bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

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Androgenablation is an umlsterm, therapy is an umlsterm, choice is an umlsterm, treatment is an umlsterm, metastatic is an umlsterm, prostate cancer is an umlsterm, patients is an umlsterm, disease is an umlsterm, androgenablation is an umlsterm, castration is an umlsterm, apoptotic is an umlsterm, treatment is an umlsterm, quality of life is an umlsterm, patients is an umlsterm, toxicity is an umlsterm, treatment costs is an umlsterm, tumor is an umlsterm, survival is an umlsterm, clinical trials is an umlsterm	DerUrologeA.80370153.eng.abstr_task1	Sentence: Androgenablation is the therapy of choice for the treatment of advanced and metastatic prostate cancer . However , in more than half of the patients the disease will ultimately progress within 2 years . Intermittent androgenablation through medical castration maintains the apoptotic potential . By periodically changing phases on and off treatment the quality of life of the patients is improved . Apart from reduced toxicity treatment costs are lowered and tumor progression is possibly delayed . In how far survival is influenced is presently not clear and remains to be evaluated in further clinical trials . Instructions: please typing these entity words according to sentence: Androgenablation, therapy, choice, treatment, metastatic, prostate cancer, patients, disease, androgenablation, castration, apoptotic, treatment, quality of life, patients, toxicity, treatment costs, tumor, survival, clinical trials Options: umlsterm	[ "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Androgenablation is the therapy of choice for the treatment of advanced and metastatic prostate cancer . However , in more than half of the patients the disease will ultimately progress within 2 years . Intermittent androgenablation through medical castration maintains the apoptotic potential . By periodically changing phases on and off treatment the quality of life of the patients is improved . Apart from reduced toxicity treatment costs are lowered and tumor progression is possibly delayed . In how far survival is influenced is presently not clear and remains to be evaluated in further clinical trials .	[ "Androgenablation", "is", "the", "therapy", "of", "choice", "for", "the", "treatment", "of", "advanced", "and", "metastatic", "prostate", "cancer", ".", "However", ",", "in", "more", "than", "half", "of", "the", "patients", "the", "disease", "will", "ultimately", "progress", "within", "2", "years", ".", "Intermittent", "androgenablation", "through", "medical", "castration", "maintains", "the", "apoptotic", "potential", ".", "By", "periodically", "changing", "phases", "on", "and", "off", "treatment", "the", "quality", "of", "life", "of", "the", "patients", "is", "improved", ".", "Apart", "from", "reduced", "toxicity", "treatment", "costs", "are", "lowered", "and", "tumor", "progression", "is", "possibly", "delayed", ".", "In", "how", "far", "survival", "is", "influenced", "is", "presently", "not", "clear", "and", "remains", "to", "be", "evaluated", "in", "further", "clinical", "trials", "." ]	[ "umlsterm" ]
Androgenablation, therapy, choice, treatment, metastatic, prostate cancer, patients, disease, androgenablation, castration, apoptotic, treatment, quality of life, patients, toxicity, treatment costs, tumor, survival, clinical trials	DerUrologeA.80370153.eng.abstr_task2	Sentence: Androgenablation is the therapy of choice for the treatment of advanced and metastatic prostate cancer . However , in more than half of the patients the disease will ultimately progress within 2 years . Intermittent androgenablation through medical castration maintains the apoptotic potential . By periodically changing phases on and off treatment the quality of life of the patients is improved . Apart from reduced toxicity treatment costs are lowered and tumor progression is possibly delayed . In how far survival is influenced is presently not clear and remains to be evaluated in further clinical trials . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Androgenablation is the therapy of choice for the treatment of advanced and metastatic prostate cancer . However , in more than half of the patients the disease will ultimately progress within 2 years . Intermittent androgenablation through medical castration maintains the apoptotic potential . By periodically changing phases on and off treatment the quality of life of the patients is improved . Apart from reduced toxicity treatment costs are lowered and tumor progression is possibly delayed . In how far survival is influenced is presently not clear and remains to be evaluated in further clinical trials .	[ "Androgenablation", "is", "the", "therapy", "of", "choice", "for", "the", "treatment", "of", "advanced", "and", "metastatic", "prostate", "cancer", ".", "However", ",", "in", "more", "than", "half", "of", "the", "patients", "the", "disease", "will", "ultimately", "progress", "within", "2", "years", ".", "Intermittent", "androgenablation", "through", "medical", "castration", "maintains", "the", "apoptotic", "potential", ".", "By", "periodically", "changing", "phases", "on", "and", "off", "treatment", "the", "quality", "of", "life", "of", "the", "patients", "is", "improved", ".", "Apart", "from", "reduced", "toxicity", "treatment", "costs", "are", "lowered", "and", "tumor", "progression", "is", "possibly", "delayed", ".", "In", "how", "far", "survival", "is", "influenced", "is", "presently", "not", "clear", "and", "remains", "to", "be", "evaluated", "in", "further", "clinical", "trials", "." ]	[ "umlsterm" ]
Significant is a Qualifier, motor complication is a Condition, Drugs is a Drug, acetylcholine is a Drug	NCT03011476_exc_task0	Sentence: Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Drug	[ "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "O", "O", "B-Drug", "O", "O" ]	Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism	[ "Significant", "motor", "complication", "affecting", "daily", "activities", "\n", "Drugs", "related", "to", "acetylcholine", "metabolism", "\n" ]	[ "Qualifier", "Condition", "Drug" ]
Significant is a Qualifier, motor complication is a Condition, Drugs is a Drug, acetylcholine is a Drug	NCT03011476_exc_task1	Sentence: Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism Instructions: please typing these entity words according to sentence: Significant, motor complication, Drugs, acetylcholine Options: Condition, Qualifier, Drug	[ "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "O", "O", "B-Drug", "O", "O" ]	Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism	[ "Significant", "motor", "complication", "affecting", "daily", "activities", "\n", "Drugs", "related", "to", "acetylcholine", "metabolism", "\n" ]	[ "Qualifier", "Condition", "Drug" ]
Significant, motor complication, Drugs, acetylcholine	NCT03011476_exc_task2	Sentence: Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism Instructions: please extract entity words from the input sentence	[ "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "O", "O", "B-Drug", "O", "O" ]	Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism	[ "Significant", "motor", "complication", "affecting", "daily", "activities", "\n", "Drugs", "related", "to", "acetylcholine", "metabolism", "\n" ]	[ "Qualifier", "Condition", "Drug" ]
Osteomyelitis is an umlsterm, infection is an umlsterm, bone marrow is an umlsterm, osteomyelitis is an umlsterm, form is an umlsterm, Mycobacterium tuberculosis is an umlsterm, infection is an umlsterm, form is an umlsterm, children is an umlsterm, adults is an umlsterm, tibia is an umlsterm, femur is an umlsterm, tuberculosis is an umlsterm, osteomyelitis is an umlsterm, osteomyelitis is an umlsterm, viruses is an umlsterm, fungi is an umlsterm, echinococcus is an umlsterm, osteomyelitis is an umlsterm, osteomyelitis is an umlsterm, abscess is an umlsterm, leucocytes is an umlsterm, granulation tissue is an umlsterm, bone is an umlsterm, tuberculosis is an umlsterm, granulomas is an umlsterm, necrosis is an umlsterm, epithelioid cells is an umlsterm, giant cells is an umlsterm, forms is an umlsterm, osteomyelitis is an umlsterm, antibiotics is an umlsterm, complications is an umlsterm, secondary is an umlsterm, form is an umlsterm	DerRadiologe.60360781.eng.abstr_task0	Sentence: Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form .	[ "Osteomyelitis", "is", "an", "infection", "of", "the", "bone", "marrow", "caused", "by", "both", "non", "-", "specific", "and", "specific", "agents", ".", "Non", "-", "specific", "endogenic", "osteomyelitis", "represents", "the", "most", "frequent", "form", ",", "followed", "by", "the", "specific", "form", "caused", "by", "Mycobacterium", "tuberculosis", "infection", ".", "Typically", ",", "the", "non", "-", "specific", "form", "occurs", "in", "children", "and", "young", "adults", ",", "and", "the", "sites", "most", "frequently", "affected", "are", "the", "distal", "and", "the", "proximal", "ends", "of", "the", "tibia", "and", "femur", ".", "In", "tuberculosis", ",", "osteomyelitis", "is", "predominantly", "located", "in", "the", "vertebral", "bodies", ".", "In", "rare", "cases", "osteomyelitis", "can", "be", "caused", "by", "viruses", ",", "fungi", "or", "echinococcus", ".", "It", "may", "also", "occur", "as", "so", "-", "called", "acute", "endogenic", "osteomyelitis", ",", "such", "as", "plasmocellular", "osteomyelitis", "and", "Brodie", "'s", "abscess", ".", "Histologically", ",", "dense", "infiltration", "of", "leucocytes", ",", "granulation", "tissue", "and", "bone", "sequesters", "can", "be", "seen", ".", "In", "tuberculosis", "granulomas", "with", "central", "necrosis", ",", "epithelioid", "cells", "and", "giant", "cells", "of", "Langhans", "type", "are", "characteristically", "found", ".", "Most", "forms", "of", "acute", "osteomyelitis", "can", "be", "successfully", "treated", "with", "antibiotics", ",", "leading", "to", "complete", "healing", "without", "complications", ".", "Only", "a", "few", "reported", "cases", "develop", "into", "a", "secondary", ",", "chronic", "form", "." ]	[ "umlsterm" ]
Osteomyelitis is an umlsterm, infection is an umlsterm, bone marrow is an umlsterm, osteomyelitis is an umlsterm, form is an umlsterm, Mycobacterium tuberculosis is an umlsterm, infection is an umlsterm, form is an umlsterm, children is an umlsterm, adults is an umlsterm, tibia is an umlsterm, femur is an umlsterm, tuberculosis is an umlsterm, osteomyelitis is an umlsterm, osteomyelitis is an umlsterm, viruses is an umlsterm, fungi is an umlsterm, echinococcus is an umlsterm, osteomyelitis is an umlsterm, osteomyelitis is an umlsterm, abscess is an umlsterm, leucocytes is an umlsterm, granulation tissue is an umlsterm, bone is an umlsterm, tuberculosis is an umlsterm, granulomas is an umlsterm, necrosis is an umlsterm, epithelioid cells is an umlsterm, giant cells is an umlsterm, forms is an umlsterm, osteomyelitis is an umlsterm, antibiotics is an umlsterm, complications is an umlsterm, secondary is an umlsterm, form is an umlsterm	DerRadiologe.60360781.eng.abstr_task1	Sentence: Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form . Instructions: please typing these entity words according to sentence: Osteomyelitis, infection, bone marrow, osteomyelitis, form, Mycobacterium tuberculosis, infection, form, children, adults, tibia, femur, tuberculosis, osteomyelitis, osteomyelitis, viruses, fungi, echinococcus, osteomyelitis, osteomyelitis, abscess, leucocytes, granulation tissue, bone, tuberculosis, granulomas, necrosis, epithelioid cells, giant cells, forms, osteomyelitis, antibiotics, complications, secondary, form Options: umlsterm	[ "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form .	[ "Osteomyelitis", "is", "an", "infection", "of", "the", "bone", "marrow", "caused", "by", "both", "non", "-", "specific", "and", "specific", "agents", ".", "Non", "-", "specific", "endogenic", "osteomyelitis", "represents", "the", "most", "frequent", "form", ",", "followed", "by", "the", "specific", "form", "caused", "by", "Mycobacterium", "tuberculosis", "infection", ".", "Typically", ",", "the", "non", "-", "specific", "form", "occurs", "in", "children", "and", "young", "adults", ",", "and", "the", "sites", "most", "frequently", "affected", "are", "the", "distal", "and", "the", "proximal", "ends", "of", "the", "tibia", "and", "femur", ".", "In", "tuberculosis", ",", "osteomyelitis", "is", "predominantly", "located", "in", "the", "vertebral", "bodies", ".", "In", "rare", "cases", "osteomyelitis", "can", "be", "caused", "by", "viruses", ",", "fungi", "or", "echinococcus", ".", "It", "may", "also", "occur", "as", "so", "-", "called", "acute", "endogenic", "osteomyelitis", ",", "such", "as", "plasmocellular", "osteomyelitis", "and", "Brodie", "'s", "abscess", ".", "Histologically", ",", "dense", "infiltration", "of", "leucocytes", ",", "granulation", "tissue", "and", "bone", "sequesters", "can", "be", "seen", ".", "In", "tuberculosis", "granulomas", "with", "central", "necrosis", ",", "epithelioid", "cells", "and", "giant", "cells", "of", "Langhans", "type", "are", "characteristically", "found", ".", "Most", "forms", "of", "acute", "osteomyelitis", "can", "be", "successfully", "treated", "with", "antibiotics", ",", "leading", "to", "complete", "healing", "without", "complications", ".", "Only", "a", "few", "reported", "cases", "develop", "into", "a", "secondary", ",", "chronic", "form", "." ]	[ "umlsterm" ]
Osteomyelitis, infection, bone marrow, osteomyelitis, form, Mycobacterium tuberculosis, infection, form, children, adults, tibia, femur, tuberculosis, osteomyelitis, osteomyelitis, viruses, fungi, echinococcus, osteomyelitis, osteomyelitis, abscess, leucocytes, granulation tissue, bone, tuberculosis, granulomas, necrosis, epithelioid cells, giant cells, forms, osteomyelitis, antibiotics, complications, secondary, form	DerRadiologe.60360781.eng.abstr_task2	Sentence: Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O" ]	Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form .	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sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, malignidad is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA	539_task0	Sentence: Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo. 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"O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo.	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sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, malignidad is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA	539_task1	Sentence: Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo. 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"O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo.	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sinovitis villonodular pigmentada, malignidad, sinovitis villonodular pigmentada, sinovitis villonodular pigmentada, sinovitis villonodular pigmentada	539_task2	Sentence: Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo. 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"O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo.	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"sugestivo", "de", "buena", "respuesta", "al", "tratamiento", ".", "\n", "En", "la", "resonancia", "magnética", "de", "abril", "de", "2018", "no", "se", "aprecian", "cambios", "significativos", "respecto", "a", "los", "estudios", "previos", ",", "lo", "cual", "indica", "que", "existe", "una", "estabilización", "de", "la", "enfermedad", ".", "\n", "En", "la", "última", "resonancia", "magnética", ",", "realizada", "en", "marzo", "de", "2019", "se", "observan", "áreas", "de", "engrosamiento", "sinovial", "con", "depósitos", "de", "hemosiderina", "que", "no", "han", "variado", "respecto", "al", "último", "estudio", ".", "Se", "aprecia", "área", "de", "edema", "medular", "óseo", "subcondral", "en", "cóndilo", "femoral", "interno", "acorde", "con", "fractura", "de", "estrés", "en", "zona", "de", "carga", ".", "\n", "En", "cuanto", "a", "estudios", "analíticos", ",", "se", "han", "realizado", "a", "lo", "largo", "del", "seguimiento", "en", "consultas", "de", "Oncología", "sucesivos", "controles", "que", "incluían", "bioquímica", "básica", ",", "perfil", "tiroideo", ",", "perfil", "hepático", "y", "hemograma", ".", "\n", "Únicamente", "cabe", "destacar", "una", "elevación", "de", "transaminasas", "(", "GOT", "89", "UI", "/", "l", "y", "GGT", "de", "113", "UI", "/", "l", ")", ",", "sin", "elevación", "de", "bilirrubina", "total", "ni", "directa", ",", "en", "noviembre", "de", "2017", ".", "El", "resto", "de", "las", "determinaciones", "analíticas", "no", "ha", "mostrado", "alteraciones", "durante", "el", "seguimiento", ".", "\n\n", "Diagnóstico", "\n", "El", "diagnóstico", "de", "la", "enfermedad", "se", "lleva", "a", "cabo", "mediante", "pruebas", "de", "imagen", "que", "permitan", "estudiar", "de", "manera", "detallada", "los", "tejidos", "blandos", ",", "por", "lo", "que", "se", "recomienda", "la", "resonancia", "magnética", ".", "Además", ",", "se", "debe", "completar", "el", "estudio", "con", "pruebas", "histológicas", "que", "confirmen", "el", "diagnóstico", ".", "\n", "En", "nuestro", "caso", ",", "las", "pruebas", "diagnósticas", "que", "confirmaron", "el", "diagnóstico", "fueron", ":", "\n", "»", "Artroscopia", "diagnóstica", "en", "2013", "a", "partir", "de", "la", "cual", "se", "obtuvo", "el", "siguiente", "resultado", "anatomopatológico", ":", "proliferación", "papilar", "de", "revestimiento", "sinovial", "por", "debajo", "de", "la", "cual", "se", "observa", "una", "proliferación", "de", "histiocitos", "y", "células", "gigantes", "multinucleadas", ",", "alternando", "con", "fagocitos", "que", "contienen", "hemosiderina", ".", "\n", "»", "La", "prueba", "de", "imagen", "realizada", "en", "el", "año", "2012", "(", "RM", ")", "no", "confirmaba", "el", "diagnóstico", ",", "sino", "que", "orientaba", "a", "una", "sinovitis", "crónica", ".", "No", "fue", "hasta", "2017", "cuando", "en", "una", "nueva", "RM", "se", "observó", "enfermedad", "sinovial", "difusa", "con", "derrame", "articular", "y", "engrosamiento", "de", "la", "sinovial", ",", "con", "depósitos", "de", "hemosiderina", ",", "todo", "ello", "compatible", "con", "el", "diagnóstico", "de", "sinovitis", "villonodular", "pigmentada", ".", "\n\n", "Tratamiento", "\n", "Desde", "el", "inicio", "del", "cuadro", ",", "el", "paciente", "ha", "requerido", "tratamiento", "analgésico", ",", "por", "lo", "general", "con", "AINE", "(", "dexketoprofeno", ")", ",", "con", "control", "parcial", "del", "dolor", ",", "pero", "sin", "haber", "tenido", "necesidad", "de", "hacer", "uso", "de", "analgésicos", "de", "segundo", "o", "tercer", "escalón", "según", "escala", "de", "la", "Organización", "Mundial", "de", "la", "Salud", "(", "OMS", ")", "ni", "de", "otros", "coadyuvantes", ".", "\n", "Además", ",", "el", "paciente", "ha", "recibido", "corticoides", "(", "metilprednisolona", ")", "vía", "oral", "para", "reducir", "la", "inflamación", "articular", ".", "\n", "En", "abril", "de", "2017", ",", "el", "paciente", "inició", "tratamiento", "con", "imatinib", "mesilato", "a", "dosis", "de", "400", "mg", "al", "día", "vía", "oral", ".", "Tras", "presentar", "aftas", "bucales", "y", "mucositis", "grado", "2", ",", "se", "decidió", "reducir", "la", "dosis", "de", "imatinib", "a", "300", "mg", "al", "día", "vía", "oral", "con", "buena", "tolerancia", "sin", "necesidad", "de", "nuevas", "reducciones", "de", "dosis", ".", "\n\n", "Evolución", "\n", "En", "resonancia", "magnética", "realizada", "en", "junio", "de", "2017", ",", "se", "apreció", "una", "respuesta", "parcial", "de", "la", "enfermedad", ".", "\n", "Tras", "dos", "meses", "de", "tratamiento", ",", "el", "paciente", "presentó", "aftas", "bucales", "dolorosas", ",", "por", "lo", "que", "se", "decidió", "reducir", "la", "dosis", "de", "imatinib", "a", "300", "mg", "diarios", ".", "\n", "En", "resonancia", "magnética", "de", "noviembre", "de", "2017", "se", "aprecia", "clara", "mejoría", "radiológica", ",", "con", "marcada", "reducción", "del", "derrame", "articular", ",", "del", "tamaño", "del", "paño", "sinovítico", "(", "sobre", "todo", "en", "zona", "infrapatelar", ")", "y", "reducción", "del", "grado", "de", "realce", ".", "\n", "En", "el", "mismo", "mes", ",", "tras", "solicitud", "de", "análisis", "de", "control", "se", "apreció", "una", "elevación", "de", "transaminasas", "con", "GOT", "de", "89", "UI", "/", "l", "y", "GPT", "de", "113", "UI", "/", "l", ",", "permaneciendo", "el", "paciente", "asintomático", ".", "No", "se", "detectó", "elevación", "de", "bilirrubina", ".", "Se", "decidió", "continuar", "con", "la", "misma", "pauta", "de", "imatinib", "y", "realizar", "controles", "analíticos", "periódicos", "observando", "a", "las", "tres", "semanas", "una", "normalización", "de", "las", "cifras", "de", "transaminasas", ".", "\n", "El", "paciente", "actualmente", "refiere", "una", "clara", "mejoría", "clínica", "y", "en", "las", "pruebas", "radiológicas", "es", "evidente", "una", "buena", "respuesta", "al", "tratamiento", ".", "A", "pesar", "de", "ello", ",", "el", "paciente", "no", "ha", "podido", "reanudar", "la", "actividad", "que", "realizaba", "previamente", ",", "puesto", "que", ",", "en", "la", "resonancia", "magnética", "de", "marzo", "de", "2019", ",", "se", "observa", "la", "presencia", "de", "pequeña", "fractura", "de", "estrés", "y", "edema", "en", "cóndilo", "interno", "de", "fémur", "en", "zona", "de", "carga", ",", "por", "lo", "que", "se", "le", "recomienda", "reposo", "relativo", "." ]	[ "MORFOLOGIA_NEOPLASIA" ]
Callus is an umlsterm, treatment is an umlsterm, May is an umlsterm, patients is an umlsterm, osteotomy is an umlsterm, haloborne is an umlsterm, patients is an umlsterm, patients is an umlsterm, edentulous is an umlsterm, upper jaw is an umlsterm, velopharyngeal insufficiency is an umlsterm, patient is an umlsterm, patients is an umlsterm, pain is an umlsterm, soft palate is an umlsterm, Follow - up studies is an umlsterm, edentulous is an umlsterm, patients is an umlsterm, Callus is an umlsterm, surgery is an umlsterm	MundKieferGesichtschirurgie.0004s442.eng.abstr_task0	Sentence: Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases .	[ "Callus", "distraction", "in", "the", "treatment", "of", "severe", "midfacial", "hypoplasia", "/", "atrophy", "may", "offer", "new", "therapeutical", "possibilities", ".", "Between", "May", "1998", "and", "March", "1999", ",", "six", "patients", "underwent", "a", "subtotal", "Le", "Fort", "I", "-", "II", "osteotomy", "with", "subsequent", "distraction", "via", "a", "haloborne", "distractor", "(", "RED", ")", ".", "Five", "patients", "suffered", "from", "CLP", ",", "four", "patients", "were", "totally", "or", "almost", "edentulous", "in", "the", "upper", "jaw", ".", "Corrections", "of", "sagittal", "discrepancies", "were", "possible", "in", "all", "cases", "(", "distraction", "16", "-", "31", "mm", ")", ".", "No", "case", "of", "increased", "velopharyngeal", "insufficiency", "was", "seen", ".", "In", "one", "patient", "the", "halo", "had", "to", "be", "refixed", ".", "Three", "patients", "suffered", "from", "tension", "-", "like", "pain", "in", "the", "soft", "palate", "during", "distraction", ".", "Follow", "-", "up", "studies", "suggest", "the", "necessity", "for", "overcorrection", "of", "20", "%", "in", "edentulous", "senior", "patients", ".", "Callus", "midfacial", "distraction", "is", "a", "promising", "new", "alternative", "to", "conventional", "orthognathic", "surgery", "in", "severe", "cases", "." ]	[ "umlsterm" ]
Callus is an umlsterm, treatment is an umlsterm, May is an umlsterm, patients is an umlsterm, osteotomy is an umlsterm, haloborne is an umlsterm, patients is an umlsterm, patients is an umlsterm, edentulous is an umlsterm, upper jaw is an umlsterm, velopharyngeal insufficiency is an umlsterm, patient is an umlsterm, patients is an umlsterm, pain is an umlsterm, soft palate is an umlsterm, Follow - up studies is an umlsterm, edentulous is an umlsterm, patients is an umlsterm, Callus is an umlsterm, surgery is an umlsterm	MundKieferGesichtschirurgie.0004s442.eng.abstr_task1	Sentence: Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases . Instructions: please typing these entity words according to sentence: Callus, treatment, May, patients, osteotomy, haloborne, patients, patients, edentulous, upper jaw, velopharyngeal insufficiency, patient, patients, pain, soft palate, Follow - up studies, edentulous, patients, Callus, surgery Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases .	[ "Callus", "distraction", "in", "the", "treatment", "of", "severe", "midfacial", "hypoplasia", "/", "atrophy", "may", "offer", "new", "therapeutical", "possibilities", ".", "Between", "May", "1998", "and", "March", "1999", ",", "six", "patients", "underwent", "a", "subtotal", "Le", "Fort", "I", "-", "II", "osteotomy", "with", "subsequent", "distraction", "via", "a", "haloborne", "distractor", "(", "RED", ")", ".", "Five", "patients", "suffered", "from", "CLP", ",", "four", "patients", "were", "totally", "or", "almost", "edentulous", "in", "the", "upper", "jaw", ".", "Corrections", "of", "sagittal", "discrepancies", "were", "possible", "in", "all", "cases", "(", "distraction", "16", "-", "31", "mm", ")", ".", "No", "case", "of", "increased", "velopharyngeal", "insufficiency", "was", "seen", ".", "In", "one", "patient", "the", "halo", "had", "to", "be", "refixed", ".", "Three", "patients", "suffered", "from", "tension", "-", "like", "pain", "in", "the", "soft", "palate", "during", "distraction", ".", "Follow", "-", "up", "studies", "suggest", "the", "necessity", "for", "overcorrection", "of", "20", "%", "in", "edentulous", "senior", "patients", ".", "Callus", "midfacial", "distraction", "is", "a", "promising", "new", "alternative", "to", "conventional", "orthognathic", "surgery", "in", "severe", "cases", "." ]	[ "umlsterm" ]
Callus, treatment, May, patients, osteotomy, haloborne, patients, patients, edentulous, upper jaw, velopharyngeal insufficiency, patient, patients, pain, soft palate, Follow - up studies, edentulous, patients, Callus, surgery	MundKieferGesichtschirurgie.0004s442.eng.abstr_task2	Sentence: Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases .	[ "Callus", "distraction", "in", "the", "treatment", "of", "severe", "midfacial", "hypoplasia", "/", "atrophy", "may", "offer", "new", "therapeutical", "possibilities", ".", "Between", "May", "1998", "and", "March", "1999", ",", "six", "patients", "underwent", "a", "subtotal", "Le", "Fort", "I", "-", "II", "osteotomy", "with", "subsequent", "distraction", "via", "a", "haloborne", "distractor", "(", "RED", ")", ".", "Five", "patients", "suffered", "from", "CLP", ",", "four", "patients", "were", "totally", "or", "almost", "edentulous", "in", "the", "upper", "jaw", ".", "Corrections", "of", "sagittal", "discrepancies", "were", "possible", "in", "all", "cases", "(", "distraction", "16", "-", "31", "mm", ")", ".", "No", "case", "of", "increased", "velopharyngeal", "insufficiency", "was", "seen", ".", "In", "one", "patient", "the", "halo", "had", "to", "be", "refixed", ".", "Three", "patients", "suffered", "from", "tension", "-", "like", "pain", "in", "the", "soft", "palate", "during", "distraction", ".", "Follow", "-", "up", "studies", "suggest", "the", "necessity", "for", "overcorrection", "of", "20", "%", "in", "edentulous", "senior", "patients", ".", "Callus", "midfacial", "distraction", "is", "a", "promising", "new", "alternative", "to", "conventional", "orthognathic", "surgery", "in", "severe", "cases", "." ]	[ "umlsterm" ]
aspartate is a Entity, coagulation factors IX is a Protein, EGF - like modules is a Entity, coagulation factors IX is a Protein, X is a Protein, factor X is a Protein, factor IX is a Protein, factor X is a Protein, factor IX is a Protein	548_task0	Sentence: The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding.	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aspartate is a Entity, coagulation factors IX is a Protein, EGF - like modules is a Entity, coagulation factors IX is a Protein, X is a Protein, factor X is a Protein, factor IX is a Protein, factor X is a Protein, factor IX is a Protein	548_task1	Sentence: The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding. Instructions: please typing these entity words according to sentence: aspartate, coagulation factors IX, EGF - like modules, coagulation factors IX, X, factor X, factor IX, factor X, factor IX Options: Entity, Protein	[ "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding.	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aspartate, coagulation factors IX, EGF - like modules, coagulation factors IX, X, factor X, factor IX, factor X, factor IX	548_task2	Sentence: The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding.	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Patienten is an umlsterm, Operationsmethode is an umlsterm, Rezidivleisten- is an umlsterm, Rezidivraten is an umlsterm, Rezidivoperationen is an umlsterm, Operationsmorbiditaet is an umlsterm, Langzeitkomplikationen is an umlsterm, Patienten is an umlsterm, Arbeitsplatz is an umlsterm	DerChirurg.70680970.ger.abstr_task0	Sentence: Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren .	[ "Zusammenfassung", ".", "Eine", "8", "jaehrige", "Erfahrung", "(", "1989", "-", "1996", ")", "an", "ueber", "3.000", "Patienten", "laesst", "erkennen", ",", "dass", "die", "PerFix", "-", "Netzplomben", "-", "Hernioplastik", "eine", "einfache", "Operationsmethode", "darstellt", "und", "in", "standardisierter", "Form", "eingesetzt", "werden", "kann", ",", "um", "praktisch", "alle", "primaeren", "oder", "Rezidivleisten-", "oder", "Femoralhernien", "zu", "behandeln", ".", "Die", "Rezidivraten", "bleiben", "annehmbar", "niedrig", "(", "1", "%", "bei", "primaeren", "und", "2", "%", "bei", "Rezidivoperationen", ")", "und", ",", "was", "am", "wichtigsten", "ist", ",", "die", "Operationsmorbiditaet", "und", "die", "Kurz-", "und", "Langzeitkomplikationen", "werden", "im", "wesentlichen", "vermieden", ".", "Als", "unmittelbare", "Folge", "sind", "die", "Patienten", "sofort", "in", "der", "Lage", ",", "ihre", "normalen", "taeglichen", "Aktivitaeten", "wiederaufzunehmen", "und", "rasch", "an", "ihren", "Arbeitsplatz", "zurueckzukehren", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Operationsmethode is an umlsterm, Rezidivleisten- is an umlsterm, Rezidivraten is an umlsterm, Rezidivoperationen is an umlsterm, Operationsmorbiditaet is an umlsterm, Langzeitkomplikationen is an umlsterm, Patienten is an umlsterm, Arbeitsplatz is an umlsterm	DerChirurg.70680970.ger.abstr_task1	Sentence: Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren . Instructions: please typing these entity words according to sentence: Patienten, Operationsmethode, Rezidivleisten-, Rezidivraten, Rezidivoperationen, Operationsmorbiditaet, Langzeitkomplikationen, Patienten, Arbeitsplatz Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren .	[ "Zusammenfassung", ".", "Eine", "8", "jaehrige", "Erfahrung", "(", "1989", "-", "1996", ")", "an", "ueber", "3.000", "Patienten", "laesst", "erkennen", ",", "dass", "die", "PerFix", "-", "Netzplomben", "-", "Hernioplastik", "eine", "einfache", "Operationsmethode", "darstellt", "und", "in", "standardisierter", "Form", "eingesetzt", "werden", "kann", ",", "um", "praktisch", "alle", "primaeren", "oder", "Rezidivleisten-", "oder", "Femoralhernien", "zu", "behandeln", ".", "Die", "Rezidivraten", "bleiben", "annehmbar", "niedrig", "(", "1", "%", "bei", "primaeren", "und", "2", "%", "bei", "Rezidivoperationen", ")", "und", ",", "was", "am", "wichtigsten", "ist", ",", "die", "Operationsmorbiditaet", "und", "die", "Kurz-", "und", "Langzeitkomplikationen", "werden", "im", "wesentlichen", "vermieden", ".", "Als", "unmittelbare", "Folge", "sind", "die", "Patienten", "sofort", "in", "der", "Lage", ",", "ihre", "normalen", "taeglichen", "Aktivitaeten", "wiederaufzunehmen", "und", "rasch", "an", "ihren", "Arbeitsplatz", "zurueckzukehren", "." ]	[ "umlsterm" ]
Patienten, Operationsmethode, Rezidivleisten-, Rezidivraten, Rezidivoperationen, Operationsmorbiditaet, Langzeitkomplikationen, Patienten, Arbeitsplatz	DerChirurg.70680970.ger.abstr_task2	Sentence: Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren .	[ "Zusammenfassung", ".", "Eine", "8", "jaehrige", "Erfahrung", "(", "1989", "-", "1996", ")", "an", "ueber", "3.000", "Patienten", "laesst", "erkennen", ",", "dass", "die", "PerFix", "-", "Netzplomben", "-", "Hernioplastik", "eine", "einfache", "Operationsmethode", "darstellt", "und", "in", "standardisierter", "Form", "eingesetzt", "werden", "kann", ",", "um", "praktisch", "alle", "primaeren", "oder", "Rezidivleisten-", "oder", "Femoralhernien", "zu", "behandeln", ".", "Die", "Rezidivraten", "bleiben", "annehmbar", "niedrig", "(", "1", "%", "bei", "primaeren", "und", "2", "%", "bei", "Rezidivoperationen", ")", "und", ",", "was", "am", "wichtigsten", "ist", ",", "die", "Operationsmorbiditaet", "und", "die", "Kurz-", "und", "Langzeitkomplikationen", "werden", "im", "wesentlichen", "vermieden", ".", "Als", "unmittelbare", "Folge", "sind", "die", "Patienten", "sofort", "in", "der", "Lage", ",", "ihre", "normalen", "taeglichen", "Aktivitaeten", "wiederaufzunehmen", "und", "rasch", "an", "ihren", "Arbeitsplatz", "zurueckzukehren", "." ]	[ "umlsterm" ]
muscle is a Organ, muscle is a Organ, breast muscle is a Organ, breast muscle is a Organ, muscle is a Organ, sarcomere is a Tissue, sarcomere is a Tissue, sarcomere is a Tissue	PMID-2704697_task0	Sentence: Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Tissue, Organ	[ "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "I-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "I-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development.	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muscle is a Organ, muscle is a Organ, breast muscle is a Organ, breast muscle is a Organ, muscle is a Organ, sarcomere is a Tissue, sarcomere is a Tissue, sarcomere is a Tissue	PMID-2704697_task1	Sentence: Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development. Instructions: please typing these entity words according to sentence: muscle, muscle, breast muscle, breast muscle, muscle, sarcomere, sarcomere, sarcomere Options: Tissue, Organ	[ "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "I-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "I-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development.	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muscle, muscle, breast muscle, breast muscle, muscle, sarcomere, sarcomere, sarcomere	PMID-2704697_task2	Sentence: Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "I-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "I-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Organ", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development.	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carcinoma ductal infiltrante de mama derecha de 3,7 cm , grado histológico II de Nottingham is a MORFOLOGIA_NEOPLASIA, metástasis is a MORFOLOGIA_NEOPLASIA, progresión hepática is a MORFOLOGIA_NEOPLASIA, progresión ósea is a MORFOLOGIA_NEOPLASIA, lesión única de 1 cm en hemisferio is a MORFOLOGIA_NEOPLASIA, lesión cerebelosa is a MORFOLOGIA_NEOPLASIA	365_task0	Sentence: Anamnesis Mujer de 57 años, posmenopáusica, fumadora de 20 cigarrillos/día, sin otros antecedentes personales ni familiares de interés, diagnosticada en Febrero 2012 mediante programa de cribado de un carcinoma ductal infiltrante de mama derecha de 3,7 cm, grado histológico II de Nottingham, RE +++, RP -, HER2 1+, Ki-67 17%. En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas. 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En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas.	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carcinoma ductal infiltrante de mama derecha de 3,7 cm , grado histológico II de Nottingham is a MORFOLOGIA_NEOPLASIA, metástasis is a MORFOLOGIA_NEOPLASIA, progresión hepática is a MORFOLOGIA_NEOPLASIA, progresión ósea is a MORFOLOGIA_NEOPLASIA, lesión única de 1 cm en hemisferio is a MORFOLOGIA_NEOPLASIA, lesión cerebelosa is a MORFOLOGIA_NEOPLASIA	365_task1	Sentence: Anamnesis Mujer de 57 años, posmenopáusica, fumadora de 20 cigarrillos/día, sin otros antecedentes personales ni familiares de interés, diagnosticada en Febrero 2012 mediante programa de cribado de un carcinoma ductal infiltrante de mama derecha de 3,7 cm, grado histológico II de Nottingham, RE +++, RP -, HER2 1+, Ki-67 17%. En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas. 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En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas.	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carcinoma ductal infiltrante de mama derecha de 3,7 cm , grado histológico II de Nottingham, metástasis, progresión hepática, progresión ósea, lesión única de 1 cm en hemisferio, lesión cerebelosa	365_task2	Sentence: Anamnesis Mujer de 57 años, posmenopáusica, fumadora de 20 cigarrillos/día, sin otros antecedentes personales ni familiares de interés, diagnosticada en Febrero 2012 mediante programa de cribado de un carcinoma ductal infiltrante de mama derecha de 3,7 cm, grado histológico II de Nottingham, RE +++, RP -, HER2 1+, Ki-67 17%. En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas. 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En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas.	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combination of bezafibrate and guar is a Intervention_Pharmacological, effect is a Outcome_Physical, a dietary fibre is a Intervention_Pharmacological, 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . is a Participant_Condition, Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross - over study for 3 months is a Intervention_Pharmacological, Guar is a Intervention_Pharmacological, total cholesterol is a Outcome_Physical, low density lipoprotein cholesterol ( LDL - cholesterol is a Outcome_Physical, apoprotein B is a Outcome_Physical, plasma triglyceride level and the triglyceride distribution is a Outcome_Physical, fasting plasma glucose level nor the body weight is a Outcome_Physical, guar treatment is a Intervention_Pharmacological, slight nausea , meteorism and constipation is a Outcome_Adverse-effects, bezafibrate . is a Intervention_Pharmacological	80499_task0	Sentence: Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition, Outcome_Adverse-effects	[ "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological" ]	Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate .	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combination of bezafibrate and guar is a Intervention_Pharmacological, effect is a Outcome_Physical, a dietary fibre is a Intervention_Pharmacological, 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . is a Participant_Condition, Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross - over study for 3 months is a Intervention_Pharmacological, Guar is a Intervention_Pharmacological, total cholesterol is a Outcome_Physical, low density lipoprotein cholesterol ( LDL - cholesterol is a Outcome_Physical, apoprotein B is a Outcome_Physical, plasma triglyceride level and the triglyceride distribution is a Outcome_Physical, fasting plasma glucose level nor the body weight is a Outcome_Physical, guar treatment is a Intervention_Pharmacological, slight nausea , meteorism and constipation is a Outcome_Adverse-effects, bezafibrate . is a Intervention_Pharmacological	80499_task1	Sentence: Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate . Instructions: please typing these entity words according to sentence: combination of bezafibrate and guar, effect, a dietary fibre, 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) ., Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross - over study for 3 months, Guar, total cholesterol, low density lipoprotein cholesterol ( LDL - cholesterol, apoprotein B, plasma triglyceride level and the triglyceride distribution, fasting plasma glucose level nor the body weight, guar treatment, slight nausea , meteorism and constipation, bezafibrate . Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition, Outcome_Adverse-effects	[ "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological" ]	Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate .	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combination of bezafibrate and guar, effect, a dietary fibre, 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) ., Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross - over study for 3 months, Guar, total cholesterol, low density lipoprotein cholesterol ( LDL - cholesterol, apoprotein B, plasma triglyceride level and the triglyceride distribution, fasting plasma glucose level nor the body weight, guar treatment, slight nausea , meteorism and constipation, bezafibrate .	80499_task2	Sentence: Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological" ]	Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate .	[ "Treatment", "of", "familial", "hypercholesterolemia", "with", "a", "combination", "of", "bezafibrate", "and", "guar", ".", "The", "effect", "of", "guar", "(", "15.6", "g", "/", "day", ")", ",", "a", "dietary", "fibre", ",", "and", "simultaneous", "administration", "of", "bezafibrate", "(", "600", "mg", "/", "day", ")", "during", "dietetic", "treatment", "on", "the", "plasma", "lipoproteins", "and", "apolipoproteins", "was", "investigated", "in", "12", "patients", "with", "familial", "hypercholesterolemia", "(", "corresponding", "to", "the", "HLP", "type", "IIa", "pattern", ")", ".", "Either", "bezafibrate", "alone", "or", "bezafibrate", "in", "combination", "with", "guar", "was", "administered", "in", "a", "cross", "-", "over", "study", "for", "3", "months", ".", "Guar", "led", "to", "an", "additional", "lowering", "of", "the", "total", "cholesterol", "in", "the", "plasma", "by", "7", "%", "(", "P", "less", "than", "or", "equal", "to", "0.05", ")", "associated", "with", "a", "fall", "of", "the", "low", "density", "lipoprotein", "cholesterol", "(", "LDL", "-", "cholesterol", "(", "LDL", "-", "cholesterol", ")", "by", "13", "%", "(", "P", "less", "than", "or", "equal", "to", "0.01", ")", "without", "any", "changes", "in", "the", "very", "low", "density", "lipoprotein", "(", "VLDL", ")", "and", "high", "density", "lipoprotein", "(", "HDL", ")", "cholesterols", ".", "In", "parallel", "with", "the", "decrease", "in", "LDL", "-", "cholesterol", ",", "the", "apoprotein", "B", "also", "was", "diminished", "by", "20", "%", "(", "P", "less", "than", "or", "equal", "to", "0.05", ")", ".", "The", "plasma", "triglyceride", "level", "and", "the", "triglyceride", "distribution", "within", "the", "individual", "lipoprotein", "fractions", "were", "not", "altered", "in", "any", "consistent", "manner", "by", "the", "addition", "of", "guar", ".", "Neither", "the", "fasting", "plasma", "glucose", "level", "nor", "the", "body", "weight", "were", "affected", ".", "The", "side", "-", "effects", "due", "to", "guar", "treatment", "consisted", "of", "slight", "nausea", ",", "meteorism", "and", "constipation", ",", "but", "this", "did", "not", "in", "any", "of", "the", "cases", "lead", "to", "early", "termination", "of", "the", "study", ".", "These", "results", "demonstrate", "that", "guar", "exerts", "its", "cholesterol", "-", "lowering", "effect", "in", "addition", "to", "that", "of", "bezafibrate", "." ]	[ "Intervention_Pharmacological", "Participant_Condition", "Outcome_Physical", "Outcome_Adverse-effects" ]
nativradiologisch is an umlsterm, Unfallmechanismus is an umlsterm, Therapie is an umlsterm, Dislokationen is an umlsterm, Klassifikation is an umlsterm, Frakturen is an umlsterm, Korrekturosteotomie is an umlsterm, Klassifikation is an umlsterm	DerUnfallchirurg.01030791.ger.abstr_task0	Sentence: Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen .	[ "Undislozierte", "Densbasisfrakturen", "koennen", "nativradiologisch", "ohne", "Beruecksichtigung", "des", "zugrundeliegenden", "Unfallmechanismus", "eine", "Stabilitaet", "vortaeuschen", ",", "die", "bei", "konservativer", "Therapie", "zu", "sekundaeren", "Dislokationen", "fuehren", "koennen", ".", "Dies", "wird", "vor", "allem", "bei", "der", "Klassifikation", "der", "Dens", "Frakturen", "nach", "Anderson", "und", "D", "'", "Alonzo", "leicht", "uebersehen", ".", "Anhand", "einer", "Kasuistik", "wird", "diese", "Problematik", "aufgezeigt", ",", "der", "operative", "Anspruch", "einer", "vermeidbaren", ",", "risikoreichen", "transoralen", "Korrekturosteotomie", "dargelegt", "und", "auf", "eine", "aussagekraeftigere", "Klassifikation", "der", "Densfrakturen", "verwiesen", "." ]	[ "umlsterm" ]
nativradiologisch is an umlsterm, Unfallmechanismus is an umlsterm, Therapie is an umlsterm, Dislokationen is an umlsterm, Klassifikation is an umlsterm, Frakturen is an umlsterm, Korrekturosteotomie is an umlsterm, Klassifikation is an umlsterm	DerUnfallchirurg.01030791.ger.abstr_task1	Sentence: Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen . Instructions: please typing these entity words according to sentence: nativradiologisch, Unfallmechanismus, Therapie, Dislokationen, Klassifikation, Frakturen, Korrekturosteotomie, Klassifikation Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen .	[ "Undislozierte", "Densbasisfrakturen", "koennen", "nativradiologisch", "ohne", "Beruecksichtigung", "des", "zugrundeliegenden", "Unfallmechanismus", "eine", "Stabilitaet", "vortaeuschen", ",", "die", "bei", "konservativer", "Therapie", "zu", "sekundaeren", "Dislokationen", "fuehren", "koennen", ".", "Dies", "wird", "vor", "allem", "bei", "der", "Klassifikation", "der", "Dens", "Frakturen", "nach", "Anderson", "und", "D", "'", "Alonzo", "leicht", "uebersehen", ".", "Anhand", "einer", "Kasuistik", "wird", "diese", "Problematik", "aufgezeigt", ",", "der", "operative", "Anspruch", "einer", "vermeidbaren", ",", "risikoreichen", "transoralen", "Korrekturosteotomie", "dargelegt", "und", "auf", "eine", "aussagekraeftigere", "Klassifikation", "der", "Densfrakturen", "verwiesen", "." ]	[ "umlsterm" ]
nativradiologisch, Unfallmechanismus, Therapie, Dislokationen, Klassifikation, Frakturen, Korrekturosteotomie, Klassifikation	DerUnfallchirurg.01030791.ger.abstr_task2	Sentence: Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen .	[ "Undislozierte", "Densbasisfrakturen", "koennen", "nativradiologisch", "ohne", "Beruecksichtigung", "des", "zugrundeliegenden", "Unfallmechanismus", "eine", "Stabilitaet", "vortaeuschen", ",", "die", "bei", "konservativer", "Therapie", "zu", "sekundaeren", "Dislokationen", "fuehren", "koennen", ".", "Dies", "wird", "vor", "allem", "bei", "der", "Klassifikation", "der", "Dens", "Frakturen", "nach", "Anderson", "und", "D", "'", "Alonzo", "leicht", "uebersehen", ".", "Anhand", "einer", "Kasuistik", "wird", "diese", "Problematik", "aufgezeigt", ",", "der", "operative", "Anspruch", "einer", "vermeidbaren", ",", "risikoreichen", "transoralen", "Korrekturosteotomie", "dargelegt", "und", "auf", "eine", "aussagekraeftigere", "Klassifikation", "der", "Densfrakturen", "verwiesen", "." ]	[ "umlsterm" ]
bone fracture is an umlsterm, patients is an umlsterm, radius is an umlsterm, Germany is an umlsterm, geriatric is an umlsterm, fractures is an umlsterm, hip is an umlsterm, treatment is an umlsterm, older is an umlsterm, patients is an umlsterm, osteoporosis is an umlsterm, fracture is an umlsterm, secondary is an umlsterm, comminuted is an umlsterm, bone is an umlsterm, perception is an umlsterm, tissue is an umlsterm, need is an umlsterm, bone graft is an umlsterm, surgical is an umlsterm, literature review is an umlsterm, radius fractures is an umlsterm, patients is an umlsterm, older is an umlsterm, procedure is an umlsterm, fractures is an umlsterm, radius is an umlsterm, joint is an umlsterm, immobilisation is an umlsterm, complication is an umlsterm, radius fracture is an umlsterm, treatment is an umlsterm, older is an umlsterm, patients is an umlsterm, patients is an umlsterm, risk is an umlsterm, attention is an umlsterm, nerves is an umlsterm, pins is an umlsterm, signs is an umlsterm, complications is an umlsterm, patients is an umlsterm, older is an umlsterm, fracture is an umlsterm, radius is an umlsterm, follow up study is an umlsterm, radius fractures is an umlsterm, classification is an umlsterm, measures is an umlsterm, bone is an umlsterm, bone graft is an umlsterm, times is an umlsterm, disease is an umlsterm, complications is an umlsterm, treatment is an umlsterm, radial nerve is an umlsterm, surgical is an umlsterm, pin is an umlsterm, joints is an umlsterm, patients is an umlsterm, fracture is an umlsterm, patients is an umlsterm, fracture is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm, older is an umlsterm, patients is an umlsterm	DerOrthopaede.00290318.eng.abstr_task0	Sentence: Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]	Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients .	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bone fracture is an umlsterm, patients is an umlsterm, radius is an umlsterm, Germany is an umlsterm, geriatric is an umlsterm, fractures is an umlsterm, hip is an umlsterm, treatment is an umlsterm, older is an umlsterm, patients is an umlsterm, osteoporosis is an umlsterm, fracture is an umlsterm, secondary is an umlsterm, comminuted is an umlsterm, bone is an umlsterm, perception is an umlsterm, tissue is an umlsterm, need is an umlsterm, bone graft is an umlsterm, surgical is an umlsterm, literature review is an umlsterm, radius fractures is an umlsterm, patients is an umlsterm, older is an umlsterm, procedure is an umlsterm, fractures is an umlsterm, radius is an umlsterm, joint is an umlsterm, immobilisation is an umlsterm, complication is an umlsterm, radius fracture is an umlsterm, treatment is an umlsterm, older is an umlsterm, patients is an umlsterm, patients is an umlsterm, risk is an umlsterm, attention is an umlsterm, nerves is an umlsterm, pins is an umlsterm, signs is an umlsterm, complications is an umlsterm, patients is an umlsterm, older is an umlsterm, fracture is an umlsterm, radius is an umlsterm, follow up study is an umlsterm, radius fractures is an umlsterm, classification is an umlsterm, measures is an umlsterm, bone is an umlsterm, bone graft is an umlsterm, times is an umlsterm, disease is an umlsterm, complications is an umlsterm, treatment is an umlsterm, radial nerve is an umlsterm, surgical is an umlsterm, pin is an umlsterm, joints is an umlsterm, patients is an umlsterm, fracture is an umlsterm, patients is an umlsterm, fracture is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm, older is an umlsterm, patients is an umlsterm	DerOrthopaede.00290318.eng.abstr_task1	Sentence: Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients . Instructions: please typing these entity words according to sentence: bone fracture, patients, radius, Germany, geriatric, fractures, hip, treatment, older, patients, osteoporosis, fracture, secondary, comminuted, bone, perception, tissue, need, bone graft, surgical, literature review, radius fractures, patients, older, procedure, fractures, radius, joint, immobilisation, complication, radius fracture, treatment, older, patients, patients, risk, attention, nerves, pins, signs, complications, patients, older, fracture, radius, follow up study, radius fractures, classification, measures, bone, bone graft, times, disease, complications, treatment, radial nerve, surgical, pin, joints, patients, fracture, patients, fracture, treatment, radius fractures, older, patients Options: umlsterm	[ "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O" ]	Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients .	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bone fracture, patients, radius, Germany, geriatric, fractures, hip, treatment, older, patients, osteoporosis, fracture, secondary, comminuted, bone, perception, tissue, need, bone graft, surgical, literature review, radius fractures, patients, older, procedure, fractures, radius, joint, immobilisation, complication, radius fracture, treatment, older, patients, patients, risk, attention, nerves, pins, signs, complications, patients, older, fracture, radius, follow up study, radius fractures, classification, measures, bone, bone graft, times, disease, complications, treatment, radial nerve, surgical, pin, joints, patients, fracture, patients, fracture, treatment, radius fractures, older, patients	DerOrthopaede.00290318.eng.abstr_task2	Sentence: Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients . 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This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients .	[ "Every", "15th", "case", "of", "a", "bone", "fracture", "in", "patients", "aged", "more", "than", "65", "years", "concerns", "the", "distal", "radius", "in", "Germany", ".", "This", "means", "the", "second", "rank", "of", "all", "geriatric", "fractures", "following", "fractures", "of", "the", "hip", ".", "According", "to", "the", "approved", "and", "increased", "apply", "of", "operative", "stabilisation", "there", "are", "arising", "more", "and", "more", "reports", "upon", "poor", "results", "of", "nonsurgical", "treatment", ".", "Especially", "in", "older", "patients", "the", "main", "reason", "for", "the", "discontented", "outcome", "of", "conservative", "management", "is", "osteoporosis", ",", "which", "is", "an", "affirmative", "circumstance", "for", "the", "genesis", "of", "fracture", "but", "also", "for", "secondary", "malaligment", "of", "comminuted", "thin", "cortical", "walls", "and", "crushed", "porotic", "cancellous", "bone", ".", "The", "rational", "of", "this", "perception", "is", "either", "filling", "artificial", "bonelike", "tissue", "-", "avoiding", "the", "need", "of", "harvest", "cancellous", "bone", "graft", "from", "a", "second", "surgical", "site", "-", "into", "the", "resultant", "cavity", "following", "reduction", ",", "or", "supplementary", "transstyloidal", "or", "intrafocal", "K", "-", "wiring", "until", "remodeling", "is", "obtained", "within", "an", "average", "of", "10", "weeks", ".", "Both", "arrangements", "should", "be", "secured", "in", "addition", "with", "a", "transarticular", "external", "fixation", ".", "According", "to", "a", "literature", "review", "and", "our", "own", "experiences", "of", "92", "follow", "up", "cases", "of", "distal", "radius", "fractures", "in", "patients", "who", "were", "older", "than", "65", "years", "this", "procedure", "seems", "to", "be", "superior", "at", "present", "for", "A-2", ",", "A-3", "and", "most", "cases", "of", "type", "-", "C", "fractures", "of", "the", "distal", "radius", ",", "despite", "the", "disadvantage", "of", "joint", "immobilisation", "for", "about", "5", "weeks", ".", "Type", "B", "-", "fractures", ",", "however", ",", "should", "be", "provided", "better", "with", "an", "internal", "fixation", ".", "Sudeck", "'s", "algodystrophia", "is", "the", "mostly", "serious", "complication", "of", "the", "distal", "radius", "fracture", "and", "its", "treatment", "in", "older", "patients", ".", "Recognising", "punctually", "neurovegetative", "stimulated", "patients", ",", "treat", "them", "cautiously", "and", "coming", "in", "on", "their", "special", "situation", "is", "usually", "the", "best", "way", "to", "reduce", "this", "risk", ".", "To", "pay", "attention", "to", "the", "topography", "of", "the", "nerves", "during", "the", "application", "of", "the", "pins", "and", "to", "act", "at", "the", "first", "signs", "of", "complications", "immediately", "is", "also", "very", "important", ".", "We", "examined", "92", "patients", "who", "were", "older", "than", "65", "years", "with", "a", "fracture", "of", "the", "distal", "end", "of", "the", "radius", "in", "a", "follow", "up", "study", ".", "In", "this", "group", "we", "treated", "62", "distal", "radius", "fractures", "of", "the", "type", "A", "and", "C", "of", "the", "AO", "classification", "with", "an", "transarticular", "external", "fixateur", "and", "with", "supplementary", "measures", "if", "necessary", ".", "Additionally", "we", "filled", "the", "bone", "cavity", "with", "an", "artificial", "bone", "graft", "(", "Endobon", ")", "following", "closed", "reduction", "in", "32", "cases", ",", "12", "times", "a", "complementary", "K", "-", "wiring", "was", "added", "and", "in", "8", "cases", "the", "external", "fixateur", "was", "combined", "with", "both", ".", "Sudeck", "'s", "disease", "appeared", "in", "1.1", "%", "of", "all", "cases", ".", "In", "5", "cases", "we", "recorded", "complications", "with", "an", "obligation", "to", "treatment", "as", "well", ".", "Lesion", "of", "the", "superficial", "branch", "of", "the", "radial", "nerve", "were", "noted", "in", "2", "cases", "(", "2,1", "%", ")", ",", "as", "far", "as", "we", "extended", "the", "surgical", "approach", "for", "the", "pin", "application", ".", "Technical", "problems", "from", "the", "site", "of", "the", "external", "fixateur", "appeared", "in", "3", "cases", ",", "two", "of", "them", "could", "be", "attributed", "to", "an", "infirmity", "of", "the", "fixateurs", "ball", "joints", "which", "is", "now", "eliminated", "by", "the", "producer", ".", "4", "patients", "with", "a", "type", "-", "B", "fracture", "was", "provided", "by", "plating", ",", "additionally", "4", "patients", "with", "a", "type", "-", "C", "fracture", "because", "of", "non", "-", "compliance", ".", "The", "external", "fixateur", "is", "an", "essential", "part", "of", "a", "differentiated", "treatment", "with", "reference", "to", "the", "several", "types", "of", "distal", "radius", "fractures", "in", "older", "patients", "." ]	[ "umlsterm" ]
Interleukin-10 is a protein_molecule, interferon alpha- and interferon gamma- induced genes is a (AND DNA_family_or_group DNA_family_or_group), STAT1 is a protein_molecule	51430_task0	Sentence: Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: (AND DNA_family_or_group DNA_family_or_group), protein_molecule	[ "B-protein_molecule", "O", "O", "O", "O", "B-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "O", "O", "O", "O", "O", "B-protein_molecule", "O" ]	Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.	[ "Interleukin-10", "inhibits", "expression", "of", "both", "interferon", "alpha-", "and", "interferon", "gamma-", "induced", "genes", "by", "suppressing", "tyrosine", "phosphorylation", "of", "STAT1", "." ]	[ "protein_family_or_group", "(AND DNA_family_or_group DNA_family_or_group)", "(AND protein_complex protein_complex)", "(AND other_name other_name)", "other_name", "cell_type", "DNA_domain_or_region", "protein_molecule", "", "DNA_family_or_group", "amino_acid_monomer" ]
Interleukin-10 is a protein_molecule, interferon alpha- and interferon gamma- induced genes is a (AND DNA_family_or_group DNA_family_or_group), STAT1 is a protein_molecule	51430_task1	Sentence: Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Instructions: please typing these entity words according to sentence: Interleukin-10, interferon alpha- and interferon gamma- induced genes, STAT1 Options: (AND DNA_family_or_group DNA_family_or_group), protein_molecule	[ "B-protein_molecule", "O", "O", "O", "O", "B-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "O", "O", "O", "O", "O", "B-protein_molecule", "O" ]	Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.	[ "Interleukin-10", "inhibits", "expression", "of", "both", "interferon", "alpha-", "and", "interferon", "gamma-", "induced", "genes", "by", "suppressing", "tyrosine", "phosphorylation", "of", "STAT1", "." ]	[ "protein_family_or_group", "(AND DNA_family_or_group DNA_family_or_group)", "(AND protein_complex protein_complex)", "(AND other_name other_name)", "other_name", "cell_type", "DNA_domain_or_region", "protein_molecule", "", "DNA_family_or_group", "amino_acid_monomer" ]
Interleukin-10, interferon alpha- and interferon gamma- induced genes, STAT1	51430_task2	Sentence: Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Instructions: please extract entity words from the input sentence	[ "B-protein_molecule", "O", "O", "O", "O", "B-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "O", "O", "O", "O", "O", "B-protein_molecule", "O" ]	Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.	[ "Interleukin-10", "inhibits", "expression", "of", "both", "interferon", "alpha-", "and", "interferon", "gamma-", "induced", "genes", "by", "suppressing", "tyrosine", "phosphorylation", "of", "STAT1", "." ]	[ "protein_family_or_group", "(AND DNA_family_or_group DNA_family_or_group)", "(AND protein_complex protein_complex)", "(AND other_name other_name)", "other_name", "cell_type", "DNA_domain_or_region", "protein_molecule", "", "DNA_family_or_group", "amino_acid_monomer" ]
Analyse is an umlsterm, Arbeit is an umlsterm, Ausbildung is an umlsterm, Wahrnehmung is an umlsterm, Wissen is an umlsterm, Gegebenen is an umlsterm, selbst is an umlsterm, Wahnidee is an umlsterm, Wahnstimmung is an umlsterm, Wahnwahrnehmung is an umlsterm	DerNervenarzt.80690390.ger.abstr_task0	Sentence: Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang .	[ "Ausgehend", "vom", "Wahnproblem", "und", "begruendet", "auf", "einer", "Analyse", "rationaler", "und", "intuitiver", "Erkenntnis", ",", "unternimmt", "die", "vorliegende", "phaenomenologisch", "-", "konzeptuelle", "Arbeit", "den", "Versuch", "einer", "Wesensbestimmung", "des", "Wahns", ".", "Intuitive", "Erkenntnis", "als", "Resultat", "eines", "holistischen", "Erkenntnisvorganges", "beruht", "auf", "der", "Ausbildung", "polysensorisch", "-", "kinaesthetischer", "Grund-", "oder", "Wesensbilder", "(", "Wesensmatrizes", ")", ",", "die", "ihrerseits", "in", "uebergreifende", "Bedeutungssysteme", "einfliessen", "und", "ihrem", "praereflexiv", "-", "praeverbalen", "Wiedererkennen", "vermittels", "subliminaler", "Wahrnehmung", "entsprechender", "Wesensstrukturen", ".", "Ein", "positiver", "Abgleich", "evoziert", "eine", "Wesensempfindung", "als", "ein", "praeverbales", "Wissen", "von", "etwas", "als", "etwas", "Bestimmten", ".", "Gleichzeitig", "enthaelt", "die", "Wesensempfindung", "als", "unmittelbare", "Eigenbezueglichkeit", "das", "Empfinden", "der", "objektbedingten", "Bedeutung", "des", "Gegebenen", "fuer", "das", "Subjekt", "selbst", "sowie", "das", "Empfinden", "eines", "vom", "Objekt", "ausgehenden", "Kraftvektors", ".", "Vor", "diesem", "Hintergrund", "laesst", "sich", "Wahn", "als", "Ausdruck", "einer", "Stoerung", "im", "System", "intuitiv", "-", "holistischen", "Erkennens", "auffassen", ",", "bei", "der", "es", "auf", "verschiedenen", "Wegen", "zur", "Enthemmung", "und", "Aktualisierung", "von", "Wesensmatrizes", "bzw", ".", "einzelner", "umgreifender", "Bedeutungssysteme", "kommt", ".", "Die", "hierdurch", "evozierte", "Wesensempfindung", "nennen", "wir", "Wahn", ",", "deren", "begriffliche", "Expressionen", "Wahnidee", ".", "Am", "Wahn", "lassen", "sich", "alle", "Eigenschaften", "einer", "Wesensempfindung", "aufweisen", ",", "die", "jedoch", "ihrer", "besonderen", "Intensitaet", "entsprechend", "und", "der", "damit", "verbundenen", "Entmaechtigung", "der", "Ratio", "meist", "als", "unvergleichlich", "erscheinen", ".", "Die", "Herausarbeitung", "wesentlicher", "Eigenschaften", "des", "Wahns", "laesst", "ein", "Gefuege", "erkennen", ",", "das", "ein", "tieferes", "Verstaendnis", "dieses", "Phaenomens", "erlaubt", "und", "gleichermassen", "seine", "Identifizierung", "wie", "seine", "Abgrenzung", "erleichtert", ".", "Bisher", "wenig", "verbundene", "Begriffe", "wie", "Wahnstimmung", ",", "Beziehungsidee", ",", "Bedeutungserlebnis", ",", "Wahneinfall", "und", "Wahnwahrnehmung", "erscheinen", "in", "einem", "sinnvollen", "Zusammenhang", "." ]	[ "umlsterm" ]
Analyse is an umlsterm, Arbeit is an umlsterm, Ausbildung is an umlsterm, Wahrnehmung is an umlsterm, Wissen is an umlsterm, Gegebenen is an umlsterm, selbst is an umlsterm, Wahnidee is an umlsterm, Wahnstimmung is an umlsterm, Wahnwahrnehmung is an umlsterm	DerNervenarzt.80690390.ger.abstr_task1	Sentence: Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang . Instructions: please typing these entity words according to sentence: Analyse, Arbeit, Ausbildung, Wahrnehmung, Wissen, Gegebenen, selbst, Wahnidee, Wahnstimmung, Wahnwahrnehmung Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang .	[ "Ausgehend", "vom", "Wahnproblem", "und", "begruendet", "auf", "einer", "Analyse", "rationaler", "und", "intuitiver", "Erkenntnis", ",", "unternimmt", "die", "vorliegende", "phaenomenologisch", "-", "konzeptuelle", "Arbeit", "den", "Versuch", "einer", "Wesensbestimmung", "des", "Wahns", ".", "Intuitive", "Erkenntnis", "als", "Resultat", "eines", "holistischen", "Erkenntnisvorganges", "beruht", "auf", "der", "Ausbildung", "polysensorisch", "-", "kinaesthetischer", "Grund-", "oder", "Wesensbilder", "(", "Wesensmatrizes", ")", ",", "die", "ihrerseits", "in", "uebergreifende", "Bedeutungssysteme", "einfliessen", "und", "ihrem", "praereflexiv", "-", "praeverbalen", "Wiedererkennen", "vermittels", "subliminaler", "Wahrnehmung", "entsprechender", "Wesensstrukturen", ".", "Ein", "positiver", "Abgleich", "evoziert", "eine", "Wesensempfindung", "als", "ein", "praeverbales", "Wissen", "von", "etwas", "als", "etwas", "Bestimmten", ".", "Gleichzeitig", "enthaelt", "die", "Wesensempfindung", "als", "unmittelbare", "Eigenbezueglichkeit", "das", "Empfinden", "der", "objektbedingten", "Bedeutung", "des", "Gegebenen", "fuer", "das", "Subjekt", "selbst", "sowie", "das", "Empfinden", "eines", "vom", "Objekt", "ausgehenden", "Kraftvektors", ".", "Vor", "diesem", "Hintergrund", "laesst", "sich", "Wahn", "als", "Ausdruck", "einer", "Stoerung", "im", "System", "intuitiv", "-", "holistischen", "Erkennens", "auffassen", ",", "bei", "der", "es", "auf", "verschiedenen", "Wegen", "zur", "Enthemmung", "und", "Aktualisierung", "von", "Wesensmatrizes", "bzw", ".", "einzelner", "umgreifender", "Bedeutungssysteme", "kommt", ".", "Die", "hierdurch", "evozierte", "Wesensempfindung", "nennen", "wir", "Wahn", ",", "deren", "begriffliche", "Expressionen", "Wahnidee", ".", "Am", "Wahn", "lassen", "sich", "alle", "Eigenschaften", "einer", "Wesensempfindung", "aufweisen", ",", "die", "jedoch", "ihrer", "besonderen", "Intensitaet", "entsprechend", "und", "der", "damit", "verbundenen", "Entmaechtigung", "der", "Ratio", "meist", "als", "unvergleichlich", "erscheinen", ".", "Die", "Herausarbeitung", "wesentlicher", "Eigenschaften", "des", "Wahns", "laesst", "ein", "Gefuege", "erkennen", ",", "das", "ein", "tieferes", "Verstaendnis", "dieses", "Phaenomens", "erlaubt", "und", "gleichermassen", "seine", "Identifizierung", "wie", "seine", "Abgrenzung", "erleichtert", ".", "Bisher", "wenig", "verbundene", "Begriffe", "wie", "Wahnstimmung", ",", "Beziehungsidee", ",", "Bedeutungserlebnis", ",", "Wahneinfall", "und", "Wahnwahrnehmung", "erscheinen", "in", "einem", "sinnvollen", "Zusammenhang", "." ]	[ "umlsterm" ]
Analyse, Arbeit, Ausbildung, Wahrnehmung, Wissen, Gegebenen, selbst, Wahnidee, Wahnstimmung, Wahnwahrnehmung	DerNervenarzt.80690390.ger.abstr_task2	Sentence: Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang .	[ "Ausgehend", "vom", "Wahnproblem", "und", "begruendet", "auf", "einer", "Analyse", "rationaler", "und", "intuitiver", "Erkenntnis", ",", "unternimmt", "die", "vorliegende", "phaenomenologisch", "-", "konzeptuelle", "Arbeit", "den", "Versuch", "einer", "Wesensbestimmung", "des", "Wahns", ".", "Intuitive", "Erkenntnis", "als", "Resultat", "eines", "holistischen", "Erkenntnisvorganges", "beruht", "auf", "der", "Ausbildung", "polysensorisch", "-", "kinaesthetischer", "Grund-", "oder", "Wesensbilder", "(", "Wesensmatrizes", ")", ",", "die", "ihrerseits", "in", "uebergreifende", "Bedeutungssysteme", "einfliessen", "und", "ihrem", "praereflexiv", "-", "praeverbalen", "Wiedererkennen", "vermittels", "subliminaler", "Wahrnehmung", "entsprechender", "Wesensstrukturen", ".", "Ein", "positiver", "Abgleich", "evoziert", "eine", "Wesensempfindung", "als", "ein", "praeverbales", "Wissen", "von", "etwas", "als", "etwas", "Bestimmten", ".", "Gleichzeitig", "enthaelt", "die", "Wesensempfindung", "als", "unmittelbare", "Eigenbezueglichkeit", "das", "Empfinden", "der", "objektbedingten", "Bedeutung", "des", "Gegebenen", "fuer", "das", "Subjekt", "selbst", "sowie", "das", "Empfinden", "eines", "vom", "Objekt", "ausgehenden", "Kraftvektors", ".", "Vor", "diesem", "Hintergrund", "laesst", "sich", "Wahn", "als", "Ausdruck", "einer", "Stoerung", "im", "System", "intuitiv", "-", "holistischen", "Erkennens", "auffassen", ",", "bei", "der", "es", "auf", "verschiedenen", "Wegen", "zur", "Enthemmung", "und", "Aktualisierung", "von", "Wesensmatrizes", "bzw", ".", "einzelner", "umgreifender", "Bedeutungssysteme", "kommt", ".", "Die", "hierdurch", "evozierte", "Wesensempfindung", "nennen", "wir", "Wahn", ",", "deren", "begriffliche", "Expressionen", "Wahnidee", ".", "Am", "Wahn", "lassen", "sich", "alle", "Eigenschaften", "einer", "Wesensempfindung", "aufweisen", ",", "die", "jedoch", "ihrer", "besonderen", "Intensitaet", "entsprechend", "und", "der", "damit", "verbundenen", "Entmaechtigung", "der", "Ratio", "meist", "als", "unvergleichlich", "erscheinen", ".", "Die", "Herausarbeitung", "wesentlicher", "Eigenschaften", "des", "Wahns", "laesst", "ein", "Gefuege", "erkennen", ",", "das", "ein", "tieferes", "Verstaendnis", "dieses", "Phaenomens", "erlaubt", "und", "gleichermassen", "seine", "Identifizierung", "wie", "seine", "Abgrenzung", "erleichtert", ".", "Bisher", "wenig", "verbundene", "Begriffe", "wie", "Wahnstimmung", ",", "Beziehungsidee", ",", "Bedeutungserlebnis", ",", "Wahneinfall", "und", "Wahnwahrnehmung", "erscheinen", "in", "einem", "sinnvollen", "Zusammenhang", "." ]	[ "umlsterm" ]
Deep vein thrombosis is a Diseases & Disorders	12213_task0	Sentence: Deep vein thrombosis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Diseases & Disorders	[ "B-Diseases & Disorders", "I-Diseases & Disorders", "I-Diseases & Disorders", "O" ]	Deep vein thrombosis.	[ "Deep", "vein", "thrombosis", "." ]	[ "Chemicals & Drugs", "", "Diseases & Disorders" ]
Deep vein thrombosis is a Diseases & Disorders	12213_task1	Sentence: Deep vein thrombosis. Instructions: please typing these entity words according to sentence: Deep vein thrombosis Options: Diseases & Disorders	[ "B-Diseases & Disorders", "I-Diseases & Disorders", "I-Diseases & Disorders", "O" ]	Deep vein thrombosis.	[ "Deep", "vein", "thrombosis", "." ]	[ "Chemicals & Drugs", "", "Diseases & Disorders" ]
Deep vein thrombosis	12213_task2	Sentence: Deep vein thrombosis. Instructions: please extract entity words from the input sentence	[ "B-Diseases & Disorders", "I-Diseases & Disorders", "I-Diseases & Disorders", "O" ]	Deep vein thrombosis.	[ "Deep", "vein", "thrombosis", "." ]	[ "Chemicals & Drugs", "", "Diseases & Disorders" ]
Estrogen receptor beta is a GENE-Y, tamoxifen is a CHEMICAL, ERalpha is a GENE-Y	17404078_task0	Sentence: Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL	[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]	Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma.	[ "Estrogen", "receptor", "beta", "expression", "is", "associated", "with", "tamoxifen", "response", "in", "ERalpha", "-", "negative", "breast", "carcinoma", "." ]	[ "GENE-Y", "CHEMICAL" ]
Estrogen receptor beta is a GENE-Y, tamoxifen is a CHEMICAL, ERalpha is a GENE-Y	17404078_task1	Sentence: Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Instructions: please typing these entity words according to sentence: Estrogen receptor beta, tamoxifen, ERalpha Options: GENE-Y, CHEMICAL	[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]	Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma.	[ "Estrogen", "receptor", "beta", "expression", "is", "associated", "with", "tamoxifen", "response", "in", "ERalpha", "-", "negative", "breast", "carcinoma", "." ]	[ "GENE-Y", "CHEMICAL" ]
Estrogen receptor beta, tamoxifen, ERalpha	17404078_task2	Sentence: Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Instructions: please extract entity words from the input sentence	[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]	Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma.	[ "Estrogen", "receptor", "beta", "expression", "is", "associated", "with", "tamoxifen", "response", "in", "ERalpha", "-", "negative", "breast", "carcinoma", "." ]	[ "GENE-Y", "CHEMICAL" ]
p50 is a Protein, p50 is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein, RelB is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein, RelB is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein	9032344_task0	Sentence: Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals.	[ "Constitutive", "expression", "of", "p50", "homodimer", "in", "freshly", "isolated", "human", "monocytes", "decreases", "with", "in", "vitro", "and", "in", "vivo", "differentiation", ":", "a", "possible", "mechanism", "influencing", "human", "immunodeficiency", "virus", "replication", "in", "monocytes", "and", "mature", "macrophages", ".", "\n", "Human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "replicates", "more", "efficiently", "in", "vitro", "in", "differentiated", "macrophages", "than", "in", "freshly", "isolated", "monocytes", ".", "We", "investigated", "whether", "this", "may", "be", "partly", "explained", "by", "changes", "in", "expression", "of", "NF", "-", "kappaB", "with", "monocyte", "differentiation", ".", "We", "demonstrated", "that", "constitutive", "expression", "of", "NF", "-", "kappaB", "in", "primary", "human", "monocytes", "changed", "significantly", "with", "differentiation", "in", "vitro", "to", "monocyte", "-", "derived", "macrophages", "(", "MDMs", ")", "and", "differentiation", "in", "vivo", "to", "alveolar", "macrophages", "(", "AMs", ")", ".", "Freshly", "isolated", "monocytes", "constitutively", "expressed", "high", "levels", "of", "transcriptionally", "inactive", "p50", "homodimer", "which", "decreased", "with", "time", "in", "culture", "in", "favor", "of", "the", "transcriptionally", "active", "p50", "/", "p65", "and", "p50", "/", "RelB", "heterodimers", ".", "As", "in", "MDMs", ",", "AMs", "constitutively", "expressed", "p50", "/", "p65", "and", "p50", "/", "RelB", "although", "at", "lower", "levels", ".", "HIV", "infection", "of", "fresh", "monocytes", "failed", "to", "induce", "p50", "/", "p65", "as", "seen", "in", "MDMs", ".", "The", "replacement", "of", "p50", "homodimers", "with", "transcriptionally", "active", "heterodimers", "following", "time", "in", "culture", "may", "partially", "explain", "the", "progressive", "increase", "in", "susceptibility", "of", "monocytes", "to", "HIV", "infection", "during", "in", "vitro", "culture", ".", "The", "change", "in", "NF", "-", "kappaB", "components", "with", "monocyte", "differentiation", "in", "vivo", "may", "also", "explain", "the", "different", "transcriptional", "activities", "of", "these", "cell", "populations", "in", "HIV", "-", "infected", "individuals", "." ]	[ "Protein" ]
p50 is a Protein, p50 is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein, RelB is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein, RelB is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein	9032344_task1	Sentence: Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals. Instructions: please typing these entity words according to sentence: p50, p50, p50, p65, p50, RelB, p50, p65, p50, RelB, p50, p65, p50 Options: Protein	[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals.	[ "Constitutive", "expression", "of", "p50", "homodimer", "in", "freshly", "isolated", "human", "monocytes", "decreases", "with", "in", "vitro", "and", "in", "vivo", "differentiation", ":", "a", "possible", "mechanism", "influencing", "human", "immunodeficiency", "virus", "replication", "in", "monocytes", "and", "mature", "macrophages", ".", "\n", "Human", "immunodeficiency", "virus", "type", "1", "(", "HIV-1", ")", "replicates", "more", "efficiently", "in", "vitro", "in", "differentiated", "macrophages", "than", "in", "freshly", "isolated", "monocytes", ".", "We", "investigated", "whether", "this", "may", "be", "partly", "explained", "by", "changes", "in", "expression", "of", "NF", "-", "kappaB", "with", "monocyte", "differentiation", ".", "We", "demonstrated", "that", "constitutive", "expression", "of", "NF", "-", "kappaB", "in", "primary", "human", "monocytes", "changed", "significantly", "with", "differentiation", "in", "vitro", "to", "monocyte", "-", "derived", "macrophages", "(", "MDMs", ")", "and", "differentiation", "in", "vivo", "to", "alveolar", "macrophages", "(", "AMs", ")", ".", "Freshly", "isolated", "monocytes", "constitutively", "expressed", "high", "levels", "of", "transcriptionally", "inactive", "p50", "homodimer", "which", "decreased", "with", "time", "in", "culture", "in", "favor", "of", "the", "transcriptionally", "active", "p50", "/", "p65", "and", "p50", "/", "RelB", "heterodimers", ".", "As", "in", "MDMs", ",", "AMs", "constitutively", "expressed", "p50", "/", "p65", "and", "p50", "/", "RelB", "although", "at", "lower", "levels", ".", "HIV", "infection", "of", "fresh", "monocytes", "failed", "to", "induce", "p50", "/", "p65", "as", "seen", "in", "MDMs", ".", "The", "replacement", "of", "p50", "homodimers", "with", "transcriptionally", "active", "heterodimers", "following", "time", "in", "culture", "may", "partially", "explain", "the", "progressive", "increase", "in", "susceptibility", "of", "monocytes", "to", "HIV", "infection", "during", "in", "vitro", "culture", ".", "The", "change", "in", "NF", "-", "kappaB", "components", "with", "monocyte", "differentiation", "in", "vivo", "may", "also", "explain", "the", "different", "transcriptional", "activities", "of", "these", "cell", "populations", "in", "HIV", "-", "infected", "individuals", "." ]	[ "Protein" ]
p50, p50, p50, p65, p50, RelB, p50, p65, p50, RelB, p50, p65, p50	9032344_task2	Sentence: Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals.	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Geraet is an umlsterm, Kieferspalten is an umlsterm, Lippen- is an umlsterm, Kieferspaltverschluss is an umlsterm, Analyse is an umlsterm, Wachstums is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Kieferspaltverschluss is an umlsterm, Kieferorthopaede is an umlsterm, Patienten is an umlsterm, Wachstumsstoerung is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, offenen Biss is an umlsterm, Therapie is an umlsterm, Oberkieferlaenge is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Kreuzbisse is an umlsterm, Gebrauch is an umlsterm, Wachstumsstoerung is an umlsterm, Therapie is an umlsterm	MundKieferGesichtschirurgie.80020055.ger.abstr_task0	Sentence: Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden .	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Geraet is an umlsterm, Kieferspalten is an umlsterm, Lippen- is an umlsterm, Kieferspaltverschluss is an umlsterm, Analyse is an umlsterm, Wachstums is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Kieferspaltverschluss is an umlsterm, Kieferorthopaede is an umlsterm, Patienten is an umlsterm, Wachstumsstoerung is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, offenen Biss is an umlsterm, Therapie is an umlsterm, Oberkieferlaenge is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Kreuzbisse is an umlsterm, Gebrauch is an umlsterm, Wachstumsstoerung is an umlsterm, Therapie is an umlsterm	MundKieferGesichtschirurgie.80020055.ger.abstr_task1	Sentence: Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden . Instructions: please typing these entity words according to sentence: Geraet, Kieferspalten, Lippen-, Kieferspaltverschluss, Analyse, Wachstums, Patienten, Patienten, Patienten, Behandlung, Kieferspaltverschluss, Kieferorthopaede, Patienten, Wachstumsstoerung, Patienten, Patienten, offenen Biss, Therapie, Oberkieferlaenge, Patienten, Patienten, Kreuzbisse, Gebrauch, Wachstumsstoerung, Therapie Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden .	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Geraet, Kieferspalten, Lippen-, Kieferspaltverschluss, Analyse, Wachstums, Patienten, Patienten, Patienten, Behandlung, Kieferspaltverschluss, Kieferorthopaede, Patienten, Wachstumsstoerung, Patienten, Patienten, offenen Biss, Therapie, Oberkieferlaenge, Patienten, Patienten, Kreuzbisse, Gebrauch, Wachstumsstoerung, Therapie	MundKieferGesichtschirurgie.80020055.ger.abstr_task2	Sentence: Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden .	[ "Das", "von", "Latham", "entwickelte", "Geraet", "wird", "im", "Rahmen", "der", "aktiven", "praechirurgischen", "Vorbehandlung", "zur", "Verschmaelerung", "von", "Kieferspalten", "eingesetzt", ".", "Es", "soll", "den", "simultanen", "Lippen-", "und", "Kieferspaltverschluss", "im", "Alter", "von", "6", "Monaten", "(", "Gingivoperiostplastik", "nach", "Millard", ")", "ermoeglichen", ".", "Das", "Ziel", "dieser", "Untersuchung", "besteht", "in", "der", "Analyse", "des", "kraniofazialen", "Wachstums", "bei", "Patienten", "mit", "LKG", "-", "Spalten", "nach", "Einsatz", "des", "Latham", "-", "Geraets", ".", "Es", "wurden", "longitudinale", "Serien", "von", "lateralen", "Fernroentgenbildern", "sowie", "longitudinale", "Modellserien", "von", "insgesamt", "146", "Patienten", "untersucht", ".", "91", "dieser", "Patienten", "bildeten", "die", "Kontrollgruppe", "ohne", "Behandlung", "mit", "dem", "Latham", "-", "Geraet", "und", "ohne", "mukoperiostalen", "Kieferspaltverschluss", ".", "Ein", "und", "derselbe", "Chirurg", "und", "nur", "ein", "einziger", "Kieferorthopaede", "behandelten", "alle", "Patienten", "nach", "demselben", "Schema", ".", "Der", "Untersuchungszeitraum", "erstreckte", "sich", "ueber", "16", "Jahre", ".", "Eine", "dreidimensionale", "Wachstumsstoerung", "wurde", "nach", "Einsatz", "des", "Latham", "-", "Geraets", "sowie", "nachfolgender", "Gingivoperiostplastik", "beobachtet", ".", "42", "%", "der", "Patienten", "mit", "einseitigen", "und", "40", "%", "der", "Patienten", "mit", "doppelseitigen", "LKG", "-", "Spalten", "hatten", "einen", "frontal", "offenen", "Biss", "nach", "dieser", "Therapie", ".", "In", "der", "Kontrollgruppe", "waren", "es", "5", "bzw", ".", "10", "%", ".", "Weiterhin", "war", "die", "Oberkieferlaenge", "bei", "den", "Patienten", ",", "die", "mit", "einem", "Latham", "-", "Geraet", "und", "einer", "Gingivoperiostplastik", "behandelt", "wurden", ",", "zu", "gering", "und", "es", "traten", "bei", "diesen", "Patienten", "haeufiger", "frontale", "Kreuzbisse", "als", "in", "der", "Kontrollgruppe", "auf", ".", "Diese", "Ergebnisse", "belegen", ",", "dass", "der", "Gebrauch", "des", "Latham", "-", "Geraets", "und", "die", "anschliessende", "Gingivoperiostplastik", "zu", "einer", "fazialen", "Wachstumsstoerung", "fuehren", ".", "Deshalb", "sollte", "auf", "den", "Einsatz", "des", "Latham", "-", "Geraets", "in", "der", "Therapie", "ein-", "und", "doppelseitiger", "LKG", "-", "Spalten", "verzichtet", "werden", "." ]	[ "umlsterm" ]
macular is a Tissue	PMC-2908855-caption-01_task0	Sentence: The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Tissue	[ "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait.	[ "The", "pedigree", "of", "a", "Korean", "family", "with", "macular", "dystrophy", "demonstrating", "the", "characteristics", "of", "an", "autosomal", "dominant", "inheritance", "trait", ".", "\n" ]	[ "Tissue" ]
macular is a Tissue	PMC-2908855-caption-01_task1	Sentence: The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait. Instructions: please typing these entity words according to sentence: macular Options: Tissue	[ "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait.	[ "The", "pedigree", "of", "a", "Korean", "family", "with", "macular", "dystrophy", "demonstrating", "the", "characteristics", "of", "an", "autosomal", "dominant", "inheritance", "trait", ".", "\n" ]	[ "Tissue" ]
macular	PMC-2908855-caption-01_task2	Sentence: The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait.	[ "The", "pedigree", "of", "a", "Korean", "family", "with", "macular", "dystrophy", "demonstrating", "the", "characteristics", "of", "an", "autosomal", "dominant", "inheritance", "trait", ".", "\n" ]	[ "Tissue" ]
IL-12 is a protein_molecule, IL-2 is a protein_molecule, p38 mitogen - activated protein kinase is a protein_molecule, STAT serine phosphorylation is an other_name	46862_task0	Sentence: The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: other_name, protein_molecule	[ "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]	The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.	[ "The", "functional", "synergy", "between", "IL-12", "and", "IL-2", "involves", "p38", "mitogen", "-", "activated", "protein", "kinase", "and", "is", "associated", "with", "the", "augmentation", "of", "STAT", "serine", "phosphorylation", "." ]	[ "protein_molecule", "protein_family_or_group", "other_name", "(OR cell_type cell_type)", "cell_type", "", "amino_acid_monomer" ]
IL-12 is a protein_molecule, IL-2 is a protein_molecule, p38 mitogen - activated protein kinase is a protein_molecule, STAT serine phosphorylation is an other_name	46862_task1	Sentence: The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation. Instructions: please typing these entity words according to sentence: IL-12, IL-2, p38 mitogen - activated protein kinase, STAT serine phosphorylation Options: other_name, protein_molecule	[ "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]	The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.	[ "The", "functional", "synergy", "between", "IL-12", "and", "IL-2", "involves", "p38", "mitogen", "-", "activated", "protein", "kinase", "and", "is", "associated", "with", "the", "augmentation", "of", "STAT", "serine", "phosphorylation", "." ]	[ "protein_molecule", "protein_family_or_group", "other_name", "(OR cell_type cell_type)", "cell_type", "", "amino_acid_monomer" ]
IL-12, IL-2, p38 mitogen - activated protein kinase, STAT serine phosphorylation	46862_task2	Sentence: The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]	The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.	[ "The", "functional", "synergy", "between", "IL-12", "and", "IL-2", "involves", "p38", "mitogen", "-", "activated", "protein", "kinase", "and", "is", "associated", "with", "the", "augmentation", "of", "STAT", "serine", "phosphorylation", "." ]	[ "protein_molecule", "protein_family_or_group", "other_name", "(OR cell_type cell_type)", "cell_type", "", "amino_acid_monomer" ]
HIV - Infektion is an umlsterm	DerOpthalmologe.90960437.ger.abstr_task0	Sentence: Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind .	[ "Hintergrund", ":", "Die", "fruehesten", "Netzhautveraenderungen", "bei", "einer", "HIV", "-", "Infektion", "sind", "eine", "Mikroangiopathie", "mit", "Cotton", "-", "wool", "-", "Herden", "und", "Mikroaneurysmen", ".", "Mit", "der", "vorliegenden", "Studie", "soll", "geprueft", "werden", ",", "ob", "retinale", "Funktionsstoerungen", "vor", "morphologischen", "Veraenderungen", "mit", "nicht", "invasiven", "Mitteln", "nachweisbar", "und", "eventuell", "als", "prognostische", "Kriterien", "hilfreich", "sind", "." ]	[ "umlsterm" ]
HIV - Infektion is an umlsterm	DerOpthalmologe.90960437.ger.abstr_task1	Sentence: Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind . Instructions: please typing these entity words according to sentence: HIV - Infektion Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind .	[ "Hintergrund", ":", "Die", "fruehesten", "Netzhautveraenderungen", "bei", "einer", "HIV", "-", "Infektion", "sind", "eine", "Mikroangiopathie", "mit", "Cotton", "-", "wool", "-", "Herden", "und", "Mikroaneurysmen", ".", "Mit", "der", "vorliegenden", "Studie", "soll", "geprueft", "werden", ",", "ob", "retinale", "Funktionsstoerungen", "vor", "morphologischen", "Veraenderungen", "mit", "nicht", "invasiven", "Mitteln", "nachweisbar", "und", "eventuell", "als", "prognostische", "Kriterien", "hilfreich", "sind", "." ]	[ "umlsterm" ]
HIV - Infektion	DerOpthalmologe.90960437.ger.abstr_task2	Sentence: Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind .	[ "Hintergrund", ":", "Die", "fruehesten", "Netzhautveraenderungen", "bei", "einer", "HIV", "-", "Infektion", "sind", "eine", "Mikroangiopathie", "mit", "Cotton", "-", "wool", "-", "Herden", "und", "Mikroaneurysmen", ".", "Mit", "der", "vorliegenden", "Studie", "soll", "geprueft", "werden", ",", "ob", "retinale", "Funktionsstoerungen", "vor", "morphologischen", "Veraenderungen", "mit", "nicht", "invasiven", "Mitteln", "nachweisbar", "und", "eventuell", "als", "prognostische", "Kriterien", "hilfreich", "sind", "." ]	[ "umlsterm" ]
leukocyte is a Cell, nuclear body is a CellComponent, nuclear body is a CellComponent, NB is a CellComponent, cellular organelle is a CellComponent, NB is a CellComponent, antibodies is a Protein, serum is a PhysicalContinuant, cDNA is a DNA, NB is a CellComponent, protein is a Protein, Sp140 is a Protein, amino acid sequence is a AminoAcid, amino - terminal portion is a ProteinDomain, Sp140 is a Protein, Sp100 is a Protein, NB protein is a Protein, carboxyl portion is a ProteinDomain, Sp140 is a Protein, zinc - finger domain is a ZincCoordinatingDomain, bromodomain is a ProteinDomain, proteins is a Protein, gene is a Gene, Sp140 is a Protein, mRNA is a MessengerRNA, human is a Eukaryote, spleen is a Tissue, peripheral blood leukocytes is a Tissue, SP140 is a Protein, mRNA is a MessengerRNA, cell lines is a Cell, HL60 is a Cell, NB4 is a Cell, chemically is a Chemical, SP140 is a Protein, NB is a CellComponent, HL60 is a Cell, NB4 cells is a Cell, Sp140 is a Protein, NB is a CellComponent, gene is a Gene, cells is a Cell, Sp140 is a Protein	136_task0	Sentence: Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: AminoAcid, DNA, ZincCoordinatingDomain, Tissue, PhysicalContinuant, Chemical, CellComponent, MessengerRNA, Gene, Eukaryote, ProteinDomain, Protein, Cell	[ "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "B-CellComponent", "I-CellComponent", "O", "O", "B-CellComponent", "I-CellComponent", "O", "B-CellComponent", "O", "O", "O", "B-CellComponent", "I-CellComponent", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellComponent", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PhysicalContinuant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "O", "O", "O", "O", "O", "O", "B-CellComponent", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "B-AminoAcid", "I-AminoAcid", "I-AminoAcid", "O", "O", "B-ProteinDomain", "I-ProteinDomain", "I-ProteinDomain", "I-ProteinDomain", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "B-ProteinDomain", "I-ProteinDomain", "O", "B-Protein", "O", "O", "B-ZincCoordinatingDomain", "I-ZincCoordinatingDomain", "I-ZincCoordinatingDomain", "I-ZincCoordinatingDomain", "O", "O", "B-ProteinDomain", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Gene", "O", "O", "O", "O", "O", "B-Protein", "B-MessengerRNA", "O", "O", "O", "B-Eukaryote", "B-Tissue", "O", "B-Tissue", "I-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "B-MessengerRNA", "O", "O", "O", "B-Cell", "I-Cell", "B-Cell", "O", "B-Cell", "O", "O", "O", "O", "O", "B-Chemical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-CellComponent", "O", "O", "B-Cell", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "B-Protein", "O", "O", "B-CellComponent", "O", "O", "O", "O", "O", "B-Gene", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.	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leukocyte is a Cell, nuclear body is a CellComponent, nuclear body is a CellComponent, NB is a CellComponent, cellular organelle is a CellComponent, NB is a CellComponent, antibodies is a Protein, serum is a PhysicalContinuant, cDNA is a DNA, NB is a CellComponent, protein is a Protein, Sp140 is a Protein, amino acid sequence is a AminoAcid, amino - terminal portion is a ProteinDomain, Sp140 is a Protein, Sp100 is a Protein, NB protein is a Protein, carboxyl portion is a ProteinDomain, Sp140 is a Protein, zinc - finger domain is a ZincCoordinatingDomain, bromodomain is a ProteinDomain, proteins is a Protein, gene is a Gene, Sp140 is a Protein, mRNA is a MessengerRNA, human is a Eukaryote, spleen is a Tissue, peripheral blood leukocytes is a Tissue, SP140 is a Protein, mRNA is a MessengerRNA, cell lines is a Cell, HL60 is a Cell, NB4 is a Cell, chemically is a Chemical, SP140 is a Protein, NB is a CellComponent, HL60 is a Cell, NB4 cells is a Cell, Sp140 is a Protein, NB is a CellComponent, gene is a Gene, cells is a Cell, Sp140 is a Protein	136_task1	Sentence: Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. Instructions: please typing these entity words according to sentence: leukocyte, nuclear body, nuclear body, NB, cellular organelle, NB, antibodies, serum, cDNA, NB, protein, Sp140, amino acid sequence, amino - terminal portion, Sp140, Sp100, NB protein, carboxyl portion, Sp140, zinc - finger domain, bromodomain, proteins, gene, Sp140, mRNA, human, spleen, peripheral blood leukocytes, SP140, mRNA, cell lines, HL60, NB4, chemically, SP140, NB, HL60, NB4 cells, Sp140, NB, gene, cells, Sp140 Options: AminoAcid, DNA, ZincCoordinatingDomain, Tissue, PhysicalContinuant, Chemical, CellComponent, MessengerRNA, Gene, Eukaryote, ProteinDomain, Protein, Cell	[ "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "B-CellComponent", "I-CellComponent", "O", "O", "B-CellComponent", "I-CellComponent", "O", "B-CellComponent", "O", "O", "O", "B-CellComponent", "I-CellComponent", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellComponent", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-PhysicalContinuant", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "O", "O", "O", "O", "O", "O", "B-CellComponent", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "B-AminoAcid", "I-AminoAcid", "I-AminoAcid", "O", "O", "B-ProteinDomain", "I-ProteinDomain", "I-ProteinDomain", "I-ProteinDomain", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "B-ProteinDomain", "I-ProteinDomain", "O", "B-Protein", "O", "O", "B-ZincCoordinatingDomain", "I-ZincCoordinatingDomain", "I-ZincCoordinatingDomain", "I-ZincCoordinatingDomain", "O", "O", "B-ProteinDomain", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Gene", "O", "O", "O", "O", "O", "B-Protein", "B-MessengerRNA", "O", "O", "O", "B-Eukaryote", "B-Tissue", "O", "B-Tissue", "I-Tissue", "I-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "B-MessengerRNA", "O", "O", "O", "B-Cell", "I-Cell", "B-Cell", "O", "B-Cell", "O", "O", "O", "O", "O", "B-Chemical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-CellComponent", "O", "O", "B-Cell", "O", "B-Cell", "I-Cell", "O", "O", "O", "O", "B-Protein", "O", "O", "B-CellComponent", "O", "O", "O", "O", "O", "B-Gene", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.	[ "Identification", "and", "characterization", "of", "a", "leukocyte", "-", "specific", "component", "of", "the", "nuclear", "body", ".", "The", "nuclear", "body", "(", "NB", ")", "is", "a", "cellular", "organelle", "that", "is", "involved", "in", "the", "pathogenesis", "of", "acute", "promyelocytic", "leukemia", "and", "viral", "infection", ".", "The", "NB", "is", "also", "a", "target", "of", "antibodies", "in", "the", "serum", "of", "patients", "with", "the", "autoimmune", "disease", "primary", "biliary", "cirrhosis", ".", "In", "this", "study", ",", "serum", "from", "a", "patient", "with", "primary", "biliary", "cirrhosis", "was", "used", "to", "identify", "a", "cDNA", "encoding", "a", "novel", "component", "of", "the", "NB", ",", "a", "140-kDa", "protein", "designated", "Sp140", ".", "The", "predicted", "amino", "acid", "sequence", "of", "the", "amino", "-", "terminal", "portion", "of", "Sp140", "was", "similar", "to", "Sp100", ",", "a", "previously", "identified", "NB", "protein", ".", "The", "carboxyl", "portion", "of", "Sp140", "contained", "a", "zinc", "-", "finger", "domain", "and", "a", "bromodomain", ",", "motifs", "that", "are", "present", "in", "proteins", "regulating", "gene", "transcription", ".", "High", "levels", "of", "Sp140", "mRNA", "were", "detected", "in", "human", "spleen", "and", "peripheral", "blood", "leukocytes", ",", "but", "not", "other", "human", "tissues", ".", "The", "level", "of", "SP140", "mRNA", "in", "myeloid", "precursor", "cell", "lines", "HL60", "and", "NB4", "markedly", "increased", "in", "response", "to", "chemically", "induced", "cellular", "differentiation", ".", "Immunohistochemical", "techniques", "were", "used", "to", "demonstrate", "that", "SP140", "localized", "to", "the", "NB", "in", "differentiated", "HL60", "and", "NB4", "cells", ".", "The", "location", "of", "Sp140", "in", "the", "NB", ",", "and", "expression", "of", "this", "gene", "in", "cells", "involved", "in", "host", "defense", ",", "suggest", "that", "Sp140", "may", "be", "involved", "in", "the", "pathogenesis", "of", "acute", "promyelocytic", "leukemia", "and", "viral", "infection", ".", "\n" ]	[ "Tissue", "ProteinDomain", "AminoAcid", "CellComponent", "ZincCoordinatingDomain", "Protein", "Cell", "Chemical", "Eukaryote", "PhysicalContinuant", "DNA", "Gene", "MessengerRNA" ]
leukocyte, nuclear body, nuclear body, NB, cellular organelle, NB, antibodies, serum, cDNA, NB, protein, Sp140, amino acid sequence, amino - terminal portion, Sp140, Sp100, NB protein, carboxyl portion, Sp140, zinc - finger domain, bromodomain, proteins, gene, Sp140, mRNA, human, spleen, peripheral blood leukocytes, SP140, mRNA, cell lines, HL60, NB4, chemically, SP140, NB, HL60, NB4 cells, Sp140, NB, gene, cells, Sp140	136_task2	Sentence: Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. 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The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.	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case report is an umlsterm, old is an umlsterm, child is an umlsterm, methadone is an umlsterm, father is an umlsterm, drug is an umlsterm, time is an umlsterm, methadone is an umlsterm, heroin is an umlsterm, doctors is an umlsterm, signs is an umlsterm, opiate is an umlsterm, intoxication is an umlsterm, coma is an umlsterm, respiratory insufficiency is an umlsterm, diagnosis is an umlsterm, father is an umlsterm, drugs is an umlsterm, father is an umlsterm, drug is an umlsterm, child 's is an umlsterm, history is an umlsterm, methadone is an umlsterm, solution is an umlsterm, baby 's is an umlsterm, child is an umlsterm, methadone is an umlsterm, laboratory is an umlsterm, methadone is an umlsterm, urine is an umlsterm, antidote is an umlsterm, treatment is an umlsterm, naloxone is an umlsterm, body weight is an umlsterm, child is an umlsterm, antidote is an umlsterm	MonatsschriftKinderheilkunde.01480362.eng.abstr_task0	Sentence: This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later .	[ "This", "case", "report", "is", "on", "a", "15-month", "old", "child", "who", "became", "intoxicated", "by", "methadone", "prescribed", "to", "his", "father", ",", "a", "drug", "addict", ".", "He", "at", "that", "time", "was", "treated", "with", "methadone", "as", "a", "substitute", "for", "heroin", ".", "This", "fact", "was", "not", "known", "to", "the", "doctors", "on", "duty", ".", "In", "spite", "of", "the", "classical", "signs", "of", "opiate", "intoxication", "miosis", ",", "coma", ",", "and", "respiratory", "insufficiency", ",", "the", "presumed", "diagnosis", "was", "rejected", "because", "the", "father", "denied", "taking", "any", "drugs", "when", "being", "asked", ".", "It", "was", "not", "before", "the", "father", "admitted", "to", "be", "a", "drug", "addict", "that", "the", "child", "'s", "history", "became", "clear", ":", "The", "sweet", "and", "reddish", "methadone", "solution", "had", "been", "put", "into", "a", "baby", "'s", "bottle", "by", "the", "members", "in", "his", "doctor", "'s", "office", ".", "Back", "home", "the", "child", "took", "it", "as", "\"", "his", "\"", "bottle", "and", "swallowed", "some", "recalculated", "30", "mg", "of", "methadone", ".", "As", "soon", "as", "laboratory", "examination", "showed", "1.2", "mg", "/", "l", "methadone", "in", "the", "urine", "and", "0.1", "mg", "/", "l", "in", "the", "serum", ",", "repeated", "antidote", "treatment", "with", "0.01", "mg", "naloxone", "per", "kg", "body", "weight", "was", "started", ".", "After", "2", "days", "the", "child", "was", "able", "to", "breath", "sufficiently", "without", "taking", "the", "antidote", "and", "was", "discharged", "healthy", "1", "day", "later", "." ]	[ "umlsterm" ]
case report is an umlsterm, old is an umlsterm, child is an umlsterm, methadone is an umlsterm, father is an umlsterm, drug is an umlsterm, time is an umlsterm, methadone is an umlsterm, heroin is an umlsterm, doctors is an umlsterm, signs is an umlsterm, opiate is an umlsterm, intoxication is an umlsterm, coma is an umlsterm, respiratory insufficiency is an umlsterm, diagnosis is an umlsterm, father is an umlsterm, drugs is an umlsterm, father is an umlsterm, drug is an umlsterm, child 's is an umlsterm, history is an umlsterm, methadone is an umlsterm, solution is an umlsterm, baby 's is an umlsterm, child is an umlsterm, methadone is an umlsterm, laboratory is an umlsterm, methadone is an umlsterm, urine is an umlsterm, antidote is an umlsterm, treatment is an umlsterm, naloxone is an umlsterm, body weight is an umlsterm, child is an umlsterm, antidote is an umlsterm	MonatsschriftKinderheilkunde.01480362.eng.abstr_task1	Sentence: This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later . Instructions: please typing these entity words according to sentence: case report, old, child, methadone, father, drug, time, methadone, heroin, doctors, signs, opiate, intoxication, coma, respiratory insufficiency, diagnosis, father, drugs, father, drug, child 's, history, methadone, solution, baby 's, child, methadone, laboratory, methadone, urine, antidote, treatment, naloxone, body weight, child, antidote Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later .	[ "This", "case", "report", "is", "on", "a", "15-month", "old", "child", "who", "became", "intoxicated", "by", "methadone", "prescribed", "to", "his", "father", ",", "a", "drug", "addict", ".", "He", "at", "that", "time", "was", "treated", "with", "methadone", "as", "a", "substitute", "for", "heroin", ".", "This", "fact", "was", "not", "known", "to", "the", "doctors", "on", "duty", ".", "In", "spite", "of", "the", "classical", "signs", "of", "opiate", "intoxication", "miosis", ",", "coma", ",", "and", "respiratory", "insufficiency", ",", "the", "presumed", "diagnosis", "was", "rejected", "because", "the", "father", "denied", "taking", "any", "drugs", "when", "being", "asked", ".", "It", "was", "not", "before", "the", "father", "admitted", "to", "be", "a", "drug", "addict", "that", "the", "child", "'s", "history", "became", "clear", ":", "The", "sweet", "and", "reddish", "methadone", "solution", "had", "been", "put", "into", "a", "baby", "'s", "bottle", "by", "the", "members", "in", "his", "doctor", "'s", "office", ".", "Back", "home", "the", "child", "took", "it", "as", "\"", "his", "\"", "bottle", "and", "swallowed", "some", "recalculated", "30", "mg", "of", "methadone", ".", "As", "soon", "as", "laboratory", "examination", "showed", "1.2", "mg", "/", "l", "methadone", "in", "the", "urine", "and", "0.1", "mg", "/", "l", "in", "the", "serum", ",", "repeated", "antidote", "treatment", "with", "0.01", "mg", "naloxone", "per", "kg", "body", "weight", "was", "started", ".", "After", "2", "days", "the", "child", "was", "able", "to", "breath", "sufficiently", "without", "taking", "the", "antidote", "and", "was", "discharged", "healthy", "1", "day", "later", "." ]	[ "umlsterm" ]
case report, old, child, methadone, father, drug, time, methadone, heroin, doctors, signs, opiate, intoxication, coma, respiratory insufficiency, diagnosis, father, drugs, father, drug, child 's, history, methadone, solution, baby 's, child, methadone, laboratory, methadone, urine, antidote, treatment, naloxone, body weight, child, antidote	MonatsschriftKinderheilkunde.01480362.eng.abstr_task2	Sentence: This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later .	[ "This", "case", "report", "is", "on", "a", "15-month", "old", "child", "who", "became", "intoxicated", "by", "methadone", "prescribed", "to", "his", "father", ",", "a", "drug", "addict", ".", "He", "at", "that", "time", "was", "treated", "with", "methadone", "as", "a", "substitute", "for", "heroin", ".", "This", "fact", "was", "not", "known", "to", "the", "doctors", "on", "duty", ".", "In", "spite", "of", "the", "classical", "signs", "of", "opiate", "intoxication", "miosis", ",", "coma", ",", "and", "respiratory", "insufficiency", ",", "the", "presumed", "diagnosis", "was", "rejected", "because", "the", "father", "denied", "taking", "any", "drugs", "when", "being", "asked", ".", "It", "was", "not", "before", "the", "father", "admitted", "to", "be", "a", "drug", "addict", "that", "the", "child", "'s", "history", "became", "clear", ":", "The", "sweet", "and", "reddish", "methadone", "solution", "had", "been", "put", "into", "a", "baby", "'s", "bottle", "by", "the", "members", "in", "his", "doctor", "'s", "office", ".", "Back", "home", "the", "child", "took", "it", "as", "\"", "his", "\"", "bottle", "and", "swallowed", "some", "recalculated", "30", "mg", "of", "methadone", ".", "As", "soon", "as", "laboratory", "examination", "showed", "1.2", "mg", "/", "l", "methadone", "in", "the", "urine", "and", "0.1", "mg", "/", "l", "in", "the", "serum", ",", "repeated", "antidote", "treatment", "with", "0.01", "mg", "naloxone", "per", "kg", "body", "weight", "was", "started", ".", "After", "2", "days", "the", "child", "was", "able", "to", "breath", "sufficiently", "without", "taking", "the", "antidote", "and", "was", "discharged", "healthy", "1", "day", "later", "." ]	[ "umlsterm" ]
Unterkieferfrakturen is an umlsterm, Unterkieferfrakturen is an umlsterm, Frakturen is an umlsterm, Mandibula is an umlsterm, Therapiekonzepten is an umlsterm, Erhebung is an umlsterm, Charakter is an umlsterm, Unterkieferfraktur is an umlsterm, Klassifikation is an umlsterm, Fraktur is an umlsterm, Inzidenz is an umlsterm, Komplikationen is an umlsterm	MundKieferGesichtschirurgie.0004s103.ger.abstr_task0	Sentence: In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden .	[ "In", "der", "Versorgung", "von", "Unterkieferfrakturen", "konkurrieren", "bis", "heute", "die", "monokortikale", "und", "die", "funktionsstabile", "Kompressionsosteosynthese", "miteinander", ".", "Eine", "Uebersicht", "ueber", "die", "bestehende", "Litera", "-", "tur", "zeigt", ",", "dass", "komplizierte", "und", "schwer", "reponierbare", "Unterkieferfrakturen", "nach", "einer", "Kompressionsosteosynthese", "eine", "deutlich", "geringere", "Komplikationsrate", "aufweisen", ",", "waehrend", "einfache", "und", "nur", "gering", "dislozierte", "Frakturen", "im", "distalen", "Anteil", "der", "Mandibula", "auch", "mittels", "monokortikaler", "Miniplattenosteosynthese", "erfolgreich", "versorgt", "werden", "koennen", ".", "Wegweisend", "fuer", "eine", "geeignete", "Differenzialindikation", "zwischen", "beiden", "Therapiekonzepten", "scheint", "die", "Erhebung", "prae-", "und", "intraoperativer", "Parameter", ",", "die", "den", "Charakter", "einer", "Unterkieferfraktur", "beschreiben", "und", "additiv", "einen", "Rangwert", "zur", "Klassifikation", "eines", "Traumas", "bilden", ",", "zu", "sein", ".", "Doch", "bei", "nur", "7", "Einzelparametern", "-", "wie", "im", "mandibular", "fracture", "score", "-", "ergeben", "sich", "bereits", "so", "zahlreiche", "Kombinationen", "zur", "Beschreibung", "eines", "Unterkiefertraumas", ",", "dass", "saemtliche", "bisher", "angelegten", "Studien", "mit", "ihren", "geringen", "Fallzahlen", "allenfalls", "eine", "grobe", "Differenzialindikation", "ermoeglichen", "koennen", ".", "Solange", "keine", "prospektive", "Multizenterstudie", "vorliegt", ",", "die", "eine", "Entscheidungshilfe", "in", "der", "Wahl", "des", "Osteosyntheseverfahrens", "geben", "koennte", ",", "sollte", "im", "fliessenden", "Bereich", "zwischen", "einfacher", "\"", "und", "\"", "schwieriger", "\"", "Fraktur", "\"", "der", "funktionsstabilen", "Kompressionsosteosynthese", "mit", "ihrer", "deutlich", "geringeren", "Inzidenz", "postoperativer", "Komplikationen", "der", "Vorzug", "gegeben", "werden", "." ]	[ "umlsterm" ]
Unterkieferfrakturen is an umlsterm, Unterkieferfrakturen is an umlsterm, Frakturen is an umlsterm, Mandibula is an umlsterm, Therapiekonzepten is an umlsterm, Erhebung is an umlsterm, Charakter is an umlsterm, Unterkieferfraktur is an umlsterm, Klassifikation is an umlsterm, Fraktur is an umlsterm, Inzidenz is an umlsterm, Komplikationen is an umlsterm	MundKieferGesichtschirurgie.0004s103.ger.abstr_task1	Sentence: In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden . Instructions: please typing these entity words according to sentence: Unterkieferfrakturen, Unterkieferfrakturen, Frakturen, Mandibula, Therapiekonzepten, Erhebung, Charakter, Unterkieferfraktur, Klassifikation, Fraktur, Inzidenz, Komplikationen Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden .	[ "In", "der", "Versorgung", "von", "Unterkieferfrakturen", "konkurrieren", "bis", "heute", "die", "monokortikale", "und", "die", "funktionsstabile", "Kompressionsosteosynthese", "miteinander", ".", "Eine", "Uebersicht", "ueber", "die", "bestehende", "Litera", "-", "tur", "zeigt", ",", "dass", "komplizierte", "und", "schwer", "reponierbare", "Unterkieferfrakturen", "nach", "einer", "Kompressionsosteosynthese", "eine", "deutlich", "geringere", "Komplikationsrate", "aufweisen", ",", "waehrend", "einfache", "und", "nur", "gering", "dislozierte", "Frakturen", "im", "distalen", "Anteil", "der", "Mandibula", "auch", "mittels", "monokortikaler", "Miniplattenosteosynthese", "erfolgreich", "versorgt", "werden", "koennen", ".", "Wegweisend", "fuer", "eine", "geeignete", "Differenzialindikation", "zwischen", "beiden", "Therapiekonzepten", "scheint", "die", "Erhebung", "prae-", "und", "intraoperativer", "Parameter", ",", "die", "den", "Charakter", "einer", "Unterkieferfraktur", "beschreiben", "und", "additiv", "einen", "Rangwert", "zur", "Klassifikation", "eines", "Traumas", "bilden", ",", "zu", "sein", ".", "Doch", "bei", "nur", "7", "Einzelparametern", "-", "wie", "im", "mandibular", "fracture", "score", "-", "ergeben", "sich", "bereits", "so", "zahlreiche", "Kombinationen", "zur", "Beschreibung", "eines", "Unterkiefertraumas", ",", "dass", "saemtliche", "bisher", "angelegten", "Studien", "mit", "ihren", "geringen", "Fallzahlen", "allenfalls", "eine", "grobe", "Differenzialindikation", "ermoeglichen", "koennen", ".", "Solange", "keine", "prospektive", "Multizenterstudie", "vorliegt", ",", "die", "eine", "Entscheidungshilfe", "in", "der", "Wahl", "des", "Osteosyntheseverfahrens", "geben", "koennte", ",", "sollte", "im", "fliessenden", "Bereich", "zwischen", "einfacher", "\"", "und", "\"", "schwieriger", "\"", "Fraktur", "\"", "der", "funktionsstabilen", "Kompressionsosteosynthese", "mit", "ihrer", "deutlich", "geringeren", "Inzidenz", "postoperativer", "Komplikationen", "der", "Vorzug", "gegeben", "werden", "." ]	[ "umlsterm" ]
Unterkieferfrakturen, Unterkieferfrakturen, Frakturen, Mandibula, Therapiekonzepten, Erhebung, Charakter, Unterkieferfraktur, Klassifikation, Fraktur, Inzidenz, Komplikationen	MundKieferGesichtschirurgie.0004s103.ger.abstr_task2	Sentence: In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden .	[ "In", "der", "Versorgung", "von", "Unterkieferfrakturen", "konkurrieren", "bis", "heute", "die", "monokortikale", "und", "die", "funktionsstabile", "Kompressionsosteosynthese", "miteinander", ".", "Eine", "Uebersicht", "ueber", "die", "bestehende", "Litera", "-", "tur", "zeigt", ",", "dass", "komplizierte", "und", "schwer", "reponierbare", "Unterkieferfrakturen", "nach", "einer", "Kompressionsosteosynthese", "eine", "deutlich", "geringere", "Komplikationsrate", "aufweisen", ",", "waehrend", "einfache", "und", "nur", "gering", "dislozierte", "Frakturen", "im", "distalen", "Anteil", "der", "Mandibula", "auch", "mittels", "monokortikaler", "Miniplattenosteosynthese", "erfolgreich", "versorgt", "werden", "koennen", ".", "Wegweisend", "fuer", "eine", "geeignete", "Differenzialindikation", "zwischen", "beiden", "Therapiekonzepten", "scheint", "die", "Erhebung", "prae-", "und", "intraoperativer", "Parameter", ",", "die", "den", "Charakter", "einer", "Unterkieferfraktur", "beschreiben", "und", "additiv", "einen", "Rangwert", "zur", "Klassifikation", "eines", "Traumas", "bilden", ",", "zu", "sein", ".", "Doch", "bei", "nur", "7", "Einzelparametern", "-", "wie", "im", "mandibular", "fracture", "score", "-", "ergeben", "sich", "bereits", "so", "zahlreiche", "Kombinationen", "zur", "Beschreibung", "eines", "Unterkiefertraumas", ",", "dass", "saemtliche", "bisher", "angelegten", "Studien", "mit", "ihren", "geringen", "Fallzahlen", "allenfalls", "eine", "grobe", "Differenzialindikation", "ermoeglichen", "koennen", ".", "Solange", "keine", "prospektive", "Multizenterstudie", "vorliegt", ",", "die", "eine", "Entscheidungshilfe", "in", "der", "Wahl", "des", "Osteosyntheseverfahrens", "geben", "koennte", ",", "sollte", "im", "fliessenden", "Bereich", "zwischen", "einfacher", "\"", "und", "\"", "schwieriger", "\"", "Fraktur", "\"", "der", "funktionsstabilen", "Kompressionsosteosynthese", "mit", "ihrer", "deutlich", "geringeren", "Inzidenz", "postoperativer", "Komplikationen", "der", "Vorzug", "gegeben", "werden", "." ]	[ "umlsterm" ]
gastric metaplasia is a Outcome_Physical, patients with Helicobacter pylori positive duodenal bulb ulcer is a Participant_Condition, patients Helicobacter pylori - positive patients with duodenal bulb ulcer ( DBU ) is a Participant_Condition, One hundred and twenty four is a Participant_Sample-size, patients with DBU is a Participant_Condition, ( gastric metaplasia in the duodenum ) is a Outcome_Physical, Gastric metaplasia in the duodenum is a Outcome_Physical, sensitivity is a Outcome_Other, specificity is a Outcome_Other, predictive accuracy is a Outcome_Other, HP - positive patients is a Participant_Condition	35219_task0	Sentence: [ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Outcome_Physical, Participant_Condition, Participant_Sample-size	[ "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O" ]	[ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period .	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gastric metaplasia is a Outcome_Physical, patients with Helicobacter pylori positive duodenal bulb ulcer is a Participant_Condition, patients Helicobacter pylori - positive patients with duodenal bulb ulcer ( DBU ) is a Participant_Condition, One hundred and twenty four is a Participant_Sample-size, patients with DBU is a Participant_Condition, ( gastric metaplasia in the duodenum ) is a Outcome_Physical, Gastric metaplasia in the duodenum is a Outcome_Physical, sensitivity is a Outcome_Other, specificity is a Outcome_Other, predictive accuracy is a Outcome_Other, HP - positive patients is a Participant_Condition	35219_task1	Sentence: [ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period . Instructions: please typing these entity words according to sentence: gastric metaplasia, patients with Helicobacter pylori positive duodenal bulb ulcer, patients Helicobacter pylori - positive patients with duodenal bulb ulcer ( DBU ), One hundred and twenty four, patients with DBU, ( gastric metaplasia in the duodenum ), Gastric metaplasia in the duodenum, sensitivity, specificity, predictive accuracy, HP - positive patients Options: Outcome_Other, Outcome_Physical, Participant_Condition, Participant_Sample-size	[ "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O" ]	[ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period .	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gastric metaplasia, patients with Helicobacter pylori positive duodenal bulb ulcer, patients Helicobacter pylori - positive patients with duodenal bulb ulcer ( DBU ), One hundred and twenty four, patients with DBU, ( gastric metaplasia in the duodenum ), Gastric metaplasia in the duodenum, sensitivity, specificity, predictive accuracy, HP - positive patients	35219_task2	Sentence: [ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "B-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "I-Participant_Sample-size", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O" ]	[ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period .	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Flavopiridol is a CHEMICAL, flavopiridol is a CHEMICAL, flavonoid is a CHEMICAL, Flavopiridol is a CHEMICAL, cyclin - dependent kinase is a GENE-N, CDK2 is a GENE-Y, flavopiridol is a CHEMICAL, flavopiridol is a CHEMICAL, glucoronide is a CHEMICAL, uridine diphosphate is a CHEMICAL, Flavopiridol is a CHEMICAL, CDK is a GENE-N, flavopiridol is a CHEMICAL	14062_task0	Sentence: Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651]. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651].	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Flavopiridol is a CHEMICAL, flavopiridol is a CHEMICAL, flavonoid is a CHEMICAL, Flavopiridol is a CHEMICAL, cyclin - dependent kinase is a GENE-N, CDK2 is a GENE-Y, flavopiridol is a CHEMICAL, flavopiridol is a CHEMICAL, glucoronide is a CHEMICAL, uridine diphosphate is a CHEMICAL, Flavopiridol is a CHEMICAL, CDK is a GENE-N, flavopiridol is a CHEMICAL	14062_task1	Sentence: Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651]. Instructions: please typing these entity words according to sentence: Flavopiridol, flavopiridol, flavonoid, Flavopiridol, cyclin - dependent kinase, CDK2, flavopiridol, flavopiridol, glucoronide, uridine diphosphate, Flavopiridol, CDK, flavopiridol Options: GENE-Y, GENE-N, CHEMICAL	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651].	[ "Flavopiridol", "Hoechst", "AG", ".", "\n", "Hoechst", "is", "developing", "flavopiridol", ",", "a", "synthetic", "flavonoid", "based", "on", "an", "extract", "from", "an", "Indian", "plant", ",", "for", "the", "potential", "treatment", "of", "cancer", ".", "Flavopiridol", ",", "a", "cyclin", "-", "dependent", "kinase", "inhibitor", ",", "arrests", "cell", "division", "and", "causes", "apoptosis", "in", "non", "-", "small", "lung", "cancer", "cells", "[", "283660", "]", ".", "A", "phase", "II", "trial", ",", "in", "collaboration", "with", "the", "National", "Cancer", "Institute", ",", "has", "commenced", "at", "the", "University", "of", "Chicago", "Medical", "Center", ",", "which", "involves", "patients", "with", "high", "or", "intermediate", "-", "grade", "lymphoma", "or", "multiple", "myeloma", "[", "272937", "]", ",", "[", "277372", "]", ".", "In", "ex", "vivo", "experiments", "with", "tumor", "cells", "from", "refractory", "chronic", "lymphoblastic", "leukemia", ",", "dose", "-", "dependent", "CDK2", "inhibition", "associated", "with", "apoptotic", "changes", "was", "seen", "at", "concentrations", "greater", "than", "100", "nM", "of", "flavopiridol", ".", "In", "vitro", "pharmacokinetic", "studies", "have", "shown", "that", "flavopiridol", "undergoes", "hepatic", "biotransformation", "to", "its", "corresponding", "glucoronide", "by", "uridine", "diphosphate", "glucoronosyltransferases", "[", "283791", "]", ".", "Flavopiridol", "inhibits", "CDK", "with", "an", "IC50", "value", "of", "0.4", "mM", "[", "285707", "]", ".", "Preclinical", "toxicology", "studies", "in", "rats", "and", "dogs", "demonstrated", "dose", "-", "related", "leukopenia", "and", "drug", "-", "related", "lesions", "in", "the", "thymus", ",", "spleen", "and", "bone", "marrow", ".", "The", "gastrointestinal", "and", "bone", "marrow", "toxicity", "was", "dose", "-", "limiting", "[", "178579", "]", ".", "Hoechst", "Marion", "Roussel", "expects", "to", "launch", "flavopiridol", "in", "the", "year", "2001", ",", "with", "potential", "sales", "in", "excess", "of", "DM", "750", "million", "[", "288651", "]", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
Flavopiridol, flavopiridol, flavonoid, Flavopiridol, cyclin - dependent kinase, CDK2, flavopiridol, flavopiridol, glucoronide, uridine diphosphate, Flavopiridol, CDK, flavopiridol	14062_task2	Sentence: Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651]. Instructions: please extract entity words from the input sentence	[ "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651].	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proband 's is a cohort-patient, his is a gender, case is a cohort-patient, proband is a cohort-patient, his is a gender, proband 's is a cohort-patient, tumor is a disease, his is a gender, proband 's is a cohort-patient, tumor is a disease, his is a gender, dysfunction of the mismatch repair system is a Disorder, tumor is a disease, high frequency MSI is a Disorder, MSI - H is a Disorder, hMSH2 is a gene, hMLH1 is a gene, a c.1864C > A transversion in exon 12 is a mutation, hMSH2 is a gene, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution is a mutation, HNPCC is a disease, hMSH2 is a gene, hMSH2 is a gene, proband 's mother is a cohort-patient, Pro640Leu is a mutation, Pro622Leu is a mutation, hMSH2 is a gene, hMSH2 is a gene	29_task0	Sentence: IGNORE LINE IGNORE LINE IGNORE LINE Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: disease, cohort-patient, gender, Disorder, mutation, gene	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "I-cohort-patient", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gender", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gender", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "I-cohort-patient", "B-disease", "O", "O", "O", "O", "B-gender", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "I-cohort-patient", "O", "B-disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gender", "O", "O", "O", "O", "O", "O", "B-Disorder", "I-Disorder", "I-Disorder", "I-Disorder", "I-Disorder", "I-Disorder", "O", "O", "B-disease", "O", "O", "O", "B-Disorder", "I-Disorder", "I-Disorder", "O", "B-Disorder", "I-Disorder", "I-Disorder", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "I-cohort-patient", "I-cohort-patient", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	IGNORE LINE IGNORE LINE IGNORE LINE Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot	[ "", "", "IGNORE", "LINE", "", "", "\n", "", "", "IGNORE", "LINE", "", "", "\n", "", "", "IGNORE", "LINE", "", "", "\n", "Results", "and", "discussion", "\n\n", "Our", "work", "shows", "that", "the", "absence", "of", "proband", "'s", "non", "-", "tumor", "DNA", "for", "MSI", "testing", "can", "be", "overcome", "by", "studying", "the", "alleles", "carried", "by", "his", "progenitors", "avoiding", "the", "need", "for", "initial", "sequencing", "of", "the", "obligate", "carrier", ".", "\n\n", "Although", "BAT-26", "has", "been", "reported", "to", "be", "sufficient", "for", "MSI", "-", "H", "detection", "even", "without", "normal", "tissue", "matching", "[", "9", "]", ",", "careful", "interpretation", "is", "needed", "if", "MSI", "-", "H", "detection", "is", "based", "solely", "on", "this", "marker", ",", "since", "polymorphism", "at", "the", "BAT-26", "locus", "has", "been", "detected", "[", "10", "]", ".", "\n\n", "A", "more", "sensitive", "approach", "has", "been", "reported", "using", "a", "quasimonomorphic", "mononucleotide", "markers", "panel", "(", "that", "includes", "BAT-25", "and", "BAT-26", ")", "without", "the", "need", "to", "match", "normal", "DNA[11", "]", ".", "\n\n", "In", "the", "present", "case", ",", "we", "overcame", "the", "difficulty", "of", "having", "a", "proband", "post", "-", "mortem", "non", "-", "tumor", "tissue", "sample", "for", "MSI", "testing", "by", "studying", "the", "alleles", "carried", "by", "his", "progenitors", ".", "Microsatellites", "are", "inherited", "according", "to", "Mendelian", "rules", "like", "any", "other", "genetic", "markers", ".", "Each", "progenitor", "pass", "one", "of", "its", "two", "alleles", "to", "its", "offspring", "and", "by", "definition", ",", "the", "alleles", "present", "in", "the", "proband", "'s", "tumor", "tissue", "but", "absent", "in", "his", "progenitors", "are", "the", "result", "of", "somatic", "mutation", ".", "\n\n", "Three", "out", "of", "five", "microsatellite", "markers", "(", "BAT-25", ",", "BAT-26", "and", "D5S346", ")", "presented", "alleles", "in", "the", "proband", "'s", "primary", "tumor", "(", "T", "'", ")", "and", "its", "metastasis", "(", "T", "\"", ")", "different", "from", "those", "inherited", "from", "his", "parents", ".", "This", "observation", "suggested", "a", "dysfunction", "of", "the", "mismatch", "repair", "system", "and", "the", "tumor", "was", "classified", "as", "high", "frequency", "MSI", "(", "MSI", "-", "H", ")", "according", "to", "the", "NCI", "workshop", "[", "12", "]", ".", "Direct", "sequencing", "of", "the", "hMSH2", "and", "hMLH1", "genes", "was", "indicated", ",", "detecting", "a", "novel", "germline", "mutation", ",", "a", "c.1864C", ">", "A", "transversion", "in", "exon", "12", "of", "hMSH2", "gene", "at", "the", "heterozygous", "state", "(", "fig", ".", "3", ")", "leading", "to", "a", "proline", "622", "to", "threonine", "(", "p.", "Pro622Thr", ")", "amino", "acid", "substitution", ".", "This", "is", "the", "second", "report", "involving", "the", "622", "codon", "in", "HNPCC", "[", "13", "]", ".", "\n\n", "DNA", "sequence", "analysis", "of", "hMSH2", "exon", "12", ".", "Genomic", "DNA", "was", "isolated", "from", "leucocytes", "and", "PCR", "amplified", "with", "the", "help", "of", "hMSH2", "exon", "12", "flanking", "primers", ".", "In", "the", "image", "the", "result", "of", "the", "sequencing", "using", "the", "PCR", "forward", "primer", ".", "Panel", "A", ":", "proband", "'s", "mother", "(", "obligate", "carrier", ")", ",", "positive", "for", "the", "mutation", ".", "Panel", "B", ":", "negative", "control", "for", "the", "mutation", ".", "\n\n", "Evolutionary", "conservation", ",", "examined", "by", "alignment", "of", "sequences", "of", "homologous", "proteins", "for", "several", "species", "(", "fig", ".", "4", ")", ",", "suggests", "a", "functional", "relevance", "for", "the", "amino", "acid", "involved", ".", "This", "is", "also", "supported", "by", "the", "mutator", "phenotype", "described", "for", "Pro640Leu", "mutant", "yeast", "[", "14", "]", ",", "homologous", "to", "Pro622Leu", "hMSH2", "substitution", "in", "humans", "(", "fig", ".", "4", ")", ".", "\n\n", "Protein", "sequence", "alignment", "for", "hMSH2", "and", "homologues", ".", "Human", ",", "Mouse", ",", "Rat", ",", "Chicken", "and", "Saccharomyces", "cerevisiae", "(", "the", "site", "of", "mutation", "is", "highlighted", ")", "protein", "sequence", "alignment", ".", "Evolutionary", "conservation", "may", "indicate", "the", "functional", "relevance", "of", "the", "aminoacid", "involved", "for", "the", "structure", "or", "functioning", "of", "the", "protein", ".", "*", "UniProtKB", "/", "Swiss", "-", "Prot", "\n\n" ]	[ "mutation", "Disorder", "cohort-patient", "gender", "gene", "disease" ]
proband 's is a cohort-patient, his is a gender, case is a cohort-patient, proband is a cohort-patient, his is a gender, proband 's is a cohort-patient, tumor is a disease, his is a gender, proband 's is a cohort-patient, tumor is a disease, his is a gender, dysfunction of the mismatch repair system is a Disorder, tumor is a disease, high frequency MSI is a Disorder, MSI - H is a Disorder, hMSH2 is a gene, hMLH1 is a gene, a c.1864C > A transversion in exon 12 is a mutation, hMSH2 is a gene, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution is a mutation, HNPCC is a disease, hMSH2 is a gene, hMSH2 is a gene, proband 's mother is a cohort-patient, Pro640Leu is a mutation, Pro622Leu is a mutation, hMSH2 is a gene, hMSH2 is a gene	29_task1	Sentence: IGNORE LINE IGNORE LINE IGNORE LINE Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot Instructions: please typing these entity words according to sentence: proband 's, his, case, proband, his, proband 's, tumor, his, proband 's, tumor, his, dysfunction of the mismatch repair system, tumor, high frequency MSI, MSI - H, hMSH2, hMLH1, a c.1864C > A transversion in exon 12, hMSH2, proline 622 to threonine ( p. 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Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot	[ "", "", "IGNORE", "LINE", "", "", "\n", "", "", "IGNORE", "LINE", "", "", "\n", "", "", "IGNORE", "LINE", "", "", "\n", "Results", "and", "discussion", "\n\n", "Our", "work", "shows", "that", "the", "absence", "of", "proband", "'s", "non", "-", "tumor", "DNA", "for", "MSI", "testing", "can", "be", "overcome", "by", "studying", "the", "alleles", "carried", "by", "his", "progenitors", "avoiding", "the", "need", "for", "initial", "sequencing", "of", "the", "obligate", "carrier", ".", "\n\n", "Although", "BAT-26", "has", "been", "reported", "to", "be", "sufficient", "for", "MSI", "-", "H", "detection", "even", "without", "normal", "tissue", "matching", "[", "9", "]", ",", "careful", "interpretation", "is", "needed", "if", "MSI", "-", "H", "detection", "is", "based", "solely", "on", "this", "marker", ",", "since", "polymorphism", "at", "the", "BAT-26", "locus", "has", "been", "detected", "[", "10", "]", ".", "\n\n", "A", "more", "sensitive", "approach", "has", "been", "reported", "using", "a", "quasimonomorphic", "mononucleotide", "markers", "panel", "(", "that", "includes", "BAT-25", "and", "BAT-26", ")", "without", "the", "need", "to", "match", "normal", "DNA[11", "]", ".", "\n\n", "In", "the", "present", "case", ",", "we", "overcame", "the", "difficulty", "of", "having", "a", "proband", "post", "-", "mortem", "non", "-", "tumor", "tissue", "sample", "for", "MSI", "testing", "by", "studying", "the", "alleles", "carried", "by", "his", "progenitors", ".", "Microsatellites", "are", "inherited", "according", "to", "Mendelian", "rules", "like", "any", "other", "genetic", "markers", ".", "Each", "progenitor", "pass", "one", "of", "its", "two", "alleles", "to", "its", "offspring", "and", "by", "definition", ",", "the", "alleles", "present", "in", "the", "proband", "'s", "tumor", "tissue", "but", "absent", "in", "his", "progenitors", "are", "the", "result", "of", "somatic", "mutation", ".", "\n\n", "Three", "out", "of", "five", "microsatellite", "markers", "(", "BAT-25", ",", "BAT-26", "and", "D5S346", ")", "presented", "alleles", "in", "the", "proband", "'s", "primary", "tumor", "(", "T", "'", ")", "and", "its", "metastasis", "(", "T", "\"", ")", "different", "from", "those", "inherited", "from", "his", "parents", ".", "This", "observation", "suggested", "a", "dysfunction", "of", "the", "mismatch", "repair", "system", "and", "the", "tumor", "was", "classified", "as", "high", "frequency", "MSI", "(", "MSI", "-", "H", ")", "according", "to", "the", "NCI", "workshop", "[", "12", "]", ".", "Direct", "sequencing", "of", "the", "hMSH2", "and", "hMLH1", "genes", "was", "indicated", ",", "detecting", "a", "novel", "germline", "mutation", ",", "a", "c.1864C", ">", "A", "transversion", "in", "exon", "12", "of", "hMSH2", "gene", "at", "the", "heterozygous", "state", "(", "fig", ".", "3", ")", "leading", "to", "a", "proline", "622", "to", "threonine", "(", "p.", "Pro622Thr", ")", "amino", "acid", "substitution", ".", "This", "is", "the", "second", "report", "involving", "the", "622", "codon", "in", "HNPCC", "[", "13", "]", ".", "\n\n", "DNA", "sequence", "analysis", "of", "hMSH2", "exon", "12", ".", "Genomic", "DNA", "was", "isolated", "from", "leucocytes", "and", "PCR", "amplified", "with", "the", "help", "of", "hMSH2", "exon", "12", "flanking", "primers", ".", "In", "the", "image", "the", "result", "of", "the", "sequencing", "using", "the", "PCR", "forward", "primer", ".", "Panel", "A", ":", "proband", "'s", "mother", "(", "obligate", "carrier", ")", ",", "positive", "for", "the", "mutation", ".", "Panel", "B", ":", "negative", "control", "for", "the", "mutation", ".", "\n\n", "Evolutionary", "conservation", ",", "examined", "by", "alignment", "of", "sequences", "of", "homologous", "proteins", "for", "several", "species", "(", "fig", ".", "4", ")", ",", "suggests", "a", "functional", "relevance", "for", "the", "amino", "acid", "involved", ".", "This", "is", "also", "supported", "by", "the", "mutator", "phenotype", "described", "for", "Pro640Leu", "mutant", "yeast", "[", "14", "]", ",", "homologous", "to", "Pro622Leu", "hMSH2", "substitution", "in", "humans", "(", "fig", ".", "4", ")", ".", "\n\n", "Protein", "sequence", "alignment", "for", "hMSH2", "and", "homologues", ".", "Human", ",", "Mouse", ",", "Rat", ",", "Chicken", "and", "Saccharomyces", "cerevisiae", "(", "the", "site", "of", "mutation", "is", "highlighted", ")", "protein", "sequence", "alignment", ".", "Evolutionary", "conservation", "may", "indicate", "the", "functional", "relevance", "of", "the", "aminoacid", "involved", "for", "the", "structure", "or", "functioning", "of", "the", "protein", ".", "*", "UniProtKB", "/", "Swiss", "-", "Prot", "\n\n" ]	[ "mutation", "Disorder", "cohort-patient", "gender", "gene", "disease" ]
proband 's, his, case, proband, his, proband 's, tumor, his, proband 's, tumor, his, dysfunction of the mismatch repair system, tumor, high frequency MSI, MSI - H, hMSH2, hMLH1, a c.1864C > A transversion in exon 12, hMSH2, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution, HNPCC, hMSH2, hMSH2, proband 's mother, Pro640Leu, Pro622Leu, hMSH2, hMSH2	29_task2	Sentence: IGNORE LINE IGNORE LINE IGNORE LINE Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "I-cohort-patient", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gender", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gender", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "I-cohort-patient", "B-disease", "O", "O", "O", "O", "B-gender", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "I-cohort-patient", "O", "B-disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gender", "O", "O", "O", "O", "O", "O", "B-Disorder", "I-Disorder", "I-Disorder", "I-Disorder", "I-Disorder", "I-Disorder", "O", "O", "B-disease", "O", "O", "O", "B-Disorder", "I-Disorder", "I-Disorder", "O", "B-Disorder", "I-Disorder", "I-Disorder", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "I-mutation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-disease", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-cohort-patient", "I-cohort-patient", "I-cohort-patient", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "O", "O", "O", "O", "O", "O", "O", "O", "B-mutation", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-gene", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	IGNORE LINE IGNORE LINE IGNORE LINE Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot	[ "", "", "IGNORE", "LINE", "", "", "\n", "", "", "IGNORE", "LINE", "", "", "\n", "", "", "IGNORE", "LINE", "", "", "\n", "Results", "and", "discussion", "\n\n", "Our", "work", "shows", "that", "the", "absence", "of", "proband", "'s", "non", "-", "tumor", "DNA", "for", "MSI", "testing", "can", "be", "overcome", "by", "studying", "the", "alleles", "carried", "by", "his", "progenitors", "avoiding", "the", "need", "for", "initial", "sequencing", "of", "the", "obligate", "carrier", ".", "\n\n", "Although", "BAT-26", "has", "been", "reported", "to", "be", "sufficient", "for", "MSI", "-", "H", "detection", "even", "without", "normal", "tissue", "matching", "[", "9", "]", ",", "careful", "interpretation", "is", "needed", "if", "MSI", "-", "H", "detection", "is", "based", "solely", "on", "this", "marker", ",", "since", "polymorphism", "at", "the", "BAT-26", "locus", "has", "been", "detected", "[", "10", "]", ".", "\n\n", "A", "more", "sensitive", "approach", "has", "been", "reported", "using", "a", "quasimonomorphic", "mononucleotide", "markers", "panel", "(", "that", "includes", "BAT-25", "and", "BAT-26", ")", "without", "the", "need", "to", "match", "normal", "DNA[11", "]", ".", "\n\n", "In", "the", "present", "case", ",", "we", "overcame", "the", "difficulty", "of", "having", "a", "proband", "post", "-", "mortem", "non", "-", "tumor", "tissue", "sample", "for", "MSI", "testing", "by", "studying", "the", "alleles", "carried", "by", "his", "progenitors", ".", "Microsatellites", "are", "inherited", "according", "to", "Mendelian", "rules", "like", "any", "other", "genetic", "markers", ".", "Each", "progenitor", "pass", "one", "of", "its", "two", "alleles", "to", "its", "offspring", "and", "by", "definition", ",", "the", "alleles", "present", "in", "the", "proband", "'s", "tumor", "tissue", "but", "absent", "in", "his", "progenitors", "are", "the", "result", "of", "somatic", "mutation", ".", "\n\n", "Three", "out", "of", "five", "microsatellite", "markers", "(", "BAT-25", ",", "BAT-26", "and", "D5S346", ")", "presented", "alleles", "in", "the", "proband", "'s", "primary", "tumor", "(", "T", "'", ")", "and", "its", "metastasis", "(", "T", "\"", ")", "different", "from", "those", "inherited", "from", "his", "parents", ".", "This", "observation", "suggested", "a", "dysfunction", "of", "the", "mismatch", "repair", "system", "and", "the", "tumor", "was", "classified", "as", "high", "frequency", "MSI", "(", "MSI", "-", "H", ")", "according", "to", "the", "NCI", "workshop", "[", "12", "]", ".", "Direct", "sequencing", "of", "the", "hMSH2", "and", "hMLH1", "genes", "was", "indicated", ",", "detecting", "a", "novel", "germline", "mutation", ",", "a", "c.1864C", ">", "A", "transversion", "in", "exon", "12", "of", "hMSH2", "gene", "at", "the", "heterozygous", "state", "(", "fig", ".", "3", ")", "leading", "to", "a", "proline", "622", "to", "threonine", "(", "p.", "Pro622Thr", ")", "amino", "acid", "substitution", ".", "This", "is", "the", "second", "report", "involving", "the", "622", "codon", "in", "HNPCC", "[", "13", "]", ".", "\n\n", "DNA", "sequence", "analysis", "of", "hMSH2", "exon", "12", ".", "Genomic", "DNA", "was", "isolated", "from", "leucocytes", "and", "PCR", "amplified", "with", "the", "help", "of", "hMSH2", "exon", "12", "flanking", "primers", ".", "In", "the", "image", "the", "result", "of", "the", "sequencing", "using", "the", "PCR", "forward", "primer", ".", "Panel", "A", ":", "proband", "'s", "mother", "(", "obligate", "carrier", ")", ",", "positive", "for", "the", "mutation", ".", "Panel", "B", ":", "negative", "control", "for", "the", "mutation", ".", "\n\n", "Evolutionary", "conservation", ",", "examined", "by", "alignment", "of", "sequences", "of", "homologous", "proteins", "for", "several", "species", "(", "fig", ".", "4", ")", ",", "suggests", "a", "functional", "relevance", "for", "the", "amino", "acid", "involved", ".", "This", "is", "also", "supported", "by", "the", "mutator", "phenotype", "described", "for", "Pro640Leu", "mutant", "yeast", "[", "14", "]", ",", "homologous", "to", "Pro622Leu", "hMSH2", "substitution", "in", "humans", "(", "fig", ".", "4", ")", ".", "\n\n", "Protein", "sequence", "alignment", "for", "hMSH2", "and", "homologues", ".", "Human", ",", "Mouse", ",", "Rat", ",", "Chicken", "and", "Saccharomyces", "cerevisiae", "(", "the", "site", "of", "mutation", "is", "highlighted", ")", "protein", "sequence", "alignment", ".", "Evolutionary", "conservation", "may", "indicate", "the", "functional", "relevance", "of", "the", "aminoacid", "involved", "for", "the", "structure", "or", "functioning", "of", "the", "protein", ".", "*", "UniProtKB", "/", "Swiss", "-", "Prot", "\n\n" ]	[ "mutation", "Disorder", "cohort-patient", "gender", "gene", "disease" ]
dSir2 is a GENE-Y, dSir2 is a GENE-Y	23129806_task0	Sentence: Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y	[ "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]	Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles.	[ "Fat", "body", "dSir2", "regulates", "muscle", "mitochondrial", "physiology", "and", "energy", "homeostasis", "nonautonomously", "and", "mimics", "the", "autonomous", "functions", "of", "dSir2", "in", "muscles", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
dSir2 is a GENE-Y, dSir2 is a GENE-Y	23129806_task1	Sentence: Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles. Instructions: please typing these entity words according to sentence: dSir2, dSir2 Options: GENE-Y	[ "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]	Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles.	[ "Fat", "body", "dSir2", "regulates", "muscle", "mitochondrial", "physiology", "and", "energy", "homeostasis", "nonautonomously", "and", "mimics", "the", "autonomous", "functions", "of", "dSir2", "in", "muscles", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
dSir2, dSir2	23129806_task2	Sentence: Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]	Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles.	[ "Fat", "body", "dSir2", "regulates", "muscle", "mitochondrial", "physiology", "and", "energy", "homeostasis", "nonautonomously", "and", "mimics", "the", "autonomous", "functions", "of", "dSir2", "in", "muscles", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
silencer is a DNA_family_or_group, interleukin-2 gene is a DNA_domain_or_region, memory resting T helper lymphocytes is a cell_type	80784_task0	Sentence: Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, cell_type, DNA_domain_or_region	[ "O", "O", "O", "B-DNA_family_or_group", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O" ]	Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes.	[ "Occurrence", "of", "a", "silencer", "of", "the", "interleukin-2", "gene", "in", "naive", "but", "not", "in", "memory", "resting", "T", "helper", "lymphocytes", "." ]	[ "other_name", "cell_type", "DNA_domain_or_region", "cell_line", "protein_family_or_group", "protein_molecule", "DNA_family_or_group", "cell_component" ]
silencer is a DNA_family_or_group, interleukin-2 gene is a DNA_domain_or_region, memory resting T helper lymphocytes is a cell_type	80784_task1	Sentence: Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes. Instructions: please typing these entity words according to sentence: silencer, interleukin-2 gene, memory resting T helper lymphocytes Options: DNA_family_or_group, cell_type, DNA_domain_or_region	[ "O", "O", "O", "B-DNA_family_or_group", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O" ]	Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes.	[ "Occurrence", "of", "a", "silencer", "of", "the", "interleukin-2", "gene", "in", "naive", "but", "not", "in", "memory", "resting", "T", "helper", "lymphocytes", "." ]	[ "other_name", "cell_type", "DNA_domain_or_region", "cell_line", "protein_family_or_group", "protein_molecule", "DNA_family_or_group", "cell_component" ]
silencer, interleukin-2 gene, memory resting T helper lymphocytes	80784_task2	Sentence: Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-DNA_family_or_group", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O" ]	Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes.	[ "Occurrence", "of", "a", "silencer", "of", "the", "interleukin-2", "gene", "in", "naive", "but", "not", "in", "memory", "resting", "T", "helper", "lymphocytes", "." ]	[ "other_name", "cell_type", "DNA_domain_or_region", "cell_line", "protein_family_or_group", "protein_molecule", "DNA_family_or_group", "cell_component" ]
woman is an umlsterm, baby is an umlsterm, caesarean section is an umlsterm, placental abruption is an umlsterm, bradycardia is an umlsterm, dyspnea is an umlsterm, tachycardia is an umlsterm, hypotension is an umlsterm, transaminase is an umlsterm, pulmonary embolism is an umlsterm, CT scan is an umlsterm, hematoma is an umlsterm, liver is an umlsterm, vena cava is an umlsterm, laparotomy is an umlsterm, spontaneous rupture is an umlsterm, liver is an umlsterm, capsule is an umlsterm, hemorrhage is an umlsterm, liver is an umlsterm, hematoma is an umlsterm, postoperative is an umlsterm	DerChirurg.90700214.eng.abstr_task0	Sentence: A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful .	[ "A", "25-year", "-", "old", "woman", "delivered", "a", "healthy", "baby", "in", "the", "34th", "week", "of", "gestation", "by", "caesarean", "section", "due", "to", "placental", "abruption", "and", "fetal", "bradycardia", ".", "On", "the", "following", "day", "she", "developed", "dyspnea", ",", "tachycardia", ",", "hypotension", "and", "rising", "serum", "transaminase", "levels", ".", "After", "exclusion", "of", "a", "pulmonary", "embolism", ",", "the", "abdominal", "CT", "scan", "and", "cavography", "revealed", "a", "subcapsular", "hematoma", "of", "the", "entire", "dorsal", "liver", "surface", "and", "compression", "of", "the", "retrohepatic", "vena", "cava", ".", "During", "laparotomy", "a", "spontaneous", "rupture", "of", "the", "liver", "capsule", "with", "intraperitoneal", "hemorrhage", "was", "found", ".", "The", "dorsal", "liver", "was", "decapsulated", "and", "the", "subcapsular", "hematoma", "completely", "removed", ".", "The", "postoperative", "course", "was", "uneventful", "." ]	[ "umlsterm" ]
woman is an umlsterm, baby is an umlsterm, caesarean section is an umlsterm, placental abruption is an umlsterm, bradycardia is an umlsterm, dyspnea is an umlsterm, tachycardia is an umlsterm, hypotension is an umlsterm, transaminase is an umlsterm, pulmonary embolism is an umlsterm, CT scan is an umlsterm, hematoma is an umlsterm, liver is an umlsterm, vena cava is an umlsterm, laparotomy is an umlsterm, spontaneous rupture is an umlsterm, liver is an umlsterm, capsule is an umlsterm, hemorrhage is an umlsterm, liver is an umlsterm, hematoma is an umlsterm, postoperative is an umlsterm	DerChirurg.90700214.eng.abstr_task1	Sentence: A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful . Instructions: please typing these entity words according to sentence: woman, baby, caesarean section, placental abruption, bradycardia, dyspnea, tachycardia, hypotension, transaminase, pulmonary embolism, CT scan, hematoma, liver, vena cava, laparotomy, spontaneous rupture, liver, capsule, hemorrhage, liver, hematoma, postoperative Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful .	[ "A", "25-year", "-", "old", "woman", "delivered", "a", "healthy", "baby", "in", "the", "34th", "week", "of", "gestation", "by", "caesarean", "section", "due", "to", "placental", "abruption", "and", "fetal", "bradycardia", ".", "On", "the", "following", "day", "she", "developed", "dyspnea", ",", "tachycardia", ",", "hypotension", "and", "rising", "serum", "transaminase", "levels", ".", "After", "exclusion", "of", "a", "pulmonary", "embolism", ",", "the", "abdominal", "CT", "scan", "and", "cavography", "revealed", "a", "subcapsular", "hematoma", "of", "the", "entire", "dorsal", "liver", "surface", "and", "compression", "of", "the", "retrohepatic", "vena", "cava", ".", "During", "laparotomy", "a", "spontaneous", "rupture", "of", "the", "liver", "capsule", "with", "intraperitoneal", "hemorrhage", "was", "found", ".", "The", "dorsal", "liver", "was", "decapsulated", "and", "the", "subcapsular", "hematoma", "completely", "removed", ".", "The", "postoperative", "course", "was", "uneventful", "." ]	[ "umlsterm" ]
woman, baby, caesarean section, placental abruption, bradycardia, dyspnea, tachycardia, hypotension, transaminase, pulmonary embolism, CT scan, hematoma, liver, vena cava, laparotomy, spontaneous rupture, liver, capsule, hemorrhage, liver, hematoma, postoperative	DerChirurg.90700214.eng.abstr_task2	Sentence: A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful .	[ "A", "25-year", "-", "old", "woman", "delivered", "a", "healthy", "baby", "in", "the", "34th", "week", "of", "gestation", "by", "caesarean", "section", "due", "to", "placental", "abruption", "and", "fetal", "bradycardia", ".", "On", "the", "following", "day", "she", "developed", "dyspnea", ",", "tachycardia", ",", "hypotension", "and", "rising", "serum", "transaminase", "levels", ".", "After", "exclusion", "of", "a", "pulmonary", "embolism", ",", "the", "abdominal", "CT", "scan", "and", "cavography", "revealed", "a", "subcapsular", "hematoma", "of", "the", "entire", "dorsal", "liver", "surface", "and", "compression", "of", "the", "retrohepatic", "vena", "cava", ".", "During", "laparotomy", "a", "spontaneous", "rupture", "of", "the", "liver", "capsule", "with", "intraperitoneal", "hemorrhage", "was", "found", ".", "The", "dorsal", "liver", "was", "decapsulated", "and", "the", "subcapsular", "hematoma", "completely", "removed", ".", "The", "postoperative", "course", "was", "uneventful", "." ]	[ "umlsterm" ]
dye is an umlsterm, laser is an umlsterm, pulse is an umlsterm, treatment is an umlsterm, leg is an umlsterm, veins is an umlsterm, single is an umlsterm, test is an umlsterm, treatments is an umlsterm, test is an umlsterm, persons is an umlsterm, vessels is an umlsterm, treatments is an umlsterm, vessels is an umlsterm, Treatment is an umlsterm, vessels is an umlsterm, side effects is an umlsterm, hypopigmentation is an umlsterm, sclerotherapy is an umlsterm, laser is an umlsterm, device is an umlsterm, treatment is an umlsterm, leg is an umlsterm, vein is an umlsterm, ectasia is an umlsterm	DerHautarzt.80490560.eng.abstr_task0	Sentence: A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O" ]	A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia .	[ "A", "new", "flashlamp", "-", "pumped", "pulsed", "dye", "laser", "with", "1,5", "ms", "pulse", "length", "and", "tunable", "wavelengths", "between", "585", "and", "600", "nm", "(", "Candela", "ScleroPLUS", ")", "is", "now", "available", "for", "the", "treatment", "of", "ectatic", "leg", "veins", ".", "We", "evaluated", "232", "single", "test", "treatments", "using", "595", "and", "600", "nm", "wavelength", "in", "75", "test", "persons", ".", "For", "smaller", "vessels", "up", "to", "a", "diameter", "of", "0,5", "mm", ",", "treatments", "at", "16", "and", "18", "J", "/", "cm2", "showed", "good", "results", "in", "60", "and", "82", "%", "respectively", ";", "for", "vessels", "up", "to", "1", "mm", "in", "27", "and", "33", "%", ".", "Treatment", "at", "595", "nm", "was", "a", "little", "more", "effective", "than", "at", "600", "nm", ".", "Larger", "vessels", "could", "not", "be", "treated", "effectively", ".", "The", "main", "side", "effects", "consisted", "in", "hyper-", "(", "34", "%", ")", "or", "hypopigmentation", "(", "30", "%", ")", ".", "Thus", ",", "in", "addition", "to", "the", "usual", "sclerotherapy", ",", "this", "laser", "is", "a", "useful", "device", "for", "the", "treatment", "of", "leg", "vein", "ectasia", "." ]	[ "umlsterm" ]
dye is an umlsterm, laser is an umlsterm, pulse is an umlsterm, treatment is an umlsterm, leg is an umlsterm, veins is an umlsterm, single is an umlsterm, test is an umlsterm, treatments is an umlsterm, test is an umlsterm, persons is an umlsterm, vessels is an umlsterm, treatments is an umlsterm, vessels is an umlsterm, Treatment is an umlsterm, vessels is an umlsterm, side effects is an umlsterm, hypopigmentation is an umlsterm, sclerotherapy is an umlsterm, laser is an umlsterm, device is an umlsterm, treatment is an umlsterm, leg is an umlsterm, vein is an umlsterm, ectasia is an umlsterm	DerHautarzt.80490560.eng.abstr_task1	Sentence: A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia . Instructions: please typing these entity words according to sentence: dye, laser, pulse, treatment, leg, veins, single, test, treatments, test, persons, vessels, treatments, vessels, Treatment, vessels, side effects, hypopigmentation, sclerotherapy, laser, device, treatment, leg, vein, ectasia Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O" ]	A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia .	[ "A", "new", "flashlamp", "-", "pumped", "pulsed", "dye", "laser", "with", "1,5", "ms", "pulse", "length", "and", "tunable", "wavelengths", "between", "585", "and", "600", "nm", "(", "Candela", "ScleroPLUS", ")", "is", "now", "available", "for", "the", "treatment", "of", "ectatic", "leg", "veins", ".", "We", "evaluated", "232", "single", "test", "treatments", "using", "595", "and", "600", "nm", "wavelength", "in", "75", "test", "persons", ".", "For", "smaller", "vessels", "up", "to", "a", "diameter", "of", "0,5", "mm", ",", "treatments", "at", "16", "and", "18", "J", "/", "cm2", "showed", "good", "results", "in", "60", "and", "82", "%", "respectively", ";", "for", "vessels", "up", "to", "1", "mm", "in", "27", "and", "33", "%", ".", "Treatment", "at", "595", "nm", "was", "a", "little", "more", "effective", "than", "at", "600", "nm", ".", "Larger", "vessels", "could", "not", "be", "treated", "effectively", ".", "The", "main", "side", "effects", "consisted", "in", "hyper-", "(", "34", "%", ")", "or", "hypopigmentation", "(", "30", "%", ")", ".", "Thus", ",", "in", "addition", "to", "the", "usual", "sclerotherapy", ",", "this", "laser", "is", "a", "useful", "device", "for", "the", "treatment", "of", "leg", "vein", "ectasia", "." ]	[ "umlsterm" ]
dye, laser, pulse, treatment, leg, veins, single, test, treatments, test, persons, vessels, treatments, vessels, Treatment, vessels, side effects, hypopigmentation, sclerotherapy, laser, device, treatment, leg, vein, ectasia	DerHautarzt.80490560.eng.abstr_task2	Sentence: A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O" ]	A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia .	[ "A", "new", "flashlamp", "-", "pumped", "pulsed", "dye", "laser", "with", "1,5", "ms", "pulse", "length", "and", "tunable", "wavelengths", "between", "585", "and", "600", "nm", "(", "Candela", "ScleroPLUS", ")", "is", "now", "available", "for", "the", "treatment", "of", "ectatic", "leg", "veins", ".", "We", "evaluated", "232", "single", "test", "treatments", "using", "595", "and", "600", "nm", "wavelength", "in", "75", "test", "persons", ".", "For", "smaller", "vessels", "up", "to", "a", "diameter", "of", "0,5", "mm", ",", "treatments", "at", "16", "and", "18", "J", "/", "cm2", "showed", "good", "results", "in", "60", "and", "82", "%", "respectively", ";", "for", "vessels", "up", "to", "1", "mm", "in", "27", "and", "33", "%", ".", "Treatment", "at", "595", "nm", "was", "a", "little", "more", "effective", "than", "at", "600", "nm", ".", "Larger", "vessels", "could", "not", "be", "treated", "effectively", ".", "The", "main", "side", "effects", "consisted", "in", "hyper-", "(", "34", "%", ")", "or", "hypopigmentation", "(", "30", "%", ")", ".", "Thus", ",", "in", "addition", "to", "the", "usual", "sclerotherapy", ",", "this", "laser", "is", "a", "useful", "device", "for", "the", "treatment", "of", "leg", "vein", "ectasia", "." ]	[ "umlsterm" ]
insulin is a GENE-Y	23489521_task0	Sentence: The use of insulin analogues in pregnancy. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y	[ "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O" ]	The use of insulin analogues in pregnancy.	[ "The", "use", "of", "insulin", "analogues", "in", "pregnancy", "." ]	[ "GENE-Y", "CHEMICAL" ]
insulin is a GENE-Y	23489521_task1	Sentence: The use of insulin analogues in pregnancy. Instructions: please typing these entity words according to sentence: insulin Options: GENE-Y	[ "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O" ]	The use of insulin analogues in pregnancy.	[ "The", "use", "of", "insulin", "analogues", "in", "pregnancy", "." ]	[ "GENE-Y", "CHEMICAL" ]
insulin	23489521_task2	Sentence: The use of insulin analogues in pregnancy. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O" ]	The use of insulin analogues in pregnancy.	[ "The", "use", "of", "insulin", "analogues", "in", "pregnancy", "." ]	[ "GENE-Y", "CHEMICAL" ]
defects is an umlsterm, pelvic region is an umlsterm, sequelae is an umlsterm, debridement is an umlsterm, tissue is an umlsterm, patient is an umlsterm, plastic surgery is an umlsterm, procedures is an umlsterm, therapeutic is an umlsterm	DerChirurg.70680469.eng.abstr_task0	Sentence: Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept .	[ "Complex", "defects", "of", "the", "trunk", "and", "pelvic", "region", "are", "rare", ",", "but", "are", "mostly", "the", "sequelae", "of", "serious", "conditions", ".", "Stable", "soft", "tisue", "coverage", "after", "radical", "debridement", "of", "all", "avital", "tissue", "may", "be", "of", "vital", "importance", "for", "the", "patient", ".", "The", "article", "will", "demonstrate", "the", "options", "of", "plastic", "surgery", "procedures", "that", "should", "be", "known", "by", "the", "general", "surgeon", "to", "be", "eventually", "integrated", "into", "a", "interdisciplinary", "therapeutic", "concept", "." ]	[ "umlsterm" ]
defects is an umlsterm, pelvic region is an umlsterm, sequelae is an umlsterm, debridement is an umlsterm, tissue is an umlsterm, patient is an umlsterm, plastic surgery is an umlsterm, procedures is an umlsterm, therapeutic is an umlsterm	DerChirurg.70680469.eng.abstr_task1	Sentence: Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept . Instructions: please typing these entity words according to sentence: defects, pelvic region, sequelae, debridement, tissue, patient, plastic surgery, procedures, therapeutic Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept .	[ "Complex", "defects", "of", "the", "trunk", "and", "pelvic", "region", "are", "rare", ",", "but", "are", "mostly", "the", "sequelae", "of", "serious", "conditions", ".", "Stable", "soft", "tisue", "coverage", "after", "radical", "debridement", "of", "all", "avital", "tissue", "may", "be", "of", "vital", "importance", "for", "the", "patient", ".", "The", "article", "will", "demonstrate", "the", "options", "of", "plastic", "surgery", "procedures", "that", "should", "be", "known", "by", "the", "general", "surgeon", "to", "be", "eventually", "integrated", "into", "a", "interdisciplinary", "therapeutic", "concept", "." ]	[ "umlsterm" ]
defects, pelvic region, sequelae, debridement, tissue, patient, plastic surgery, procedures, therapeutic	DerChirurg.70680469.eng.abstr_task2	Sentence: Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept .	[ "Complex", "defects", "of", "the", "trunk", "and", "pelvic", "region", "are", "rare", ",", "but", "are", "mostly", "the", "sequelae", "of", "serious", "conditions", ".", "Stable", "soft", "tisue", "coverage", "after", "radical", "debridement", "of", "all", "avital", "tissue", "may", "be", "of", "vital", "importance", "for", "the", "patient", ".", "The", "article", "will", "demonstrate", "the", "options", "of", "plastic", "surgery", "procedures", "that", "should", "be", "known", "by", "the", "general", "surgeon", "to", "be", "eventually", "integrated", "into", "a", "interdisciplinary", "therapeutic", "concept", "." ]	[ "umlsterm" ]
Angioplasty is an umlsterm, syndromes is an umlsterm, vessel is an umlsterm, stent - like is an umlsterm, angioplasty is an umlsterm, PTCA is an umlsterm, vessel is an umlsterm, syndromes is an umlsterm, prospective study is an umlsterm, patients is an umlsterm, myocardial infarction is an umlsterm, unstable angina is an umlsterm, PTCA is an umlsterm, patients is an umlsterm, angiography is an umlsterm, All is an umlsterm, angiograms is an umlsterm, measurements is an umlsterm, vessel is an umlsterm, patients is an umlsterm, patients is an umlsterm, analysis is an umlsterm, risk factors is an umlsterm, diabetes mellitus is an umlsterm, relative risk is an umlsterm, hypertension is an umlsterm, stenosis is an umlsterm, stents is an umlsterm, multivariate analysis is an umlsterm, hypertension is an umlsterm, risk factors is an umlsterm, Diabetes is an umlsterm, risk factor is an umlsterm, patients is an umlsterm, PTCA is an umlsterm, occurrence is an umlsterm, vessel is an umlsterm, patients is an umlsterm, PTCA is an umlsterm, stents is an umlsterm, stenosis is an umlsterm, procedure is an umlsterm, diabetes is an umlsterm, hypertension is an umlsterm	ZfuerKardiologie.00890485.eng.abstr_task0	Sentence: Angioplasty in acute coronary syndromes is complicated by a high rate of early vessel reocclusion and restenosis . Therefore , it is recommended to achieve a " stent-like " result by percutaneous transluminal coronary angioplasty ( PTCA ) or otherwise use coronary stenting ( provisional stenting ) . This study sought to determine angiographic and patient-related factors that are associated with early target vessel reocclusion or luminal renarrowing after coronary intervention in acute coronary syndromes ( ACS ) . In an observational prospective study we investigated 161 patients with ACS ( acute myocardial infarction and unstable angina ) submitted to PTCA . In 140 patients a follow-up angiography after 10 days was obtained . All angiograms were quantitatively evaluated by computerized measurements . Target vessel reocclusion and early luminal renarrowing was observed in 10 patients ( 7.1% ) and 19 patients ( 13.6% ) , respectively . Using univariate analysis , significant risk factors ( P 0.05 ) for early reocclusion and renarrowing were diabetes mellitus ( relative risk [ RR ] 6.1 and 5.0 ) , arterial hypertension ( RR 7.7 and 3.3 ) , postprocedural lesion length > =2 . 5mm ( RR 6.8 and 7.1 ) , postprocedural minimal lumen diameter =2 . 5 mm ( RR9.0 and 5.8 ) , residual stenosis > =25% ( RR 4.8 and 3.5 ) and absence of stents ( RR 4.1 and 3.2 ) . Moreover , in multivariate analysis hypertension and postprocedural lesion length could be identified as independent risk factors for reocclusion and renarrowing . Diabetes mellitus was found to be an independent risk factor for renarrowing . Conclusions : In a consecutive series of patients with ACS undergoing PTCA with provisional stenting the occurrence of early target vessel reocclusion and luminal renarrowing is lower than previously reported for this subset of patients treated by PTCA alone . Adverse outcome is related to absence of stents , angiographic factors ( residual stenosis , lesion length , minimal lumen diameter after procedure ) and patient-related factors such as diabetes and hypertension . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Angioplasty in acute coronary syndromes is complicated by a high rate of early vessel reocclusion and restenosis . Therefore , it is recommended to achieve a " stent-like " result by percutaneous transluminal coronary angioplasty ( PTCA ) or otherwise use coronary stenting ( provisional stenting ) . This study sought to determine angiographic and patient-related factors that are associated with early target vessel reocclusion or luminal renarrowing after coronary intervention in acute coronary syndromes ( ACS ) . In an observational prospective study we investigated 161 patients with ACS ( acute myocardial infarction and unstable angina ) submitted to PTCA . In 140 patients a follow-up angiography after 10 days was obtained . All angiograms were quantitatively evaluated by computerized measurements . Target vessel reocclusion and early luminal renarrowing was observed in 10 patients ( 7.1% ) and 19 patients ( 13.6% ) , respectively . Using univariate analysis , significant risk factors ( P 0.05 ) for early reocclusion and renarrowing were diabetes mellitus ( relative risk [ RR ] 6.1 and 5.0 ) , arterial hypertension ( RR 7.7 and 3.3 ) , postprocedural lesion length > =2 . 5mm ( RR 6.8 and 7.1 ) , postprocedural minimal lumen diameter =2 . 5 mm ( RR9.0 and 5.8 ) , residual stenosis > =25% ( RR 4.8 and 3.5 ) and absence of stents ( RR 4.1 and 3.2 ) . Moreover , in multivariate analysis hypertension and postprocedural lesion length could be identified as independent risk factors for reocclusion and renarrowing . Diabetes mellitus was found to be an independent risk factor for renarrowing . Conclusions : In a consecutive series of patients with ACS undergoing PTCA with provisional stenting the occurrence of early target vessel reocclusion and luminal renarrowing is lower than previously reported for this subset of patients treated by PTCA alone . Adverse outcome is related to absence of stents , angiographic factors ( residual stenosis , lesion length , minimal lumen diameter after procedure ) and patient-related factors such as diabetes and hypertension .	[ "Angioplasty", "in", "acute", "coronary", "syndromes", "is", "complicated", "by", "a", "high", "rate", "of", "early", "vessel", "reocclusion", "and", "restenosis", ".", "Therefore", ",", "it", "is", "recommended", "to", "achieve", "a", "\"", "stent", "-", "like", "\"", "result", "by", "percutaneous", "transluminal", "coronary", "angioplasty", "(", "PTCA", ")", "or", "otherwise", "use", "coronary", "stenting", "(", "provisional", "stenting", ")", ".", "This", "study", "sought", "to", "determine", "angiographic", "and", "patient", "-", "related", "factors", "that", "are", "associated", "with", "early", "target", "vessel", "reocclusion", "or", "luminal", "renarrowing", "after", "coronary", "intervention", "in", "acute", "coronary", "syndromes", "(", "ACS", ")", ".", "In", "an", "observational", "prospective", "study", "we", "investigated", "161", "patients", "with", "ACS", "(", "acute", "myocardial", "infarction", "and", "unstable", "angina", ")", "submitted", "to", "PTCA", ".", "In", "140", "patients", "a", "follow", "-", "up", "angiography", "after", "10", "days", "was", "obtained", ".", "All", "angiograms", "were", "quantitatively", "evaluated", "by", "computerized", "measurements", ".", "Target", "vessel", "reocclusion", "and", "early", "luminal", "renarrowing", "was", "observed", "in", "10", "patients", "(", "7.1", "%", ")", "and", "19", "patients", "(", "13.6", "%", ")", ",", "respectively", ".", "Using", "univariate", "analysis", ",", "significant", "risk", "factors", "(", "P", "0.05", ")", "for", "early", "reocclusion", "and", "renarrowing", "were", "diabetes", "mellitus", "(", "relative", "risk", "[", "RR", "]", "6.1", "and", "5.0", ")", ",", "arterial", "hypertension", "(", "RR", "7.7", "and", "3.3", ")", ",", "postprocedural", "lesion", "length", ">", "=", "2", ".", "5", "mm", "(", "RR", "6.8", "and", "7.1", ")", ",", "postprocedural", "minimal", "lumen", "diameter", "=", "2", ".", "5", "mm", "(", "RR9.0", "and", "5.8", ")", ",", "residual", "stenosis", ">", "=", "25", "%", "(", "RR", "4.8", "and", "3.5", ")", "and", "absence", "of", "stents", "(", "RR", "4.1", "and", "3.2", ")", ".", "Moreover", ",", "in", "multivariate", "analysis", "hypertension", "and", "postprocedural", "lesion", "length", "could", "be", "identified", "as", "independent", "risk", "factors", "for", "reocclusion", "and", "renarrowing", ".", "Diabetes", "mellitus", "was", "found", "to", "be", "an", "independent", "risk", "factor", "for", "renarrowing", ".", "Conclusions", ":", "In", "a", "consecutive", "series", "of", "patients", "with", "ACS", "undergoing", "PTCA", "with", "provisional", "stenting", "the", "occurrence", "of", "early", "target", "vessel", "reocclusion", "and", "luminal", "renarrowing", "is", "lower", "than", "previously", "reported", "for", "this", "subset", "of", "patients", "treated", "by", "PTCA", "alone", ".", "Adverse", "outcome", "is", "related", "to", "absence", "of", "stents", ",", "angiographic", "factors", "(", "residual", "stenosis", ",", "lesion", "length", ",", "minimal", "lumen", "diameter", "after", "procedure", ")", "and", "patient", "-", "related", "factors", "such", "as", "diabetes", "and", "hypertension", "." ]	[ "umlsterm" ]
Angioplasty is an umlsterm, syndromes is an umlsterm, vessel is an umlsterm, stent - like is an umlsterm, angioplasty is an umlsterm, PTCA is an umlsterm, vessel is an umlsterm, syndromes is an umlsterm, prospective study is an umlsterm, patients is an umlsterm, myocardial infarction is an umlsterm, unstable angina is an umlsterm, PTCA is an umlsterm, patients is an umlsterm, angiography is an umlsterm, All is an umlsterm, angiograms is an umlsterm, measurements is an umlsterm, vessel is an umlsterm, patients is an umlsterm, patients is an umlsterm, analysis is an umlsterm, risk factors is an umlsterm, diabetes mellitus is an umlsterm, relative risk is an umlsterm, hypertension is an umlsterm, stenosis is an umlsterm, stents is an umlsterm, multivariate analysis is an umlsterm, hypertension is an umlsterm, risk factors is an umlsterm, Diabetes is an umlsterm, risk factor is an umlsterm, patients is an umlsterm, PTCA is an umlsterm, occurrence is an umlsterm, vessel is an umlsterm, patients is an umlsterm, PTCA is an umlsterm, stents is an umlsterm, stenosis is an umlsterm, procedure is an umlsterm, diabetes is an umlsterm, hypertension is an umlsterm	ZfuerKardiologie.00890485.eng.abstr_task1	Sentence: Angioplasty in acute coronary syndromes is complicated by a high rate of early vessel reocclusion and restenosis . Therefore , it is recommended to achieve a " stent-like " result by percutaneous transluminal coronary angioplasty ( PTCA ) or otherwise use coronary stenting ( provisional stenting ) . This study sought to determine angiographic and patient-related factors that are associated with early target vessel reocclusion or luminal renarrowing after coronary intervention in acute coronary syndromes ( ACS ) . In an observational prospective study we investigated 161 patients with ACS ( acute myocardial infarction and unstable angina ) submitted to PTCA . In 140 patients a follow-up angiography after 10 days was obtained . All angiograms were quantitatively evaluated by computerized measurements . Target vessel reocclusion and early luminal renarrowing was observed in 10 patients ( 7.1% ) and 19 patients ( 13.6% ) , respectively . Using univariate analysis , significant risk factors ( P 0.05 ) for early reocclusion and renarrowing were diabetes mellitus ( relative risk [ RR ] 6.1 and 5.0 ) , arterial hypertension ( RR 7.7 and 3.3 ) , postprocedural lesion length > =2 . 5mm ( RR 6.8 and 7.1 ) , postprocedural minimal lumen diameter =2 . 5 mm ( RR9.0 and 5.8 ) , residual stenosis > =25% ( RR 4.8 and 3.5 ) and absence of stents ( RR 4.1 and 3.2 ) . Moreover , in multivariate analysis hypertension and postprocedural lesion length could be identified as independent risk factors for reocclusion and renarrowing . Diabetes mellitus was found to be an independent risk factor for renarrowing . Conclusions : In a consecutive series of patients with ACS undergoing PTCA with provisional stenting the occurrence of early target vessel reocclusion and luminal renarrowing is lower than previously reported for this subset of patients treated by PTCA alone . Adverse outcome is related to absence of stents , angiographic factors ( residual stenosis , lesion length , minimal lumen diameter after procedure ) and patient-related factors such as diabetes and hypertension . Instructions: please typing these entity words according to sentence: Angioplasty, syndromes, vessel, stent - like, angioplasty, PTCA, vessel, syndromes, prospective study, patients, myocardial infarction, unstable angina, PTCA, patients, angiography, All, angiograms, measurements, vessel, patients, patients, analysis, risk factors, diabetes mellitus, relative risk, hypertension, stenosis, stents, multivariate analysis, hypertension, risk factors, Diabetes, risk factor, patients, PTCA, occurrence, vessel, patients, PTCA, stents, stenosis, procedure, diabetes, hypertension Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Angioplasty in acute coronary syndromes is complicated by a high rate of early vessel reocclusion and restenosis . Therefore , it is recommended to achieve a " stent-like " result by percutaneous transluminal coronary angioplasty ( PTCA ) or otherwise use coronary stenting ( provisional stenting ) . This study sought to determine angiographic and patient-related factors that are associated with early target vessel reocclusion or luminal renarrowing after coronary intervention in acute coronary syndromes ( ACS ) . In an observational prospective study we investigated 161 patients with ACS ( acute myocardial infarction and unstable angina ) submitted to PTCA . In 140 patients a follow-up angiography after 10 days was obtained . All angiograms were quantitatively evaluated by computerized measurements . Target vessel reocclusion and early luminal renarrowing was observed in 10 patients ( 7.1% ) and 19 patients ( 13.6% ) , respectively . Using univariate analysis , significant risk factors ( P 0.05 ) for early reocclusion and renarrowing were diabetes mellitus ( relative risk [ RR ] 6.1 and 5.0 ) , arterial hypertension ( RR 7.7 and 3.3 ) , postprocedural lesion length > =2 . 5mm ( RR 6.8 and 7.1 ) , postprocedural minimal lumen diameter =2 . 5 mm ( RR9.0 and 5.8 ) , residual stenosis > =25% ( RR 4.8 and 3.5 ) and absence of stents ( RR 4.1 and 3.2 ) . Moreover , in multivariate analysis hypertension and postprocedural lesion length could be identified as independent risk factors for reocclusion and renarrowing . Diabetes mellitus was found to be an independent risk factor for renarrowing . Conclusions : In a consecutive series of patients with ACS undergoing PTCA with provisional stenting the occurrence of early target vessel reocclusion and luminal renarrowing is lower than previously reported for this subset of patients treated by PTCA alone . Adverse outcome is related to absence of stents , angiographic factors ( residual stenosis , lesion length , minimal lumen diameter after procedure ) and patient-related factors such as diabetes and hypertension .	[ "Angioplasty", "in", "acute", "coronary", "syndromes", "is", "complicated", "by", "a", "high", "rate", "of", "early", "vessel", "reocclusion", "and", "restenosis", ".", "Therefore", ",", "it", "is", "recommended", "to", "achieve", "a", "\"", "stent", "-", "like", "\"", "result", "by", "percutaneous", "transluminal", "coronary", "angioplasty", "(", "PTCA", ")", "or", "otherwise", "use", "coronary", "stenting", "(", "provisional", "stenting", ")", ".", "This", "study", "sought", "to", "determine", "angiographic", "and", "patient", "-", "related", "factors", "that", "are", "associated", "with", "early", "target", "vessel", "reocclusion", "or", "luminal", "renarrowing", "after", "coronary", "intervention", "in", "acute", "coronary", "syndromes", "(", "ACS", ")", ".", "In", "an", "observational", "prospective", "study", "we", "investigated", "161", "patients", "with", "ACS", "(", "acute", "myocardial", "infarction", "and", "unstable", "angina", ")", "submitted", "to", "PTCA", ".", "In", "140", "patients", "a", "follow", "-", "up", "angiography", "after", "10", "days", "was", "obtained", ".", "All", "angiograms", "were", "quantitatively", "evaluated", "by", "computerized", "measurements", ".", "Target", "vessel", "reocclusion", "and", "early", "luminal", "renarrowing", "was", "observed", "in", "10", "patients", "(", "7.1", "%", ")", "and", "19", "patients", "(", "13.6", "%", ")", ",", "respectively", ".", "Using", "univariate", "analysis", ",", "significant", "risk", "factors", "(", "P", "0.05", ")", "for", "early", "reocclusion", "and", "renarrowing", "were", "diabetes", "mellitus", "(", "relative", "risk", "[", "RR", "]", "6.1", "and", "5.0", ")", ",", "arterial", "hypertension", "(", "RR", "7.7", "and", "3.3", ")", ",", "postprocedural", "lesion", "length", ">", "=", "2", ".", "5", "mm", "(", "RR", "6.8", "and", "7.1", ")", ",", "postprocedural", "minimal", "lumen", "diameter", "=", "2", ".", "5", "mm", "(", "RR9.0", "and", "5.8", ")", ",", "residual", "stenosis", ">", "=", "25", "%", "(", "RR", "4.8", "and", "3.5", ")", "and", "absence", "of", "stents", "(", "RR", "4.1", "and", "3.2", ")", ".", "Moreover", ",", "in", "multivariate", "analysis", "hypertension", "and", "postprocedural", "lesion", "length", "could", "be", "identified", "as", "independent", "risk", "factors", "for", "reocclusion", "and", "renarrowing", ".", "Diabetes", "mellitus", "was", "found", "to", "be", "an", "independent", "risk", "factor", "for", "renarrowing", ".", "Conclusions", ":", "In", "a", "consecutive", "series", "of", "patients", "with", "ACS", "undergoing", "PTCA", "with", "provisional", "stenting", "the", "occurrence", "of", "early", "target", "vessel", "reocclusion", "and", "luminal", "renarrowing", "is", "lower", "than", "previously", "reported", "for", "this", "subset", "of", "patients", "treated", "by", "PTCA", "alone", ".", "Adverse", "outcome", "is", "related", "to", "absence", "of", "stents", ",", "angiographic", "factors", "(", "residual", "stenosis", ",", "lesion", "length", ",", "minimal", "lumen", "diameter", "after", "procedure", ")", "and", "patient", "-", "related", "factors", "such", "as", "diabetes", "and", "hypertension", "." ]	[ "umlsterm" ]

Androgenablation is an umlsterm, therapy is an umlsterm, choice is an umlsterm, treatment is an umlsterm, metastatic is an umlsterm, prostate cancer is an umlsterm, patients is an umlsterm, disease is an umlsterm, androgenablation is an umlsterm, castration is an umlsterm, apoptotic is an umlsterm, treatment is an umlsterm, quality of life is an umlsterm, patients is an umlsterm, toxicity is an umlsterm, treatment costs is an umlsterm, tumor is an umlsterm, survival is an umlsterm, clinical trials is an umlsterm

DerUrologeA.80370153.eng.abstr_task1

Sentence: Androgenablation is the therapy of choice for the treatment of advanced and metastatic prostate cancer . However , in more than half of the patients the disease will ultimately progress within 2 years . Intermittent androgenablation through medical castration maintains the apoptotic potential . By periodically changing phases on and off treatment the quality of life of the patients is improved . Apart from reduced toxicity treatment costs are lowered and tumor progression is possibly delayed . In how far survival is influenced is presently not clear and remains to be evaluated in further clinical trials . Instructions: please typing these entity words according to sentence: Androgenablation, therapy, choice, treatment, metastatic, prostate cancer, patients, disease, androgenablation, castration, apoptotic, treatment, quality of life, patients, toxicity, treatment costs, tumor, survival, clinical trials Options: umlsterm

[ "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

Androgenablation is the therapy of choice for the treatment of advanced and metastatic prostate cancer . However , in more than half of the patients the disease will ultimately progress within 2 years . Intermittent androgenablation through medical castration maintains the apoptotic potential . By periodically changing phases on and off treatment the quality of life of the patients is improved . Apart from reduced toxicity treatment costs are lowered and tumor progression is possibly delayed . In how far survival is influenced is presently not clear and remains to be evaluated in further clinical trials .

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[ "umlsterm" ]

Androgenablation, therapy, choice, treatment, metastatic, prostate cancer, patients, disease, androgenablation, castration, apoptotic, treatment, quality of life, patients, toxicity, treatment costs, tumor, survival, clinical trials

DerUrologeA.80370153.eng.abstr_task2

Sentence: Androgenablation is the therapy of choice for the treatment of advanced and metastatic prostate cancer . However , in more than half of the patients the disease will ultimately progress within 2 years . Intermittent androgenablation through medical castration maintains the apoptotic potential . By periodically changing phases on and off treatment the quality of life of the patients is improved . Apart from reduced toxicity treatment costs are lowered and tumor progression is possibly delayed . In how far survival is influenced is presently not clear and remains to be evaluated in further clinical trials . Instructions: please extract entity words from the input sentence

[ "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]

Androgenablation is the therapy of choice for the treatment of advanced and metastatic prostate cancer . However , in more than half of the patients the disease will ultimately progress within 2 years . Intermittent androgenablation through medical castration maintains the apoptotic potential . By periodically changing phases on and off treatment the quality of life of the patients is improved . Apart from reduced toxicity treatment costs are lowered and tumor progression is possibly delayed . In how far survival is influenced is presently not clear and remains to be evaluated in further clinical trials .

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[ "umlsterm" ]

Significant is a Qualifier, motor complication is a Condition, Drugs is a Drug, acetylcholine is a Drug

NCT03011476_exc_task0

Sentence: Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Condition, Qualifier, Drug

[ "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "O", "O", "B-Drug", "O", "O" ]

Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism

[ "Significant", "motor", "complication", "affecting", "daily", "activities", "\n", "Drugs", "related", "to", "acetylcholine", "metabolism", "\n" ]

[ "Qualifier", "Condition", "Drug" ]

Significant is a Qualifier, motor complication is a Condition, Drugs is a Drug, acetylcholine is a Drug

NCT03011476_exc_task1

Sentence: Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism Instructions: please typing these entity words according to sentence: Significant, motor complication, Drugs, acetylcholine Options: Condition, Qualifier, Drug

[ "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "O", "O", "B-Drug", "O", "O" ]

Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism

[ "Significant", "motor", "complication", "affecting", "daily", "activities", "\n", "Drugs", "related", "to", "acetylcholine", "metabolism", "\n" ]

[ "Qualifier", "Condition", "Drug" ]

Significant, motor complication, Drugs, acetylcholine

NCT03011476_exc_task2

Sentence: Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism Instructions: please extract entity words from the input sentence

[ "B-Qualifier", "B-Condition", "I-Condition", "O", "O", "O", "O", "B-Drug", "O", "O", "B-Drug", "O", "O" ]

Significant motor complication affecting daily activities Drugs related to acetylcholine metabolism

[ "Significant", "motor", "complication", "affecting", "daily", "activities", "\n", "Drugs", "related", "to", "acetylcholine", "metabolism", "\n" ]

[ "Qualifier", "Condition", "Drug" ]

Osteomyelitis is an umlsterm, infection is an umlsterm, bone marrow is an umlsterm, osteomyelitis is an umlsterm, form is an umlsterm, Mycobacterium tuberculosis is an umlsterm, infection is an umlsterm, form is an umlsterm, children is an umlsterm, adults is an umlsterm, tibia is an umlsterm, femur is an umlsterm, tuberculosis is an umlsterm, osteomyelitis is an umlsterm, osteomyelitis is an umlsterm, viruses is an umlsterm, fungi is an umlsterm, echinococcus is an umlsterm, osteomyelitis is an umlsterm, osteomyelitis is an umlsterm, abscess is an umlsterm, leucocytes is an umlsterm, granulation tissue is an umlsterm, bone is an umlsterm, tuberculosis is an umlsterm, granulomas is an umlsterm, necrosis is an umlsterm, epithelioid cells is an umlsterm, giant cells is an umlsterm, forms is an umlsterm, osteomyelitis is an umlsterm, antibiotics is an umlsterm, complications is an umlsterm, secondary is an umlsterm, form is an umlsterm

DerRadiologe.60360781.eng.abstr_task0

Sentence: Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form .

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[ "umlsterm" ]

Osteomyelitis is an umlsterm, infection is an umlsterm, bone marrow is an umlsterm, osteomyelitis is an umlsterm, form is an umlsterm, Mycobacterium tuberculosis is an umlsterm, infection is an umlsterm, form is an umlsterm, children is an umlsterm, adults is an umlsterm, tibia is an umlsterm, femur is an umlsterm, tuberculosis is an umlsterm, osteomyelitis is an umlsterm, osteomyelitis is an umlsterm, viruses is an umlsterm, fungi is an umlsterm, echinococcus is an umlsterm, osteomyelitis is an umlsterm, osteomyelitis is an umlsterm, abscess is an umlsterm, leucocytes is an umlsterm, granulation tissue is an umlsterm, bone is an umlsterm, tuberculosis is an umlsterm, granulomas is an umlsterm, necrosis is an umlsterm, epithelioid cells is an umlsterm, giant cells is an umlsterm, forms is an umlsterm, osteomyelitis is an umlsterm, antibiotics is an umlsterm, complications is an umlsterm, secondary is an umlsterm, form is an umlsterm

DerRadiologe.60360781.eng.abstr_task1

Sentence: Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form . Instructions: please typing these entity words according to sentence: Osteomyelitis, infection, bone marrow, osteomyelitis, form, Mycobacterium tuberculosis, infection, form, children, adults, tibia, femur, tuberculosis, osteomyelitis, osteomyelitis, viruses, fungi, echinococcus, osteomyelitis, osteomyelitis, abscess, leucocytes, granulation tissue, bone, tuberculosis, granulomas, necrosis, epithelioid cells, giant cells, forms, osteomyelitis, antibiotics, complications, secondary, form Options: umlsterm

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Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form .

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[ "umlsterm" ]

Osteomyelitis, infection, bone marrow, osteomyelitis, form, Mycobacterium tuberculosis, infection, form, children, adults, tibia, femur, tuberculosis, osteomyelitis, osteomyelitis, viruses, fungi, echinococcus, osteomyelitis, osteomyelitis, abscess, leucocytes, granulation tissue, bone, tuberculosis, granulomas, necrosis, epithelioid cells, giant cells, forms, osteomyelitis, antibiotics, complications, secondary, form

DerRadiologe.60360781.eng.abstr_task2

Sentence: Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form . Instructions: please extract entity words from the input sentence

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Osteomyelitis is an infection of the bone marrow caused by both non-specific and specific agents . Non-specific endogenic osteomyelitis represents the most frequent form , followed by the specific form caused by Mycobacterium tuberculosis infection . Typically , the non-specific form occurs in children and young adults , and the sites most frequently affected are the distal and the proximal ends of the tibia and femur . In tuberculosis , osteomyelitis is predominantly located in the vertebral bodies . In rare cases osteomyelitis can be caused by viruses , fungi or echinococcus . It may also occur as so-called acute endogenic osteomyelitis , such as plasmocellular osteomyelitis and Brodie's abscess . Histologically , dense infiltration of leucocytes , granulation tissue and bone sequesters can be seen . In tuberculosis granulomas with central necrosis , epithelioid cells and giant cells of Langhans type are characteristically found . Most forms of acute osteomyelitis can be successfully treated with antibiotics , leading to complete healing without complications . Only a few reported cases develop into a secondary , chronic form .

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sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, malignidad is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA

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Sentence: Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MORFOLOGIA_NEOPLASIA

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Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo.

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[ "MORFOLOGIA_NEOPLASIA" ]

sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, malignidad is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA, sinovitis villonodular pigmentada is a MORFOLOGIA_NEOPLASIA

539_task1

Sentence: Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo. Instructions: please typing these entity words according to sentence: sinovitis villonodular pigmentada, malignidad, sinovitis villonodular pigmentada, sinovitis villonodular pigmentada, sinovitis villonodular pigmentada Options: MORFOLOGIA_NEOPLASIA

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Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo.

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[ "MORFOLOGIA_NEOPLASIA" ]

sinovitis villonodular pigmentada, malignidad, sinovitis villonodular pigmentada, sinovitis villonodular pigmentada, sinovitis villonodular pigmentada

539_task2

Sentence: Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo. Instructions: please extract entity words from the input sentence

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Anamnesis Presentamos el caso de un paciente de 37 años, sin alergias medicamentosas conocidas ni hábitos tóxicos intervenido en el año 2007 de una rotura del ligamento cruzado anterior en la rodilla izquierda como consecuencia de una lesión deportiva. En el año 2011, el paciente presentó un cuadro de inflamación articular de rodilla izquierda, doloroso y con leve impotencia funcional por el cual consultó con su traumatólogo y, tras la realización de una resonancia magnética (RM), en el año 2012, fue diagnosticado de sinovitis crónica. Ante la ausencia de mejora clínica, en febrero de 2013, se decidió realizar una artroscopia diagnóstica y terapéutica y se obtuvo un resultado anatomopatológico compatible con sinovitis villonodular pigmentada. Tras el diagnóstico, el paciente siguió tratamiento con antiinflamatorios, corticoides sistémicos vía oral y se le realizaron artrocentesis sucesivas evacuadoras. En diciembre de 2015, se realizó una sinovectomía cerrada y el diagnóstico anatomopatológico fue negativo para malignidad. No obstante, ante el empeoramiento clínico del paciente que presentaba inflamación de la articulación con imposibilidad para realizar sus actividades habituales se solicitó nueva RM en febrero de 2017 que mostraba la presencia de enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina compatible con sinovitis villonodular pigmentada. Fue derivado a consultas de Oncología Médica para valoración de tratamiento sistémico. Exploración física En consultas de Oncología: paciente consciente y orientado, normocoloreado, normohidratado. En la auscultación pulmonar se aprecia normofonesis en todos los campos, no se auscultan roncus ni sibilancias. En la auscultación cardiaca no se auscultan soplos ni extratonos. Los latidos son rítmicos a una frecuencia de 65 lpm aproximadamente. El abdomen es blando, depresible, no doloroso en la palpación. No se aprecian masas ni megalias. Los ruidos peristálticos son normales. Durante la exploración de las extremidades inferiores, se aprecia inflamación articular en rodilla izquierda, con dolor a la flexión activa y pasiva. La fuerza y la sensibilidad están conservadas en ambas extremidades inferiores, presentando el paciente impotencia para la flexión total de la rodilla izquierda por inflamación y dolor. La exploración neurológica no reveló alteraciones de pares craneales ni déficits motores ni sensitivos. Pruebas complementarias Resonancia magnética nuclear año 2012: sinovitis crónica con detritus y pannus en su interior. Informe anatomopatológico tras artroscopia diagnóstica y terapéutica (mayo de 2013): Proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas alternando con fagocitos que contienen hemosiderina. Hallazgos compatibles con sinovitis villonodular pigmentada. En el año 2015, se realizó una gammagrafía ósea de control que muestra notable hipercaptación ósea en caras articulares de rodilla izquierda con aumento del pool vascular que sobrepasa estructuras óseas. Compatible con osteopatía y sinovitis asociada. RM febrero de 2017: enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina. Tras estos hallazgos, el paciente es derivado a consultas de Oncología médica e inicia tratamiento sistémico con imatinib. En la RM junio 2017 se apreciaba la persistencia de realce sinovial difuso, pero era menos evidente la presencia de zonas nodulares asociadas que se identificaban en región retro patelar y receso femoral lateral. Por tanto, los hallazgos radiológicos indicaban cierto grado de respuesta parcial. En la RM de noviembre 2017 se observó una reducción franca del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y disminución del grado de realce, todo ello sugestivo de buena respuesta al tratamiento. En la resonancia magnética de abril de 2018 no se aprecian cambios significativos respecto a los estudios previos, lo cual indica que existe una estabilización de la enfermedad. En la última resonancia magnética, realizada en marzo de 2019 se observan áreas de engrosamiento sinovial con depósitos de hemosiderina que no han variado respecto al último estudio. Se aprecia área de edema medular óseo subcondral en cóndilo femoral interno acorde con fractura de estrés en zona de carga. En cuanto a estudios analíticos, se han realizado a lo largo del seguimiento en consultas de Oncología sucesivos controles que incluían bioquímica básica, perfil tiroideo, perfil hepático y hemograma. Únicamente cabe destacar una elevación de transaminasas (GOT 89 UI/l y GGT de 113 UI/l), sin elevación de bilirrubina total ni directa, en noviembre de 2017. El resto de las determinaciones analíticas no ha mostrado alteraciones durante el seguimiento. Diagnóstico El diagnóstico de la enfermedad se lleva a cabo mediante pruebas de imagen que permitan estudiar de manera detallada los tejidos blandos, por lo que se recomienda la resonancia magnética. Además, se debe completar el estudio con pruebas histológicas que confirmen el diagnóstico. En nuestro caso, las pruebas diagnósticas que confirmaron el diagnóstico fueron: » Artroscopia diagnóstica en 2013 a partir de la cual se obtuvo el siguiente resultado anatomopatológico: proliferación papilar de revestimiento sinovial por debajo de la cual se observa una proliferación de histiocitos y células gigantes multinucleadas, alternando con fagocitos que contienen hemosiderina. » La prueba de imagen realizada en el año 2012 (RM) no confirmaba el diagnóstico, sino que orientaba a una sinovitis crónica. No fue hasta 2017 cuando en una nueva RM se observó enfermedad sinovial difusa con derrame articular y engrosamiento de la sinovial, con depósitos de hemosiderina, todo ello compatible con el diagnóstico de sinovitis villonodular pigmentada. Tratamiento Desde el inicio del cuadro, el paciente ha requerido tratamiento analgésico, por lo general con AINE (dexketoprofeno), con control parcial del dolor, pero sin haber tenido necesidad de hacer uso de analgésicos de segundo o tercer escalón según escala de la Organización Mundial de la Salud (OMS) ni de otros coadyuvantes. Además, el paciente ha recibido corticoides (metilprednisolona) vía oral para reducir la inflamación articular. En abril de 2017, el paciente inició tratamiento con imatinib mesilato a dosis de 400 mg al día vía oral. Tras presentar aftas bucales y mucositis grado 2, se decidió reducir la dosis de imatinib a 300 mg al día vía oral con buena tolerancia sin necesidad de nuevas reducciones de dosis. Evolución En resonancia magnética realizada en junio de 2017, se apreció una respuesta parcial de la enfermedad. Tras dos meses de tratamiento, el paciente presentó aftas bucales dolorosas, por lo que se decidió reducir la dosis de imatinib a 300 mg diarios. En resonancia magnética de noviembre de 2017 se aprecia clara mejoría radiológica, con marcada reducción del derrame articular, del tamaño del paño sinovítico (sobre todo en zona infrapatelar) y reducción del grado de realce. En el mismo mes, tras solicitud de análisis de control se apreció una elevación de transaminasas con GOT de 89 UI/l y GPT de 113 UI/l, permaneciendo el paciente asintomático. No se detectó elevación de bilirrubina. Se decidió continuar con la misma pauta de imatinib y realizar controles analíticos periódicos observando a las tres semanas una normalización de las cifras de transaminasas. El paciente actualmente refiere una clara mejoría clínica y en las pruebas radiológicas es evidente una buena respuesta al tratamiento. A pesar de ello, el paciente no ha podido reanudar la actividad que realizaba previamente, puesto que, en la resonancia magnética de marzo de 2019, se observa la presencia de pequeña fractura de estrés y edema en cóndilo interno de fémur en zona de carga, por lo que se le recomienda reposo relativo.

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"sugestivo", "de", "buena", "respuesta", "al", "tratamiento", ".", "\n", "En", "la", "resonancia", "magnética", "de", "abril", "de", "2018", "no", "se", "aprecian", "cambios", "significativos", "respecto", "a", "los", "estudios", "previos", ",", "lo", "cual", "indica", "que", "existe", "una", "estabilización", "de", "la", "enfermedad", ".", "\n", "En", "la", "última", "resonancia", "magnética", ",", "realizada", "en", "marzo", "de", "2019", "se", "observan", "áreas", "de", "engrosamiento", "sinovial", "con", "depósitos", "de", "hemosiderina", "que", "no", "han", "variado", "respecto", "al", "último", "estudio", ".", "Se", "aprecia", "área", "de", "edema", "medular", "óseo", "subcondral", "en", "cóndilo", "femoral", "interno", "acorde", "con", "fractura", "de", "estrés", "en", "zona", "de", "carga", ".", "\n", "En", "cuanto", "a", "estudios", "analíticos", ",", "se", "han", "realizado", "a", "lo", "largo", "del", "seguimiento", "en", "consultas", "de", "Oncología", "sucesivos", "controles", "que", "incluían", "bioquímica", "básica", ",", "perfil", "tiroideo", ",", "perfil", "hepático", "y", "hemograma", ".", "\n", "Únicamente", "cabe", "destacar", "una", "elevación", "de", "transaminasas", "(", "GOT", "89", "UI", "/", "l", "y", "GGT", "de", "113", "UI", "/", "l", ")", ",", "sin", "elevación", "de", "bilirrubina", "total", "ni", "directa", ",", "en", "noviembre", "de", "2017", ".", "El", "resto", "de", "las", "determinaciones", "analíticas", "no", "ha", "mostrado", "alteraciones", "durante", "el", "seguimiento", ".", "\n\n", "Diagnóstico", "\n", "El", "diagnóstico", "de", "la", "enfermedad", "se", "lleva", "a", "cabo", "mediante", "pruebas", "de", "imagen", "que", "permitan", "estudiar", "de", "manera", "detallada", "los", "tejidos", "blandos", ",", "por", "lo", "que", "se", "recomienda", "la", "resonancia", "magnética", ".", "Además", ",", "se", "debe", "completar", "el", "estudio", "con", "pruebas", "histológicas", "que", "confirmen", "el", "diagnóstico", ".", "\n", "En", "nuestro", "caso", ",", "las", "pruebas", "diagnósticas", "que", "confirmaron", "el", "diagnóstico", "fueron", ":", "\n", "»", "Artroscopia", "diagnóstica", "en", "2013", "a", "partir", "de", "la", "cual", "se", "obtuvo", "el", "siguiente", "resultado", "anatomopatológico", ":", "proliferación", "papilar", "de", "revestimiento", "sinovial", "por", "debajo", "de", "la", "cual", "se", "observa", "una", "proliferación", "de", "histiocitos", "y", "células", "gigantes", "multinucleadas", ",", "alternando", "con", "fagocitos", "que", "contienen", "hemosiderina", ".", "\n", "»", "La", "prueba", "de", "imagen", "realizada", "en", "el", "año", "2012", "(", "RM", ")", "no", "confirmaba", "el", "diagnóstico", ",", "sino", "que", "orientaba", "a", "una", "sinovitis", "crónica", ".", "No", "fue", "hasta", "2017", "cuando", "en", "una", "nueva", "RM", "se", "observó", "enfermedad", "sinovial", "difusa", "con", "derrame", "articular", "y", "engrosamiento", "de", "la", "sinovial", ",", "con", "depósitos", "de", "hemosiderina", ",", "todo", "ello", "compatible", "con", "el", "diagnóstico", "de", "sinovitis", "villonodular", "pigmentada", ".", "\n\n", "Tratamiento", "\n", "Desde", "el", "inicio", "del", "cuadro", ",", "el", "paciente", "ha", "requerido", "tratamiento", "analgésico", ",", "por", "lo", "general", "con", "AINE", "(", "dexketoprofeno", ")", ",", "con", "control", "parcial", "del", "dolor", ",", "pero", "sin", "haber", "tenido", "necesidad", "de", "hacer", "uso", "de", "analgésicos", "de", "segundo", "o", "tercer", "escalón", "según", "escala", "de", "la", "Organización", "Mundial", "de", "la", "Salud", "(", "OMS", ")", "ni", "de", "otros", "coadyuvantes", ".", "\n", "Además", ",", "el", "paciente", "ha", "recibido", "corticoides", "(", "metilprednisolona", ")", "vía", "oral", "para", "reducir", "la", "inflamación", "articular", ".", "\n", "En", "abril", "de", "2017", ",", "el", "paciente", "inició", "tratamiento", "con", "imatinib", "mesilato", "a", "dosis", "de", "400", "mg", "al", "día", "vía", "oral", ".", "Tras", "presentar", "aftas", "bucales", "y", "mucositis", "grado", "2", ",", "se", "decidió", "reducir", "la", "dosis", "de", "imatinib", "a", "300", "mg", "al", "día", "vía", "oral", "con", "buena", "tolerancia", "sin", "necesidad", "de", "nuevas", "reducciones", "de", "dosis", ".", "\n\n", "Evolución", "\n", "En", "resonancia", "magnética", "realizada", "en", "junio", "de", "2017", ",", "se", "apreció", "una", "respuesta", "parcial", "de", "la", "enfermedad", ".", "\n", "Tras", "dos", "meses", "de", "tratamiento", ",", "el", "paciente", "presentó", "aftas", "bucales", "dolorosas", ",", "por", "lo", "que", "se", "decidió", "reducir", "la", "dosis", "de", "imatinib", "a", "300", "mg", "diarios", ".", "\n", "En", "resonancia", "magnética", "de", "noviembre", "de", "2017", "se", "aprecia", "clara", "mejoría", "radiológica", ",", "con", "marcada", "reducción", "del", "derrame", "articular", ",", "del", "tamaño", "del", "paño", "sinovítico", "(", "sobre", "todo", "en", "zona", "infrapatelar", ")", "y", "reducción", "del", "grado", "de", "realce", ".", "\n", "En", "el", "mismo", "mes", ",", "tras", "solicitud", "de", "análisis", "de", "control", "se", "apreció", "una", "elevación", "de", "transaminasas", "con", "GOT", "de", "89", "UI", "/", "l", "y", "GPT", "de", "113", "UI", "/", "l", ",", "permaneciendo", "el", "paciente", "asintomático", ".", "No", "se", "detectó", "elevación", "de", "bilirrubina", ".", "Se", "decidió", "continuar", "con", "la", "misma", "pauta", "de", "imatinib", "y", "realizar", "controles", "analíticos", "periódicos", "observando", "a", "las", "tres", "semanas", "una", "normalización", "de", "las", "cifras", "de", "transaminasas", ".", "\n", "El", "paciente", "actualmente", "refiere", "una", "clara", "mejoría", "clínica", "y", "en", "las", "pruebas", "radiológicas", "es", "evidente", "una", "buena", "respuesta", "al", "tratamiento", ".", "A", "pesar", "de", "ello", ",", "el", "paciente", "no", "ha", "podido", "reanudar", "la", "actividad", "que", "realizaba", "previamente", ",", "puesto", "que", ",", "en", "la", "resonancia", "magnética", "de", "marzo", "de", "2019", ",", "se", "observa", "la", "presencia", "de", "pequeña", "fractura", "de", "estrés", "y", "edema", "en", "cóndilo", "interno", "de", "fémur", "en", "zona", "de", "carga", ",", "por", "lo", "que", "se", "le", "recomienda", "reposo", "relativo", "." ]

[ "MORFOLOGIA_NEOPLASIA" ]

Callus is an umlsterm, treatment is an umlsterm, May is an umlsterm, patients is an umlsterm, osteotomy is an umlsterm, haloborne is an umlsterm, patients is an umlsterm, patients is an umlsterm, edentulous is an umlsterm, upper jaw is an umlsterm, velopharyngeal insufficiency is an umlsterm, patient is an umlsterm, patients is an umlsterm, pain is an umlsterm, soft palate is an umlsterm, Follow - up studies is an umlsterm, edentulous is an umlsterm, patients is an umlsterm, Callus is an umlsterm, surgery is an umlsterm

MundKieferGesichtschirurgie.0004s442.eng.abstr_task0

Sentence: Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases .

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[ "umlsterm" ]

Callus is an umlsterm, treatment is an umlsterm, May is an umlsterm, patients is an umlsterm, osteotomy is an umlsterm, haloborne is an umlsterm, patients is an umlsterm, patients is an umlsterm, edentulous is an umlsterm, upper jaw is an umlsterm, velopharyngeal insufficiency is an umlsterm, patient is an umlsterm, patients is an umlsterm, pain is an umlsterm, soft palate is an umlsterm, Follow - up studies is an umlsterm, edentulous is an umlsterm, patients is an umlsterm, Callus is an umlsterm, surgery is an umlsterm

MundKieferGesichtschirurgie.0004s442.eng.abstr_task1

Sentence: Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases . Instructions: please typing these entity words according to sentence: Callus, treatment, May, patients, osteotomy, haloborne, patients, patients, edentulous, upper jaw, velopharyngeal insufficiency, patient, patients, pain, soft palate, Follow - up studies, edentulous, patients, Callus, surgery Options: umlsterm

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Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases .

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[ "umlsterm" ]

Callus, treatment, May, patients, osteotomy, haloborne, patients, patients, edentulous, upper jaw, velopharyngeal insufficiency, patient, patients, pain, soft palate, Follow - up studies, edentulous, patients, Callus, surgery

MundKieferGesichtschirurgie.0004s442.eng.abstr_task2

Sentence: Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases . Instructions: please extract entity words from the input sentence

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Callus distraction in the treatment of severe midfacial hypoplasia/atrophy may offer new therapeutical possibilities . Between May 1998 and March 1999 , six patients underwent a subtotal Le Fort I-II osteotomy with subsequent distraction via a haloborne distractor ( RED ) . Five patients suffered from CLP , four patients were totally or almost edentulous in the upper jaw . Corrections of sagittal discrepancies were possible in all cases ( distraction 16-31 mm ) . No case of increased velopharyngeal insufficiency was seen . In one patient the halo had to be refixed . Three patients suffered from tension-like pain in the soft palate during distraction . Follow-up studies suggest the necessity for overcorrection of 20% in edentulous senior patients . Callus midfacial distraction is a promising new alternative to conventional orthognathic surgery in severe cases .

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[ "umlsterm" ]

aspartate is a Entity, coagulation factors IX is a Protein, EGF - like modules is a Entity, coagulation factors IX is a Protein, X is a Protein, factor X is a Protein, factor IX is a Protein, factor X is a Protein, factor IX is a Protein

548_task0

Sentence: The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

[ "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding.

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[ "Protein", "Entity" ]

aspartate is a Entity, coagulation factors IX is a Protein, EGF - like modules is a Entity, coagulation factors IX is a Protein, X is a Protein, factor X is a Protein, factor IX is a Protein, factor X is a Protein, factor IX is a Protein

548_task1

Sentence: The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding. Instructions: please typing these entity words according to sentence: aspartate, coagulation factors IX, EGF - like modules, coagulation factors IX, X, factor X, factor IX, factor X, factor IX Options: Entity, Protein

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The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding.

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[ "Protein", "Entity" ]

aspartate, coagulation factors IX, EGF - like modules, coagulation factors IX, X, factor X, factor IX, factor X, factor IX

548_task2

Sentence: The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding. Instructions: please extract entity words from the input sentence

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The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X. Hydroxylation of aspartic acid to erythro-beta-aspartic acid (Hya) occurs in epidermal growth factor (EGF)-like modules in numerous extracellular proteins with diverse functions. Several EGF-like modules with the consensus sequence for hydroxylation bind Ca2+, and it has therefore been suggested that the hydroxyl group is essential for Ca2+ binding. To determine directly the influence of beta-hydroxylation on calcium binding in the EGF-like modules from coagulation factors IX and X, we have now measured calcium binding to both the fully beta-hydroxylated and the non-beta-hydroxylated modules of the two proteins. At low ionic strength, the Hya-containing module of factor X has a slightly higher Ca2+ affinity, but at physiological salt concentrations this difference is no longer significant for either factor IX or X. Analysis of the 1H NMR chemical shift differences between the hydroxylated and nonhydroxylated factor X modules show that hydroxylation has no effect on the domain fold. Furthermore, measurements on factor IX show that hydroxylation has no effect on the Ca2+/Mg2+ specificity of the ion binding site. We conclude that the hydroxyl group is not a direct ligand for the calcium ion in these EGF-like modules, nor is it essential for high-affinity Ca2+ binding.

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[ "Protein", "Entity" ]

Patienten is an umlsterm, Operationsmethode is an umlsterm, Rezidivleisten- is an umlsterm, Rezidivraten is an umlsterm, Rezidivoperationen is an umlsterm, Operationsmorbiditaet is an umlsterm, Langzeitkomplikationen is an umlsterm, Patienten is an umlsterm, Arbeitsplatz is an umlsterm

DerChirurg.70680970.ger.abstr_task0

Sentence: Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren .

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[ "umlsterm" ]

Patienten is an umlsterm, Operationsmethode is an umlsterm, Rezidivleisten- is an umlsterm, Rezidivraten is an umlsterm, Rezidivoperationen is an umlsterm, Operationsmorbiditaet is an umlsterm, Langzeitkomplikationen is an umlsterm, Patienten is an umlsterm, Arbeitsplatz is an umlsterm

DerChirurg.70680970.ger.abstr_task1

Sentence: Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren . Instructions: please typing these entity words according to sentence: Patienten, Operationsmethode, Rezidivleisten-, Rezidivraten, Rezidivoperationen, Operationsmorbiditaet, Langzeitkomplikationen, Patienten, Arbeitsplatz Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren .

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[ "umlsterm" ]

Patienten, Operationsmethode, Rezidivleisten-, Rezidivraten, Rezidivoperationen, Operationsmorbiditaet, Langzeitkomplikationen, Patienten, Arbeitsplatz

DerChirurg.70680970.ger.abstr_task2

Sentence: Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren . Instructions: please extract entity words from the input sentence

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Zusammenfassung . Eine 8 jaehrige Erfahrung ( 1989-1996 ) an ueber 3.000 Patienten laesst erkennen , dass die PerFix-Netzplomben-Hernioplastik eine einfache Operationsmethode darstellt und in standardisierter Form eingesetzt werden kann , um praktisch alle primaeren oder Rezidivleisten- oder Femoralhernien zu behandeln . Die Rezidivraten bleiben annehmbar niedrig ( 1 % bei primaeren und 2 % bei Rezidivoperationen ) und , was am wichtigsten ist , die Operationsmorbiditaet und die Kurz- und Langzeitkomplikationen werden im wesentlichen vermieden . Als unmittelbare Folge sind die Patienten sofort in der Lage , ihre normalen taeglichen Aktivitaeten wiederaufzunehmen und rasch an ihren Arbeitsplatz zurueckzukehren .

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[ "umlsterm" ]

muscle is a Organ, muscle is a Organ, breast muscle is a Organ, breast muscle is a Organ, muscle is a Organ, sarcomere is a Tissue, sarcomere is a Tissue, sarcomere is a Tissue

PMID-2704697_task0

Sentence: Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Tissue, Organ

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Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development.

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[ "Organ", "Tissue" ]

muscle is a Organ, muscle is a Organ, breast muscle is a Organ, breast muscle is a Organ, muscle is a Organ, sarcomere is a Tissue, sarcomere is a Tissue, sarcomere is a Tissue

PMID-2704697_task1

Sentence: Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development. Instructions: please typing these entity words according to sentence: muscle, muscle, breast muscle, breast muscle, muscle, sarcomere, sarcomere, sarcomere Options: Tissue, Organ

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Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development.

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[ "Organ", "Tissue" ]

muscle, muscle, breast muscle, breast muscle, muscle, sarcomere, sarcomere, sarcomere

PMID-2704697_task2

Sentence: Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development. Instructions: please extract entity words from the input sentence

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Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. Three experiments were conducted to examine the effects of sodium pentobarbital (SP), iodoacetate (IO), tubocurarine (TC), and surgical denervation (DN) on early rigor development in broiler breast muscle. In Experiment 1, birds were either anesthetized or not with SP before receiving an injection of IO or TC or maintained as noninjected controls. Experiment 2 was identical except that a treatment of denervation of the breast muscle was added. Experiment 3 was conducted to contrast birds at 1 day (DN1) and 3 days (DN3) denervation prior to slaughter to nonoperated controls. Measurements of muscle lactate, ATP, R value (ratio of inosine to adenine nucleotides), pH, sarcomere lengths, and shear were used to evaluate treatment effects. Results for Experiment 1 showed no significant differences among treatment and control groups for ATP and lactate contents, R values, or sarcomere lengths; however, significantly lower pH and higher shear values were observed for control birds. In Experiment 2, no significant differences were observed among the treatment groups for ATP, R values, or sarcomere lengths. However, lactate and shear values were significantly lower, and pH higher, for the DN and SP treated birds. Experiment 3 resulted in lower lactate and higher pH values for the DN3 treatment in comparison with both DN1 and control groups. Results of these studies indicate that the use of SP and DN can be used to alter the early profiles of rigor development.

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[ "Organ", "Tissue" ]

carcinoma ductal infiltrante de mama derecha de 3,7 cm , grado histológico II de Nottingham is a MORFOLOGIA_NEOPLASIA, metástasis is a MORFOLOGIA_NEOPLASIA, progresión hepática is a MORFOLOGIA_NEOPLASIA, progresión ósea is a MORFOLOGIA_NEOPLASIA, lesión única de 1 cm en hemisferio is a MORFOLOGIA_NEOPLASIA, lesión cerebelosa is a MORFOLOGIA_NEOPLASIA

365_task0

Sentence: Anamnesis Mujer de 57 años, posmenopáusica, fumadora de 20 cigarrillos/día, sin otros antecedentes personales ni familiares de interés, diagnosticada en Febrero 2012 mediante programa de cribado de un carcinoma ductal infiltrante de mama derecha de 3,7 cm, grado histológico II de Nottingham, RE +++, RP -, HER2 1+, Ki-67 17%. En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: MORFOLOGIA_NEOPLASIA

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Anamnesis Mujer de 57 años, posmenopáusica, fumadora de 20 cigarrillos/día, sin otros antecedentes personales ni familiares de interés, diagnosticada en Febrero 2012 mediante programa de cribado de un carcinoma ductal infiltrante de mama derecha de 3,7 cm, grado histológico II de Nottingham, RE +++, RP -, HER2 1+, Ki-67 17%. En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas.

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[ "MORFOLOGIA_NEOPLASIA" ]

carcinoma ductal infiltrante de mama derecha de 3,7 cm , grado histológico II de Nottingham is a MORFOLOGIA_NEOPLASIA, metástasis is a MORFOLOGIA_NEOPLASIA, progresión hepática is a MORFOLOGIA_NEOPLASIA, progresión ósea is a MORFOLOGIA_NEOPLASIA, lesión única de 1 cm en hemisferio is a MORFOLOGIA_NEOPLASIA, lesión cerebelosa is a MORFOLOGIA_NEOPLASIA

365_task1

Sentence: Anamnesis Mujer de 57 años, posmenopáusica, fumadora de 20 cigarrillos/día, sin otros antecedentes personales ni familiares de interés, diagnosticada en Febrero 2012 mediante programa de cribado de un carcinoma ductal infiltrante de mama derecha de 3,7 cm, grado histológico II de Nottingham, RE +++, RP -, HER2 1+, Ki-67 17%. En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas. Instructions: please typing these entity words according to sentence: carcinoma ductal infiltrante de mama derecha de 3,7 cm , grado histológico II de Nottingham, metástasis, progresión hepática, progresión ósea, lesión única de 1 cm en hemisferio, lesión cerebelosa Options: MORFOLOGIA_NEOPLASIA

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Anamnesis Mujer de 57 años, posmenopáusica, fumadora de 20 cigarrillos/día, sin otros antecedentes personales ni familiares de interés, diagnosticada en Febrero 2012 mediante programa de cribado de un carcinoma ductal infiltrante de mama derecha de 3,7 cm, grado histológico II de Nottingham, RE +++, RP -, HER2 1+, Ki-67 17%. En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas.

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[ "MORFOLOGIA_NEOPLASIA" ]

carcinoma ductal infiltrante de mama derecha de 3,7 cm , grado histológico II de Nottingham, metástasis, progresión hepática, progresión ósea, lesión única de 1 cm en hemisferio, lesión cerebelosa

365_task2

Sentence: Anamnesis Mujer de 57 años, posmenopáusica, fumadora de 20 cigarrillos/día, sin otros antecedentes personales ni familiares de interés, diagnosticada en Febrero 2012 mediante programa de cribado de un carcinoma ductal infiltrante de mama derecha de 3,7 cm, grado histológico II de Nottingham, RE +++, RP -, HER2 1+, Ki-67 17%. En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas. Instructions: please extract entity words from the input sentence

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Anamnesis Mujer de 57 años, posmenopáusica, fumadora de 20 cigarrillos/día, sin otros antecedentes personales ni familiares de interés, diagnosticada en Febrero 2012 mediante programa de cribado de un carcinoma ductal infiltrante de mama derecha de 3,7 cm, grado histológico II de Nottingham, RE +++, RP -, HER2 1+, Ki-67 17%. En el estudio de extensión se objetivan metástasis hepáticas y óseas múltiples; por tanto, estadio IV de inicio. Recibe quimioterapia en 1.ª línea con esquema secuencial doxorrubicina 60 mg/m2 + ciclofosfamida 600 mg/m2 x 4 ciclos + ácido zoledrónico mensual, con buena tolerancia y respuesta parcial hepática, y posterior docetaxel 75 mg/m2 x 8 ciclos, con enfermedad estable, precisando disminución de dosis de un 20% y soporte con factores de crecimiento hematopoyético desde el 3.er ciclo por neutropenia febril grado 4. Se administra hormonoterapia de mantenimiento con letrozol durante 14 meses hasta progresión hepática en marzo de 2014. Se plantea entonces una 2.ª línea de quimioterapia con capecitabina 1.000 mg/m2, con nueva progresión ósea, hepática y cerebelosa (lesión única de 1 cm en hemisferio izquierdo) tras 6 meses de tratamiento. Desde el punto de vista clínico, presenta inestabilidad para la marcha. Se indica corticoterapia a altas dosis y fenitoína profiláctica 300 mg/día, según protocolo del Servicio de Radioterapia. En octubre de 2014 recibe radioterapia (RT) holocraneal 30 Gy en 10 fracciones de 3 Gy + RT estereotáxica 18 G sobre lesión cerebelosa, bien tolerada. En noviembre de 2014 inicia 3.ª línea de quimioterapia con vinorelbina oral 60 mg/m2. Tras 2 ciclos, en pauta descendente de dexametasona, acude a Urgencias con fiebre de 39 ºC de 48 horas de evolución, disnea, dificultad para tragar y exantema generalizado. No presenta cefalea, clínica gastrointestinal, tos, expectoración ni síndrome miccional. Exploración física Mal estado general, taquipneica a 20 rpm, TA 90/60, Tº 39,6 ºC. Saturación basal 91%. Edema de labios y lengua, mucosa friable. Exantema macular eritematoso afectando a cabeza, tórax y abdomen de forma centrípeta, con alguna lesión aislada en miembros; Nikolsky -. < 10% superficie corporal afecta. ACP: taquicárdica, crepitantes base derecha. Sin otros hallazgos relevantes. Pruebas complementarias Ante la clínica aguda de fiebre, disnea y exantema se solicitan pruebas para descartar cuadro séptico de origen respiratorio vs. reacción alérgica (inicio reciente de vinorelbina y fenitoína). » La analítica muestra leucocitosis moderada con desviación izquierda (15.000 leucocitos, 76% PMN), con PCR elevada (25, rango 0-5 mg/L) y procalcitonina normal. » Radiografía de tórax con mínimo pinzamiento del seno costofrénico derecho. No se objetiva ningún aislamiento microbiológico. » A las 48 horas se realizan TC de reevaluación tóraco-abdominal y cerebral que no muestran lesiones nuevas, con estabilidad de las ya conocidas. Diagnóstico Ante el empeoramiento rápidamente progresivo de las lesiones e inicio de despegamiento cutáneo (Nikolsky +), se solicita valoración por Dermatología, que establece el diagnóstico de síndrome de Stevens-Johnson (SSJ); en base al antecedente de radioterapia holocraneal reciente y toma concomitante de fenitoína, alta sospecha de síndrome EMPACT. Tratamiento Se suspende la fenitoína como probable agente causal y se inician medidas de soporte: movilizaciones controladas, hidratación endovenosa, analgesia y antisépticos tópicos. Evolución Tras la retirada de la fenitoína, la paciente evoluciona de forma lenta, pero favorable y tras 19 días de ingreso recibe el alta a domicilio sin secuelas cutáneas ni mucosas.

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[ "MORFOLOGIA_NEOPLASIA" ]

combination of bezafibrate and guar is a Intervention_Pharmacological, effect is a Outcome_Physical, a dietary fibre is a Intervention_Pharmacological, 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . is a Participant_Condition, Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross - over study for 3 months is a Intervention_Pharmacological, Guar is a Intervention_Pharmacological, total cholesterol is a Outcome_Physical, low density lipoprotein cholesterol ( LDL - cholesterol is a Outcome_Physical, apoprotein B is a Outcome_Physical, plasma triglyceride level and the triglyceride distribution is a Outcome_Physical, fasting plasma glucose level nor the body weight is a Outcome_Physical, guar treatment is a Intervention_Pharmacological, slight nausea , meteorism and constipation is a Outcome_Adverse-effects, bezafibrate . is a Intervention_Pharmacological

80499_task0

Sentence: Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition, Outcome_Adverse-effects

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Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate .

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[ "Intervention_Pharmacological", "Participant_Condition", "Outcome_Physical", "Outcome_Adverse-effects" ]

combination of bezafibrate and guar is a Intervention_Pharmacological, effect is a Outcome_Physical, a dietary fibre is a Intervention_Pharmacological, 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . is a Participant_Condition, Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross - over study for 3 months is a Intervention_Pharmacological, Guar is a Intervention_Pharmacological, total cholesterol is a Outcome_Physical, low density lipoprotein cholesterol ( LDL - cholesterol is a Outcome_Physical, apoprotein B is a Outcome_Physical, plasma triglyceride level and the triglyceride distribution is a Outcome_Physical, fasting plasma glucose level nor the body weight is a Outcome_Physical, guar treatment is a Intervention_Pharmacological, slight nausea , meteorism and constipation is a Outcome_Adverse-effects, bezafibrate . is a Intervention_Pharmacological

80499_task1

Sentence: Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate . Instructions: please typing these entity words according to sentence: combination of bezafibrate and guar, effect, a dietary fibre, 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) ., Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross - over study for 3 months, Guar, total cholesterol, low density lipoprotein cholesterol ( LDL - cholesterol, apoprotein B, plasma triglyceride level and the triglyceride distribution, fasting plasma glucose level nor the body weight, guar treatment, slight nausea , meteorism and constipation, bezafibrate . Options: Intervention_Pharmacological, Outcome_Physical, Participant_Condition, Outcome_Adverse-effects

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Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate .

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[ "Intervention_Pharmacological", "Participant_Condition", "Outcome_Physical", "Outcome_Adverse-effects" ]

combination of bezafibrate and guar, effect, a dietary fibre, 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) ., Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross - over study for 3 months, Guar, total cholesterol, low density lipoprotein cholesterol ( LDL - cholesterol, apoprotein B, plasma triglyceride level and the triglyceride distribution, fasting plasma glucose level nor the body weight, guar treatment, slight nausea , meteorism and constipation, bezafibrate .

80499_task2

Sentence: Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate . Instructions: please extract entity words from the input sentence

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Treatment of familial hypercholesterolemia with a combination of bezafibrate and guar . The effect of guar ( 15.6 g/day ) , a dietary fibre , and simultaneous administration of bezafibrate ( 600 mg/day ) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia ( corresponding to the HLP type IIa pattern ) . Either bezafibrate alone or bezafibrate in combination with guar was administered in a cross-over study for 3 months . Guar led to an additional lowering of the total cholesterol in the plasma by 7 % ( P less than or equal to 0.05 ) associated with a fall of the low density lipoprotein cholesterol ( LDL-cholesterol ( LDL-cholesterol ) by 13 % ( P less than or equal to 0.01 ) without any changes in the very low density lipoprotein ( VLDL ) and high density lipoprotein ( HDL ) cholesterols . In parallel with the decrease in LDL-cholesterol , the apoprotein B also was diminished by 20 % ( P less than or equal to 0.05 ) . The plasma triglyceride level and the triglyceride distribution within the individual lipoprotein fractions were not altered in any consistent manner by the addition of guar . Neither the fasting plasma glucose level nor the body weight were affected . The side-effects due to guar treatment consisted of slight nausea , meteorism and constipation , but this did not in any of the cases lead to early termination of the study . These results demonstrate that guar exerts its cholesterol-lowering effect in addition to that of bezafibrate .

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[ "Intervention_Pharmacological", "Participant_Condition", "Outcome_Physical", "Outcome_Adverse-effects" ]

nativradiologisch is an umlsterm, Unfallmechanismus is an umlsterm, Therapie is an umlsterm, Dislokationen is an umlsterm, Klassifikation is an umlsterm, Frakturen is an umlsterm, Korrekturosteotomie is an umlsterm, Klassifikation is an umlsterm

DerUnfallchirurg.01030791.ger.abstr_task0

Sentence: Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen .

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[ "umlsterm" ]

nativradiologisch is an umlsterm, Unfallmechanismus is an umlsterm, Therapie is an umlsterm, Dislokationen is an umlsterm, Klassifikation is an umlsterm, Frakturen is an umlsterm, Korrekturosteotomie is an umlsterm, Klassifikation is an umlsterm

DerUnfallchirurg.01030791.ger.abstr_task1

Sentence: Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen . Instructions: please typing these entity words according to sentence: nativradiologisch, Unfallmechanismus, Therapie, Dislokationen, Klassifikation, Frakturen, Korrekturosteotomie, Klassifikation Options: umlsterm

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Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen .

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[ "umlsterm" ]

nativradiologisch, Unfallmechanismus, Therapie, Dislokationen, Klassifikation, Frakturen, Korrekturosteotomie, Klassifikation

DerUnfallchirurg.01030791.ger.abstr_task2

Sentence: Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen . Instructions: please extract entity words from the input sentence

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Undislozierte Densbasisfrakturen koennen nativradiologisch ohne Beruecksichtigung des zugrundeliegenden Unfallmechanismus eine Stabilitaet vortaeuschen , die bei konservativer Therapie zu sekundaeren Dislokationen fuehren koennen . Dies wird vor allem bei der Klassifikation der Dens Frakturen nach Anderson und D ' Alonzo leicht uebersehen . Anhand einer Kasuistik wird diese Problematik aufgezeigt , der operative Anspruch einer vermeidbaren , risikoreichen transoralen Korrekturosteotomie dargelegt und auf eine aussagekraeftigere Klassifikation der Densfrakturen verwiesen .

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[ "umlsterm" ]

bone fracture is an umlsterm, patients is an umlsterm, radius is an umlsterm, Germany is an umlsterm, geriatric is an umlsterm, fractures is an umlsterm, hip is an umlsterm, treatment is an umlsterm, older is an umlsterm, patients is an umlsterm, osteoporosis is an umlsterm, fracture is an umlsterm, secondary is an umlsterm, comminuted is an umlsterm, bone is an umlsterm, perception is an umlsterm, tissue is an umlsterm, need is an umlsterm, bone graft is an umlsterm, surgical is an umlsterm, literature review is an umlsterm, radius fractures is an umlsterm, patients is an umlsterm, older is an umlsterm, procedure is an umlsterm, fractures is an umlsterm, radius is an umlsterm, joint is an umlsterm, immobilisation is an umlsterm, complication is an umlsterm, radius fracture is an umlsterm, treatment is an umlsterm, older is an umlsterm, patients is an umlsterm, patients is an umlsterm, risk is an umlsterm, attention is an umlsterm, nerves is an umlsterm, pins is an umlsterm, signs is an umlsterm, complications is an umlsterm, patients is an umlsterm, older is an umlsterm, fracture is an umlsterm, radius is an umlsterm, follow up study is an umlsterm, radius fractures is an umlsterm, classification is an umlsterm, measures is an umlsterm, bone is an umlsterm, bone graft is an umlsterm, times is an umlsterm, disease is an umlsterm, complications is an umlsterm, treatment is an umlsterm, radial nerve is an umlsterm, surgical is an umlsterm, pin is an umlsterm, joints is an umlsterm, patients is an umlsterm, fracture is an umlsterm, patients is an umlsterm, fracture is an umlsterm, treatment is an umlsterm, radius fractures is an umlsterm, older is an umlsterm, patients is an umlsterm

DerOrthopaede.00290318.eng.abstr_task0

Sentence: Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients .

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[ "umlsterm" ]

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DerOrthopaede.00290318.eng.abstr_task1

Sentence: Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients . Instructions: please typing these entity words according to sentence: bone fracture, patients, radius, Germany, geriatric, fractures, hip, treatment, older, patients, osteoporosis, fracture, secondary, comminuted, bone, perception, tissue, need, bone graft, surgical, literature review, radius fractures, patients, older, procedure, fractures, radius, joint, immobilisation, complication, radius fracture, treatment, older, patients, patients, risk, attention, nerves, pins, signs, complications, patients, older, fracture, radius, follow up study, radius fractures, classification, measures, bone, bone graft, times, disease, complications, treatment, radial nerve, surgical, pin, joints, patients, fracture, patients, fracture, treatment, radius fractures, older, patients Options: umlsterm

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Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients .

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[ "umlsterm" ]

bone fracture, patients, radius, Germany, geriatric, fractures, hip, treatment, older, patients, osteoporosis, fracture, secondary, comminuted, bone, perception, tissue, need, bone graft, surgical, literature review, radius fractures, patients, older, procedure, fractures, radius, joint, immobilisation, complication, radius fracture, treatment, older, patients, patients, risk, attention, nerves, pins, signs, complications, patients, older, fracture, radius, follow up study, radius fractures, classification, measures, bone, bone graft, times, disease, complications, treatment, radial nerve, surgical, pin, joints, patients, fracture, patients, fracture, treatment, radius fractures, older, patients

DerOrthopaede.00290318.eng.abstr_task2

Sentence: Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients . Instructions: please extract entity words from the input sentence

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Every 15th case of a bone fracture in patients aged more than 65 years concerns the distal radius in Germany . This means the second rank of all geriatric fractures following fractures of the hip . According to the approved and increased apply of operative stabilisation there are arising more and more reports upon poor results of nonsurgical treatment . Especially in older patients the main reason for the discontented outcome of conservative management is osteoporosis , which is an affirmative circumstance for the genesis of fracture but also for secondary malaligment of comminuted thin cortical walls and crushed porotic cancellous bone . The rational of this perception is either filling artificial bonelike tissue - avoiding the need of harvest cancellous bone graft from a second surgical site - into the resultant cavity following reduction , or supplementary transstyloidal or intrafocal K-wiring until remodeling is obtained within an average of 10 weeks . Both arrangements should be secured in addition with a transarticular external fixation . According to a literature review and our own experiences of 92 follow up cases of distal radius fractures in patients who were older than 65 years this procedure seems to be superior at present for A-2, A-3 and most cases of type-C fractures of the distal radius , despite the disadvantage of joint immobilisation for about 5 weeks . Type B-fractures , however , should be provided better with an internal fixation . Sudeck's algodystrophia is the mostly serious complication of the distal radius fracture and its treatment in older patients . Recognising punctually neurovegetative stimulated patients , treat them cautiously and coming in on their special situation is usually the best way to reduce this risk . To pay attention to the topography of the nerves during the application of the pins and to act at the first signs of complications immediately is also very important . We examined 92 patients who were older than 65 years with a fracture of the distal end of the radius in a follow up study . In this group we treated 62 distal radius fractures of the type A and C of the AO classification with an transarticular external fixateur and with supplementary measures if necessary . Additionally we filled the bone cavity with an artificial bone graft ( Endobon ) following closed reduction in 32 cases , 12 times a complementary K-wiring was added and in 8 cases the external fixateur was combined with both . Sudeck's disease appeared in 1.1 % of all cases . In 5 cases we recorded complications with an obligation to treatment as well . Lesion of the superficial branch of the radial nerve were noted in 2 cases ( 2,1 % ) , as far as we extended the surgical approach for the pin application . Technical problems from the site of the external fixateur appeared in 3 cases , two of them could be attributed to an infirmity of the fixateurs ball joints which is now eliminated by the producer . 4 patients with a type-B fracture was provided by plating , additionally 4 patients with a type-C fracture because of non-compliance . The external fixateur is an essential part of a differentiated treatment with reference to the several types of distal radius fractures in older patients .

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[ "umlsterm" ]

Interleukin-10 is a protein_molecule, interferon alpha- and interferon gamma- induced genes is a (AND DNA_family_or_group DNA_family_or_group), STAT1 is a protein_molecule

51430_task0

Sentence: Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: (AND DNA_family_or_group DNA_family_or_group), protein_molecule

[ "B-protein_molecule", "O", "O", "O", "O", "B-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "O", "O", "O", "O", "O", "B-protein_molecule", "O" ]

Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.

[ "Interleukin-10", "inhibits", "expression", "of", "both", "interferon", "alpha-", "and", "interferon", "gamma-", "induced", "genes", "by", "suppressing", "tyrosine", "phosphorylation", "of", "STAT1", "." ]

[ "protein_family_or_group", "(AND DNA_family_or_group DNA_family_or_group)", "(AND protein_complex protein_complex)", "(AND other_name other_name)", "other_name", "cell_type", "DNA_domain_or_region", "protein_molecule", "", "DNA_family_or_group", "amino_acid_monomer" ]

Interleukin-10 is a protein_molecule, interferon alpha- and interferon gamma- induced genes is a (AND DNA_family_or_group DNA_family_or_group), STAT1 is a protein_molecule

51430_task1

Sentence: Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Instructions: please typing these entity words according to sentence: Interleukin-10, interferon alpha- and interferon gamma- induced genes, STAT1 Options: (AND DNA_family_or_group DNA_family_or_group), protein_molecule

[ "B-protein_molecule", "O", "O", "O", "O", "B-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "O", "O", "O", "O", "O", "B-protein_molecule", "O" ]

Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.

[ "Interleukin-10", "inhibits", "expression", "of", "both", "interferon", "alpha-", "and", "interferon", "gamma-", "induced", "genes", "by", "suppressing", "tyrosine", "phosphorylation", "of", "STAT1", "." ]

[ "protein_family_or_group", "(AND DNA_family_or_group DNA_family_or_group)", "(AND protein_complex protein_complex)", "(AND other_name other_name)", "other_name", "cell_type", "DNA_domain_or_region", "protein_molecule", "", "DNA_family_or_group", "amino_acid_monomer" ]

Interleukin-10, interferon alpha- and interferon gamma- induced genes, STAT1

51430_task2

Sentence: Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Instructions: please extract entity words from the input sentence

[ "B-protein_molecule", "O", "O", "O", "O", "B-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "I-(AND DNA_family_or_group DNA_family_or_group)", "O", "O", "O", "O", "O", "B-protein_molecule", "O" ]

Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.

[ "Interleukin-10", "inhibits", "expression", "of", "both", "interferon", "alpha-", "and", "interferon", "gamma-", "induced", "genes", "by", "suppressing", "tyrosine", "phosphorylation", "of", "STAT1", "." ]

[ "protein_family_or_group", "(AND DNA_family_or_group DNA_family_or_group)", "(AND protein_complex protein_complex)", "(AND other_name other_name)", "other_name", "cell_type", "DNA_domain_or_region", "protein_molecule", "", "DNA_family_or_group", "amino_acid_monomer" ]

Analyse is an umlsterm, Arbeit is an umlsterm, Ausbildung is an umlsterm, Wahrnehmung is an umlsterm, Wissen is an umlsterm, Gegebenen is an umlsterm, selbst is an umlsterm, Wahnidee is an umlsterm, Wahnstimmung is an umlsterm, Wahnwahrnehmung is an umlsterm

DerNervenarzt.80690390.ger.abstr_task0

Sentence: Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang .

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[ "umlsterm" ]

Analyse is an umlsterm, Arbeit is an umlsterm, Ausbildung is an umlsterm, Wahrnehmung is an umlsterm, Wissen is an umlsterm, Gegebenen is an umlsterm, selbst is an umlsterm, Wahnidee is an umlsterm, Wahnstimmung is an umlsterm, Wahnwahrnehmung is an umlsterm

DerNervenarzt.80690390.ger.abstr_task1

Sentence: Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang . Instructions: please typing these entity words according to sentence: Analyse, Arbeit, Ausbildung, Wahrnehmung, Wissen, Gegebenen, selbst, Wahnidee, Wahnstimmung, Wahnwahrnehmung Options: umlsterm

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Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang .

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[ "umlsterm" ]

Analyse, Arbeit, Ausbildung, Wahrnehmung, Wissen, Gegebenen, selbst, Wahnidee, Wahnstimmung, Wahnwahrnehmung

DerNervenarzt.80690390.ger.abstr_task2

Sentence: Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang . Instructions: please extract entity words from the input sentence

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Ausgehend vom Wahnproblem und begruendet auf einer Analyse rationaler und intuitiver Erkenntnis , unternimmt die vorliegende phaenomenologisch-konzeptuelle Arbeit den Versuch einer Wesensbestimmung des Wahns . Intuitive Erkenntnis als Resultat eines holistischen Erkenntnisvorganges beruht auf der Ausbildung polysensorisch-kinaesthetischer Grund- oder Wesensbilder ( Wesensmatrizes ) , die ihrerseits in uebergreifende Bedeutungssysteme einfliessen und ihrem praereflexiv-praeverbalen Wiedererkennen vermittels subliminaler Wahrnehmung entsprechender Wesensstrukturen . Ein positiver Abgleich evoziert eine Wesensempfindung als ein praeverbales Wissen von etwas als etwas Bestimmten . Gleichzeitig enthaelt die Wesensempfindung als unmittelbare Eigenbezueglichkeit das Empfinden der objektbedingten Bedeutung des Gegebenen fuer das Subjekt selbst sowie das Empfinden eines vom Objekt ausgehenden Kraftvektors . Vor diesem Hintergrund laesst sich Wahn als Ausdruck einer Stoerung im System intuitiv-holistischen Erkennens auffassen , bei der es auf verschiedenen Wegen zur Enthemmung und Aktualisierung von Wesensmatrizes bzw. einzelner umgreifender Bedeutungssysteme kommt . Die hierdurch evozierte Wesensempfindung nennen wir Wahn , deren begriffliche Expressionen Wahnidee . Am Wahn lassen sich alle Eigenschaften einer Wesensempfindung aufweisen , die jedoch ihrer besonderen Intensitaet entsprechend und der damit verbundenen Entmaechtigung der Ratio meist als unvergleichlich erscheinen . Die Herausarbeitung wesentlicher Eigenschaften des Wahns laesst ein Gefuege erkennen , das ein tieferes Verstaendnis dieses Phaenomens erlaubt und gleichermassen seine Identifizierung wie seine Abgrenzung erleichtert . Bisher wenig verbundene Begriffe wie Wahnstimmung , Beziehungsidee , Bedeutungserlebnis , Wahneinfall und Wahnwahrnehmung erscheinen in einem sinnvollen Zusammenhang .

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[ "umlsterm" ]

Deep vein thrombosis is a Diseases & Disorders

12213_task0

Sentence: Deep vein thrombosis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Diseases & Disorders

[ "B-Diseases & Disorders", "I-Diseases & Disorders", "I-Diseases & Disorders", "O" ]

Deep vein thrombosis.

[ "Deep", "vein", "thrombosis", "." ]

[ "Chemicals & Drugs", "", "Diseases & Disorders" ]

Deep vein thrombosis is a Diseases & Disorders

12213_task1

Sentence: Deep vein thrombosis. Instructions: please typing these entity words according to sentence: Deep vein thrombosis Options: Diseases & Disorders

[ "B-Diseases & Disorders", "I-Diseases & Disorders", "I-Diseases & Disorders", "O" ]

Deep vein thrombosis.

[ "Deep", "vein", "thrombosis", "." ]

[ "Chemicals & Drugs", "", "Diseases & Disorders" ]

Deep vein thrombosis

12213_task2

Sentence: Deep vein thrombosis. Instructions: please extract entity words from the input sentence

[ "B-Diseases & Disorders", "I-Diseases & Disorders", "I-Diseases & Disorders", "O" ]

Deep vein thrombosis.

[ "Deep", "vein", "thrombosis", "." ]

[ "Chemicals & Drugs", "", "Diseases & Disorders" ]

Estrogen receptor beta is a GENE-Y, tamoxifen is a CHEMICAL, ERalpha is a GENE-Y

17404078_task0

Sentence: Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL

[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]

Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma.

[ "Estrogen", "receptor", "beta", "expression", "is", "associated", "with", "tamoxifen", "response", "in", "ERalpha", "-", "negative", "breast", "carcinoma", "." ]

[ "GENE-Y", "CHEMICAL" ]

Estrogen receptor beta is a GENE-Y, tamoxifen is a CHEMICAL, ERalpha is a GENE-Y

17404078_task1

Sentence: Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Instructions: please typing these entity words according to sentence: Estrogen receptor beta, tamoxifen, ERalpha Options: GENE-Y, CHEMICAL

[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]

Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma.

[ "Estrogen", "receptor", "beta", "expression", "is", "associated", "with", "tamoxifen", "response", "in", "ERalpha", "-", "negative", "breast", "carcinoma", "." ]

[ "GENE-Y", "CHEMICAL" ]

Estrogen receptor beta, tamoxifen, ERalpha

17404078_task2

Sentence: Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Instructions: please extract entity words from the input sentence

[ "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O" ]

Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma.

[ "Estrogen", "receptor", "beta", "expression", "is", "associated", "with", "tamoxifen", "response", "in", "ERalpha", "-", "negative", "breast", "carcinoma", "." ]

[ "GENE-Y", "CHEMICAL" ]

p50 is a Protein, p50 is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein, RelB is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein, RelB is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein

9032344_task0

Sentence: Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals.

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[ "Protein" ]

p50 is a Protein, p50 is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein, RelB is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein, RelB is a Protein, p50 is a Protein, p65 is a Protein, p50 is a Protein

9032344_task1

Sentence: Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals. Instructions: please typing these entity words according to sentence: p50, p50, p50, p65, p50, RelB, p50, p65, p50, RelB, p50, p65, p50 Options: Protein

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Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals.

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[ "Protein" ]

p50, p50, p50, p65, p50, RelB, p50, p65, p50, RelB, p50, p65, p50

9032344_task2

Sentence: Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals. Instructions: please extract entity words from the input sentence

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Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. Human immunodeficiency virus type 1 (HIV-1) replicates more efficiently in vitro in differentiated macrophages than in freshly isolated monocytes. We investigated whether this may be partly explained by changes in expression of NF-kappaB with monocyte differentiation. We demonstrated that constitutive expression of NF-kappaB in primary human monocytes changed significantly with differentiation in vitro to monocyte-derived macrophages (MDMs) and differentiation in vivo to alveolar macrophages (AMs). Freshly isolated monocytes constitutively expressed high levels of transcriptionally inactive p50 homodimer which decreased with time in culture in favor of the transcriptionally active p50/p65 and p50/RelB heterodimers. As in MDMs, AMs constitutively expressed p50/p65 and p50/RelB although at lower levels. HIV infection of fresh monocytes failed to induce p50/p65 as seen in MDMs. The replacement of p50 homodimers with transcriptionally active heterodimers following time in culture may partially explain the progressive increase in susceptibility of monocytes to HIV infection during in vitro culture. The change in NF-kappaB components with monocyte differentiation in vivo may also explain the different transcriptional activities of these cell populations in HIV-infected individuals.

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[ "Protein" ]

Geraet is an umlsterm, Kieferspalten is an umlsterm, Lippen- is an umlsterm, Kieferspaltverschluss is an umlsterm, Analyse is an umlsterm, Wachstums is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Kieferspaltverschluss is an umlsterm, Kieferorthopaede is an umlsterm, Patienten is an umlsterm, Wachstumsstoerung is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, offenen Biss is an umlsterm, Therapie is an umlsterm, Oberkieferlaenge is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Kreuzbisse is an umlsterm, Gebrauch is an umlsterm, Wachstumsstoerung is an umlsterm, Therapie is an umlsterm

MundKieferGesichtschirurgie.80020055.ger.abstr_task0

Sentence: Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden .

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[ "umlsterm" ]

Geraet is an umlsterm, Kieferspalten is an umlsterm, Lippen- is an umlsterm, Kieferspaltverschluss is an umlsterm, Analyse is an umlsterm, Wachstums is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Kieferspaltverschluss is an umlsterm, Kieferorthopaede is an umlsterm, Patienten is an umlsterm, Wachstumsstoerung is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, offenen Biss is an umlsterm, Therapie is an umlsterm, Oberkieferlaenge is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Kreuzbisse is an umlsterm, Gebrauch is an umlsterm, Wachstumsstoerung is an umlsterm, Therapie is an umlsterm

MundKieferGesichtschirurgie.80020055.ger.abstr_task1

Sentence: Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden . Instructions: please typing these entity words according to sentence: Geraet, Kieferspalten, Lippen-, Kieferspaltverschluss, Analyse, Wachstums, Patienten, Patienten, Patienten, Behandlung, Kieferspaltverschluss, Kieferorthopaede, Patienten, Wachstumsstoerung, Patienten, Patienten, offenen Biss, Therapie, Oberkieferlaenge, Patienten, Patienten, Kreuzbisse, Gebrauch, Wachstumsstoerung, Therapie Options: umlsterm

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Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden .

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[ "umlsterm" ]

Geraet, Kieferspalten, Lippen-, Kieferspaltverschluss, Analyse, Wachstums, Patienten, Patienten, Patienten, Behandlung, Kieferspaltverschluss, Kieferorthopaede, Patienten, Wachstumsstoerung, Patienten, Patienten, offenen Biss, Therapie, Oberkieferlaenge, Patienten, Patienten, Kreuzbisse, Gebrauch, Wachstumsstoerung, Therapie

MundKieferGesichtschirurgie.80020055.ger.abstr_task2

Sentence: Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden . Instructions: please extract entity words from the input sentence

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Das von Latham entwickelte Geraet wird im Rahmen der aktiven praechirurgischen Vorbehandlung zur Verschmaelerung von Kieferspalten eingesetzt . Es soll den simultanen Lippen- und Kieferspaltverschluss im Alter von 6 Monaten ( Gingivoperiostplastik nach Millard ) ermoeglichen . Das Ziel dieser Untersuchung besteht in der Analyse des kraniofazialen Wachstums bei Patienten mit LKG-Spalten nach Einsatz des Latham-Geraets . Es wurden longitudinale Serien von lateralen Fernroentgenbildern sowie longitudinale Modellserien von insgesamt 146 Patienten untersucht . 91 dieser Patienten bildeten die Kontrollgruppe ohne Behandlung mit dem Latham-Geraet und ohne mukoperiostalen Kieferspaltverschluss . Ein und derselbe Chirurg und nur ein einziger Kieferorthopaede behandelten alle Patienten nach demselben Schema . Der Untersuchungszeitraum erstreckte sich ueber 16 Jahre . Eine dreidimensionale Wachstumsstoerung wurde nach Einsatz des Latham-Geraets sowie nachfolgender Gingivoperiostplastik beobachtet . 42% der Patienten mit einseitigen und 40% der Patienten mit doppelseitigen LKG-Spalten hatten einen frontal offenen Biss nach dieser Therapie . In der Kontrollgruppe waren es 5 bzw. 10% . Weiterhin war die Oberkieferlaenge bei den Patienten , die mit einem Latham-Geraet und einer Gingivoperiostplastik behandelt wurden , zu gering und es traten bei diesen Patienten haeufiger frontale Kreuzbisse als in der Kontrollgruppe auf . Diese Ergebnisse belegen , dass der Gebrauch des Latham-Geraets und die anschliessende Gingivoperiostplastik zu einer fazialen Wachstumsstoerung fuehren . Deshalb sollte auf den Einsatz des Latham-Geraets in der Therapie ein- und doppelseitiger LKG-Spalten verzichtet werden .

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[ "umlsterm" ]

macular is a Tissue

PMC-2908855-caption-01_task0

Sentence: The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Tissue

[ "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait.

[ "The", "pedigree", "of", "a", "Korean", "family", "with", "macular", "dystrophy", "demonstrating", "the", "characteristics", "of", "an", "autosomal", "dominant", "inheritance", "trait", ".", "\n" ]

[ "Tissue" ]

macular is a Tissue

PMC-2908855-caption-01_task1

Sentence: The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait. Instructions: please typing these entity words according to sentence: macular Options: Tissue

[ "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait.

[ "The", "pedigree", "of", "a", "Korean", "family", "with", "macular", "dystrophy", "demonstrating", "the", "characteristics", "of", "an", "autosomal", "dominant", "inheritance", "trait", ".", "\n" ]

[ "Tissue" ]

macular

PMC-2908855-caption-01_task2

Sentence: The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The pedigree of a Korean family with macular dystrophy demonstrating the characteristics of an autosomal dominant inheritance trait.

[ "The", "pedigree", "of", "a", "Korean", "family", "with", "macular", "dystrophy", "demonstrating", "the", "characteristics", "of", "an", "autosomal", "dominant", "inheritance", "trait", ".", "\n" ]

[ "Tissue" ]

IL-12 is a protein_molecule, IL-2 is a protein_molecule, p38 mitogen - activated protein kinase is a protein_molecule, STAT serine phosphorylation is an other_name

46862_task0

Sentence: The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: other_name, protein_molecule

[ "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]

The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.

[ "The", "functional", "synergy", "between", "IL-12", "and", "IL-2", "involves", "p38", "mitogen", "-", "activated", "protein", "kinase", "and", "is", "associated", "with", "the", "augmentation", "of", "STAT", "serine", "phosphorylation", "." ]

[ "protein_molecule", "protein_family_or_group", "other_name", "(OR cell_type cell_type)", "cell_type", "", "amino_acid_monomer" ]

IL-12 is a protein_molecule, IL-2 is a protein_molecule, p38 mitogen - activated protein kinase is a protein_molecule, STAT serine phosphorylation is an other_name

46862_task1

Sentence: The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation. Instructions: please typing these entity words according to sentence: IL-12, IL-2, p38 mitogen - activated protein kinase, STAT serine phosphorylation Options: other_name, protein_molecule

[ "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]

The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.

[ "The", "functional", "synergy", "between", "IL-12", "and", "IL-2", "involves", "p38", "mitogen", "-", "activated", "protein", "kinase", "and", "is", "associated", "with", "the", "augmentation", "of", "STAT", "serine", "phosphorylation", "." ]

[ "protein_molecule", "protein_family_or_group", "other_name", "(OR cell_type cell_type)", "cell_type", "", "amino_acid_monomer" ]

IL-12, IL-2, p38 mitogen - activated protein kinase, STAT serine phosphorylation

46862_task2

Sentence: The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O" ]

The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.

[ "The", "functional", "synergy", "between", "IL-12", "and", "IL-2", "involves", "p38", "mitogen", "-", "activated", "protein", "kinase", "and", "is", "associated", "with", "the", "augmentation", "of", "STAT", "serine", "phosphorylation", "." ]

[ "protein_molecule", "protein_family_or_group", "other_name", "(OR cell_type cell_type)", "cell_type", "", "amino_acid_monomer" ]

HIV - Infektion is an umlsterm

DerOpthalmologe.90960437.ger.abstr_task0

Sentence: Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind .

[ "Hintergrund", ":", "Die", "fruehesten", "Netzhautveraenderungen", "bei", "einer", "HIV", "-", "Infektion", "sind", "eine", "Mikroangiopathie", "mit", "Cotton", "-", "wool", "-", "Herden", "und", "Mikroaneurysmen", ".", "Mit", "der", "vorliegenden", "Studie", "soll", "geprueft", "werden", ",", "ob", "retinale", "Funktionsstoerungen", "vor", "morphologischen", "Veraenderungen", "mit", "nicht", "invasiven", "Mitteln", "nachweisbar", "und", "eventuell", "als", "prognostische", "Kriterien", "hilfreich", "sind", "." ]

[ "umlsterm" ]

HIV - Infektion is an umlsterm

DerOpthalmologe.90960437.ger.abstr_task1

Sentence: Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind . Instructions: please typing these entity words according to sentence: HIV - Infektion Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind .

[ "Hintergrund", ":", "Die", "fruehesten", "Netzhautveraenderungen", "bei", "einer", "HIV", "-", "Infektion", "sind", "eine", "Mikroangiopathie", "mit", "Cotton", "-", "wool", "-", "Herden", "und", "Mikroaneurysmen", ".", "Mit", "der", "vorliegenden", "Studie", "soll", "geprueft", "werden", ",", "ob", "retinale", "Funktionsstoerungen", "vor", "morphologischen", "Veraenderungen", "mit", "nicht", "invasiven", "Mitteln", "nachweisbar", "und", "eventuell", "als", "prognostische", "Kriterien", "hilfreich", "sind", "." ]

[ "umlsterm" ]

HIV - Infektion

DerOpthalmologe.90960437.ger.abstr_task2

Sentence: Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Hintergrund : Die fruehesten Netzhautveraenderungen bei einer HIV-Infektion sind eine Mikroangiopathie mit Cotton-wool-Herden und Mikroaneurysmen . Mit der vorliegenden Studie soll geprueft werden , ob retinale Funktionsstoerungen vor morphologischen Veraenderungen mit nicht invasiven Mitteln nachweisbar und eventuell als prognostische Kriterien hilfreich sind .

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[ "umlsterm" ]

leukocyte is a Cell, nuclear body is a CellComponent, nuclear body is a CellComponent, NB is a CellComponent, cellular organelle is a CellComponent, NB is a CellComponent, antibodies is a Protein, serum is a PhysicalContinuant, cDNA is a DNA, NB is a CellComponent, protein is a Protein, Sp140 is a Protein, amino acid sequence is a AminoAcid, amino - terminal portion is a ProteinDomain, Sp140 is a Protein, Sp100 is a Protein, NB protein is a Protein, carboxyl portion is a ProteinDomain, Sp140 is a Protein, zinc - finger domain is a ZincCoordinatingDomain, bromodomain is a ProteinDomain, proteins is a Protein, gene is a Gene, Sp140 is a Protein, mRNA is a MessengerRNA, human is a Eukaryote, spleen is a Tissue, peripheral blood leukocytes is a Tissue, SP140 is a Protein, mRNA is a MessengerRNA, cell lines is a Cell, HL60 is a Cell, NB4 is a Cell, chemically is a Chemical, SP140 is a Protein, NB is a CellComponent, HL60 is a Cell, NB4 cells is a Cell, Sp140 is a Protein, NB is a CellComponent, gene is a Gene, cells is a Cell, Sp140 is a Protein

136_task0

Sentence: Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: AminoAcid, DNA, ZincCoordinatingDomain, Tissue, PhysicalContinuant, Chemical, CellComponent, MessengerRNA, Gene, Eukaryote, ProteinDomain, Protein, Cell

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Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.

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[ "Tissue", "ProteinDomain", "AminoAcid", "CellComponent", "ZincCoordinatingDomain", "Protein", "Cell", "Chemical", "Eukaryote", "PhysicalContinuant", "DNA", "Gene", "MessengerRNA" ]

leukocyte is a Cell, nuclear body is a CellComponent, nuclear body is a CellComponent, NB is a CellComponent, cellular organelle is a CellComponent, NB is a CellComponent, antibodies is a Protein, serum is a PhysicalContinuant, cDNA is a DNA, NB is a CellComponent, protein is a Protein, Sp140 is a Protein, amino acid sequence is a AminoAcid, amino - terminal portion is a ProteinDomain, Sp140 is a Protein, Sp100 is a Protein, NB protein is a Protein, carboxyl portion is a ProteinDomain, Sp140 is a Protein, zinc - finger domain is a ZincCoordinatingDomain, bromodomain is a ProteinDomain, proteins is a Protein, gene is a Gene, Sp140 is a Protein, mRNA is a MessengerRNA, human is a Eukaryote, spleen is a Tissue, peripheral blood leukocytes is a Tissue, SP140 is a Protein, mRNA is a MessengerRNA, cell lines is a Cell, HL60 is a Cell, NB4 is a Cell, chemically is a Chemical, SP140 is a Protein, NB is a CellComponent, HL60 is a Cell, NB4 cells is a Cell, Sp140 is a Protein, NB is a CellComponent, gene is a Gene, cells is a Cell, Sp140 is a Protein

136_task1

Sentence: Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. Instructions: please typing these entity words according to sentence: leukocyte, nuclear body, nuclear body, NB, cellular organelle, NB, antibodies, serum, cDNA, NB, protein, Sp140, amino acid sequence, amino - terminal portion, Sp140, Sp100, NB protein, carboxyl portion, Sp140, zinc - finger domain, bromodomain, proteins, gene, Sp140, mRNA, human, spleen, peripheral blood leukocytes, SP140, mRNA, cell lines, HL60, NB4, chemically, SP140, NB, HL60, NB4 cells, Sp140, NB, gene, cells, Sp140 Options: AminoAcid, DNA, ZincCoordinatingDomain, Tissue, PhysicalContinuant, Chemical, CellComponent, MessengerRNA, Gene, Eukaryote, ProteinDomain, Protein, Cell

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Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.

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[ "Tissue", "ProteinDomain", "AminoAcid", "CellComponent", "ZincCoordinatingDomain", "Protein", "Cell", "Chemical", "Eukaryote", "PhysicalContinuant", "DNA", "Gene", "MessengerRNA" ]

leukocyte, nuclear body, nuclear body, NB, cellular organelle, NB, antibodies, serum, cDNA, NB, protein, Sp140, amino acid sequence, amino - terminal portion, Sp140, Sp100, NB protein, carboxyl portion, Sp140, zinc - finger domain, bromodomain, proteins, gene, Sp140, mRNA, human, spleen, peripheral blood leukocytes, SP140, mRNA, cell lines, HL60, NB4, chemically, SP140, NB, HL60, NB4 cells, Sp140, NB, gene, cells, Sp140

136_task2

Sentence: Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. Instructions: please extract entity words from the input sentence

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Identification and characterization of a leukocyte-specific component of the nuclear body. The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection. The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis. In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140. The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein. The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription. High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues. The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation. Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells. The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.

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case report is an umlsterm, old is an umlsterm, child is an umlsterm, methadone is an umlsterm, father is an umlsterm, drug is an umlsterm, time is an umlsterm, methadone is an umlsterm, heroin is an umlsterm, doctors is an umlsterm, signs is an umlsterm, opiate is an umlsterm, intoxication is an umlsterm, coma is an umlsterm, respiratory insufficiency is an umlsterm, diagnosis is an umlsterm, father is an umlsterm, drugs is an umlsterm, father is an umlsterm, drug is an umlsterm, child 's is an umlsterm, history is an umlsterm, methadone is an umlsterm, solution is an umlsterm, baby 's is an umlsterm, child is an umlsterm, methadone is an umlsterm, laboratory is an umlsterm, methadone is an umlsterm, urine is an umlsterm, antidote is an umlsterm, treatment is an umlsterm, naloxone is an umlsterm, body weight is an umlsterm, child is an umlsterm, antidote is an umlsterm

MonatsschriftKinderheilkunde.01480362.eng.abstr_task0

Sentence: This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later .

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[ "umlsterm" ]

case report is an umlsterm, old is an umlsterm, child is an umlsterm, methadone is an umlsterm, father is an umlsterm, drug is an umlsterm, time is an umlsterm, methadone is an umlsterm, heroin is an umlsterm, doctors is an umlsterm, signs is an umlsterm, opiate is an umlsterm, intoxication is an umlsterm, coma is an umlsterm, respiratory insufficiency is an umlsterm, diagnosis is an umlsterm, father is an umlsterm, drugs is an umlsterm, father is an umlsterm, drug is an umlsterm, child 's is an umlsterm, history is an umlsterm, methadone is an umlsterm, solution is an umlsterm, baby 's is an umlsterm, child is an umlsterm, methadone is an umlsterm, laboratory is an umlsterm, methadone is an umlsterm, urine is an umlsterm, antidote is an umlsterm, treatment is an umlsterm, naloxone is an umlsterm, body weight is an umlsterm, child is an umlsterm, antidote is an umlsterm

MonatsschriftKinderheilkunde.01480362.eng.abstr_task1

Sentence: This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later . Instructions: please typing these entity words according to sentence: case report, old, child, methadone, father, drug, time, methadone, heroin, doctors, signs, opiate, intoxication, coma, respiratory insufficiency, diagnosis, father, drugs, father, drug, child 's, history, methadone, solution, baby 's, child, methadone, laboratory, methadone, urine, antidote, treatment, naloxone, body weight, child, antidote Options: umlsterm

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This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later .

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[ "umlsterm" ]

case report, old, child, methadone, father, drug, time, methadone, heroin, doctors, signs, opiate, intoxication, coma, respiratory insufficiency, diagnosis, father, drugs, father, drug, child 's, history, methadone, solution, baby 's, child, methadone, laboratory, methadone, urine, antidote, treatment, naloxone, body weight, child, antidote

MonatsschriftKinderheilkunde.01480362.eng.abstr_task2

Sentence: This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later . Instructions: please extract entity words from the input sentence

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This case report is on a 15-month old child who became intoxicated by methadone prescribed to his father , a drug addict . He at that time was treated with methadone as a substitute for heroin . This fact was not known to the doctors on duty . In spite of the classical signs of opiate intoxication miosis , coma , and respiratory insufficiency , the presumed diagnosis was rejected because the father denied taking any drugs when being asked . It was not before the father admitted to be a drug addict that the child's history became clear : The sweet and reddish methadone solution had been put into a baby's bottle by the members in his doctor's office . Back home the child took it as " his " bottle and swallowed some recalculated 30 mg of methadone . As soon as laboratory examination showed 1.2 mg/l methadone in the urine and 0.1 mg/l in the serum , repeated antidote treatment with 0.01 mg naloxone per kg body weight was started . After 2 days the child was able to breath sufficiently without taking the antidote and was discharged healthy 1 day later .

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[ "umlsterm" ]

Unterkieferfrakturen is an umlsterm, Unterkieferfrakturen is an umlsterm, Frakturen is an umlsterm, Mandibula is an umlsterm, Therapiekonzepten is an umlsterm, Erhebung is an umlsterm, Charakter is an umlsterm, Unterkieferfraktur is an umlsterm, Klassifikation is an umlsterm, Fraktur is an umlsterm, Inzidenz is an umlsterm, Komplikationen is an umlsterm

MundKieferGesichtschirurgie.0004s103.ger.abstr_task0

Sentence: In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden .

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[ "umlsterm" ]

Unterkieferfrakturen is an umlsterm, Unterkieferfrakturen is an umlsterm, Frakturen is an umlsterm, Mandibula is an umlsterm, Therapiekonzepten is an umlsterm, Erhebung is an umlsterm, Charakter is an umlsterm, Unterkieferfraktur is an umlsterm, Klassifikation is an umlsterm, Fraktur is an umlsterm, Inzidenz is an umlsterm, Komplikationen is an umlsterm

MundKieferGesichtschirurgie.0004s103.ger.abstr_task1

Sentence: In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden . Instructions: please typing these entity words according to sentence: Unterkieferfrakturen, Unterkieferfrakturen, Frakturen, Mandibula, Therapiekonzepten, Erhebung, Charakter, Unterkieferfraktur, Klassifikation, Fraktur, Inzidenz, Komplikationen Options: umlsterm

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In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden .

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[ "umlsterm" ]

Unterkieferfrakturen, Unterkieferfrakturen, Frakturen, Mandibula, Therapiekonzepten, Erhebung, Charakter, Unterkieferfraktur, Klassifikation, Fraktur, Inzidenz, Komplikationen

MundKieferGesichtschirurgie.0004s103.ger.abstr_task2

Sentence: In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden . Instructions: please extract entity words from the input sentence

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In der Versorgung von Unterkieferfrakturen konkurrieren bis heute die monokortikale und die funktionsstabile Kompressionsosteosynthese miteinander . Eine Uebersicht ueber die bestehende Litera-tur zeigt , dass komplizierte und schwer reponierbare Unterkieferfrakturen nach einer Kompressionsosteosynthese eine deutlich geringere Komplikationsrate aufweisen , waehrend einfache und nur gering dislozierte Frakturen im distalen Anteil der Mandibula auch mittels monokortikaler Miniplattenosteosynthese erfolgreich versorgt werden koennen . Wegweisend fuer eine geeignete Differenzialindikation zwischen beiden Therapiekonzepten scheint die Erhebung prae- und intraoperativer Parameter , die den Charakter einer Unterkieferfraktur beschreiben und additiv einen Rangwert zur Klassifikation eines Traumas bilden , zu sein . Doch bei nur 7 Einzelparametern - wie im mandibular fracture score - ergeben sich bereits so zahlreiche Kombinationen zur Beschreibung eines Unterkiefertraumas , dass saemtliche bisher angelegten Studien mit ihren geringen Fallzahlen allenfalls eine grobe Differenzialindikation ermoeglichen koennen . Solange keine prospektive Multizenterstudie vorliegt , die eine Entscheidungshilfe in der Wahl des Osteosyntheseverfahrens geben koennte , sollte im fliessenden Bereich zwischen einfacher " und " schwieriger " Fraktur " der funktionsstabilen Kompressionsosteosynthese mit ihrer deutlich geringeren Inzidenz postoperativer Komplikationen der Vorzug gegeben werden .

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[ "umlsterm" ]

gastric metaplasia is a Outcome_Physical, patients with Helicobacter pylori positive duodenal bulb ulcer is a Participant_Condition, patients Helicobacter pylori - positive patients with duodenal bulb ulcer ( DBU ) is a Participant_Condition, One hundred and twenty four is a Participant_Sample-size, patients with DBU is a Participant_Condition, ( gastric metaplasia in the duodenum ) is a Outcome_Physical, Gastric metaplasia in the duodenum is a Outcome_Physical, sensitivity is a Outcome_Other, specificity is a Outcome_Other, predictive accuracy is a Outcome_Other, HP - positive patients is a Participant_Condition

35219_task0

Sentence: [ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Outcome_Physical, Participant_Condition, Participant_Sample-size

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[ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period .

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[ "Participant_Condition", "Outcome_Physical", "Participant_Sample-size", "Outcome_Other" ]

gastric metaplasia is a Outcome_Physical, patients with Helicobacter pylori positive duodenal bulb ulcer is a Participant_Condition, patients Helicobacter pylori - positive patients with duodenal bulb ulcer ( DBU ) is a Participant_Condition, One hundred and twenty four is a Participant_Sample-size, patients with DBU is a Participant_Condition, ( gastric metaplasia in the duodenum ) is a Outcome_Physical, Gastric metaplasia in the duodenum is a Outcome_Physical, sensitivity is a Outcome_Other, specificity is a Outcome_Other, predictive accuracy is a Outcome_Other, HP - positive patients is a Participant_Condition

35219_task1

Sentence: [ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period . Instructions: please typing these entity words according to sentence: gastric metaplasia, patients with Helicobacter pylori positive duodenal bulb ulcer, patients Helicobacter pylori - positive patients with duodenal bulb ulcer ( DBU ), One hundred and twenty four, patients with DBU, ( gastric metaplasia in the duodenum ), Gastric metaplasia in the duodenum, sensitivity, specificity, predictive accuracy, HP - positive patients Options: Outcome_Other, Outcome_Physical, Participant_Condition, Participant_Sample-size

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[ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period .

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[ "Participant_Condition", "Outcome_Physical", "Participant_Sample-size", "Outcome_Other" ]

gastric metaplasia, patients with Helicobacter pylori positive duodenal bulb ulcer, patients Helicobacter pylori - positive patients with duodenal bulb ulcer ( DBU ), One hundred and twenty four, patients with DBU, ( gastric metaplasia in the duodenum ), Gastric metaplasia in the duodenum, sensitivity, specificity, predictive accuracy, HP - positive patients

35219_task2

Sentence: [ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period . Instructions: please extract entity words from the input sentence

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[ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period .

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[ "Participant_Condition", "Outcome_Physical", "Participant_Sample-size", "Outcome_Other" ]

Flavopiridol is a CHEMICAL, flavopiridol is a CHEMICAL, flavonoid is a CHEMICAL, Flavopiridol is a CHEMICAL, cyclin - dependent kinase is a GENE-N, CDK2 is a GENE-Y, flavopiridol is a CHEMICAL, flavopiridol is a CHEMICAL, glucoronide is a CHEMICAL, uridine diphosphate is a CHEMICAL, Flavopiridol is a CHEMICAL, CDK is a GENE-N, flavopiridol is a CHEMICAL

14062_task0

Sentence: Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651]. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL

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Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651].

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

Flavopiridol is a CHEMICAL, flavopiridol is a CHEMICAL, flavonoid is a CHEMICAL, Flavopiridol is a CHEMICAL, cyclin - dependent kinase is a GENE-N, CDK2 is a GENE-Y, flavopiridol is a CHEMICAL, flavopiridol is a CHEMICAL, glucoronide is a CHEMICAL, uridine diphosphate is a CHEMICAL, Flavopiridol is a CHEMICAL, CDK is a GENE-N, flavopiridol is a CHEMICAL

14062_task1

Sentence: Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651]. Instructions: please typing these entity words according to sentence: Flavopiridol, flavopiridol, flavonoid, Flavopiridol, cyclin - dependent kinase, CDK2, flavopiridol, flavopiridol, glucoronide, uridine diphosphate, Flavopiridol, CDK, flavopiridol Options: GENE-Y, GENE-N, CHEMICAL

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Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651].

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

Flavopiridol, flavopiridol, flavonoid, Flavopiridol, cyclin - dependent kinase, CDK2, flavopiridol, flavopiridol, glucoronide, uridine diphosphate, Flavopiridol, CDK, flavopiridol

14062_task2

Sentence: Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651]. Instructions: please extract entity words from the input sentence

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Flavopiridol Hoechst AG. Hoechst is developing flavopiridol, a synthetic flavonoid based on an extract from an Indian plant, for the potential treatment of cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, arrests cell division and causes apoptosis in non-small lung cancer cells [283660]. A phase II trial, in collaboration with the National Cancer Institute, has commenced at the University of Chicago Medical Center, which involves patients with high or intermediate-grade lymphoma or multiple myeloma [272937], [277372]. In ex vivo experiments with tumor cells from refractory chronic lymphoblastic leukemia, dose-dependent CDK2 inhibition associated with apoptotic changes was seen at concentrations greater than 100 nM of flavopiridol. In vitro pharmacokinetic studies have shown that flavopiridol undergoes hepatic biotransformation to its corresponding glucoronide by uridine diphosphate glucoronosyltransferases [283791]. Flavopiridol inhibits CDK with an IC50 value of 0.4 mM [285707]. Preclinical toxicology studies in rats and dogs demonstrated dose-related leukopenia and drug-related lesions in the thymus, spleen and bone marrow. The gastrointestinal and bone marrow toxicity was dose-limiting [178579]. Hoechst Marion Roussel expects to launch flavopiridol in the year 2001, with potential sales in excess of DM 750 million [288651].

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

proband 's is a cohort-patient, his is a gender, case is a cohort-patient, proband is a cohort-patient, his is a gender, proband 's is a cohort-patient, tumor is a disease, his is a gender, proband 's is a cohort-patient, tumor is a disease, his is a gender, dysfunction of the mismatch repair system is a Disorder, tumor is a disease, high frequency MSI is a Disorder, MSI - H is a Disorder, hMSH2 is a gene, hMLH1 is a gene, a c.1864C > A transversion in exon 12 is a mutation, hMSH2 is a gene, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution is a mutation, HNPCC is a disease, hMSH2 is a gene, hMSH2 is a gene, proband 's mother is a cohort-patient, Pro640Leu is a mutation, Pro622Leu is a mutation, hMSH2 is a gene, hMSH2 is a gene

29_task0

Sentence: ** IGNORE LINE ** ** IGNORE LINE ** ** IGNORE LINE ** Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: disease, cohort-patient, gender, Disorder, mutation, gene

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** IGNORE LINE ** ** IGNORE LINE ** ** IGNORE LINE ** Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot

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[ "mutation", "Disorder", "cohort-patient", "gender", "gene", "disease" ]

proband 's is a cohort-patient, his is a gender, case is a cohort-patient, proband is a cohort-patient, his is a gender, proband 's is a cohort-patient, tumor is a disease, his is a gender, proband 's is a cohort-patient, tumor is a disease, his is a gender, dysfunction of the mismatch repair system is a Disorder, tumor is a disease, high frequency MSI is a Disorder, MSI - H is a Disorder, hMSH2 is a gene, hMLH1 is a gene, a c.1864C > A transversion in exon 12 is a mutation, hMSH2 is a gene, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution is a mutation, HNPCC is a disease, hMSH2 is a gene, hMSH2 is a gene, proband 's mother is a cohort-patient, Pro640Leu is a mutation, Pro622Leu is a mutation, hMSH2 is a gene, hMSH2 is a gene

29_task1

Sentence: ** IGNORE LINE ** ** IGNORE LINE ** ** IGNORE LINE ** Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot Instructions: please typing these entity words according to sentence: proband 's, his, case, proband, his, proband 's, tumor, his, proband 's, tumor, his, dysfunction of the mismatch repair system, tumor, high frequency MSI, MSI - H, hMSH2, hMLH1, a c.1864C > A transversion in exon 12, hMSH2, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution, HNPCC, hMSH2, hMSH2, proband 's mother, Pro640Leu, Pro622Leu, hMSH2, hMSH2 Options: disease, cohort-patient, gender, Disorder, mutation, gene

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** IGNORE LINE ** ** IGNORE LINE ** ** IGNORE LINE ** Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot

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[ "mutation", "Disorder", "cohort-patient", "gender", "gene", "disease" ]

proband 's, his, case, proband, his, proband 's, tumor, his, proband 's, tumor, his, dysfunction of the mismatch repair system, tumor, high frequency MSI, MSI - H, hMSH2, hMLH1, a c.1864C > A transversion in exon 12, hMSH2, proline 622 to threonine ( p. Pro622Thr ) amino acid substitution, HNPCC, hMSH2, hMSH2, proband 's mother, Pro640Leu, Pro622Leu, hMSH2, hMSH2

29_task2

Sentence: ** IGNORE LINE ** ** IGNORE LINE ** ** IGNORE LINE ** Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot Instructions: please extract entity words from the input sentence

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** IGNORE LINE ** ** IGNORE LINE ** ** IGNORE LINE ** Results and discussion Our work shows that the absence of proband's non-tumor DNA for MSI testing can be overcome by studying the alleles carried by his progenitors avoiding the need for initial sequencing of the obligate carrier. Although BAT-26 has been reported to be sufficient for MSI-H detection even without normal tissue matching [9], careful interpretation is needed if MSI-H detection is based solely on this marker, since polymorphism at the BAT-26 locus has been detected [10]. A more sensitive approach has been reported using a quasimonomorphic mononucleotide markers panel (that includes BAT-25 and BAT-26) without the need to match normal DNA[11]. In the present case, we overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Microsatellites are inherited according to Mendelian rules like any other genetic markers. Each progenitor pass one of its two alleles to its offspring and by definition, the alleles present in the proband's tumor tissue but absent in his progenitors are the result of somatic mutation. Three out of five microsatellite markers (BAT-25, BAT-26 and D5S346) presented alleles in the proband's primary tumor (T') and its metastasis (T") different from those inherited from his parents. This observation suggested a dysfunction of the mismatch repair system and the tumor was classified as high frequency MSI (MSI-H) according to the NCI workshop [12]. Direct sequencing of the hMSH2 and hMLH1 genes was indicated, detecting a novel germline mutation, a c.1864C>A transversion in exon 12 of hMSH2 gene at the heterozygous state (fig. 3) leading to a proline 622 to threonine (p.Pro622Thr) amino acid substitution. This is the second report involving the 622 codon in HNPCC [13]. DNA sequence analysis of hMSH2 exon 12. Genomic DNA was isolated from leucocytes and PCR amplified with the help of hMSH2 exon 12 flanking primers. In the image the result of the sequencing using the PCR forward primer. Panel A: proband's mother (obligate carrier), positive for the mutation. Panel B: negative control for the mutation. Evolutionary conservation, examined by alignment of sequences of homologous proteins for several species (fig. 4), suggests a functional relevance for the amino acid involved. This is also supported by the mutator phenotype described for Pro640Leu mutant yeast [14], homologous to Pro622Leu hMSH2 substitution in humans (fig. 4). Protein sequence alignment for hMSH2 and homologues. Human, Mouse, Rat, Chicken and Saccharomyces cerevisiae (the site of mutation is highlighted) protein sequence alignment. Evolutionary conservation may indicate the functional relevance of the aminoacid involved for the structure or functioning of the protein. *UniProtKB/Swiss-Prot

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[ "mutation", "Disorder", "cohort-patient", "gender", "gene", "disease" ]

dSir2 is a GENE-Y, dSir2 is a GENE-Y

23129806_task0

Sentence: Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y

[ "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]

Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles.

[ "Fat", "body", "dSir2", "regulates", "muscle", "mitochondrial", "physiology", "and", "energy", "homeostasis", "nonautonomously", "and", "mimics", "the", "autonomous", "functions", "of", "dSir2", "in", "muscles", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

dSir2 is a GENE-Y, dSir2 is a GENE-Y

23129806_task1

Sentence: Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles. Instructions: please typing these entity words according to sentence: dSir2, dSir2 Options: GENE-Y

[ "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]

Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles.

[ "Fat", "body", "dSir2", "regulates", "muscle", "mitochondrial", "physiology", "and", "energy", "homeostasis", "nonautonomously", "and", "mimics", "the", "autonomous", "functions", "of", "dSir2", "in", "muscles", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

dSir2, dSir2

23129806_task2

Sentence: Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O", "O" ]

Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles.

[ "Fat", "body", "dSir2", "regulates", "muscle", "mitochondrial", "physiology", "and", "energy", "homeostasis", "nonautonomously", "and", "mimics", "the", "autonomous", "functions", "of", "dSir2", "in", "muscles", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

silencer is a DNA_family_or_group, interleukin-2 gene is a DNA_domain_or_region, memory resting T helper lymphocytes is a cell_type

80784_task0

Sentence: Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_family_or_group, cell_type, DNA_domain_or_region

[ "O", "O", "O", "B-DNA_family_or_group", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O" ]

Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes.

[ "Occurrence", "of", "a", "silencer", "of", "the", "interleukin-2", "gene", "in", "naive", "but", "not", "in", "memory", "resting", "T", "helper", "lymphocytes", "." ]

[ "other_name", "cell_type", "DNA_domain_or_region", "cell_line", "protein_family_or_group", "protein_molecule", "DNA_family_or_group", "cell_component" ]

silencer is a DNA_family_or_group, interleukin-2 gene is a DNA_domain_or_region, memory resting T helper lymphocytes is a cell_type

80784_task1

Sentence: Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes. Instructions: please typing these entity words according to sentence: silencer, interleukin-2 gene, memory resting T helper lymphocytes Options: DNA_family_or_group, cell_type, DNA_domain_or_region

[ "O", "O", "O", "B-DNA_family_or_group", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O" ]

Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes.

[ "Occurrence", "of", "a", "silencer", "of", "the", "interleukin-2", "gene", "in", "naive", "but", "not", "in", "memory", "resting", "T", "helper", "lymphocytes", "." ]

[ "other_name", "cell_type", "DNA_domain_or_region", "cell_line", "protein_family_or_group", "protein_molecule", "DNA_family_or_group", "cell_component" ]

silencer, interleukin-2 gene, memory resting T helper lymphocytes

80784_task2

Sentence: Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-DNA_family_or_group", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "O", "O", "O", "B-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "I-cell_type", "O" ]

Occurrence of a silencer of the interleukin-2 gene in naive but not in memory resting T helper lymphocytes.

[ "Occurrence", "of", "a", "silencer", "of", "the", "interleukin-2", "gene", "in", "naive", "but", "not", "in", "memory", "resting", "T", "helper", "lymphocytes", "." ]

[ "other_name", "cell_type", "DNA_domain_or_region", "cell_line", "protein_family_or_group", "protein_molecule", "DNA_family_or_group", "cell_component" ]

woman is an umlsterm, baby is an umlsterm, caesarean section is an umlsterm, placental abruption is an umlsterm, bradycardia is an umlsterm, dyspnea is an umlsterm, tachycardia is an umlsterm, hypotension is an umlsterm, transaminase is an umlsterm, pulmonary embolism is an umlsterm, CT scan is an umlsterm, hematoma is an umlsterm, liver is an umlsterm, vena cava is an umlsterm, laparotomy is an umlsterm, spontaneous rupture is an umlsterm, liver is an umlsterm, capsule is an umlsterm, hemorrhage is an umlsterm, liver is an umlsterm, hematoma is an umlsterm, postoperative is an umlsterm

DerChirurg.90700214.eng.abstr_task0

Sentence: A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful .

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[ "umlsterm" ]

woman is an umlsterm, baby is an umlsterm, caesarean section is an umlsterm, placental abruption is an umlsterm, bradycardia is an umlsterm, dyspnea is an umlsterm, tachycardia is an umlsterm, hypotension is an umlsterm, transaminase is an umlsterm, pulmonary embolism is an umlsterm, CT scan is an umlsterm, hematoma is an umlsterm, liver is an umlsterm, vena cava is an umlsterm, laparotomy is an umlsterm, spontaneous rupture is an umlsterm, liver is an umlsterm, capsule is an umlsterm, hemorrhage is an umlsterm, liver is an umlsterm, hematoma is an umlsterm, postoperative is an umlsterm

DerChirurg.90700214.eng.abstr_task1

Sentence: A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful . Instructions: please typing these entity words according to sentence: woman, baby, caesarean section, placental abruption, bradycardia, dyspnea, tachycardia, hypotension, transaminase, pulmonary embolism, CT scan, hematoma, liver, vena cava, laparotomy, spontaneous rupture, liver, capsule, hemorrhage, liver, hematoma, postoperative Options: umlsterm

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful .

[ "A", "25-year", "-", "old", "woman", "delivered", "a", "healthy", "baby", "in", "the", "34th", "week", "of", "gestation", "by", "caesarean", "section", "due", "to", "placental", "abruption", "and", "fetal", "bradycardia", ".", "On", "the", "following", "day", "she", "developed", "dyspnea", ",", "tachycardia", ",", "hypotension", "and", "rising", "serum", "transaminase", "levels", ".", "After", "exclusion", "of", "a", "pulmonary", "embolism", ",", "the", "abdominal", "CT", "scan", "and", "cavography", "revealed", "a", "subcapsular", "hematoma", "of", "the", "entire", "dorsal", "liver", "surface", "and", "compression", "of", "the", "retrohepatic", "vena", "cava", ".", "During", "laparotomy", "a", "spontaneous", "rupture", "of", "the", "liver", "capsule", "with", "intraperitoneal", "hemorrhage", "was", "found", ".", "The", "dorsal", "liver", "was", "decapsulated", "and", "the", "subcapsular", "hematoma", "completely", "removed", ".", "The", "postoperative", "course", "was", "uneventful", "." ]

[ "umlsterm" ]

woman, baby, caesarean section, placental abruption, bradycardia, dyspnea, tachycardia, hypotension, transaminase, pulmonary embolism, CT scan, hematoma, liver, vena cava, laparotomy, spontaneous rupture, liver, capsule, hemorrhage, liver, hematoma, postoperative

DerChirurg.90700214.eng.abstr_task2

Sentence: A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

A 25-year-old woman delivered a healthy baby in the 34th week of gestation by caesarean section due to placental abruption and fetal bradycardia . On the following day she developed dyspnea , tachycardia , hypotension and rising serum transaminase levels . After exclusion of a pulmonary embolism , the abdominal CT scan and cavography revealed a subcapsular hematoma of the entire dorsal liver surface and compression of the retrohepatic vena cava . During laparotomy a spontaneous rupture of the liver capsule with intraperitoneal hemorrhage was found . The dorsal liver was decapsulated and the subcapsular hematoma completely removed . The postoperative course was uneventful .

[ "A", "25-year", "-", "old", "woman", "delivered", "a", "healthy", "baby", "in", "the", "34th", "week", "of", "gestation", "by", "caesarean", "section", "due", "to", "placental", "abruption", "and", "fetal", "bradycardia", ".", "On", "the", "following", "day", "she", "developed", "dyspnea", ",", "tachycardia", ",", "hypotension", "and", "rising", "serum", "transaminase", "levels", ".", "After", "exclusion", "of", "a", "pulmonary", "embolism", ",", "the", "abdominal", "CT", "scan", "and", "cavography", "revealed", "a", "subcapsular", "hematoma", "of", "the", "entire", "dorsal", "liver", "surface", "and", "compression", "of", "the", "retrohepatic", "vena", "cava", ".", "During", "laparotomy", "a", "spontaneous", "rupture", "of", "the", "liver", "capsule", "with", "intraperitoneal", "hemorrhage", "was", "found", ".", "The", "dorsal", "liver", "was", "decapsulated", "and", "the", "subcapsular", "hematoma", "completely", "removed", ".", "The", "postoperative", "course", "was", "uneventful", "." ]

[ "umlsterm" ]

dye is an umlsterm, laser is an umlsterm, pulse is an umlsterm, treatment is an umlsterm, leg is an umlsterm, veins is an umlsterm, single is an umlsterm, test is an umlsterm, treatments is an umlsterm, test is an umlsterm, persons is an umlsterm, vessels is an umlsterm, treatments is an umlsterm, vessels is an umlsterm, Treatment is an umlsterm, vessels is an umlsterm, side effects is an umlsterm, hypopigmentation is an umlsterm, sclerotherapy is an umlsterm, laser is an umlsterm, device is an umlsterm, treatment is an umlsterm, leg is an umlsterm, vein is an umlsterm, ectasia is an umlsterm

DerHautarzt.80490560.eng.abstr_task0

Sentence: A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O" ]

A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia .

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[ "umlsterm" ]

dye is an umlsterm, laser is an umlsterm, pulse is an umlsterm, treatment is an umlsterm, leg is an umlsterm, veins is an umlsterm, single is an umlsterm, test is an umlsterm, treatments is an umlsterm, test is an umlsterm, persons is an umlsterm, vessels is an umlsterm, treatments is an umlsterm, vessels is an umlsterm, Treatment is an umlsterm, vessels is an umlsterm, side effects is an umlsterm, hypopigmentation is an umlsterm, sclerotherapy is an umlsterm, laser is an umlsterm, device is an umlsterm, treatment is an umlsterm, leg is an umlsterm, vein is an umlsterm, ectasia is an umlsterm

DerHautarzt.80490560.eng.abstr_task1

Sentence: A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia . Instructions: please typing these entity words according to sentence: dye, laser, pulse, treatment, leg, veins, single, test, treatments, test, persons, vessels, treatments, vessels, Treatment, vessels, side effects, hypopigmentation, sclerotherapy, laser, device, treatment, leg, vein, ectasia Options: umlsterm

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A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia .

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[ "umlsterm" ]

dye, laser, pulse, treatment, leg, veins, single, test, treatments, test, persons, vessels, treatments, vessels, Treatment, vessels, side effects, hypopigmentation, sclerotherapy, laser, device, treatment, leg, vein, ectasia

DerHautarzt.80490560.eng.abstr_task2

Sentence: A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia . Instructions: please extract entity words from the input sentence

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A new flashlamp-pumped pulsed dye laser with 1,5 ms pulse length and tunable wavelengths between 585 and 600 nm ( Candela ScleroPLUS ) is now available for the treatment of ectatic leg veins . We evaluated 232 single test treatments using 595 and 600 nm wavelength in 75 test persons . For smaller vessels up to a diameter of 0,5 mm , treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively ; for vessels up to 1 mm in 27 and 33% . Treatment at 595 nm was a little more effective than at 600 nm . Larger vessels could not be treated effectively . The main side effects consisted in hyper- ( 34% ) or hypopigmentation ( 30% ) . Thus , in addition to the usual sclerotherapy , this laser is a useful device for the treatment of leg vein ectasia .

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[ "umlsterm" ]

insulin is a GENE-Y

23489521_task0

Sentence: The use of insulin analogues in pregnancy. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y

[ "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O" ]

The use of insulin analogues in pregnancy.

[ "The", "use", "of", "insulin", "analogues", "in", "pregnancy", "." ]

[ "GENE-Y", "CHEMICAL" ]

insulin is a GENE-Y

23489521_task1

Sentence: The use of insulin analogues in pregnancy. Instructions: please typing these entity words according to sentence: insulin Options: GENE-Y

[ "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O" ]

The use of insulin analogues in pregnancy.

[ "The", "use", "of", "insulin", "analogues", "in", "pregnancy", "." ]

[ "GENE-Y", "CHEMICAL" ]

insulin

23489521_task2

Sentence: The use of insulin analogues in pregnancy. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-GENE-Y", "O", "O", "O", "O" ]

The use of insulin analogues in pregnancy.

[ "The", "use", "of", "insulin", "analogues", "in", "pregnancy", "." ]

[ "GENE-Y", "CHEMICAL" ]

defects is an umlsterm, pelvic region is an umlsterm, sequelae is an umlsterm, debridement is an umlsterm, tissue is an umlsterm, patient is an umlsterm, plastic surgery is an umlsterm, procedures is an umlsterm, therapeutic is an umlsterm

DerChirurg.70680469.eng.abstr_task0

Sentence: Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept .

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[ "umlsterm" ]

defects is an umlsterm, pelvic region is an umlsterm, sequelae is an umlsterm, debridement is an umlsterm, tissue is an umlsterm, patient is an umlsterm, plastic surgery is an umlsterm, procedures is an umlsterm, therapeutic is an umlsterm

DerChirurg.70680469.eng.abstr_task1

Sentence: Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept . Instructions: please typing these entity words according to sentence: defects, pelvic region, sequelae, debridement, tissue, patient, plastic surgery, procedures, therapeutic Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept .

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[ "umlsterm" ]

defects, pelvic region, sequelae, debridement, tissue, patient, plastic surgery, procedures, therapeutic

DerChirurg.70680469.eng.abstr_task2

Sentence: Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]

Complex defects of the trunk and pelvic region are rare , but are mostly the sequelae of serious conditions . Stable soft tisue coverage after radical debridement of all avital tissue may be of vital importance for the patient . The article will demonstrate the options of plastic surgery procedures that should be known by the general surgeon to be eventually integrated into a interdisciplinary therapeutic concept .

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[ "umlsterm" ]

Angioplasty is an umlsterm, syndromes is an umlsterm, vessel is an umlsterm, stent - like is an umlsterm, angioplasty is an umlsterm, PTCA is an umlsterm, vessel is an umlsterm, syndromes is an umlsterm, prospective study is an umlsterm, patients is an umlsterm, myocardial infarction is an umlsterm, unstable angina is an umlsterm, PTCA is an umlsterm, patients is an umlsterm, angiography is an umlsterm, All is an umlsterm, angiograms is an umlsterm, measurements is an umlsterm, vessel is an umlsterm, patients is an umlsterm, patients is an umlsterm, analysis is an umlsterm, risk factors is an umlsterm, diabetes mellitus is an umlsterm, relative risk is an umlsterm, hypertension is an umlsterm, stenosis is an umlsterm, stents is an umlsterm, multivariate analysis is an umlsterm, hypertension is an umlsterm, risk factors is an umlsterm, Diabetes is an umlsterm, risk factor is an umlsterm, patients is an umlsterm, PTCA is an umlsterm, occurrence is an umlsterm, vessel is an umlsterm, patients is an umlsterm, PTCA is an umlsterm, stents is an umlsterm, stenosis is an umlsterm, procedure is an umlsterm, diabetes is an umlsterm, hypertension is an umlsterm

ZfuerKardiologie.00890485.eng.abstr_task0

Sentence: Angioplasty in acute coronary syndromes is complicated by a high rate of early vessel reocclusion and restenosis . Therefore , it is recommended to achieve a " stent-like " result by percutaneous transluminal coronary angioplasty ( PTCA ) or otherwise use coronary stenting ( provisional stenting ) . This study sought to determine angiographic and patient-related factors that are associated with early target vessel reocclusion or luminal renarrowing after coronary intervention in acute coronary syndromes ( ACS ) . In an observational prospective study we investigated 161 patients with ACS ( acute myocardial infarction and unstable angina ) submitted to PTCA . In 140 patients a follow-up angiography after 10 days was obtained . All angiograms were quantitatively evaluated by computerized measurements . Target vessel reocclusion and early luminal renarrowing was observed in 10 patients ( 7.1% ) and 19 patients ( 13.6% ) , respectively . Using univariate analysis , significant risk factors ( P 0.05 ) for early reocclusion and renarrowing were diabetes mellitus ( relative risk [ RR ] 6.1 and 5.0 ) , arterial hypertension ( RR 7.7 and 3.3 ) , postprocedural lesion length > =2 . 5mm ( RR 6.8 and 7.1 ) , postprocedural minimal lumen diameter =2 . 5 mm ( RR9.0 and 5.8 ) , residual stenosis > =25% ( RR 4.8 and 3.5 ) and absence of stents ( RR 4.1 and 3.2 ) . Moreover , in multivariate analysis hypertension and postprocedural lesion length could be identified as independent risk factors for reocclusion and renarrowing . Diabetes mellitus was found to be an independent risk factor for renarrowing . Conclusions : In a consecutive series of patients with ACS undergoing PTCA with provisional stenting the occurrence of early target vessel reocclusion and luminal renarrowing is lower than previously reported for this subset of patients treated by PTCA alone . Adverse outcome is related to absence of stents , angiographic factors ( residual stenosis , lesion length , minimal lumen diameter after procedure ) and patient-related factors such as diabetes and hypertension . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Angioplasty in acute coronary syndromes is complicated by a high rate of early vessel reocclusion and restenosis . Therefore , it is recommended to achieve a " stent-like " result by percutaneous transluminal coronary angioplasty ( PTCA ) or otherwise use coronary stenting ( provisional stenting ) . This study sought to determine angiographic and patient-related factors that are associated with early target vessel reocclusion or luminal renarrowing after coronary intervention in acute coronary syndromes ( ACS ) . In an observational prospective study we investigated 161 patients with ACS ( acute myocardial infarction and unstable angina ) submitted to PTCA . In 140 patients a follow-up angiography after 10 days was obtained . All angiograms were quantitatively evaluated by computerized measurements . Target vessel reocclusion and early luminal renarrowing was observed in 10 patients ( 7.1% ) and 19 patients ( 13.6% ) , respectively . Using univariate analysis , significant risk factors ( P 0.05 ) for early reocclusion and renarrowing were diabetes mellitus ( relative risk [ RR ] 6.1 and 5.0 ) , arterial hypertension ( RR 7.7 and 3.3 ) , postprocedural lesion length > =2 . 5mm ( RR 6.8 and 7.1 ) , postprocedural minimal lumen diameter =2 . 5 mm ( RR9.0 and 5.8 ) , residual stenosis > =25% ( RR 4.8 and 3.5 ) and absence of stents ( RR 4.1 and 3.2 ) . Moreover , in multivariate analysis hypertension and postprocedural lesion length could be identified as independent risk factors for reocclusion and renarrowing . Diabetes mellitus was found to be an independent risk factor for renarrowing . Conclusions : In a consecutive series of patients with ACS undergoing PTCA with provisional stenting the occurrence of early target vessel reocclusion and luminal renarrowing is lower than previously reported for this subset of patients treated by PTCA alone . Adverse outcome is related to absence of stents , angiographic factors ( residual stenosis , lesion length , minimal lumen diameter after procedure ) and patient-related factors such as diabetes and hypertension .

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[ "umlsterm" ]

Angioplasty is an umlsterm, syndromes is an umlsterm, vessel is an umlsterm, stent - like is an umlsterm, angioplasty is an umlsterm, PTCA is an umlsterm, vessel is an umlsterm, syndromes is an umlsterm, prospective study is an umlsterm, patients is an umlsterm, myocardial infarction is an umlsterm, unstable angina is an umlsterm, PTCA is an umlsterm, patients is an umlsterm, angiography is an umlsterm, All is an umlsterm, angiograms is an umlsterm, measurements is an umlsterm, vessel is an umlsterm, patients is an umlsterm, patients is an umlsterm, analysis is an umlsterm, risk factors is an umlsterm, diabetes mellitus is an umlsterm, relative risk is an umlsterm, hypertension is an umlsterm, stenosis is an umlsterm, stents is an umlsterm, multivariate analysis is an umlsterm, hypertension is an umlsterm, risk factors is an umlsterm, Diabetes is an umlsterm, risk factor is an umlsterm, patients is an umlsterm, PTCA is an umlsterm, occurrence is an umlsterm, vessel is an umlsterm, patients is an umlsterm, PTCA is an umlsterm, stents is an umlsterm, stenosis is an umlsterm, procedure is an umlsterm, diabetes is an umlsterm, hypertension is an umlsterm

ZfuerKardiologie.00890485.eng.abstr_task1

Sentence: Angioplasty in acute coronary syndromes is complicated by a high rate of early vessel reocclusion and restenosis . Therefore , it is recommended to achieve a " stent-like " result by percutaneous transluminal coronary angioplasty ( PTCA ) or otherwise use coronary stenting ( provisional stenting ) . This study sought to determine angiographic and patient-related factors that are associated with early target vessel reocclusion or luminal renarrowing after coronary intervention in acute coronary syndromes ( ACS ) . In an observational prospective study we investigated 161 patients with ACS ( acute myocardial infarction and unstable angina ) submitted to PTCA . In 140 patients a follow-up angiography after 10 days was obtained . All angiograms were quantitatively evaluated by computerized measurements . Target vessel reocclusion and early luminal renarrowing was observed in 10 patients ( 7.1% ) and 19 patients ( 13.6% ) , respectively . Using univariate analysis , significant risk factors ( P 0.05 ) for early reocclusion and renarrowing were diabetes mellitus ( relative risk [ RR ] 6.1 and 5.0 ) , arterial hypertension ( RR 7.7 and 3.3 ) , postprocedural lesion length > =2 . 5mm ( RR 6.8 and 7.1 ) , postprocedural minimal lumen diameter =2 . 5 mm ( RR9.0 and 5.8 ) , residual stenosis > =25% ( RR 4.8 and 3.5 ) and absence of stents ( RR 4.1 and 3.2 ) . Moreover , in multivariate analysis hypertension and postprocedural lesion length could be identified as independent risk factors for reocclusion and renarrowing . Diabetes mellitus was found to be an independent risk factor for renarrowing . Conclusions : In a consecutive series of patients with ACS undergoing PTCA with provisional stenting the occurrence of early target vessel reocclusion and luminal renarrowing is lower than previously reported for this subset of patients treated by PTCA alone . Adverse outcome is related to absence of stents , angiographic factors ( residual stenosis , lesion length , minimal lumen diameter after procedure ) and patient-related factors such as diabetes and hypertension . Instructions: please typing these entity words according to sentence: Angioplasty, syndromes, vessel, stent - like, angioplasty, PTCA, vessel, syndromes, prospective study, patients, myocardial infarction, unstable angina, PTCA, patients, angiography, All, angiograms, measurements, vessel, patients, patients, analysis, risk factors, diabetes mellitus, relative risk, hypertension, stenosis, stents, multivariate analysis, hypertension, risk factors, Diabetes, risk factor, patients, PTCA, occurrence, vessel, patients, PTCA, stents, stenosis, procedure, diabetes, hypertension Options: umlsterm

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Angioplasty in acute coronary syndromes is complicated by a high rate of early vessel reocclusion and restenosis . Therefore , it is recommended to achieve a " stent-like " result by percutaneous transluminal coronary angioplasty ( PTCA ) or otherwise use coronary stenting ( provisional stenting ) . This study sought to determine angiographic and patient-related factors that are associated with early target vessel reocclusion or luminal renarrowing after coronary intervention in acute coronary syndromes ( ACS ) . In an observational prospective study we investigated 161 patients with ACS ( acute myocardial infarction and unstable angina ) submitted to PTCA . In 140 patients a follow-up angiography after 10 days was obtained . All angiograms were quantitatively evaluated by computerized measurements . Target vessel reocclusion and early luminal renarrowing was observed in 10 patients ( 7.1% ) and 19 patients ( 13.6% ) , respectively . Using univariate analysis , significant risk factors ( P 0.05 ) for early reocclusion and renarrowing were diabetes mellitus ( relative risk [ RR ] 6.1 and 5.0 ) , arterial hypertension ( RR 7.7 and 3.3 ) , postprocedural lesion length > =2 . 5mm ( RR 6.8 and 7.1 ) , postprocedural minimal lumen diameter =2 . 5 mm ( RR9.0 and 5.8 ) , residual stenosis > =25% ( RR 4.8 and 3.5 ) and absence of stents ( RR 4.1 and 3.2 ) . Moreover , in multivariate analysis hypertension and postprocedural lesion length could be identified as independent risk factors for reocclusion and renarrowing . Diabetes mellitus was found to be an independent risk factor for renarrowing . Conclusions : In a consecutive series of patients with ACS undergoing PTCA with provisional stenting the occurrence of early target vessel reocclusion and luminal renarrowing is lower than previously reported for this subset of patients treated by PTCA alone . Adverse outcome is related to absence of stents , angiographic factors ( residual stenosis , lesion length , minimal lumen diameter after procedure ) and patient-related factors such as diabetes and hypertension .

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[ "umlsterm" ]