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characterization of spinal learning in a repetitive yet skilled locomotor task
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animals adjust movement throughout their life to adapt to a changing environment and to learn new motor skills the underlying mechanisms have been studied for decades almost exclusively as a function of the brain interestingly however the spinal cord adapts and learns motor sequences without the brain using only spinal sensory feedback therefore the spinal cord must contain adequate neuronal circuitry for motor learning this project aims to characterize brainindependent mechanisms of learning that take place within the spinal cord with a complete thoracic transection i will functionally isolate the lumbar spinal cord from the brain and enable hindlimb locomotion on a motorized treadmill with pharmacological stimulation using a skilled yet repetitive locomotor paradigm i will identify celltypes indispensable for obstacle learning through circuit manipulation our preliminary data indicate that mice learn to avoid obstacles and improve their performance over weeks we will test the integrity of this performance upon specific and acute inhibition of a selected neuronal population during the behavioral task furthermore using invivo awake eletrophysiological recordings i will characterize circuit dynamics that underlie motor learning capacity attributed to the spinal cord while mice perform the obstacle task this project maximizes the synergies of the host labs expertise ie kinematic analysis circuit dissection and the use of highdensity neuropixel probes and my expertise in electrophysiological recordings in mouse spinal cord in addition to implementing an innovative system of multichannel recordings of spinal circuits in behaving mice knowledge gained from this project will enable linking celltype specific activity profiles in the spinal cord to a motor learning behaviour for the first time this link is an essential yet currently missing piece to understand how the spinal cord contributes to the acquisition of a new motor repertoire
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digital modelling and simulation for design processing and manufacturing of advanced materials
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european materials industry is considered a key enabler for industrial development and the eu has a historically strategic position in this sector however there is a low uptake in european materials industry for digital technologies hereby it is crucial to provide all stakeholders of the eu with advanced digital technologies to evolve towards an agile european materials industry with intelligent enterprises that maximise and integrate the utility of digital materials sciences knowledgedimat will develop open digital tools with a set of advanced technologies for offering european smes and midcaps an affordable in terms of cost implementation and usability full modelling simulation and optimisation system in each stage of the material value chain design processing and manufacturing for improving quality sustainability effectiveness and competitiveness of materialsdimat will deploy 3 integrated suites 1 dimat data and assessment suite digital technologies for storing sharing representing and assessing materials data 2 dimat dimat modelling and design suite digital technologies for material design in terms of their internal structure properties and performance in order to predict the material behaviour before manufacturing 3 dimat simulation and optimisation suite digital technologies for creating efficient materials manufacturing simulation processes and determining the behaviour of the material mechanical characterization models to be used in the ai training and predictionthe dimat suites will be demonstrated in 4 pilots of european designers and producers of different materials textile composite glass and graphite
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the neural and cognitive mechanisms of adaptive and maladaptive emotionbehaviour interactions in naturalistic tasks
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deciding what to do when for how long selforganizing ones behaviour is an important feature of daily life emotions arise providing shortcuts for the computational complexities yet we still know relatively little about the underlying cognitive and neural mechanisms emobb will establish the computational cognitive and neural underpinnings of the rich interplay between emotions and selforganized behaviour in naturalistic environments overcoming three key challenges first previous work has almost exclusively relied on tasks structured into experimenter determined trials thus how people selforganized behaviour could not be measured to overcome this emobb will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measures of emotions this will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviouremotion interactions second many previous decisionmaking tasks have limited relevance for reallife cognition and individual differences emobb will address this by relating the computational task measures to individual differences in reallife behaviours and emotional traits this effort will culminate in the creation of a video game platform providing a large population benchmark third brain imaging has primarily relied on correlations often focusing on individual regions emobb will go beyond this testing the causal role of brain networks and their shifting compositions to cognitive state changes combining functional magnetic resonance brain imaging and noninvasive ultrasound brain stimulation while the challenges are important by themselves combining all aspects in one project will allow a breakthrough in our understanding across all levels from neural underpinning to individual differences specifically it will deliver a model of naturalistic emotionbehaviour interplay and its mediating brain mechanisms
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rapid nanofluidics valves for singlemolecule imaging
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a major challenge in biomolecular research is the investigation of biomolecular interaction at singlemolecule level biomolecules possess heterogeneities of high physiological relevance that can only be unravelled with singlemolecule tools all current singlemolecule imaging methods however require chemical modifications such as fluorescent labelling or immobilization onto a surface which might alter the biomolecules natural behaviourrecently i have developed a groundbreaking optical microscopy method nanofluidic scattering microscopy nsm whose unprecedented resolution enabled me to bypass those limitations and to image individual small proteins in free motion without any label despite these attractive attributes in its current form nsm does not allow for quantitative study of interaction kinetics between individual molecules due to the inherently fast brownian motion the time that a molecule spends on average in the optically probed volume a nanofluidic channel is substantially shorter than the time required to record a statistically relevant number of association and dissociation eventsin this project we will develop an essential nanoscopic component a rapid nanofluidic valve that will enable to confine and release interacting biomolecules to and from the nanofluidic volume the nanofluidic valves will be based on the principles of thermoresponsive polymer hydrogel in combination with nanoplasmonic heating the integration of the nanofluidic valves with nsm will enable to track evolution of individual biomolecules at single molecule level without the need of chemical modifications and in conditions that mimic an invivo statethe project will deliver a unique bioanalytical tool that will make key contributions to the fundamental understanding of biomolecular interactions which is needed in basic research as well as in the pharmaceutical industry
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cooperative cyber protection for modern power grids
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the convergence of information technology it with operational technology ot environments for digitising missioncritical stability and flexibility of electrical power and energy system epes operations as well as new ancillary services as business markets through distributed renewable energy sources dres has undoubtedly expanded the cyberattack spectrum in modern power grids with intrinsic cyberphysical properties to achieve a pragmatic and cooperative cyberphysical protection cocoon brings an interdisciplinary approach consisting of the synergy between networked systems and power systems engineering research with system operations over real setups through cocoon cyber protection in epes should a function optimally and securely b natively provide interdomain secure information exchange c address realtime power systems requirements for timely cyberphysical threat detection and mitigation d enhance operator training for grid protection operations the bottomup systemsoriented approach offered by cocoon will enable the composition of practical datadriven cyberphysical protection mechanisms to operate if needed on realtime and enhance i cyberphysical anomaly diagnosis ii vulnerability assessment and risk profiling iii cyber threat mitigation and iv trustworthy information exchange cocoon will be demonstrated in four distinct pilot studies focusing on detecting classifying and mitigating composite cybervectors targeting i as instrumentation in energy communities through their interface with a dso greece ii crosstso grid stability data updates within the eu south east network coordinator regional based in greece iii dso substations netherlands and iv dres aggregators interfacing with a dso spain
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ecofriendly ytterbiumdoped perovskite nanocrystals embedded in glasses for solar cells
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quantum cutting downconversion materials have emerged as a novel approach to increase solar cell efficiency by reshaping the solar spectrum efforts worldwide have focused on ybdoped lead halide perovskite nanocrystals pncs due to their highly efficient nearinfrared nir photoluminescence pl that matches the bandgap of the commonly used photovoltaic materials however two major challenges limit their commercialization 1 the high toxicity of lead pb 2 the instability of pncs against moisture therefore there is a need to develop ybdoped pbfree pncs and embed them in dense structures like glass to increase their chemical stability over time to this end the interdisciplinary nebulae project aims to develop new fluorophosphate fp glassceramics gcs that contain ybdoped pbfree pncs it will be the first to report not only pbfree pncs in fp glass but also ybdoped perovskite fp gcs for solar cells thus 1 ybdoped fp glasses will be synthesized using the meltquenching method and characterized by a complex of spectroscopic methods to study the compositionproperty relation 2 nucleation and growth will be investigated and heat treatment will be conducted to obtain transparent gcs with enhanced nir pl in which ybdoped pbfree pncs are embedded in the volume of the glass 3 the gcs will be tested in a solar cell to demonstrate proofofconcept improvement in cell performance nebulae is based on the pis expertise in optics the supervisors in glass science and the cosupervisors in solar cells ensuring the achievement of the research goals dissemination and exploitation of the results the trainingresearch activities will equip the pi with the skills needed to apply to erc starting grant andor obtain a tenure track in the eu which will allow the pi to launch his own research group nebulae contributes to un sustainable development goals and eu green deal by reducing the use of toxic elements and promoting clean energy
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heterojunctions of topological insulator and metal organic frameworks for thz detection applications
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today xray detection techniques are widely used in the homeland security such as airport surveillance and custom activities and in the medical diagnostics however xrays are ionizing can provoke cancer like diseases and moreover they are unable to detect fabric plastic and concealed hazardous materials the terahertz thz technology has a potential to solve these problems however mainly due to the low photon energy of thz waves it is still difficult to accomplish highspeed and sensitive room temperature thz detectionthe proposed work aims to advance the thz detection technology by exploring exciting optoelectronic properties of topological insulators tis metal organic frameworks mofs and their interfaces i will focus the research on the design and fabrication of heterojunctions consisting of ti thin films and semiconducting twodimensional mofs and on the optimization of their electronic properties and interaction strength with thz radiation to address the enhancement of lightmatter interaction in these novel devices i will vary the chemical composition of mof layers thus enabling the control of their crystalline order and of the coupling between organic and inorganic components tis surface properties will then enhance the charge carrier transport at the interface due to topological protection against the carrier scattering these ingredients will allow tuning and optimization of the photocurrent generation upon absorption of thz photons ie of the photodetection processthe project will answer questions of the physical mechanisms of charge carrier transport in mofs and at timof interfaces and of the key parameters for an enhancement of optoelectronic properties in timof heterojunctions
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machine learning methods for the reconstruction of dual tracer pet images
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positron emission tomography pet is a medical imaging technique that displays in vivo brainwide metabolic processes prior to pet image acquisition a tracer labelled with a positron emitting isotope is injected to the patient this socalled radiotracer distributes over the body and accumulates in eg inflammatory tissue to date the acquisiton of a pet image is limited to one tracer thereby only displaying one metabolic process in the brain however the acquisition of two separate pet images acquired with different tracer simultaneously would give novel and unique insights in the communication between eg neurotransmitter systems these insights could be used for the development of new drugs for eg alzheimer patients and would increase the understanding of the healthy and diseased brainthe acquisition of dual tracer pet images can be achieved by combining two radiotracers with different properties the first standard radiotracer emits two photons that are recorded by the pet system while the second nonstandard tracer emits two photons and an additional gamma ray by identifying the additional gamma ray the photon detections of the two tracers can be separated and two pet images can be reconstructed dual tracer pet image reconstruction yields challenges due to undesirable effect of photon detection in this project a machine learning algorithm will be trained to detect and correct for these effects moreover the image acquired with the nonstandard tracer yields low image quality a convolutional neural network will be trained to denoise this pet image in the proposed project a reconstruction algorithm for dual tracer pet based on machine learning techniques and resulting in two separate pet images with high image quality will be developed and implemented the proposed project will demonstrate if dual tracer pet imaging has future potential and will help to understand the highly interactive neuronal communication in the brain
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a ferrosilicon latent heat thermophotovoltaic battery
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thermobat will develop an innovative latent heat thermophotovoltaic lhtpv battery for long duration storage 10 to 100 hours and combined heat and power chp generation the system stores electricity in the form of latent heat at very high temperatures 1200 deg c using a new kind of ferrosilicon alloy with very high energy density 1 mwh per m3 and converts it back to electricity and lowtemperature heat 70 deg c ondemand using solidstate thermophotovoltaic tpv devices the value proposition is the supply of a very cheap system 10 euro per kwh that has a very high energy density 400 kwh per m3 high global efficiency 90 that is safe flexible compact silent recyclable scalable and able to produce clean heat and electricity on demand the dispatchable chp generation capability of the lhtpv battery will be demonstrated in a sport center that is managed by one of the largest spanish companies dedicated to the design maintenance and operation of infrastructures thermobat builds on the results demonstrated proof of principle achieved within the fetopen project amadeus in which a small labscale prototype of the system was built and tested thermobat will bring lhtpv technology closer to commercialization by developing scalable lowcost and environmentally friendly processes for the manufacturing of the key components of the lhtpv battery in addition we will focus on accelerating techtomarket activities through thermophoton a recently established upm spinoff company that will receive upms knowhow and will develop a detailed business plan to make the innovation fully marketable this techtomarket plan is also a continuation of another eu funded project named nathalie fet innovation launchpad in which the market and the potential application of the invention on industrial commercial and institutional buildings have been analyzed
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supporting the identification of policy priorities and recommendations for designing a sustainable track towards circular biobased systems
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the transition from linear fossilbased systems to circular and biobased systems represents an opportunity and a suitable pathway for achieving several sdgs indeed circular biobased systems depict a great opportunity to reconcile sustainable longterm growth with environmental protection through the prudent use of renewable resources for industrial purposes this needed transition is a complex process which does not simply require innovative technologies from the supplyside but also societal transformations based on a multiactor process the circular bioeconomy metasector may be a good candidate to put forward a new economic model which requires transformative policies purposeful innovation access to finance risktaking capacity as well as new and sustainable business models and markets however a critical assessment of the environmental social and economic impacts of the current linear fossilbased economy as well as of the improvement potential associated with circular biobased systems is needed to underpin the identification of policy priorities bearing this in mind sustrack is a threeyear project aimed at supporting policymakers in their efforts to develop sustainable pathways to replace fossil and carbonintensive systems with sustainable circular and biobased systems at the eu and regional scale contributing to achieving the european green deals objectives this will be done by identifying environmental economic and social limits of a linear carbonintensive and fossilbased economy improving existing assessment methodologies assessing the environmental social and economic impacts of the eus current linear fossilbased economy comparing multiple transition scenarios focusing on the most carbonintensive sectors identifying priorities according to scenarios analysed in the project and develop guidelines and policy recommendations
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eu farmers pig welfare innovation network
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welfarmers will set up eight national innovation networks and four europewide networks of pig farmers advisors veterinarians and researchers to address the challenges of the upcoming change in the european pig welfare legislation welfarmers will address four main topics cage ban keeping pigs with uncovered tails avoiding pain during castration and space and flooring the most urgent innovation needs and challenges will be identified in a bottom up way and the network will collect and evaluate good practices that meet these needs welfarmers will also strive to collaborate with existing and new eipagri operational groups ogs and eu research projects focused on pig welfare and to enhance their impact the selected best practices will be disseminated through a series of communication and dissemination activities to reach most pig farmers in the eight participating countries and in europe eip abstracts thematic reports videos brochures enews national workshops transnational crossfertilisation events and a multilingual website are some of the dissemination methods planned to communicate and disseminate the best practices
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scientific largescale infrastructure for computingcommunication experimental studies preparatory phase
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the digital infrastructures research community continues to face numerous new challenges towards the design of the next generation internet this is an extremely complex ecosystem encompassing communication networking datamanagement and dataintelligence issues supported by established and emerging technologies such as iot 56g cloudtoedge computing coupled with the enormous amount of data generated and exchanged over the network this calls for incremental as well as radically new design paradigms experimentallydriven research is becoming worldwide a defacto standard which has to be supported by largescale research infrastructures to make results trusted repeatable and accessible to the research communitiesslicesri research infrastructure which was recently included in the 2021 esfri roadmap aims to answer these problems by building a large infrastructure needed for the experimental research on various aspects of distributed computing networking iot and 56g networks it will provide the resources needed to continuously design experiment operate and automate the full lifecycle management of digital infrastructures data applications and servicesbased on the two preceding projects within slicesri slicesds design study and slicessc starting community the slicespp preparatory phase project will validate the requirements to engage into the implementation phase of the ri lifecycle it will set the policies and decision processes for the governance of slicesri ie the legal and financial frameworks the business model the required human resource capacities and training programme it will also settle the final technical architecture design for implementation it will engage member states and stakeholders to secure commitment and funding needed for the platform to operate it will position slices as an impactful instrument to support european advanced research industrial competitiveness and societal impact in the digital era
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locating literature lived religion and lives in the himalayas the van manen collection
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this project offers an ambitious study of an important yet mostly forgotten collection of himalayan texts and artifacts collected between 1920 and 1940 it will for the first time provide a view of the van manen collection through a study of its rare manuscripts the material objects undocumented marginal writings and the unique tibetan language autobiographies by ordinary himalayan people commissioned by van manen this collection held in the leiden university library contains a large number of tibetan and himalayan texts collected by johan van manen who lived in india after his death in 1943 a large part of his personal collection became housed at the university totaling more than 1500 mostly tibetan texts he also collected himalayan artifacts now stored separately from the texts in museum volkenkunde in leiden the texts and artifacts reflect the collectors interest in the lived religion and the lives of himalayan people the projects goal is the examination of the van manen collection as a whole using historical ethnographic and philological methods and by employing digital humanities methods through which the origins of the texts and artifacts can be traced mapped and be made available linking them to other editions in online databases as well as to local tibetan archives the main aim is to get an understanding of the proliferation usage and presence of religious and ritual literature and artifacts in the greater darjeeling area in the first half of the 20th century and by extension their religious milieus 1 many of the texts are unica in tibetan literature and as they are mostly unstudied they merit a thorough examination 2 the broader question is how to read and engage with a multi media collection curated by one single collector and how to understand the collection formation process 3 the project results will contribute to the analysis of multimedia collections of nonwestern literature and material culture 4
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manipulating nonlinear sound waves using nonhermiticity and active control nonlinear and active sound absorption
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audible sound is an inevitable physical phenomenon which can be the best or the worst of all things in its best form is essential to human communication and entertainment in its worst form it appears as a social and health threat through noise in urban and domestic environments arising from sources such as vehicles ventilation systems construction sites and aircraft engines both european and international organisations identify noise as a major health issue of modern society and insist on regulating its levels some modern noise reduction solutions using artificial periodic composites and benefiting from the 3d printing techniques do exist however an important problem regarding sound absorption still remains unsolved and unexploredhigh amplitude nonlinear waves cannot be absorbed using the existing conventional techniques and devices these high amplitude nonlinear waves in fact pose an even larger problem than noise when they appear in applications such as power plants or gas transport systems they can cause significant environmental reliability and safety problems stemming from vibration and structural fatiguein an original perspective the nasa project will utilise recent results from nonhermitian physics to tame and absorb high amplitude nonlinear sound waves the project strives to uncover the main sources of nonlinearity in acoustic isolation solutions and to use active nonreciprocal scatterers in unison with modern concepts such as topological physics proposing an unconventional way to efficiently absorb nonlinear acoustic waves nonlinearity which is known to lead into chaos and randomness when in conjunction with nonhermiticity raises fundamental questions and their synergy may revolutionise our ability to control waves within nasa i aim develop novel design principles and tools which will foster the development of efficient adoptable and reliable noise reduction technologies particularly in heavy industry and aviation
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ferbopo fostering excellence in research on statechurchbody politics
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the ferbopo proposal aims at building a new research group at lucian blaga university of sibiu lbus focused on the complex relationship between state church and body politics that would foster excellence in social sciences and better integrate lbus in the european research area era to this end lbus will create a chair position for professor lavinia stan from st francis xavier university canada whose outstanding academic profile and thorough expertise in the crosscutting fields of government religion economics and epistemology that foster decolonial feminist thinking lugones 2010 manning 2021 and the institutionalisation of gender studies in romania turcescu and stan 2005 stan 2010 will help increase the number of excellent research staff and improve their capability to attract competitive research funding with significant spillover effects at societal level while also assisting lbus to implement institutional reforms that both align with era priorities and facilitate the implementation of the gender equality plan gep the main objective of this ferbopo is to create a pocket of excellence in lbus by attracting outstanding scientists with internationally mobile academic careers so as to improve the host institutions organizational culture and the academic outputs of lbus scholars romanian higher education institutions continue to lag behind their western counterparts in their governance effectiveness and academic performance indicators dobbins 2017 an acute scientific production deficit is related to gender studies vlase and terian 2023 by creating the new chair and research group the proposed era chair will help lbus to near european standards of academic performance and institutionalisation of gender studies through the employment at lbus of the era chair holder ferbopo will contribute to the creation of a knowledge hub in the university in particular and the romanian higher education system in general
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evolution of advanced luminescent technology software
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by 2050 the european union aims to become climateneutral developing into an economy with netzero greenhouse gas emissions this objective is considered both an urgent challenge at the heart of the european green deal and an opportunity to improve society to achieve this ambitious objective we need to develop and implement new technologies that target the largest energy consumer in the eu buildings collectively buildings in the eu homes workplaces hospitals schools account for 40 of the total energy consumption and generate 36 of ghg at the different stages of their lifetime construction usage renovation demolition within the erc proof of concept evolute we will develop a software platform that enables the optimisation of various geometrical shapes and sizes of luminescent solar ls devices which is expected to have several advantages a it has the potential to improve the efficiency and functionality of buildingintegrated photovoltaics b visually appealing photovoltaic panels at lower costs than todays state of the art c better and efficient utilisation of solar energy d simplified and minimise the cost of ls devices fabrication e develop a comprehensive and efficient light management technology f more comprehensive and broadened applications of ls technology evolute aims to synchronise technical development and feasibility with commercial viability and to ensure that the unique selling points of our software are fully aligned with the market requirements the project plan is designed optimally to achieve technology readiness level 5 from 23 currently and enable us to continue its development within for example an eic transition
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reliability and risk assessment of flexible modular structures with vibration control devices in multihazard environments
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development of sustainable and resilience infrastructure is very important because particularly in europe building structures are accountable for materials extraction co2 emissions and energy consumption the decline of residential building impacts is one of the crucial goals identified by the european union eu to meet the paris goals and move forward for circular economy therefore reliability and risk assessment of flexible modular structures with vibration control devices in multihazard environments readmode project proposes an innovative approach to analyze the reliability and risk of modular structures in this project a probabilistic approach is considered to increase the accuracy of structural reliability and risk assessment it contains the development of improved mathematical models for the reliable and resilient infrastructures also a detailed novel solution will be given for enhancement of resiliency in the modular buildings the output of this research will provide costeffective and timesaving techniques for resilience improvement the fellowship will lead to closer cooperation and knowledge transfer between researchers at host and between different sectors the research findings specifically and my personal enhanced competencies generally will lay the groundwork for future theoretical study in resilient infrastructures most european countries are already developed and contain many existing structures and infrastructures that need to be resilience this will prepare authorities for potential changes in design approach and calculations for future projects and will have significant impact on understanding the risks and safe design of resilient infrastructures
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smart textiles made from agriculture and natural waste materials
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the main objective of the smartwaste msca se project is to form a world class international and intersectoral network of organizations working on a joint research programme in the field of novel sustainable smart textile materials by replacing conventional and high costs textile materials with sustainable environmentally friendly cheaper and novel materials such as cellulose fibres from tomato stems waste and creating nonwovens from unconventional poplar seed fibers this can only be achieved by bringing together worldclass experts in materials polymers environmentalists chemists software engineers and designers with stateoftheart innovations and processes in their respective fields of expertise the participants will exchange skills and knowledge to create sustainable textile materials strengthening collaborative research between different countries and sectors smartwaste will also refine and produce potential commercial market opportunities for nonacademic participants in the project wp7 our goal is to train next generation of researchers and innovators in sustainable textiles through crosssectoral and training modules the staff members will develop new skills be exposed to new research and innovation environments international networks new industrial processes and techniques whilst widening and enriching career development through crosssectoral knowledge transfer and international mobility
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aluminium oxide integrated photonic platform for applications in the ultraviolet uv
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the goal of aluvia is to establish the first european al2o3onsio2 aluminum oxide on silicon dioxide integrated photonic platform for operation in the ultraviolet uv wavelength region the platform will be commercialized as a foundry service via the spinoff company of the pis group aluvia photonics bv which is founded in the framework of the erc proofofconcept project asindo the platform will contain a comprehensive library of widely deployable building blocks that will be offered commercially an integrated photonic packaging technology will be developed for operation down to ultraviolet wavelengths as a testbase and driver for the developed building blocks and packaging technology we will utilize the aluvia platform in two application fields that have promising commercial and scientific potential namely 1 an integrated sensor for uv resonant raman spectroscopy and 2 an integrated multipleion trap for the parallelization of onchip quantum qubit generation one of the most advanced quantum computing technologies today
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design synthesis and applications of phosphatwistednanographenes
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nanographitic molecules ngs are pivotal for existing microelectronics and the development of emerging technologies wearable electronics artificial skins and nerves etc their outstanding semiconducting properties rely on the efficient overlap of their carbonscaffold and the spatial disposition of molecules if we could twist the planar framework of ngs diversify their piscaffold with heteroatoms while keeping control over the molecular organization we could modify their properties and access innovative materials with uncharted research opportunities for organic electronics through an innovative approach i target to insert phosphorus heterocycles into twistedngs as tools to tailor their properties and meticulously control their molecular arrangement with phosphatngs i will provide a highly versatile protocol for the preparation of novel twisted phosphangs thanks to the unique chemistry of phosphorus i aim at establishing an unconventional methodology to sequentially organize ngs into hierarchical architectures my groundbreaking approach will lead to materials that were inaccessible to date as organophosphorus chemistry was too immature so far through an arsenal of spectroscopic techniques i will achieve the first comprehensive investigation on the impact of heteroatoms into the twistinginduced properties of ngs the outcomes of phosphatngs will have a wide range of applications here i will test selected individual and assembled phosphangs as chiroptical materials and as prototypes of fieldeffect transistor sensors laying the foundation for new research opportunities in material science thus phosphatngs will consolidate the bedrocks for new cuttingedge fields of research whose development will clearly extend beyond the timescale of this proposal
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embodied social experiences in hybrid shared spaces
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sharesharespace will demonstrate a radically new technology for promoting ethical and social interaction in extended reality xr shared hybrid spaces shs anchored in human sensorimotor communication our core concept is to identify and segment social sensorimotor primitives and reconstruct them in hybrid settings to build continuous embodied and rich human avatar experiences to achieve this three interconnected sciencetowardstechnology breakthroughs will be delivered novel computational cognitive architectures a unique selfcalibrating body sensor network and a fully mobile spatial augmented reality ar and virtual human rendering we will create a library of social motion primitives and use them to design aibased architectures of our artificial agents sharespace mobile capturing technologies combine looselycoupled visualinertial tracking of full body kinematic hand pose and facial expression incorporating novel neural encodingdecoding functionalities together with local contextaware animations and highly realistic neural rendering our technology will be iteratively tested in 2 proofsofprinciples involving human and artificial agents interacting in shs and 3 realworld use case scenarios in health sport and art we will demonstrate a fully functional prototype of sharespace tailored to the agents personalized characteristics gender culture and social dispositions sharespace will support communitybuilding and exploitation with concrete initiatives including i public engagement around our research and innovation ii promoting hightech innovation and early transfer to our deeptech companies as premises for the consolidation of humancentric and sovereign european market areas such industry ar and shs ehealth and telehealth our longterm vision is to bring xr to a radically new level of presence and sociality by reconstructing sensorimotor primitives that enable ethical trusted and inclusive modes of social interaction
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brisk rydberg ions for scalable quantum processors
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the goal of brisq is to realize a prototype of a fully scalable quantum computer which has the capability to run quantum algorithms with a circuit depth exceeding one million achieving this goal will deliver a breakthrough in quantum information processing and simulation this will directly impact on current efforts of the industrial sector which seek to employ quantum technology for computational tasks such as the design of materials and drugs or various optimization problems tasks that are also limited by possible computational depthour technological approach exploits the interaction of trapped ions excited to electronically highlying rydberg states the distinctive advantage of this platform is that it offers coherence times in the range of up to a minute together with fast entangling gate speeds on the order of 100 ns these two factors are key for achieving an unprecedented circuit depth and thus computational complexity research on rydbergion devices is performed solely in two european research labs and the first nanosecondtimescale entangling gate based on this approach has been achieved by one of the members of the brisq consortium this brings the consortium in a unique position and gives europe a decisive lead for advancing the development of this new platform towards maturity to facilitate this effort the brisq project assembles a research consortium that consists of two experimental and two theoretical academic research groups they are joined by the sme hqs and the industrial partner infineon technologies this combination of expertise permits us to advance our ambitious project on a broad front ranging from industrial grade hardware to userdriven quantum algorithms and compiler software which can directly feed into simulation of physical models and potentially quantum chemistry
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magnetogenesis from axionsu2 inflation and applications to gravitational waves
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magnetic fields are ubiquitous in our universe the question of their origin and subsequent evolution is a challenge for moderncosmology recent bounds on magnetic fields from blazar observations together with the requirement for initial seed field for dynamo and compression amplification mechanisms motivate the study of possible primordial origins of magnetic fields this project combines expertise in early universe physics with an expertise in astrophysics magnetohydrodynamics and advanced numerical tools to study the production of magnetic fields in models of axion inflation coupled to the standard model of particle physics socalled axionsu2 inflation the results of this project will trace the origin of magnetic fields from the early to the presentday universe and confront the axionsu2 magnetogenesis by crosscorrelating cosmic microwave background and blazar observations to achieve this i will go beyond the current understanding of the simpler socalled axionu1 magnetogenesis models widely studied until now and study the viability of chiral magnetic field production in the axionsu2 case furthermore i will develop new numerical tools to determine how the presence of feedback mechanisms affect magnetogenesis i will also compute the spectrum of gravitational waves generated by axionsu2 models in the radiationdominated era of the early universe and compare it to other known sources of gravitational waves such as cosmic strings to understand potential differences in the observational predictions my experience in early universe physics together with the present worldleading expertise in magnetohydrodynamics at nordita make it an ideal place for a twoway transfer of knowledge essential for the implementation of this project this project aims to bridge astrophysics and early universe physics and to develop cuttingage numerical tools that may also be applicable in quantum physics and condensed matter physics
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precision biomarker based on digital pathology and artificial intelligence to guide fast and costeffective personalized treatment decision support for colorectal cancer patients
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there is consensus in the oncology community that there is a large need for personalized cancer treatment decisions as patients suffer from largescale overtreatment up to 90 of patients receiving adjuvant chemotherapy have no effect many suffer severe side effects domore diagnostics domore dx delivers pioneering diagnostics software that enables personalized cancer treatment in a simple and costefficient way we provide deep learning algorithms applied to cancer tissue whole slide images wsi in the adjuvant chemotherapy setting with endtoend deep learning we have taken a completely new approach to this challenge our test can be run in local labs with digital pathology equipment and does not consume any tissue domore dx is personalized medicine made simplein crc our test can stratify patients into low intermediate or high risk with a hazard ratio 10 this information can be used to take up to 250000 patients out of chemotherapy and save 4 billion eur globally every year
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development of an invivo brillouin microscope with application to protein aggregationbased pathologies
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the role and importance of mechanical properties of cells and tissues in cellular function development and disease has widely beenacknowledged however standard techniques currently used to assess them exhibit intrinsic limitations invasive lack of 3d capabilityand of subcellular resolution recently brillouin microscopy bm a type of optical elastography has emerged as a nondestructivelabel and contactfree method that can probe the viscoelastic properties of biological samples with diffractionlimited resolution in3d this led to increased attention amongst the biological and medical research communities however due to the long acquisitiontime hours this novel technique has been applied only to fixed samples one important open challenge is to use this approach tofollow the mechanobiological processes in living cells and in real time aim of our project is overcome the spectralimagingacquisacknowledged however standard techniques currently used to assess them exhibit intrinsic limitations invasive lack of 3d capability and of subcellular resolution recently brillouin microscopy bm a type of optical elastography has emerged as a nondestructive label and contactfree method that can probe the viscoelastic properties of biological samples with diffractionlimited resolution in 3d this led to increased attention amongst the biological and medical research communities however due to the long acquisition time hours this novel technique has been applied only to fixed samples one important open challenge is to use this approach to follow the mechanobiological processes in living cells and in real time aim of our project is overcome the spectralimaging acquisition time limitation by applying the heterodyne detection scheme allowing the collection of viscoelastic properties in living sample at a subsecond timescale we will attempt solving specific physiopathological open problems in biomedicine for the first time
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lights in the nightsky and ozone loss unravelling atmosphere forcing from space with radar optics and novel citizen science
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this project will address a major unsolved question in geosciences how strongly is our planets atmosphere subjected to forcing from space the mesospherelowerthermosphereionosphere mlti is the boundary of the earth environment and as such it undergoes forcing from above in particular at high latitudes the forcing includes charged particle precipitation from nearearth space associated with electric currents producing joule heating in the upper atmosphere it also involves trace gas production in the mesosphere which catalytically destroy ozone including down to the stratosphere when longlived species descend to lower altitudes as well as neutral wind changes and atmospheric wave generation however these effects in terms of mlti energetics chemistry and dynamics are largely unquantified leading to unknown uncertainties in lower atmosphere and climate model results the louarn project will bridge this gap by adopting a multidisciplinary approach combining knowledge and methods from space physics and atmosphere sciences with louarn i aim at unravelling the mlti forcing from space by using cuttingedge groundbased instruments measuring both the ionised medium and the neutral gas properties together with numerical simulations of the upper atmosphere and novel citizen science methods my objectives are to 1quantify the energy deposited into the mlti during geomagnetic disturbances 2provide accurate upperboundary conditions on the ozone balance for atmosphere and climate models and 3characterise the wind and atmospheric wave response to this driving from space my expertise in ionospheric physics and its driving from nearearth space processes along with my leadership in auroral citizen science puts me in an ideal position to address this ambitious challenge i aim at a breakthrough in atmosphereionospherespace couplings with impacts on atmosphere and climate sciences and on solarterrestrial physics
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scientific training programme for advanced research and knowledge in lightmatter engineering
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sparkle will build a mixed experimental and theoretical network to develop the necessary tools and techniques to exploit lightmatter coupling to manipulate materials functionalities sparkle will bridge the gap between photonics on the one hand and materials science on the other by advancing the understanding of lightmatter interaction via two distinct yet complementary approaches i the utilization of tailored laser fields and ii the confinement of light in optical environments called cavities the network will connect leading academic and industrial experts to push the development of novel detection techniques innovative light sources stateoftheart abinitio simulation methods and innovative designs of lightmatter hybrid solidstate systems for devices at the interface of photonics electronics and quantum technology we are convinced that this topic is mature enough to provide europe with a first generation of 14 early stage career scientists trained on interdisciplinary and intersectoral aspects of light and matter based technology while at the same time pushing forward a cutting edge research field the one of polaritonics sparkle will follow the guiding principle of model simulate design measure providing the doctoral candidates with a unique multidisciplinary training which will place them at the forefront of the research on lightmatter hybrid systems they will collectively engage in a scientific endeavour the control and manipulation of the quantum nature of material and light that bridges the domains of theoretical solid state physics quantum optics ab initio material simulations photonic engineering laser physics and ultrafast spectroscopies last but not least the doctoral candidates will be equipped with the required entrepreneurship innovation organizational soft and management skills to become successful future leaders in both academic and industrial environments
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national engagement activities to support the launch of the mission a soil deal for europe 100 living labs and lighthouses
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nati00ns will assist the eu mission a soil deal for europe during most of its first induction and pilot phase 2021 2025 acting as a messenger and conveying awarenessraising messages to national and regional stakeholders providing access to capacity building materials and information spurring the discussions on the best livinglab ll setups to address regional soil needs and fostering early matchmaking for crossregional ll clusters eventually the smooth execution of the project will be reflected in the number of highquality applications received in the first open calls and the funding of the first two waves of ll projects which can lead the way for the systemic change boosted by the soil mission the takeaways will be also useful for upcoming activities in the soil missions second expansion and innovation phase 2025 2030 when the rest of the waves of lls will be selectednati00ns consortium has been carefully selected and formed with the intention of gathering and covering all the necessary expertise needed to ensure the successful execution of the work plan and achievement of the projects objectives this will in turn allow the partners to contribute to the soil missions expected impact on society following the achievement of its objectives and goal on the one hand the project is counting on top experts on soil science and the coparticipatory placebased innovation approaches to be put in place in the living labs on the other hand nati00ns is granting adequate national outreach in all eu member states and horizon europe associated countries through its 14 partners its key network group representatives and all their networks ie bioeast european network of living labs soil health national hubs eriaff etc
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the first european digital health technology assessment framework cocreated by all stakeholders along the value chain
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digital health technologies dhts are expected to improve both the quality and delivery of healthcare services for european societies while ensuring the sustainability of europes healthcare systems dhts are also able to collect realworld data and evidence relevant for decision makers however the implementation of dhts implies new methodological challenges to the standardisation of assessment criteria existing health technology assessments htas are unable to capture the real added value of dhts edihta will be the first flexible inclusive validated and readyforuse european hta framework reaching trl 67 allowing the assessment of different dhts eg telemedicine mapps ai at different trls territorial levels national regional and local and perspectives eg payer society hospital all relevant stakeholders will contribute to its design development and validation the digital framework will be piloted in real healthcare settings in 5 major european hospitals and through an open piloting scheme with european dht developers the principles of edihta are to 1 promote a holistic approach involving all stakeholders for consensus building at national and european levels 2 define a common terminology harmonise and enrich existing hta frameworks and create an open repository with frameworks guides articles and hta methodologies 3 optimise assessment processes along the dht life cycle 4 follow a multistakeholder multidomain and modular approach 5 cocreate edihta solutions and 6 provide a validated and readyforuse digital hta framework for dhts next to leading academic groups in hta research our multidisciplinary consortium includes hta agencies clinics as dht endusers technology providers and a patient organisation with links to the broader european healthcare landscape of regulatory bodies policymakers and payers edihta will leverage its network to accelerate the market entry of new dhts for the benefit of european society
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colloidal indium arsenide quantum dots as shortwave infrared single photon emitters
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moonshot aims at developing a novel singlephoton emitting material that operates in the telecommunication wavelength range 13001600 nm o and cbands and is compliant with the restriction of hazardous substances in electrical and electronic equipment rohs the main motivation for such objective is that singlephoton sources based on epitaxial quantum dots qds are now a mature technology available on the market that is outperforming laser cooled atoms or spontaneous parametric down conversion via nonlinear crystals yet three major issues afflict epitaxial qds first the epitaxial approach presents drawbacks in terms of limited throughput and cmos incompatibility secondly often the emission wavelength of epitaxial qds for singlephoton generation is limited to less than 1000 nm finally singlephoton sources based on this class of qds require lowtemperature operation t 4k colloidal qds present similar lightemission properties to their epitaxial counterpart and they can tackle most of the drawbacks of the latter for example solution processing enables controlled placement of qds onchip as well as very high throughput preparation via wetchemistry approaches in addition colloidal qds have the potential for operation beyond cryogenic temperatures nonetheless stateoftheart colloidal qds with shortwave infrared emission swir 7501600 nm contain either lead or mercury which are severely restricted by the rohs indium arsenide inas qds are among the few swiremitting rohscompliant materials yet only a limited number of synthetic approaches lead to emissive qds moonshot will focus on developing highly emissive and blinkingfree inas colloidal qds based on a synthetic route employing commercially available precursors moonshot adopts a highrisk strategy to realize a new technology in the field of quantum light sources with an immediate outcome in the form of optimized singlephoton swir emitting qds
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3os and ip awareness raising for collaborative ecosystems
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zooom aims to raise awareness on the importance of ip generation and management in collaborative innovation ecosystems which rely on three key assets software hardware and data open software hardware and data are essential for a sustainable trustworthy and sovereign industrial ecosystem however lack of competences in matching business models with appropriate licensing frameworks prevents unlocking the full potential of emerging technologieszooom departs from the concept that achieving strategic autonomy and technological sovereignty is possible through a sound understanding of what open licensing strategies are the best match for specific business models this includes knowing when and to what degree it makes sense to stay open and when going proprietary is the best strategythe project aims to reach three core target groups actors in innovation ecosystems knowledge generators innovation support organizations and key stakeholders knowledge generators will benefit from tools for learning and supporting everyday development increase competences on open licensing strategies for ip management disseminate the concept and facilitate the application of ip management by identifying and suggesting viable business models enabled by open licensing strategies supporting organizations will get tools for internal training support material to empower their clients identify formats or services able to increase the reach of the ip management concepts and a database of cases analysed under the lens of open licencing and business development key stakeholders will benefit from a white book suggesting an integrated eu approach to open licensing of software hardware and data as intertwined components of the innovation policy this will set the basis for further research on the role of open licensing from a joint legal and business perspective and guide the implementation of ip management and valorization in collaborative development platforms
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contextaware verifiable dynamic deliberation
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in recent years robots are being increasingly deployed outside strictly controlled environments when faced with unexpected situations these robots are often incapable of taking appropriate action and require human intervention the goal of convince is to advance the capabilities of robots to perform complex tasks robustly and safely within unstructured environments via autonomous and unsupervised adaptation to the environment and operational contextmore specifically the key contribution is to develop cognitive deliberation capabilities that ensure safe robot operation over extended periods of time without human intervention these capabilities will be integrated into a modeldriven software toolchain to allow developers to build applicationspecific deliberation systems able to i determine robots behaviors required to fulfill a given task also taking into account the context in which the robot operates and the experience gained during previous executions of the same task ii deploy and configure the components that are required to execute these behaviors iii automate the analysis of behaviors to ensure that they are safe and secure leveraging on formal models and tools for designtime and runtime verification the toolchain shall be based on proven system modeling concepts particularly from the eufunded project robmosys major parts shall be opensourced with adapters to relevant robotics frameworks like the robot operating system rosto ensure realworld applicability convince will demonstrate the technology developed in the project on three different realworld use cases each of which presents unique technical difficulties and utilizes robotic systems of increasing complexity in different application domains vacuum cleaner robot assembly robot and robotic museum guide
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doctoral training network for quantum enhanced optical communication network security
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the security of data has never been more valuable today cryptography is critical to the safe operation of digital infrastructures however yearly advances in quantum computing present new threats quantum key distribution qkd may provide the best protection an approach designed to ensure privacy using quantum information encoded on photons in theory qkd is proven secure in practice qkd systems deviate from this theoretical behaviour due to implementation currently qkd requires a separate dark fibre due to its susceptibility to classical channel effects eg noise kerr nonlinear interference and scattering effects separating qkd from classical optical signals is costly and impractical keeping qkd a niche product therefore network providers seek quantum security to coexist in existing classical optical infrastructure a better understanding of a quantumclassical optical channel is needed to develop improved channel coding robust errorcorrecting schemes digital signal processing and optoelectronic components for the transceivers in addition a study on network topologies and integrating classical to quantum signals on implementation security is needed the doctoral research network qunest aims to gather diverse industrial and academic partners with strong scientific and technical expertise in qkd technology and optical communications to establish a new innovative multidisciplinary training network for doctoral researchers dr with the highlevel objective of training experts to design develop and drive the future quantum secure optical infrastructure forward this doctoral network will train 11 dr fellows leaning on the expertise of 17 partners 6 universities and 11 industrial partners ie 1 simulation software provider 2 telecom operators 2 smes and 6 hardware vendors from 7 european countries qunest provides a unique and timely opportunity to train students in quantum physics and optical communications
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uncovering the diversity of cellcell interactions that impact cell fates
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multicellular life relies on coordinated physical interactions and communication between cells in these interactions cells exchange information that determines their fate physiological state and behavior the substantial transcriptional heterogeneity that is evident even among cells considered the same type however raises questions about exactly which temporal and spatial interactions regulate development and homeostasis during development for instance multipotent neural crest cells migrate along different pathways in which they encounter microenvironments that are thought to instruct their migration and fate choices to ultimately reveal how cell communication shapes cell identities and cellular decisions we need to know the transcriptional state of a cell and that of its neighbors current technologies either sequence single cells at high transcriptional resolution or localize cells in their spatial context but without capturing their precise transcriptional configuration to overcome these limitations we will establish a novel approach that provides highresolution transcriptomic information on cellular microenvironments we will use this approach to uncover the interactions and communication codes that neural crest cells are exposed to along their developmental path in addition we will develop strategies to systematically identify cellcell interactions likely to determine migration and cell fate decisions and elucidate their functional role in the developing embryo our overall goal is to uncover how the diversity of cell interactions orchestrates the development of a complex cell lineage this approach and the insights obtained here will provide a foundation for studying how cells interact in other systems such as human tissues and how these interactions are altered in disease
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thz wave accelerating cavity for ultrafast science
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particle accelerators are devices of primary importance in a large range of applications such as fundamental particle physics nuclear physics light sources imaging neutron sources transmutation of nuclear waste they are also used every day for cargo inspection medical diagnostics and radiotherapy worldwide electron is the easiest particle to produce and manipulate resulting in an unequaled energy over cost ratio however there is an urgent and growing need to reduce the footprint of accelerators in order to lower their cost and environmental impact from the future highenergy colliders to the portable relativistic electron source for industrial and societal applications the radical new vision we propose will revolutionize the use of accelerators in terms of footprint beam time delivery and electron beam properties stability reproducibility monochromaticity femtosecondscale bunch duration which is today only a dream for a wide range of users we propose developing a new structure sustaining the accelerating wave pushing up the particle energy which will enable democratizing the access to femtosecondscale electron bunch for ultrafast phenomena studies this light and compact accelerator for which we propose breaking through the current technological barriers will open the way towards compact industrial accelerators with an energy gain gradient of more than 100 mevm and enlarge time access in the medical environment preclinical and clinical phase studies this new accelerating structure will be combined with a conventional femtosecondscale electron source to provide a compact layout based on a multiskill competence non linear optics high power optical source accelerators dosimetry secured by industry partners its size and weight will for example enable it to be mounted on a robotic arm to move around a patient for medical applications or material inspection for industrial applications
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europes first unified and versatile processing platform architecture in 5nm technology with proven scalability from edge to central highperformance solutions with unmatched cost and power efficiency
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videantis hannoverde is a hidden champion for processor architecture and advanced soc design our processor architecture is in automotive production in already 15m cars to date with our team of 20 specialists we are the only sme known in the eu already starting a 5nm designour truly unified processing platform is 100 programmable and handles all signal processing tasks with superior ppa performance power area compared to other solutions building upon our reputation in automotive we scale up the architecture to 100s of cores on a single 5nm die as a reference chip platform for smart sensors up to central hpcs for adasadthis will enable european oems to realise own highestperformance and custom ai socs to reduce dependencies from their us and chinese suppliers reducing cost by up to 90with the eic funding we will support the development of the reference platform and become a key driver for europes chip sovereignty and to achieve the goals of the eu chips act
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ultraenergy efficient and secure neuromorphic sensing and processing at the endpoint
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today only very light ai processing tasks are executed in ubiquitous iot endpoint devices where sensor data are generated and access to energy is usually constrained however this approach is not scalable and results in high penalties in terms of security privacy cost energy consumption and latency as data need to travel from endpoint devices to remote processing systems such as data centres inefficiencies are especially evident in energy consumptionto keep up pace with the exponentially growing amount of data eg video and allow more advanced accurate safe and timely interactions with the surrounding environment nextgeneration endpoint devices will need to run ai algorithms eg computer vision and other compute intense tasks with very low latency ie units of ms or less and energy envelops ie tens of mw or less nimbleai will harness the latest advances in microelectronics and integrated circuit technology to create an integral neuromorphic sensingprocessing solution to efficiently run accurate and diverse computer vision algorithms in resource and areaconstrained chips destined to endpoint devices biology will be a major source of inspiration in nimbleai especially with a focus to reproduce adaptivity and experienceinduced plasticity that allow biological structures to continuously become more efficient in processing dynamic visual stimulinimbleai is expected to allow significant improvements compared to stateoftheart eg commercially available neuromorphic chips and at least 100x improvement in energy efficiency and 50x shorter latency compared to stateofthepractice eg cpugpunputpus processing framebased video nimbleai will also take a holistic approach for ensuring safety and security at different architecture levels including silicon level
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cardea career acknowledgement for research managers delivering for the european area
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cardea is the roman goddess of door pivots ideal to describe our project to develop research managers rm who strengthen europes ri excellence through a diverse set of support roles and responsibilities research management as a profession is almost invisible from policy career progression and tenure opportunities across europe also there is little consistency between countries funders policymakers and individual institutionscardea will develop supports to address this inequality our consortium has enjoyed considerable success doing this for researchers already we will create a detailed datadriven 500 participants 24 countries knowledge spacedefining and characterising the problem based on this we will develop a range of solutions including a capacity maturity model to assess and improve rm activities a novel rm hub for networking and training to include a community of practice equality diversity and inclusion widening participation eu13 publicprivate partnership actions will be at the core of our research training and enhancement activitiesadditionally the mobility and networking of rm and those with responsibility for developing rms will be included to ensure the rm ecosystem grows transnationally we will learn from each other and support one another in bringing rm careers to the next level significantly these actions will provide a significant evidence base to advocate the inclusion of rm exigences in policy and we will target this proactively targeting 38 key decision making organisationsamongst the impacts of cardea will be an enduring network and hub that can facilitate rm development and collaboration a validated methodology to assess rm careers and a wellestablished baseline against which improvements can be objectively measured this allows us to develop an rm charter and offer a concordat to institutions and organisations that make significant commitments to developing rm activities in a structured mature manner
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a digital twin for geophysical extremes
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with present computational capabilities and data volumes entering the exascale era digital twins of the earth system will be able to mimic the different system components atmosphere ocean land lithosphere with unrivaled precision providing analyses forecasts and what if scenarios for natural hazards and resources from their genesis phases and across their temporal and spatial scales dtgeo aims at developing a prototype for a digital twin on geophysical extremes including earthquakes volcanoes tsunamis and anthropogenicinduced extreme events the project harnesses worldclass computational and data research infrastructures ris operational monitoring networks and leadingedge research and academia partnerships in various fields of geophysics the project will merge and assemble latest developments from other european projects and centers of excellence to deploy 12 digital twin components dtcs intended as selfcontained containerized entities embedding flagship simulation codes artificial intelligence layers large volumes of realtime data streams from and into datalakes data assimilation methodologies and overarching workflows for deployment and execution of single or coupled dtcs in centralized hpc and virtual cloud computing ris each dtc addresses specific scientific questions and circumvents technical challenges related to hazard assessment early warning forecast urgent computing or resource prospection dtcs will be verified at 13 site demonstrators sd and their outcomes will contain rich metadata to enable semiautomatic discovery contextualisation and orchestration of software services and data assets enabling its integration to the european open science cloud eosc the proposal aims at being a first step of a longterm community effort towards a twin on geophysical extremes integrated in the destination earth destine initiative
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conserved developmental trajectories channelling lateral root primordium morphogenesis
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the root system anchors the plant to the ground and absorbs water and nutrients to sustain plant development understanding root development and its adaptative behaviours to changing environments is a major goal of the 21st century this interdisciplinary project aims to identify a conserved developmental program between a nondomesticated model plant brachypodium and a cultivated legume crop lupin secondary root formations such as lateral root lr and cluster root cr are significant contributors to the adaptative nature of the root systems architecture this work will initiate five new collaborations and reciprocal expertise transfers that will benefit both the host labs and the researcher preliminary results from the hosting labs showed that brachypodium lr and lupin cr organogenesis share common developmental stages the objectives of plantid are i investigating the developmental trajectories of lr cells in brachypodium and ii identifying key cell wall cw regulators required for lrcr development in brachypodium and lupin the first phase of plantid will be conducted in the laboratory of cell and molecular biology at the university of neuchtel ch and the second phase at the ipsim institut for plant sciences of montpellier montpellier fr the two research labs have complementary experiences in the root development of those organisms secondment at mpimp laboratory in potsdam will generate the first cw atlas in lr morphogenesis for the two species i will lead this fellowship with my strong expertise in cw biology and lr development i will identify genetic regulators that impact nutrients and water uptake with a high potential for agricultural applications in cereal species eg biofuel and crop productivity the project objectives support the strategic plan for research and innovation in the horizon eu 202124 and the eu green deal restoring eus ecosystems and biodiversity to manage sustainable agriculture cluster 6
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closing the european gap towards a large scale ex vivo platelet production built upon a silkbased scaffold bioreactor
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the generation of ex vivo functional megakaryocytes mk and platelets is questioning current transfusion medicine exclusive reliance on blood donors to produce platelets the demand for platelets is in fact in continuous rise driven by an aging population advances in medical procedures and even more aggressive cancer therapies although the supply of blood donors continues to remain stagnant ex vivo platelet production systems have then emerged as a feasible supply that can moreover secure universal compatibility to avoid platelet refractoriness if during the fet open application we have proved that the platelet production ex vivo can be precisiontailored with the correct physical and biochemical environment now with silkplatelet our consortium is looking forward to demonstrating the feasibility of an upscaled ex vivo production system to bring then our technology from trl4 to trl6 we will increase the ex vivo platelet production capacity with media and stem cells aligned to gmp requirements for largescale clinical transfusion our goal is to produce universal platelets particularly for patients with immune reaction to previous transfusions with hla null platelets and patients with acute hemorrhage at the core of our from labtopatients roadmap we will find both unicam proprietary technology to differentiate stem cells into mk precursors natural source of platelets and unipv disruptive bioreactor made of a silkscaffold to mimic the bone marrow conditions these will be then complemented by igr longterm experience in ipsc and mk biology and isenet cell quality control contribute to the standardization of the platelet production pipeline and its validation and verification under the guidance of our experienced tech transfer officers by the end of the project we expect to complete the transition into a commercial innovation exploited by a next university spinout
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graphite resilience for lithiumion battery anodes through a sustainable european endtoend supply chain
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the project gr4fite3 aims to reach graphite resilience for lithiumion battery anodes through a sustainable european endtoend supply chain this supply chain includes environmentally responsible european mining of natural crystalline flake graphite from europes largest natural graphite resource highly innovative continuous and low energy input upgrading of the mined ore adding recycled and fully repaired for reuse synthetic graphite and optionally silicon nanoparticles to compose a unique anode active materials particle architecture making the high density anodes creating the cells developing battery modules certifying the lithiumion batteries for safety and viability and ultimately using these products by the oems including an established european electric bus manufacturer and a utility grid developer among others the purpose of gr4fite3 project is to demonstrate the creation of a sustainable supply chain for the european industrial graphite and carbon products for specific use as anode active materials in lithiumion batteries designed for applications in electric vehicles and power sources for utilities such as solar and wind farms this project is going to combine the efforts of 10 partner organizations from six european nations employing both industry and academia there are also four oems and five supporting organizations who have expressed their interest in tracking projects progress and parttaking in a tangible manner in commercialization efforts associated with gr4fite3 projects outcomes with this larger group of stakeholders the project spreads its reach to as many as ten countries and three continents ensuring its global outreach from the very start
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tackling the peak assignment problem in xray photoelectron spectroscopy with first principles calculations
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xray photoelectron spectroscopy xps is one of the most widely used methods of characterization in applied surface science it is applied in studies of heterogeneous catalysis environmental degradation corrosion the manufacture of surface coatings and various other processes however the practical value of xps measurements is currently negatively affected by widespread problems in the analysis of recorded spectra these have been extensively discussed in recent scientific literature and problems with peak fitting and peak assignment in core level xps have been identified as a source of significant errors in the analysis of xps spectra these problems can limit the amount of useful chemical insights that xps is able to provide and moreover incorrect peak assignments can lead to the wrong conclusions being drawn about the underlying chemistrythe aim of this research project is to tackle these problems by enabling and encouraging the more widespread use of computational methods in the interpretation of experimental xps spectra and to thereby make xps a more reliable and more useful method of characterization specifically we want to make existing computational methods for calculating core electron binding energies and simulating core level spectra accessible to a wider community of researchers and to improve these methods such that they would better meet the needs of xps users we will develop new computationally efficient and userfriendly implementations of the scf method and the gwcumulant approach carry out casestudies that are designed to test the limits of current theories in guiding the analysis of real world spectra and organize workshops and write tutorials to increase the user base of the computational techniquesthe planned work will be carried out by an international interdisciplinary and intersectoral team of experts in theoretical spectroscopy developers of electronic structure codes xps users and instrument manufacturers
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breaking frontiers in sustainable and circular biocomposites with high performance for multisector applications
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biontier offers innovative solutions to environmental challenges and establishes a holistic integrated and industrialdriven platform for the design development and scalable fabrication of the next generation of costeffective sustainable lightweight recyclable biobased composites bioc with enhanced properties eg thermal mechanical chemical functionalities eg corrosion chemical and fire resistance hardness and impact resistance high temperature resistance structural health monitoring biontier will also advance manufacturing processes enhancing synthesis and stability and reducing environmental impact such bioc and manufacturing capabilities will allow robust connections with endusers and thus develop and qualify the commercial propositions to high trls biontier will develop demonstrate and validate the efficacy of biocenabled products 6 use cases which will underlie future technologies for different sectors eg automotive aerospace energy hydrogen economy and water treatment biontier also supports the innovation output and industrialization efforts of the eu initiatives and strategies for circular bioeconomy building a credible pathway for the newly accumulated knowledge to impact eu industry and society biontier will support a strong eu value chain in translating technology advances from trl45 into concrete innovation opportunities and production capabilities trl67 with firstmover market advantages of scale in the defined industrial sectors the consortium consists of 25 partners from 12 countries representing the full value chain with leading oems large industries worldclass research and education organisations and innovative smes biontier is designed to ensure maximum impact for the defined industries and society as a whole significantly contributing to the evolving field of bioc
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optimizing stratification for trial design in alzheimers disease
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alzheimers disease ad heterogeneity is associated with distinct risk factors clinical manifestations rates of cognitive decline and comorbidities however this population variance is not properly incorporated in clinical trial design directly hampering successful development of treatments as the field is shifting towards early secondary or event primary intervention the overall objective of the current project is to optimize clinical trial design of an early ad population by providing datadriven guidelines for sample stratification and outcome measures to this end i will assess neurobiological heterogeneity in 2000 cognitively unimpaired cu and 900 mildly impaired mci subjects enrolled in the biofinder study from lund university host institution using their unique dataset i aim to identify subtypes of amyloid avascular interplay the two most common cooccurring and interacting pathologies in the aging brain next the role of neuronal function microglial activation and novel targets through proteomics analyses based on csfplasma biomarkers on disease progression within these subgroups will be determined finally resulting taupet accumulation patterns and cognitive decline across domains across will be assessed a main innovative aspect and strength of this project is the utilization of regional information available from the imaging modalities an aspect of analyses which i have specialized in in turn the expertise of the host institution regarding fluid biomarkers and taupet imaging is paramount to support this multimodal project finally our respective experience with longitudinal study design will support a critical aspect of the project which is lacking even in the most comprehensive studies to date unravelling heterogeneity in disease trajectories is paramount to optimize trial population selection and stratification directly increasing the changes of positive trial outcomes
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cryogenic storage and refuelling in space
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to move away from the dependence on hydrazine for space propulsion greener alternatives must be sought cryogenic propellant combinations such as oxygen methane offer higher specific impulses than storable combinations but their low saturation temperatures raise additional challenges with respect to preventing their evaporation during longterm storage while the ability to refuel craft with cryogenic propellants would allow for longerterm manned missions to mars and the moon as well as aid in the improvement of inspace sustainability preventing the evaporation of the propellants during the transfer process also poses challenges as of today neither longterm storage nor refuelling with cryogenic propellants has been demonstrated inorbit crysalis will develop and mature the technologies needed for the management of cryogenic propellant for future space transportation and inorbit servicing activities this maturation will include performing a smallscale inorbit demonstration to mature those whose performance can only be characterised in a microgravity environment this will be a closedsystem demonstrator flown onboard the nyx capsule which will aim to not only demonstrate the feasibility of such processes but will aim to improve the understanding of the behaviour of such propellants under microgravity allowing for development of future systems these technologies will aid in ensuring the independent access of the eu to space in particular to manned and heavy missions beyond geo and leo by supporting the development of a logistical network of craft depots and hubs required for cislunar and future martian missions
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manuscript culture in the age of print
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the prima project will redefine our understanding of how culture was produced and disseminated in early modern europe 15751800 prima will uncover the importance and the scale of manuscript production and publication for literature science music and other areas for a period when print is believed to be the dominant if not the only technology for publication by investigating the indissoluble connection between text and carrier prima will explore how manuscripts have shaped society for much longer than believed the prima project will unveil the rich manuscript culture that hides in the plain sight of scholars and answer why so many manuscripts were produced by whom for whom and how we will assess the existence of modern scriptoria uncover monastic writing practices in the modern period and focus on manuscript production within universities and academies for literature particularly satyric and lyric poetry and theatre it is our argument that manuscript dissemination is the norm and that print is exceptional we will focus particularly on italy while allowing for significant openings towards other cultures italian manuscript production and consumption are both exceptionally rich and understudied adopting qualitative and quantitative methods and innovative computational approaches for data mining production and retrieval will ensure the projects feasibility the investigation of postprint manuscripts will uncover unknown works which will help redefine our understanding of literary production for the 17th through the 18th centuries by fighting teleological prejudices about the inferiority of manuscripts with respect to print from the 16th century onwards finally prima will also investigate cases of printmanuscript hybridisation where manuscripts imitate print or include printed sections the projects main outcomes are the creation of a new discipline and a centre for modern manuscript studies a book collection and an oa
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replicable and efficient solutions for optimal management of crosssector energy
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the resonance project develops an innovative software framework that provides means for rapid development and plugandplay deployment of standardcompliant customer energy manager cem resource manager rm and their aggregation solutions the cem specified in the en 5049112 standard family is the nextgeneration demandside flexibility management dsfm solution in europe cem is a software agent that automates dsfm by interacting with smart appliances represented by rms aggregators and the markets to maximize customer benefits according to the new en 50491122 standard cems are envisioned to 1 provide a more deterministic demand response and 2 be able to optimize consumer benefits with respect to multiple incentives and optimization targets to achieve this there is a need for accurate models of flexible assets smart appliances and model predictive control techniques to automate the decisionmaking within the customer premises the resonance framework will facilitate the adoption of cems as the next generation dsfm system by significantly reducing the development efforts and costs this is achieved with 1 a standardcompliant and modular system architecture and 2 an innovative modeling pipeline that combines automated machine learning automl with physicsbased modeling to provide accurate and robust models of flexible assets with minimum effort the project brings together 19 partners including a cluster with 40 organizations with interdisciplinary expertise and forms a basis for a crosssector energy ecosystem that significantly contributes to the mobilization of dsfm at a large scale large scale piloting in six member states with a variety of consumer sectors flexible assets eg electric vehicles hvac systems and white goods stakeholders and market settings including sector integration with district heating is utilized for demonstrating and validating the scalability and replication potential of the solutions
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digitalised value management for unlocking the potential of the circular manufacturing systems with integrated digital solutions
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the aim of the current project is to bring about the development of the full demonstrator of dicim a set of integrated digital solutions that makes use of internet of things iot machine learning ml based artificial intelligence ai big data image processing and augmented reality ar to support different actors of the industrial value chain such as managers engineers and operators in their decision making and to carry out value recovery activities for circular economy the integrated digital solutions include an open access digital platform for lifecycle information management and support solutions for value recovery activitiesdicim project revolves around the value use and value recovery phases of the circular value model cvm with the specific data technology and the management needed to support its implementation in particular it focuses on integrated digital solutions to enabling condition monitoring during the use phase optimizing the reverse logistics and achieving efficiency and responsiveness in the value recovery activities ie collection inspection sorting disassembly testing and repairingrefurbishingremanufacturingrecycling to enable reuse of products parts and materialsdicim project will demonstrate integrated digital solutions in four use cases in three industrial sectors that represent over two thirds of the european economy they include whitegoods ie refrigerators washing machines electronics ie printers and automotive with important gains such as increase in spare part recovery efficiency by 90 which means 126 000 labour hours are saved for refrigerator demonstrator and increase in spare part recovery rate by 20 about 2920 tons net material saving for washing machines and 6000 tons for automotivedicim digital solutions will boost new circular economy business models based on value recovery activities to sustain and encourage remanufacturing throughout europe
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solutions to prevent and mitigate the impacts of habs in aquaculture and fisheries in the context of global warming
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harmful algal blooms habs are considered a threat to the environment and to human health major concerns are addressed to the increasing occurrence of these natural events in certain regions of the world driven by global warming and anthropogenic pressure human illnesses related to the intake of contaminated seafood have been attributed to these events furthermore habs have a significant impact in economic activities such as aquaculture and fisheries the occurrence of habs in natural areas utilized for aquaculture or harvestingfishing can affect species growth and nutritional parameters or even cause mass mortalities causing huge losses in the industry the regulation of toxin levels in seafood and other measures eg forced closures to seafood harvest during the occurrence of habs have been contributing to protecting humans from serious intoxications on the other hand the impacts on the industry lack mitigation measuresthis project aims to contribute to the development of solutions for the aquaculture and fisheries sector through the development of efficient methods for the detection of habs early warning and the development of farming and depuration systems for shellfish to reduce the toxin load the project also aims to advance in the understanding of regulated and emerging toxins chemical and toxicological evaluation and their global expansion and toxin incidence and persistence in seafood traditional and nontraditional vectors species not yet investigatedfor the implementation of the project an interdisciplinary consortium was built which brings together specialists from different areas of knowledge and who will develop joint research and innovation activities which collectively will contribute to the technological innovation of the aquaculture and fisheries and sustainable growth of this sector and to environmental monitoring
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green horizon on organic semiconductor technologies
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the green deal has made it necessary to develop low power electronics using sustainable materials and green processing the successful implementation of amoled active matrix organic light emitting diodes displays in mobile phones organicbased electronics illustrates that the green deal is possible however current organic electronics technologies have yet to be efficiency and not all are produced via low embedded energy processing methods by using bio inspired organic materials deposited by green process technologies achieving these goals could be realised during project ghost we will focus on inter molecular interactions to help address these issues irrespective of application amoled organic photovoltaics opv organic fieldeffect transistors ofet or organic thermoelectric generators otg the active materials are used in a solid matrix that stabilises them but also changes their properties relative to those in solution there are many examples where guesthost interactions eg donoracceptor materials in opv devices completely change the properties of the system using lightemitting guests blended in a host or donoracceptor exciplex systems leads to increasing oled emission efficiency but how to control these interactions is not well understood and is still largely emipirical interactions can change both the molecule conformation and electrooptic properties of the materials but theoretical approaches to understanding these mechanisms are still in their infancy moreover the varried effects of such intermolecular interactions in working devices is very poorly understood currently our limited understanding of these phenomena limit our ability to develop bio inspired materials and active components all life on earth is organic and can perform complex of functions taking inspiration from living organisims we aim to develop a new low energy organic electronics technologies
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pzt and graphene materials innovations for advanced optoelectronic applications in ar and biosensing
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europes leading position in photonics and electronics can only be secured by adapting to the next generation of optoelectronic devices requirements high performance multifunctionality and cost efficiency in miniaturized footprint these can only be achieved if novel schemes for onchip integration emerge among the established platforms for optoelectronic integrated circuits oeics silicon nitride as a wideband and lowloss material stands outs however si3n4 itself has no active effect and the heterogeneous integration of active iiiv and iivi semiconductor chips is currently very complicated and costly matel offers a unique solution to this challenge and promises to enable a novel onchip integration scheme laser digital processing laser transfer and laser soldering will be employed for the accurate and fast alignment and bonding of any type of chip package oeic on si3n4 the hybrid platform will be enhanced bythe monolithic integration of advanced materials graphene and highquality pzt which will enable multiple functionalities in miniaturized footprint matel will thus demonstrate two nextgen optoelectronic devices at trl51 2d light source for ar displays with integrated rgb lasers and oeicbased demultiplexers2 biophotonic sensor for antibodies detection with onchip vcsel at 850 nm featuring graphene photodetectorsoverall matel s hybrid platform will combine the wide bandwidth and high confinement provided by si3n4 with the active functionality of iiiv and iivi lasers supporting a broad spectrum of nextgen applications extending far beyond these demo applications hence matel will reinforce the existing collaborations within the consortium and introduce new ecosystems estimated to strengthen the eu photonics and microelectronics industrial capability by generating multi m turnovers to the involved smes and more than 200 new employment positions by the end of its timeframe
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navigating the marketplace of indicators
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most policy fields in global governance have an abundance of country performance indicators cpis and new cpis proliferate apace states are now measured and ranked on a dizzying array of crosscutting metrics prima facie the era of indicators promises a revolution armed with ever improving data policymakers can better allocate scarce resources to address global challenges yet the era of indicators generates a problem and a paradox while each individual cpi strives to simplify complexity an abundance of cpis on the same issue multiplies complexity and thus generates ambiguity moreover while it would be reassuring if we could assume only the soundest cpis would thrive many highprofile cpis remain in widespread use despite wellknown shortcomingscrucially the paradox begets a major puzzle that prior research has yet to consider how do private and public bodies navigate policy fields populated with multiple indicators each portending to measure the same phenomenon although prior research provides firm grounds to hope that cpi users and producers improve their practices over time no studies have investigated whether they do rendering this gap tractable navigator investigates the marketplace of indicators in four major policy fields education global governance climate policy and pandemic preparedness navigators novel frameworkinspired by the classic liberal theory of the marketplace of ideasenables the systemic longitudinal analysis of how users and producers adapt their practices over time whether users learn in light of criticism of their favoured cpis how they discern when faced with a diversity of cpis and how producers compete for users within crowded policy fields in this way navigator would push the frontier of cpi research by conducting a systematic problem shift from investigating a single cpis influence or limitations to examining how users and producers adapt in the face of growing cpi competition and cpi critique
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accurate computational tools for biomolecular vibrational spectroscopy actbio
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vibrational spectroscopy has evolved into many branches and proved to be increasingly efficient in studies of biomolecules and their functions in living organisms to further increase its potential in this project we will develop and apply userfriendly tools actbio for simulation of the spectra beyond the harmonic level we will focus on vibrational optical activity voa because this spectroscopy reveals unique information about chiral molecules thanks to the recent instrumental developments in the hosting institute nonfundamental bands can be captured with a high precision and the simulation methods for these complex bands will help us to understand many molecular propertiesthe project tightly combines both experiment and the theory based worldrecognized expertise in this field of the hosting institute and secondment laboratories i will receive experimental training further develop the extended perturbational approach to deal with the challenges of complicated biomolecular systems such as large amplitude motions and solvent effects in polar and flexible molecules melanocyteinhibiting factor is selected as a testing system for the developed computational models and protocols in summary actbio will deliver accurate theoretical basis for spectroscopic biomolecular studies and will provide us with knowledge of molecular behavior needed for applications in chemistry medicine and biology
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many paths to separate sexes the genomics of sexdetermination in the hawaiian wikstroemia
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life on earth has undergone several major evolutionary transitions but perhaps none so striking or relevant to our daily lives as the origin of separate sexes yet despite intense study for over 100 years understanding how and why genes determining sex evolve and the consequences for the chromosomes harboring them remains an open problem in evolutionary biology one obstacle is that most previous work has focused on ancient sex chromosome systems like those found in mammals where recombination suppression and genetic degeneration has obliterated any signs or signals of how genetic sexdetermination evolved in the first place but here flowering plants angiosperms come to the rescue compared to animals angiosperms exhibit a staggering diversity of reproductive forms and have transitioned from combined hermaphroditism to separate sexes dioecy many times in their evolutionary history the goal of this project is to understand the genomic changes giving rise to at least two and possibly three parallel transitions from hermaphroditism to dioecy via the evolution of new sex chromosomes within an endemic hawaiian radiation of the flowering plant genus wikstroemia thymelaeaceae 12 spp using a combination of genomics bioinformatics gene expression and greenhouse experiments i aim to achieve three key objectives 1 locate and fully annotate sexlinked regions of the genome associated with each form of dioecy 2 clarify the systematics of this radiation and study the biogeography of sexlinked genes and the relative times of origin and whetherhow recombination suppression has evolved for each form and 3 determine what genesdevelopmental pathways are involved in sexdetermination in these closely related lineages this fascinating radiation offers a unique snapshot of repeated evolution of genetic sexdetermination from a common genetic starting point shedding new light on how and why evolutionary transitions to separate sexes occur
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fast matrix multiplication for ai
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matrix multiplication consumes huge amount of resources computing time and energy primarily in ai applications the industry has recognized the need for faster and more energyefficient matrix multiplication with stateoftheart solutions in software eg dgemm of intels math kernel library mkl for cpu and nvidias cuda for gpu and hardware eg googles tpu and intel habana labs gaudi accelerator unfortunately all present solutions employ a wasteful cubictime algorithm we have developed methods that provide speedup for matrix multiplication in sw and in hw the novel developments of prof oded schwartz and his strong team are based on years of research and are protected by several patents the funds are requested to pursue business opportunity
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polymofs as promising drug delivery systems for antimicrobial therapy
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the combination of metal organic frameworks mofs and polymers is highly desirable since both contribute with outstanding features high and defined porosity and crystallinity as well as tunable mechanical and chemical properties respectively in particular they represent an appealing strategy in the field of drug delivery systems dds i the polymer can increase the chemical and colloidal stability of the dds ii the polymer can present itself biological activity eg antimicrobial and stimuli response eg ph temperature iii the metal centers of the mofs can exhibit intrinsic bioactivity eg zn2 cu2 fe3 and iv the mof porosity can adsorb and progressively release exceptional cargoes of complementary active ingredients mostly associated as composite or coreshell the coordination of the polymer as a building block to the metallic part of the mof polymof is almost unexplored until now only 10 polymofs over 90000 mofs have been reported and all of them being in the exploratory phase with no demonstrated potential applications in this sense highly robust polymofs will be here prepared based on polymerscontaining polycomplexant ligands instead of molecular polydentate ligands and bioactive cations stablishing a platform for the development of a library of polymofs with innovative combined antimicrobial properties as proof of concept the in vitro safety and potential activity of these novel polymofs will be evaluated for the challenging antimicrobial therapy finally the scaleup and potential technology transfer of the most promising prototypes will be assessed within an industrial placement at immaterial ltd
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reproductive health under algorithm surveillance
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fertility data can be misused to increase womens inequalities affect their reproductive autonomy and violate their rights thelma will explore such impacts on womens rights due to algorithm surveillance in reproductive health by femtechs the tech industry focused on womens health and wellbeing which can provide statistical analyses enough to control fertility on a mass level several concerns about this industry have been reported in scientific studies gender biases enforcement of gender binary stereotypes sharing users data with third parties without consent data collection for profit and advertising unwanted pregnancies etc however the invisible power relations that drive the use of fertility data with multilevel effects on womens rights due to their social economic and political body value in producing human capital have not been explored until now thelma will provide critical analyses about this industry producing datadriven analysis and insights that will contribute to developing an eu regulatory framework for femtechs based on interdisciplinary intersectional and gendersensitive approaches combining social science methods with legal analyses thelma will be carried out in the gender and ict research group gentic from the internet interdisciplinary institute in3 at universitat oberta de catalunya uoc spain focused on gender studies in the digital age the research findings will contribute to enriching the current stateofart on fertility data and digital surveillance in the eu with enduser experiences as focal points success in my multidimensional training with my host will position me as an intranational expert combining quantitative research and legal theoretical expertise that will contribute to innovative eu research on fertility data
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signatures of cosmic rays and new fundamental particles in the very high energy sky
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are there new fundamental particles and interactions beyond the standard model of particle physics bsmthe most fascinating open questions in our current understanding of nature support a positive answer for example the dark matter in our universe could be explained by new fundamental particles weakly coupled to the sm similarly the unexplained chargeparity symmetry violation in strong interactions can be solved by introducing a new light particle the axion some recent intriguing anomalies in cosmic radiation have thrilled the community as potential evidence for new physics bsmmy project will shed new light on them by exploiting forthcoming observations of the very high energy sky with innovative techniques a longstanding excess of gammarays at gev energies is measured towards the galactic center gce and could be the very first signature of particle dark matter in our galaxy cosmic ray accelerators could also explain the signal but numerous modeling uncertainties prevent to firmly assess their contribution to the excess i will use gamma rays at tev energies to robustly characterise the tev halos of cosmic ray accelerators and their contribution to the gce thus closing on the dark matter properties compatible with itbesides these sources will serve as an unique laboratory to constrain cosmic ray acceleration and propagation in the interstellar medium this work will be instrumental to deeply investigate a new promising signatures of photonaxion interactions that is the modulation of the gammaray spectrum of galactic cosmic ray accelerators by exploiting the unprecedented energy resolution of forthcoming gammaray data at very high energy i will search for axionlikeparticle signatures in a yet unexplored parameter space at lapth i will have access to the crucial expertise needed to successfully carry out the designed project which will strategically complement my current research profile to flourish as a senior researcher
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smart digitalized components and systems for databased agriculture and forestry
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food security is a global challenge and is impacted by rapidly compounding effects including climate change supply chains human labour shortages driving the need for traceability and technological innovation and automation to name a few the latest important price increases of agricultural row products show the limitations of the available resourcesthrough this joint undertaking the agrarsense consortium of 57 partners including 4 affiliates plan to take agricultural technology and productivity to the next level beyond the stateoftheart by combining some of the most advanced organisational capabilities from across european industrial 16 large enterprises 25 smes and 16 research technology organisations rtos from 15 countries the development of the most advanced sensory and autonomous agricultural capabilities requires a sophisticated governance structure ensuring that all partners are aligned across use cases and work package deliveries the agrarsense consortium has one of the worlds leaders in forestry automation komatsu as project coordinator the agrarsense project goal of creating a holistic ecosystem of sensory and automated capabilities will further extend europes lead in optimizing and securing agricultural value chains to drive such an ambitious impact agenda we have selected seven use cases which will collectively contribute to solving the challenges outlined these use cases are greenhouses uc1 vertical farming uc2 precision viticulture uc3 agri robotics uc4 autoforest uc5 organic soils fertilizers uc6 and water uc7 these use cases are fused together by the most advanced hardware software and system integration technologies which will drive new solutions for partners and the collective agrarsense impacts at scale
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smart photonic devices using novel metamaterials
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alcyon photonics founded in 2018 as a spinoff of the national research council in spain provides high performance components to foster a new generation of smarter photonic circuits and devices for use in application areas like communications sensing artificial intelligence augmented reality the internet of things iot and quantum computing the sphun project will develop a digital platform with the objective to enrich and validate an extended library of innovative photonic building blocks based on novel metamaterials based on subwavelength structures enabling designers of new photonic devices to streamline their design of advanced photonic integrated circuits pics the library will offer a diverse range of functionalities with improved performance versatility robustness and lower costs than alternatives in the market today all in a simple format and compatible with semiconductor foundries traditional electronics fabrication methods
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breakthrough european technologies yielding construction sovereignty diversity efficiency of resources
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demographic trends in europe are posing a challenge to the construction sector which is facing labour shortage and an aging existing workforce this can be addressed through the integrated adoption of breakthrough technologies eg autonomous vehicles collaborative robotics additive manufacturing smart wearables digital twin and artificial intelligence which can help to get construction tasks done with more efficacy while at the same time making the sector more attractive to young people and improving the safety productivity quality and environmental impact of construction projects beeyonders will take a leap forward in the design development and integration of these breakthrough technologies in real construction scenarios bringing together the capabilities of european stakeholders thus also demonstrating how the dependency on technology import from outside europe can be reduced solutions will be developed for supporting the integration of autonomous and teleoperated ground and aerial robotic platforms and heavy equipment in harsh environments innovative additive manufacturing solutions will be developed for resource optimization and for protection of biodiversity in maritime works safety wellbeing and training of workers will be improved through the development of exoskeletons advanced wearables and learning resources supported by xr technologies a digital twin enriched with aibased layers for decisionmaking will support seamless integration and management of all project technologies these will be tested and validated in 6 demonstration case studies covering different project typologies tunnels earthworks for road construction buildings maritime infrastructures and road maintenance beeyonders impact will be evaluated both from the point of view of users acceptance eg benefits for aging workforce attraction of young workers contribution to gender balance in construction and environmenteglcalcc applied to all project
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creativity in virtual reality
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recent global developments have significantly accelerated the redefinition of organizational spaces an increasing number of organizations particularly those in knowledgeintensive areas have embraced work models partly localized away from the physical premises of the organization this is primarily driven by digitalization pandemic experiences and increased demands for flexibility from the workforce indicating a decoupling from fixed physical premises a permanent feature of the future working environment this leads to a redefinition of organizational space as encompassing spaces beyond the physical boundaries of the organization a core characteristic of this redefinition is the increased adoption of digital immersive technologies virtual reality vr solutions as additions to or even replacements of physical workspaces have accrued increased interest evident in the rising investments of the last years while companies start to adopt these technologies there is little knowledge available on the impact of the use of these technologies on work outcomes
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training the next generation of researchers that will bring rehab robots to clinical practice
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injuries and diseases affecting the nervous system pose significant challenges for patients and impose substantial socioeconomic burdens digital technologies such as artificial intelligence ai and robotics hold great promise in revolutionizing recovery processes owing to their robustness adaptability and ability to assimilate diverse patient information despite this potential current evidence suggests that these technologies have not fully met expectations we propose two primary reasons for this discrepancy 1 the absence of robotbased therapy in established clinical guidelines that therapists follow systematically and 2 the suboptimal implementation of crucial features in therapeutic interventionsspecifically tasks should be tailored intensive optimally challenging allow movement variability and foster high patient engagement in essence interventions should be personalized to each patients unique condition and requirementstailor aims to bridge this gap by offering invaluable insights and knowledge to the next generation of researchers this knowledge will empower them to comprehend the core principles of robotic technology leading to the development of highly personalized therapies that deliver longterm functional effects and significantly enhance treatment outcomes this shift is pivotal for the widespread and definitive integration of robotics into rehabilitation practicestailor represents a unique system for collecting comprehensive data on the therapy process and using ai methods to extract knowledge and to design controllers for automated therapy we expect that these aidriven controllers will enable rehabilitation to be tailored to a neuromotor status of a specific patient to a degree not possible before automatically adjusting to all the aforementioned factors the result will be a more efficient comfortable and optimally challenging therapy which will allow a boost to the functional recovery of these patients
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colonialism and translation in travel writing depicting otherness
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given colonial and imperial backgrounds on the history of many of the european powers different geographical displacements and the lack of proper representation the black community and people of colour poc are historically portrayed in a sarcastic humorous and racist fashion in european textual and visual repertoire one would assume that the traditions perpetuated by colonial powers in representation of otherness would be replicated in imperialist countries but these attributes can also be seen in countries that have no slavery or colonial past depictness is an interdisciplinary postdoctoral project that lays in the inbetween place of translation studies and semiotic studies not to mention other relevant fields as travel writing and comparative literature one of depictness objectives is to analyse the works of herg belgian cartoonist and gori estonian caricaturist chosen images of both artists poc characters will form the visual selection while the phrases using petit ngre in the herg collection and its translations in portuguese galician english and estonian will form the textual selection both selections will be analysed and compared to see how differently white and poc characters are portrayed textually and visually by both artists for the visual selection a semiotics approach will be used while for the verbal selection a postcolonial methodology applied to translation studies will analyse the implications of being described by an accent concerning this selection and the artists production founded on travel writing theory another objective of depictness is to coin a travel writer category called the static traveller taking in consideration the analytical corpus of the project the multicomparative approach of depictness plot imagery and textual selection in order to explore the representations made by gori and herg
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neolithic coastal settlements and responses to environmental dynamics a pioneering world lost beneath the mediterranean sea
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coastal societies hold a vital place in mediterranean history many of their earliest trajectories however are archaeologically obscure due to a rise in sea levels since the last ice age beforetheflood is based on an observation that before it was inundated the mediterranean littoral was extremely dynamic eg formationretreat of marshes increased soil salinity rapidly rising sea levels necessitating constant reactions by its inhabitants this project aims to study how neolithic coastal societies in the eastern mediterranean pioneered cultural responses to environmental changes and how these enabled the development of mediterranean complex societies the earliest known mediterranean coastal settlements and their paleolandscapes now situated offshore along the carmel coast israel will be studied by drilling sediment cores and through underwater excavations followed by microscopic and chemical analysis in the laboratory that will integrate geoarchaeology bioarchaeology and paleoenvironmental reconstructions the projects novelty lies in its approach which will generate a highresolution diachronic model of how hyperlocalised environmental dynamics are directly related to archaeological evidence of adaptive solutions the project will test how neolithic coastal communities constantly readapted to dynamic environmental processes over time by modifying their environment and developing new technologies and social interactions ie negotiations with inland farmers that fostered the establishment of a unique mediterranean coastal society beforetheflood will elucidate an important and asyet unread chapter of a world now lost beneath the sea one that will help to rewrite the early story of the eastern mediterranean coast as the springboard for innovation adaptation and connectivity that set the scene for the development of later mediterranean complex societies
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europes rail flagship project 6 delivering innovative rail services to revitalise capillary lines and regional rail services
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regional railway lines with lower usage or secondary network plays a crucial role not only in serving european regions but also as feeders for passenger and freight traffic for the maincore network therefore they have an essential function as an environmentally friendly mode of transport in addition is as well essential their link to other public transport services eg bus and to first and last mile services such as bikesharing cycling walking or driving to get fromto stations to remote locations unfortunately many of these routes were abandoned in the past mainly due to high costs therefore these rail lines need to be revitalized or even renewed to make them economically socially and environmentally sustainable and to meet current customer needs and challengesthe overall objectives of the future project are to ensure the longterm viability of the regional railway by reducing the total cost of ownership tco while ensuring high service quality and operational reliability it also aims to increase customer satisfaction and to make rail an attractive and preferred mode of transport therefore the main objectives of future are lowering capex system costs increasing productivity by lowering opex unit costs per train kilometre and improving customer satisfactionthese goals are to be achieved through a concept tailored to regional railways but transferable across europe encompassing digitalisation automation and the use of common and new technologies for signalling and track components rolling stock and customer information cost drivers such as infrastructure and energy components eg trackside train detection axle counters etc and level crossing control systems will be replaced by less costly wireless and energyautonomous components in addition a modular and standardised vehicle concept specifically tailored to the requirements of regional lines becomes needed as well as a range of attractive services
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implemented synergies data sharing contracts and goals between transport modes and air tansportation
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signair will develop and pilot a new platform for an orchestrated sharing of data in multimodal traveling the platform will provide the means for transport service providers tsps to register reach data sharing agreements with other tsps and manage their contractual relationships while the signair platform will only manage the contractual aspects through the types of data offered by the tsps the tsps will continue managing their data and that of their customers as an added value the signair platform will provide a number of advantages and services to the stakeholders of multimodal travel for the b2b2c chain through the analysis and exploitation of the contracts i templates for contracts to simplify the legal management ii electronic management and information provision about each specific contract iii routing information for travel companions tcs with enriched information about the specific contracts for their traveler customers and iv facilitation of single ticketing through the comprehensive understanding of the contracts and the data managed among othersthe whole concept will be moved from trl2 reached by the mother project synair to trl 7 this will be done with an intensive evolution of the software and a continuous evaluation and piloting of the software with different important stakeholders that are present in the consortium the development of the software will generate a minimum valuable product in the first 12 months of the project and in parallel it will be piloted and improved through continuous development of the technologies in the following 21 months reaching a trl7 platform in month 33 of the projectthe partnership is formed by knowledgeable teams in the areas of it legal and mobility including airports tsps and transport authorities on the piloting side
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combining artificial intelligence and smart sensing toward better management and improved quality of life in chronic obstructive pulmonary disease
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chronic obstructive pulmonary disease copd is a highly prevalent chronic condition while copd is a lung disease it is mainly the exacerbations and extrapulmonary comorbidities which affect the quality of life health care costs and prognosis the optimal copd treatment needs to focus on both the characteristics and consequences of the lung disease itself and the diagnosis and treatment of comorbidities while the severity of lung function impairment is routinely assessed the exacerbations the associated comorbidities and limitations in daily life are still significantly underestimated a personalized approach to copd management is needed to specifically address the disease prevent exacerbations and mitigate its comorbidities to obtain a positive impact on patient health and quality of life tolife will clinically validate an artificial intelligence ai solution to process daily life patient data captured by unobtrusive sensors to enable optimised personalised treatment assessment of health outcomes and improved quality of life in copd patients the tolife approach to copd management targeted to predict and mitigate exacerbations and continuously assess the health outcomes has the potential to reduce mortality improve health related quality of life and reduce the healthcare coststolife will develop and clinically validate an aibased platform for the early prediction of exacerbations and assessment of the health outcomes prediction of exacerbations and assessment of health outcomes will be exploited by clinicians through a patient management tool to perform early and personalized treatment tolife platform will inform through a disease information tool the patient and caregivers about the patients health status the specific treatment plan and lifestyle indications two clinical studies will be implemented one to collect data for aitools development and the other to validate the effectiveness of tolife to reduce the risk of exacerbations
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towards an artificial cognitive science
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with the advent of capable artificial agents comes the urgency to improve our understanding of how they learn reason and decide this proposal aims to shape a new field of artificial cognitive science in which tools from cognitive psychology are used to understand and improve the behavior of the notoriously opaque artificial agents to which we increasingly delegate autonomy and authority we will focus on the newlyemerged disruptive and increasingly powerful foundation models huge neural networks with billion of parameters that are trained on hundreds of billions of words and study them using tools from cognitive psychology we will subject these models to experimental paradigms from the psychological literature and analyze their trialbytrial behavior using detailed computational modeling psychological paradigms have been engineered to uncover precisely the mechanisms that underpin behavior we will use cognitive psychology to study and improve prompt engineering ie the design of textual inputs to these models that lead to a desired behavior afterward we will build large cognitive benchmarks to assess foundation models learning decisionmaking and reasoning abilities in both the pure language and the combined language and vision domains finally we will attempt to improve these models behavior using cognitive therapy this proposal will help to create transparent and humanlike agents and define an innovative and interdisciplinary research field in which cognitive psychologists and artificial intelligence researchers jointly examine and improve intelligent systems
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biophysical investigation of the liquidliquid phase separation solvent interface
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liquidliquid phase separation llps is central to compartmentalisation of biochemical processes and allows colocalisation of a whole biological machine and its substrates at high local concentrations this often dynamic and reversible assembly is formed by multivalent interactions between several biomolecules and some instances involve low complexity sequences that have been linked to amyloid fibre formation while the biophysical understanding of this phenomenon has recently been of high interest in the scientific community the interactions of llpsforming proteins from the dilute phase with the interface to the condensed phase remain elusive in this project we aim to dissect these transient interactions using stateoftheart biophysical techniques more specifically we will use nuclear magnetic resonance nmr highresolutionrelaxometry hrr and an array of singlemolecule fluorescence techniques to dissect up to atomic resolution and at multiple timescales the transient interactions of the dilute phase proteins with the interface of the condensed state we shall rely on the nonhomologous end joining nhej system that our laboratory has recently shown to exhibit llps in a broad range of conditions atomiclevel dynamic information on the mechanisms for nhej phase separation and assembly could prove crucial both in the fundamental understanding of llps formation and growth and in rational drug design aimed at preventing doublestrand break repair by nhej in the frame of cancer treatment
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biodiversity and trade mitigating the impacts of nonfood biomass global supply chains
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despite its importance biodiversity is at a high risk of a 6th mass extinction widespread trade networks spanning our globe allow consumption in one part of the world to cause biodiversity impacts elsewhere unfortunately we have limited and incomplete tools for assessing the impacts of trade on biodiversity which hampers mitigating these losses for policymakers retailers and other stakeholders in bamboo we want to rectify this situation with a focus on nonfood biomass we will develop models to quantify biodiversity impacts using four indicators species richness mean species abundance functional diversity and ecosystem services we will use lcimpact and globio for impact categories that already exist but update them to the newest state more importantly we will complement them with novel impact categories to cover impacts across the terrestrial freshwater and marine realmswe will create a new hybrid multiregional inputoutput mrio model based on the wellknown exiobase and the biomassspecific fabio models this mrio model will be linked to our impact assessment methods and the integrated assessment model image for scenario generation to assess global trade and identify potential leverage points for halting and reversing biodiversity loss now and under future scenarios apart from global assessments and recommendations we will test our models on two local case studies fishmeal production in peru and cotton production in tanzaniato maximize our outreach we plan to develop an online tool that will allow stakeholders to use all models easily in general our models will be freely available on zenodooverall bamboo will provide comprehensive and detailed knowledge of the effects of biomass trade from land and sea on biodiversity and ecosystem services and an improved way of identifying leverage points this will ultimately contribute to better environmental decisionmaking supporting to reach sciencebased targets and the sdgs
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the oater develops a compact machine for hyperlocal fresh oat milk production to reduce waste and emissions
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the oater is a femalefounded food tech startup from germany that develops a compact machine for hyperlocal fresh oat milk production to reduce waste and emissions the founding team cothe oater is a femalefounded food tech startup from germany that develops a compact machine for hyperlocal fresh oat milk production to reduce waste and emissions the founding team consists of four members led by ceo and head of hardware sarah nesti with lisa nesti cmo and henrik burger cfo in the business team and benjamin auer cto as the process engineer this diverse team is perfectly equipped to create a successful business the founders gained prior startup experience in a b2b ecommerce business launched in 2020 with over 30 customers and 30k euro revenue the entire team consists of 9 members including two marketing experts two business assistants and a product designerthe oaters goal is to inspires sustainable consumption to protect and enrich life for all generations to come we want to achieve this by downsizing the industrial production into a compact machine for local production of fresh oat milk this doesnt only improve taste but also lowers costs and reduces the environmental impact by producing the oat milk at the point of sale packaging is eliminated and transport emissions are significantly reduced due to the fact that oat milk is 90 water the oaters business model is oat milk as a service meaning that b2b customers borrow the machine for free and only pay by liter for the oater packages which consist of the ingredients needed to produce the oat milk in the machine this model ensures constant delivery profits and scaleup as hardware profits are negligible compared to delivery service the oater provides a holistic ecosystem solution consisting of the iot machine frequent replenishments and a smart online platform the main objectives are to introduce customers into our ecosystem simplify entry and make oat milk exciting at the pos
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formmeaning mappings in language
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mapping linguistic forms such as the word cat to their corresponding meanings such as the concept of a cat is a fundamental property of language in an ideal scenario this mapping occurs on a onetoone basis where each form uniquely corresponds to a specific meaning and vice versa however there are instances where this neat onetoone relationship breaks down and a single form takes on multiple meanings this intriguing phenomenon is the primary focus of the fomeproject the central objective of the fomeproject is to delve into how native speakers articulate their thoughts desires regrets and other cognitive nuances through clausal complementation specifically the project aims to explore the intricate ways in which individuals indicate the extent to which their statements contain familiar or new information established facts or conjectures this exploration will be grounded in two key approaches a insights derived from studying microvariation in modern greek dialects and macrovariation across diverse languages and b utilization of an array of methodological tools encompassing fieldwork experimental research involving questionnaires statistical analyses and selfpaced reading tasks examination of diachronic syntax and engagement with theoretical linguistics through this comprehensive investigation the fomeproject seeks to illuminate critical questions these questions encompass the intercomparability of different languages the boundaries of human perception and cognition that can be encoded within grammatical structures and the intricate pathways through which these aspects gradually evolve into grammatical forms
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targeted immunocytokines by caging and local release
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immune therapies have caused a paradigm shift in the treatment of melanoma and leukemias however the broad immune therapies have caused a paradigm shift in the treatment of melanoma and leukemias however the broad application of these immune therapies to all cancers has not worked one of the major reason for this failure is the presence of innate immune suppressive cell types in many tumour types such as macrophages nk dendritic and myeloid cells tumour selective reactivation of these cells is considered one of the holy grails for the future of immune therapy most endeavours in achieving this are severely hampered by the toxicity of innate immune activators they cause strong offsiteontarget systemic immune activation which can lead sepsislike symptoms and death developing innate immune activating therapies that are both powerful and safe are therefore key to applying immune therapies across the cancer landscape as part of my erccoggrant i have developed innnate immune activators that are chemically blocked but that can be reactivated locally to offer this approach can potentially serve as exactly the safe and potent innate activator required by targeting the innate activators to the tumour and only activating them once they have accumulated there we can decouple the therapeutic activity from the systemic toxicity that plagues these approaches in this proposal we aim to evaluate the first such a caged innate immune activator in a preclinical cancer model we will validate its potency pharmacokinetics and cagingdecaging behaviour in addition we will broaden the scope of the innate activators antibodies and uncaging chemistries that can be applied we will also perform market research to determine the optimal tumourimmune activatorantibody combination to take forward into clinical development and begin to take the necessary steps to spin out a company based on this work to bring these nontoxic innate activators to the clinic
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polyphonic philosophy logic in the long twelfth century c 10701220 for a new horizon in the history of philosophy
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this project aims at an innovative interdisciplinary approach to latin logical commentaries from the long twelfthcentury c 10701220 my contention is that this littleexplored topic presents us with a unique polyphonic philosophy that can open up a new horizon in our understanding of philosophical commentaries on the one hand and help to reshape some core ideas in the history of philosophy on the other at a time when both are urgently needed a team of four postdoctoral researchers led by the pi will actualise the potential of some extraordinary preliminary material to study a wealth of 12thcentury manuscripts of mainly unpublished texts with novel concepts we will have three objectives 1 a comprehensive study of 12thcentury logical manuscripts as the main units for accessing this complex field in which the notions of unitary text and author have proven challenging 2 a study of mainly unpublished logical texts from a polyphonic perspective that will follow a comparative archaeological and analytical approach and develop some pioneering digital scholarly editions of texts to model their polyphony 3 metaanalysis of the concepts used from an interdisciplinary and historiographical perspective offering new insights into the key concepts of the project and nonsolo paradigms to reconstruct philosophys past the project will require interdisciplinary expertise in digital medieval studies digital textual criticism codicology the history of education the history of literacy the social history of logic the history of philosophy and the historiography of philosophy following a concretetoabstract highly integrated research design taking advantage of recent methodologies this project has the ambitious goal of opening up an entirely new horizon for the history of philosophy while also impacting on several other areas from medieval studies to the history of universities to the study of commentaries more generally
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investigating energyenvironmenteconomic growth linkage for sustainability in subsaharan africa
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energy consumption environment and economic growth target variables exist simultaneously and are inseparable this means energy access is essential to spurring economic growth and reducing poverty however it adversely affects the environment besides there is a negative relationship between environmental degradation and economic growth thus this tension between improving energy access for economic growth and mitigating environmental externality from growth introduced a threeway link model and their interaction impact on sustainable development is the recent research agenda however previous findings examined either one or twoway links supply side demand side or environmental side theories to explore the relationship between the variables most findings overlooked the interaction impact on sustainable development and did not measured the variables in broad or specific indicators resulting in a gap in the literature knowledge furthermore the forward and feedback relationships between economic activities and the environment have not been examined therefore this study will investigate target variables linkage and their interaction impacts on the sustainable development of subsaharan african countries from 2001 to 2023 the study will employ multicountry secondary panel data analysis collected from international institutions databases it will analyze the descriptive statistics and basic panel data econometric tests and adopt the abovementioned theories capital approach and integrated sustainable development goals isdg framework and employ robust methodology like the simultaneous equation model it will provide insights into the complex relationship between target variables inform policymakers on sustainable development strategies and serve as a basis for further studies the project will also encourage investment in renewable energy and conservation the fellowship will enhance research skills visibility networking and vu capacity
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lightresponsive microalgal living materials
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nature fabricates materials with remarkable properties having the ability to grow move and sense their environment such dynamic and interactive materials are in strong contrast with manmade synthetic materials recent scientific interest has emerged to incorporate living cells into materials to form living materials using most often muscle cells or bacteria while underexplored microalgaebased living materials are highly promising due to the lightdriven movement of microalgae the aim of this erc project is to develop the first microalgaebased photosynthetic living material with a dynamically lightcontrollable shape and with locally tuned mechanical properties the fabrication of lightresponsive microalgal living materials will be possible through novel fundamental knowledge that we will gain regarding the growth and motion of microalgae within a porous hydrogel although this constrained environment mimics one of the microalgae natural habitats soil we have limited understanding of the microalgae behaviour within such an environment we will first investigate how cells move within a porous environment and how they respond to light with the goal of using light for 3d patterning we will then explore how the hydrogelbased living material can be locally mechanically reinforced with cellsecreted polymers and finally how to harness the microalgae light response as a mean to create a soft actuator my independent research team uniquely combines expertise in microalgae cell biophysics and in engineered living materials and we are thus ideally positioned to take on the challenge of creating microalgaebased living materials dynamically controlled by light this erc project opens up a new class of materials with lifelike functionalities such as shape change and lightsensing which are likely to find wide applications from soft robots to photosynthetic devices
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agnostic risk management for high impact low probability events
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agile will design develop and apply a holistic methodological framework and practical tools for understanding assessing managing and communicating hilps events with a systemic risk and resilience perspective the project will combine and integrate a wide range of established and innovative methodologies into a novel and replicable multisectoral risk and resilience stress testing methodology to better understand systems theory lateral thinking strategic foresight machine learning anticipate scenario building tabletop exercises multicriteria decision analysis machine learning and manage resilience assessment capability development strategic training these approaches and services will be cocreated within a unique transdisciplinary consortium of research organisations ngos smes first responders and local and regional authorities the scalable and replicable methods will enable for the identification of common points of failure of critical societal functions in response to compounding low probability high impact threats as well as provide recommendations for both riskinformed system hardening and threatagnostic systemic recovery the project will ultimately improve the strategic and operational risk management capacities and capabilities of drm stakeholders on local regional and national level and thus strengthening the societal resilience to new and emerging risks in europe and beyond the project provides the means and the methodology to ensure a wide ranging impact of its results to not only improve the understanding anticipation and management of hilp risks and events but the direct and wideranging contribution to key european and international policy priorities and global challenges such as the eu disaster risk management policies in particular ucpm the european green deal priorities eu climate adaptation strategy as well as the eu security union strategy
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in vivo metabolic imaging at low magnetic field
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magnetic resonance imaging mri is an excellent technique for medical diagnosis nonetheless people from rural areas and lowincome countries cannot access mri due to its high associated cost in recent years lowfield mri has emerged as a potential solution to increase access to mri but at the cost of reduced signal sensitivity this is a limiting factor in terms of resolution traceable quantities of metabolites and early detection of tumor tissuein this context hyperpolarization hp has emerged as the most promising technique to compensate for the sensitivity losses at low magnetic fields hp can enhance signal intensity by 10000 times providing enough signal to image even species at low concentrations such as metabolites internalized by cancer cells here the first in vivo metabolic imaging methodology with hyperpolarization at low magnetic fields is proposed the project involves the development of 1h and hp 13c mri at low field the study of enzymatic conversion from hp pyruvate to other metabolites and in vivo metabolic tumor imaging in mice parahydrogeninduced polarization phip will be used to generate the hp contrast agent phip offers several advantages including low costs low instrumentation demands rapid highthroughput and scalable production of hp agents in the liquid statethe combination of lowfield mri with phip 13c has the potential to provide a method for early cancer detection in a lowcost scanner
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optimality and resetting investigation on nonequilibrium
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orion project optimality resetting investigation on nonequilibrium poses three different problems relevant at both the fundamental and applied level apart from their independent relevance the solution of all three problems will serve to a greater purpose providing a solid basis for the innovative use of optimal control theory to push the boundaries of knowledge within the general field of nonequilibrium statistical mechanics this action will involve the integration of the researcher in the very active group of interdisciplinary and nonequilibrium physics fine at university of seville with a strong background on the theory of mesoscopic systemseg colloidal particles for which fluctuations are important and the dynamics is thus stochastic more specifically the research objectives of orion splits into i the generalization of optimal control theory to connecting nonequilibrium steady states ii the optimization of stochastic heat engines and iii the minimization of first passage time in resetting systems with stochastic return the achievement of these objectives will provide not only specific answers to pertinent questions for the above hot topics in the field but also shed light on the future of investigation on nonequilibrium systems remarkably the impact of our research transcends the purely theoretical interest focusing on problems with future technological potential like the optimization of nanodevicesmaximizing their power andor efficiency
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selfreferenced xuv transient reflectivity spectroscopy attosecond electron dynamics of 2d layered materials
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the research and development of novel layered and 2d materials is at the center of a focused interest in the material sciences the large photon coupling of their excitonic excitations and their varying degrees of localization control over coupling to other degrees of freedom as well as novel spin and momentumdependent properties arising from symmetry and topology have made 2d materials a desirable platform for the development of new applications ranging from new photovoltaic and optoelectronical devices to spintronic and quantum ie coherent data transport and storage devices since the coupling of electronic states to other material degrees of freedom eg lattice excitonic or spinpolarized states might lead to desired or undesired behavior in these materials powerful timeresolved experimental methods are needed to disentangle and understand their electron dynamics and achieve the implementation of the desired applications the ultrashort timescales that govern electron dynamics warrant the application of novel methods such as xuv transient absorption xtas or xuv transient reflectivity spectroscopy xtrs which achieve temporal resolutions on the natural timescale of electronic motion ie attosecond timescales timeresolved corelevel spectroscopy using attosecond pulses from high harmonic generation hhg offers intriguing opportunities to study the electron dynamics with high energyresolution and unprecedented temporalresolution with elementspecific insight into the materials bandstructurethe major goal of this proposed work is the advancement of xtrs and its application to study excitations in layered materials down to the fewlayer limit a novel interferometric and heterodyne approach to overcome existing limitations of xtrs will be developed and applied to a series of materials where time resolved studies will lead to desirable insight into the ultrafast coupled dynamics of carriers excitons their spin and the lattice
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the first energy and costefficient disruptive zld technology for dredged material management allowing circular economy and zero pollution
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dredging is an essential activity to maintain maritime and river routes coastal protection to flooding among others every year over 2 bm3 of sediments are dredged around the world 2040 of which are highly polluted and must be treated before being disposed to landfill as current treatment and separation technologies do not allow to costefficiently valorise the water and the solids from this dredged material water challenge has developed and patented the first energyefficient truly zero liquid discharge zld technology able to separate 100 of dredged material into fresh water and crystalized solids in one step without chemicals and with very low energy consumption 20 kwhm3the aim of this project is to develop a pilot plant of 10 m3day of capacity to separate and valorise the water and solids from dredged materials this plant will be pivotal to showcase the technology and business model before scaling it and replicating it around europe
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controlling colloidal gels for novel sustainable materials
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transformative advances in product formulation are required to meet the demand for sustainability across a wide range of eupriority industrial areas colloidal gels complex outofequilibrium soft matter systems are core components in many of the formulations encountered therein including building materials eg cement energy materials eg batteries and fuel cells consumer care and food products and medicine current industrial practice requires delicate balancing between thermodynamic parameters composition and interactions quenching kinetics and processing conditions to achieve gel structures with the desired material performance eg mechanical thermal or electrical properties without a robust physical understanding of how the microstructure can be controlled and how this links to material properties this balancing remains limited to trial and error recent advances in colloidalgel physics strongly imply that the rational design of colloidal gel properties is within reach this design is based on tuning gel microstructure via external stimuli such as shear ultrasound and magneticelectric fields and the addition of nonbrownian inclusions the cocogel doctoral network will enable the translation from the current academic state of the art to industrial practice focusing on these routes to controlling microstructure we will bring together 6 academic and 6 industrial partners experts in a range of experimental computational and theoretical techniques who can realize the creation of new sustainable materials and production processes via these routes key to the success of our industrial doctoral training network is a deepening and extending of existing collaborations as well as the training of a new generation of researchers with both multidisciplinary expertise in soft materials and practical experience engaging with industry these will drive further sustainable development over a wide range of european industries
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better contrails mitigation
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aviation contributes to about 5 of the total anthropogenic climate change when including nonco2 effects eg contrail formation and the impact of nox emissions on ozone and methane among various nonco2 effects the contrailcirrus radiative forcing is the largest 23 with large uncertainties the most critical affecting factor is the huge weatherinduced variability of the radiative impact of individual contrails this is the quantity becom will predict better since the knowledge of the individual radiative forcing is the basis for avoidance of just those contrails that contribute most to the overall climate impact once this is standard it will be possible to formulate adequate mitigation measures and develop policydriven implementation schemes becom will address the uncertainties related to the forecasting of persistent contrails and their weatherdependent individual radiative effects becom focuses on 1 obtaining a larger and higher resolution database of relative humidity and ice supersaturation at cruise levels for assimilation into numerical weather prediction nwp models 2 providing more adequate representation of ice clouds in their supersaturated environment in the nwp models and 3 validation of the predictions to determine and reduce the remaining uncertainties of contrail forecasts to facilitate the assimilation and validation process becom will develop a novel hybrid artificial intelligence algorithm based on the contrail prediction becom will develop a policy framework for effective contrail avoidance through a trajectory optimization approach becom will enable a better understanding of contrails climate impact and formulate recommendations on how to implement strategies to enable air traffic management to reduce aviations climate impact the becom consortium builds on its knowledge and expertise covering a wide spectrum from atmospheric science and climate research to aviation operations research and policy development
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naturecolours natural colours delivered by yeast fermentation
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colour is an essential characteristic of food associated with quality freshness and taste perception natural and synthetic food dyesare added to processed foods to enhance or correct variations and give an expected colour to colourless foods such as soft drinks orcandies many synthetic colours cause hyperactivity in children trigger hypersensitivity reactions and some are carcinogenic in animalstudies natural colours do not have such adverse effects and are even healthpromoting while natural colours are in high demandtheir natural sources are limitedthe goal of naturecolours project is to create a novel technology for making natural colours by yeast fermentation the projectwill bring a pallet of natural colours with healthbeneficial effects to the consumer create new industrial processes and new jobs ineurope and contribute to the sustainable bioeconomy
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modeling and reduction of aeroacoustics sources of interaction noise in aviation
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the target of climateneutral aviation has led to a strong increase in the size of new propulsion systems resulting in their lowered distance to the airframe components this causes new aerodynamic interactions with heavy distortion of the turbulent flow determining unpredictable sources of noise mitigating this interaction noise would allow to deploy radically new aircraft configurations capable of reducing up to 20 of the current aviation emissionswhile studies from literature have tried to correct discrepancies larger than 10 db from acoustic predictions by aposteriori tuning the models to very specific flow patterns recent results from my team have shed light on the physics behind the unpredictability of these noise sources results hinted that the geometrical deformation of the turbulent flow from its original pattern might explain the origin of interaction noiseto solve this puzzle with morasina i aim at first understanding how the flow and the turbulence are distorted in archetypal interactions between rotating and stationary aerodynamic objects my objective is to discover the unknown mathematical formulation to model this distortion mechanism and to use it to create the first holistic acoustic model for predictions of interaction noiseby innovatively describing the interaction mechanisms with mathematical functions related to the geometrical distortion of the flow i will find an answer to whether different flow fields can be assimilated in a unique fundamental flow pattern with this knowledge i will create the first acoustic model based on a mathematical flow twin to accurately predict interaction noisefor maximum impact on the society i will extend the model to equipollent interaction mechanisms with a neural network approach trained on the results allowing the use of the prediction framework for reducing interaction noise in the design of the next generation of zeroemission and silent aircraft
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rapid programmable photonic integrated circuits
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photonic integrated circuits enable trapping of photons the fundamental particles of light in a waveguide on a chip to allow their manipulation similar to electrons in classical integrated circuits while photonic circuits offer superior performance in speed and energy efficiency their application in computing has so far been limited by their programmability electronic integrated circuits are based on transistors that until recently have become both smaller and more energyefficient according to moores law photonic circuits on the other hand are controlled through phase modulators that typically rely on the same materials used in the electronic industry but suffer from fundamental limitations which so far have hindered the implementation of dedicated scalable photonic computing hardware we propose to explore an innovative and efficient phase modulation technology utilizing the novel material platform of atomically thin semiconducting transition metal dichalcogenides that promises to outperform conventional technologies in all key performance metrics including energy consumption modulation efficiency and optical losses one promising integrated photonics platform to host these novel devices is represented by laserwritten waveguides that allow for a rapid design cycle thereby drastically reducing timescales provided by conventional semiconductor foundries this erc proof of concept project aims at leveraging atomically thin semiconductors to implement programmable photonic integrated circuitry
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community ocean farms and local business clusters
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coastal and terrestrial fisheries communities in europe often economically marginalised are likely to face severe impacts as climate change becomes more acute although progress on climate mitigation and adaptation from national governments remains slow local development actions can also address these impacts from the bottom up transformation to a postcarbon society undoubtedly requires additional targeted support and extensive educational activities at the local level the primary objective of cool blue is to create frameworks for communities to selforganise and rediscover healthy lowimpact seafood this healthy beautiful tasty food simultaneously revitalises ecosystems while bringing communities closer together creating resilient selfsufficient and selfsustaining socioecological systems which can withstand emerging global threats such as climate and demographic change the cool blue project will create a northern european network of communityled initiatives in the baltic and north sea basins this network will facilitate closer collaboration between regions combining efforts across parallel projects and initiatives eg prep4blue bluemissionbanos while accelerating the development of commercially selfsustaining lowimpact inclusive ocean farming systems in line with the mission work programme to contribute to the recovery of our ocean and waters by 2030
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subchromosomal regulation of mitotic transcription inhibition
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chromosome condensation during mitosis has long been assumed to render mitotic chromatin incompatible with transcription however recent evidence shows that some chromosomal regions eg centromeres some genes are transcribed in mitosis these findings imply that mitotic transcription inhibition mti is not a global event along the entire chromosome instead i propose that mitotic transcriptional silencing is spatially regulated allowing specific loci to evade mti and maintain their transcriptiontesting this novel hypothesis is challenging due to our poor understanding of the mechanisms driving mti additionally commonly used techniques to study transcription eg genomewide approaches provide snapshots of the process but lack temporal resolution to dissect fast changes in transcription with subscript i will implement an advanced imaging tool in live cells to uncover the dynamics of ongoing transcription throughout mitosis for selected loci i will apply this approach to selected genes to test how transcription regulation in mitosis varies depending on gene architectureidentity in parallel i will make use of a putative mti factor my preliminary observations to manipulate the transcriptional state of selected genes during mitosis both strategies will capitalize on my vast expertise in dcas9 use for chromosome targeting which i will further exploit to imaging rnas dcas13 ongoing work in the host lab on chromosome assembly and novel mechanisms that drive mti provides an excellent environment for project implementationthe completion of this project will uncover how different genes display unique kinetics of transcriptional regulation during mitosis and how mti is regulated at the subchromosomal level challenging current views on how mitotic transcription shutdown occurs it will also provide novel tools and concepts to explore how mti can actively impact mitotic fidelity transcriptional control cell physiology and potentially disease
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timeevolving stochastic manifolds
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uncertainty is all around us and caused for example by the nature of a problem as in quantum mechanics the lack of our precise knowledge as in porous media or inaccuracies in measurements as in experiments with imperfect equipment while traditionally and due to the lack of computing power science and technology relied on deterministic models recent developments allow to include randomness this trend requires efficient simulation methods for models with uncertainty in spacetime problems such as moving biological cells and the surface of the ocean the randomness could be modeled by a stochastic process given explicitly or described by stochastic pdes fast and accurate methods for sampling the stochastic processes are the key when computing statistical quantities of the advanced modelsthe main contribution of the project is the development of a theoretical framework for evolving stochastic manifolds and their efficient simulation with analyzed algorithms special emphasis is paid to the situation when the evolving stochastic manifold is a moving surface disturbed by external forces and described by stochastic pdes the main steps of the project are divided into three objectives obj a from random fields on manifolds to stochastic manifolds obj b from stochastic processes to evolving stochastic manifolds obj c solving pdes on stochastic manifoldsthe challenges are tackled based on recent advances in the simulation of gaussian random fields on manifolds and their analysis obtained by the research team of the pi this new breakthrough paves the way for the development of sampling methods for stochastic processes on manifolds and ultimately to evolving stochastic manifoldsto reach these goals the pis research group is complemented by specialists in geometric numerical integration numerical methods for stochastic pdes and spatial statistics
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elucidating the underwater adhesion of the brown algae fucus vesiculosus
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many marine organisms of the intertidal zone like mussels barnacles and various algae must form strong attachments to the substrate in their environment in order to resist forces of crashing waves therefore they evolved highperformance underwater adhesives which are able to stick to various surface chemistries a feat unmatched by current glues on the market understanding the chemistry and formation process of these adhesives has great potential for the development of synthetic underwater glues which are of high interest for medical and industrial applications here i propose to conduct research on the underwater adhesion of the brown macroalgae fucus vesiculosus analyzing its composition structure and adhesive properties for this purpose the early formation process shortly after the fertilization of fucus egg cells will be analyzed using a combination of traditional histology and advanced electron microscopic and spectroscopic techniques once key building blocks have been identified their dynamic secretion and assembly process will be followed over time additionally the curing of the adhesive and the involved crosslinking reactions will be investigated after different time points elucidating key chemical principles of the complex formation of this underwater adhesive has the potential to inspire the development of novel and sustainable adhesives with a wide range of applications
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quantumenhanced shadows scalable quantumtoclassical converters
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largescale quantum experiments do not work in isolation substantial classical computing power is required to control the experiment and process the results this necessarily creates informationtransmission bottlenecks at the interface between quantum and classical realms these bottlenecks create scalability issues that prevent us from using existing architectures to the best of their capabilities and may even impair our ability to further scale up system sizesin this project we adopt a unifying framework that takes into account all computing resources quantum and classical we develop quantumtoclassical converters to overcome informationtransmission bottlenecks dubbed shadows they leverage randomization as well as quantumenhanced readout strategies to obtain a succinct classical description of an underlying quantum system that can then be used to efficiently predict many features at once the shadow paradigm is compatible with nearterm quantum hardware and utilizes genuine quantum effects that do not have a classical counterpart building on these ideas we also establish rigorous synergies between quantum experiments and classical machine learning shadow learning protocols use shadows to succinctly represent training data obtained from actual quantum experiments a classical training stage then enables datadriven learning of genuine quantum phenomena finally we develop new tools to ensure reliable execution on current quantum hardware thus bridging the gap between theory and experimentmy interdisciplinary skill set combines methods from modern computer science with quantum information and has already led to numerous highimpact contributions eg 1 nature physics with more than 350 citations and 2 science publications these insights form the basis for this larger project where we lay the foundation for scalable and practical quantum data processing and learning that can keep up and grow with future improvements in quantum technology
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exercised breastmilk a kickstart for childhood obesity prevention
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innovative preventive strategies are urgently required to halt the rising prevalence of childhood obesity given the inefficacy of current interventions mothertochild transmission of obesity accounts for a large proportion of childhood obesity more than what can be explained by genes nutrition during the first 3 months of life is crucial with rapid weight gain in this period associated with subsequent obesity breastmilk is considered optimal for infant nutrition but its composition depends on the mothers metabolic health the concentrations of some breastmilk compounds linked to infant obesity are associated with maternal body mass index maternal lifestyle factors such as diet can alter breastmilk composition little is however known about the effect of exercise during lactation exercise is a major regulator of systemic metabolism affecting multiple tissues and organs in this ambitious interdisciplinary project i will determine how exercise during lactation influences breastmilk composition in women with overweightobesity and whether exerciseinduced changes in breastmilk will influence infant obesity risk my preliminary data show acute effects of exercise on breastmilk concentrations of adiponectin and lipid metabolites relevant for energy metabolism in exmilk i will determine both acute effects and adaptations after regular exercise on a complex matrix of breastmilk compounds by linking breastmilk data to comprehensive data for the infants i will investigate the potential mechanisms underlying the effects of maternal exercise on infant obesity risk mediated by changes in breastmilk composition to reach my goals i will perform goldstandard randomised trials and analyse biological samples from mothers and infants on multiomics platforms my experience in metabolomics and exercise intervention trials in reproductiveaged women will enable me to break new ground in understanding how exercise during lactation modifies infant obesity risk
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selfimposed restrictions understanding why politicians adopt anticorruption policies
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corruption is a pressing global challenge which imposes substantial costs on the lives of people and businesses and undermines citizens trust in democratic institutions anticorruption reforms and political ethics regulation have also grown dramatically in european countries but display varying degrees of success while scandals policy diffusion and political will have been advanced as explanations for the success or failure of anticorruption policies it not yet understood under which specific conditions politicians will adopt anticorruption policies acps aimed at changing their own status quo and conduct if we dont know the answer to this question then anticorruption efforts are doomed to failure unlike previous studies that focused on the implementation of broad anticorruption reforms in the public sector or on the behaviour of participants acting out the part of policymakers in controlled laboratory experiments the novelty of the sir project is that it will investigate the specific conditions that surrounded the adoption of each anticorruption law aimed at political officials namely party funding conflict of interest and lobbying the focus on policies will allow the research to go beyond simple national variations and grasp the conditions under which the policies were adopted in any given time this research will be divided into two phases i the creation of an original database with the contextual conditions surrounding the adoption of acps and the adoption of greco recommendations in eu countries ii quantitative and qualitative comparative analysis of the contextual conditions surrounding the adoption of each specific acps dedicated to political office holders
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resolving ambiguities in flow boiling within micropassages integrated modeling and experiments
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electronic products are progressively smaller and more powerful resulting to an exponential increase in the generated residual heat their effective and environmentalfriendly cooling is therefore of upmost importance for many applications such as data centres fuel cells insulatedgate bipolar transistors lithiumion batteries and photovoltaic cells with a market value of several billions of dollars worldwide flow boiling within micropassages has been proven as one of the most efficient cooling strategies for such highpower density electronics however such solutions are not yet commercially available this is due to a lack of a deep understanding of the underpinned flow and transport processes and unresolved ambiguities in microscales and hence of reliable and easytouse thermal design tools for smallscale components refine aims to give light at such crucial ambiguities utilising a synergic combination of novel volume of fluid vof based numerical simulations and tailored highresolution experimental diagnostics dr andredaki will develop a novel cuttingedge simulation tool starting from an already enhanced vof solver that she has been developing in the last years this will be validated against parallel advanced experimental measurements on flow boiling that she will perform using single and multiple parallel microchannel heat sinks the final optimised and validated numerical solver will then be applied for a wide series of parametric simulations that in combination with additional laboratory measurements will form a unique database that will lead to the development of novel physicsbased design correlations for flow boiling microchannel heat sinks the wordleading expertise of prof moreira who will supervise this project on the experimental techniques for microscale boiling guarantees the highest level of knowledge transfer enabling dr andredaki to further develop her skills and enhance her future career opportunities in academia
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elucidating the crosstalk between the immune system and brown adipose tissue in humans
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brown adipose tissue bat is a promising therapeutic target to improve cardiometabolic health however bat metabolism is dysfunctional in obesity hence it is highly relevant to ascertain which mechanisms modulate bat function and how it can be improved in this contextmice studies indicate that the immune cellsbrown adipocytes molecular interactions within bat modulate its function indeed mice knockout for the transcript mecp2 in bat macrophages show impaired bat function and develop obesity further cold acclimation activates specific subsets of infiltrated immune cells which improves bat function altogether points to infiltrated immune cells as key players regulating bat but their identity and role and if they can be targeted to activate bat in humans is unknownthe main questions we aim to tackle are i which are the immune cell populations within human bat ii does local inflammation exist in bat of obese subjects is it related to their disrupted bat oxidative and metabolic capacity iii is the bat oxidative and metabolic capacity improvement after a 3month cold acclimation driven by changes in bat immune cell profile to answer these questions immunobat will characterize the immune cell profile of bat in lean and obese subjects using novel singlecell omics in samples obtained by neck surgery bat oxidative and metabolic capacity will be assessed in vivo by stateofart methods combining the use of 15oo2 and 15oh2o pet measures with in vitro mitochondrial respiration assays of brown adipocytes these measures will be repeated in obese subjects after a 3month cold acclimation the most powerful stimulus to activate batimmunobat will provide new mechanistic insights into obesity pathogenesis at the same time that it expects to find new tools to improve cardiometabolic health by activating bat further it will promote the fellows training in adipose biology and immunology and his growth as an independent and mature researcher
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cognitive edgecloud with serverless computing
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edgeless is set to efficiently operate serverless computing in extremely diverse computing environments from resourceconstrained edge devices to highlyvirtualised cloud platforms by taking advantage of aiml solutions it will enable automatic deployment and reconfiguration to fully exploit compute resources available on clusters of nearby edge nodes edgeless will define novel orchestration systems that provide a flexible horizontally scalable compute solution able to fully use heterogeneous edge resources while preserving vertical integration with the cloud and the benefits of serverless including its application programming model it will address edge systems at design stage particularly targeting lowlatency highreliability applications with computationallyintensive tasks requiring specialised hardware or a trusted environment this ambitious challenge will be met via distributed computing solutions to partition the edge environment in clusters each managed as a local decentralised serverless platform in each cluster orchestration and scheduling of jobs will run smoothly thanks to realtime monitoring of shortterm loadnetworkenergy conditions and anticipatory aipowered algorithms to manage lightweight virtualised lambda executors eg unikernels environmental sustainability will be boosted by dynamically concentrating resources physically eg by temporarily switching off faredge devices or logically eg by dispatching tasks towards a specific set of nodes at the expense of performancetolerant applications clusters will cooperate with each other and with all the layers in the edgecloud continuum to compose complex applications ondemand through a faas paradigm edgeless innovations will be validated through testbeds nearedge mec and two smalldevice lab setups integrated through a federated edgecloud infrastructure and three pilots autonomous smart city surveillance internet of robotic things and healthcare assistants
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new european bauhaus solutions in food living heritage and conviviality
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convivium is an interdisciplinary and intersectorial coalition of public and private european partners working together to bring a cultural dimension to the european green deal through the leveraging of the material semiotic and symbolic power of food the consortium sees food cultures as a living heritage that reflects changes in society and contributes to local wellbeing with widereaching impacts convivium mobilizes numerous creative and transformative forces in the fields that inform the new european bauhaus to ensure sustainability and positive societal transformation through the medium of food heritage it offers attractive and sustainable culturalbased solutions which will bring about a range of cultural and economic applications available to different target groups they include architectureanddesignbased prototypes that will support farmers and agricultural cooperatives to work in symbiosis with the environment with tradition and with stateofthe art advances cultural events and interventions that bring food the arts and the humanities together to positively change the mindsets of food producers and consumers new organizational models that champions intercultural generational and intersectional visions through the medium of food across local populations and digital tools to reinforce the presence of food heritage in institutions such as museums and historical sites convivium will achieve this commitment supported by solid managerial scientific collaborative and technical structures which are in constant dialogue to ensure that the unlocking of food heritage translates into solutions grounded in the needs and opportunities of local communities in stateoftheart social science and humanities approaches and methods and in synergies between traditional crafts and cuttingedge technological developments
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using lake sediments to reconstruct soil weathering trajectories over the holocene
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chemical weathering is a central biogeochemical process that shapes the earths critical zone cz regulates the global carbon cycle and sets the pace for nutrient delivery to soils and ecosystems most knowledge on the rates and controls on chemical weathering are from laboratory experiments and from the shortterm observation of modern soil and river systems in contrast little is known about past changes of chemical weathering over hundreds to thousands of years which limits our understanding of how longlasting humanclimateecosystem interactions have impacted the cz trajectories because of this knowledge gap it is not possible to fully understand the response and feedbacks of the cz to the climatic and environmental perturbations of the holocene period nor to predict their future evolution during the anthropocene to fill this gap lakeswitch aims to produce new quantitative weathering records over 102104 year timescales with a temporal focus on the holocene period there are 3 main challenges 1 developing quantitative proxies of chemical weathering 2 calibrating these proxies for paleoreconstructions 3 measuring these proxies in paleoarchives of 102104 year timescale integration to provide these records we will measure lithium and strontium isotopic proxies in lake detrital and authigenic carbonates and biogenic silica sediment archives to calibrate these proxies and archives we will use a sourcetosink approach and track weathering product pathways from soils through rivers to lake deposits then we will apply these proxies back in time in holocene lake cores as rapidlyeroding mountain dominate the global chemical erosion budget we will focus on the study of the european alps new data from alpine watersheds and lake records spanning gradients in erosion runoff and land use will serve to quantify and model the impact of climate and human drivers on soil trajectories from the onset of the holocene to the anthropocene
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