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= = prognosis = =
acute myeloid leukemia is a curable disease the chance of cure for a specific person depends on a number of prognostic factors
= = = <unk> = = =
the single most important prognostic factor in aml is cytogenetics or the chromosomal structure of the leukemic cell certain cytogenetic abnormalities are associated with very good outcomes ( for example the ( 15 17 ) translocation in acute promyelocytic leukemia ) about half of people with aml have normal cytogenetics they fall into an intermediate risk group a number of other cytogenetic abnormalities are known to associate with a poor prognosis and a high risk of relapse after treatment
the first publication to address cytogenetics and prognosis was the mrc trial of 1998
later the southwest oncology group and eastern cooperative oncology group and later still cancer and leukemia group b published other mostly overlapping lists of cytogenetics prognostication in leukemia
= = = <unk> syndrome = = =
aml which arises from a pre @@ existing myelodysplastic syndrome ( mds ) or myeloproliferative disease ( so @@ called secondary aml ) has a worse prognosis as does treatment @@ related aml arising after chemotherapy for another previous malignancy both of these entities are associated with a high rate of unfavorable cytogenetic abnormalities
= = = other prognostic markers = = =
in some studies age > 60 years and elevated lactate dehydrogenase level were also associated with poorer outcomes as with most forms of cancer performance status ( ie the general physical condition and activity level of the person ) plays a major role in prognosis as well
= = = = genotype = = = =
a large number of molecular alterations are under study for their prognostic impact in aml however only flt3 @@ itd <unk> <unk> and c @@ kit are currently included in validated international risk stratification schema these are expected to increase rapidly in the near future flt3 internal tandem duplications ( <unk> ) have been shown to confer a poorer prognosis in aml with normal cytogenetics several flt3 inhibitors have undergone clinical trials with mixed results two other mutations <unk> and <unk> <unk> are associated with improved outcomes especially in people with normal cytogenetics and are used in current risk stratification algorithms
researchers are investigating the clinical significance of c @@ kit mutations in aml these are prevalent and potentially clinically relevant because of the availability of tyrosine kinase inhibitors such as <unk> and <unk> that can block the activity of c @@ kit pharmacologically it is expected that additional markers ( eg <unk> <unk> and tp53 ) that have consistently been associated with an inferior outcome will soon be included in these recommendations the prognostic importance of other mutated genes ( eg <unk> <unk> <unk> ) is less clear
= = = expectation of cure = = =
cure rates in clinical trials have ranged from 20 45 although clinical trials often include only younger people and those able to tolerate aggressive therapies the overall cure rate for all people with aml ( including the elderly and those unable to tolerate aggressive therapy ) is likely lower cure rates for promyelocytic leukemia can be as high as 98
= = epidemiology = =
acute myeloid leukemia is a relatively rare cancer there are approximately 10 @@ 500 new cases each year in the united states and the incidence rate has remained stable from 1995 through 2005 aml accounts for 1 @@ 2 of all cancer deaths in the united states
the incidence of aml increases with age the median age at diagnosis is 63 years aml accounts for about 90 of all acute leukemias in adults but is rare in children the rate of therapy @@ related aml ( that is aml caused by previous chemotherapy ) is rising therapy @@ related disease currently accounts for about 10 20 of all cases of aml aml is slightly more common in men with a male @@ to @@ female ratio of 1 @@ 3 1
there is some geographic variation in the incidence of aml in adults the highest rates are seen in north america europe and oceania while adult aml is rarer in asia and latin america in contrast childhood aml is less common in north america and india than in other parts of asia these differences may be due to population genetics environmental factors or a combination of the two
= = = uk = = =
aml accounts for 34 of all leukaemia cases in the uk and around 2 @@ 900 people were diagnosed with the disease in 2011
= = history = =
the first published description of a case of leukemia in medical literature dates to 1827 when french physician alfred @@ armand @@ louis @@ marie velpeau described a 63 @@ year @@ old florist who developed an illness characterized by fever weakness urinary stones and substantial enlargement of the liver and spleen velpeau noted the blood of this person had a consistency like gruel and speculated the appearance of the blood was due to white corpuscles in 1845 a series of people who died with enlarged <unk> and changes in the colors and consistencies of their blood was reported by the edinburgh @@ based pathologist jh bennett he used the term <unk> to describe this pathological condition
the term leukemia was coined by rudolf virchow the renowned german pathologist in 1856 as a pioneer in the use of the light microscope in pathology virchow was the first to describe the abnormal excess of white blood cells in people with the clinical syndrome described by velpeau and bennett as virchow was uncertain of the etiology of the white blood cell excess he used the purely descriptive term leukemia ( greek white blood ) to refer to the condition
further advances in the understanding of acute myeloid leukemia occurred rapidly with the development of new technology in 1877 paul ehrlich developed a technique of staining blood films which allowed him to describe in detail normal and abnormal white blood cells wilhelm <unk> introduced the term acute leukemia in 1889 to differentiate rapidly progressive and fatal leukemias from the more indolent chronic leukemias the term myeloid was coined by franz ernst christian neumann in 1869 as he was the first to recognize white blood cells were made in the bone marrow ( greek <unk> <unk> = ( bone ) marrow ) as opposed to the spleen the technique of bone marrow examination to diagnose leukemia was first described in 1879 by <unk> finally in 1900 the myeloblast which is the malignant cell in aml was characterized by otto <unk> who divided the leukemias into myeloid and lymphocytic
in 2008 aml became the first cancer genome to be fully sequenced dna extracted from leukemic cells were compared to unaffected skin the leukemic cells contained acquired mutations in several genes that had not previously been associated with the disease
= = pregnancy = =
leukemia is rarely associated with pregnancy affecting only about 1 in 10 @@ 000 pregnant women how it is handled depends primarily on the type of leukemia acute leukemias normally require prompt aggressive treatment despite significant risks of pregnancy loss and birth defects especially if chemotherapy is given during the developmentally sensitive first trimester
= love me like you =
love me like you is a song recorded by british girl group little mix for their third studio album get weird ( 2015 ) the song was released on 25 september 2015 as the second single from the album produced by steve mac he co @@ wrote the song with iain james camille purcell and james newman backed by an instrumental of pianos bells sax and percussion the song is a down @@ tempo retro homage to doo @@ wop with lyrics about puppy love its composition was compared by several critics to motown artists of the 1950s and 1960s namely the ronettes the supremes and shadow morton
critical response to love me like you was positive critics praised its vintage style and highlighted it as an album standout it reached number 11 on the uk singles chart and has been certified gold by the bpi the accompanying music video for the song was set at a high school dance unbeknownst to each member of the group they had been invited to attend by the same date after previously meeting him in different situations he arrives with another girl near the end of the night and they realise that he had all been invited by the same guy and end up dateless little mix have performed the track on both the australian and british versions of the x factor and on good morning america in the united states
= = background and release = =
love me like you was written by steve mac camille purcell iain james and james newman for little mix 's third studio album get weird ( 2015 ) it was published by rokstone music ltd under exclusive licence to bmg rights management ( uk ) ltd kobalt music group sony / atv music publishing black butter music publishing and bmg rights management the song was produced by mac and mixed by serban ghenea at mixstar studios in virginia beach virginia it was engineered for mixing by john hanes and engineered by chris laws and dann <unk> and mastered by tom coyne and randy merrill at sterling sound studios in new york the track was recorded at rokstone studios in london purcell also provided background vocals the keyboards were performed by mac and the guitars were played by paul <unk> laws and <unk> performed the drums and the percussion respectively
the group announced on 9 september 2015 that love me like you would be the second single to be released from the album and that it would be made available to pre @@ order on 11 september and be released on 25 september it was released by syco and columbia in ireland and the united kingdom on 25 september 2015 the single 's artwork was released on the same day in their review mtv news joked that the group were suggesting that it would be number @@ one due to each of the band members eyeline writing we can 't help but get the hint they 're on the hunt for <unk> chart topping trophy leigh @@ anne clearly thinks she can see it in the distance jesy is just imagining it with her brain jade definitely thinks she can hear the noise of records being sold and perrie is convinced it 's on the floor m magazine writer heather thompson described the artwork as vibrant a collection of alternate versions called love me like you ( the collection ) was also released in australia and new zealand in addition to ireland and the united kingdom on 16 october 2015 it consists of a christmas mix several remixes and an instrumental version of love me like you and another album track called lightning
= = composition = =
love me like you has been described as a down @@ tempo ode to ' 60s doo @@ wop retro style pop song which lasts for a duration of three minutes seventeen seconds the song is composed in the key of g major using common time and a tempo of 106 beats per minute instrumentation is provided by vintage pianos bells and a pumping tenor sax the use of percussion gives the a track a more modern style during the track the band members vocal range spans one octave from the low note of d4 to the high note of e5
the song opens with the group harmonising sha la la la over pianos the lyrics are about puppy love as they <unk> sing last night i lay in bed so blue / cause ' i realized the truth / they can 't love me like you / i tried to find somebody new / baby they ain 't got a clue / can 't love me like you fuse writer jeff benjamin described the song as being reminiscent of 1960s girl group the ronettes but with a more modern feel for 2015 radio highlighting the line they try to romance me but you got that nasty and that 's what i want as an example digital spy writer lewis corner thought that the line he might got the biggest ca @@ aa @@ ar does not fool listeners into thinking that they 're not actually talking about his fiat 500 several music critics compared the song to recordings from the motown era in the 1950s and 1960s with andy gill of the independent likening it to material composed by shadow morton emilee lindner of mtv news likened the production to material composed by phil spector the christmas mix version features added church bells and jingles
= = critical reception = =
andy gill of the independent described the track as having a nice retro sound and singled it out as being one of his top three songs from the album to download along with black magic and grown writing for nme nick levine thought that love me like you was reminiscent of songs recorded by <unk> but added that little mix performed the motown style without the forced sense of fun similarly billboard writer <unk> <unk> and digital spy critic jack <unk> likened the retro style to songs performed by meghan trainor and the supremes respectively music times writer carolyn menyes praised its composition for being charming and described the track as totally charming a reviewer for press play ok commented that the song was less club night and more prom night broadcaster stephen fry criticised the track when interviewed by newsbeat about his review of a selection of songs released in 2015 he described it as horrible and a modern @@ day hideous toxic compound take on a phil spector song
= = chart performance = =
in the united kingdom love me like you debuted at number 21 on the uk singles chart on 8 october 2015 it later peaked at number 11 on 7 january 2016 it also peaked at number nine on the uk singles downloads chart the track has been certified gold by the british phonographic industry ( bpi ) denoting shipments of 400 @@ 000 copies in scotland the song reached number five it achieved success in ireland reaching number 8 on 31 december 2015 it peaked at number 66 on the belgium ultratip flanders chart on 31 october 2015 it also peaked at number 64 in slovakia number 81 in the czech republic and number 140 in france outside of europe love me like you reached number 80 on the japan hot 100 number 27 in australia and number one on the new zealand heatseekers chart
= = music video = =
the accompanying music video for love me like you was released on 10 october 2015 the video takes place at a school dance where a professor in the hall ( the same man who appeared in their previous single 's video black magic ) tells everyone that it is the last dance jade leigh @@ anne jesy and perrie are waiting for their dates to arrive scenes of the girls waiting for their date are intercut throughout the video of them sitting at a table while all of the other couples are dancing unbeknownst to them the man played by hector david junior has invited each of them to go to the dance after meeting them in different situations prior to that night he asked jade by picking her up in his car to go on a date as she gets in he invites her to be his date at the dance and presents her with a corsage to wear on her wrist on the night he mets leigh @@ anne at a high school basketball game where she and her girlfriends were watching him and some other boys play on the court he sees that she is infatuated by how good he is at the sport walks up to her and asks her to be his date by giving her a corsage he asked jesy to be his date while they were at the cinema as they shared a bucket of popcorn as he gives her the corsage she throws the bucket over her shoulder and eagerly jumps on his lap causing them to fall off the chair
finally he invited perrie to be his date after she fell off her bike while staring at him work out on a field and pouring water over his torso to cool down he helps her up and gives her a corsage toward the end of the video they sit on a bench next to the entrance and see their date walk in with another girl wearing the same corsage as the ones that he had given each of them they realise that they have all been two @@ timed by the same guy and are all dateless it ends with the girls being each other 's date and solemnly dancing whilst everyone else has a good time metro writer rebecca lewis noted that the man in the video strongly resembled perrie 's former fiancé zayn malik of one direction she also wrote that fans had noticed that she was still wearing her engagement ring in the video meaning that the video was filmed before they split up in august 2015
= = live performances = =
little mix performed love me like you live on the seventh season of the x factor in australia on 13 october 2015 capital praised their performed writing that it set an amazing example for the contestants on the show and that their vocals were pitch perfect on 1 november the group performed a love me like you / black magic medley on the twelfth series of the x factor in the united kingdom it featured the group wearing prom dresses for their performance of love me like you which were then torn off to reveal leotards to sing black magic little mix sang the track live on good morning america in the united states on 5 november they returned to the uk to perform love me like you at the radio 1 teen awards at wembley arena on 8 november and again the following morning on breakfast show lorraine love me like you was included on the set @@ list of their segment at capital 's annual jingle bell ball on 6 december along with the other singles to be released get weird black magic and secret love song as well as previous singles salute move and wings
= = track listing = =
digital download
love me like you 3 17
digital download the collection
love me like you ( christmas mix ) 3 29
lightning 5 09
love me like you ( j @@ vibe reggae remix ) 3 04
love me like you ( bimbo jones remix ) 3 07
love me like you ( 7th heaven remix ) 3 10
love me like you ( exclusive interview ) 3 16
love me like you ( instrumental ) 3 15
= = charts and certifications = =
= shaoguan incident =