bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

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atopic dermatitis - like skin lesions is a DISEASE, Atopic dermatitis is a DISEASE, AD is a DISEASE, chronic inflammatory skin disease is a DISEASE, skin inflammation is a DISEASE, AD - like skin lesions is a DISEASE, AD - like skin lesions is a DISEASE, ear swelling is a DISEASE, skin inflammation is a DISEASE, AD is a DISEASE, inflammatory skin diseases is a DISEASE	example-207_task1	Sentence: Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice. Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-alpha expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases. Instructions: please typing these entity words according to sentence: atopic dermatitis - like skin lesions, Atopic dermatitis, AD, chronic inflammatory skin disease, skin inflammation, AD - like skin lesions, AD - like skin lesions, ear swelling, skin inflammation, AD, inflammatory skin diseases Options: DISEASE	[ "O", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "B-DISEASE", "O", "O", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "B-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "O" ]	Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice. Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-alpha expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases.	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atopic dermatitis - like skin lesions, Atopic dermatitis, AD, chronic inflammatory skin disease, skin inflammation, AD - like skin lesions, AD - like skin lesions, ear swelling, skin inflammation, AD, inflammatory skin diseases	example-207_task2	Sentence: Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice. Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-alpha expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "B-DISEASE", "O", "O", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "O", "B-DISEASE", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DISEASE", "I-DISEASE", "I-DISEASE", "O" ]	Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice. Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-alpha expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases.	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children is a Participant_Age, autism is a Participant_Condition, social - interaction - based therapy is a Intervention_Psychological, effectiveness is a Outcome_Other, MEHRIT , a social - interaction - based intervention is a Intervention_Educational, communicative language acts is a Outcome_Mental, outperformed is a Outcome_Other, MLUm , number of utterances produced , and various speech act categories . is a Outcome_Mental, functional language measures is a Outcome_Other, children ' s use of language during parent - child interactions is a Outcome_Other	67834_task0	Sentence: Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Psychological, Participant_Condition, Intervention_Educational, Participant_Age, Outcome_Other, Outcome_Mental	[ "O", "O", "O", "O", "O", "O", "B-Participant_Age", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O" ]	Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions .	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children is a Participant_Age, autism is a Participant_Condition, social - interaction - based therapy is a Intervention_Psychological, effectiveness is a Outcome_Other, MEHRIT , a social - interaction - based intervention is a Intervention_Educational, communicative language acts is a Outcome_Mental, outperformed is a Outcome_Other, MLUm , number of utterances produced , and various speech act categories . is a Outcome_Mental, functional language measures is a Outcome_Other, children ' s use of language during parent - child interactions is a Outcome_Other	67834_task1	Sentence: Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions . Instructions: please typing these entity words according to sentence: children, autism, social - interaction - based therapy, effectiveness, MEHRIT , a social - interaction - based intervention, communicative language acts, outperformed, MLUm , number of utterances produced , and various speech act categories ., functional language measures, children ' s use of language during parent - child interactions Options: Intervention_Psychological, Participant_Condition, Intervention_Educational, Participant_Age, Outcome_Other, Outcome_Mental	[ "O", "O", "O", "O", "O", "O", "B-Participant_Age", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O" ]	Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions .	[ "Measuring", "and", "supporting", "language", "function", "for", "children", "with", "autism", ":", "evidence", "from", "a", "randomized", "control", "trial", "of", "a", "social", "-", "interaction", "-", "based", "therapy", ".", "In", "a", "report", "of", "the", "effectiveness", "of", "MEHRIT", ",", "a", "social", "-", "interaction", "-", "based", "intervention", "for", "autism", ",", "Casenhiser", "et", "al", ".", "(", "Autism", "17", "(", "2", ")", ":", "220", "-", "241", ",", "2013", ")", "failed", "to", "find", "a", "significant", "advantage", "for", "language", "development", "in", "the", "treatment", "group", "using", "standardized", "language", "assessments", ".", "We", "present", "the", "results", "from", "a", "re", "-", "analysis", "of", "their", "results", "to", "illustrate", "the", "importance", "of", "measuring", "communicative", "language", "acts", "(", "formally", "called", "\"", "speech", "acts", "\"", ")", ".", "Reanalysis", "confirmed", "that", "children", "in", "the", "MEHRIT", "group", "outperformed", "the", "community", "treatment", "group", "on", "measures", "of", "MLUm", ",", "number", "of", "utterances", "produced", ",", "and", "various", "speech", "act", "categories", ".", "The", "study", "underscores", "the", "importance", "of", "functional", "language", "measures", "in", "guiding", "and", "evaluating", "treatment", "for", "children", "with", "autism", ",", "and", "suggests", "that", "MEHRIT", "is", "effective", "in", "improving", "children", "'", "s", "use", "of", "language", "during", "parent", "-", "child", "interactions", "." ]	[ "Outcome_Mental", "Outcome_Other", "Intervention_Educational", "Intervention_Psychological", "Participant_Age", "Participant_Condition" ]
children, autism, social - interaction - based therapy, effectiveness, MEHRIT , a social - interaction - based intervention, communicative language acts, outperformed, MLUm , number of utterances produced , and various speech act categories ., functional language measures, children ' s use of language during parent - child interactions	67834_task2	Sentence: Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Participant_Age", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O" ]	Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions .	[ "Measuring", "and", "supporting", "language", "function", "for", "children", "with", "autism", ":", "evidence", "from", "a", "randomized", "control", "trial", "of", "a", "social", "-", "interaction", "-", "based", "therapy", ".", "In", "a", "report", "of", "the", "effectiveness", "of", "MEHRIT", ",", "a", "social", "-", "interaction", "-", "based", "intervention", "for", "autism", ",", "Casenhiser", "et", "al", ".", "(", "Autism", "17", "(", "2", ")", ":", "220", "-", "241", ",", "2013", ")", "failed", "to", "find", "a", "significant", "advantage", "for", "language", "development", "in", "the", "treatment", "group", "using", "standardized", "language", "assessments", ".", "We", "present", "the", "results", "from", "a", "re", "-", "analysis", "of", "their", "results", "to", "illustrate", "the", "importance", "of", "measuring", "communicative", "language", "acts", "(", "formally", "called", "\"", "speech", "acts", "\"", ")", ".", "Reanalysis", "confirmed", "that", "children", "in", "the", "MEHRIT", "group", "outperformed", "the", "community", "treatment", "group", "on", "measures", "of", "MLUm", ",", "number", "of", "utterances", "produced", ",", "and", "various", "speech", "act", "categories", ".", "The", "study", "underscores", "the", "importance", "of", "functional", "language", "measures", "in", "guiding", "and", "evaluating", "treatment", "for", "children", "with", "autism", ",", "and", "suggests", "that", "MEHRIT", "is", "effective", "in", "improving", "children", "'", "s", "use", "of", "language", "during", "parent", "-", "child", "interactions", "." ]	[ "Outcome_Mental", "Outcome_Other", "Intervention_Educational", "Intervention_Psychological", "Participant_Age", "Participant_Condition" ]
vitamin A - fortified coconut cooking oil is a Intervention_Pharmacological, serum retinol concentration is a Outcome_Physical, Filipino is a Participant_Condition, 4 - 7 years old is a Participant_Age, 542 is a Participant_Sample-size, 4 to 7 is a Participant_Age, vitamin A - fortified cooking oil is a Intervention_Pharmacological, unfortified cooking oil ration is a Intervention_Pharmacological, without cooking oil ration is a Intervention_Control, prevention is a Outcome_Other, control is a Outcome_Other	20685_task0	Sentence: The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Participant_Condition", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Outcome_Other", "O", "O", "O", "O", "O" ]	The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency .	[ "The", "effect", "of", "vitamin", "A", "-", "fortified", "coconut", "cooking", "oil", "on", "the", "serum", "retinol", "concentration", "of", "Filipino", "children", "4", "-", "7", "years", "old", ".", "A", "6-month", "intervention", "trial", "was", "conducted", "among", "542", "Filipino", "children", "aged", "4", "to", "7", "years", "to", "determine", "the", "effect", "of", "vitamin", "A", "-", "fortified", "coconut", "cooking", "oil", "intake", "on", "their", "vitamin", "A", "status", "and", "to", "identify", "factors", "that", "influence", "this", ".", "Children", "were", "randomly", "assigned", "to", "the", "Experimental", "group", ",", "with", "vitamin", "A", "-", "fortified", "cooking", "oil", "ration", ";", "to", "Control-1", "group", "with", "unfortified", "cooking", "oil", "ration", ";", "and", "to", "Control-2", "group", "without", "cooking", "oil", "ration", ".", "In", "all", "groups", ",", "children", "'", "s", "serum", "retinol", "concentration", "improved", ".", "Relative", "change", "in", "serum", "retinol", "concentration", "was", "significantly", "higher", "among", "the", "Experimental", "group", ",", "with", "one", "-", "third", "of", "total", "vitamin", "A", "intake", "coming", "from", "vitamin", "A", "-", "fortified", "cooking", "oil", "intake", ",", "than", "in", "the", "Control", "groups", ",", "with", "more", "than", "half", "of", "intake", "from", "other", "vitamin", "A", "-", "rich", "foods", ".", "Determinants", "of", "post", "-", "intervention", "serum", "retinol", "concentration", "included", "baseline", "serum", "retinol", "concentration", ",", "caregiver", "'", "s", "education", ",", "receipt", "of", "high", "-", "dose", "vitamin", "A", "capsule", ",", "interaction", "between", "consumption", "of", "vitamin", "A", "-", "fortified", "cooking", "oil", "and", "of", "other", "vitamin", "A", "-", "rich", "foods", ",", "and", "between", "households", "purchasing", "cooking", "oil", "and", "food", "expenditure", ".", "Intake", "of", "vitamin", "A", "-", "fortified", "cooking", "oil", "combined", "with", "vitamin", "A", "-", "rich", "foods", "was", "necessary", "to", "increase", "serum", "retinol", "concentration", ".", "It", "is", "recommended", "to", "vigorously", "promote", "the", "consumption", "of", "vitamin", "A", "-", "fortified", "cooking", "oil", "together", "with", "other", "vitamin", "A", "-", "rich", "sources", "to", "sustain", "the", "prevention", "and", "control", "of", "vitamin", "A", "deficiency", "." ]	[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Age", "Outcome_Other", "Participant_Sample-size" ]
vitamin A - fortified coconut cooking oil is a Intervention_Pharmacological, serum retinol concentration is a Outcome_Physical, Filipino is a Participant_Condition, 4 - 7 years old is a Participant_Age, 542 is a Participant_Sample-size, 4 to 7 is a Participant_Age, vitamin A - fortified cooking oil is a Intervention_Pharmacological, unfortified cooking oil ration is a Intervention_Pharmacological, without cooking oil ration is a Intervention_Control, prevention is a Outcome_Other, control is a Outcome_Other	20685_task1	Sentence: The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency . Instructions: please typing these entity words according to sentence: vitamin A - fortified coconut cooking oil, serum retinol concentration, Filipino, 4 - 7 years old, 542, 4 to 7, vitamin A - fortified cooking oil, unfortified cooking oil ration, without cooking oil ration, prevention, control Options: Intervention_Pharmacological, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other	[ "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Participant_Condition", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Outcome_Other", "O", "O", "O", "O", "O" ]	The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency .	[ "The", "effect", "of", "vitamin", "A", "-", "fortified", "coconut", "cooking", "oil", "on", "the", "serum", "retinol", "concentration", "of", "Filipino", "children", "4", "-", "7", "years", "old", ".", "A", "6-month", "intervention", "trial", "was", "conducted", "among", "542", "Filipino", "children", "aged", "4", "to", "7", "years", "to", "determine", "the", "effect", "of", "vitamin", "A", "-", "fortified", "coconut", "cooking", "oil", "intake", "on", "their", "vitamin", "A", "status", "and", "to", "identify", "factors", "that", "influence", "this", ".", "Children", "were", "randomly", "assigned", "to", "the", "Experimental", "group", ",", "with", "vitamin", "A", "-", "fortified", "cooking", "oil", "ration", ";", "to", "Control-1", "group", "with", "unfortified", "cooking", "oil", "ration", ";", "and", "to", "Control-2", "group", "without", "cooking", "oil", "ration", ".", "In", "all", "groups", ",", "children", "'", "s", "serum", "retinol", "concentration", "improved", ".", "Relative", "change", "in", "serum", "retinol", "concentration", "was", "significantly", "higher", "among", "the", "Experimental", "group", ",", "with", "one", "-", "third", "of", "total", "vitamin", "A", "intake", "coming", "from", "vitamin", "A", "-", "fortified", "cooking", "oil", "intake", ",", "than", "in", "the", "Control", "groups", ",", "with", "more", "than", "half", "of", "intake", "from", "other", "vitamin", "A", "-", "rich", "foods", ".", "Determinants", "of", "post", "-", "intervention", "serum", "retinol", "concentration", "included", "baseline", "serum", "retinol", "concentration", ",", "caregiver", "'", "s", "education", ",", "receipt", "of", "high", "-", "dose", "vitamin", "A", "capsule", ",", "interaction", "between", "consumption", "of", "vitamin", "A", "-", "fortified", "cooking", "oil", "and", "of", "other", "vitamin", "A", "-", "rich", "foods", ",", "and", "between", "households", "purchasing", "cooking", "oil", "and", "food", "expenditure", ".", "Intake", "of", "vitamin", "A", "-", "fortified", "cooking", "oil", "combined", "with", "vitamin", "A", "-", "rich", "foods", "was", "necessary", "to", "increase", "serum", "retinol", "concentration", ".", "It", "is", "recommended", "to", "vigorously", "promote", "the", "consumption", "of", "vitamin", "A", "-", "fortified", "cooking", "oil", "together", "with", "other", "vitamin", "A", "-", "rich", "sources", "to", "sustain", "the", "prevention", "and", "control", "of", "vitamin", "A", "deficiency", "." ]	[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Age", "Outcome_Other", "Participant_Sample-size" ]
vitamin A - fortified coconut cooking oil, serum retinol concentration, Filipino, 4 - 7 years old, 542, 4 to 7, vitamin A - fortified cooking oil, unfortified cooking oil ration, without cooking oil ration, prevention, control	20685_task2	Sentence: The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "B-Participant_Condition", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "B-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "I-Intervention_Control", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Outcome_Other", "O", "O", "O", "O", "O" ]	The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency .	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lymphoma is an umlsterm, malignant lymphoma is an umlsterm, thymus is an umlsterm, spleen is an umlsterm, Waldeyer 's is an umlsterm, appendix is an umlsterm, secondary is an umlsterm, lymphoproliferative disease is an umlsterm, lymphomas is an umlsterm, non - Hodgkin lymphomas is an umlsterm, Hodgkin 's is an umlsterm, disease is an umlsterm, NHL is an umlsterm, malignant is an umlsterm, forms is an umlsterm, MALT lymphomas is an umlsterm, growth is an umlsterm, pseudolymphomas is an umlsterm, tumor is an umlsterm, growth is an umlsterm, time is an umlsterm, Lymphoma is an umlsterm, classification is an umlsterm, incidence is an umlsterm, classification is an umlsterm, Secondary is an umlsterm, NHL is an umlsterm, disease is an umlsterm, lymphomas is an umlsterm, Secondary is an umlsterm, AIDS is an umlsterm, patients is an umlsterm, AIDS - related lymphoma is an umlsterm, imaging is an umlsterm, lymphoma is an umlsterm	DerRadiologe.70370027.eng.abstr_task0	Sentence: Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region .	[ "Primary", "extranodal", "lymphoma", "manifestation", "in", "the", "narrow", "sense", "is", "the", "term", "used", "to", "define", "the", "primary", "organ", "manifestation", "of", "a", "malignant", "lymphoma", ",", "excluding", "the", "thymus", ",", "spleen", ",", "Waldeyer", "'s", "tonsillar", "ring", ",", "the", "appendix", "and", "Peyer", "'s", "patches", ".", "However", ",", "in", "the", "clinical", "routine", "the", "term", "is", "also", "used", "for", "the", "secondary", "organ", "manifestation", "of", "underlying", "lymphoproliferative", "disease", ".", "Primary", "extranodal", "lymphomas", "are", "mainly", "non", "-", "Hodgkin", "lymphomas", ";", "there", "is", "primary", "extranodal", "manifestation", "of", "Hodgkin", "'s", "disease", "in", "only", "about", "1", "%", "of", "the", "cases", ".", "Among", "the", "extranodal", "NHL", ",", "the", "highly", "malignant", "forms", "predominate", ".", "A", "major", "exception", "is", "MALT", "lymphomas", ",", "which", "mainly", "show", "low", "slow", "growth", ".", "In", "the", "past", ",", "they", "were", "considered", "to", "be", "pseudolymphomas", "because", "of", "their", "slow", "and", "localized", "tumor", "growth", ".", "They", "were", "included", "as", "an", "entity", "of", "their", "own", "for", "the", "first", "time", "in", "the", "Revised", "European", "American", "Lymphoma", "(", "REAL", ")", "classification", "of", "1994", ".", "The", "incidence", "data", "vary", "between", "10", "%", "and", "25", "%", "for", "primary", "extranodal", "manifestation", ".", "The", "major", "reason", "for", "this", "is", "the", "difference", "in", "extranodal", "regions", "because", "of", "classification", ".", "Secondary", "organ", "involvment", "of", "an", "NHL", "occurs", "in", "up", "to", "40", "%", "of", "the", "cases", "in", "the", "long", "-", "term", "course", "of", "the", "disease", "in", "primary", "nodal", "lymphomas", ".", "Secondary", "organ", "involvment", "is", "frequently", "diagnosed", "in", "AIDS", "patients", "who", "develop", "an", "AIDS", "-", "related", "lymphoma", "(", "85", "%", "of", "cases", ")", ".", "The", "following", "contribution", "reports", "on", "the", "radiological", "imaging", "of", "extranodal", "lymphoma", "manifestation", "in", "the", "thoracoabdominal", "region", "." ]	[ "umlsterm" ]
lymphoma is an umlsterm, malignant lymphoma is an umlsterm, thymus is an umlsterm, spleen is an umlsterm, Waldeyer 's is an umlsterm, appendix is an umlsterm, secondary is an umlsterm, lymphoproliferative disease is an umlsterm, lymphomas is an umlsterm, non - Hodgkin lymphomas is an umlsterm, Hodgkin 's is an umlsterm, disease is an umlsterm, NHL is an umlsterm, malignant is an umlsterm, forms is an umlsterm, MALT lymphomas is an umlsterm, growth is an umlsterm, pseudolymphomas is an umlsterm, tumor is an umlsterm, growth is an umlsterm, time is an umlsterm, Lymphoma is an umlsterm, classification is an umlsterm, incidence is an umlsterm, classification is an umlsterm, Secondary is an umlsterm, NHL is an umlsterm, disease is an umlsterm, lymphomas is an umlsterm, Secondary is an umlsterm, AIDS is an umlsterm, patients is an umlsterm, AIDS - related lymphoma is an umlsterm, imaging is an umlsterm, lymphoma is an umlsterm	DerRadiologe.70370027.eng.abstr_task1	Sentence: Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region . Instructions: please typing these entity words according to sentence: lymphoma, malignant lymphoma, thymus, spleen, Waldeyer 's, appendix, secondary, lymphoproliferative disease, lymphomas, non - Hodgkin lymphomas, Hodgkin 's, disease, NHL, malignant, forms, MALT lymphomas, growth, pseudolymphomas, tumor, growth, time, Lymphoma, classification, incidence, classification, Secondary, NHL, disease, lymphomas, Secondary, AIDS, patients, AIDS - related lymphoma, imaging, lymphoma Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region .	[ "Primary", "extranodal", "lymphoma", "manifestation", "in", "the", "narrow", "sense", "is", "the", "term", "used", "to", "define", "the", "primary", "organ", "manifestation", "of", "a", "malignant", "lymphoma", ",", "excluding", "the", "thymus", ",", "spleen", ",", "Waldeyer", "'s", "tonsillar", "ring", ",", "the", "appendix", "and", "Peyer", "'s", "patches", ".", "However", ",", "in", "the", "clinical", "routine", "the", "term", "is", "also", "used", "for", "the", "secondary", "organ", "manifestation", "of", "underlying", "lymphoproliferative", "disease", ".", "Primary", "extranodal", "lymphomas", "are", "mainly", "non", "-", "Hodgkin", "lymphomas", ";", "there", "is", "primary", "extranodal", "manifestation", "of", "Hodgkin", "'s", "disease", "in", "only", "about", "1", "%", "of", "the", "cases", ".", "Among", "the", "extranodal", "NHL", ",", "the", "highly", "malignant", "forms", "predominate", ".", "A", "major", "exception", "is", "MALT", "lymphomas", ",", "which", "mainly", "show", "low", "slow", "growth", ".", "In", "the", "past", ",", "they", "were", "considered", "to", "be", "pseudolymphomas", "because", "of", "their", "slow", "and", "localized", "tumor", "growth", ".", "They", "were", "included", "as", "an", "entity", "of", "their", "own", "for", "the", "first", "time", "in", "the", "Revised", "European", "American", "Lymphoma", "(", "REAL", ")", "classification", "of", "1994", ".", "The", "incidence", "data", "vary", "between", "10", "%", "and", "25", "%", "for", "primary", "extranodal", "manifestation", ".", "The", "major", "reason", "for", "this", "is", "the", "difference", "in", "extranodal", "regions", "because", "of", "classification", ".", "Secondary", "organ", "involvment", "of", "an", "NHL", "occurs", "in", "up", "to", "40", "%", "of", "the", "cases", "in", "the", "long", "-", "term", "course", "of", "the", "disease", "in", "primary", "nodal", "lymphomas", ".", "Secondary", "organ", "involvment", "is", "frequently", "diagnosed", "in", "AIDS", "patients", "who", "develop", "an", "AIDS", "-", "related", "lymphoma", "(", "85", "%", "of", "cases", ")", ".", "The", "following", "contribution", "reports", "on", "the", "radiological", "imaging", "of", "extranodal", "lymphoma", "manifestation", "in", "the", "thoracoabdominal", "region", "." ]	[ "umlsterm" ]
lymphoma, malignant lymphoma, thymus, spleen, Waldeyer 's, appendix, secondary, lymphoproliferative disease, lymphomas, non - Hodgkin lymphomas, Hodgkin 's, disease, NHL, malignant, forms, MALT lymphomas, growth, pseudolymphomas, tumor, growth, time, Lymphoma, classification, incidence, classification, Secondary, NHL, disease, lymphomas, Secondary, AIDS, patients, AIDS - related lymphoma, imaging, lymphoma	DerRadiologe.70370027.eng.abstr_task2	Sentence: Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region .	[ "Primary", "extranodal", "lymphoma", "manifestation", "in", "the", "narrow", "sense", "is", "the", "term", "used", "to", "define", "the", "primary", "organ", "manifestation", "of", "a", "malignant", "lymphoma", ",", "excluding", "the", "thymus", ",", "spleen", ",", "Waldeyer", "'s", "tonsillar", "ring", ",", "the", "appendix", "and", "Peyer", "'s", "patches", ".", "However", ",", "in", "the", "clinical", "routine", "the", "term", "is", "also", "used", "for", "the", "secondary", "organ", "manifestation", "of", "underlying", "lymphoproliferative", "disease", ".", "Primary", "extranodal", "lymphomas", "are", "mainly", "non", "-", "Hodgkin", "lymphomas", ";", "there", "is", "primary", "extranodal", "manifestation", "of", "Hodgkin", "'s", "disease", "in", "only", "about", "1", "%", "of", "the", "cases", ".", "Among", "the", "extranodal", "NHL", ",", "the", "highly", "malignant", "forms", "predominate", ".", "A", "major", "exception", "is", "MALT", "lymphomas", ",", "which", "mainly", "show", "low", "slow", "growth", ".", "In", "the", "past", ",", "they", "were", "considered", "to", "be", "pseudolymphomas", "because", "of", "their", "slow", "and", "localized", "tumor", "growth", ".", "They", "were", "included", "as", "an", "entity", "of", "their", "own", "for", "the", "first", "time", "in", "the", "Revised", "European", "American", "Lymphoma", "(", "REAL", ")", "classification", "of", "1994", ".", "The", "incidence", "data", "vary", "between", "10", "%", "and", "25", "%", "for", "primary", "extranodal", "manifestation", ".", "The", "major", "reason", "for", "this", "is", "the", "difference", "in", "extranodal", "regions", "because", "of", "classification", ".", "Secondary", "organ", "involvment", "of", "an", "NHL", "occurs", "in", "up", "to", "40", "%", "of", "the", "cases", "in", "the", "long", "-", "term", "course", "of", "the", "disease", "in", "primary", "nodal", "lymphomas", ".", "Secondary", "organ", "involvment", "is", "frequently", "diagnosed", "in", "AIDS", "patients", "who", "develop", "an", "AIDS", "-", "related", "lymphoma", "(", "85", "%", "of", "cases", ")", ".", "The", "following", "contribution", "reports", "on", "the", "radiological", "imaging", "of", "extranodal", "lymphoma", "manifestation", "in", "the", "thoracoabdominal", "region", "." ]	[ "umlsterm" ]
etiology is an umlsterm, patients is an umlsterm, accident is an umlsterm, symptoms is an umlsterm, range of motion is an umlsterm, spine is an umlsterm, recognition is an umlsterm, surgery is an umlsterm, contrast is an umlsterm, treatment is an umlsterm, patients is an umlsterm, regression is an umlsterm, symptoms is an umlsterm, patients is an umlsterm, range of motion is an umlsterm, spine is an umlsterm, pain is an umlsterm, patients is an umlsterm, surgical treatment is an umlsterm, complications is an umlsterm	DerUnfallchirurg.81010100.eng.abstr_task0	Sentence: The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications .	[ "The", "etiology", "of", "os", "odontoideum", "is", "still", "controversial", ".", "In", "most", "patients", ",", "it", "is", "found", "by", "accident", "because", "of", "neurological", "symptoms", "and", "/", "or", "painful", "range", "of", "motion", "of", "the", "cervical", "spine", ".", "Upon", "recognition", "of", "the", "os", "odontoideum", ",", "it", "is", "unknown", "whether", "or", "not", "immediate", "surgery", "is", "beneficial", ".", "This", "is", "in", "contrast", "to", "an", "\"", "unstable", "\"", "os", "odontoideum", ",", "which", "could", "result", "in", "atlantoaxial", "instability", "or", "compression", "of", "the", "myelon", ".", "In", "this", "study", ",", "we", "present", "the", "results", "of", "our", "treatment", "of", "four", "patients", "with", "an", "unstable", "os", "odontoideum", ".", "In", "all", "four", "cases", ",", "a", "C1", "-", "2", "fusion", "was", "performed", "(", "3", "x", "Magerl", "/", "Seemann", ",", "1", "Gallie", "-", "Brooks", ")", ".", "Postoperatively", ",", "we", "found", "a", "complete", "regression", "of", "neurological", "symptoms", "in", "three", "patients", "and", "one", "was", "significantly", "improved", ".", "The", "range", "of", "motion", "of", "the", "cervical", "spine", "was", "free", "of", "pain", "in", "all", "patients", ".", "As", "a", "result", ",", "we", "strongly", "support", "immediate", "surgical", "treatment", "of", "an", "unstable", "os", "odontoideum", "in", "order", "to", "prevent", "severe", "and", "life", "-", "threatening", "neurological", "complications", "." ]	[ "umlsterm" ]
etiology is an umlsterm, patients is an umlsterm, accident is an umlsterm, symptoms is an umlsterm, range of motion is an umlsterm, spine is an umlsterm, recognition is an umlsterm, surgery is an umlsterm, contrast is an umlsterm, treatment is an umlsterm, patients is an umlsterm, regression is an umlsterm, symptoms is an umlsterm, patients is an umlsterm, range of motion is an umlsterm, spine is an umlsterm, pain is an umlsterm, patients is an umlsterm, surgical treatment is an umlsterm, complications is an umlsterm	DerUnfallchirurg.81010100.eng.abstr_task1	Sentence: The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications . Instructions: please typing these entity words according to sentence: etiology, patients, accident, symptoms, range of motion, spine, recognition, surgery, contrast, treatment, patients, regression, symptoms, patients, range of motion, spine, pain, patients, surgical treatment, complications Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications .	[ "The", "etiology", "of", "os", "odontoideum", "is", "still", "controversial", ".", "In", "most", "patients", ",", "it", "is", "found", "by", "accident", "because", "of", "neurological", "symptoms", "and", "/", "or", "painful", "range", "of", "motion", "of", "the", "cervical", "spine", ".", "Upon", "recognition", "of", "the", "os", "odontoideum", ",", "it", "is", "unknown", "whether", "or", "not", "immediate", "surgery", "is", "beneficial", ".", "This", "is", "in", "contrast", "to", "an", "\"", "unstable", "\"", "os", "odontoideum", ",", "which", "could", "result", "in", "atlantoaxial", "instability", "or", "compression", "of", "the", "myelon", ".", "In", "this", "study", ",", "we", "present", "the", "results", "of", "our", "treatment", "of", "four", "patients", "with", "an", "unstable", "os", "odontoideum", ".", "In", "all", "four", "cases", ",", "a", "C1", "-", "2", "fusion", "was", "performed", "(", "3", "x", "Magerl", "/", "Seemann", ",", "1", "Gallie", "-", "Brooks", ")", ".", "Postoperatively", ",", "we", "found", "a", "complete", "regression", "of", "neurological", "symptoms", "in", "three", "patients", "and", "one", "was", "significantly", "improved", ".", "The", "range", "of", "motion", "of", "the", "cervical", "spine", "was", "free", "of", "pain", "in", "all", "patients", ".", "As", "a", "result", ",", "we", "strongly", "support", "immediate", "surgical", "treatment", "of", "an", "unstable", "os", "odontoideum", "in", "order", "to", "prevent", "severe", "and", "life", "-", "threatening", "neurological", "complications", "." ]	[ "umlsterm" ]
etiology, patients, accident, symptoms, range of motion, spine, recognition, surgery, contrast, treatment, patients, regression, symptoms, patients, range of motion, spine, pain, patients, surgical treatment, complications	DerUnfallchirurg.81010100.eng.abstr_task2	Sentence: The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications .	[ "The", "etiology", "of", "os", "odontoideum", "is", "still", "controversial", ".", "In", "most", "patients", ",", "it", "is", "found", "by", "accident", "because", "of", "neurological", "symptoms", "and", "/", "or", "painful", "range", "of", "motion", "of", "the", "cervical", "spine", ".", "Upon", "recognition", "of", "the", "os", "odontoideum", ",", "it", "is", "unknown", "whether", "or", "not", "immediate", "surgery", "is", "beneficial", ".", "This", "is", "in", "contrast", "to", "an", "\"", "unstable", "\"", "os", "odontoideum", ",", "which", "could", "result", "in", "atlantoaxial", "instability", "or", "compression", "of", "the", "myelon", ".", "In", "this", "study", ",", "we", "present", "the", "results", "of", "our", "treatment", "of", "four", "patients", "with", "an", "unstable", "os", "odontoideum", ".", "In", "all", "four", "cases", ",", "a", "C1", "-", "2", "fusion", "was", "performed", "(", "3", "x", "Magerl", "/", "Seemann", ",", "1", "Gallie", "-", "Brooks", ")", ".", "Postoperatively", ",", "we", "found", "a", "complete", "regression", "of", "neurological", "symptoms", "in", "three", "patients", "and", "one", "was", "significantly", "improved", ".", "The", "range", "of", "motion", "of", "the", "cervical", "spine", "was", "free", "of", "pain", "in", "all", "patients", ".", "As", "a", "result", ",", "we", "strongly", "support", "immediate", "surgical", "treatment", "of", "an", "unstable", "os", "odontoideum", "in", "order", "to", "prevent", "severe", "and", "life", "-", "threatening", "neurological", "complications", "." ]	[ "umlsterm" ]
JNK is a protein, SAPK is a protein, MEKK1 is a protein	1.0alpha7.train.121_task0	Sentence: JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein	[ "B-protein", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]	JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro	[ "JNK", "/", "SAPK", "Binds", "and", "Phosphorylates", "a", "MEKK1", "Fragment", "In", "Vitro" ]	[ "protein" ]
JNK is a protein, SAPK is a protein, MEKK1 is a protein	1.0alpha7.train.121_task1	Sentence: JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro Instructions: please typing these entity words according to sentence: JNK, SAPK, MEKK1 Options: protein	[ "B-protein", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]	JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro	[ "JNK", "/", "SAPK", "Binds", "and", "Phosphorylates", "a", "MEKK1", "Fragment", "In", "Vitro" ]	[ "protein" ]
JNK, SAPK, MEKK1	1.0alpha7.train.121_task2	Sentence: JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro Instructions: please extract entity words from the input sentence	[ "B-protein", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]	JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro	[ "JNK", "/", "SAPK", "Binds", "and", "Phosphorylates", "a", "MEKK1", "Fragment", "In", "Vitro" ]	[ "protein" ]
glutaminase is a GENE-N, synthase is a GENE-N, glutamate is a CHEMICAL	17373776_task0	Sentence: Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL	[ "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain.	[ "Activation", "and", "coupling", "of", "the", "glutaminase", "and", "synthase", "reaction", "of", "glutamate", "synthase", "is", "mediated", "by", "E1013", "of", "the", "ferredoxin", "-", "dependent", "enzyme", ",", "belonging", "to", "loop", "4", "of", "the", "synthase", "domain", "." ]	[ "GENE-N", "CHEMICAL" ]
glutaminase is a GENE-N, synthase is a GENE-N, glutamate is a CHEMICAL	17373776_task1	Sentence: Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain. Instructions: please typing these entity words according to sentence: glutaminase, synthase, glutamate Options: GENE-N, CHEMICAL	[ "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain.	[ "Activation", "and", "coupling", "of", "the", "glutaminase", "and", "synthase", "reaction", "of", "glutamate", "synthase", "is", "mediated", "by", "E1013", "of", "the", "ferredoxin", "-", "dependent", "enzyme", ",", "belonging", "to", "loop", "4", "of", "the", "synthase", "domain", "." ]	[ "GENE-N", "CHEMICAL" ]
glutaminase, synthase, glutamate	17373776_task2	Sentence: Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain.	[ "Activation", "and", "coupling", "of", "the", "glutaminase", "and", "synthase", "reaction", "of", "glutamate", "synthase", "is", "mediated", "by", "E1013", "of", "the", "ferredoxin", "-", "dependent", "enzyme", ",", "belonging", "to", "loop", "4", "of", "the", "synthase", "domain", "." ]	[ "GENE-N", "CHEMICAL" ]
activator protein ( AP)-1 is a Entity, nuclear factor - kappaB is a Entity, CD28 is a Protein, acidic sphingomyelinase is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, IL-2 is a Protein, B7 is a Protein, activator protein-1 ( AP-1 ) is a Entity, nuclear factor - kappaB ( NF - kappaB ) complexes is a Entity, CD28 is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, IL-2 is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, acidic sphingomyelinase is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, AP-1 is a Entity, acidic sphingomyelinase is a Protein	75_task0	Sentence: Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals. A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways. 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A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways.	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activator protein ( AP)-1 is a Entity, nuclear factor - kappaB is a Entity, CD28 is a Protein, acidic sphingomyelinase is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, IL-2 is a Protein, B7 is a Protein, activator protein-1 ( AP-1 ) is a Entity, nuclear factor - kappaB ( NF - kappaB ) complexes is a Entity, CD28 is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, IL-2 is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, acidic sphingomyelinase is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, AP-1 is a Entity, acidic sphingomyelinase is a Protein	75_task1	Sentence: Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals. A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways. 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A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways.	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activator protein ( AP)-1, nuclear factor - kappaB, CD28, acidic sphingomyelinase, CD28, CD28, CD28, CD28, CD28, CD28, IL-2, B7, activator protein-1 ( AP-1 ), nuclear factor - kappaB ( NF - kappaB ) complexes, CD28, AP-1, NF - kappaB, IL-2, AP-1, NF - kappaB, acidic sphingomyelinase, AP-1, NF - kappaB, AP-1, acidic sphingomyelinase	75_task2	Sentence: Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals. A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways. 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A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways.	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Knochentumor is an umlsterm, Patienten is an umlsterm, Lebensdekade is an umlsterm, Epiphysen is an umlsterm, Femurkopf is an umlsterm, Radiologisch is an umlsterm, Tumorzellen is an umlsterm, Zytoplasma is an umlsterm, Beobachtungen is an umlsterm, Knochentumor - Registers is an umlsterm, Altersverteilung is an umlsterm, radiologischen is an umlsterm, Lebensdekade is an umlsterm, Femur is an umlsterm, Os ilium is an umlsterm, Hand is an umlsterm, Osteosarkom is an umlsterm, Chondrosarkom is an umlsterm, Epiphyse is an umlsterm, Skeletts is an umlsterm, Tumors is an umlsterm, Diagnosefindung is an umlsterm	DerPathologe.00210449.ger.abstr_task0	Sentence: Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung .	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Knochentumor is an umlsterm, Patienten is an umlsterm, Lebensdekade is an umlsterm, Epiphysen is an umlsterm, Femurkopf is an umlsterm, Radiologisch is an umlsterm, Tumorzellen is an umlsterm, Zytoplasma is an umlsterm, Beobachtungen is an umlsterm, Knochentumor - Registers is an umlsterm, Altersverteilung is an umlsterm, radiologischen is an umlsterm, Lebensdekade is an umlsterm, Femur is an umlsterm, Os ilium is an umlsterm, Hand is an umlsterm, Osteosarkom is an umlsterm, Chondrosarkom is an umlsterm, Epiphyse is an umlsterm, Skeletts is an umlsterm, Tumors is an umlsterm, Diagnosefindung is an umlsterm	DerPathologe.00210449.ger.abstr_task1	Sentence: Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung . Instructions: please typing these entity words according to sentence: Knochentumor, Patienten, Lebensdekade, Epiphysen, Femurkopf, Radiologisch, Tumorzellen, Zytoplasma, Beobachtungen, Knochentumor - Registers, Altersverteilung, radiologischen, Lebensdekade, Femur, Os ilium, Hand, Osteosarkom, Chondrosarkom, Epiphyse, Skeletts, Tumors, Diagnosefindung Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung .	[ "Das", "Klarzellchondrosarkom", "ist", "ein", "seltener", "niedrigmaligner", "Knochentumor", ".", "Betroffen", "sind", "v.", "a.", "Patienten", "in", "der", "3", ".", "und", "4", ".", "Lebensdekade", ".", "Bevorzugte", "Lokalisation", "sind", "die", "Epiphysen", "langer", "Roehrenknochen", ",", "insbesondere", "der", "Femurkopf", ".", "Radiologisch", "imponiert", "es", "meist", "als", "eine", "epiphysaer", "gelegene", ",", "scharf", "begrenzte", "lytische", "Laesion", ".", "Histologisch", "charakteristisch", "sind", "die", "grossen", "Tumorzellen", "mit", "deutlichen", "Zellgrenzen", "und", "einem", "hellen", "Zytoplasma", ".", "Daneben", "finden", "sich", "auch", "Areale", "mit", "dem", "histologischen", "Bild", "eines", "konventionellen", "Chondrosarkoms", "sowie", "unterschiedlich", "breite", ",", "z", ".", "T.", "mineralisierte", "trabekulaere", "Osteoidformationen", ".", "Anhand", "von", "16", "Faellen", "mit", "Klarzellchondrosarkom", "werden", "die", "Erfahrungen", "und", "Beobachtungen", "des", "Hamburger", "Knochentumor", "-", "Registers", "dargestellt", ".", "Die", "Faelle", "wurden", "nach", "Altersverteilung", ",", "Lokalisation", "sowie", "radiologischen", "und", "pathomorphologischen", "Kriterien", "untersucht", ".", "Das", "Hauptmanifestationsalter", "lag", "innerhalb", "der", "5.-7", ".", "Lebensdekade", ".", "Das", "proximale", "Femur", "stellte", "den", "Hauptlokalisationsort", "dar", ".", "Daneben", "fanden", "sich", "auch", "eher", "seltene", "Manifestationen", "im", "Bereich", "der", "Rippe", ",", "Os", "ilium", "und", "Grundphalanx", "der", "Hand", ".", "In", "50", "%", "der", "Faelle", "wurde", "auswaertig", "zunaechst", "differenzialdiagnostisch", "ein", "hochmalignes", "Osteosarkom", "oder", "ein", "Chondrosarkom", "diskutiert", ".", "Da", "das", "Klarzellchondrosarkom", "ausser", "in", "der", "Epiphyse", "des", "proximalen", "Femurs", "auch", "an", "anderen", ",", "eher", "ungewoehnlichen", "Stellen", "des", "Skeletts", "auftreten", "kann", ",", "ist", "die", "Kenntnis", "der", "Histomorphologie", "dieses", "Tumors", "von", "entscheidender", "Bedeutung", "fuer", "die", "Diagnosefindung", "." ]	[ "umlsterm" ]
Knochentumor, Patienten, Lebensdekade, Epiphysen, Femurkopf, Radiologisch, Tumorzellen, Zytoplasma, Beobachtungen, Knochentumor - Registers, Altersverteilung, radiologischen, Lebensdekade, Femur, Os ilium, Hand, Osteosarkom, Chondrosarkom, Epiphyse, Skeletts, Tumors, Diagnosefindung	DerPathologe.00210449.ger.abstr_task2	Sentence: Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung .	[ "Das", "Klarzellchondrosarkom", "ist", "ein", "seltener", "niedrigmaligner", "Knochentumor", ".", "Betroffen", "sind", "v.", "a.", "Patienten", "in", "der", "3", ".", "und", "4", ".", "Lebensdekade", ".", "Bevorzugte", "Lokalisation", "sind", "die", "Epiphysen", "langer", "Roehrenknochen", ",", "insbesondere", "der", "Femurkopf", ".", "Radiologisch", "imponiert", "es", "meist", "als", "eine", "epiphysaer", "gelegene", ",", "scharf", "begrenzte", "lytische", "Laesion", ".", "Histologisch", "charakteristisch", "sind", "die", "grossen", "Tumorzellen", "mit", "deutlichen", "Zellgrenzen", "und", "einem", "hellen", "Zytoplasma", ".", "Daneben", "finden", "sich", "auch", "Areale", "mit", "dem", "histologischen", "Bild", "eines", "konventionellen", "Chondrosarkoms", "sowie", "unterschiedlich", "breite", ",", "z", ".", "T.", "mineralisierte", "trabekulaere", "Osteoidformationen", ".", "Anhand", "von", "16", "Faellen", "mit", "Klarzellchondrosarkom", "werden", "die", "Erfahrungen", "und", "Beobachtungen", "des", "Hamburger", "Knochentumor", "-", "Registers", "dargestellt", ".", "Die", "Faelle", "wurden", "nach", "Altersverteilung", ",", "Lokalisation", "sowie", "radiologischen", "und", "pathomorphologischen", "Kriterien", "untersucht", ".", "Das", "Hauptmanifestationsalter", "lag", "innerhalb", "der", "5.-7", ".", "Lebensdekade", ".", "Das", "proximale", "Femur", "stellte", "den", "Hauptlokalisationsort", "dar", ".", "Daneben", "fanden", "sich", "auch", "eher", "seltene", "Manifestationen", "im", "Bereich", "der", "Rippe", ",", "Os", "ilium", "und", "Grundphalanx", "der", "Hand", ".", "In", "50", "%", "der", "Faelle", "wurde", "auswaertig", "zunaechst", "differenzialdiagnostisch", "ein", "hochmalignes", "Osteosarkom", "oder", "ein", "Chondrosarkom", "diskutiert", ".", "Da", "das", "Klarzellchondrosarkom", "ausser", "in", "der", "Epiphyse", "des", "proximalen", "Femurs", "auch", "an", "anderen", ",", "eher", "ungewoehnlichen", "Stellen", "des", "Skeletts", "auftreten", "kann", ",", "ist", "die", "Kenntnis", "der", "Histomorphologie", "dieses", "Tumors", "von", "entscheidender", "Bedeutung", "fuer", "die", "Diagnosefindung", "." ]	[ "umlsterm" ]
Krankenhausinformationssystem is an umlsterm, Heinrich - Heine - Universitaet is an umlsterm	DerGynaekologe.00330172.ger.abstr_task0	Sentence: Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik .	[ "Vor", "5", "Jahren", "wurde", "zum", "erstenmal", "ein", "neues", "Krankenhausinformationssystem", "an", "der", "Heinrich", "-", "Heine", "-", "Universitaet", "Duesseldorf", "eingefuehrt", ".", "Dieser", "Beitrag", "beschreibt", "die", "Voraussetzungen", "und", "die", "Vorgehensweise", "bei", "der", "Einfuehrung", "in", "einer", "Klinik", "." ]	[ "umlsterm" ]
Krankenhausinformationssystem is an umlsterm, Heinrich - Heine - Universitaet is an umlsterm	DerGynaekologe.00330172.ger.abstr_task1	Sentence: Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik . Instructions: please typing these entity words according to sentence: Krankenhausinformationssystem, Heinrich - Heine - Universitaet Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik .	[ "Vor", "5", "Jahren", "wurde", "zum", "erstenmal", "ein", "neues", "Krankenhausinformationssystem", "an", "der", "Heinrich", "-", "Heine", "-", "Universitaet", "Duesseldorf", "eingefuehrt", ".", "Dieser", "Beitrag", "beschreibt", "die", "Voraussetzungen", "und", "die", "Vorgehensweise", "bei", "der", "Einfuehrung", "in", "einer", "Klinik", "." ]	[ "umlsterm" ]
Krankenhausinformationssystem, Heinrich - Heine - Universitaet	DerGynaekologe.00330172.ger.abstr_task2	Sentence: Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik .	[ "Vor", "5", "Jahren", "wurde", "zum", "erstenmal", "ein", "neues", "Krankenhausinformationssystem", "an", "der", "Heinrich", "-", "Heine", "-", "Universitaet", "Duesseldorf", "eingefuehrt", ".", "Dieser", "Beitrag", "beschreibt", "die", "Voraussetzungen", "und", "die", "Vorgehensweise", "bei", "der", "Einfuehrung", "in", "einer", "Klinik", "." ]	[ "umlsterm" ]
GTPase is a protein-family, Ras is a protein-family, GTP - bound form of Ras is a protein	1.0alpha7.train.574_task0	Sentence: Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-family, protein	[ "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "O" ]	Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active.	[ " ", "Regulation", "of", "the", "GTPase", "activity", "of", " ", "Ras", "is", "crucial", ",", "because", "only", "the", " ", "GTP", "-", "bound", "form", "of", " ", "Ras", "is", "active", ".", " " ]	[ "protein", "protein-family", "chemical" ]
GTPase is a protein-family, Ras is a protein-family, GTP - bound form of Ras is a protein	1.0alpha7.train.574_task1	Sentence: Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active. Instructions: please typing these entity words according to sentence: GTPase, Ras, GTP - bound form of Ras Options: protein-family, protein	[ "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "O" ]	Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active.	[ " ", "Regulation", "of", "the", "GTPase", "activity", "of", " ", "Ras", "is", "crucial", ",", "because", "only", "the", " ", "GTP", "-", "bound", "form", "of", " ", "Ras", "is", "active", ".", " " ]	[ "protein", "protein-family", "chemical" ]
GTPase, Ras, GTP - bound form of Ras	1.0alpha7.train.574_task2	Sentence: Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-protein-family", "O", "O", "O", "B-protein-family", "O", "O", "O", "O", "O", "O", "O", "B-protein", "I-protein", "I-protein", "I-protein", "I-protein", "I-protein", "I-protein", "O", "O", "O", "O" ]	Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active.	[ " ", "Regulation", "of", "the", "GTPase", "activity", "of", " ", "Ras", "is", "crucial", ",", "because", "only", "the", " ", "GTP", "-", "bound", "form", "of", " ", "Ras", "is", "active", ".", " " ]	[ "protein", "protein-family", "chemical" ]
therapy is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, techniques is an umlsterm, psychoanalysis is an umlsterm, techniques is an umlsterm, nature is an umlsterm, human is an umlsterm, character is an umlsterm, human is an umlsterm, object relation is an umlsterm, psychologists is an umlsterm, love is an umlsterm, human is an umlsterm, guidelines is an umlsterm, techniques is an umlsterm, psychoanalytical therapy is an umlsterm	ForumDerPsychoanalyse.80140139.eng.abstr_task0	Sentence: Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy .	[ "Classical", "insight", "therapy", ",", "derived", "from", "Freud", ",", "and", "`", "maternal", "'", "holding", "therapy", ",", "derived", "from", "Balint", ",", "Winnicott", "and", "others", ",", "are", "two", "contrasting", "treatment", "techniques", "in", "psychoanalysis", ".", "The", "authors", "believe", "that", "each", "of", "these", "two", "techniques", "presupposes", "specific", "philosophical", "basic", "assumptions", "about", "the", "nature", "of", "human", "beings", ".", "The", "position", "of", "Freud", "is", "that", "of", "the", "basically", "traumatic", "character", "of", "human", "experience", ".", "The", "contra", "-", "position", "of", "the", "object", "relation", "psychologists", "stipulates", "the", "priority", "of", "love", "in", "human", "experience", ".", "These", "assumptions", "seem", "to", "be", "more", "latent", "than", "overt", "guidelines", "of", "therapeutical", "techniques", "and", "therefore", "their", "reconstruction", "and", "reformulation", "have", "important", "implications", "for", "psychoanalytical", "therapy", "." ]	[ "umlsterm" ]
therapy is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, techniques is an umlsterm, psychoanalysis is an umlsterm, techniques is an umlsterm, nature is an umlsterm, human is an umlsterm, character is an umlsterm, human is an umlsterm, object relation is an umlsterm, psychologists is an umlsterm, love is an umlsterm, human is an umlsterm, guidelines is an umlsterm, techniques is an umlsterm, psychoanalytical therapy is an umlsterm	ForumDerPsychoanalyse.80140139.eng.abstr_task1	Sentence: Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy . Instructions: please typing these entity words according to sentence: therapy, therapy, treatment, techniques, psychoanalysis, techniques, nature, human, character, human, object relation, psychologists, love, human, guidelines, techniques, psychoanalytical therapy Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy .	[ "Classical", "insight", "therapy", ",", "derived", "from", "Freud", ",", "and", "`", "maternal", "'", "holding", "therapy", ",", "derived", "from", "Balint", ",", "Winnicott", "and", "others", ",", "are", "two", "contrasting", "treatment", "techniques", "in", "psychoanalysis", ".", "The", "authors", "believe", "that", "each", "of", "these", "two", "techniques", "presupposes", "specific", "philosophical", "basic", "assumptions", "about", "the", "nature", "of", "human", "beings", ".", "The", "position", "of", "Freud", "is", "that", "of", "the", "basically", "traumatic", "character", "of", "human", "experience", ".", "The", "contra", "-", "position", "of", "the", "object", "relation", "psychologists", "stipulates", "the", "priority", "of", "love", "in", "human", "experience", ".", "These", "assumptions", "seem", "to", "be", "more", "latent", "than", "overt", "guidelines", "of", "therapeutical", "techniques", "and", "therefore", "their", "reconstruction", "and", "reformulation", "have", "important", "implications", "for", "psychoanalytical", "therapy", "." ]	[ "umlsterm" ]
therapy, therapy, treatment, techniques, psychoanalysis, techniques, nature, human, character, human, object relation, psychologists, love, human, guidelines, techniques, psychoanalytical therapy	ForumDerPsychoanalyse.80140139.eng.abstr_task2	Sentence: Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O" ]	Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy .	[ "Classical", "insight", "therapy", ",", "derived", "from", "Freud", ",", "and", "`", "maternal", "'", "holding", "therapy", ",", "derived", "from", "Balint", ",", "Winnicott", "and", "others", ",", "are", "two", "contrasting", "treatment", "techniques", "in", "psychoanalysis", ".", "The", "authors", "believe", "that", "each", "of", "these", "two", "techniques", "presupposes", "specific", "philosophical", "basic", "assumptions", "about", "the", "nature", "of", "human", "beings", ".", "The", "position", "of", "Freud", "is", "that", "of", "the", "basically", "traumatic", "character", "of", "human", "experience", ".", "The", "contra", "-", "position", "of", "the", "object", "relation", "psychologists", "stipulates", "the", "priority", "of", "love", "in", "human", "experience", ".", "These", "assumptions", "seem", "to", "be", "more", "latent", "than", "overt", "guidelines", "of", "therapeutical", "techniques", "and", "therefore", "their", "reconstruction", "and", "reformulation", "have", "important", "implications", "for", "psychoanalytical", "therapy", "." ]	[ "umlsterm" ]
Ile646Lys is a GENE-N, gp41 coiled - coil domain is a GENE-N	23522564_task0	Sentence: Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N	[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]	Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation.	[ "Addition", "of", "artificial", "salt", "bridge", "by", "Ile646Lys", "mutation", "in", "gp41", "coiled", "-", "coil", "domain", "regulates", "6-helical", "bundle", "formation", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Ile646Lys is a GENE-N, gp41 coiled - coil domain is a GENE-N	23522564_task1	Sentence: Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation. Instructions: please typing these entity words according to sentence: Ile646Lys, gp41 coiled - coil domain Options: GENE-N	[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]	Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation.	[ "Addition", "of", "artificial", "salt", "bridge", "by", "Ile646Lys", "mutation", "in", "gp41", "coiled", "-", "coil", "domain", "regulates", "6-helical", "bundle", "formation", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
Ile646Lys, gp41 coiled - coil domain	23522564_task2	Sentence: Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]	Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation.	[ "Addition", "of", "artificial", "salt", "bridge", "by", "Ile646Lys", "mutation", "in", "gp41", "coiled", "-", "coil", "domain", "regulates", "6-helical", "bundle", "formation", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
methanol is a CHEMICAL, aflatoxin is a CHEMICAL, aflatoxin B(1 ) is a CHEMICAL, malondialdehyde is a CHEMICAL, superoxide dismutase is a GENE-N, glutathione is a CHEMICAL, glutathione peroxidase is a GENE-N, aflatoxin is a CHEMICAL, N - methyl - N'-nitro - N - nitrosoguanidine is a CHEMICAL, acridin is a CHEMICAL, aflatoxin is a CHEMICAL	19853_task0	Sentence: Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-CHEMICAL", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O" ]	Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin.	[ "Antigenotoxic", "potencies", "of", "a", "lichen", "species", ",", "Evernia", "prunastri", ".", "\n", "In", "this", "article", ",", "the", "genotoxic", "and", "antigenotoxic", "effects", "of", "methanol", "extract", "of", "Evernia", "prunastri", "(", "Huds", ".", ")", "Willd", ".", "(", "MEP", ")", "were", "studied", "using", "WP2", ",", "Ames", "(", "TA1535", "and", "TA1537", ")", "and", "sister", "chromatid", "exchange", "(", "SCE", ")", "test", "systems", ".", "The", "results", "obtained", "from", "bacterial", "test", "systems", "demonstrated", "that", "MEP", "has", "strong", "antimutagenic", "potencies", "on", "TA1537", "and", "WP2", "strains", ".", "The", "highest", "inhibition", "rates", "for", "MEP", "on", "TA1537", "and", "WP2", "strains", "were", "37.70", "%", "and", "69.70", "%", ",", "respectively", ".", "According", "to", "the", "SCE", "test", "system", ",", "MEP", "reduced", "the", "genotoxic", "effects", "of", "aflatoxin", ".", "In", "order", "to", "clarify", "the", "mechanism", "underlying", "the", "antigenotoxic", "effects", "of", "MEP", ",", "the", "antioxidants", "were", "determined", ".", "Cotreatments", "of", "5", ",", "10", "and", "20", "µg", "/", "mL", "concentrations", "of", "MEP", "with", "aflatoxin", "B(1", ")", "decreased", "the", "frequencies", "of", "SCE", "and", "the", "malondialdehyde", "level", "and", "increased", "amount", "of", "superoxide", "dismutase", ",", "glutathione", "and", "glutathione", "peroxidase", "which", "were", "decreased", "by", "aflatoxin", ".", "The", "data", "obtained", "from", "this", "work", "have", "clearly", "shown", "that", "MEP", "has", "significant", "antigenotoxic", "effects", "which", "are", "thought", "to", "be", "partly", "due", "to", "the", "antioxidant", "activities", "and", "antioxidant", "inducing", "capability", "of", "MEP", ".", "This", "is", "the", "first", "report", "indicating", "the", "antigenotoxic", "activities", "of", "MEP", "against", "several", "mutagen", "agents", "such", "as", "N", "-", "methyl", "-", "N'-nitro", "-", "N", "-", "nitrosoguanidine", ",", "acridin", "and", "aflatoxin", "." ]	[ "CHEMICAL", "GENE-N" ]
methanol is a CHEMICAL, aflatoxin is a CHEMICAL, aflatoxin B(1 ) is a CHEMICAL, malondialdehyde is a CHEMICAL, superoxide dismutase is a GENE-N, glutathione is a CHEMICAL, glutathione peroxidase is a GENE-N, aflatoxin is a CHEMICAL, N - methyl - N'-nitro - N - nitrosoguanidine is a CHEMICAL, acridin is a CHEMICAL, aflatoxin is a CHEMICAL	19853_task1	Sentence: Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin. Instructions: please typing these entity words according to sentence: methanol, aflatoxin, aflatoxin B(1 ), malondialdehyde, superoxide dismutase, glutathione, glutathione peroxidase, aflatoxin, N - methyl - N'-nitro - N - nitrosoguanidine, acridin, aflatoxin Options: GENE-N, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-CHEMICAL", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O" ]	Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin.	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methanol, aflatoxin, aflatoxin B(1 ), malondialdehyde, superoxide dismutase, glutathione, glutathione peroxidase, aflatoxin, N - methyl - N'-nitro - N - nitrosoguanidine, acridin, aflatoxin	19853_task2	Sentence: Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "B-CHEMICAL", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O" ]	Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin.	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Doppelblindstudie is an umlsterm, Patienten is an umlsterm, Sufentanil is an umlsterm, Alfentanil is an umlsterm, Analgesie is an umlsterm, Stosswellenlithotripsie is an umlsterm, Sufentanil is an umlsterm, Alfentanil is an umlsterm, Blutdruckverhalten is an umlsterm, Kohlendioxidpartialdruck is an umlsterm, Sauerstoffsaettigung is an umlsterm, Spontanatmung is an umlsterm, Behandlung is an umlsterm, Eigenbeurteilung is an umlsterm, Muedigkeit is an umlsterm, Schmerz is an umlsterm, Patienten is an umlsterm, Beurteilung is an umlsterm, Schmerzen is an umlsterm, Gesamtbeurteilung is an umlsterm, Patienten is an umlsterm, Opioide is an umlsterm, Atemdepression is an umlsterm, Alfentanil is an umlsterm, Sufentanil is an umlsterm, Analgesiequalitaet is an umlsterm, Patienten is an umlsterm, Vigilanzbeurteilung is an umlsterm, Patienten is an umlsterm, Behandlungsende is an umlsterm, Sufentanil is an umlsterm, Sufentanil is an umlsterm, Beurteilung is an umlsterm, Patienten is an umlsterm, Sufentanil is an umlsterm, Analgesie is an umlsterm	DerAnaesthesist.60450330.ger.abstr_task0	Sentence: In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen .	[ "In", "der", "prospektiven", "randomisierten", "Doppelblindstudie", "wurden", "62", "Patienten", "der", "ASA", "-", "Klassen", "I", "-", "II", "in", "zwei", "Gruppen", "verteilt", ".", "Gruppe", "I", "erhielt", "Sufentanil", ",", "Gruppe", "II", "Alfentanil", "zur", "intravenoesen", "Analgesie", "bei", "extrakorporaler", "Stosswellenlithotripsie", "(", "ESWL", ")", ".", "Die", "Dosierung", "fuer", "Sufentanil", "betrug", "durchschnittlich", "0,11", "mg", ",", "fuer", "Alfentanil", "4,2", "mg", ".", "Untersucht", "wurden", "Blutdruckverhalten", ",", "transkutaner", "Kohlendioxidpartialdruck", "(", "PtcCO2", ")", "und", "Sauerstoffsaettigung", "mittels", "Pulsoximetrie", "(", "spO2", ")", "bei", "Spontanatmung", "mit", "O2-Maske", "(", "6", "l", "/", "min", ")", "vor", "und", "waehrend", "der", "Behandlung", "und", "waehrend", "2", "h", "postoperativer", "Aufwachraumzeit", ".", "Gleichzeitig", "erfolgten", "eine", "Eigenbeurteilung", "von", "Muedigkeit", "und", "Schmerz", "anhand", "der", "visuellen", "Analogskala", "(", "VAS", ")", "durch", "den", "Patienten", "sowie", "eine", "Beurteilung", "der", "Vigilanz", "und", "der", "Schmerzen", "durch", "den", "Anaesthesisten", "(", "VAS", ")", ".", "Nach", "Abschluss", "der", "Ueberwachungsphase", "erfolgte", "eine", "Gesamtbeurteilung", "durch", "den", "Patienten", ",", "den", "Anaesthesisten", "und", "den", "Behandler", ".", "Beide", "Opioide", "boten", "stabile", "kardiozirkulatorische", "Verhaeltnisse", ".", "Die", "opioidinduzierte", "Atemdepression", "war", "sowohl", "unter", "Alfentanil", "als", "auch", "unter", "Sufentanil", "gleich", "ausgepraegt", ".", "Die", "Analgesiequalitaet", "wurde", "sowohl", "vom", "Patienten", "als", "auch", "vom", "Anaesthesisten", "gleich", "gut", "beurteilt", ".", "Waehrend", "die", "Vigilanzbeurteilung", "durch", "den", "Anaesthesisten", "keine", "Unterschiede", "zeigte", ",", "fuehlten", "sich", "die", "Patienten", "bis", "2", "h", "nach", "Behandlungsende", "signifikant", "mueder", "unter", "Sufentanil", ".", "Opioidtypische", "Nebenwirkungen", "traten", "unter", "Sufentanil", "haeufiger", "auf", "24", "vs", ".", "11", ")", ".", "(", "Diese", "fuehrten", "zu", "einer", "insgesamt", "schlechteren", "Beurteilung", "des", "Narkoseverfahrens", "durch", "die", "Patienten", "und", "den", "Anaesthesisten", ".", "Dies", "laesst", "Sufentanil", "fuer", "die", "intravenoese", "Analgesie", "weniger", "geeignet", "erscheinen", "." ]	[ "umlsterm" ]
Doppelblindstudie is an umlsterm, Patienten is an umlsterm, Sufentanil is an umlsterm, Alfentanil is an umlsterm, Analgesie is an umlsterm, Stosswellenlithotripsie is an umlsterm, Sufentanil is an umlsterm, Alfentanil is an umlsterm, Blutdruckverhalten is an umlsterm, Kohlendioxidpartialdruck is an umlsterm, Sauerstoffsaettigung is an umlsterm, Spontanatmung is an umlsterm, Behandlung is an umlsterm, Eigenbeurteilung is an umlsterm, Muedigkeit is an umlsterm, Schmerz is an umlsterm, Patienten is an umlsterm, Beurteilung is an umlsterm, Schmerzen is an umlsterm, Gesamtbeurteilung is an umlsterm, Patienten is an umlsterm, Opioide is an umlsterm, Atemdepression is an umlsterm, Alfentanil is an umlsterm, Sufentanil is an umlsterm, Analgesiequalitaet is an umlsterm, Patienten is an umlsterm, Vigilanzbeurteilung is an umlsterm, Patienten is an umlsterm, Behandlungsende is an umlsterm, Sufentanil is an umlsterm, Sufentanil is an umlsterm, Beurteilung is an umlsterm, Patienten is an umlsterm, Sufentanil is an umlsterm, Analgesie is an umlsterm	DerAnaesthesist.60450330.ger.abstr_task1	Sentence: In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen . 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Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen .	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Doppelblindstudie, Patienten, Sufentanil, Alfentanil, Analgesie, Stosswellenlithotripsie, Sufentanil, Alfentanil, Blutdruckverhalten, Kohlendioxidpartialdruck, Sauerstoffsaettigung, Spontanatmung, Behandlung, Eigenbeurteilung, Muedigkeit, Schmerz, Patienten, Beurteilung, Schmerzen, Gesamtbeurteilung, Patienten, Opioide, Atemdepression, Alfentanil, Sufentanil, Analgesiequalitaet, Patienten, Vigilanzbeurteilung, Patienten, Behandlungsende, Sufentanil, Sufentanil, Beurteilung, Patienten, Sufentanil, Analgesie	DerAnaesthesist.60450330.ger.abstr_task2	Sentence: In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen .	[ "In", "der", "prospektiven", "randomisierten", "Doppelblindstudie", "wurden", "62", "Patienten", "der", "ASA", "-", "Klassen", "I", "-", "II", "in", "zwei", "Gruppen", "verteilt", ".", "Gruppe", "I", "erhielt", "Sufentanil", ",", "Gruppe", "II", "Alfentanil", "zur", "intravenoesen", "Analgesie", "bei", "extrakorporaler", "Stosswellenlithotripsie", "(", "ESWL", ")", ".", "Die", "Dosierung", "fuer", "Sufentanil", "betrug", "durchschnittlich", "0,11", "mg", ",", "fuer", "Alfentanil", "4,2", "mg", ".", "Untersucht", "wurden", "Blutdruckverhalten", ",", "transkutaner", "Kohlendioxidpartialdruck", "(", "PtcCO2", ")", "und", "Sauerstoffsaettigung", "mittels", "Pulsoximetrie", "(", "spO2", ")", "bei", "Spontanatmung", "mit", "O2-Maske", "(", "6", "l", "/", "min", ")", "vor", "und", "waehrend", "der", "Behandlung", "und", "waehrend", "2", "h", "postoperativer", "Aufwachraumzeit", ".", "Gleichzeitig", "erfolgten", "eine", "Eigenbeurteilung", "von", "Muedigkeit", "und", "Schmerz", "anhand", "der", "visuellen", "Analogskala", "(", "VAS", ")", "durch", "den", "Patienten", "sowie", "eine", "Beurteilung", "der", "Vigilanz", "und", "der", "Schmerzen", "durch", "den", "Anaesthesisten", "(", "VAS", ")", ".", "Nach", "Abschluss", "der", "Ueberwachungsphase", "erfolgte", "eine", "Gesamtbeurteilung", "durch", "den", "Patienten", ",", "den", "Anaesthesisten", "und", "den", "Behandler", ".", "Beide", "Opioide", "boten", "stabile", "kardiozirkulatorische", "Verhaeltnisse", ".", "Die", "opioidinduzierte", "Atemdepression", "war", "sowohl", "unter", "Alfentanil", "als", "auch", "unter", "Sufentanil", "gleich", "ausgepraegt", ".", "Die", "Analgesiequalitaet", "wurde", "sowohl", "vom", "Patienten", "als", "auch", "vom", "Anaesthesisten", "gleich", "gut", "beurteilt", ".", "Waehrend", "die", "Vigilanzbeurteilung", "durch", "den", "Anaesthesisten", "keine", "Unterschiede", "zeigte", ",", "fuehlten", "sich", "die", "Patienten", "bis", "2", "h", "nach", "Behandlungsende", "signifikant", "mueder", "unter", "Sufentanil", ".", "Opioidtypische", "Nebenwirkungen", "traten", "unter", "Sufentanil", "haeufiger", "auf", "24", "vs", ".", "11", ")", ".", "(", "Diese", "fuehrten", "zu", "einer", "insgesamt", "schlechteren", "Beurteilung", "des", "Narkoseverfahrens", "durch", "die", "Patienten", "und", "den", "Anaesthesisten", ".", "Dies", "laesst", "Sufentanil", "fuer", "die", "intravenoese", "Analgesie", "weniger", "geeignet", "erscheinen", "." ]	[ "umlsterm" ]
Spi - B is a Protein, Spi - B is a Protein, Spi-1 is a Protein, PU.1 is a Protein, Ets domain is a Entity, DNA is a Entity, Spi - B is a Protein, DNA sequences is a Entity, 5'-GGAA-3 ' is a Entity, Spi - B is a Protein, Spi - B is a Protein, deltaSpi - B is a Protein, Ets domain is a Entity, deltaspi - B is a Protein, spi - B is a Protein, DeltaSpi - B is a Protein, DNA is a Entity, delta Spi - B is a Protein, Spi - B is a Protein, Spi - B is a Protein	212_task0	Sentence: An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "B-Entity", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Entity", "I-Entity", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O" ]	An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity.	[ "An", "alternatively", "spliced", "isoform", "of", "the", "Spi", "-", "B", "transcription", "factor", ".", "\n", "Spi", "-", "B", "is", "an", "Ets", "transcription", "factor", "related", "to", "the", "oncoprotein", "Spi-1", "/", "PU.1", "and", "highly", "expressed", "in", "B", "lymphoid", "cells", ".", "The", "Ets", "proteins", "share", "a", "conserved", "Ets", "domain", "that", "mediates", "specific", "DNA", "binding", ".", "Spi", "-", "B", "binds", "DNA", "sequences", "containing", "a", "core", "5'-GGAA-3", "'", "and", "activates", "transcription", "through", "this", "motif", ".", "Up", "to", "date", ",", "the", "biological", "function", "of", "Spi", "-", "B", "remains", "unknown", ".", "Here", ",", "we", "describe", "the", "characterization", "of", "an", "alternatively", "spliced", "variant", "of", "Spi", "-", "B", ",", "named", "deltaSpi", "-", "B", ",", "which", "has", "lost", "the", "Ets", "domain", ".", "In", "B", "lymphoid", "cells", ",", "deltaspi", "-", "B", "and", "spi", "-", "B", "mRNAs", "were", "present", "simultaneously", "in", "a", "ratio", "of", "around", "10", "%", ".", "DeltaSpi", "-", "B", "product", "was", "not", "able", "to", "bind", "DNA", "and", "was", "recovered", "in", "cytoplasmic", "cellular", "extracts", ".", "We", "raise", "the", "hypothesis", "that", "delta", "Spi", "-", "B", "might", "affect", "Spi", "-", "B", "function", "by", "recruiting", "factors", "involved", "in", "Spi", "-", "B", "activity", ".", "\n" ]	[ "Entity", "Protein" ]
Spi - B is a Protein, Spi - B is a Protein, Spi-1 is a Protein, PU.1 is a Protein, Ets domain is a Entity, DNA is a Entity, Spi - B is a Protein, DNA sequences is a Entity, 5'-GGAA-3 ' is a Entity, Spi - B is a Protein, Spi - B is a Protein, deltaSpi - B is a Protein, Ets domain is a Entity, deltaspi - B is a Protein, spi - B is a Protein, DeltaSpi - B is a Protein, DNA is a Entity, delta Spi - B is a Protein, Spi - B is a Protein, Spi - B is a Protein	212_task1	Sentence: An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity. Instructions: please typing these entity words according to sentence: Spi - B, Spi - B, Spi-1, PU.1, Ets domain, DNA, Spi - B, DNA sequences, 5'-GGAA-3 ', Spi - B, Spi - B, deltaSpi - B, Ets domain, deltaspi - B, spi - B, DeltaSpi - B, DNA, delta Spi - B, Spi - B, Spi - B Options: Entity, Protein	[ "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "B-Entity", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Entity", "I-Entity", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O" ]	An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity.	[ "An", "alternatively", "spliced", "isoform", "of", "the", "Spi", "-", "B", "transcription", "factor", ".", "\n", "Spi", "-", "B", "is", "an", "Ets", "transcription", "factor", "related", "to", "the", "oncoprotein", "Spi-1", "/", "PU.1", "and", "highly", "expressed", "in", "B", "lymphoid", "cells", ".", "The", "Ets", "proteins", "share", "a", "conserved", "Ets", "domain", "that", "mediates", "specific", "DNA", "binding", ".", "Spi", "-", "B", "binds", "DNA", "sequences", "containing", "a", "core", "5'-GGAA-3", "'", "and", "activates", "transcription", "through", "this", "motif", ".", "Up", "to", "date", ",", "the", "biological", "function", "of", "Spi", "-", "B", "remains", "unknown", ".", "Here", ",", "we", "describe", "the", "characterization", "of", "an", "alternatively", "spliced", "variant", "of", "Spi", "-", "B", ",", "named", "deltaSpi", "-", "B", ",", "which", "has", "lost", "the", "Ets", "domain", ".", "In", "B", "lymphoid", "cells", ",", "deltaspi", "-", "B", "and", "spi", "-", "B", "mRNAs", "were", "present", "simultaneously", "in", "a", "ratio", "of", "around", "10", "%", ".", "DeltaSpi", "-", "B", "product", "was", "not", "able", "to", "bind", "DNA", "and", "was", "recovered", "in", "cytoplasmic", "cellular", "extracts", ".", "We", "raise", "the", "hypothesis", "that", "delta", "Spi", "-", "B", "might", "affect", "Spi", "-", "B", "function", "by", "recruiting", "factors", "involved", "in", "Spi", "-", "B", "activity", ".", "\n" ]	[ "Entity", "Protein" ]
Spi - B, Spi - B, Spi-1, PU.1, Ets domain, DNA, Spi - B, DNA sequences, 5'-GGAA-3 ', Spi - B, Spi - B, deltaSpi - B, Ets domain, deltaspi - B, spi - B, DeltaSpi - B, DNA, delta Spi - B, Spi - B, Spi - B	212_task2	Sentence: An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "B-Entity", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Entity", "I-Entity", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O" ]	An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity.	[ "An", "alternatively", "spliced", "isoform", "of", "the", "Spi", "-", "B", "transcription", "factor", ".", "\n", "Spi", "-", "B", "is", "an", "Ets", "transcription", "factor", "related", "to", "the", "oncoprotein", "Spi-1", "/", "PU.1", "and", "highly", "expressed", "in", "B", "lymphoid", "cells", ".", "The", "Ets", "proteins", "share", "a", "conserved", "Ets", "domain", "that", "mediates", "specific", "DNA", "binding", ".", "Spi", "-", "B", "binds", "DNA", "sequences", "containing", "a", "core", "5'-GGAA-3", "'", "and", "activates", "transcription", "through", "this", "motif", ".", "Up", "to", "date", ",", "the", "biological", "function", "of", "Spi", "-", "B", "remains", "unknown", ".", "Here", ",", "we", "describe", "the", "characterization", "of", "an", "alternatively", "spliced", "variant", "of", "Spi", "-", "B", ",", "named", "deltaSpi", "-", "B", ",", "which", "has", "lost", "the", "Ets", "domain", ".", "In", "B", "lymphoid", "cells", ",", "deltaspi", "-", "B", "and", "spi", "-", "B", "mRNAs", "were", "present", "simultaneously", "in", "a", "ratio", "of", "around", "10", "%", ".", "DeltaSpi", "-", "B", "product", "was", "not", "able", "to", "bind", "DNA", "and", "was", "recovered", "in", "cytoplasmic", "cellular", "extracts", ".", "We", "raise", "the", "hypothesis", "that", "delta", "Spi", "-", "B", "might", "affect", "Spi", "-", "B", "function", "by", "recruiting", "factors", "involved", "in", "Spi", "-", "B", "activity", ".", "\n" ]	[ "Entity", "Protein" ]
TDP-43 is a protein, UG ( or TG ) single - stranded dinucleotide is a DNA	1.0alpha7.train.483_task0	Sentence: Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA, protein	[ "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats.	[ " ", "Interestingly", ",", " ", "TDP-43", "can", "bind", "a", "minimum", "number", "of", "six", " ", "UG", "(", "or", "TG", ")", "single", "-", "stranded", "dinucleotide", "stretches", ",", "and", "binding", "affinity", "increases", "with", "the", "number", "of", "repeats", ".", " " ]	[ "DNA", "protein" ]
TDP-43 is a protein, UG ( or TG ) single - stranded dinucleotide is a DNA	1.0alpha7.train.483_task1	Sentence: Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats. Instructions: please typing these entity words according to sentence: TDP-43, UG ( or TG ) single - stranded dinucleotide Options: DNA, protein	[ "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats.	[ " ", "Interestingly", ",", " ", "TDP-43", "can", "bind", "a", "minimum", "number", "of", "six", " ", "UG", "(", "or", "TG", ")", "single", "-", "stranded", "dinucleotide", "stretches", ",", "and", "binding", "affinity", "increases", "with", "the", "number", "of", "repeats", ".", " " ]	[ "DNA", "protein" ]
TDP-43, UG ( or TG ) single - stranded dinucleotide	1.0alpha7.train.483_task2	Sentence: Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats.	[ " ", "Interestingly", ",", " ", "TDP-43", "can", "bind", "a", "minimum", "number", "of", "six", " ", "UG", "(", "or", "TG", ")", "single", "-", "stranded", "dinucleotide", "stretches", ",", "and", "binding", "affinity", "increases", "with", "the", "number", "of", "repeats", ".", " " ]	[ "DNA", "protein" ]
Protein kinase C is a protein_molecule, p21ras is a DNA_domain_or_region, activated T cells is a cell_type	6933_task0	Sentence: Protein kinase C is not a downstream effector of p21ras in activated T cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, DNA_domain_or_region, protein_molecule	[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O" ]	Protein kinase C is not a downstream effector of p21ras in activated T cells.	[ "Protein", "kinase", "C", "is", "not", "a", "downstream", "effector", "of", "p21ras", "in", "activated", "T", "cells", "." ]	[ "other_name", "DNA_domain_or_region", "cell_line", "cell_type", "protein_molecule", "other_organic_compound", "protein_family_or_group", "atom" ]
Protein kinase C is a protein_molecule, p21ras is a DNA_domain_or_region, activated T cells is a cell_type	6933_task1	Sentence: Protein kinase C is not a downstream effector of p21ras in activated T cells. Instructions: please typing these entity words according to sentence: Protein kinase C, p21ras, activated T cells Options: cell_type, DNA_domain_or_region, protein_molecule	[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O" ]	Protein kinase C is not a downstream effector of p21ras in activated T cells.	[ "Protein", "kinase", "C", "is", "not", "a", "downstream", "effector", "of", "p21ras", "in", "activated", "T", "cells", "." ]	[ "other_name", "DNA_domain_or_region", "cell_line", "cell_type", "protein_molecule", "other_organic_compound", "protein_family_or_group", "atom" ]
Protein kinase C, p21ras, activated T cells	6933_task2	Sentence: Protein kinase C is not a downstream effector of p21ras in activated T cells. Instructions: please extract entity words from the input sentence	[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O" ]	Protein kinase C is not a downstream effector of p21ras in activated T cells.	[ "Protein", "kinase", "C", "is", "not", "a", "downstream", "effector", "of", "p21ras", "in", "activated", "T", "cells", "." ]	[ "other_name", "DNA_domain_or_region", "cell_line", "cell_type", "protein_molecule", "other_organic_compound", "protein_family_or_group", "atom" ]
thrombogenic factors is a Gene_or_gene_product, Hemostatic factors is a Gene_or_gene_product, thrombotic plugs is a Pathological_formation, vascular is a Multi-tissue_structure, hemostatic factors is a Gene_or_gene_product, intimal is a Tissue, lipid - rich plaque is a Pathological_formation, lesions is a Pathological_formation, intimal is a Tissue, Platelets is a Cell, thrombus is a Pathological_formation, intimal is a Tissue, platelet is a Cell, thrombus is a Pathological_formation, Tissue factor is a Gene_or_gene_product, TF is a Gene_or_gene_product, blood is a Organism_substance, atherosclerotic lesions is a Pathological_formation, humans is a Organism, thrombin is a Gene_or_gene_product, fibrin is a Gene_or_gene_product, TF is a Gene_or_gene_product, TF is a Gene_or_gene_product, cell is a Cell, TF is a Gene_or_gene_product, protease - activated receptor 2 is a Gene_or_gene_product	86_task0	Sentence: Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Tissue, Gene_or_gene_product, Organism_substance, Pathological_formation, Organism, Multi-tissue_structure, Cell	[ "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "B-Organism", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis.	[ "Role", "of", "thrombogenic", "factors", "in", "the", "development", "of", "atherosclerosis", ".", "\n", "Hemostatic", "factors", "play", "a", "crucial", "role", "in", "generating", "thrombotic", "plugs", "at", "sites", "of", "vascular", "damage", "(", "atherothrombosis", ")", ".", "However", ",", "whether", "hemostatic", "factors", "contribute", "directly", "or", "indirectly", "to", "the", "pathogenesis", "of", "atherosclerosis", "remains", "uncertain", ".", "Autopsy", "studies", "have", "revealed", "that", "intimal", "thickening", "represents", "the", "first", "stage", "of", "atherosclerosis", "and", "that", "lipid", "-", "rich", "plaque", "arises", "from", "such", "lesions", ".", "Several", "factors", "contribute", "to", "the", "start", "of", "intimal", "thickening", ".", "Platelets", "release", "several", "growth", "factors", "and", "bioactive", "agents", "that", "play", "a", "central", "role", "in", "development", "of", "not", "only", "thrombus", "but", "also", "of", "intimal", "thickening", ".", "We", "have", "been", "investigating", "which", "coagulation", "factors", "simultaneously", ",", "or", "subsequently", "with", "platelet", "aggregation", ",", "participate", "in", "thrombus", "formation", ".", "Tissue", "factor", "(", "TF", ")", "is", "an", "essential", "initiator", "of", "blood", "coagulation", "that", "is", "expressed", "in", "various", "stages", "of", "atherosclerotic", "lesions", "in", "humans", "and", "other", "animals", ".", "Factors", "including", "thrombin", "and", "fibrin", ",", "which", "are", "downstream", "of", "the", "coagulation", "cascade", "activated", "by", "TF", ",", "also", "contribute", "to", "atherosclerosis", ".", "TF", "is", "involved", "in", "cell", "migration", ",", "embryogenesis", "and", "angiogenesis", ".", "Thus", "TF", ",", "in", "addition", "to", "factors", "downstream", "of", "the", "coagulation", "cascade", "and", "the", "protease", "-", "activated", "receptor", "2", "activation", "system", ",", "would", "be", "a", "multifactorial", "regulator", "of", "atherogenesis", ".", "\n" ]	[ "Gene_or_gene_product", "Pathological_formation", "Cell", "Multi-tissue_structure", "Tissue", "Organism", "Organism_substance" ]
thrombogenic factors is a Gene_or_gene_product, Hemostatic factors is a Gene_or_gene_product, thrombotic plugs is a Pathological_formation, vascular is a Multi-tissue_structure, hemostatic factors is a Gene_or_gene_product, intimal is a Tissue, lipid - rich plaque is a Pathological_formation, lesions is a Pathological_formation, intimal is a Tissue, Platelets is a Cell, thrombus is a Pathological_formation, intimal is a Tissue, platelet is a Cell, thrombus is a Pathological_formation, Tissue factor is a Gene_or_gene_product, TF is a Gene_or_gene_product, blood is a Organism_substance, atherosclerotic lesions is a Pathological_formation, humans is a Organism, thrombin is a Gene_or_gene_product, fibrin is a Gene_or_gene_product, TF is a Gene_or_gene_product, TF is a Gene_or_gene_product, cell is a Cell, TF is a Gene_or_gene_product, protease - activated receptor 2 is a Gene_or_gene_product	86_task1	Sentence: Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis. Instructions: please typing these entity words according to sentence: thrombogenic factors, Hemostatic factors, thrombotic plugs, vascular, hemostatic factors, intimal, lipid - rich plaque, lesions, intimal, Platelets, thrombus, intimal, platelet, thrombus, Tissue factor, TF, blood, atherosclerotic lesions, humans, thrombin, fibrin, TF, TF, cell, TF, protease - activated receptor 2 Options: Tissue, Gene_or_gene_product, Organism_substance, Pathological_formation, Organism, Multi-tissue_structure, Cell	[ "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "B-Organism", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis.	[ "Role", "of", "thrombogenic", "factors", "in", "the", "development", "of", "atherosclerosis", ".", "\n", "Hemostatic", "factors", "play", "a", "crucial", "role", "in", "generating", "thrombotic", "plugs", "at", "sites", "of", "vascular", "damage", "(", "atherothrombosis", ")", ".", "However", ",", "whether", "hemostatic", "factors", "contribute", "directly", "or", "indirectly", "to", "the", "pathogenesis", "of", "atherosclerosis", "remains", "uncertain", ".", "Autopsy", "studies", "have", "revealed", "that", "intimal", "thickening", "represents", "the", "first", "stage", "of", "atherosclerosis", "and", "that", "lipid", "-", "rich", "plaque", "arises", "from", "such", "lesions", ".", "Several", "factors", "contribute", "to", "the", "start", "of", "intimal", "thickening", ".", "Platelets", "release", "several", "growth", "factors", "and", "bioactive", "agents", "that", "play", "a", "central", "role", "in", "development", "of", "not", "only", "thrombus", "but", "also", "of", "intimal", "thickening", ".", "We", "have", "been", "investigating", "which", "coagulation", "factors", "simultaneously", ",", "or", "subsequently", "with", "platelet", "aggregation", ",", "participate", "in", "thrombus", "formation", ".", "Tissue", "factor", "(", "TF", ")", "is", "an", "essential", "initiator", "of", "blood", "coagulation", "that", "is", "expressed", "in", "various", "stages", "of", "atherosclerotic", "lesions", "in", "humans", "and", "other", "animals", ".", "Factors", "including", "thrombin", "and", "fibrin", ",", "which", "are", "downstream", "of", "the", "coagulation", "cascade", "activated", "by", "TF", ",", "also", "contribute", "to", "atherosclerosis", ".", "TF", "is", "involved", "in", "cell", "migration", ",", "embryogenesis", "and", "angiogenesis", ".", "Thus", "TF", ",", "in", "addition", "to", "factors", "downstream", "of", "the", "coagulation", "cascade", "and", "the", "protease", "-", "activated", "receptor", "2", "activation", "system", ",", "would", "be", "a", "multifactorial", "regulator", "of", "atherogenesis", ".", "\n" ]	[ "Gene_or_gene_product", "Pathological_formation", "Cell", "Multi-tissue_structure", "Tissue", "Organism", "Organism_substance" ]
thrombogenic factors, Hemostatic factors, thrombotic plugs, vascular, hemostatic factors, intimal, lipid - rich plaque, lesions, intimal, Platelets, thrombus, intimal, platelet, thrombus, Tissue factor, TF, blood, atherosclerotic lesions, humans, thrombin, fibrin, TF, TF, cell, TF, protease - activated receptor 2	86_task2	Sentence: Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "B-Organism", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis.	[ "Role", "of", "thrombogenic", "factors", "in", "the", "development", "of", "atherosclerosis", ".", "\n", "Hemostatic", "factors", "play", "a", "crucial", "role", "in", "generating", "thrombotic", "plugs", "at", "sites", "of", "vascular", "damage", "(", "atherothrombosis", ")", ".", "However", ",", "whether", "hemostatic", "factors", "contribute", "directly", "or", "indirectly", "to", "the", "pathogenesis", "of", "atherosclerosis", "remains", "uncertain", ".", "Autopsy", "studies", "have", "revealed", "that", "intimal", "thickening", "represents", "the", "first", "stage", "of", "atherosclerosis", "and", "that", "lipid", "-", "rich", "plaque", "arises", "from", "such", "lesions", ".", "Several", "factors", "contribute", "to", "the", "start", "of", "intimal", "thickening", ".", "Platelets", "release", "several", "growth", "factors", "and", "bioactive", "agents", "that", "play", "a", "central", "role", "in", "development", "of", "not", "only", "thrombus", "but", "also", "of", "intimal", "thickening", ".", "We", "have", "been", "investigating", "which", "coagulation", "factors", "simultaneously", ",", "or", "subsequently", "with", "platelet", "aggregation", ",", "participate", "in", "thrombus", "formation", ".", "Tissue", "factor", "(", "TF", ")", "is", "an", "essential", "initiator", "of", "blood", "coagulation", "that", "is", "expressed", "in", "various", "stages", "of", "atherosclerotic", "lesions", "in", "humans", "and", "other", "animals", ".", "Factors", "including", "thrombin", "and", "fibrin", ",", "which", "are", "downstream", "of", "the", "coagulation", "cascade", "activated", "by", "TF", ",", "also", "contribute", "to", "atherosclerosis", ".", "TF", "is", "involved", "in", "cell", "migration", ",", "embryogenesis", "and", "angiogenesis", ".", "Thus", "TF", ",", "in", "addition", "to", "factors", "downstream", "of", "the", "coagulation", "cascade", "and", "the", "protease", "-", "activated", "receptor", "2", "activation", "system", ",", "would", "be", "a", "multifactorial", "regulator", "of", "atherogenesis", ".", "\n" ]	[ "Gene_or_gene_product", "Pathological_formation", "Cell", "Multi-tissue_structure", "Tissue", "Organism", "Organism_substance" ]
patients is an umlsterm, phototoxic contact dermatitis is an umlsterm, albus is an umlsterm, gas is an umlsterm, plant is an umlsterm, family is an umlsterm, phototoxic contact dermatitis is an umlsterm, albus is an umlsterm, furocoumarins is an umlsterm, 5-methoxypsoralen is an umlsterm, bergapten is an umlsterm, 8-methoxypsoralen is an umlsterm, alkaloid is an umlsterm, gas is an umlsterm, plant is an umlsterm, differential diagnosis is an umlsterm, phototoxic contact dermatitis is an umlsterm	DerHautarzt.60470708.eng.abstr_task0	Sentence: We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis .	[ "We", "report", "two", "patients", "with", "bullous", "phototoxic", "contact", "dermatitis", "caused", "by", "Dictamnus", "albus", "L.", "(", "gas", "plant", ")", "which", "belongs", "to", "the", "Rutaceae", "family", ".", "In", "both", "cases", "long", "lasting", "postinflammatory", "hyperpigmentations", "were", "observed", "as", "a", "result", "of", "the", "phototoxic", "contact", "dermatitis", ".", "The", "phototoxic", "components", "of", "Dictamnus", "albus", "L.", "are", "the", "furocoumarins", "5-methoxypsoralen", "(", "bergapten", ")", "and", "8-methoxypsoralen", ",", "and", "the", "alkaloid", "dictamnin", "whose", "phototoxic", "properties", "were", "recently", "discovered", ".", "Even", "though", "reactions", "to", "the", "gas", "plant", "have", "been", "infrequently", "reported", ",", "it", "is", "becoming", "more", "popular", "with", "gardenus", "and", "should", "be", "considered", "in", "the", "differential", "diagnosis", "of", "phototoxic", "contact", "dermatitis", "." ]	[ "umlsterm" ]
patients is an umlsterm, phototoxic contact dermatitis is an umlsterm, albus is an umlsterm, gas is an umlsterm, plant is an umlsterm, family is an umlsterm, phototoxic contact dermatitis is an umlsterm, albus is an umlsterm, furocoumarins is an umlsterm, 5-methoxypsoralen is an umlsterm, bergapten is an umlsterm, 8-methoxypsoralen is an umlsterm, alkaloid is an umlsterm, gas is an umlsterm, plant is an umlsterm, differential diagnosis is an umlsterm, phototoxic contact dermatitis is an umlsterm	DerHautarzt.60470708.eng.abstr_task1	Sentence: We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis . Instructions: please typing these entity words according to sentence: patients, phototoxic contact dermatitis, albus, gas, plant, family, phototoxic contact dermatitis, albus, furocoumarins, 5-methoxypsoralen, bergapten, 8-methoxypsoralen, alkaloid, gas, plant, differential diagnosis, phototoxic contact dermatitis Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis .	[ "We", "report", "two", "patients", "with", "bullous", "phototoxic", "contact", "dermatitis", "caused", "by", "Dictamnus", "albus", "L.", "(", "gas", "plant", ")", "which", "belongs", "to", "the", "Rutaceae", "family", ".", "In", "both", "cases", "long", "lasting", "postinflammatory", "hyperpigmentations", "were", "observed", "as", "a", "result", "of", "the", "phototoxic", "contact", "dermatitis", ".", "The", "phototoxic", "components", "of", "Dictamnus", "albus", "L.", "are", "the", "furocoumarins", "5-methoxypsoralen", "(", "bergapten", ")", "and", "8-methoxypsoralen", ",", "and", "the", "alkaloid", "dictamnin", "whose", "phototoxic", "properties", "were", "recently", "discovered", ".", "Even", "though", "reactions", "to", "the", "gas", "plant", "have", "been", "infrequently", "reported", ",", "it", "is", "becoming", "more", "popular", "with", "gardenus", "and", "should", "be", "considered", "in", "the", "differential", "diagnosis", "of", "phototoxic", "contact", "dermatitis", "." ]	[ "umlsterm" ]
patients, phototoxic contact dermatitis, albus, gas, plant, family, phototoxic contact dermatitis, albus, furocoumarins, 5-methoxypsoralen, bergapten, 8-methoxypsoralen, alkaloid, gas, plant, differential diagnosis, phototoxic contact dermatitis	DerHautarzt.60470708.eng.abstr_task2	Sentence: We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis .	[ "We", "report", "two", "patients", "with", "bullous", "phototoxic", "contact", "dermatitis", "caused", "by", "Dictamnus", "albus", "L.", "(", "gas", "plant", ")", "which", "belongs", "to", "the", "Rutaceae", "family", ".", "In", "both", "cases", "long", "lasting", "postinflammatory", "hyperpigmentations", "were", "observed", "as", "a", "result", "of", "the", "phototoxic", "contact", "dermatitis", ".", "The", "phototoxic", "components", "of", "Dictamnus", "albus", "L.", "are", "the", "furocoumarins", "5-methoxypsoralen", "(", "bergapten", ")", "and", "8-methoxypsoralen", ",", "and", "the", "alkaloid", "dictamnin", "whose", "phototoxic", "properties", "were", "recently", "discovered", ".", "Even", "though", "reactions", "to", "the", "gas", "plant", "have", "been", "infrequently", "reported", ",", "it", "is", "becoming", "more", "popular", "with", "gardenus", "and", "should", "be", "considered", "in", "the", "differential", "diagnosis", "of", "phototoxic", "contact", "dermatitis", "." ]	[ "umlsterm" ]
ulcerative is a Pathological_formation, colorectal is a Multi-tissue_structure, colorectal dysplasia is a Pathological_formation, cancer is a Cancer, ulcerative is a Pathological_formation, colon cancer is a Cancer, colon cancer is a Cancer, colonic tumors is a Cancer, dysplasia is a Pathological_formation, adenocarcinoma is a Cancer, high - grade lesions is a Pathological_formation, high - grade dysplasia is a Pathological_formation, carcinoma in situ is a Cancer, invasive adenocarcinoma is a Cancer, high - grade lesions is a Pathological_formation, high - grade lesions is a Pathological_formation, colorectal is a Multi-tissue_structure, colorectal is a Multi-tissue_structure, colorectal is a Multi-tissue_structure	PMID-14652292_task0	Sentence: Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Pathological_formation, Cancer, Multi-tissue_structure	[ "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "B-Cancer", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "B-Cancer", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "B-Cancer", "I-Cancer", "I-Cancer", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O" ]	Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model.	[ "Effects", "of", "dietary", "folate", "on", "ulcerative", "colitis", "-", "associated", "colorectal", "carcinogenesis", "in", "the", "interleukin", "2-", "and", "beta(2)-microglobulin", "-", "deficient", "mice", ".", "\n", "Folate", "supplementation", "may", "reduce", "the", "risk", "of", "colorectal", "dysplasia", "and", "cancer", "in", "subjects", "with", "chronic", "ulcerative", "colitis", "(", "UC", ")", ".", "The", "interleukin", "(", "IL", ")", "2-", "and", "beta(2)-microglobulin", "(", "beta(2)m)-deficient", "(", "IL-2(null", ")", "x", "beta(2)m(null", ")", ")", "mice", "spontaneously", "develop", "colon", "cancer", "in", "the", "setting", "of", "chronic", "UC", ".", "This", "study", "investigated", "the", "effects", "of", "dietary", "folate", "on", "the", "development", "of", "UC", "-", "associated", "colon", "cancer", "in", "the", "IL-2(null", ")", "x", "beta(2)m(null", ")", "mice", ".", "Weaning", "IL-2(null", ")", "x", "beta(2)m(null", ")", "mice", "were", "randomized", "to", "receive", "0", "(", "deficient", ";", "n", "=", "40", ")", ",", "2", "(", "basal", "requirement", ";", "control", ";", "n", "=", "46", ")", ",", "or", "8", "(", "supplemented", ";", "n", "=", "36", ")", "mg", "folate", "/", "kg", "diet", "for", "32", "weeks", ".", "At", "necropsy", ",", "all", "macroscopic", "colonic", "tumors", "were", "identified", "and", "histologically", "classified", "as", "dysplasia", "or", "adenocarcinoma", ".", "The", "incidence", "of", "high", "-", "grade", "lesions", "(", "high", "-", "grade", "dysplasia", "/", "carcinoma", "in", "situ", "and", "invasive", "adenocarcinoma", ")", "in", "the", "folate", "-", "supplemented", "group", "was", "46", "%", "lower", "than", "that", "in", "the", "control", "group", "(", "35.3", "%", "versus", "65.1", "%", ",", "P", "=", "0.009", ")", ".", "The", "incidence", "of", "high", "-", "grade", "lesions", "in", "the", "folate", "-", "deficient", "group", "was", "also", "49", "%", "lower", "than", "that", "in", "the", "control", "group", "(", "33.3", "%", "versus", "65.1", "%", ",", "P", "=", "0.007", ")", ".", "The", "higher", "mortality", "rate", "in", "the", "folate", "-", "deficient", "group", "compared", "with", "the", "other", "two", "groups", "(", "25", "%", "versus", "6.5", "%", "and", "5.6", "%", ",", "P", "<", "0.02", ")", "partially", "accounted", "for", "the", "low", "incidence", "of", "high", "-", "grade", "lesions", "in", "this", "group", ".", "These", "data", "indicate", "that", "dietary", "folate", "supplementation", "at", "4x", "the", "basal", "dietary", "requirement", "significantly", "suppresses", "UC", "-", "associated", "colorectal", "carcinogenesis", "in", "the", "IL-2(null", ")", "x", "beta(2)m(null", ")", "mice", ".", "These", "data", "also", "suggest", "that", "folate", "deficiency", "may", "inhibit", "colorectal", "carcinogenesis", "in", "chronic", "UC", ".", "However", ",", "the", "high", "mortality", "observed", "in", "the", "folate", "-", "deficient", "group", "precludes", "a", "definitive", "conclusion", "concerning", "the", "effect", "of", "folate", "deficiency", "on", "UC", "-", "associated", "colorectal", "carcinogenesis", "in", "this", "model", ".", "\n" ]	[ "Cancer", "Pathological_formation", "Multi-tissue_structure" ]
ulcerative is a Pathological_formation, colorectal is a Multi-tissue_structure, colorectal dysplasia is a Pathological_formation, cancer is a Cancer, ulcerative is a Pathological_formation, colon cancer is a Cancer, colon cancer is a Cancer, colonic tumors is a Cancer, dysplasia is a Pathological_formation, adenocarcinoma is a Cancer, high - grade lesions is a Pathological_formation, high - grade dysplasia is a Pathological_formation, carcinoma in situ is a Cancer, invasive adenocarcinoma is a Cancer, high - grade lesions is a Pathological_formation, high - grade lesions is a Pathological_formation, colorectal is a Multi-tissue_structure, colorectal is a Multi-tissue_structure, colorectal is a Multi-tissue_structure	PMID-14652292_task1	Sentence: Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model. Instructions: please typing these entity words according to sentence: ulcerative, colorectal, colorectal dysplasia, cancer, ulcerative, colon cancer, colon cancer, colonic tumors, dysplasia, adenocarcinoma, high - grade lesions, high - grade dysplasia, carcinoma in situ, invasive adenocarcinoma, high - grade lesions, high - grade lesions, colorectal, colorectal, colorectal Options: Pathological_formation, Cancer, Multi-tissue_structure	[ "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "B-Cancer", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "B-Cancer", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "B-Cancer", "I-Cancer", "I-Cancer", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O" ]	Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model.	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ulcerative, colorectal, colorectal dysplasia, cancer, ulcerative, colon cancer, colon cancer, colonic tumors, dysplasia, adenocarcinoma, high - grade lesions, high - grade dysplasia, carcinoma in situ, invasive adenocarcinoma, high - grade lesions, high - grade lesions, colorectal, colorectal, colorectal	PMID-14652292_task2	Sentence: Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "B-Cancer", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "B-Cancer", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "B-Cancer", "I-Cancer", "I-Cancer", "O", "B-Cancer", "I-Cancer", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O" ]	Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model.	[ "Effects", "of", "dietary", "folate", "on", "ulcerative", "colitis", "-", "associated", "colorectal", "carcinogenesis", "in", "the", "interleukin", "2-", "and", "beta(2)-microglobulin", "-", "deficient", "mice", ".", "\n", "Folate", "supplementation", "may", "reduce", "the", "risk", "of", "colorectal", "dysplasia", "and", "cancer", "in", "subjects", "with", "chronic", "ulcerative", "colitis", "(", "UC", ")", ".", "The", "interleukin", "(", "IL", ")", "2-", "and", "beta(2)-microglobulin", "(", "beta(2)m)-deficient", "(", "IL-2(null", ")", "x", "beta(2)m(null", ")", ")", "mice", "spontaneously", "develop", "colon", "cancer", "in", "the", "setting", "of", "chronic", "UC", ".", "This", "study", "investigated", "the", "effects", "of", "dietary", "folate", "on", "the", "development", "of", "UC", "-", "associated", "colon", "cancer", "in", "the", "IL-2(null", ")", "x", "beta(2)m(null", ")", "mice", ".", "Weaning", "IL-2(null", ")", "x", "beta(2)m(null", ")", "mice", "were", "randomized", "to", "receive", "0", "(", "deficient", ";", "n", "=", "40", ")", ",", "2", "(", "basal", "requirement", ";", "control", ";", "n", "=", "46", ")", ",", "or", "8", "(", "supplemented", ";", "n", "=", "36", ")", "mg", "folate", "/", "kg", "diet", "for", "32", "weeks", ".", "At", "necropsy", ",", "all", "macroscopic", "colonic", "tumors", "were", "identified", "and", "histologically", "classified", "as", "dysplasia", "or", "adenocarcinoma", ".", "The", "incidence", "of", "high", "-", "grade", "lesions", "(", "high", "-", "grade", "dysplasia", "/", "carcinoma", "in", "situ", "and", "invasive", "adenocarcinoma", ")", "in", "the", "folate", "-", "supplemented", "group", "was", "46", "%", "lower", "than", "that", "in", "the", "control", "group", "(", "35.3", "%", "versus", "65.1", "%", ",", "P", "=", "0.009", ")", ".", "The", "incidence", "of", "high", "-", "grade", "lesions", "in", "the", "folate", "-", "deficient", "group", "was", "also", "49", "%", "lower", "than", "that", "in", "the", "control", "group", "(", "33.3", "%", "versus", "65.1", "%", ",", "P", "=", "0.007", ")", ".", "The", "higher", "mortality", "rate", "in", "the", "folate", "-", "deficient", "group", "compared", "with", "the", "other", "two", "groups", "(", "25", "%", "versus", "6.5", "%", "and", "5.6", "%", ",", "P", "<", "0.02", ")", "partially", "accounted", "for", "the", "low", "incidence", "of", "high", "-", "grade", "lesions", "in", "this", "group", ".", "These", "data", "indicate", "that", "dietary", "folate", "supplementation", "at", "4x", "the", "basal", "dietary", "requirement", "significantly", "suppresses", "UC", "-", "associated", "colorectal", "carcinogenesis", "in", "the", "IL-2(null", ")", "x", "beta(2)m(null", ")", "mice", ".", "These", "data", "also", "suggest", "that", "folate", "deficiency", "may", "inhibit", "colorectal", "carcinogenesis", "in", "chronic", "UC", ".", "However", ",", "the", "high", "mortality", "observed", "in", "the", "folate", "-", "deficient", "group", "precludes", "a", "definitive", "conclusion", "concerning", "the", "effect", "of", "folate", "deficiency", "on", "UC", "-", "associated", "colorectal", "carcinogenesis", "in", "this", "model", ".", "\n" ]	[ "Cancer", "Pathological_formation", "Multi-tissue_structure" ]
Patienten is an umlsterm, Diagnostik is an umlsterm, Diagnostik is an umlsterm, neurologische Untersuchung is an umlsterm, Farbdoppler is an umlsterm, Patienten is an umlsterm, ACC is an umlsterm, ACC is an umlsterm, Atlasschlinge is an umlsterm, Patienten is an umlsterm, Angiographie is an umlsterm	Gefaesschirurgie.80030088.ger.abstr_task0	Sentence: Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation .	[ "Die", "Indikation", "zur", "Vertebralisrekonstruktion", "ist", "im", "Gegensatz", "zu", "den", "Eingriffen", "an", "der", "Karotisstrombahn", "nicht", "standardisiert", ".", "In", "einer", "prospektiven", "Untersuchung", "an", "44", "Patienten", "sollte", "gezeigt", "werden", ",", "ob", "eine", "erweiterte", "praeoperative", "Diagnostik", "die", "Entscheidung", "zum", "operativen", "Vorgehen", "erleichtern", "kann", ".", "Die", "Diagnostik", "beinhaltete", "i", ".", "a.", "DSA", ",", "CCT", ",", "MRT", ",", "Langzeit", "-", "EKG", ",", "otoneurologische", "und", "neurologische", "Untersuchung", "und", "Vertebralisflussmessung", "mittels", "Farbdoppler", ".", "Wir", "verglichen", "die", "prae-", "u.", "postoperativen", "Befunde", "mit", "den", "subjektiven", "Beschwerden", "der", "Patienten", ".", "Operativ", "wurde", "entweder", "eine", "Vertebralistransposition", "in", "die", "ACC", "vorgenommen", "oder", "ein", "C1-Bypass", "zwischen", "ACC", "und", "Atlasschlinge", "implantiert", ".", "Bei", "der", "Nachuntersuchung", "6", "-", "9", "Monate", "postoperativ", "waren", "72", "%", "der", "Patienten", "deutlich", "gebessert", "oder", "beschwerdefrei", ".", "Die", "Validitaet", "der", "angewandten", "Diagnostika", "in", "Hinblick", "auf", "einen", "Operationserfolg", "enttaeuschte", ",", "insbesondere", "die", "Vertebralisflussmessung", ".", "Fuer", "uns", "sind", "nach", "ueber", "600", "Eingriffen", "seit", "1980", "weiterhin", "exakte", "Anamnese", "und", "suffiziente", "Angiographie", "entscheidend", "fuer", "die", "Operationsindikation", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, Diagnostik is an umlsterm, Diagnostik is an umlsterm, neurologische Untersuchung is an umlsterm, Farbdoppler is an umlsterm, Patienten is an umlsterm, ACC is an umlsterm, ACC is an umlsterm, Atlasschlinge is an umlsterm, Patienten is an umlsterm, Angiographie is an umlsterm	Gefaesschirurgie.80030088.ger.abstr_task1	Sentence: Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation . Instructions: please typing these entity words according to sentence: Patienten, Diagnostik, Diagnostik, neurologische Untersuchung, Farbdoppler, Patienten, ACC, ACC, Atlasschlinge, Patienten, Angiographie Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation .	[ "Die", "Indikation", "zur", "Vertebralisrekonstruktion", "ist", "im", "Gegensatz", "zu", "den", "Eingriffen", "an", "der", "Karotisstrombahn", "nicht", "standardisiert", ".", "In", "einer", "prospektiven", "Untersuchung", "an", "44", "Patienten", "sollte", "gezeigt", "werden", ",", "ob", "eine", "erweiterte", "praeoperative", "Diagnostik", "die", "Entscheidung", "zum", "operativen", "Vorgehen", "erleichtern", "kann", ".", "Die", "Diagnostik", "beinhaltete", "i", ".", "a.", "DSA", ",", "CCT", ",", "MRT", ",", "Langzeit", "-", "EKG", ",", "otoneurologische", "und", "neurologische", "Untersuchung", "und", "Vertebralisflussmessung", "mittels", "Farbdoppler", ".", "Wir", "verglichen", "die", "prae-", "u.", "postoperativen", "Befunde", "mit", "den", "subjektiven", "Beschwerden", "der", "Patienten", ".", "Operativ", "wurde", "entweder", "eine", "Vertebralistransposition", "in", "die", "ACC", "vorgenommen", "oder", "ein", "C1-Bypass", "zwischen", "ACC", "und", "Atlasschlinge", "implantiert", ".", "Bei", "der", "Nachuntersuchung", "6", "-", "9", "Monate", "postoperativ", "waren", "72", "%", "der", "Patienten", "deutlich", "gebessert", "oder", "beschwerdefrei", ".", "Die", "Validitaet", "der", "angewandten", "Diagnostika", "in", "Hinblick", "auf", "einen", "Operationserfolg", "enttaeuschte", ",", "insbesondere", "die", "Vertebralisflussmessung", ".", "Fuer", "uns", "sind", "nach", "ueber", "600", "Eingriffen", "seit", "1980", "weiterhin", "exakte", "Anamnese", "und", "suffiziente", "Angiographie", "entscheidend", "fuer", "die", "Operationsindikation", "." ]	[ "umlsterm" ]
Patienten, Diagnostik, Diagnostik, neurologische Untersuchung, Farbdoppler, Patienten, ACC, ACC, Atlasschlinge, Patienten, Angiographie	Gefaesschirurgie.80030088.ger.abstr_task2	Sentence: Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O" ]	Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation .	[ "Die", "Indikation", "zur", "Vertebralisrekonstruktion", "ist", "im", "Gegensatz", "zu", "den", "Eingriffen", "an", "der", "Karotisstrombahn", "nicht", "standardisiert", ".", "In", "einer", "prospektiven", "Untersuchung", "an", "44", "Patienten", "sollte", "gezeigt", "werden", ",", "ob", "eine", "erweiterte", "praeoperative", "Diagnostik", "die", "Entscheidung", "zum", "operativen", "Vorgehen", "erleichtern", "kann", ".", "Die", "Diagnostik", "beinhaltete", "i", ".", "a.", "DSA", ",", "CCT", ",", "MRT", ",", "Langzeit", "-", "EKG", ",", "otoneurologische", "und", "neurologische", "Untersuchung", "und", "Vertebralisflussmessung", "mittels", "Farbdoppler", ".", "Wir", "verglichen", "die", "prae-", "u.", "postoperativen", "Befunde", "mit", "den", "subjektiven", "Beschwerden", "der", "Patienten", ".", "Operativ", "wurde", "entweder", "eine", "Vertebralistransposition", "in", "die", "ACC", "vorgenommen", "oder", "ein", "C1-Bypass", "zwischen", "ACC", "und", "Atlasschlinge", "implantiert", ".", "Bei", "der", "Nachuntersuchung", "6", "-", "9", "Monate", "postoperativ", "waren", "72", "%", "der", "Patienten", "deutlich", "gebessert", "oder", "beschwerdefrei", ".", "Die", "Validitaet", "der", "angewandten", "Diagnostika", "in", "Hinblick", "auf", "einen", "Operationserfolg", "enttaeuschte", ",", "insbesondere", "die", "Vertebralisflussmessung", ".", "Fuer", "uns", "sind", "nach", "ueber", "600", "Eingriffen", "seit", "1980", "weiterhin", "exakte", "Anamnese", "und", "suffiziente", "Angiographie", "entscheidend", "fuer", "die", "Operationsindikation", "." ]	[ "umlsterm" ]
cyproheptadine is a Intervention_Pharmacological, in human plasma is a Participant_Condition, Chromatography is a Intervention_Physical	49789_task0	Sentence: Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Intervention_Pharmacological, Participant_Condition	[ "O", "O", "B-Intervention_Pharmacological", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine .	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cyproheptadine is a Intervention_Pharmacological, in human plasma is a Participant_Condition, Chromatography is a Intervention_Physical	49789_task1	Sentence: Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine . Instructions: please typing these entity words according to sentence: cyproheptadine, in human plasma, Chromatography Options: Intervention_Physical, Intervention_Pharmacological, Participant_Condition	[ "O", "O", "B-Intervention_Pharmacological", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine .	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cyproheptadine, in human plasma, Chromatography	49789_task2	Sentence: Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Intervention_Pharmacological", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine .	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intravenoese Anaesthesie is an umlsterm, Tageschirurgie is an umlsterm, Wiederherstellung is an umlsterm, Doppelblindstudie is an umlsterm, Patienten is an umlsterm, Cholezystektomie is an umlsterm, Propofol is an umlsterm, Methohexital is an umlsterm, Isofluran is an umlsterm, Merkfaehigkeit is an umlsterm, Schmerz is an umlsterm, Uebelkeit is an umlsterm, Muedigkeit is an umlsterm, Propofol is an umlsterm, Patienten is an umlsterm, Methohexital is an umlsterm, Isofluran is an umlsterm, Patienten is an umlsterm, Uebelkeit is an umlsterm, Isofluran is an umlsterm, Patienten is an umlsterm, laparoskopische Cholezystektomie is an umlsterm, Anaesthesieverfahren is an umlsterm	DerAnaesthesist.40430573.ger.abstr_task0	Sentence: Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden .	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intravenoese Anaesthesie is an umlsterm, Tageschirurgie is an umlsterm, Wiederherstellung is an umlsterm, Doppelblindstudie is an umlsterm, Patienten is an umlsterm, Cholezystektomie is an umlsterm, Propofol is an umlsterm, Methohexital is an umlsterm, Isofluran is an umlsterm, Merkfaehigkeit is an umlsterm, Schmerz is an umlsterm, Uebelkeit is an umlsterm, Muedigkeit is an umlsterm, Propofol is an umlsterm, Patienten is an umlsterm, Methohexital is an umlsterm, Isofluran is an umlsterm, Patienten is an umlsterm, Uebelkeit is an umlsterm, Isofluran is an umlsterm, Patienten is an umlsterm, laparoskopische Cholezystektomie is an umlsterm, Anaesthesieverfahren is an umlsterm	DerAnaesthesist.40430573.ger.abstr_task1	Sentence: Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden . Instructions: please typing these entity words according to sentence: intravenoese Anaesthesie, Tageschirurgie, Wiederherstellung, Doppelblindstudie, Patienten, Cholezystektomie, Propofol, Methohexital, Isofluran, Merkfaehigkeit, Schmerz, Uebelkeit, Muedigkeit, Propofol, Patienten, Methohexital, Isofluran, Patienten, Uebelkeit, Isofluran, Patienten, laparoskopische Cholezystektomie, Anaesthesieverfahren Options: umlsterm	[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden .	[ "Die", "totale", "intravenoese", "Anaesthesie", "(", "TIVA", ")", "wird", "in", "der", "Tageschirurgie", "zunehmend", "eingesetzt", ",", "weil", "schnelleres", "Erwachen", "und", "eine", "raschere", "Wiederherstellung", "der", "psychomotorischen", "Funktionen", "erwartet", "werden", ".", "In", "einer", "randomisierten", "Doppelblindstudie", "an", "51", "Patienten", "zur", "laparoskopischen", "Cholezystektomie", "wurde", "das", "Aufwachverhalten", "nach", "einer", "TIVA", "mit", "Propofol", ",", "einer", "TIVA", "mit", "Methohexital", "und", "einer", "balanced", "anaesthesia", "mit", "Isofluran", "in", "den", "ersten", "6", "Stunden", "postoperativ", "anhand", "der", "Aufwachzeit", ",", "der", "Orientiertheit", ",", "der", "Merkfaehigkeit", ",", "eines", "Rechentests", "und", "der", "Wortgenerierungsfaehigkeit", "untersucht", ".", "Die", "Befindlichkeit", "wurde", "mit", "einer", "visuellen", "Analogskala", "fuer", "Schmerz", ",", "Uebelkeit", "und", "Muedigkeit", "beurteilt", ".", "Nach", "der", "TIVA", "mit", "Propofol", "erwachten", "die", "Patienten", "schneller", "als", "nach", "Methohexital", "und", "auch", "geringfuegig", "schneller", "als", "nach", "Isofluran", ".", "Mit", "dem", "Verzicht", "auf", "Lachgas", "ist", "die", "Quote", "der", "Patienten", ",", "die", "ueber", "Uebelkeit", "klagten", ",", "auch", "nach", "Isofluran", "erstaunlich", "klein", "(", "24", "%", ")", ".", "Die", "Unterschiede", "in", "den", "drei", "Gruppen", "sind", "insgesamt", "gering", ",", "insbesondere", "sind", "die", "Kooperationsfaehigkeit", "und", "die", "Mobilisierbarkeit", "der", "Patienten", "in", "keiner", "Gruppe", "eingeschraenkt", ".", "Fuer", "die", "laparoskopische", "Cholezystektomie", "koennen", "alle", "drei", "untersuchten", "Anaesthesieverfahren", "als", "gut", "geeignet", "angesehen", "werden", "." ]	[ "umlsterm" ]
intravenoese Anaesthesie, Tageschirurgie, Wiederherstellung, Doppelblindstudie, Patienten, Cholezystektomie, Propofol, Methohexital, Isofluran, Merkfaehigkeit, Schmerz, Uebelkeit, Muedigkeit, Propofol, Patienten, Methohexital, Isofluran, Patienten, Uebelkeit, Isofluran, Patienten, laparoskopische Cholezystektomie, Anaesthesieverfahren	DerAnaesthesist.40430573.ger.abstr_task2	Sentence: Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden .	[ "Die", "totale", "intravenoese", "Anaesthesie", "(", "TIVA", ")", "wird", "in", "der", "Tageschirurgie", "zunehmend", "eingesetzt", ",", "weil", "schnelleres", "Erwachen", "und", "eine", "raschere", "Wiederherstellung", "der", "psychomotorischen", "Funktionen", "erwartet", "werden", ".", "In", "einer", "randomisierten", "Doppelblindstudie", "an", "51", "Patienten", "zur", "laparoskopischen", "Cholezystektomie", "wurde", "das", "Aufwachverhalten", "nach", "einer", "TIVA", "mit", "Propofol", ",", "einer", "TIVA", "mit", "Methohexital", "und", "einer", "balanced", "anaesthesia", "mit", "Isofluran", "in", "den", "ersten", "6", "Stunden", "postoperativ", "anhand", "der", "Aufwachzeit", ",", "der", "Orientiertheit", ",", "der", "Merkfaehigkeit", ",", "eines", "Rechentests", "und", "der", "Wortgenerierungsfaehigkeit", "untersucht", ".", "Die", "Befindlichkeit", "wurde", "mit", "einer", "visuellen", "Analogskala", "fuer", "Schmerz", ",", "Uebelkeit", "und", "Muedigkeit", "beurteilt", ".", "Nach", "der", "TIVA", "mit", "Propofol", "erwachten", "die", "Patienten", "schneller", "als", "nach", "Methohexital", "und", "auch", "geringfuegig", "schneller", "als", "nach", "Isofluran", ".", "Mit", "dem", "Verzicht", "auf", "Lachgas", "ist", "die", "Quote", "der", "Patienten", ",", "die", "ueber", "Uebelkeit", "klagten", ",", "auch", "nach", "Isofluran", "erstaunlich", "klein", "(", "24", "%", ")", ".", "Die", "Unterschiede", "in", "den", "drei", "Gruppen", "sind", "insgesamt", "gering", ",", "insbesondere", "sind", "die", "Kooperationsfaehigkeit", "und", "die", "Mobilisierbarkeit", "der", "Patienten", "in", "keiner", "Gruppe", "eingeschraenkt", ".", "Fuer", "die", "laparoskopische", "Cholezystektomie", "koennen", "alle", "drei", "untersuchten", "Anaesthesieverfahren", "als", "gut", "geeignet", "angesehen", "werden", "." ]	[ "umlsterm" ]
Pyridoxal 5'-phosphate is a CHEMICAL, pyridox(am)ine-5'-phosphate oxidase is a GENE-Y, PNPO is a GENE-Y, pyridoxal 5'-phosphate is a CHEMICAL, PLP is a CHEMICAL, PLP is a CHEMICAL, PNPO is a GENE-Y	11702_task0	Sentence: Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL	[ "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O" ]	Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency.	[ "Pyridoxal", "5'-phosphate", "may", "be", "curative", "in", "early", "-", "onset", "epileptic", "encephalopathy", ".", "\n", "Neonatal", "epileptic", "encephalopathy", "can", "be", "caused", "by", "inborn", "errors", "of", "metabolism", ".", "These", "conditions", "are", "often", "unresponsive", "to", "treatment", "with", "conventional", "antiepileptic", "drugs", ".", "Six", "children", "with", "pyridox(am)ine-5'-phosphate", "oxidase", "(", "PNPO", ")", "deficiency", "presented", "with", "neonatal", "epileptic", "encephalopathy", ".", "Two", "were", "treated", "with", "pyridoxal", "5'-phosphate", "(", "PLP", ")", "within", "the", "first", "month", "of", "life", "and", "showed", "normal", "development", "or", "moderate", "psychomotor", "retardation", "thereafter", ".", "Four", "children", "with", "late", "or", "no", "treatment", "died", "or", "showed", "severe", "mental", "handicap", ".", "All", "of", "the", "children", "showed", "atypical", "biochemical", "findings", ".", "Prompt", "treatment", "with", "PLP", "in", "all", "neonates", "and", "infants", "with", "epileptic", "encephalopathy", "should", "become", "mandatory", ",", "permitting", "normal", "development", "in", "at", "least", "some", "of", "those", "affected", "with", "PNPO", "deficiency", "." ]	[ "GENE-Y", "CHEMICAL" ]
Pyridoxal 5'-phosphate is a CHEMICAL, pyridox(am)ine-5'-phosphate oxidase is a GENE-Y, PNPO is a GENE-Y, pyridoxal 5'-phosphate is a CHEMICAL, PLP is a CHEMICAL, PLP is a CHEMICAL, PNPO is a GENE-Y	11702_task1	Sentence: Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency. Instructions: please typing these entity words according to sentence: Pyridoxal 5'-phosphate, pyridox(am)ine-5'-phosphate oxidase, PNPO, pyridoxal 5'-phosphate, PLP, PLP, PNPO Options: GENE-Y, CHEMICAL	[ "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O" ]	Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency.	[ "Pyridoxal", "5'-phosphate", "may", "be", "curative", "in", "early", "-", "onset", "epileptic", "encephalopathy", ".", "\n", "Neonatal", "epileptic", "encephalopathy", "can", "be", "caused", "by", "inborn", "errors", "of", "metabolism", ".", "These", "conditions", "are", "often", "unresponsive", "to", "treatment", "with", "conventional", "antiepileptic", "drugs", ".", "Six", "children", "with", "pyridox(am)ine-5'-phosphate", "oxidase", "(", "PNPO", ")", "deficiency", "presented", "with", "neonatal", "epileptic", "encephalopathy", ".", "Two", "were", "treated", "with", "pyridoxal", "5'-phosphate", "(", "PLP", ")", "within", "the", "first", "month", "of", "life", "and", "showed", "normal", "development", "or", "moderate", "psychomotor", "retardation", "thereafter", ".", "Four", "children", "with", "late", "or", "no", "treatment", "died", "or", "showed", "severe", "mental", "handicap", ".", "All", "of", "the", "children", "showed", "atypical", "biochemical", "findings", ".", "Prompt", "treatment", "with", "PLP", "in", "all", "neonates", "and", "infants", "with", "epileptic", "encephalopathy", "should", "become", "mandatory", ",", "permitting", "normal", "development", "in", "at", "least", "some", "of", "those", "affected", "with", "PNPO", "deficiency", "." ]	[ "GENE-Y", "CHEMICAL" ]
Pyridoxal 5'-phosphate, pyridox(am)ine-5'-phosphate oxidase, PNPO, pyridoxal 5'-phosphate, PLP, PLP, PNPO	11702_task2	Sentence: Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency. Instructions: please extract entity words from the input sentence	[ "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O" ]	Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency.	[ "Pyridoxal", "5'-phosphate", "may", "be", "curative", "in", "early", "-", "onset", "epileptic", "encephalopathy", ".", "\n", "Neonatal", "epileptic", "encephalopathy", "can", "be", "caused", "by", "inborn", "errors", "of", "metabolism", ".", "These", "conditions", "are", "often", "unresponsive", "to", "treatment", "with", "conventional", "antiepileptic", "drugs", ".", "Six", "children", "with", "pyridox(am)ine-5'-phosphate", "oxidase", "(", "PNPO", ")", "deficiency", "presented", "with", "neonatal", "epileptic", "encephalopathy", ".", "Two", "were", "treated", "with", "pyridoxal", "5'-phosphate", "(", "PLP", ")", "within", "the", "first", "month", "of", "life", "and", "showed", "normal", "development", "or", "moderate", "psychomotor", "retardation", "thereafter", ".", "Four", "children", "with", "late", "or", "no", "treatment", "died", "or", "showed", "severe", "mental", "handicap", ".", "All", "of", "the", "children", "showed", "atypical", "biochemical", "findings", ".", "Prompt", "treatment", "with", "PLP", "in", "all", "neonates", "and", "infants", "with", "epileptic", "encephalopathy", "should", "become", "mandatory", ",", "permitting", "normal", "development", "in", "at", "least", "some", "of", "those", "affected", "with", "PNPO", "deficiency", "." ]	[ "GENE-Y", "CHEMICAL" ]
Patienten is an umlsterm, vorderen Kreuzbandes is an umlsterm, Fragebogen is an umlsterm, Patienten is an umlsterm, Beurteilung is an umlsterm, Patienten is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Kohlefaserprothesen is an umlsterm, Zeit is an umlsterm, Prothesen is an umlsterm, Rolle is an umlsterm, Langzeitverlauf is an umlsterm, Synovitis is an umlsterm, Enzymreaktionen is an umlsterm, Gelenkdestruktion is an umlsterm, Gelenkerguesse is an umlsterm, Schmerzen is an umlsterm	DerChirurg.70681119.ger.abstr_task0	Sentence: Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert .	[ "Zusammenfassung", ".", "120", "Patienten", "nach", "Ersatz", "des", "vorderen", "Kreuzbandes", "(", "VKB", ")", "mit", "La", "-", "Fil", "-", "Kohlefaserprothese", "wurden", "retrospektiv", "mittels", "Fragebogen", "und", "80", "Patienten", "klinisch", "nach", "im", "Mittel", "10", "+", "/-", "2", "Jahren", "untersucht", ".", "Die", "subjektive", "Beurteilung", "ergab", "60", "%", "zufriedene", "Patienten", "bei", "deutlich", "vermindertem", "Aktivitaetsniveau", ".", "Als", "objektive", "Komplikationen", "waren", "bei", "72,5", "%", "der", "Patienten", "die", "C", "-", "Faser", "rupturiert", "und", "bei", "68", "%", "der", "Patienten", "synoviale", "Reaktionen", "zu", "beobachten", ".", "Roentgenologisch", "zeigten", "sich", "in", "bis", "zu", "59", "%", "der", "Faelle", "arthrotische", "Veraenderungen", ".", "Die", "mit", "C", "-", "Faser", "rekonstruierten", "Collateralbaender", "(", "85", "%", "medial", ",", "5,8", "%", "lateral", ")", "waren", "zu", "75", "%", "stabil", ".", "Fuer", "das", "Versagen", "der", "Kohlefaserprothesen", "scheinen", "weniger", "die", "Aktivitaet", "oder", "die", "Zeit", "als", "vielmehr", "das", "Einwachsverhalten", "der", "Prothesen", "eine", "Rolle", "zu", "spielen", ".", "Im", "Langzeitverlauf", "fuehrt", "die", "reaktive", "Synovitis", "ueber", "katabole", "Enzymreaktionen", "zur", "Gelenkdestruktion", ".", "Klinische", "Zeichen", "sind", "rezidivierende", "Gelenkerguesse", "und", "Schmerzen", ".", "Zur", "Unterbrechung", "des", "Circulus", "vitiosus", "ist", "die", "arthroskopische", ")", "Synovektomie", "(", "indiziert", "." ]	[ "umlsterm" ]
Patienten is an umlsterm, vorderen Kreuzbandes is an umlsterm, Fragebogen is an umlsterm, Patienten is an umlsterm, Beurteilung is an umlsterm, Patienten is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Kohlefaserprothesen is an umlsterm, Zeit is an umlsterm, Prothesen is an umlsterm, Rolle is an umlsterm, Langzeitverlauf is an umlsterm, Synovitis is an umlsterm, Enzymreaktionen is an umlsterm, Gelenkdestruktion is an umlsterm, Gelenkerguesse is an umlsterm, Schmerzen is an umlsterm	DerChirurg.70681119.ger.abstr_task1	Sentence: Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert . Instructions: please typing these entity words according to sentence: Patienten, vorderen Kreuzbandes, Fragebogen, Patienten, Beurteilung, Patienten, Komplikationen, Patienten, Patienten, Kohlefaserprothesen, Zeit, Prothesen, Rolle, Langzeitverlauf, Synovitis, Enzymreaktionen, Gelenkdestruktion, Gelenkerguesse, Schmerzen Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert .	[ "Zusammenfassung", ".", "120", "Patienten", "nach", "Ersatz", "des", "vorderen", "Kreuzbandes", "(", "VKB", ")", "mit", "La", "-", "Fil", "-", "Kohlefaserprothese", "wurden", "retrospektiv", "mittels", "Fragebogen", "und", "80", "Patienten", "klinisch", "nach", "im", "Mittel", "10", "+", "/-", "2", "Jahren", "untersucht", ".", "Die", "subjektive", "Beurteilung", "ergab", "60", "%", "zufriedene", "Patienten", "bei", "deutlich", "vermindertem", "Aktivitaetsniveau", ".", "Als", "objektive", "Komplikationen", "waren", "bei", "72,5", "%", "der", "Patienten", "die", "C", "-", "Faser", "rupturiert", "und", "bei", "68", "%", "der", "Patienten", "synoviale", "Reaktionen", "zu", "beobachten", ".", "Roentgenologisch", "zeigten", "sich", "in", "bis", "zu", "59", "%", "der", "Faelle", "arthrotische", "Veraenderungen", ".", "Die", "mit", "C", "-", "Faser", "rekonstruierten", "Collateralbaender", "(", "85", "%", "medial", ",", "5,8", "%", "lateral", ")", "waren", "zu", "75", "%", "stabil", ".", "Fuer", "das", "Versagen", "der", "Kohlefaserprothesen", "scheinen", "weniger", "die", "Aktivitaet", "oder", "die", "Zeit", "als", "vielmehr", "das", "Einwachsverhalten", "der", "Prothesen", "eine", "Rolle", "zu", "spielen", ".", "Im", "Langzeitverlauf", "fuehrt", "die", "reaktive", "Synovitis", "ueber", "katabole", "Enzymreaktionen", "zur", "Gelenkdestruktion", ".", "Klinische", "Zeichen", "sind", "rezidivierende", "Gelenkerguesse", "und", "Schmerzen", ".", "Zur", "Unterbrechung", "des", "Circulus", "vitiosus", "ist", "die", "arthroskopische", ")", "Synovektomie", "(", "indiziert", "." ]	[ "umlsterm" ]
Patienten, vorderen Kreuzbandes, Fragebogen, Patienten, Beurteilung, Patienten, Komplikationen, Patienten, Patienten, Kohlefaserprothesen, Zeit, Prothesen, Rolle, Langzeitverlauf, Synovitis, Enzymreaktionen, Gelenkdestruktion, Gelenkerguesse, Schmerzen	DerChirurg.70681119.ger.abstr_task2	Sentence: Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert .	[ "Zusammenfassung", ".", "120", "Patienten", "nach", "Ersatz", "des", "vorderen", "Kreuzbandes", "(", "VKB", ")", "mit", "La", "-", "Fil", "-", "Kohlefaserprothese", "wurden", "retrospektiv", "mittels", "Fragebogen", "und", "80", "Patienten", "klinisch", "nach", "im", "Mittel", "10", "+", "/-", "2", "Jahren", "untersucht", ".", "Die", "subjektive", "Beurteilung", "ergab", "60", "%", "zufriedene", "Patienten", "bei", "deutlich", "vermindertem", "Aktivitaetsniveau", ".", "Als", "objektive", "Komplikationen", "waren", "bei", "72,5", "%", "der", "Patienten", "die", "C", "-", "Faser", "rupturiert", "und", "bei", "68", "%", "der", "Patienten", "synoviale", "Reaktionen", "zu", "beobachten", ".", "Roentgenologisch", "zeigten", "sich", "in", "bis", "zu", "59", "%", "der", "Faelle", "arthrotische", "Veraenderungen", ".", "Die", "mit", "C", "-", "Faser", "rekonstruierten", "Collateralbaender", "(", "85", "%", "medial", ",", "5,8", "%", "lateral", ")", "waren", "zu", "75", "%", "stabil", ".", "Fuer", "das", "Versagen", "der", "Kohlefaserprothesen", "scheinen", "weniger", "die", "Aktivitaet", "oder", "die", "Zeit", "als", "vielmehr", "das", "Einwachsverhalten", "der", "Prothesen", "eine", "Rolle", "zu", "spielen", ".", "Im", "Langzeitverlauf", "fuehrt", "die", "reaktive", "Synovitis", "ueber", "katabole", "Enzymreaktionen", "zur", "Gelenkdestruktion", ".", "Klinische", "Zeichen", "sind", "rezidivierende", "Gelenkerguesse", "und", "Schmerzen", ".", "Zur", "Unterbrechung", "des", "Circulus", "vitiosus", "ist", "die", "arthroskopische", ")", "Synovektomie", "(", "indiziert", "." ]	[ "umlsterm" ]
juveniles Xanthogranulom is an umlsterm, Diagnose is an umlsterm, Riesenzellen is an umlsterm, Natur is an umlsterm	DerHautarzt.50460194.ger.abstr_task0	Sentence: Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern .	[ "Zusammenfassung", ".", "Es", "wird", "ueber", "ein", "grossknotiges", "multizentrisches", "juveniles", "Xanthogranulom", "berichtet", ",", "dessen", "ungewoehnlicher", "klinischer", "und", "histologischer", "Aspekt", "die", "Diagnose", "anfaenglich", "nicht", "zuliess", ".", "Die", "inzwischen", "mehr", "als", "2", "Jahre", "waehrende", "Spontanregression", "mit", "der", "Aenderung", "des", "primaer", "monomorphen", "fibrozytischen", "hin", "zu", "einem", "polymorphen", "histiozytischen", "Aspekt", "mit", "zahlreichen", "fettspeichernden", "Riesenzellen", "sowie", "der", "fehlende", "Nachweis", "spezifischer", "Zellorganellen", "konnten", "die", "Natur", "der", "Erkrankung", "sichern", "." ]	[ "umlsterm" ]
juveniles Xanthogranulom is an umlsterm, Diagnose is an umlsterm, Riesenzellen is an umlsterm, Natur is an umlsterm	DerHautarzt.50460194.ger.abstr_task1	Sentence: Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern . Instructions: please typing these entity words according to sentence: juveniles Xanthogranulom, Diagnose, Riesenzellen, Natur Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern .	[ "Zusammenfassung", ".", "Es", "wird", "ueber", "ein", "grossknotiges", "multizentrisches", "juveniles", "Xanthogranulom", "berichtet", ",", "dessen", "ungewoehnlicher", "klinischer", "und", "histologischer", "Aspekt", "die", "Diagnose", "anfaenglich", "nicht", "zuliess", ".", "Die", "inzwischen", "mehr", "als", "2", "Jahre", "waehrende", "Spontanregression", "mit", "der", "Aenderung", "des", "primaer", "monomorphen", "fibrozytischen", "hin", "zu", "einem", "polymorphen", "histiozytischen", "Aspekt", "mit", "zahlreichen", "fettspeichernden", "Riesenzellen", "sowie", "der", "fehlende", "Nachweis", "spezifischer", "Zellorganellen", "konnten", "die", "Natur", "der", "Erkrankung", "sichern", "." ]	[ "umlsterm" ]
juveniles Xanthogranulom, Diagnose, Riesenzellen, Natur	DerHautarzt.50460194.ger.abstr_task2	Sentence: Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]	Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern .	[ "Zusammenfassung", ".", "Es", "wird", "ueber", "ein", "grossknotiges", "multizentrisches", "juveniles", "Xanthogranulom", "berichtet", ",", "dessen", "ungewoehnlicher", "klinischer", "und", "histologischer", "Aspekt", "die", "Diagnose", "anfaenglich", "nicht", "zuliess", ".", "Die", "inzwischen", "mehr", "als", "2", "Jahre", "waehrende", "Spontanregression", "mit", "der", "Aenderung", "des", "primaer", "monomorphen", "fibrozytischen", "hin", "zu", "einem", "polymorphen", "histiozytischen", "Aspekt", "mit", "zahlreichen", "fettspeichernden", "Riesenzellen", "sowie", "der", "fehlende", "Nachweis", "spezifischer", "Zellorganellen", "konnten", "die", "Natur", "der", "Erkrankung", "sichern", "." ]	[ "umlsterm" ]
respiratory distress syndrome is an umlsterm, ARDS is an umlsterm, mortality rate is an umlsterm, trend is an umlsterm, survival rates is an umlsterm, inspiratory is an umlsterm, oxygen is an umlsterm, concentrations is an umlsterm, tidal volumes is an umlsterm, inspiratory is an umlsterm, pressures is an umlsterm, mechanical ventilation is an umlsterm, lung is an umlsterm, ARDS is an umlsterm, sequelae is an umlsterm, therapy is an umlsterm, Mechanical ventilation is an umlsterm, ARDS is an umlsterm, lung is an umlsterm, oxygen is an umlsterm, toxicity is an umlsterm, lung is an umlsterm, anatomical is an umlsterm, forms is an umlsterm, mechanical ventilation is an umlsterm, PEEP is an umlsterm, hypercapnia is an umlsterm, body position is an umlsterm, inhalation is an umlsterm, nitric oxide is an umlsterm, procedures is an umlsterm, gas is an umlsterm, extracorporeal membrane oxygenation is an umlsterm, therapeutic is an umlsterm, therapeutic procedures is an umlsterm, standard is an umlsterm, treatment is an umlsterm, randomised controlled trial is an umlsterm, review is an umlsterm, pathophysiology is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, ARDS is an umlsterm	DerAnaesthesist.60450002.eng.abstr_task0	Sentence: Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS .	[ "Acute", "respiratory", "distress", "syndrome", "(", "ARDS", ")", "is", "rare", "but", "beset", "with", "a", "high", "mortality", "rate", ".", "In", "recent", "years", ",", "however", ",", "a", "trend", "towards", "higher", "survival", "rates", "has", "been", "observed", ".", "High", "inspiratory", "oxygen", "concentrations", ",", "large", "tidal", "volumes", ",", "and", "high", "peak", "inspiratory", "airway", "pressures", "applied", "during", "mechanical", "ventilation", "have", "been", "identified", "as", "harmful", "to", "the", "lung", "and", "can", "contribute", "to", "the", "progression", "of", "ARDS", ".", "This", "had", "led", "to", "reconsideration", "of", "the", "sequelae", "of", "ventilatory", "therapy", ".", "Mechanical", "ventilation", "and", "other", "adjunctive", "strategies", "in", "ARDS", "have", "changed", "from", "the", "conventional", "approach", "aiming", "at", "normalisation", "of", "physiological", "ventilatory", "parameters", "to", "an", "elaborated", "approach", "that", "intends", "to", "protect", "the", "ventilated", "lung", ",", "prevent", "oxygen", "toxicity", ",", "recruit", "the", "infiltrated", "atelectatic", "and", "consolidated", "lung", "and", "reduce", "the", "anatomical", "and", "alveolar", "dead", "space", ".", "This", "new", "approach", "consists", "of", "various", "forms", "of", "pressure", "-", "controlled", "mechanical", "ventilation", "with", "PEEP", "and", "permissive", "hypercapnia", ",", "body", "position", "changes", ",", "and", "inhalation", "of", "nitric", "oxide", ".", "Should", "these", "procedures", "fail", "to", "improve", "impaired", "gas", "exchange", ",", "extracorporeal", "membrane", "oxygenation", "is", "an", "additional", "therapeutic", "option", ".", "None", "of", "these", "therapeutic", "procedures", ",", "however", ",", "has", "been", "tested", "against", "traditional", "standard", "treatment", "in", "a", "classical", "randomised", "controlled", "trial", ".", "The", "following", "review", "focuses", "on", "the", "latest", "insights", "into", "the", "pathophysiology", ",", "diagnosis", ",", "and", "treatment", "of", "ARDS", "." ]	[ "umlsterm" ]
respiratory distress syndrome is an umlsterm, ARDS is an umlsterm, mortality rate is an umlsterm, trend is an umlsterm, survival rates is an umlsterm, inspiratory is an umlsterm, oxygen is an umlsterm, concentrations is an umlsterm, tidal volumes is an umlsterm, inspiratory is an umlsterm, pressures is an umlsterm, mechanical ventilation is an umlsterm, lung is an umlsterm, ARDS is an umlsterm, sequelae is an umlsterm, therapy is an umlsterm, Mechanical ventilation is an umlsterm, ARDS is an umlsterm, lung is an umlsterm, oxygen is an umlsterm, toxicity is an umlsterm, lung is an umlsterm, anatomical is an umlsterm, forms is an umlsterm, mechanical ventilation is an umlsterm, PEEP is an umlsterm, hypercapnia is an umlsterm, body position is an umlsterm, inhalation is an umlsterm, nitric oxide is an umlsterm, procedures is an umlsterm, gas is an umlsterm, extracorporeal membrane oxygenation is an umlsterm, therapeutic is an umlsterm, therapeutic procedures is an umlsterm, standard is an umlsterm, treatment is an umlsterm, randomised controlled trial is an umlsterm, review is an umlsterm, pathophysiology is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, ARDS is an umlsterm	DerAnaesthesist.60450002.eng.abstr_task1	Sentence: Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS . Instructions: please typing these entity words according to sentence: respiratory distress syndrome, ARDS, mortality rate, trend, survival rates, inspiratory, oxygen, concentrations, tidal volumes, inspiratory, pressures, mechanical ventilation, lung, ARDS, sequelae, therapy, Mechanical ventilation, ARDS, lung, oxygen, toxicity, lung, anatomical, forms, mechanical ventilation, PEEP, hypercapnia, body position, inhalation, nitric oxide, procedures, gas, extracorporeal membrane oxygenation, therapeutic, therapeutic procedures, standard, treatment, randomised controlled trial, review, pathophysiology, diagnosis, treatment, ARDS Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS .	[ "Acute", "respiratory", "distress", "syndrome", "(", "ARDS", ")", "is", "rare", "but", "beset", "with", "a", "high", "mortality", "rate", ".", "In", "recent", "years", ",", "however", ",", "a", "trend", "towards", "higher", "survival", "rates", "has", "been", "observed", ".", "High", "inspiratory", "oxygen", "concentrations", ",", "large", "tidal", "volumes", ",", "and", "high", "peak", "inspiratory", "airway", "pressures", "applied", "during", "mechanical", "ventilation", "have", "been", "identified", "as", "harmful", "to", "the", "lung", "and", "can", "contribute", "to", "the", "progression", "of", "ARDS", ".", "This", "had", "led", "to", "reconsideration", "of", "the", "sequelae", "of", "ventilatory", "therapy", ".", "Mechanical", "ventilation", "and", "other", "adjunctive", "strategies", "in", "ARDS", "have", "changed", "from", "the", "conventional", "approach", "aiming", "at", "normalisation", "of", "physiological", "ventilatory", "parameters", "to", "an", "elaborated", "approach", "that", "intends", "to", "protect", "the", "ventilated", "lung", ",", "prevent", "oxygen", "toxicity", ",", "recruit", "the", "infiltrated", "atelectatic", "and", "consolidated", "lung", "and", "reduce", "the", "anatomical", "and", "alveolar", "dead", "space", ".", "This", "new", "approach", "consists", "of", "various", "forms", "of", "pressure", "-", "controlled", "mechanical", "ventilation", "with", "PEEP", "and", "permissive", "hypercapnia", ",", "body", "position", "changes", ",", "and", "inhalation", "of", "nitric", "oxide", ".", "Should", "these", "procedures", "fail", "to", "improve", "impaired", "gas", "exchange", ",", "extracorporeal", "membrane", "oxygenation", "is", "an", "additional", "therapeutic", "option", ".", "None", "of", "these", "therapeutic", "procedures", ",", "however", ",", "has", "been", "tested", "against", "traditional", "standard", "treatment", "in", "a", "classical", "randomised", "controlled", "trial", ".", "The", "following", "review", "focuses", "on", "the", "latest", "insights", "into", "the", "pathophysiology", ",", "diagnosis", ",", "and", "treatment", "of", "ARDS", "." ]	[ "umlsterm" ]
respiratory distress syndrome, ARDS, mortality rate, trend, survival rates, inspiratory, oxygen, concentrations, tidal volumes, inspiratory, pressures, mechanical ventilation, lung, ARDS, sequelae, therapy, Mechanical ventilation, ARDS, lung, oxygen, toxicity, lung, anatomical, forms, mechanical ventilation, PEEP, hypercapnia, body position, inhalation, nitric oxide, procedures, gas, extracorporeal membrane oxygenation, therapeutic, therapeutic procedures, standard, treatment, randomised controlled trial, review, pathophysiology, diagnosis, treatment, ARDS	DerAnaesthesist.60450002.eng.abstr_task2	Sentence: Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O" ]	Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS .	[ "Acute", "respiratory", "distress", "syndrome", "(", "ARDS", ")", "is", "rare", "but", "beset", "with", "a", "high", "mortality", "rate", ".", "In", "recent", "years", ",", "however", ",", "a", "trend", "towards", "higher", "survival", "rates", "has", "been", "observed", ".", "High", "inspiratory", "oxygen", "concentrations", ",", "large", "tidal", "volumes", ",", "and", "high", "peak", "inspiratory", "airway", "pressures", "applied", "during", "mechanical", "ventilation", "have", "been", "identified", "as", "harmful", "to", "the", "lung", "and", "can", "contribute", "to", "the", "progression", "of", "ARDS", ".", "This", "had", "led", "to", "reconsideration", "of", "the", "sequelae", "of", "ventilatory", "therapy", ".", "Mechanical", "ventilation", "and", "other", "adjunctive", "strategies", "in", "ARDS", "have", "changed", "from", "the", "conventional", "approach", "aiming", "at", "normalisation", "of", "physiological", "ventilatory", "parameters", "to", "an", "elaborated", "approach", "that", "intends", "to", "protect", "the", "ventilated", "lung", ",", "prevent", "oxygen", "toxicity", ",", "recruit", "the", "infiltrated", "atelectatic", "and", "consolidated", "lung", "and", "reduce", "the", "anatomical", "and", "alveolar", "dead", "space", ".", "This", "new", "approach", "consists", "of", "various", "forms", "of", "pressure", "-", "controlled", "mechanical", "ventilation", "with", "PEEP", "and", "permissive", "hypercapnia", ",", "body", "position", "changes", ",", "and", "inhalation", "of", "nitric", "oxide", ".", "Should", "these", "procedures", "fail", "to", "improve", "impaired", "gas", "exchange", ",", "extracorporeal", "membrane", "oxygenation", "is", "an", "additional", "therapeutic", "option", ".", "None", "of", "these", "therapeutic", "procedures", ",", "however", ",", "has", "been", "tested", "against", "traditional", "standard", "treatment", "in", "a", "classical", "randomised", "controlled", "trial", ".", "The", "following", "review", "focuses", "on", "the", "latest", "insights", "into", "the", "pathophysiology", ",", "diagnosis", ",", "and", "treatment", "of", "ARDS", "." ]	[ "umlsterm" ]
Mind training is a Intervention_Educational, children is a Participant_Age, autism : is a Outcome_Physical, Autism Spectrum Disorders ( ASD ) is a Participant_Condition, Theory of Mind ( ToM ) treatments is a Intervention_Educational, effectiveness is a Outcome_Other, ToM treatment is a Intervention_Educational, 8 - 13 year old children is a Participant_Age	47932_task0	Sentence: Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Condition, Intervention_Educational, Outcome_Physical, Participant_Age, Outcome_Other	[ "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Age", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills .	[ "Theory", "of", "Mind", "training", "in", "children", "with", "autism", ":", "a", "randomized", "controlled", "trial", ".", "Many", "children", "with", "Autism", "Spectrum", "Disorders", "(", "ASD", ")", "participate", "in", "social", "skills", "or", "Theory", "of", "Mind", "(", "ToM", ")", "treatments", ".", "However", ",", "few", "studies", "have", "shown", "evidence", "for", "their", "effectiveness", ".", "The", "current", "study", "used", "a", "randomized", "controlled", "design", "to", "test", "the", "effectiveness", "of", "a", "16-week", "ToM", "treatment", "in", "8", "-", "13", "year", "old", "children", "with", "ASD", "and", "normal", "IQs", "(", "n", "=", "40", ")", ".", "The", "results", "showed", "that", ",", "compared", "to", "controls", ",", "the", "treated", "children", "with", "ASD", "improved", "in", "their", "conceptual", "ToM", "skills", ",", "but", "their", "elementary", "understanding", ",", "self", "reported", "empathic", "skills", "or", "parent", "reported", "social", "behaviour", "did", "not", "improve", ".", "Despite", "the", "effects", "on", "conceptual", "understanding", ",", "the", "current", "study", "does", "not", "indicate", "strong", "evidence", "for", "the", "effectiveness", "of", "a", "ToM", "treatment", "on", "the", "daily", "life", "mindreading", "skills", "." ]	[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Outcome_Other", "Outcome_Physical" ]
Mind training is a Intervention_Educational, children is a Participant_Age, autism : is a Outcome_Physical, Autism Spectrum Disorders ( ASD ) is a Participant_Condition, Theory of Mind ( ToM ) treatments is a Intervention_Educational, effectiveness is a Outcome_Other, ToM treatment is a Intervention_Educational, 8 - 13 year old children is a Participant_Age	47932_task1	Sentence: Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills . Instructions: please typing these entity words according to sentence: Mind training, children, autism :, Autism Spectrum Disorders ( ASD ), Theory of Mind ( ToM ) treatments, effectiveness, ToM treatment, 8 - 13 year old children Options: Participant_Condition, Intervention_Educational, Outcome_Physical, Participant_Age, Outcome_Other	[ "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Age", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills .	[ "Theory", "of", "Mind", "training", "in", "children", "with", "autism", ":", "a", "randomized", "controlled", "trial", ".", "Many", "children", "with", "Autism", "Spectrum", "Disorders", "(", "ASD", ")", "participate", "in", "social", "skills", "or", "Theory", "of", "Mind", "(", "ToM", ")", "treatments", ".", "However", ",", "few", "studies", "have", "shown", "evidence", "for", "their", "effectiveness", ".", "The", "current", "study", "used", "a", "randomized", "controlled", "design", "to", "test", "the", "effectiveness", "of", "a", "16-week", "ToM", "treatment", "in", "8", "-", "13", "year", "old", "children", "with", "ASD", "and", "normal", "IQs", "(", "n", "=", "40", ")", ".", "The", "results", "showed", "that", ",", "compared", "to", "controls", ",", "the", "treated", "children", "with", "ASD", "improved", "in", "their", "conceptual", "ToM", "skills", ",", "but", "their", "elementary", "understanding", ",", "self", "reported", "empathic", "skills", "or", "parent", "reported", "social", "behaviour", "did", "not", "improve", ".", "Despite", "the", "effects", "on", "conceptual", "understanding", ",", "the", "current", "study", "does", "not", "indicate", "strong", "evidence", "for", "the", "effectiveness", "of", "a", "ToM", "treatment", "on", "the", "daily", "life", "mindreading", "skills", "." ]	[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Outcome_Other", "Outcome_Physical" ]
Mind training, children, autism :, Autism Spectrum Disorders ( ASD ), Theory of Mind ( ToM ) treatments, effectiveness, ToM treatment, 8 - 13 year old children	47932_task2	Sentence: Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Age", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "O", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills .	[ "Theory", "of", "Mind", "training", "in", "children", "with", "autism", ":", "a", "randomized", "controlled", "trial", ".", "Many", "children", "with", "Autism", "Spectrum", "Disorders", "(", "ASD", ")", "participate", "in", "social", "skills", "or", "Theory", "of", "Mind", "(", "ToM", ")", "treatments", ".", "However", ",", "few", "studies", "have", "shown", "evidence", "for", "their", "effectiveness", ".", "The", "current", "study", "used", "a", "randomized", "controlled", "design", "to", "test", "the", "effectiveness", "of", "a", "16-week", "ToM", "treatment", "in", "8", "-", "13", "year", "old", "children", "with", "ASD", "and", "normal", "IQs", "(", "n", "=", "40", ")", ".", "The", "results", "showed", "that", ",", "compared", "to", "controls", ",", "the", "treated", "children", "with", "ASD", "improved", "in", "their", "conceptual", "ToM", "skills", ",", "but", "their", "elementary", "understanding", ",", "self", "reported", "empathic", "skills", "or", "parent", "reported", "social", "behaviour", "did", "not", "improve", ".", "Despite", "the", "effects", "on", "conceptual", "understanding", ",", "the", "current", "study", "does", "not", "indicate", "strong", "evidence", "for", "the", "effectiveness", "of", "a", "ToM", "treatment", "on", "the", "daily", "life", "mindreading", "skills", "." ]	[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Outcome_Other", "Outcome_Physical" ]
Erbium is an umlsterm, laser is an umlsterm, sclerostomy is an umlsterm, glaucoma is an umlsterm, surgery is an umlsterm, date is an umlsterm, method is an umlsterm, trabeculectomy is an umlsterm, cause is an umlsterm, therapy is an umlsterm, postoperative is an umlsterm, bleb is an umlsterm, aim is an umlsterm, complication is an umlsterm	DerOpthalmologe.60930569.eng.abstr_task0	Sentence: Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication .	[ "Background", ":", "Erbium", "laser", "sclerostomy", "(", "ELS", ")", "ab", "externo", "is", "a", "minimally", "invasive", "addition", "to", "conventional", "fistulating", "glaucoma", "surgery", ".", "To", "date", ",", "the", "success", "rate", "of", "this", "method", "is", "lower", "than", "that", "of", "trabeculectomy", "or", "goniotrepanation", ".", "The", "chief", "cause", "of", "therapy", "failure", "is", "postoperative", "episcleral", "scarring", "of", "the", "bleb", ".", "It", "was", "the", "aim", "of", "the", "present", "study", "to", "decrease", "the", "occlusion", "rate", "of", "this", "complication", "." ]	[ "umlsterm" ]
Erbium is an umlsterm, laser is an umlsterm, sclerostomy is an umlsterm, glaucoma is an umlsterm, surgery is an umlsterm, date is an umlsterm, method is an umlsterm, trabeculectomy is an umlsterm, cause is an umlsterm, therapy is an umlsterm, postoperative is an umlsterm, bleb is an umlsterm, aim is an umlsterm, complication is an umlsterm	DerOpthalmologe.60930569.eng.abstr_task1	Sentence: Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication . Instructions: please typing these entity words according to sentence: Erbium, laser, sclerostomy, glaucoma, surgery, date, method, trabeculectomy, cause, therapy, postoperative, bleb, aim, complication Options: umlsterm	[ "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication .	[ "Background", ":", "Erbium", "laser", "sclerostomy", "(", "ELS", ")", "ab", "externo", "is", "a", "minimally", "invasive", "addition", "to", "conventional", "fistulating", "glaucoma", "surgery", ".", "To", "date", ",", "the", "success", "rate", "of", "this", "method", "is", "lower", "than", "that", "of", "trabeculectomy", "or", "goniotrepanation", ".", "The", "chief", "cause", "of", "therapy", "failure", "is", "postoperative", "episcleral", "scarring", "of", "the", "bleb", ".", "It", "was", "the", "aim", "of", "the", "present", "study", "to", "decrease", "the", "occlusion", "rate", "of", "this", "complication", "." ]	[ "umlsterm" ]
Erbium, laser, sclerostomy, glaucoma, surgery, date, method, trabeculectomy, cause, therapy, postoperative, bleb, aim, complication	DerOpthalmologe.60930569.eng.abstr_task2	Sentence: Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication .	[ "Background", ":", "Erbium", "laser", "sclerostomy", "(", "ELS", ")", "ab", "externo", "is", "a", "minimally", "invasive", "addition", "to", "conventional", "fistulating", "glaucoma", "surgery", ".", "To", "date", ",", "the", "success", "rate", "of", "this", "method", "is", "lower", "than", "that", "of", "trabeculectomy", "or", "goniotrepanation", ".", "The", "chief", "cause", "of", "therapy", "failure", "is", "postoperative", "episcleral", "scarring", "of", "the", "bleb", ".", "It", "was", "the", "aim", "of", "the", "present", "study", "to", "decrease", "the", "occlusion", "rate", "of", "this", "complication", "." ]	[ "umlsterm" ]
Gewebevertraeglichkeit is an umlsterm, Ratten is an umlsterm, in vitro is an umlsterm, Peritoneum is an umlsterm, Versuchstier is an umlsterm, Lavage is an umlsterm, Langzeitanwendung is an umlsterm, Peritonealspuelung is an umlsterm, Spuelung is an umlsterm, Ethanol is an umlsterm	DerChirurg.80690840.ger.abstr_task0	Sentence: Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika .	[ "Zusammenfassung", ".", "Als", "sensitive", "Screeningmethode", "zur", "Ermittlung", "der", "Gewebevertraeglichkeit", "lokaler", "Wundantiinfektiva", "eignet", "sich", "die", "Kultivierung", "von", "Peritonealexplantaten", "neonataler", "Ratten", "in", "vitro", "nach", "vorheriger", "Substanzeinwirkung", "zur", "Simulierung", "der", "Wundantiseptik", ".", "Es", "werden", "2", "Pruefmodelle", "unterschieden", ":", "(", "1", "separierte", "Peritonealexplantate", ")", "als", "Modell", "fuer", "chronische", "bzw", ".", "tiefe", "Wunden", "und", "(", "2", "Peritoneum", ")", "in", "situ", "am", "Versuchstier", "mit", "anschliessender", "Explantatgewinnung", "und", "-kultivierung", ".", "Unter", "Beruecksichtigung", "des", "aktuellen", "Wissensstandes", "lassen", "sich", "folgende", "Schlussfolgerungen", "zur", "Wundantiseptik", "ableiten", ":", "Lavasept", "ist", "0,1", "%", "ig", "als", "Wirkstoff", "der", "Wahl", "fuer", "tiefe", "bzw", ".", "chronische", "Wunden", ",", "zur", "Spuel", "-", "Saug", "-", "Drainage", "und", "zur", "antiinfektiven", "Lavage", "von", "Koerperhoehlen", "einschliesslich", "Bauchhoehle", "(", "0,05", "%", ")", "einzuordnen", ".", "Bei", "Langzeitanwendung", "(", ">", "6", "Std", ")", "ist", "auch", "Taurolidin", "antiseptisch", "effektiv", "und", "durch", "seine", "antitoxische", "Wirkung", "sowie", "fehlende", "Cytotoxizitaet", "speziell", "zur", "Peritonealspuelung", "praedestiniert", ".", "Betaisodona", "-", "Loesung", "ist", "fuer", "oberflaechliche", "kontaminierte", "Wunden", "geeignet", ",", "kann", "aber", "1", "10", ":", "verduennt", "auch", "zur", "kurzfristigen", "Spuelung", "tiefer", "Wunden", "einschliesslich", "Koerperhoehlen", "mit", "Ausnahme", "der", "Bauchhoehle", "angewendet", "werden", ".", "Ethanol", "verursacht", "keine", "Explantathemmung", "und", "hat", "daher", "nach", "wie", "vor", "seine", "Bedeutung", "in", "Wundantiseptika", "." ]	[ "umlsterm" ]
Gewebevertraeglichkeit is an umlsterm, Ratten is an umlsterm, in vitro is an umlsterm, Peritoneum is an umlsterm, Versuchstier is an umlsterm, Lavage is an umlsterm, Langzeitanwendung is an umlsterm, Peritonealspuelung is an umlsterm, Spuelung is an umlsterm, Ethanol is an umlsterm	DerChirurg.80690840.ger.abstr_task1	Sentence: Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika . Instructions: please typing these entity words according to sentence: Gewebevertraeglichkeit, Ratten, in vitro, Peritoneum, Versuchstier, Lavage, Langzeitanwendung, Peritonealspuelung, Spuelung, Ethanol Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika .	[ "Zusammenfassung", ".", "Als", "sensitive", "Screeningmethode", "zur", "Ermittlung", "der", "Gewebevertraeglichkeit", "lokaler", "Wundantiinfektiva", "eignet", "sich", "die", "Kultivierung", "von", "Peritonealexplantaten", "neonataler", "Ratten", "in", "vitro", "nach", "vorheriger", "Substanzeinwirkung", "zur", "Simulierung", "der", "Wundantiseptik", ".", "Es", "werden", "2", "Pruefmodelle", "unterschieden", ":", "(", "1", "separierte", "Peritonealexplantate", ")", "als", "Modell", "fuer", "chronische", "bzw", ".", "tiefe", "Wunden", "und", "(", "2", "Peritoneum", ")", "in", "situ", "am", "Versuchstier", "mit", "anschliessender", "Explantatgewinnung", "und", "-kultivierung", ".", "Unter", "Beruecksichtigung", "des", "aktuellen", "Wissensstandes", "lassen", "sich", "folgende", "Schlussfolgerungen", "zur", "Wundantiseptik", "ableiten", ":", "Lavasept", "ist", "0,1", "%", "ig", "als", "Wirkstoff", "der", "Wahl", "fuer", "tiefe", "bzw", ".", "chronische", "Wunden", ",", "zur", "Spuel", "-", "Saug", "-", "Drainage", "und", "zur", "antiinfektiven", "Lavage", "von", "Koerperhoehlen", "einschliesslich", "Bauchhoehle", "(", "0,05", "%", ")", "einzuordnen", ".", "Bei", "Langzeitanwendung", "(", ">", "6", "Std", ")", "ist", "auch", "Taurolidin", "antiseptisch", "effektiv", "und", "durch", "seine", "antitoxische", "Wirkung", "sowie", "fehlende", "Cytotoxizitaet", "speziell", "zur", "Peritonealspuelung", "praedestiniert", ".", "Betaisodona", "-", "Loesung", "ist", "fuer", "oberflaechliche", "kontaminierte", "Wunden", "geeignet", ",", "kann", "aber", "1", "10", ":", "verduennt", "auch", "zur", "kurzfristigen", "Spuelung", "tiefer", "Wunden", "einschliesslich", "Koerperhoehlen", "mit", "Ausnahme", "der", "Bauchhoehle", "angewendet", "werden", ".", "Ethanol", "verursacht", "keine", "Explantathemmung", "und", "hat", "daher", "nach", "wie", "vor", "seine", "Bedeutung", "in", "Wundantiseptika", "." ]	[ "umlsterm" ]
Gewebevertraeglichkeit, Ratten, in vitro, Peritoneum, Versuchstier, Lavage, Langzeitanwendung, Peritonealspuelung, Spuelung, Ethanol	DerChirurg.80690840.ger.abstr_task2	Sentence: Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika .	[ "Zusammenfassung", ".", "Als", "sensitive", "Screeningmethode", "zur", "Ermittlung", "der", "Gewebevertraeglichkeit", "lokaler", "Wundantiinfektiva", "eignet", "sich", "die", "Kultivierung", "von", "Peritonealexplantaten", "neonataler", "Ratten", "in", "vitro", "nach", "vorheriger", "Substanzeinwirkung", "zur", "Simulierung", "der", "Wundantiseptik", ".", "Es", "werden", "2", "Pruefmodelle", "unterschieden", ":", "(", "1", "separierte", "Peritonealexplantate", ")", "als", "Modell", "fuer", "chronische", "bzw", ".", "tiefe", "Wunden", "und", "(", "2", "Peritoneum", ")", "in", "situ", "am", "Versuchstier", "mit", "anschliessender", "Explantatgewinnung", "und", "-kultivierung", ".", "Unter", "Beruecksichtigung", "des", "aktuellen", "Wissensstandes", "lassen", "sich", "folgende", "Schlussfolgerungen", "zur", "Wundantiseptik", "ableiten", ":", "Lavasept", "ist", "0,1", "%", "ig", "als", "Wirkstoff", "der", "Wahl", "fuer", "tiefe", "bzw", ".", "chronische", "Wunden", ",", "zur", "Spuel", "-", "Saug", "-", "Drainage", "und", "zur", "antiinfektiven", "Lavage", "von", "Koerperhoehlen", "einschliesslich", "Bauchhoehle", "(", "0,05", "%", ")", "einzuordnen", ".", "Bei", "Langzeitanwendung", "(", ">", "6", "Std", ")", "ist", "auch", "Taurolidin", "antiseptisch", "effektiv", "und", "durch", "seine", "antitoxische", "Wirkung", "sowie", "fehlende", "Cytotoxizitaet", "speziell", "zur", "Peritonealspuelung", "praedestiniert", ".", "Betaisodona", "-", "Loesung", "ist", "fuer", "oberflaechliche", "kontaminierte", "Wunden", "geeignet", ",", "kann", "aber", "1", "10", ":", "verduennt", "auch", "zur", "kurzfristigen", "Spuelung", "tiefer", "Wunden", "einschliesslich", "Koerperhoehlen", "mit", "Ausnahme", "der", "Bauchhoehle", "angewendet", "werden", ".", "Ethanol", "verursacht", "keine", "Explantathemmung", "und", "hat", "daher", "nach", "wie", "vor", "seine", "Bedeutung", "in", "Wundantiseptika", "." ]	[ "umlsterm" ]
Zaire is an umlsterm, Aids is an umlsterm, CDC is an umlsterm, molluscum contagiosum infection is an umlsterm, cryptococcosis is an umlsterm, cryptosporidiosis is an umlsterm, molluscum contagiosum infection is an umlsterm, disease is an umlsterm, persons is an umlsterm, giant is an umlsterm, mollusca is an umlsterm, immunodeficiency is an umlsterm, T cell is an umlsterm, populations is an umlsterm, infection is an umlsterm, cryptococcosis is an umlsterm, differential diagnosis is an umlsterm, differential diagnoses is an umlsterm, histoplasmosis is an umlsterm, mycobacterial infections is an umlsterm, toxoplasmosis is an umlsterm, Pneumocystis carinii infection is an umlsterm	DerHautarzt.50460799.eng.abstr_task0	Sentence: A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection .	[ "A", "12-year", "-", "old", "girl", "from", "Zaire", "with", "Aids", "(", "CDC", ":", "P2", "D1", ")", "presented", "with", "a", "generalized", "molluscum", "contagiosum", "infection", ".", "She", "had", "suffered", "from", "systemic", "cryptococcosis", "and", "from", "cryptosporidiosis", "several", "months", "before", "admission", ".", "While", "molluscum", "contagiosum", "infection", "is", "usually", "a", "self", "-", "limiting", "disease", "in", "immunocompetent", "persons", ",", "a", "fulminant", "appearance", "and", "persistence", "of", "giant", "mollusca", "occurs", "with", "advanced", "immunodeficiency", ".", "Histological", "and", "immunohistological", "examinations", "showed", "a", "severe", "diminution", "of", "Langerhans", "and", "T", "cell", "populations", "that", "might", "enhance", "the", "dissemination", "of", "the", "infection", ".", "Molluscum", "-", "like", "lesions", "of", "cryptococci", "have", "been", "described", ",", "and", "cutaneous", "cryptococcosis", "is", "the", "main", "condition", "to", "be", "considered", "in", "the", "differential", "diagnosis", ".", "Further", "differential", "diagnoses", "should", "include", "American", "and", "African", "histoplasmosis", ",", "and", "the", "cutaneous", "manifestations", "of", "mycobacterial", "infections", ",", "of", "toxoplasmosis", "and", "of", "Pneumocystis", "carinii", "infection", "." ]	[ "umlsterm" ]
Zaire is an umlsterm, Aids is an umlsterm, CDC is an umlsterm, molluscum contagiosum infection is an umlsterm, cryptococcosis is an umlsterm, cryptosporidiosis is an umlsterm, molluscum contagiosum infection is an umlsterm, disease is an umlsterm, persons is an umlsterm, giant is an umlsterm, mollusca is an umlsterm, immunodeficiency is an umlsterm, T cell is an umlsterm, populations is an umlsterm, infection is an umlsterm, cryptococcosis is an umlsterm, differential diagnosis is an umlsterm, differential diagnoses is an umlsterm, histoplasmosis is an umlsterm, mycobacterial infections is an umlsterm, toxoplasmosis is an umlsterm, Pneumocystis carinii infection is an umlsterm	DerHautarzt.50460799.eng.abstr_task1	Sentence: A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection . Instructions: please typing these entity words according to sentence: Zaire, Aids, CDC, molluscum contagiosum infection, cryptococcosis, cryptosporidiosis, molluscum contagiosum infection, disease, persons, giant, mollusca, immunodeficiency, T cell, populations, infection, cryptococcosis, differential diagnosis, differential diagnoses, histoplasmosis, mycobacterial infections, toxoplasmosis, Pneumocystis carinii infection Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection .	[ "A", "12-year", "-", "old", "girl", "from", "Zaire", "with", "Aids", "(", "CDC", ":", "P2", "D1", ")", "presented", "with", "a", "generalized", "molluscum", "contagiosum", "infection", ".", "She", "had", "suffered", "from", "systemic", "cryptococcosis", "and", "from", "cryptosporidiosis", "several", "months", "before", "admission", ".", "While", "molluscum", "contagiosum", "infection", "is", "usually", "a", "self", "-", "limiting", "disease", "in", "immunocompetent", "persons", ",", "a", "fulminant", "appearance", "and", "persistence", "of", "giant", "mollusca", "occurs", "with", "advanced", "immunodeficiency", ".", "Histological", "and", "immunohistological", "examinations", "showed", "a", "severe", "diminution", "of", "Langerhans", "and", "T", "cell", "populations", "that", "might", "enhance", "the", "dissemination", "of", "the", "infection", ".", "Molluscum", "-", "like", "lesions", "of", "cryptococci", "have", "been", "described", ",", "and", "cutaneous", "cryptococcosis", "is", "the", "main", "condition", "to", "be", "considered", "in", "the", "differential", "diagnosis", ".", "Further", "differential", "diagnoses", "should", "include", "American", "and", "African", "histoplasmosis", ",", "and", "the", "cutaneous", "manifestations", "of", "mycobacterial", "infections", ",", "of", "toxoplasmosis", "and", "of", "Pneumocystis", "carinii", "infection", "." ]	[ "umlsterm" ]
Zaire, Aids, CDC, molluscum contagiosum infection, cryptococcosis, cryptosporidiosis, molluscum contagiosum infection, disease, persons, giant, mollusca, immunodeficiency, T cell, populations, infection, cryptococcosis, differential diagnosis, differential diagnoses, histoplasmosis, mycobacterial infections, toxoplasmosis, Pneumocystis carinii infection	DerHautarzt.50460799.eng.abstr_task2	Sentence: A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection .	[ "A", "12-year", "-", "old", "girl", "from", "Zaire", "with", "Aids", "(", "CDC", ":", "P2", "D1", ")", "presented", "with", "a", "generalized", "molluscum", "contagiosum", "infection", ".", "She", "had", "suffered", "from", "systemic", "cryptococcosis", "and", "from", "cryptosporidiosis", "several", "months", "before", "admission", ".", "While", "molluscum", "contagiosum", "infection", "is", "usually", "a", "self", "-", "limiting", "disease", "in", "immunocompetent", "persons", ",", "a", "fulminant", "appearance", "and", "persistence", "of", "giant", "mollusca", "occurs", "with", "advanced", "immunodeficiency", ".", "Histological", "and", "immunohistological", "examinations", "showed", "a", "severe", "diminution", "of", "Langerhans", "and", "T", "cell", "populations", "that", "might", "enhance", "the", "dissemination", "of", "the", "infection", ".", "Molluscum", "-", "like", "lesions", "of", "cryptococci", "have", "been", "described", ",", "and", "cutaneous", "cryptococcosis", "is", "the", "main", "condition", "to", "be", "considered", "in", "the", "differential", "diagnosis", ".", "Further", "differential", "diagnoses", "should", "include", "American", "and", "African", "histoplasmosis", ",", "and", "the", "cutaneous", "manifestations", "of", "mycobacterial", "infections", ",", "of", "toxoplasmosis", "and", "of", "Pneumocystis", "carinii", "infection", "." ]	[ "umlsterm" ]
Rb is a protein, p107 is a protein, p130 is a protein, E2F target promoters is a DNA	1.0alpha7.train.60_task0	Sentence: E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA, protein	[ "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O" ]	E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49).	[ "E2Fs", "bind", "directly", "to", "Rb", ",", "p107", ",", "and", "p130", ",", "and", "we", "have", "previously", "shown", "that", "these", "proteins", "are", "components", "of", "the", "transcription", "complexes", "formed", "on", "E2F", "target", "promoters", "in", "vivo", "(", "49", ")", "." ]	[ "DNA", "protein", "protein-family" ]
Rb is a protein, p107 is a protein, p130 is a protein, E2F target promoters is a DNA	1.0alpha7.train.60_task1	Sentence: E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49). Instructions: please typing these entity words according to sentence: Rb, p107, p130, E2F target promoters Options: DNA, protein	[ "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O" ]	E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49).	[ "E2Fs", "bind", "directly", "to", "Rb", ",", "p107", ",", "and", "p130", ",", "and", "we", "have", "previously", "shown", "that", "these", "proteins", "are", "components", "of", "the", "transcription", "complexes", "formed", "on", "E2F", "target", "promoters", "in", "vivo", "(", "49", ")", "." ]	[ "DNA", "protein", "protein-family" ]
Rb, p107, p130, E2F target promoters	1.0alpha7.train.60_task2	Sentence: E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49). Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O" ]	E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49).	[ "E2Fs", "bind", "directly", "to", "Rb", ",", "p107", ",", "and", "p130", ",", "and", "we", "have", "previously", "shown", "that", "these", "proteins", "are", "components", "of", "the", "transcription", "complexes", "formed", "on", "E2F", "target", "promoters", "in", "vivo", "(", "49", ")", "." ]	[ "DNA", "protein", "protein-family" ]
repressor / activator is an other_name, NF - E1 is a protein_molecule, YY-1 is a protein_molecule, delta is a protein_molecule, immunoglobulin kappa 3 ' enhancer is a DNA_domain_or_region, immunoglobulin heavy - chain mu E1 site is a DNA_domain_or_region	91080_task0	Sentence: Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region, protein_molecule, other_name	[ "O", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]	Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.	[ "Isolation", "of", "a", "candidate", "repressor", "/", "activator", ",", "NF", "-", "E1", "(", "YY-1", ",", "delta", ")", ",", "that", "binds", "to", "the", "immunoglobulin", "kappa", "3", "'", "enhancer", "and", "the", "immunoglobulin", "heavy", "-", "chain", "mu", "E1", "site", "." ]	[ "DNA_domain_or_region", "protein_family_or_group", "other_name", "protein_molecule", "DNA_molecule", "protein_N/A", "DNA_family_or_group" ]
repressor / activator is an other_name, NF - E1 is a protein_molecule, YY-1 is a protein_molecule, delta is a protein_molecule, immunoglobulin kappa 3 ' enhancer is a DNA_domain_or_region, immunoglobulin heavy - chain mu E1 site is a DNA_domain_or_region	91080_task1	Sentence: Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. Instructions: please typing these entity words according to sentence: repressor / activator, NF - E1, YY-1, delta, immunoglobulin kappa 3 ' enhancer, immunoglobulin heavy - chain mu E1 site Options: DNA_domain_or_region, protein_molecule, other_name	[ "O", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]	Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.	[ "Isolation", "of", "a", "candidate", "repressor", "/", "activator", ",", "NF", "-", "E1", "(", "YY-1", ",", "delta", ")", ",", "that", "binds", "to", "the", "immunoglobulin", "kappa", "3", "'", "enhancer", "and", "the", "immunoglobulin", "heavy", "-", "chain", "mu", "E1", "site", "." ]	[ "DNA_domain_or_region", "protein_family_or_group", "other_name", "protein_molecule", "DNA_molecule", "protein_N/A", "DNA_family_or_group" ]

atopic dermatitis - like skin lesions is a DISEASE, Atopic dermatitis is a DISEASE, AD is a DISEASE, chronic inflammatory skin disease is a DISEASE, skin inflammation is a DISEASE, AD - like skin lesions is a DISEASE, AD - like skin lesions is a DISEASE, ear swelling is a DISEASE, skin inflammation is a DISEASE, AD is a DISEASE, inflammatory skin diseases is a DISEASE

example-207_task1

Sentence: Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice. Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-alpha expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases. Instructions: please typing these entity words according to sentence: atopic dermatitis - like skin lesions, Atopic dermatitis, AD, chronic inflammatory skin disease, skin inflammation, AD - like skin lesions, AD - like skin lesions, ear swelling, skin inflammation, AD, inflammatory skin diseases Options: DISEASE

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Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice. Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-alpha expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases.

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[ "DISEASE" ]

atopic dermatitis - like skin lesions, Atopic dermatitis, AD, chronic inflammatory skin disease, skin inflammation, AD - like skin lesions, AD - like skin lesions, ear swelling, skin inflammation, AD, inflammatory skin diseases

example-207_task2

Sentence: Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice. Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-alpha expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases. Instructions: please extract entity words from the input sentence

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Inhibition of atopic dermatitis-like skin lesions by topical application of a novel ceramide derivative, K6PC-9p, in NC/Nga mice. Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) is a synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective in atopic patients. In this study, we examined the effect of topical application of K6PC-9p on skin inflammation and AD-like skin lesions in mouse models. K6PC-9p dose-dependently inhibited phorbol ester-induced increase in ear thickness in BALB/c mice. Moreover, topical application of K6PC-9p suppressed dust mite extract-induced AD-like skin lesions in NC/Nga mice. Histopathological analysis revealed that both ear swelling and leucocyte infiltration were suppressed by K6PC-9p treatment. K6PC-9p also suppressed IL-4 and TNF-alpha expression in the ears and mast cell infiltration into the ears in NC/Nga mice. Further study demonstrated that K6PC-9p inhibited ConA-induced IL-4 secretion and LPS-induced macrophage activation. Taken together, our results showed that topical application of K6PC-9p exerts beneficial effects in animal model of skin inflammation and AD, suggesting that K6PC-9p might be a promising topical agent for the treatment of inflammatory skin diseases.

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[ "DISEASE" ]

children is a Participant_Age, autism is a Participant_Condition, social - interaction - based therapy is a Intervention_Psychological, effectiveness is a Outcome_Other, MEHRIT , a social - interaction - based intervention is a Intervention_Educational, communicative language acts is a Outcome_Mental, outperformed is a Outcome_Other, MLUm , number of utterances produced , and various speech act categories . is a Outcome_Mental, functional language measures is a Outcome_Other, children ' s use of language during parent - child interactions is a Outcome_Other

67834_task0

Sentence: Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Psychological, Participant_Condition, Intervention_Educational, Participant_Age, Outcome_Other, Outcome_Mental

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Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions .

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[ "Outcome_Mental", "Outcome_Other", "Intervention_Educational", "Intervention_Psychological", "Participant_Age", "Participant_Condition" ]

children is a Participant_Age, autism is a Participant_Condition, social - interaction - based therapy is a Intervention_Psychological, effectiveness is a Outcome_Other, MEHRIT , a social - interaction - based intervention is a Intervention_Educational, communicative language acts is a Outcome_Mental, outperformed is a Outcome_Other, MLUm , number of utterances produced , and various speech act categories . is a Outcome_Mental, functional language measures is a Outcome_Other, children ' s use of language during parent - child interactions is a Outcome_Other

67834_task1

Sentence: Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions . Instructions: please typing these entity words according to sentence: children, autism, social - interaction - based therapy, effectiveness, MEHRIT , a social - interaction - based intervention, communicative language acts, outperformed, MLUm , number of utterances produced , and various speech act categories ., functional language measures, children ' s use of language during parent - child interactions Options: Intervention_Psychological, Participant_Condition, Intervention_Educational, Participant_Age, Outcome_Other, Outcome_Mental

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Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions .

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[ "Outcome_Mental", "Outcome_Other", "Intervention_Educational", "Intervention_Psychological", "Participant_Age", "Participant_Condition" ]

children, autism, social - interaction - based therapy, effectiveness, MEHRIT , a social - interaction - based intervention, communicative language acts, outperformed, MLUm , number of utterances produced , and various speech act categories ., functional language measures, children ' s use of language during parent - child interactions

67834_task2

Sentence: Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-Participant_Age", "O", "B-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O" ]

Measuring and supporting language function for children with autism : evidence from a randomized control trial of a social-interaction-based therapy . In a report of the effectiveness of MEHRIT , a social-interaction-based intervention for autism , Casenhiser et al . ( Autism 17 ( 2 ) :220-241 , 2013 ) failed to find a significant advantage for language development in the treatment group using standardized language assessments . We present the results from a re-analysis of their results to illustrate the importance of measuring communicative language acts ( formally called " speech acts " ) . Reanalysis confirmed that children in the MEHRIT group outperformed the community treatment group on measures of MLUm , number of utterances produced , and various speech act categories . The study underscores the importance of functional language measures in guiding and evaluating treatment for children with autism , and suggests that MEHRIT is effective in improving children 's use of language during parent-child interactions .

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[ "Outcome_Mental", "Outcome_Other", "Intervention_Educational", "Intervention_Psychological", "Participant_Age", "Participant_Condition" ]

vitamin A - fortified coconut cooking oil is a Intervention_Pharmacological, serum retinol concentration is a Outcome_Physical, Filipino is a Participant_Condition, 4 - 7 years old is a Participant_Age, 542 is a Participant_Sample-size, 4 to 7 is a Participant_Age, vitamin A - fortified cooking oil is a Intervention_Pharmacological, unfortified cooking oil ration is a Intervention_Pharmacological, without cooking oil ration is a Intervention_Control, prevention is a Outcome_Other, control is a Outcome_Other

20685_task0

Sentence: The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other

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The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency .

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[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Age", "Outcome_Other", "Participant_Sample-size" ]

vitamin A - fortified coconut cooking oil is a Intervention_Pharmacological, serum retinol concentration is a Outcome_Physical, Filipino is a Participant_Condition, 4 - 7 years old is a Participant_Age, 542 is a Participant_Sample-size, 4 to 7 is a Participant_Age, vitamin A - fortified cooking oil is a Intervention_Pharmacological, unfortified cooking oil ration is a Intervention_Pharmacological, without cooking oil ration is a Intervention_Control, prevention is a Outcome_Other, control is a Outcome_Other

20685_task1

Sentence: The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency . Instructions: please typing these entity words according to sentence: vitamin A - fortified coconut cooking oil, serum retinol concentration, Filipino, 4 - 7 years old, 542, 4 to 7, vitamin A - fortified cooking oil, unfortified cooking oil ration, without cooking oil ration, prevention, control Options: Intervention_Pharmacological, Participant_Condition, Intervention_Control, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other

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The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency .

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[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Age", "Outcome_Other", "Participant_Sample-size" ]

vitamin A - fortified coconut cooking oil, serum retinol concentration, Filipino, 4 - 7 years old, 542, 4 to 7, vitamin A - fortified cooking oil, unfortified cooking oil ration, without cooking oil ration, prevention, control

20685_task2

Sentence: The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency . Instructions: please extract entity words from the input sentence

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The effect of vitamin A-fortified coconut cooking oil on the serum retinol concentration of Filipino children 4-7 years old . A 6-month intervention trial was conducted among 542 Filipino children aged 4 to 7 years to determine the effect of vitamin A-fortified coconut cooking oil intake on their vitamin A status and to identify factors that influence this . Children were randomly assigned to the Experimental group , with vitamin A-fortified cooking oil ration ; to Control-1 group with unfortified cooking oil ration ; and to Control-2 group without cooking oil ration . In all groups , children 's serum retinol concentration improved . Relative change in serum retinol concentration was significantly higher among the Experimental group , with one-third of total vitamin A intake coming from vitamin A-fortified cooking oil intake , than in the Control groups , with more than half of intake from other vitamin A-rich foods . Determinants of post-intervention serum retinol concentration included baseline serum retinol concentration , caregiver 's education , receipt of high-dose vitamin A capsule , interaction between consumption of vitamin A-fortified cooking oil and of other vitamin A-rich foods , and between households purchasing cooking oil and food expenditure . Intake of vitamin A-fortified cooking oil combined with vitamin A-rich foods was necessary to increase serum retinol concentration . It is recommended to vigorously promote the consumption of vitamin A-fortified cooking oil together with other vitamin A-rich sources to sustain the prevention and control of vitamin A deficiency .

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[ "Intervention_Pharmacological", "Outcome_Physical", "Participant_Condition", "Intervention_Control", "Participant_Age", "Outcome_Other", "Participant_Sample-size" ]

lymphoma is an umlsterm, malignant lymphoma is an umlsterm, thymus is an umlsterm, spleen is an umlsterm, Waldeyer 's is an umlsterm, appendix is an umlsterm, secondary is an umlsterm, lymphoproliferative disease is an umlsterm, lymphomas is an umlsterm, non - Hodgkin lymphomas is an umlsterm, Hodgkin 's is an umlsterm, disease is an umlsterm, NHL is an umlsterm, malignant is an umlsterm, forms is an umlsterm, MALT lymphomas is an umlsterm, growth is an umlsterm, pseudolymphomas is an umlsterm, tumor is an umlsterm, growth is an umlsterm, time is an umlsterm, Lymphoma is an umlsterm, classification is an umlsterm, incidence is an umlsterm, classification is an umlsterm, Secondary is an umlsterm, NHL is an umlsterm, disease is an umlsterm, lymphomas is an umlsterm, Secondary is an umlsterm, AIDS is an umlsterm, patients is an umlsterm, AIDS - related lymphoma is an umlsterm, imaging is an umlsterm, lymphoma is an umlsterm

DerRadiologe.70370027.eng.abstr_task0

Sentence: Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region .

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[ "umlsterm" ]

lymphoma is an umlsterm, malignant lymphoma is an umlsterm, thymus is an umlsterm, spleen is an umlsterm, Waldeyer 's is an umlsterm, appendix is an umlsterm, secondary is an umlsterm, lymphoproliferative disease is an umlsterm, lymphomas is an umlsterm, non - Hodgkin lymphomas is an umlsterm, Hodgkin 's is an umlsterm, disease is an umlsterm, NHL is an umlsterm, malignant is an umlsterm, forms is an umlsterm, MALT lymphomas is an umlsterm, growth is an umlsterm, pseudolymphomas is an umlsterm, tumor is an umlsterm, growth is an umlsterm, time is an umlsterm, Lymphoma is an umlsterm, classification is an umlsterm, incidence is an umlsterm, classification is an umlsterm, Secondary is an umlsterm, NHL is an umlsterm, disease is an umlsterm, lymphomas is an umlsterm, Secondary is an umlsterm, AIDS is an umlsterm, patients is an umlsterm, AIDS - related lymphoma is an umlsterm, imaging is an umlsterm, lymphoma is an umlsterm

DerRadiologe.70370027.eng.abstr_task1

Sentence: Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region . Instructions: please typing these entity words according to sentence: lymphoma, malignant lymphoma, thymus, spleen, Waldeyer 's, appendix, secondary, lymphoproliferative disease, lymphomas, non - Hodgkin lymphomas, Hodgkin 's, disease, NHL, malignant, forms, MALT lymphomas, growth, pseudolymphomas, tumor, growth, time, Lymphoma, classification, incidence, classification, Secondary, NHL, disease, lymphomas, Secondary, AIDS, patients, AIDS - related lymphoma, imaging, lymphoma Options: umlsterm

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Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region .

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[ "umlsterm" ]

lymphoma, malignant lymphoma, thymus, spleen, Waldeyer 's, appendix, secondary, lymphoproliferative disease, lymphomas, non - Hodgkin lymphomas, Hodgkin 's, disease, NHL, malignant, forms, MALT lymphomas, growth, pseudolymphomas, tumor, growth, time, Lymphoma, classification, incidence, classification, Secondary, NHL, disease, lymphomas, Secondary, AIDS, patients, AIDS - related lymphoma, imaging, lymphoma

DerRadiologe.70370027.eng.abstr_task2

Sentence: Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region . Instructions: please extract entity words from the input sentence

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Primary extranodal lymphoma manifestation in the narrow sense is the term used to define the primary organ manifestation of a malignant lymphoma , excluding the thymus , spleen , Waldeyer's tonsillar ring , the appendix and Peyer's patches . However , in the clinical routine the term is also used for the secondary organ manifestation of underlying lymphoproliferative disease . Primary extranodal lymphomas are mainly non-Hodgkin lymphomas ; there is primary extranodal manifestation of Hodgkin's disease in only about 1 % of the cases . Among the extranodal NHL , the highly malignant forms predominate . A major exception is MALT lymphomas , which mainly show low slow growth . In the past , they were considered to be pseudolymphomas because of their slow and localized tumor growth . They were included as an entity of their own for the first time in the Revised European American Lymphoma ( REAL ) classification of 1994. The incidence data vary between 10 % and 25 % for primary extranodal manifestation . The major reason for this is the difference in extranodal regions because of classification . Secondary organ involvment of an NHL occurs in up to 40 % of the cases in the long-term course of the disease in primary nodal lymphomas . Secondary organ involvment is frequently diagnosed in AIDS patients who develop an AIDS-related lymphoma ( 85 % of cases ) . The following contribution reports on the radiological imaging of extranodal lymphoma manifestation in the thoracoabdominal region .

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[ "umlsterm" ]

etiology is an umlsterm, patients is an umlsterm, accident is an umlsterm, symptoms is an umlsterm, range of motion is an umlsterm, spine is an umlsterm, recognition is an umlsterm, surgery is an umlsterm, contrast is an umlsterm, treatment is an umlsterm, patients is an umlsterm, regression is an umlsterm, symptoms is an umlsterm, patients is an umlsterm, range of motion is an umlsterm, spine is an umlsterm, pain is an umlsterm, patients is an umlsterm, surgical treatment is an umlsterm, complications is an umlsterm

DerUnfallchirurg.81010100.eng.abstr_task0

Sentence: The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications .

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[ "umlsterm" ]

etiology is an umlsterm, patients is an umlsterm, accident is an umlsterm, symptoms is an umlsterm, range of motion is an umlsterm, spine is an umlsterm, recognition is an umlsterm, surgery is an umlsterm, contrast is an umlsterm, treatment is an umlsterm, patients is an umlsterm, regression is an umlsterm, symptoms is an umlsterm, patients is an umlsterm, range of motion is an umlsterm, spine is an umlsterm, pain is an umlsterm, patients is an umlsterm, surgical treatment is an umlsterm, complications is an umlsterm

DerUnfallchirurg.81010100.eng.abstr_task1

Sentence: The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications . Instructions: please typing these entity words according to sentence: etiology, patients, accident, symptoms, range of motion, spine, recognition, surgery, contrast, treatment, patients, regression, symptoms, patients, range of motion, spine, pain, patients, surgical treatment, complications Options: umlsterm

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications .

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[ "umlsterm" ]

etiology, patients, accident, symptoms, range of motion, spine, recognition, surgery, contrast, treatment, patients, regression, symptoms, patients, range of motion, spine, pain, patients, surgical treatment, complications

DerUnfallchirurg.81010100.eng.abstr_task2

Sentence: The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications . Instructions: please extract entity words from the input sentence

[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

The etiology of os odontoideum is still controversial . In most patients , it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine . Upon recognition of the os odontoideum , it is unknown whether or not immediate surgery is beneficial . This is in contrast to an " unstable " os odontoideum , which could result in atlantoaxial instability or compression of the myelon . In this study , we present the results of our treatment of four patients with an unstable os odontoideum . In all four cases , a C1-2 fusion was performed ( 3 x Magerl/Seemann , 1 Gallie-Brooks ) . Postoperatively , we found a complete regression of neurological symptoms in three patients and one was significantly improved . The range of motion of the cervical spine was free of pain in all patients . As a result , we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications .

[ "The", "etiology", "of", "os", "odontoideum", "is", "still", "controversial", ".", "In", "most", "patients", ",", "it", "is", "found", "by", "accident", "because", "of", "neurological", "symptoms", "and", "/", "or", "painful", "range", "of", "motion", "of", "the", "cervical", "spine", ".", "Upon", "recognition", "of", "the", "os", "odontoideum", ",", "it", "is", "unknown", "whether", "or", "not", "immediate", "surgery", "is", "beneficial", ".", "This", "is", "in", "contrast", "to", "an", "\"", "unstable", "\"", "os", "odontoideum", ",", "which", "could", "result", "in", "atlantoaxial", "instability", "or", "compression", "of", "the", "myelon", ".", "In", "this", "study", ",", "we", "present", "the", "results", "of", "our", "treatment", "of", "four", "patients", "with", "an", "unstable", "os", "odontoideum", ".", "In", "all", "four", "cases", ",", "a", "C1", "-", "2", "fusion", "was", "performed", "(", "3", "x", "Magerl", "/", "Seemann", ",", "1", "Gallie", "-", "Brooks", ")", ".", "Postoperatively", ",", "we", "found", "a", "complete", "regression", "of", "neurological", "symptoms", "in", "three", "patients", "and", "one", "was", "significantly", "improved", ".", "The", "range", "of", "motion", "of", "the", "cervical", "spine", "was", "free", "of", "pain", "in", "all", "patients", ".", "As", "a", "result", ",", "we", "strongly", "support", "immediate", "surgical", "treatment", "of", "an", "unstable", "os", "odontoideum", "in", "order", "to", "prevent", "severe", "and", "life", "-", "threatening", "neurological", "complications", "." ]

[ "umlsterm" ]

JNK is a protein, SAPK is a protein, MEKK1 is a protein

1.0alpha7.train.121_task0

Sentence: JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein

[ "B-protein", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]

JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro

[ "JNK", "/", "SAPK", "Binds", "and", "Phosphorylates", "a", "MEKK1", "Fragment", "In", "Vitro" ]

[ "protein" ]

JNK is a protein, SAPK is a protein, MEKK1 is a protein

1.0alpha7.train.121_task1

Sentence: JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro Instructions: please typing these entity words according to sentence: JNK, SAPK, MEKK1 Options: protein

[ "B-protein", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]

JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro

[ "JNK", "/", "SAPK", "Binds", "and", "Phosphorylates", "a", "MEKK1", "Fragment", "In", "Vitro" ]

[ "protein" ]

JNK, SAPK, MEKK1

1.0alpha7.train.121_task2

Sentence: JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro Instructions: please extract entity words from the input sentence

[ "B-protein", "O", "B-protein", "O", "O", "O", "O", "B-protein", "O", "O", "O" ]

JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro

[ "JNK", "/", "SAPK", "Binds", "and", "Phosphorylates", "a", "MEKK1", "Fragment", "In", "Vitro" ]

[ "protein" ]

glutaminase is a GENE-N, synthase is a GENE-N, glutamate is a CHEMICAL

17373776_task0

Sentence: Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL

[ "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain.

[ "Activation", "and", "coupling", "of", "the", "glutaminase", "and", "synthase", "reaction", "of", "glutamate", "synthase", "is", "mediated", "by", "E1013", "of", "the", "ferredoxin", "-", "dependent", "enzyme", ",", "belonging", "to", "loop", "4", "of", "the", "synthase", "domain", "." ]

[ "GENE-N", "CHEMICAL" ]

glutaminase is a GENE-N, synthase is a GENE-N, glutamate is a CHEMICAL

17373776_task1

Sentence: Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain. Instructions: please typing these entity words according to sentence: glutaminase, synthase, glutamate Options: GENE-N, CHEMICAL

[ "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain.

[ "Activation", "and", "coupling", "of", "the", "glutaminase", "and", "synthase", "reaction", "of", "glutamate", "synthase", "is", "mediated", "by", "E1013", "of", "the", "ferredoxin", "-", "dependent", "enzyme", ",", "belonging", "to", "loop", "4", "of", "the", "synthase", "domain", "." ]

[ "GENE-N", "CHEMICAL" ]

glutaminase, synthase, glutamate

17373776_task2

Sentence: Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "B-GENE-N", "O", "B-GENE-N", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Activation and coupling of the glutaminase and synthase reaction of glutamate synthase is mediated by E1013 of the ferredoxin-dependent enzyme, belonging to loop 4 of the synthase domain.

[ "Activation", "and", "coupling", "of", "the", "glutaminase", "and", "synthase", "reaction", "of", "glutamate", "synthase", "is", "mediated", "by", "E1013", "of", "the", "ferredoxin", "-", "dependent", "enzyme", ",", "belonging", "to", "loop", "4", "of", "the", "synthase", "domain", "." ]

[ "GENE-N", "CHEMICAL" ]

activator protein ( AP)-1 is a Entity, nuclear factor - kappaB is a Entity, CD28 is a Protein, acidic sphingomyelinase is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, IL-2 is a Protein, B7 is a Protein, activator protein-1 ( AP-1 ) is a Entity, nuclear factor - kappaB ( NF - kappaB ) complexes is a Entity, CD28 is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, IL-2 is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, acidic sphingomyelinase is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, AP-1 is a Entity, acidic sphingomyelinase is a Protein

75_task0

Sentence: Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals. A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

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Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals. A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways.

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[ "Entity", "Protein" ]

activator protein ( AP)-1 is a Entity, nuclear factor - kappaB is a Entity, CD28 is a Protein, acidic sphingomyelinase is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, CD28 is a Protein, IL-2 is a Protein, B7 is a Protein, activator protein-1 ( AP-1 ) is a Entity, nuclear factor - kappaB ( NF - kappaB ) complexes is a Entity, CD28 is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, IL-2 is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, acidic sphingomyelinase is a Protein, AP-1 is a Entity, NF - kappaB is a Entity, AP-1 is a Entity, acidic sphingomyelinase is a Protein

75_task1

Sentence: Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals. A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways. Instructions: please typing these entity words according to sentence: activator protein ( AP)-1, nuclear factor - kappaB, CD28, acidic sphingomyelinase, CD28, CD28, CD28, CD28, CD28, CD28, IL-2, B7, activator protein-1 ( AP-1 ), nuclear factor - kappaB ( NF - kappaB ) complexes, CD28, AP-1, NF - kappaB, IL-2, AP-1, NF - kappaB, acidic sphingomyelinase, AP-1, NF - kappaB, AP-1, acidic sphingomyelinase Options: Entity, Protein

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Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals. A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways.

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[ "Entity", "Protein" ]

activator protein ( AP)-1, nuclear factor - kappaB, CD28, acidic sphingomyelinase, CD28, CD28, CD28, CD28, CD28, CD28, IL-2, B7, activator protein-1 ( AP-1 ), nuclear factor - kappaB ( NF - kappaB ) complexes, CD28, AP-1, NF - kappaB, IL-2, AP-1, NF - kappaB, acidic sphingomyelinase, AP-1, NF - kappaB, AP-1, acidic sphingomyelinase

75_task2

Sentence: Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals. A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways. Instructions: please extract entity words from the input sentence

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Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals. A major obstacle in understanding the signaling events that follow CD28 receptor ligation arises from the fact that CD28 acts as a costimulus to TCR engagement, making it difficult to assess the relative contribution of CD28 signals as distinct from those of the TCR. To overcome this problem, we have exploited the observation that activated human T cell blasts can be stimulated via the CD28 surface molecule in the absence of antigenic challenge; thus, we have been able to observe the response of normal T cells to CD28 activation in isolation. Using this system, we observed that CD28 stimulation by B7-transfected CHO cells induced a proliferative response in T cells that was not accompanied by measurable IL-2 production. However, subsequent analysis of transcription factor generation revealed that B7 stimulation induced both activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) complexes, but not NF-AT. In contrast, engagement of the TCR by class II MHC/superantigen, either with or without CD28 ligation, resulted in the induction of NF-AT, AP-1, and NF-kappaB as well as IL-2 production. Using selective inhibitors, we investigated the signaling pathways involved in the CD28-mediated induction of AP-1 and NF-kappaB. This revealed that NF-kappaB generation was sensitive to chloroquine, an inhibitor of acidic sphingomyelinase, but not to the phosphatidylinositol 3-kinase inhibitor, wortmannin. In contrast, AP-1 generation was inhibited by wortmannin and was also variably sensitive to chloroquine. These data suggest that in activated normal T cells, CD28-derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation, and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase-linked pathways.

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[ "Entity", "Protein" ]

Knochentumor is an umlsterm, Patienten is an umlsterm, Lebensdekade is an umlsterm, Epiphysen is an umlsterm, Femurkopf is an umlsterm, Radiologisch is an umlsterm, Tumorzellen is an umlsterm, Zytoplasma is an umlsterm, Beobachtungen is an umlsterm, Knochentumor - Registers is an umlsterm, Altersverteilung is an umlsterm, radiologischen is an umlsterm, Lebensdekade is an umlsterm, Femur is an umlsterm, Os ilium is an umlsterm, Hand is an umlsterm, Osteosarkom is an umlsterm, Chondrosarkom is an umlsterm, Epiphyse is an umlsterm, Skeletts is an umlsterm, Tumors is an umlsterm, Diagnosefindung is an umlsterm

DerPathologe.00210449.ger.abstr_task0

Sentence: Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung .

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[ "umlsterm" ]

Knochentumor is an umlsterm, Patienten is an umlsterm, Lebensdekade is an umlsterm, Epiphysen is an umlsterm, Femurkopf is an umlsterm, Radiologisch is an umlsterm, Tumorzellen is an umlsterm, Zytoplasma is an umlsterm, Beobachtungen is an umlsterm, Knochentumor - Registers is an umlsterm, Altersverteilung is an umlsterm, radiologischen is an umlsterm, Lebensdekade is an umlsterm, Femur is an umlsterm, Os ilium is an umlsterm, Hand is an umlsterm, Osteosarkom is an umlsterm, Chondrosarkom is an umlsterm, Epiphyse is an umlsterm, Skeletts is an umlsterm, Tumors is an umlsterm, Diagnosefindung is an umlsterm

DerPathologe.00210449.ger.abstr_task1

Sentence: Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung . Instructions: please typing these entity words according to sentence: Knochentumor, Patienten, Lebensdekade, Epiphysen, Femurkopf, Radiologisch, Tumorzellen, Zytoplasma, Beobachtungen, Knochentumor - Registers, Altersverteilung, radiologischen, Lebensdekade, Femur, Os ilium, Hand, Osteosarkom, Chondrosarkom, Epiphyse, Skeletts, Tumors, Diagnosefindung Options: umlsterm

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Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung .

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[ "umlsterm" ]

Knochentumor, Patienten, Lebensdekade, Epiphysen, Femurkopf, Radiologisch, Tumorzellen, Zytoplasma, Beobachtungen, Knochentumor - Registers, Altersverteilung, radiologischen, Lebensdekade, Femur, Os ilium, Hand, Osteosarkom, Chondrosarkom, Epiphyse, Skeletts, Tumors, Diagnosefindung

DerPathologe.00210449.ger.abstr_task2

Sentence: Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung . Instructions: please extract entity words from the input sentence

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Das Klarzellchondrosarkom ist ein seltener niedrigmaligner Knochentumor . Betroffen sind v. a. Patienten in der 3. und 4. Lebensdekade . Bevorzugte Lokalisation sind die Epiphysen langer Roehrenknochen , insbesondere der Femurkopf . Radiologisch imponiert es meist als eine epiphysaer gelegene , scharf begrenzte lytische Laesion . Histologisch charakteristisch sind die grossen Tumorzellen mit deutlichen Zellgrenzen und einem hellen Zytoplasma . Daneben finden sich auch Areale mit dem histologischen Bild eines konventionellen Chondrosarkoms sowie unterschiedlich breite , z . T. mineralisierte trabekulaere Osteoidformationen . Anhand von 16 Faellen mit Klarzellchondrosarkom werden die Erfahrungen und Beobachtungen des Hamburger Knochentumor-Registers dargestellt . Die Faelle wurden nach Altersverteilung , Lokalisation sowie radiologischen und pathomorphologischen Kriterien untersucht . Das Hauptmanifestationsalter lag innerhalb der 5.-7. Lebensdekade . Das proximale Femur stellte den Hauptlokalisationsort dar . Daneben fanden sich auch eher seltene Manifestationen im Bereich der Rippe , Os ilium und Grundphalanx der Hand . In 50% der Faelle wurde auswaertig zunaechst differenzialdiagnostisch ein hochmalignes Osteosarkom oder ein Chondrosarkom diskutiert . Da das Klarzellchondrosarkom ausser in der Epiphyse des proximalen Femurs auch an anderen , eher ungewoehnlichen Stellen des Skeletts auftreten kann , ist die Kenntnis der Histomorphologie dieses Tumors von entscheidender Bedeutung fuer die Diagnosefindung .

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[ "umlsterm" ]

Krankenhausinformationssystem is an umlsterm, Heinrich - Heine - Universitaet is an umlsterm

DerGynaekologe.00330172.ger.abstr_task0

Sentence: Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik .

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[ "umlsterm" ]

Krankenhausinformationssystem is an umlsterm, Heinrich - Heine - Universitaet is an umlsterm

DerGynaekologe.00330172.ger.abstr_task1

Sentence: Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik . Instructions: please typing these entity words according to sentence: Krankenhausinformationssystem, Heinrich - Heine - Universitaet Options: umlsterm

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Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik .

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[ "umlsterm" ]

Krankenhausinformationssystem, Heinrich - Heine - Universitaet

DerGynaekologe.00330172.ger.abstr_task2

Sentence: Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik . Instructions: please extract entity words from the input sentence

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Vor 5 Jahren wurde zum erstenmal ein neues Krankenhausinformationssystem an der Heinrich-Heine-Universitaet Duesseldorf eingefuehrt . Dieser Beitrag beschreibt die Voraussetzungen und die Vorgehensweise bei der Einfuehrung in einer Klinik .

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[ "umlsterm" ]

GTPase is a protein-family, Ras is a protein-family, GTP - bound form of Ras is a protein

1.0alpha7.train.574_task0

Sentence: Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: protein-family, protein

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Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active.

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[ "protein", "protein-family", "chemical" ]

GTPase is a protein-family, Ras is a protein-family, GTP - bound form of Ras is a protein

1.0alpha7.train.574_task1

Sentence: Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active. Instructions: please typing these entity words according to sentence: GTPase, Ras, GTP - bound form of Ras Options: protein-family, protein

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Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active.

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[ "protein", "protein-family", "chemical" ]

GTPase, Ras, GTP - bound form of Ras

1.0alpha7.train.574_task2

Sentence: Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active. Instructions: please extract entity words from the input sentence

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Regulation of the GTPase activity of Ras is crucial, because only the GTP-bound form of Ras is active.

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[ "protein", "protein-family", "chemical" ]

therapy is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, techniques is an umlsterm, psychoanalysis is an umlsterm, techniques is an umlsterm, nature is an umlsterm, human is an umlsterm, character is an umlsterm, human is an umlsterm, object relation is an umlsterm, psychologists is an umlsterm, love is an umlsterm, human is an umlsterm, guidelines is an umlsterm, techniques is an umlsterm, psychoanalytical therapy is an umlsterm

ForumDerPsychoanalyse.80140139.eng.abstr_task0

Sentence: Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy .

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[ "umlsterm" ]

therapy is an umlsterm, therapy is an umlsterm, treatment is an umlsterm, techniques is an umlsterm, psychoanalysis is an umlsterm, techniques is an umlsterm, nature is an umlsterm, human is an umlsterm, character is an umlsterm, human is an umlsterm, object relation is an umlsterm, psychologists is an umlsterm, love is an umlsterm, human is an umlsterm, guidelines is an umlsterm, techniques is an umlsterm, psychoanalytical therapy is an umlsterm

ForumDerPsychoanalyse.80140139.eng.abstr_task1

Sentence: Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy . Instructions: please typing these entity words according to sentence: therapy, therapy, treatment, techniques, psychoanalysis, techniques, nature, human, character, human, object relation, psychologists, love, human, guidelines, techniques, psychoanalytical therapy Options: umlsterm

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Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy .

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[ "umlsterm" ]

therapy, therapy, treatment, techniques, psychoanalysis, techniques, nature, human, character, human, object relation, psychologists, love, human, guidelines, techniques, psychoanalytical therapy

ForumDerPsychoanalyse.80140139.eng.abstr_task2

Sentence: Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy . Instructions: please extract entity words from the input sentence

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Classical insight therapy , derived from Freud , and `maternal' holding therapy , derived from Balint , Winnicott and others , are two contrasting treatment techniques in psychoanalysis . The authors believe that each of these two techniques presupposes specific philosophical basic assumptions about the nature of human beings . The position of Freud is that of the basically traumatic character of human experience . The contra-position of the object relation psychologists stipulates the priority of love in human experience . These assumptions seem to be more latent than overt guidelines of therapeutical techniques and therefore their reconstruction and reformulation have important implications for psychoanalytical therapy .

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[ "umlsterm" ]

Ile646Lys is a GENE-N, gp41 coiled - coil domain is a GENE-N

23522564_task0

Sentence: Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N

[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]

Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation.

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[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Ile646Lys is a GENE-N, gp41 coiled - coil domain is a GENE-N

23522564_task1

Sentence: Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation. Instructions: please typing these entity words according to sentence: Ile646Lys, gp41 coiled - coil domain Options: GENE-N

[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]

Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation.

[ "Addition", "of", "artificial", "salt", "bridge", "by", "Ile646Lys", "mutation", "in", "gp41", "coiled", "-", "coil", "domain", "regulates", "6-helical", "bundle", "formation", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

Ile646Lys, gp41 coiled - coil domain

23522564_task2

Sentence: Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O" ]

Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation.

[ "Addition", "of", "artificial", "salt", "bridge", "by", "Ile646Lys", "mutation", "in", "gp41", "coiled", "-", "coil", "domain", "regulates", "6-helical", "bundle", "formation", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

methanol is a CHEMICAL, aflatoxin is a CHEMICAL, aflatoxin B(1 ) is a CHEMICAL, malondialdehyde is a CHEMICAL, superoxide dismutase is a GENE-N, glutathione is a CHEMICAL, glutathione peroxidase is a GENE-N, aflatoxin is a CHEMICAL, N - methyl - N'-nitro - N - nitrosoguanidine is a CHEMICAL, acridin is a CHEMICAL, aflatoxin is a CHEMICAL

19853_task0

Sentence: Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-N, CHEMICAL

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Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin.

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[ "CHEMICAL", "GENE-N" ]

methanol is a CHEMICAL, aflatoxin is a CHEMICAL, aflatoxin B(1 ) is a CHEMICAL, malondialdehyde is a CHEMICAL, superoxide dismutase is a GENE-N, glutathione is a CHEMICAL, glutathione peroxidase is a GENE-N, aflatoxin is a CHEMICAL, N - methyl - N'-nitro - N - nitrosoguanidine is a CHEMICAL, acridin is a CHEMICAL, aflatoxin is a CHEMICAL

19853_task1

Sentence: Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin. Instructions: please typing these entity words according to sentence: methanol, aflatoxin, aflatoxin B(1 ), malondialdehyde, superoxide dismutase, glutathione, glutathione peroxidase, aflatoxin, N - methyl - N'-nitro - N - nitrosoguanidine, acridin, aflatoxin Options: GENE-N, CHEMICAL

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Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin.

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[ "CHEMICAL", "GENE-N" ]

methanol, aflatoxin, aflatoxin B(1 ), malondialdehyde, superoxide dismutase, glutathione, glutathione peroxidase, aflatoxin, N - methyl - N'-nitro - N - nitrosoguanidine, acridin, aflatoxin

19853_task2

Sentence: Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin. Instructions: please extract entity words from the input sentence

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Antigenotoxic potencies of a lichen species, Evernia prunastri. In this article, the genotoxic and antigenotoxic effects of methanol extract of Evernia prunastri (Huds.) Willd. (MEP) were studied using WP2, Ames (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that MEP has strong antimutagenic potencies on TA1537 and WP2 strains. The highest inhibition rates for MEP on TA1537 and WP2 strains were 37.70% and 69.70%, respectively. According to the SCE test system, MEP reduced the genotoxic effects of aflatoxin. In order to clarify the mechanism underlying the antigenotoxic effects of MEP, the antioxidants were determined. Cotreatments of 5, 10 and 20 µg/mL concentrations of MEP with aflatoxin B(1) decreased the frequencies of SCE and the malondialdehyde level and increased amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The data obtained from this work have clearly shown that MEP has significant antigenotoxic effects which are thought to be partly due to the antioxidant activities and antioxidant inducing capability of MEP. This is the first report indicating the antigenotoxic activities of MEP against several mutagen agents such as N-methyl-N'-nitro-N-nitrosoguanidine, acridin and aflatoxin.

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Doppelblindstudie is an umlsterm, Patienten is an umlsterm, Sufentanil is an umlsterm, Alfentanil is an umlsterm, Analgesie is an umlsterm, Stosswellenlithotripsie is an umlsterm, Sufentanil is an umlsterm, Alfentanil is an umlsterm, Blutdruckverhalten is an umlsterm, Kohlendioxidpartialdruck is an umlsterm, Sauerstoffsaettigung is an umlsterm, Spontanatmung is an umlsterm, Behandlung is an umlsterm, Eigenbeurteilung is an umlsterm, Muedigkeit is an umlsterm, Schmerz is an umlsterm, Patienten is an umlsterm, Beurteilung is an umlsterm, Schmerzen is an umlsterm, Gesamtbeurteilung is an umlsterm, Patienten is an umlsterm, Opioide is an umlsterm, Atemdepression is an umlsterm, Alfentanil is an umlsterm, Sufentanil is an umlsterm, Analgesiequalitaet is an umlsterm, Patienten is an umlsterm, Vigilanzbeurteilung is an umlsterm, Patienten is an umlsterm, Behandlungsende is an umlsterm, Sufentanil is an umlsterm, Sufentanil is an umlsterm, Beurteilung is an umlsterm, Patienten is an umlsterm, Sufentanil is an umlsterm, Analgesie is an umlsterm

DerAnaesthesist.60450330.ger.abstr_task0

Sentence: In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen .

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[ "umlsterm" ]

Doppelblindstudie is an umlsterm, Patienten is an umlsterm, Sufentanil is an umlsterm, Alfentanil is an umlsterm, Analgesie is an umlsterm, Stosswellenlithotripsie is an umlsterm, Sufentanil is an umlsterm, Alfentanil is an umlsterm, Blutdruckverhalten is an umlsterm, Kohlendioxidpartialdruck is an umlsterm, Sauerstoffsaettigung is an umlsterm, Spontanatmung is an umlsterm, Behandlung is an umlsterm, Eigenbeurteilung is an umlsterm, Muedigkeit is an umlsterm, Schmerz is an umlsterm, Patienten is an umlsterm, Beurteilung is an umlsterm, Schmerzen is an umlsterm, Gesamtbeurteilung is an umlsterm, Patienten is an umlsterm, Opioide is an umlsterm, Atemdepression is an umlsterm, Alfentanil is an umlsterm, Sufentanil is an umlsterm, Analgesiequalitaet is an umlsterm, Patienten is an umlsterm, Vigilanzbeurteilung is an umlsterm, Patienten is an umlsterm, Behandlungsende is an umlsterm, Sufentanil is an umlsterm, Sufentanil is an umlsterm, Beurteilung is an umlsterm, Patienten is an umlsterm, Sufentanil is an umlsterm, Analgesie is an umlsterm

DerAnaesthesist.60450330.ger.abstr_task1

Sentence: In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen . Instructions: please typing these entity words according to sentence: Doppelblindstudie, Patienten, Sufentanil, Alfentanil, Analgesie, Stosswellenlithotripsie, Sufentanil, Alfentanil, Blutdruckverhalten, Kohlendioxidpartialdruck, Sauerstoffsaettigung, Spontanatmung, Behandlung, Eigenbeurteilung, Muedigkeit, Schmerz, Patienten, Beurteilung, Schmerzen, Gesamtbeurteilung, Patienten, Opioide, Atemdepression, Alfentanil, Sufentanil, Analgesiequalitaet, Patienten, Vigilanzbeurteilung, Patienten, Behandlungsende, Sufentanil, Sufentanil, Beurteilung, Patienten, Sufentanil, Analgesie Options: umlsterm

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In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen .

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[ "umlsterm" ]

Doppelblindstudie, Patienten, Sufentanil, Alfentanil, Analgesie, Stosswellenlithotripsie, Sufentanil, Alfentanil, Blutdruckverhalten, Kohlendioxidpartialdruck, Sauerstoffsaettigung, Spontanatmung, Behandlung, Eigenbeurteilung, Muedigkeit, Schmerz, Patienten, Beurteilung, Schmerzen, Gesamtbeurteilung, Patienten, Opioide, Atemdepression, Alfentanil, Sufentanil, Analgesiequalitaet, Patienten, Vigilanzbeurteilung, Patienten, Behandlungsende, Sufentanil, Sufentanil, Beurteilung, Patienten, Sufentanil, Analgesie

DerAnaesthesist.60450330.ger.abstr_task2

Sentence: In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen . Instructions: please extract entity words from the input sentence

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In der prospektiven randomisierten Doppelblindstudie wurden 62 Patienten der ASA-Klassen I-II in zwei Gruppen verteilt . Gruppe I erhielt Sufentanil , Gruppe II Alfentanil zur intravenoesen Analgesie bei extrakorporaler Stosswellenlithotripsie ( ESWL ) . Die Dosierung fuer Sufentanil betrug durchschnittlich 0,11 mg , fuer Alfentanil 4,2 mg . Untersucht wurden Blutdruckverhalten , transkutaner Kohlendioxidpartialdruck ( PtcCO2 ) und Sauerstoffsaettigung mittels Pulsoximetrie ( spO2) bei Spontanatmung mit O2-Maske ( 6 l/min ) vor und waehrend der Behandlung und waehrend 2 h postoperativer Aufwachraumzeit . Gleichzeitig erfolgten eine Eigenbeurteilung von Muedigkeit und Schmerz anhand der visuellen Analogskala ( VAS ) durch den Patienten sowie eine Beurteilung der Vigilanz und der Schmerzen durch den Anaesthesisten ( VAS ) . Nach Abschluss der Ueberwachungsphase erfolgte eine Gesamtbeurteilung durch den Patienten , den Anaesthesisten und den Behandler . Beide Opioide boten stabile kardiozirkulatorische Verhaeltnisse . Die opioidinduzierte Atemdepression war sowohl unter Alfentanil als auch unter Sufentanil gleich ausgepraegt . Die Analgesiequalitaet wurde sowohl vom Patienten als auch vom Anaesthesisten gleich gut beurteilt . Waehrend die Vigilanzbeurteilung durch den Anaesthesisten keine Unterschiede zeigte , fuehlten sich die Patienten bis 2 h nach Behandlungsende signifikant mueder unter Sufentanil . Opioidtypische Nebenwirkungen traten unter Sufentanil haeufiger auf 24 vs. 11 ) . ( Diese fuehrten zu einer insgesamt schlechteren Beurteilung des Narkoseverfahrens durch die Patienten und den Anaesthesisten . Dies laesst Sufentanil fuer die intravenoese Analgesie weniger geeignet erscheinen .

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[ "umlsterm" ]

Spi - B is a Protein, Spi - B is a Protein, Spi-1 is a Protein, PU.1 is a Protein, Ets domain is a Entity, DNA is a Entity, Spi - B is a Protein, DNA sequences is a Entity, 5'-GGAA-3 ' is a Entity, Spi - B is a Protein, Spi - B is a Protein, deltaSpi - B is a Protein, Ets domain is a Entity, deltaspi - B is a Protein, spi - B is a Protein, DeltaSpi - B is a Protein, DNA is a Entity, delta Spi - B is a Protein, Spi - B is a Protein, Spi - B is a Protein

212_task0

Sentence: An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

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An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity.

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[ "Entity", "Protein" ]

Spi - B is a Protein, Spi - B is a Protein, Spi-1 is a Protein, PU.1 is a Protein, Ets domain is a Entity, DNA is a Entity, Spi - B is a Protein, DNA sequences is a Entity, 5'-GGAA-3 ' is a Entity, Spi - B is a Protein, Spi - B is a Protein, deltaSpi - B is a Protein, Ets domain is a Entity, deltaspi - B is a Protein, spi - B is a Protein, DeltaSpi - B is a Protein, DNA is a Entity, delta Spi - B is a Protein, Spi - B is a Protein, Spi - B is a Protein

212_task1

Sentence: An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity. Instructions: please typing these entity words according to sentence: Spi - B, Spi - B, Spi-1, PU.1, Ets domain, DNA, Spi - B, DNA sequences, 5'-GGAA-3 ', Spi - B, Spi - B, deltaSpi - B, Ets domain, deltaspi - B, spi - B, DeltaSpi - B, DNA, delta Spi - B, Spi - B, Spi - B Options: Entity, Protein

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An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity.

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[ "Entity", "Protein" ]

Spi - B, Spi - B, Spi-1, PU.1, Ets domain, DNA, Spi - B, DNA sequences, 5'-GGAA-3 ', Spi - B, Spi - B, deltaSpi - B, Ets domain, deltaspi - B, spi - B, DeltaSpi - B, DNA, delta Spi - B, Spi - B, Spi - B

212_task2

Sentence: An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity. Instructions: please extract entity words from the input sentence

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An alternatively spliced isoform of the Spi-B transcription factor. Spi-B is an Ets transcription factor related to the oncoprotein Spi-1/PU.1 and highly expressed in B lymphoid cells. The Ets proteins share a conserved Ets domain that mediates specific DNA binding. Spi-B binds DNA sequences containing a core 5'-GGAA-3' and activates transcription through this motif. Up to date, the biological function of Spi-B remains unknown. Here, we describe the characterization of an alternatively spliced variant of Spi-B, named deltaSpi-B, which has lost the Ets domain. In B lymphoid cells, deltaspi-B and spi-B mRNAs were present simultaneously in a ratio of around 10%. DeltaSpi-B product was not able to bind DNA and was recovered in cytoplasmic cellular extracts. We raise the hypothesis that delta Spi-B might affect Spi-B function by recruiting factors involved in Spi-B activity.

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[ "Entity", "Protein" ]

TDP-43 is a protein, UG ( or TG ) single - stranded dinucleotide is a DNA

1.0alpha7.train.483_task0

Sentence: Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA, protein

[ "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats.

[ " ", "Interestingly", ",", " ", "TDP-43", "can", "bind", "a", "minimum", "number", "of", "six", " ", "UG", "(", "or", "TG", ")", "single", "-", "stranded", "dinucleotide", "stretches", ",", "and", "binding", "affinity", "increases", "with", "the", "number", "of", "repeats", ".", " " ]

[ "DNA", "protein" ]

TDP-43 is a protein, UG ( or TG ) single - stranded dinucleotide is a DNA

1.0alpha7.train.483_task1

Sentence: Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats. Instructions: please typing these entity words according to sentence: TDP-43, UG ( or TG ) single - stranded dinucleotide Options: DNA, protein

[ "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats.

[ " ", "Interestingly", ",", " ", "TDP-43", "can", "bind", "a", "minimum", "number", "of", "six", " ", "UG", "(", "or", "TG", ")", "single", "-", "stranded", "dinucleotide", "stretches", ",", "and", "binding", "affinity", "increases", "with", "the", "number", "of", "repeats", ".", " " ]

[ "DNA", "protein" ]

TDP-43, UG ( or TG ) single - stranded dinucleotide

1.0alpha7.train.483_task2

Sentence: Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats.

[ " ", "Interestingly", ",", " ", "TDP-43", "can", "bind", "a", "minimum", "number", "of", "six", " ", "UG", "(", "or", "TG", ")", "single", "-", "stranded", "dinucleotide", "stretches", ",", "and", "binding", "affinity", "increases", "with", "the", "number", "of", "repeats", ".", " " ]

[ "DNA", "protein" ]

Protein kinase C is a protein_molecule, p21ras is a DNA_domain_or_region, activated T cells is a cell_type

6933_task0

Sentence: Protein kinase C is not a downstream effector of p21ras in activated T cells. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: cell_type, DNA_domain_or_region, protein_molecule

[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O" ]

Protein kinase C is not a downstream effector of p21ras in activated T cells.

[ "Protein", "kinase", "C", "is", "not", "a", "downstream", "effector", "of", "p21ras", "in", "activated", "T", "cells", "." ]

[ "other_name", "DNA_domain_or_region", "cell_line", "cell_type", "protein_molecule", "other_organic_compound", "protein_family_or_group", "atom" ]

Protein kinase C is a protein_molecule, p21ras is a DNA_domain_or_region, activated T cells is a cell_type

6933_task1

Sentence: Protein kinase C is not a downstream effector of p21ras in activated T cells. Instructions: please typing these entity words according to sentence: Protein kinase C, p21ras, activated T cells Options: cell_type, DNA_domain_or_region, protein_molecule

[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O" ]

Protein kinase C is not a downstream effector of p21ras in activated T cells.

[ "Protein", "kinase", "C", "is", "not", "a", "downstream", "effector", "of", "p21ras", "in", "activated", "T", "cells", "." ]

[ "other_name", "DNA_domain_or_region", "cell_line", "cell_type", "protein_molecule", "other_organic_compound", "protein_family_or_group", "atom" ]

Protein kinase C, p21ras, activated T cells

6933_task2

Sentence: Protein kinase C is not a downstream effector of p21ras in activated T cells. Instructions: please extract entity words from the input sentence

[ "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "O", "B-cell_type", "I-cell_type", "I-cell_type", "O" ]

Protein kinase C is not a downstream effector of p21ras in activated T cells.

[ "Protein", "kinase", "C", "is", "not", "a", "downstream", "effector", "of", "p21ras", "in", "activated", "T", "cells", "." ]

[ "other_name", "DNA_domain_or_region", "cell_line", "cell_type", "protein_molecule", "other_organic_compound", "protein_family_or_group", "atom" ]

thrombogenic factors is a Gene_or_gene_product, Hemostatic factors is a Gene_or_gene_product, thrombotic plugs is a Pathological_formation, vascular is a Multi-tissue_structure, hemostatic factors is a Gene_or_gene_product, intimal is a Tissue, lipid - rich plaque is a Pathological_formation, lesions is a Pathological_formation, intimal is a Tissue, Platelets is a Cell, thrombus is a Pathological_formation, intimal is a Tissue, platelet is a Cell, thrombus is a Pathological_formation, Tissue factor is a Gene_or_gene_product, TF is a Gene_or_gene_product, blood is a Organism_substance, atherosclerotic lesions is a Pathological_formation, humans is a Organism, thrombin is a Gene_or_gene_product, fibrin is a Gene_or_gene_product, TF is a Gene_or_gene_product, TF is a Gene_or_gene_product, cell is a Cell, TF is a Gene_or_gene_product, protease - activated receptor 2 is a Gene_or_gene_product

86_task0

Sentence: Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Tissue, Gene_or_gene_product, Organism_substance, Pathological_formation, Organism, Multi-tissue_structure, Cell

[ "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "B-Organism", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis.

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[ "Gene_or_gene_product", "Pathological_formation", "Cell", "Multi-tissue_structure", "Tissue", "Organism", "Organism_substance" ]

thrombogenic factors is a Gene_or_gene_product, Hemostatic factors is a Gene_or_gene_product, thrombotic plugs is a Pathological_formation, vascular is a Multi-tissue_structure, hemostatic factors is a Gene_or_gene_product, intimal is a Tissue, lipid - rich plaque is a Pathological_formation, lesions is a Pathological_formation, intimal is a Tissue, Platelets is a Cell, thrombus is a Pathological_formation, intimal is a Tissue, platelet is a Cell, thrombus is a Pathological_formation, Tissue factor is a Gene_or_gene_product, TF is a Gene_or_gene_product, blood is a Organism_substance, atherosclerotic lesions is a Pathological_formation, humans is a Organism, thrombin is a Gene_or_gene_product, fibrin is a Gene_or_gene_product, TF is a Gene_or_gene_product, TF is a Gene_or_gene_product, cell is a Cell, TF is a Gene_or_gene_product, protease - activated receptor 2 is a Gene_or_gene_product

86_task1

Sentence: Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis. Instructions: please typing these entity words according to sentence: thrombogenic factors, Hemostatic factors, thrombotic plugs, vascular, hemostatic factors, intimal, lipid - rich plaque, lesions, intimal, Platelets, thrombus, intimal, platelet, thrombus, Tissue factor, TF, blood, atherosclerotic lesions, humans, thrombin, fibrin, TF, TF, cell, TF, protease - activated receptor 2 Options: Tissue, Gene_or_gene_product, Organism_substance, Pathological_formation, Organism, Multi-tissue_structure, Cell

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Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis.

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[ "Gene_or_gene_product", "Pathological_formation", "Cell", "Multi-tissue_structure", "Tissue", "Organism", "Organism_substance" ]

thrombogenic factors, Hemostatic factors, thrombotic plugs, vascular, hemostatic factors, intimal, lipid - rich plaque, lesions, intimal, Platelets, thrombus, intimal, platelet, thrombus, Tissue factor, TF, blood, atherosclerotic lesions, humans, thrombin, fibrin, TF, TF, cell, TF, protease - activated receptor 2

86_task2

Sentence: Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "B-Multi-tissue_structure", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "I-Pathological_formation", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "O", "O", "O", "O", "O", "B-Tissue", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "O", "B-Tissue", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "B-Pathological_formation", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Organism_substance", "O", "O", "O", "O", "O", "O", "O", "O", "B-Pathological_formation", "I-Pathological_formation", "O", "B-Organism", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "B-Cell", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "I-Gene_or_gene_product", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Role of thrombogenic factors in the development of atherosclerosis. Hemostatic factors play a crucial role in generating thrombotic plugs at sites of vascular damage (atherothrombosis). However, whether hemostatic factors contribute directly or indirectly to the pathogenesis of atherosclerosis remains uncertain. Autopsy studies have revealed that intimal thickening represents the first stage of atherosclerosis and that lipid-rich plaque arises from such lesions. Several factors contribute to the start of intimal thickening. Platelets release several growth factors and bioactive agents that play a central role in development of not only thrombus but also of intimal thickening. We have been investigating which coagulation factors simultaneously, or subsequently with platelet aggregation, participate in thrombus formation. Tissue factor (TF) is an essential initiator of blood coagulation that is expressed in various stages of atherosclerotic lesions in humans and other animals. Factors including thrombin and fibrin, which are downstream of the coagulation cascade activated by TF, also contribute to atherosclerosis. TF is involved in cell migration, embryogenesis and angiogenesis. Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis.

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[ "Gene_or_gene_product", "Pathological_formation", "Cell", "Multi-tissue_structure", "Tissue", "Organism", "Organism_substance" ]

patients is an umlsterm, phototoxic contact dermatitis is an umlsterm, albus is an umlsterm, gas is an umlsterm, plant is an umlsterm, family is an umlsterm, phototoxic contact dermatitis is an umlsterm, albus is an umlsterm, furocoumarins is an umlsterm, 5-methoxypsoralen is an umlsterm, bergapten is an umlsterm, 8-methoxypsoralen is an umlsterm, alkaloid is an umlsterm, gas is an umlsterm, plant is an umlsterm, differential diagnosis is an umlsterm, phototoxic contact dermatitis is an umlsterm

DerHautarzt.60470708.eng.abstr_task0

Sentence: We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis .

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[ "umlsterm" ]

patients is an umlsterm, phototoxic contact dermatitis is an umlsterm, albus is an umlsterm, gas is an umlsterm, plant is an umlsterm, family is an umlsterm, phototoxic contact dermatitis is an umlsterm, albus is an umlsterm, furocoumarins is an umlsterm, 5-methoxypsoralen is an umlsterm, bergapten is an umlsterm, 8-methoxypsoralen is an umlsterm, alkaloid is an umlsterm, gas is an umlsterm, plant is an umlsterm, differential diagnosis is an umlsterm, phototoxic contact dermatitis is an umlsterm

DerHautarzt.60470708.eng.abstr_task1

Sentence: We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis . Instructions: please typing these entity words according to sentence: patients, phototoxic contact dermatitis, albus, gas, plant, family, phototoxic contact dermatitis, albus, furocoumarins, 5-methoxypsoralen, bergapten, 8-methoxypsoralen, alkaloid, gas, plant, differential diagnosis, phototoxic contact dermatitis Options: umlsterm

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We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis .

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[ "umlsterm" ]

patients, phototoxic contact dermatitis, albus, gas, plant, family, phototoxic contact dermatitis, albus, furocoumarins, 5-methoxypsoralen, bergapten, 8-methoxypsoralen, alkaloid, gas, plant, differential diagnosis, phototoxic contact dermatitis

DerHautarzt.60470708.eng.abstr_task2

Sentence: We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis . Instructions: please extract entity words from the input sentence

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We report two patients with bullous phototoxic contact dermatitis caused by Dictamnus albus L. ( gas plant ) which belongs to the Rutaceae family . In both cases long lasting postinflammatory hyperpigmentations were observed as a result of the phototoxic contact dermatitis . The phototoxic components of Dictamnus albus L. are the furocoumarins 5-methoxypsoralen ( bergapten ) and 8-methoxypsoralen , and the alkaloid dictamnin whose phototoxic properties were recently discovered . Even though reactions to the gas plant have been infrequently reported , it is becoming more popular with gardenus and should be considered in the differential diagnosis of phototoxic contact dermatitis .

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[ "umlsterm" ]

ulcerative is a Pathological_formation, colorectal is a Multi-tissue_structure, colorectal dysplasia is a Pathological_formation, cancer is a Cancer, ulcerative is a Pathological_formation, colon cancer is a Cancer, colon cancer is a Cancer, colonic tumors is a Cancer, dysplasia is a Pathological_formation, adenocarcinoma is a Cancer, high - grade lesions is a Pathological_formation, high - grade dysplasia is a Pathological_formation, carcinoma in situ is a Cancer, invasive adenocarcinoma is a Cancer, high - grade lesions is a Pathological_formation, high - grade lesions is a Pathological_formation, colorectal is a Multi-tissue_structure, colorectal is a Multi-tissue_structure, colorectal is a Multi-tissue_structure

PMID-14652292_task0

Sentence: Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Pathological_formation, Cancer, Multi-tissue_structure

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Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model.

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[ "Cancer", "Pathological_formation", "Multi-tissue_structure" ]

ulcerative is a Pathological_formation, colorectal is a Multi-tissue_structure, colorectal dysplasia is a Pathological_formation, cancer is a Cancer, ulcerative is a Pathological_formation, colon cancer is a Cancer, colon cancer is a Cancer, colonic tumors is a Cancer, dysplasia is a Pathological_formation, adenocarcinoma is a Cancer, high - grade lesions is a Pathological_formation, high - grade dysplasia is a Pathological_formation, carcinoma in situ is a Cancer, invasive adenocarcinoma is a Cancer, high - grade lesions is a Pathological_formation, high - grade lesions is a Pathological_formation, colorectal is a Multi-tissue_structure, colorectal is a Multi-tissue_structure, colorectal is a Multi-tissue_structure

PMID-14652292_task1

Sentence: Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model. Instructions: please typing these entity words according to sentence: ulcerative, colorectal, colorectal dysplasia, cancer, ulcerative, colon cancer, colon cancer, colonic tumors, dysplasia, adenocarcinoma, high - grade lesions, high - grade dysplasia, carcinoma in situ, invasive adenocarcinoma, high - grade lesions, high - grade lesions, colorectal, colorectal, colorectal Options: Pathological_formation, Cancer, Multi-tissue_structure

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Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model.

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[ "Cancer", "Pathological_formation", "Multi-tissue_structure" ]

ulcerative, colorectal, colorectal dysplasia, cancer, ulcerative, colon cancer, colon cancer, colonic tumors, dysplasia, adenocarcinoma, high - grade lesions, high - grade dysplasia, carcinoma in situ, invasive adenocarcinoma, high - grade lesions, high - grade lesions, colorectal, colorectal, colorectal

PMID-14652292_task2

Sentence: Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model. Instructions: please extract entity words from the input sentence

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Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Folate supplementation may reduce the risk of colorectal dysplasia and cancer in subjects with chronic ulcerative colitis (UC). The interleukin (IL) 2- and beta(2)-microglobulin (beta(2)m)-deficient (IL-2(null) x beta(2)m(null)) mice spontaneously develop colon cancer in the setting of chronic UC. This study investigated the effects of dietary folate on the development of UC-associated colon cancer in the IL-2(null) x beta(2)m(null) mice. Weaning IL-2(null) x beta(2)m(null) mice were randomized to receive 0 (deficient; n = 40), 2 (basal requirement; control; n = 46), or 8 (supplemented; n = 36) mg folate/kg diet for 32 weeks. At necropsy, all macroscopic colonic tumors were identified and histologically classified as dysplasia or adenocarcinoma. The incidence of high-grade lesions (high-grade dysplasia/carcinoma in situ and invasive adenocarcinoma) in the folate-supplemented group was 46% lower than that in the control group (35.3% versus 65.1%, P = 0.009). The incidence of high-grade lesions in the folate-deficient group was also 49% lower than that in the control group (33.3% versus 65.1%, P = 0.007). The higher mortality rate in the folate-deficient group compared with the other two groups (25% versus 6.5% and 5.6%, P < 0.02) partially accounted for the low incidence of high-grade lesions in this group. These data indicate that dietary folate supplementation at 4x the basal dietary requirement significantly suppresses UC-associated colorectal carcinogenesis in the IL-2(null) x beta(2)m(null) mice. These data also suggest that folate deficiency may inhibit colorectal carcinogenesis in chronic UC. However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model.

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[ "Cancer", "Pathological_formation", "Multi-tissue_structure" ]

Patienten is an umlsterm, Diagnostik is an umlsterm, Diagnostik is an umlsterm, neurologische Untersuchung is an umlsterm, Farbdoppler is an umlsterm, Patienten is an umlsterm, ACC is an umlsterm, ACC is an umlsterm, Atlasschlinge is an umlsterm, Patienten is an umlsterm, Angiographie is an umlsterm

Gefaesschirurgie.80030088.ger.abstr_task0

Sentence: Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation .

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[ "umlsterm" ]

Patienten is an umlsterm, Diagnostik is an umlsterm, Diagnostik is an umlsterm, neurologische Untersuchung is an umlsterm, Farbdoppler is an umlsterm, Patienten is an umlsterm, ACC is an umlsterm, ACC is an umlsterm, Atlasschlinge is an umlsterm, Patienten is an umlsterm, Angiographie is an umlsterm

Gefaesschirurgie.80030088.ger.abstr_task1

Sentence: Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation . Instructions: please typing these entity words according to sentence: Patienten, Diagnostik, Diagnostik, neurologische Untersuchung, Farbdoppler, Patienten, ACC, ACC, Atlasschlinge, Patienten, Angiographie Options: umlsterm

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Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation .

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[ "umlsterm" ]

Patienten, Diagnostik, Diagnostik, neurologische Untersuchung, Farbdoppler, Patienten, ACC, ACC, Atlasschlinge, Patienten, Angiographie

Gefaesschirurgie.80030088.ger.abstr_task2

Sentence: Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation . Instructions: please extract entity words from the input sentence

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Die Indikation zur Vertebralisrekonstruktion ist im Gegensatz zu den Eingriffen an der Karotisstrombahn nicht standardisiert . In einer prospektiven Untersuchung an 44 Patienten sollte gezeigt werden , ob eine erweiterte praeoperative Diagnostik die Entscheidung zum operativen Vorgehen erleichtern kann . Die Diagnostik beinhaltete i . a. DSA , CCT , MRT , Langzeit-EKG , otoneurologische und neurologische Untersuchung und Vertebralisflussmessung mittels Farbdoppler . Wir verglichen die prae- u. postoperativen Befunde mit den subjektiven Beschwerden der Patienten . Operativ wurde entweder eine Vertebralistransposition in die ACC vorgenommen oder ein C1-Bypass zwischen ACC und Atlasschlinge implantiert . Bei der Nachuntersuchung 6 - 9 Monate postoperativ waren 72% der Patienten deutlich gebessert oder beschwerdefrei . Die Validitaet der angewandten Diagnostika in Hinblick auf einen Operationserfolg enttaeuschte , insbesondere die Vertebralisflussmessung . Fuer uns sind nach ueber 600 Eingriffen seit 1980 weiterhin exakte Anamnese und suffiziente Angiographie entscheidend fuer die Operationsindikation .

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[ "umlsterm" ]

cyproheptadine is a Intervention_Pharmacological, in human plasma is a Participant_Condition, Chromatography is a Intervention_Physical

49789_task0

Sentence: Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Intervention_Pharmacological, Participant_Condition

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Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine .

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[ "Participant_Condition", "Intervention_Pharmacological", "Intervention_Physical" ]

cyproheptadine is a Intervention_Pharmacological, in human plasma is a Participant_Condition, Chromatography is a Intervention_Physical

49789_task1

Sentence: Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine . Instructions: please typing these entity words according to sentence: cyproheptadine, in human plasma, Chromatography Options: Intervention_Physical, Intervention_Pharmacological, Participant_Condition

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Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine .

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[ "Participant_Condition", "Intervention_Pharmacological", "Intervention_Physical" ]

cyproheptadine, in human plasma, Chromatography

49789_task2

Sentence: Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine . Instructions: please extract entity words from the input sentence

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Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study . A rapid , sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard ( IS ) is described . The analyte and the IS were extracted from plasma by liquid-liquid extraction using a diethyl-ether/dichloromethane ( 70/30 ; v/v ) solvent . After removing and drying the organic phase , the extracts were reconstituted with a fixed volume of acetonitrile/water ( 50/50 v/v ) +0.1 % of acetic acid . The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry ( LC-MS/MS ) . Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column , ( 150 mm x 4.6 mm I.D. ) . The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL ( r2 > 0.99 ) . The limit of quantification was 0.05 ng/mL . This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide ( 4 mg + 1 mg ) tablet formulations ( Cobactin® [ cyproheptadine + cobamamide ] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda . and Cobavital® from Solvay Farma ( standard reference formulation ) ) . A single 4 mg + 1 mg [ cyproheptadine + cobamamide ] dose of each formulation was administered to healthy volunteers . The study was conducted using an open , randomized , two-period crossover design with a 1-week washout interval . Since the 90 % CI for Cmax and AUCs ratios were all within the 80-125 % bioequivalence limit proposed by the US Food and Drug Administration , it was concluded that the cyproheptadine test formulation ( Cobactin® ) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine .

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[ "Participant_Condition", "Intervention_Pharmacological", "Intervention_Physical" ]

intravenoese Anaesthesie is an umlsterm, Tageschirurgie is an umlsterm, Wiederherstellung is an umlsterm, Doppelblindstudie is an umlsterm, Patienten is an umlsterm, Cholezystektomie is an umlsterm, Propofol is an umlsterm, Methohexital is an umlsterm, Isofluran is an umlsterm, Merkfaehigkeit is an umlsterm, Schmerz is an umlsterm, Uebelkeit is an umlsterm, Muedigkeit is an umlsterm, Propofol is an umlsterm, Patienten is an umlsterm, Methohexital is an umlsterm, Isofluran is an umlsterm, Patienten is an umlsterm, Uebelkeit is an umlsterm, Isofluran is an umlsterm, Patienten is an umlsterm, laparoskopische Cholezystektomie is an umlsterm, Anaesthesieverfahren is an umlsterm

DerAnaesthesist.40430573.ger.abstr_task0

Sentence: Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden .

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[ "umlsterm" ]

intravenoese Anaesthesie is an umlsterm, Tageschirurgie is an umlsterm, Wiederherstellung is an umlsterm, Doppelblindstudie is an umlsterm, Patienten is an umlsterm, Cholezystektomie is an umlsterm, Propofol is an umlsterm, Methohexital is an umlsterm, Isofluran is an umlsterm, Merkfaehigkeit is an umlsterm, Schmerz is an umlsterm, Uebelkeit is an umlsterm, Muedigkeit is an umlsterm, Propofol is an umlsterm, Patienten is an umlsterm, Methohexital is an umlsterm, Isofluran is an umlsterm, Patienten is an umlsterm, Uebelkeit is an umlsterm, Isofluran is an umlsterm, Patienten is an umlsterm, laparoskopische Cholezystektomie is an umlsterm, Anaesthesieverfahren is an umlsterm

DerAnaesthesist.40430573.ger.abstr_task1

Sentence: Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden . Instructions: please typing these entity words according to sentence: intravenoese Anaesthesie, Tageschirurgie, Wiederherstellung, Doppelblindstudie, Patienten, Cholezystektomie, Propofol, Methohexital, Isofluran, Merkfaehigkeit, Schmerz, Uebelkeit, Muedigkeit, Propofol, Patienten, Methohexital, Isofluran, Patienten, Uebelkeit, Isofluran, Patienten, laparoskopische Cholezystektomie, Anaesthesieverfahren Options: umlsterm

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Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden .

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[ "umlsterm" ]

intravenoese Anaesthesie, Tageschirurgie, Wiederherstellung, Doppelblindstudie, Patienten, Cholezystektomie, Propofol, Methohexital, Isofluran, Merkfaehigkeit, Schmerz, Uebelkeit, Muedigkeit, Propofol, Patienten, Methohexital, Isofluran, Patienten, Uebelkeit, Isofluran, Patienten, laparoskopische Cholezystektomie, Anaesthesieverfahren

DerAnaesthesist.40430573.ger.abstr_task2

Sentence: Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden . Instructions: please extract entity words from the input sentence

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Die totale intravenoese Anaesthesie ( TIVA ) wird in der Tageschirurgie zunehmend eingesetzt , weil schnelleres Erwachen und eine raschere Wiederherstellung der psychomotorischen Funktionen erwartet werden . In einer randomisierten Doppelblindstudie an 51 Patienten zur laparoskopischen Cholezystektomie wurde das Aufwachverhalten nach einer TIVA mit Propofol , einer TIVA mit Methohexital und einer balanced anaesthesia mit Isofluran in den ersten 6 Stunden postoperativ anhand der Aufwachzeit , der Orientiertheit , der Merkfaehigkeit , eines Rechentests und der Wortgenerierungsfaehigkeit untersucht . Die Befindlichkeit wurde mit einer visuellen Analogskala fuer Schmerz , Uebelkeit und Muedigkeit beurteilt . Nach der TIVA mit Propofol erwachten die Patienten schneller als nach Methohexital und auch geringfuegig schneller als nach Isofluran . Mit dem Verzicht auf Lachgas ist die Quote der Patienten , die ueber Uebelkeit klagten , auch nach Isofluran erstaunlich klein ( 24% ) . Die Unterschiede in den drei Gruppen sind insgesamt gering , insbesondere sind die Kooperationsfaehigkeit und die Mobilisierbarkeit der Patienten in keiner Gruppe eingeschraenkt . Fuer die laparoskopische Cholezystektomie koennen alle drei untersuchten Anaesthesieverfahren als gut geeignet angesehen werden .

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[ "umlsterm" ]

Pyridoxal 5'-phosphate is a CHEMICAL, pyridox(am)ine-5'-phosphate oxidase is a GENE-Y, PNPO is a GENE-Y, pyridoxal 5'-phosphate is a CHEMICAL, PLP is a CHEMICAL, PLP is a CHEMICAL, PNPO is a GENE-Y

11702_task0

Sentence: Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, CHEMICAL

[ "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-Y", "O", "O" ]

Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency.

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[ "GENE-Y", "CHEMICAL" ]

Pyridoxal 5'-phosphate is a CHEMICAL, pyridox(am)ine-5'-phosphate oxidase is a GENE-Y, PNPO is a GENE-Y, pyridoxal 5'-phosphate is a CHEMICAL, PLP is a CHEMICAL, PLP is a CHEMICAL, PNPO is a GENE-Y

11702_task1

Sentence: Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency. Instructions: please typing these entity words according to sentence: Pyridoxal 5'-phosphate, pyridox(am)ine-5'-phosphate oxidase, PNPO, pyridoxal 5'-phosphate, PLP, PLP, PNPO Options: GENE-Y, CHEMICAL

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Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency.

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[ "GENE-Y", "CHEMICAL" ]

Pyridoxal 5'-phosphate, pyridox(am)ine-5'-phosphate oxidase, PNPO, pyridoxal 5'-phosphate, PLP, PLP, PNPO

11702_task2

Sentence: Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency. Instructions: please extract entity words from the input sentence

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Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism. These conditions are often unresponsive to treatment with conventional antiepileptic drugs. Six children with pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency presented with neonatal epileptic encephalopathy. Two were treated with pyridoxal 5'-phosphate (PLP) within the first month of life and showed normal development or moderate psychomotor retardation thereafter. Four children with late or no treatment died or showed severe mental handicap. All of the children showed atypical biochemical findings. Prompt treatment with PLP in all neonates and infants with epileptic encephalopathy should become mandatory, permitting normal development in at least some of those affected with PNPO deficiency.

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[ "GENE-Y", "CHEMICAL" ]

Patienten is an umlsterm, vorderen Kreuzbandes is an umlsterm, Fragebogen is an umlsterm, Patienten is an umlsterm, Beurteilung is an umlsterm, Patienten is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Kohlefaserprothesen is an umlsterm, Zeit is an umlsterm, Prothesen is an umlsterm, Rolle is an umlsterm, Langzeitverlauf is an umlsterm, Synovitis is an umlsterm, Enzymreaktionen is an umlsterm, Gelenkdestruktion is an umlsterm, Gelenkerguesse is an umlsterm, Schmerzen is an umlsterm

DerChirurg.70681119.ger.abstr_task0

Sentence: Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert .

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[ "umlsterm" ]

Patienten is an umlsterm, vorderen Kreuzbandes is an umlsterm, Fragebogen is an umlsterm, Patienten is an umlsterm, Beurteilung is an umlsterm, Patienten is an umlsterm, Komplikationen is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Kohlefaserprothesen is an umlsterm, Zeit is an umlsterm, Prothesen is an umlsterm, Rolle is an umlsterm, Langzeitverlauf is an umlsterm, Synovitis is an umlsterm, Enzymreaktionen is an umlsterm, Gelenkdestruktion is an umlsterm, Gelenkerguesse is an umlsterm, Schmerzen is an umlsterm

DerChirurg.70681119.ger.abstr_task1

Sentence: Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert . Instructions: please typing these entity words according to sentence: Patienten, vorderen Kreuzbandes, Fragebogen, Patienten, Beurteilung, Patienten, Komplikationen, Patienten, Patienten, Kohlefaserprothesen, Zeit, Prothesen, Rolle, Langzeitverlauf, Synovitis, Enzymreaktionen, Gelenkdestruktion, Gelenkerguesse, Schmerzen Options: umlsterm

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Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert .

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[ "umlsterm" ]

Patienten, vorderen Kreuzbandes, Fragebogen, Patienten, Beurteilung, Patienten, Komplikationen, Patienten, Patienten, Kohlefaserprothesen, Zeit, Prothesen, Rolle, Langzeitverlauf, Synovitis, Enzymreaktionen, Gelenkdestruktion, Gelenkerguesse, Schmerzen

DerChirurg.70681119.ger.abstr_task2

Sentence: Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert . Instructions: please extract entity words from the input sentence

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Zusammenfassung . 120 Patienten nach Ersatz des vorderen Kreuzbandes ( VKB ) mit La-Fil-Kohlefaserprothese wurden retrospektiv mittels Fragebogen und 80 Patienten klinisch nach im Mittel 10 +/- 2 Jahren untersucht . Die subjektive Beurteilung ergab 60 % zufriedene Patienten bei deutlich vermindertem Aktivitaetsniveau . Als objektive Komplikationen waren bei 72,5 % der Patienten die C-Faser rupturiert und bei 68 % der Patienten synoviale Reaktionen zu beobachten . Roentgenologisch zeigten sich in bis zu 59 % der Faelle arthrotische Veraenderungen . Die mit C-Faser rekonstruierten Collateralbaender ( 85 % medial , 5,8 % lateral ) waren zu 75 % stabil . Fuer das Versagen der Kohlefaserprothesen scheinen weniger die Aktivitaet oder die Zeit als vielmehr das Einwachsverhalten der Prothesen eine Rolle zu spielen . Im Langzeitverlauf fuehrt die reaktive Synovitis ueber katabole Enzymreaktionen zur Gelenkdestruktion . Klinische Zeichen sind rezidivierende Gelenkerguesse und Schmerzen . Zur Unterbrechung des Circulus vitiosus ist die arthroskopische ) Synovektomie ( indiziert .

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[ "umlsterm" ]

juveniles Xanthogranulom is an umlsterm, Diagnose is an umlsterm, Riesenzellen is an umlsterm, Natur is an umlsterm

DerHautarzt.50460194.ger.abstr_task0

Sentence: Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern .

[ "Zusammenfassung", ".", "Es", "wird", "ueber", "ein", "grossknotiges", "multizentrisches", "juveniles", "Xanthogranulom", "berichtet", ",", "dessen", "ungewoehnlicher", "klinischer", "und", "histologischer", "Aspekt", "die", "Diagnose", "anfaenglich", "nicht", "zuliess", ".", "Die", "inzwischen", "mehr", "als", "2", "Jahre", "waehrende", "Spontanregression", "mit", "der", "Aenderung", "des", "primaer", "monomorphen", "fibrozytischen", "hin", "zu", "einem", "polymorphen", "histiozytischen", "Aspekt", "mit", "zahlreichen", "fettspeichernden", "Riesenzellen", "sowie", "der", "fehlende", "Nachweis", "spezifischer", "Zellorganellen", "konnten", "die", "Natur", "der", "Erkrankung", "sichern", "." ]

[ "umlsterm" ]

juveniles Xanthogranulom is an umlsterm, Diagnose is an umlsterm, Riesenzellen is an umlsterm, Natur is an umlsterm

DerHautarzt.50460194.ger.abstr_task1

Sentence: Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern . Instructions: please typing these entity words according to sentence: juveniles Xanthogranulom, Diagnose, Riesenzellen, Natur Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern .

[ "Zusammenfassung", ".", "Es", "wird", "ueber", "ein", "grossknotiges", "multizentrisches", "juveniles", "Xanthogranulom", "berichtet", ",", "dessen", "ungewoehnlicher", "klinischer", "und", "histologischer", "Aspekt", "die", "Diagnose", "anfaenglich", "nicht", "zuliess", ".", "Die", "inzwischen", "mehr", "als", "2", "Jahre", "waehrende", "Spontanregression", "mit", "der", "Aenderung", "des", "primaer", "monomorphen", "fibrozytischen", "hin", "zu", "einem", "polymorphen", "histiozytischen", "Aspekt", "mit", "zahlreichen", "fettspeichernden", "Riesenzellen", "sowie", "der", "fehlende", "Nachweis", "spezifischer", "Zellorganellen", "konnten", "die", "Natur", "der", "Erkrankung", "sichern", "." ]

[ "umlsterm" ]

juveniles Xanthogranulom, Diagnose, Riesenzellen, Natur

DerHautarzt.50460194.ger.abstr_task2

Sentence: Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O" ]

Zusammenfassung . Es wird ueber ein grossknotiges multizentrisches juveniles Xanthogranulom berichtet , dessen ungewoehnlicher klinischer und histologischer Aspekt die Diagnose anfaenglich nicht zuliess . Die inzwischen mehr als 2 Jahre waehrende Spontanregression mit der Aenderung des primaer monomorphen fibrozytischen hin zu einem polymorphen histiozytischen Aspekt mit zahlreichen fettspeichernden Riesenzellen sowie der fehlende Nachweis spezifischer Zellorganellen konnten die Natur der Erkrankung sichern .

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[ "umlsterm" ]

respiratory distress syndrome is an umlsterm, ARDS is an umlsterm, mortality rate is an umlsterm, trend is an umlsterm, survival rates is an umlsterm, inspiratory is an umlsterm, oxygen is an umlsterm, concentrations is an umlsterm, tidal volumes is an umlsterm, inspiratory is an umlsterm, pressures is an umlsterm, mechanical ventilation is an umlsterm, lung is an umlsterm, ARDS is an umlsterm, sequelae is an umlsterm, therapy is an umlsterm, Mechanical ventilation is an umlsterm, ARDS is an umlsterm, lung is an umlsterm, oxygen is an umlsterm, toxicity is an umlsterm, lung is an umlsterm, anatomical is an umlsterm, forms is an umlsterm, mechanical ventilation is an umlsterm, PEEP is an umlsterm, hypercapnia is an umlsterm, body position is an umlsterm, inhalation is an umlsterm, nitric oxide is an umlsterm, procedures is an umlsterm, gas is an umlsterm, extracorporeal membrane oxygenation is an umlsterm, therapeutic is an umlsterm, therapeutic procedures is an umlsterm, standard is an umlsterm, treatment is an umlsterm, randomised controlled trial is an umlsterm, review is an umlsterm, pathophysiology is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, ARDS is an umlsterm

DerAnaesthesist.60450002.eng.abstr_task0

Sentence: Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS .

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[ "umlsterm" ]

respiratory distress syndrome is an umlsterm, ARDS is an umlsterm, mortality rate is an umlsterm, trend is an umlsterm, survival rates is an umlsterm, inspiratory is an umlsterm, oxygen is an umlsterm, concentrations is an umlsterm, tidal volumes is an umlsterm, inspiratory is an umlsterm, pressures is an umlsterm, mechanical ventilation is an umlsterm, lung is an umlsterm, ARDS is an umlsterm, sequelae is an umlsterm, therapy is an umlsterm, Mechanical ventilation is an umlsterm, ARDS is an umlsterm, lung is an umlsterm, oxygen is an umlsterm, toxicity is an umlsterm, lung is an umlsterm, anatomical is an umlsterm, forms is an umlsterm, mechanical ventilation is an umlsterm, PEEP is an umlsterm, hypercapnia is an umlsterm, body position is an umlsterm, inhalation is an umlsterm, nitric oxide is an umlsterm, procedures is an umlsterm, gas is an umlsterm, extracorporeal membrane oxygenation is an umlsterm, therapeutic is an umlsterm, therapeutic procedures is an umlsterm, standard is an umlsterm, treatment is an umlsterm, randomised controlled trial is an umlsterm, review is an umlsterm, pathophysiology is an umlsterm, diagnosis is an umlsterm, treatment is an umlsterm, ARDS is an umlsterm

DerAnaesthesist.60450002.eng.abstr_task1

Sentence: Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS . Instructions: please typing these entity words according to sentence: respiratory distress syndrome, ARDS, mortality rate, trend, survival rates, inspiratory, oxygen, concentrations, tidal volumes, inspiratory, pressures, mechanical ventilation, lung, ARDS, sequelae, therapy, Mechanical ventilation, ARDS, lung, oxygen, toxicity, lung, anatomical, forms, mechanical ventilation, PEEP, hypercapnia, body position, inhalation, nitric oxide, procedures, gas, extracorporeal membrane oxygenation, therapeutic, therapeutic procedures, standard, treatment, randomised controlled trial, review, pathophysiology, diagnosis, treatment, ARDS Options: umlsterm

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Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS .

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[ "umlsterm" ]

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DerAnaesthesist.60450002.eng.abstr_task2

Sentence: Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS . Instructions: please extract entity words from the input sentence

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Acute respiratory distress syndrome ( ARDS ) is rare but beset with a high mortality rate . In recent years , however , a trend towards higher survival rates has been observed . High inspiratory oxygen concentrations , large tidal volumes , and high peak inspiratory airway pressures applied during mechanical ventilation have been identified as harmful to the lung and can contribute to the progression of ARDS . This had led to reconsideration of the sequelae of ventilatory therapy . Mechanical ventilation and other adjunctive strategies in ARDS have changed from the conventional approach aiming at normalisation of physiological ventilatory parameters to an elaborated approach that intends to protect the ventilated lung , prevent oxygen toxicity , recruit the infiltrated atelectatic and consolidated lung and reduce the anatomical and alveolar dead space . This new approach consists of various forms of pressure-controlled mechanical ventilation with PEEP and permissive hypercapnia , body position changes , and inhalation of nitric oxide . Should these procedures fail to improve impaired gas exchange , extracorporeal membrane oxygenation is an additional therapeutic option . None of these therapeutic procedures , however , has been tested against traditional standard treatment in a classical randomised controlled trial . The following review focuses on the latest insights into the pathophysiology , diagnosis , and treatment of ARDS .

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[ "umlsterm" ]

Mind training is a Intervention_Educational, children is a Participant_Age, autism : is a Outcome_Physical, Autism Spectrum Disorders ( ASD ) is a Participant_Condition, Theory of Mind ( ToM ) treatments is a Intervention_Educational, effectiveness is a Outcome_Other, ToM treatment is a Intervention_Educational, 8 - 13 year old children is a Participant_Age

47932_task0

Sentence: Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Condition, Intervention_Educational, Outcome_Physical, Participant_Age, Outcome_Other

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Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills .

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[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Outcome_Other", "Outcome_Physical" ]

Mind training is a Intervention_Educational, children is a Participant_Age, autism : is a Outcome_Physical, Autism Spectrum Disorders ( ASD ) is a Participant_Condition, Theory of Mind ( ToM ) treatments is a Intervention_Educational, effectiveness is a Outcome_Other, ToM treatment is a Intervention_Educational, 8 - 13 year old children is a Participant_Age

47932_task1

Sentence: Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills . Instructions: please typing these entity words according to sentence: Mind training, children, autism :, Autism Spectrum Disorders ( ASD ), Theory of Mind ( ToM ) treatments, effectiveness, ToM treatment, 8 - 13 year old children Options: Participant_Condition, Intervention_Educational, Outcome_Physical, Participant_Age, Outcome_Other

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Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills .

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[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Outcome_Other", "Outcome_Physical" ]

Mind training, children, autism :, Autism Spectrum Disorders ( ASD ), Theory of Mind ( ToM ) treatments, effectiveness, ToM treatment, 8 - 13 year old children

47932_task2

Sentence: Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills . Instructions: please extract entity words from the input sentence

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Theory of Mind training in children with autism : a randomized controlled trial . Many children with Autism Spectrum Disorders ( ASD ) participate in social skills or Theory of Mind ( ToM ) treatments . However , few studies have shown evidence for their effectiveness . The current study used a randomized controlled design to test the effectiveness of a 16-week ToM treatment in 8-13 year old children with ASD and normal IQs ( n = 40 ) . The results showed that , compared to controls , the treated children with ASD improved in their conceptual ToM skills , but their elementary understanding , self reported empathic skills or parent reported social behaviour did not improve . Despite the effects on conceptual understanding , the current study does not indicate strong evidence for the effectiveness of a ToM treatment on the daily life mindreading skills .

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[ "Intervention_Educational", "Participant_Condition", "Participant_Age", "Outcome_Other", "Outcome_Physical" ]

Erbium is an umlsterm, laser is an umlsterm, sclerostomy is an umlsterm, glaucoma is an umlsterm, surgery is an umlsterm, date is an umlsterm, method is an umlsterm, trabeculectomy is an umlsterm, cause is an umlsterm, therapy is an umlsterm, postoperative is an umlsterm, bleb is an umlsterm, aim is an umlsterm, complication is an umlsterm

DerOpthalmologe.60930569.eng.abstr_task0

Sentence: Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

[ "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication .

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[ "umlsterm" ]

Erbium is an umlsterm, laser is an umlsterm, sclerostomy is an umlsterm, glaucoma is an umlsterm, surgery is an umlsterm, date is an umlsterm, method is an umlsterm, trabeculectomy is an umlsterm, cause is an umlsterm, therapy is an umlsterm, postoperative is an umlsterm, bleb is an umlsterm, aim is an umlsterm, complication is an umlsterm

DerOpthalmologe.60930569.eng.abstr_task1

Sentence: Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication . Instructions: please typing these entity words according to sentence: Erbium, laser, sclerostomy, glaucoma, surgery, date, method, trabeculectomy, cause, therapy, postoperative, bleb, aim, complication Options: umlsterm

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Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication .

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[ "umlsterm" ]

Erbium, laser, sclerostomy, glaucoma, surgery, date, method, trabeculectomy, cause, therapy, postoperative, bleb, aim, complication

DerOpthalmologe.60930569.eng.abstr_task2

Sentence: Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication . Instructions: please extract entity words from the input sentence

[ "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]

Background : Erbium laser sclerostomy ( ELS ) ab externo is a minimally invasive addition to conventional fistulating glaucoma surgery . To date , the success rate of this method is lower than that of trabeculectomy or goniotrepanation . The chief cause of therapy failure is postoperative episcleral scarring of the bleb . It was the aim of the present study to decrease the occlusion rate of this complication .

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[ "umlsterm" ]

Gewebevertraeglichkeit is an umlsterm, Ratten is an umlsterm, in vitro is an umlsterm, Peritoneum is an umlsterm, Versuchstier is an umlsterm, Lavage is an umlsterm, Langzeitanwendung is an umlsterm, Peritonealspuelung is an umlsterm, Spuelung is an umlsterm, Ethanol is an umlsterm

DerChirurg.80690840.ger.abstr_task0

Sentence: Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika .

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[ "umlsterm" ]

Gewebevertraeglichkeit is an umlsterm, Ratten is an umlsterm, in vitro is an umlsterm, Peritoneum is an umlsterm, Versuchstier is an umlsterm, Lavage is an umlsterm, Langzeitanwendung is an umlsterm, Peritonealspuelung is an umlsterm, Spuelung is an umlsterm, Ethanol is an umlsterm

DerChirurg.80690840.ger.abstr_task1

Sentence: Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika . Instructions: please typing these entity words according to sentence: Gewebevertraeglichkeit, Ratten, in vitro, Peritoneum, Versuchstier, Lavage, Langzeitanwendung, Peritonealspuelung, Spuelung, Ethanol Options: umlsterm

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Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika .

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[ "umlsterm" ]

Gewebevertraeglichkeit, Ratten, in vitro, Peritoneum, Versuchstier, Lavage, Langzeitanwendung, Peritonealspuelung, Spuelung, Ethanol

DerChirurg.80690840.ger.abstr_task2

Sentence: Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika . Instructions: please extract entity words from the input sentence

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Zusammenfassung . Als sensitive Screeningmethode zur Ermittlung der Gewebevertraeglichkeit lokaler Wundantiinfektiva eignet sich die Kultivierung von Peritonealexplantaten neonataler Ratten in vitro nach vorheriger Substanzeinwirkung zur Simulierung der Wundantiseptik . Es werden 2 Pruefmodelle unterschieden : ( 1 separierte Peritonealexplantate ) als Modell fuer chronische bzw. tiefe Wunden und ( 2 Peritoneum ) in situ am Versuchstier mit anschliessender Explantatgewinnung und -kultivierung . Unter Beruecksichtigung des aktuellen Wissensstandes lassen sich folgende Schlussfolgerungen zur Wundantiseptik ableiten : Lavasept ist 0,1 %ig als Wirkstoff der Wahl fuer tiefe bzw. chronische Wunden , zur Spuel-Saug-Drainage und zur antiinfektiven Lavage von Koerperhoehlen einschliesslich Bauchhoehle ( 0,05 % ) einzuordnen . Bei Langzeitanwendung ( > 6 Std ) ist auch Taurolidin antiseptisch effektiv und durch seine antitoxische Wirkung sowie fehlende Cytotoxizitaet speziell zur Peritonealspuelung praedestiniert . Betaisodona-Loesung ist fuer oberflaechliche kontaminierte Wunden geeignet , kann aber 1 10 : verduennt auch zur kurzfristigen Spuelung tiefer Wunden einschliesslich Koerperhoehlen mit Ausnahme der Bauchhoehle angewendet werden . Ethanol verursacht keine Explantathemmung und hat daher nach wie vor seine Bedeutung in Wundantiseptika .

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[ "umlsterm" ]

Zaire is an umlsterm, Aids is an umlsterm, CDC is an umlsterm, molluscum contagiosum infection is an umlsterm, cryptococcosis is an umlsterm, cryptosporidiosis is an umlsterm, molluscum contagiosum infection is an umlsterm, disease is an umlsterm, persons is an umlsterm, giant is an umlsterm, mollusca is an umlsterm, immunodeficiency is an umlsterm, T cell is an umlsterm, populations is an umlsterm, infection is an umlsterm, cryptococcosis is an umlsterm, differential diagnosis is an umlsterm, differential diagnoses is an umlsterm, histoplasmosis is an umlsterm, mycobacterial infections is an umlsterm, toxoplasmosis is an umlsterm, Pneumocystis carinii infection is an umlsterm

DerHautarzt.50460799.eng.abstr_task0

Sentence: A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection .

[ "A", "12-year", "-", "old", "girl", "from", "Zaire", "with", "Aids", "(", "CDC", ":", "P2", "D1", ")", "presented", "with", "a", "generalized", "molluscum", "contagiosum", "infection", ".", "She", "had", "suffered", "from", "systemic", "cryptococcosis", "and", "from", "cryptosporidiosis", "several", "months", "before", "admission", ".", "While", "molluscum", "contagiosum", "infection", "is", "usually", "a", "self", "-", "limiting", "disease", "in", "immunocompetent", "persons", ",", "a", "fulminant", "appearance", "and", "persistence", "of", "giant", "mollusca", "occurs", "with", "advanced", "immunodeficiency", ".", "Histological", "and", "immunohistological", "examinations", "showed", "a", "severe", "diminution", "of", "Langerhans", "and", "T", "cell", "populations", "that", "might", "enhance", "the", "dissemination", "of", "the", "infection", ".", "Molluscum", "-", "like", "lesions", "of", "cryptococci", "have", "been", "described", ",", "and", "cutaneous", "cryptococcosis", "is", "the", "main", "condition", "to", "be", "considered", "in", "the", "differential", "diagnosis", ".", "Further", "differential", "diagnoses", "should", "include", "American", "and", "African", "histoplasmosis", ",", "and", "the", "cutaneous", "manifestations", "of", "mycobacterial", "infections", ",", "of", "toxoplasmosis", "and", "of", "Pneumocystis", "carinii", "infection", "." ]

[ "umlsterm" ]

Zaire is an umlsterm, Aids is an umlsterm, CDC is an umlsterm, molluscum contagiosum infection is an umlsterm, cryptococcosis is an umlsterm, cryptosporidiosis is an umlsterm, molluscum contagiosum infection is an umlsterm, disease is an umlsterm, persons is an umlsterm, giant is an umlsterm, mollusca is an umlsterm, immunodeficiency is an umlsterm, T cell is an umlsterm, populations is an umlsterm, infection is an umlsterm, cryptococcosis is an umlsterm, differential diagnosis is an umlsterm, differential diagnoses is an umlsterm, histoplasmosis is an umlsterm, mycobacterial infections is an umlsterm, toxoplasmosis is an umlsterm, Pneumocystis carinii infection is an umlsterm

DerHautarzt.50460799.eng.abstr_task1

Sentence: A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection . Instructions: please typing these entity words according to sentence: Zaire, Aids, CDC, molluscum contagiosum infection, cryptococcosis, cryptosporidiosis, molluscum contagiosum infection, disease, persons, giant, mollusca, immunodeficiency, T cell, populations, infection, cryptococcosis, differential diagnosis, differential diagnoses, histoplasmosis, mycobacterial infections, toxoplasmosis, Pneumocystis carinii infection Options: umlsterm

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]

A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection .

[ "A", "12-year", "-", "old", "girl", "from", "Zaire", "with", "Aids", "(", "CDC", ":", "P2", "D1", ")", "presented", "with", "a", "generalized", "molluscum", "contagiosum", "infection", ".", "She", "had", "suffered", "from", "systemic", "cryptococcosis", "and", "from", "cryptosporidiosis", "several", "months", "before", "admission", ".", "While", "molluscum", "contagiosum", "infection", "is", "usually", "a", "self", "-", "limiting", "disease", "in", "immunocompetent", "persons", ",", "a", "fulminant", "appearance", "and", "persistence", "of", "giant", "mollusca", "occurs", "with", "advanced", "immunodeficiency", ".", "Histological", "and", "immunohistological", "examinations", "showed", "a", "severe", "diminution", "of", "Langerhans", "and", "T", "cell", "populations", "that", "might", "enhance", "the", "dissemination", "of", "the", "infection", ".", "Molluscum", "-", "like", "lesions", "of", "cryptococci", "have", "been", "described", ",", "and", "cutaneous", "cryptococcosis", "is", "the", "main", "condition", "to", "be", "considered", "in", "the", "differential", "diagnosis", ".", "Further", "differential", "diagnoses", "should", "include", "American", "and", "African", "histoplasmosis", ",", "and", "the", "cutaneous", "manifestations", "of", "mycobacterial", "infections", ",", "of", "toxoplasmosis", "and", "of", "Pneumocystis", "carinii", "infection", "." ]

[ "umlsterm" ]

Zaire, Aids, CDC, molluscum contagiosum infection, cryptococcosis, cryptosporidiosis, molluscum contagiosum infection, disease, persons, giant, mollusca, immunodeficiency, T cell, populations, infection, cryptococcosis, differential diagnosis, differential diagnoses, histoplasmosis, mycobacterial infections, toxoplasmosis, Pneumocystis carinii infection

DerHautarzt.50460799.eng.abstr_task2

Sentence: A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]

A 12-year-old girl from Zaire with Aids ( CDC : P2 D1) presented with a generalized molluscum contagiosum infection . She had suffered from systemic cryptococcosis and from cryptosporidiosis several months before admission . While molluscum contagiosum infection is usually a self-limiting disease in immunocompetent persons , a fulminant appearance and persistence of giant mollusca occurs with advanced immunodeficiency . Histological and immunohistological examinations showed a severe diminution of Langerhans and T cell populations that might enhance the dissemination of the infection . Molluscum-like lesions of cryptococci have been described , and cutaneous cryptococcosis is the main condition to be considered in the differential diagnosis . Further differential diagnoses should include American and African histoplasmosis , and the cutaneous manifestations of mycobacterial infections , of toxoplasmosis and of Pneumocystis carinii infection .

[ "A", "12-year", "-", "old", "girl", "from", "Zaire", "with", "Aids", "(", "CDC", ":", "P2", "D1", ")", "presented", "with", "a", "generalized", "molluscum", "contagiosum", "infection", ".", "She", "had", "suffered", "from", "systemic", "cryptococcosis", "and", "from", "cryptosporidiosis", "several", "months", "before", "admission", ".", "While", "molluscum", "contagiosum", "infection", "is", "usually", "a", "self", "-", "limiting", "disease", "in", "immunocompetent", "persons", ",", "a", "fulminant", "appearance", "and", "persistence", "of", "giant", "mollusca", "occurs", "with", "advanced", "immunodeficiency", ".", "Histological", "and", "immunohistological", "examinations", "showed", "a", "severe", "diminution", "of", "Langerhans", "and", "T", "cell", "populations", "that", "might", "enhance", "the", "dissemination", "of", "the", "infection", ".", "Molluscum", "-", "like", "lesions", "of", "cryptococci", "have", "been", "described", ",", "and", "cutaneous", "cryptococcosis", "is", "the", "main", "condition", "to", "be", "considered", "in", "the", "differential", "diagnosis", ".", "Further", "differential", "diagnoses", "should", "include", "American", "and", "African", "histoplasmosis", ",", "and", "the", "cutaneous", "manifestations", "of", "mycobacterial", "infections", ",", "of", "toxoplasmosis", "and", "of", "Pneumocystis", "carinii", "infection", "." ]

[ "umlsterm" ]

Rb is a protein, p107 is a protein, p130 is a protein, E2F target promoters is a DNA

1.0alpha7.train.60_task0

Sentence: E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49). Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA, protein

[ "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O" ]

E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49).

[ "E2Fs", "bind", "directly", "to", "Rb", ",", "p107", ",", "and", "p130", ",", "and", "we", "have", "previously", "shown", "that", "these", "proteins", "are", "components", "of", "the", "transcription", "complexes", "formed", "on", "E2F", "target", "promoters", "in", "vivo", "(", "49", ")", "." ]

[ "DNA", "protein", "protein-family" ]

Rb is a protein, p107 is a protein, p130 is a protein, E2F target promoters is a DNA

1.0alpha7.train.60_task1

Sentence: E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49). Instructions: please typing these entity words according to sentence: Rb, p107, p130, E2F target promoters Options: DNA, protein

[ "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O" ]

E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49).

[ "E2Fs", "bind", "directly", "to", "Rb", ",", "p107", ",", "and", "p130", ",", "and", "we", "have", "previously", "shown", "that", "these", "proteins", "are", "components", "of", "the", "transcription", "complexes", "formed", "on", "E2F", "target", "promoters", "in", "vivo", "(", "49", ")", "." ]

[ "DNA", "protein", "protein-family" ]

Rb, p107, p130, E2F target promoters

1.0alpha7.train.60_task2

Sentence: E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49). Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "B-protein", "O", "B-protein", "O", "O", "B-protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-DNA", "I-DNA", "I-DNA", "O", "O", "O", "O", "O", "O" ]

E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49).

[ "E2Fs", "bind", "directly", "to", "Rb", ",", "p107", ",", "and", "p130", ",", "and", "we", "have", "previously", "shown", "that", "these", "proteins", "are", "components", "of", "the", "transcription", "complexes", "formed", "on", "E2F", "target", "promoters", "in", "vivo", "(", "49", ")", "." ]

[ "DNA", "protein", "protein-family" ]

repressor / activator is an other_name, NF - E1 is a protein_molecule, YY-1 is a protein_molecule, delta is a protein_molecule, immunoglobulin kappa 3 ' enhancer is a DNA_domain_or_region, immunoglobulin heavy - chain mu E1 site is a DNA_domain_or_region

91080_task0

Sentence: Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: DNA_domain_or_region, protein_molecule, other_name

[ "O", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.

[ "Isolation", "of", "a", "candidate", "repressor", "/", "activator", ",", "NF", "-", "E1", "(", "YY-1", ",", "delta", ")", ",", "that", "binds", "to", "the", "immunoglobulin", "kappa", "3", "'", "enhancer", "and", "the", "immunoglobulin", "heavy", "-", "chain", "mu", "E1", "site", "." ]

[ "DNA_domain_or_region", "protein_family_or_group", "other_name", "protein_molecule", "DNA_molecule", "protein_N/A", "DNA_family_or_group" ]

repressor / activator is an other_name, NF - E1 is a protein_molecule, YY-1 is a protein_molecule, delta is a protein_molecule, immunoglobulin kappa 3 ' enhancer is a DNA_domain_or_region, immunoglobulin heavy - chain mu E1 site is a DNA_domain_or_region

91080_task1

Sentence: Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. Instructions: please typing these entity words according to sentence: repressor / activator, NF - E1, YY-1, delta, immunoglobulin kappa 3 ' enhancer, immunoglobulin heavy - chain mu E1 site Options: DNA_domain_or_region, protein_molecule, other_name

[ "O", "O", "O", "O", "B-other_name", "I-other_name", "I-other_name", "O", "B-protein_molecule", "I-protein_molecule", "I-protein_molecule", "O", "B-protein_molecule", "O", "B-protein_molecule", "O", "O", "O", "O", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O", "O", "B-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "I-DNA_domain_or_region", "O" ]

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.

[ "Isolation", "of", "a", "candidate", "repressor", "/", "activator", ",", "NF", "-", "E1", "(", "YY-1", ",", "delta", ")", ",", "that", "binds", "to", "the", "immunoglobulin", "kappa", "3", "'", "enhancer", "and", "the", "immunoglobulin", "heavy", "-", "chain", "mu", "E1", "site", "." ]

[ "DNA_domain_or_region", "protein_family_or_group", "other_name", "protein_molecule", "DNA_molecule", "protein_N/A", "DNA_family_or_group" ]