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Some approved drugs, such as those based on re-formulation of an existing active ingredient (also referred to as Line-extensions) are much less expensive to develop.
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Endosymbiosis is any symbiotic relationship in which one symbiont lives within the tissues of the other, either within the cells or extracellularly.
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What is royal assent called in Belgium?
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The revolutionary army established large-scale public works programs and successfully implemented an urban and rural literacy campaign, which helped dramatically increase the literacy rate
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At the second hearing, the jury determines whether certain statutory aggravating factors exist, whether any mitigating factors exist, and, in many jurisdictions, weigh the aggravating and mitigating factors in assessing the ultimate penalty – either death or life in prison, either with or without parole
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Grazing organisms may also kill their prey species, but this is seldom the case. Give an example of an animal that feeds off of other animals for reproduction?
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Jonassohn and Björnson postulate that the major reason why no single generally accepted genocide definition has emerged is because academics have adjusted their focus to emphasise different periods and have found it expedient to use slightly different definitions to help them interpret events. What writer joined Jonassohn in the study of definitions?
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The two became friends, and for many years lived in close proximity in Paris, Chopin at 38 Rue de la Chaussée-d'Antin, and Liszt at the Hôtel de France on the Rue Lafitte, a few blocks away. When was the first time Liszt and Chopin performed together?
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When did the UN General Assembly approve the Marshall Islands joining the UN?
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What will be created in the medieval triforium?
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In July 2002, Beyoncé continued her acting career playing Foxxy Cleopatra alongside Mike Myers in the comedy film, Austin Powers in Goldmember, which spent its first weekend atop the US box office and grossed $73 million. What film did Beyoncé star in with Mike Myers in 2002?
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Who was the first woman Schwarzenegger was serious about?
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What did Princeton claim the real reasons for the approval of Li's application was
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What's the name of Singapore's centralized institute that students can attend before university
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What ward to disking become popular
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What did he receive from the locals that changed his approach?
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When the Dzungar Mongols attempted to spread their territory from what is now Xinjiang into Tibet, the Kangxi Emperor (r. When was The Qing dynasty garrison established in Tibet
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The Armenian Genocide caused widespread emigration that led to the settlement of Armenians in various countries in the world. Who is the most popular member of System of a Down?
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They were made between 965 and 970 by local craftsmen, supervised by a master mosaicist from Constantinople, who was sent by the Byzantine Emperor to the Umayyad Caliph of Spain
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How many years would Italy have to allow Italian Somaliland to become independent?
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It has been pointed out that Khmer and Indonesian classical arts were concerned with depicting the life of the gods, but to the Southeast Asian mind the life of the gods was the life of the peoples themselves—joyous, earthy, yet divine.
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The 80,000-seat Stade de France, built for the 1998 FIFA World Cup, is located just north of Paris in the commune of Saint-Denis
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The Russian Empire had entered a more aggressive phase, becoming militarily active against the Ottoman Empire and also against China, with territorial aggrandizement explicitly in mind
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After obtaining suffrage at the federal level, women quickly rose in political significance, with the first woman on the seven member Federal Council executive being Elisabeth Kopp, who served from 1984–1989, and the first female president being Ruth Dreifuss in 1999
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Further references to Fleming's material can be found throughout the film; an MI6 safehouse is called "Hildebrand Rarities and Antiques", a reference to the short story "The Hildebrand Rarity" from the For Your Eyes Only short story collection. What is a reference to the long story "The Hildebrand Rarity"
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What is the portion of the island called that is protected from the sea by the island itself
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Buddhism traditionally incorporates states of meditative absorption (Pali: jhāna; Skt: dhyāna). The most acient yogic ideas is found in the early sermons of who?
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For example, opponents say affirmative action causes unprepared applicants to be accepted in highly demanding educational institutions or jobs which result in eventual failure (see, for example, Richard Sander's study of affirmative action in Law School, bar exam and eventual performance at law firms).
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Who approved the supplementary negative budget drafted by the Estonian government
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In the early stages of the First Punic War (264 BC) the first known Roman gladiatorial munus was held, described as a funeral blood-rite to the manes of a Roman military aristocrat. In what way was gladiatorial combat considered
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As reflected in the 2010 United States Census, Alaska has a total of 355 incorporated cities and census-designated places (CDPs). How many incorporated cities and CDPs does Alaska have, according to the 2012 Census?
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World Trade Center 2 was inaugurated in 2002, a twin tower of World Trade Center 1
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The poets generally associated with Cubism are Guillaume Apollinaire, Blaise Cendrars, Jean Cocteau, Max Jacob, André Salmon and Pierre Reverdy. What is the name of Wallace Steven's work that explains how cubism can be translated into poetry
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He accepted a crown as a "Rex Rusiae" ("King of Russia") from the Roman papacy, apparently doing so without breaking with Constantinople
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In practical terms, a computer program may be just a few instructions or extend to many millions of instructions, as do the programs for word processors and web browsers for example. A typical modern computer can execute billions of instructions per second (gigaflops) and rarely makes a mistake over many years of operation. Large computer programs consisting of several million instructions may take teams of programmers years to write, and due to the complexity of the task almost certainly contain errors.
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The watersheds divide at Triple Divide Peak in Glacier National Park
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What two addtional types of birds are listed in teh Encyclopedia Britanica as poultry
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Phillips became the winner, beating Sanchez. What former contestant did Ace Young ask to marry him
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Hundreds of movies have been shot or set in part within the city of Santa Monica. Who directed It's a Mad, Mad, Mad, World
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How many people did Wei Hong say were dead or missing
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The executive branch consists of the Governor, their staff, and other elected officials. Who commands the Oklahoma National Guard
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Livy presents these as signs of widespread failure in Roman religio. What author wrote of disaster prodigies
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The scope of the term "post-punk" has been subject to controversy. Who described post-punk as "a more adventurous and arty form of punk"
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What went hand and hand with military success?
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Part of the Russian resistance was credited[by whom?] to the deployment of newly invented blockade mines. Who named the torpedo mines
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What happens to a treaty that was designed to terminate under certain conditions when those conditions are actually met
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The period known as classical antiquity began with the rise of the city-states of Ancient Greece.
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Where is WHTV channel 81 based
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Medicine: Findings from Neolithic graveyards in what is now Pakistan show evidence of proto-dentistry among an early farming culture.
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1, 1945, p
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After working on various solo projects during 1988 (including Mercury's collaboration with Montserrat Caballé, Barcelona), the band released The Miracle in 1989. Which Queen album had more shared writing credits?
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A fundamental problem with software testing is that testing under all combinations of inputs and preconditions (initial state) is not feasible, even with a simple product. Defects that occur frequently are how easy to find
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Phillip Bard contributed to the theory with his work on animals. Who argued that an unemotional stimulus triggered experiential and physiological responses to emotions at the same time?
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What is it called when higher ups in government embezzle from the government's treasury
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The bureau's first official task was visiting and making surveys of the houses of prostitution in preparation for enforcing the "White Slave Traffic Act," or Mann Act, passed on June 25, 1910. What act was the bureau initially tasked with enforcing?
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In 2009 writer Geoff Boucher reflected that, "Superman and DC Comics instantly seemed like boring old Pat Boone; Marvel felt like The Beatles and the British Invasion.
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there is no penalty attached to the conference rate
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Sony's PlayStation 3 has extensive HD compatibility because of its built in Blu-ray disc based player, so does Microsoft's Xbox 360 with the addition of Netflix and Windows Media Center HTPC streaming capabilities, and the Zune marketplace where users can rent or purchase digital HD content. In addition to having a Blu-ray player the Xbox One also features what
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See British Double Summer Time and Central European Midsummer Time for details
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What was the name of the premium service that offered higher quality and DRM-free songs
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Where can Windows 8 install apps from?
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Many Northwestern alumni have used these productions as stepping stones to successful television and film careers
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The first Olympic games was recorded in what year?
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Where did the agreements that gave Napoleon time to structure his empire take place
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After the American Revolutionary War, the number and proportion of free people of color increased markedly in the North and the South as slaves were freed. How were the laws in New York abolished?
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Victoria's self-imposed isolation from the public diminished the popularity of the monarchy, and encouraged the growth of the republican movement. Where did Victoria visit after Leopold advised her to make more public appearances
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With an educational system made up of public school districts and independent private institutions, Oklahoma had 638,817 students enrolled in 1,845 public primary, secondary, and vocational schools in 533 school districts as of 2008[update]. What does Oklahoma spend per student in public schools as of 2008?
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Admiral Grace Hopper, an American computer scientist and developer of the first compiler, is credited for having first used the term "bugs" in computing after a dead moth was found shorting a relay in the Harvard Mark II computer in September 1947. When was Grace Hopper's Hardvard Mark II shorted by a moth
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The London Underground is the oldest underground railway network in the world
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71 AD), a half-brother to Emperor Ming of Han (r
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The Standard Elocutionist appeared in 168 British editions and sold over a quarter of a million copies in the United States alone
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Rotten Tomatoes sampled 274 reviews and judged 64% of the critiques to be positive, saying that the film "nudges Daniel Craig's rebooted Bond closer to the glorious, action-driven spectacle of earlier entries, although it's admittedly reliant on established 007 formula.
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Paleobotanists study ancient plants in the fossil record to provide information about the evolutionary history of plants
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A virtual ISP (VISP) is an operation that purchases services from another ISP, sometimes called a wholesale ISP in this context, which allow the VISP's customers to access the Internet using services and infrastructure owned and operated by the wholesale ISP. Who does an ISP purchase services from?
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He questioned the sincerity of Burke, who seemed to have forgotten the lessons he had learned from him, quoting from Burke's own speeches of fourteen and fifteen years before.
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Dannatt criticised a remnant "Cold War mentality", with military expenditures based on retaining a capability against a direct conventional strategic threat; He said currently only 10% of the MoD's equipment programme budget between 2003 and 2018 was to be invested in the "land environment"—at a time when Britain was engaged in land-based wars in Afghanistan and Iraq.
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In 1839, Melbourne resigned after Radicals and Tories (both of whom Victoria detested) voted against a bill to suspend the constitution of Jamaica. Who voted for the bill to end the constitution of Jamaica
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For example, specialized microvilli producing digestive enzymes may more likely be near the end of the midgut, and absorption near the origin or beginning of the midgut
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Who was the founder of the Roman Republic
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To what level is training for classical music often required?
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What must an operator deviate from to harm the computer?
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What did the state's policy not violate?
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In French lodges, for example, the line "As the means to be enlightened I search for the enlightened" was a part of their initiation rites.
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The Americans suffered 75,000 casualties on the ground; 94% of the Japanese soldiers died along with many civilians
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What do cultural sociologist tend to reject as key attribute of culture
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Once experiments with this system yielded successful results, the government officially sponsored it and encouraged peasants to use it
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Who did Algernon Sidney want to be tolerant towards?
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The Maratharas gained what over Rajputana?
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In what month did the system begin operations in Japan?
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How long is the prison term for the Chairman of the Supervisory Board?
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What famous ship left Southampton's port carrying the Pilgrim Fathers
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Speaking in St. What year was the goal for Russia's old carrier to achieve initial operational capability?
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In the 16th century, Count Hieronymus Schlick of Bohemia began minting coins known as Joachimstalers (from German thal, or nowadays usually Tal, "valley", cognate with "dale" in English), named for Joachimstal, the valley where the silver was mined (St. What is the modern name for Joachimsthal
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Malnutrition refers to insufficient, excessive, or imbalanced consumption of nutrients by an organism
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It can only be transformed
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The subsequent development of chain-termination DNA sequencing in 1977 by Frederick Sanger improved the efficiency of sequencing and turned it into a routine laboratory tool
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The direct object of the verb appears either in the accusative (for total objects) or in the partitive (for partial objects). Where can the direct object of the noun be found
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According to Hayek, what was the cause of the banks' wrongful allocation of funds
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The X-10 Graphite Reactor at Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee, formerly known as the Clinton Pile and X-10 Pile, was the world's second artificial nuclear reactor (after Enrico Fermi's Chicago Pile) and was the first reactor designed and built for continuous operation. Argonne National Laboratory's Experimental Breeder Reactor I, located at the Atomic Energy Commission's National Reactor Testing Station near Arco, Idaho, became the first nuclear reactor to create electricity on 20 December 1951. Initially, four 150-watt light bulbs were lit by the reactor, but improvements eventually enabled it to power the whole facility (later, the town of Arco became the first in the world to have all its electricity come from nuclear power generated by BORAX-III, another reactor designed and operated by Argonne National Laboratory). The world's first commercial scale nuclear power station, Obninsk in the Soviet Union, began generation with its reactor AM-1 on 27 June 1954. Other early nuclear power plants were Calder Hall in England, which began generation on 17 October 1956, and the Shippingport Atomic Power Station in Pennsylvania, which began on 26 May 1958. Nuclear power was used for the first time for propulsion by a submarine, the USS Nautilus, in 1954.
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In the century after the death of Osman I, Ottoman rule began to extend over the Eastern Mediterranean and the Balkans
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