial and governmental technological pipelines with a diverse level of complexity in our concept such a complexity can be understood as a problem of analysing unstructured dialogues eloquences key objective is to better comprehend those unstructured dialogues and translate them into explainable safe knowledgegrounded trustworthy and biascontrolled language models we envision to develop a technology capable of learning by its own by adapting from a very datalimited corpora to efficiently support most of the eu languages from a sustainable computational framework to efficient and greenpower architectures and in essence that may serve as a guidance for all european citizens whilst being respectful and showing the best of our european values specifically supporting safetycritical applications by involving humansintheloop overall eloquences project considers building on top and to improve of prior achievements in the domain of conversational agents eg recently launched and publicdomain large language models llms such as chatgpt eg more recent versions or lamda most of them developed in noneu countries while including key industrial enterprises from europe ie omilia telefonica synelixis eloquence will validate the developed technology through i safetycritical scenarios with humanintheloop for securitycritical applications ie emergency services in call centres and ii smart home assistants via information retrieval and factchecking against an online knowledge base for lesser risky autonomous systems ie homeassistants eloquence will target the rd of these novel conversational ai technologies in multilingual and multimodal environments and demonstrated in several pilots
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bayesian tools for onedimensional and threedimensional hadron structure
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parton distribution functions pdfs and transversemomentumdependent pdfs tmds encode our knowledge of the nucleon internal structure in terms of their elementary constituents quarks and gluons they are determined by means of global analyses of experimental data which require the development of suitable fitting methodologies pdfs and tmds represent an important input for precision studies at current and future accelerator facilities the development of reliable fitting methodologies and their subsequent validation in order to ensure the soundness of the corresponding results is therefore a crucial problem in highenergy physicsthanks to the wealth of new data and fitting methodologies the accuracy to which pdfs and tmds are known is rapidly improving with the reduction of the uncertainties an increasing tension has been observed among results from different groups making the discussion around the determination of faithful uncertainties all the more urgentthis research proposal bayesian tools for onedimensional and threedimensional hadron structure bayhadron develops a new methodology based on bayesian inference and a set of statistical validation tools for pdf and tmd determination the main goals of bayhadron are two 1 the development of a fully bayesian methodology for pdf determination providing a valid alternative to the methodologies based on parametric regression currently used within the community and the release of a first pdf set based on it 2 the application of validation tools developed within the pdf community to validate the fitting methodologies currently used for tmd determinations and their possible improvement by means of a bayesian approach both goals of bayhadron concur to a faithful determination of pdf and tmd errors introducing a set of innovative statistical tools in the field and making the proposal particularly timely in light of current and future experimental and phenomenological efforts
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tumor regulation assisted by immunity and nanotechnology
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cancer is the number one cause of death among europeans under 65 being estimated that half of europeans will develop cancer at some time in their lives despite the significant progress made in the prevention and treatment of cancer in recent years this disease continues to claim lives and straining the european health and social systems and economies in addition cancer incidence and mortality are predicted to raise as consequence of the covid19 pandemic to reduce these dramatic repercussions innovative therapies more effective and accessible to a wider population are needed to treat patients with advanced cancerthe overarching aim of the train project is to leverage the enzyme activities in the tumor microenvironment to boost the efficacy of cancer immunotherapies via molecularly engineered peptide nanomaterials capable of metabolic modulation of tumors and release of chemotherapeutic drugs train is focused on pancreatic adenocarcinoma paad and will develop biomimetic 3d paad models to test the proposed combined chemo and immunotherapy the feasibility of this major goal will be achieved through a multidisciplinary approach that will employ concepts from peptide nanotechnology enzymology immunology and cancer biology together with cuttingedge materials science proteomics and cell biology methodstrain is in line with the europes beating cancer plan aimed at reducing the negative impact of cancer for patients their families and healthcare systems and addressing cancerassociated disparities across countries while providing training and career development opportunities for a young and creative researcher at the intersection of peptide nanotechnology and cancer immunology
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building european nuclear competence through continuous advanced and structured education and training actions
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nuclear power and nonpower technologies are technically very complex facilities that operate in the increasingly challenging regulatory framework and market conditions development construction operation decommissioning waste management and oversight of these facilities require personnel with excellent education skills and motivation nuclear specialists that are equipped to work in multidisciplinary multicultural and competitive environments enen stands for the largest and most integrative nuclear education and training et efforts up to date attraction of excellent new talents followed by outstanding development through e crosscultural and crossdisciplinary activities are the overarching objectives excellent workforce should remain the basic enabler of safe longterm operation of existing and development of advanced facilities a detailed insight into the eu supply and demand of nuclear human resources for power and nonpower applications will be developed this will include industries academia technical safety organizations and regulators higher number of nuclear talents will be achieved through dedicated career related events and competitions for high school pupils and teachers students bsc msc phd postdocs and lifelong learners a strong mobility program will support over 100 personyears of nuclear career enhancing experience to about 1000 learners with over 25 million eur crossborder and crossdisciplinary mobility within and beyond eu will be promoted in cooperation with jrc oecdnea and partners from usa china korea and japan a single hub will be established to provide information on available educational training and job opportunities appropriate connections with the complementary nrt12 project facilitating access to research infrastructures will be maintained a centralized platform with coherent information on vocational training programs developed during the project will be established
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modern approaches to the monitoring of biodiversity
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eu policies such as the eu biodiversity strategy 2030 and the birds and habitats directives demand unbiased integrated and regularly updated biodiversity and ecosystem service data however efforts to monitor wildlife and other species groups are spatially and temporally fragmented taxonomically biased and lack integration in europe to bridge this gap the mambo project will develop test and implement enabling tools for monitoring conservation status and ecological requirements of species and habitats for which knowledge gaps still exist mambo brings together the technical expertise of computer science remote sensing social science expertise on humantechnology interactions environmental economy and citizen science with the biological expertise on species ecology and conservation biology mambo is built around stakeholder engagement and knowledge exchange wp1 and the integration of new technology with existing research infrastructures wp2 mambo will develop test and demonstrate new tools for monitoring species wp3 and habitats wp4 in a codesign process to create novel standards for species and habitat monitoring across the eu and beyond mambo will work with stakeholders to identify user and policy needs for biodiversity monitoring and investigate the requirements for setting up a virtual lab to automate workflow deployment and efficient computing of the vast data streams from on the ground sensors and remote sensing required to improve monitoring activities across europe wp4 together with stakeholders mambo will assess these new tools at demonstration sites distributed across europe wp5 to identify bottlenecks analyze the costeffectiveness of different tools integrate data streams and upscale results wp6 this will feed into the codesign of future improved and more costeffective monitoring schemes for species and habitats using novel technologies wp7 and thus lead to a better management of protected sites and species
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preparation of a joint action plan to support the emergence and growth of silver economy european ecosystems and strengthening their efficiency capacity interconnectivity and inclusivity
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senior econect project will prepare a joint action plan to support the emergence and the development of european ecosystems dedicated to silver economy as well as ensuring the inclusivity and interconnectivity between all the key innovation stakeholders of the sector and crosssectors the specific objectives of senior econect are the followingso1 support the emergence growth efficiency and interconnection of at least 4 european ecosystems dedicated to silver economyo2 unlock the full potential of silver economy sector by integrating key transversal areas targeting the ageing population beyond the scope of health and careo3 ensure inclusiveness and interconnectivity between the key innovation players from across the quadruple helix around the sector of silver economy at the local regional national and european level and beyondo4 increase the efficiency and innovation potential of silver economy innovators and projects by addressing key challenges and exploiting the opportunities offered by silver economyo5 encouraging synergies and complementarities between senior econect joint action plan and the innovation programmes of public authoritiessix partners representing innovation ecosystems and sectoral networks will join forces and strategies toward the strenghthening of european innovation ecosystem in silver economy eurasant in france munster technological university in ireland slovenian innovation hub in slovenia cluster saude de galicia in spain the european platform for sports and innovation and the european network for accessible tourism their effort will be supported by the engagement of 32 associated partners representing key innovation ecosystems members of the quadruple helix industry academia public authorities and civil society across europe
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a holistic approach of electric motor cooling
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electric motors emotors consume more than 40 of electricity produced globally the eu aims to save 40mt of co2 emissions per year until 2030 by deploying more efficiency emotors emotors are also the driving force behind evs currently leading the global efforts for decarbonisation of the transportation sector their efficiency is crucial in extending ev mileage unfortunately electrification plans for heavyduty earthmoving machines and aircrafts accounting currently 60 of fossil fuel consumption in transportation have to overcome among other limitations the technological barrier of excess heat generated in the emotor copper windings during powerdemanding operations associated with these sectors ecool promises to address this challenge via the development of a holistic emotor cooling technology maximising heat transfer through directcontact spray cooling ecool aims to achieve this technological breakthrough at timescales compatible to those required for industrial innovation to reach the market by integrating two interdisciplinary activities a development and manufacturing of novel oilbased dilute polymer mixtures of nonnewtonian nature which when employed in spraycooling thermal management systems will be a gamechanger b implementation of a universal design methodology for spray cooling optimised with the aid of new machine learning ml algorithms training datasets for the ml tool will be obtained by groundtruth experimental and numerical investigations also to be conducted for the first time in ecool the envisioned cooling system aims to provide unprecedented cooling rates at local temperature hot spots which can contribute to an average 20 increase in emotors efficiency compared to todays stateoftheart this will allow nextgeneration emotor utilisation over the whole range of transportation sectors thus facilitating significant additional energy and co2 savings relative to the existing eu plans
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first regenerative solidstate barocaloric refrigerator
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greenhouse gas emissions for refrigeration systems worldwide were in 2019 equivalent to the whole eu emissions longterm sustainability requires improvements in energy efficiency with a huge return on investment obtained from even slight improvements the mechanocaloric effect which refers to adiabatic temperature changes induced by stress or pressure is one of the most promising energysaving new technology for cooling systems mechanocaloric research produced in only 14 years highly performing materials overcoming electrocaloric and magnetocaloric materials furthermore mechanocaloric materials use noncritical cheap abundant and nontoxic elements recent papers evidenced colossal barocaloric effects around the spin crossover sco temperatures for some molecular complexes the frostbit project overall objective is to develop the first operative refrigerator based on a radically new solidstate technology by using barocaloric materials in a regenerative cooling device in more specific objectives the project aims to 1 design sustainable syntheses of compounds for barocaloric applications exploring synthetic pathways to optimize costs and low environmental impactlow carbon footprint vs barocaloric performances 2 shape sco materials in order to obtain densified objects with centimetric sizes study extensively their thermal mechanical and barocaloric behaviour and explore the optimization of those properties through the preparation of composites ceramics 3 model design and build the constituting elements of a barocaloric refrigerator barocaloric regenerator thermal and pressure fluid circuits while the technology could potentially address a wide range of temperature as an initial step we propose to specifically design and build a refrigerator yielding 100 w of cooling power at room temperatures and providing a temperature span of at least 20 k with a target cop between 4 and 6 corresponding to 30 of carnot efficiency
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bioeconomy excellence alliance for stimulating innovative and inclusive green transition
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beaming aims to raise excellence by enhancing innovation and knowledge valorisation within the bioeconomy domain through cooperation between higher education institutions with a particular focus on widening countries in centraleastern cee and southeastern european see eu member states and the western balkans improved global competitiveness and visibility of higher education institutions hei will be achieved through establishing effective technology and knowhow transfer between widening countries and eu14 member states with more developed bioeconomies and ri ecosystems exploring and adopting structural reforms educational priorities and a culture of excellence the beaming alliance works towards 7 specific objectives 1 build the capacity of earlycareer researchers in all aspects of bioeconomy research 2 facilitate the reform of institutional practices and policy frameworks towards excellence 3 foster networking knowledge exchange and crossdisciplinary collaboration by establishing sustainable communities of practice 4 design joint research and innovation strategies and launch joint research projects 5 design a complex portfolio of activities for adopting open science practices 6 strengthen the valorisation of research results by increasing tech transfer capacity 7 support the participating institutions to move towards inclusive institutional culture including gender equality we aim to foster the uptake of the quadruple helix innovation ecosystem approach to provide a framework for higher education institutions to work collaboratively with industry government and civil society thereby we aim to enhance their innovation capacity and the applicability of research results local and regional implementation strategies and roadmaps will be developed regarding the relevant era policy agenda actions in the higher education sector particularly in the domains of bioeconomy and circular economy
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social inequalities in the risk and aftermath of miscarriage
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one in four women experience a miscarriage loss of pregnancy may affect fertility intentions and lead to adverse mental and physical health yet we know little about how social inequalities affect the risk of miscarriage how miscarriages may exacerbate existing social inequalities in population health or how context shapes these experiences one reason for this is poor quality of data as miscarriages are often either underreported in surveys or only included in health registers if they require hospital care moreover to date sexual and reproductive health has often been ignored in life course epidemiologythis proposal goes beyond the stateoftheart by being the first comprehensive study of the patterns of social inequality in miscarriage and its outcomes it reaches this goal by assessing the patterns of miscarriage underreporting in surveys before obtaining its estimates it will make groundbreaking contributions by1 analysing underreporting patterns of miscarriage and using this in further analyses to obtain more reliable results than before2 showing how individual and familylevel social inequalities affect miscarriage risk over the life course3 establishing how mental and physical health consequences of miscarriage depend on ones social background and may widen social inequalities in health4 uncovering the role of national and subnational context in social inequalities in miscarriageunlike many previous studies based on small and outdated samples i use longitudinal population registers and large representative surveys in finland france and the uk that are exceptionally rich in miscarriage socioeconomic other reproductive and health data and can be triangulated to obtain more reliable resultsthe project will lead to a significantly better understanding of a common reproductive experience affecting mental and physical wellbeing and can help policy makers improve reproductive and population health
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smart management of energy and costs in museums a chemical background for a control methodology for temperature and relative humidity fluctuationss
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fellow paola lucero host institution palack university olomouc upolcz supervisor karel lemr department of analytical chemistry dacupol cosupervisor petr bednar dac upol host institution and supervisor secondment cafoscari university cfu it isadora antoniano host institution and supervisor nonacademic placement gallerie dellaccademia in venice gav it silvia salvini aim of the project ro1 to give to the methodology that i published in 2020 for monitoring and control of fluctuations of temperature and relative humidity in museum environment a chemical background considering materials degradation ro2 to gain knowledge into materials degradation and determine what fluctuations can be tolerated by museum objects without damage ro3 to gain knowledge on historical buildings behavior and their capacity dumping outdoor weather variations ro4 to transfer the gained knowledge by training an initial set of endusers in cultural institutions to help them managing their energy consumption innovation creation of a methodology for characterization of museum indoor environment that considers material degradation enable conservation professionals to estimate how safe is museum environment in historical buildings under climate change influence to contribute saving energy by allowing wider yet safe fluctuations of temperature and relative humidity in museums with mechanical air conditioning systems procedure and data gain knowledge on materials behavior using analytical techniques to characterize degradation in mockup samples naturally and artificially aged and combine this data with the characterization of indoor environment in museums results 2 journal articles 4 conference presentations 7 workshops 5 public events an online professional forum online data repository for temperature and relative humidity museum records partner institutions gav esk krumlov castle viking museum hist museum of oslo nat heritage institute cz
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head to tail imaging of fluorescent carbon nanotubes for the characterization of the brain extracellular space
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the nanoheadtail proposes a novel and original approach combining fluorescence microscopy and nanotechnology to resolve the morphological and rheological properties of the brain extracellular space ecs at the nanoscale current methods allow to determine the local dimensions and fluidity of the ecs but they do not allow to resolve its structural complexity and are limited to an analysis in 2d this project proposes the simultaneous monitoring of the position the translational and rotational diffusion of fluorescent probes over time and in 3d allowing to determine the volumetric structure fluidity and inner organization of the ecs locally for that a novel type of asymmetric probes will be designed based on the localized functionalization of singlewalled carbon nanotubes with fluorescent color centers at their ends analyzed using a custom cuttingedge fluorescence microscope and tested in live brain tissues from mice models of the parkinsons disease the applicant will bring his strong expertise in the photophysics and chemistry of carbon nanotubes critical for the preparation of the probes in parallel the fellow will gain a highlevel handson training on optics assembly super resolution microscopy and single particle tracking imaging analysis and neurosciences the project will be performed at the iogslp2n cnrsuniv bordeaux a leading french research institution under the supervision of dr laurent cognet expert in the single particle tracking of nanoobjects the proposal contains wellidentified work packages which will ensure efficient science development but also project management career development training technology transfer and communication the fellows expertise the hosting lab the infrastructure facilities and the mentoring will guarantee the successful execution of the nanoheadtail goals and will allow the applicant to reach a high level of professional maturity and to develop his career as an independent researcher
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malaria diagnosis and prognosis with an electrokineticdriven aptamerbased lateral flow assay
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malaria remains a public health concern with 247 million cases and 619000 deaths reported globally in 2021 despite the increasing prevention and control measures driven by the world health organization who nearly half of the population is still at risk of malaria with a reported increase in the incidence of imported malaria in european countries to this end implementing largescale highcoverage early diagnosis and accurate prognosis of severe malaria is critical to reducing the impact of malaria in europe due to its high sensitivity parasite counting by microscopy observation is the current gold standard method however it is inappropriate for its application at the point of care poc the rapid diagnostic tests rdts based on lateral flow assay are the best option for poc testing since they accomplish the reassured criteria who recommends however this method doesnt provide quantitative prognostic information and has proved low clinical sensitivity with low parasitemia samples asymptomatic parasite carriers with this aim i propose for the first time the development of a smartphonepowered electrophoreticdriven aptamer paperbased lfa capable of providing a quantitative measurement of 2 parasite pfhrp2 panpldh and 2 host ang2 and crp malaria biomarkers within minutes compared to capillaritydriven lfa the flow control by electrophoresis enables the application of different synergic strategies to increase assay sensitivity such as integrated incubation steps and purification of interfering biomolecules highly specific aptamers will be developed by a fast and costeffective microfluidic selection approach used as bioreceptors with stability for electrokinetics this will enable an early diagnosis and an accurate prognosis of malaria reducing the risk of developing severe symptoms upon successfully validating the device in nonendemic areas host institution i expect its use in lowresource malariaendemic areas
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next generation circular biobased flagship packaging a catalyst for the green transition
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the terrific project will demonstrate at trl 8 biobased circular flagship solutions for improved properties packaging applications fulfilling the superior requirements in terms of performance along their entire supply value chain while improving circularity and resource efficiency to do so 6 ambitious specific objectives have been selected implement a firstofits kind multipurpose biorefinery for the obtaining of biobased building blocks including 14biobdo and c18dca at trl 8 and demonstrate its replicability successfully produce of biopolyesters and biomaterials with rrm 95 and improved properties barrier and durability at trl 8 including 14biobdo c18dca from the multipurpose biorefinery develop biobased recyclable compostable and highperforming flagship packaging products by means of traditional industrial technologies demonstrate the sustainability circularity and safety of the biobased materials developed for the flagship packaging products with respect to existing fossil or biobased benchmarks improve circularity and resource efficiency through the validation of multiple endoflife scenarios for the developed flagship products evaluate and demonstrate the replicability of the terrific concept through a multiactor approach to create an interactive innovation model for engagement of all the actors in the value chain in the exploitation of new business opportunitiesterrific is a multidisciplinary project engaging 19 partners from 9 countries covering the whole value chain including 6 smesan implementation plan is presented in the form of 7 work packages 5 of which are technical in nature synergy in communication and dissemination by the several partners and stakeholders including a multiactor interest group will maximize the project progress and impact solutions to overcome the barriers as well as appropriate deliverables tasks milestones and risks to complete the project objectives in due time are presented
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ignite the immersive media sector by enabling new narrative visions
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the future of media experiences is still to be written and the maturity of extended reality xr and artificial intelligence ai technologies provides a unique window of opportunity for the european creative and cultural sector ccs to reimagine digital cocreation interaction and engagement possibilities transmixr a consortium of eight representatives from the ccs and twelve leading industrial and academic partners combines the necessary interdisciplinary skillsets and domain expertise to create a range of humancentric tools for remote content production and consumption via social virtual reality the projects transmixr platform will provide i a distributed xr creation environment that supports remote collaboration practices and ii xr media experience environment for the delivery and consumption of highly evocative and highlysocial immersive media experiences the groundbreaking ai techniques for the understanding and processing of complex media content will enable the reuse of heterogeneous assets across immersive content delivery platformsusing the living labs methodology transmixr will develop and evaluate four pilots that bring the vision of future media experiences to life in four ccs domains i news media broadcasting ii performing arts and iii cultural heritage additionally the project will harness the creativity of the ccs and will forge interdisciplinary collaborations to demonstrate how immersive social experiences could be transferred to new application areas beyond the ccs the results of the project will contribute to the media and audiovisual action plan from the european commission in particular boosting the adoption of xr technologies opening new business models opportunities in new application areas and markets and gaining worldwide leadership in xr technologies while being deeply grounded in european values such as veracity diversity connectedness and universality
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beyond bad apples towards a behavioral and evidencebased approach to promote research ethics and research integrity in europe
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ethics and integrity are key dimensions of excellence in research and crucial for public trust in science beyond will reinforce efforts to promote adherence to the highest standards of research ethics and integrity reri and prevent research misconduct rm by developing and disseminating regulatory and educational interventions that elucidate institutional and individual responsibilities for ensuring and fostering research environments conducive to ethical research to that end beyond will adopt a complex ecosystemic perspective on research ethics and integrity that recognizes the multiple responsibilities of researchers and other stakeholders to enrich the overly simplistic bad apples approach that underpins most existing measures to prevent research misconduct beyond will explore the existing literature on behavioural ethics and moral psychology as well as the socioeconomic consequences of research misconduct and engage all involved stakeholders in a public consultation to guide and equip all stakeholders in the research ecosystem beyond will utilize this knowledge to develop 1 psychologically informed contextual interventions to promote reri and prevent rm from the perspective of individual and institutional responsibilities 2 methodologies to measure the short medium and longterm impact of reri trainings on attitudes and behaviours of students and researchers 3 a best practice manual and guidelines to supplement standard operating procedures from a complex research ecosystemic perspective as well as a 2030 roadmap towards improving the reri culture and 4 new training materials and tools to supplement existing educational efforts beyond will mobilize all stakeholders via the three thematic networks involved in the consortium enrio eurec the guild and the stakeholder advisory board to ensure widespread dissemination of results and facilitate their institutional uptake and embedding
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spatially and environmentally actuable nancomposite hydrogels towards nervous system repair
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this proposal aims to capitalize on my unique multidisciplinary expertise in nanotechnology tissue engineering polymerinorganic hybrids and microsurgical techniques while acquiring new proficiencies in the creation of breakable hybrid organosilica nanocapsules mesoporous silica nanoparticles and nanocomposite hydrogels i am driven to tackle the unmet needs opportunities and challenges in the fields of nanocomposite hydrogel design and nervous system repair by combing my current expertise with these new proficiencies to innovate nanocomposite hydrogels that are environmentally and spatially actuable specifically the goal of my proposal is to pioneer spatially distinct and environmentally responsive actuation of nanocomposite hydrogels in response to matrix metalloproteinase9 mmp9 peptide cleavage focusing on applications in peripheral nerve repair in order to achieve this ambitious objective i will develop mmp9 degradable polyethylene glycol pegmesoporous silica nanoparticle composites and mmp9 breakable organosilica nanocapsules through the incorporation of mmp9 cleavable peptides into silica nanoparticle structures mmp9 can therefore be used to induce 1 hydrogel degradation 2 release of encapsulated therapeutics and 3 capture of molecules by cleaved nanoparticle scavengers this proposal details a highly interdisciplinary approach to create a plugandplay nanocomposite hydrogel system to overcome obstacles needed to improve regeneration outcomes by combining neuroscience and microsurgical nerve repair with chemistry drug delivery biomaterials science and tissue engineering finally nanocomposite nerve guidance conduits will be tested in a peripheral nerve injury model to demonstrate in vivo mmp9 actuation of these hydrogels
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fostering nitrogen deposition assessment over portugal
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the portuguese ecthe portuguese ecosystems belong to the most nitrogen n sensitive in the world and are being threatened by n deposition current assessments indicate that the scenarios compliant to the national emissions ceiling nec directive show that this situation is not about to change even with the significant emission reductions planned until 2030 in europe hence the portuguese ecosystems remain at risk but current research and policy support capacity are lacking fonda twinning proposal aims to further develop the expertise of university of aveiro uavr portugal in the field of modelling mapping the emissions transport transformation and deposition of reactive nitrogen nr compounds through a strategic research partnership with tno the netherlands and the free university of berlin fub germany moving towards a highly productive scientific research group understanding the budget of n species is of great importance to better understand the interactionsfeedbacks between atmospheric chemistry biodiversity and climate change the two internationally leading groups are complementary in their orientation towards fundamental science and education fub and applied science and policy support tno together they are responsible for the n deposition mapping for germany and the innovation therein the key role of uavr will be to coordinate this consortium of excellence in the air quality modelling field while developing and increasing its knowledge expertise and reputation on n science besides the strength of uavr excellence in the field of air quality by building a national capacity and infrastructure to independently quantify nationwide n deposition fonda aims to train a new generation of highly skilled researchers by offering innovative education and advanced training programs for researchers in their early career stages develop an innovation framework that is sustainable and allows for strategic collaboration after the project
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equitable resilience solutions to strengthen the link between cultural landscapes and communities
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our common heritage is a central element of our communities and economies and a principal but vulnerable dimension of our common identity as europeans it has been proven that cultural heritage contributes to wellbeing social cohesion identity local economy territorial attractiveness and environmental sustainability but the climate crisis and natural hazards endanger this heritage we propose rescueme to take immediate action for demonstrating how an innovative datadriven communitybased heritagecentric actionable landscape approach to resilience enhancement can protect our cultural heritage and landscapes while supporting the transition toward a green society and economy that sustains resilient cohesive natureconnected communities rescueme proposes a call for action broadening the scope triggering action untapping and mobilizing resources engaging actors and facilitating the decision making and the implantation of cocreated just resilience solutions to protect our common heritage rescueme will develop test and demonstrate the effectiveness of an actionable framework based on the resilient historical landscape approach rhl complemented by data models methods and tools able to assess risks and opportunities codevelop inclusive and just resilience strategies and innovative solutions to protect european cultural heritage and cultural landscapes from climate change disaster risk as well as other stressors such as pollution and overtourism with special focus on european coastal landscapes since a large share of this endangered heritage there the five case studies psiloritis in creta neuwerk in hamburg portovenere cinque terre the islands valncia and the city of zadar have been selected carefully as complementary representatives of european coastal landscapes they will act as resilience landscape laboratories r labscapes validate the results and ensure their replicability
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opioids and insulin secretion a new avenue to fight type 2 diabetes
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type 2 diabetes t2d and obesity are leading causes of morbidity and mortality becoming a major burden on public health failure to understand their pathophysiology has frustrated efforts to develop improved therapeutic strategies t2d and obesity are complex polygenic disorders genomewide association studies have identified hundreds of loci associated with metabolic traits but they have not led to promising new drug targets so far in contrast the identification and characterization of rare mutations causing monogenic metabolic disorders have been instrumental in repositioning or developing drugs beyond this proof of concept the challenge is to use genomic medicine for innovative molecules restoring impaired insulin secretion that characterizes t2doo has stemmed from the old but forgotten correlation between opioids consumption and metabolic trait abnormalities opioids classically act through delta opioid receptor dop encoded by oprd1 kappa and mu opioid receptors based on my preliminary data that include largescale human functional genetics of oprd1 mutations my hypothesis is that dop is a major link between opioids and metabolism in humans more specifically i propose that dop and opioid signaling have a crucial direct role in insulin secretion from pancreatic cells making dop a promising new drug target against t2din this context i suggest four tasks in oo the first two tasks will decipher the role of dop and opioid signaling in metabolism with a specific focus on islets and cells while the two following tasks will decipher the systemic contribution of opioids and opioid receptors to metabolism the methodologies that i proposed are truly comprehensive and innovative as they combine preclinical animal studies with a humanized mouse model deep phenotyping of islets pharmacology multiomic analyses genome editing functional genetics genetic epidemiology including mendelian randomization and clinical intervention study
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federated artificial intelligence for privacypreserving international stratification of colorectal cancer patients
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in the eu 1 in 35 women and 1 in 23 men will be diagnosed with colorectal cancer crc in their life span ca 340000 cases and 156000 deaths in 2020 causing an annual economic burden of ca 20 billion eur identifying crc early enables better treatment options screening usually entails a quantitative faecal immunological test fit to predict the need of colonoscopy for the detection of colorectal lesions an expensive and invasive procedure we aim to predict this need with specificity increased by 20 percentage points by using metagenomic microbiomes we hypothesise that computational microbiome profiles extracted using artificial intelligence al technology will allow for optimised personal therapy stratification however clinicians do not have access to broad microbiome data with microbaiome we will develop a novel kind of computational stratification technology to enable microbiomeenhanced precision medicine of crc metagenomic microbiome data to date is distributed over many national registries and privacy regulations are hindering its effective integration with microbaiome we will overcome this barrier by establishing the first privacypreserving federated big data network in crc research we will integrate isolated national databases into one international federated database network rather than a cloud covering metagenomes for over 5000 individuals screened for crc and an expected total of 100000 by 2026 microbaiome ensures that no sensitive patient data will leave the safe harbours of the local databases while still allowing for the classification of clinical crc phenotypes which we will demonstrate in clinical practice allowing regulatory bodies to adopt evidencebased guidelines our consortium combines expertise in crc and its treatment microbiomics artificial intelligence software development and privacy protection to close the gap between privacy and big data in international medical research
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cardiovascular risk assessment in menopausal women via multimodal data analysis enabling personalized prevention strategies
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womens cardiovascular health is an urgent clinical unmet need as reported by the european society of cardiology esc as cardiovascular disease cvd risk in women still tends to be underestimated by clinicians and women themselves cvd is underdiagnosed undertreated and poorly understood more so in women in the 4060 age group when personalised risk assessment and prevention can have a positive impact on their healthin this context caramel will deliver an innovative personalised prevention model aimed at women 4060yrs based upon a risk assessment stratification model considering sex and gender specific risk factors and a selfassessment and selfmanagement approach using innovative digital technologies empowering women to optimise their cardiovascular health the proposed cvdrisk assessment and stratification scheme will only be possible by the cumulative risk factors analysis fueled by ai emerging from a wide number of different data sources including clinical data from ehr medical imaging biomarkers metabolomics lifestyle information sleep physical activity diet from large cohorts and biobanksa consortium composed by 25 partners and affiliated entities coming from 11 countries composed by 9 clinical entities 6 research organisations and 10 industry and smes will develop test and validate the personalised prevention program in observational and interventional studies in clinical sites in colombia croatia greece lithuania and spain to that end engagement of women aged 4060 will take place from the onset on the codesign and cocreation of the studies and the selfmanagement app ecosystem to be developed likewise gender in research will be mainstreamed all along the interventioncaramel will also deliver policy recommendation and clinical guidelines supporting the design and update of cvd plans by health authorities and healthcare providers considering novel ai based risk models applicable to women aged 4060 yrs
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impact of fermentation on the technofunctional and digestibility properties of oatbased cheese
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the production of highquality plant protein as sustainable alternative for animal proteins is an immediate requirement for the eu population ferotchee is a multidisciplinary project that focuses on the development of fermented plantbased mozzarellastyle cheese using oat protein the challenges associated with the nutritional and technofunctional properties of oat protein will be addressed using innovative solutions a blending oat protein will be partially replaced with pea protein as a complementary source this approach has a potential to create protein hybrids with a balanced amino acid profile b chemical modification enzymatic hydrolysis may improve the technofunctional properties of oat protein it can also lead to the generation of lower molecular weight peptides with healthpromoting effects and c microbial fermentation this will be the main strategy employed in ferotchee to enhance the nutritional quality of oat protein during submerged fermentation microbial strains will be cultivated individually or in a cocultivation setup using an oatenriched protein substrate microbial enzymes eg proteolytic cellwall degrading and antinutritional factor anfdegrading enzymes generated during fermentation will target issues like poor digestibility low recovery and high anf content in oat protein the oat cheese will undergo assessment for technofunctional properties in vitro digestibility biological activities and the level anf the optimised process which results in the production of highquality fermented cheese at the lab scale will be transferred to a foodgrade pilot plant the majority of this project will be carried out at ucd main host the fellow will also engage in two secondments 1 scientific secondment at inraerennes for study of in vitro digestibility using infogest and 2 industry placement at tirln to upscale the process the fellow will also undergo a training plan that encompasses scientific and transferrable skills
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breakthrough brain stimulation device for epilepsy
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easee stands for epicranial application of stimulation electrodes in epilepsy it is the first minimally invasive device for focal cortical stimulation based on the laplace electrode central electrode surrounded by a ring electrode easee features 4 distinct electrodes replacing the outer ring connected to 4 independent current sources to account for impedance and anatomical variances in the human skull still the characteristic quadrupolar local electric field with high penetration depth is maintained the stimulation pattern is one of a kind easee is equipped for high frequency dclike and lowfrequency stimulation depending on the condition to be treated in epilepsy intermittent highfrequency stimulation bursts throughout the day are combined with a 20min dclike stimulation session this first is meant to terminate upcoming seizures the second to initiate neuromodulatory processes to downregulate the overexcitability of the epileptic brain area
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bridging organizations and marginalized communities for local sustainablity transitions in europe
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no european should be put at a disadvantaged because of the european green deal egd bolster will deliver new scientific evidence on decarbonization transition strategies and how they intersect with various dimensions of inequality such as gender race age and class it will conceptualize the principle of leaving no one behind by developing participatory governance models and transition guidelines based on climate justice and gender equality bolster will launch action research in ten european regions seven of those regions are at high risk of being affected by the egd as they have a high concentration of carbonintensive industries the other three regions have already undergone an economic transition and will be studied in order to learn from the past research shows that transition policies predominantly benefit already privileged citizens and often tend to reproduce social inequalities moreover there is a growing polarization visvis transition plans the overall aim of this project is to understand how marginalized communities are affected by egdrelated policies and to see whether involving them in decisionmaking processes increases the support for transition plans to achieve this goal bolster will use novel qualitative research methods with participatory approaches to improve the understanding of the experiences and needs of marginalized communities next it will organize multiactor forums with key actors in the regions in order to enable balanced participation from all social groups special attention will be paid to enhancing the capacities of organizations that represent marginalized groups moreover bolster will actively contribute to addressing procedural justice aspects in the transition process the goal of the multiactor forums is to increase support for the transition plans by better accommodating the needs of marginalized groups we believe that bolsters activities will foster a more just transition
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temporal reconstruction of trna abundance during cortical development in progenitor cells
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the cerebral cortex with its range of specialized excitatory projection neurons is essential to the highorder cognitive functions of the brain these hundreds of subtypes of projection neurons arise from a uniform pool of multipotent apical progenitors aps which sequentially generate neuronal progeny with distinct fates over timerecent technological advances in single cell transcriptomics revealed the existence transcriptional programs that seed neuronal diversity while this working model provides a good explanation for the developmental origin of the distinct neuronal subtypes it is flawed by the existence of some noncorrelating mrnas and proteins indeed a significant fraction of mrna that characterizes mature neurons can already be found untranslated in progenitors the additional mechanisms that coordinate the protein synthesis and ensure correct protein expression in progenitors and daughter neurons have not been identified yet this project focuses on solving the timely question of which mechanisms synergically with transcription are required to refine gene expression during neurodevelopment and cortical patterningto do so we explore the role of translation and its critical adaptor molecule the transfer rna trna in regulating the competency of aps to generate distinct neuronal fate during mouse embryonic cortices development we will generate a comprehensive view of trnas abundance and translation efficiency in aps at ages e12 to e17 this will uncover a novel regulatory role for trnas updating the conventional view of them as housekeeping genes and find new candidate genes for cortical development in both health and disease all in all we will provide a new working model for how neuronal fate and diversity are regulated and opens avenues for future research in other developmental fields where translation has been previously overlooked
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universal platform components for safe fair interoperable data exchange monetisation and trading
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upcast provides a set of universal trustworthy transparent and userfriendly data market plugins for the automation of data sharing and processing agreements between businesses public administrations and citizens our plugins will enable actors in the common european data spaces to design and deploy data exchange and trading operations guaranteeing i automatic negotiation of agreement terms ii dynamic fair pricing ii improved dataasset discovery iii privacy commercial and administrative confidentiality requirements iv low environmental footprint as well as ensuring compliance with v relevant legislation and vi ethical and responsibility guidelines upcast will support the deployment of common european data spaces by consolidating mature research in the areas of data management privacy monetisation exchange and automated negotiation considering efficiency for the environment as well as compliance with eu and national initiatives ai regulations and ethical procedures four realworld pilots across europe will operationalise a set of working platform plugins for data sharing monetisation and trading deployable across a variety of different data marketplaces and platforms ensuring digital autonomy of data providers brokers users and data subjects and enabling interoperability within european data spaces upcast aims at engaging smes administrations and citizens by providing a transferability framework best practices and training to endow users in order to deploy the new technologies and maximise impact of the project
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envelope material system with low impact for zero energy buildings and renovation
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with co2 emission at 36 and energy consumption at 40 building sector is far from sustainability the need for construction materials to achieve climate neutral buildings reaches 02 m3 per m2 of net floor in france leading to several billions of m3 in europe by 2050 easi zero proposes a global system to cut the environmental impact by rising the thermal performance of buildings envelope by 20 with biosourced and recycled materials this include grown mycelium wood fibres low carbon foam recycled raw material for spayed renders multifunctional building bricks and healthy finishes this unique portfolio of tailored components results from manufacturing and sourcing with reduced co2 emission and embodied energy it will demonstrate costefficient and easy installation in green deep renovation and also new construction operations the reuse of components and the integration of recycled materials enhance circular economy by closing carbon cycle and raise resilience in the construction value chain design tools numerical database and material passport will optimise the materials combination towards maximum sustainability and minimum payback time for any typology of buildings and conditions climate aesthetics specific risk projects usecases will show real buildings reaching durable high environmental performance and carbon emission over more than 40 years and neutral energy balance with integrated pv generation where relevant a multidisciplinary consortium will support these objectives and benefit from project outcomes as universities technology developers construction material producers and building engineers usecases will especially consider social housing outcomes will positively impact i european competitiveness with manufacturing of sustainable and clean construction materials and easy installation on any building in eu stock ii raise resilience thanks to circular economy ecodesign and digitization of the easi zero renovation system
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development of a smart shapememory sensor for biological pressure monitoring applications
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hypertension is the leading global contributor to premature death accounting for over 9m deaths worldwide each year elevated blood pressure bp is a chronic lifetime risk factor if left undiagnosed or poorly controlled high bp can lead to serious cardiovascular and cerebrovascular events whereas longterm bp monitoring is required in many highrisk patients there is no clinically accepted method of continuous bp monitoring that can be used outside of hospital settings thus there is an unmet clinical need and a huge market opportunity for a medicalgrade userfriendly and minimally invasive solution for longterm continuous bp monitoring the smartshape consortium has developed and ipprotected a technologically disruptive sensor for continuous pressure measurement however several challenges related to biocompatibility longevity and delivery to the target tissue need to be overcome to deliver the sensor to the market this project will address these challenges by formulation of an innovative biomaterial a novel temperaturedependent shape memory polymer smp the use of smps will enable the development of a microsensor that can be curled up introduced into the body through a minimally invasive procedure and opened up when placed at body temperature to take a predefined shape after integration of the biomaterial in the sensor validation data will be generated for proofofperformance longevity biocompatibility safety and sensor delivery through bench testing and in vivo preclinical studies quality and manufacturing aspects will be addressed and a regulatory strategy and lifecycle assessment delivered bp monitoring will represent the first application but the potential of the sensor goes far beyond that use cases for other healthcare applications such as intraocular or intracranial pressure will be explored which will significantly broaden the potential and marketcreating value of the project results
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an integrated lifecourse approach for personcentred solutions and care for ageing with multimorbidity in the european regions stage stay healthy through ageing
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stage aims to demonstrate the importance and feasibility of a lifecourse approach to prevent accelerated ageing as defined by the accumulation of multimorbidity and to integrate knowledge into transferable personcentred solutions for early diagnosis and screening treatment and longterm management of multimorbidity to achieve this stage is proposing a lifecourse approach to better understand ageing with multimorbidity providing evidencebased solutions to support the transformation of healthcare to address the profound health and demographic challenges ahead the approach capitalises on european collaborations of longitudinal cohorts and biobanks spanning the entire lifecourse actioning exposome and disease networks trajectory analysis as well as the biology of ageing to explore how a person develops ageing with multimorbidity the project objectives integrate an ethical social historical and infrastructural framework environmental epidemiological and biological lifecourse approaches artificial intelligence powered integrated personcentred solutions and applications cohortbased clinical studies and a fair findable accessible interoperable and reusable lifecourse health and geospatial data portal with robust management dissemination engagement and exploitation activitiesstages evidencebased methods will translate into a personcentred prevention and care intervention in longitudinal cohorts in finland and germany codesigned with citizens patients healthcare providers smes and policymakers it will also embed social sciences and humanities and engage stakeholders to develop a neighbourhood healthy ageing index personcentred predictions of multimorbidity and healthcare and policy recommendations ultimately stage will create solutions for agile highquality personcentred health and care services that are lifecourse and gender sensitive needsbased and designed to enhance resilience and participation
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optimizing kiwifruit quality through estimation of leaf stomatal conductance from sap flux density
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most fruit crop irrigation scheduling is performed on empirical basis with very little or no awareness of the consequences on yields and on water use efficiency the main objective of this project is to obtain a model for the estimation of stomatal conductance through sap flux measurement in actinidia allowing assessment of plants water status and correct management of irrigation while optimizing fruit quality this goal will be reached through the following specific objectives i to adjust models for estimation of leaf stomatal conductance of kiwifruit trees from measurements of sap flux density and atmospheric vapor pressure deficit ii to understand which irrigation level optimizes fruit quality and productivity iii to develop precision irrigation protocols based on stomatal conductance estimation this project will lead to innovative results as it will i provide a model to estimate leaf stomatal conductance on an isohydric drought sensible crop kiwifruit with high hydraulic conductance allowing to understand the hydraulic limitations and physiological responses of one of the most water requiring crops ii improve understanding on how a different plant water status and physiological performance at source level affects fruit yield and quality and iii provide a tool to optimize irrigation scheduling of actinidia based on estimated leaf stomatal conductance while reaching these scientific objectives dr fernandes will acquire i research skills by leading the project and being involved in the preparation of further proposal ii teaching skills by holding seminars and tutoring masters students and iii networking skills by participating at several meeting national and international working groups as well as through a strong interaction with stakeholders the exploitation of results will be maximized by foreseen open access results and a wide range of dissemination and communication tools adapted to different target groups
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optimized nanofluids for efficient solar thermal energy production
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as part of its green deal the eu aims to decarbonize energy production by 55 compared to 1990 levels and must turn to renewable energy sources while the northern european countries have some access to these sources they do not have consistent amounts of sunlight for photothermal energy pe generation novel approaches are under development to allow these regions to benefit from solar resources solar radiationinduced boiling in nanofluids can be used for pe steam generation as it facilitates more efficient solar collector technology however knowledge of the mechanisms behind this boiling is severely lacking because the methods to measure these systems are inaccurate at scale and cannot be used for practical opaque nanofluids limiting the focus to macroscopic properties understanding these mechanisms is the key to advancing pe technologies therefore this project endeavours to develop and use new methods to qualify and quantify the photothermal boiling process in nanofluids at the microscale i will move from canada to europe to complete this ambitious project with three specific aims first i will characterize two novel candidate nanofluids plasmafunctionalized graphene and carbon nanofibers massproduced by the project exploitation partner second i will develop new distinct measurement techniques that separate this study from existing ones which only measure temperature and steam flow rate one method will use bubble bursting acoustics to quantity the number and size of bubbles the other will use a medical xray technique computed tomography to image photothermal boiling for the first time finally i will perform boiling tests to determine potential mechanisms and extend the existing models with these objectives fulfilled new information and methodologies will be developed for future research i will gain new skills and competencies to prepare me for a future in industrial research and europe will be onestep closer to a greener future
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cryogenic vibration isolation enabling low temperature scanning probe microscopy in cryogenfree dilution refrigerators
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the project qucom 101046973 is developing a new product that is obviously innovative and easily appreciated advantages to customer the product is a multistage massspring system for passive reduction of vibration noise equipped with heat links and tailored to the requirements of applications working in a cryoenvironment the transfer function of the massspring system is engineered to reflect the cryostat vibrations the heat links are engineered to preserve the cooling power at the experimental stage as well as the mechanical transfer function of the filter the concept of the technology has been proved but further development and improvement of key performance parameters is needed before exploitation moreover a more detailed market study and better understanding of end user needs as well as formulating a mature business case is needed in this booster project we propose to do a more detailed market study and formulating a business case for the use of cryogenic vibration isolation systems cvis in the field of scanning probe microscopy at cryogenic temperatures
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violence and labour discipline in early modern britain
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a 2010 report by the european agency for health and safety at work euosha notes that workrelated violence is a serious issue facing workers today it also results in substantial economic losses through workers demoralized absenteeism and reduced productivity workrelated violence however is not a new phenomenon it has a history viollab seeks to provide the first analysis of the causes and consequences of one type of work related violence in britain c 15501800 disciplinary violence it defines disciplinary violence as fatal and nonfatal physical violence eg beatings that employers or managers used to correct workers infractions and to instil a sense of discipline in them combining methods from social economic and labour history with analytical insights from the sociology of work viollab uses a range of sources to shed new light on how disciplinary violence influenced contemporary practices and theories of labour management gendered and agedbased experiences of work and the legal systems mediation of workeremployer relations by analyzing the causes and consequences of disciplinary violence across different sectors of the british economy as it was transitioning to agrarian and industrial capitalism and becoming increasingly reliant on unfree labour for the production of colonial commodities viollab aims to make transformative contributions to scholarship on work labour relationsdiscipline and the law in a period before the existence of modern labour protection laws and workers organizations and to raise public awareness about problems of work in the 21st century
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sustainable structural sandwiches and hollow composites parts for automotive boat and aerospace markets
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suspens will develop a holistic approach from biosourced and recycled materials to faster and lesser energy demanding processes to produce sustainable composite structural parts ensuring their manufacturability from the design conceptualization this ambition is basically achieved by the rd of the coupling biocircularmaterials and processes suspens will develop up to 95 biosourced thermoset resins with formulations allowing fast cured manufacturing processes and properties adapted to high performance lightweight composite applications to produce the parts these resins will be combined with sustainable continuous reinforcing fibre such as natural based cellulose fibres ligninbased cf recycled cf staple yarn and continuous gf made from recycled gf for producing well engineered sandwich and hollow parts for transport industries some of these parts will be functionalised for added value and reduced assembling times suspens will also develop an innovative approach for sustainable optimized energy reduced pyrolysis using waste stream from the carbonization of precursors reducing environmental impact of carbon fibre production for the bioepoxy a specific solvolysis will be developed to separate the matrix from the fibres suspens will assess the valorisation of oil and organic components in these two recycling approaches to transform them into byproducts lca and lcc studies will show that suspens approaches combining sustainable materials and processes can reduce the co2eq emissions at expected levels of about 4050 these achievements will be validated by producing three demonstrators with their respective business models 1 automotive battery pack for electric vehicle 2 sailing boat hulldeck and 3 aerostructure winglet part suspens results will payback in terms of lesser energy consumption and environmentally friendly products that can be recycled and expects to bring its assets to the market end of 2028
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european cloud for heritage open science
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echoes aims to create the european collaborative cloud for cultural heritage eccch as a shared platform for heritage professionals and researchers to access data innovative scientific and training resources and advanced digital tools codeveloped by the heritage community according to their specific needs echoes will bring together fragmented communities of the cultural heritage ch field which consists of various actors from different sectors and disciplines into a new community around the digital commons going beyond the strict focus on assets and the mere digitisation of heritage echoes intends to generate a visionary paradigm shift in the ch field adopting a holistic approach echoes will also enable digitising the existing knowledge of heritage objects whether tangible or intangible it will create a digital environment enabling collaborative analysis of ch assets facts and phenomena in this environment actors humans or artificial intelligence can develop their interpretations thereby enriching the knowledge of ch and their surroundings the digital environment proposed by echoes will empower users to interact with manipulate and enrich digital twins leading to new jointly developed scientific knowledge the eccch built by echoes is anchored in the principles of open access and open science it thus promotes inclusion and democratises access to knowledge and digital assets which are understood as public goods by and for all this digital environment will allow the creation of a new generation of heritage objects the digital commons which are semantically rich and collectively produced we see this as the heritage of tomorrow at the end of the project echoes will deliver a single platform to integrate results of eu and national projects on ch the eccch will be sustainable thanks to its inclusive legal entity which will be created before the end of echoes
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photoactivated metal oxide transport layers for indoor perovskite photovoltaics
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harnessing indoor lighting available in buildings has the potential to power the next generation of internet of things creating a more environmentally and economically sustainable ecosystem to accelerate future innovation indoor photovoltaics enable this by utilising artificial light sources such as white lightemitting diode and fluorescent lamps to negate the limitations imposed by batterypowered systems among the emerging photovoltaic technologies indoor perovskite solar cells display immense promise and require further study to reach their true potential the electron transport layer an integral part of the perovskite solar cell architecture is of particular interest as its optimisation can lead to overall enhancement of device performance in indoor conditions popular metal oxidebased electron transport layers that offer solution processability tunable electronic properties high carrier mobility and favourable energy level match with the perovskite continue to suffer from high temperature processing and interfacial defects lowering the processing temperature to increase compatibility with flexible devices diversifying the metal oxide family to develop a wider choice of materials and formation of metal oxide composites to augment charge transfer and stability are some measures that can overcome the challenges of the present transport layers and further enhance their properties this study attempts to achieve this by innovatively combining low temperature photoannealing and graphene incorporation to produce high quality films of conventional and novel metal oxides that can be employed in indoor perovskite solar cells to improve overall device efficiency and stability this proposal is a focussed but significant attempt to fill the gap arising from a lack of concentrated study on electron transport materials more specifically inorganic metal oxides in the domain of indoor perovskite solar cells
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artificial intelligence for traffic safety between vehicles and vulnerable road users
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traffic safety is the fundamental criterion for vehicular environments and many artificial intelligencebased systems like selfdriving cars there are places eg intersections and shared spaces in the urban environment with high risks where vehicles and vulnerable road users vrus such as pedestrians and cyclists directly interact with each other by advancing starteoftheart artificial intelligence methodologies this project vevusafety aims to build a privacyaware deep learning framework to learn road users behaviour in various mixed traffic situations for the safety between vehicles and vrus vevusafety proposes a 3d environment model based on 3d point cloud for privacy protection private information like license plates and face is anonymized then within this environment model an endtoend deep learning framework using camera data will be built for multimodal trajectory prediction anomaly detection and potential risk classification based on deep generative models such as variational autoencoder additionally an active privacy mechanism will also be adopted by application of the differential privacy mechanism to help the deep learning models prevent modelinversion attack moreover the frameworks generalizability will be investigated by exploring the normalizing flows approach for domain adaption the frameworks performance will be validated at different intersections and shared spaces using realworld traffic data besides road user safety and privacy vevusafety can help traffic engineers and city planners to better estimate the design of traffic facilities in order to achieve a roaduserfriendly urban traffic environment furthermore the success of vevusafety will enhance the fellows scientific knowledge and project management skills to become an artificial intelligence expert for traffic safety and intelligent transportation systems
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support to the activities of the concentrated solar thermal technology area of the set plan
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the main hurdle the concentrated solar thermal technologies cst sector has been facing over the last decade in europe is the assumed level of the costs of csp power plants with a too narrow perception of its use as flexibility provider to the sole electricity systems to mitigate this the cst4all project identifies an array of hybridisation and cooperation initiatives at the interface between cst and other technologies for applications relevant to the 3 sectors electricity heat and fuels incorporating the work products of various etips wellaligned on current eu initiatives smart sector integration fit for 55 cetp and specific energy strategies across the reviewed member states to provide answers to the most urgent challenges of decarbonisation the core deliverable of cst4all consists of an intertwined set of workshops with respective industry and ri focus these shall bring together better coordinate and incentivise the interaction of main stakeholders at key technology interfaces with the csp sector building on combined technological and nontechnological improvements both the research and the industry perspectives are first analysed aiming primarily at supporting and enlarging the network of active stakeholders in the csp implementation working group in the set plan and to raise the general awareness about the role cst can play in a future sustainable energy mixthese workshops finally result in specific proposals at eulevel from a crosssector perspective to foster publicprivate funding for ri and create the necessary politicalregulatory framework conditions for the execution of the new csp implementation plan
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synthetic antibody synab receptors for the detection and isolation of cyclic depsipeptide cdp toxins in food samples
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food safety plays a critical role in society when it comes to avoiding food poisoning most of the attention goes to preventing microbial growth in food products however the cause of intoxication is the presence of toxins produced by these microorganisms yet standard industrial or household food processing and preparation techniques effective at removing the producing microorganisms fail to remove the actual toxins as a result these toxins which typically are not detected in routine microbial food analysis are consumed daily by the general population beauvericin bea and enniatin b enn b are mycotoxins produced on crops that can easily end up in the final food or feed products other examples include cereulide cer which is produced by bacteria and has a high prevalence in readytoeat foods multiple consequences and even fatalities have been reported due to the consumption of food contaminated with beaenn or cer and as such the detection and sequestration of these toxins is of utmost importance both in public health and economic terms as well as from a broader stakeholder perspectivedespite numerous attempts worldwide the current state of the art does not allow the production of antibodies against cer bea or enn b via classical animal immunization this hampers the creation of a fast robust inexpensive and onfield kitbased detection system for these toxins in food commodities in the current project i intend to use artificial synthetic antibodies synabs that bind to these toxins ionophoric cyclic depsipeptides to produce valuable technologies for detecting and isolating these toxins in complex food samples
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signalling of minor pocket agonists at cxcr4
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the following project smipax4 conducted in the academic group of jeanphilippe herbeuval univeristy of paris france is at the cross section of immunology and pharmacology moreover due to its direct application potential and the subsequent industrial placement to deepen the acquired knowledge at sanofi it is also cross sectional between academia and industry the main objective of the project is to understand the mode of action of small molecules functionally causing a reduction of immune response binding into the minor binding pocket of the g protein coupled receptor cxcr4 the signalling cascade as well as the implication of different expression levels of the target cxcr4 will be explored through different biochemical techniques proteinprotein interactions will be identified using bioluminescence energy transfer bret techniques increase or decrease of second messenger molecules will be identified using biosensors and phosphorylation states up or downregulation of signalling proteins will be measured using flow cytometry or western blotting inflammation of cells when controlling the impact of silencing certain signalling molecules will be controlled by measuring the levels of inflammation markers due to the projects implication in autoimmune and other inflammation diseases it is relevant for cluster 1 health of the horizon europe programme the project shows great potential in the area of impact due to its unique target potentially helping people that do not respond well to already approved medication both the dissemination of results producing multiple publications in peer reviewed journals talks and posters at scientific meetings as well as the potential of creating market within the eu are very probable with completion of this project
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valorising magnetometry in cells
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magnetic resonance spectroscopy nmr or esr and magnetic resonance imaging mri are widely used however magnetic resonance signals are low in energy and thus difficult to detect these techniques are expensive and typically only offer millimeter down to micrometer resolution diamond magnetometry potentially offers a solution the technique is based on a quantum effect and allows even the detection of single electron spins while the technique is already used for a few years in physics during my erc project this powerful tool was utilised for the first time to measure metabolic activity in living cellsthe aim of this project is to explore the commercial potential of these results and if it is deemed feasible found a startup company for exploitation as a first application we will investigate free radical generation these molecules play a key role in many biological processes including cell communication immune responses or ageing additionally they are an indicator for stress and thus play a role in many diseases including cancer cardiovascular diseases or viral and bacterial infections despite their relevance and the fact that free radical generation is often an early sign of disease they are rarely used as biomarkers since they are notoriously difficult to measure in this project we will build a prototype to be patented that can be used for demonstrations to customers this will be done on close collaboration with a user committee in order to meet the customer expectations to demonstrate the usefulness to customers for diagnosis we will conduct test measurements further we will assess whether a business model based on a product or based on services or a hybrid business model containing both is most promising
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robust and accessible modelling for an effective management of agricultural soil erosion in europe
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soil erosion represents a serious challenge for agricultural production and for the environment soil erosion impacts such as reduction of fertile soil alteration of the carbon cycle and pollution and eutrophication of water bodies represent a significant management concern for the european union modelling approaches can deliver indicators on the state of soil erosion impacts and its trends and scenarios in relation to climate and land use change this can help define efficient and targeted mitigation strategies by identifying the longterm controlling factors and the areas where and periods during which soil is at high risk of erosion however to define such strategies there remains a lack of modelling approaches a able to provide with longer term baseline information which to measure the success or otherwise of mitigation strategies at the catchment scale and b accessible and robust enough to be used understood and trusted by users with more or less expertise including researchers land managers and policy makers in response this project will improve improve the robustness and accessibility of quantitative methods for supporting agricultural land management the objectives of this project are i to develop an accessible soil erosion model impacterosion to support agricultural land management in europe at the catchment scale ii to apply a robust and multidisciplinary model evaluation approach to achieve greater confidence in the impacterosion model predictions and iii to identify the soil erosion controlling processes and vulnerable areas and periods to define targeted and effective mitigation strategies until 2100
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striking stroke enhancing and expanding strokealerts business skills
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our vision is to preserve improve the quality of life by reducing silent stroke impact we will develop manufacture and introduce the first easytouse device for alerting stroke for highrisk populations the first market is hospital use during sedation with the endstage market being home telemonitoring the company has a clear patentable product a large growing market and an expert and experienced team strokealerts intellectual property is an alerting system via continuous monitoring of hemodynamic parameters patent submitted strokealerts impact will be reducing morbidity and mortality from stroke we shall compare patients neurological outcomes with and without strokealert
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disrupting purine de novo biosynthesis to fight cancer from molecules to cells to in vivo studies
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according to the who in 2022 there were an estimated 20 million new cancer cases and 97 million deaths the proposed project fits perfectly into the europes beating cancer plan in particular the point diagnosis and treatment and quality of life of cancer patientsthis project combines the expertise of scientists and academic centres from five different countries in three continents who are applying their knowledge at the frontiers of biology chemistry bioinformatics biophysics and medicine to find a specific inhibitor for the atic enzyme involved in de novo purine biosynthesis we have developed a number of new peptidelike compounds and more compounds will be uncovered by bioinformatics tools and will evaluate their efficacy in inhibiting the dimerisation of the enzymeatic monomers the studies will also be conducted in cancer cell lines and in drosophila flies the outcomes can not only improve the health of society but also provide new insights into metabolic pathways in cancer the project will involve young and experienced scientists from eu countries the usa and australia scientists who have previously worked on the interactions of molecules in vitro will learn how to work with animal models and how to conduct in silico studies those who have previously used structural spectroscopy techniques in their work will learn physicochemical methods eg isothermal titration microcalorimetry itc and microscopic techniquesin addition european scientists will have the opportunity to improve their ability to communicate and present their work results in english to enter into new collaborations and to form their own international teams uptodate information about the project will be published on the websites of all consortium partners involved in this project we also plan to organise at least one live workshop every effort will be made to ensure gender balance at all levels of staff involved in the project
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geotechnical derisk by genetic inverse analysis
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mainly funded by taxpayers money the construction industry has a poor track record in sustainability efficiency and safety which are in many cases linked to the lack of understanding of ground behaviour the construction industry is responsible for 11 of global carbon emissions from construction embodied carbon 9 out of 10 projects experience cost overruns 45 of project cost and 60000 fatal accidents in construction yearly geotechnical uncertainty translates to overdesigns unforeseen events and impacts overall safetygeorgia responds to the opportunity to reshape the capital infrastructure and large building projects market by introducing and consolidating the concept of interactive design georgia will enhance the development and commercialization of daarwin as the pioneer endtoend digital platform based on adaptive genetic algorithm to address the ground uncertainty problem and reduce carbon footprint cost overruns and increase the safety of construction projects
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screening and characterization for fast rubisco activating and heat stable rubisco activase to enhance crop photosynthesis and productivity in the future warm climate
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the future warm climate is predicted to reduce crop productivity by decreasing the co2 fixation in photosynthesis which is a concern for global food security co2 fixation in photosynthesis is mainly constrained by an enzyme rubisco rubisco has several inefficiencies including inhibition of its active sites by sugarphosphate derivatives rubisco inhabitation reduces photosynthetic co2 fixation and hence crop productivity and resourceuse efficiency the removal of such inhibitors to restore rubisco activity needs interaction with enzyme rubisco activase rca rca is a crucial heatsensitive enzyme determining the efficiency of co2 fixation by rubisco and hence crop productivity and resourceuse efficiency consequently rca is a promising target to develop productive and resourceuse efficient crops for the future warm climate the limited evidence suggests that exploitable diversity in the speed of rubisco activation and heat stability of rca exists in nature however this diversity is largely unexplored thus hindering our efforts to use rca in crop improvement to fill this gap screenrca will identify and characterize fast rubisco activating and heatstable rca in warm adapted c4 grasses grasses with c4 type of photosynthesis specifically screenrca will use diverse accessions of c4 model grass setaria viridis and c4 model crop sorghum bicolor adapted to a range of temperature gradients these c4 accessions will be exposed to short and longterm warm environments to identify novel fast rubisco activating and heatstable rcas using an intradisciplinary approach melding physiology biochemistry molecular biology and synthetic biology further these novel rcas will be characterized to uncover underlying mechanisms responsible for the efficiency in rubisco activation and heatstability these novel rcas will have utility to develop climateresilient productive and resourceuse efficient crops
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6g intelligent connectivity and interaction for users and infrastructures
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in the context of modern technologies the transition to 6g networks faces numerous challenges therefore novel solutions must be discovered combined and tested in order to achieve distributed smart connectivity imperceptible latency virtually infinite capacity improved securityprivacy smartadaptive networking and energy efficiency the 6gicarus project will investigate combine and improve on current technologies in order to address numerous obstacles that 6g networks will face in order to define the future wireless networks fwns6gicarus is focused on fwns capable of meeting a variety of targets resulting in better geographic coverage particularly in urban areas higher transmission rates lower latency provision of diverse services processing of information generated from a massive volume of heterogeneous sources inherent resilience to counter potential security threats and making intelligent decisions 6gicarus is founded on three pillars i effective utilisation of reconfigurable intelligent surfaces suitably controlled by artificial intelligence software ii channel modelling for mmwavesubthz communications iii multiconnectivity solutions for 6g mobile communicationsthe project will generate novel research results as well as novel original hardware supported by innovative software techniques algorithms based mostly on machine learning and deep learning hardware and software will be combined and examined in realworld settings to fulfill certain situations all of which are matched with realworld applications there will be separate proof of concept studies to validate the technologies and methodologies under consideration
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building momentum and trust to achieve credible soil carbon farming in the eu
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the main goal of the credible project is to build momentum and trust for the implementation of carbon farming in the eu this will be primarily achieved by setting up and moderating a network of initiativesprojectsstakeholders referred to here as the network of networks non for favouring transparency environmental integrity and methodology standardisation in soil carbon accounting such a non will be responsible for pushing forward multiple discussions articulated around three main themes which practises what standards how to monitor and is expected to evolve from a mostly technicalscientific network at the onset of the project into a process catalysing policy making and business innovation toward its end the transparent open access multi actor dialogues required to build trust and cocreate solutions will be orchestrated around three annual european carbon farming summits which will present opportunities for the non to interact with the broader stakeholder community and grow to the point it would attract further fundings for long term sustainability through the action four specific objectives will be achieved o1 to build and disseminate a practical toolbox for promoting carbon farming capable of taking into account local land uses best practices and multiactor interests o2 to identify options for benchmarking and selecting standards certification mechanisms and policy instruments for carbon farming o3 to favour the establishment of a network of soil carbon data collectors and repositories to improve measuring and monitoring carbon dynamics o4 to build up processes and tools to drive conversations for the upscaling of carbon farming credibles ambition is to support the european commission and the expert group on carbon removal in the identification and upscale of solutions for soil carbon farming
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rethinking images as the book of the illiterate towards a new acoustic understanding of religious art 15501650
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aurart investigates auditory perception in early modern religious art by exploring the catholic debate over the gregorian definition of images as the book of the illiterate developed in italy after the council of trent 1563 drawing on a wide range of literary and figurative primary sources such as treatises on the justification of images and contemporary jesuit frescoes the project demonstrates the close interaction between seeing reading and listening in the reception of sacred texts and pictures by rethinking hearing in early modern religious art aurart seeks to fill both a thematic and a methodological gap in the emerging field of study at the intersection of art history sound studies and religion studies the overall goal of the project is to offer a new acoustic understanding of early modern sacred images which will contribute to the current transformative change leading to a new interpretation of art as a cultural phenomenon involving the whole body and its sensorium my research will be supervised by prof ralph dekoninck a specialist in the field of early modern religious art and literature and an expert in artistic theories and sensible practices related to sacred images the fellowship will be hosted at the group of early modern cultural analysis gemca at uclouvain and involves a unique twoway knowledge transfer based on sharing interdisciplinary methodologies for developing new sensory approaches to art history the results will be disseminated through the publication of four articles the development of a website and the organization of two international research workshops aurart also includes the design of a museum auditory device at the musel of louvainlaneuve in collaboration with muriel damien muselgemca the device project involves a synergetic interaction between research artistic creation and sensory heritage mediation with the aim of fostering an embodied acoustic experience of religious artworks accessible to all
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zero emission electric vehicles enabled by harmonised circularity
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zevras main objective is to improve the circularity of lightduty evs throughout their entire value chain from materials supply and manufacturing to endoflife eol processes which aligns with the european unions goal of achieving zero co2e emissions by 2035 particularly in the ev value chain to do so zevra will develop a design for circularity dfc methodology and a holistic circularity assessment aimed at improving the production of electric vehicles evs based on the 9rs this methodology will be validated by developing zero emission solutions for the most important automotive materials covering 84 material mix steel three versions of aluminium wrought casting and foam thermoplastics composites long and continuous fibrereinforced unfiledshort fibre plastics glass tyres and rare earth elements ree these solutions will be supported by a set of digital tools to support the manufacturing of the use cases the assessment of circularity traceability and the virtual integration of components into a full replicable vehicle to maximise the outreach of our methodology and zero emission solutions zevra will develop a dedicated training upskilling programme for the automotive workforce and academia together with activities aimed at increasing awareness acceptability of the proposed zero emission solutions lastly circular business models targeting eol and logistics aimed at improving the economic feasibility of circularity in evs are advanced zevras innovations aim to improve zero emission approaches in the life cycle and value chain of at least 59 of european evs by 2035 through the 5 oems and tier 1s that are part of the consortium which includes industry and academia covering the entire automotive value chain
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welldefined silicasupported titanium catalysts for introducing nitrogen functional groups
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amines are commercially valuable compounds used in a wide range of products including pharmaceuticals agrochemicals and polymers global market usd 166 billion but their industrial synthesis is inefficient and expensive alternatively nitrogen functional groups can be synthesised by green 100 atom efficient reactions hydroamination and hydroaminoalkylation that are catalysed by earthabundant homogeneous ti complexes these reactions are not yet industrially viable due to high costs of catalyst recovery and product purification we need to develop catalysts for these processes that exhibit the high activity and selectivity of homogeneous ti catalysts but are industrially viablethis project will develop new heterogeneous catalysts for introducing nitrogen functional groups by immobilising ti complexes based on homogeneous catalysts for hydroamination and hydroaminoalkylation onto silica surfaces it will blend the disciplines of chemical synthesis homogeneous catalysis and surface organometallic chemistry by using the expertise of researchers and specialist facilities in canada and france i will synthesise novel catalysts featuring welldefined ti metal centres supported by ligands immobilised on silica surfaces optimise their activity for hydroamination and hydroaminoalkylation on industrially important substrates and investigate the mechanism of the reactions to optimise and enhance industrial applicabilitythis project will transform green processes to manufacture nitrogencontaining chemicals from academic research into industrial routes knowledge and key skills in chemical synthesis catalyst development and surface organometallic chemistry will be shared between european and canadian researchers resulting in a synergic partnership impacting academic and industrial fields i will apply my previous experience and learn new technical and transferable skills which will advance me to my goal of becoming an independent academic researcher
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