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of aspirin-containing drugs) were implemented, aspirin taken by children declined considerably in the United States, as did the number of reported cases of Reye's syndrome; a similar decline was found in the United Kingdom after warnings against pediatric aspirin use were issued. The U.S. Food and Drug Administration now recommends aspirin (or aspirin-containing products) should not be given to anyone under the age of 12 who has a fever, and the UK National Health Service recommends children who are under 16 years of age should not take aspirin, unless it is on the advice of a doctor. For a small
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Aspirin
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] |
8002
|
number of people, taking aspirin can result in symptoms resembling an allergic reaction, including hives, swelling, and headache. The reaction is caused by salicylate intolerance and is not a true allergy, but rather an inability to metabolize even small amounts of aspirin, resulting in an overdose. Aspirin and other NSAIDs, such as ibuprofen, may delay the healing of skin wounds. Aspirin may however help heal venous leg ulcers that have not healed following usual treatment. Aspirin can induce swelling of skin tissues in some people. In one study, angioedema appeared one to six hours after ingesting aspirin in some of
|
Aspirin
|
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] |
8003
|
the people. However, when the aspirin was taken alone, it did not cause angioedema in these people; the aspirin had been taken in combination with another NSAID-induced drug when angioedema appeared. Aspirin causes an increased risk of cerebral microbleeds having the appearance on MRI scans of 5 to 10 mm or smaller, hypointense (dark holes) patches. Such cerebral microbleeds are important, since they often occur prior to ischemic stroke or intracerebral hemorrhage, Binswanger disease, and Alzheimer's disease. A study of a group with a mean dosage of aspirin of 270 mg per day estimated an average absolute risk increase in
|
Aspirin
|
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] |
8004
|
intracerebral hemorrhage (ICH) of 12 events per 10,000 persons. In comparison, the estimated absolute risk reduction in myocardial infarction was 137 events per 10,000 persons, and a reduction of 39 events per 10,000 persons in ischemic stroke. In cases where ICH already has occurred, aspirin use results in higher mortality, with a dose of about 250 mg per day resulting in a relative risk of death within three months after the ICH around 2.5 (95% confidence interval 1.3 to 4.6). Aspirin and other NSAIDs can cause abnormally high blood levels of potassium by inducing a hyporeninemic hypoaldosteronic state via inhibition
|
Aspirin
|
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] |
8005
|
of prostaglandin synthesis; however, these agents do not typically cause hyperkalemia by themselves in the setting of normal renal function and euvolemic state. Aspirin can cause prolonged bleeding after operations for up to 10 days. In one study, 30 of 6499 people having elective surgery required reoperations to control bleeding. Twenty had diffuse bleeding and 10 had bleeding from a site. Diffuse, but not discrete, bleeding was associated with the preoperative use of aspirin alone or in combination with other NSAIDS in 19 of the 20 diffuse bleeding people. On 9 July 2015, the FDA toughened warnings of increased heart
|
Aspirin
|
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8006
|
attack and stroke risk associated with nonsteroidal anti-inflammatory drugs (NSAID). Aspirin is an NSAID but is not affected by the new warnings. Aspirin overdose can be acute or chronic. In acute poisoning, a single large dose is taken; in chronic poisoning, higher than normal doses are taken over a period of time. Acute overdose has a mortality rate of 2%. Chronic overdose is more commonly lethal, with a mortality rate of 25%; chronic overdose may be especially severe in children. Toxicity is managed with a number of potential treatments, including activated charcoal, intravenous dextrose and normal saline, sodium bicarbonate, and
|
Aspirin
|
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] |
8007
|
dialysis. The diagnosis of poisoning usually involves measurement of plasma salicylate, the active metabolite of aspirin, by automated spectrophotometric methods. Plasma salicylate levels in general range from 30–100 mg/l after usual therapeutic doses, 50–300 mg/l in people taking high doses and 700–1400 mg/l following acute overdose. Salicylate is also produced as a result of exposure to bismuth subsalicylate, methyl salicylate, and sodium salicylate. Aspirin is known to interact with other drugs. For example, acetazolamide and ammonium chloride are known to enhance the intoxicating effect of salicylates, and alcohol also increases the gastrointestinal bleeding associated with these types of drugs. Aspirin
|
Aspirin
|
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] |
8008
|
is known to displace a number of drugs from protein-binding sites in the blood, including the antidiabetic drugs tolbutamide and chlorpropamide, warfarin, methotrexate, phenytoin, probenecid, valproic acid (as well as interfering with beta oxidation, an important part of valproate metabolism), and other NSAIDs. Corticosteroids may also reduce the concentration of aspirin. Ibuprofen can negate the antiplatelet effect of aspirin used for cardioprotection and stroke prevention. The pharmacological activity of spironolactone may be reduced by taking aspirin, and it is known to compete with penicillin G for renal tubular secretion. Aspirin may also inhibit the absorption of vitamin C. Aspirin decomposes
|
Aspirin
|
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] |
8009
|
rapidly in solutions of ammonium acetate or the acetates, carbonates, citrates, or hydroxides of the alkali metals. It is stable in dry air, but gradually hydrolyses in contact with moisture to acetic and salicylic acids. In solution with alkalis, the hydrolysis proceeds rapidly and the clear solutions formed may consist entirely of acetate and salicylate. Like flour mills, factories that make aspirin tablets must pay attention to how much of the powder gets into the air inside the building, because the powder-air mixture can be explosive. The National Institute for Occupational Safety and Health (NIOSH) has set a recommended exposure
|
Aspirin
|
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] |
8010
|
limit in the United States of 5 mg/m (time-weighted average). In 1989, the Occupational Safety and Health Administration (OSHA) set a legal permissible exposure limit for aspirin of 5 mg/m, but this was vacated by the AFL-CIO v. OSHA decision in 1993. The synthesis of aspirin is classified as an esterification reaction. Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid's hydroxyl group into an ester group (R-OH → R-OCOCH). This process yields aspirin and acetic acid, which is considered a byproduct of this reaction. Small amounts of sulfuric acid (and
|
Aspirin
|
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8011
|
occasionally phosphoric acid) are almost always used as a catalyst. This method is commonly employed in undergraduate teaching labs. Formulations containing high concentrations of aspirin often smell like vinegar because aspirin can decompose through hydrolysis in moist conditions, yielding salicylic and acetic acids. Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of , and a boiling point of . Its acid dissociation constant (p"K") is 3.5 at . Polymorphism, or the ability of a substance to form more than one crystal structure, is important in the development of pharmaceutical ingredients.
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Aspirin
|
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] |
8012
|
Many drugs are receiving regulatory approval for only a single crystal form or polymorph. For a long time, only one crystal structure for aspirin was known. That aspirin might have a second crystalline form was suspected since the 1960s. The elusive second polymorph was first discovered by Vishweshwar and coworkers in 2005, and fine structural details were given by Bond "et al." A new crystal type was found after attempted cocrystallization of aspirin and levetiracetam from hot acetonitrile. The form II is only stable at 100K and reverts to form I at ambient temperature. In the (unambiguous) form I, two
|
Aspirin
|
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] |
8013
|
salicylic molecules form centrosymmetric dimers through the acetyl groups with the (acidic) methyl proton to carbonyl hydrogen bonds, and in the newly claimed form II, each salicylic molecule forms the same hydrogen bonds with two neighboring molecules instead of one. With respect to the hydrogen bonds formed by the carboxylic acid groups, both polymorphs form identical dimer structures. In 1971, British pharmacologist John Robert Vane, then employed by the Royal College of Surgeons in London, showed aspirin suppressed the production of prostaglandins and thromboxanes. For this discovery he was awarded the 1982 Nobel Prize in Physiology or Medicine, jointly with
|
Aspirin
|
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] |
8014
|
Sune Bergström and Bengt Ingemar Samuelsson. Aspirin's ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX; officially known as prostaglandin-endoperoxide synthase, PTGS) enzyme required for prostaglandin and thromboxane synthesis. Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the PTGS enzyme (Suicide inhibition). This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors. Low-dose aspirin use irreversibly blocks the formation of thromboxane A in platelets, producing an inhibitory effect on platelet
|
Aspirin
|
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] |
8015
|
aggregation during the lifetime of the affected platelet (8–9 days). This antithrombotic property makes aspirin useful for reducing the incidence of heart attacks in people who have had a heart attack, unstable angina, ischemic stroke or transient ischemic attack. 40 mg of aspirin a day is able to inhibit a large proportion of maximum thromboxane A release provoked acutely, with the prostaglandin I2 synthesis being little affected; however, higher doses of aspirin are required to attain further inhibition. Prostaglandins, local hormones produced in the body, have diverse effects, including the transmission of pain information to the brain, modulation of the
|
Aspirin
|
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8016
|
hypothalamic thermostat, and inflammation. Thromboxanes are responsible for the aggregation of platelets that form blood clots. Heart attacks are caused primarily by blood clots, and low doses of aspirin are seen as an effective medical intervention for acute myocardial infarction. At least two different types of cyclooxygenases, COX-1 and COX-2, are acted on by aspirin. Aspirin irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2. COX-2 normally produces prostanoids, most of which are proinflammatory. Aspirin-modified PTGS2 produces lipoxins, most of which are anti-inflammatory. Newer NSAID drugs, COX-2 inhibitors (coxibs), have been developed to inhibit only PTGS2, with the intent
|
Aspirin
|
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] |
8017
|
to reduce the incidence of gastrointestinal side effects. However, several of the new COX-2 inhibitors, such as rofecoxib (Vioxx), have been withdrawn in the last decade, after evidence emerged that PTGS2 inhibitors increase the risk of heart attack and stroke. Endothelial cells lining the microvasculature in the body are proposed to express PTGS2, and, by selectively inhibiting PTGS2, prostaglandin production (specifically, PGI2; prostacyclin) is downregulated with respect to thromboxane levels, as PTGS1 in platelets is unaffected. Thus, the protective anticoagulative effect of PGI2 is removed, increasing the risk of thrombus and associated heart attacks and other circulatory problems. Since platelets
|
Aspirin
|
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] |
8018
|
have no DNA, they are unable to synthesize new PTGS once aspirin has irreversibly inhibited the enzyme, an important difference with reversible inhibitors. Furthermore, aspirin, while inhibiting the ability of COX-2 to form pro-inflammatory products such as the prostaglandins, converts this enzyme's activity from a prostaglandin-forming cyclooxygenase to a lipoxygenase-like enzyme: aspirin-treated COX-2 metabolizes a variety of polyunsaturated fatty acids to hydroperoxy products which are then further metabolized to specialized proresolving mediators such as the aspirin-triggered lipoxins, aspirin-triggered resolvins, and aspirin-triggered maresins. These mediators possess potent anti-inflammatory activity. It is proposed that this aspirin-triggered transition of COX-2 from cyclooxygenase to
|
Aspirin
|
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] |
8019
|
lipoxygenase activity and the consequential formation of specialized proresolving mediators contributes to the anti-inflammatory effects of aspirin. Aspirin has been shown to have at least three additional modes of action. It uncouples oxidative phosphorylation in cartilaginous (and hepatic) mitochondria, by diffusing from the inner membrane space as a proton carrier back into the mitochondrial matrix, where it ionizes once again to release protons. Aspirin buffers and transports the protons. When high doses are given, it may actually cause fever, owing to the heat released from the electron transport chain, as opposed to the antipyretic action of aspirin seen with lower
|
Aspirin
|
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8020
|
doses. In addition, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduced leukocyte adhesion is an important step in the immune response to infection; however, evidence is insufficient to show aspirin helps to fight infection. More recent data also suggest salicylic acid and its derivatives modulate signaling through NF-κB. NF-κB, a transcription factor complex, plays a central role in many biological processes, including inflammation. Aspirin is readily broken down in the body to salicylic acid, which itself has anti-inflammatory, antipyretic, and analgesic effects. In
|
Aspirin
|
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0.2945496737957001
] |
8021
|
2012, salicylic acid was found to activate AMP-activated protein kinase, which has been suggested as a possible explanation for some of the effects of both salicylic acid and aspirin. The acetyl portion of the aspirin molecule has its own targets. Acetylation of cellular proteins is a well-established phenomenon in the regulation of protein function at the post-translational level. Aspirin is able to acetylate several other targets in addition to COX isoenzymes. These acetylation reactions may explain many hitherto unexplained effects of aspirin. Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral
|
Aspirin
|
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] |
8022
|
administration. Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionised. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion. About 50–80% of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads
|
Aspirin
|
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] |
8023
|
to more free salicylate and increased toxicity. The volume of distribution is 0.1–0.2 L/kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates. As much as 80% of therapeutic doses of salicylic acid is metabolized in the liver. Conjugation with glycine forms salicyluric acid, and with glucuronic acid to form two different glucuronide esters. The conjugate with the acetyl group intact is referred to as the "acyl glucuronide"; the deacetylated conjugate is the "phenolic glucuronide". These metabolic pathways have only a limited capacity. Small amounts of salicylic acid are also hydroxylated to gentisic acid. With
|
Aspirin
|
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] |
8024
|
large salicylate doses, the kinetics switch from first-order to zero-order, as metabolic pathways become saturated and renal excretion becomes increasingly important. Salicylates are excreted mainly by the kidneys as salicyluric acid (75%), free salicylic acid (10%), salicylic phenol (10%), and acyl glucuronides (5%), gentisic acid (< 1%), and 2,3-dihydroxybenzoic acid. When small doses (less than 250 mg in an adult) are ingested, all pathways proceed by first-order kinetics, with an elimination half-life of about 2.0 h to 4.5 h. When higher doses of salicylate are ingested (more than 4 g), the half-life becomes much longer (15 h to 30 h),
|
Aspirin
|
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] |
8025
|
because the biotransformation pathways concerned with the formation of salicyluric acid and salicyl phenolic glucuronide become saturated. Renal excretion of salicylic acid becomes increasingly important as the metabolic pathways become saturated, because it is extremely sensitive to changes in urinary pH. A 10- to 20-fold increase in renal clearance occurs when urine pH is increased from 5 to 8. The use of urinary alkalinization exploits this particular aspect of salicylate elimination. It was found that short-term aspirin use in therapeutic doses might precipitate reversible acute renal failure when the patient was ill with glomerulonephritis or cirrhosis. Aspirin for some patients
|
Aspirin
|
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0.26937440037727356
] |
8026
|
with chronic renal insufficiency and some children with congestive heart failure was contraindicated. Medicines made from willow and other salicylate-rich plants appear in clay tablets from ancient Sumer as well as the Ebers Papyrus from ancient Egypt. Hippocrates referred to their use of salicylic tea to reduce fevers around 400 BC, and were part of the pharmacopoeia of Western medicine in classical antiquity and the Middle Ages. Willow bark extract became recognized for its specific effects on fever, pain and inflammation in the mid-eighteenth century. By the nineteenth century pharmacists were experimenting with and prescribing a variety of chemicals related
|
Aspirin
|
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] |
8027
|
to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it. By 1899, Bayer had dubbed this drug Aspirin and was selling it around the world. The word
|
Aspirin
|
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] |
8028
|
"Aspirin" was Bayer's brand name, rather than the generic name of the drug; however, Bayer's rights to the trademark were lost or sold in many countries. Aspirin's popularity grew over the first half of the twentieth century leading to fierce competition with the proliferation of aspirin brands and products. Aspirin's popularity declined after the development of acetaminophen/paracetamol in 1956 and ibuprofen in 1962. In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects, while clinical trials and other studies from the 1960s to the 1980s established aspirin's efficacy as an anti-clotting agent that reduces
|
Aspirin
|
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] |
8029
|
the risk of clotting diseases. The initial large studies on the use of low-dose aspirin to prevent heart attacks that were published in the 1970s and 1980s helped spur reform in clinical research ethics and guidelines for human subject research and US federal law, and are often cited as examples of clinical trials that included only men, but from which people drew general conclusions that did not hold true for women. Aspirin sales revived considerably in the last decades of the twentieth century, and remain strong in the twenty-first with widespread use as a preventive treatment for heart attacks and
|
Aspirin
|
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] |
8030
|
strokes. Bayer lost its trademark for Aspirin in the United States in 1918 because it had failed to use the name for its own product and had for years allowed the use of "Aspirin" by other manufacturers . Today, aspirin is a generic trademark in many countries. Aspirin, with a capital "A", remains a registered trademark of Bayer in Germany, Canada, Mexico, and in over 80 other countries, for acetylsalicylic acid in all markets, but using different packaging and physical aspects for each. Aspirin is sometimes used in veterinary medicine as an anticoagulant or to relieve pain associated with musculoskeletal
|
Aspirin
|
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0.6740312576293945,
-0.4228447377681732,
0.13993971049785614,
-0.1773664504289627,
0.040342215448617935,
0.28491365909576416
] |
8031
|
inflammation or osteoarthritis. Aspirin should only be given to animals under the direct supervision of a veterinarian, as adverse effects—including gastrointestinal issues—are common. An aspirin overdose in any species may result in salicylate poisoning, characterized by hemorrhaging, seizures, coma, and even death. Dogs are better able to tolerate aspirin than cats are. Cats metabolize aspirin slowly because they lack the glucuronide conjugates that aid in the excretion of aspirin, making it potentially toxic if dosing is not spaced out properly. No clinical signs of toxicosis occurred when cats were given 25 mg/kg of aspirin every 48 hours for 4 weeks,
|
Aspirin
|
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] |
8032
|
but the recommended dose for relief of pain and fever and for treating blood clotting diseases in cats is 10 mg/kg every 48 hours to allow for metabolization. Aspirin has shown some promise in the treatment of laminitis in horses. Aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, or inflammation. Specific inflammatory conditions in which aspirin is used include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin given shortly after a heart attack decreases the risk of death. Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood
|
Aspirin
|
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] |
8033
|
Abner In the first and second Books of Samuel, Abner ( "’Avner") was Saul's uncle and commander-in-chief of his army (1 Samuel 14:50, 20:25). His name also appears as "Abiner son of Ner", where the longer form Abiner means "my father is Ner". Abner is initially mentioned incidentally in Saul's history (1 Samuel 14:50, 17:55, 26:5), first appearing as the son of Ner, Saul's uncle, and the commander of Saul's army. He then comes to the story again as the commander who introduced David to Saul following David's killing of Goliath. He is not mentioned in the account of the
|
Abner
|
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] |
8034
|
disastrous battle of Gilboa when Saul's power was crushed. Seizing the youngest but only surviving of Saul's sons, Ish-bosheth, Abner set him up as king over Israel at Mahanaim, east of the Jordan. David, who was accepted as king by Judah alone, was meanwhile reigning at Hebron, and for some time war was carried on between the two parties. The only engagement between the rival factions which is told at length is noteworthy, inasmuch as it was preceded by an encounter at Gibeon between twelve chosen men from each side, in which the whole twenty-four seem to have perished (2
|
Abner
|
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] |
8035
|
Samuel 2:12). In the general engagement which followed, Abner was defeated and put to flight. He was closely pursued by Asahel, brother of Joab, who is said to have been "light of foot as a wild roe" (2 Samuel 2:18). As Asahel would not desist from the pursuit, though warned, Abner was compelled to slay him in self-defence. This originated a deadly feud between the leaders of the opposite parties, for Joab, as next of kin to Asahel, was by the law and custom of the country the avenger of his blood. However, according to Josephus, in Antiquities, Book 7,
|
Abner
|
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0.45845046639442444,
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] |
8036
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Chapter 1, Joab had forgiven Abner for the death of his brother, Asahel, the reason being that Abner had slain Asahel honorably in combat after he had first warned Asahel and had no other choice but to kill him out of self-defense. This battle was part of a civil war between David and Ish-bosheth, the son of Saul. After this battle Abner switched to the side of David and granted him control over the tribe of Benjamin. This act put Abner in David's favor. The real reason that Joab killed Abner was that he became a threat to his rank
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Abner
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] |
8037
|
of general. He then justifies it later by mentioning his brother. For some time afterward the war was carried on, the advantage being invariably on the side of David. At length, Ish-bosheth lost the main prop of his tottering cause by accusing Abner of sleeping with Rizpah (cf. 2 Samuel 3:7), one of Saul's concubines, an alliance which, according to contemporary notions, would imply pretensions to the throne (cf. 2 Samuel 16:21ff.). Abner was indignant at the rebuke, and immediately opened negotiations with David, who welcomed him on the condition that his wife Michal should be restored to him. This
|
Abner
|
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] |
8038
|
was done, and the proceedings were ratified by a feast. Almost immediately after, however, Joab, who had been sent away, perhaps intentionally returned and slew Abner at the gate of Hebron. The ostensible motive for the assassination was a desire to avenge Asahel, and this would be a sufficient justification for the deed according to the moral standard of the time. The conduct of David after the event was such as to show that he had no complicity in the act, though he could not venture to punish its perpetrators (2 Samuel 3:31-39; cf. 1 Kings 2:31ff.). David had Abner
|
Abner
|
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] |
8039
|
buried in Hebron, as it states in 2 Samuel 3:31-32, "And David said to all the people who were with him, 'Rend your clothes and gird yourselves with sackcloth, and wail before Abner.' And King David went after the bier. And they buried Abner in Hebron, and the king raised his voice and wept on Abner's grave, and all the people wept." Shortly after Abner's death, Ish-bosheth was assassinated as he slept (2 Samuel 4), and David became king of the reunited kingdoms (2 Samuel 5). The site known as the Tomb of Abner is located not far from the
|
Abner
|
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] |
8040
|
Cave of the Patriarchs in Hebron and receives visitors throughout the year. Many travelers have recorded visiting the tomb over the centuries. Benjamin of Tudela, who began his journeys in 1165, wrote in the journal, "The valley of Eshkhol is north of the mountain upon which Hebron stood, and the cave of Makhpela is east thereof. A bow-shot west of the cave is the sepulchre of Abner the son of Ner." A rabbi in the 12th century records visiting the tomb as reprinted in Elkan Nathan Adler's book "Jewish Travellers in the Middle Ages: 19 Firsthand Accounts". The account states,
|
Abner
|
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-0.46766045689582825
] |
8041
|
"I, Jacob, the son of R. Nathaniel ha Cohen, journeyed with much difficulty, but God helped me to enter the Holy Land, and I saw the graves of our righteous Patriarchs in Hebron and the grave of Abner the son of Ner." Adler postulates that the visit must have occurred prior to Saladin's capture of Jerusalem in 1187. Rabbi Moses Basola records visiting the tomb in 1522. He states, "Abner's grave is in the middle of Hebron; the Muslims built a mosque over it." Another visitor in the 1500s states that "at the entrance to the market in Hebron, at
|
Abner
|
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] |
8042
|
the top of the hill against the wall, Abner ben Ner is buried, in a church, in a cave." This visit was recorded in Sefer Yihus ha-Tzaddiqim (Book of Genealogy of the Righteous), a collection of travelogues from 1561. Abraham Moshe Lunz reprinted the book in 1896. Menahem Mendel of Kamenitz, considered the first hotelier in the Land of Israel, wrote about the Tomb of Abner is his 1839 book "Korot Ha-Itim", which was translated into English as "The Book of the Occurrences of the Times to Jeshurun in the Land of Israel." He states", ""Here I write of the
|
Abner
|
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] |
8043
|
graves of the righteous to which I paid my respects. Hebron – Described above is the character and order of behavior of those coming to pray at the Cave of ha-Machpelah. I went there, between the stores, over the grave of Avner ben Ner and was required to pay a Yishmaeli – the grave was in his courtyard – to allow me to enter." The author and traveler J. J. Benjamin mentioned visiting the tomb in his book "Eight Years in Asia and Africa" (1859, Hanover). He states, "On leaving the Sepulchre of the Patriarchs, and proceeding on the road
|
Abner
|
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] |
8044
|
leading to the Jewish quarter, to the left of the courtyard, is seen a Turkish dwelling house, by the side of which is a small grotto, to which there is a descent of several steps. This is the tomb of Abner, captain of King Saul. It is held in much esteem by the Arabs, and the proprietor of it takes care that it is always kept in the best order. He requires from those who visit it a small gratuity." The British scholar Israel Abrahams wrote in his 1912 book "The Book of Delight and Other Papers", "Hebron was the
|
Abner
|
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] |
8045
|
seat of David’s rule over Judea. Abner was slain here by Joab, and was buried here – they still show Abner’s tomb in the garden of a large house within the city. By the pool at Hebron were slain the murderers of Ishbosheth..." Over the years the tomb fell into disrepair and neglect. It was closed to the public in 1994. In 1996, a group of 12 Israeli women filed a petition with the Supreme Court requesting the government to reopen the Tomb of Abner. More requests were made over the years and eventually arrangements were made to have the
|
Abner
|
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8046
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site open to the general public on ten days throughout the year corresponding to the ten days that the Isaac Hall of the Cave of the Patriarchs is open. In early 2007 new mezuzot were affixed to the entrance of the site. Abner In the first and second Books of Samuel, Abner ( "’Avner") was Saul's uncle and commander-in-chief of his army (1 Samuel 14:50, 20:25). His name also appears as "Abiner son of Ner", where the longer form Abiner means "my father is Ner". Abner is initially mentioned incidentally in Saul's history (1 Samuel 14:50, 17:55, 26:5), first appearing
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Abner
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8047
|
Ahmed I Ahmed I ( ""; ; April 1590 – 22 November 1617) was the Sultan of the Ottoman Empire from 1603 until his death in 1617. Ahmed's reign is noteworthy for marking the end of the Ottoman tradition of royal fratricide; henceforth Ottoman rulers would no longer execute their brothers upon accession to the throne. He is also well known for his construction of the Blue Mosque, one of the most famous mosques in Turkey. Ahmed was probably born in April 1590 at the Manisa Palace, Manisa, when his father Şehzade Mehmed was still a prince and the governor
|
"Ahmed I"
|
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] |
8048
|
of the Sanjak of Manisa. His mother was Handan Sultan. After his grandfather Murad III's death in 1595, his father came to Constantinople and ascended the throne as Sultan Mehmed III. Mehmed ordered the execution of nineteen of his own brothers and half brothers. Ahmed's elder brother Şehzade Mahmud was also executed by his father Mehmed on 7 June 1603, just before Mehmed's own death on 22 December 1603. Mahmud was buried along with his mother in a separate mausoleum built by Ahmed in Şehzade Mosque, Constantinople. Ahmed ascended the throne after his father's death in 1603, at the age
|
"Ahmed I"
|
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] |
8049
|
of thirteen, when his powerful grandmother Safiye Sultan was still alive. A far lost uncle of Ahmed, Yahya, resented his accession to the throne and spent his life scheming to become Sultan. Ahmed broke with the traditional fratricide following previous enthronements and did not order the execution of his brother Mustafa. Instead Mustafa was sent to live at the old palace at Bayezit along with their grandmother Safiye Sultan. This was most likely due to Ahmed's young age - he had not yet demonstrated his ability to sire children, and Mustafa was then the only other candidate for the Ottoman
|
"Ahmed I"
|
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] |
8050
|
throne. His brother's execution would have endangered the dynasty, and thus he was spared. In the earlier part of his reign Ahmed I showed decision and vigor, which were belied by his subsequent conduct. The wars in Hungary and Persia, which attended his accession, terminated unfavourably for the empire. Its prestige was further tarnished in the Treaty of Zsitvatorok, signed in 1606, whereby the annual tribute paid by Austria was abolished. Following the crushing defeat in the Ottoman–Safavid War (1603–18) against the neighbouring rivals Safavid Empire, led by Shah Abbas the Great, Georgia, Azerbaijan and other vast territories in the
|
"Ahmed I"
|
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8051
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Caucasus were ceded back to Persia per the Treaty of Nasuh Pasha in 1612, territories that had been temporarily conquered in the Ottoman–Safavid War (1578–90). The new borders were drawn per the same line as confirmed in the Peace of Amasya of 1555. The Ottoman–Safavid War had begun shortly before the death of Ahmed's father Mehmed III. Upon ascending the throne, Ahmed I appointed Cigalazade Yusuf Sinan Pasha as the commander of the eastern army. The army marched from Constantinople on 15 June 1604, which was too late, and by the time it had arrived on the eastern front on
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"Ahmed I"
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] |
8052
|
8 November 1604, the Safavid army had captured Yerevan and entered the Kars Eyalet, and could only be stopped in Akhaltsikhe. Despite the conditions being favourable, Sinan Pasha decided to stay for the winter in Van, but then marched to Erzurum to stop an incoming Safavid attack. This caused unrest within the army and the year was practically wasted for the Ottomans. In 1605, Sinan Pasha marched to take Tabriz, but the army was undermined by Köse Sefer Pasha, the Beylerbey of Erzurum, marching independently from Sinan Pasha and consequently being taken prisoner by the Safavids. The Ottoman army was
|
"Ahmed I"
|
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] |
8053
|
routed at Urmia and had to flee firstly to Van and then to Diyarbekir. Here, Sinan Pasha sparked a rebellion by executing the Beylerbey of Aleppo, Canbulatoğlu Hüseyin Pasha, who had come to provide help, upon the pretext that he had arrived too late. He soon died himself and the Safavid army was able to capture Ganja, Shirvan and Shamakhi in Azerbaijan. The Long Turkish War between the Ottomans and the Habsburg Monarchy had been going on for over a decade by the time Ahmed ascended the throne. Grand Vizier Malkoç Ali Pasha marched to the western front from Constantinople
|
"Ahmed I"
|
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] |
8054
|
on 3 June 1604 and arrived in Belgrade, but died there, so Lala Mehmed Pasha was appointed as the Grand Vizier and the commander of the western army. Under Mehmed Pasha, the western army recaptured Pest and Vác, but failed to capture Esztergom as the siege was lifted due to unfavourable weather and the objections of the soldiers. Meanwhile, the Prince of Transylvania, Stephen Bocskay, who struggled for the region's independence and had formerly supported the Habsburgs, sent a messenger to the Porte asking for help. Upon the promise of help, his forces also joined the Ottoman forces in Belgrade.
|
"Ahmed I"
|
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] |
8055
|
With this help, the Ottoman army besieged Esztergom and captured it on 4 November 1605. Bocskai, with Ottoman help, captured Nové Zámky (Uyvar) and forces under Tiryaki Hasan Pasha took Veszprém and Palota. Sarhoş İbrahim Pasha, the Beylerbey of Nagykanizsa (Kanije), attacked the Austrian region of Istria. However, with Jelali revolts in Anatolia more dangerous than ever and a defeat in the eastern front, Mehmed Pasha was called to Constantinople. Mehmed Pasha suddenly died there, whilst preparing to leave for the east. Kuyucu Murad Pasha then negotiated the Peace of Zsitvatorok, which abolished the tribute of 30,000 ducats paid by
|
"Ahmed I"
|
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-0.5893027186393738
] |
8056
|
Austria and addressed the Habsburg emperor as the equal of the Ottoman sultan. The Jelali revolts were a strong factor in the Ottomans' acceptance of the terms. This signaled the end of Ottoman growth in Europe. Resentment over the war with the Habsburgs and heavy taxation, along with the weakness of the Ottoman military response, combined to make the reign of Ahmed I the zenith of the Jelali revolts. Tavil Ahmed launched a revolt soon after the coronation of Ahmed I and defeated Nasuh Pasha and the Beylerbey of Anatolia, Kecdehan Ali Pasha. In 1605, Tavil Ahmed was offered the
|
"Ahmed I"
|
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] |
8057
|
position of the Beylerbey of Shahrizor to stop his rebellion, but soon afterwards he went on to capture Harput. His son, Mehmed, obtained the governorship of Baghdad with a fake firman and defeated the forces of Nasuh Pasha sent to defeat him. Meanwhile, Canbulatoğlu Ali Pasha united his forces with the Druze Sheikh Ma'noğlu Fahreddin to defeat the Amir of Tripoli Seyfoğlu Yusuf. He went on to take control of the Adana area, forming an army and issuing coins. His forces routed the army of the newly appointed Beylerbey of Aleppo, Hüseyin Pasha. Grand Vizier Boşnak Dervish Mehmed Pasha was
|
"Ahmed I"
|
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] |
8058
|
executed for the weakness he showed against the Jelalis. He was replaced by Kuyucu Murad Pasha, who marched to Syria with his forces to defeat the 30,000-strong rebel army with great difficulty, albeit with a decisive result, on 24 October 1607. Meanwhile, he pretended to forgive the rebels in Anatolia and appointed the rebel Kalenderoğlu, who was active in Manisa and Bursa, as the sanjakbey of Ankara. Baghdad was recaptured in 1607 as well. Canbulatoğlu Ali Pasha fled to Constantinople and asked for forgiveness from Ahmed I, who appointed him to Timişoara and later Belgrade, but then executed him due
|
"Ahmed I"
|
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] |
8059
|
to his misrule there. Meanwhile, Kalenderoğlu was not allowed in the city by the people of Ankara and rebelled again, only to be crushed by Murad Pasha's forces. Kalenderoğlu ended up fleeing to Persia. Murad Pasha then suppressed some smaller revolts in Central Anatolia and suppressed other Jelali chiefs by inviting them to join the army. Due to the widespread violence of the Jelali revolts, a great number of people had fled their villages and a lot of villages were destroyed. Some military chiefs had claimed these abandoned villages as their property. This deprived the Porte of tax income and
|
"Ahmed I"
|
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] |
8060
|
on 30 September 1609, Ahmed I issued a letter guaranteeing the rights of the villagers. He then worked on the resettlement of abandoned villages. The new Grand Vizier, Nasuh Pasha, did not want to fight with the Safavids. The Safavid Shah also sent a letter saying that he was willing to sign a peace, with which he would have to send 200 loads of silk every year to Constantinople. On 20 November 1612, the Treaty of Nasuh Pasha was signed, which ceded all the lands the Ottoman Empire had gained in the war of 1578–90 back to Persia and reinstated
|
"Ahmed I"
|
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] |
8061
|
the 1555 boundaries. However, the peace ended in 1615 when the Shah did not send the 200 loads of silk. On 22 May 1615, Grand Vizier Öküz Mehmed Pasha was assigned to organize an attack on Persia. Mehmed Pasha delayed the attack till the next year, until when the Safavids made their preparations and attacked Ganja. In April 1616, Mehmed Pasha left Aleppo with a large army and marched to Yerevan, where he failed to take the city and withdrew to Erzurum. He was removed from his post and replaced by Damat Halil Pasha. Halil Pasha went for the winter
|
"Ahmed I"
|
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] |
8062
|
to Diyarbekir, while the Khan of Crimea, Canibek Giray, attacked the areas of Ganja, Nakhichevan and Julfa. Ahmed I renewed trade treaties with England, France and Venice. In July 1612, the first ever trade treaty with the Dutch Republic was signed. He expanded the capitulations given to France, specifying that merchants from Spain, Ragusa, Genoa, Ancona and Florence could trade under the French flag. Sultan Ahmed constructed the Sultan Ahmed Mosque, the magnum opus of the Ottoman architecture, across from the Hagia Sophia. The sultan attended the breaking of the ground with a golden pickaxe to begin the construction of
|
"Ahmed I"
|
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] |
8063
|
the mosque complex. An incident nearly broke out after the sultan discovered that the Blue Mosque contained the same number of minarets as the grand mosque of Mecca. Ahmed became furious at this fault and became remorseful until the Shaykh-ul-Islam recommended that he should erect another minaret at the grand mosque of Mecca and the matter was solved. Ahmed became delightedly involved in the eleventh comprehensive renovations of the Kaaba, which had just been damaged by flooding. He sent craftsmen from Constantinople, and the golden rain gutter that kept rain from collecting on the roof of the Ka’ba was successfully
|
"Ahmed I"
|
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] |
8064
|
renewed. It was again during the era of Sultan Ahmed that an iron web was placed inside the Zamzam Well in Mecca. The placement of this web about three feet below the water level was a response to lunatics who jumped into the well, imagining a promise of a heroic death. In Medina, the city of the Prophet Muhammad, a new pulpit made of white marble and shipped from Istanbul arrived in the mosque of the prophet and substituted the old, worn-out pulpit. It is also known that Sultan Ahmed erected two more mosques in Uskudar on the Asian side
|
"Ahmed I"
|
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] |
8065
|
of Istanbul; however, neither of them has survived. The sultan had a crest carved with the footprint of Muhammad that he would wear on Fridays and festive days and illustrated one of the most significant examples of affection to the prophet in Ottoman history. Engraved inside the crest was a poem he composed: Sultan Ahmed was known for his skills in fencing, poetry, horseback riding, and fluency in several languages. Ahmed was a poet who wrote a number of political and lyrical works under the name Bahti. But while supportive of poetry, he displayed an aversion to artistry and continued
|
"Ahmed I"
|
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8066
|
his father's neglect of miniature painting. This was connected to a devout religiosity that declared depiction of living things in art an immoral rivalry to Allah's creation. Accordingly, Ahmed patronized scholars, calligraphers, and pious men. Hence he commissioned a book entitled "The Quintessence of Histories" to be worked upon by calligraphers. He also attempted to enforce conformance to Islamic laws and traditions, restoring the old regulations that prohibited alcohol and he attempted to enforce attendance at Friday prayers and paying alms to the poor in the proper way. He was responsible for the destruction of the musical clock organ that
|
"Ahmed I"
|
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8067
|
Elizabeth I of England sent to the court during the reign of his father. The reason for this may have been Ahmed's religious objection to figurative art. Ahmed I died of typhus and gastric bleeding on 22 November 1617 at the Topkapı Palace, Istanbul. He was buried in Ahmed I Mausoleum, Sultan Ahmed Mosque. He was succeeded by his younger brother Şehzade Mustafa as Sultan Mustafa I. Later three of Ahmed's sons ascended to the throne: Osman II (r. 1618–22), Murad IV (r. 1623–40) and Ibrahim (r. 1640–48). Today, Ahmed I is remembered mainly for the construction of the Sultan
|
"Ahmed I"
|
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] |
8068
|
Ahmed Mosque (also known as the Blue Mosque), one of the masterpieces of Islamic architecture. The area in Fatih around the Mosque is today called Sultanahmet. He died at Topkapı Palace in Constantinople and is buried in a mausoleum right outside the walls of the famous mosque. In the 2015 TV series "", Ahmed I is portrayed by Turkish actor Ekin Koç. [aged 27] Ahmed I Ahmed I ( ""; ; April 1590 – 22 November 1617) was the Sultan of the Ottoman Empire from 1603 until his death in 1617. Ahmed's reign is noteworthy for marking the end of
|
"Ahmed I"
|
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] |
8069
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Ahmed II Ahmed II (Ottoman Turkish: احمد ثانى "Aḥmed-i sānī") (25 February 1643 – 6 February 1695) was the Sultan of the Ottoman Empire from 1691 to 1695. Ahmed II was born at Topkapı Palace, Constantinople, the son of Sultan Ibrahim (1640–48) by Muazzez Sultan, and succeeded his brother Suleiman II (1687–91) in 1691. Ahmed II was born on 25 February 1643, the son of Sultan Ibrahim and Muazzez Sultan. During the reigns of his older brothers, Ahmed was imprisoned in Kafes, and he stayed there almost 43 years. During his short reign, Sultan Ahmed II devoted most of his
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"Ahmed II"
|
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] |
8070
|
attention to the wars against the Habsburgs and related foreign policy, governmental and economic issues. Of these, the most important were the tax reforms and the introduction of the lifelong tax farm system (malikane) (see tax farming). Following the recovery of Belgrade under his predecessor, Suleiman II, the military frontier reached a rough stalemate on the Danube, with the Habsburgs no longer able to advance south of it, and the Ottomans attempting, ultimately unsuccessfully, to regain the initiative north of it. Among the most important features of Ahmed's reign was his reliance on Köprülüzade Fazıl Mustafa Pasha. Following his accession
|
"Ahmed II"
|
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] |
8071
|
to the throne, Sultan Ahmed II confirmed Köprülüzade Fazıl Mustafa Pasha in his office as grand vizier. In office from 1689, Fazıl Mustafa Pasha was from the famous Köprülü family of grand viziers, and like most of his Köprülü predecessors in the same office, was an able administrator and military commander. Like his father Köprülü Mehmed Pasha (grand vizier 1656–61) before him, he ordered the removal and execution of dozens of corrupt state officials of the previous regime and replaced them with men loyal to himself. He overhauled the tax system by adjusting it to the capabilities of the taxpayers
|
"Ahmed II"
|
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] |
8072
|
affected by the latest wars. He also reformed troop mobilization and increased the pool of conscripts available for the army by drafting tribesmen in the Balkans and Anatolia. In October 1690 he recaptured Belgrade (northern Serbia), a key fortress that commanded the confluence of the rivers Danube and Sava; in Ottoman hands since 1521, the fortress had been conquered by the Habsburgs in 1688. Fazıl Mustafa Pasha's victory at Belgrade was a major military achievement that gave the Ottomans hope that the military debacles of the 1680s—which had led to the loss of Hungary and Transylvania, an Ottoman vassal principality
|
"Ahmed II"
|
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] |
8073
|
ruled by pro-Istanbul Hungarian princes— could be reversed. However, the Ottoman success proved ephemeral. On 19 August 1691, Fazıl Mustafa Pasha suffered a devastating defeat at the Battle of Slankamen (northwest of Belgrade) at the hands of Ludwig Wilhelm von Baden, the Habsburg commander in chief in Hungary, fittingly nicknamed “Türkenlouis” (Louis the Turk) for his victories against the Ottomans. In the confrontation, recognized by contemporaries as “the bloodiest battle of the century,” the Ottomans suffered heavy losses: 20,000 men, including the grand vizier. With him, the sultan lost his most capable military commander and the last member of the
|
"Ahmed II"
|
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] |
8074
|
Köprülü family, who for the previous half century had been instrumental in strengthening the Ottoman military. Under Fazıl Mustafa Pasha's successors, the Ottomans suffered further defeats. In June 1692 the Habsburgs conquered Várad (Oradea, Romania), the seat of an Ottoman governor () since 1660. In 1694 they attempted to recapture Várad, but to no avail. On 12 January 1695, they surrendered the fortress of Gyula, the center of an Ottoman sanjak or subprovince since 1566. With the fall of Gyula, the only territory still in Ottoman hands in Hungary was to the east of the River Tisza and to the
|
"Ahmed II"
|
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] |
8075
|
south of the river Maros, with its center at Temesvár. Three weeks later, on 6 February 1695, Ahmed II died in Edirne Palace. Ahmed II Ahmed II (Ottoman Turkish: احمد ثانى "Aḥmed-i sānī") (25 February 1643 – 6 February 1695) was the Sultan of the Ottoman Empire from 1691 to 1695. Ahmed II was born at Topkapı Palace, Constantinople, the son of Sultan Ibrahim (1640–48) by Muazzez Sultan, and succeeded his brother Suleiman II (1687–91) in 1691. Ahmed II was born on 25 February 1643, the son of Sultan Ibrahim and Muazzez Sultan. During the reigns of his older brothers,
|
"Ahmed II"
|
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] |
8076
|
Ahmed III Ahmed III (Ottoman Turkish: احمد ثالث, "Aḥmed-i sālis") (30/31 December 16731 July 1736) was Sultan of the Ottoman Empire and a son of Sultan Mehmed IV (r. 1648–87). His mother was Emetullah Rabia Gülnuş Sultan, originally named Evmania Voria, who was an ethnic Greek. He was born at Hacıoğlu Pazarcık, in Dobruja. He succeeded to the throne in 1703 on the abdication of his brother Mustafa II (1695–1703). Nevşehirli Damat İbrahim Pasha and the Sultan's daughter, Fatma Sultan (wife of the former) directed the government from 1718 to 1730, a period referred to as the "Tulip Era". Ahmed
|
"Ahmed III"
|
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] |
8077
|
III cultivated good relations with France, doubtless in view of Russia's menacing attitude. He afforded refuge in Ottoman territory to Charles XII of Sweden (1682–1718) after the Swedish defeat at the hands of Peter I of Russia (1672–1725) in the Battle of Poltava of 1709. In 1710 Charles XII convinced Sultan Ahmed III to declare war against Russia, and the Ottoman forces under Baltacı Mehmet Pasha won a major victory at the Battle of Prut. In the aftermath, Russia returned Azov back to the Ottomans, agreed to demolish the fortress of Taganrog and others in the area, and to stop
|
"Ahmed III"
|
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] |
8078
|
interfering in the affairs of the Polish–Lithuanian Commonwealth. Forced against his will into war with Russia, Ahmed III came nearer than any Ottoman sovereign before or since to breaking the power of his northern rival, whose armies his grand vizier Nevşehirli Damat İbrahim Pasha succeeded in completely surrounding at the Pruth River Campaign in 1711. The subsequent Ottoman victories against Russia enabled the Ottoman Empire to advance to Moscow, had the Sultan wished. However, this was halted as a report reached Istanbul that the Safavids were invading the Ottoman Empire, causing a period of panic, turning the Sultan's attention away
|
"Ahmed III"
|
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] |
8079
|
from Russia. Sultan Ahmed III had become unpopular by reason of the excessive pomp and costly luxury in which he and his principal officers indulged; on September 20, 1730, a mutinous riot of seventeen Janissaries, led by the Albanian Patrona Halil, was aided by the citizens as well as the military until it swelled into an insurrection in front of which the Sultan was forced to give up the throne. Ahmed voluntarily led his nephew Mahmud I (1730–54) to the seat of sovereignty and paid allegiance to him as Sultan of the Empire. He then retired to the Kafes previously
|
"Ahmed III"
|
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8080
|
occupied by Mahmud and died at Topkapı Palace after six years of confinement. Ahmed III's twenty-seven year reign was successful. The recovery of Azov and the Morea, and the conquest of part of Persia, managed to counterbalance the Balkan territory ceded to the Habsburg Monarchy through the Treaty of Passarowitz, after the Ottoman Empire was defeated in Austro-Turkish War of 1716–18. In 1716, he sent an army of 33,000 men to capture Corfu from the Republic of Venice but that expedition eventually failed, Ahmed III left the finances of the Ottoman Empire in a flourishing condition, which had remarkably been
|
"Ahmed III"
|
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] |
8081
|
obtained without excessive taxation or extortion procedures. He was a cultivated patron of literature and art, and it was in his time that the first printing press authorized to use the Arabic or Turkish languages was set up in Istanbul, operated by Ibrahim Muteferrika (while the printing press had been introduced to Constantinople in 1480, all works published before 1729 were in Greek, Armenian, or Hebrew). It was in this reign that an important change in the government of the Danubian Principalities was introduced: previously, the Porte had appointed Hospodars, usually native Moldavian and Wallachian boyars, to administer those provinces;
|
"Ahmed III"
|
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] |
8082
|
after the Russian campaign of 1711, during which Peter the Great found an ally in Moldavia Prince Dimitrie Cantemir, the Porte began overtly deputizing Phanariote Greeks in that region, and extended the system to Wallachia after Prince Stefan Cantacuzino established links with Eugene of Savoy. The Phanariotes constituted a kind of "Dhimmi" nobility, which supplied the Porte with functionaries in many important departments of the state. In the year 1712, the Mughal Emperor Jahandar Shah, a grandson of Aurangzeb sent gifts to the Ottoman Sultan Ahmad III and referred to himself as the Ottoman Sultan's devoted admirer. The Mughal Emperor
|
"Ahmed III"
|
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] |
8083
|
Farrukhsiyar a grandson of Aurangzeb, is also known to have sent a letter to the Ottomans but this time it was received by the Grand Vizier Nevşehirli Damad Ibrahim Pasha providing a graphic description of the efforts of the Mughal commander Syed Hassan Ali Khan Barha against the Rajput and Maratha rebellion. In Voltaire's "Candide", the eponymous main character meets the deposed Ahmed III on a ship from Venice to Constantinople. The Sultan is in the company of five other deposed European monarchs, and he tells Candide, who initially doubts his credentials: I am not jesting, my name is Achmet
|
"Ahmed III"
|
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] |
8084
|
III. For several years I was Sultan; I dethroned my brother; my nephew dethroned me; they cut off the heads of my viziers; I am ending my days in the old seraglio; my nephew, Sultan Mahmoud, sometimes allows me to travel for my health, and I have come to spend the Carnival at Venice." This episode was taken up by the modern Turkish writer Nedim Gürsel as the setting of his 2001 novel "Le voyage de Candide à Istanbul". In fact, there is no evidence of the deposed Sultan being allowed to make such foreign travels, nor did Voltaire (or
|
"Ahmed III"
|
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] |
8085
|
Gürsel) assert that it had any actual historical foundation. [aged 62] Ahmed III Ahmed III (Ottoman Turkish: احمد ثالث, "Aḥmed-i sālis") (30/31 December 16731 July 1736) was Sultan of the Ottoman Empire and a son of Sultan Mehmed IV (r. 1648–87). His mother was Emetullah Rabia Gülnuş Sultan, originally named Evmania Voria, who was an ethnic Greek. He was born at Hacıoğlu Pazarcık, in Dobruja. He succeeded to the throne in 1703 on the abdication of his brother Mustafa II (1695–1703). Nevşehirli Damat İbrahim Pasha and the Sultan's daughter, Fatma Sultan (wife of the former) directed the government from 1718
|
"Ahmed III"
|
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] |
8086
|
Ainu people The Ainu or the Aynu (Ainu アィヌ "Aynu"; Japanese: "Ainu"; Russian: "Ajny"), in the historical Japanese texts the Ezo (), are an indigenous people of Japan (Hokkaido, and formerly northeastern Honshu) and Russia (Sakhalin, the Kuril Islands, and formerly the Kamchatka Peninsula). The official number of the Ainu is 25,000, but unofficially is estimated at 200,000, due to many Ainu having been completely assimilated into Japanese society and, as a result, having no knowledge of their ancestry. Recent research suggests that Ainu culture originated from a merger of the Jomon, Okhotsk and Satsumon cultures. In 1264, Ainu invaded
|
"Ainu people"
|
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8087
|
the land of Nivkh people controlled by the Yuan Dynasty, resulting in battles between Ainu and the Chinese. Active contact between the Wajin (the ethnically Japanese) and the Ainu of Ezochi (now known as Hokkaido) began in the 13th century. The Ainu formed a society of hunter-gatherers, surviving mainly by hunting and fishing. They followed a religion which was based on natural phenomena. During the Muromachi period (1336–1573), the disputes between the Japanese and Ainu developed into a war. Takeda Nobuhiro killed the Ainu leader, Koshamain. Many Ainu were subject to Japanese rule which led to a violent Ainu revolt
|
"Ainu people"
|
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] |
8088
|
such as Koshamain's Revolt () in 1456. During the Edo period (1601–1868) the Ainu, who controlled the northern island which is now named Hokkaido, became increasingly involved in trade with the Japanese who controlled the southern portion of the island. The Tokugawa bakufu (feudal government) granted the Matsumae clan exclusive rights to trade with the Ainu in the northern part of the island. Later, the Matsumae began to lease out trading rights to Japanese merchants, and contact between Japanese and Ainu became more extensive. Throughout this period the Ainu became increasingly dependent on goods imported by the Japanese, and were
|
"Ainu people"
|
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8089
|
suffering from epidemic diseases such as smallpox. Although the increased contact created by the trade between the Japanese and the Ainu contributed to increased mutual understanding, it also led to conflict which occasionally intensified into violent Ainu revolts. The most important was Shakushain's Revolt (1669–1672), an Ainu rebellion against Japanese authority. Another large-scale revolt by Ainu against Japanese rule was the Menashi-Kunashir Battle in 1789. In the 18th century, there were 80,000 Ainu. In 1868, there were about 15,000 Ainu in Hokkaido, 2000 in Sakhalin and around 100 in the Kuril islands. The beginning of the Meiji Restoration in 1868
|
"Ainu people"
|
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] |
8090
|
proved a turning point for Ainu culture. The Japanese government introduced a variety of social, political, and economic reforms in hope of modernizing the country in the Western style. One innovation involved the annexation of Hokkaido. Sjöberg quotes Baba's (1980) account of the Japanese government's reasoning: … The development of Japan's large northern island had several objectives: First, it was seen as a means to defend Japan from a rapidly developing and expansionist Russia. Second … it offered a solution to the unemployment for the former samurai class … Finally, development promised to yield the needed natural resources for a
|
"Ainu people"
|
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] |
8091
|
growing capitalist economy. In 1899, the Japanese government passed an act labelling the Ainu as "former aborigines", with the idea they would assimilate—this resulted in the Japanese government taking the land where the Ainu people lived and placing it from then on under Japanese control. Also at this time, the Ainu were granted automatic Japanese citizenship, effectively denying them the status of an indigenous group. The Ainu were becoming increasingly marginalized on their own land—over a period of only 36 years, the Ainu went from being a relatively isolated group of people to having their land, language, religion and customs
|
"Ainu people"
|
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] |
8092
|
assimilated into those of the Japanese. In addition to this, the land the Ainu lived on was distributed to the Wajin who had decided to move to Hokkaido, encouraged by the Japanese government of the Meiji era to take advantage of the island's abundant natural resources, and to create and maintain farms in the model of Western industrial agriculture. While at the time, the process was openly referred to as colonization ("takushoku" 拓殖), the notion was later reframed by Japanese elites to the currently common usage "kaitaku" (開拓), which instead conveys a sense of opening up or reclamation of the
|
"Ainu people"
|
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] |
8093
|
Ainu lands. As well as this, factories such as flour mills, beer breweries and mining practices resulted in the creation of infrastructure such as roads and railway lines, during a development period that lasted until 1904. During this time, the Ainu were forced to learn Japanese, required to adopt Japanese names, and ordered to cease religious practices such as animal sacrifice and the custom of tattooing. The 1899 act mentioned above was replaced in 1997—until then the government had stated there were no ethnic minority groups. It was not until June 6, 2008, that Japan formally recognised the Ainu as
|
"Ainu people"
|
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] |
8094
|
an indigenous group (see Official Recognition, below). The vast majority of these Wajin men are believed to have compelled Ainu women into partnering with them as local wives. Intermarriage between Japanese and Ainu was actively promoted by the Ainu to lessen the chances of discrimination against their offspring. As a result, many Ainu are indistinguishable from their Japanese neighbors, but some Ainu-Japanese are interested in traditional Ainu culture. For example, Oki, born as a child of an Ainu father and a Japanese mother, became a musician who plays the traditional Ainu instrument "tonkori". There are also many small towns in
|
"Ainu people"
|
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] |
8095
|
the southeastern or Hidaka region where ethnic Ainu live such as in Nibutani (Ainu: "Niputay"). Many live in Sambutsu especially, on the eastern coast. In 1966 the number of "pure" Ainu was about 300. Their most widely known ethnonym is derived from the word "ainu", which means "human" (particularly as opposed to "kamui", divine beings), basically neither ethnicity nor the name of a race, in the Hokkaido dialects of the Ainu language. Ainu is the word Ainu identify themselves as from their first male ancestor Aioina. Ainu also identify themselves as "Utari" ("comrade" in the Ainu language). Official documents use
|
"Ainu people"
|
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] |
8096
|
both names. On June 6, 2008, the Japanese Diet passed a bipartisan, non-binding resolution calling upon the government to recognize the Ainu people as indigenous to Japan, and urging an end to discrimination against the group. The resolution recognised the Ainu people as "an indigenous people with a distinct language, religion and culture". The government immediately followed with a statement acknowledging its recognition, stating, "The government would like to solemnly accept the historical fact that many Ainu were discriminated against and forced into poverty with the advancement of modernization, despite being legally equal to (Japanese) people." As a result of
|
"Ainu people"
|
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] |
8097
|
the Treaty of Saint Petersburg (1875), the Kuril Islands – along with their Ainu inhabitants – came under Japanese administration. A total of 83 North Kuril Ainu arrived in Petropavlovsk-Kamchatsky on September 18, 1877, after they decided to remain under Russian rule. They refused the offer by Russian officials to move to new reservations in the Commander Islands. Finally a deal was reached in 1881 and the Ainu decided to settle in the village of Yavin. In March 1881, the group left Petropavlovsk and started the journey towards Yavin on foot. Four months later they arrived at their new homes.
|
"Ainu people"
|
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8098
|
Another village, Golygino, was founded later. Under Soviet rule, both the villages were forced to disband and residents were moved to the Russian-dominated Zaporozhye rural settlement in Ust-Bolsheretsky Raion. As a result of intermarriage, the three ethnic groups assimilated to form the Kamchadal community. In 1953, K. Omelchenko, the minister for the protection of military and state secrets in the USSR, banned the press from publishing any more information on the Ainu living in the USSR. This order was revoked after two decades. , the North Kuril Ainu of Zaporozhye form the largest Ainu subgroup in Russia. The Nakamura clan
|
"Ainu people"
|
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] |
8099
|
(South Kuril Ainu on their paternal side), the smallest group, numbers just six people residing in Petropavlovsk. On Sakhalin island, a few dozen people identify themselves as Sakhalin Ainu, but many more with partial Ainu ancestry do not acknowledge it. Most of the 888 Japanese people living in Russia (2010 Census) are of mixed Japanese-Ainu ancestry, although they do not acknowledge it (full Japanese ancestry gives them the right of visa-free entry to Japan.) Similarly, no one identifies themselves as Amur Valley Ainu, although people with partial descent live in Khabarovsk. There is no evidence of living descendants of the
|
"Ainu people"
|
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] |
8100
|
Kamchatka Ainu. In the 2010 Census of Russia, close to 100 people tried to register themselves as ethnic Ainu in the village, but the governing council of Kamchatka Krai rejected their claim and enrolled them as ethnic Kamchadal. In 2011, the leader of the Ainu community in Kamchatka, Alexei Vladimirovich Nakamura, requested that Vladimir Ilyukhin (Governor of Kamchatka) and Boris Nevzorov (Chairman of the State Duma) include the Ainu in the central list of the Indigenous small-numbered peoples of the North, Siberia and the Far East. This request was also turned down. Ethnic Ainu living in Sakhalin Oblast and Khabarovsk
|
"Ainu people"
|
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0.5921903848648071,
-0.06050301343202591,
-0.4729635417461395,
-1.1280337572097778,
0.037988338619470596,
-0.0851970985531807,
-0.6507576107978821,
0.25043338537216187,
-0.2842859625816345,
-0.15428410470485687,
-0.11396852880716324,
0.708176851272583,
-0.5144921541213989,
-0.21363484859466553,
-0.4889364540576935
] |
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