bio-datasets/bigbio-ner-merged · Datasets at Hugging Face

answer stringlengths 1 16.1k	id stringlengths 7 56	instruction stringlengths 106 72.6k	ner_tags list	text stringlengths 5 72.4k	tokens list	types list
Individuals with ASD is a participant, metaphor is an intervention	490_task1	Sentence: Individuals with ASD performed at greater than chance levels on both metaphor types , although their performance was lower than TD participants . Instructions: please typing these entity words according to sentence: Individuals with ASD, metaphor Options: intervention, participant	[ "B-participant", "I-participant", "I-participant", "O", "O", "O", "O", "O", "O", "O", "O", "B-intervention", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Individuals with ASD performed at greater than chance levels on both metaphor types , although their performance was lower than TD participants .	[ "Individuals", "with", "ASD", "performed", "at", "greater", "than", "chance", "levels", "on", "both", "metaphor", "types", ",", "although", "their", "performance", "was", "lower", "than", "TD", "participants", "." ]	[ "participant", "intervention", "outcome" ]
Individuals with ASD, metaphor	490_task2	Sentence: Individuals with ASD performed at greater than chance levels on both metaphor types , although their performance was lower than TD participants . Instructions: please extract entity words from the input sentence	[ "B-participant", "I-participant", "I-participant", "O", "O", "O", "O", "O", "O", "O", "O", "B-intervention", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Individuals with ASD performed at greater than chance levels on both metaphor types , although their performance was lower than TD participants .	[ "Individuals", "with", "ASD", "performed", "at", "greater", "than", "chance", "levels", "on", "both", "metaphor", "types", ",", "although", "their", "performance", "was", "lower", "than", "TD", "participants", "." ]	[ "participant", "intervention", "outcome" ]
Internal mammary artery is an umlsterm, grafts is an umlsterm, blood supply is an umlsterm, myocardium is an umlsterm, myocardial ischemia is an umlsterm, surgical is an umlsterm, method is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm, measurement is an umlsterm, heart is an umlsterm, reperfusion is an umlsterm, cardioplegia is an umlsterm, patients is an umlsterm, multi - vessel is an umlsterm, coronary artery disease is an umlsterm, coronary artery bypass is an umlsterm, grafting is an umlsterm, graft is an umlsterm, anterior is an umlsterm, artery is an umlsterm, saphenous vein is an umlsterm, grafts is an umlsterm, arteries is an umlsterm, cold is an umlsterm, aorta is an umlsterm, graft is an umlsterm, temperatures is an umlsterm, reperfusion is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm, rewarming is an umlsterm, speed is an umlsterm, derivative is an umlsterm, temperature is an umlsterm, time is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm	ZfuerHerzThoraxGefaesschirurgie.00140070.eng.abstr_task0	Sentence: Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses .	[ "Internal", "mammary", "artery", "(", "IMA", ")", "bypass", "grafts", "have", "a", "satisfactorily", "long", "lasting", "blood", "supply", "to", "the", "myocardium", ".", "Their", "initial", "flow", "capacity", "can", "be", "insufficient", "with", "subsequent", "regional", "myocardial", "ischemia", ".", "This", "study", "represents", "a", "feasable", "surgical", "method", "to", "evaluate", "the", "effectiveness", "of", "the", "IMA", "graft", "function", "by", "temperature", "measurement", "of", "the", "heart", "during", "warm", "reperfusion", "after", "hypothermic", "cardioplegia", ".", "Twenty", "-", "five", "patients", "with", "multi", "-", "vessel", "coronary", "artery", "disease", "underwent", "coronary", "artery", "bypass", "grafting", "using", "the", "IMA", "as", "an", "arterial", "graft", "to", "the", "left", "anterior", "descending", "coronary", "artery", "and", "saphenous", "vein", "grafts", "to", "the", "remaining", "coronary", "arteries", ".", "Distal", "anastomoses", "were", "installed", "during", "cold", "intermittent", "blood", "-", "cardioplegic", "arrest", ".", "After", "unclamping", "the", "aorta", "and", "IMA", "graft", ",", "the", "temperatures", "in", "cardiac", "front", "and", "rear", "sides", "were", "measured", "during", "the", "first", "five", "minutes", "of", "warm", "reperfusion", ".", "A", "sufficient", "IMA", "graft", "function", "was", "expressed", "by", "a", "typical", "rise", "of", "temperature", ":", "The", "cardiac", "front", "and", "rear", "sides", "showed", "a", "parabolic", "and", "exponential", "course", ",", "respectively", ".", "The", "rewarming", "speed", "expressed", "as", "the", "first", "derivative", "of", "temperature", "over", "time", "led", "to", "a", "sharp", "and", "early", "peak", "for", "the", "front", "side", ",", "and", "a", "smaller", "and", "delayed", "peak", "for", "the", "rear", "side", ".", "An", "insufficient", "IMA", "graft", "function", "could", "be", "recognized", "by", "atypical", "temperature", "courses", "." ]	[ "umlsterm" ]
Internal mammary artery is an umlsterm, grafts is an umlsterm, blood supply is an umlsterm, myocardium is an umlsterm, myocardial ischemia is an umlsterm, surgical is an umlsterm, method is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm, measurement is an umlsterm, heart is an umlsterm, reperfusion is an umlsterm, cardioplegia is an umlsterm, patients is an umlsterm, multi - vessel is an umlsterm, coronary artery disease is an umlsterm, coronary artery bypass is an umlsterm, grafting is an umlsterm, graft is an umlsterm, anterior is an umlsterm, artery is an umlsterm, saphenous vein is an umlsterm, grafts is an umlsterm, arteries is an umlsterm, cold is an umlsterm, aorta is an umlsterm, graft is an umlsterm, temperatures is an umlsterm, reperfusion is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm, rewarming is an umlsterm, speed is an umlsterm, derivative is an umlsterm, temperature is an umlsterm, time is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm	ZfuerHerzThoraxGefaesschirurgie.00140070.eng.abstr_task1	Sentence: Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses . Instructions: please typing these entity words according to sentence: Internal mammary artery, grafts, blood supply, myocardium, myocardial ischemia, surgical, method, graft, function, temperature, measurement, heart, reperfusion, cardioplegia, patients, multi - vessel, coronary artery disease, coronary artery bypass, grafting, graft, anterior, artery, saphenous vein, grafts, arteries, cold, aorta, graft, temperatures, reperfusion, graft, function, temperature, rewarming, speed, derivative, temperature, time, graft, function, temperature Options: umlsterm	[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses .	[ "Internal", "mammary", "artery", "(", "IMA", ")", "bypass", "grafts", "have", "a", "satisfactorily", "long", "lasting", "blood", "supply", "to", "the", "myocardium", ".", "Their", "initial", "flow", "capacity", "can", "be", "insufficient", "with", "subsequent", "regional", "myocardial", "ischemia", ".", "This", "study", "represents", "a", "feasable", "surgical", "method", "to", "evaluate", "the", "effectiveness", "of", "the", "IMA", "graft", "function", "by", "temperature", "measurement", "of", "the", "heart", "during", "warm", "reperfusion", "after", "hypothermic", "cardioplegia", ".", "Twenty", "-", "five", "patients", "with", "multi", "-", "vessel", "coronary", "artery", "disease", "underwent", "coronary", "artery", "bypass", "grafting", "using", "the", "IMA", "as", "an", "arterial", "graft", "to", "the", "left", "anterior", "descending", "coronary", "artery", "and", "saphenous", "vein", "grafts", "to", "the", "remaining", "coronary", "arteries", ".", "Distal", "anastomoses", "were", "installed", "during", "cold", "intermittent", "blood", "-", "cardioplegic", "arrest", ".", "After", "unclamping", "the", "aorta", "and", "IMA", "graft", ",", "the", "temperatures", "in", "cardiac", "front", "and", "rear", "sides", "were", "measured", "during", "the", "first", "five", "minutes", "of", "warm", "reperfusion", ".", "A", "sufficient", "IMA", "graft", "function", "was", "expressed", "by", "a", "typical", "rise", "of", "temperature", ":", "The", "cardiac", "front", "and", "rear", "sides", "showed", "a", "parabolic", "and", "exponential", "course", ",", "respectively", ".", "The", "rewarming", "speed", "expressed", "as", "the", "first", "derivative", "of", "temperature", "over", "time", "led", "to", "a", "sharp", "and", "early", "peak", "for", "the", "front", "side", ",", "and", "a", "smaller", "and", "delayed", "peak", "for", "the", "rear", "side", ".", "An", "insufficient", "IMA", "graft", "function", "could", "be", "recognized", "by", "atypical", "temperature", "courses", "." ]	[ "umlsterm" ]
Internal mammary artery, grafts, blood supply, myocardium, myocardial ischemia, surgical, method, graft, function, temperature, measurement, heart, reperfusion, cardioplegia, patients, multi - vessel, coronary artery disease, coronary artery bypass, grafting, graft, anterior, artery, saphenous vein, grafts, arteries, cold, aorta, graft, temperatures, reperfusion, graft, function, temperature, rewarming, speed, derivative, temperature, time, graft, function, temperature	ZfuerHerzThoraxGefaesschirurgie.00140070.eng.abstr_task2	Sentence: Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses . Instructions: please extract entity words from the input sentence	[ "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses .	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exercise is a Intervention_Physical, bone health is a Outcome_Physical, Exercise is a Intervention_Physical, bone strength is a Outcome_Physical, Brief , high - impact exercise is a Intervention_Physical, femoral neck bone density is a Outcome_Physical, femoral neck BMD is a Outcome_Physical, whether BMD change differed between hip sites is a Outcome_Physical, premenopausal women is a Participant_Condition, exercise intervention is a Intervention_Physical, bone changes is a Outcome_Physical, Peak ground reaction forces is a Outcome_Physical, change in femoral neck BMD is a Outcome_Physical, BMD changes at upper neck , lower neck and trochanter is a Outcome_Physical, exercises is a Intervention_Physical, Brief high - impact exercise is a Intervention_Physical, hip fragility is a Outcome_Physical	43331_task0	Sentence: Optimum frequency of exercise for bone health : randomised controlled trial of a high-impact unilateral intervention . INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response . 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INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response .	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exercise is a Intervention_Physical, bone health is a Outcome_Physical, Exercise is a Intervention_Physical, bone strength is a Outcome_Physical, Brief , high - impact exercise is a Intervention_Physical, femoral neck bone density is a Outcome_Physical, femoral neck BMD is a Outcome_Physical, whether BMD change differed between hip sites is a Outcome_Physical, premenopausal women is a Participant_Condition, exercise intervention is a Intervention_Physical, bone changes is a Outcome_Physical, Peak ground reaction forces is a Outcome_Physical, change in femoral neck BMD is a Outcome_Physical, BMD changes at upper neck , lower neck and trochanter is a Outcome_Physical, exercises is a Intervention_Physical, Brief high - impact exercise is a Intervention_Physical, hip fragility is a Outcome_Physical	43331_task1	Sentence: Optimum frequency of exercise for bone health : randomised controlled trial of a high-impact unilateral intervention . INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response . Instructions: please typing these entity words according to sentence: exercise, bone health, Exercise, bone strength, Brief , high - impact exercise, femoral neck bone density, femoral neck BMD, whether BMD change differed between hip sites, premenopausal women, exercise intervention, bone changes, Peak ground reaction forces, change in femoral neck BMD, BMD changes at upper neck , lower neck and trochanter, exercises, Brief high - impact exercise, hip fragility Options: Intervention_Physical, Outcome_Physical, Participant_Condition	[ "O", "O", "O", "B-Intervention_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "I-Intervention_Physical", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Optimum frequency of exercise for bone health : randomised controlled trial of a high-impact unilateral intervention . INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response .	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exercise, bone health, Exercise, bone strength, Brief , high - impact exercise, femoral neck bone density, femoral neck BMD, whether BMD change differed between hip sites, premenopausal women, exercise intervention, bone changes, Peak ground reaction forces, change in femoral neck BMD, BMD changes at upper neck , lower neck and trochanter, exercises, Brief high - impact exercise, hip fragility	43331_task2	Sentence: Optimum frequency of exercise for bone health : randomised controlled trial of a high-impact unilateral intervention . INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response . 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INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response .	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prospective study is an umlsterm, patients is an umlsterm, myocardial infarction is an umlsterm, risk is an umlsterm, sudden cardiac death is an umlsterm, patients is an umlsterm, follow - up - period is an umlsterm	ZfuerKardiologie.70860883.eng.abstr_task0	Sentence: A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period .	[ "A", "prospective", "study", "was", "performed", "of", "the", "correlation", "of", "ventricular", "late", "potentials", "(", "LP", ")", "and", "clinical", "parameters", "in", "patients", "after", "acute", "myocardial", "infarction", ".", "To", "evaluate", "the", "prognostic", "significance", "of", "the", "signalaveraged", "-", "electrocardiogram", "(", "SAECG", ")", "in", "risk", "stratification", "of", "sudden", "cardiac", "death", "and", "arrhythmogenic", "events", ",", "the", "clinical", "characteristics", "of", "these", "postinfarction", "patients", "were", "performed", "in", "a", "follow", "-", "up", "-", "period", "." ]	[ "umlsterm" ]
prospective study is an umlsterm, patients is an umlsterm, myocardial infarction is an umlsterm, risk is an umlsterm, sudden cardiac death is an umlsterm, patients is an umlsterm, follow - up - period is an umlsterm	ZfuerKardiologie.70860883.eng.abstr_task1	Sentence: A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period . Instructions: please typing these entity words according to sentence: prospective study, patients, myocardial infarction, risk, sudden cardiac death, patients, follow - up - period Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period .	[ "A", "prospective", "study", "was", "performed", "of", "the", "correlation", "of", "ventricular", "late", "potentials", "(", "LP", ")", "and", "clinical", "parameters", "in", "patients", "after", "acute", "myocardial", "infarction", ".", "To", "evaluate", "the", "prognostic", "significance", "of", "the", "signalaveraged", "-", "electrocardiogram", "(", "SAECG", ")", "in", "risk", "stratification", "of", "sudden", "cardiac", "death", "and", "arrhythmogenic", "events", ",", "the", "clinical", "characteristics", "of", "these", "postinfarction", "patients", "were", "performed", "in", "a", "follow", "-", "up", "-", "period", "." ]	[ "umlsterm" ]
prospective study, patients, myocardial infarction, risk, sudden cardiac death, patients, follow - up - period	ZfuerKardiologie.70860883.eng.abstr_task2	Sentence: A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period .	[ "A", "prospective", "study", "was", "performed", "of", "the", "correlation", "of", "ventricular", "late", "potentials", "(", "LP", ")", "and", "clinical", "parameters", "in", "patients", "after", "acute", "myocardial", "infarction", ".", "To", "evaluate", "the", "prognostic", "significance", "of", "the", "signalaveraged", "-", "electrocardiogram", "(", "SAECG", ")", "in", "risk", "stratification", "of", "sudden", "cardiac", "death", "and", "arrhythmogenic", "events", ",", "the", "clinical", "characteristics", "of", "these", "postinfarction", "patients", "were", "performed", "in", "a", "follow", "-", "up", "-", "period", "." ]	[ "umlsterm" ]
Komplikation is an umlsterm, Patienten is an umlsterm, Spezifitaet is an umlsterm, Ultraschalldiagnostik is an umlsterm, Ultraschallkriterien is an umlsterm, Patienten is an umlsterm, Ultraschalluntersuchung is an umlsterm, parenterale Ernaehrung is an umlsterm, Patienten is an umlsterm, Gallenblasenwand is an umlsterm, Gallenblasenwand is an umlsterm, Diagnose is an umlsterm, Sonographiebefund is an umlsterm	DerChirurg.70680898.ger.abstr_task0	Sentence: Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden .	[ "Zusammenfassung", ".", "Eine", "oft", "unbemerkte", "jedoch", "potentiell", "fatale", "Komplikation", ",", "im", "posttraumatischen", "Verlauf", "intensivpflichtiger", "Patienten", "ist", "die", "reaktive", "akute", "Cholecystitis", ".", "Aufgrund", "der", "hohen", "Spezifitaet", "der", "Ultraschalldiagnostik", "im", "biliaeren", "System", "war", "es", "unser", "Ziel", ",", "die", "Ultraschallkriterien", "zur", "fruehzeitigen", "Objektivierung", "der", "posttraumatischen", "Cholecystitis", "zu", "ueberpruefen", ".", "Prospektiv", "wurde", "ueber", "12", "Monate", "bei", "40", "beatmungspflichtigen", "Patienten", "an", "jeweils", "7", "Tagen", "eine", "Ultraschalluntersuchung", "des", "Oberbauchs", "durchgefuehrt", ".", "Die", "Ergebnisse", "zeigen", ",", "dass", "Beatmung", "parenterale", "Ernaehrung", "und", "die", "Auswirkungen", ",", "einer", "zuvor", "stattgehabten", "Traumatisierung", "des", "Patienten", "zu", "einer", "verzoegerten", "Verdickung", "(", "28/40", ")", "bzw", ".", "Dreischichtung", "(", "9/40", ")", "der", "Gallenblasenwand", "fuehren", "kann", ".", "Sonographisch", "waren", "in", "22,5", "%", "(", "9/40", ")", "die", "Zeichen", "einer", "akuten", "Cholecystitis", "nachweisbar", ".", "In", "Korrelation", "mit", "den", "klinischen", "Parametern", "ergab", "sich", "jedoch", "nur", "in", "2", "Faellen", "die", "Indikation", "zur", "Cholecystektomie", ".", "Unsere", "Studie", "zeigt", ",", "dass", "das", "morphologische", "Korrelat", "einer", "verdickten", "dreischichtigen", "Gallenblasenwand", "auch", "ohne", "zugrundeliegende", "Cholecystitis", "im", "Rahmen", "systemischer", "Veraenderungen", "auftreten", "kann", ".", "Eine", "sichere", "Diagnose", "einer", "akuten", "reaktiven", "Cholecystitis", "mit", "der", "Indikation", "zur", "Cholecystektomie", "konnte", "bei", "pathologischem", "Sonographiebefund", "nur", "in", "enger", "Korrelation", "mit", "klinischen", "Parametern", "gestellt", "werden", "." ]	[ "umlsterm" ]
Komplikation is an umlsterm, Patienten is an umlsterm, Spezifitaet is an umlsterm, Ultraschalldiagnostik is an umlsterm, Ultraschallkriterien is an umlsterm, Patienten is an umlsterm, Ultraschalluntersuchung is an umlsterm, parenterale Ernaehrung is an umlsterm, Patienten is an umlsterm, Gallenblasenwand is an umlsterm, Gallenblasenwand is an umlsterm, Diagnose is an umlsterm, Sonographiebefund is an umlsterm	DerChirurg.70680898.ger.abstr_task1	Sentence: Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden . Instructions: please typing these entity words according to sentence: Komplikation, Patienten, Spezifitaet, Ultraschalldiagnostik, Ultraschallkriterien, Patienten, Ultraschalluntersuchung, parenterale Ernaehrung, Patienten, Gallenblasenwand, Gallenblasenwand, Diagnose, Sonographiebefund Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden .	[ "Zusammenfassung", ".", "Eine", "oft", "unbemerkte", "jedoch", "potentiell", "fatale", "Komplikation", ",", "im", "posttraumatischen", "Verlauf", "intensivpflichtiger", "Patienten", "ist", "die", "reaktive", "akute", "Cholecystitis", ".", "Aufgrund", "der", "hohen", "Spezifitaet", "der", "Ultraschalldiagnostik", "im", "biliaeren", "System", "war", "es", "unser", "Ziel", ",", "die", "Ultraschallkriterien", "zur", "fruehzeitigen", "Objektivierung", "der", "posttraumatischen", "Cholecystitis", "zu", "ueberpruefen", ".", "Prospektiv", "wurde", "ueber", "12", "Monate", "bei", "40", "beatmungspflichtigen", "Patienten", "an", "jeweils", "7", "Tagen", "eine", "Ultraschalluntersuchung", "des", "Oberbauchs", "durchgefuehrt", ".", "Die", "Ergebnisse", "zeigen", ",", "dass", "Beatmung", "parenterale", "Ernaehrung", "und", "die", "Auswirkungen", ",", "einer", "zuvor", "stattgehabten", "Traumatisierung", "des", "Patienten", "zu", "einer", "verzoegerten", "Verdickung", "(", "28/40", ")", "bzw", ".", "Dreischichtung", "(", "9/40", ")", "der", "Gallenblasenwand", "fuehren", "kann", ".", "Sonographisch", "waren", "in", "22,5", "%", "(", "9/40", ")", "die", "Zeichen", "einer", "akuten", "Cholecystitis", "nachweisbar", ".", "In", "Korrelation", "mit", "den", "klinischen", "Parametern", "ergab", "sich", "jedoch", "nur", "in", "2", "Faellen", "die", "Indikation", "zur", "Cholecystektomie", ".", "Unsere", "Studie", "zeigt", ",", "dass", "das", "morphologische", "Korrelat", "einer", "verdickten", "dreischichtigen", "Gallenblasenwand", "auch", "ohne", "zugrundeliegende", "Cholecystitis", "im", "Rahmen", "systemischer", "Veraenderungen", "auftreten", "kann", ".", "Eine", "sichere", "Diagnose", "einer", "akuten", "reaktiven", "Cholecystitis", "mit", "der", "Indikation", "zur", "Cholecystektomie", "konnte", "bei", "pathologischem", "Sonographiebefund", "nur", "in", "enger", "Korrelation", "mit", "klinischen", "Parametern", "gestellt", "werden", "." ]	[ "umlsterm" ]
Komplikation, Patienten, Spezifitaet, Ultraschalldiagnostik, Ultraschallkriterien, Patienten, Ultraschalluntersuchung, parenterale Ernaehrung, Patienten, Gallenblasenwand, Gallenblasenwand, Diagnose, Sonographiebefund	DerChirurg.70680898.ger.abstr_task2	Sentence: Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden .	[ "Zusammenfassung", ".", "Eine", "oft", "unbemerkte", "jedoch", "potentiell", "fatale", "Komplikation", ",", "im", "posttraumatischen", "Verlauf", "intensivpflichtiger", "Patienten", "ist", "die", "reaktive", "akute", "Cholecystitis", ".", "Aufgrund", "der", "hohen", "Spezifitaet", "der", "Ultraschalldiagnostik", "im", "biliaeren", "System", "war", "es", "unser", "Ziel", ",", "die", "Ultraschallkriterien", "zur", "fruehzeitigen", "Objektivierung", "der", "posttraumatischen", "Cholecystitis", "zu", "ueberpruefen", ".", "Prospektiv", "wurde", "ueber", "12", "Monate", "bei", "40", "beatmungspflichtigen", "Patienten", "an", "jeweils", "7", "Tagen", "eine", "Ultraschalluntersuchung", "des", "Oberbauchs", "durchgefuehrt", ".", "Die", "Ergebnisse", "zeigen", ",", "dass", "Beatmung", "parenterale", "Ernaehrung", "und", "die", "Auswirkungen", ",", "einer", "zuvor", "stattgehabten", "Traumatisierung", "des", "Patienten", "zu", "einer", "verzoegerten", "Verdickung", "(", "28/40", ")", "bzw", ".", "Dreischichtung", "(", "9/40", ")", "der", "Gallenblasenwand", "fuehren", "kann", ".", "Sonographisch", "waren", "in", "22,5", "%", "(", "9/40", ")", "die", "Zeichen", "einer", "akuten", "Cholecystitis", "nachweisbar", ".", "In", "Korrelation", "mit", "den", "klinischen", "Parametern", "ergab", "sich", "jedoch", "nur", "in", "2", "Faellen", "die", "Indikation", "zur", "Cholecystektomie", ".", "Unsere", "Studie", "zeigt", ",", "dass", "das", "morphologische", "Korrelat", "einer", "verdickten", "dreischichtigen", "Gallenblasenwand", "auch", "ohne", "zugrundeliegende", "Cholecystitis", "im", "Rahmen", "systemischer", "Veraenderungen", "auftreten", "kann", ".", "Eine", "sichere", "Diagnose", "einer", "akuten", "reaktiven", "Cholecystitis", "mit", "der", "Indikation", "zur", "Cholecystektomie", "konnte", "bei", "pathologischem", "Sonographiebefund", "nur", "in", "enger", "Korrelation", "mit", "klinischen", "Parametern", "gestellt", "werden", "." ]	[ "umlsterm" ]
Thromboseprophylaxe is an umlsterm, Rechtsprechung is an umlsterm, Patient is an umlsterm, Verletzung is an umlsterm, Thromboseprophylaxe is an umlsterm, Gesellschaft is an umlsterm, Thromboseprophylaxe is an umlsterm, Internet is an umlsterm, Arzt is an umlsterm, Fachgesellschaften is an umlsterm, Strafrecht is an umlsterm, Rechtssystematik is an umlsterm, Lungenembolie is an umlsterm	DerUnfallchirurg.71000754.ger.abstr_task0	Sentence: Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen .	[ "Zur", "Frage", ",", "bei", "wem", ",", "wie", "und", "wie", "lange", "Thromboseprophylaxe", "in", "der", "Unfallchirurgie", "durchzufuehren", "ist", ",", "hat", "die", "Rechtsprechung", "bisher", "keine", "konkreten", "Vorschriften", "entwickelt", ".", "Allerdings", "hat", "der", "BGH", "1995", "entschieden", ",", "dass", "der", "Patient", "sowohl", "ueber", "moegliche", "Behandlungsalternativen", "einer", "Verletzung", "aufgeklaert", "werden", "muesse", ",", "wie", "auch", "ueber", "die", "dann", "jeweils", "moegliche", "Form", "der", "Thromboseprophylaxe", ".", "Dies", ",", "in", "Verbindung", "mit", "der", "Tatsache", ",", "dass", "Leitlinien", "der", "Deutschen", "Gesellschaft", "fuer", "Phlebologie", "zur", "Thromboseprophylaxe", "im", "Internet", "verbreitet", "werden", ",", "kann", "im", "Zivilprozess", ",", "wo", "es", "um", "Schadensersatz", "und", "Schmerzensgeld", "geht", ",", "erhebliche", "Auswirkungen", "haben", ".", "Da", "der", "Arzt", "im", "Zivilprozess", "die", "ordnungsgemaess", "erfolgte", "Aufklaerung", "beweisen", "muss", "und", "die", "Leitlinien", "als", "state", "of", "the", "art", "\"", "\"", "missverstanden", "werden", "koennten", ",", "wird", "eine", "Liste", "der", "zu", "beachtenden", "Aufklaerungspunkte", "vorgestellt", "und", "auf", "die", "Problematik", "der", "Leitlinien", "der", "Medizinischen", "Fachgesellschaften", "hingewiesen", ".", "Im", "Strafrecht", "ist", "dagegen", "nach", "der", "deutschen", "Rechtssystematik", "auch", "bei", "toedlicher", "Lungenembolie", "nach", "unterlassener", "oder", "fehlerhafter", "Prophylaxe", "eine", "Verurteilung", "praktisch", "fast", "so", "gut", "wie", "ausgeschlossen", "." ]	[ "umlsterm" ]
Thromboseprophylaxe is an umlsterm, Rechtsprechung is an umlsterm, Patient is an umlsterm, Verletzung is an umlsterm, Thromboseprophylaxe is an umlsterm, Gesellschaft is an umlsterm, Thromboseprophylaxe is an umlsterm, Internet is an umlsterm, Arzt is an umlsterm, Fachgesellschaften is an umlsterm, Strafrecht is an umlsterm, Rechtssystematik is an umlsterm, Lungenembolie is an umlsterm	DerUnfallchirurg.71000754.ger.abstr_task1	Sentence: Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen . Instructions: please typing these entity words according to sentence: Thromboseprophylaxe, Rechtsprechung, Patient, Verletzung, Thromboseprophylaxe, Gesellschaft, Thromboseprophylaxe, Internet, Arzt, Fachgesellschaften, Strafrecht, Rechtssystematik, Lungenembolie Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen .	[ "Zur", "Frage", ",", "bei", "wem", ",", "wie", "und", "wie", "lange", "Thromboseprophylaxe", "in", "der", "Unfallchirurgie", "durchzufuehren", "ist", ",", "hat", "die", "Rechtsprechung", "bisher", "keine", "konkreten", "Vorschriften", "entwickelt", ".", "Allerdings", "hat", "der", "BGH", "1995", "entschieden", ",", "dass", "der", "Patient", "sowohl", "ueber", "moegliche", "Behandlungsalternativen", "einer", "Verletzung", "aufgeklaert", "werden", "muesse", ",", "wie", "auch", "ueber", "die", "dann", "jeweils", "moegliche", "Form", "der", "Thromboseprophylaxe", ".", "Dies", ",", "in", "Verbindung", "mit", "der", "Tatsache", ",", "dass", "Leitlinien", "der", "Deutschen", "Gesellschaft", "fuer", "Phlebologie", "zur", "Thromboseprophylaxe", "im", "Internet", "verbreitet", "werden", ",", "kann", "im", "Zivilprozess", ",", "wo", "es", "um", "Schadensersatz", "und", "Schmerzensgeld", "geht", ",", "erhebliche", "Auswirkungen", "haben", ".", "Da", "der", "Arzt", "im", "Zivilprozess", "die", "ordnungsgemaess", "erfolgte", "Aufklaerung", "beweisen", "muss", "und", "die", "Leitlinien", "als", "state", "of", "the", "art", "\"", "\"", "missverstanden", "werden", "koennten", ",", "wird", "eine", "Liste", "der", "zu", "beachtenden", "Aufklaerungspunkte", "vorgestellt", "und", "auf", "die", "Problematik", "der", "Leitlinien", "der", "Medizinischen", "Fachgesellschaften", "hingewiesen", ".", "Im", "Strafrecht", "ist", "dagegen", "nach", "der", "deutschen", "Rechtssystematik", "auch", "bei", "toedlicher", "Lungenembolie", "nach", "unterlassener", "oder", "fehlerhafter", "Prophylaxe", "eine", "Verurteilung", "praktisch", "fast", "so", "gut", "wie", "ausgeschlossen", "." ]	[ "umlsterm" ]
Thromboseprophylaxe, Rechtsprechung, Patient, Verletzung, Thromboseprophylaxe, Gesellschaft, Thromboseprophylaxe, Internet, Arzt, Fachgesellschaften, Strafrecht, Rechtssystematik, Lungenembolie	DerUnfallchirurg.71000754.ger.abstr_task2	Sentence: Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen .	[ "Zur", "Frage", ",", "bei", "wem", ",", "wie", "und", "wie", "lange", "Thromboseprophylaxe", "in", "der", "Unfallchirurgie", "durchzufuehren", "ist", ",", "hat", "die", "Rechtsprechung", "bisher", "keine", "konkreten", "Vorschriften", "entwickelt", ".", "Allerdings", "hat", "der", "BGH", "1995", "entschieden", ",", "dass", "der", "Patient", "sowohl", "ueber", "moegliche", "Behandlungsalternativen", "einer", "Verletzung", "aufgeklaert", "werden", "muesse", ",", "wie", "auch", "ueber", "die", "dann", "jeweils", "moegliche", "Form", "der", "Thromboseprophylaxe", ".", "Dies", ",", "in", "Verbindung", "mit", "der", "Tatsache", ",", "dass", "Leitlinien", "der", "Deutschen", "Gesellschaft", "fuer", "Phlebologie", "zur", "Thromboseprophylaxe", "im", "Internet", "verbreitet", "werden", ",", "kann", "im", "Zivilprozess", ",", "wo", "es", "um", "Schadensersatz", "und", "Schmerzensgeld", "geht", ",", "erhebliche", "Auswirkungen", "haben", ".", "Da", "der", "Arzt", "im", "Zivilprozess", "die", "ordnungsgemaess", "erfolgte", "Aufklaerung", "beweisen", "muss", "und", "die", "Leitlinien", "als", "state", "of", "the", "art", "\"", "\"", "missverstanden", "werden", "koennten", ",", "wird", "eine", "Liste", "der", "zu", "beachtenden", "Aufklaerungspunkte", "vorgestellt", "und", "auf", "die", "Problematik", "der", "Leitlinien", "der", "Medizinischen", "Fachgesellschaften", "hingewiesen", ".", "Im", "Strafrecht", "ist", "dagegen", "nach", "der", "deutschen", "Rechtssystematik", "auch", "bei", "toedlicher", "Lungenembolie", "nach", "unterlassener", "oder", "fehlerhafter", "Prophylaxe", "eine", "Verurteilung", "praktisch", "fast", "so", "gut", "wie", "ausgeschlossen", "." ]	[ "umlsterm" ]
Aranesp is a BRAND	Darbepoetin alfa_ddi_task0	Sentence: No formal drug interaction studies of Aranesp have been performed. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: BRAND	[ "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O" ]	No formal drug interaction studies of Aranesp have been performed.	[ "No", "formal", "drug", "interaction", "studies", "of", "Aranesp", " ", "have", "been", "performed", "." ]	[ "BRAND" ]
Aranesp is a BRAND	Darbepoetin alfa_ddi_task1	Sentence: No formal drug interaction studies of Aranesp have been performed. Instructions: please typing these entity words according to sentence: Aranesp Options: BRAND	[ "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O" ]	No formal drug interaction studies of Aranesp have been performed.	[ "No", "formal", "drug", "interaction", "studies", "of", "Aranesp", " ", "have", "been", "performed", "." ]	[ "BRAND" ]
Aranesp	Darbepoetin alfa_ddi_task2	Sentence: No formal drug interaction studies of Aranesp have been performed. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O" ]	No formal drug interaction studies of Aranesp have been performed.	[ "No", "formal", "drug", "interaction", "studies", "of", "Aranesp", " ", "have", "been", "performed", "." ]	[ "BRAND" ]
Abstract is an umlsterm, cytokine is an umlsterm, light is an umlsterm, leukocyte is an umlsterm, release is an umlsterm, concentration is an umlsterm, IL-12 is an umlsterm, polytrauma is an umlsterm, Methods is an umlsterm, concentrations is an umlsterm, IL-12 is an umlsterm, polytrauma is an umlsterm, patients is an umlsterm, donor is an umlsterm, values is an umlsterm, intensive care is an umlsterm, ELISA is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, normal range is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, survivors is an umlsterm, Patients is an umlsterm, single is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, IL-12 is an umlsterm, values is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, patients is an umlsterm, intensive care unit is an umlsterm, MODS is an umlsterm, CRP is an umlsterm, values is an umlsterm, leukocyte counts is an umlsterm, Correlation analysis is an umlsterm, IL-12 is an umlsterm, values is an umlsterm, MODS is an umlsterm, injuries is an umlsterm, overall is an umlsterm, IL-12 is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, survivors is an umlsterm, patients is an umlsterm, IL-12 is an umlsterm, risk of is an umlsterm, multi - organ failure is an umlsterm	DerChirurg.00711126.eng.abstr_task0	Sentence: Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure .	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Abstract is an umlsterm, cytokine is an umlsterm, light is an umlsterm, leukocyte is an umlsterm, release is an umlsterm, concentration is an umlsterm, IL-12 is an umlsterm, polytrauma is an umlsterm, Methods is an umlsterm, concentrations is an umlsterm, IL-12 is an umlsterm, polytrauma is an umlsterm, patients is an umlsterm, donor is an umlsterm, values is an umlsterm, intensive care is an umlsterm, ELISA is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, normal range is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, survivors is an umlsterm, Patients is an umlsterm, single is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, IL-12 is an umlsterm, values is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, patients is an umlsterm, intensive care unit is an umlsterm, MODS is an umlsterm, CRP is an umlsterm, values is an umlsterm, leukocyte counts is an umlsterm, Correlation analysis is an umlsterm, IL-12 is an umlsterm, values is an umlsterm, MODS is an umlsterm, injuries is an umlsterm, overall is an umlsterm, IL-12 is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, survivors is an umlsterm, patients is an umlsterm, IL-12 is an umlsterm, risk of is an umlsterm, multi - organ failure is an umlsterm	DerChirurg.00711126.eng.abstr_task1	Sentence: Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure . Instructions: please typing these entity words according to sentence: Abstract, cytokine, light, leukocyte, release, concentration, IL-12, polytrauma, Methods, concentrations, IL-12, polytrauma, patients, donor, values, intensive care, ELISA, Patients, IL-12, IL-12, IL-12, IL-12, normal range, Patients, IL-12, thorax, trauma, pneumonia, survivors, Patients, single, thorax, trauma, pneumonia, thorax, trauma, IL-12, values, Patients, IL-12, thorax, trauma, pneumonia, patients, intensive care unit, MODS, CRP, values, leukocyte counts, Correlation analysis, IL-12, values, MODS, injuries, overall, IL-12, Patients, IL-12, survivors, patients, IL-12, risk of, multi - organ failure Options: umlsterm	[ "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O" ]	Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure .	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Abstract, cytokine, light, leukocyte, release, concentration, IL-12, polytrauma, Methods, concentrations, IL-12, polytrauma, patients, donor, values, intensive care, ELISA, Patients, IL-12, IL-12, IL-12, IL-12, normal range, Patients, IL-12, thorax, trauma, pneumonia, survivors, Patients, single, thorax, trauma, pneumonia, thorax, trauma, IL-12, values, Patients, IL-12, thorax, trauma, pneumonia, patients, intensive care unit, MODS, CRP, values, leukocyte counts, Correlation analysis, IL-12, values, MODS, injuries, overall, IL-12, Patients, IL-12, survivors, patients, IL-12, risk of, multi - organ failure	DerChirurg.00711126.eng.abstr_task2	Sentence: Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure . 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Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure .	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monocular augmented reality technology is a Intervention_Other, Augmented reality ( AR ) technologies is a Intervention_Educational, AR technology is a Intervention_Other, 45 is a Participant_Sample-size, visual impairment is a Participant_Condition, conventional working aids ( paper - based documents ) to support the task processing is a Intervention_Educational, HMD unit that was switched off . is a Intervention_Other, HMD without any additional aids . is a Intervention_Educational, mental strain is a Outcome_Mental, concentration - test performance is a Outcome_Mental, physical or mental complaints is a Outcome_Physical, higher pressure is a Outcome_Physical, blurred vision in both eyes is a Outcome_Physical, headaches is a Outcome_Physical, ergonomic hardware design is a Outcome_Physical	31922_task0	Sentence: [ Potentials of monocular augmented reality technology in automobile production ] . INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed . 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INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed .	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monocular augmented reality technology is a Intervention_Other, Augmented reality ( AR ) technologies is a Intervention_Educational, AR technology is a Intervention_Other, 45 is a Participant_Sample-size, visual impairment is a Participant_Condition, conventional working aids ( paper - based documents ) to support the task processing is a Intervention_Educational, HMD unit that was switched off . is a Intervention_Other, HMD without any additional aids . is a Intervention_Educational, mental strain is a Outcome_Mental, concentration - test performance is a Outcome_Mental, physical or mental complaints is a Outcome_Physical, higher pressure is a Outcome_Physical, blurred vision in both eyes is a Outcome_Physical, headaches is a Outcome_Physical, ergonomic hardware design is a Outcome_Physical	31922_task1	Sentence: [ Potentials of monocular augmented reality technology in automobile production ] . INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed . Instructions: please typing these entity words according to sentence: monocular augmented reality technology, Augmented reality ( AR ) technologies, AR technology, 45, visual impairment, conventional working aids ( paper - based documents ) to support the task processing, HMD unit that was switched off ., HMD without any additional aids ., mental strain, concentration - test performance, physical or mental complaints, higher pressure, blurred vision in both eyes, headaches, ergonomic hardware design Options: Participant_Condition, Intervention_Educational, Intervention_Other, Outcome_Physical, Participant_Sample-size, Outcome_Mental	[ "O", "O", "O", "B-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "I-Intervention_Other", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "B-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "I-Intervention_Other", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "B-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	[ Potentials of monocular augmented reality technology in automobile production ] . INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed .	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monocular augmented reality technology, Augmented reality ( AR ) technologies, AR technology, 45, visual impairment, conventional working aids ( paper - based documents ) to support the task processing, HMD unit that was switched off ., HMD without any additional aids ., mental strain, concentration - test performance, physical or mental complaints, higher pressure, blurred vision in both eyes, headaches, ergonomic hardware design	31922_task2	Sentence: [ Potentials of monocular augmented reality technology in automobile production ] . INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed . 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INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed .	[ "[", "Potentials", "of", "monocular", "augmented", "reality", "technology", "in", "automobile", "production", "]", ".", "INTRODUCTION", "Augmented", "reality", "(", "AR", ")", "technologies", "can", "enrich", "the", "real", "environment", "with", "visual", "data", ",", "which", "has", "potential", "benefits", "for", "optimising", "the", "operator", "'", "s", "working", "process", ".", "It", "offers", "the", "possibility", "to", "provide", "context", "-", "sensitive", "information", "independently", "of", "the", "user", "'", "s", "location", "and", "position", ".", "Data", "are", "presented", "to", "the", "dominant", "eye", "on", "a", "semi", "-", "transparent", "mirror", "using", "a", "head", "-", "mounted", "display", "(", "HMD", ")", "unit", "that", "works", "with", "retinal", "laser", "technology", ".", "In", "this", "study", "the", "potential", "benefits", "and", "drawbacks", "of", "this", "new", "AR", "technology", "were", "evaluated", ".", "MATERIALS", "AND", "METHODS", "45", "participants", "without", "any", "visual", "impairment", "were", "randomly", "assigned", "to", "3", "groups", "and", "completed", "a", "variety", "of", "tasks", "during", "a", "simulated", "working", "day", ".", "Group", "1", "received", "conventional", "working", "aids", "(", "paper", "-", "based", "documents", ")", "to", "support", "the", "task", "processing", ".", "Group", "2", "additionally", "wore", "an", "HMD", "unit", "that", "was", "switched", "off", ".", "Group", "3", "wore", "a", "functioning", "HMD", "without", "any", "additional", "aids", ".", "Evaluation", "was", "carried", "out", "by", "means", "of", "a", "standardised", "questionnaire", "(", "BMS", ")", "and", "a", "concentration", "test", "(", "\"", "d2", "Aufmerksamkeits", "-", "Belastungs", "-", "Test", "\"", ")", ".", "RESULTS", "No", "significant", "differences", "between", "the", "3", "groups", "were", "found", "in", "terms", "of", "mental", "strain", ",", "concentration", "-", "test", "performance", "and", "physical", "or", "mental", "complaints", "reported", "in", "a", "follow", "-", "up", "interview", ".", "Around", "20", "%", "of", "the", "subjects", "noticed", "a", "higher", "pressure", "and", "blurred", "vision", "in", "both", "eyes", "as", "well", "as", "headaches", ".", "Half", "of", "the", "participants", "complained", "about", "deficiencies", "concerning", "the", "ergonomic", "hardware", "design", "of", "the", "AR", "system", ".", "DISCUSSION", "Changes", "in", "objective", "ophthalmological", "investigation", "parameters", "were", "not", "observed", ".", "Subjects", "reported", "reduced", "acceptance", "of", "the", "HMD", "based", "on", "non", "-", "ophthalmological", "reasons", ",", "for", "example", ",", "the", "weight", "of", "the", "unit", "or", "the", "length", "of", "the", "cable", ".", "However", ",", "for", "some", "specific", "working", "tasks", ",", "advantages", "in", "process", "optimisation", "and", "operator", "support", "were", "observed", "." ]	[ "Intervention_Educational", "Intervention_Other", "Outcome_Mental", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]
IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, TNF - alpha is a Protein, TNF - alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein	389_task0	Sentence: Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation. 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The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation.	[ "Regulation", "of", "IkB", "alpha", "phosphorylation", "by", "PKC-", "and", "Ca(2+)-dependent", "signal", "transduction", "pathways", ".", "\n", "The", "Ca(2+)-dependent", "phosphatase", "calcineurin", ",", "a", "target", "of", "FK506", "and", "CsA", ",", "synergizes", "with", "PKC", "-", "induced", "activation", "of", "nuclear", "factor", "(", "NF)-kappa", "B", "in", "T", "cell", "lines", ".", "We", "have", "investigated", "whether", "this", "synergy", "is", "present", "in", "other", "cell", "types", "and", "the", "mechanism(s", ")", "by", "which", "these", "two", "pathways", "lead", "to", "NF", "-", "kappa", "B", "activation", ".", "While", "this", "synergy", "is", "present", "in", "other", "cell", "types", ",", "in", "the", "monocytic", "cell", "line", "U937", "calcineurin", "is", "also", "sufficient", "to", "activate", "NF", "-", "kappa", "B.", "Having", "previously", "shown", "that", "Ca(2+)-", "and", "PKC", "-", "dependent", "pathways", "synergize", "by", "accelerating", "the", "degradation", "of", "IkB", "alpha", ",", "we", "focused", "on", "the", "regulation", "of", "IkB", "alpha", "phosphorylation", ".", "While", "PKC", "-", "dependent", "pathways", "sequentially", "result", "in", "the", "phosphorylation", "and", "in", "an", "incomplete", "degradation", "of", "IkB", "alpha", "in", "T", "cell", "lines", ",", "co", "-", "activation", "of", "Ca(2+)-dependent", "pathways", "accelerates", "the", "rate", "of", "IkB", "alpha", "phosphorylation", "and", "results", "in", "its", "complete", "degradation", ".", "Activation", "of", "Ca(2+)-dependent", "pathways", "alone", "do", "not", "result", "in", "the", "phosphorylation", "and", "/", "or", "degradation", "of", "IkB", "alpha", "in", "Jurkat", "T", "or", "in", "U937", "cells", ".", "Treatment", "of", "T", "cells", "with", "the", "selective", "PKC", "inhibitor", "GF109203X", "abrogates", "the", "PMA", "-", "induced", "IkB", "alpha", "phosphorylation", "/", "degradation", "irrespective", "of", "activation", "of", "Ca(2+)-dependent", "pathways", ",", "but", "not", "the", "phosphorylation", "and", "degradation", "of", "IkB", "alpha", "induced", "by", "TNF", "-", "alpha", ",", "a", "PKC", "-", "independent", "stimulus", ".", "Contrary", "to", "the", "interaction", "with", "PKC", ",", "Ca(2+)-dependent", "pathways", "synergize", "with", "TNF", "-", "alpha", "not", "at", "the", "level", "of", "IkB", "alpha", "phosphorylation", ",", "but", "at", "the", "level", "of", "its", "degradation", ".", "These", "results", "indicate", "that", "Ca(2+)-dependent", "pathways", ",", "including", "the", "phosphatase", "calcineurin", ",", "participate", "in", "the", "regulation", "of", "NF", "-", "kappa", "B", "in", "a", "cell", "specific", "fashion", "and", "synergize", "with", "PKC", "-", "dependent", "and", "-independent", "pathways", "at", "the", "level", "of", "IkB", "alpha", "phosphorylation", "and", "degradation", "." ]	[ "Protein" ]
IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, TNF - alpha is a Protein, TNF - alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein	389_task1	Sentence: Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation. 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The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation.	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IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, TNF - alpha, TNF - alpha, IkB alpha, IkB alpha	389_task2	Sentence: Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O" ]	Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation.	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Akathisie is an umlsterm, Patienten is an umlsterm, Verwendung is an umlsterm, stressevozierenden is an umlsterm, Akathisie is an umlsterm, Stressinduktion is an umlsterm, Akathisie is an umlsterm, Bewegungsstoerungen is an umlsterm	DerNervenarzt.00710030.ger.abstr_task0	Sentence: In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein .	[ "In", "dieser", "Studie", "wurden", "die", "Wirkungen", "verschiedener", "Aktivierungstests", "auf", "die", "motorische", "und", "psychische", "Symptomatik", "der", "akuten", "neuroleptikainduzierten", "Akathisie", "an", "11", "Patienten", "unter", "Verwendung", "der", "Hillside-", "und", "Barnes", "-", "Akathisie", "-", "Skalen", "sowie", "der", "Videotape", "Rating", "Technique", "experimentell", "untersucht", ".", "Zur", "motorischen", "Aktivierung", "wurde", "Finger", "-", "Tapping", "eingesetzt", ".", "Die", "kognitive", "Aktivierung", "bestand", "in", "sequenziellem", "Kopfrechnen", ",", "wobei", "unterschieden", "wurde", "zwischen", "einerseits", "nur", "geringfuegig", "und", "andererseits", "staerker", "stressevozierenden", "Aufgaben", ",", "und", "zwar", "durch", "den", "Einsatz", "von", "Zeitdruck", "bzw", ".", "einen", "hohen", "Schwierigkeitsgrad", "der", "betreffenden", "Rechenoperationen", ".", "Motorische", "und", "gering", "belastende", "kognitive", "Aktivierung", "reduzierte", "sowohl", "motorische", "als", "auch", "psychische", "Symptome", "der", "Akathisie", "statistisch", "signifikant", ".", "Dagegen", "fuehrte", "zusaetzliche", "Stressinduktion", "im", "Rahmen", "der", "kognitiven", "Aktivierung", "zu", "einer", "Aufhebung", "dieses", "Effekts", "sowie", "zu", "einer", "Zunahme", "motorischer", "wie", "auch", "psychischer", "Symptome", "unmittelbar", "nach", "Beendigung", "der", "Aktivierungsaufgabe", ".", "Diese", "moeglicherweise", "spezifischen", "Wirkungen", "von", "Aktivierungstests", "auf", "die", "Symptomatik", "koennten", "bei", "der", "differenzialdiagnostischen", "Abgrenzung", "der", "akuten", "neuroleptikainduzierten", "Akathisie", "von", "anderen", "neuroleptikainduzierten", "und", "extrapyramidalen", "Bewegungsstoerungen", "nuetzlich", "sein", "." ]	[ "umlsterm" ]
Akathisie is an umlsterm, Patienten is an umlsterm, Verwendung is an umlsterm, stressevozierenden is an umlsterm, Akathisie is an umlsterm, Stressinduktion is an umlsterm, Akathisie is an umlsterm, Bewegungsstoerungen is an umlsterm	DerNervenarzt.00710030.ger.abstr_task1	Sentence: In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein . Instructions: please typing these entity words according to sentence: Akathisie, Patienten, Verwendung, stressevozierenden, Akathisie, Stressinduktion, Akathisie, Bewegungsstoerungen Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein .	[ "In", "dieser", "Studie", "wurden", "die", "Wirkungen", "verschiedener", "Aktivierungstests", "auf", "die", "motorische", "und", "psychische", "Symptomatik", "der", "akuten", "neuroleptikainduzierten", "Akathisie", "an", "11", "Patienten", "unter", "Verwendung", "der", "Hillside-", "und", "Barnes", "-", "Akathisie", "-", "Skalen", "sowie", "der", "Videotape", "Rating", "Technique", "experimentell", "untersucht", ".", "Zur", "motorischen", "Aktivierung", "wurde", "Finger", "-", "Tapping", "eingesetzt", ".", "Die", "kognitive", "Aktivierung", "bestand", "in", "sequenziellem", "Kopfrechnen", ",", "wobei", "unterschieden", "wurde", "zwischen", "einerseits", "nur", "geringfuegig", "und", "andererseits", "staerker", "stressevozierenden", "Aufgaben", ",", "und", "zwar", "durch", "den", "Einsatz", "von", "Zeitdruck", "bzw", ".", "einen", "hohen", "Schwierigkeitsgrad", "der", "betreffenden", "Rechenoperationen", ".", "Motorische", "und", "gering", "belastende", "kognitive", "Aktivierung", "reduzierte", "sowohl", "motorische", "als", "auch", "psychische", "Symptome", "der", "Akathisie", "statistisch", "signifikant", ".", "Dagegen", "fuehrte", "zusaetzliche", "Stressinduktion", "im", "Rahmen", "der", "kognitiven", "Aktivierung", "zu", "einer", "Aufhebung", "dieses", "Effekts", "sowie", "zu", "einer", "Zunahme", "motorischer", "wie", "auch", "psychischer", "Symptome", "unmittelbar", "nach", "Beendigung", "der", "Aktivierungsaufgabe", ".", "Diese", "moeglicherweise", "spezifischen", "Wirkungen", "von", "Aktivierungstests", "auf", "die", "Symptomatik", "koennten", "bei", "der", "differenzialdiagnostischen", "Abgrenzung", "der", "akuten", "neuroleptikainduzierten", "Akathisie", "von", "anderen", "neuroleptikainduzierten", "und", "extrapyramidalen", "Bewegungsstoerungen", "nuetzlich", "sein", "." ]	[ "umlsterm" ]
Akathisie, Patienten, Verwendung, stressevozierenden, Akathisie, Stressinduktion, Akathisie, Bewegungsstoerungen	DerNervenarzt.00710030.ger.abstr_task2	Sentence: In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O" ]	In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein .	[ "In", "dieser", "Studie", "wurden", "die", "Wirkungen", "verschiedener", "Aktivierungstests", "auf", "die", "motorische", "und", "psychische", "Symptomatik", "der", "akuten", "neuroleptikainduzierten", "Akathisie", "an", "11", "Patienten", "unter", "Verwendung", "der", "Hillside-", "und", "Barnes", "-", "Akathisie", "-", "Skalen", "sowie", "der", "Videotape", "Rating", "Technique", "experimentell", "untersucht", ".", "Zur", "motorischen", "Aktivierung", "wurde", "Finger", "-", "Tapping", "eingesetzt", ".", "Die", "kognitive", "Aktivierung", "bestand", "in", "sequenziellem", "Kopfrechnen", ",", "wobei", "unterschieden", "wurde", "zwischen", "einerseits", "nur", "geringfuegig", "und", "andererseits", "staerker", "stressevozierenden", "Aufgaben", ",", "und", "zwar", "durch", "den", "Einsatz", "von", "Zeitdruck", "bzw", ".", "einen", "hohen", "Schwierigkeitsgrad", "der", "betreffenden", "Rechenoperationen", ".", "Motorische", "und", "gering", "belastende", "kognitive", "Aktivierung", "reduzierte", "sowohl", "motorische", "als", "auch", "psychische", "Symptome", "der", "Akathisie", "statistisch", "signifikant", ".", "Dagegen", "fuehrte", "zusaetzliche", "Stressinduktion", "im", "Rahmen", "der", "kognitiven", "Aktivierung", "zu", "einer", "Aufhebung", "dieses", "Effekts", "sowie", "zu", "einer", "Zunahme", "motorischer", "wie", "auch", "psychischer", "Symptome", "unmittelbar", "nach", "Beendigung", "der", "Aktivierungsaufgabe", ".", "Diese", "moeglicherweise", "spezifischen", "Wirkungen", "von", "Aktivierungstests", "auf", "die", "Symptomatik", "koennten", "bei", "der", "differenzialdiagnostischen", "Abgrenzung", "der", "akuten", "neuroleptikainduzierten", "Akathisie", "von", "anderen", "neuroleptikainduzierten", "und", "extrapyramidalen", "Bewegungsstoerungen", "nuetzlich", "sein", "." ]	[ "umlsterm" ]
Pregnancy is a Condition, hypersensitivity is a Condition, study drug is a Drug, ferric carboxymaltose is a Drug, Known or suspected is a Scope, haemoglobinopathy / thalassaemia is a Scope, Bone marrow disease is a Condition, Haemochromatosis is a Condition, Renal dialysis is a Procedure, Erythropoietin or IV iron is a Scope, in the previous 4 weeks is a Temporal	NCT02632760_exc_task0	Sentence: Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Procedure, Scope, Drug	[ "B-Condition", "O", "O", "B-Condition", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]	Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks	[ "Pregnancy", "\n", "Known", "hypersensitivity", "to", "study", "drug", "(", "ferric", "carboxymaltose", "or", "equivalent", ")", "or", "its", "excipients", "\n", "Known", "or", "suspected", "haemoglobinopathy", "/", "thalassaemia", "\n", "Bone", "marrow", "disease", "\n", "Haemochromatosis", "\n", "Renal", "dialysis", "\n", "Erythropoietin", "or", "IV", "iron", "in", "the", "previous", "4", "weeks", "\n" ]	[ "Scope", "Temporal", "Drug", "Condition", "Procedure", "Mood" ]
Pregnancy is a Condition, hypersensitivity is a Condition, study drug is a Drug, ferric carboxymaltose is a Drug, Known or suspected is a Scope, haemoglobinopathy / thalassaemia is a Scope, Bone marrow disease is a Condition, Haemochromatosis is a Condition, Renal dialysis is a Procedure, Erythropoietin or IV iron is a Scope, in the previous 4 weeks is a Temporal	NCT02632760_exc_task1	Sentence: Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks Instructions: please typing these entity words according to sentence: Pregnancy, hypersensitivity, study drug, ferric carboxymaltose, Known or suspected, haemoglobinopathy / thalassaemia, Bone marrow disease, Haemochromatosis, Renal dialysis, Erythropoietin or IV iron, in the previous 4 weeks Options: Temporal, Condition, Procedure, Scope, Drug	[ "B-Condition", "O", "O", "B-Condition", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]	Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks	[ "Pregnancy", "\n", "Known", "hypersensitivity", "to", "study", "drug", "(", "ferric", "carboxymaltose", "or", "equivalent", ")", "or", "its", "excipients", "\n", "Known", "or", "suspected", "haemoglobinopathy", "/", "thalassaemia", "\n", "Bone", "marrow", "disease", "\n", "Haemochromatosis", "\n", "Renal", "dialysis", "\n", "Erythropoietin", "or", "IV", "iron", "in", "the", "previous", "4", "weeks", "\n" ]	[ "Scope", "Temporal", "Drug", "Condition", "Procedure", "Mood" ]
Pregnancy, hypersensitivity, study drug, ferric carboxymaltose, Known or suspected, haemoglobinopathy / thalassaemia, Bone marrow disease, Haemochromatosis, Renal dialysis, Erythropoietin or IV iron, in the previous 4 weeks	NCT02632760_exc_task2	Sentence: Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks Instructions: please extract entity words from the input sentence	[ "B-Condition", "O", "O", "B-Condition", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]	Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks	[ "Pregnancy", "\n", "Known", "hypersensitivity", "to", "study", "drug", "(", "ferric", "carboxymaltose", "or", "equivalent", ")", "or", "its", "excipients", "\n", "Known", "or", "suspected", "haemoglobinopathy", "/", "thalassaemia", "\n", "Bone", "marrow", "disease", "\n", "Haemochromatosis", "\n", "Renal", "dialysis", "\n", "Erythropoietin", "or", "IV", "iron", "in", "the", "previous", "4", "weeks", "\n" ]	[ "Scope", "Temporal", "Drug", "Condition", "Procedure", "Mood" ]
diagnostic laboratory tests is a Procedure, complete blood count is a Procedure, acute phase reactants is a Procedure, erythrocyte sedimentation rate and C - reactive protein is a Scope, acute is a Qualifier, non - specific low back pain is a Condition, history and physical examinations is a Scope, pain is a Condition, area between the 12th rib and buttock crease is a Qualifier, without is a Negation, leg pain is a Condition, Female is a Person, male is a Person, 20 - 80 years is a Value, age is a Person, Low back pain is a Condition, less than six weeks ' duration is a Temporal, at least moderate pain intensity is a Scope, NRS < U+2267>4 is a Scope	NCT03171987_inc_task0	Sentence: All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Person, Procedure, Negation, Scope	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Negation", "B-Condition", "I-Condition", "O", "B-Person", "O", "B-Person", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O" ]	All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4)	[ "All", "subjects", "underwent", "a", "detailed", "history", "and", "systemic", "physical", "examination", "including", "neurologic", "and", "musculoskeletal", "evaluations", ".", "To", "rule", "out", "any", "confounding", "etiologies", ",", "basic", "diagnostic", "laboratory", "tests", "including", "complete", "blood", "count", "and", "acute", "phase", "reactants", "(", "erythrocyte", "sedimentation", "rate", "and", "C", "-", "reactive", "protein", ")", "were", "performed", ".", "The", "patients", "diagnosed", "as", "having", "acute", "non", "-", "specific", "low", "back", "pain", "according", "to", "history", "and", "physical", "examinations", "were", "invited", "to", "participate", "and", "will", "be", "informed", "about", "the", "purpose", "and", "course", "of", "the", "study", ".", "\n", "A", "primary", "complaint", "of", "pain", "in", "the", "area", "between", "the", "12th", "rib", "and", "buttock", "crease", "without", "leg", "pain", "\n", "Female", "or", "male", ",", "20", "-", "80", "years", "of", "age", "\n", "Low", "back", "pain", "of", "less", "than", "six", "weeks", "'", "duration", ";", "and", "at", "least", "moderate", "pain", "intensity", "(", "NRS", "<", "U+2267>4", ")", "\n" ]	[ "Scope", "Qualifier", "Procedure", "Temporal", "Condition", "Value", "Measurement", "Observation", "Negation", "Person" ]
diagnostic laboratory tests is a Procedure, complete blood count is a Procedure, acute phase reactants is a Procedure, erythrocyte sedimentation rate and C - reactive protein is a Scope, acute is a Qualifier, non - specific low back pain is a Condition, history and physical examinations is a Scope, pain is a Condition, area between the 12th rib and buttock crease is a Qualifier, without is a Negation, leg pain is a Condition, Female is a Person, male is a Person, 20 - 80 years is a Value, age is a Person, Low back pain is a Condition, less than six weeks ' duration is a Temporal, at least moderate pain intensity is a Scope, NRS < U+2267>4 is a Scope	NCT03171987_inc_task1	Sentence: All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4) Instructions: please typing these entity words according to sentence: diagnostic laboratory tests, complete blood count, acute phase reactants, erythrocyte sedimentation rate and C - reactive protein, acute, non - specific low back pain, history and physical examinations, pain, area between the 12th rib and buttock crease, without, leg pain, Female, male, 20 - 80 years, age, Low back pain, less than six weeks ' duration, at least moderate pain intensity, NRS < U+2267>4 Options: Temporal, Condition, Qualifier, Value, Person, Procedure, Negation, Scope	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Negation", "B-Condition", "I-Condition", "O", "B-Person", "O", "B-Person", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O" ]	All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4)	[ "All", "subjects", "underwent", "a", "detailed", "history", "and", "systemic", "physical", "examination", "including", "neurologic", "and", "musculoskeletal", "evaluations", ".", "To", "rule", "out", "any", "confounding", "etiologies", ",", "basic", "diagnostic", "laboratory", "tests", "including", "complete", "blood", "count", "and", "acute", "phase", "reactants", "(", "erythrocyte", "sedimentation", "rate", "and", "C", "-", "reactive", "protein", ")", "were", "performed", ".", "The", "patients", "diagnosed", "as", "having", "acute", "non", "-", "specific", "low", "back", "pain", "according", "to", "history", "and", "physical", "examinations", "were", "invited", "to", "participate", "and", "will", "be", "informed", "about", "the", "purpose", "and", "course", "of", "the", "study", ".", "\n", "A", "primary", "complaint", "of", "pain", "in", "the", "area", "between", "the", "12th", "rib", "and", "buttock", "crease", "without", "leg", "pain", "\n", "Female", "or", "male", ",", "20", "-", "80", "years", "of", "age", "\n", "Low", "back", "pain", "of", "less", "than", "six", "weeks", "'", "duration", ";", "and", "at", "least", "moderate", "pain", "intensity", "(", "NRS", "<", "U+2267>4", ")", "\n" ]	[ "Scope", "Qualifier", "Procedure", "Temporal", "Condition", "Value", "Measurement", "Observation", "Negation", "Person" ]
diagnostic laboratory tests, complete blood count, acute phase reactants, erythrocyte sedimentation rate and C - reactive protein, acute, non - specific low back pain, history and physical examinations, pain, area between the 12th rib and buttock crease, without, leg pain, Female, male, 20 - 80 years, age, Low back pain, less than six weeks ' duration, at least moderate pain intensity, NRS < U+2267>4	NCT03171987_inc_task2	Sentence: All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4) Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Procedure", "I-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Condition", "O", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "B-Negation", "B-Condition", "I-Condition", "O", "B-Person", "O", "B-Person", "O", "B-Value", "I-Value", "I-Value", "I-Value", "O", "B-Person", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O" ]	All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4)	[ "All", "subjects", "underwent", "a", "detailed", "history", "and", "systemic", "physical", "examination", "including", "neurologic", "and", "musculoskeletal", "evaluations", ".", "To", "rule", "out", "any", "confounding", "etiologies", ",", "basic", "diagnostic", "laboratory", "tests", "including", "complete", "blood", "count", "and", "acute", "phase", "reactants", "(", "erythrocyte", "sedimentation", "rate", "and", "C", "-", "reactive", "protein", ")", "were", "performed", ".", "The", "patients", "diagnosed", "as", "having", "acute", "non", "-", "specific", "low", "back", "pain", "according", "to", "history", "and", "physical", "examinations", "were", "invited", "to", "participate", "and", "will", "be", "informed", "about", "the", "purpose", "and", "course", "of", "the", "study", ".", "\n", "A", "primary", "complaint", "of", "pain", "in", "the", "area", "between", "the", "12th", "rib", "and", "buttock", "crease", "without", "leg", "pain", "\n", "Female", "or", "male", ",", "20", "-", "80", "years", "of", "age", "\n", "Low", "back", "pain", "of", "less", "than", "six", "weeks", "'", "duration", ";", "and", "at", "least", "moderate", "pain", "intensity", "(", "NRS", "<", "U+2267>4", ")", "\n" ]	[ "Scope", "Qualifier", "Procedure", "Temporal", "Condition", "Value", "Measurement", "Observation", "Negation", "Person" ]
Sehnervenschaeden is an umlsterm, Behandlung is an umlsterm, kopfverletzten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Sehnervenschaeden is an umlsterm, Element is an umlsterm, Sehnervenschaeden is an umlsterm, Bewusstseinsgrad is an umlsterm, Patienten is an umlsterm, Sehnervenschaeden is an umlsterm, Therapie is an umlsterm, Arbeit is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Sehnervenschaeden is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Therapieerfolg is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Sehnervenschaedigung is an umlsterm	MundKieferGesichtschirurgie.8002s107.ger.abstr_task0	Sentence: Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen .	[ "Traumatische", "Sehnervenschaeden", "stellen", "eine", "klinische", "Herausforderung", "dar", ",", "da", "ihre", "Frueherkennung", "und", "Behandlung", "nicht", "systematisiert", "sind", ".", "Neuroophthalmologische", "Tests", "sind", "prinzipiell", "sichere", "Verfahren", "zur", "Feststellung", "eines", "Sehbahnschadens", ",", "jedoch", "koennen", "sie", "lediglich", "in", "ca", ".", "30", "%", "der", "schwer", "kopfverletzten", "Patienten", "erfolgreich", "angewendet", "werden", ";", "besonders", "bei", "polytraumatisierten", "Patienten", "sind", "Sehnervenschaeden", "schwer", "zu", "erheben", ".", "Wir", "haben", "mit", "Hilfe", "der", "bekannten", "Blitz", "-", "VEP", "ERG", "-", "Untersuchung", "ein", "sicheres", "diagnostisches", "Element", "zur", "Frueherkennung", "traumatischer", "Sehnervenschaeden", "unabhaengig", "vom", "Bewusstseinsgrad", "des", "Verletzten", "erarbeitet", ".", "Neben", "dem", "Problem", "der", "Frueherkennung", "besteht", "Unsicherheit", "im", "Hinblick", "auf", "eine", "klare", "therapeutische", "Richtlinie", "fuer", "Patienten", "mit", "traumatischen", "Sehnervenschaeden", "-", "konservative", "vs", ".", "chirurgische", "Therapie", ".", "Ziel", "dieser", "Arbeit", "war", "es", ",", "unabhaengig", "von", "der", "Kooperationsfaehigkeit", "des", "Patienten", "einen", "verlaesslichen", "Plan", "zur", "interdisziplinaeren", "Frueherkennung", "und", "Therapie", "traumatischer", "Sehnervenschaeden", "auf", "der", "Basis", "von", "neuroophthalmologischen", ",", "Spiral", "-", "CT-", "und", "neurophysiologischen", "Befunden", "zu", "erstellen", ",", "so", "dass", "fuer", "jeden", "Patienten", "eine", "klare", "Richtlinie", "fuer", "oder", "gegen", "eine", "Therapie", "vorliegt", ".", "Insgesamt", "wurden", "52", "Patienten", "mit", "Hilfe", "dieses", "diagnostischen", "Stufenplans", "untersucht", ";", "hiervon", "konnten", "bei", "insgesamt", "20", "Patienten", "posttraumatische", "afferente", "Sehbahnschaeden", "diagnostiziert", "werden", ".", "Obwohl", "der", "Beweis", "fuer", "einen", "Therapieerfolg", "nur", "schwer", "zu", "erbringen", "ist", ",", "konnte", "aus", "der", "Gruppe", "der", "kooperativen", "Patienten", "bei", "3", "einseitig", "amaurotischen", "Patienten", "nach", "unmittelbarer", "Einleitung", "der", "kombinierten", "konservativen", "und", "operativen", "Behandlung", "eine", "partielle", "Restitution", "der", "geschaedigten", "Sehbahnfunktion", "erzielt", "werden", ".", "In", "den", "meisten", "Kliniken", "wird", "nach", "wie", "vor", "das", "Problem", "der", "traumatischen", "Sehnervenschaedigung", "nach", "dem", "Wait", "-", "and", "-", "see", "-", "Prinzip", "angegangen", ".", "Wir", "halten", "ein", "solches", "Vorgehen", "fuer", "nicht", "gerechtfertigt", ",", "da", "es", "klare", "Alternativen", "gibt", ",", "die", "im", "folgenden", "vorgestellt", "werden", "sollen", "." ]	[ "umlsterm" ]
Sehnervenschaeden is an umlsterm, Behandlung is an umlsterm, kopfverletzten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Sehnervenschaeden is an umlsterm, Element is an umlsterm, Sehnervenschaeden is an umlsterm, Bewusstseinsgrad is an umlsterm, Patienten is an umlsterm, Sehnervenschaeden is an umlsterm, Therapie is an umlsterm, Arbeit is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Sehnervenschaeden is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Therapieerfolg is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Sehnervenschaedigung is an umlsterm	MundKieferGesichtschirurgie.8002s107.ger.abstr_task1	Sentence: Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen . Instructions: please typing these entity words according to sentence: Sehnervenschaeden, Behandlung, kopfverletzten, Patienten, Patienten, Sehnervenschaeden, Element, Sehnervenschaeden, Bewusstseinsgrad, Patienten, Sehnervenschaeden, Therapie, Arbeit, Patienten, Therapie, Sehnervenschaeden, Patienten, Therapie, Patienten, Patienten, Therapieerfolg, Patienten, Patienten, Behandlung, Sehnervenschaedigung Options: umlsterm	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen .	[ "Traumatische", "Sehnervenschaeden", "stellen", "eine", "klinische", "Herausforderung", "dar", ",", "da", "ihre", "Frueherkennung", "und", "Behandlung", "nicht", "systematisiert", "sind", ".", "Neuroophthalmologische", "Tests", "sind", "prinzipiell", "sichere", "Verfahren", "zur", "Feststellung", "eines", "Sehbahnschadens", ",", "jedoch", "koennen", "sie", "lediglich", "in", "ca", ".", "30", "%", "der", "schwer", "kopfverletzten", "Patienten", "erfolgreich", "angewendet", "werden", ";", "besonders", "bei", "polytraumatisierten", "Patienten", "sind", "Sehnervenschaeden", "schwer", "zu", "erheben", ".", "Wir", "haben", "mit", "Hilfe", "der", "bekannten", "Blitz", "-", "VEP", "ERG", "-", "Untersuchung", "ein", "sicheres", "diagnostisches", "Element", "zur", "Frueherkennung", "traumatischer", "Sehnervenschaeden", "unabhaengig", "vom", "Bewusstseinsgrad", "des", "Verletzten", "erarbeitet", ".", "Neben", "dem", "Problem", "der", "Frueherkennung", "besteht", "Unsicherheit", "im", "Hinblick", "auf", "eine", "klare", "therapeutische", "Richtlinie", "fuer", "Patienten", "mit", "traumatischen", "Sehnervenschaeden", "-", "konservative", "vs", ".", "chirurgische", "Therapie", ".", "Ziel", "dieser", "Arbeit", "war", "es", ",", "unabhaengig", "von", "der", "Kooperationsfaehigkeit", "des", "Patienten", "einen", "verlaesslichen", "Plan", "zur", "interdisziplinaeren", "Frueherkennung", "und", "Therapie", "traumatischer", "Sehnervenschaeden", "auf", "der", "Basis", "von", "neuroophthalmologischen", ",", "Spiral", "-", "CT-", "und", "neurophysiologischen", "Befunden", "zu", "erstellen", ",", "so", "dass", "fuer", "jeden", "Patienten", "eine", "klare", "Richtlinie", "fuer", "oder", "gegen", "eine", "Therapie", "vorliegt", ".", "Insgesamt", "wurden", "52", "Patienten", "mit", "Hilfe", "dieses", "diagnostischen", "Stufenplans", "untersucht", ";", "hiervon", "konnten", "bei", "insgesamt", "20", "Patienten", "posttraumatische", "afferente", "Sehbahnschaeden", "diagnostiziert", "werden", ".", "Obwohl", "der", "Beweis", "fuer", "einen", "Therapieerfolg", "nur", "schwer", "zu", "erbringen", "ist", ",", "konnte", "aus", "der", "Gruppe", "der", "kooperativen", "Patienten", "bei", "3", "einseitig", "amaurotischen", "Patienten", "nach", "unmittelbarer", "Einleitung", "der", "kombinierten", "konservativen", "und", "operativen", "Behandlung", "eine", "partielle", "Restitution", "der", "geschaedigten", "Sehbahnfunktion", "erzielt", "werden", ".", "In", "den", "meisten", "Kliniken", "wird", "nach", "wie", "vor", "das", "Problem", "der", "traumatischen", "Sehnervenschaedigung", "nach", "dem", "Wait", "-", "and", "-", "see", "-", "Prinzip", "angegangen", ".", "Wir", "halten", "ein", "solches", "Vorgehen", "fuer", "nicht", "gerechtfertigt", ",", "da", "es", "klare", "Alternativen", "gibt", ",", "die", "im", "folgenden", "vorgestellt", "werden", "sollen", "." ]	[ "umlsterm" ]
Sehnervenschaeden, Behandlung, kopfverletzten, Patienten, Patienten, Sehnervenschaeden, Element, Sehnervenschaeden, Bewusstseinsgrad, Patienten, Sehnervenschaeden, Therapie, Arbeit, Patienten, Therapie, Sehnervenschaeden, Patienten, Therapie, Patienten, Patienten, Therapieerfolg, Patienten, Patienten, Behandlung, Sehnervenschaedigung	MundKieferGesichtschirurgie.8002s107.ger.abstr_task2	Sentence: Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen .	[ "Traumatische", "Sehnervenschaeden", "stellen", "eine", "klinische", "Herausforderung", "dar", ",", "da", "ihre", "Frueherkennung", "und", "Behandlung", "nicht", "systematisiert", "sind", ".", "Neuroophthalmologische", "Tests", "sind", "prinzipiell", "sichere", "Verfahren", "zur", "Feststellung", "eines", "Sehbahnschadens", ",", "jedoch", "koennen", "sie", "lediglich", "in", "ca", ".", "30", "%", "der", "schwer", "kopfverletzten", "Patienten", "erfolgreich", "angewendet", "werden", ";", "besonders", "bei", "polytraumatisierten", "Patienten", "sind", "Sehnervenschaeden", "schwer", "zu", "erheben", ".", "Wir", "haben", "mit", "Hilfe", "der", "bekannten", "Blitz", "-", "VEP", "ERG", "-", "Untersuchung", "ein", "sicheres", "diagnostisches", "Element", "zur", "Frueherkennung", "traumatischer", "Sehnervenschaeden", "unabhaengig", "vom", "Bewusstseinsgrad", "des", "Verletzten", "erarbeitet", ".", "Neben", "dem", "Problem", "der", "Frueherkennung", "besteht", "Unsicherheit", "im", "Hinblick", "auf", "eine", "klare", "therapeutische", "Richtlinie", "fuer", "Patienten", "mit", "traumatischen", "Sehnervenschaeden", "-", "konservative", "vs", ".", "chirurgische", "Therapie", ".", "Ziel", "dieser", "Arbeit", "war", "es", ",", "unabhaengig", "von", "der", "Kooperationsfaehigkeit", "des", "Patienten", "einen", "verlaesslichen", "Plan", "zur", "interdisziplinaeren", "Frueherkennung", "und", "Therapie", "traumatischer", "Sehnervenschaeden", "auf", "der", "Basis", "von", "neuroophthalmologischen", ",", "Spiral", "-", "CT-", "und", "neurophysiologischen", "Befunden", "zu", "erstellen", ",", "so", "dass", "fuer", "jeden", "Patienten", "eine", "klare", "Richtlinie", "fuer", "oder", "gegen", "eine", "Therapie", "vorliegt", ".", "Insgesamt", "wurden", "52", "Patienten", "mit", "Hilfe", "dieses", "diagnostischen", "Stufenplans", "untersucht", ";", "hiervon", "konnten", "bei", "insgesamt", "20", "Patienten", "posttraumatische", "afferente", "Sehbahnschaeden", "diagnostiziert", "werden", ".", "Obwohl", "der", "Beweis", "fuer", "einen", "Therapieerfolg", "nur", "schwer", "zu", "erbringen", "ist", ",", "konnte", "aus", "der", "Gruppe", "der", "kooperativen", "Patienten", "bei", "3", "einseitig", "amaurotischen", "Patienten", "nach", "unmittelbarer", "Einleitung", "der", "kombinierten", "konservativen", "und", "operativen", "Behandlung", "eine", "partielle", "Restitution", "der", "geschaedigten", "Sehbahnfunktion", "erzielt", "werden", ".", "In", "den", "meisten", "Kliniken", "wird", "nach", "wie", "vor", "das", "Problem", "der", "traumatischen", "Sehnervenschaedigung", "nach", "dem", "Wait", "-", "and", "-", "see", "-", "Prinzip", "angegangen", ".", "Wir", "halten", "ein", "solches", "Vorgehen", "fuer", "nicht", "gerechtfertigt", ",", "da", "es", "klare", "Alternativen", "gibt", ",", "die", "im", "folgenden", "vorgestellt", "werden", "sollen", "." ]	[ "umlsterm" ]
estramustine is a CHEMICAL	1908244_task0	Sentence: The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent.	[ "The", "effect", "of", "estramustine", "derivatives", "on", "microtubule", "assembly", "in", "vitro", "depends", "on", "the", "charge", "of", "the", "substituent", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
estramustine is a CHEMICAL	1908244_task1	Sentence: The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent. Instructions: please typing these entity words according to sentence: estramustine Options: CHEMICAL	[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent.	[ "The", "effect", "of", "estramustine", "derivatives", "on", "microtubule", "assembly", "in", "vitro", "depends", "on", "the", "charge", "of", "the", "substituent", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
estramustine	1908244_task2	Sentence: The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent.	[ "The", "effect", "of", "estramustine", "derivatives", "on", "microtubule", "assembly", "in", "vitro", "depends", "on", "the", "charge", "of", "the", "substituent", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
binding site is a Entity, nuclear factor - kappaB is a Entity, NF - kappaB is a Entity, promoter region of the germline Cepsilon gene is a Entity, NF - kappaB is a Entity, germline Cepsilon is a Entity, n - acetyl - L - cysteine is a Entity, NAC is a Entity, NF - kappaB is a Entity, IL-4 is a Protein, CD40 is a Protein, IL-4 is a Protein, signal transducers and activators of transcription ( STAT ) 6 is a Protein, NF - kappaB is a Entity, NAC is a Entity, decoy oligodeoxynucleotides is a Entity, NF - kappaB is a Entity, STAT6 is a Protein, germline Cepsilon is a Entity, decoy oligodeoxynucleotides is a Entity, germline Cepsilon is a Entity, germline Cepsilon is a Entity, NAC is a Entity, decoy oligodeoxynucleotide is a Entity, NAC is a Entity, NAC is a Entity, IL-4 is a Protein, CD40 is a Protein, CD40 is a Protein, CD23 is a Protein, NF - kappaB is a Entity, STAT6 is a Protein, germline Cepsilon is a Entity, IL-4 is a Protein, NF - kappaB is a Entity, germline Cepsilon is a Entity	798_task0	Sentence: A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB. The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE. 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The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE.	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binding site is a Entity, nuclear factor - kappaB is a Entity, NF - kappaB is a Entity, promoter region of the germline Cepsilon gene is a Entity, NF - kappaB is a Entity, germline Cepsilon is a Entity, n - acetyl - L - cysteine is a Entity, NAC is a Entity, NF - kappaB is a Entity, IL-4 is a Protein, CD40 is a Protein, IL-4 is a Protein, signal transducers and activators of transcription ( STAT ) 6 is a Protein, NF - kappaB is a Entity, NAC is a Entity, decoy oligodeoxynucleotides is a Entity, NF - kappaB is a Entity, STAT6 is a Protein, germline Cepsilon is a Entity, decoy oligodeoxynucleotides is a Entity, germline Cepsilon is a Entity, germline Cepsilon is a Entity, NAC is a Entity, decoy oligodeoxynucleotide is a Entity, NAC is a Entity, NAC is a Entity, IL-4 is a Protein, CD40 is a Protein, CD40 is a Protein, CD23 is a Protein, NF - kappaB is a Entity, STAT6 is a Protein, germline Cepsilon is a Entity, IL-4 is a Protein, NF - kappaB is a Entity, germline Cepsilon is a Entity	798_task1	Sentence: A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB. The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE. 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The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE.	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binding site, nuclear factor - kappaB, NF - kappaB, promoter region of the germline Cepsilon gene, NF - kappaB, germline Cepsilon, n - acetyl - L - cysteine, NAC, NF - kappaB, IL-4, CD40, IL-4, signal transducers and activators of transcription ( STAT ) 6, NF - kappaB, NAC, decoy oligodeoxynucleotides, NF - kappaB, STAT6, germline Cepsilon, decoy oligodeoxynucleotides, germline Cepsilon, germline Cepsilon, NAC, decoy oligodeoxynucleotide, NAC, NAC, IL-4, CD40, CD40, CD23, NF - kappaB, STAT6, germline Cepsilon, IL-4, NF - kappaB, germline Cepsilon	798_task2	Sentence: A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB. The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "I-Protein", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "B-Entity", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "B-Entity", "I-Entity", "I-Entity", "O", "B-Protein", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Entity", "I-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "I-Entity", "O", "O", "O", "O", "O", "O", "O" ]	A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB. The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE.	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adjuvant radiotherapy is a Procedure, intra - abdominal inflammation is a Condition, imaging and / or laboratory is a Scope, abscess or cholecystitis is a Scope, chronic pancreatitis is a Condition, pancreatic polypeptide producing endocrine tumor is a Condition, Poorly regulated is a Qualifier, diabetes is a Condition, > 200 mg / dl (= 11 mmol / l ) is a Qualifier	NCT02425774_exc_task0	Sentence: adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l)) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Scope, Condition, Procedure, Qualifier	[ "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O" ]	adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l))	[ "adjuvant", "radiotherapy", "\n", "evident", "intra", "-", "abdominal", "inflammation", "(", "diagnosed", "by", "imaging", "and", "/", "or", "laboratory", "results", ",", "including", "an", "abscess", "or", "cholecystitis", ")", "\n", "chronic", "pancreatitis", "\n", "pancreatic", "polypeptide", "producing", "endocrine", "tumor", "\n", "American", "Society", "of", "Anesthesiologists", "physical", "-", "health", "status", "classification", "(", "ASA", "-", "PS)>3", "\n", "Poorly", "regulated", "diabetes", "(", ">", "200", "mg", "/", "dl", "(=", "11", "mmol", "/", "l", ")", ")", "\n" ]	[ "Measurement", "Condition", "Scope", "Qualifier", "Procedure", "Multiplier", "Value" ]
adjuvant radiotherapy is a Procedure, intra - abdominal inflammation is a Condition, imaging and / or laboratory is a Scope, abscess or cholecystitis is a Scope, chronic pancreatitis is a Condition, pancreatic polypeptide producing endocrine tumor is a Condition, Poorly regulated is a Qualifier, diabetes is a Condition, > 200 mg / dl (= 11 mmol / l ) is a Qualifier	NCT02425774_exc_task1	Sentence: adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l)) Instructions: please typing these entity words according to sentence: adjuvant radiotherapy, intra - abdominal inflammation, imaging and / or laboratory, abscess or cholecystitis, chronic pancreatitis, pancreatic polypeptide producing endocrine tumor, Poorly regulated, diabetes, > 200 mg / dl (= 11 mmol / l ) Options: Scope, Condition, Procedure, Qualifier	[ "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O" ]	adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l))	[ "adjuvant", "radiotherapy", "\n", "evident", "intra", "-", "abdominal", "inflammation", "(", "diagnosed", "by", "imaging", "and", "/", "or", "laboratory", "results", ",", "including", "an", "abscess", "or", "cholecystitis", ")", "\n", "chronic", "pancreatitis", "\n", "pancreatic", "polypeptide", "producing", "endocrine", "tumor", "\n", "American", "Society", "of", "Anesthesiologists", "physical", "-", "health", "status", "classification", "(", "ASA", "-", "PS)>3", "\n", "Poorly", "regulated", "diabetes", "(", ">", "200", "mg", "/", "dl", "(=", "11", "mmol", "/", "l", ")", ")", "\n" ]	[ "Measurement", "Condition", "Scope", "Qualifier", "Procedure", "Multiplier", "Value" ]
adjuvant radiotherapy, intra - abdominal inflammation, imaging and / or laboratory, abscess or cholecystitis, chronic pancreatitis, pancreatic polypeptide producing endocrine tumor, Poorly regulated, diabetes, > 200 mg / dl (= 11 mmol / l )	NCT02425774_exc_task2	Sentence: adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l)) Instructions: please extract entity words from the input sentence	[ "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O" ]	adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l))	[ "adjuvant", "radiotherapy", "\n", "evident", "intra", "-", "abdominal", "inflammation", "(", "diagnosed", "by", "imaging", "and", "/", "or", "laboratory", "results", ",", "including", "an", "abscess", "or", "cholecystitis", ")", "\n", "chronic", "pancreatitis", "\n", "pancreatic", "polypeptide", "producing", "endocrine", "tumor", "\n", "American", "Society", "of", "Anesthesiologists", "physical", "-", "health", "status", "classification", "(", "ASA", "-", "PS)>3", "\n", "Poorly", "regulated", "diabetes", "(", ">", "200", "mg", "/", "dl", "(=", "11", "mmol", "/", "l", ")", ")", "\n" ]	[ "Measurement", "Condition", "Scope", "Qualifier", "Procedure", "Multiplier", "Value" ]
interleukin-8 is a Protein, Interleukin-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, MEK1 is a Protein, IL-8 is a Protein	9916078_task0	Sentence: Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.	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interleukin-8 is a Protein, Interleukin-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, MEK1 is a Protein, IL-8 is a Protein	9916078_task1	Sentence: Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. Instructions: please typing these entity words according to sentence: interleukin-8, Interleukin-8, IL-8, IL-8, IL-8, IL-8, MEK1, IL-8 Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.	[ "Involvement", "of", "mitogen", "-", "activated", "protein", "kinase", "pathways", "in", "interleukin-8", "production", "by", "human", "monocytes", "and", "polymorphonuclear", "cells", "stimulated", "with", "lipopolysaccharide", "or", "Mycoplasma", "fermentans", "membrane", "lipoproteins", ".", "\n", "Interleukin-8", "(", "IL-8", ")", "is", "a", "chemokine", "that", "belongs", "to", "the", "alpha", "-", "chemokine", "or", "CXC", "subfamily", "and", "is", "produced", "by", "a", "wide", "variety", "of", "human", "cells", ",", "including", "monocytes", "and", "polymorphonuclear", "cells", "(", "PMN", ")", ".", "IL-8", "is", "secreted", "in", "response", "to", "inflammatory", "stimuli", ",", "notably", "bacterial", "products", "such", "as", "lipopolysaccharide", "(", "LPS", ")", ",", "but", "little", "is", "known", "about", "the", "mechanisms", "by", "which", "these", "agents", "mediate", "IL-8", "induction", ".", "In", "this", "report", ",", "we", "show", "that", "Mycoplasma", "fermentans", "lipid", "-", "associated", "membrane", "proteins", "(", "LAMPf", ")", "induce", "the", "production", "of", "high", "levels", "of", "IL-8", "by", "THP-1", "(", "human", "monocyte", ")", "cells", "and", "PMN", "at", "the", "same", "extent", "as", "LPS", ".", "It", "was", "previously", "demonstrated", "that", "stimulation", "of", "monocytic", "cells", "with", "either", "LPS", "or", "LAMPf", "led", "to", "a", "series", "of", "common", "downstream", "signaling", "events", ",", "including", "the", "activation", "of", "protein", "tyrosine", "kinase", "and", "of", "mitogen", "-", "activated", "protein", "kinase", "cascades", ".", "By", "using", "PD-98059", "and", "SB203580", ",", "two", "potent", "and", "selective", "inhibitors", "of", "MEK1", "(", "a", "kinase", "upstream", "of", "ERK1/2", ")", "and", "p38", ",", "respectively", ",", "we", "have", "demonstrated", "that", "both", "ERK1/2", "and", "p38", "cascades", "play", "a", "key", "role", "in", "the", "production", "of", "IL-8", "by", "monocytes", "and", "PMN", "stimulated", "with", "bacterial", "fractions", "." ]	[ "Protein" ]
interleukin-8, Interleukin-8, IL-8, IL-8, IL-8, IL-8, MEK1, IL-8	9916078_task2	Sentence: Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.	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wogonin is a CHEMICAL	23219337_task0	Sentence: Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.	[ "Anti", "-", "tumor", "and", "anti", "-", "metastatic", "actions", "of", "wogonin", "isolated", "from", "Scutellaria", "baicalensis", "roots", "through", "anti", "-", "lymphangiogenesis", "." ]	[ "GENE-Y", "CHEMICAL" ]
wogonin is a CHEMICAL	23219337_task1	Sentence: Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. Instructions: please typing these entity words according to sentence: wogonin Options: CHEMICAL	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.	[ "Anti", "-", "tumor", "and", "anti", "-", "metastatic", "actions", "of", "wogonin", "isolated", "from", "Scutellaria", "baicalensis", "roots", "through", "anti", "-", "lymphangiogenesis", "." ]	[ "GENE-Y", "CHEMICAL" ]
wogonin	23219337_task2	Sentence: Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.	[ "Anti", "-", "tumor", "and", "anti", "-", "metastatic", "actions", "of", "wogonin", "isolated", "from", "Scutellaria", "baicalensis", "roots", "through", "anti", "-", "lymphangiogenesis", "." ]	[ "GENE-Y", "CHEMICAL" ]
tamsulone - FS is a Intervention_Pharmacological, prostatic adenoma is a Participant_Condition, Tamsulone - FS -- is a Intervention_Pharmacological, prostatic adenoma . is a Outcome_Physical, efficacy and safety for management of lower urinary tract symptoms is a Outcome_Other, The efficacy and safety of tamsulone - FS was comparable to those of omnik . is a Outcome_Other	27432_task0	Sentence: [ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Intervention_Pharmacological, Outcome_Physical, Participant_Condition	[ "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	[ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale .	[ "[", "Pilot", "results", "of", "using", "tamsulone", "-", "FS", "in", "patients", "with", "prostatic", "adenoma", "according", "to", "the", "results", "of", "a", "randomized", "multicenter", "comparative", "trial", "]", ".", "Tamsulone", "-", "FS", "--", "a", "novel", "Russian", "alpha1A", "/", "D", "-", "adrenoblocker", "(", "Farm", "-", "Syntez", ")", "--", "was", "studied", "in", "a", "randomized", "multicenter", "comparative", "trial", "in", "patients", "with", "prostatic", "adenoma", ".", "Pilot", "results", "agreed", "with", "other", "trials", "published", "in", "the", "literature", "and", "demonstrated", "tamsulone", "-", "FS", "efficacy", "and", "safety", "for", "management", "of", "lower", "urinary", "tract", "symptoms", "caused", "by", "prostatic", "adenoma", ".", "The", "efficacy", "and", "safety", "of", "tamsulone", "-", "FS", "was", "comparable", "to", "those", "of", "omnik", ".", "This", "drug", "can", "be", "recommended", "for", "wide", "clinical", "practice", "in", "prostatic", "adenoma", ".", "It", "is", "registered", "by", "Roszdravnadzor", "(", "certificate", "N", "LC-000859", "of", "03.11.2005", ")", "and", "allowed", "for", "production", "and", "sale", "." ]	[ "Outcome_Other", "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]
tamsulone - FS is a Intervention_Pharmacological, prostatic adenoma is a Participant_Condition, Tamsulone - FS -- is a Intervention_Pharmacological, prostatic adenoma . is a Outcome_Physical, efficacy and safety for management of lower urinary tract symptoms is a Outcome_Other, The efficacy and safety of tamsulone - FS was comparable to those of omnik . is a Outcome_Other	27432_task1	Sentence: [ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale . Instructions: please typing these entity words according to sentence: tamsulone - FS, prostatic adenoma, Tamsulone - FS --, prostatic adenoma ., efficacy and safety for management of lower urinary tract symptoms, The efficacy and safety of tamsulone - FS was comparable to those of omnik . Options: Outcome_Other, Intervention_Pharmacological, Outcome_Physical, Participant_Condition	[ "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	[ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale .	[ "[", "Pilot", "results", "of", "using", "tamsulone", "-", "FS", "in", "patients", "with", "prostatic", "adenoma", "according", "to", "the", "results", "of", "a", "randomized", "multicenter", "comparative", "trial", "]", ".", "Tamsulone", "-", "FS", "--", "a", "novel", "Russian", "alpha1A", "/", "D", "-", "adrenoblocker", "(", "Farm", "-", "Syntez", ")", "--", "was", "studied", "in", "a", "randomized", "multicenter", "comparative", "trial", "in", "patients", "with", "prostatic", "adenoma", ".", "Pilot", "results", "agreed", "with", "other", "trials", "published", "in", "the", "literature", "and", "demonstrated", "tamsulone", "-", "FS", "efficacy", "and", "safety", "for", "management", "of", "lower", "urinary", "tract", "symptoms", "caused", "by", "prostatic", "adenoma", ".", "The", "efficacy", "and", "safety", "of", "tamsulone", "-", "FS", "was", "comparable", "to", "those", "of", "omnik", ".", "This", "drug", "can", "be", "recommended", "for", "wide", "clinical", "practice", "in", "prostatic", "adenoma", ".", "It", "is", "registered", "by", "Roszdravnadzor", "(", "certificate", "N", "LC-000859", "of", "03.11.2005", ")", "and", "allowed", "for", "production", "and", "sale", "." ]	[ "Outcome_Other", "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]
tamsulone - FS, prostatic adenoma, Tamsulone - FS --, prostatic adenoma ., efficacy and safety for management of lower urinary tract symptoms, The efficacy and safety of tamsulone - FS was comparable to those of omnik .	27432_task2	Sentence: [ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	[ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale .	[ "[", "Pilot", "results", "of", "using", "tamsulone", "-", "FS", "in", "patients", "with", "prostatic", "adenoma", "according", "to", "the", "results", "of", "a", "randomized", "multicenter", "comparative", "trial", "]", ".", "Tamsulone", "-", "FS", "--", "a", "novel", "Russian", "alpha1A", "/", "D", "-", "adrenoblocker", "(", "Farm", "-", "Syntez", ")", "--", "was", "studied", "in", "a", "randomized", "multicenter", "comparative", "trial", "in", "patients", "with", "prostatic", "adenoma", ".", "Pilot", "results", "agreed", "with", "other", "trials", "published", "in", "the", "literature", "and", "demonstrated", "tamsulone", "-", "FS", "efficacy", "and", "safety", "for", "management", "of", "lower", "urinary", "tract", "symptoms", "caused", "by", "prostatic", "adenoma", ".", "The", "efficacy", "and", "safety", "of", "tamsulone", "-", "FS", "was", "comparable", "to", "those", "of", "omnik", ".", "This", "drug", "can", "be", "recommended", "for", "wide", "clinical", "practice", "in", "prostatic", "adenoma", ".", "It", "is", "registered", "by", "Roszdravnadzor", "(", "certificate", "N", "LC-000859", "of", "03.11.2005", ")", "and", "allowed", "for", "production", "and", "sale", "." ]	[ "Outcome_Other", "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]
care is an umlsterm, dance is an umlsterm, joint is an umlsterm, MTP is an umlsterm, dorsiflexion is an umlsterm, great toe is an umlsterm, anatomical is an umlsterm, cadaver is an umlsterm, arthroscopy is an umlsterm, MTP is an umlsterm, University is an umlsterm, procedures is an umlsterm, patients is an umlsterm, operations is an umlsterm, hallux rigidus is an umlsterm, syndrome is an umlsterm, painful joint is an umlsterm, dorsiflexion is an umlsterm, osteochondrosis is an umlsterm, sesamoid bone is an umlsterm, prospective study is an umlsterm, function is an umlsterm, pain is an umlsterm, ability is an umlsterm, sport is an umlsterm, surgery is an umlsterm, patients is an umlsterm, syndromes is an umlsterm, osteochondrosis is an umlsterm, surgery is an umlsterm, hallux rigidus is an umlsterm, sesamoid bone is an umlsterm, pathology is an umlsterm, procedure is an umlsterm, MTP is an umlsterm, Arthroscopy is an umlsterm, MTP is an umlsterm	Arthroskopie.80110283.eng.abstr_task0	Sentence: In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications .	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care is an umlsterm, dance is an umlsterm, joint is an umlsterm, MTP is an umlsterm, dorsiflexion is an umlsterm, great toe is an umlsterm, anatomical is an umlsterm, cadaver is an umlsterm, arthroscopy is an umlsterm, MTP is an umlsterm, University is an umlsterm, procedures is an umlsterm, patients is an umlsterm, operations is an umlsterm, hallux rigidus is an umlsterm, syndrome is an umlsterm, painful joint is an umlsterm, dorsiflexion is an umlsterm, osteochondrosis is an umlsterm, sesamoid bone is an umlsterm, prospective study is an umlsterm, function is an umlsterm, pain is an umlsterm, ability is an umlsterm, sport is an umlsterm, surgery is an umlsterm, patients is an umlsterm, syndromes is an umlsterm, osteochondrosis is an umlsterm, surgery is an umlsterm, hallux rigidus is an umlsterm, sesamoid bone is an umlsterm, pathology is an umlsterm, procedure is an umlsterm, MTP is an umlsterm, Arthroscopy is an umlsterm, MTP is an umlsterm	Arthroskopie.80110283.eng.abstr_task1	Sentence: In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications . Instructions: please typing these entity words according to sentence: care, dance, joint, MTP, dorsiflexion, great toe, anatomical, cadaver, arthroscopy, MTP, University, procedures, patients, operations, hallux rigidus, syndrome, painful joint, dorsiflexion, osteochondrosis, sesamoid bone, prospective study, function, pain, ability, sport, surgery, patients, syndromes, osteochondrosis, surgery, hallux rigidus, sesamoid bone, pathology, procedure, MTP, Arthroscopy, MTP Options: umlsterm	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications .	[ "In", "the", "medical", "care", "of", "a", "professional", "dance", "group", "we", "were", "often", "confronted", "with", "problems", "of", "the", "first", "metatarsophalangeal", "joint", "(", "MTP", "I", ")", ".", "A", "painful", ",", "limited", "dorsiflexion", "of", "the", "great", "toe", "makes", "classical", "ballet", "performance", "virtually", "impossible", ".", "After", "anatomical", "cadaver", "studies", "we", "introduced", "arthroscopy", "of", "MTP", "I", "at", "the", "Orthopaedic", "Department", "of", "the", "Academic", "Medical", "Centre", "of", "the", "University", "of", "Amsterdam", "in", "1990", ".", "By", "1992", "arthroscopic", "procedures", "had", "been", "performed", "in", "23", "patients", ".", "The", "indications", "for", "the", "operations", "were", ":", "(", "1", ")", "hallux", "rigidus", "(", "n", "=", "4", ")", ",", "(", "2", ")", "impingement", "syndrome", "(", "painful", "joint", "with", "slightly", "limited", "dorsiflexion", ";", "n", "=", "11", ")", ",", "(", "3", ")", "osteochondrosis", "dissecans", "/", "loose", "bodies", "(", "n", "=", "3", ")", ",", "and", "(", "4", ")", "pathological", "conditions", "in", "sesamoid", "bone", "(", "n", "=", "5", ")", ".", "The", "result", "of", "this", "prospective", "study", "were", "analysed", "in", "respect", "of", "function", ",", "pain", ",", "swelling", ",", "ability", "to", "work", "and", "sport", "performance", ".", "The", "best", "results", "of", "arthroscopic", "surgery", "were", "seen", "in", "patients", "with", "impingement", "syndromes", "and", "in", "osteochondrosis", "dissecans", "or", "loose", "bodies", ".", "The", "results", "of", "arthroscopic", "surgery", "of", "the", "hallux", "rigidus", "and", "the", "sesamoid", "bone", "pathology", "were", "less", "favourable", ".", "The", "results", "of", "our", "new", "arthroscopic", "procedure", "on", "MTP", "I", "are", "encouraging", ".", "Arthroscopy", "of", "the", "MTP", "I", "can", "be", "advised", "for", "suitable", "indications", "." ]	[ "umlsterm" ]
care, dance, joint, MTP, dorsiflexion, great toe, anatomical, cadaver, arthroscopy, MTP, University, procedures, patients, operations, hallux rigidus, syndrome, painful joint, dorsiflexion, osteochondrosis, sesamoid bone, prospective study, function, pain, ability, sport, surgery, patients, syndromes, osteochondrosis, surgery, hallux rigidus, sesamoid bone, pathology, procedure, MTP, Arthroscopy, MTP	Arthroskopie.80110283.eng.abstr_task2	Sentence: In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]	In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications .	[ "In", "the", "medical", "care", "of", "a", "professional", "dance", "group", "we", "were", "often", "confronted", "with", "problems", "of", "the", "first", "metatarsophalangeal", "joint", "(", "MTP", "I", ")", ".", "A", "painful", ",", "limited", "dorsiflexion", "of", "the", "great", "toe", "makes", "classical", "ballet", "performance", "virtually", "impossible", ".", "After", "anatomical", "cadaver", "studies", "we", "introduced", "arthroscopy", "of", "MTP", "I", "at", "the", "Orthopaedic", "Department", "of", "the", "Academic", "Medical", "Centre", "of", "the", "University", "of", "Amsterdam", "in", "1990", ".", "By", "1992", "arthroscopic", "procedures", "had", "been", "performed", "in", "23", "patients", ".", "The", "indications", "for", "the", "operations", "were", ":", "(", "1", ")", "hallux", "rigidus", "(", "n", "=", "4", ")", ",", "(", "2", ")", "impingement", "syndrome", "(", "painful", "joint", "with", "slightly", "limited", "dorsiflexion", ";", "n", "=", "11", ")", ",", "(", "3", ")", "osteochondrosis", "dissecans", "/", "loose", "bodies", "(", "n", "=", "3", ")", ",", "and", "(", "4", ")", "pathological", "conditions", "in", "sesamoid", "bone", "(", "n", "=", "5", ")", ".", "The", "result", "of", "this", "prospective", "study", "were", "analysed", "in", "respect", "of", "function", ",", "pain", ",", "swelling", ",", "ability", "to", "work", "and", "sport", "performance", ".", "The", "best", "results", "of", "arthroscopic", "surgery", "were", "seen", "in", "patients", "with", "impingement", "syndromes", "and", "in", "osteochondrosis", "dissecans", "or", "loose", "bodies", ".", "The", "results", "of", "arthroscopic", "surgery", "of", "the", "hallux", "rigidus", "and", "the", "sesamoid", "bone", "pathology", "were", "less", "favourable", ".", "The", "results", "of", "our", "new", "arthroscopic", "procedure", "on", "MTP", "I", "are", "encouraging", ".", "Arthroscopy", "of", "the", "MTP", "I", "can", "be", "advised", "for", "suitable", "indications", "." ]	[ "umlsterm" ]
human carbonyl reductase 1 is a GENE-Y, CBR1 is a GENE-Y, SDR21C1 is a GENE-Y, Nrf2 is a GENE-Y	23247010_task0	Sentence: Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y	[ "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "O" ]	Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.	[ "Regulation", "of", "human", "carbonyl", "reductase", "1", "(", "CBR1", ",", "SDR21C1", ")", "gene", "by", "transcription", "factor", "Nrf2", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
human carbonyl reductase 1 is a GENE-Y, CBR1 is a GENE-Y, SDR21C1 is a GENE-Y, Nrf2 is a GENE-Y	23247010_task1	Sentence: Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2. Instructions: please typing these entity words according to sentence: human carbonyl reductase 1, CBR1, SDR21C1, Nrf2 Options: GENE-Y	[ "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "O" ]	Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.	[ "Regulation", "of", "human", "carbonyl", "reductase", "1", "(", "CBR1", ",", "SDR21C1", ")", "gene", "by", "transcription", "factor", "Nrf2", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
human carbonyl reductase 1, CBR1, SDR21C1, Nrf2	23247010_task2	Sentence: Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2. Instructions: please extract entity words from the input sentence	[ "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "O" ]	Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.	[ "Regulation", "of", "human", "carbonyl", "reductase", "1", "(", "CBR1", ",", "SDR21C1", ")", "gene", "by", "transcription", "factor", "Nrf2", "." ]	[ "GENE-N", "GENE-Y", "CHEMICAL" ]
serotonin receptor is a GENE-N, tricyclic is a CHEMICAL, guanine nucleotide - binding protein - coupled receptor is a GENE-N, serotonin receptors is a GENE-N, serotonin [ 5-hydroxytryptamine ( 5-HT ) ] receptors is a GENE-N, 5-HT2 is a GENE-Y, 5-HT1D is a GENE-Y, 5-HT1C is a GENE-Y, 5-HT1B is a GENE-Y, 5-HT1A is a GENE-Y, ( + ) -[2 - 125I ] iodolysergic acid diethylamide is a CHEMICAL, [ 125I]LSD is a CHEMICAL, 5-HT is a CHEMICAL, [ 125I]LSD is a CHEMICAL, [ 125I]LSD is a CHEMICAL, serotonin receptor is a GENE-N, tricyclic is a CHEMICAL, clozapine is a CHEMICAL, amoxipine is a CHEMICAL, amitriptyline is a CHEMICAL, serotonin is a CHEMICAL, adenylyl cyclase is a GENE-N, serotonin receptor is a GENE-N, tricyclic is a CHEMICAL	20794_task0	Sentence: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems.	[ "Cloning", "and", "expression", "of", "a", "novel", "serotonin", "receptor", "with", "high", "affinity", "for", "tricyclic", "psychotropic", "drugs", ".", "\n", "We", "have", "used", "the", "polymerase", "chain", "reaction", "technique", "to", "selectively", "amplify", "a", "guanine", "nucleotide", "-", "binding", "protein", "-", "coupled", "receptor", "cDNA", "sequence", "from", "rat", "striatal", "mRNA", "that", "exhibits", "high", "homology", "to", "previously", "cloned", "serotonin", "receptors", ".", "Sequencing", "of", "a", "full", "length", "clone", "isolated", "from", "a", "rat", "striatal", "cDNA", "library", "revealed", "an", "open", "reading", "frame", "of", "1311", "base", "pairs", ",", "encoding", "a", "437-residue", "protein", "with", "seven", "hydrophobic", "regions", ".", "Within", "these", "hydrophobic", "regions", ",", "this", "receptor", "was", "found", "to", "be", "41", "-", "36", "%", "identical", "to", "the", "following", "serotonin", "[", "5-hydroxytryptamine", "(", "5-HT", ")", "]", "receptors", ":", "5-HT2", ">", "5-HT1D", ">", "5-HT1C", ">", "5-HT1B", ">", "5-HT1A", ">", "5-HT1E.", "Northern", "blots", "revealed", "a", "approximately", "4.2-kilobase", "transcript", "localized", "in", "various", "brain", "regions", ",", "with", "the", "following", "rank", "order", "of", "abundance", ":", "striatum", ">", ">", "olfactory", "tubercle", ">", "cerebral", "cortex", ">", "hippocampus", ".", "Expression", "of", "this", "clone", "in", "COS-7", "cells", "resulted", "in", "the", "appearance", "of", "high", "affinity", ",", "saturable", "binding", "of", "(", "+", ")", "-[2", "-", "125I", "]", "iodolysergic", "acid", "diethylamide", "(", "[", "125I]LSD", ")", "with", "a", "Kd", "of", "1.26", "nM.", "Among", "endogenous", "biogenic", "amines", ",", "only", "5-HT", "completely", "inhibited", "[", "125I]LSD", "binding", "(", "Ki", "=", "150", "nM", ")", ".", "The", "inhibition", "of", "[", "125I]LSD", "binding", "by", "other", "serotonergic", "agonists", "and", "antagonists", "revealed", "a", "pharmacological", "profile", "that", "does", "not", "correlate", "with", "that", "of", "any", "previously", "described", "serotonin", "receptor", "subtype", ".", "In", "addition", ",", "this", "receptor", "exhibits", "high", "affinity", "for", "a", "number", "of", "tricyclic", "antipsychotic", "and", "antidepressant", "drugs", ",", "including", "clozapine", ",", "amoxipine", ",", "and", "amitriptyline", ".", "In", "HEK-293", "cells", "stably", "transfected", "with", "this", "receptor", ",", "serotonin", "elicits", "a", "potent", "stimulation", "of", "adenylyl", "cyclase", "activity", ",", "which", "is", "blocked", "by", "antipsychotic", "and", "antidepressant", "drugs", ".", "The", "distinct", "structural", "and", "pharmacological", "properties", "of", "this", "receptor", "site", "indicate", "that", "it", "represents", "a", "completely", "novel", "subtype", "of", "serotonin", "receptor", ".", "Based", "on", "its", "affinity", "for", "tricyclic", "psychotropic", "drugs", "and", "its", "localization", "to", "limbic", "and", "cortical", "regions", "of", "the", "brain", ",", "it", "is", "likely", "that", "this", "receptor", "may", "play", "a", "role", "in", "several", "neuropsychiatric", "disorders", "that", "involve", "serotonergic", "systems", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
serotonin receptor is a GENE-N, tricyclic is a CHEMICAL, guanine nucleotide - binding protein - coupled receptor is a GENE-N, serotonin receptors is a GENE-N, serotonin [ 5-hydroxytryptamine ( 5-HT ) ] receptors is a GENE-N, 5-HT2 is a GENE-Y, 5-HT1D is a GENE-Y, 5-HT1C is a GENE-Y, 5-HT1B is a GENE-Y, 5-HT1A is a GENE-Y, ( + ) -[2 - 125I ] iodolysergic acid diethylamide is a CHEMICAL, [ 125I]LSD is a CHEMICAL, 5-HT is a CHEMICAL, [ 125I]LSD is a CHEMICAL, [ 125I]LSD is a CHEMICAL, serotonin receptor is a GENE-N, tricyclic is a CHEMICAL, clozapine is a CHEMICAL, amoxipine is a CHEMICAL, amitriptyline is a CHEMICAL, serotonin is a CHEMICAL, adenylyl cyclase is a GENE-N, serotonin receptor is a GENE-N, tricyclic is a CHEMICAL	20794_task1	Sentence: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems. Instructions: please typing these entity words according to sentence: serotonin receptor, tricyclic, guanine nucleotide - binding protein - coupled receptor, serotonin receptors, serotonin [ 5-hydroxytryptamine ( 5-HT ) ] receptors, 5-HT2, 5-HT1D, 5-HT1C, 5-HT1B, 5-HT1A, ( + ) -[2 - 125I ] iodolysergic acid diethylamide, [ 125I]LSD, 5-HT, [ 125I]LSD, [ 125I]LSD, serotonin receptor, tricyclic, clozapine, amoxipine, amitriptyline, serotonin, adenylyl cyclase, serotonin receptor, tricyclic Options: GENE-Y, GENE-N, CHEMICAL	[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems.	[ "Cloning", "and", "expression", "of", "a", "novel", "serotonin", "receptor", "with", "high", "affinity", "for", "tricyclic", "psychotropic", "drugs", ".", "\n", "We", "have", "used", "the", "polymerase", "chain", "reaction", "technique", "to", "selectively", "amplify", "a", "guanine", "nucleotide", "-", "binding", "protein", "-", "coupled", "receptor", "cDNA", "sequence", "from", "rat", "striatal", "mRNA", "that", "exhibits", "high", "homology", "to", "previously", "cloned", "serotonin", "receptors", ".", "Sequencing", "of", "a", "full", "length", "clone", "isolated", "from", "a", "rat", "striatal", "cDNA", "library", "revealed", "an", "open", "reading", "frame", "of", "1311", "base", "pairs", ",", "encoding", "a", "437-residue", "protein", "with", "seven", "hydrophobic", "regions", ".", "Within", "these", "hydrophobic", "regions", ",", "this", "receptor", "was", "found", "to", "be", "41", "-", "36", "%", "identical", "to", "the", "following", "serotonin", "[", "5-hydroxytryptamine", "(", "5-HT", ")", "]", "receptors", ":", "5-HT2", ">", "5-HT1D", ">", "5-HT1C", ">", "5-HT1B", ">", "5-HT1A", ">", "5-HT1E.", "Northern", "blots", "revealed", "a", "approximately", "4.2-kilobase", "transcript", "localized", "in", "various", "brain", "regions", ",", "with", "the", "following", "rank", "order", "of", "abundance", ":", "striatum", ">", ">", "olfactory", "tubercle", ">", "cerebral", "cortex", ">", "hippocampus", ".", "Expression", "of", "this", "clone", "in", "COS-7", "cells", "resulted", "in", "the", "appearance", "of", "high", "affinity", ",", "saturable", "binding", "of", "(", "+", ")", "-[2", "-", "125I", "]", "iodolysergic", "acid", "diethylamide", "(", "[", "125I]LSD", ")", "with", "a", "Kd", "of", "1.26", "nM.", "Among", "endogenous", "biogenic", "amines", ",", "only", "5-HT", "completely", "inhibited", "[", "125I]LSD", "binding", "(", "Ki", "=", "150", "nM", ")", ".", "The", "inhibition", "of", "[", "125I]LSD", "binding", "by", "other", "serotonergic", "agonists", "and", "antagonists", "revealed", "a", "pharmacological", "profile", "that", "does", "not", "correlate", "with", "that", "of", "any", "previously", "described", "serotonin", "receptor", "subtype", ".", "In", "addition", ",", "this", "receptor", "exhibits", "high", "affinity", "for", "a", "number", "of", "tricyclic", "antipsychotic", "and", "antidepressant", "drugs", ",", "including", "clozapine", ",", "amoxipine", ",", "and", "amitriptyline", ".", "In", "HEK-293", "cells", "stably", "transfected", "with", "this", "receptor", ",", "serotonin", "elicits", "a", "potent", "stimulation", "of", "adenylyl", "cyclase", "activity", ",", "which", "is", "blocked", "by", "antipsychotic", "and", "antidepressant", "drugs", ".", "The", "distinct", "structural", "and", "pharmacological", "properties", "of", "this", "receptor", "site", "indicate", "that", "it", "represents", "a", "completely", "novel", "subtype", "of", "serotonin", "receptor", ".", "Based", "on", "its", "affinity", "for", "tricyclic", "psychotropic", "drugs", "and", "its", "localization", "to", "limbic", "and", "cortical", "regions", "of", "the", "brain", ",", "it", "is", "likely", "that", "this", "receptor", "may", "play", "a", "role", "in", "several", "neuropsychiatric", "disorders", "that", "involve", "serotonergic", "systems", "." ]	[ "GENE-N", "CHEMICAL", "GENE-Y" ]
serotonin receptor, tricyclic, guanine nucleotide - binding protein - coupled receptor, serotonin receptors, serotonin [ 5-hydroxytryptamine ( 5-HT ) ] receptors, 5-HT2, 5-HT1D, 5-HT1C, 5-HT1B, 5-HT1A, ( + ) -[2 - 125I ] iodolysergic acid diethylamide, [ 125I]LSD, 5-HT, [ 125I]LSD, [ 125I]LSD, serotonin receptor, tricyclic, clozapine, amoxipine, amitriptyline, serotonin, adenylyl cyclase, serotonin receptor, tricyclic	20794_task2	Sentence: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "I-GENE-N", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "I-CHEMICAL", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "I-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "B-CHEMICAL", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-GENE-N", "I-GENE-N", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems.	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HMSN is an umlsterm, Menschen is an umlsterm, Mutationen is an umlsterm, Genen is an umlsterm, Gene is an umlsterm, Proteinprodukte is an umlsterm, peripheren Nervensystems is an umlsterm, Kommunikation is an umlsterm, Diagnose is an umlsterm, praenatale Diagnostik is an umlsterm, Prognose is an umlsterm, Pathophysiologie is an umlsterm	DerNervenarzt.60670987.ger.abstr_task0	Sentence: Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten .	[ "Hereditaere", "motorische", "und", "sensible", "Neuropathien", "(", "HMSN", ")", "zaehlen", "zu", "den", "haeufigsten", "vererbbaren", "Erkrankungen", "des", "Menschen", ".", "In", "den", "letzten", "Jahren", "wurden", "Mutationen", "in", "verschiedenen", "Genen", "gefunden", ",", "die", "als", "ursaechlich", "fuer", "die", "Entstehung", "der", "hereditaeren", "Neuropathien", "angesehen", "werden", "muessen", ".", "Es", "handelt", "sich", "um", "Gene", ",", "deren", "Proteinprodukte", "zum", "einen", "Bausteine", "des", "Myelins", "des", "peripheren", "Nervensystems", "darstellen", "und", "zum", "anderen", "ein", "Gap", "-", "junction", "-", "Protein", "bilden", ",", "das", "die", "intra-", "und", "interzellulare", "Kommunikation", "ermoeglicht", ".", "Es", "ist", "nicht", "bekannt", ",", "ueber", "welche", "Zwischenschritte", "die", "einzelnen", "genetischen", "Veraenderungen", "zum", "jeweiligen", "Krankheitsphaenotyp", "fuehren", ".", "Die", "Pathogenese", "ist", "also", "noch", "nicht", "in", "allen", "Einzelheiten", "aufgeklaert", ".", "Die", "molekulargenetischen", "Befunde", "erlauben", "in", "den", "weitaus", "meisten", "Faellen", "eine", "exakte", "Diagnose", "auch", "ohne", "Zuhilfenahme", "histologischer", "Untersuchungen", ".", "Ebenso", "ist", "eine", "praenatale", "Diagnostik", "moeglich", ",", "deren", "Wertigkeit", "wegen", "der", "erheblichen", "Varianz", "der", "spaeteren", "Prognose", "des", "Krankheitsphaenotyps", "jedoch", "gering", "ist", ".", "Durch", "die", "Aufklaerung", "der", "Pathophysiologie", "sind", "neue", "individualtherapeutisch", "einsetzbare", ",", "effektive", "Behandlungsmoeglichkeiten", ",", "zu", "erwarten", "." ]	[ "umlsterm" ]
HMSN is an umlsterm, Menschen is an umlsterm, Mutationen is an umlsterm, Genen is an umlsterm, Gene is an umlsterm, Proteinprodukte is an umlsterm, peripheren Nervensystems is an umlsterm, Kommunikation is an umlsterm, Diagnose is an umlsterm, praenatale Diagnostik is an umlsterm, Prognose is an umlsterm, Pathophysiologie is an umlsterm	DerNervenarzt.60670987.ger.abstr_task1	Sentence: Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten . Instructions: please typing these entity words according to sentence: HMSN, Menschen, Mutationen, Genen, Gene, Proteinprodukte, peripheren Nervensystems, Kommunikation, Diagnose, praenatale Diagnostik, Prognose, Pathophysiologie Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten .	[ "Hereditaere", "motorische", "und", "sensible", "Neuropathien", "(", "HMSN", ")", "zaehlen", "zu", "den", "haeufigsten", "vererbbaren", "Erkrankungen", "des", "Menschen", ".", "In", "den", "letzten", "Jahren", "wurden", "Mutationen", "in", "verschiedenen", "Genen", "gefunden", ",", "die", "als", "ursaechlich", "fuer", "die", "Entstehung", "der", "hereditaeren", "Neuropathien", "angesehen", "werden", "muessen", ".", "Es", "handelt", "sich", "um", "Gene", ",", "deren", "Proteinprodukte", "zum", "einen", "Bausteine", "des", "Myelins", "des", "peripheren", "Nervensystems", "darstellen", "und", "zum", "anderen", "ein", "Gap", "-", "junction", "-", "Protein", "bilden", ",", "das", "die", "intra-", "und", "interzellulare", "Kommunikation", "ermoeglicht", ".", "Es", "ist", "nicht", "bekannt", ",", "ueber", "welche", "Zwischenschritte", "die", "einzelnen", "genetischen", "Veraenderungen", "zum", "jeweiligen", "Krankheitsphaenotyp", "fuehren", ".", "Die", "Pathogenese", "ist", "also", "noch", "nicht", "in", "allen", "Einzelheiten", "aufgeklaert", ".", "Die", "molekulargenetischen", "Befunde", "erlauben", "in", "den", "weitaus", "meisten", "Faellen", "eine", "exakte", "Diagnose", "auch", "ohne", "Zuhilfenahme", "histologischer", "Untersuchungen", ".", "Ebenso", "ist", "eine", "praenatale", "Diagnostik", "moeglich", ",", "deren", "Wertigkeit", "wegen", "der", "erheblichen", "Varianz", "der", "spaeteren", "Prognose", "des", "Krankheitsphaenotyps", "jedoch", "gering", "ist", ".", "Durch", "die", "Aufklaerung", "der", "Pathophysiologie", "sind", "neue", "individualtherapeutisch", "einsetzbare", ",", "effektive", "Behandlungsmoeglichkeiten", ",", "zu", "erwarten", "." ]	[ "umlsterm" ]
HMSN, Menschen, Mutationen, Genen, Gene, Proteinprodukte, peripheren Nervensystems, Kommunikation, Diagnose, praenatale Diagnostik, Prognose, Pathophysiologie	DerNervenarzt.60670987.ger.abstr_task2	Sentence: Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten .	[ "Hereditaere", "motorische", "und", "sensible", "Neuropathien", "(", "HMSN", ")", "zaehlen", "zu", "den", "haeufigsten", "vererbbaren", "Erkrankungen", "des", "Menschen", ".", "In", "den", "letzten", "Jahren", "wurden", "Mutationen", "in", "verschiedenen", "Genen", "gefunden", ",", "die", "als", "ursaechlich", "fuer", "die", "Entstehung", "der", "hereditaeren", "Neuropathien", "angesehen", "werden", "muessen", ".", "Es", "handelt", "sich", "um", "Gene", ",", "deren", "Proteinprodukte", "zum", "einen", "Bausteine", "des", "Myelins", "des", "peripheren", "Nervensystems", "darstellen", "und", "zum", "anderen", "ein", "Gap", "-", "junction", "-", "Protein", "bilden", ",", "das", "die", "intra-", "und", "interzellulare", "Kommunikation", "ermoeglicht", ".", "Es", "ist", "nicht", "bekannt", ",", "ueber", "welche", "Zwischenschritte", "die", "einzelnen", "genetischen", "Veraenderungen", "zum", "jeweiligen", "Krankheitsphaenotyp", "fuehren", ".", "Die", "Pathogenese", "ist", "also", "noch", "nicht", "in", "allen", "Einzelheiten", "aufgeklaert", ".", "Die", "molekulargenetischen", "Befunde", "erlauben", "in", "den", "weitaus", "meisten", "Faellen", "eine", "exakte", "Diagnose", "auch", "ohne", "Zuhilfenahme", "histologischer", "Untersuchungen", ".", "Ebenso", "ist", "eine", "praenatale", "Diagnostik", "moeglich", ",", "deren", "Wertigkeit", "wegen", "der", "erheblichen", "Varianz", "der", "spaeteren", "Prognose", "des", "Krankheitsphaenotyps", "jedoch", "gering", "ist", ".", "Durch", "die", "Aufklaerung", "der", "Pathophysiologie", "sind", "neue", "individualtherapeutisch", "einsetzbare", ",", "effektive", "Behandlungsmoeglichkeiten", ",", "zu", "erwarten", "." ]	[ "umlsterm" ]
Collaborative Initial Glaucoma Treatment Study is a Participant_Condition, visual field ( VF ) progression is a Outcome_Physical, 607 subjects with newly diagnosed open - angle glaucoma is a Participant_Condition, treated with either medication or trabeculectomy is a Intervention_Pharmacological, treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye - specific target pressure . Visual field progression was analyzed using repeated measures models is a Intervention_Physical, Visual field progression , measured by Humphrey 24 - 2 full - threshold testing and assessed by the change in the mean deviation ( MD ) is a Outcome_Physical, an indicator of substantial worsening of the VF is a Outcome_Physical, worsening ( > or =3 dB ) of MD is a Outcome_Physical, initial medicine is a Intervention_Pharmacological, VF loss is a Outcome_Physical, Initial surgery is a Intervention_Surgical, VF progression is a Outcome_Physical, subjects with advanced VF loss at baseline is a Participant_Condition, lowering of IOP is a Outcome_Physical, subjects with more advanced VF loss at presentation is a Participant_Condition, patients with diabetes is a Participant_Condition	37991_task0	Sentence: Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article . 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PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article .	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Collaborative Initial Glaucoma Treatment Study is a Participant_Condition, visual field ( VF ) progression is a Outcome_Physical, 607 subjects with newly diagnosed open - angle glaucoma is a Participant_Condition, treated with either medication or trabeculectomy is a Intervention_Pharmacological, treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye - specific target pressure . Visual field progression was analyzed using repeated measures models is a Intervention_Physical, Visual field progression , measured by Humphrey 24 - 2 full - threshold testing and assessed by the change in the mean deviation ( MD ) is a Outcome_Physical, an indicator of substantial worsening of the VF is a Outcome_Physical, worsening ( > or =3 dB ) of MD is a Outcome_Physical, initial medicine is a Intervention_Pharmacological, VF loss is a Outcome_Physical, Initial surgery is a Intervention_Surgical, VF progression is a Outcome_Physical, subjects with advanced VF loss at baseline is a Participant_Condition, lowering of IOP is a Outcome_Physical, subjects with more advanced VF loss at presentation is a Participant_Condition, patients with diabetes is a Participant_Condition	37991_task1	Sentence: Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article . Instructions: please typing these entity words according to sentence: Collaborative Initial Glaucoma Treatment Study, visual field ( VF ) progression, 607 subjects with newly diagnosed open - angle glaucoma, treated with either medication or trabeculectomy, treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye - specific target pressure . 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"O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article .	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Collaborative Initial Glaucoma Treatment Study, visual field ( VF ) progression, 607 subjects with newly diagnosed open - angle glaucoma, treated with either medication or trabeculectomy, treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye - specific target pressure . Visual field progression was analyzed using repeated measures models, Visual field progression , measured by Humphrey 24 - 2 full - threshold testing and assessed by the change in the mean deviation ( MD ), an indicator of substantial worsening of the VF, worsening ( > or =3 dB ) of MD, initial medicine, VF loss, Initial surgery, VF progression, subjects with advanced VF loss at baseline, lowering of IOP, subjects with more advanced VF loss at presentation, patients with diabetes	37991_task2	Sentence: Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article . 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"O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article .	[ "Visual", "field", "progression", "in", "the", "Collaborative", "Initial", "Glaucoma", "Treatment", "Study", "the", "impact", "of", "treatment", "and", "other", "baseline", "factors", ".", "PURPOSE", "To", "evaluate", "factors", "associated", "with", "visual", "field", "(", "VF", ")", "progression", ",", "using", "all", "available", "follow", "-", "up", "through", "9", "years", "after", "treatment", "initiation", ",", "in", "the", "Collaborative", "Initial", "Glaucoma", "Treatment", "Study", "(", "CIGTS", ")", ".", "DESIGN", "Longitudinal", "follow", "-", "up", "of", "participants", "enrolled", "in", "a", "randomized", "clinical", "trial", ".", "PARTICIPANTS", "Six", "hundred", "seven", "newly", "diagnosed", "glaucoma", "patients", ".", "METHODS", "In", "a", "randomized", "clinical", "trial", ",", "607", "subjects", "with", "newly", "diagnosed", "open", "-", "angle", "glaucoma", "initially", "were", "treated", "with", "either", "medication", "or", "trabeculectomy", ".", "After", "treatment", "initiation", "and", "early", "follow", "-", "up", ",", "subjects", "were", "evaluated", "clinically", "at", "6-month", "intervals", ".", "Study", "participants", "in", "both", "arms", "of", "the", "CIGTS", "were", "treated", "aggressively", "in", "an", "effort", "to", "reduce", "intraocular", "pressure", "(", "IOP", ")", "to", "a", "level", "at", "or", "below", "a", "predetermined", ",", "eye", "-", "specific", "target", "pressure", ".", "Visual", "field", "progression", "was", "analyzed", "using", "repeated", "measures", "models", ".", "MAIN", "OUTCOME", "MEASURES", "Visual", "field", "progression", ",", "measured", "by", "Humphrey", "24", "-", "2", "full", "-", "threshold", "testing", "and", "assessed", "by", "the", "change", "in", "the", "mean", "deviation", "(", "MD", ")", ",", "and", "an", "indicator", "of", "substantial", "worsening", "of", "the", "VF", "(", "MD", "decrease", "of", ">", "or", "=3", "dB", "from", "baseline", ")", ",", "assessed", "at", "each", "follow", "-", "up", "visit", ".", "RESULTS", "Follow", "-", "up", "indicated", "minimal", "change", "from", "baseline", "in", "each", "initial", "treatment", "group", "'", "s", "average", "MD", ".", "However", ",", "at", "the", "8-year", "follow", "-", "up", "examination", ",", "substantial", "worsening", "(", ">", "or", "=3", "dB", ")", "of", "MD", "from", "baseline", "was", "found", "in", "21.3", "%", "and", "25.5", "%", "of", "the", "initial", "surgery", "and", "initial", "medicine", "groups", ",", "respectively", ".", "The", "effect", "of", "initial", "treatment", "on", "subsequent", "VF", "loss", "was", "modified", "by", "time", "(", "P", "<", "0.0001", ")", ",", "baseline", "MD", "(", "P", "=", "0.03", ")", ",", "and", "diabetes", "(", "P", "=", "0.01", ")", ".", "Initial", "surgery", "led", "to", "less", "VF", "progression", "than", "initial", "medicine", "in", "subjects", "with", "advanced", "VF", "loss", "at", "baseline", ",", "whereas", "subjects", "with", "diabetes", "had", "more", "VF", "loss", "over", "time", "if", "treated", "initially", "with", "surgery", ".", "CONCLUSIONS", "The", "CIGTS", "intervention", "protocol", "led", "to", "a", "lowering", "of", "IOP", "that", "persisted", "over", "time", "in", "both", "treatment", "groups", ".", "Progression", "in", "VF", "loss", "was", "seen", "in", "a", "subset", ",", "increasing", "to", "more", "than", "20", "%", "of", "the", "subjects", ".", "The", "findings", "regarding", "initial", "surgery", "being", "beneficial", "for", "subjects", "with", "more", "advanced", "VF", "loss", "at", "presentation", ",", "but", "detrimental", "for", "patients", "with", "diabetes", ",", "are", "noteworthy", "and", "warrant", "independent", "confirmation", ".", "FINANCIAL", "DISCLOSURE", "(", "S", ")", "The", "author", "(", "s", ")", "have", "no", "proprietary", "or", "commercial", "interest", "in", "any", "materials", "discussed", "in", "this", "article", "." ]	[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological", "Intervention_Surgical" ]
Tat is a Protein, tat - I is a Protein, Tat - I is a Protein, p49(100 ) is a Protein, p65 is a Protein, Tat - I is a Protein, CAT is a Protein, p105 is a Protein, rel is a Protein, p65 is a Protein, c - rel is a Protein, p49(100 ) is a Protein, p65 is a Protein, tat - I is a Protein	267_task0	Sentence: Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA.	[ "Specific", "NF", "-", "kappa", "B", "subunits", "act", "in", "concert", "with", "Tat", "to", "stimulate", "human", "immunodeficiency", "virus", "type", "1", "transcription", ".", "\n", "NF", "-", "kappa", "B", "is", "a", "protein", "complex", "which", "functions", "in", "concert", "with", "the", "tat", "-", "I", "gene", "product", "to", "stimulate", "human", "immunodeficiency", "virus", "(", "HIV", ")", "transcription", ".", "To", "determine", "whether", "specific", "members", "of", "the", "NF", "-", "kappa", "B", "family", "contribute", "to", "this", "effect", ",", "we", "have", "examined", "the", "abilities", "of", "different", "NF", "-", "kappa", "B", "subunits", "to", "act", "with", "Tat", "-", "I", "to", "stimulate", "transcription", "of", "HIV", "in", "Jurkat", "T", "-", "leukemia", "cells", ".", "We", "have", "found", "that", "the", "p49(100", ")", "DNA", "binding", "subunit", ",", "together", "with", "p65", ",", "can", "act", "in", "concert", "with", "Tat", "-", "I", "to", "stimulate", "the", "expression", "of", "HIV", "-", "CAT", "plasmid", ".", "Little", "effect", "was", "observed", "with", "50-kDa", "forms", "of", "p105", "NF", "-", "kappa", "B", "or", "rel", ",", "in", "combination", "with", "p65", "or", "full", "-", "length", "c", "-", "rel", ",", "which", "do", "not", "stimulate", "the", "HIV", "enhancer", "in", "these", "cells", ".", "These", "findings", "suggest", "that", "the", "combination", "of", "p49(100", ")", "and", "p65", "NF", "-", "kappa", "B", "can", "act", "in", "concert", "with", "the", "tat", "-", "I", "gene", "product", "to", "stimulate", "the", "synthesis", "of", "HIV", "RNA", "." ]	[ "Protein" ]
Tat is a Protein, tat - I is a Protein, Tat - I is a Protein, p49(100 ) is a Protein, p65 is a Protein, Tat - I is a Protein, CAT is a Protein, p105 is a Protein, rel is a Protein, p65 is a Protein, c - rel is a Protein, p49(100 ) is a Protein, p65 is a Protein, tat - I is a Protein	267_task1	Sentence: Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA. Instructions: please typing these entity words according to sentence: Tat, tat - I, Tat - I, p49(100 ), p65, Tat - I, CAT, p105, rel, p65, c - rel, p49(100 ), p65, tat - I Options: Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA.	[ "Specific", "NF", "-", "kappa", "B", "subunits", "act", "in", "concert", "with", "Tat", "to", "stimulate", "human", "immunodeficiency", "virus", "type", "1", "transcription", ".", "\n", "NF", "-", "kappa", "B", "is", "a", "protein", "complex", "which", "functions", "in", "concert", "with", "the", "tat", "-", "I", "gene", "product", "to", "stimulate", "human", "immunodeficiency", "virus", "(", "HIV", ")", "transcription", ".", "To", "determine", "whether", "specific", "members", "of", "the", "NF", "-", "kappa", "B", "family", "contribute", "to", "this", "effect", ",", "we", "have", "examined", "the", "abilities", "of", "different", "NF", "-", "kappa", "B", "subunits", "to", "act", "with", "Tat", "-", "I", "to", "stimulate", "transcription", "of", "HIV", "in", "Jurkat", "T", "-", "leukemia", "cells", ".", "We", "have", "found", "that", "the", "p49(100", ")", "DNA", "binding", "subunit", ",", "together", "with", "p65", ",", "can", "act", "in", "concert", "with", "Tat", "-", "I", "to", "stimulate", "the", "expression", "of", "HIV", "-", "CAT", "plasmid", ".", "Little", "effect", "was", "observed", "with", "50-kDa", "forms", "of", "p105", "NF", "-", "kappa", "B", "or", "rel", ",", "in", "combination", "with", "p65", "or", "full", "-", "length", "c", "-", "rel", ",", "which", "do", "not", "stimulate", "the", "HIV", "enhancer", "in", "these", "cells", ".", "These", "findings", "suggest", "that", "the", "combination", "of", "p49(100", ")", "and", "p65", "NF", "-", "kappa", "B", "can", "act", "in", "concert", "with", "the", "tat", "-", "I", "gene", "product", "to", "stimulate", "the", "synthesis", "of", "HIV", "RNA", "." ]	[ "Protein" ]
Tat, tat - I, Tat - I, p49(100 ), p65, Tat - I, CAT, p105, rel, p65, c - rel, p49(100 ), p65, tat - I	267_task2	Sentence: Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "I-Protein", "I-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA.	[ "Specific", "NF", "-", "kappa", "B", "subunits", "act", "in", "concert", "with", "Tat", "to", "stimulate", "human", "immunodeficiency", "virus", "type", "1", "transcription", ".", "\n", "NF", "-", "kappa", "B", "is", "a", "protein", "complex", "which", "functions", "in", "concert", "with", "the", "tat", "-", "I", "gene", "product", "to", "stimulate", "human", "immunodeficiency", "virus", "(", "HIV", ")", "transcription", ".", "To", "determine", "whether", "specific", "members", "of", "the", "NF", "-", "kappa", "B", "family", "contribute", "to", "this", "effect", ",", "we", "have", "examined", "the", "abilities", "of", "different", "NF", "-", "kappa", "B", "subunits", "to", "act", "with", "Tat", "-", "I", "to", "stimulate", "transcription", "of", "HIV", "in", "Jurkat", "T", "-", "leukemia", "cells", ".", "We", "have", "found", "that", "the", "p49(100", ")", "DNA", "binding", "subunit", ",", "together", "with", "p65", ",", "can", "act", "in", "concert", "with", "Tat", "-", "I", "to", "stimulate", "the", "expression", "of", "HIV", "-", "CAT", "plasmid", ".", "Little", "effect", "was", "observed", "with", "50-kDa", "forms", "of", "p105", "NF", "-", "kappa", "B", "or", "rel", ",", "in", "combination", "with", "p65", "or", "full", "-", "length", "c", "-", "rel", ",", "which", "do", "not", "stimulate", "the", "HIV", "enhancer", "in", "these", "cells", ".", "These", "findings", "suggest", "that", "the", "combination", "of", "p49(100", ")", "and", "p65", "NF", "-", "kappa", "B", "can", "act", "in", "concert", "with", "the", "tat", "-", "I", "gene", "product", "to", "stimulate", "the", "synthesis", "of", "HIV", "RNA", "." ]	[ "Protein" ]
atopic dermatitis is an umlsterm, face is an umlsterm, therapy is an umlsterm, therapeutic is an umlsterm, efficiency is an umlsterm, cold is an umlsterm, light is an umlsterm, treatment is an umlsterm, phototherapy is an umlsterm, patients is an umlsterm, cold is an umlsterm, light is an umlsterm, patients is an umlsterm, patients is an umlsterm, therapy is an umlsterm, treatment protocol is an umlsterm, skin is an umlsterm, patients is an umlsterm, period is an umlsterm, skin is an umlsterm, cold is an umlsterm, light is an umlsterm, patients is an umlsterm, cold is an umlsterm, light is an umlsterm, therapy is an umlsterm, patients is an umlsterm, therapy is an umlsterm, patients is an umlsterm, Plasma is an umlsterm, eosinophil cationic protein is an umlsterm, interleukin-2 is an umlsterm, phototherapy is an umlsterm, therapy is an umlsterm, phototherapy is an umlsterm, cold is an umlsterm, light is an umlsterm, phototherapy is an umlsterm, skin is an umlsterm, blood is an umlsterm, Laser is an umlsterm, sweat is an umlsterm, production is an umlsterm, patient is an umlsterm, visual analog scale is an umlsterm	DerHautarzt.90500027.eng.abstr_task0	Sentence: Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) . 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In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) .	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atopic dermatitis is an umlsterm, face is an umlsterm, therapy is an umlsterm, therapeutic is an umlsterm, efficiency is an umlsterm, cold is an umlsterm, light is an umlsterm, treatment is an umlsterm, phototherapy is an umlsterm, patients is an umlsterm, cold is an umlsterm, light is an umlsterm, patients is an umlsterm, patients is an umlsterm, therapy is an umlsterm, treatment protocol is an umlsterm, skin is an umlsterm, patients is an umlsterm, period is an umlsterm, skin is an umlsterm, cold is an umlsterm, light is an umlsterm, patients is an umlsterm, cold is an umlsterm, light is an umlsterm, therapy is an umlsterm, patients is an umlsterm, therapy is an umlsterm, patients is an umlsterm, Plasma is an umlsterm, eosinophil cationic protein is an umlsterm, interleukin-2 is an umlsterm, phototherapy is an umlsterm, therapy is an umlsterm, phototherapy is an umlsterm, cold is an umlsterm, light is an umlsterm, phototherapy is an umlsterm, skin is an umlsterm, blood is an umlsterm, Laser is an umlsterm, sweat is an umlsterm, production is an umlsterm, patient is an umlsterm, visual analog scale is an umlsterm	DerHautarzt.90500027.eng.abstr_task1	Sentence: Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) . Instructions: please typing these entity words according to sentence: atopic dermatitis, face, therapy, therapeutic, efficiency, cold, light, treatment, phototherapy, patients, cold, light, patients, patients, therapy, treatment protocol, skin, patients, period, skin, cold, light, patients, cold, light, therapy, patients, therapy, patients, Plasma, eosinophil cationic protein, interleukin-2, phototherapy, therapy, phototherapy, cold, light, phototherapy, skin, blood, Laser, sweat, production, patient, visual analog scale Options: umlsterm	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O" ]	Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) .	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atopic dermatitis, face, therapy, therapeutic, efficiency, cold, light, treatment, phototherapy, patients, cold, light, patients, patients, therapy, treatment protocol, skin, patients, period, skin, cold, light, patients, cold, light, therapy, patients, therapy, patients, Plasma, eosinophil cationic protein, interleukin-2, phototherapy, therapy, phototherapy, cold, light, phototherapy, skin, blood, Laser, sweat, production, patient, visual analog scale	DerHautarzt.90500027.eng.abstr_task2	Sentence: Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) . Instructions: please extract entity words from the input sentence	[ "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O" ]	Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) .	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question - asking is a Intervention_Educational, robot intervention is a Intervention_Psychological, human - trainer intervention is a Intervention_Educational, applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA - based intervention conducted by a human trainer is a Intervention_Educational, self - initiated questions is a Outcome_Mental, interventions conducted by a is a Intervention_Psychological, and a is a Intervention_Psychological	59091_task0	Sentence: Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Psychological, Intervention_Educational, Outcome_Mental	[ "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed .	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question - asking is a Intervention_Educational, robot intervention is a Intervention_Psychological, human - trainer intervention is a Intervention_Educational, applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA - based intervention conducted by a human trainer is a Intervention_Educational, self - initiated questions is a Outcome_Mental, interventions conducted by a is a Intervention_Psychological, and a is a Intervention_Psychological	59091_task1	Sentence: Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed . Instructions: please typing these entity words according to sentence: question - asking, robot intervention, human - trainer intervention, applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA - based intervention conducted by a human trainer, self - initiated questions, interventions conducted by a, and a Options: Intervention_Psychological, Intervention_Educational, Outcome_Mental	[ "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed .	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question - asking, robot intervention, human - trainer intervention, applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA - based intervention conducted by a human trainer, self - initiated questions, interventions conducted by a, and a	59091_task2	Sentence: Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed . Instructions: please extract entity words from the input sentence	[ "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "I-Intervention_Educational", "O", "O", "B-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "I-Outcome_Mental", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "I-Intervention_Psychological", "O", "B-Intervention_Psychological", "I-Intervention_Psychological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed .	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Non - Hodgkin - Lymphom is an umlsterm, Lymphom is an umlsterm, Verhalten is an umlsterm, Prognose is an umlsterm, Behandlung is an umlsterm, Lymphomen is an umlsterm, Lymphome is an umlsterm, radiologische is an umlsterm	DerRadiologe.70370035.ger.abstr_task0	Sentence: Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten .	[ "Der", "Gastrointestinaltrakt", "ist", "das", "Organ", ",", "das", "am", "haeufigsten", "von", "einem", "extranodalen", "Non", "-", "Hodgkin", "-", "Lymphom", "befallen", "wird", ".", "Das", "primaere", "gastrointestinale", "Lymphom", "(", "PGIL", ")", "stellt", "ein", "eigenstaendiges", "Krankheitsbild", "dar", ",", "da", "das", "biologische", "Verhalten", ",", "die", "Prognose", "und", "die", "Behandlung", "sich", "von", "den", "nodalen", "Lymphomen", "unterscheiden", ".", "Bildgebende", "Verfahren", "sind", "wichtig", "bei", "der", "Suche", "und", "bei", "der", "Stadieneinteilung", "des", "PGIL", ".", "Die", "gastrointestinalen", "Lymphome", "zeigen", "eine", "Vielfalt", "von", "pathohistologischen", "Erscheinungsbildern", "und", "ein", "weites", "Spektrum", "bei", "der", "Bildgebung", ".", "Die", "Zunahme", "der", "PGIL", "erfordert", "Kenntnisse", "ueber", "das", "klinische", "und", "radiologische", "Bild", "und", "die", "therapeutischen", "Moeglichkeiten", "." ]	[ "umlsterm" ]
Non - Hodgkin - Lymphom is an umlsterm, Lymphom is an umlsterm, Verhalten is an umlsterm, Prognose is an umlsterm, Behandlung is an umlsterm, Lymphomen is an umlsterm, Lymphome is an umlsterm, radiologische is an umlsterm	DerRadiologe.70370035.ger.abstr_task1	Sentence: Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten . Instructions: please typing these entity words according to sentence: Non - Hodgkin - Lymphom, Lymphom, Verhalten, Prognose, Behandlung, Lymphomen, Lymphome, radiologische Options: umlsterm	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten .	[ "Der", "Gastrointestinaltrakt", "ist", "das", "Organ", ",", "das", "am", "haeufigsten", "von", "einem", "extranodalen", "Non", "-", "Hodgkin", "-", "Lymphom", "befallen", "wird", ".", "Das", "primaere", "gastrointestinale", "Lymphom", "(", "PGIL", ")", "stellt", "ein", "eigenstaendiges", "Krankheitsbild", "dar", ",", "da", "das", "biologische", "Verhalten", ",", "die", "Prognose", "und", "die", "Behandlung", "sich", "von", "den", "nodalen", "Lymphomen", "unterscheiden", ".", "Bildgebende", "Verfahren", "sind", "wichtig", "bei", "der", "Suche", "und", "bei", "der", "Stadieneinteilung", "des", "PGIL", ".", "Die", "gastrointestinalen", "Lymphome", "zeigen", "eine", "Vielfalt", "von", "pathohistologischen", "Erscheinungsbildern", "und", "ein", "weites", "Spektrum", "bei", "der", "Bildgebung", ".", "Die", "Zunahme", "der", "PGIL", "erfordert", "Kenntnisse", "ueber", "das", "klinische", "und", "radiologische", "Bild", "und", "die", "therapeutischen", "Moeglichkeiten", "." ]	[ "umlsterm" ]
Non - Hodgkin - Lymphom, Lymphom, Verhalten, Prognose, Behandlung, Lymphomen, Lymphome, radiologische	DerRadiologe.70370035.ger.abstr_task2	Sentence: Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O" ]	Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten .	[ "Der", "Gastrointestinaltrakt", "ist", "das", "Organ", ",", "das", "am", "haeufigsten", "von", "einem", "extranodalen", "Non", "-", "Hodgkin", "-", "Lymphom", "befallen", "wird", ".", "Das", "primaere", "gastrointestinale", "Lymphom", "(", "PGIL", ")", "stellt", "ein", "eigenstaendiges", "Krankheitsbild", "dar", ",", "da", "das", "biologische", "Verhalten", ",", "die", "Prognose", "und", "die", "Behandlung", "sich", "von", "den", "nodalen", "Lymphomen", "unterscheiden", ".", "Bildgebende", "Verfahren", "sind", "wichtig", "bei", "der", "Suche", "und", "bei", "der", "Stadieneinteilung", "des", "PGIL", ".", "Die", "gastrointestinalen", "Lymphome", "zeigen", "eine", "Vielfalt", "von", "pathohistologischen", "Erscheinungsbildern", "und", "ein", "weites", "Spektrum", "bei", "der", "Bildgebung", ".", "Die", "Zunahme", "der", "PGIL", "erfordert", "Kenntnisse", "ueber", "das", "klinische", "und", "radiologische", "Bild", "und", "die", "therapeutischen", "Moeglichkeiten", "." ]	[ "umlsterm" ]
III is a Protein, III is a Protein, lysyl is a Entity, hydroxylysine is a Entity	526_task0	Sentence: Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell.	[ "Regulation", "of", "collagen", "post", "-", "translational", "modification", "in", "transformed", "human", "and", "chick", "-", "embryo", "cells", ".", "\n", "Changes", "in", "the", "regulation", "of", "collagen", "post", "-", "translational", "modification", "in", "transformed", "cells", "were", "studied", "in", "three", "established", "human", "sarcoma", "cell", "lines", "and", "in", "chick", "-", "embryo", "fibroblasts", "freshly", "transformed", "by", "Rous", "sarcoma", "virus", ".", "The", "collagens", "synthesized", "by", "all", "but", "one", "of", "these", "and", "by", "all", "the", "control", "human", "and", "chick", "-", "embryo", "cell", "lines", "were", "almost", "exclusively", "of", "types", "I", "and", "/", "or", "III", ".", "The", "relative", "rate", "of", "collagen", "synthesis", "and", "the", "amounts", "of", "prolyl", "hydroxylase", "activity", "and", "immunoreactive", "protein", "were", "markedly", "low", "in", "all", "the", "transformed", "human", "cell", "lines", ".", "The", "other", "enzymes", "studied", ",", "lysyl", "hydroxylase", ",", "hydroxylysyl", "galactosyltransferase", "and", "galactosylhydroxylysyl", "glucosyltransferase", ",", "never", "showed", "as", "large", "a", "decrease", "in", "activity", "as", "did", "prolyl", "hydroxylase", ",", "suggesting", "a", "more", "efficient", "regulation", "of", "the", "last", "enzyme", "than", "of", "the", "three", "others", ".", "The", "chick", "-", "embryo", "fibroblasts", "freshly", "transformed", "by", "Rous", "sarcoma", "virus", "differed", "from", "the", "human", "sarcoma", "cells", "in", "that", "prolyl", "hydroxylase", "activity", "was", "distinctly", "increased", ",", "whereas", "the", "decreases", "in", "immunoreactive", "prolyl", "hydroxylase", "protein", "and", "the", "three", "other", "enzyme", "activities", "were", "very", "similar", "to", "those", "in", "the", "simian", "-", "virus-40-transformed", "human", "fibroblasts", ".", "It", "seems", "possible", "that", "this", "increased", "prolyl", "hydroxylase", "activity", "is", "only", "a", "temporary", "phenomenon", "occurring", "shortly", "after", "the", "transformation", ",", "and", "may", "be", "followed", "by", "a", "decrease", "in", "activity", "later", ".", "The", "newly", "synthesized", "collagens", "of", "all", "the", "transformed", "cells", "that", "produced", "almost", "exclusively", "collagen", "types", "I", "and", "/", "or", "III", "had", "high", "extents", "of", "lysyl", "hydroxylation", ",", "and", "there", "was", "also", "an", "increase", "in", "the", "ratio", "of", "glycosylated", "to", "non", "-", "glycosylated", "hydroxylysine", ".", "The", "data", "suggest", "that", "one", "critical", "factor", "affecting", "modification", "is", "the", "rate", "of", "collagen", "synthesis", ",", "which", "affects", "the", "ratio", "of", "enzyme", "to", "substrate", "in", "the", "cell", ".", "\n" ]	[ "Entity", "Protein" ]
III is a Protein, III is a Protein, lysyl is a Entity, hydroxylysine is a Entity	526_task1	Sentence: Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell. Instructions: please typing these entity words according to sentence: III, III, lysyl, hydroxylysine Options: Entity, Protein	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell.	[ "Regulation", "of", "collagen", "post", "-", "translational", "modification", "in", "transformed", "human", "and", "chick", "-", "embryo", "cells", ".", "\n", "Changes", "in", "the", "regulation", "of", "collagen", "post", "-", "translational", "modification", "in", "transformed", "cells", "were", "studied", "in", "three", "established", "human", "sarcoma", "cell", "lines", "and", "in", "chick", "-", "embryo", "fibroblasts", "freshly", "transformed", "by", "Rous", "sarcoma", "virus", ".", "The", "collagens", "synthesized", "by", "all", "but", "one", "of", "these", "and", "by", "all", "the", "control", "human", "and", "chick", "-", "embryo", "cell", "lines", "were", "almost", "exclusively", "of", "types", "I", "and", "/", "or", "III", ".", "The", "relative", "rate", "of", "collagen", "synthesis", "and", "the", "amounts", "of", "prolyl", "hydroxylase", "activity", "and", "immunoreactive", "protein", "were", "markedly", "low", "in", "all", "the", "transformed", "human", "cell", "lines", ".", "The", "other", "enzymes", "studied", ",", "lysyl", "hydroxylase", ",", "hydroxylysyl", "galactosyltransferase", "and", "galactosylhydroxylysyl", "glucosyltransferase", ",", "never", "showed", "as", "large", "a", "decrease", "in", "activity", "as", "did", "prolyl", "hydroxylase", ",", "suggesting", "a", "more", "efficient", "regulation", "of", "the", "last", "enzyme", "than", "of", "the", "three", "others", ".", "The", "chick", "-", "embryo", "fibroblasts", "freshly", "transformed", "by", "Rous", "sarcoma", "virus", "differed", "from", "the", "human", "sarcoma", "cells", "in", "that", "prolyl", "hydroxylase", "activity", "was", "distinctly", "increased", ",", "whereas", "the", "decreases", "in", "immunoreactive", "prolyl", "hydroxylase", "protein", "and", "the", "three", "other", "enzyme", "activities", "were", "very", "similar", "to", "those", "in", "the", "simian", "-", "virus-40-transformed", "human", "fibroblasts", ".", "It", "seems", "possible", "that", "this", "increased", "prolyl", "hydroxylase", "activity", "is", "only", "a", "temporary", "phenomenon", "occurring", "shortly", "after", "the", "transformation", ",", "and", "may", "be", "followed", "by", "a", "decrease", "in", "activity", "later", ".", "The", "newly", "synthesized", "collagens", "of", "all", "the", "transformed", "cells", "that", "produced", "almost", "exclusively", "collagen", "types", "I", "and", "/", "or", "III", "had", "high", "extents", "of", "lysyl", "hydroxylation", ",", "and", "there", "was", "also", "an", "increase", "in", "the", "ratio", "of", "glycosylated", "to", "non", "-", "glycosylated", "hydroxylysine", ".", "The", "data", "suggest", "that", "one", "critical", "factor", "affecting", "modification", "is", "the", "rate", "of", "collagen", "synthesis", ",", "which", "affects", "the", "ratio", "of", "enzyme", "to", "substrate", "in", "the", "cell", ".", "\n" ]	[ "Entity", "Protein" ]
III, III, lysyl, hydroxylysine	526_task2	Sentence: Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell. Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Protein", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Entity", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell.	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Ketamin is an umlsterm, intravenoesen Anaesthetika is an umlsterm, Anaesthesie is an umlsterm, Ketamin is an umlsterm, Ketamin is an umlsterm, ligandengesteuerter is an umlsterm, Ionenkanaele is an umlsterm, Rolle is an umlsterm, Analgesie is an umlsterm, Amnesie is an umlsterm, Anaesthesie is an umlsterm, -Opiatrezeptoren is an umlsterm, L - Typ - Kalziumkanaele is an umlsterm, Ionenkanaele is an umlsterm, Rolle is an umlsterm, Ketamin is an umlsterm	DerAnaesthesist.7046s008.ger.abstr_task0	Sentence: Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar .	[ "Das", "Phenzyklidin", "-", "Derivat", "Ketamin", "nimmt", "auch", "30", "Jahre", "nach", "seiner", "klinischen", "Einfuehrung", "eine", "Sonderstellung", "unter", "intravenoesen", "Anaesthetika", "ein", ".", "Seiner", "besonderen", "Wirkung", "wurde", "auch", "mit", "dem", "Begriff", "der", "dissoziativen", "Anaesthesie", "\"", "\"", "Rechnung", "getragen", ",", "deren", "neuropharmakologische", "Grundlage", "jedoch", "nicht", "ausreichend", "geklaert", "ist", ".", "Neue", "methodische", "Moeglichkeiten", "und", "die", "Verfuegbarkeit", "der", "reinen", "Ketaminenantiomere", "haben", "jedoch", "in", "den", "letzten", "Jahren", "Erkenntnisse", "gewinnen", "lassen", ",", "die", "in", "dieser", "Uebersicht", "mit", "ihrer", "Relevanz", "fuer", "die", "analgetische", ",", "anaesthetische", "und", "neuroprotektive", "Wirkung", "von", "Ketamin", "bewertet", "werden", "sollen", ".", "Ketamin", "scheint", "sehr", "spezifisch", "mit", "einer", "kleinen", "Gruppe", "ligandengesteuerter", "Ionenkanaele", "(", "Klasse-1-Rezeptoren", ")", "zu", "interagieren", ",", "wobei", "an", "der", "zentralen", "Rolle", "des", "NMDA", "-", "Rezeptorkanals", "fuer", "Analgesie", ",", "Amnesie", ",", "Anaesthesie", "und", "psychotomimetische", "Wirkungen", "kein", "Zweifel", "besteht", ".", "Zusaetzlich", "tragen", "-Opiatrezeptoren", "monoaminerge", "und", "cholinerge", "Wirkungen", ",", "bei", ".", "Neu", "ist", "die", "klinisch", "bedeutsame", "Interaktion", "mit", "muskarinischen", "Rezeptoren", "und", "non", "-", "NMDA", "-", "Rezeptorkanaelen", ".", "Mit", "Ausnahme", "der", "L", "-", "Typ", "-", "Kalziumkanaele", "spielen", "spannungsgesteuerte", "Ionenkanaele", ",", "soweit", "bisher", "untersucht", ",", "fuer", "klinische", "Wirkungen", "nur", "eine", "untergeordnete", "Rolle", ".", "Die", "Beeinflussung", "von", "L", "-", "Typ", "-", "Kalziumkanaelen", ",", "non", "-", "NMDA", "und", "NMDA", "-", "Rezeptorkanaelen", "sowie", "des", "NO", "-", "cGMP", "-", "Systems", "stellen", "ausserdem", "eine", "rationale", "Basis", "fuer", "die", "neuroprotektive", "Wirksamkeit", "von", "Ketamin", "dar", "." ]	[ "umlsterm" ]
Ketamin is an umlsterm, intravenoesen Anaesthetika is an umlsterm, Anaesthesie is an umlsterm, Ketamin is an umlsterm, Ketamin is an umlsterm, ligandengesteuerter is an umlsterm, Ionenkanaele is an umlsterm, Rolle is an umlsterm, Analgesie is an umlsterm, Amnesie is an umlsterm, Anaesthesie is an umlsterm, -Opiatrezeptoren is an umlsterm, L - Typ - Kalziumkanaele is an umlsterm, Ionenkanaele is an umlsterm, Rolle is an umlsterm, Ketamin is an umlsterm	DerAnaesthesist.7046s008.ger.abstr_task1	Sentence: Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar . Instructions: please typing these entity words according to sentence: Ketamin, intravenoesen Anaesthetika, Anaesthesie, Ketamin, Ketamin, ligandengesteuerter, Ionenkanaele, Rolle, Analgesie, Amnesie, Anaesthesie, -Opiatrezeptoren, L - Typ - Kalziumkanaele, Ionenkanaele, Rolle, Ketamin Options: umlsterm	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar .	[ "Das", "Phenzyklidin", "-", "Derivat", "Ketamin", "nimmt", "auch", "30", "Jahre", "nach", "seiner", "klinischen", "Einfuehrung", "eine", "Sonderstellung", "unter", "intravenoesen", "Anaesthetika", "ein", ".", "Seiner", "besonderen", "Wirkung", "wurde", "auch", "mit", "dem", "Begriff", "der", "dissoziativen", "Anaesthesie", "\"", "\"", "Rechnung", "getragen", ",", "deren", "neuropharmakologische", "Grundlage", "jedoch", "nicht", "ausreichend", "geklaert", "ist", ".", "Neue", "methodische", "Moeglichkeiten", "und", "die", "Verfuegbarkeit", "der", "reinen", "Ketaminenantiomere", "haben", "jedoch", "in", "den", "letzten", "Jahren", "Erkenntnisse", "gewinnen", "lassen", ",", "die", "in", "dieser", "Uebersicht", "mit", "ihrer", "Relevanz", "fuer", "die", "analgetische", ",", "anaesthetische", "und", "neuroprotektive", "Wirkung", "von", "Ketamin", "bewertet", "werden", "sollen", ".", "Ketamin", "scheint", "sehr", "spezifisch", "mit", "einer", "kleinen", "Gruppe", "ligandengesteuerter", "Ionenkanaele", "(", "Klasse-1-Rezeptoren", ")", "zu", "interagieren", ",", "wobei", "an", "der", "zentralen", "Rolle", "des", "NMDA", "-", "Rezeptorkanals", "fuer", "Analgesie", ",", "Amnesie", ",", "Anaesthesie", "und", "psychotomimetische", "Wirkungen", "kein", "Zweifel", "besteht", ".", "Zusaetzlich", "tragen", "-Opiatrezeptoren", "monoaminerge", "und", "cholinerge", "Wirkungen", ",", "bei", ".", "Neu", "ist", "die", "klinisch", "bedeutsame", "Interaktion", "mit", "muskarinischen", "Rezeptoren", "und", "non", "-", "NMDA", "-", "Rezeptorkanaelen", ".", "Mit", "Ausnahme", "der", "L", "-", "Typ", "-", "Kalziumkanaele", "spielen", "spannungsgesteuerte", "Ionenkanaele", ",", "soweit", "bisher", "untersucht", ",", "fuer", "klinische", "Wirkungen", "nur", "eine", "untergeordnete", "Rolle", ".", "Die", "Beeinflussung", "von", "L", "-", "Typ", "-", "Kalziumkanaelen", ",", "non", "-", "NMDA", "und", "NMDA", "-", "Rezeptorkanaelen", "sowie", "des", "NO", "-", "cGMP", "-", "Systems", "stellen", "ausserdem", "eine", "rationale", "Basis", "fuer", "die", "neuroprotektive", "Wirksamkeit", "von", "Ketamin", "dar", "." ]	[ "umlsterm" ]
Ketamin, intravenoesen Anaesthetika, Anaesthesie, Ketamin, Ketamin, ligandengesteuerter, Ionenkanaele, Rolle, Analgesie, Amnesie, Anaesthesie, -Opiatrezeptoren, L - Typ - Kalziumkanaele, Ionenkanaele, Rolle, Ketamin	DerAnaesthesist.7046s008.ger.abstr_task2	Sentence: Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar . Instructions: please extract entity words from the input sentence	[ "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O" ]	Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar .	[ "Das", "Phenzyklidin", "-", "Derivat", "Ketamin", "nimmt", "auch", "30", "Jahre", "nach", "seiner", "klinischen", "Einfuehrung", "eine", "Sonderstellung", "unter", "intravenoesen", "Anaesthetika", "ein", ".", "Seiner", "besonderen", "Wirkung", "wurde", "auch", "mit", "dem", "Begriff", "der", "dissoziativen", "Anaesthesie", "\"", "\"", "Rechnung", "getragen", ",", "deren", "neuropharmakologische", "Grundlage", "jedoch", "nicht", "ausreichend", "geklaert", "ist", ".", "Neue", "methodische", "Moeglichkeiten", "und", "die", "Verfuegbarkeit", "der", "reinen", "Ketaminenantiomere", "haben", "jedoch", "in", "den", "letzten", "Jahren", "Erkenntnisse", "gewinnen", "lassen", ",", "die", "in", "dieser", "Uebersicht", "mit", "ihrer", "Relevanz", "fuer", "die", "analgetische", ",", "anaesthetische", "und", "neuroprotektive", "Wirkung", "von", "Ketamin", "bewertet", "werden", "sollen", ".", "Ketamin", "scheint", "sehr", "spezifisch", "mit", "einer", "kleinen", "Gruppe", "ligandengesteuerter", "Ionenkanaele", "(", "Klasse-1-Rezeptoren", ")", "zu", "interagieren", ",", "wobei", "an", "der", "zentralen", "Rolle", "des", "NMDA", "-", "Rezeptorkanals", "fuer", "Analgesie", ",", "Amnesie", ",", "Anaesthesie", "und", "psychotomimetische", "Wirkungen", "kein", "Zweifel", "besteht", ".", "Zusaetzlich", "tragen", "-Opiatrezeptoren", "monoaminerge", "und", "cholinerge", "Wirkungen", ",", "bei", ".", "Neu", "ist", "die", "klinisch", "bedeutsame", "Interaktion", "mit", "muskarinischen", "Rezeptoren", "und", "non", "-", "NMDA", "-", "Rezeptorkanaelen", ".", "Mit", "Ausnahme", "der", "L", "-", "Typ", "-", "Kalziumkanaele", "spielen", "spannungsgesteuerte", "Ionenkanaele", ",", "soweit", "bisher", "untersucht", ",", "fuer", "klinische", "Wirkungen", "nur", "eine", "untergeordnete", "Rolle", ".", "Die", "Beeinflussung", "von", "L", "-", "Typ", "-", "Kalziumkanaelen", ",", "non", "-", "NMDA", "und", "NMDA", "-", "Rezeptorkanaelen", "sowie", "des", "NO", "-", "cGMP", "-", "Systems", "stellen", "ausserdem", "eine", "rationale", "Basis", "fuer", "die", "neuroprotektive", "Wirksamkeit", "von", "Ketamin", "dar", "." ]	[ "umlsterm" ]
lectins is a protein, ammonium sulphate is a compound	DS.d981_task0	Sentence: The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein	[ "O", "B-protein", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin.	[ "The", "lectins", "were", "isolated", "by", "ammonium", "sulphate", "treatment", "of", "crude", "extracts", "followed", "by", "chromatography", "on", "chitin", "." ]	[ "compound", "protein" ]
lectins is a protein, ammonium sulphate is a compound	DS.d981_task1	Sentence: The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin. Instructions: please typing these entity words according to sentence: lectins, ammonium sulphate Options: compound, protein	[ "O", "B-protein", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin.	[ "The", "lectins", "were", "isolated", "by", "ammonium", "sulphate", "treatment", "of", "crude", "extracts", "followed", "by", "chromatography", "on", "chitin", "." ]	[ "compound", "protein" ]
lectins, ammonium sulphate	DS.d981_task2	Sentence: The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin. Instructions: please extract entity words from the input sentence	[ "O", "B-protein", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin.	[ "The", "lectins", "were", "isolated", "by", "ammonium", "sulphate", "treatment", "of", "crude", "extracts", "followed", "by", "chromatography", "on", "chitin", "." ]	[ "compound", "protein" ]
malignant is an umlsterm, tumors is an umlsterm, carcinosarcomas is an umlsterm, neoplasm is an umlsterm, probability is an umlsterm, uterus is an umlsterm, old is an umlsterm, female is an umlsterm, patient is an umlsterm, Histopathological is an umlsterm, evaluation is an umlsterm, biopsy is an umlsterm, malignancy is an umlsterm, time is an umlsterm, enlargement is an umlsterm, histopathological is an umlsterm, evaluation is an umlsterm, malignant is an umlsterm, tumor is an umlsterm, carcinosarcoma is an umlsterm, patient is an umlsterm, radiation is an umlsterm, disease is an umlsterm	DerUrologeA.80370382.eng.abstr_task0	Sentence: In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease .	[ "In", "total", "malignant", "mixed", "tumors", "(", "carcinosarcomas", ")", "represent", "a", "very", "rare", "gynecological", "neoplasm", ".", "In", "accordance", "with", "the", "embryological", "genesis", "primary", "localizations", "are", "with", "descending", "probability", "the", "uterus", ",", "the", "ovarians", "and", "finally", "the", "tubes", ".", "We", "report", "on", "a", "55", "year", "old", "female", "patient", ",", "with", "a", "paraurethral", "mass", ",", "which", "was", "primarily", "diagnosed", "in", "1994", ".", "Histopathological", "evaluation", "of", "a", "transvaginal", "biopsy", "did", "not", "demonstrate", "evidence", "of", "malignancy", "at", "that", "time", ".", "After", "painful", "enlargement", "the", "paraurethral", "mass", "was", "resected", "surgically", "and", "histopathological", "evaluation", "revealed", "a", "primary", "paraurethral", "malignant", "mixed", "tumor", "(", "carcinosarcoma", ")", ".", "Postoperatively", ",", "the", "patient", "underwent", "percutaneous", "(", "46,4", "Gy", ")", "and", "intracavitarv", "(", "2", "x", "6", "Gy", ")", "radiation", ".", "Twelve", "months", "postoperatively", "there", "is", "no", "evidence", "of", "disease", "." ]	[ "umlsterm" ]
malignant is an umlsterm, tumors is an umlsterm, carcinosarcomas is an umlsterm, neoplasm is an umlsterm, probability is an umlsterm, uterus is an umlsterm, old is an umlsterm, female is an umlsterm, patient is an umlsterm, Histopathological is an umlsterm, evaluation is an umlsterm, biopsy is an umlsterm, malignancy is an umlsterm, time is an umlsterm, enlargement is an umlsterm, histopathological is an umlsterm, evaluation is an umlsterm, malignant is an umlsterm, tumor is an umlsterm, carcinosarcoma is an umlsterm, patient is an umlsterm, radiation is an umlsterm, disease is an umlsterm	DerUrologeA.80370382.eng.abstr_task1	Sentence: In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease . Instructions: please typing these entity words according to sentence: malignant, tumors, carcinosarcomas, neoplasm, probability, uterus, old, female, patient, Histopathological, evaluation, biopsy, malignancy, time, enlargement, histopathological, evaluation, malignant, tumor, carcinosarcoma, patient, radiation, disease Options: umlsterm	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease .	[ "In", "total", "malignant", "mixed", "tumors", "(", "carcinosarcomas", ")", "represent", "a", "very", "rare", "gynecological", "neoplasm", ".", "In", "accordance", "with", "the", "embryological", "genesis", "primary", "localizations", "are", "with", "descending", "probability", "the", "uterus", ",", "the", "ovarians", "and", "finally", "the", "tubes", ".", "We", "report", "on", "a", "55", "year", "old", "female", "patient", ",", "with", "a", "paraurethral", "mass", ",", "which", "was", "primarily", "diagnosed", "in", "1994", ".", "Histopathological", "evaluation", "of", "a", "transvaginal", "biopsy", "did", "not", "demonstrate", "evidence", "of", "malignancy", "at", "that", "time", ".", "After", "painful", "enlargement", "the", "paraurethral", "mass", "was", "resected", "surgically", "and", "histopathological", "evaluation", "revealed", "a", "primary", "paraurethral", "malignant", "mixed", "tumor", "(", "carcinosarcoma", ")", ".", "Postoperatively", ",", "the", "patient", "underwent", "percutaneous", "(", "46,4", "Gy", ")", "and", "intracavitarv", "(", "2", "x", "6", "Gy", ")", "radiation", ".", "Twelve", "months", "postoperatively", "there", "is", "no", "evidence", "of", "disease", "." ]	[ "umlsterm" ]
malignant, tumors, carcinosarcomas, neoplasm, probability, uterus, old, female, patient, Histopathological, evaluation, biopsy, malignancy, time, enlargement, histopathological, evaluation, malignant, tumor, carcinosarcoma, patient, radiation, disease	DerUrologeA.80370382.eng.abstr_task2	Sentence: In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease . Instructions: please extract entity words from the input sentence	[ "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O" ]	In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease .	[ "In", "total", "malignant", "mixed", "tumors", "(", "carcinosarcomas", ")", "represent", "a", "very", "rare", "gynecological", "neoplasm", ".", "In", "accordance", "with", "the", "embryological", "genesis", "primary", "localizations", "are", "with", "descending", "probability", "the", "uterus", ",", "the", "ovarians", "and", "finally", "the", "tubes", ".", "We", "report", "on", "a", "55", "year", "old", "female", "patient", ",", "with", "a", "paraurethral", "mass", ",", "which", "was", "primarily", "diagnosed", "in", "1994", ".", "Histopathological", "evaluation", "of", "a", "transvaginal", "biopsy", "did", "not", "demonstrate", "evidence", "of", "malignancy", "at", "that", "time", ".", "After", "painful", "enlargement", "the", "paraurethral", "mass", "was", "resected", "surgically", "and", "histopathological", "evaluation", "revealed", "a", "primary", "paraurethral", "malignant", "mixed", "tumor", "(", "carcinosarcoma", ")", ".", "Postoperatively", ",", "the", "patient", "underwent", "percutaneous", "(", "46,4", "Gy", ")", "and", "intracavitarv", "(", "2", "x", "6", "Gy", ")", "radiation", ".", "Twelve", "months", "postoperatively", "there", "is", "no", "evidence", "of", "disease", "." ]	[ "umlsterm" ]
migraine is a Outcome_Mental, flunarizine is a Intervention_Pharmacological, acetylsalicylic acid is a Intervention_Pharmacological, 30 is a Participant_Sample-size, children between 7 and 17 is a Participant_Age, common or classical migraine is a Participant_Condition, blocker Flunarizine ( Sibelium ) is a Intervention_Pharmacological, Acetylsalicylic acid ( ASS ) is a Intervention_Pharmacological, attack frequency and duration is a Outcome_Physical, reduction of attack frequency or symptoms is a Outcome_Physical, Migraine frequency is a Outcome_Other, Duration is a Outcome_Other, slight body weight gain is a Outcome_Adverse-effects, abdominal pain is a Outcome_Adverse-effects, childhood migraine . is a Participant_Condition	75521_task0	Sentence: [ Prevention of migraine with flunarizine and acetylsalicylic acid . A double-blind study ] . UNLABELLED 30 children between 7 and 17 years suffering from at least 2 attacks/month of common or classical migraine since more than 1 year were studied . After clinical exclusion of symptomatic headache 4 weeks were documented by means of a migraine diary . Prophylaxis with Calcium entry blocker Flunarizine ( Sibelium ) or Thromboxane A inhibitor Acetylsalicylic acid ( ASS ) was carried out in a double blind design for 3 months . Medication was given as one dosage in the evening : 2-5 mg/kg KG ASS or 5-10 mg Flunarizine . Documented attack frequency and duration were controlled at monthly physical examinations . Final results showed no differences in significant reduction of attack frequency or symptoms between both different therapeutic principals . 72.4 % ( ASS 73.3 % ; Flunarizine 71.4 % ) of patients were attack-free or had at least a 50 % reduction . Migraine frequency of initially 7-8 was reduced to 1-2 attacks/month . Duration remained constant in both groups ( 1-3 h ) . Side effects were slight body weight gain or abdominal pain after intake , prophylaxis had not to be interrupted therefore . Longtime prognosis is not yet possible because the time of observation is too short so far . CONCLUSION Both substances are definitely useful and have few side effects in childhood migraine . If the response to one is insufficient the other substance should be tried . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Condition, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental	[ "O", "O", "O", "B-Outcome_Mental", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	[ Prevention of migraine with flunarizine and acetylsalicylic acid . A double-blind study ] . UNLABELLED 30 children between 7 and 17 years suffering from at least 2 attacks/month of common or classical migraine since more than 1 year were studied . After clinical exclusion of symptomatic headache 4 weeks were documented by means of a migraine diary . Prophylaxis with Calcium entry blocker Flunarizine ( Sibelium ) or Thromboxane A inhibitor Acetylsalicylic acid ( ASS ) was carried out in a double blind design for 3 months . Medication was given as one dosage in the evening : 2-5 mg/kg KG ASS or 5-10 mg Flunarizine . Documented attack frequency and duration were controlled at monthly physical examinations . Final results showed no differences in significant reduction of attack frequency or symptoms between both different therapeutic principals . 72.4 % ( ASS 73.3 % ; Flunarizine 71.4 % ) of patients were attack-free or had at least a 50 % reduction . Migraine frequency of initially 7-8 was reduced to 1-2 attacks/month . Duration remained constant in both groups ( 1-3 h ) . Side effects were slight body weight gain or abdominal pain after intake , prophylaxis had not to be interrupted therefore . Longtime prognosis is not yet possible because the time of observation is too short so far . CONCLUSION Both substances are definitely useful and have few side effects in childhood migraine . If the response to one is insufficient the other substance should be tried .	[ "[", "Prevention", "of", "migraine", "with", "flunarizine", "and", "acetylsalicylic", "acid", ".", "A", "double", "-", "blind", "study", "]", ".", "UNLABELLED", "30", "children", "between", "7", "and", "17", "years", "suffering", "from", "at", "least", "2", "attacks", "/", "month", "of", "common", "or", "classical", "migraine", "since", "more", "than", "1", "year", "were", "studied", ".", "After", "clinical", "exclusion", "of", "symptomatic", "headache", "4", "weeks", "were", "documented", "by", "means", "of", "a", "migraine", "diary", ".", "Prophylaxis", "with", "Calcium", "entry", "blocker", "Flunarizine", "(", "Sibelium", ")", "or", "Thromboxane", "A", "inhibitor", "Acetylsalicylic", "acid", "(", "ASS", ")", "was", "carried", "out", "in", "a", "double", "blind", "design", "for", "3", "months", ".", "Medication", "was", "given", "as", "one", "dosage", "in", "the", "evening", ":", "2", "-", "5", "mg", "/", "kg", "KG", "ASS", "or", "5", "-", "10", "mg", "Flunarizine", ".", "Documented", "attack", "frequency", "and", "duration", "were", "controlled", "at", "monthly", "physical", "examinations", ".", "Final", "results", "showed", "no", "differences", "in", "significant", "reduction", "of", "attack", "frequency", "or", "symptoms", "between", "both", "different", "therapeutic", "principals", ".", "72.4", "%", "(", "ASS", "73.3", "%", ";", "Flunarizine", "71.4", "%", ")", "of", "patients", "were", "attack", "-", "free", "or", "had", "at", "least", "a", "50", "%", "reduction", ".", "Migraine", "frequency", "of", "initially", "7", "-", "8", "was", "reduced", "to", "1", "-", "2", "attacks", "/", "month", ".", "Duration", "remained", "constant", "in", "both", "groups", "(", "1", "-", "3", "h", ")", ".", "Side", "effects", "were", "slight", "body", "weight", "gain", "or", "abdominal", "pain", "after", "intake", ",", "prophylaxis", "had", "not", "to", "be", "interrupted", "therefore", ".", "Longtime", "prognosis", "is", "not", "yet", "possible", "because", "the", "time", "of", "observation", "is", "too", "short", "so", "far", ".", "CONCLUSION", "Both", "substances", "are", "definitely", "useful", "and", "have", "few", "side", "effects", "in", "childhood", "migraine", ".", "If", "the", "response", "to", "one", "is", "insufficient", "the", "other", "substance", "should", "be", "tried", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition", "Participant_Age", "Outcome_Adverse-effects", "Outcome_Other", "Outcome_Mental", "Participant_Sample-size" ]
migraine is a Outcome_Mental, flunarizine is a Intervention_Pharmacological, acetylsalicylic acid is a Intervention_Pharmacological, 30 is a Participant_Sample-size, children between 7 and 17 is a Participant_Age, common or classical migraine is a Participant_Condition, blocker Flunarizine ( Sibelium ) is a Intervention_Pharmacological, Acetylsalicylic acid ( ASS ) is a Intervention_Pharmacological, attack frequency and duration is a Outcome_Physical, reduction of attack frequency or symptoms is a Outcome_Physical, Migraine frequency is a Outcome_Other, Duration is a Outcome_Other, slight body weight gain is a Outcome_Adverse-effects, abdominal pain is a Outcome_Adverse-effects, childhood migraine . is a Participant_Condition	75521_task1	Sentence: [ Prevention of migraine with flunarizine and acetylsalicylic acid . A double-blind study ] . UNLABELLED 30 children between 7 and 17 years suffering from at least 2 attacks/month of common or classical migraine since more than 1 year were studied . After clinical exclusion of symptomatic headache 4 weeks were documented by means of a migraine diary . Prophylaxis with Calcium entry blocker Flunarizine ( Sibelium ) or Thromboxane A inhibitor Acetylsalicylic acid ( ASS ) was carried out in a double blind design for 3 months . Medication was given as one dosage in the evening : 2-5 mg/kg KG ASS or 5-10 mg Flunarizine . Documented attack frequency and duration were controlled at monthly physical examinations . Final results showed no differences in significant reduction of attack frequency or symptoms between both different therapeutic principals . 72.4 % ( ASS 73.3 % ; Flunarizine 71.4 % ) of patients were attack-free or had at least a 50 % reduction . Migraine frequency of initially 7-8 was reduced to 1-2 attacks/month . Duration remained constant in both groups ( 1-3 h ) . Side effects were slight body weight gain or abdominal pain after intake , prophylaxis had not to be interrupted therefore . Longtime prognosis is not yet possible because the time of observation is too short so far . CONCLUSION Both substances are definitely useful and have few side effects in childhood migraine . If the response to one is insufficient the other substance should be tried . Instructions: please typing these entity words according to sentence: migraine, flunarizine, acetylsalicylic acid, 30, children between 7 and 17, common or classical migraine, blocker Flunarizine ( Sibelium ), Acetylsalicylic acid ( ASS ), attack frequency and duration, reduction of attack frequency or symptoms, Migraine frequency, Duration, slight body weight gain, abdominal pain, childhood migraine . Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Condition, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental	[ "O", "O", "O", "B-Outcome_Mental", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]	[ Prevention of migraine with flunarizine and acetylsalicylic acid . A double-blind study ] . UNLABELLED 30 children between 7 and 17 years suffering from at least 2 attacks/month of common or classical migraine since more than 1 year were studied . After clinical exclusion of symptomatic headache 4 weeks were documented by means of a migraine diary . Prophylaxis with Calcium entry blocker Flunarizine ( Sibelium ) or Thromboxane A inhibitor Acetylsalicylic acid ( ASS ) was carried out in a double blind design for 3 months . Medication was given as one dosage in the evening : 2-5 mg/kg KG ASS or 5-10 mg Flunarizine . Documented attack frequency and duration were controlled at monthly physical examinations . Final results showed no differences in significant reduction of attack frequency or symptoms between both different therapeutic principals . 72.4 % ( ASS 73.3 % ; Flunarizine 71.4 % ) of patients were attack-free or had at least a 50 % reduction . Migraine frequency of initially 7-8 was reduced to 1-2 attacks/month . Duration remained constant in both groups ( 1-3 h ) . Side effects were slight body weight gain or abdominal pain after intake , prophylaxis had not to be interrupted therefore . Longtime prognosis is not yet possible because the time of observation is too short so far . CONCLUSION Both substances are definitely useful and have few side effects in childhood migraine . If the response to one is insufficient the other substance should be tried .	[ "[", "Prevention", "of", "migraine", "with", "flunarizine", "and", "acetylsalicylic", "acid", ".", "A", "double", "-", "blind", "study", "]", ".", "UNLABELLED", "30", "children", "between", "7", "and", "17", "years", "suffering", "from", "at", "least", "2", "attacks", "/", "month", "of", "common", "or", "classical", "migraine", "since", "more", "than", "1", "year", "were", "studied", ".", "After", "clinical", "exclusion", "of", "symptomatic", "headache", "4", "weeks", "were", "documented", "by", "means", "of", "a", "migraine", "diary", ".", "Prophylaxis", "with", "Calcium", "entry", "blocker", "Flunarizine", "(", "Sibelium", ")", "or", "Thromboxane", "A", "inhibitor", "Acetylsalicylic", "acid", "(", "ASS", ")", "was", "carried", "out", "in", "a", "double", "blind", "design", "for", "3", "months", ".", "Medication", "was", "given", "as", "one", "dosage", "in", "the", "evening", ":", "2", "-", "5", "mg", "/", "kg", "KG", "ASS", "or", "5", "-", "10", "mg", "Flunarizine", ".", "Documented", "attack", "frequency", "and", "duration", "were", "controlled", "at", "monthly", "physical", "examinations", ".", "Final", "results", "showed", "no", "differences", "in", "significant", "reduction", "of", "attack", "frequency", "or", "symptoms", "between", "both", "different", "therapeutic", "principals", ".", "72.4", "%", "(", "ASS", "73.3", "%", ";", "Flunarizine", "71.4", "%", ")", "of", "patients", "were", "attack", "-", "free", "or", "had", "at", "least", "a", "50", "%", "reduction", ".", "Migraine", "frequency", "of", "initially", "7", "-", "8", "was", "reduced", "to", "1", "-", "2", "attacks", "/", "month", ".", "Duration", "remained", "constant", "in", "both", "groups", "(", "1", "-", "3", "h", ")", ".", "Side", "effects", "were", "slight", "body", "weight", "gain", "or", "abdominal", "pain", "after", "intake", ",", "prophylaxis", "had", "not", "to", "be", "interrupted", "therefore", ".", "Longtime", "prognosis", "is", "not", "yet", "possible", "because", "the", "time", "of", "observation", "is", "too", "short", "so", "far", ".", "CONCLUSION", "Both", "substances", "are", "definitely", "useful", "and", "have", "few", "side", "effects", "in", "childhood", "migraine", ".", "If", "the", "response", "to", "one", "is", "insufficient", "the", "other", "substance", "should", "be", "tried", "." ]	[ "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition", "Participant_Age", "Outcome_Adverse-effects", "Outcome_Other", "Outcome_Mental", "Participant_Sample-size" ]

Individuals with ASD is a participant, metaphor is an intervention

490_task1

Sentence: Individuals with ASD performed at greater than chance levels on both metaphor types , although their performance was lower than TD participants . Instructions: please typing these entity words according to sentence: Individuals with ASD, metaphor Options: intervention, participant

[ "B-participant", "I-participant", "I-participant", "O", "O", "O", "O", "O", "O", "O", "O", "B-intervention", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Individuals with ASD performed at greater than chance levels on both metaphor types , although their performance was lower than TD participants .

[ "Individuals", "with", "ASD", "performed", "at", "greater", "than", "chance", "levels", "on", "both", "metaphor", "types", ",", "although", "their", "performance", "was", "lower", "than", "TD", "participants", "." ]

[ "participant", "intervention", "outcome" ]

Individuals with ASD, metaphor

490_task2

Sentence: Individuals with ASD performed at greater than chance levels on both metaphor types , although their performance was lower than TD participants . Instructions: please extract entity words from the input sentence

[ "B-participant", "I-participant", "I-participant", "O", "O", "O", "O", "O", "O", "O", "O", "B-intervention", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Individuals with ASD performed at greater than chance levels on both metaphor types , although their performance was lower than TD participants .

[ "Individuals", "with", "ASD", "performed", "at", "greater", "than", "chance", "levels", "on", "both", "metaphor", "types", ",", "although", "their", "performance", "was", "lower", "than", "TD", "participants", "." ]

[ "participant", "intervention", "outcome" ]

Internal mammary artery is an umlsterm, grafts is an umlsterm, blood supply is an umlsterm, myocardium is an umlsterm, myocardial ischemia is an umlsterm, surgical is an umlsterm, method is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm, measurement is an umlsterm, heart is an umlsterm, reperfusion is an umlsterm, cardioplegia is an umlsterm, patients is an umlsterm, multi - vessel is an umlsterm, coronary artery disease is an umlsterm, coronary artery bypass is an umlsterm, grafting is an umlsterm, graft is an umlsterm, anterior is an umlsterm, artery is an umlsterm, saphenous vein is an umlsterm, grafts is an umlsterm, arteries is an umlsterm, cold is an umlsterm, aorta is an umlsterm, graft is an umlsterm, temperatures is an umlsterm, reperfusion is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm, rewarming is an umlsterm, speed is an umlsterm, derivative is an umlsterm, temperature is an umlsterm, time is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm

ZfuerHerzThoraxGefaesschirurgie.00140070.eng.abstr_task0

Sentence: Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses .

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[ "umlsterm" ]

Internal mammary artery is an umlsterm, grafts is an umlsterm, blood supply is an umlsterm, myocardium is an umlsterm, myocardial ischemia is an umlsterm, surgical is an umlsterm, method is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm, measurement is an umlsterm, heart is an umlsterm, reperfusion is an umlsterm, cardioplegia is an umlsterm, patients is an umlsterm, multi - vessel is an umlsterm, coronary artery disease is an umlsterm, coronary artery bypass is an umlsterm, grafting is an umlsterm, graft is an umlsterm, anterior is an umlsterm, artery is an umlsterm, saphenous vein is an umlsterm, grafts is an umlsterm, arteries is an umlsterm, cold is an umlsterm, aorta is an umlsterm, graft is an umlsterm, temperatures is an umlsterm, reperfusion is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm, rewarming is an umlsterm, speed is an umlsterm, derivative is an umlsterm, temperature is an umlsterm, time is an umlsterm, graft is an umlsterm, function is an umlsterm, temperature is an umlsterm

ZfuerHerzThoraxGefaesschirurgie.00140070.eng.abstr_task1

Sentence: Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses . Instructions: please typing these entity words according to sentence: Internal mammary artery, grafts, blood supply, myocardium, myocardial ischemia, surgical, method, graft, function, temperature, measurement, heart, reperfusion, cardioplegia, patients, multi - vessel, coronary artery disease, coronary artery bypass, grafting, graft, anterior, artery, saphenous vein, grafts, arteries, cold, aorta, graft, temperatures, reperfusion, graft, function, temperature, rewarming, speed, derivative, temperature, time, graft, function, temperature Options: umlsterm

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Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses .

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[ "umlsterm" ]

Internal mammary artery, grafts, blood supply, myocardium, myocardial ischemia, surgical, method, graft, function, temperature, measurement, heart, reperfusion, cardioplegia, patients, multi - vessel, coronary artery disease, coronary artery bypass, grafting, graft, anterior, artery, saphenous vein, grafts, arteries, cold, aorta, graft, temperatures, reperfusion, graft, function, temperature, rewarming, speed, derivative, temperature, time, graft, function, temperature

ZfuerHerzThoraxGefaesschirurgie.00140070.eng.abstr_task2

Sentence: Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses . Instructions: please extract entity words from the input sentence

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Internal mammary artery ( IMA ) bypass grafts have a satisfactorily long lasting blood supply to the myocardium . Their initial flow capacity can be insufficient with subsequent regional myocardial ischemia . This study represents a feasable surgical method to evaluate the effectiveness of the IMA graft function by temperature measurement of the heart during warm reperfusion after hypothermic cardioplegia . Twenty-five patients with multi-vessel coronary artery disease underwent coronary artery bypass grafting using the IMA as an arterial graft to the left anterior descending coronary artery and saphenous vein grafts to the remaining coronary arteries . Distal anastomoses were installed during cold intermittent blood-cardioplegic arrest . After unclamping the aorta and IMA graft , the temperatures in cardiac front and rear sides were measured during the first five minutes of warm reperfusion . A sufficient IMA graft function was expressed by a typical rise of temperature : The cardiac front and rear sides showed a parabolic and exponential course , respectively . The rewarming speed expressed as the first derivative of temperature over time led to a sharp and early peak for the front side , and a smaller and delayed peak for the rear side . An insufficient IMA graft function could be recognized by atypical temperature courses .

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[ "umlsterm" ]

exercise is a Intervention_Physical, bone health is a Outcome_Physical, Exercise is a Intervention_Physical, bone strength is a Outcome_Physical, Brief , high - impact exercise is a Intervention_Physical, femoral neck bone density is a Outcome_Physical, femoral neck BMD is a Outcome_Physical, whether BMD change differed between hip sites is a Outcome_Physical, premenopausal women is a Participant_Condition, exercise intervention is a Intervention_Physical, bone changes is a Outcome_Physical, Peak ground reaction forces is a Outcome_Physical, change in femoral neck BMD is a Outcome_Physical, BMD changes at upper neck , lower neck and trochanter is a Outcome_Physical, exercises is a Intervention_Physical, Brief high - impact exercise is a Intervention_Physical, hip fragility is a Outcome_Physical

43331_task0

Sentence: Optimum frequency of exercise for bone health : randomised controlled trial of a high-impact unilateral intervention . INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Physical, Outcome_Physical, Participant_Condition

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Optimum frequency of exercise for bone health : randomised controlled trial of a high-impact unilateral intervention . INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response .

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[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition" ]

exercise is a Intervention_Physical, bone health is a Outcome_Physical, Exercise is a Intervention_Physical, bone strength is a Outcome_Physical, Brief , high - impact exercise is a Intervention_Physical, femoral neck bone density is a Outcome_Physical, femoral neck BMD is a Outcome_Physical, whether BMD change differed between hip sites is a Outcome_Physical, premenopausal women is a Participant_Condition, exercise intervention is a Intervention_Physical, bone changes is a Outcome_Physical, Peak ground reaction forces is a Outcome_Physical, change in femoral neck BMD is a Outcome_Physical, BMD changes at upper neck , lower neck and trochanter is a Outcome_Physical, exercises is a Intervention_Physical, Brief high - impact exercise is a Intervention_Physical, hip fragility is a Outcome_Physical

43331_task1

Sentence: Optimum frequency of exercise for bone health : randomised controlled trial of a high-impact unilateral intervention . INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response . Instructions: please typing these entity words according to sentence: exercise, bone health, Exercise, bone strength, Brief , high - impact exercise, femoral neck bone density, femoral neck BMD, whether BMD change differed between hip sites, premenopausal women, exercise intervention, bone changes, Peak ground reaction forces, change in femoral neck BMD, BMD changes at upper neck , lower neck and trochanter, exercises, Brief high - impact exercise, hip fragility Options: Intervention_Physical, Outcome_Physical, Participant_Condition

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Optimum frequency of exercise for bone health : randomised controlled trial of a high-impact unilateral intervention . INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response .

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[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition" ]

exercise, bone health, Exercise, bone strength, Brief , high - impact exercise, femoral neck bone density, femoral neck BMD, whether BMD change differed between hip sites, premenopausal women, exercise intervention, bone changes, Peak ground reaction forces, change in femoral neck BMD, BMD changes at upper neck , lower neck and trochanter, exercises, Brief high - impact exercise, hip fragility

43331_task2

Sentence: Optimum frequency of exercise for bone health : randomised controlled trial of a high-impact unilateral intervention . INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response . Instructions: please extract entity words from the input sentence

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Optimum frequency of exercise for bone health : randomised controlled trial of a high-impact unilateral intervention . INTRODUCTION Exercise can increase bone strength , but to be effective in reducing fracture risk , exercise must be feasible enough to be adopted into daily life and influence potentially vulnerable skeletal sites such as the superolateral cortex of the femoral neck , where thinning is associated with increased fracture risk . Brief , high-impact exercise increases femoral neck bone density but the optimal frequency of such exercise and the location of bone accrual is unknown . This study thus examined ( 1 ) the effectiveness of different weekly frequencies of exercise on femoral neck BMD and ( 2 ) whether BMD change differed between hip sites using a high-impact , unilateral intervention . METHODS Healthy premenopausal women were randomly assigned to exercise 0 , 2 , 4 , or 7 days/week for 6 months . The exercise intervention incorporated 50 multidirectional hops on one randomly selected leg . BMD was measured by DXA at baseline and after 6 months of exercise . Changes in the exercise leg were compared between groups using ANCOVA , with change in the control leg and baseline BMD as covariates . RM-MANOVA was conducted to determine whether bone changes from exercise differed between hip sites . RESULTS 61 women ( age 33.6+/-11.1 years ) completed the intervention . Compliance amongst exercisers was 86.7+/-10.6 % . Peak ground reaction forces during exercise increased from 2.5 to 2.8 times body weight . The change in femoral neck BMD in the exercise limb ( adjusted for change in the control limb and baseline BMD ) differed between groups ( p=0.015 ) , being -0.3 % ( -1.2 to 0.6 ) , 0.0 % ( -1.0 to 1.0 ) , 0.9 % ( -0.1 to 2.0 ) and 1.8 % ( 0.8 to 2.8 ) in those exercising 0 , 2 , 4 and 7 days per week , respectively . When BMD changes at upper neck , lower neck and trochanter were compared using RM-MANOVA , a significant exercise effect was observed ( p=0.048 ) , but this did not differ significantly between sites ( p=0.439 ) despite greatest mean increases at the upper femoral neck . CONCLUSIONS Brief , daily hopping exercises increased femoral neck BMD in premenopausal women but less frequent exercise was not effective . Brief high-impact exercise may have a role in reducing hip fragility , but may need to be performed frequently for optimal response .

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[ "Outcome_Physical", "Intervention_Physical", "Participant_Condition" ]

prospective study is an umlsterm, patients is an umlsterm, myocardial infarction is an umlsterm, risk is an umlsterm, sudden cardiac death is an umlsterm, patients is an umlsterm, follow - up - period is an umlsterm

ZfuerKardiologie.70860883.eng.abstr_task0

Sentence: A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period .

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[ "umlsterm" ]

prospective study is an umlsterm, patients is an umlsterm, myocardial infarction is an umlsterm, risk is an umlsterm, sudden cardiac death is an umlsterm, patients is an umlsterm, follow - up - period is an umlsterm

ZfuerKardiologie.70860883.eng.abstr_task1

Sentence: A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period . Instructions: please typing these entity words according to sentence: prospective study, patients, myocardial infarction, risk, sudden cardiac death, patients, follow - up - period Options: umlsterm

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A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period .

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[ "umlsterm" ]

prospective study, patients, myocardial infarction, risk, sudden cardiac death, patients, follow - up - period

ZfuerKardiologie.70860883.eng.abstr_task2

Sentence: A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period . Instructions: please extract entity words from the input sentence

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A prospective study was performed of the correlation of ventricular late potentials ( LP ) and clinical parameters in patients after acute myocardial infarction . To evaluate the prognostic significance of the signalaveraged-electrocardiogram ( SAECG ) in risk stratification of sudden cardiac death and arrhythmogenic events , the clinical characteristics of these postinfarction patients were performed in a follow-up-period .

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Komplikation is an umlsterm, Patienten is an umlsterm, Spezifitaet is an umlsterm, Ultraschalldiagnostik is an umlsterm, Ultraschallkriterien is an umlsterm, Patienten is an umlsterm, Ultraschalluntersuchung is an umlsterm, parenterale Ernaehrung is an umlsterm, Patienten is an umlsterm, Gallenblasenwand is an umlsterm, Gallenblasenwand is an umlsterm, Diagnose is an umlsterm, Sonographiebefund is an umlsterm

DerChirurg.70680898.ger.abstr_task0

Sentence: Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden .

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[ "umlsterm" ]

Komplikation is an umlsterm, Patienten is an umlsterm, Spezifitaet is an umlsterm, Ultraschalldiagnostik is an umlsterm, Ultraschallkriterien is an umlsterm, Patienten is an umlsterm, Ultraschalluntersuchung is an umlsterm, parenterale Ernaehrung is an umlsterm, Patienten is an umlsterm, Gallenblasenwand is an umlsterm, Gallenblasenwand is an umlsterm, Diagnose is an umlsterm, Sonographiebefund is an umlsterm

DerChirurg.70680898.ger.abstr_task1

Sentence: Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden . Instructions: please typing these entity words according to sentence: Komplikation, Patienten, Spezifitaet, Ultraschalldiagnostik, Ultraschallkriterien, Patienten, Ultraschalluntersuchung, parenterale Ernaehrung, Patienten, Gallenblasenwand, Gallenblasenwand, Diagnose, Sonographiebefund Options: umlsterm

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Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden .

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[ "umlsterm" ]

Komplikation, Patienten, Spezifitaet, Ultraschalldiagnostik, Ultraschallkriterien, Patienten, Ultraschalluntersuchung, parenterale Ernaehrung, Patienten, Gallenblasenwand, Gallenblasenwand, Diagnose, Sonographiebefund

DerChirurg.70680898.ger.abstr_task2

Sentence: Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden . Instructions: please extract entity words from the input sentence

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Zusammenfassung . Eine oft unbemerkte jedoch potentiell fatale Komplikation , im posttraumatischen Verlauf intensivpflichtiger Patienten ist die reaktive akute Cholecystitis . Aufgrund der hohen Spezifitaet der Ultraschalldiagnostik im biliaeren System war es unser Ziel , die Ultraschallkriterien zur fruehzeitigen Objektivierung der posttraumatischen Cholecystitis zu ueberpruefen . Prospektiv wurde ueber 12 Monate bei 40 beatmungspflichtigen Patienten an jeweils 7 Tagen eine Ultraschalluntersuchung des Oberbauchs durchgefuehrt . Die Ergebnisse zeigen , dass Beatmung parenterale Ernaehrung und die Auswirkungen , einer zuvor stattgehabten Traumatisierung des Patienten zu einer verzoegerten Verdickung ( 28/40 ) bzw. Dreischichtung ( 9/40 ) der Gallenblasenwand fuehren kann . Sonographisch waren in 22,5 % ( 9/40 ) die Zeichen einer akuten Cholecystitis nachweisbar . In Korrelation mit den klinischen Parametern ergab sich jedoch nur in 2 Faellen die Indikation zur Cholecystektomie . Unsere Studie zeigt , dass das morphologische Korrelat einer verdickten dreischichtigen Gallenblasenwand auch ohne zugrundeliegende Cholecystitis im Rahmen systemischer Veraenderungen auftreten kann . Eine sichere Diagnose einer akuten reaktiven Cholecystitis mit der Indikation zur Cholecystektomie konnte bei pathologischem Sonographiebefund nur in enger Korrelation mit klinischen Parametern gestellt werden .

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[ "umlsterm" ]

Thromboseprophylaxe is an umlsterm, Rechtsprechung is an umlsterm, Patient is an umlsterm, Verletzung is an umlsterm, Thromboseprophylaxe is an umlsterm, Gesellschaft is an umlsterm, Thromboseprophylaxe is an umlsterm, Internet is an umlsterm, Arzt is an umlsterm, Fachgesellschaften is an umlsterm, Strafrecht is an umlsterm, Rechtssystematik is an umlsterm, Lungenembolie is an umlsterm

DerUnfallchirurg.71000754.ger.abstr_task0

Sentence: Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen .

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[ "umlsterm" ]

Thromboseprophylaxe is an umlsterm, Rechtsprechung is an umlsterm, Patient is an umlsterm, Verletzung is an umlsterm, Thromboseprophylaxe is an umlsterm, Gesellschaft is an umlsterm, Thromboseprophylaxe is an umlsterm, Internet is an umlsterm, Arzt is an umlsterm, Fachgesellschaften is an umlsterm, Strafrecht is an umlsterm, Rechtssystematik is an umlsterm, Lungenembolie is an umlsterm

DerUnfallchirurg.71000754.ger.abstr_task1

Sentence: Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen . Instructions: please typing these entity words according to sentence: Thromboseprophylaxe, Rechtsprechung, Patient, Verletzung, Thromboseprophylaxe, Gesellschaft, Thromboseprophylaxe, Internet, Arzt, Fachgesellschaften, Strafrecht, Rechtssystematik, Lungenembolie Options: umlsterm

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Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen .

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[ "umlsterm" ]

Thromboseprophylaxe, Rechtsprechung, Patient, Verletzung, Thromboseprophylaxe, Gesellschaft, Thromboseprophylaxe, Internet, Arzt, Fachgesellschaften, Strafrecht, Rechtssystematik, Lungenembolie

DerUnfallchirurg.71000754.ger.abstr_task2

Sentence: Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen . Instructions: please extract entity words from the input sentence

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Zur Frage , bei wem , wie und wie lange Thromboseprophylaxe in der Unfallchirurgie durchzufuehren ist , hat die Rechtsprechung bisher keine konkreten Vorschriften entwickelt . Allerdings hat der BGH 1995 entschieden , dass der Patient sowohl ueber moegliche Behandlungsalternativen einer Verletzung aufgeklaert werden muesse , wie auch ueber die dann jeweils moegliche Form der Thromboseprophylaxe . Dies , in Verbindung mit der Tatsache , dass Leitlinien der Deutschen Gesellschaft fuer Phlebologie zur Thromboseprophylaxe im Internet verbreitet werden , kann im Zivilprozess , wo es um Schadensersatz und Schmerzensgeld geht , erhebliche Auswirkungen haben . Da der Arzt im Zivilprozess die ordnungsgemaess erfolgte Aufklaerung beweisen muss und die Leitlinien als state of the art " " missverstanden werden koennten , wird eine Liste der zu beachtenden Aufklaerungspunkte vorgestellt und auf die Problematik der Leitlinien der Medizinischen Fachgesellschaften hingewiesen . Im Strafrecht ist dagegen nach der deutschen Rechtssystematik auch bei toedlicher Lungenembolie nach unterlassener oder fehlerhafter Prophylaxe eine Verurteilung praktisch fast so gut wie ausgeschlossen .

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[ "umlsterm" ]

Aranesp is a BRAND

Darbepoetin alfa_ddi_task0

Sentence: No formal drug interaction studies of Aranesp have been performed. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: BRAND

[ "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O" ]

No formal drug interaction studies of Aranesp have been performed.

[ "No", "formal", "drug", "interaction", "studies", "of", "Aranesp", " ", "have", "been", "performed", "." ]

[ "BRAND" ]

Aranesp is a BRAND

Darbepoetin alfa_ddi_task1

Sentence: No formal drug interaction studies of Aranesp have been performed. Instructions: please typing these entity words according to sentence: Aranesp Options: BRAND

[ "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O" ]

No formal drug interaction studies of Aranesp have been performed.

[ "No", "formal", "drug", "interaction", "studies", "of", "Aranesp", " ", "have", "been", "performed", "." ]

[ "BRAND" ]

Aranesp

Darbepoetin alfa_ddi_task2

Sentence: No formal drug interaction studies of Aranesp have been performed. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "B-BRAND", "O", "O", "O", "O", "O" ]

No formal drug interaction studies of Aranesp have been performed.

[ "No", "formal", "drug", "interaction", "studies", "of", "Aranesp", " ", "have", "been", "performed", "." ]

[ "BRAND" ]

Abstract is an umlsterm, cytokine is an umlsterm, light is an umlsterm, leukocyte is an umlsterm, release is an umlsterm, concentration is an umlsterm, IL-12 is an umlsterm, polytrauma is an umlsterm, Methods is an umlsterm, concentrations is an umlsterm, IL-12 is an umlsterm, polytrauma is an umlsterm, patients is an umlsterm, donor is an umlsterm, values is an umlsterm, intensive care is an umlsterm, ELISA is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, normal range is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, survivors is an umlsterm, Patients is an umlsterm, single is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, IL-12 is an umlsterm, values is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, patients is an umlsterm, intensive care unit is an umlsterm, MODS is an umlsterm, CRP is an umlsterm, values is an umlsterm, leukocyte counts is an umlsterm, Correlation analysis is an umlsterm, IL-12 is an umlsterm, values is an umlsterm, MODS is an umlsterm, injuries is an umlsterm, overall is an umlsterm, IL-12 is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, survivors is an umlsterm, patients is an umlsterm, IL-12 is an umlsterm, risk of is an umlsterm, multi - organ failure is an umlsterm

DerChirurg.00711126.eng.abstr_task0

Sentence: Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure .

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[ "umlsterm" ]

Abstract is an umlsterm, cytokine is an umlsterm, light is an umlsterm, leukocyte is an umlsterm, release is an umlsterm, concentration is an umlsterm, IL-12 is an umlsterm, polytrauma is an umlsterm, Methods is an umlsterm, concentrations is an umlsterm, IL-12 is an umlsterm, polytrauma is an umlsterm, patients is an umlsterm, donor is an umlsterm, values is an umlsterm, intensive care is an umlsterm, ELISA is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, IL-12 is an umlsterm, normal range is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, survivors is an umlsterm, Patients is an umlsterm, single is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, IL-12 is an umlsterm, values is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, thorax is an umlsterm, trauma is an umlsterm, pneumonia is an umlsterm, patients is an umlsterm, intensive care unit is an umlsterm, MODS is an umlsterm, CRP is an umlsterm, values is an umlsterm, leukocyte counts is an umlsterm, Correlation analysis is an umlsterm, IL-12 is an umlsterm, values is an umlsterm, MODS is an umlsterm, injuries is an umlsterm, overall is an umlsterm, IL-12 is an umlsterm, Patients is an umlsterm, IL-12 is an umlsterm, survivors is an umlsterm, patients is an umlsterm, IL-12 is an umlsterm, risk of is an umlsterm, multi - organ failure is an umlsterm

DerChirurg.00711126.eng.abstr_task1

Sentence: Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure . Instructions: please typing these entity words according to sentence: Abstract, cytokine, light, leukocyte, release, concentration, IL-12, polytrauma, Methods, concentrations, IL-12, polytrauma, patients, donor, values, intensive care, ELISA, Patients, IL-12, IL-12, IL-12, IL-12, normal range, Patients, IL-12, thorax, trauma, pneumonia, survivors, Patients, single, thorax, trauma, pneumonia, thorax, trauma, IL-12, values, Patients, IL-12, thorax, trauma, pneumonia, patients, intensive care unit, MODS, CRP, values, leukocyte counts, Correlation analysis, IL-12, values, MODS, injuries, overall, IL-12, Patients, IL-12, survivors, patients, IL-12, risk of, multi - organ failure Options: umlsterm

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Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure .

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[ "umlsterm" ]

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DerChirurg.00711126.eng.abstr_task2

Sentence: Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure . Instructions: please extract entity words from the input sentence

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Abstract . Introduction : Interleukin-12-p70 ( IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain ( p40) and a light chain ( p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma . Methods : We daily analyzed systemic concentrations of IL-12 in polytrauma patients ( n = 37 , mean ISS 33.9 ) in comparison to healthy donor values during intensive care course by ELISA . Patients were divided according to their mean IL-12 levels into those with elevated IL-12 ( group 1 , n = 7 ) , those with decreased IL-12 ( group 2 , n = 4 ) and those with IL-12 in the normal range ( group 3 , n = 26 ) . Results : Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml . The common clinical feature of group 1 was a thorax trauma in combination with pneumonia ( 85 % survivors ) . Patients with single thorax trauma or pneumonia without thorax trauma ( group 3 ) showed normal IL-12 values . Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed . The groups significantly differ in their stay in the intensive care unit , in TISS , in MODS score and in respiratory ratio , but not in ISS , mean CRP values and leukocyte counts . Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters , with the exception of a negative correlation of p70 and ISS ( r = -0 . 785 ) or MODS score ( r = -0 . 314 ) in group 1. Conclusions : After major injuries there is no overall suppression of IL-12 formation . Patients with normal or elevated IL-12 levels belong mainly to the survivors , whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure .

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[ "umlsterm" ]

monocular augmented reality technology is a Intervention_Other, Augmented reality ( AR ) technologies is a Intervention_Educational, AR technology is a Intervention_Other, 45 is a Participant_Sample-size, visual impairment is a Participant_Condition, conventional working aids ( paper - based documents ) to support the task processing is a Intervention_Educational, HMD unit that was switched off . is a Intervention_Other, HMD without any additional aids . is a Intervention_Educational, mental strain is a Outcome_Mental, concentration - test performance is a Outcome_Mental, physical or mental complaints is a Outcome_Physical, higher pressure is a Outcome_Physical, blurred vision in both eyes is a Outcome_Physical, headaches is a Outcome_Physical, ergonomic hardware design is a Outcome_Physical

31922_task0

Sentence: [ Potentials of monocular augmented reality technology in automobile production ] . INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Participant_Condition, Intervention_Educational, Intervention_Other, Outcome_Physical, Participant_Sample-size, Outcome_Mental

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[ Potentials of monocular augmented reality technology in automobile production ] . INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed .

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[ "Intervention_Educational", "Intervention_Other", "Outcome_Mental", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]

monocular augmented reality technology is a Intervention_Other, Augmented reality ( AR ) technologies is a Intervention_Educational, AR technology is a Intervention_Other, 45 is a Participant_Sample-size, visual impairment is a Participant_Condition, conventional working aids ( paper - based documents ) to support the task processing is a Intervention_Educational, HMD unit that was switched off . is a Intervention_Other, HMD without any additional aids . is a Intervention_Educational, mental strain is a Outcome_Mental, concentration - test performance is a Outcome_Mental, physical or mental complaints is a Outcome_Physical, higher pressure is a Outcome_Physical, blurred vision in both eyes is a Outcome_Physical, headaches is a Outcome_Physical, ergonomic hardware design is a Outcome_Physical

31922_task1

Sentence: [ Potentials of monocular augmented reality technology in automobile production ] . INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed . Instructions: please typing these entity words according to sentence: monocular augmented reality technology, Augmented reality ( AR ) technologies, AR technology, 45, visual impairment, conventional working aids ( paper - based documents ) to support the task processing, HMD unit that was switched off ., HMD without any additional aids ., mental strain, concentration - test performance, physical or mental complaints, higher pressure, blurred vision in both eyes, headaches, ergonomic hardware design Options: Participant_Condition, Intervention_Educational, Intervention_Other, Outcome_Physical, Participant_Sample-size, Outcome_Mental

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[ Potentials of monocular augmented reality technology in automobile production ] . INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed .

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[ "Intervention_Educational", "Intervention_Other", "Outcome_Mental", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]

monocular augmented reality technology, Augmented reality ( AR ) technologies, AR technology, 45, visual impairment, conventional working aids ( paper - based documents ) to support the task processing, HMD unit that was switched off ., HMD without any additional aids ., mental strain, concentration - test performance, physical or mental complaints, higher pressure, blurred vision in both eyes, headaches, ergonomic hardware design

31922_task2

Sentence: [ Potentials of monocular augmented reality technology in automobile production ] . INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed . Instructions: please extract entity words from the input sentence

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[ Potentials of monocular augmented reality technology in automobile production ] . INTRODUCTION Augmented reality ( AR ) technologies can enrich the real environment with visual data , which has potential benefits for optimising the operator 's working process . It offers the possibility to provide context-sensitive information independently of the user 's location and position . Data are presented to the dominant eye on a semi-transparent mirror using a head-mounted display ( HMD ) unit that works with retinal laser technology . In this study the potential benefits and drawbacks of this new AR technology were evaluated . MATERIALS AND METHODS 45 participants without any visual impairment were randomly assigned to 3 groups and completed a variety of tasks during a simulated working day . Group 1 received conventional working aids ( paper-based documents ) to support the task processing . Group 2 additionally wore an HMD unit that was switched off . Group 3 wore a functioning HMD without any additional aids . Evaluation was carried out by means of a standardised questionnaire ( BMS ) and a concentration test ( " d2 Aufmerksamkeits-Belastungs-Test " ) . RESULTS No significant differences between the 3 groups were found in terms of mental strain , concentration-test performance and physical or mental complaints reported in a follow-up interview . Around 20 % of the subjects noticed a higher pressure and blurred vision in both eyes as well as headaches . Half of the participants complained about deficiencies concerning the ergonomic hardware design of the AR system . DISCUSSION Changes in objective ophthalmological investigation parameters were not observed . Subjects reported reduced acceptance of the HMD based on non-ophthalmological reasons , for example , the weight of the unit or the length of the cable . However , for some specific working tasks , advantages in process optimisation and operator support were observed .

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[ "Intervention_Educational", "Intervention_Other", "Outcome_Mental", "Outcome_Physical", "Participant_Condition", "Participant_Sample-size" ]

IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, TNF - alpha is a Protein, TNF - alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein

389_task0

Sentence: Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation.

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[ "Protein" ]

IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein, TNF - alpha is a Protein, TNF - alpha is a Protein, IkB alpha is a Protein, IkB alpha is a Protein

389_task1

Sentence: Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation. Instructions: please typing these entity words according to sentence: IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, TNF - alpha, TNF - alpha, IkB alpha, IkB alpha Options: Protein

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Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation.

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[ "Protein" ]

IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, IkB alpha, TNF - alpha, TNF - alpha, IkB alpha, IkB alpha

389_task2

Sentence: Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation. Instructions: please extract entity words from the input sentence

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Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways. The Ca(2+)-dependent phosphatase calcineurin, a target of FK506 and CsA, synergizes with PKC-induced activation of nuclear factor (NF)-kappa B in T cell lines. We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to NF-kappa B activation. While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B. Having previously shown that Ca(2+)- and PKC-dependent pathways synergize by accelerating the degradation of IkB alpha, we focused on the regulation of IkB alpha phosphorylation. While PKC-dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines, co-activation of Ca(2+)-dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. Activation of Ca(2+)-dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in U937 cells. Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus. Contrary to the interaction with PKC, Ca(2+)-dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation, but at the level of its degradation. These results indicate that Ca(2+)-dependent pathways, including the phosphatase calcineurin, participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC-dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation.

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[ "Protein" ]

Akathisie is an umlsterm, Patienten is an umlsterm, Verwendung is an umlsterm, stressevozierenden is an umlsterm, Akathisie is an umlsterm, Stressinduktion is an umlsterm, Akathisie is an umlsterm, Bewegungsstoerungen is an umlsterm

DerNervenarzt.00710030.ger.abstr_task0

Sentence: In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein .

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[ "umlsterm" ]

Akathisie is an umlsterm, Patienten is an umlsterm, Verwendung is an umlsterm, stressevozierenden is an umlsterm, Akathisie is an umlsterm, Stressinduktion is an umlsterm, Akathisie is an umlsterm, Bewegungsstoerungen is an umlsterm

DerNervenarzt.00710030.ger.abstr_task1

Sentence: In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein . Instructions: please typing these entity words according to sentence: Akathisie, Patienten, Verwendung, stressevozierenden, Akathisie, Stressinduktion, Akathisie, Bewegungsstoerungen Options: umlsterm

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In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein .

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[ "umlsterm" ]

Akathisie, Patienten, Verwendung, stressevozierenden, Akathisie, Stressinduktion, Akathisie, Bewegungsstoerungen

DerNervenarzt.00710030.ger.abstr_task2

Sentence: In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein . Instructions: please extract entity words from the input sentence

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In dieser Studie wurden die Wirkungen verschiedener Aktivierungstests auf die motorische und psychische Symptomatik der akuten neuroleptikainduzierten Akathisie an 11 Patienten unter Verwendung der Hillside- und Barnes-Akathisie-Skalen sowie der Videotape Rating Technique experimentell untersucht . Zur motorischen Aktivierung wurde Finger-Tapping eingesetzt . Die kognitive Aktivierung bestand in sequenziellem Kopfrechnen , wobei unterschieden wurde zwischen einerseits nur geringfuegig und andererseits staerker stressevozierenden Aufgaben , und zwar durch den Einsatz von Zeitdruck bzw. einen hohen Schwierigkeitsgrad der betreffenden Rechenoperationen . Motorische und gering belastende kognitive Aktivierung reduzierte sowohl motorische als auch psychische Symptome der Akathisie statistisch signifikant . Dagegen fuehrte zusaetzliche Stressinduktion im Rahmen der kognitiven Aktivierung zu einer Aufhebung dieses Effekts sowie zu einer Zunahme motorischer wie auch psychischer Symptome unmittelbar nach Beendigung der Aktivierungsaufgabe . Diese moeglicherweise spezifischen Wirkungen von Aktivierungstests auf die Symptomatik koennten bei der differenzialdiagnostischen Abgrenzung der akuten neuroleptikainduzierten Akathisie von anderen neuroleptikainduzierten und extrapyramidalen Bewegungsstoerungen nuetzlich sein .

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[ "umlsterm" ]

Pregnancy is a Condition, hypersensitivity is a Condition, study drug is a Drug, ferric carboxymaltose is a Drug, Known or suspected is a Scope, haemoglobinopathy / thalassaemia is a Scope, Bone marrow disease is a Condition, Haemochromatosis is a Condition, Renal dialysis is a Procedure, Erythropoietin or IV iron is a Scope, in the previous 4 weeks is a Temporal

NCT02632760_exc_task0

Sentence: Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Procedure, Scope, Drug

[ "B-Condition", "O", "O", "B-Condition", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]

Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks

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[ "Scope", "Temporal", "Drug", "Condition", "Procedure", "Mood" ]

Pregnancy is a Condition, hypersensitivity is a Condition, study drug is a Drug, ferric carboxymaltose is a Drug, Known or suspected is a Scope, haemoglobinopathy / thalassaemia is a Scope, Bone marrow disease is a Condition, Haemochromatosis is a Condition, Renal dialysis is a Procedure, Erythropoietin or IV iron is a Scope, in the previous 4 weeks is a Temporal

NCT02632760_exc_task1

Sentence: Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks Instructions: please typing these entity words according to sentence: Pregnancy, hypersensitivity, study drug, ferric carboxymaltose, Known or suspected, haemoglobinopathy / thalassaemia, Bone marrow disease, Haemochromatosis, Renal dialysis, Erythropoietin or IV iron, in the previous 4 weeks Options: Temporal, Condition, Procedure, Scope, Drug

[ "B-Condition", "O", "O", "B-Condition", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]

Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks

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[ "Scope", "Temporal", "Drug", "Condition", "Procedure", "Mood" ]

Pregnancy, hypersensitivity, study drug, ferric carboxymaltose, Known or suspected, haemoglobinopathy / thalassaemia, Bone marrow disease, Haemochromatosis, Renal dialysis, Erythropoietin or IV iron, in the previous 4 weeks

NCT02632760_exc_task2

Sentence: Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks Instructions: please extract entity words from the input sentence

[ "B-Condition", "O", "O", "B-Condition", "O", "B-Drug", "I-Drug", "O", "B-Drug", "I-Drug", "O", "O", "O", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "B-Scope", "I-Scope", "I-Scope", "O", "B-Condition", "I-Condition", "I-Condition", "O", "B-Condition", "O", "B-Procedure", "I-Procedure", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "B-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "I-Temporal", "O" ]

Pregnancy Known hypersensitivity to study drug (ferric carboxymaltose or equivalent) or its excipients Known or suspected haemoglobinopathy/thalassaemia Bone marrow disease Haemochromatosis Renal dialysis Erythropoietin or IV iron in the previous 4 weeks

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[ "Scope", "Temporal", "Drug", "Condition", "Procedure", "Mood" ]

diagnostic laboratory tests is a Procedure, complete blood count is a Procedure, acute phase reactants is a Procedure, erythrocyte sedimentation rate and C - reactive protein is a Scope, acute is a Qualifier, non - specific low back pain is a Condition, history and physical examinations is a Scope, pain is a Condition, area between the 12th rib and buttock crease is a Qualifier, without is a Negation, leg pain is a Condition, Female is a Person, male is a Person, 20 - 80 years is a Value, age is a Person, Low back pain is a Condition, less than six weeks ' duration is a Temporal, at least moderate pain intensity is a Scope, NRS < U+2267>4 is a Scope

NCT03171987_inc_task0

Sentence: All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Temporal, Condition, Qualifier, Value, Person, Procedure, Negation, Scope

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All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4)

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[ "Scope", "Qualifier", "Procedure", "Temporal", "Condition", "Value", "Measurement", "Observation", "Negation", "Person" ]

diagnostic laboratory tests is a Procedure, complete blood count is a Procedure, acute phase reactants is a Procedure, erythrocyte sedimentation rate and C - reactive protein is a Scope, acute is a Qualifier, non - specific low back pain is a Condition, history and physical examinations is a Scope, pain is a Condition, area between the 12th rib and buttock crease is a Qualifier, without is a Negation, leg pain is a Condition, Female is a Person, male is a Person, 20 - 80 years is a Value, age is a Person, Low back pain is a Condition, less than six weeks ' duration is a Temporal, at least moderate pain intensity is a Scope, NRS < U+2267>4 is a Scope

NCT03171987_inc_task1

Sentence: All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4) Instructions: please typing these entity words according to sentence: diagnostic laboratory tests, complete blood count, acute phase reactants, erythrocyte sedimentation rate and C - reactive protein, acute, non - specific low back pain, history and physical examinations, pain, area between the 12th rib and buttock crease, without, leg pain, Female, male, 20 - 80 years, age, Low back pain, less than six weeks ' duration, at least moderate pain intensity, NRS < U+2267>4 Options: Temporal, Condition, Qualifier, Value, Person, Procedure, Negation, Scope

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All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4)

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[ "Scope", "Qualifier", "Procedure", "Temporal", "Condition", "Value", "Measurement", "Observation", "Negation", "Person" ]

diagnostic laboratory tests, complete blood count, acute phase reactants, erythrocyte sedimentation rate and C - reactive protein, acute, non - specific low back pain, history and physical examinations, pain, area between the 12th rib and buttock crease, without, leg pain, Female, male, 20 - 80 years, age, Low back pain, less than six weeks ' duration, at least moderate pain intensity, NRS < U+2267>4

NCT03171987_inc_task2

Sentence: All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4) Instructions: please extract entity words from the input sentence

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All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study. A primary complaint of pain in the area between the 12th rib and buttock crease without leg pain Female or male, 20 - 80 years of age Low back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4)

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Sehnervenschaeden is an umlsterm, Behandlung is an umlsterm, kopfverletzten is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Sehnervenschaeden is an umlsterm, Element is an umlsterm, Sehnervenschaeden is an umlsterm, Bewusstseinsgrad is an umlsterm, Patienten is an umlsterm, Sehnervenschaeden is an umlsterm, Therapie is an umlsterm, Arbeit is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Sehnervenschaeden is an umlsterm, Patienten is an umlsterm, Therapie is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Therapieerfolg is an umlsterm, Patienten is an umlsterm, Patienten is an umlsterm, Behandlung is an umlsterm, Sehnervenschaedigung is an umlsterm

MundKieferGesichtschirurgie.8002s107.ger.abstr_task0

Sentence: Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen .

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MundKieferGesichtschirurgie.8002s107.ger.abstr_task1

Sentence: Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen . Instructions: please typing these entity words according to sentence: Sehnervenschaeden, Behandlung, kopfverletzten, Patienten, Patienten, Sehnervenschaeden, Element, Sehnervenschaeden, Bewusstseinsgrad, Patienten, Sehnervenschaeden, Therapie, Arbeit, Patienten, Therapie, Sehnervenschaeden, Patienten, Therapie, Patienten, Patienten, Therapieerfolg, Patienten, Patienten, Behandlung, Sehnervenschaedigung Options: umlsterm

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Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen .

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[ "umlsterm" ]

Sehnervenschaeden, Behandlung, kopfverletzten, Patienten, Patienten, Sehnervenschaeden, Element, Sehnervenschaeden, Bewusstseinsgrad, Patienten, Sehnervenschaeden, Therapie, Arbeit, Patienten, Therapie, Sehnervenschaeden, Patienten, Therapie, Patienten, Patienten, Therapieerfolg, Patienten, Patienten, Behandlung, Sehnervenschaedigung

MundKieferGesichtschirurgie.8002s107.ger.abstr_task2

Sentence: Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen . Instructions: please extract entity words from the input sentence

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Traumatische Sehnervenschaeden stellen eine klinische Herausforderung dar , da ihre Frueherkennung und Behandlung nicht systematisiert sind . Neuroophthalmologische Tests sind prinzipiell sichere Verfahren zur Feststellung eines Sehbahnschadens , jedoch koennen sie lediglich in ca. 30% der schwer kopfverletzten Patienten erfolgreich angewendet werden ; besonders bei polytraumatisierten Patienten sind Sehnervenschaeden schwer zu erheben . Wir haben mit Hilfe der bekannten Blitz-VEP ERG-Untersuchung ein sicheres diagnostisches Element zur Frueherkennung traumatischer Sehnervenschaeden unabhaengig vom Bewusstseinsgrad des Verletzten erarbeitet . Neben dem Problem der Frueherkennung besteht Unsicherheit im Hinblick auf eine klare therapeutische Richtlinie fuer Patienten mit traumatischen Sehnervenschaeden - konservative vs. chirurgische Therapie . Ziel dieser Arbeit war es , unabhaengig von der Kooperationsfaehigkeit des Patienten einen verlaesslichen Plan zur interdisziplinaeren Frueherkennung und Therapie traumatischer Sehnervenschaeden auf der Basis von neuroophthalmologischen , Spiral-CT- und neurophysiologischen Befunden zu erstellen , so dass fuer jeden Patienten eine klare Richtlinie fuer oder gegen eine Therapie vorliegt . Insgesamt wurden 52 Patienten mit Hilfe dieses diagnostischen Stufenplans untersucht ; hiervon konnten bei insgesamt 20 Patienten posttraumatische afferente Sehbahnschaeden diagnostiziert werden . Obwohl der Beweis fuer einen Therapieerfolg nur schwer zu erbringen ist , konnte aus der Gruppe der kooperativen Patienten bei 3 einseitig amaurotischen Patienten nach unmittelbarer Einleitung der kombinierten konservativen und operativen Behandlung eine partielle Restitution der geschaedigten Sehbahnfunktion erzielt werden . In den meisten Kliniken wird nach wie vor das Problem der traumatischen Sehnervenschaedigung nach dem Wait-and-see-Prinzip angegangen . Wir halten ein solches Vorgehen fuer nicht gerechtfertigt , da es klare Alternativen gibt , die im folgenden vorgestellt werden sollen .

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[ "umlsterm" ]

estramustine is a CHEMICAL

1908244_task0

Sentence: The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent.

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

estramustine is a CHEMICAL

1908244_task1

Sentence: The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent. Instructions: please typing these entity words according to sentence: estramustine Options: CHEMICAL

[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent.

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

estramustine

1908244_task2

Sentence: The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The effect of estramustine derivatives on microtubule assembly in vitro depends on the charge of the substituent.

[ "The", "effect", "of", "estramustine", "derivatives", "on", "microtubule", "assembly", "in", "vitro", "depends", "on", "the", "charge", "of", "the", "substituent", "." ]

[ "GENE-N", "CHEMICAL", "GENE-Y" ]

binding site is a Entity, nuclear factor - kappaB is a Entity, NF - kappaB is a Entity, promoter region of the germline Cepsilon gene is a Entity, NF - kappaB is a Entity, germline Cepsilon is a Entity, n - acetyl - L - cysteine is a Entity, NAC is a Entity, NF - kappaB is a Entity, IL-4 is a Protein, CD40 is a Protein, IL-4 is a Protein, signal transducers and activators of transcription ( STAT ) 6 is a Protein, NF - kappaB is a Entity, NAC is a Entity, decoy oligodeoxynucleotides is a Entity, NF - kappaB is a Entity, STAT6 is a Protein, germline Cepsilon is a Entity, decoy oligodeoxynucleotides is a Entity, germline Cepsilon is a Entity, germline Cepsilon is a Entity, NAC is a Entity, decoy oligodeoxynucleotide is a Entity, NAC is a Entity, NAC is a Entity, IL-4 is a Protein, CD40 is a Protein, CD40 is a Protein, CD23 is a Protein, NF - kappaB is a Entity, STAT6 is a Protein, germline Cepsilon is a Entity, IL-4 is a Protein, NF - kappaB is a Entity, germline Cepsilon is a Entity

798_task0

Sentence: A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB. The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

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A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB. The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE.

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[ "Protein", "Entity" ]

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798_task1

Sentence: A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB. The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE. Instructions: please typing these entity words according to sentence: binding site, nuclear factor - kappaB, NF - kappaB, promoter region of the germline Cepsilon gene, NF - kappaB, germline Cepsilon, n - acetyl - L - cysteine, NAC, NF - kappaB, IL-4, CD40, IL-4, signal transducers and activators of transcription ( STAT ) 6, NF - kappaB, NAC, decoy oligodeoxynucleotides, NF - kappaB, STAT6, germline Cepsilon, decoy oligodeoxynucleotides, germline Cepsilon, germline Cepsilon, NAC, decoy oligodeoxynucleotide, NAC, NAC, IL-4, CD40, CD40, CD23, NF - kappaB, STAT6, germline Cepsilon, IL-4, NF - kappaB, germline Cepsilon Options: Entity, Protein

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A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB. The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE.

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[ "Protein", "Entity" ]

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798_task2

Sentence: A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB. The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE. Instructions: please extract entity words from the input sentence

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A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB. The binding site for nuclear factor-kappaB (NF-kappaB) is present at the promoter region of the germline Cepsilon gene, but there is little information on whether this factor is involved in regulating IgE synthesis by human B cells. Accordingly, we studied the role of NF-kappaB in germline Cepsilon transcription by using two human Burkitt's lymphoma B cell lines, DND39 and DG75. In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody. Although IL-4 activated signal transducers and activators of transcription (STAT) 6 in addition to NF-kappaB, NAC treatment or the transfection of decoy oligodeoxynucleotides for NF-kappaB or STAT6 only partly blocked IL-4-induced germline Cepsilon transcription. However, these two decoy oligodeoxynucleotides together almost completely abrogated IL-4-induced germline Cepsilon transcription. Of note, CD40-mediated enhancement of IL-4-driven germline Cepsilon transcription was markedly decreased by NAC or by a decoy oligodeoxynucleotide for NF-kappaB. The effect of NAC was also examined on deletional switch recombination underlying the isotype switch to IgE. NAC inhibited the generation of Smu/Sepsilon switch fragments in normal human B cells costimulated with IL-4 and anti-CD40 monoclonal antibody. It also abolished IL-4-induced upregulation of CD40 but promoted upregulation of CD23. These results suggest that coordination of NF-kappaB and STAT6 may be required for induction of germline Cepsilon transcription by IL-4, and that CD40-mediated NF-kappaB activation may be important in regulating both enhancement of germline Cepsilon transcription and class switching to IgE.

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[ "Protein", "Entity" ]

adjuvant radiotherapy is a Procedure, intra - abdominal inflammation is a Condition, imaging and / or laboratory is a Scope, abscess or cholecystitis is a Scope, chronic pancreatitis is a Condition, pancreatic polypeptide producing endocrine tumor is a Condition, Poorly regulated is a Qualifier, diabetes is a Condition, > 200 mg / dl (= 11 mmol / l ) is a Qualifier

NCT02425774_exc_task0

Sentence: adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l)) Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Scope, Condition, Procedure, Qualifier

[ "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O" ]

adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l))

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[ "Measurement", "Condition", "Scope", "Qualifier", "Procedure", "Multiplier", "Value" ]

adjuvant radiotherapy is a Procedure, intra - abdominal inflammation is a Condition, imaging and / or laboratory is a Scope, abscess or cholecystitis is a Scope, chronic pancreatitis is a Condition, pancreatic polypeptide producing endocrine tumor is a Condition, Poorly regulated is a Qualifier, diabetes is a Condition, > 200 mg / dl (= 11 mmol / l ) is a Qualifier

NCT02425774_exc_task1

Sentence: adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l)) Instructions: please typing these entity words according to sentence: adjuvant radiotherapy, intra - abdominal inflammation, imaging and / or laboratory, abscess or cholecystitis, chronic pancreatitis, pancreatic polypeptide producing endocrine tumor, Poorly regulated, diabetes, > 200 mg / dl (= 11 mmol / l ) Options: Scope, Condition, Procedure, Qualifier

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adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l))

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[ "Measurement", "Condition", "Scope", "Qualifier", "Procedure", "Multiplier", "Value" ]

adjuvant radiotherapy, intra - abdominal inflammation, imaging and / or laboratory, abscess or cholecystitis, chronic pancreatitis, pancreatic polypeptide producing endocrine tumor, Poorly regulated, diabetes, > 200 mg / dl (= 11 mmol / l )

NCT02425774_exc_task2

Sentence: adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l)) Instructions: please extract entity words from the input sentence

[ "B-Procedure", "I-Procedure", "O", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "I-Scope", "I-Scope", "O", "O", "O", "O", "B-Scope", "I-Scope", "I-Scope", "O", "O", "B-Condition", "I-Condition", "O", "B-Condition", "I-Condition", "I-Condition", "I-Condition", "I-Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Qualifier", "I-Qualifier", "B-Condition", "O", "B-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "I-Qualifier", "O", "O" ]

adjuvant radiotherapy evident intra-abdominal inflammation (diagnosed by imaging and/or laboratory results, including an abscess or cholecystitis) chronic pancreatitis pancreatic polypeptide producing endocrine tumor American Society of Anesthesiologists physical-health status classification (ASA-PS)>3 Poorly regulated diabetes (>200 mg/dl (=11 mmol/l))

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[ "Measurement", "Condition", "Scope", "Qualifier", "Procedure", "Multiplier", "Value" ]

interleukin-8 is a Protein, Interleukin-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, MEK1 is a Protein, IL-8 is a Protein

9916078_task0

Sentence: Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.

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[ "Protein" ]

interleukin-8 is a Protein, Interleukin-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, IL-8 is a Protein, MEK1 is a Protein, IL-8 is a Protein

9916078_task1

Sentence: Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. Instructions: please typing these entity words according to sentence: interleukin-8, Interleukin-8, IL-8, IL-8, IL-8, IL-8, MEK1, IL-8 Options: Protein

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Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.

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[ "Protein" ]

interleukin-8, Interleukin-8, IL-8, IL-8, IL-8, IL-8, MEK1, IL-8

9916078_task2

Sentence: Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions. Instructions: please extract entity words from the input sentence

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Involvement of mitogen-activated protein kinase pathways in interleukin-8 production by human monocytes and polymorphonuclear cells stimulated with lipopolysaccharide or Mycoplasma fermentans membrane lipoproteins. Interleukin-8 (IL-8) is a chemokine that belongs to the alpha-chemokine or CXC subfamily and is produced by a wide variety of human cells, including monocytes and polymorphonuclear cells (PMN). IL-8 is secreted in response to inflammatory stimuli, notably bacterial products such as lipopolysaccharide (LPS), but little is known about the mechanisms by which these agents mediate IL-8 induction. In this report, we show that Mycoplasma fermentans lipid-associated membrane proteins (LAMPf) induce the production of high levels of IL-8 by THP-1 (human monocyte) cells and PMN at the same extent as LPS. It was previously demonstrated that stimulation of monocytic cells with either LPS or LAMPf led to a series of common downstream signaling events, including the activation of protein tyrosine kinase and of mitogen-activated protein kinase cascades. By using PD-98059 and SB203580, two potent and selective inhibitors of MEK1 (a kinase upstream of ERK1/2) and p38, respectively, we have demonstrated that both ERK1/2 and p38 cascades play a key role in the production of IL-8 by monocytes and PMN stimulated with bacterial fractions.

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[ "Protein" ]

wogonin is a CHEMICAL

23219337_task0

Sentence: Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.

[ "Anti", "-", "tumor", "and", "anti", "-", "metastatic", "actions", "of", "wogonin", "isolated", "from", "Scutellaria", "baicalensis", "roots", "through", "anti", "-", "lymphangiogenesis", "." ]

[ "GENE-Y", "CHEMICAL" ]

wogonin is a CHEMICAL

23219337_task1

Sentence: Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. Instructions: please typing these entity words according to sentence: wogonin Options: CHEMICAL

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.

[ "Anti", "-", "tumor", "and", "anti", "-", "metastatic", "actions", "of", "wogonin", "isolated", "from", "Scutellaria", "baicalensis", "roots", "through", "anti", "-", "lymphangiogenesis", "." ]

[ "GENE-Y", "CHEMICAL" ]

wogonin

23219337_task2

Sentence: Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CHEMICAL", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.

[ "Anti", "-", "tumor", "and", "anti", "-", "metastatic", "actions", "of", "wogonin", "isolated", "from", "Scutellaria", "baicalensis", "roots", "through", "anti", "-", "lymphangiogenesis", "." ]

[ "GENE-Y", "CHEMICAL" ]

tamsulone - FS is a Intervention_Pharmacological, prostatic adenoma is a Participant_Condition, Tamsulone - FS -- is a Intervention_Pharmacological, prostatic adenoma . is a Outcome_Physical, efficacy and safety for management of lower urinary tract symptoms is a Outcome_Other, The efficacy and safety of tamsulone - FS was comparable to those of omnik . is a Outcome_Other

27432_task0

Sentence: [ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Outcome_Other, Intervention_Pharmacological, Outcome_Physical, Participant_Condition

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[ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale .

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[ "Outcome_Other", "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]

tamsulone - FS is a Intervention_Pharmacological, prostatic adenoma is a Participant_Condition, Tamsulone - FS -- is a Intervention_Pharmacological, prostatic adenoma . is a Outcome_Physical, efficacy and safety for management of lower urinary tract symptoms is a Outcome_Other, The efficacy and safety of tamsulone - FS was comparable to those of omnik . is a Outcome_Other

27432_task1

Sentence: [ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale . Instructions: please typing these entity words according to sentence: tamsulone - FS, prostatic adenoma, Tamsulone - FS --, prostatic adenoma ., efficacy and safety for management of lower urinary tract symptoms, The efficacy and safety of tamsulone - FS was comparable to those of omnik . Options: Outcome_Other, Intervention_Pharmacological, Outcome_Physical, Participant_Condition

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[ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale .

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[ "Outcome_Other", "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]

tamsulone - FS, prostatic adenoma, Tamsulone - FS --, prostatic adenoma ., efficacy and safety for management of lower urinary tract symptoms, The efficacy and safety of tamsulone - FS was comparable to those of omnik .

27432_task2

Sentence: [ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale . Instructions: please extract entity words from the input sentence

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[ Pilot results of using tamsulone-FS in patients with prostatic adenoma according to the results of a randomized multicenter comparative trial ] . Tamsulone-FS -- a novel Russian alpha1A/D-adrenoblocker ( Farm-Syntez ) -- was studied in a randomized multicenter comparative trial in patients with prostatic adenoma . Pilot results agreed with other trials published in the literature and demonstrated tamsulone-FS efficacy and safety for management of lower urinary tract symptoms caused by prostatic adenoma . The efficacy and safety of tamsulone-FS was comparable to those of omnik . This drug can be recommended for wide clinical practice in prostatic adenoma . It is registered by Roszdravnadzor ( certificate N LC-000859 of 03.11.2005 ) and allowed for production and sale .

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[ "Outcome_Other", "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological" ]

care is an umlsterm, dance is an umlsterm, joint is an umlsterm, MTP is an umlsterm, dorsiflexion is an umlsterm, great toe is an umlsterm, anatomical is an umlsterm, cadaver is an umlsterm, arthroscopy is an umlsterm, MTP is an umlsterm, University is an umlsterm, procedures is an umlsterm, patients is an umlsterm, operations is an umlsterm, hallux rigidus is an umlsterm, syndrome is an umlsterm, painful joint is an umlsterm, dorsiflexion is an umlsterm, osteochondrosis is an umlsterm, sesamoid bone is an umlsterm, prospective study is an umlsterm, function is an umlsterm, pain is an umlsterm, ability is an umlsterm, sport is an umlsterm, surgery is an umlsterm, patients is an umlsterm, syndromes is an umlsterm, osteochondrosis is an umlsterm, surgery is an umlsterm, hallux rigidus is an umlsterm, sesamoid bone is an umlsterm, pathology is an umlsterm, procedure is an umlsterm, MTP is an umlsterm, Arthroscopy is an umlsterm, MTP is an umlsterm

Arthroskopie.80110283.eng.abstr_task0

Sentence: In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications .

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[ "umlsterm" ]

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Arthroskopie.80110283.eng.abstr_task1

Sentence: In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications . Instructions: please typing these entity words according to sentence: care, dance, joint, MTP, dorsiflexion, great toe, anatomical, cadaver, arthroscopy, MTP, University, procedures, patients, operations, hallux rigidus, syndrome, painful joint, dorsiflexion, osteochondrosis, sesamoid bone, prospective study, function, pain, ability, sport, surgery, patients, syndromes, osteochondrosis, surgery, hallux rigidus, sesamoid bone, pathology, procedure, MTP, Arthroscopy, MTP Options: umlsterm

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In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications .

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[ "umlsterm" ]

care, dance, joint, MTP, dorsiflexion, great toe, anatomical, cadaver, arthroscopy, MTP, University, procedures, patients, operations, hallux rigidus, syndrome, painful joint, dorsiflexion, osteochondrosis, sesamoid bone, prospective study, function, pain, ability, sport, surgery, patients, syndromes, osteochondrosis, surgery, hallux rigidus, sesamoid bone, pathology, procedure, MTP, Arthroscopy, MTP

Arthroskopie.80110283.eng.abstr_task2

Sentence: In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications . Instructions: please extract entity words from the input sentence

[ "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "O", "O", "B-umlsterm", "I-umlsterm", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-umlsterm", "O", "B-umlsterm", "O", "O", "O", "O", "B-umlsterm", "O", "O", "B-umlsterm", "O", "O", "O", "O", "O", "O", "O", "O" ]

In the medical care of a professional dance group we were often confronted with problems of the first metatarsophalangeal joint ( MTP I ) . A painful , limited dorsiflexion of the great toe makes classical ballet performance virtually impossible . After anatomical cadaver studies we introduced arthroscopy of MTP I at the Orthopaedic Department of the Academic Medical Centre of the University of Amsterdam in 1990. By 1992 arthroscopic procedures had been performed in 23 patients . The indications for the operations were : ( 1 ) hallux rigidus ( n = 4 ) , ( 2 ) impingement syndrome ( painful joint with slightly limited dorsiflexion ; n = 11 ) , ( 3 ) osteochondrosis dissecans/loose bodies ( n = 3 ) , and ( 4 ) pathological conditions in sesamoid bone ( n = 5 ) . The result of this prospective study were analysed in respect of function , pain , swelling , ability to work and sport performance . The best results of arthroscopic surgery were seen in patients with impingement syndromes and in osteochondrosis dissecans or loose bodies . The results of arthroscopic surgery of the hallux rigidus and the sesamoid bone pathology were less favourable . The results of our new arthroscopic procedure on MTP I are encouraging . Arthroscopy of the MTP I can be advised for suitable indications .

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[ "umlsterm" ]

human carbonyl reductase 1 is a GENE-Y, CBR1 is a GENE-Y, SDR21C1 is a GENE-Y, Nrf2 is a GENE-Y

23247010_task0

Sentence: Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y

[ "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "O" ]

Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.

[ "Regulation", "of", "human", "carbonyl", "reductase", "1", "(", "CBR1", ",", "SDR21C1", ")", "gene", "by", "transcription", "factor", "Nrf2", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

human carbonyl reductase 1 is a GENE-Y, CBR1 is a GENE-Y, SDR21C1 is a GENE-Y, Nrf2 is a GENE-Y

23247010_task1

Sentence: Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2. Instructions: please typing these entity words according to sentence: human carbonyl reductase 1, CBR1, SDR21C1, Nrf2 Options: GENE-Y

[ "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "O" ]

Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.

[ "Regulation", "of", "human", "carbonyl", "reductase", "1", "(", "CBR1", ",", "SDR21C1", ")", "gene", "by", "transcription", "factor", "Nrf2", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

human carbonyl reductase 1, CBR1, SDR21C1, Nrf2

23247010_task2

Sentence: Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2. Instructions: please extract entity words from the input sentence

[ "O", "O", "B-GENE-Y", "I-GENE-Y", "I-GENE-Y", "I-GENE-Y", "O", "B-GENE-Y", "O", "B-GENE-Y", "O", "O", "O", "O", "O", "B-GENE-Y", "O" ]

Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.

[ "Regulation", "of", "human", "carbonyl", "reductase", "1", "(", "CBR1", ",", "SDR21C1", ")", "gene", "by", "transcription", "factor", "Nrf2", "." ]

[ "GENE-N", "GENE-Y", "CHEMICAL" ]

serotonin receptor is a GENE-N, tricyclic is a CHEMICAL, guanine nucleotide - binding protein - coupled receptor is a GENE-N, serotonin receptors is a GENE-N, serotonin [ 5-hydroxytryptamine ( 5-HT ) ] receptors is a GENE-N, 5-HT2 is a GENE-Y, 5-HT1D is a GENE-Y, 5-HT1C is a GENE-Y, 5-HT1B is a GENE-Y, 5-HT1A is a GENE-Y, ( + ) -[2 - 125I ] iodolysergic acid diethylamide is a CHEMICAL, [ 125I]LSD is a CHEMICAL, 5-HT is a CHEMICAL, [ 125I]LSD is a CHEMICAL, [ 125I]LSD is a CHEMICAL, serotonin receptor is a GENE-N, tricyclic is a CHEMICAL, clozapine is a CHEMICAL, amoxipine is a CHEMICAL, amitriptyline is a CHEMICAL, serotonin is a CHEMICAL, adenylyl cyclase is a GENE-N, serotonin receptor is a GENE-N, tricyclic is a CHEMICAL

20794_task0

Sentence: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: GENE-Y, GENE-N, CHEMICAL

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Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems.

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

serotonin receptor is a GENE-N, tricyclic is a CHEMICAL, guanine nucleotide - binding protein - coupled receptor is a GENE-N, serotonin receptors is a GENE-N, serotonin [ 5-hydroxytryptamine ( 5-HT ) ] receptors is a GENE-N, 5-HT2 is a GENE-Y, 5-HT1D is a GENE-Y, 5-HT1C is a GENE-Y, 5-HT1B is a GENE-Y, 5-HT1A is a GENE-Y, ( + ) -[2 - 125I ] iodolysergic acid diethylamide is a CHEMICAL, [ 125I]LSD is a CHEMICAL, 5-HT is a CHEMICAL, [ 125I]LSD is a CHEMICAL, [ 125I]LSD is a CHEMICAL, serotonin receptor is a GENE-N, tricyclic is a CHEMICAL, clozapine is a CHEMICAL, amoxipine is a CHEMICAL, amitriptyline is a CHEMICAL, serotonin is a CHEMICAL, adenylyl cyclase is a GENE-N, serotonin receptor is a GENE-N, tricyclic is a CHEMICAL

20794_task1

Sentence: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems. Instructions: please typing these entity words according to sentence: serotonin receptor, tricyclic, guanine nucleotide - binding protein - coupled receptor, serotonin receptors, serotonin [ 5-hydroxytryptamine ( 5-HT ) ] receptors, 5-HT2, 5-HT1D, 5-HT1C, 5-HT1B, 5-HT1A, ( + ) -[2 - 125I ] iodolysergic acid diethylamide, [ 125I]LSD, 5-HT, [ 125I]LSD, [ 125I]LSD, serotonin receptor, tricyclic, clozapine, amoxipine, amitriptyline, serotonin, adenylyl cyclase, serotonin receptor, tricyclic Options: GENE-Y, GENE-N, CHEMICAL

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Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems.

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

serotonin receptor, tricyclic, guanine nucleotide - binding protein - coupled receptor, serotonin receptors, serotonin [ 5-hydroxytryptamine ( 5-HT ) ] receptors, 5-HT2, 5-HT1D, 5-HT1C, 5-HT1B, 5-HT1A, ( + ) -[2 - 125I ] iodolysergic acid diethylamide, [ 125I]LSD, 5-HT, [ 125I]LSD, [ 125I]LSD, serotonin receptor, tricyclic, clozapine, amoxipine, amitriptyline, serotonin, adenylyl cyclase, serotonin receptor, tricyclic

20794_task2

Sentence: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems. Instructions: please extract entity words from the input sentence

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Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. We have used the polymerase chain reaction technique to selectively amplify a guanine nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that exhibits high homology to previously cloned serotonin receptors. Sequencing of a full length clone isolated from a rat striatal cDNA library revealed an open reading frame of 1311 base pairs, encoding a 437-residue protein with seven hydrophobic regions. Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Northern blots revealed a approximately 4.2-kilobase transcript localized in various brain regions, with the following rank order of abundance: striatum >> olfactory tubercle > cerebral cortex > hippocampus. Expression of this clone in COS-7 cells resulted in the appearance of high affinity, saturable binding of (+)-[2-125I] iodolysergic acid diethylamide ([125I]LSD) with a Kd of 1.26 nM. Among endogenous biogenic amines, only 5-HT completely inhibited [125I]LSD binding (Ki = 150 nM). The inhibition of [125I]LSD binding by other serotonergic agonists and antagonists revealed a pharmacological profile that does not correlate with that of any previously described serotonin receptor subtype. In addition, this receptor exhibits high affinity for a number of tricyclic antipsychotic and antidepressant drugs, including clozapine, amoxipine, and amitriptyline. In HEK-293 cells stably transfected with this receptor, serotonin elicits a potent stimulation of adenylyl cyclase activity, which is blocked by antipsychotic and antidepressant drugs. The distinct structural and pharmacological properties of this receptor site indicate that it represents a completely novel subtype of serotonin receptor. Based on its affinity for tricyclic psychotropic drugs and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems.

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[ "GENE-N", "CHEMICAL", "GENE-Y" ]

HMSN is an umlsterm, Menschen is an umlsterm, Mutationen is an umlsterm, Genen is an umlsterm, Gene is an umlsterm, Proteinprodukte is an umlsterm, peripheren Nervensystems is an umlsterm, Kommunikation is an umlsterm, Diagnose is an umlsterm, praenatale Diagnostik is an umlsterm, Prognose is an umlsterm, Pathophysiologie is an umlsterm

DerNervenarzt.60670987.ger.abstr_task0

Sentence: Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten .

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[ "umlsterm" ]

HMSN is an umlsterm, Menschen is an umlsterm, Mutationen is an umlsterm, Genen is an umlsterm, Gene is an umlsterm, Proteinprodukte is an umlsterm, peripheren Nervensystems is an umlsterm, Kommunikation is an umlsterm, Diagnose is an umlsterm, praenatale Diagnostik is an umlsterm, Prognose is an umlsterm, Pathophysiologie is an umlsterm

DerNervenarzt.60670987.ger.abstr_task1

Sentence: Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten . Instructions: please typing these entity words according to sentence: HMSN, Menschen, Mutationen, Genen, Gene, Proteinprodukte, peripheren Nervensystems, Kommunikation, Diagnose, praenatale Diagnostik, Prognose, Pathophysiologie Options: umlsterm

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Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten .

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[ "umlsterm" ]

HMSN, Menschen, Mutationen, Genen, Gene, Proteinprodukte, peripheren Nervensystems, Kommunikation, Diagnose, praenatale Diagnostik, Prognose, Pathophysiologie

DerNervenarzt.60670987.ger.abstr_task2

Sentence: Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten . Instructions: please extract entity words from the input sentence

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Hereditaere motorische und sensible Neuropathien ( HMSN ) zaehlen zu den haeufigsten vererbbaren Erkrankungen des Menschen . In den letzten Jahren wurden Mutationen in verschiedenen Genen gefunden , die als ursaechlich fuer die Entstehung der hereditaeren Neuropathien angesehen werden muessen . Es handelt sich um Gene , deren Proteinprodukte zum einen Bausteine des Myelins des peripheren Nervensystems darstellen und zum anderen ein Gap-junction-Protein bilden , das die intra- und interzellulare Kommunikation ermoeglicht . Es ist nicht bekannt , ueber welche Zwischenschritte die einzelnen genetischen Veraenderungen zum jeweiligen Krankheitsphaenotyp fuehren . Die Pathogenese ist also noch nicht in allen Einzelheiten aufgeklaert . Die molekulargenetischen Befunde erlauben in den weitaus meisten Faellen eine exakte Diagnose auch ohne Zuhilfenahme histologischer Untersuchungen . Ebenso ist eine praenatale Diagnostik moeglich , deren Wertigkeit wegen der erheblichen Varianz der spaeteren Prognose des Krankheitsphaenotyps jedoch gering ist . Durch die Aufklaerung der Pathophysiologie sind neue individualtherapeutisch einsetzbare , effektive Behandlungsmoeglichkeiten , zu erwarten .

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[ "umlsterm" ]

Collaborative Initial Glaucoma Treatment Study is a Participant_Condition, visual field ( VF ) progression is a Outcome_Physical, 607 subjects with newly diagnosed open - angle glaucoma is a Participant_Condition, treated with either medication or trabeculectomy is a Intervention_Pharmacological, treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye - specific target pressure . Visual field progression was analyzed using repeated measures models is a Intervention_Physical, Visual field progression , measured by Humphrey 24 - 2 full - threshold testing and assessed by the change in the mean deviation ( MD ) is a Outcome_Physical, an indicator of substantial worsening of the VF is a Outcome_Physical, worsening ( > or =3 dB ) of MD is a Outcome_Physical, initial medicine is a Intervention_Pharmacological, VF loss is a Outcome_Physical, Initial surgery is a Intervention_Surgical, VF progression is a Outcome_Physical, subjects with advanced VF loss at baseline is a Participant_Condition, lowering of IOP is a Outcome_Physical, subjects with more advanced VF loss at presentation is a Participant_Condition, patients with diabetes is a Participant_Condition

37991_task0

Sentence: Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Intervention_Surgical

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Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article .

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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological", "Intervention_Surgical" ]

Collaborative Initial Glaucoma Treatment Study is a Participant_Condition, visual field ( VF ) progression is a Outcome_Physical, 607 subjects with newly diagnosed open - angle glaucoma is a Participant_Condition, treated with either medication or trabeculectomy is a Intervention_Pharmacological, treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye - specific target pressure . Visual field progression was analyzed using repeated measures models is a Intervention_Physical, Visual field progression , measured by Humphrey 24 - 2 full - threshold testing and assessed by the change in the mean deviation ( MD ) is a Outcome_Physical, an indicator of substantial worsening of the VF is a Outcome_Physical, worsening ( > or =3 dB ) of MD is a Outcome_Physical, initial medicine is a Intervention_Pharmacological, VF loss is a Outcome_Physical, Initial surgery is a Intervention_Surgical, VF progression is a Outcome_Physical, subjects with advanced VF loss at baseline is a Participant_Condition, lowering of IOP is a Outcome_Physical, subjects with more advanced VF loss at presentation is a Participant_Condition, patients with diabetes is a Participant_Condition

37991_task1

Sentence: Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article . Instructions: please typing these entity words according to sentence: Collaborative Initial Glaucoma Treatment Study, visual field ( VF ) progression, 607 subjects with newly diagnosed open - angle glaucoma, treated with either medication or trabeculectomy, treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye - specific target pressure . Visual field progression was analyzed using repeated measures models, Visual field progression , measured by Humphrey 24 - 2 full - threshold testing and assessed by the change in the mean deviation ( MD ), an indicator of substantial worsening of the VF, worsening ( > or =3 dB ) of MD, initial medicine, VF loss, Initial surgery, VF progression, subjects with advanced VF loss at baseline, lowering of IOP, subjects with more advanced VF loss at presentation, patients with diabetes Options: Intervention_Pharmacological, Intervention_Physical, Participant_Condition, Outcome_Physical, Intervention_Surgical

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Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article .

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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological", "Intervention_Surgical" ]

Collaborative Initial Glaucoma Treatment Study, visual field ( VF ) progression, 607 subjects with newly diagnosed open - angle glaucoma, treated with either medication or trabeculectomy, treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye - specific target pressure . Visual field progression was analyzed using repeated measures models, Visual field progression , measured by Humphrey 24 - 2 full - threshold testing and assessed by the change in the mean deviation ( MD ), an indicator of substantial worsening of the VF, worsening ( > or =3 dB ) of MD, initial medicine, VF loss, Initial surgery, VF progression, subjects with advanced VF loss at baseline, lowering of IOP, subjects with more advanced VF loss at presentation, patients with diabetes

37991_task2

Sentence: Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article . Instructions: please extract entity words from the input sentence

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Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors . PURPOSE To evaluate factors associated with visual field ( VF ) progression , using all available follow-up through 9 years after treatment initiation , in the Collaborative Initial Glaucoma Treatment Study ( CIGTS ) . DESIGN Longitudinal follow-up of participants enrolled in a randomized clinical trial . PARTICIPANTS Six hundred seven newly diagnosed glaucoma patients . METHODS In a randomized clinical trial , 607 subjects with newly diagnosed open-angle glaucoma initially were treated with either medication or trabeculectomy . After treatment initiation and early follow-up , subjects were evaluated clinically at 6-month intervals . Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure ( IOP ) to a level at or below a predetermined , eye-specific target pressure . Visual field progression was analyzed using repeated measures models . MAIN OUTCOME MEASURES Visual field progression , measured by Humphrey 24-2 full-threshold testing and assessed by the change in the mean deviation ( MD ) , and an indicator of substantial worsening of the VF ( MD decrease of > or =3 dB from baseline ) , assessed at each follow-up visit . RESULTS Follow-up indicated minimal change from baseline in each initial treatment group 's average MD . However , at the 8-year follow-up examination , substantial worsening ( > or =3 dB ) of MD from baseline was found in 21.3 % and 25.5 % of the initial surgery and initial medicine groups , respectively . The effect of initial treatment on subsequent VF loss was modified by time ( P < 0.0001 ) , baseline MD ( P = 0.03 ) , and diabetes ( P = 0.01 ) . Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline , whereas subjects with diabetes had more VF loss over time if treated initially with surgery . CONCLUSIONS The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups . Progression in VF loss was seen in a subset , increasing to more than 20 % of the subjects . The findings regarding initial surgery being beneficial for subjects with more advanced VF loss at presentation , but detrimental for patients with diabetes , are noteworthy and warrant independent confirmation . FINANCIAL DISCLOSURE ( S ) The author ( s ) have no proprietary or commercial interest in any materials discussed in this article .

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[ "Intervention_Physical", "Outcome_Physical", "Participant_Condition", "Intervention_Pharmacological", "Intervention_Surgical" ]

Tat is a Protein, tat - I is a Protein, Tat - I is a Protein, p49(100 ) is a Protein, p65 is a Protein, Tat - I is a Protein, CAT is a Protein, p105 is a Protein, rel is a Protein, p65 is a Protein, c - rel is a Protein, p49(100 ) is a Protein, p65 is a Protein, tat - I is a Protein

267_task0

Sentence: Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Protein

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Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA.

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[ "Protein" ]

Tat is a Protein, tat - I is a Protein, Tat - I is a Protein, p49(100 ) is a Protein, p65 is a Protein, Tat - I is a Protein, CAT is a Protein, p105 is a Protein, rel is a Protein, p65 is a Protein, c - rel is a Protein, p49(100 ) is a Protein, p65 is a Protein, tat - I is a Protein

267_task1

Sentence: Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA. Instructions: please typing these entity words according to sentence: Tat, tat - I, Tat - I, p49(100 ), p65, Tat - I, CAT, p105, rel, p65, c - rel, p49(100 ), p65, tat - I Options: Protein

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Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA.

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[ "Protein" ]

Tat, tat - I, Tat - I, p49(100 ), p65, Tat - I, CAT, p105, rel, p65, c - rel, p49(100 ), p65, tat - I

267_task2

Sentence: Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA. Instructions: please extract entity words from the input sentence

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Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription. NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA.

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[ "Protein" ]

atopic dermatitis is an umlsterm, face is an umlsterm, therapy is an umlsterm, therapeutic is an umlsterm, efficiency is an umlsterm, cold is an umlsterm, light is an umlsterm, treatment is an umlsterm, phototherapy is an umlsterm, patients is an umlsterm, cold is an umlsterm, light is an umlsterm, patients is an umlsterm, patients is an umlsterm, therapy is an umlsterm, treatment protocol is an umlsterm, skin is an umlsterm, patients is an umlsterm, period is an umlsterm, skin is an umlsterm, cold is an umlsterm, light is an umlsterm, patients is an umlsterm, cold is an umlsterm, light is an umlsterm, therapy is an umlsterm, patients is an umlsterm, therapy is an umlsterm, patients is an umlsterm, Plasma is an umlsterm, eosinophil cationic protein is an umlsterm, interleukin-2 is an umlsterm, phototherapy is an umlsterm, therapy is an umlsterm, phototherapy is an umlsterm, cold is an umlsterm, light is an umlsterm, phototherapy is an umlsterm, skin is an umlsterm, blood is an umlsterm, Laser is an umlsterm, sweat is an umlsterm, production is an umlsterm, patient is an umlsterm, visual analog scale is an umlsterm

DerHautarzt.90500027.eng.abstr_task0

Sentence: Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) .

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[ "umlsterm" ]

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DerHautarzt.90500027.eng.abstr_task1

Sentence: Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) . Instructions: please typing these entity words according to sentence: atopic dermatitis, face, therapy, therapeutic, efficiency, cold, light, treatment, phototherapy, patients, cold, light, patients, patients, therapy, treatment protocol, skin, patients, period, skin, cold, light, patients, cold, light, therapy, patients, therapy, patients, Plasma, eosinophil cationic protein, interleukin-2, phototherapy, therapy, phototherapy, cold, light, phototherapy, skin, blood, Laser, sweat, production, patient, visual analog scale Options: umlsterm

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Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) .

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[ "umlsterm" ]

atopic dermatitis, face, therapy, therapeutic, efficiency, cold, light, treatment, phototherapy, patients, cold, light, patients, patients, therapy, treatment protocol, skin, patients, period, skin, cold, light, patients, cold, light, therapy, patients, therapy, patients, Plasma, eosinophil cationic protein, interleukin-2, phototherapy, therapy, phototherapy, cold, light, phototherapy, skin, blood, Laser, sweat, production, patient, visual analog scale

DerHautarzt.90500027.eng.abstr_task2

Sentence: Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) . Instructions: please extract entity words from the input sentence

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Severe atopic dermatitis , especially when involving the face , does not respond well to conventional therapy . In the present prospective randomized trial , we compared therapeutic efficiency of medium-dose UVA1, medium-dose cold light UVA1 ( 15 treatment courses with 50 J/cm2 each ) and combined UVA-UVB phototherapy . Four ( 13,3% ) of 30 UVA1 treated patients , one ( 3,4% ) of 30 UVA1 cold light treated patients and three ( 30% ) of 10 patients treated with combined UVA-UVB discontinued therapy course before finishing treatment protocol because skin status did not improve or even deteriorated . In the other patients treated over a period of three weeks , skin status improved significantly or even cleared completely in 80,8% of UVA1 treated and in 89,7% of UVA1 cold light treated patients resulting in a significant decrease of the SCORAD-Score ( UVA1 group from 68,6 +/- SD 10,9 to 29,8 +/- SD 7,1 and UVA1 cold light group from 72,5 +/- SD 13,4 to 23,8 +/- SD 11,6 ; p 0,05 each ) . In the UVA-UVB treated group , the SCORAD-Score also decreased ( from 71,0 +/- SD 9,4 to 41,6 +/- 10,5 ) , but significantly less than in both UVA1 treated groups ( p 0,05 each ) . Four weeks after completing therapy UVA1 treated patients showed a prolonged therapy benefit as compared to UVA-UVB treated patients . Plasma levels of eosinophil cationic protein and soluble interleukin-2 receptor significantly decreased under UVA1 phototherapy but not under UVA-UVB therapy . Compared to conventional UVA1 phototherapy , UVA1 cold light phototherapy showed advantages due to the absence of potentially proinflammatory effects based on temperature-induced increase of skin blood flow ( quantified by Laser doppler scanning ) and increased sweat production ( determined by the patient using a visual analog scale ) .

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[ "umlsterm" ]

question - asking is a Intervention_Educational, robot intervention is a Intervention_Psychological, human - trainer intervention is a Intervention_Educational, applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA - based intervention conducted by a human trainer is a Intervention_Educational, self - initiated questions is a Outcome_Mental, interventions conducted by a is a Intervention_Psychological, and a is a Intervention_Psychological

59091_task0

Sentence: Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Psychological, Intervention_Educational, Outcome_Mental

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Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed .

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[ "Intervention_Educational", "Intervention_Psychological", "Outcome_Mental" ]

question - asking is a Intervention_Educational, robot intervention is a Intervention_Psychological, human - trainer intervention is a Intervention_Educational, applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA - based intervention conducted by a human trainer is a Intervention_Educational, self - initiated questions is a Outcome_Mental, interventions conducted by a is a Intervention_Psychological, and a is a Intervention_Psychological

59091_task1

Sentence: Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed . Instructions: please typing these entity words according to sentence: question - asking, robot intervention, human - trainer intervention, applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA - based intervention conducted by a human trainer, self - initiated questions, interventions conducted by a, and a Options: Intervention_Psychological, Intervention_Educational, Outcome_Mental

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Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed .

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[ "Intervention_Educational", "Intervention_Psychological", "Outcome_Mental" ]

question - asking, robot intervention, human - trainer intervention, applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA - based intervention conducted by a human trainer, self - initiated questions, interventions conducted by a, and a

59091_task2

Sentence: Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed . Instructions: please extract entity words from the input sentence

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Promoting question-asking in school-aged children with autism spectrum disorders : effectiveness of a robot intervention compared to a human-trainer intervention . OBJECTIVE The purpose of the present study was to investigate the effectiveness of an applied behaviour analysis ( ABA ) -based intervention conducted by a robot compared to an ABA-based intervention conducted by a human trainer in promoting self-initiated questions in children with autism spectrum disorder ( ASD ) . METHODS Data were collected in a combined crossover multiple baseline design across participants . Six children were randomly assigned to two experimental groups . RESULTS Results revealed that the number of self-initiated questions for both experimental groups increased between baseline and the first intervention and was maintained during follow-up . The high number of self-initiated questions during follow-up indicates that both groups maintained this skill . CONCLUSIONS The interventions conducted by a robot and a human trainer were both effective in promoting self-initiated questions in children with ASD . No conclusion with regard to the differential effectiveness of both interventions could be drawn . Implications of the results and directions for future research are discussed .

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[ "Intervention_Educational", "Intervention_Psychological", "Outcome_Mental" ]

Non - Hodgkin - Lymphom is an umlsterm, Lymphom is an umlsterm, Verhalten is an umlsterm, Prognose is an umlsterm, Behandlung is an umlsterm, Lymphomen is an umlsterm, Lymphome is an umlsterm, radiologische is an umlsterm

DerRadiologe.70370035.ger.abstr_task0

Sentence: Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten .

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[ "umlsterm" ]

Non - Hodgkin - Lymphom is an umlsterm, Lymphom is an umlsterm, Verhalten is an umlsterm, Prognose is an umlsterm, Behandlung is an umlsterm, Lymphomen is an umlsterm, Lymphome is an umlsterm, radiologische is an umlsterm

DerRadiologe.70370035.ger.abstr_task1

Sentence: Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten . Instructions: please typing these entity words according to sentence: Non - Hodgkin - Lymphom, Lymphom, Verhalten, Prognose, Behandlung, Lymphomen, Lymphome, radiologische Options: umlsterm

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Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten .

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[ "umlsterm" ]

Non - Hodgkin - Lymphom, Lymphom, Verhalten, Prognose, Behandlung, Lymphomen, Lymphome, radiologische

DerRadiologe.70370035.ger.abstr_task2

Sentence: Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten . Instructions: please extract entity words from the input sentence

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Der Gastrointestinaltrakt ist das Organ , das am haeufigsten von einem extranodalen Non-Hodgkin-Lymphom befallen wird . Das primaere gastrointestinale Lymphom ( PGIL ) stellt ein eigenstaendiges Krankheitsbild dar , da das biologische Verhalten , die Prognose und die Behandlung sich von den nodalen Lymphomen unterscheiden . Bildgebende Verfahren sind wichtig bei der Suche und bei der Stadieneinteilung des PGIL . Die gastrointestinalen Lymphome zeigen eine Vielfalt von pathohistologischen Erscheinungsbildern und ein weites Spektrum bei der Bildgebung . Die Zunahme der PGIL erfordert Kenntnisse ueber das klinische und radiologische Bild und die therapeutischen Moeglichkeiten .

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[ "umlsterm" ]

III is a Protein, III is a Protein, lysyl is a Entity, hydroxylysine is a Entity

526_task0

Sentence: Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Entity, Protein

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Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell.

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[ "Entity", "Protein" ]

III is a Protein, III is a Protein, lysyl is a Entity, hydroxylysine is a Entity

526_task1

Sentence: Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell. Instructions: please typing these entity words according to sentence: III, III, lysyl, hydroxylysine Options: Entity, Protein

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Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell.

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[ "Entity", "Protein" ]

III, III, lysyl, hydroxylysine

526_task2

Sentence: Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell. Instructions: please extract entity words from the input sentence

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Regulation of collagen post-translational modification in transformed human and chick-embryo cells. Changes in the regulation of collagen post-translational modification in transformed cells were studied in three established human sarcoma cell lines and in chick-embryo fibroblasts freshly transformed by Rous sarcoma virus. The collagens synthesized by all but one of these and by all the control human and chick-embryo cell lines were almost exclusively of types I and/or III. The relative rate of collagen synthesis and the amounts of prolyl hydroxylase activity and immunoreactive protein were markedly low in all the transformed human cell lines. The other enzymes studied, lysyl hydroxylase, hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase, never showed as large a decrease in activity as did prolyl hydroxylase, suggesting a more efficient regulation of the last enzyme than of the three others. The chick-embryo fibroblasts freshly transformed by Rous sarcoma virus differed from the human sarcoma cells in that prolyl hydroxylase activity was distinctly increased, whereas the decreases in immunoreactive prolyl hydroxylase protein and the three other enzyme activities were very similar to those in the simian-virus-40-transformed human fibroblasts. It seems possible that this increased prolyl hydroxylase activity is only a temporary phenomenon occurring shortly after the transformation, and may be followed by a decrease in activity later. The newly synthesized collagens of all the transformed cells that produced almost exclusively collagen types I and/or III had high extents of lysyl hydroxylation, and there was also an increase in the ratio of glycosylated to non-glycosylated hydroxylysine. The data suggest that one critical factor affecting modification is the rate of collagen synthesis, which affects the ratio of enzyme to substrate in the cell.

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[ "Entity", "Protein" ]

Ketamin is an umlsterm, intravenoesen Anaesthetika is an umlsterm, Anaesthesie is an umlsterm, Ketamin is an umlsterm, Ketamin is an umlsterm, ligandengesteuerter is an umlsterm, Ionenkanaele is an umlsterm, Rolle is an umlsterm, Analgesie is an umlsterm, Amnesie is an umlsterm, Anaesthesie is an umlsterm, -Opiatrezeptoren is an umlsterm, L - Typ - Kalziumkanaele is an umlsterm, Ionenkanaele is an umlsterm, Rolle is an umlsterm, Ketamin is an umlsterm

DerAnaesthesist.7046s008.ger.abstr_task0

Sentence: Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar .

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[ "umlsterm" ]

Ketamin is an umlsterm, intravenoesen Anaesthetika is an umlsterm, Anaesthesie is an umlsterm, Ketamin is an umlsterm, Ketamin is an umlsterm, ligandengesteuerter is an umlsterm, Ionenkanaele is an umlsterm, Rolle is an umlsterm, Analgesie is an umlsterm, Amnesie is an umlsterm, Anaesthesie is an umlsterm, -Opiatrezeptoren is an umlsterm, L - Typ - Kalziumkanaele is an umlsterm, Ionenkanaele is an umlsterm, Rolle is an umlsterm, Ketamin is an umlsterm

DerAnaesthesist.7046s008.ger.abstr_task1

Sentence: Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar . Instructions: please typing these entity words according to sentence: Ketamin, intravenoesen Anaesthetika, Anaesthesie, Ketamin, Ketamin, ligandengesteuerter, Ionenkanaele, Rolle, Analgesie, Amnesie, Anaesthesie, -Opiatrezeptoren, L - Typ - Kalziumkanaele, Ionenkanaele, Rolle, Ketamin Options: umlsterm

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Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar .

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[ "umlsterm" ]

Ketamin, intravenoesen Anaesthetika, Anaesthesie, Ketamin, Ketamin, ligandengesteuerter, Ionenkanaele, Rolle, Analgesie, Amnesie, Anaesthesie, -Opiatrezeptoren, L - Typ - Kalziumkanaele, Ionenkanaele, Rolle, Ketamin

DerAnaesthesist.7046s008.ger.abstr_task2

Sentence: Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar . Instructions: please extract entity words from the input sentence

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Das Phenzyklidin-Derivat Ketamin nimmt auch 30 Jahre nach seiner klinischen Einfuehrung eine Sonderstellung unter intravenoesen Anaesthetika ein . Seiner besonderen Wirkung wurde auch mit dem Begriff der dissoziativen Anaesthesie " " Rechnung getragen , deren neuropharmakologische Grundlage jedoch nicht ausreichend geklaert ist . Neue methodische Moeglichkeiten und die Verfuegbarkeit der reinen Ketaminenantiomere haben jedoch in den letzten Jahren Erkenntnisse gewinnen lassen , die in dieser Uebersicht mit ihrer Relevanz fuer die analgetische , anaesthetische und neuroprotektive Wirkung von Ketamin bewertet werden sollen . Ketamin scheint sehr spezifisch mit einer kleinen Gruppe ligandengesteuerter Ionenkanaele ( Klasse-1-Rezeptoren) zu interagieren , wobei an der zentralen Rolle des NMDA-Rezeptorkanals fuer Analgesie , Amnesie , Anaesthesie und psychotomimetische Wirkungen kein Zweifel besteht . Zusaetzlich tragen -Opiatrezeptoren monoaminerge und cholinerge Wirkungen , bei . Neu ist die klinisch bedeutsame Interaktion mit muskarinischen Rezeptoren und non-NMDA-Rezeptorkanaelen . Mit Ausnahme der L-Typ-Kalziumkanaele spielen spannungsgesteuerte Ionenkanaele , soweit bisher untersucht , fuer klinische Wirkungen nur eine untergeordnete Rolle . Die Beeinflussung von L-Typ-Kalziumkanaelen , non-NMDA und NMDA-Rezeptorkanaelen sowie des NO-cGMP-Systems stellen ausserdem eine rationale Basis fuer die neuroprotektive Wirksamkeit von Ketamin dar .

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[ "umlsterm" ]

lectins is a protein, ammonium sulphate is a compound

DS.d981_task0

Sentence: The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin. Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: compound, protein

[ "O", "B-protein", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin.

[ "The", "lectins", "were", "isolated", "by", "ammonium", "sulphate", "treatment", "of", "crude", "extracts", "followed", "by", "chromatography", "on", "chitin", "." ]

[ "compound", "protein" ]

lectins is a protein, ammonium sulphate is a compound

DS.d981_task1

Sentence: The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin. Instructions: please typing these entity words according to sentence: lectins, ammonium sulphate Options: compound, protein

[ "O", "B-protein", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin.

[ "The", "lectins", "were", "isolated", "by", "ammonium", "sulphate", "treatment", "of", "crude", "extracts", "followed", "by", "chromatography", "on", "chitin", "." ]

[ "compound", "protein" ]

lectins, ammonium sulphate

DS.d981_task2

Sentence: The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin. Instructions: please extract entity words from the input sentence

[ "O", "B-protein", "O", "O", "O", "B-compound", "I-compound", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin.

[ "The", "lectins", "were", "isolated", "by", "ammonium", "sulphate", "treatment", "of", "crude", "extracts", "followed", "by", "chromatography", "on", "chitin", "." ]

[ "compound", "protein" ]

malignant is an umlsterm, tumors is an umlsterm, carcinosarcomas is an umlsterm, neoplasm is an umlsterm, probability is an umlsterm, uterus is an umlsterm, old is an umlsterm, female is an umlsterm, patient is an umlsterm, Histopathological is an umlsterm, evaluation is an umlsterm, biopsy is an umlsterm, malignancy is an umlsterm, time is an umlsterm, enlargement is an umlsterm, histopathological is an umlsterm, evaluation is an umlsterm, malignant is an umlsterm, tumor is an umlsterm, carcinosarcoma is an umlsterm, patient is an umlsterm, radiation is an umlsterm, disease is an umlsterm

DerUrologeA.80370382.eng.abstr_task0

Sentence: In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: umlsterm

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In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease .

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[ "umlsterm" ]

malignant is an umlsterm, tumors is an umlsterm, carcinosarcomas is an umlsterm, neoplasm is an umlsterm, probability is an umlsterm, uterus is an umlsterm, old is an umlsterm, female is an umlsterm, patient is an umlsterm, Histopathological is an umlsterm, evaluation is an umlsterm, biopsy is an umlsterm, malignancy is an umlsterm, time is an umlsterm, enlargement is an umlsterm, histopathological is an umlsterm, evaluation is an umlsterm, malignant is an umlsterm, tumor is an umlsterm, carcinosarcoma is an umlsterm, patient is an umlsterm, radiation is an umlsterm, disease is an umlsterm

DerUrologeA.80370382.eng.abstr_task1

Sentence: In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease . Instructions: please typing these entity words according to sentence: malignant, tumors, carcinosarcomas, neoplasm, probability, uterus, old, female, patient, Histopathological, evaluation, biopsy, malignancy, time, enlargement, histopathological, evaluation, malignant, tumor, carcinosarcoma, patient, radiation, disease Options: umlsterm

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In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease .

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[ "umlsterm" ]

malignant, tumors, carcinosarcomas, neoplasm, probability, uterus, old, female, patient, Histopathological, evaluation, biopsy, malignancy, time, enlargement, histopathological, evaluation, malignant, tumor, carcinosarcoma, patient, radiation, disease

DerUrologeA.80370382.eng.abstr_task2

Sentence: In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease . Instructions: please extract entity words from the input sentence

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In total malignant mixed tumors ( carcinosarcomas ) represent a very rare gynecological neoplasm . In accordance with the embryological genesis primary localizations are with descending probability the uterus , the ovarians and finally the tubes . We report on a 55 year old female patient , with a paraurethral mass , which was primarily diagnosed in 1994. Histopathological evaluation of a transvaginal biopsy did not demonstrate evidence of malignancy at that time . After painful enlargement the paraurethral mass was resected surgically and histopathological evaluation revealed a primary paraurethral malignant mixed tumor ( carcinosarcoma ) . Postoperatively , the patient underwent percutaneous ( 46,4 Gy ) and intracavitarv ( 2 x 6 Gy ) radiation . Twelve months postoperatively there is no evidence of disease .

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[ "umlsterm" ]

migraine is a Outcome_Mental, flunarizine is a Intervention_Pharmacological, acetylsalicylic acid is a Intervention_Pharmacological, 30 is a Participant_Sample-size, children between 7 and 17 is a Participant_Age, common or classical migraine is a Participant_Condition, blocker Flunarizine ( Sibelium ) is a Intervention_Pharmacological, Acetylsalicylic acid ( ASS ) is a Intervention_Pharmacological, attack frequency and duration is a Outcome_Physical, reduction of attack frequency or symptoms is a Outcome_Physical, Migraine frequency is a Outcome_Other, Duration is a Outcome_Other, slight body weight gain is a Outcome_Adverse-effects, abdominal pain is a Outcome_Adverse-effects, childhood migraine . is a Participant_Condition

75521_task0

Sentence: [ Prevention of migraine with flunarizine and acetylsalicylic acid . A double-blind study ] . UNLABELLED 30 children between 7 and 17 years suffering from at least 2 attacks/month of common or classical migraine since more than 1 year were studied . After clinical exclusion of symptomatic headache 4 weeks were documented by means of a migraine diary . Prophylaxis with Calcium entry blocker Flunarizine ( Sibelium ) or Thromboxane A inhibitor Acetylsalicylic acid ( ASS ) was carried out in a double blind design for 3 months . Medication was given as one dosage in the evening : 2-5 mg/kg KG ASS or 5-10 mg Flunarizine . Documented attack frequency and duration were controlled at monthly physical examinations . Final results showed no differences in significant reduction of attack frequency or symptoms between both different therapeutic principals . 72.4 % ( ASS 73.3 % ; Flunarizine 71.4 % ) of patients were attack-free or had at least a 50 % reduction . Migraine frequency of initially 7-8 was reduced to 1-2 attacks/month . Duration remained constant in both groups ( 1-3 h ) . Side effects were slight body weight gain or abdominal pain after intake , prophylaxis had not to be interrupted therefore . Longtime prognosis is not yet possible because the time of observation is too short so far . CONCLUSION Both substances are definitely useful and have few side effects in childhood migraine . If the response to one is insufficient the other substance should be tried . Instructions: please extract entities and their types from the input sentence, all entity types are in options Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Condition, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental

[ "O", "O", "O", "B-Outcome_Mental", "O", "B-Intervention_Pharmacological", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Sample-size", "B-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "I-Participant_Age", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "B-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "I-Intervention_Pharmacological", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "I-Outcome_Physical", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "I-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Other", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "B-Outcome_Adverse-effects", "I-Outcome_Adverse-effects", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-Participant_Condition", "I-Participant_Condition", "I-Participant_Condition", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ]

[ Prevention of migraine with flunarizine and acetylsalicylic acid . A double-blind study ] . UNLABELLED 30 children between 7 and 17 years suffering from at least 2 attacks/month of common or classical migraine since more than 1 year were studied . After clinical exclusion of symptomatic headache 4 weeks were documented by means of a migraine diary . Prophylaxis with Calcium entry blocker Flunarizine ( Sibelium ) or Thromboxane A inhibitor Acetylsalicylic acid ( ASS ) was carried out in a double blind design for 3 months . Medication was given as one dosage in the evening : 2-5 mg/kg KG ASS or 5-10 mg Flunarizine . Documented attack frequency and duration were controlled at monthly physical examinations . Final results showed no differences in significant reduction of attack frequency or symptoms between both different therapeutic principals . 72.4 % ( ASS 73.3 % ; Flunarizine 71.4 % ) of patients were attack-free or had at least a 50 % reduction . Migraine frequency of initially 7-8 was reduced to 1-2 attacks/month . Duration remained constant in both groups ( 1-3 h ) . Side effects were slight body weight gain or abdominal pain after intake , prophylaxis had not to be interrupted therefore . Longtime prognosis is not yet possible because the time of observation is too short so far . CONCLUSION Both substances are definitely useful and have few side effects in childhood migraine . If the response to one is insufficient the other substance should be tried .

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[ "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition", "Participant_Age", "Outcome_Adverse-effects", "Outcome_Other", "Outcome_Mental", "Participant_Sample-size" ]

migraine is a Outcome_Mental, flunarizine is a Intervention_Pharmacological, acetylsalicylic acid is a Intervention_Pharmacological, 30 is a Participant_Sample-size, children between 7 and 17 is a Participant_Age, common or classical migraine is a Participant_Condition, blocker Flunarizine ( Sibelium ) is a Intervention_Pharmacological, Acetylsalicylic acid ( ASS ) is a Intervention_Pharmacological, attack frequency and duration is a Outcome_Physical, reduction of attack frequency or symptoms is a Outcome_Physical, Migraine frequency is a Outcome_Other, Duration is a Outcome_Other, slight body weight gain is a Outcome_Adverse-effects, abdominal pain is a Outcome_Adverse-effects, childhood migraine . is a Participant_Condition

75521_task1

Sentence: [ Prevention of migraine with flunarizine and acetylsalicylic acid . A double-blind study ] . UNLABELLED 30 children between 7 and 17 years suffering from at least 2 attacks/month of common or classical migraine since more than 1 year were studied . After clinical exclusion of symptomatic headache 4 weeks were documented by means of a migraine diary . Prophylaxis with Calcium entry blocker Flunarizine ( Sibelium ) or Thromboxane A inhibitor Acetylsalicylic acid ( ASS ) was carried out in a double blind design for 3 months . Medication was given as one dosage in the evening : 2-5 mg/kg KG ASS or 5-10 mg Flunarizine . Documented attack frequency and duration were controlled at monthly physical examinations . Final results showed no differences in significant reduction of attack frequency or symptoms between both different therapeutic principals . 72.4 % ( ASS 73.3 % ; Flunarizine 71.4 % ) of patients were attack-free or had at least a 50 % reduction . Migraine frequency of initially 7-8 was reduced to 1-2 attacks/month . Duration remained constant in both groups ( 1-3 h ) . Side effects were slight body weight gain or abdominal pain after intake , prophylaxis had not to be interrupted therefore . Longtime prognosis is not yet possible because the time of observation is too short so far . CONCLUSION Both substances are definitely useful and have few side effects in childhood migraine . If the response to one is insufficient the other substance should be tried . Instructions: please typing these entity words according to sentence: migraine, flunarizine, acetylsalicylic acid, 30, children between 7 and 17, common or classical migraine, blocker Flunarizine ( Sibelium ), Acetylsalicylic acid ( ASS ), attack frequency and duration, reduction of attack frequency or symptoms, Migraine frequency, Duration, slight body weight gain, abdominal pain, childhood migraine . Options: Intervention_Pharmacological, Outcome_Adverse-effects, Participant_Condition, Participant_Age, Outcome_Physical, Participant_Sample-size, Outcome_Other, Outcome_Mental

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[ Prevention of migraine with flunarizine and acetylsalicylic acid . A double-blind study ] . UNLABELLED 30 children between 7 and 17 years suffering from at least 2 attacks/month of common or classical migraine since more than 1 year were studied . After clinical exclusion of symptomatic headache 4 weeks were documented by means of a migraine diary . Prophylaxis with Calcium entry blocker Flunarizine ( Sibelium ) or Thromboxane A inhibitor Acetylsalicylic acid ( ASS ) was carried out in a double blind design for 3 months . Medication was given as one dosage in the evening : 2-5 mg/kg KG ASS or 5-10 mg Flunarizine . Documented attack frequency and duration were controlled at monthly physical examinations . Final results showed no differences in significant reduction of attack frequency or symptoms between both different therapeutic principals . 72.4 % ( ASS 73.3 % ; Flunarizine 71.4 % ) of patients were attack-free or had at least a 50 % reduction . Migraine frequency of initially 7-8 was reduced to 1-2 attacks/month . Duration remained constant in both groups ( 1-3 h ) . Side effects were slight body weight gain or abdominal pain after intake , prophylaxis had not to be interrupted therefore . Longtime prognosis is not yet possible because the time of observation is too short so far . CONCLUSION Both substances are definitely useful and have few side effects in childhood migraine . If the response to one is insufficient the other substance should be tried .

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[ "Outcome_Physical", "Intervention_Pharmacological", "Participant_Condition", "Participant_Age", "Outcome_Adverse-effects", "Outcome_Other", "Outcome_Mental", "Participant_Sample-size" ]