knowledgator/bio-NER-relations · Datasets at Hugging Face

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DerSchmerz.00140351.eng.abstr	DerSchmerz.00140351.eng.abstr	[ { "id": "DerSchmerz.00140351.eng.abstr-passage-0", "type": "abstract", "text": [ "Background . Headaches are one of the most common health problems of children and adolescents , afflicting between 50-90% of the pediatric population in some form sometimes during their first two decades of life . Due to changing prevalence rates , more or less complex classification systems , inconsistent therapy responses with great inter- and intraindividual variabilities and high placebo response rates , pediatric headache syndromes are frequently thought to be too difficult for the outpatient evaluation and treatment in clinical practice ." ], "offsets": [ [ 0, 550 ] ] } ]	[ { "id": "DerSchmerz.00140351.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Headaches" ], "offsets": [ [ 13, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "health" ], "offsets": [ [ 50, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018684" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "children" ], "offsets": [ [ 69, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008059" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "adolescents" ], "offsets": [ [ 82, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001587" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "population" ], "offsets": [ [ 139, 149 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032659" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "life" ], "offsets": [ [ 207, 211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "prevalence" ], "offsets": [ [ 230, 240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220900" }, { "db_name": "UMLS", "db_id": "C0033105" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "classification" ], "offsets": [ [ 270, 284 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 308, 315 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "placebo" ], "offsets": [ [ 387, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "headache" ], "offsets": [ [ 422, 430 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 431, 440 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "outpatient" ], "offsets": [ [ 492, 502 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029921" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "evaluation" ], "offsets": [ [ 503, 513 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220825" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 518, 527 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "classification systems" ], "offsets": [ [ 270, 292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" } ] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-t11", "type": "umlsterm", "text": [ "headache syndromes" ], "offsets": [ [ 422, 440 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0752148" } ] } ]	[]	[]	[ { "id": "DerSchmerz.00140351.eng.abstr-s2-r1-t4.1-t6.1", "type": "isa", "arg1_id": "DerSchmerz.00140351.eng.abstr-s3-t4", "arg2_id": "DerSchmerz.00140351.eng.abstr-s3-t6", "normalized": [] }, { "id": "DerSchmerz.00140351.eng.abstr-s2-r2-t4.1-t2.1", "type": "isa", 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DerSchmerz.60100001.eng.abstr	DerSchmerz.60100001.eng.abstr	[ { "id": "DerSchmerz.60100001.eng.abstr-passage-0", "type": "abstract", "text": [ "Treatment of acute pain in children is a very important part of every doctor's work , and requires well-founded knowledge of this particular age group . Even in preterm infants pain apperception is fully developed , so that adequate analgesia is necessary . During infancy and childhood the individual developmental stage must be taken into account ; the ability to cope with pain often differs distinctly from that in adults . At the starting of an analgesic regimen nonsteroidal analgesics are sufficient in most cases . If pain is severe iv morphine should be used much more often in children , because it is very effective and side effects can be avoided . In contrast to chronic pain management , pain-dependent analgesic management can be considered as beneficial . Good knowledge of a small number of drugs with their pharmacological profile is sufficient for effective analgesic results even in severe pain states in children . Behavioural medicine should be integrated into paediatric pain management as soon as possible . An early start of pain reduction and prophylaxis is the best basis for development in the direction of competent pain coping behaviour in adult life ." ], "offsets": [ [ 0, 1182 ] ] } ]	[ { "id": "DerSchmerz.60100001.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Treatment" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 19, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "children" ], "offsets": [ [ 27, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008059" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "work" ], "offsets": [ [ 79, 83 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "knowledge" ], "offsets": [ [ 112, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376554" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 141, 144 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" }, { "db_name": "UMLS", "db_id": "C0001811" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "age group" ], "offsets": [ [ 141, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027362" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "infants" ], "offsets": [ [ 169, 176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021270" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 177, 181 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "analgesia" ], "offsets": [ [ 233, 242 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002766" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "stage" ], "offsets": [ [ 316, 321 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027646" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "ability" ], "offsets": [ [ 355, 362 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085732" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 376, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "adults" ], "offsets": [ [ 419, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001675" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "analgesic" ], "offsets": [ [ 450, 459 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "analgesics" ], "offsets": [ [ 481, 491 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 526, 530 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "morphine" ], "offsets": [ [ 544, 552 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026549" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "children" ], "offsets": [ [ 587, 595 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008059" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "side effects" ], "offsets": [ [ 631, 643 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001688" } ] }, { "id": "DerSchmerz.60100001.eng.abstr-s6-t1", "type": "umlsterm", "text": 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Some important experimental work focusing on additive and synergistic spinal interactions of 2-adrenoceptor agonists with opioids and some other agents are then discussed . Finally , there is a brief reference to the central role of the spinal cord in mediating and controlling nociception ." ], "offsets": [ [ 0, 993 ] ] } ]	[ { "id": "DerSchmerz.60100014.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "interactions" ], "offsets": [ [ 4, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037420" } ] }, { "id": "DerSchmerz.60100014.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "agonists" ], "offsets": [ [ 35, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243192" } ] }, { "id": "DerSchmerz.60100014.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "anaesthetics" ], "offsets": [ [ 49, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002932" } ] }, { "id": "DerSchmerz.60100014.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "analgesics" ], "offsets": [ [ 64, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.60100014.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "anaesthetics" ], "offsets": [ 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In addition , in children the combination of clonidine and bupivacaine for caudal anaesthesia resulted in a marked prolongation of postoperative pain relief . Circulatory effects of combined clonidine and local anaesthetics are the result of the specific spinal blockade and the central and peripheral effects of clonidine . The combined epidural and intrathecal administration of opioids and 2-adrenoceptor agonists provides better postoperative pain relief than the administration of either substance alone . In humans , the interaction seems to be additive rather than supra-additive . Because of its limited duration of action , continuous administration of clonidine is recommended , especially when it is used in combination with opioids . Neither the incidence nor the severity of side effects is increased by a combined therapy with opioids . Despite the sedative properties of clonidine , there is no increased risk of respiratory depression when clonidine is given in combination with opioids . The inhibiting effect on the sympathetic nervous system activity regularly observed during spinal administration of clonidine supports the value of this therapy and will support its use in the future . Therefore , the combination of 2-adrenoceptor agonists with local anaesthetics or opioids is reasonable and may improve anaesthetic practice ." ], "offsets": [ [ 0, 2048 ] ] } ]	[ { "id": "DerSchmerz.60100021.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "administration" ], "offsets": [ [ 31, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001554" } ] }, { "id": "DerSchmerz.60100021.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "agonists" ], "offsets": [ [ 64, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243192" } ] }, { "id": "DerSchmerz.60100021.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "anaesthetics" ], "offsets": [ [ 81, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002932" } ] }, { "id": "DerSchmerz.60100021.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "opioids" ], "offsets": [ [ 100, 107 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.60100021.eng.abstr-s1-t5", "type": "umlsterm", "text": [ 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The succeeding severe amnestic syndrome extinguished all recollection of the last 20 years , including the entire course of the painfull illness . The patient could then be mobilised without pain . Consistent care avoided a relapse into the pain syndrome as the amnestic syndrome gradually receded . The patient was fully able to accept responsibility and not longer required special pain therapy . The course demonstrates that chronic pain disorders of a predominantly psychodynamic , and therefore corticocerebral , genesis are dependent on an intact memory . In such cases memory failure can induce pain relief ." ], "offsets": [ [ 0, 1391 ] ] } ]	[ { "id": "DerSchmerz.60100036.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "female" ], "offsets": [ [ 14, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086287" }, { "db_name": "UMLS", "db_id": "C0015780" } ] }, { "id": "DerSchmerz.60100036.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 21, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100036.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 63, 67 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100036.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 68, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerSchmerz.60100036.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "period" ], "offsets": [ [ 84, 90 ] ], "normalized": [ { "db_name": 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DerSchmerz.60100040.eng.abstr	DerSchmerz.60100040.eng.abstr	[ { "id": "DerSchmerz.60100040.eng.abstr-passage-0", "type": "abstract", "text": [ "A patient with brachialgia was admitted to a surgical clinic and a cervical nerve block was performed under fluoroscopic guidance . Acute severe cervical pain prevented completion of the procedure . On the following day the patient developed incomplete paralysis of both legs and arms and was transferred to a neurosurgical department for further diagnosis and therapy . The CT scan showed a space-occupying cervical intraspinal haematoma , which was removed immediately as far as possible by a dorsal approach . Postoperatively little improvement of neurologic function was noticed , and 11 days after the event the patient died from a massive pulmonary embolism despite intense resuscitation efforts ." ], "offsets": [ [ 0, 703 ] ] } ]	[ { "id": "DerSchmerz.60100040.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 2, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 45, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 76, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "nerve block" ], "offsets": [ [ 76, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027741" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 154, 158 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "procedure" ], "offsets": [ [ 187, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "cervical pain" ], "offsets": [ [ 145, 158 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007859" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 224, 231 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "paralysis" ], "offsets": [ [ 253, 262 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030440" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "legs" ], "offsets": [ [ 271, 275 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "arms" ], "offsets": [ [ 280, 284 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003792" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 347, 356 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 361, 368 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "haematoma" ], "offsets": [ [ 429, 438 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018944" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "CT scan" ], "offsets": [ [ 375, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040405" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "function" ], "offsets": [ [ 562, 570 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031843" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 617, 624 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "embolism" ], "offsets": [ [ 655, 663 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013922" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "resuscitation" ], "offsets": [ [ 680, 693 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035273" } ] }, { "id": "DerSchmerz.60100040.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "efforts" ], "offsets": [ [ 694, 701 ] ], "normalized": [ { "db_name": 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As measures of general psychological dysfunction the ADS for the assessment of depression and the B-L , a symptom checklist , are suggested as instruments suitable for routine use in diagnosis and evaluation ." ], "offsets": [ [ 0, 1007 ] ] } ]	[ { "id": "DerSchmerz.60100047.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "inventories" ], "offsets": [ [ 22, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031213" }, { "db_name": "UMLS", "db_id": "C0021941" } ] }, { "id": "DerSchmerz.60100047.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "instruments" ], "offsets": [ [ 42, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243113" } ] }, { "id": "DerSchmerz.60100047.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 62, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "DerSchmerz.60100047.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 76, 80 ] ], "normalized": [ { "db_name": "UMLS", 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DerSchmerz.60100065.eng.abstr	DerSchmerz.60100065.eng.abstr	[ { "id": "DerSchmerz.60100065.eng.abstr-passage-0", "type": "abstract", "text": [ "The antinociceptive effect of 2-adrenoceptor agonists is mediated by activation of descending inhibiting noradrenergic systems , which modulates ' wide-dynamic-range' neurones . Furthermore , they inhibit the liberation of substance P and endorphines and activate serotoninergic neurones . Despite this variety of antinociceptive actions , there is still little experience with 2-adrenoceptor agonists as therapeutic agents for use in chronic pain syndromes . Studies in animals and patients have shown that the transdermal , epidural and intravenous administration of the 2-adrenoceptor agonist clonidine reduces pain intensity in neuropathic pain syndromes for periods varying from some hours up to 1 month . Patients suffering from lancinating or sharp pain respond best to this therapy . Topically applied clonidine ( 200-300 µg) relieves hyperalgesia in sympathetically maintained pain . Epidural administration of 300 µg clonidine dissolved in 5 ml NaCl 0.9 % has also been shown to be effective . In patients suffering from cancer pain tolerant to opioids , pain control has proved possible again with combinations of opioids and clonidine . In isolated cases clonidine has been administered epidurally at a dose of 1500 µg/day for almost 5 months without evidence for any histotoxic property of clonidine . Side effects often observed during administration of 2-adrenoceptor agonists are dry mouth , sedation , hypotension and bradycardia . Therapeutic interventions are usually not required ." ], "offsets": [ [ 0, 1501 ] ] } ]	[ { "id": "DerSchmerz.60100065.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "agonists" ], "offsets": [ [ 45, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243192" } ] }, { "id": "DerSchmerz.60100065.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "noradrenergic" ], "offsets": [ [ 105, 118 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013089" } ] }, { "id": "DerSchmerz.60100065.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "neurones" ], "offsets": [ [ 167, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027882" } ] }, { "id": "DerSchmerz.60100065.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "neurones" ], "offsets": [ [ 279, 287 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027882" } ] }, { "id": "DerSchmerz.60100065.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "substance P" ], "offsets": [ [ 223, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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DerSchmerz.60100071.eng.abstr	DerSchmerz.60100071.eng.abstr	[ { "id": "DerSchmerz.60100071.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction . The relationship between depression and the outcome of low back surgery was investigated . Data analysis was based on two assumptions : ( 1 ) Presurgical assessments of depression are correlated with the outcome of surgery , and , therefore , depression can be interpreted as a risk factor for surgical failure . ( 2 ) Postsurgical assessments of depression are correlated with the outcome of surgery , and therefore , depression can be interpreted as a response to treatment failure . Methods . The sample was made up of 78 patients who had undergone lumbar nucleotomy and 132 patients with lumbar spondylodesis . Treatment outcome was evaluated 6 months after surgery in the nucleotomy group and 9 months after surgery in the spondylodesis group . Depression was assessed with the Beck Depression Inventory ( BDI ) . Measures of treatment outcome were an objective rating system for the surgical result , functional impairment , return to work , subjective estimations of the patient , and pain intensity . Results . Presurgical depression scores showed no significant relationship with surgical outcome in nucleotomy patients . In spondylodesis patients , however , there was a significant negative correlation with the patients ' subjective outcome ratings . Postsurgical depression scores , on the other hand , were significantly related to almost all of the outcome variables in both treatment groups . Patients with clinically relevant postsurgical depression scores were significantly more likely not to benefit sufficiently from surgery than those with clinically not relevant depression scores . Discussion . Our findings favour assumption 2 over assumption . 1. In the light of our findings , depressiveness is interpreted as a response to a non-beneficial outcome of surgery . The need for an interdisciplinary approach combining psychological counseling or treatment and physical therapy for those patients who do not benefit from surgery is discussed ." ], "offsets": [ [ 0, 1981 ] ] } ]	[ { "id": "DerSchmerz.60100071.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "depression" ], "offsets": [ [ 40, 50 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011570" } ] }, { "id": "DerSchmerz.60100071.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "back" ], "offsets": [ [ 74, 78 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004600" } ] }, { "id": "DerSchmerz.60100071.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 79, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerSchmerz.60100071.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "analysis" ], "offsets": [ [ 111, 119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": 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], "normalized": [ { "db_name": "UMLS", "db_id": "C0027552" } ] }, { "id": "DerSchmerz.60100071.eng.abstr-s18-t2", "type": "umlsterm", "text": [ "counseling" ], "offsets": [ [ 1871, 1881 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010210" } ] }, { "id": "DerSchmerz.60100071.eng.abstr-s18-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1885, 1894 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100071.eng.abstr-s18-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 1908, 1915 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100071.eng.abstr-s18-t5", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 1926, 1934 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100071.eng.abstr-s18-t6", "type": "umlsterm", "text": [ "surgery" ], 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DerSchmerz.60100080.eng.abstr	DerSchmerz.60100080.eng.abstr	[ { "id": "DerSchmerz.60100080.eng.abstr-passage-0", "type": "abstract", "text": [ "Aims . Severe pain of mucositis induced by cytostatic conditioning therapy in bone marrow transplantation ( BMT ) patients generally requires continuous parenteral opioid treatment . Cognitive and psychological disturbances are frequent complications subsequent to BMT and may result from cerebral opioid side effects . The aim of the study was to evaluate the efficiency of continuous morphine in mucositis pain and the side-effects in BMT patients . Particular emphasis was placed on the question of whether reaction times , which are usually measured to estimate opioid effects upon vigilance , are influenced by pain-induced cognitive impairments in pain patients . Methods While in hospital , 10 BMT patients were examined daily with the aid of a mucositis scale , subjective visual analog scales ( VAS ) for pain and mood parameters , a German version of the McGill pain questionnaire ( MPQ ) , and a mental performance task battery , and the morphine given was documented . Mental performance tests were simple auditory reaction time and choice reaction time . Seven patients also performed a Sternberg memory search test in which they had to use ' yes ' and ' no ' response keys to match visually presented test letters to a previously memorized set of letters . Practice and baseline data were collected within the first week before BMT . Results The intensity and duration of mucositis differed from patient to patient , resulting in different pain intensities and MPQ scores . Prolongation of the choice reaction time averaged over the period of mucositis treatment correlated significantly with residual pain intensity ( Spearman rs = 0.88 , p 0.01 ) but not with morphine dose ( rs = 0.35 , p = 0.33 ) . For the Sternberg memory search test greater correlation coefficients resulted between reaction time and morphine dose ( rs = 0.86 , p = 0.014 ) than between reaction time and residual pain intensity ( rs = 0.61 , p = 0.15 ) . In turn , pain intensity , unlike morphine dose , was significantly correlated with high scores in the mood parameters for depression , passivity , and tiredness . Conclusions It is concluded that both pain and morphine can impair cognitive performance , but that these mental stressors seem to differ according to qualitative criteria . Whereas pain might slow reaction time by distracting a patient's attention , particularly in low mental demand tasks , morphine could interfere with more specific cognitive processes , such as short-term memory operations , that are required in more complex tasks ." ], "offsets": [ [ 0, 2547 ] ] } ]	[ { "id": "DerSchmerz.60100080.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 14, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "cytostatic" ], "offsets": [ [ 43, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010858" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "conditioning" ], "offsets": [ [ 54, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009647" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 67, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "bone" ], "offsets": [ [ 78, 82 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0262950" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "marrow" ], "offsets": [ [ 83, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376152" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "transplantation" ], "offsets": [ [ 90, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029216" }, { "db_name": "UMLS", "db_id": "C0040732" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "BMT" ], "offsets": [ [ 108, 111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005961" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 114, 122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "opioid" ], "offsets": [ [ 164, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 171, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "conditioning therapy" ], "offsets": [ [ 54, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004933" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t13", "type": "umlsterm", "text": [ "bone marrow" ], "offsets": [ [ 78, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005953" } ] }, { "id": "DerSchmerz.60100080.eng.abstr-s2-t14", "type": "umlsterm", "text": [ "bone marrow transplantation" ], "offsets": [ [ 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DerSchmerz.60100089.eng.abstr	DerSchmerz.60100089.eng.abstr	[ { "id": "DerSchmerz.60100089.eng.abstr-passage-0", "type": "abstract", "text": [ "Utilizing MEDLINE and PSYCLIT , a search for articles covering psychological research on pain in the Western European countries was undertaken for the period from 1 January 1990 to 31 December 1994. A total of 398 publications were identified , of which 44 were classified as experimental research in the laboratory , 33 as psychodiagnostic and 225 as clinical studies . The most frequent diagnosis was back pain , followed by musculoskeletal pain and headache . With regard to the total number of publications , Germany was first , followed by The Netherlands and Great Britain . In an analysis of the subcategories , the leading position of Germany could only be confirmed with respect to laboratory studies ; in psychodiagnostic publications , Germany fell back behind Great Britain and The Netherlands . In clinical studies , Germany was second to Sweden . Relating the number of publications to the number of personnel estimated to be engaged in research , The Netherlands and the Scandinavian countries demonstrate very high efficiency . Compared with Germany , these countries facilitate the integration of psychological procedures into an interdisciplinary management of pain ." ], "offsets": [ [ 0, 1185 ] ] } ]	[ { "id": "DerSchmerz.60100089.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "MEDLINE" ], "offsets": [ [ 10, 17 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025141" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "research" ], "offsets": [ [ 77, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 89, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "period" ], "offsets": [ [ 151, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025344" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "publications" ], 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"normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 443, 447 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "headache" ], "offsets": [ [ 452, 460 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "back pain" ], "offsets": [ [ 403, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004604" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "publications" ], "offsets": [ [ 498, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034036" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 513, 520 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": 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"C0027778" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "efficiency" ], "offsets": [ [ 1031, 1041 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013682" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "Scandinavian countries" ], "offsets": [ [ 986, 1008 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036273" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 1058, 1065 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 1128, 1138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1179, 1183 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] 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DerSchmerz.60100093.eng.abstr	DerSchmerz.60100093.eng.abstr	[ { "id": "DerSchmerz.60100093.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the present study was to examine the value of the sympathetic skin response ( SSR ) in the diagnosis of reflex sympathetic dystrophy ( RSD ) ." ], "offsets": [ [ 0, 153 ] ] } ]	[ { "id": "DerSchmerz.60100093.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "aim" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0108800" } ] }, { "id": "DerSchmerz.60100093.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "value" ], "offsets": [ [ 48, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "DerSchmerz.60100093.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "skin" ], "offsets": [ [ 73, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "DerSchmerz.60100093.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 102, 111 ] ], "normalized": 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DerSchmerz.60100121.eng.abstr	DerSchmerz.60100121.eng.abstr	[ { "id": "DerSchmerz.60100121.eng.abstr-passage-0", "type": "abstract", "text": [ "Stimulating afferent fibers of the trigeminal nerve usually causes two successive suppressions ( ES1 and ES2) of the voluntary muscle activity of chewing muscles . The first phase of decreased voluntary activity is called the early exteroceptive suppression period ( ES1); the second phase is called the late exteroceptive suppression period ( ES2). Between these two suppression periods is a phase of increased muscle activity , the so-called facilitation period ( FP ) . Usually , in healthy subjects this normal pattern of exteroceptive suppression can be elicited regularly . The reflex answer may occur at low non-painful stimulus intensities ; however , typically it appears to be most pronounced with high-intensity stimuli . Because of the obvious relationship between stimulus intensity , pain perception and reflex answer , the reflex is regarded as an antinociceptive reaction . Chronic pain syndromes like chronic tension-type headache and migraine without aura cause changes within the normal ES recording pattern . Furthermore , some substances used in pain therapy such as serotoninagonists or antagonists , acetylsalicylic acid or naloxon may also alter the general appearance of the ES . In this review different parameters that influence the ES reflex answer are summarized . Above , the diagnostic value of the changes of the ES for pathophysiological procedures regarding pain perception and pain processing in certain pain diseases is discussed ." ], "offsets": [ [ 0, 1467 ] ] } ]	[ { "id": "DerSchmerz.60100121.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 46, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "muscle" ], "offsets": [ [ 127, 133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "muscles" ], "offsets": [ [ 154, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "trigeminal nerve" ], "offsets": [ [ 35, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040996" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s1-t5", "type": 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DerSchmerz.60100135.eng.abstr	DerSchmerz.60100135.eng.abstr	[ { "id": "DerSchmerz.60100135.eng.abstr-passage-0", "type": "abstract", "text": [ "First time experienced severe headache combined with fever or meningism requires immediate evaluation by computer tomography ( CT ) to exclude subarachnoidal or cerebral hemorrhage , hydrocephalus or a tumor . If CT is normal , lumbar puncture must be performed to exclude meningitis and meningoencephalitis . Chronic or chronic recurrent headache without focal neurological deficits does not require EEG or CT . CT must be performed if the headache characteristics change or if the headache is combined with neurological deficits ." ], "offsets": [ [ 0, 532 ] ] } ]	[ { "id": "DerSchmerz.60100135.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 6, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "headache" ], "offsets": [ [ 30, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "fever" ], "offsets": [ [ 53, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015967" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "meningism" ], "offsets": [ [ 62, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025287" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "evaluation" ], "offsets": [ [ 91, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220825" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "computer" ], "offsets": [ [ 105, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009622" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "tomography" ], "offsets": [ [ 114, 124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040395" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "hemorrhage" ], "offsets": [ [ 170, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019080" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "hydrocephalus" ], "offsets": [ [ 183, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020255" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 202, 207 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "cerebral hemorrhage" ], "offsets": [ [ 161, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007784" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "puncture" ], "offsets": [ [ 235, 243 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034117" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "meningitis" ], "offsets": [ [ 273, 283 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025289" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "meningoencephalitis" ], "offsets": [ [ 288, 307 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025309" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "lumbar puncture" ], "offsets": [ [ 228, 243 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037943" } ] }, { "id": "DerSchmerz.60100135.eng.abstr-s3-t1", "type": 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DerSchmerz.60100140.eng.abstr	DerSchmerz.60100140.eng.abstr	[ { "id": "DerSchmerz.60100140.eng.abstr-passage-0", "type": "abstract", "text": [ "Whether the primary mechanisms of migraine are vascular or neurogenic is , as yet unresolved . Early studies using Doppler sonography prompted heterogeneous results , mainly due to methodological differences . However , blood flow measurements using single photon emission tomography ( SPECT ) or positron emission tomography ( PET ) have not revealed any differences in cerebral blood flow in migraine without aura . Moreover , specific migraine compounds do not alter cortical blood flow . During attacks , increased blood flow is found in the cerebral hemispheres in cingulate , auditory and visual association cortices and the brain stem . Alltogether , these findings suggest that the pathogenesis of migraine is related to an imbalance in activity between brain stem nuclei regulating antinociception and vascular control , rather than in primary vessel diameter changes ." ], "offsets": [ [ 0, 878 ] ] } ]	[ { "id": "DerSchmerz.60100140.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 34, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "sonography" ], "offsets": [ [ 123, 133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041618" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 220, 225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "measurements" 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"C0032744" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "tomography" ], "offsets": [ [ 315, 325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040395" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "PET" ], "offsets": [ [ 328, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031268" }, { "db_name": "UMLS", "db_id": "C0032743" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 380, 385 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s3-t11", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 394, 402 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s3-t12", "type": "umlsterm", "text": [ "aura" ], "offsets": [ [ 411, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0236018" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s3-t13", "type": "umlsterm", "text": [ "positron emission tomography" ], "offsets": [ [ 297, 325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032743" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s3-t14", "type": "umlsterm", "text": [ "migraine without aura" ], "offsets": [ [ 394, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0338480" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 438, 446 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 479, 484 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "DerSchmerz.60100140.eng.abstr-s5-t1", "type": "umlsterm", "text": [ 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DerSchmerz.60100146.eng.abstr	DerSchmerz.60100146.eng.abstr	[ { "id": "DerSchmerz.60100146.eng.abstr-passage-0", "type": "abstract", "text": [ "A menstrual migraine occurs in approximately 7-10 % of women suffering from migraine . The migraine occurs from 2 days before until 3 days after the end of the menstrual period . The choice of treatment depends on the duration of the attack , which ranges from 3 to 7 days . An attack of up to 3 days duration should be treated with acetylsalicylic acid , ergotamine tartrate or naproxen , each in combination with an antiemetic ( domperidone , metoclopramide ) . If there is no response , sumatriptan can be administered orally ( 25-100 mg ) or subcutaneously ( 6 mg ) . In the attacks continue for more than 3 days , short-term prophylaxis with naproxen or the application of an estrogen-containing patch is indicated . Neither ovulation inhibitors nor traditional migraine prophylaxis has an influence on menstrual migraine . Patients should keep a headache diary . Short-term prophylaxis with ergotamine tartrate or tamoxifen is obsolete ." ], "offsets": [ [ 0, 943 ] ] } ]	[ { "id": "DerSchmerz.60100146.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 12, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 55, 60 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 76, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 91, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "period" ], "offsets": [ [ 170, 176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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DerSchmerz.60100149.eng.abstr	DerSchmerz.60100149.eng.abstr	[ { "id": "DerSchmerz.60100149.eng.abstr-passage-0", "type": "abstract", "text": [ "Acupuncture is now being increasingly used in the treatment of headache . Acupuncture is a technique originating in Asia , from countries that have a cultural background with a fundamentally different concept of disease and therapy . Up to now , sustained application of acupuncture in Western medicine has been impeded by the lack of a scientifically convincing explanation of the mechanisms of action in terms of neurobiological criteria . Acupuncture is being used empirically in the treatment of migraine ; clinical studies have been published . A definitive evaluation of acupuncture based on well-founded clinical experimental studies has yet to be made . The investigation was carried out in migraine patients who were divided into two subgroups in a control group design with two different stimulation techniques . The verum group was treated with the correct point location , normal prick depth and elicitation of a needle sensation . The control group received treatment at points that are far away from the acupuncture points , using a superficial prick technique and without eliciting a needle sensation . The effect of therapy was appraised by means of headache diaries with subsequent interference statistical and individual case analysis . In the present study comprising 81 patients , the incidence of the attacks was significantly reduced in both subgroups . The effect of acupuncture treatment was of comparable magnitude to that of the beta-blocker metoprolol . The advantage of acupuncture treatment consists in the lack of side effects such as gastrointestinal symptoms or an increase in weight . A minor side effect was only reported in one case . In the data analysis with the interference statistical method , verum acupuncture was superior to the control in only one subgroup . The possibility that the addition of further points ( distant points ) can explain this effect on the basis of the hypothesis of a central modulation of the migraine process is discussed . Acupuncture shows a sufficiently pronounced and sustained therapeutic effect for its use to be considered in a possible interval treatment of migraine ." ], "offsets": [ [ 0, 2144 ] ] } ]	[ { "id": "DerSchmerz.60100149.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Acupuncture" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.60100149.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 50, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100149.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "headache" ], "offsets": [ [ 63, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.60100149.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Acupuncture" ], "offsets": [ [ 74, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": 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DerSchmerz.60100156.eng.abstr	DerSchmerz.60100156.eng.abstr	[ { "id": "DerSchmerz.60100156.eng.abstr-passage-0", "type": "abstract", "text": [ "Homeopathy as an alternative to conventional therapy is becoming increasingly popular . Although interest is rising , little is known about the real effectiveness of homeopathic therapy in headaches . Three studies addressing this question are discussed : an Italian migraine study , the London migraine study and our own , the Munich headache trial . While the first one reported very high effects , the best ones known in the literature , the results of the other two trials do not endorse this first finding . The London trial did not show any effect other than placebo , although a different time trend was reported . The Munich study failed to show any difference between homeopathy and placebo whatsoever . The merits and shortcomings of these studies are discussed . At present , we do not have any evidence that homeopathic therapy has any effect other than a placebo effect . However , this can be very impressive sometimes . We do not know which variables are correlated with placebo effectiveness , and we do not have any data on real-type homeopathy outside a trial setting , as there are no data available ." ], "offsets": [ [ 0, 1120 ] ] } ]	[ { "id": "DerSchmerz.60100156.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Homeopathy" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019867" }, { "db_name": "UMLS", "db_id": "C0684199" } ] }, { "id": "DerSchmerz.60100156.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 45, 52 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100156.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 178, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100156.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "headaches" ], 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C. ) , Celsus ( 1st century A. D. ) , and the famous experimental physiologist Galen ( 2nd century A. D. ) agreed that pain was a sign of evil which should be fought without exception . It was Galen who added the disturbance of function ( functio laesa ) as the fifth cardinal sign of inflammation to the four well-known cardinal signs of Celsus ( rubor , calor , tumor , dolor ) . He also coined the term µK to characterize an attack of migraine . In algotherapy , Galen used a complex pharmacological system which was based upon the four cardinal qualities of humoral pathology . On the other hand , pain was designed as a multi-dimensional symbol by the famous Graeco-Roman epic poets . In Homer's Odyssey ( 8th century B. C. ) , pain appears transformed into the shape of a scar which is visible and palpable on the hero's leg like an identification tag , whereas in Virgil's Aeneids ( 1st century B. 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However , evidence suggesting that effective postoperative analgesia can significantly improve postoperative morbidity in patients at risk is accumulating . In such patients , combined use of epidural local anaesthetics and opioids may become the technique of choice for postoperative analgesia . However , there is no evidence that this would have any clinically relevant benefit in low-risk patients ." ], "offsets": [ [ 0, 1217 ] ] } ]	[ { "id": "DerSchmerz.60100176.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "opioids" ], "offsets": [ [ 7, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.60100176.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "analgesics" ], "offsets": [ [ 29, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.60100176.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 44, 52 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerSchmerz.60100176.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "non-surgical" ], "offsets": [ [ 57, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerSchmerz.60100176.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 70, 74 ] ], 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DerSchmerz.60100190.eng.abstr	DerSchmerz.60100190.eng.abstr	[ { "id": "DerSchmerz.60100190.eng.abstr-passage-0", "type": "abstract", "text": [ "A multimodal treatment program is presented in cases of functional restoration for chronic low back pain . The study comprises four parts . Part I gives an overview of the different results of the study . Part II focuses on the medical and functional examination in comparison with persons who do not suffer from back pain . Part III describes psychosocial aspects ( depression , complaints , ways of coping , disability ) and psychotherapy . In part IV prognostic factors and their reliability for predicting treatment outcome ( return to work , pain intensity , self-assessment of success by patients ) are examined . In addition the relevant effects of the program on social and health care systems are also addressed . Problem The incidence of low back pain is continuously increasing , causing tremendous costs for the health insurance system . Therefore effective treatment methods are needed that take into account somatic , psychological and social factors . Chronic low back pain is conceptualized as a complex phenomenon including biological , social and psychological aspects , all of which should be addressed in a treatment program . A multimodal treatment program for chronic low back pain is presented , in which physical activity and cooperation of the patient are the primary targets . Therapeutic aims focus less on pain reduction and emphasize instead pain control , individual responsibility of the patient , and early reintegration into the working environment . The specific goals of the program are to increase the physical abilities of the patients ( i . e . , flexibility , strength and endurance ) , to increase patients ' knowledge and the use of body mechanics and back protection techniques , to decrease medication-intake , to decrease dependency on the medical community , to improve patients ' own positive coping skills and levels of emotional control , to increase the patient's activity level at home and to facilitate a return to work . Methods A total of 90 disabled patients with chronic low back pain were admitted to an 8-week program of functional restoration and behavioral support . The program consisted of a pre-program ( 3 weeks : education , stretching and calisthenic exercises ) and an intensive treatment period ( aerobics , functional strength and endurance exercises , back exercises , cognitive behavioral group therapy , relaxation training , socioeconomic and vocational counseling ) which took place for 5 weeks , 7 h a day , on an outpatient basis . Apart from a medical examination and a personal interview , the patients ' physical impairment , pain descriptions , and psychological distress ( according to different criteria for evaluation ) were also measured . This includes variables such as depression , psychovegetative complaints , quality of life and workplace satisfaction , disability , and coping with disease . Measurements were repeated at the end of the 8-week program , and after 6 and 12 months . Results In total 84 patients ( 94 % ) were examined following treatment . There was a statistically significant improvement in flexibility , strength , lifting capacity , and endurance measurements ( p 0.001 ) at the end of the treatment . In addition , significant reductions in pain , disability , depression , and psychovegetative signs were demonstrated ( p 0.001 ) . There was a decreased use of medical treatment for back pain following the program , with 42 % of the patients refraining from the intake of analgesics , followed by a significant reduction in physiotherapy and the consultation of physicians . Assessment of the patients ' reported increased activity levels at home also supported findings that statistical improvements were significant . Sixty-three percent of the patients were found to have returned to active , productive work following discharge from the program . Most of the improvements remained stable at the 6- and 12-month follow-up examinations . Conclusion The results demonstrate the effect ." ], "offsets": [ [ 0, 4000 ] ] } ]	[ { "id": "DerSchmerz.60100190.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 13, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100190.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "program" ], "offsets": [ [ 23, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376691" } ] }, { "id": "DerSchmerz.60100190.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "back" ], "offsets": [ [ 95, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004600" } ] }, { "id": "DerSchmerz.60100190.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 100, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100190.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "multimodal treatment" ], "offsets": [ [ 2, 22 ] ], "normalized": [ { 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], "normalized": [ { "db_name": "UMLS", "db_id": "C0376706" } ] }, { "id": "DerSchmerz.60100190.eng.abstr-s15-t6", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 1709, 1719 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.60100190.eng.abstr-s15-t7", "type": "umlsterm", "text": [ "medication-intake" ], "offsets": [ [ 1734, 1751 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.60100190.eng.abstr-s15-t8", "type": "umlsterm", "text": [ "dependency" ], "offsets": [ [ 1766, 1776 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011546" } ] }, { "id": "DerSchmerz.60100190.eng.abstr-s15-t9", "type": "umlsterm", "text": [ "community" ], "offsets": [ [ 1792, 1801 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009462" } ] }, { "id": "DerSchmerz.60100190.eng.abstr-s15-t10", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 1815, 1823 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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DerSchmerz.60100237.eng.abstr	DerSchmerz.60100237.eng.abstr	[ { "id": "DerSchmerz.60100237.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem There is a great need to expand current knowledge of the various functional capacity measurements used in the rehabilitation of chronic low back pain ( CLBP ) patients . The literature on these patients reports that mobility , endurance , trunk strength and lifting capacity decrease during the process of chronicity . Chronically disabled patients appear to have lower functional capacity than asymptomatic persons . Methods Our study group consisted of 90 disabled CLBP patients ( 44 female , 46 male ; average age 42 years ) who underwent a multidisciplinary 8-week daily treatment program of functional restoration with behavioral support ( instruction , endurance training , strength exercises , behavioral and treatment to facilitate return to work therapy ) . Initially these patients where compared with 107 asymptomatic persons ( 44 female , 63 male , average age 41 years ) . The patients were investigated before and after treatment , and at intervals of 6 and 12 months . The reliability of the functional measurements was evaluated by interrater comparison . Physical assessment included a medical examination ( mainly diagnosis of radicular or nonradicular pain ) , changes in the lumbar spine revealed by X-ray studies according to Herron and Turner [ 50 ] , rating of physical impairment according to Waddell [ 117 ] , flexibility , length of hamstrings muscles ( SLR ) , test of power and endurance of trunk movement by standardized exercises according to the Swiss group of Spring [ 102 ] and isokinetic measurements ( LIDO Back ) , tests of lifting capacity ( LIDO Lift ) , and ( in part ) of general endurance on a cycle ergometer ( CASE 15 Marquette ) . Results Physical findings showed that mobility was reduced substantially in patients suffering from back pain due to reduced SLR ( shortened hamstrings ) and decreased spinal mobility . Patients also demonstrated significant reductions in their ability to perform lifting tasks in comparison to healthy individuals . The results of trunk flexion showed no significant differences between patients and the control group , whereas the ability to perform trunk extension was much better in the control group . In principle we found the same results with isokinetic measurements as in the exercises without machines . Cardiovascular endurance was also much better in the control group than it was in the back pain patients . At the end of the treatment program all physical deficits were improved significantly . In many cases performance was comparable with that of the control group . With time , however , training effects gradually decreased . The success of treatment ( return to work , absence from work , pain reduction , use of medical care ) was independent of the functional status of the patients before and after treatment . Conclusion Study results showed that physical capacity in disabled patients with low back pain is substantially reduced in comparison to persons who do not suffer from back pain . The only exception was in trunk flexor strength and endurance , in which measurements did not differ between the patients and the control group . However , even CLBP- patients with long-term pain and severe physical illness can successfully improve their physical condition by participating in an active treatment program . Back extensor muscle training has to be included in physical therapy . Because of loss of condition during the time after treatment , regular monitoring of patients and their home training programs is necessary . 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DerSchmerz.60100254.eng.abstr	DerSchmerz.60100254.eng.abstr	[ { "id": "DerSchmerz.60100254.eng.abstr-passage-0", "type": "abstract", "text": [ "Tramadol , a mixed µ-opioid agonist and a monoamine-reuptake blocking analgesic , has been supposed to have little effect on propulsive gastrointestinal motility . However , this has not been specifically studied in man . Following institutional approval , 18 human volunteers were given 50 mg of tramadol , tilidine/naloxone , and codeine , respectively , in a double-blind randomised cross-over design . Additionally , 12 further volunteers were given 100 mg of each opioid in a double-blind , randomised fashion , followed by measurement of gastrocoecal transit time . Gastrointestinal transit time was measured using the lactulose H2-breath test . A threefold increase in end-expiratory hydrogen when compared to the control value was considered the end point of gastrocoecal transit . At the low dose ( 50 mg ) the three opioids did not differ significantly with regard to their effect on gastrointestinal motility . Gastrocoecal transit time was 90.8 ( +/- 10.1 SEM ) min for tramadol , 100.6 ( +/- 9.8 SEM ) min for tilidine/naloxone , and 104.2 ( +/- 8.7 SEM ) min for codeine . Doubling the dose of each opioid resulted in an increase in mean gastrocoecal transit , namely 97.8 ( +/- 11.2 SEM ) min for tramadol , 129.2 ( +/- 12.2 SEM ) min for tilidine/naloxone and 135.9 ( +/- 9.2 SEM ) min for codeine . The increase in gastrocoecal transit time was significant ( P 0.01 ) for high doses of tilidine/naloxone and codeine in contrast to the effect of the low doses . This lesser constipation effect may be due to the reduced affinity of tramadol to the µ-opioid receptor . Sedation was significantly higher for codeine after 50 mg ( P 0.05 ) and 100 mg ( P 0.005 ) than for tilidine/naloxone and tramadol . Vertigo was significantly higher after 50 mg ( P 0.05 ) and 100 mg ( P 0.005 ) of tilidine/naloxone and codeine than after tramadol . Perspiration was significantly higher after tramadol 100 mg ( P 0.005 ) than after tilidine/naloxone and codeine . Sedation is considered a typical symptom of analgesics interacting with centrally located opioid receptor sites . The higher incidence of perspiration after tramadol suggests that monominergic pathways may be involved in thermoregulation . In conclusion , the opioids tilidine/naloxone and codeine at the doses used significantly prolong gastrointestinal transit time in the high-dose range . Since tramadol does not induce a dose-related increase in gastrocoecal transit time , it may be a useful analgesic in patients who are prone to developing constipation during high-dose opioid therapy ." ], "offsets": [ [ 0, 2561 ] ] } ]	[ { "id": "DerSchmerz.60100254.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Tramadol" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040610" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "agonist" ], "offsets": [ [ 28, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243192" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "analgesic" ], "offsets": [ [ 70, 79 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "gastrointestinal motility" ], "offsets": [ [ 136, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017184" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "man" ], "offsets": [ [ 216, 219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" }, { "db_name": "UMLS", "db_id": "C0024554" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "human" ], "offsets": [ [ 260, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "volunteers" ], "offsets": [ [ 266, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042960" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "tramadol" ], "offsets": [ [ 297, 305 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040610" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "codeine" ], "offsets": [ [ 332, 339 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009214" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "human volunteers" ], "offsets": [ [ 260, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020155" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "cross-over design" ], "offsets": [ [ 386, 403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242817" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "volunteers" ], "offsets": [ [ 432, 442 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042960" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "opioid" ], "offsets": [ [ 469, 475 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "measurement" ], "offsets": [ [ 529, 540 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242485" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 565, 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"db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s10-t2", "type": "umlsterm", "text": [ "codeine" ], "offsets": [ [ 1425, 1432 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009214" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s10-t3", "type": "umlsterm", "text": [ "contrast" ], "offsets": [ [ 1436, 1444 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0110625" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s11-t1", "type": "umlsterm", "text": [ "constipation" ], "offsets": [ [ 1490, 1502 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009806" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s11-t2", "type": "umlsterm", "text": [ "tramadol" ], "offsets": [ [ 1548, 1556 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040610" } ] }, { "id": "DerSchmerz.60100254.eng.abstr-s12-t1", "type": "umlsterm", "text": [ "codeine" ], "offsets": [ [ 1622, 1629 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009214" } ] }, { "id": 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DerSchmerz.60100261.eng.abstr	DerSchmerz.60100261.eng.abstr	[ { "id": "DerSchmerz.60100261.eng.abstr-passage-0", "type": "abstract", "text": [ "The etiology of trigeminal neuralgia is unknown , but both peripheral and central causes have been suggested . To investigate the role of central neurochemical mechanisms we measured epinephrine , norepinephrine and their breakdown product , vanilly mandelic acid ( VMA ) , in the cerebrospinal fluid ( CSF ) of 16 patients ( 53.3 +/- 8.3 years ) suffering from trigeminal neuralgia . As markers for the dopaminergic system , we determined CSF levels of dopamine and its metabolite homovanillic acid ( HVA ) . As a marker for the serotonergic system , we measured CSF levels of serotonin metabolite 5-hydroxyindoleacetic acid ( 5-HIAA ) . In addition , levels of the neuropeptides substance P and somatostatin were determined . The concentration of norepinephrine ( P 0.01 ) , VMA ( P 0.05 ) and HVA ( P 0.05 ) were significantly decreased in patients with trigeminal neuralgia and correlated with the duration of the disease and depression scores . 5-HIAA was also significantly decreased ( P 0.05 ) compared to control patients . Whereas substance P was significantly elevated ( P 0.05 ) , somatostatin was significantly decreased ( P 0.05 ) . Various correlations between the classical neurotransmitters and the neuropeptides could be established . We hypothesize than the sum of complex neurochemical changes plays a role in the etiology of trigeminal neuralgia , which can be separated in local and more central proceedings . The increase in substance P , a major nociceptive neuromodulator , supports the concept of a local neurogenic inflammation , possibly located in the trigeminovascular system . Depending on the duration of the disease and depression , the loss of serotonergic , dopaminergic and noradrenergic innervation seems to reflect more central changes , possibly due to alterations in their antinociceptive descending pathways ." ], "offsets": [ [ 0, 1849 ] ] } ]	[ { "id": "DerSchmerz.60100261.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "etiology" ], "offsets": [ [ 4, 12 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" }, { "db_name": "UMLS", "db_id": "C0007463" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "neuralgia" ], "offsets": [ [ 27, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027796" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "causes" ], "offsets": [ [ 82, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "trigeminal neuralgia" ], "offsets": [ [ 16, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040997" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 130, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "epinephrine" ], "offsets": [ [ 183, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014563" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "norepinephrine" ], "offsets": [ [ 197, 211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028351" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 259, 263 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "VMA" ], "offsets": [ [ 266, 269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042317" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "CSF" ], "offsets": [ [ 303, 306 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009392" }, { "db_name": "UMLS", "db_id": "C0007806" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 315, 323 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "neuralgia" ], "offsets": [ [ 373, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027796" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "mandelic acid" ], "offsets": [ [ 250, 263 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0065636" }, { "db_name": "UMLS", "db_id": "C0024685" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "cerebrospinal fluid" ], "offsets": [ [ 281, 300 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007807" }, { "db_name": "UMLS", "db_id": "C0007806" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "trigeminal neuralgia" ], "offsets": [ [ 362, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040997" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "markers" ], "offsets": [ [ 388, 395 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "CSF" ], "offsets": [ [ 440, 443 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009392" }, { "db_name": "UMLS", "db_id": "C0007806" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "dopamine" ], "offsets": [ [ 454, 462 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013030" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 495, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "homovanillic acid" ], "offsets": [ [ 482, 499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019903" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "marker" ], "offsets": [ [ 515, 521 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "CSF" ], "offsets": [ [ 564, 567 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009392" }, { "db_name": "UMLS", "db_id": "C0007806" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "serotonin" ], "offsets": [ [ 578, 587 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036751" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 621, 625 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "5-HIAA" ], "offsets": [ [ 628, 634 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020361" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "5-hydroxyindoleacetic acid" ], "offsets": [ [ 599, 625 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020361" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "neuropeptides" ], "offsets": [ [ 667, 680 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027895" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "somatostatin" ], "offsets": [ [ 697, 709 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037659" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "substance P" ], "offsets": [ [ 681, 692 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038585" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "concentration" ], "offsets": [ [ 732, 745 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "norepinephrine" ], "offsets": [ [ 749, 763 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028351" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "VMA" ], "offsets": [ [ 777, 780 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042317" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 843, 851 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "neuralgia" ], "offsets": [ [ 868, 877 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027796" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 918, 925 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "depression" ], "offsets": [ [ 930, 940 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011570" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s6-t8", "type": "umlsterm", "text": [ "trigeminal neuralgia" ], "offsets": [ [ 857, 877 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040997" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "5-HIAA" ], "offsets": [ [ 950, 956 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020361" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 1021, 1029 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "somatostatin" ], "offsets": [ [ 1092, 1104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037659" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "substance P" ], "offsets": [ [ 1040, 1051 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038585" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "neurotransmitters" ], "offsets": [ [ 1189, 1206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027908" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "neuropeptides" ], "offsets": [ [ 1215, 1228 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027895" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s10-t1", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 1321, 1325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s10-t2", "type": "umlsterm", "text": [ "etiology" ], "offsets": [ [ 1333, 1341 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" }, { "db_name": "UMLS", "db_id": "C0007463" } ] }, { "id": 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"type": "umlsterm", "text": [ "neurogenic inflammation" ], "offsets": [ [ 1530, 1553 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600467" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s12-t1", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 1640, 1647 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s12-t2", "type": "umlsterm", "text": [ "depression" ], "offsets": [ [ 1652, 1662 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011570" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s12-t3", "type": "umlsterm", "text": [ "noradrenergic" ], "offsets": [ [ 1709, 1722 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013089" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s12-t4", "type": "umlsterm", "text": [ "innervation" ], "offsets": [ [ 1723, 1734 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021516" } ] } ]	[]	[]	[ { "id": "DerSchmerz.60100261.eng.abstr-s1-r1-t2.1-t3.1", "type": 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This treatment helps to avoid the use of high-dose systemic analgesics and perhaps avoids the need for operations ." ], "offsets": [ [ 0, 563 ] ] } ]	[ { "id": "DerSchmerz.60100269.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 12, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100269.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "postoperative" ], "offsets": [ [ 25, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032790" } ] }, { "id": "DerSchmerz.60100269.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 39, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100269.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "doctors" ], "offsets": [ [ 104, 111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "DerSchmerz.60100269.eng.abstr-s1-t5", "type": "umlsterm", 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DerSchmerz.60100283.eng.abstr	DerSchmerz.60100283.eng.abstr	[ { "id": "DerSchmerz.60100283.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction . Treatment of chronic cancer pain with strong opioids is indicated in about 60-70 % of patients . Surprisingly , these very potent analgesics are prescribed with great reservations in many countries , including Germany . The aim of our investigation was to analyse the supply of opioid analgesics to outpatients with cancer pain in the region of Hannover , which has about 1.1 million inhabitants . Methods . In Germany special prescription forms , i . e . triplicate forms , have to be used for the prescription of strong opioids . At the time when our investigation took place prescriptions for outpatients had to be renewed every 7 days . For two observation periods of 6 months lasting from January to June 1988 and from January to June 1991 all of the opioid prescription forms that had been issued by general practitioners for clients of the AOK Hannover ( one of the major medical insurance companies ) were evaluated . The reasons for prescribing opioids were analysed by recording the diagnosis . The individual treatment period on an outpatient basis during these 6 months was determined , excluding , e . g . days of hospitalization . Results . During the two observation periods only 16.2 % ( 1988 ) and 19.5 % ( 1991 ) of the practitioners in the region of Hannover prescribed strong opioids to outpatients . The majority of the practitioners consisted of general practitioners and specialists in internal medicine . Although these two groups mainly function as family doctors who are responsible for the basic therapeutical needs of their patients , only 22.6-33.8 % of these doctors prescribed opioids to outpatients . In two-thirds of the patients , cancer pain was the reason for prescribing the drug . The total number of patients with a prescription for cancer pain was 164 in 1988 and 196 in 1991. Altogether 1002 prescription forms in 1988 and 1065 prescription forms in 1991 had been issued for these patients . Applied to the individual treatment period as an outpatient , only 36.0 % of the patients in 1988 and 32.1 % in 1991 received a regular prescription of strong opioids every 7 days . The mean time interval between separate prescriptions was 16.8 +/- 25.4 days in 1988 and 19.4 +/- 29.1 days in 1991. Accordingly , the majority of patients with chronic cancer pain had been supplied with opioids only occasionally . Conclusion . Our data indicate a significant undertreatment of outpatients suffering from cancer pain . Taking into account the estimated total number of patients suffering from cancer , only 14.5 % ( 1988 ) and 19.0 % ( 1991 ) of all outpatients in need of strong opioids were supplied sufficiently with those analgesics . Comparing the results from the observation period in 1988 with the results from 1991 it becomes obvious that the situation has not changed . There are different reasons for the insufficiency of opioid treatment : many physicians as well as their patients are still afraid of the side effects of strong opioids . Therefore , it is necessary to improve education concerning this issue . The legal restrictions on the use of narcotics and their complexity are another important reason for doctors not to prescribe strong opioids . In 1993 the regulations were simplified ; nevertheless , this has not led to a profound change in the attitude of the prescribing practitioners . Thus , further changes in legislation seem to be necessary so that the requirements for the prescription of strong opioids do not differ from other drugs ." ], "offsets": [ [ 0, 3515 ] ] } ]	[ { "id": "DerSchmerz.60100283.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Treatment" ], "offsets": [ [ 15, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100283.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 36, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerSchmerz.60100283.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 43, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100283.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "opioids" ], "offsets": [ [ 60, 67 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": 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DerSchmerz.60100292.eng.abstr	DerSchmerz.60100292.eng.abstr	[ { "id": "DerSchmerz.60100292.eng.abstr-passage-0", "type": "abstract", "text": [ "The prescription of strong opioide by general practitioners was studied , particularly for the treatment of chronic pain . In a medium-sized town ( around 250 000 inhabitants ) 17,839 prescriptions of strong opioids were issued by 455 doctors over 5 years ( 1 January 1990 until 31 December 1994 ) to 1,939 patients . Of these patients 37.8-48.3 % of them received only one prescription for 6 months , 60.5-75.8 % received between 1 and 4 prescriptions for 6 months , and only 20.9-35.7 % of all patients received 5 or more prescriptions for 6 months . The amount of strong opioids prescribed for cancer pain relief seems to be almost the same in 1992 as 10 years ago . The consumption of oral morphine has steadily increased compared to 1982 and constitutes almost one-half of all narcotics prescribed for pain treatment by general practitioners . For pain treatment the value of strong opioids is recognized by both patients and physicians in contrast to the prescription of levomethadone as substitution therapy for drug-addicted patients . The 6.7 % of the physicians who participated in methadone substitution therapy prescribed more strong opioids ( 52.4 % of prescriptions ) than all other physicians together prescribe for pain treatment . In order to safeguard the quality of medical care for pain treatment by strong opioid analgesics , unbiased training of physicians and a clear definition of narcotics is required . It is suggested that the expression \" narcotic prescription \" be changed related to the legislative terminology in the pharmacology-related expression \" analgesic prescription \" . The prescribing regulations should not constrain medical treatment , but create a basic rule for the prescription of strong opioids ." ], "offsets": [ [ 0, 1742 ] ] } ]	[ { "id": "DerSchmerz.60100292.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "prescription" ], "offsets": [ [ 4, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033080" } ] }, { "id": "DerSchmerz.60100292.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 95, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100292.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 116, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100292.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "prescription of" ], "offsets": [ [ 4, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033080" } ] }, { "id": "DerSchmerz.60100292.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "general practitioners" ], "offsets": [ [ 38, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017319" } ] }, { "id": "DerSchmerz.60100292.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "prescriptions" ], "offsets": [ [ 184, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033080" } ] }, { "id": "DerSchmerz.60100292.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "opioids" ], "offsets": [ [ 208, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.60100292.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "doctors" ], "offsets": [ [ 235, 242 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "DerSchmerz.60100292.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 307, 315 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100292.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "prescriptions of" ], "offsets": [ [ 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It is important that the use of the narcotic be justified in the sense of § 13 Abs. 1 of the drug control regulation , as judged by the responsible prescriber of the drug , and that any offence be punished . The use of triplicate prescriptions guarantees sufficient proof . Legislation is requested that will substitute for the present drug control regulations , which are difficult to handle ." ], "offsets": [ [ 0, 1152 ] ] } ]	[ { "id": "DerSchmerz.60100299.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "prescription" ], "offsets": [ [ 39, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033080" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "drugs" ], "offsets": [ [ 66, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 106, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 126, 130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s1-t5", "type": "umlsterm", 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DerSchmerz.60100302.eng.abstr	DerSchmerz.60100302.eng.abstr	[ { "id": "DerSchmerz.60100302.eng.abstr-passage-0", "type": "abstract", "text": [ "Rules still valid today continue the tradition of state narcotics control , conceding therapeutic decisions to the physician , but at the same time allowing only restrictive use of narcotics . Legal control of medically indicated use of narcotics is burdened with conflicts . Recently , physicians have been given more scope in the use of strong opioids for pain therapy . Existing limits for a dose of opioids may be exceeded when necessary . 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DerSchmerz.60100312.eng.abstr	DerSchmerz.60100312.eng.abstr	[ { "id": "DerSchmerz.60100312.eng.abstr-passage-0", "type": "abstract", "text": [ "In spite of the fact that the treatment of pain is highly developed , outpatient care of patients suffering from chronic pain is frequently insufficient . In particular general practitioners often refrain from prescribing the necessary pain therapy with opioids . Because of the contract regarding medical treatment , however , the patient has a legal claim to adequate pain treatment , if necessary by administration of opioids . The failure to meet this claim may not only give rise to a claim for damages towards the doctor , but even to a charge of bodily injury . In comparison , charging the physician with criminal behavior on the basis of the Narcotics Act is rather unlikely . Negligent or incorrect prescription of narcotic drugs does not constitute criminal behavior , but an administrative offence . Even this is hardly something which the physician has to fear . Any medically necessary administration of opioids is covered by the Narcotics Prescription Ordinance . The narcotics prescription form , however , remains indispensable for the safety in the use of narcotics . The doctor's prescription alone is obviously not sufficient to curb the considerable abuse of pharmaceutical products among the population . In the course of the introduction of EDP-readable narcotics prescription form as of 1 July 1995 , however , the issuing of this kind of prescription was further simplified . Handwritten particulars will soon be entirely a thing of the past . Now that the legal and administrative conditions for prescribing opioids have been consolidated , the main objective is to exhaust the possibilities of prescription for the benefit of patients suffering from pain in a better way . This is first and foremost , an organizational and technical task of the medical professional group . In particular , training and continuing education in the field of pain therapy must be further developed without delay ." ], "offsets": [ [ 0, 1922 ] ] } ]	[ { "id": "DerSchmerz.60100312.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 30, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100312.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 43, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100312.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "outpatient" ], "offsets": [ [ 70, 80 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029921" } ] }, { "id": "DerSchmerz.60100312.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "care" ], "offsets": [ [ 81, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0150499" } ] }, { "id": "DerSchmerz.60100312.eng.abstr-s1-t5", "type": "umlsterm", "text": 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DerSchmerz.70110079.eng.abstr	DerSchmerz.70110079.eng.abstr	[ { "id": "DerSchmerz.70110079.eng.abstr-passage-0", "type": "abstract", "text": [ "Craniomandibular disorders are suggested to be responsible for many cases of chronic pain of the head and face . The assessment of dysfunctional factors in diseases of chronic head and facial pain normally requires special knowledge and equipment for the diagnosis and therapy of stomatognathic dysfunction . However , the first signs can be evaluated rather well without using complete equipment , which is not always avaible in general practice . It is therefore important that general practitioners have a simple , time-efficient method of routine screening based on sufficient methods and tests . Thus , we would like to present a questionnaire consisting of ten points that cover the valid elements of complete stomatognathic assessment . Answering these questions reveals signs of dysfunctional components of craniomandibular disorders , which indicate a dysfunction diagnosis and even better , consultation with a specialist ." ], "offsets": [ [ 0, 933 ] ] } ]	[ { "id": "DerSchmerz.70110079.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 17, 26 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 85, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "head" ], "offsets": [ [ 97, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "face" ], "offsets": [ [ 106, 110 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015450" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "Craniomandibular disorders" ], "offsets": [ [ 0, 26 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079173" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 117, 127 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 156, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "head" ], "offsets": [ [ 176, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 192, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "knowledge" ], "offsets": [ [ 223, 232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376554" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "equipment" ], "offsets": [ [ 237, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220824" }, { "db_name": "UMLS", "db_id": "C0014672" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 255, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 269, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "dysfunction" ], "offsets": [ [ 295, 306 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031847" } ] }, { "id": "DerSchmerz.70110079.eng.abstr-s2-t10", "type": 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DerSchmerz.70110085.eng.abstr	DerSchmerz.70110085.eng.abstr	[ { "id": "DerSchmerz.70110085.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : The present study examines the correlations between pain intensity , mood and pain-alleviating actions in pre-chronic low back pain patients . The three variables were obtained with the Ulm Pain Diary ( Ulmer Schmerztagebuch , UST ) . Methods : Thirty-eight patients with low back pain described pain intensity , effect of pain on mood and medication as well as other therapies over a 3-week period ( 21 days ) . The patients had a history of pain for between 6 weeks and 6 months . Clinical and orthopedic examinations revealed no relevant organic findings explaining the pain process . Results : Pain occurred on 18.1 ( of 21 ) days . Half of the patients ( n=19) used medication or took other actions against their pain . Correlations between the three variables demonstrated that all three were significantly related . Partial correlations showed in addition to a high correlation between pain intensity and mood , that the frequency of pain-relieving actions was far less related to pain intensity than to mood . The group that took actions against their pain had a higher level of pain intensity than the no-action group . Furthermore , the effect of pain on mood was significantly greater in this group than in the no-action group . Conclusion : The findings indicate that pain intensity , mood and actions against pain are highly correlated . When pain intensity is statistically controlled , the influence of mood on taking medication or other actions against pain becomes more pronounced . It can be concluded that self-initiated actions against pain depend much more on mood than on pain intensity in pre-chronic low back pain patients ." ], "offsets": [ [ 0, 1663 ] ] } ]	[ { "id": "DerSchmerz.70110085.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 67, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110085.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "mood" ], "offsets": [ [ 84, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026516" } ] }, { "id": "DerSchmerz.70110085.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 142, 146 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110085.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 147, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110085.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "back pain" ], "offsets": [ [ 137, 146 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004604" } ] }, { "id": "DerSchmerz.70110085.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "low back pain" ], "offsets": [ [ 133, 146 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024031" } ] }, { "id": "DerSchmerz.70110085.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Pain" ], "offsets": [ [ 205, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110085.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "Diary" ], "offsets": [ [ 210, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376660" } ] }, { "id": "DerSchmerz.70110085.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Methods" ], "offsets": [ [ 250, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110085.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 273, 281 ] ], 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The influence of music therapy could be even better demonstrated in the systematic analysis of the single cases by individual profiles . Active music therapy affects especially the communicative and emotional dimension of chronic pain . Psychophysiological and psychodynamic models are presented to explain the effectiveness of music therapy on pain reduction . Clinical studies on music therapy as well as on other \" art therapies \" should relate the analysis of clinical parameters to the descriptive-phenomenological documentation of the therapeutic process to demonstrate systematically the influence of music and art in the individual case ." ], "offsets": [ [ 0, 1375 ] ] } ]	[ { "id": "DerSchmerz.70110091.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "publications" ], "offsets": [ [ 19, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034036" } ] }, { "id": "DerSchmerz.70110091.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "music" ], "offsets": [ [ 52, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026867" } ] }, { "id": "DerSchmerz.70110091.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 58, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110091.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain" ], 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DerSchmerz.70110101.eng.abstr	DerSchmerz.70110101.eng.abstr	[ { "id": "DerSchmerz.70110101.eng.abstr-passage-0", "type": "abstract", "text": [ "In Middle Franconia , one of the larger Bavarian administrative division ( population 1994 : 1,657 , 101 ) , the number of patients suffering from cancer pain , chronic headache and chronic back pain is not known . Furthermore , there are no data on interdisciplinary organization of outpatient pain management ." ], "offsets": [ [ 0, 312 ] ] } ]	[ { "id": "DerSchmerz.70110101.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "population" ], "offsets": [ [ 75, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032659" } ] }, { "id": "DerSchmerz.70110101.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 123, 131 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110101.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 147, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006826" } ] }, { "id": "DerSchmerz.70110101.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 154, 158 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110101.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "headache" ], "offsets": [ [ 169, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.70110101.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "back" ], "offsets": [ [ 190, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004600" } ] }, { "id": "DerSchmerz.70110101.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 195, 199 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110101.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "chronic headache" ], "offsets": [ [ 161, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0151293" } ] }, { "id": "DerSchmerz.70110101.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "back pain" ], "offsets": [ [ 190, 199 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004604" } ] }, { "id": "DerSchmerz.70110101.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "organization" ], "offsets": [ [ 268, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220885" }, { "db_name": "UMLS", "db_id": 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DerSchmerz.70110108.eng.abstr	DerSchmerz.70110108.eng.abstr	[ { "id": "DerSchmerz.70110108.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Extracorporeal shock waves ( ESW ) are being used increasingly frequently for the treatment of narrowly localized pain in the musculoskeletal system . Pain is normally associated with muscular dysfunction . Beginning with the observation that not only is the pain soothed by treatment with ESW , but that the muscular dysfunction itself is relieved , an attempt has been made to treat the impaired function in cases of infantile cerebral palsy with ESW . Method : In 35 children and young people with mainly spastic disturbances of movement , the bellies of those muscles producing the flexion contracture of the lower limb were each treated with 500 non-focused pulses of low-energy ESW . The focus ( focal pressure 10 MPA=0.06 mJ/mm ) of the shock waves itself was placed either within the coupling cushion of the therapy source ( Minilith , Storz Medical , CH-Kreuzlingen ) or obliquely outside the patient's body . In this way ESW could be dispersed throughout the muscles and the risk of undesirable effects was minimized . The energy used amounted to about 30% of the threshold value at which cellular damage from focused treatment with ESW had been observed in the endothelium of the human umbilical cord . Results : The degree of movement at the hip joint increased after one treatment by an average of 17 ° , at the knee joint by 12.3 ° and at the ankle joint by 7.1 ° , each increase being statistically significant . Muscular stiffness , spastic co-contractions , and myofascial viscoelasticity , as well as dyskinetic and ataxic symptoms , decreased . It appeared as if a systemic action had entered into the motor control . Together with an increase in general proprioception , there was an improvement in body image , in economy of movement and also in the limbs that had not been treated . A few patients showed euphoric reactions for about 2 days after treatment . No undesirable effects were observed during a follow-up of 12 months . The treatment was painless and is therefore suitable for children . The biomechanical improvement remained for several weeks and this time could be used for initiating an improved pattern of movement . Conclusion : ESW is suitable for use as an additional instrument for physiotherapeutic treatment of infantile cerebral palsy . The effective action of ESW on disturbed peripheral muscles has been discussed in terms of positive pressure and tensile wave forces and/or forces acting by cavitation . The results obtained in this pilot investigation showed particular a decrease in muscle stiffness . A controlled investigation with gait analysis and psychological control is to be undertaken ." ], "offsets": [ [ 0, 2659 ] ] } ]	[ { "id": "DerSchmerz.70110108.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 97, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 129, 133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "musculoskeletal system" ], "offsets": [ [ 141, 163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026860" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Pain" ], "offsets": [ [ 166, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "dysfunction" ], "offsets": [ [ 208, 219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031847" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "observation" ], "offsets": [ [ 241, 252 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302523" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 274, 278 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 290, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "dysfunction" ], "offsets": [ [ 333, 344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031847" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "function" ], "offsets": [ [ 413, 421 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031843" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "palsy" ], "offsets": [ [ 453, 458 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030440" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "cerebral palsy" ], "offsets": [ [ 444, 458 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007789" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "infantile cerebral palsy" ], "offsets": [ [ 434, 458 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007789" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Method" ], "offsets": [ [ 470, 476 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "children" ], "offsets": [ [ 485, 493 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008059" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "people" ], "offsets": [ [ 504, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027361" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "spastic" ], "offsets": [ [ 523, 530 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026838" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "movement" ], "offsets": [ [ 547, 555 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026649" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "muscles" ], "offsets": [ [ 579, 586 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "contracture" ], "offsets": [ [ 609, 620 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009917" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "limb" ], "offsets": [ [ 634, 638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "pulses" ], "offsets": [ [ 678, 684 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034107" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "lower limb" ], "offsets": [ [ 628, 638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 723, 731 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "shock" ], "offsets": [ [ 759, 764 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036974" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 831, 838 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "muscles" ], "offsets": [ [ 984, 991 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 1000, 1004 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "risk of" ], "offsets": [ [ 1000, 1007 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "undesirable effects" ], "offsets": [ [ 1008, 1027 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001688" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "value" ], "offsets": [ [ 1099, 1104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1143, 1152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "endothelium" ], "offsets": [ [ 1187, 1198 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014257" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "human" ], "offsets": [ [ 1206, 1211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "umbilical cord" ], "offsets": [ [ 1212, 1226 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041633" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "movement" ], "offsets": [ [ 1253, 1261 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026649" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "hip" ], "offsets": [ [ 1269, 1272 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019552" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "joint" ], "offsets": [ [ 1273, 1278 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1299, 1308 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "knee" ], "offsets": [ [ 1340, 1344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022742" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t6", "type": "umlsterm", "text": [ "joint" ], "offsets": [ [ 1345, 1350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t7", "type": "umlsterm", "text": [ "ankle" ], "offsets": [ [ 1372, 1377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003086" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t8", "type": "umlsterm", "text": [ "joint" ], "offsets": [ [ 1378, 1383 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t9", "type": "umlsterm", "text": [ "hip joint" ], "offsets": [ [ 1269, 1278 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019558" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t10", "type": "umlsterm", "text": [ "knee joint" ], "offsets": [ [ 1340, 1350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022745" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s8-t11", "type": "umlsterm", "text": [ "ankle joint" ], "offsets": [ [ 1372, 1383 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003087" } ] }, { "id": "DerSchmerz.70110108.eng.abstr-s9-t1", "type": 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DerSchmerz.70110113.eng.abstr	DerSchmerz.70110113.eng.abstr	[ { "id": "DerSchmerz.70110113.eng.abstr-passage-0", "type": "abstract", "text": [ "The authors demonstrate a way to treat meralgia paresthetica ( \" jeans disease \" ) with acupuncture . Two patients with therapy-resistant chronic pain and paresthesia of the lateral thigh became free of symptoms quickly and remained under acupuncture therapy . Gynecological , vertebral and urological factors must be excluded before any kind of symptomatic therapy is begun . The advantages and disadvantages of acupuncture are discussed ." ], "offsets": [ [ 0, 440 ] ] } ]	[ { "id": "DerSchmerz.70110113.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 71, 78 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 88, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 106, 114 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "therapy-resistant" ], "offsets": [ [ 120, 137 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 146, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "paresthesia" ], "offsets": [ [ 155, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030554" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "thigh" ], "offsets": [ [ 182, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039866" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 203, 211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 239, 250 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 251, 258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "acupuncture therapy" ], "offsets": [ [ 239, 258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001303" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 358, 365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110113.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 413, 424 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] } ]	[]	[]	[ { "id": "DerSchmerz.70110113.eng.abstr-s1-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110113.eng.abstr-s2-t2", "arg2_id": "DerSchmerz.70110113.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerSchmerz.70110113.eng.abstr-s1-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110113.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.70110113.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-r1-t1.1-t6.1", "type": "performs", "arg1_id": "DerSchmerz.70110113.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.70110113.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-r2-t5.1-t8.1", "type": "location_of", "arg1_id": "DerSchmerz.70110113.eng.abstr-s2-t5", "arg2_id": "DerSchmerz.70110113.eng.abstr-s2-t8", "normalized": [] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-r3-t1.1-t2.1", "type": "performs", "arg1_id": "DerSchmerz.70110113.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.70110113.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-r4-t5.1-t6.1", "type": "location_of", "arg1_id": "DerSchmerz.70110113.eng.abstr-s2-t5", "arg2_id": "DerSchmerz.70110113.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-r5-t5.1-t2.1", "type": "location_of", "arg1_id": "DerSchmerz.70110113.eng.abstr-s2-t5", "arg2_id": "DerSchmerz.70110113.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.70110113.eng.abstr-s2-r6-t1.1-t8.1", "type": "performs", "arg1_id": "DerSchmerz.70110113.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.70110113.eng.abstr-s2-t8", "normalized": [] } ]
DerSchmerz.70110116.eng.abstr	DerSchmerz.70110116.eng.abstr	[ { "id": "DerSchmerz.70110116.eng.abstr-passage-0", "type": "abstract", "text": [ "A rheumatologist and a medical psychotherapist collaborate in offering periodically a cognitive behavioral treatment program for pain control for the patients of a rheumatological practice . The program consists of a biopsychosocial model of chronic pain , individualized relaxation training combining progressive muscle relaxation and some elements of autogenous training and meditation , several attention-related techniques and cognitive restructuring . From 1993 to 1995 , 50 patients took part in five training courses . The compliance of the patients was satisfactory and the drop-out rate low ( 8% ) . In a post hoc interview 4 weeks later and another 2 years after the end of the training most of the patients assessed the program as useful for reduction of pain , increase of activity and enhancement of mood . Psychotherapeutic experience in group therapy or special training for non-psychotherapeutic physicians with continuous supervision is necessary in order to conduct a qualified treatment program . Within medical primary care , rheumatologists can motivate their patients towards active pain management , which can help to prepare patients for further psychotherapy in cases with psychiatric disorders and/or severe psychosocial strains ." ], "offsets": [ [ 0, 1256 ] ] } ]	[ { "id": "DerSchmerz.70110116.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "rheumatologist" ], "offsets": [ [ 2, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035431" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 107, 116 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "program" ], "offsets": [ [ 117, 124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376691" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 129, 133 ] ], 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DerSchmerz.70110148.eng.abstr	DerSchmerz.70110148.eng.abstr	[ { "id": "DerSchmerz.70110148.eng.abstr-passage-0", "type": "abstract", "text": [ "Recurrent abdominal pain ( RAP ) is one of the most common pain syndromes in childhood , with prevalence rates ranging from 10 to 20% in all school-age children . In nearly 50% the complaints persist over many years of their life-span to adolescence or adulthood . Although the empirical findings have increased in the last decade , our knowledge about the etiology , pathogenesis , and pathophysiology is still very limited . Current approaches suggest that we understand recurrent pain syndromes as a complex and multidimensional disturbance ( biopsychosocial paradigm ) . In this respect there is strong evidence for the major importance of psychosocial causes ( daily hassles , specific life events ) , psychopathological factors ( anxiety , depression , somatization disorder ) , and social environmental influences ( mother's psychopathology , social modelling , reinforcement ) in the pathogenesis of functional abdominal pain . The noticeable correlation with other pain syndromes and functional disturbances indicates that recurrent pain may possibly be a manifestation of a basic somatization disorder . The unfavourable long-term prognosis supports the need for early and specific interventions . Psychological treatment requires a medical examination to exclude organic origins . Some of these invasive diagnostic procedures can be very difficult , expensive and distressing for the child . Behavioural medicine is based upon having an extensive family history and symptom analysis . The psychological interventions applied in clinical practice include prophylaxis , reduction of pain symptoms and environmental modification . In recent years there has been an increasing trend to create more complex and multidimensional behavioural treatment programs for children . Although preliminary data on the use of these behavioural medicine programs have shown some promise , further investigations are needed to examine the applicability and effectiveness of specific interventions in the treatment of abdominal pain symptoms ." ], "offsets": [ [ 0, 2034 ] ] } ]	[ { "id": "DerSchmerz.70110148.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 20, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110148.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 59, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110148.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 64, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerSchmerz.70110148.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "prevalence" ], "offsets": [ [ 94, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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"id": "DerSchmerz.70110148.eng.abstr-s13-r19-t1.1-t6.1", "type": "issue_in", "arg1_id": "DerSchmerz.70110148.eng.abstr-s13-t1", "arg2_id": "DerSchmerz.70110148.eng.abstr-s13-t6", "normalized": [] }, { "id": "DerSchmerz.70110148.eng.abstr-s13-r20-t3.1-t6.1", "type": "method_of", "arg1_id": "DerSchmerz.70110148.eng.abstr-s13-t3", "arg2_id": "DerSchmerz.70110148.eng.abstr-s13-t6", "normalized": [] }, { "id": "DerSchmerz.70110148.eng.abstr-s13-r21-t3.1-t6.1", "type": "issue_in", "arg1_id": "DerSchmerz.70110148.eng.abstr-s13-t3", "arg2_id": "DerSchmerz.70110148.eng.abstr-s13-t6", "normalized": [] }, { "id": "DerSchmerz.70110148.eng.abstr-s13-r22-t3.1-t1.1", "type": "method_of", "arg1_id": "DerSchmerz.70110148.eng.abstr-s13-t3", "arg2_id": "DerSchmerz.70110148.eng.abstr-s13-t1", "normalized": [] }, { "id": "DerSchmerz.70110148.eng.abstr-s13-r23-t3.1-t6.1", "type": "treats", "arg1_id": "DerSchmerz.70110148.eng.abstr-s13-t3", "arg2_id": "DerSchmerz.70110148.eng.abstr-s13-t6", "normalized": [] } ]
DerSchmerz.70110165.eng.abstr	DerSchmerz.70110165.eng.abstr	[ { "id": "DerSchmerz.70110165.eng.abstr-passage-0", "type": "abstract", "text": [ "Methods : Long-term outcome in terms of well-being , depression and ability to cope was evaluated by means of a mailed questionnaire up to 5 years after participation in an integrated group treatment program for chronic musculoskeletal pain ( mostly back pain ) . Sixty-one completed questionnaires were available for analysis , representing 69% of all 89 participants ." ], "offsets": [ [ 0, 370 ] ] } ]	[ { "id": "DerSchmerz.70110165.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Methods" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "depression" ], "offsets": [ [ 53, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011570" } ] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "ability" ], "offsets": [ [ 68, 75 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085732" } ] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "questionnaire" ], "offsets": [ [ 119, 132 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034394" } ] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 190, 199 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "program" ], "offsets": [ [ 200, 207 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376691" } ] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 236, 240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 255, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "back pain" ], "offsets": [ [ 250, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004604" } ] }, { "id": "DerSchmerz.70110165.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "questionnaires" ], "offsets": [ [ 284, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034394" } ] }, { "id": "DerSchmerz.70110165.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "analysis" ], "offsets": [ [ 318, 326 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] } ]	[]	[]	[ { "id": "DerSchmerz.70110165.eng.abstr-s1-r1-t5.1-t9.1", "type": "treats", "arg1_id": "DerSchmerz.70110165.eng.abstr-s1-t5", "arg2_id": "DerSchmerz.70110165.eng.abstr-s1-t9", "normalized": [] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-r2-t1.2-t5.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110165.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.70110165.eng.abstr-s1-t5", "normalized": [] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-r3-t9.1-t1.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.70110165.eng.abstr-s1-t9", "arg2_id": "DerSchmerz.70110165.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.70110165.eng.abstr-s1-r4-t1.2-t3.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110165.eng.abstr-s1-t1", 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DerSchmerz.70110172.eng.abstr	DerSchmerz.70110172.eng.abstr	[ { "id": "DerSchmerz.70110172.eng.abstr-passage-0", "type": "abstract", "text": [ "In a prospective study 30 patients suffering from a lumbar disc-prolaps and typical neurological symptoms were examined with regard to the predictors of the outcome 15 months postoperatively . Alongside the clinical examination and the raising of illness-anamnesis the Giessen pain questionaire ( Giessener Beschwerde-Bogen ) , the Giessen-Test , the Freiburg Personality Inventory ( Freiburger Persoenlichkeits-Inventar ) , the Mainz pain questionaire und a pain scale were used ." ], "offsets": [ [ 0, 481 ] ] } ]	[ { "id": "DerSchmerz.70110172.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 26, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 97, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "prospective study" ], "offsets": [ [ 5, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033522" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "illness-anamnesis" ], "offsets": [ [ 247, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021055" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 277, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "Personality" ], "offsets": [ [ 360, 371 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031208" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "Inventory" ], "offsets": [ [ 372, 381 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031213" }, { "db_name": "UMLS", "db_id": "C0021941" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 435, 439 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 459, 463 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "scale" ], "offsets": [ [ 464, 469 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0175659" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "clinical examination" ], "offsets": [ [ 207, 227 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031809" } ] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "Personality Inventory" ], "offsets": [ [ 360, 381 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031213" } ] } ]	[]	[]	[ { "id": "DerSchmerz.70110172.eng.abstr-s1-r1-t1.1-t2.1", "type": "performs", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r1-t6.1-t3.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t6", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r2-t4.1-t7.1", "type": "conceptual_part_of", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r3-t2.1-t1.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t2", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r4-t1.1-t3.1", "type": "result_of", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r5-t4.2-t3.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r6-t7.1-t3.1", "type": "measures", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t7", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r7-t7.1-t4.2", "type": "uses", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t7", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r8-t7.1-t1.1", "type": "measures", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t7", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r9-t6.1-t1.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t6", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r10-t9.1-t7.1", "type": "conceptual_part_of", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t9", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r11-t2.1-t3.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t2", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r12-t4.2-t1.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.70110172.eng.abstr-s2-r13-t3.1-t1.1", "type": "result_of", "arg1_id": "DerSchmerz.70110172.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.70110172.eng.abstr-s2-t1", "normalized": [] } ]
DerSchmerz.70110180.eng.abstr	DerSchmerz.70110180.eng.abstr	[ { "id": "DerSchmerz.70110180.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Because of their frequency and consequences sciatica remains a demanding clinical entity with significant social and economical impact . There is a high demand on therapeutic modalities , using folk medicine methods in the treatment of orthopaedic diseases . No data is available on the usefullness of methods like natural herbs in combination with acupuncture . Aim of our study was to present data on the effect of acupuncture and cytokineinhibiting natural herbs in sciatic pain . We compared these results with nerve root infiltration by local anaesthetics and corticosteroids in our orthopaedic outpatient clinic . Materials and Results : 278 patients with chronic pain for at least 3 months were observed . All three therapeutical modalities showed improvement of pain scores . Best results were gained with steroid injection ( n=26; 66% pain reduction ) , acupuncture in combination with herbs improved the pain in average of 62% ( n=230), whereas injection with local anaesthetic had a pain reduction of 48% ( n=22). Sole Mepivacain-HCl treatment had significant less pain reduction compared to the other treatment modalities . Conclusion : According to our results acupuncture in combination with herbs and steroid nerve blocks appear to be an effective and thus recommendable conservative therapy in cases of sciatic pain . Taking into account that patients increasingly prefer ethnomedical modalities of treatment our study gains importance for practising orthopaedists ." ], "offsets": [ [ 0, 1497 ] ] } ]	[ { "id": "DerSchmerz.70110180.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "frequency" ], "offsets": [ [ 32, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376249" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "sciatica" ], "offsets": [ [ 59, 67 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036396" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 178, 189 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "medicine" ], "offsets": [ [ 214, 222 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025118" }, { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 223, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 238, 247 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 263, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "folk medicine" ], "offsets": [ [ 209, 222 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016419" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 317, 324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "herbs" ], "offsets": [ [ 338, 343 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019240" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 364, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 432, 443 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "cytokineinhibiting" ], "offsets": [ [ 448, 466 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079189" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "herbs" ], "offsets": [ [ 475, 480 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019240" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 492, 496 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 530, 535 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "anaesthetics" ], "offsets": [ [ 563, 575 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002932" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "corticosteroids" ], "offsets": [ [ 580, 595 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001617" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "outpatient" ], "offsets": [ [ 615, 625 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029921" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "local anaesthetics" ], "offsets": [ [ 557, 575 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002934" }, { "db_name": "UMLS", "db_id": "C0002921" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "outpatient clinic" ], "offsets": [ [ 615, 632 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002424" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 663, 671 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 685, 689 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 785, 789 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "steroid" ], "offsets": [ [ 829, 836 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "injection" ], "offsets": [ [ 837, 846 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021485" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 859, 863 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 878, 889 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "herbs" ], "offsets": [ [ 910, 915 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019240" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t6", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 929, 933 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t7", "type": "umlsterm", "text": [ "injection" ], "offsets": [ [ 970, 979 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021485" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t8", "type": "umlsterm", "text": [ "anaesthetic" ], "offsets": [ [ 991, 1002 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002932" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t9", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1009, 1013 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t10", "type": "umlsterm", "text": [ "Sole" ], "offsets": [ [ 1040, 1044 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037613" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t11", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1060, 1069 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t12", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1091, 1095 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t13", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1128, 1137 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s8-t14", "type": "umlsterm", "text": [ "local anaesthetic" ], "offsets": [ [ 985, 1002 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002934" }, { "db_name": "UMLS", "db_id": "C0002921" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 1189, 1200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "herbs" ], "offsets": [ [ 1221, 1226 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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DerSchmerz.70110185.eng.abstr	DerSchmerz.70110185.eng.abstr	[ { "id": "DerSchmerz.70110185.eng.abstr-passage-0", "type": "abstract", "text": [ "Continuous epidural infusion of bupivacaine with the opioid fentanyl represents an effective analgesic method in the therapy of strong postoperative pain after major surgery . Preparation of the required infusion solution in syringes with a volume of 50 ml immediately prior to administration is routinely performed by nursing staff in Germany . The effort required for the preparation is associated with logistical and pharmaceutical difficulties . The preparation of a mixture of bupivacaine hydrochloride 0.06% and fentanyl 0.0002% in 250 ml infusion bags at the pharmacy of the University Hospital Mainz is described . To determine the physicochemical stability , the concentration of bupivacaine-HCl and fentanyl was assessed using HPLC over a period of 32 days ; in addition the pH values were determined . After 32 days 95% of the bupivacaine hydrochloride and fentanyl baseline values were recorded . The pH baseline value had decreased from 5.48-5.52 to 0.5-0.7 units . The measured values confirm the physicochemical stability of the mixture of bupivacaine hydrochloride 0.06% and fentanyl 0.0002% over a period of 32 days . The infusion bag can be stored for 4 weeks at room temperature ." ], "offsets": [ [ 0, 1199 ] ] } ]	[ { "id": "DerSchmerz.70110185.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "bupivacaine" ], "offsets": [ [ 32, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006400" } ] }, { "id": "DerSchmerz.70110185.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "opioid" ], "offsets": [ [ 53, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.70110185.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "fentanyl" ], "offsets": [ [ 60, 68 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015846" } ] }, { "id": "DerSchmerz.70110185.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "analgesic" ], "offsets": [ [ 93, 102 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.70110185.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "method" ], "offsets": [ [ 103, 109 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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DerSchmerz.70110213.eng.abstr	DerSchmerz.70110213.eng.abstr	[ { "id": "DerSchmerz.70110213.eng.abstr-passage-0", "type": "abstract", "text": [ "Both preclinical and clinical evidence support the usefulness of antidepressants in chronic pain treatment . Monoamine uptake inhibitors influence the neurotransmissions of noradrenaline ( NA ) and/or serotonin ( 5-HT ) ; their effect on nociception is thought to take place predominantly within the spinal cord . Antidepressant drugs seem to differ in their properties as analgesics and as thymoleptics . The present work is aimed at correlating the special mechanism of action of antidepressants in diminishing nocicepetion with the pharmacological profile of these drugs in clinical pain treatment . From a preclinical , experimental point of view , it can be expected , that mixed type uptake blockers should be superior to selective NA or 5-HT uptake inhibitors . The analgesic profile of antidepressants was established by a metaanalysis of clinical trials on the effect of these drugs , given alone or in combination with other analgetics , in chronic pain syndromes . 57 Clinical trials were separated into 5 groups according to their scientific quality : [ 1 ] placebo-controlled double-blind studies with high power ; [ 2 ] placebo-controlled double-blind studies with low power ; [ 3-4 ] open controlled studies or studies with historical controls ; [ 5 ] case reports . A study was positive if the tested antidepressant was more effective than placebo or the compared drug or seemed beneficial with respect to the interval of its previous absence . The most effective antidepressants in chronic pain treatment only included unselective monoamine reuptake inhibitors in the following rank order : amitriptyline > clomipramine > = desipramine > = imipramine > = doxepin . A statement about the appropriate dosage of these drugs in chronic pain treatment , however , must wait for properly conducted dose finding studies which include the measurement of plasma concentrations ." ], "offsets": [ [ 0, 1886 ] ] } ]	[ { "id": "DerSchmerz.70110213.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "antidepressants" ], "offsets": [ [ 65, 80 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003289" } ] }, { "id": "DerSchmerz.70110213.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 92, 96 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110213.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 97, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110213.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "inhibitors" ], "offsets": [ [ 126, 136 ] ], "normalized": [ { "db_name": "UMLS", 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DerSchmerz.70110241.eng.abstr	DerSchmerz.70110241.eng.abstr	[ { "id": "DerSchmerz.70110241.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : Postoperative nausea and vomiting remains an important problem . Many risk factors have been identified ; however , the importance of postoperative analgesic technique and patient expectation remain poorly defined ." ], "offsets": [ [ 0, 225 ] ] } ]	[ { "id": "DerSchmerz.70110241.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Postoperative" ], "offsets": [ [ 10, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032790" } ] }, { "id": "DerSchmerz.70110241.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "nausea" ], "offsets": [ [ 24, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027497" } ] }, { "id": "DerSchmerz.70110241.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "vomiting" ], "offsets": [ [ 35, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042963" } ] }, { "id": "DerSchmerz.70110241.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Postoperative nausea" ], "offsets": [ [ 10, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0520904" } ] }, { "id": "DerSchmerz.70110241.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 80, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerSchmerz.70110241.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "postoperative" ], "offsets": [ [ 144, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032790" } ] }, { "id": "DerSchmerz.70110241.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "analgesic" ], "offsets": [ [ 158, 167 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.70110241.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "technique" ], "offsets": [ [ 168, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110241.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 182, 189 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110241.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "risk factors" ], "offsets": [ [ 80, 92 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035648" } ] } ]	[]	[]	[ { "id": "DerSchmerz.70110241.eng.abstr-s1-r1-t4.1-t2.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110241.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.70110241.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.70110241.eng.abstr-s1-r2-t3.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110241.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.70110241.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerSchmerz.70110241.eng.abstr-s1-r3-t4.1-t3.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110241.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.70110241.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.70110241.eng.abstr-s1-r4-t2.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110241.eng.abstr-s2-t2", "arg2_id": "DerSchmerz.70110241.eng.abstr-s2-t4", "normalized": [] } ]
DerSchmerz.70110254.eng.abstr	DerSchmerz.70110254.eng.abstr	[ { "id": "DerSchmerz.70110254.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : Two methods for the assessment of change are evaluated : ( 1 ) subjects ' ratings of the outcome taken after termination of the treatment , and ( 2 ) comparison of test scores taken before the beginning and after termination of the treatment ." ], "offsets": [ [ 0, 253 ] ] } ]	[ { "id": "DerSchmerz.70110254.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 14, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 30, 40 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 138, 147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "test" ], "offsets": [ [ 174, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0076174" } ] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 242, 251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]	[]	[]	[ { "id": "DerSchmerz.70110254.eng.abstr-s1-r3-t1.2-t5.1", "type": "precedes", "arg1_id": "DerSchmerz.70110254.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.70110254.eng.abstr-s1-t5", "normalized": [] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-r4-t5.1-t4.1", "type": "uses", "arg1_id": "DerSchmerz.70110254.eng.abstr-s1-t5", "arg2_id": "DerSchmerz.70110254.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-r5-t3.1-t4.1", "type": "uses", "arg1_id": "DerSchmerz.70110254.eng.abstr-s1-t3", "arg2_id": "DerSchmerz.70110254.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-r6-t1.2-t3.1", "type": "precedes", "arg1_id": "DerSchmerz.70110254.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.70110254.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-r7-t1.2-t4.1", "type": "analyzes", "arg1_id": "DerSchmerz.70110254.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.70110254.eng.abstr-s1-t4", "normalized": [] } ]
DerSchmerz.70110263.eng.abstr	DerSchmerz.70110263.eng.abstr	[ { "id": "DerSchmerz.70110263.eng.abstr-passage-0", "type": "abstract", "text": [ "Despite excellent technical means of imaging the posterior fossa by magnetic resonance imaging ( MRI ) , some infratentorial space-occupying processes still remain undiscovered , especially if they present only slight symptoms or imitate typical different diseases ." ], "offsets": [ [ 0, 266 ] ] } ]	[ { "id": "DerSchmerz.70110263.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "imaging" ], "offsets": [ [ 37, 44 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011923" } ] }, { "id": "DerSchmerz.70110263.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "posterior" ], "offsets": [ [ 49, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032009" } ] }, { "id": "DerSchmerz.70110263.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "magnetic" ], "offsets": [ [ 68, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024488" } ] }, { "id": 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], "offsets": [ [ 68, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0917874" } ] }, { "id": "DerSchmerz.70110263.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "magnetic resonance imaging" ], "offsets": [ [ 68, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024485" } ] } ]	[]	[]	[ { "id": "DerSchmerz.70110263.eng.abstr-s1-r1-t7.1-t3.1", "type": "issue_in", "arg1_id": "DerSchmerz.70110263.eng.abstr-s1-t7", "arg2_id": "DerSchmerz.70110263.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerSchmerz.70110263.eng.abstr-s1-r2-t2.1-t7.1", "type": "location_of", "arg1_id": "DerSchmerz.70110263.eng.abstr-s1-t2", "arg2_id": "DerSchmerz.70110263.eng.abstr-s1-t7", "normalized": [] }, { "id": "DerSchmerz.70110263.eng.abstr-s1-r3-t7.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110263.eng.abstr-s1-t7", "arg2_id": "DerSchmerz.70110263.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerSchmerz.70110263.eng.abstr-s1-r4-t2.1-t1.1", "type": "location_of", "arg1_id": 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DerSchmerz.70110305.eng.abstr	DerSchmerz.70110305.eng.abstr	[ { "id": "DerSchmerz.70110305.eng.abstr-passage-0", "type": "abstract", "text": [ "This article reviews the empirical research which has examined the relationships among chronic pain and cognitions like attributions , coping , beliefs , expectations and problem solving . Methods for the examination of pain cognitions and coping strategies are reviewed . Current research which shows the significance of cognitions and coping for the chronification of pain states is reported . These findings are critically discussed . Other methods for future research are presented ." ], "offsets": [ [ 0, 487 ] ] } ]	[ { "id": "DerSchmerz.70110305.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "research" ], "offsets": [ [ 35, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "DerSchmerz.70110305.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 95, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110305.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cognitions" ], "offsets": [ [ 104, 114 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009240" } ] }, { "id": "DerSchmerz.70110305.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "beliefs" ], "offsets": [ [ 144, 151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004951" } ] }, { "id": "DerSchmerz.70110305.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "empirical research" ], "offsets": [ [ 25, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376367" 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"type": "umlsterm", "text": [ "research" ], "offsets": [ [ 463, 471 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] } ]	[]	[]	[ { "id": "DerSchmerz.70110305.eng.abstr-s1-r1-t4.1-t3.1", "type": "result_of", "arg1_id": "DerSchmerz.70110305.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.70110305.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerSchmerz.70110305.eng.abstr-s1-r2-t5.1-t4.1", "type": "measures", "arg1_id": "DerSchmerz.70110305.eng.abstr-s1-t5", "arg2_id": "DerSchmerz.70110305.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.70110305.eng.abstr-s1-r3-t1.1-t4.1", "type": "measures", "arg1_id": "DerSchmerz.70110305.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.70110305.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.70110305.eng.abstr-s1-r4-t2.1-t4.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.70110305.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.70110305.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.70110305.eng.abstr-s1-r5-t4.1-t3.1", 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DerSchmerz.70110314.eng.abstr	DerSchmerz.70110314.eng.abstr	[ { "id": "DerSchmerz.70110314.eng.abstr-passage-0", "type": "abstract", "text": [ "Chronic pain has a variety of causes . Therefore patients with chronic pain should be treated in an interdisciplinary way . From a psychological point of view a cognitive-behavioral approach is preferred . This includes training for coping with pain as well as the added option of a comprehensive psychotherapy . This form of treatment seems to be indicated in most cases , but it is not suitable if the patient does not agree with the procedure , preferring instead a special kind of therapy which is not cognitive-behavioral . On the other hand a psychological treatment is not indicated if the therapist is not prepared to cooperate with other therapists in an interdisciplinary fashion ." ], "offsets": [ [ 0, 691 ] ] } ]	[ { "id": "DerSchmerz.70110314.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 8, 12 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "causes" ], "offsets": [ [ 30, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 49, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 71, 75 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "training" ], "offsets": [ [ 220, 228 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040607" }, { "db_name": "UMLS", "db_id": "C0220931" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 245, 249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "psychotherapy" ], "offsets": [ [ 297, 310 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033968" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "form" ], "offsets": [ [ 318, 322 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376315" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 326, 335 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 404, 411 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "procedure" ], "offsets": [ [ 436, 445 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 485, 492 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "hand" ], "offsets": [ [ 542, 546 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "DerSchmerz.70110314.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 563, 572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]	[]	[]	[ { "id": "DerSchmerz.70110314.eng.abstr-s4-r1-t3.1-t1.1", "type": "treats", "arg1_id": "DerSchmerz.70110314.eng.abstr-s5-t3", "arg2_id": "DerSchmerz.70110314.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerSchmerz.70110314.eng.abstr-s5-r1-t1.1-t5.1", "type": "performs", "arg1_id": "DerSchmerz.70110314.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.70110314.eng.abstr-s5-t5", "normalized": [] }, { "id": "DerSchmerz.70110314.eng.abstr-s5-r2-t4.1-t5.1", "type": "conceptual_part_of", "arg1_id": "DerSchmerz.70110314.eng.abstr-s5-t4", "arg2_id": "DerSchmerz.70110314.eng.abstr-s5-t5", "normalized": [] }, { "id": "DerSchmerz.70110314.eng.abstr-s5-r3-t5.1-t1.1", "type": "uses", "arg1_id": "DerSchmerz.70110314.eng.abstr-s5-t5", "arg2_id": "DerSchmerz.70110314.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerSchmerz.70110314.eng.abstr-s5-r4-t2.1-t1.1", "type": "uses", "arg1_id": "DerSchmerz.70110314.eng.abstr-s6-t2", "arg2_id": "DerSchmerz.70110314.eng.abstr-s6-t1", "normalized": [] }, { "id": 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DerSchmerz.70110322.eng.abstr	DerSchmerz.70110322.eng.abstr	[ { "id": "DerSchmerz.70110322.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Headache is thought to be generated by nociceptive processes within the meninges , followed by activation of trigeminal neurons within the brainstem . The noxious stimuli initially involved in these nociceptive processes are unknown . A preparation was developed in the barbiturate-anesthetized rat , in which the activation of trigeminal brain stem neurons by selective local stimulation of the dura mater could be observed ." ], "offsets": [ [ 0, 441 ] ] } ]	[ { "id": "DerSchmerz.70110322.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Headache" ], "offsets": [ [ 15, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.70110322.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "meninges" ], "offsets": [ [ 87, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025285" }, { "db_name": "UMLS", "db_id": "C0348375" } ] }, { "id": "DerSchmerz.70110322.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "neurons" ], "offsets": [ [ 135, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027882" } ] }, { "id": "DerSchmerz.70110322.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "brainstem" ], "offsets": [ [ 154, 163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006121" } ] }, { "id": "DerSchmerz.70110322.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "rat" ], "offsets": [ [ 310, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034693" } ] }, { "id": "DerSchmerz.70110322.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "brain" ], "offsets": [ [ 354, 359 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0153633" }, { "db_name": "UMLS", "db_id": "C0006104" }, { "db_name": "UMLS", "db_id": "C0496899" } ] }, { "id": "DerSchmerz.70110322.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "neurons" ], "offsets": [ [ 365, 372 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027882" } ] }, { "id": "DerSchmerz.70110322.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "brain stem" ], "offsets": [ [ 354, 364 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006121" } ] }, { "id": "DerSchmerz.70110322.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "dura mater" ], "offsets": [ [ 411, 421 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013313" } ] } ]	[]	[]	[ { "id": "DerSchmerz.70110322.eng.abstr-s1-r2-t4.1-t2.2", "type": "adjacent_to", "arg1_id": "DerSchmerz.70110322.eng.abstr-s3-t4", "arg2_id": "DerSchmerz.70110322.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerSchmerz.70110322.eng.abstr-s1-r3-t2.2-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110322.eng.abstr-s3-t2", "arg2_id": "DerSchmerz.70110322.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerSchmerz.70110322.eng.abstr-s1-r5-t4.1-t2.2", "type": "location_of", "arg1_id": "DerSchmerz.70110322.eng.abstr-s3-t4", "arg2_id": "DerSchmerz.70110322.eng.abstr-s3-t2", "normalized": [] }, { "id": "DerSchmerz.70110322.eng.abstr-s1-r6-t2.2-t4.1", "type": "adjacent_to", "arg1_id": "DerSchmerz.70110322.eng.abstr-s3-t2", "arg2_id": "DerSchmerz.70110322.eng.abstr-s3-t4", "normalized": [] }, { "id": "DerSchmerz.70110322.eng.abstr-s1-r8-t1.1-t2.2", "type": "associated_with", "arg1_id": "DerSchmerz.70110322.eng.abstr-s3-t1", "arg2_id": 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DerSchmerz.70110328.eng.abstr	DerSchmerz.70110328.eng.abstr	[ { "id": "DerSchmerz.70110328.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : \" Pain under Discussion \" aims at the education of patients with chronic headache and back pain by applying a standardized manual with detailed instructions for seven sessions in a group setting . Apart from encouraging a reconceptualization of the patients ' pain experience with reference to a bio-psycho-social model , the program provides information about the vicious circle of pain , avoidance and demoralization and relies heavily on behavioral assumptions about the process of chronicity . Patients are offered participation in progressive relaxation according to Jacobson , they learn to engage in pleasant activities , and are instructed to more and more maintain an upright body position during various activities of every day life . The study evaluates the outcome of the training . Moreover , as an algorithm for grading pain patients according to their level of chronicity has recently been developed by Gerbershagen , we use this algorithm in order to investigate the relationship between the outcome of treatment and the assigned level of chronicity . In addition , we test the assumption that a higher level of chronicity is related to a lower level of psychological functioning pre treatment ." ], "offsets": [ [ 0, 1221 ] ] } ]	[ { "id": "DerSchmerz.70110328.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Pain" ], "offsets": [ [ 12, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "education" ], "offsets": [ [ 48, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013621" }, { "db_name": "UMLS", "db_id": "C0013622" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 61, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "headache" ], "offsets": [ [ 83, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 101, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "manual" ], "offsets": [ [ 133, 139 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024763" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "instructions" ], "offsets": [ [ 154, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302828" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "chronic headache" ], "offsets": [ [ 75, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0151293" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "back pain" ], "offsets": [ [ 96, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004604" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "education of patients" ], "offsets": [ [ 48, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030688" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 259, 267 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 270, 274 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "program" ], "offsets": [ [ 336, 343 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376691" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 393, 397 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 508, 516 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "relaxation" ], "offsets": [ [ 558, 568 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035028" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "life" ], "offsets": [ [ 748, 752 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "body position" ], "offsets": [ [ 695, 708 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032818" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "training" ], "offsets": [ [ 794, 802 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040607" }, { "db_name": "UMLS", "db_id": "C0220931" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "algorithm" ], "offsets": [ [ 822, 831 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002045" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 844, 848 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 849, 857 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "algorithm" ], "offsets": [ [ 955, 964 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002045" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1029, 1038 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110328.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1210, 1219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] 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"DerSchmerz.70110328.eng.abstr-s5-t5", "arg2_id": "DerSchmerz.70110328.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerSchmerz.70110328.eng.abstr-s5-r4-t3.1-t4.1", "type": "uses", "arg1_id": "DerSchmerz.70110328.eng.abstr-s5-t3", "arg2_id": "DerSchmerz.70110328.eng.abstr-s5-t4", "normalized": [] }, { "id": "DerSchmerz.70110328.eng.abstr-s5-r5-t3.1-t1.1", "type": "uses", "arg1_id": "DerSchmerz.70110328.eng.abstr-s5-t3", "arg2_id": "DerSchmerz.70110328.eng.abstr-s6-t1", "normalized": [] } ]
DerSchmerz.70110339.eng.abstr	DerSchmerz.70110339.eng.abstr	[ { "id": "DerSchmerz.70110339.eng.abstr-passage-0", "type": "abstract", "text": [ "2-adrenergic agonists , mimicking the action of the inhibitory transmitter norepinephrine , cause antinociception due to postsynaptic inhibition of spinothalamic projection neurons , presynaptic inhibition at the central nervous system termination of primary sensory nerves , presynaptic inhibition of brainstem noradrenergic neurons and a generalized decrease in central nervous system sympathetic efferent activity . There is a mutual potentiation of antinociceptive effects of clonidine and morphine . Clonidine is used in chronic pain states for treatment of neuropathic , neuralgic and deafferentiating pain . Based on a meta-analysis of the studies published in the years 1996-1996 , the therapeutic efficacy of systematically administered clonidine was evaluated in chronic pain states . Out of 403 screened published studies , only 9 fulfilled the selection criteria . Besides three case reports with successful clonidine treatment , four placebo-controlled studies could be analyzed treating the following chronic pain states : chest pain despite normal coronary angiograms ; painful diabetic neuropathy ; postherpetic neuralgia ; hyperalgia in patients with sympathetically maintained pain and chronic low back pain . Although three studies demonstrated statistically significant improvement in pain scores , the improvement in pain relief in these cases was slight . Long-term treatment was successful in a few responders over a period of 17 months . Hyperalgesia caused by sympathetically maintained pain was relieved by topical ( transdermal ) application of clonidine . Based on this evaluation a grade C recommendation is derived , which relates to responders . Successful treatment is expected only in pain states with increased sympathetic nervous system activity . Therefore , in chronic pain , treatment with systemic clonidine is of no significant value ." ], "offsets": [ [ 0, 1875 ] ] } ]	[ { "id": "DerSchmerz.70110339.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "agonists" ], "offsets": [ [ 13, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243192" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "norepinephrine" ], "offsets": [ [ 75, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028351" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cause" ], "offsets": [ [ 92, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "inhibition" ], "offsets": [ [ 134, 144 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021467" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "projection" ], "offsets": [ [ 162, 172 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033363" }, { "db_name": "UMLS", "db_id": "C0016538" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "neurons" ], "offsets": [ [ 173, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027882" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "inhibition" ], "offsets": [ [ 195, 205 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021467" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "nervous" ], "offsets": [ [ 221, 228 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "nerves" ], "offsets": [ [ 267, 273 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "inhibition" ], "offsets": [ [ 288, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021467" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "brainstem" ], "offsets": [ [ 302, 311 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006121" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "noradrenergic" ], "offsets": [ [ 312, 325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013089" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "neurons" ], "offsets": [ [ 326, 333 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027882" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t14", "type": "umlsterm", "text": [ "nervous" ], "offsets": [ [ 372, 379 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t15", "type": "umlsterm", "text": [ "nervous system" ], "offsets": [ [ 221, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027763" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s1-t16", 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DerSchmerz.70110345.eng.abstr	DerSchmerz.70110345.eng.abstr	[ { "id": "DerSchmerz.70110345.eng.abstr-passage-0", "type": "abstract", "text": [ "Objective . To provide a brief review of the current state of topical treatment with capsaicin or acetylsalicylic acid ( ASA ) for therapy of chronic pain syndromes ." ], "offsets": [ [ 0, 166 ] ] } ]	[ { "id": "DerSchmerz.70110345.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objective" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerSchmerz.70110345.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "review" ], "offsets": [ [ 31, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282443" } ] }, { "id": "DerSchmerz.70110345.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 70, 79 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110345.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "capsaicin" ], "offsets": [ [ 85, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006931" } ] }, { "id": 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DerSchmerz.70110378.eng.abstr	DerSchmerz.70110378.eng.abstr	[ { "id": "DerSchmerz.70110378.eng.abstr-passage-0", "type": "abstract", "text": [ "This paper reviews instruments in German language for the psychological assessment and classification of pain . Usually chronic pain syndromes are classified within the International Classification of Diseases ( ICD ) . Instead of the psychiatric chapter of the ICD , it is possible to use the Diagnostic and Statistical Manual of Mental Disorders ( DSM ) . The proposed classification system of the International Association of the Study of Pain ( IASP ) is based on a multiaxial solution . The numerous ways to classify chronic pain include many problems and limits , especially in the case of an interdisciplinary assessment . They provide no specific system for classifying pain syndromes . They are impractical to handle and restrict classifying pain as either somatogenic or psychogenic . It is not possible to describe both sides in one diagnosis without loss of information . As a result of this situation , a task force of the German Chapter of the International Association for the Study of Pain developed a Multiaxial Classification of Pain ( Multiaxiale Schmerzklassifikation ; MASK ) as an advanced system of pain assessment and an alternative to the common classification systems . MASK embraces a somatic ( MASK-S ) and a psychological ( MASK-P ) part. Both parts constitute an ' interdisciplinary diagnosis ' . MASK-S enables classifying a pain syndrome using hierarchical levels , with progredient specific degrees of differentiation . In addition there are 6 axes to describe pain syndromes qualitatively and quantitatively ( e.g. localization , quality ) . The psychosocial part ( MASK-P ) embraces 5 main levels ( 1. behavioral , 2. emotional , 3. cognitive , 4. stress-related , 5. habitual personal factors ) and 2 additional levels ( 6. functional coherence , 7. ICD/DSM-diagnosis additional ) . The MASK-P part of the diagnosis is composed of graduation on these levels . Differential axis of the pain syndromes are described phenomenologically and specifically . MASK provides the possibility of establishing an integrative , interdisciplinary diagnosis ." ], "offsets": [ [ 0, 2080 ] ] } ]	[ { "id": "DerSchmerz.70110378.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "paper" ], "offsets": [ [ 5, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030351" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "instruments" ], "offsets": [ [ 19, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243113" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "language" ], "offsets": [ [ 41, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023008" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 72, 82 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "classification" ], "offsets": [ [ 87, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 105, 109 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 128, 132 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 133, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "Classification" ], "offsets": [ [ 183, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "Diseases" ], "offsets": [ [ 201, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "pain syndromes" ], "offsets": [ [ 128, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0391976" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Diagnostic" ], "offsets": [ [ 294, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "Manual" ], "offsets": [ [ 321, 327 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024763" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "Disorders" ], "offsets": [ [ 338, 347 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "DSM" ], "offsets": [ [ 350, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011777" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "Mental Disorders" ], "offsets": [ [ 331, 347 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004936" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "classification" ], "offsets": [ [ 371, 385 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "Association" ], "offsets": [ [ 414, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004083" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "Pain" ], "offsets": [ [ 442, 446 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110378.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "solution" ], "offsets": [ [ 481, 489 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037633" } ] }, { "id": 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In this study a German version of a self-reporting instrument that assesses fear-avoidance beliefs ( FABQ , Waddell et al. 1993 ) is presented ." ], "offsets": [ [ 0, 881 ] ] } ]	[ { "id": "DerSchmerz.70110387.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "back" ], "offsets": [ [ 127, 131 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004600" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 132, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "costs" ], "offsets": [ [ 171, 176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010186" }, { "db_name": "UMLS", "db_id": "C0010181" }, { "db_name": "UMLS", "db_id": "C0220812" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "strain" ], "offsets": [ [ 189, 195 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0080194" } ] }, { "id": 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"health care systems" ], "offsets": [ [ 199, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018696" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "costs" ], "offsets": [ [ 247, 252 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010186" }, { "db_name": "UMLS", "db_id": "C0010181" }, { "db_name": "UMLS", "db_id": "C0220812" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 263, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 372, 376 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "chronic illnesses" ], "offsets": [ [ 277, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008679" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s3-t1", "type": 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DerSchmerz.70110396.eng.abstr	DerSchmerz.70110396.eng.abstr	[ { "id": "DerSchmerz.70110396.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : A pilot study was conducted to provide an indication of the power density ( PD ) dependent analgesic effect of ultrasound ( US ) under serial application in patients with low back pain ." ], "offsets": [ [ 0, 201 ] ] } ]	[ { "id": "DerSchmerz.70110396.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "power" ], "offsets": [ [ 75, 80 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032863" } ] }, { "id": "DerSchmerz.70110396.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "analgesic" ], "offsets": [ [ 106, 115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.70110396.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "ultrasound" ], "offsets": [ [ 126, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220934" }, { "db_name": "UMLS", "db_id": "C0041618" }, { "db_name": "UMLS", 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DerSchmerz.70110411.eng.abstr	DerSchmerz.70110411.eng.abstr	[ { "id": "DerSchmerz.70110411.eng.abstr-passage-0", "type": "abstract", "text": [ "Anticonvulsive drugs provide good analgesic effect in the treatment of chronic neuropathic pain syndromes as well as in certain types of headache . Moreover these drugs may also be considered helpful for cases of non-neuropathic pain , especially if non-opioid analgesics are not effective ." ], "offsets": [ [ 0, 291 ] ] } ]	[ { "id": "DerSchmerz.70110411.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "drugs" ], "offsets": [ [ 15, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.70110411.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "analgesic" ], "offsets": [ [ 34, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.70110411.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 58, 67 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110411.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 91, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110411.eng.abstr-s1-t5", 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"DerSchmerz.70110411.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.70110411.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.70110411.eng.abstr-s2-r3-t4.1-t2.1", "type": "treats", "arg1_id": "DerSchmerz.70110411.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.70110411.eng.abstr-s2-t2", "normalized": [] } ]
DerSchmerz.80120001.eng.abstr	DerSchmerz.80120001.eng.abstr	[ { "id": "DerSchmerz.80120001.eng.abstr-passage-0", "type": "abstract", "text": [ "The Dutch Supreme Court ruled that in exceptional instances , physician-assisted suicide might be justifiable for patients with unbearable mental suffering but no physical illness . A recent report shows that explicit requests for physician-assisted suicide are not uncommon in psychiatric practice in the Netherlands . Some of those requests were granted and their medical background was described . Psychiatric consultation for medical patients who request physician-assisted suicide is relatively rare ." ], "offsets": [ [ 0, 506 ] ] } ]	[ { "id": "DerSchmerz.80120001.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "suicide" ], "offsets": [ [ 81, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038661" } ] }, { "id": "DerSchmerz.80120001.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 114, 122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.80120001.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "physician-assisted suicide" ], "offsets": [ [ 62, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162664" } ] }, { "id": "DerSchmerz.80120001.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "suicide" ], "offsets": [ [ 250, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038661" } ] }, { "id": "DerSchmerz.80120001.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "Netherlands" ], "offsets": [ [ 306, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027778" } ] }, { "id": "DerSchmerz.80120001.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "physician-assisted suicide" ], "offsets": [ [ 231, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162664" } ] }, { "id": "DerSchmerz.80120001.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "consultation" ], "offsets": [ [ 413, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009818" } ] }, { "id": "DerSchmerz.80120001.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 438, 446 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.80120001.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "suicide" ], "offsets": [ [ 478, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038661" } ] }, { "id": "DerSchmerz.80120001.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "physician-assisted suicide" ], "offsets": [ [ 459, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162664" } ] } ]	[]	[]	[ { "id": "DerSchmerz.80120001.eng.abstr-s1-r1-t2.1-t1.1", "type": "performs", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s1-r2-t3.1-t2.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t3", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s1-r3-t1.1-t2.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s1-r4-t2.1-t3.1", "type": "performs", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s2-r1-t2.1-t3.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s2-r2-t2.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s2-r3-t3.1-t2.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t3", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s2-r4-t1.1-t2.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s4-r1-t1.1-t4.1", "type": "performs", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t4", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s4-r2-t4.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t4", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s4-r3-t1.1-t3.1", "type": "performs", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerSchmerz.80120001.eng.abstr-s4-r4-t3.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120001.eng.abstr-s4-t3", "arg2_id": "DerSchmerz.80120001.eng.abstr-s4-t1", "normalized": [] } ]
DerSchmerz.80120008.eng.abstr	DerSchmerz.80120008.eng.abstr	[ { "id": "DerSchmerz.80120008.eng.abstr-passage-0", "type": "abstract", "text": [ "Widespread pain syndromes of the musculoskeletal system present to general practitionas , internists , neurologists and orthopedic surgeons every day . The syndromes may result both from organic diseases ( inflammatory joint diseases , rheumatic manifestations of organ diseases ) as well as dysfunctional syndromes , the latter including mainly biomechanically induced syndromes and fibromyalgia . The approach is predominantly clinically oriented and requires laboratory means or technical procedures only in a limited extend . The duration of history , the recognition of synovitis and of myofascial trigger points or of integumental tender points allow in most patients to achieve appropriate diagnostic criteria ." ], "offsets": [ [ 0, 718 ] ] } ]	[ { "id": "DerSchmerz.80120008.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 11, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120008.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 16, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerSchmerz.80120008.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "orthopedic" ], "offsets": [ [ 120, 130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029355" } ] }, { "id": "DerSchmerz.80120008.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain syndromes" ], "offsets": [ [ 11, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0391976" } ] }, { "id": "DerSchmerz.80120008.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "musculoskeletal system" ], "offsets": [ [ 33, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026860" } ] }, { "id": "DerSchmerz.80120008.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 156, 165 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerSchmerz.80120008.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 195, 203 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.80120008.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "joint" ], "offsets": [ [ 219, 224 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "DerSchmerz.80120008.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 225, 233 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.80120008.eng.abstr-s2-t5", "type": "umlsterm", "text": [ 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DerSchmerz.80120012.eng.abstr	DerSchmerz.80120012.eng.abstr	[ { "id": "DerSchmerz.80120012.eng.abstr-passage-0", "type": "abstract", "text": [ "Commonly pain has been seen as a warning sign reacting to a source of pain . This process displays the wisdom of the body and its ability to function well . But this concept cannot necessarily be upheld when , due to illness , integrity of the body can be neither the presupposition nor the goal of treatment . The ethical question is not to decide which perspective ( pain as a vital sign or pain as catastrophe ) is the dominant one . Medical ethics must acknowledge pain as a process of human destruction , and it must interpret the treatment of pain as an endeavour which makes life possible again , or strengthens its remaining elements . When pain goes beyond the resources of the human being to form his/her life , the border between meaningful and meaningless pain is crossed . A case from an obstetrical ward is used to demonstrate three central principles of the treatment of pain : ( 1 ) Understanding the pain as the end of all interests , as making life a burden or as evacuating the ego . 2. Respect of the autonomy of the patient by informing him/her about the experiences which he/she gets rid of during analgesia , or by establishing the possibilities that PCA or time-contingent medication offer . 3. The multidimensional therapy of pain : i.e. all groups of caregivers must be involved , because it is not important to know which perspective is the best , but that no single perspective can stand alone . These principles must be taken into account even when the possibilities of effective pain relief are exhausted . Sometimes the debate on the practice of euthanasia seems to replace the medical goal of honest treatment of the patient's pain ." ], "offsets": [ [ 0, 1665 ] ] } ]	[ { "id": "DerSchmerz.80120012.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 9, 13 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120012.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "sign" ], "offsets": [ [ 41, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220912" } ] }, { "id": "DerSchmerz.80120012.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 70, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120012.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "ability" ], "offsets": [ [ 130, 137 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085732" } ] }, { "id": "DerSchmerz.80120012.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "goal" ], "offsets": [ [ 291, 295 ] ], 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The metaanalysis provides no evidence of intrinsic analgesic properties of neuroleptics for their use as adjuvant analgesics ." ], "offsets": [ [ 0, 876 ] ] } ]	[ { "id": "DerSchmerz.80120030.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 20, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerSchmerz.80120030.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "neuroleptics" ], "offsets": [ [ 45, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040615" } ] }, { "id": "DerSchmerz.80120030.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "drugs" ], "offsets": [ [ 65, 70 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.80120030.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 78, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120030.eng.abstr-s1-t5", "type": 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DerSchmerz.80120105.eng.abstr	DerSchmerz.80120105.eng.abstr	[ { "id": "DerSchmerz.80120105.eng.abstr-passage-0", "type": "abstract", "text": [ "Aim : This review article focuses on a possible pain-alleviating effect of shock-wave application in persistent lateral epicondylopathy of the elbow and compares the effects with data on other non-operative and operative procedures ." ], "offsets": [ [ 0, 233 ] ] } ]	[ { "id": "DerSchmerz.80120105.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "review" ], "offsets": [ [ 11, 17 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282443" } ] }, { "id": "DerSchmerz.80120105.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "shock-wave" ], "offsets": [ [ 75, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036974" } ] }, { "id": "DerSchmerz.80120105.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "elbow" ], "offsets": [ [ 143, 148 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013769" } ] }, { "id": "DerSchmerz.80120105.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 221, 231 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120105.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "operative procedures" ], "offsets": [ [ 211, 231 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] } ]	[]	[]	[ { "id": "DerSchmerz.80120105.eng.abstr-s1-r1-t4.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120105.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120105.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerSchmerz.80120105.eng.abstr-s1-r2-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120105.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.80120105.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120105.eng.abstr-s1-r3-t3.1-t4.1", "type": "location_of", "arg1_id": "DerSchmerz.80120105.eng.abstr-s1-t3", "arg2_id": "DerSchmerz.80120105.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120105.eng.abstr-s1-r4-t3.1-t1.1", "type": "location_of", "arg1_id": "DerSchmerz.80120105.eng.abstr-s1-t3", "arg2_id": "DerSchmerz.80120105.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerSchmerz.80120105.eng.abstr-s1-r5-t4.1-t3.1", "type": "measurement_of", "arg1_id": "DerSchmerz.80120105.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120105.eng.abstr-s1-t3", "normalized": [] } ]
DerSchmerz.80120112.eng.abstr	DerSchmerz.80120112.eng.abstr	[ { "id": "DerSchmerz.80120112.eng.abstr-passage-0", "type": "abstract", "text": [ "Prostaglandin synthesis inhibitors and parasympatholytic drugs are often used as analgetics in the case of renal colic . This paper analyzes how and whether these drug effects are important for the analgetic therapy . In an animal and in a human model with acutely obstructed kidneys we found that intravenous application of Indometacine and dipyrone significantly reduces renal pelvic pressure . The parasympatholytic drug hyoscine butylbromide did not produce any change of upper urinary tract dynamics . Inhibitors of prostaglandin synthesis thus effect pressure reduction in the renal pelvis , which is necessary for analgetic therapy . In contrast , hyoscine butylbromide does not have any influence on the acute upper urinary tract obstruction ; consequently its usefulness in the treatment of renal colic is rather doubtful ." ], "offsets": [ [ 0, 832 ] ] } ]	[ { "id": "DerSchmerz.80120112.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Prostaglandin" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033554" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "inhibitors" ], "offsets": [ [ 24, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243077" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "parasympatholytic" ], "offsets": [ [ 39, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030511" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "drugs" ], "offsets": [ [ 57, 62 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "analgetics" ], "offsets": [ [ 81, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "colic" ], "offsets": [ [ 113, 118 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009281" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "parasympatholytic drugs" ], "offsets": [ [ 39, 62 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030511" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "paper" ], "offsets": [ [ 126, 131 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030351" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 163, 167 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "analgetic" ], "offsets": [ [ 198, 207 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 208, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "drug effects" ], "offsets": [ [ 163, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0728866" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "animal" ], "offsets": [ [ 224, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "human" ], "offsets": [ [ 240, 245 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "kidneys" ], "offsets": [ [ 276, 283 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022646" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "dipyrone" ], "offsets": [ [ 342, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012586" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 386, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "parasympatholytic" ], "offsets": [ [ 401, 418 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030511" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 419, 423 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "hyoscine" ], "offsets": [ [ 424, 432 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036442" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "butylbromide" ], "offsets": [ [ 433, 445 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0626371" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "butylbromide" ], "offsets": [ [ 433, 445 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006222" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "parasympatholytic drug" ], "offsets": [ [ 401, 423 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030511" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "urinary tract" ], "offsets": [ [ 482, 495 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042027" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Inhibitors" ], "offsets": [ [ 507, 517 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243077" } ] }, { 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We postulate that the two personality factors correlate with postoperative parameters of pain and that there are also multiple correlations between them ." ], "offsets": [ [ 0, 902 ] ] } ]	[ { "id": "DerSchmerz.80120118.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 76, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "cholecystectomy" ], "offsets": [ [ 109, 124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008320" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "clinical trial" ], "offsets": [ [ 58, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008976" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "controlled clinical trial" ], "offsets": [ [ 47, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009933" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "personality" ], "offsets": [ [ 175, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031208" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "self-efficacy" ], "offsets": [ [ 197, 210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600564" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "self-efficacy" ], "offsets": [ [ 197, 210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036588" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "control" ], "offsets": [ [ 224, 231 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243148" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "postoperative" ], "offsets": [ [ 256, 269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032790" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 270, 274 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "postoperative pain" ], "offsets": [ [ 256, 274 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030201" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "locus of control" ], "offsets": [ [ 215, 231 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023953" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Self-efficacy" ], "offsets": [ [ 277, 290 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600564" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "Self-efficacy" ], "offsets": [ [ 277, 290 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036588" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "person" ], "offsets": [ [ 323, 329 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027361" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "behavior" ], "offsets": [ [ 358, 366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004927" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "control" ], "offsets": [ [ 418, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243148" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "personality" ], "offsets": [ [ 455, 466 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031208" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "orientation" ], "offsets": [ [ 510, 521 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029266" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "rewards" ], "offsets": [ [ 560, 567 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035397" } ] }, { "id": "DerSchmerz.80120118.eng.abstr-s4-t5", "type": 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Particularly physicians with a purely biological concept of pain have not learned to take note of affective relational factors and incorporate them into their diagnostic assessment . The decision to undertake invasive diagnostic or therapeutic procedures then frequently represents the doctor's reaction to feelings of irritation or helplessness . If this situation is to change , an interdisciplinary concept of pain must be made a part of medical training , and scientific findings must be presented in such a way that they can be integrated into routine daily practice ." ], "offsets": [ [ 0, 1406 ] ] } ]	[ { "id": "DerSchmerz.80120130.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 29, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 34, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "measures" ], "offsets": [ [ 52, 60 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079809" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "standards" ], "offsets": [ [ 81, 90 ] ], "normalized": [ { "db_name": 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DerSchmerz.80120136.eng.abstr	DerSchmerz.80120136.eng.abstr	[ { "id": "DerSchmerz.80120136.eng.abstr-passage-0", "type": "abstract", "text": [ "Disregarding pain resulting from vitamin deficiency , an analgesic effect seems to be exerted only by vitamin B1 ( thiamine ) , vitamin B6 ( pyridoxines ) , and vitamin B12 ( cobalamine ) , particularly when the three are given in combination . The analgesic effect is attributed to an increased availability and/or effectiveness of noradrenaline and 5-hydroxytryptamine acting as inhibitory transmitters in the nociceptive system ." ], "offsets": [ [ 0, 432 ] ] } ]	[ { "id": "DerSchmerz.80120136.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 13, 17 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "vitamin" ], "offsets": [ [ 33, 40 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "deficiency" ], "offsets": [ [ 41, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011155" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "analgesic" ], "offsets": [ [ 57, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "vitamin" ], "offsets": [ [ 102, 109 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "thiamine" ], "offsets": [ [ 115, 123 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039840" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "vitamin" ], "offsets": [ [ 128, 135 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "vitamin" ], "offsets": [ [ 161, 168 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "cobalamine" ], "offsets": [ [ 175, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086024" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "vitamin deficiency" ], "offsets": [ [ 33, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376286" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "vitamin B1" ], "offsets": [ [ 102, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039840" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "vitamin B6" ], "offsets": [ [ 128, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087162" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "vitamin B12" ], "offsets": [ [ 161, 172 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042845" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "analgesic" ], "offsets": [ [ 249, 258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.80120136.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "noradrenaline" ], "offsets": [ [ 333, 346 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028351" } ] }, 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DerSchmerz.80120142.eng.abstr	DerSchmerz.80120142.eng.abstr	[ { "id": "DerSchmerz.80120142.eng.abstr-passage-0", "type": "abstract", "text": [ "Weak opioids have a maximal dose ( ceiling effect ) , and their distribution and prescription is not controlled by German narcotic laws . In a literature search ( Medline 1963- 1995 ) and our own literature database on pain treatment , 58 publications were identified . These reported about 130 comparisons of weak opioids with different analgesics . The statistical parameters of a meta-analysis were not calculated , due to great differences of the study design and the examined drugs . The results of this literature analysis demonstrate the analgesic efficacy of weak opioids in chronic pain . Non-opioid analgesics and strong opioids , however , have greater potency . These results are based mainly on single-dose studies ; controlled long-term studies are required . Especially the risk of serious complications involving the gastrointestinal tract , kidney and blood cells during long-term treatment with non-opioid analgesics or weak opioids needs to be evaluated . In addition , the combination of non-opioid analgesics and weak opioids versus the combination of nonopioid analgesics and placebo or low-dose strong opioids has to be investigated . The results of this literature analysis support the use of weak opioids in the symptomatic treatment of chronic pain , though the evidence of the available literature is limited . It can be recommended to prescribe weak opioids according to the WHO ladder in combination with non-opioid analgesics . If this combination provides no adequate analgesic efficacy , however , the use of strong opioids must not be delayed ." ], "offsets": [ [ 0, 1577 ] ] } ]	[ { "id": "DerSchmerz.80120142.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "opioids" ], "offsets": [ [ 5, 12 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.80120142.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "distribution" ], "offsets": [ [ 64, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0520511" } ] }, { "id": "DerSchmerz.80120142.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "prescription" ], "offsets": [ [ 81, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033080" } ] }, { "id": "DerSchmerz.80120142.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "narcotic" ], "offsets": [ [ 122, 130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027415" } ] }, { "id": "DerSchmerz.80120142.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "laws" ], "offsets": [ [ 131, 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DerSchmerz.80120179.eng.abstr	DerSchmerz.80120179.eng.abstr	[ { "id": "DerSchmerz.80120179.eng.abstr-passage-0", "type": "abstract", "text": [ "With regard to the potentialities of hypnosis for the treatment of pain , relevant studies on hypnotic pain control are discussed . Studies with experimentally produced pain unanimously show that hypnosis is effective in controlling pain , whereas clinical studies are much more ambiguous in this respect . Three basic strategies of hypnotic pain control are outlined to which the different techniques can be subsumed : dissociative , associative , and symbolic strategies . Accountable for the limitations of hypnosis are some issues like hypnotic state , hypnotizability , rapport , hypnotic techniques , and pain as a multifactorial process . These issues are discussed and their contribution to contraindications are outlined . Especially the differences between symptom- and problem-oriented hypnotic approaches are highlighted ." ], "offsets": [ [ 0, 834 ] ] } ]	[ { "id": "DerSchmerz.80120179.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "hypnosis" ], "offsets": [ [ 37, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020587" } ] }, { "id": "DerSchmerz.80120179.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 54, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120179.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 67, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120179.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "hypnotic" ], "offsets": [ [ 94, 102 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020591" } ] }, { "id": "DerSchmerz.80120179.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "pain" ], 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DerSchmerz.80120195.eng.abstr	DerSchmerz.80120195.eng.abstr	[ { "id": "DerSchmerz.80120195.eng.abstr-passage-0", "type": "abstract", "text": [ "Hydromorphone is a µ receptor agonist opioid . According to WHO recommendations , hydromorphone is to be classified in step III of pain therapy . An oral formulation with a prolonged duration of action of 12 hours has been evaluated only recently . The controlled release capsule is especially suited for the regular twice a day administration in cases of severe and persistent pain . The oral formulation of hydromorphone increases the number of opioid analgesics available for pain therapy in step III . Hydromorphone is recommended when morphine fails to produce sufficient pain relief ( despite increase of doses ) or causes intolerable side effects ( despite treatment of symptoms ) . In principle , no differences in efficacy of morphine and hydromorphone are to be expected . However , clinical experience shows that changing one opioid analgesic to another one can improve the treatment of patients so that hydromorphone may replace another opioid analgesic to which a patient fails to respond well or develops side effects . The dose of hydromorphone equivalent to 2 times 30 mg controlled release morphine is about 2 times 4 mg . The values for the absorption , bioavailability and maximum plasma concentration after the administration of controlled release hydromorphone every 12 hours -of three times the dose- are equivalent to those of an immediate release tablet given every 4 hours . In several open label and controlled studies , hydromorphone proved to be of good efficacy in the treatment of acute and persistent pain , especially in patients with severe cancer pain . With regard to the incidence of side effects , no significant differences between morphine and hydromorphone could be established . In general , the side effects of hydromorphone are typical for opioid analgesics ." ], "offsets": [ [ 0, 1802 ] ] } ]	[ { "id": "DerSchmerz.80120195.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Hydromorphone" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012306" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "agonist" ], "offsets": [ [ 30, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243192" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "opioid" ], "offsets": [ [ 38, 44 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "recommendations" ], "offsets": [ [ 64, 79 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034866" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "hydromorphone" ], "offsets": [ [ 82, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012306" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 131, 135 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 136, 143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "pain therapy" ], "offsets": [ [ 131, 143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002766" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "release" ], "offsets": [ [ 264, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0541720" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "capsule" ], "offsets": [ [ 272, 279 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006935" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "administration" ], "offsets": [ [ 329, 343 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001554" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 378, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "hydromorphone" ], "offsets": [ [ 409, 422 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012306" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "opioid" ], "offsets": [ [ 447, 453 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "analgesics" ], "offsets": [ [ 454, 464 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s5-t4", "type": "umlsterm", 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DerSchmerz.80120205.eng.abstr	DerSchmerz.80120205.eng.abstr	[ { "id": "DerSchmerz.80120205.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : Comprehensive diagnosis of pain comprises assessment of subjectively felt pain as one necessary component . Modern approaches are multidimensional ( differentiation between sensory and affective parts ; multiple sub-aspects of sensory pain ) and go far beyond single-item-methods , whose utility remain questionable not only regarding the contents but for measurement purposes as well . One of these modern instruments of pain assessment , the Pain Experience Scale ( German : Schmerzempfindungsskala , SES ) , served as original for the development of a computerized version . The study aimed to establish whether this computer version is equivalent to the paper-pencil original ." ], "offsets": [ [ 0, 691 ] ] } ]	[ { "id": "DerSchmerz.80120205.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 24, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 37, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 52, 62 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 84, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 245, 249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "measurement" ], "offsets": [ [ 366, 377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242485" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "instruments" ], "offsets": [ [ 417, 428 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243113" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 432, 436 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 437, 447 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "Pain" ], "offsets": [ [ 454, 458 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "Scale" ], "offsets": [ [ 470, 475 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0175659" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 548, 559 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "pain assessment" ], "offsets": [ [ 432, 447 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030198" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "computer" ], "offsets": [ [ 630, 638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009622" } ] }, { "id": "DerSchmerz.80120205.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "paper-pencil" ], "offsets": [ [ 668, 680 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030351" } ] } 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DerSchmerz.80120209.eng.abstr	DerSchmerz.80120209.eng.abstr	[ { "id": "DerSchmerz.80120209.eng.abstr-passage-0", "type": "abstract", "text": [ "Disturbances of small afferent nerve fibres play an important role in painful neuropathies . Quantitative thermotest offers a possibility to quantify these disturbances that can not be detected by conventional electrophysiology . It is a psychophysical method to investigate thermal and nociceptive afferents by determinating thermal thresholds . Former experiences have shown that quantitative thermotest can be a helpful tool not only in daily routine but also for research work concerning pathophysiological mechanisms of neuropathy . Therefore a multicentric approach to investigate rare painful neuropathies seems to be useful ." ], "offsets": [ [ 0, 633 ] ] } ]	[ { "id": "DerSchmerz.80120209.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 31, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.80120209.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 62, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "DerSchmerz.80120209.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "thermotest" ], "offsets": [ [ 106, 116 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600510" }, { "db_name": "UMLS", "db_id": "C0013806" } ] }, { "id": "DerSchmerz.80120209.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "electrophysiology" ], "offsets": [ [ 210, 227 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013865" } ] }, { "id": "DerSchmerz.80120209.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "method" ], "offsets": [ [ 253, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120209.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "thermotest" ], "offsets": [ [ 395, 405 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600510" }, { "db_name": "UMLS", "db_id": "C0013806" } ] }, { "id": "DerSchmerz.80120209.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "research" ], "offsets": [ [ 467, 475 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "DerSchmerz.80120209.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "work" ], "offsets": [ [ 476, 480 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] } ]	[]	[]	[ { "id": "DerSchmerz.80120209.eng.abstr-s2-r1-t1.1-t2.1", "type": "affects", "arg1_id": "DerSchmerz.80120209.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.80120209.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.80120209.eng.abstr-s2-r2-t1.2-t2.1", "type": "affects", "arg1_id": "DerSchmerz.80120209.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.80120209.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.80120209.eng.abstr-s4-r1-t1.2-t3.1", "type": "isa", "arg1_id": "DerSchmerz.80120209.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.80120209.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerSchmerz.80120209.eng.abstr-s4-r2-t2.1-t3.1", "type": "isa", "arg1_id": "DerSchmerz.80120209.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.80120209.eng.abstr-s4-t3", "normalized": [] } ]
DerSchmerz.80120212.eng.abstr	DerSchmerz.80120212.eng.abstr	[ { "id": "DerSchmerz.80120212.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : This review of radiological and other procedures used in the diagnosis of ( chronic ) low-back pain is not intended to provide a complete evaluation of the methods employed , because the validity , specificity and sensitivity of the various diagnostic measures are the subject of so much controversy that a comprehensive discussion would be beyond the scope of the present overview . The choice of method depends not only on the clinical symptoms but also on the localisation of the pain , the aetiology of which may also be related to the age of the patient ." ], "offsets": [ [ 0, 573 ] ] } ]	[ { "id": "DerSchmerz.80120212.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "review" ], "offsets": [ [ 18, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282443" } ] }, { "id": "DerSchmerz.80120212.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 51, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120212.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "diagnosis" ], "offsets": [ [ 74, 83 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" }, { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerSchmerz.80120212.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 108, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120212.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "evaluation" ], "offsets": [ [ 151, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220825" } ] }, { "id": "DerSchmerz.80120212.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 169, 176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120212.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "specificity" ], "offsets": [ [ 211, 222 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037791" } ] }, { "id": "DerSchmerz.80120212.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "sensitivity" ], "offsets": [ [ 227, 238 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036667" } ] }, { "id": "DerSchmerz.80120212.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 254, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, 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This way normal levels of norepinephrine can cause pathological spontaneous activity of nociceptors which maintains the central sensitization . Chronic burning pain and cutaneous hyperalgesia may also be independent of the sympathetic innervation of the skin . In this case , central sensitization is maintained by other mechanisms . A role of the sympathetic nervous system in the pathogenesis of pain cannot be deduced simply from the simultaneous presence of sensory and autonomic clinical signs and symptoms . Therefore , sympathetic blockade in a patient initially is a diagnostic procedure , aiming to demonstrate the presence of the symptom SMP . Therapeutic blockade is only indicated after this demonstration . For the substantial number of patients with sympathetically independent pain , other treatment modalities are needed which may for example attack central sensitization ." ], "offsets": [ [ 0, 1668 ] ] } ]	[ { "id": "DerSchmerz.80120250.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 8, 12 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120250.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "extremity" ], "offsets": [ [ 25, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerSchmerz.80120250.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "dysfunction" ], "offsets": [ [ 68, 79 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031847" } ] }, { "id": "DerSchmerz.80120250.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "reflex" ], "offsets": [ [ 120, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034929" } ] }, { "id": "DerSchmerz.80120250.eng.abstr-s1-t5", "type": "umlsterm", 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DerSchmerz.80120272.eng.abstr	DerSchmerz.80120272.eng.abstr	[ { "id": "DerSchmerz.80120272.eng.abstr-passage-0", "type": "abstract", "text": [ "In simultaneous bilateral nerve recordings , patients with Sympathetically Maintained Pain ( SMP ) affecting one limb show similar sympathetic traffic in nerves supplying the affected and unaffected limb , also when the painful limb shows a marked regional autonomic ( vasomotor ) dysfunction . These findings argue against the notion that SMP must be mediated by a reflex change in the pattern of sympathetic discharge . In general , they underline the fact that autonomic effector disturbances may give little information about underlying nerve traffic ." ], "offsets": [ [ 0, 556 ] ] } ]	[ { "id": "DerSchmerz.80120272.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 26, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.80120272.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 45, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.80120272.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "Pain" ], "offsets": [ [ 86, 90 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120272.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "limb" ], "offsets": [ [ 113, 117 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerSchmerz.80120272.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "nerves" ], "offsets": [ [ 154, 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DerSchmerz.80120276.eng.abstr	DerSchmerz.80120276.eng.abstr	[ { "id": "DerSchmerz.80120276.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Neuropathic pain syndromes may be treated by intervention at the sympathetic nervous system . The pain in these syndromes is therefore called sympathetically maintained pain ( SMP ) . Typical disorders with a SMP component are complex regional pain syndromes ( reflex sympathetic dystrophy and causalgia ) , traumatic neuralgias and herpes zoster ." ], "offsets": [ [ 0, 361 ] ] } ]	[ { "id": "DerSchmerz.80120276.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 25, 29 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120276.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 30, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerSchmerz.80120276.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "nervous" ], "offsets": [ [ 90, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.80120276.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pain syndromes" ], "offsets": [ [ 25, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0391976" } ] }, { "id": "DerSchmerz.80120276.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "nervous system" ], "offsets": [ [ 90, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027763" } ] }, { "id": "DerSchmerz.80120276.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "sympathetic nervous system" ], "offsets": [ [ 78, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039044" } ] }, { "id": "DerSchmerz.80120276.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 111, 115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120276.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 125, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerSchmerz.80120276.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 182, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120276.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 205, 214 ] ], 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DerSchmerz.80120282.eng.abstr	DerSchmerz.80120282.eng.abstr	[ { "id": "DerSchmerz.80120282.eng.abstr-passage-0", "type": "abstract", "text": [ "The term \" sympathetically maintained pain \" ( SMP ) describes a symptom that might accompany a variety of diseases ( CRPS , ( post- ) herpetic and post-injury neuralgia ) , which might transform into sympathetically independent pain ( SIP ) after some time . Patients with SMP present a bunch of disorders of the autonomic and sensory system , but the only reliable way to diagnose a pain as SMP is a positive response to an intervention at the sympathetic nervous system . Three ways of influencing the sympathetic system are commonly used : ( a ) local anesthetic sympathetic blockade ( SB ) , ( b ) intravenous regional sympathectomy ( IVRS ) and ( c ) ganglionic local opioid application ( GLOA ) . A review of current literature shows that SB has certain advantages in diagnostic sensitivity , whereas GLOA might be slightly superior in therapy of some diseases with longstanding pain history . Obviously , the therapeutic benefit of all interventions is complete independent of the accompanying autonomic disorder and of a blockade of efferent fibers . A new heuristic model of the SMP mechanism is presented , including both experimental and clinical data . For reducing the risks of false positive or negative diagnosis of SMP and SIP , a diagnostic algorithm is proposed . This includes optimizing the technique , changes of interventional measures , and adequate monitoring both of analgesia and as well of the extend of efferent sympathetic blockade ( e.g. measurement of sympathetic reflexes ) . The treatment recommendations in patients with SMP vary in dependence of the kind of disease . In SMP , invasive measures play an important , but only limited role within the comprehensive treatment concept . As an example a three-stage , symptom-adapted treatment algorithm is demonstrated for CRPS , including also drug therapy , psychologic and physiotherapeutic approaches ." ], "offsets": [ [ 0, 1887 ] ] } ]	[ { "id": "DerSchmerz.80120282.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 38, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120282.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "symptom" ], "offsets": [ [ 65, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerSchmerz.80120282.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 107, 115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.80120282.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "post-injury" ], "offsets": [ [ 148, 159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0175677" }, { "db_name": "UMLS", "db_id": "C0021501" } ] }, { "id": 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DerSchmerz.80120323.eng.abstr	DerSchmerz.80120323.eng.abstr	[ { "id": "DerSchmerz.80120323.eng.abstr-passage-0", "type": "abstract", "text": [ "Treatment of pain is an medical operation that requires informed consent of the patient as justification . Invasive treatment of pain causes frequently civil and sometimes even criminal responsability of the physician which can be reduced by detailed information about typical risks . Information about abuse , physical and psychological dependence and consequences on the ability to operate a vehicle must be a part of a medicinal treatment . In any treatment , the patient has a right to information about serious alternativemethods . It is the responsibility of the physician to inform the patient in a personal dialogue . Information forms can support but not replace the dialogue . In case of minority of the patient or missing expression of will the physician has to inform the legal representative ( s ) or to search for the presumed will of the patient . The information about post operative treatment should take place before the operation to keep the patients consent free of influence of anasthesia or pain caused by the operation . Treatment of pain is often not vital and additional to treatment of the basic desease , so that the physician has to inform both about the treatment of pain and of basic desease . Even by final desease a renunciation of information is possible only under very restricted circumstances . Documentation has to be a part of any information to avoid lack of evidence in a trial ." ], "offsets": [ [ 0, 1419 ] ] } ]	[ { "id": "DerSchmerz.80120323.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Treatment" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120323.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 13, 17 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120323.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "operation" ], "offsets": [ [ 32, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerSchmerz.80120323.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 80, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.80120323.eng.abstr-s1-t5", "type": 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"DerSchmerz.80120323.eng.abstr-s9-t4", "arg2_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s3-r6-t1.1-t2.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t2", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s4-r1-t3.1-t1.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t3", "arg2_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s5-r1-t1.1-t2.1", "type": "treats", "arg1_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t2", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s5-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t2", "arg2_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s7-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t2", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s7-r2-t2.1-t1.1", "type": "treats", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t2", "arg2_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s7-r3-t2.1-t3.1", "type": "treats", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t2", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t3", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s7-r4-t3.1-t2.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t3", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t2", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s8-r1-t2.2-t1.1", "type": "performs", "arg1_id": "DerSchmerz.80120323.eng.abstr-s8-t2", "arg2_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s8-r2-t2.2-t5.1", "type": "performs", "arg1_id": "DerSchmerz.80120323.eng.abstr-s8-t2", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t5", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s9-r1-t3.1-t5.1", "type": "performs", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t3", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t5", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s9-r2-t3.1-t1.1", "type": "performs", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t3", "arg2_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "normalized": [] } ]
DerSchmerz.80120330.eng.abstr	DerSchmerz.80120330.eng.abstr	[ { "id": "DerSchmerz.80120330.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Former studies performed by means of supravital methylene blue ( MB ) staining could demonstrate intraepidermal free nerve fiber endings ( FNE ) . Unfortunately , these publications were only illustrated by drawings . Furthermore , the practical details of the method were only insufficiently handed down to the posteriority . Therefore , a modification of the staining procedure should be worked out for this purpose . Subsequently , the possible advantages of the method compared with common histochemical techniques should be clarified . Regarding the possible nociceptive functions of the FNE , the corresponding conclusions should be drawn from the results ." ], "offsets": [ [ 0, 678 ] ] } ]	[ { "id": "DerSchmerz.80120330.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "methylene" ], "offsets": [ [ 63, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0054666" }, { "db_name": "UMLS", "db_id": "C0284756" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 132, 137 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "methylene blue" ], "offsets": [ [ 63, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025746" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "nerve fiber" ], "offsets": [ [ 132, 143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027749" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "publications" ], "offsets": [ [ 184, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034036" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "method" ], "offsets": [ [ 276, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "procedure" ], "offsets": [ [ 385, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "method" ], "offsets": [ [ 481, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 523, 533 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "functions" ], "offsets": [ [ 591, 600 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031843" } ] } ]	[]	[]	[ { "id": "DerSchmerz.80120330.eng.abstr-s1-r1-t1.1-t1.2", "type": "interacts_with", "arg1_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r2-t1.1-t4.1", "type": "disrupts", "arg1_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.80120330.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r3-t1.1-t2.1", "type": "affects", "arg1_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r4-t2.1-t1.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.80120330.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r5-t4.1-t1.1", "type": "affects", "arg1_id": "DerSchmerz.80120330.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r6-t1.1-t2.1", "type": "treats", "arg1_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r7-t1.1-t2.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r8-t4.1-t2.1", "type": "affects", "arg1_id": "DerSchmerz.80120330.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r9-t4.1-t1.1", "type": "produces", "arg1_id": "DerSchmerz.80120330.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r10-t4.1-t1.2", "type": "produces", "arg1_id": "DerSchmerz.80120330.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t1", "normalized": [] } ]
DerSchmerz.80120336.eng.abstr	DerSchmerz.80120336.eng.abstr	[ { "id": "DerSchmerz.80120336.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Pain in childhood still seems to be a major problem . In this study we investigated parents ' opinion about the frequency of pain in their children and the efficacy of pain treatment ." ], "offsets": [ [ 0, 199 ] ] } ]	[ { "id": "DerSchmerz.80120336.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Pain" ], "offsets": [ [ 15, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "parents" ], "offsets": [ [ 99, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030551" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "frequency" ], "offsets": [ [ 127, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376249" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 140, 144 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "children" ], "offsets": [ [ 154, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008059" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 183, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 188, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]	[]	[]	[ { "id": "DerSchmerz.80120336.eng.abstr-s2-r1-t6.1-t2.1", "type": "treats", "arg1_id": "DerSchmerz.80120336.eng.abstr-s2-t6", "arg2_id": "DerSchmerz.80120336.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-r2-t1.1-t6.1", "type": "performs", "arg1_id": "DerSchmerz.80120336.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.80120336.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-r3-t4.1-t1.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120336.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.80120336.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-r4-t1.1-t4.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120336.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.80120336.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-r5-t4.1-t6.1", "type": "performs", "arg1_id": "DerSchmerz.80120336.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.80120336.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-r6-t6.1-t5.1", "type": "treats", "arg1_id": "DerSchmerz.80120336.eng.abstr-s2-t6", "arg2_id": "DerSchmerz.80120336.eng.abstr-s2-t5", "normalized": [] } ]
DerSchmerz.80120342.eng.abstr	DerSchmerz.80120342.eng.abstr	[ { "id": "DerSchmerz.80120342.eng.abstr-passage-0", "type": "abstract", "text": [ "Some recent studies report on slightly increased serum levels of anticardiolipin IgG antibodies in patients with migraine with and without aura ." ], "offsets": [ [ 0, 145 ] ] } ]	[ { "id": "DerSchmerz.80120342.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "IgG" ], "offsets": [ [ 81, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020852" } ] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "antibodies" ], "offsets": [ [ 85, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 99, 107 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 113, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "aura" ], "offsets": [ [ 139, 143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0236018" } ] } ]	[]	[]	[ { "id": "DerSchmerz.80120342.eng.abstr-s1-r1-t4.1-t3.1", "type": "occurs_in", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r2-t1.1-t4.1", "type": "indicates", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r3-t4.1-t2.1", "type": "produces", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t2", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r4-t1.1-t2.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t2", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r5-t2.1-t4.1", "type": "indicates", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t2", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r6-t5.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t5", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r7-t4.1-t1.1", "type": "produces", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r8-t4.1-t5.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t5", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r9-t1.1-t4.1", "type": "affects", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r10-t2.1-t1.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t2", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t1", "normalized": [] } ]
DerSchmerz.80120383.eng.abstr	DerSchmerz.80120383.eng.abstr	[ { "id": "DerSchmerz.80120383.eng.abstr-passage-0", "type": "abstract", "text": [ "The antipyretic analgesics still comprise the most widely used group of analgesic compounds . Until twenty years ago , aspirin , phenazone derivatives and acetaminophen had been used as standard remedies for intercurrent harmless pain conditions in connection with infections , trauma , small surgeries , but also for tension headache and other painful conditions . During the last decades , this group has been supplemented by a variety of 2-arylpropionic acids being primarily developed for the treatment of rheumatic pain and inflammation . Some of them ( e.g. ibuprofen , ketoprofen and naproxen ) have been given over-the-counter status in some countries because of their relative safety at low doses . Nevertheless , pharmacodynamic and pharmacokinetic differences among the various substances of this group make them suitable to a different degree for the treatment of pain conditions ." ], "offsets": [ [ 0, 893 ] ] } ]	[ { "id": "DerSchmerz.80120383.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "antipyretic" ], "offsets": [ [ 4, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003419" } ] }, { "id": "DerSchmerz.80120383.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "analgesics" ], "offsets": [ [ 16, 26 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.80120383.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "analgesic" ], "offsets": [ [ 72, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.80120383.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "aspirin" ], "offsets": [ [ 119, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004057" } ] }, { "id": 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[] }, { "id": "DerSchmerz.80120383.eng.abstr-s4-r6-t1.1-t2.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s5-r1-t2.1-t1.1", "type": "treats", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t1", "normalized": [] } ]
DerSchmerz.80120389.eng.abstr	DerSchmerz.80120389.eng.abstr	[ { "id": "DerSchmerz.80120389.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : Regarding the coherence of sleeping behavior and the occurrence of migraine attacks , we conducted a study based on migraine and sleeping diaries ." ], "offsets": [ [ 0, 157 ] ] } ]	[ { "id": "DerSchmerz.80120389.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "behavior" ], "offsets": [ [ 46, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004927" } ] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "occurrence" ], "offsets": [ [ 63, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243132" } ] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 77, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 126, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "diaries" ], "offsets": [ [ 148, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376660" } ] } ]	[]	[]	[ { "id": "DerSchmerz.80120389.eng.abstr-s1-r1-t4.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120389.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120389.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-r2-t2.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120389.eng.abstr-s1-t2", "arg2_id": "DerSchmerz.80120389.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-r3-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120389.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.80120389.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-r4-t1.1-t2.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120389.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.80120389.eng.abstr-s1-t2", "normalized": [] } ]
DerSchmerz.80120400.eng.abstr	DerSchmerz.80120400.eng.abstr	[ { "id": "DerSchmerz.80120400.eng.abstr-passage-0", "type": "abstract", "text": [ "Neck pain after whiplash injury of the cervical spine often induces typical changes in head motion patterns ( amplitude , velocity ) . These changes of kinematics may help to recognize malingerers . We investigated the hypothesis that malingerers are not able to reproduce their simulated head movement disturbances three times . The kinematics of head movements of 23 patients with neck pain after whiplash injury and of 22 healthy subjects trying to act as malingerers were compared . The healthies were informed about the symptomatology of whiplash injury and were asked to simulate painful head movements . Two different kinds of head movements were registered and analyzed by Cervicomotography : ( 1 ) the slow free axial head rotation ( yaw ) and ( 2 ) the axial head rotation ( yaw ) tracking a moving visual target . Each experimental condition was presented three times , expecting the malingerers not to be able to produce as well as to reproduce the same head movement disturbances again and again . In patients , as a consequence of their distinct pain patterns , we expected less variance between the test repetitions . The statistical analysis showed significant differences of the calculated kinematic parameters between both groups and the inability of healthy subjects to simulate and to reproduce convincingly distinct pain patterns ." ], "offsets": [ [ 0, 1352 ] ] } ]	[ { "id": "DerSchmerz.80120400.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Neck" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027530" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 5, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "whiplash" ], "offsets": [ [ 16, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "injury" ], "offsets": [ [ 25, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0175677" }, { "db_name": "UMLS", "db_id": "C0021501" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "spine" ], "offsets": [ [ 48, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037949" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "head" ], "offsets": [ [ 87, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "motion" ], "offsets": [ [ 92, 98 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026597" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "Neck pain" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007859" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "whiplash injury" ], "offsets": [ [ 16, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "kinematics" ], "offsets": [ [ 152, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600169" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "simulated" ], "offsets": [ [ 279, 288 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0284447" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "head" ], "offsets": [ [ 289, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "movement" ], "offsets": [ [ 294, 302 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026649" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "times" ], "offsets": [ [ 322, 327 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "head movement" ], "offsets": [ [ 289, 302 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376591" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "kinematics" ], "offsets": [ [ 334, 344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600169" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "head" ], "offsets": [ [ 348, 352 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "movements" ], "offsets": [ [ 353, 362 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026649" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 369, 377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "neck" ], "offsets": [ [ 383, 387 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027530" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 388, 392 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "whiplash" ], "offsets": [ [ 399, 407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "injury" ], "offsets": [ [ 408, 414 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0175677" }, { "db_name": "UMLS", "db_id": "C0021501" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "head movements" ], "offsets": [ [ 348, 362 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376591" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "neck pain" ], "offsets": [ [ 383, 392 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007859" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t11", "type": "umlsterm", "text": [ "whiplash injury" ], "offsets": [ [ 399, 414 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "whiplash" ], "offsets": [ [ 543, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "injury" ], "offsets": [ [ 552, 558 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0175677" }, { "db_name": "UMLS", "db_id": "C0021501" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "head" ], "offsets": [ [ 594, 598 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "movements" ], "offsets": [ [ 599, 608 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026649" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "whiplash injury" ], "offsets": [ 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DerSchmerz.90130003.eng.abstr	DerSchmerz.90130003.eng.abstr	[ { "id": "DerSchmerz.90130003.eng.abstr-passage-0", "type": "abstract", "text": [ "Mechanisms in the lesioned muscle : The peripheral mechanism underlying the tenderness and pain during movement of a damaged muscle is the sensitization of muscle nociceptors . Ongoing activity of nociceptors causes spontaneous pain in addition to tenderness . Muscle pain ( particularly that originating in myofascial trigger points ) is often mislocalized because it is referred to other deep somatic tissues . 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DerSchmerz.90130019.eng.abstr	DerSchmerz.90130019.eng.abstr	[ { "id": "DerSchmerz.90130019.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Aim of the present prospective longitudinal study was the statistical foundation and thus further replication of recent findings of Hasenbring [ 13 ] , who postulated a significant importance of specific , within the psychological pain research long neglected pain coping strategies as risk factors concerning pain chronification : appeals to \" stick it out \" on the cognitive level and endurance strategies on the behavioural level ." ], "offsets": [ [ 0, 447 ] ] } ]	[ { "id": "DerSchmerz.90130019.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "foundation" ], "offsets": [ [ 83, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016617" } ] }, { "id": "DerSchmerz.90130019.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 133, 141 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerSchmerz.90130019.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "Hasenbring" ], "offsets": [ [ 145, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0605770" } ] }, { "id": "DerSchmerz.90130019.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Hasenbring" ], "offsets": [ [ 145, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006222" } ] }, { "id": "DerSchmerz.90130019.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 244, 248 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130019.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "research" ], "offsets": [ [ 249, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "DerSchmerz.90130019.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 273, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130019.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "risk" ], 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DerSchmerz.90130031.eng.abstr	DerSchmerz.90130031.eng.abstr	[ { "id": "DerSchmerz.90130031.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : In a cognitive perspective , chronic pain comprises at least three dimensions : First it is possible to study the relevance of pain related attitudes , beliefs and coping cognitions for the chronification of pain . Second psychological processes of learning and memory processes can be analysed . Third we can investigate uncontrolled cognitions in chronical pain patients ." ], "offsets": [ [ 0, 387 ] ] } ]	[ { "id": "DerSchmerz.90130031.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 50, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 140, 144 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "attitudes" ], "offsets": [ [ 153, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004271" } ] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "beliefs" ], "offsets": [ [ 165, 172 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004951" } ] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "cognitions" ], "offsets": [ [ 184, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009240" } ] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 221, 225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130031.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "memory" ], "offsets": [ [ 275, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025260" } ] }, { "id": "DerSchmerz.90130031.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "cognitions" ], "offsets": [ [ 348, 358 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009240" } ] }, { "id": "DerSchmerz.90130031.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 372, 376 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130031.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 377, 385 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] } ]	[]	[]	[ { "id": "DerSchmerz.90130031.eng.abstr-s1-r1-t6.1-t3.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.90130031.eng.abstr-s1-t6", "arg2_id": "DerSchmerz.90130031.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-r2-t2.1-t4.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.90130031.eng.abstr-s3-t2", "arg2_id": "DerSchmerz.90130031.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-r3-t4.1-t3.1", "type": "result_of", "arg1_id": "DerSchmerz.90130031.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.90130031.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-r4-t1.1-t3.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.90130031.eng.abstr-s3-t1", "arg2_id": "DerSchmerz.90130031.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-r5-t6.1-t4.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.90130031.eng.abstr-s1-t6", "arg2_id": "DerSchmerz.90130031.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-r6-t2.1-t3.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.90130031.eng.abstr-s3-t2", "arg2_id": "DerSchmerz.90130031.eng.abstr-s3-t3", "normalized": [] }, { "id": "DerSchmerz.90130031.eng.abstr-s1-r7-t1.1-t4.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.90130031.eng.abstr-s3-t1", "arg2_id": "DerSchmerz.90130031.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.90130031.eng.abstr-s3-r1-t2.1-t1.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.90130031.eng.abstr-s3-t2", "arg2_id": "DerSchmerz.90130031.eng.abstr-s3-t1", "normalized": [] } ]
DerSchmerz.90130043.eng.abstr	DerSchmerz.90130043.eng.abstr	[ { "id": "DerSchmerz.90130043.eng.abstr-passage-0", "type": "abstract", "text": [ "The prescription of strong opioids underlies a special legislation . The attitude of the pharmacists towards the long-term treatment with these analgesics and their opinion about the legislation is unknown in Germany and other European countries ." ], "offsets": [ [ 0, 247 ] ] } ]	[ { "id": "DerSchmerz.90130043.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "prescription" ], "offsets": [ [ 4, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033080" } ] }, { "id": "DerSchmerz.90130043.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "opioids" ], "offsets": [ [ 27, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.90130043.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "legislation" ], "offsets": [ [ 55, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023252" } ] }, { "id": "DerSchmerz.90130043.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "prescription of" ], "offsets": [ [ 4, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033080" } ] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "attitude" ], "offsets": [ [ 73, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004271" } ] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pharmacists" ], "offsets": [ [ 89, 100 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031323" } ] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 123, 132 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "analgesics" ], "offsets": [ [ 144, 154 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "legislation" ], "offsets": [ [ 183, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023252" } ] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 209, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "long-term treatment" ], "offsets": [ [ 113, 132 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023977" } ] } ]	[]	[]	[ { "id": "DerSchmerz.90130043.eng.abstr-s1-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s1-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t2", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-r1-t3.2-t1.1", "type": "result_of", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-r2-t3.1-t1.1", "type": "affects", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-r3-t3.1-t7.1", "type": "isa", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-r4-t2.1-t5.1", "type": "uses", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t2", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-r5-t2.1-t7.1", "type": "performs", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t2", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t7", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-r6-t5.1-t2.1", "type": "affects", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t5", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-r7-t6.1-t1.1", "type": "result_of", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t6", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-r8-t7.1-t1.1", "type": "affects", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t7", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-r9-t3.1-t1.1", "type": "result_of", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.90130043.eng.abstr-s2-r10-t2.1-t3.1", "type": "performs", "arg1_id": "DerSchmerz.90130043.eng.abstr-s2-t2", "arg2_id": "DerSchmerz.90130043.eng.abstr-s2-t3", "normalized": [] } ]
DerSchmerz.90130048.eng.abstr	DerSchmerz.90130048.eng.abstr	[ { "id": "DerSchmerz.90130048.eng.abstr-passage-0", "type": "abstract", "text": [ "Case : On the basis of a case report the often difficult classification of migraine with aura and exclusion of symptomatic origin is discussed . In spring 1996 a 34-years old patient started to suffer from attacks of a migraine like headache with focal aura several times a week ." ], "offsets": [ [ 0, 280 ] ] } ]	[ { "id": "DerSchmerz.90130048.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "classification" ], "offsets": [ [ 57, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" }, { "db_name": "UMLS", "db_id": "C0008903" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 75, 83 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "aura" ], "offsets": [ [ 89, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0236018" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "origin" ], "offsets": [ [ 123, 129 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079946" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "case report" ], "offsets": [ [ 25, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007320" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "migraine with aura" ], "offsets": [ [ 75, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0154723" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "old" ], "offsets": [ [ 171, 174 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 175, 182 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 219, 227 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "headache" ], "offsets": [ [ 233, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "aura" ], "offsets": [ [ 253, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0236018" } ] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "times" ], "offsets": [ [ 266, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] } ]	[]	[]	[ { "id": "DerSchmerz.90130048.eng.abstr-s1-r1-t1.1-t3.1", "type": "isa", "arg1_id": "DerSchmerz.90130048.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s1-r2-t1.2-t5.1", "type": "isa", "arg1_id": "DerSchmerz.90130048.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s1-r3-t3.1-t1.2", "type": "associated_with", "arg1_id": "DerSchmerz.90130048.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.90130048.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s1-r4-t1.1-t5.1", "type": "isa", "arg1_id": "DerSchmerz.90130048.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s1-r5-t1.2-t3.1", "type": "isa", "arg1_id": "DerSchmerz.90130048.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s1-r6-t1.2-t3.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130048.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-r1-t3.1-t1.1", "type": "affects", "arg1_id": "DerSchmerz.90130048.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-r2-t5.1-t3.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130048.eng.abstr-s2-t5", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-r3-t3.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130048.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-r4-t3.1-t1.1", "type": "occurs_in", "arg1_id": "DerSchmerz.90130048.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-r5-t4.1-t3.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130048.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.90130048.eng.abstr-s2-r6-t3.1-t5.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130048.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.90130048.eng.abstr-s2-t5", "normalized": [] } ]
DerSchmerz.90130087.eng.abstr	DerSchmerz.90130087.eng.abstr	[ { "id": "DerSchmerz.90130087.eng.abstr-passage-0", "type": "abstract", "text": [ "At the end of the thirties , the first papers from Wolff and Graham represented the beginning of modern migraine research . Since that time advance is important . Several medical disciplines and special fields in research such as neurology , clinical and experimental neurophysiology , neuroradiology , psychiatry , medical psychology , psychosomatics , biochemistry , genetics , pharmacology , epidemiology contributed to the new cognitions . Further exploration of genetics and of the interictal neuronal and neurovascular dysfunctions are the key for both understanding of migraine as disease and pathogenesis of migraine attacks . All together migraine may be defined as a specific dysfunction in neuronal information processing and neurovascular reagibility corresponding with imbalance of certain neurotransmitters ( NA , 5-HT ) and leading to ictal reactions of brain areas and intracranial vessels in critical phases of hyperreagibility and hyperactivity . In the pathogenetical and pathophysiological processings both genetic and acquired mechanisms might be involved . Aura symptoms result from abnormal vasoconstriction with oligemia or ischemia of the tissue as Wolff supposed it . The headache phase follows with delay because the pain inducing neurogenic inflammation in the vessel walls need more time for clinical manifestation than the oligemic resp. ischemic brain symptoms ." ], "offsets": [ [ 0, 1393 ] ] } ]	[ { "id": "DerSchmerz.90130087.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "papers" ], "offsets": [ [ 39, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030351" } ] }, { "id": "DerSchmerz.90130087.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 104, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.90130087.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "research" ], "offsets": [ [ 113, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "DerSchmerz.90130087.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 135, 139 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": 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DerSchmerz.90130097.eng.abstr	DerSchmerz.90130097.eng.abstr	[ { "id": "DerSchmerz.90130097.eng.abstr-passage-0", "type": "abstract", "text": [ "Complementary medicine is not a therapy without side effects . Undergoing acupuncture can result in hazardous complications . Therefore patients should be advised of adverse events associated with acupuncture . A consent form for acupuncture is presented . Only physicians with good anatomical and clinical skills should use acupuncture ." ], "offsets": [ [ 0, 338 ] ] } ]	[ { "id": "DerSchmerz.90130097.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "medicine" ], "offsets": [ [ 14, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025118" }, { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 32, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "Complementary medicine" ], "offsets": [ [ 0, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002346" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "side effects" ], "offsets": [ [ 48, 60 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001688" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 74, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 110, 123 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 136, 144 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 197, 208 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 230, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "consent form" ], "offsets": [ [ 213, 225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009797" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "physicians" ], "offsets": [ [ 262, 272 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "anatomical" ], "offsets": [ [ 283, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220784" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "acupuncture" ], "offsets": [ [ 325, 336 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "DerSchmerz.90130097.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "clinical skills" ], "offsets": [ [ 298, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008973" } ] } ]	[]	[]	[ { "id": "DerSchmerz.90130097.eng.abstr-s1-r1-t1.2-t4.1", "type": "treats", "arg1_id": "DerSchmerz.90130097.eng.abstr-s1-t1", "arg2_id": 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"DerSchmerz.90130097.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s1-r7-t2.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t4", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s1-r8-t4.1-t1.1", "type": "issue_in", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t4", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s1-r9-t2.2-t2.1", "type": "issue_in", "arg1_id": "DerSchmerz.90130097.eng.abstr-s1-t2", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s1-r10-t1.2-t1.1", "type": "issue_in", "arg1_id": "DerSchmerz.90130097.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s1-r11-t2.1-t1.2", "type": "uses", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.90130097.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s1-r12-t4.1-t2.1", "type": "issue_in", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t4", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s1-r13-t2.1-t1.1", "type": "issue_in", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s2-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s2-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s3-r1-t1.1-t2.1", "type": "performs", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s3-r2-t2.1-t1.1", "type": "affects", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s4-r1-t1.1-t2.1", "type": "uses", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s5-r1-t4.1-t2.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t4", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.90130097.eng.abstr-s5-r2-t1.1-t2.1", "type": "performs", "arg1_id": "DerSchmerz.90130097.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.90130097.eng.abstr-s5-t2", "normalized": [] } ]
DerSchmerz.90130113.eng.abstr	DerSchmerz.90130113.eng.abstr	[ { "id": "DerSchmerz.90130113.eng.abstr-passage-0", "type": "abstract", "text": [ "Objectives : We performed 52 peripheral nerve stimulation procedures since 1991. In addition to 48 patients with CRPS II , 4 patients with phantom-limb pain were treated . Incomplete or complete lesion of the stimulated peripheral nerves was determined in all patients . Surgically treatment failed in all cases . All patients had been given extensive conservative pain therapy ." ], "offsets": [ [ 0, 379 ] ] } ]	[ { "id": "DerSchmerz.90130113.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objectives" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 40, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 58, 68 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 99, 107 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 125, 133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "phantom-limb" ], "offsets": [ [ 139, 151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 152, 156 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "peripheral nerve" ], "offsets": [ [ 29, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031119" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "nerves" ], "offsets": [ [ 231, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 260, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "peripheral nerves" ], "offsets": [ [ 220, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031119" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 282, 291 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "Surgically treatment" ], "offsets": [ [ 271, 291 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "All" ], "offsets": [ [ 314, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023449" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 318, 326 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 365, 369 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 370, 377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "pain therapy" ], "offsets": [ [ 365, 377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002766" } ] } ]	[]	[]	[ { "id": "DerSchmerz.90130113.eng.abstr-s1-r1-t6.1-t2.1", "type": "result_of", "arg1_id": "DerSchmerz.90130113.eng.abstr-s1-t6", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r2-t3.1-t2.1", "type": "measurement_of", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t3", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r3-t8.1-t2.1", "type": "location_of", "arg1_id": "DerSchmerz.90130113.eng.abstr-s1-t8", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r4-t7.1-t2.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.90130113.eng.abstr-s1-t7", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r5-t5.1-t2.1", "type": "uses", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t5", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r6-t8.1-t6.1", "type": "adjacent_to", "arg1_id": "DerSchmerz.90130113.eng.abstr-s1-t8", "arg2_id": "DerSchmerz.90130113.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r7-t2.1-t6.1", "type": "measurement_of", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.90130113.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r8-t2.1-t3.2", "type": "uses", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.90130113.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r9-t5.1-t3.2", "type": "uses", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t5", "arg2_id": "DerSchmerz.90130113.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r10-t6.1-t8.1", "type": "adjacent_to", "arg1_id": "DerSchmerz.90130113.eng.abstr-s1-t6", "arg2_id": "DerSchmerz.90130113.eng.abstr-s1-t8", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r11-t5.1-t1.1", "type": "uses", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t5", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r12-t2.1-t1.1", "type": "uses", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s1-r13-t3.1-t6.1", "type": "measurement_of", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t3", "arg2_id": "DerSchmerz.90130113.eng.abstr-s1-t6", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s2-r1-t3.1-t1.1", "type": "location_of", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t3", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-r1-t4.1-t3.1", "type": "treats", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t4", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t3", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-r2-t4.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t4", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-r3-t2.1-t4.1", "type": "performs", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t4", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-r4-t3.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t3", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t1", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-r5-t1.1-t2.1", "type": "occurs_in", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-r6-t4.1-t2.1", "type": "affects", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t4", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t2", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-r7-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t4", "normalized": [] }, { "id": "DerSchmerz.90130113.eng.abstr-s4-r8-t1.1-t3.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130113.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.90130113.eng.abstr-s4-t3", "normalized": [] } ]
DerSchmerz.90130127.eng.abstr	DerSchmerz.90130127.eng.abstr	[ { "id": "DerSchmerz.90130127.eng.abstr-passage-0", "type": "abstract", "text": [ "Objective : The objective of this survey was to investigate the current status of the epidural and intrathecal management in patients with chronic cancer and non-cancer pain in Germany and Austria . Methods : In June 1997 a questionnaire was sent to 598 German and Austrian anaesthesiologists specialized in pain therapy . Questions concerning the use of medicaments for epidural and intrathecal treatment of chronic pain were asked . Results : The response rate was 23% . The data show that 78% of the anaesthesiologists use epidural or intrathecal analgesia in the therapy of chronic pain . Local anaesthetics are used by 85% of these anaesthesiologists , followed by morphine ( 72% ) , clonidine ( 48% ) , buprenorphine ( 34% ) , baclofen ( 20% ) , fentanyl ( 13% ) and sufentanil ( 10% ) . For most of the treatments local anaesthetics are used , again followed by opioids und clonidine . In the 137 answering pain clinics 79.821 epidural and intrathecal analgetic treatments are performed per year . Discussion : Epidural and intrathecal pain therapy is frequently used in Germany and Austria , either as a complementary or alternative treatment to systemic pain therapy . Local anaesthetics followed by opioids are the most commonly used medicaments for this treatment . For some of the applied substances neurotoxicological data are lacking . The use of these substances has to be considered very carefully ." ], "offsets": [ [ 0, 1415 ] ] } ]	[ { "id": "DerSchmerz.90130127.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objective" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerSchmerz.90130127.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "objective" ], "offsets": [ [ 16, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerSchmerz.90130127.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "survey" ], "offsets": [ [ 34, 40 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038951" } ] }, { "id": "DerSchmerz.90130127.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 125, 133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130127.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "cancer" ], "offsets": [ [ 147, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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DerSchmerz.90130133.eng.abstr	DerSchmerz.90130133.eng.abstr	[ { "id": "DerSchmerz.90130133.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Drug therapy plays often an important role in the treatment of chronic pain . Former studies and also experiences of clinical practice have given evidence , that insufficient patient compliance is a widespread event . Therefore drug screening becomes a significant tool for quality assurance . In the following the methodical and practical aspects of drug screening are described and recommendations for its use in clinical practice are suggested ." ], "offsets": [ [ 0, 463 ] ] } ]	[ { "id": "DerSchmerz.90130133.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Drug" ], "offsets": [ [ 15, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 20, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 53, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 65, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 86, 90 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "Drug therapy" ], "offsets": [ [ 15, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" }, { "db_name": "UMLS", "db_id": "C0013217" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 190, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "compliance" ], "offsets": [ [ 198, 208 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030680" }, { "db_name": "UMLS", "db_id": "C0009563" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "patient compliance" ], "offsets": [ [ 190, 208 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030680" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 243, 247 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "screening" ], "offsets": [ [ 248, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220908" }, { "db_name": "UMLS", "db_id": "C0220909" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "drug screening" ], "offsets": [ [ 243, 257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013206" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 366, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "screening" ], "offsets": [ [ 371, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220908" }, { "db_name": "UMLS", "db_id": "C0220909" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "recommendations" ], "offsets": [ [ 399, 414 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034866" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 423, 426 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "DerSchmerz.90130133.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "drug screening" ], "offsets": [ [ 366, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013206" } ] } ]	[]	[]	[ { "id": "DerSchmerz.90130133.eng.abstr-s1-r1-t1.1-t4.1", "type": "treats", "arg1_id": "DerSchmerz.90130133.eng.abstr-s4-t1", "arg2_id": "DerSchmerz.90130133.eng.abstr-s4-t4", "normalized": [] }, { "id": "DerSchmerz.90130133.eng.abstr-s2-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130133.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.90130133.eng.abstr-s4-t1", "normalized": [] }, { 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"DerSchmerz.90130133.eng.abstr-s4-r7-t2.1-t3.1", "type": "isa", "arg1_id": "DerSchmerz.90130133.eng.abstr-s4-t2", "arg2_id": "DerSchmerz.90130133.eng.abstr-s4-t3", "normalized": [] } ]
DerSchmerz.90130183.eng.abstr	DerSchmerz.90130183.eng.abstr	[ { "id": "DerSchmerz.90130183.eng.abstr-passage-0", "type": "abstract", "text": [ "In patients with renal or hepatic failure , the pharmacokinetics of opioids may be affected in several ways , leading to the necessity to correct the dose . The liver is the major site for biotransformation of most opioids . The major metabolic pathway is oxidation . Exceptions to this are morphine and buprenorphine , which undergo primarily glucuronidation , and remifentanil which is cleared by esther hydrolysis . The hydrophilic metabolites are predominantly excreted by the kidneys and may accumulate in patients with renal insufficiency . Some metabolites such as morphine-6-glucuronide ( M6G) or normeperidine are active opioid agonists . With high concentrations they may cause narcotic effects or respiratory depression . In addition , special risks are known for normepridine that has been shown to exert neurotoxic effects with the risk of seizures . Few cases of respiratory depression following the administration of codeine , dihydrocodeine and tramdol have been reported . The elimination half-life of these drugs was prolonged . Lastly , the disposition of methadone , buprenorphine , fentanyl , sufentanyl and remifentanil appears to be unaffected in renal failure ." ], "offsets": [ [ 0, 1185 ] ] } ]	[ { "id": "DerSchmerz.90130183.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 3, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pharmacokinetics" ], "offsets": [ [ 48, 64 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031327" }, { "db_name": "UMLS", "db_id": "C0031328" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "opioids" ], "offsets": [ [ 68, 75 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "hepatic failure" ], "offsets": [ [ 26, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085605" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "liver" ], "offsets": [ [ 161, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0345904" }, { "db_name": "UMLS", "db_id": "C0023884" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "biotransformation" ], "offsets": [ [ 189, 206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220798" }, { "db_name": "UMLS", "db_id": "C0005576" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "opioids" ], "offsets": [ [ 215, 222 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "morphine" ], "offsets": [ [ 291, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026549" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "buprenorphine" ], "offsets": [ [ 304, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006405" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "remifentanil" ], "offsets": [ [ 366, 378 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0246631" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "hydrolysis" ], "offsets": [ [ 406, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020291" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "kidneys" ], "offsets": [ [ 481, 488 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022646" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 511, 519 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "renal insufficiency" ], "offsets": [ [ 525, 544 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035078" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "morphine-6-glucuronide" ], "offsets": [ [ 572, 594 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0066816" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "normeperidine" ], "offsets": [ [ 605, 618 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0069006" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "normeperidine" ], "offsets": [ [ 605, 618 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025376" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "opioid" ], "offsets": [ [ 630, 636 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "agonists" ], "offsets": [ [ 637, 645 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243192" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "concentrations" ], 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DerSchmerz.90130196.eng.abstr	DerSchmerz.90130196.eng.abstr	[ { "id": "DerSchmerz.90130196.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Migraine is a common neurological disorder ( 16% women , 6% men ) associated with high direct and indirect costs . We evaluated the diagnostic and paramedical therapeutic measures by estimating the expenditure per patient and the effect of treatment ." ], "offsets": [ [ 0, 264 ] ] } ]	[ { "id": "DerSchmerz.90130196.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Migraine" ], "offsets": [ [ 13, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.90130196.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 47, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.90130196.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 62, 67 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "DerSchmerz.90130196.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "men" ], "offsets": [ [ 73, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" }, { "db_name": "UMLS", "db_id": "C0024554" } ] }, { "id": "DerSchmerz.90130196.eng.abstr-s1-t5", "type": 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DerSchmerz.90130201.eng.abstr	DerSchmerz.90130201.eng.abstr	[ { "id": "DerSchmerz.90130201.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Coenesthesias can be defined as disorders of body perception or body hallucinations , projected in different parts of the body . Patients complain of intractable pain or dysesthesia . These symptoms are reported even from organs where we usually have no perception . Coenesthesia must be regarded as a symptom that can be observed in various psychiatric diseases , e.g. , schizophrenia . However , in rare cases coenesthesias can be documented in neurological diseases , e.g. , intracranial tumors or infections . Therefore , accurate assessment of possible differential diagnoses is important . In late stages , coenesthesias can easily be recognized because of their \" bizarre \" character . In early stages , however , patients often complain of intractable , unlocalizable burning pain . They frequently undergo operations because of their great suffering . The drug treatment of first choice is neuroleptics , but the results are unpredictable ." ], "offsets": [ [ 0, 962 ] ] } ]	[ { "id": "DerSchmerz.90130201.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 45, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "perception" ], "offsets": [ [ 63, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030971" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "hallucinations" ], "offsets": [ [ 82, 96 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018524" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 142, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 175, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "dysesthesia" ], "offsets": [ [ 183, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0392699" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "intractable pain" ], "offsets": [ [ 163, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030200" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 203, 211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "perception" ], "offsets": [ [ 267, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030971" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "symptom" ], "offsets": [ [ 315, 322 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 367, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "schizophrenia" ], "offsets": [ [ 385, 398 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036341" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 473, 481 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 504, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 514, 524 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "neurological diseases" ], "offsets": [ [ 460, 481 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027765" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "intracranial tumors" ], "offsets": [ [ 491, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006118" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 548, 558 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "differential diagnoses" ], "offsets": [ [ 571, 593 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011906" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "stages" ], "offsets": [ [ 617, 623 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027646" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "character" ], "offsets": [ [ 694, 703 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007952" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "stages" ], "offsets": [ [ 715, 721 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027646" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 734, 742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "burning" ], "offsets": [ [ 789, 796 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006434" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 797, 801 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "burning pain" ], "offsets": [ [ 789, 801 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0234230" } ] }, { "id": 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DerSchmerz.00140351.eng.abstr

[ { "id": "DerSchmerz.00140351.eng.abstr-passage-0", "type": "abstract", "text": [ "Background . Headaches are one of the most common health problems of children and adolescents , afflicting between 50-90% of the pediatric population in some form sometimes during their first two decades of life . Due to changing prevalence rates , more or less complex classification systems , inconsistent therapy responses with great inter- and intraindividual variabilities and high placebo response rates , pediatric headache syndromes are frequently thought to be too difficult for the outpatient evaluation and treatment in clinical practice ." ], "offsets": [ [ 0, 550 ] ] } ]

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[]

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"occurs_in", "arg1_id": "DerSchmerz.00140351.eng.abstr-s3-t11", "arg2_id": "DerSchmerz.00140351.eng.abstr-s3-t7", "normalized": [] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-r29-t2.2-t11.1", "type": "treats", "arg1_id": "DerSchmerz.00140351.eng.abstr-s3-t2", "arg2_id": "DerSchmerz.00140351.eng.abstr-s3-t11", "normalized": [] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-r30-t11.1-t9.1", "type": "associated_with", "arg1_id": "DerSchmerz.00140351.eng.abstr-s3-t11", "arg2_id": "DerSchmerz.00140351.eng.abstr-s3-t9", "normalized": [] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-r31-t8.1-t1.1", "type": "measures", "arg1_id": "DerSchmerz.00140351.eng.abstr-s3-t8", "arg2_id": "DerSchmerz.00140351.eng.abstr-s3-t1", "normalized": [] }, { "id": "DerSchmerz.00140351.eng.abstr-s3-r32-t11.1-t8.1", "type": "associated_with", "arg1_id": "DerSchmerz.00140351.eng.abstr-s3-t11", "arg2_id": "DerSchmerz.00140351.eng.abstr-s3-t8", "normalized": [] } ]

DerSchmerz.60100001.eng.abstr

[ { "id": "DerSchmerz.60100001.eng.abstr-passage-0", "type": "abstract", "text": [ "Treatment of acute pain in children is a very important part of every doctor's work , and requires well-founded knowledge of this particular age group . Even in preterm infants pain apperception is fully developed , so that adequate analgesia is necessary . During infancy and childhood the individual developmental stage must be taken into account ; the ability to cope with pain often differs distinctly from that in adults . At the starting of an analgesic regimen nonsteroidal analgesics are sufficient in most cases . If pain is severe iv morphine should be used much more often in children , because it is very effective and side effects can be avoided . In contrast to chronic pain management , pain-dependent analgesic management can be considered as beneficial . Good knowledge of a small number of drugs with their pharmacological profile is sufficient for effective analgesic results even in severe pain states in children . Behavioural medicine should be integrated into paediatric pain management as soon as possible . An early start of pain reduction and prophylaxis is the best basis for development in the direction of competent pain coping behaviour in adult life ." ], "offsets": [ [ 0, 1182 ] ] } ]

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[]

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DerSchmerz.60100014.eng.abstr

[ { "id": "DerSchmerz.60100014.eng.abstr-passage-0", "type": "abstract", "text": [ "The interactions of 2-adrenoceptor agonists with anaesthetics , analgesics and local anaesthetics are not only of practical importance in many areas of anaesthesia and pain therapy , but also of significant theoretical interest . Laboratory investigations and animal research allow us to study the pharmacological mechanisms of these drug interactions by using the tools of molecular biology . This may lead to the establishment of a scientific basis allowing the definition of rational drug therapies . In the first part of this overview , recent data on local anaesthetic effects of 2-adrenoceptor agonists on peripheral nerve conduction and their interaction with local anaesthetics are presented . Some important experimental work focusing on additive and synergistic spinal interactions of 2-adrenoceptor agonists with opioids and some other agents are then discussed . Finally , there is a brief reference to the central role of the spinal cord in mediating and controlling nociception ." ], "offsets": [ [ 0, 993 ] ] } ]

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[]

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DerSchmerz.60100021.eng.abstr

[ { "id": "DerSchmerz.60100021.eng.abstr-passage-0", "type": "abstract", "text": [ "The effects of combined spinal administration of 2-adrenoceptor agonists , local anaesthetics , and opioids have been extensively studied . The motor and the sensory block of spinal and epidural anaesthesia is enhanced and prolonged by the combination of clonidine with the local anaesthetics lidocaine , tetracaine and bupivacaine . Because higher plasma levels of local anaesthetics were measured when clonidine was injected epidurally , the enhancement of the local anaesthetic's effect by clonidine is not due to slowed resorption , but rather to direct spinal and supraspinal effects of clonidine . Furthermore , direct local anaesthetic properties of clonidine on nerve fibres are discussed . In addition , in children the combination of clonidine and bupivacaine for caudal anaesthesia resulted in a marked prolongation of postoperative pain relief . Circulatory effects of combined clonidine and local anaesthetics are the result of the specific spinal blockade and the central and peripheral effects of clonidine . The combined epidural and intrathecal administration of opioids and 2-adrenoceptor agonists provides better postoperative pain relief than the administration of either substance alone . In humans , the interaction seems to be additive rather than supra-additive . Because of its limited duration of action , continuous administration of clonidine is recommended , especially when it is used in combination with opioids . Neither the incidence nor the severity of side effects is increased by a combined therapy with opioids . Despite the sedative properties of clonidine , there is no increased risk of respiratory depression when clonidine is given in combination with opioids . The inhibiting effect on the sympathetic nervous system activity regularly observed during spinal administration of clonidine supports the value of this therapy and will support its use in the future . Therefore , the combination of 2-adrenoceptor agonists with local anaesthetics or opioids is reasonable and may improve anaesthetic practice ." ], "offsets": [ [ 0, 2048 ] ] } ]

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DerSchmerz.60100036.eng.abstr

[ { "id": "DerSchmerz.60100036.eng.abstr-passage-0", "type": "abstract", "text": [ "A 55-year-old female patient developed a severe chronic lumbar pain syndrome over a period of 17 years . An intervertebral disc operation was performed 5 years after the start of the painful illness . The patient later developed resistance to therapy and was unable to stand or walk . She was confined to bed and wheelchair and socially completely withdrawn . Drug therapy and invasive therapeutic techniques escalated . An intrathecal catheter for morphine administration had to be removed owing to bacterial meningitis , and repeated malfunction led to several revisions of an epidural catheter . Withdrawal of the morphine therapy , carried out with the patient's agreement , was complicated by an epileptic seizure and an acute circulatory failure with cerebral hypoxia . The succeeding severe amnestic syndrome extinguished all recollection of the last 20 years , including the entire course of the painfull illness . The patient could then be mobilised without pain . Consistent care avoided a relapse into the pain syndrome as the amnestic syndrome gradually receded . The patient was fully able to accept responsibility and not longer required special pain therapy . The course demonstrates that chronic pain disorders of a predominantly psychodynamic , and therefore corticocerebral , genesis are dependent on an intact memory . In such cases memory failure can induce pain relief ." ], "offsets": [ [ 0, 1391 ] ] } ]

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[]

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DerSchmerz.60100040.eng.abstr

[ { "id": "DerSchmerz.60100040.eng.abstr-passage-0", "type": "abstract", "text": [ "A patient with brachialgia was admitted to a surgical clinic and a cervical nerve block was performed under fluoroscopic guidance . Acute severe cervical pain prevented completion of the procedure . On the following day the patient developed incomplete paralysis of both legs and arms and was transferred to a neurosurgical department for further diagnosis and therapy . The CT scan showed a space-occupying cervical intraspinal haematoma , which was removed immediately as far as possible by a dorsal approach . Postoperatively little improvement of neurologic function was noticed , and 11 days after the event the patient died from a massive pulmonary embolism despite intense resuscitation efforts ." ], "offsets": [ [ 0, 703 ] ] } ]

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[]

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DerSchmerz.60100047.eng.abstr

[ { "id": "DerSchmerz.60100047.eng.abstr-passage-0", "type": "abstract", "text": [ "Four multidimensional inventories used as instruments for the assessment of pain are examined : \" Fragebogen zur Erfassung der Schmerzverarbeitung ' [ Questionnaire for Assessment of Level of Coping with Pain ] , \" Kieler Schmerzverarbeitungs-Inventar' [ Kiel Inventory of Coping with Pain ] , \" Fragebogen zur Schmerzregulation ' [ Questionnaire on Pain Regulation ] , and the German version of the \" Multidimensional Pain Inventory ' . None of these questionnaires assesses all domains that are important in chronic pain . The recommended standardized assessment routine for pain centres includes the use of a diary , the rating of actual , average and maximum pain intensity , the application of the PDI , a measure of disability , and the FESV , which records cognitive processing and coping . As measures of general psychological dysfunction the ADS for the assessment of depression and the B-L , a symptom checklist , are suggested as instruments suitable for routine use in diagnosis and evaluation ." ], "offsets": [ [ 0, 1007 ] ] } ]

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DerSchmerz.60100057.eng.abstr

[ { "id": "DerSchmerz.60100057.eng.abstr-passage-0", "type": "abstract", "text": [ "Spinal clonidine interacts with pre- and postsynaptic 2-adrenoceptors on afferent neurons in the superficial dorsal horn of the spinal cord : it causes analgesia by inhibition of the synaptic and electrotonic neurotransmission of nociceptive impulses . Epidural doses higher than 4 µg/kg have an analgesic onset time of less than 30 min , reduce pain by more than 70 % ; these effects last for 4-5 h . Epidural clonidine analgesia is accompanied by a reduction in heart rate , cardiac output and blood pressure of approximately 20 % compared with baseline . The haemodynamic side effects mean close supervision is needed during the first hour after epidural application and limit the use of epidural clonidine to patients who are refractory to the analgesic effects of epidural opioid or local anaesthetics . In these patients excellent results can be achieved either with clonidine alone or with a combination of clonidine and an opioid or a local anaesthetic to exploit the additive or supra-additive interactions of these drugs ." ], "offsets": [ [ 0, 1032 ] ] } ]

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DerSchmerz.60100065.eng.abstr

[ { "id": "DerSchmerz.60100065.eng.abstr-passage-0", "type": "abstract", "text": [ "The antinociceptive effect of 2-adrenoceptor agonists is mediated by activation of descending inhibiting noradrenergic systems , which modulates ' wide-dynamic-range' neurones . Furthermore , they inhibit the liberation of substance P and endorphines and activate serotoninergic neurones . Despite this variety of antinociceptive actions , there is still little experience with 2-adrenoceptor agonists as therapeutic agents for use in chronic pain syndromes . Studies in animals and patients have shown that the transdermal , epidural and intravenous administration of the 2-adrenoceptor agonist clonidine reduces pain intensity in neuropathic pain syndromes for periods varying from some hours up to 1 month . Patients suffering from lancinating or sharp pain respond best to this therapy . Topically applied clonidine ( 200-300 µg) relieves hyperalgesia in sympathetically maintained pain . Epidural administration of 300 µg clonidine dissolved in 5 ml NaCl 0.9 % has also been shown to be effective . In patients suffering from cancer pain tolerant to opioids , pain control has proved possible again with combinations of opioids and clonidine . In isolated cases clonidine has been administered epidurally at a dose of 1500 µg/day for almost 5 months without evidence for any histotoxic property of clonidine . Side effects often observed during administration of 2-adrenoceptor agonists are dry mouth , sedation , hypotension and bradycardia . Therapeutic interventions are usually not required ." ], "offsets": [ [ 0, 1501 ] ] } ]

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[]

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DerSchmerz.60100071.eng.abstr

[ { "id": "DerSchmerz.60100071.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction . The relationship between depression and the outcome of low back surgery was investigated . Data analysis was based on two assumptions : ( 1 ) Presurgical assessments of depression are correlated with the outcome of surgery , and , therefore , depression can be interpreted as a risk factor for surgical failure . ( 2 ) Postsurgical assessments of depression are correlated with the outcome of surgery , and therefore , depression can be interpreted as a response to treatment failure . Methods . The sample was made up of 78 patients who had undergone lumbar nucleotomy and 132 patients with lumbar spondylodesis . Treatment outcome was evaluated 6 months after surgery in the nucleotomy group and 9 months after surgery in the spondylodesis group . Depression was assessed with the Beck Depression Inventory ( BDI ) . Measures of treatment outcome were an objective rating system for the surgical result , functional impairment , return to work , subjective estimations of the patient , and pain intensity . Results . Presurgical depression scores showed no significant relationship with surgical outcome in nucleotomy patients . In spondylodesis patients , however , there was a significant negative correlation with the patients ' subjective outcome ratings . Postsurgical depression scores , on the other hand , were significantly related to almost all of the outcome variables in both treatment groups . Patients with clinically relevant postsurgical depression scores were significantly more likely not to benefit sufficiently from surgery than those with clinically not relevant depression scores . Discussion . Our findings favour assumption 2 over assumption . 1. In the light of our findings , depressiveness is interpreted as a response to a non-beneficial outcome of surgery . The need for an interdisciplinary approach combining psychological counseling or treatment and physical therapy for those patients who do not benefit from surgery is discussed ." ], "offsets": [ [ 0, 1981 ] ] } ]

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[]

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"type": "evaluation_of", "arg1_id": "DerSchmerz.60100071.eng.abstr-s18-t1", "arg2_id": "DerSchmerz.60100071.eng.abstr-s18-t3", "normalized": [] }, { "id": "DerSchmerz.60100071.eng.abstr-s18-r10-t3.1-t6.1", "type": "issue_in", "arg1_id": "DerSchmerz.60100071.eng.abstr-s18-t3", "arg2_id": "DerSchmerz.60100071.eng.abstr-s18-t6", "normalized": [] } ]

DerSchmerz.60100080.eng.abstr

[ { "id": "DerSchmerz.60100080.eng.abstr-passage-0", "type": "abstract", "text": [ "Aims . Severe pain of mucositis induced by cytostatic conditioning therapy in bone marrow transplantation ( BMT ) patients generally requires continuous parenteral opioid treatment . Cognitive and psychological disturbances are frequent complications subsequent to BMT and may result from cerebral opioid side effects . The aim of the study was to evaluate the efficiency of continuous morphine in mucositis pain and the side-effects in BMT patients . Particular emphasis was placed on the question of whether reaction times , which are usually measured to estimate opioid effects upon vigilance , are influenced by pain-induced cognitive impairments in pain patients . Methods While in hospital , 10 BMT patients were examined daily with the aid of a mucositis scale , subjective visual analog scales ( VAS ) for pain and mood parameters , a German version of the McGill pain questionnaire ( MPQ ) , and a mental performance task battery , and the morphine given was documented . Mental performance tests were simple auditory reaction time and choice reaction time . Seven patients also performed a Sternberg memory search test in which they had to use ' yes ' and ' no ' response keys to match visually presented test letters to a previously memorized set of letters . Practice and baseline data were collected within the first week before BMT . Results The intensity and duration of mucositis differed from patient to patient , resulting in different pain intensities and MPQ scores . Prolongation of the choice reaction time averaged over the period of mucositis treatment correlated significantly with residual pain intensity ( Spearman rs = 0.88 , p 0.01 ) but not with morphine dose ( rs = 0.35 , p = 0.33 ) . For the Sternberg memory search test greater correlation coefficients resulted between reaction time and morphine dose ( rs = 0.86 , p = 0.014 ) than between reaction time and residual pain intensity ( rs = 0.61 , p = 0.15 ) . In turn , pain intensity , unlike morphine dose , was significantly correlated with high scores in the mood parameters for depression , passivity , and tiredness . Conclusions It is concluded that both pain and morphine can impair cognitive performance , but that these mental stressors seem to differ according to qualitative criteria . Whereas pain might slow reaction time by distracting a patient's attention , particularly in low mental demand tasks , morphine could interfere with more specific cognitive processes , such as short-term memory operations , that are required in more complex tasks ." ], "offsets": [ [ 0, 2547 ] ] } ]

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"id": "DerSchmerz.60100080.eng.abstr-s15-r22-t6.2-t5.1", "type": "result_of", "arg1_id": "DerSchmerz.60100080.eng.abstr-s15-t6", "arg2_id": "DerSchmerz.60100080.eng.abstr-s15-t5", "normalized": [] }, { "id": "DerSchmerz.60100080.eng.abstr-s15-r23-t4.1-t5.1", "type": "affects", "arg1_id": "DerSchmerz.60100080.eng.abstr-s15-t4", "arg2_id": "DerSchmerz.60100080.eng.abstr-s15-t5", "normalized": [] } ]

DerSchmerz.60100089.eng.abstr

[ { "id": "DerSchmerz.60100089.eng.abstr-passage-0", "type": "abstract", "text": [ "Utilizing MEDLINE and PSYCLIT , a search for articles covering psychological research on pain in the Western European countries was undertaken for the period from 1 January 1990 to 31 December 1994. A total of 398 publications were identified , of which 44 were classified as experimental research in the laboratory , 33 as psychodiagnostic and 225 as clinical studies . The most frequent diagnosis was back pain , followed by musculoskeletal pain and headache . With regard to the total number of publications , Germany was first , followed by The Netherlands and Great Britain . In an analysis of the subcategories , the leading position of Germany could only be confirmed with respect to laboratory studies ; in psychodiagnostic publications , Germany fell back behind Great Britain and The Netherlands . In clinical studies , Germany was second to Sweden . Relating the number of publications to the number of personnel estimated to be engaged in research , The Netherlands and the Scandinavian countries demonstrate very high efficiency . Compared with Germany , these countries facilitate the integration of psychological procedures into an interdisciplinary management of pain ." ], "offsets": [ [ 0, 1185 ] ] } ]

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"Germany" ], "offsets": [ [ 747, 754 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "Netherlands" ], "offsets": [ [ 794, 805 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027778" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "Great Britain" ], "offsets": [ [ 772, 785 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018223" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 830, 837 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "Sweden" ], "offsets": [ [ 852, 858 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038995" } ] }, { "id": "DerSchmerz.60100089.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "clinical studies" ], "offsets": [ [ 811, 827 ] ], "normalized": [ { 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[]

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DerSchmerz.60100093.eng.abstr

[ { "id": "DerSchmerz.60100093.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the present study was to examine the value of the sympathetic skin response ( SSR ) in the diagnosis of reflex sympathetic dystrophy ( RSD ) ." ], "offsets": [ [ 0, 153 ] ] } ]

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[]

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DerSchmerz.60100121.eng.abstr

[ { "id": "DerSchmerz.60100121.eng.abstr-passage-0", "type": "abstract", "text": [ "Stimulating afferent fibers of the trigeminal nerve usually causes two successive suppressions ( ES1 and ES2) of the voluntary muscle activity of chewing muscles . The first phase of decreased voluntary activity is called the early exteroceptive suppression period ( ES1); the second phase is called the late exteroceptive suppression period ( ES2). Between these two suppression periods is a phase of increased muscle activity , the so-called facilitation period ( FP ) . Usually , in healthy subjects this normal pattern of exteroceptive suppression can be elicited regularly . The reflex answer may occur at low non-painful stimulus intensities ; however , typically it appears to be most pronounced with high-intensity stimuli . Because of the obvious relationship between stimulus intensity , pain perception and reflex answer , the reflex is regarded as an antinociceptive reaction . Chronic pain syndromes like chronic tension-type headache and migraine without aura cause changes within the normal ES recording pattern . Furthermore , some substances used in pain therapy such as serotoninagonists or antagonists , acetylsalicylic acid or naloxon may also alter the general appearance of the ES . In this review different parameters that influence the ES reflex answer are summarized . Above , the diagnostic value of the changes of the ES for pathophysiological procedures regarding pain perception and pain processing in certain pain diseases is discussed ." ], "offsets": [ [ 0, 1467 ] ] } ]

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"umlsterm", "text": [ "syndromes" ], "offsets": [ [ 903, 912 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "headache" ], "offsets": [ [ 939, 947 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 952, 960 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "aura" ], "offsets": [ [ 969, 973 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0236018" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "pain syndromes" ], "offsets": [ [ 898, 912 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0391976" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "tension-type headache" ], "offsets": [ [ 926, 947 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033893" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s6-t8", "type": "umlsterm", "text": [ "migraine without aura" ], "offsets": [ [ 952, 973 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0338480" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1067, 1071 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 1072, 1079 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "antagonists" ], "offsets": [ [ 1109, 1120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243076" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 1139, 1143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "pain therapy" ], "offsets": [ [ 1067, 1079 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002766" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s7-t6", "type": "umlsterm", "text": [ "acetylsalicylic acid" ], "offsets": [ [ 1123, 1143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004057" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "review" ], "offsets": [ [ 1213, 1219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282443" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "reflex" ], "offsets": [ [ 1263, 1269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034929" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 1306, 1316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "value" ], "offsets": [ [ 1317, 1322 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s9-t3", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 1371, 1381 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s9-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1392, 1396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s9-t5", "type": "umlsterm", "text": [ "perception" ], "offsets": [ [ 1397, 1407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030971" } ] }, { "id": "DerSchmerz.60100121.eng.abstr-s9-t6", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1412, 1416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": 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DerSchmerz.60100135.eng.abstr

[ { "id": "DerSchmerz.60100135.eng.abstr-passage-0", "type": "abstract", "text": [ "First time experienced severe headache combined with fever or meningism requires immediate evaluation by computer tomography ( CT ) to exclude subarachnoidal or cerebral hemorrhage , hydrocephalus or a tumor . If CT is normal , lumbar puncture must be performed to exclude meningitis and meningoencephalitis . Chronic or chronic recurrent headache without focal neurological deficits does not require EEG or CT . CT must be performed if the headache characteristics change or if the headache is combined with neurological deficits ." ], "offsets": [ [ 0, 532 ] ] } ]

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[]

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DerSchmerz.60100140.eng.abstr

[ { "id": "DerSchmerz.60100140.eng.abstr-passage-0", "type": "abstract", "text": [ "Whether the primary mechanisms of migraine are vascular or neurogenic is , as yet unresolved . Early studies using Doppler sonography prompted heterogeneous results , mainly due to methodological differences . However , blood flow measurements using single photon emission tomography ( SPECT ) or positron emission tomography ( PET ) have not revealed any differences in cerebral blood flow in migraine without aura . Moreover , specific migraine compounds do not alter cortical blood flow . During attacks , increased blood flow is found in the cerebral hemispheres in cingulate , auditory and visual association cortices and the brain stem . Alltogether , these findings suggest that the pathogenesis of migraine is related to an imbalance in activity between brain stem nuclei regulating antinociception and vascular control , rather than in primary vessel diameter changes ." ], "offsets": [ [ 0, 878 ] ] } ]

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[]

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"DerSchmerz.60100140.eng.abstr-s6-r23-t6.1-t8.2", "type": "produces", "arg1_id": "DerSchmerz.60100140.eng.abstr-s6-t6", "arg2_id": "DerSchmerz.60100140.eng.abstr-s6-t8", "normalized": [] }, { "id": "DerSchmerz.60100140.eng.abstr-s6-r24-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.60100140.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.60100140.eng.abstr-s6-t4", "normalized": [] }, { "id": "DerSchmerz.60100140.eng.abstr-s6-r25-t8.2-t6.1", "type": "disrupts", "arg1_id": "DerSchmerz.60100140.eng.abstr-s6-t8", "arg2_id": "DerSchmerz.60100140.eng.abstr-s6-t6", "normalized": [] } ]

DerSchmerz.60100146.eng.abstr

[ { "id": "DerSchmerz.60100146.eng.abstr-passage-0", "type": "abstract", "text": [ "A menstrual migraine occurs in approximately 7-10 % of women suffering from migraine . The migraine occurs from 2 days before until 3 days after the end of the menstrual period . The choice of treatment depends on the duration of the attack , which ranges from 3 to 7 days . An attack of up to 3 days duration should be treated with acetylsalicylic acid , ergotamine tartrate or naproxen , each in combination with an antiemetic ( domperidone , metoclopramide ) . If there is no response , sumatriptan can be administered orally ( 25-100 mg ) or subcutaneously ( 6 mg ) . In the attacks continue for more than 3 days , short-term prophylaxis with naproxen or the application of an estrogen-containing patch is indicated . Neither ovulation inhibitors nor traditional migraine prophylaxis has an influence on menstrual migraine . Patients should keep a headache diary . Short-term prophylaxis with ergotamine tartrate or tamoxifen is obsolete ." ], "offsets": [ [ 0, 943 ] ] } ]

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"offsets": [ [ 183, 189 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008300" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 193, 202 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "acid" ], "offsets": [ [ 349, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001128" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "ergotamine" ], "offsets": [ [ 356, 366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014710" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "ergotamine" ], "offsets": [ [ 356, 366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002508" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "tartrate" ], "offsets": [ [ 367, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0144544" }, { "db_name": "UMLS", "db_id": "C0039328" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "naproxen" ], "offsets": [ [ 379, 387 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027396" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "antiemetic" ], "offsets": [ [ 418, 428 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003297" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "domperidone" ], "offsets": [ [ 431, 442 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013015" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "metoclopramide" ], "offsets": [ [ 445, 459 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025853" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "acetylsalicylic acid" ], "offsets": [ [ 333, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004057" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "ergotamine tartrate" ], "offsets": [ [ 356, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086248" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "sumatriptan" ], "offsets": [ [ 490, 501 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0075632" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "prophylaxis" ], "offsets": [ [ 630, 641 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033107" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "naproxen" ], "offsets": [ [ 647, 655 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027396" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "ovulation" ], "offsets": [ [ 730, 739 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029965" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "inhibitors" ], "offsets": [ [ 740, 750 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243077" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 767, 775 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "prophylaxis" ], "offsets": [ [ 776, 787 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033107" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 818, 826 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 829, 837 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "headache" ], "offsets": [ [ 852, 860 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018681" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "diary" ], "offsets": [ [ 861, 866 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376660" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "prophylaxis" ], "offsets": [ [ 880, 891 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033107" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "ergotamine" ], "offsets": [ [ 897, 907 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014710" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s9-t3", "type": "umlsterm", "text": [ "ergotamine" ], "offsets": [ [ 897, 907 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002508" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s9-t4", "type": "umlsterm", "text": [ "tartrate" ], "offsets": [ [ 908, 916 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0144544" }, { "db_name": "UMLS", "db_id": "C0039328" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s9-t5", "type": "umlsterm", "text": [ "tamoxifen" ], "offsets": [ [ 920, 929 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039286" } ] }, { "id": "DerSchmerz.60100146.eng.abstr-s9-t6", "type": "umlsterm", "text": [ "ergotamine tartrate" ], "offsets": [ [ 897, 916 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086248" } ] } ]

[]

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"DerSchmerz.60100146.eng.abstr-s9-r4-t4.1-t1.1", "type": "interacts_with", "arg1_id": "DerSchmerz.60100146.eng.abstr-s9-t4", "arg2_id": "DerSchmerz.60100146.eng.abstr-s9-t1", "normalized": [] } ]

DerSchmerz.60100149.eng.abstr

[ { "id": "DerSchmerz.60100149.eng.abstr-passage-0", "type": "abstract", "text": [ "Acupuncture is now being increasingly used in the treatment of headache . Acupuncture is a technique originating in Asia , from countries that have a cultural background with a fundamentally different concept of disease and therapy . Up to now , sustained application of acupuncture in Western medicine has been impeded by the lack of a scientifically convincing explanation of the mechanisms of action in terms of neurobiological criteria . Acupuncture is being used empirically in the treatment of migraine ; clinical studies have been published . A definitive evaluation of acupuncture based on well-founded clinical experimental studies has yet to be made . The investigation was carried out in migraine patients who were divided into two subgroups in a control group design with two different stimulation techniques . The verum group was treated with the correct point location , normal prick depth and elicitation of a needle sensation . The control group received treatment at points that are far away from the acupuncture points , using a superficial prick technique and without eliciting a needle sensation . The effect of therapy was appraised by means of headache diaries with subsequent interference statistical and individual case analysis . In the present study comprising 81 patients , the incidence of the attacks was significantly reduced in both subgroups . The effect of acupuncture treatment was of comparable magnitude to that of the beta-blocker metoprolol . The advantage of acupuncture treatment consists in the lack of side effects such as gastrointestinal symptoms or an increase in weight . A minor side effect was only reported in one case . In the data analysis with the interference statistical method , verum acupuncture was superior to the control in only one subgroup . The possibility that the addition of further points ( distant points ) can explain this effect on the basis of the hypothesis of a central modulation of the migraine process is discussed . Acupuncture shows a sufficiently pronounced and sustained therapeutic effect for its use to be considered in a possible interval treatment of migraine ." ], "offsets": [ [ 0, 2144 ] ] } ]

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[]

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DerSchmerz.60100156.eng.abstr

[ { "id": "DerSchmerz.60100156.eng.abstr-passage-0", "type": "abstract", "text": [ "Homeopathy as an alternative to conventional therapy is becoming increasingly popular . Although interest is rising , little is known about the real effectiveness of homeopathic therapy in headaches . Three studies addressing this question are discussed : an Italian migraine study , the London migraine study and our own , the Munich headache trial . While the first one reported very high effects , the best ones known in the literature , the results of the other two trials do not endorse this first finding . The London trial did not show any effect other than placebo , although a different time trend was reported . The Munich study failed to show any difference between homeopathy and placebo whatsoever . The merits and shortcomings of these studies are discussed . At present , we do not have any evidence that homeopathic therapy has any effect other than a placebo effect . However , this can be very impressive sometimes . We do not know which variables are correlated with placebo effectiveness , and we do not have any data on real-type homeopathy outside a trial setting , as there are no data available ." ], "offsets": [ [ 0, 1120 ] ] } ]

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[]

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DerSchmerz.60100169.eng.abstr

[ { "id": "DerSchmerz.60100169.eng.abstr-passage-0", "type": "abstract", "text": [ "According to semiotics , which may be defined as the doctrine of the essential nature and fundamental varieties of signs , objects , and interpretants , pain is considered to be a sign ( significant ) with very different meanings ( significance ) either as a naturalistic symptom ( of disease ) or as a symbol used in a metaphorical context . When following this methodological perspective it is possible to interpret medical as well as poetic writings on equal terms . In Graeco-Roman medical texts pain was mostly understood as a result and an indicator of disease , but nonetheless as a symptom which seemed to be actively produced by the affected body . Especially in the Corpus Hippocraticum dating from the 5th and 4th century B. C. this materialistic and at the same time psychosomatic attitude can be noticed . Aristotle ( 4th century B. C. ) , Celsus ( 1st century A. D. ) , and the famous experimental physiologist Galen ( 2nd century A. D. ) agreed that pain was a sign of evil which should be fought without exception . It was Galen who added the disturbance of function ( functio laesa ) as the fifth cardinal sign of inflammation to the four well-known cardinal signs of Celsus ( rubor , calor , tumor , dolor ) . He also coined the term µK to characterize an attack of migraine . In algotherapy , Galen used a complex pharmacological system which was based upon the four cardinal qualities of humoral pathology . On the other hand , pain was designed as a multi-dimensional symbol by the famous Graeco-Roman epic poets . In Homer's Odyssey ( 8th century B. C. ) , pain appears transformed into the shape of a scar which is visible and palpable on the hero's leg like an identification tag , whereas in Virgil's Aeneids ( 1st century B. C. ) pain symbolizes weakness and defencelessness which can only be alleviated by the goddess Venus ." ], "offsets": [ [ 0, 1852 ] ] } ]

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"inflammation" ], "offsets": [ [ 1131, 1143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021368" } ] }, { "id": "DerSchmerz.60100169.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "signs" ], "offsets": [ [ 1176, 1181 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220912" } ] }, { "id": "DerSchmerz.60100169.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "tumor" ], "offsets": [ [ 1210, 1215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerSchmerz.60100169.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "dolor" ], "offsets": [ [ 1218, 1223 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100169.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 1284, 1292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.60100169.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "pathology" ], "offsets": [ [ 1416, 1425 ] ], "normalized": [ { "db_name": 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"id": "DerSchmerz.60100169.eng.abstr-s10-t4", "type": "umlsterm", "text": [ "hero's" ], "offsets": [ [ 1666, 1672 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0605770" } ] }, { "id": "DerSchmerz.60100169.eng.abstr-s10-t5", "type": "umlsterm", "text": [ "leg" ], "offsets": [ [ 1673, 1676 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "DerSchmerz.60100169.eng.abstr-s10-t6", "type": "umlsterm", "text": [ "identification" ], "offsets": [ [ 1685, 1699 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020792" } ] }, { "id": "DerSchmerz.60100169.eng.abstr-s10-t7", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1756, 1760 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100169.eng.abstr-s10-t8", "type": "umlsterm", "text": [ "weakness" ], "offsets": [ [ 1772, 1780 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086525" }, { "db_name": "UMLS", "db_id": "C0030552" } ] }, { "id": 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DerSchmerz.60100176.eng.abstr

[ { "id": "DerSchmerz.60100176.eng.abstr-passage-0", "type": "abstract", "text": [ "Spinal opioids are effective analgesics for surgical and non-surgical pain . Central and systemic side effects are less frequent than with epidural local anaesthetics or parenteral opioids . This review focuses on the analgesic efficacy of spinal opioids and their combination with local anaesthetics for postoperative analgesia , including patient-controlled epidural analgesia . Intrathecal administration of opioids has some advantages over their administration by the epidural route . Several factors may influence selection of the opioid ; however , in most situations morphine is the drug of choice . Thoracic epidural administration of opioids seems to have no clinically important advantages over the lumbar route in terms of quality of analgesia , adverse effects , doses required or pulmonary function . However , evidence suggesting that effective postoperative analgesia can significantly improve postoperative morbidity in patients at risk is accumulating . In such patients , combined use of epidural local anaesthetics and opioids may become the technique of choice for postoperative analgesia . However , there is no evidence that this would have any clinically relevant benefit in low-risk patients ." ], "offsets": [ [ 0, 1217 ] ] } ]

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DerSchmerz.60100190.eng.abstr

[ { "id": "DerSchmerz.60100190.eng.abstr-passage-0", "type": "abstract", "text": [ "A multimodal treatment program is presented in cases of functional restoration for chronic low back pain . The study comprises four parts . Part I gives an overview of the different results of the study . Part II focuses on the medical and functional examination in comparison with persons who do not suffer from back pain . Part III describes psychosocial aspects ( depression , complaints , ways of coping , disability ) and psychotherapy . In part IV prognostic factors and their reliability for predicting treatment outcome ( return to work , pain intensity , self-assessment of success by patients ) are examined . In addition the relevant effects of the program on social and health care systems are also addressed . Problem The incidence of low back pain is continuously increasing , causing tremendous costs for the health insurance system . Therefore effective treatment methods are needed that take into account somatic , psychological and social factors . Chronic low back pain is conceptualized as a complex phenomenon including biological , social and psychological aspects , all of which should be addressed in a treatment program . A multimodal treatment program for chronic low back pain is presented , in which physical activity and cooperation of the patient are the primary targets . Therapeutic aims focus less on pain reduction and emphasize instead pain control , individual responsibility of the patient , and early reintegration into the working environment . The specific goals of the program are to increase the physical abilities of the patients ( i . e . , flexibility , strength and endurance ) , to increase patients ' knowledge and the use of body mechanics and back protection techniques , to decrease medication-intake , to decrease dependency on the medical community , to improve patients ' own positive coping skills and levels of emotional control , to increase the patient's activity level at home and to facilitate a return to work . Methods A total of 90 disabled patients with chronic low back pain were admitted to an 8-week program of functional restoration and behavioral support . The program consisted of a pre-program ( 3 weeks : education , stretching and calisthenic exercises ) and an intensive treatment period ( aerobics , functional strength and endurance exercises , back exercises , cognitive behavioral group therapy , relaxation training , socioeconomic and vocational counseling ) which took place for 5 weeks , 7 h a day , on an outpatient basis . Apart from a medical examination and a personal interview , the patients ' physical impairment , pain descriptions , and psychological distress ( according to different criteria for evaluation ) were also measured . This includes variables such as depression , psychovegetative complaints , quality of life and workplace satisfaction , disability , and coping with disease . Measurements were repeated at the end of the 8-week program , and after 6 and 12 months . Results In total 84 patients ( 94 % ) were examined following treatment . There was a statistically significant improvement in flexibility , strength , lifting capacity , and endurance measurements ( p 0.001 ) at the end of the treatment . In addition , significant reductions in pain , disability , depression , and psychovegetative signs were demonstrated ( p 0.001 ) . There was a decreased use of medical treatment for back pain following the program , with 42 % of the patients refraining from the intake of analgesics , followed by a significant reduction in physiotherapy and the consultation of physicians . Assessment of the patients ' reported increased activity levels at home also supported findings that statistical improvements were significant . Sixty-three percent of the patients were found to have returned to active , productive work following discharge from the program . Most of the improvements remained stable at the 6- and 12-month follow-up examinations . Conclusion The results demonstrate the effect ." ], "offsets": [ [ 0, 4000 ] ] } ]

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[]

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DerSchmerz.60100237.eng.abstr

[ { "id": "DerSchmerz.60100237.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem There is a great need to expand current knowledge of the various functional capacity measurements used in the rehabilitation of chronic low back pain ( CLBP ) patients . The literature on these patients reports that mobility , endurance , trunk strength and lifting capacity decrease during the process of chronicity . Chronically disabled patients appear to have lower functional capacity than asymptomatic persons . Methods Our study group consisted of 90 disabled CLBP patients ( 44 female , 46 male ; average age 42 years ) who underwent a multidisciplinary 8-week daily treatment program of functional restoration with behavioral support ( instruction , endurance training , strength exercises , behavioral and treatment to facilitate return to work therapy ) . Initially these patients where compared with 107 asymptomatic persons ( 44 female , 63 male , average age 41 years ) . The patients were investigated before and after treatment , and at intervals of 6 and 12 months . The reliability of the functional measurements was evaluated by interrater comparison . Physical assessment included a medical examination ( mainly diagnosis of radicular or nonradicular pain ) , changes in the lumbar spine revealed by X-ray studies according to Herron and Turner [ 50 ] , rating of physical impairment according to Waddell [ 117 ] , flexibility , length of hamstrings muscles ( SLR ) , test of power and endurance of trunk movement by standardized exercises according to the Swiss group of Spring [ 102 ] and isokinetic measurements ( LIDO Back ) , tests of lifting capacity ( LIDO Lift ) , and ( in part ) of general endurance on a cycle ergometer ( CASE 15 Marquette ) . Results Physical findings showed that mobility was reduced substantially in patients suffering from back pain due to reduced SLR ( shortened hamstrings ) and decreased spinal mobility . Patients also demonstrated significant reductions in their ability to perform lifting tasks in comparison to healthy individuals . The results of trunk flexion showed no significant differences between patients and the control group , whereas the ability to perform trunk extension was much better in the control group . In principle we found the same results with isokinetic measurements as in the exercises without machines . Cardiovascular endurance was also much better in the control group than it was in the back pain patients . At the end of the treatment program all physical deficits were improved significantly . In many cases performance was comparable with that of the control group . With time , however , training effects gradually decreased . The success of treatment ( return to work , absence from work , pain reduction , use of medical care ) was independent of the functional status of the patients before and after treatment . Conclusion Study results showed that physical capacity in disabled patients with low back pain is substantially reduced in comparison to persons who do not suffer from back pain . The only exception was in trunk flexor strength and endurance , in which measurements did not differ between the patients and the control group . However , even CLBP- patients with long-term pain and severe physical illness can successfully improve their physical condition by participating in an active treatment program . Back extensor muscle training has to be included in physical therapy . Because of loss of condition during the time after treatment , regular monitoring of patients and their home training programs is necessary . Overall , treatment of CLBP has to include physical training and psychosocial treatment to achieve satisfactory results ." ], "offsets": [ [ 0, 3654 ] ] } ]

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[]

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"arg1_id": "DerSchmerz.60100237.eng.abstr-s23-t2", "arg2_id": "DerSchmerz.60100237.eng.abstr-s22-t4", "normalized": [] }, { "id": "DerSchmerz.60100237.eng.abstr-s22-r5-t2.1-t4.2", "type": "performs", "arg1_id": "DerSchmerz.60100237.eng.abstr-s23-t2", "arg2_id": "DerSchmerz.60100237.eng.abstr-s22-t4", "normalized": [] }, { "id": "DerSchmerz.60100237.eng.abstr-s22-r6-t2.1-t8.1", "type": "performs", "arg1_id": "DerSchmerz.60100237.eng.abstr-s23-t2", "arg2_id": "DerSchmerz.60100237.eng.abstr-s22-t8", "normalized": [] } ]

DerSchmerz.60100254.eng.abstr

[ { "id": "DerSchmerz.60100254.eng.abstr-passage-0", "type": "abstract", "text": [ "Tramadol , a mixed µ-opioid agonist and a monoamine-reuptake blocking analgesic , has been supposed to have little effect on propulsive gastrointestinal motility . However , this has not been specifically studied in man . Following institutional approval , 18 human volunteers were given 50 mg of tramadol , tilidine/naloxone , and codeine , respectively , in a double-blind randomised cross-over design . Additionally , 12 further volunteers were given 100 mg of each opioid in a double-blind , randomised fashion , followed by measurement of gastrocoecal transit time . Gastrointestinal transit time was measured using the lactulose H2-breath test . A threefold increase in end-expiratory hydrogen when compared to the control value was considered the end point of gastrocoecal transit . At the low dose ( 50 mg ) the three opioids did not differ significantly with regard to their effect on gastrointestinal motility . Gastrocoecal transit time was 90.8 ( +/- 10.1 SEM ) min for tramadol , 100.6 ( +/- 9.8 SEM ) min for tilidine/naloxone , and 104.2 ( +/- 8.7 SEM ) min for codeine . Doubling the dose of each opioid resulted in an increase in mean gastrocoecal transit , namely 97.8 ( +/- 11.2 SEM ) min for tramadol , 129.2 ( +/- 12.2 SEM ) min for tilidine/naloxone and 135.9 ( +/- 9.2 SEM ) min for codeine . The increase in gastrocoecal transit time was significant ( P 0.01 ) for high doses of tilidine/naloxone and codeine in contrast to the effect of the low doses . This lesser constipation effect may be due to the reduced affinity of tramadol to the µ-opioid receptor . Sedation was significantly higher for codeine after 50 mg ( P 0.05 ) and 100 mg ( P 0.005 ) than for tilidine/naloxone and tramadol . Vertigo was significantly higher after 50 mg ( P 0.05 ) and 100 mg ( P 0.005 ) of tilidine/naloxone and codeine than after tramadol . Perspiration was significantly higher after tramadol 100 mg ( P 0.005 ) than after tilidine/naloxone and codeine . Sedation is considered a typical symptom of analgesics interacting with centrally located opioid receptor sites . The higher incidence of perspiration after tramadol suggests that monominergic pathways may be involved in thermoregulation . In conclusion , the opioids tilidine/naloxone and codeine at the doses used significantly prolong gastrointestinal transit time in the high-dose range . Since tramadol does not induce a dose-related increase in gastrocoecal transit time , it may be a useful analgesic in patients who are prone to developing constipation during high-dose opioid therapy ." ], "offsets": [ [ 0, 2561 ] ] } ]

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"normalized": [] } ]

DerSchmerz.60100261.eng.abstr

[ { "id": "DerSchmerz.60100261.eng.abstr-passage-0", "type": "abstract", "text": [ "The etiology of trigeminal neuralgia is unknown , but both peripheral and central causes have been suggested . To investigate the role of central neurochemical mechanisms we measured epinephrine , norepinephrine and their breakdown product , vanilly mandelic acid ( VMA ) , in the cerebrospinal fluid ( CSF ) of 16 patients ( 53.3 +/- 8.3 years ) suffering from trigeminal neuralgia . As markers for the dopaminergic system , we determined CSF levels of dopamine and its metabolite homovanillic acid ( HVA ) . As a marker for the serotonergic system , we measured CSF levels of serotonin metabolite 5-hydroxyindoleacetic acid ( 5-HIAA ) . In addition , levels of the neuropeptides substance P and somatostatin were determined . The concentration of norepinephrine ( P 0.01 ) , VMA ( P 0.05 ) and HVA ( P 0.05 ) were significantly decreased in patients with trigeminal neuralgia and correlated with the duration of the disease and depression scores . 5-HIAA was also significantly decreased ( P 0.05 ) compared to control patients . Whereas substance P was significantly elevated ( P 0.05 ) , somatostatin was significantly decreased ( P 0.05 ) . Various correlations between the classical neurotransmitters and the neuropeptides could be established . We hypothesize than the sum of complex neurochemical changes plays a role in the etiology of trigeminal neuralgia , which can be separated in local and more central proceedings . The increase in substance P , a major nociceptive neuromodulator , supports the concept of a local neurogenic inflammation , possibly located in the trigeminovascular system . Depending on the duration of the disease and depression , the loss of serotonergic , dopaminergic and noradrenergic innervation seems to reflect more central changes , possibly due to alterations in their antinociceptive descending pathways ." ], "offsets": [ [ 0, 1849 ] ] } ]

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"type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 315, 323 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "neuralgia" ], "offsets": [ [ 373, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027796" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "mandelic acid" ], "offsets": [ [ 250, 263 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0065636" }, { "db_name": "UMLS", "db_id": "C0024685" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "cerebrospinal fluid" ], "offsets": [ [ 281, 300 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007807" }, { "db_name": "UMLS", "db_id": "C0007806" } ] }, { "id": "DerSchmerz.60100261.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "trigeminal neuralgia" ], "offsets": [ [ 362, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040997" } ] }, { "id": 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[]

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"arg2_id": "DerSchmerz.60100261.eng.abstr-s12-t1", "normalized": [] }, { "id": "DerSchmerz.60100261.eng.abstr-s12-r10-t4.1-t2.1", "type": "result_of", "arg1_id": "DerSchmerz.60100261.eng.abstr-s12-t4", "arg2_id": "DerSchmerz.60100261.eng.abstr-s12-t2", "normalized": [] }, { "id": "DerSchmerz.60100261.eng.abstr-s12-r11-t1.1-t4.1", "type": "result_of", "arg1_id": "DerSchmerz.60100261.eng.abstr-s12-t1", "arg2_id": "DerSchmerz.60100261.eng.abstr-s12-t4", "normalized": [] } ]

DerSchmerz.60100269.eng.abstr

[ { "id": "DerSchmerz.60100269.eng.abstr-passage-0", "type": "abstract", "text": [ "Besides the treatment of postoperative pain , working together with the anaesthesiologist , orthopaedic doctors are mostly involved in diseases of the locomotor system where pain is a leading feature . Painful orthopaedic diseases are very frequent . They afford a special diagnostic procedure . The pain treatment consists of special orthopaedic therapy and local injections with low doses of local anaesthetics and steroids at the site of pain . This treatment helps to avoid the use of high-dose systemic analgesics and perhaps avoids the need for operations ." ], "offsets": [ [ 0, 563 ] ] } ]

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[]

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DerSchmerz.60100283.eng.abstr

[ { "id": "DerSchmerz.60100283.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction . Treatment of chronic cancer pain with strong opioids is indicated in about 60-70 % of patients . Surprisingly , these very potent analgesics are prescribed with great reservations in many countries , including Germany . The aim of our investigation was to analyse the supply of opioid analgesics to outpatients with cancer pain in the region of Hannover , which has about 1.1 million inhabitants . Methods . In Germany special prescription forms , i . e . triplicate forms , have to be used for the prescription of strong opioids . At the time when our investigation took place prescriptions for outpatients had to be renewed every 7 days . For two observation periods of 6 months lasting from January to June 1988 and from January to June 1991 all of the opioid prescription forms that had been issued by general practitioners for clients of the AOK Hannover ( one of the major medical insurance companies ) were evaluated . The reasons for prescribing opioids were analysed by recording the diagnosis . The individual treatment period on an outpatient basis during these 6 months was determined , excluding , e . g . days of hospitalization . Results . During the two observation periods only 16.2 % ( 1988 ) and 19.5 % ( 1991 ) of the practitioners in the region of Hannover prescribed strong opioids to outpatients . The majority of the practitioners consisted of general practitioners and specialists in internal medicine . Although these two groups mainly function as family doctors who are responsible for the basic therapeutical needs of their patients , only 22.6-33.8 % of these doctors prescribed opioids to outpatients . In two-thirds of the patients , cancer pain was the reason for prescribing the drug . The total number of patients with a prescription for cancer pain was 164 in 1988 and 196 in 1991. Altogether 1002 prescription forms in 1988 and 1065 prescription forms in 1991 had been issued for these patients . Applied to the individual treatment period as an outpatient , only 36.0 % of the patients in 1988 and 32.1 % in 1991 received a regular prescription of strong opioids every 7 days . The mean time interval between separate prescriptions was 16.8 +/- 25.4 days in 1988 and 19.4 +/- 29.1 days in 1991. Accordingly , the majority of patients with chronic cancer pain had been supplied with opioids only occasionally . Conclusion . Our data indicate a significant undertreatment of outpatients suffering from cancer pain . Taking into account the estimated total number of patients suffering from cancer , only 14.5 % ( 1988 ) and 19.0 % ( 1991 ) of all outpatients in need of strong opioids were supplied sufficiently with those analgesics . Comparing the results from the observation period in 1988 with the results from 1991 it becomes obvious that the situation has not changed . There are different reasons for the insufficiency of opioid treatment : many physicians as well as their patients are still afraid of the side effects of strong opioids . Therefore , it is necessary to improve education concerning this issue . The legal restrictions on the use of narcotics and their complexity are another important reason for doctors not to prescribe strong opioids . In 1993 the regulations were simplified ; nevertheless , this has not led to a profound change in the attitude of the prescribing practitioners . Thus , further changes in legislation seem to be necessary so that the requirements for the prescription of strong opioids do not differ from other drugs ." ], "offsets": [ [ 0, 3515 ] ] } ]

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DerSchmerz.60100292.eng.abstr

[ { "id": "DerSchmerz.60100292.eng.abstr-passage-0", "type": "abstract", "text": [ "The prescription of strong opioide by general practitioners was studied , particularly for the treatment of chronic pain . In a medium-sized town ( around 250 000 inhabitants ) 17,839 prescriptions of strong opioids were issued by 455 doctors over 5 years ( 1 January 1990 until 31 December 1994 ) to 1,939 patients . Of these patients 37.8-48.3 % of them received only one prescription for 6 months , 60.5-75.8 % received between 1 and 4 prescriptions for 6 months , and only 20.9-35.7 % of all patients received 5 or more prescriptions for 6 months . The amount of strong opioids prescribed for cancer pain relief seems to be almost the same in 1992 as 10 years ago . The consumption of oral morphine has steadily increased compared to 1982 and constitutes almost one-half of all narcotics prescribed for pain treatment by general practitioners . For pain treatment the value of strong opioids is recognized by both patients and physicians in contrast to the prescription of levomethadone as substitution therapy for drug-addicted patients . The 6.7 % of the physicians who participated in methadone substitution therapy prescribed more strong opioids ( 52.4 % of prescriptions ) than all other physicians together prescribe for pain treatment . In order to safeguard the quality of medical care for pain treatment by strong opioid analgesics , unbiased training of physicians and a clear definition of narcotics is required . It is suggested that the expression \" narcotic prescription \" be changed related to the legislative terminology in the pharmacology-related expression \" analgesic prescription \" . The prescribing regulations should not constrain medical treatment , but create a basic rule for the prescription of strong opioids ." ], "offsets": [ [ 0, 1742 ] ] } ]

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DerSchmerz.60100299.eng.abstr

[ { "id": "DerSchmerz.60100299.eng.abstr-passage-0", "type": "abstract", "text": [ "The present legal requirements for the prescription of controlled drugs remains an impediment to adequate therapy for chronic pain because of an abundance of legal regulations . The physician prescribing opioids must consider the permitted maximum amount per prescription , the period of time the drug is prescribed for , numerous cross references , and other special regulations , and he still cannot be sure that he does not violate certain legal requirements . Often these difficulties result in withholding necessary pain treatment ! In the authors ' opinion it should be sufficient to write a specific prescription form for controlled drugs in the same way as any other ordinary prescription without jeopardizing the safety of the drug control system . It is important that the use of the narcotic be justified in the sense of § 13 Abs. 1 of the drug control regulation , as judged by the responsible prescriber of the drug , and that any offence be punished . The use of triplicate prescriptions guarantees sufficient proof . Legislation is requested that will substitute for the present drug control regulations , which are difficult to handle ." ], "offsets": [ [ 0, 1152 ] ] } ]

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"UMLS", "db_id": "C0243148" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "drug control" ], "offsets": [ [ 736, 748 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013168" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 783, 786 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "narcotic" ], "offsets": [ [ 794, 802 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027415" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 851, 855 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "control" ], "offsets": [ [ 856, 863 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243148" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s4-t5", 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"Legislation" ], "offsets": [ [ 1032, 1043 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023252" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 1094, 1098 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "control" ], "offsets": [ [ 1099, 1106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243148" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "regulations" ], "offsets": [ [ 1107, 1118 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034982" }, { "db_name": "UMLS", "db_id": "C0220905" } ] }, { "id": "DerSchmerz.60100299.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "drug control" ], "offsets": [ [ 1094, 1106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013168" } ] } ]

[]

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DerSchmerz.60100302.eng.abstr

[ { "id": "DerSchmerz.60100302.eng.abstr-passage-0", "type": "abstract", "text": [ "Rules still valid today continue the tradition of state narcotics control , conceding therapeutic decisions to the physician , but at the same time allowing only restrictive use of narcotics . Legal control of medically indicated use of narcotics is burdened with conflicts . Recently , physicians have been given more scope in the use of strong opioids for pain therapy . Existing limits for a dose of opioids may be exceeded when necessary . However , there are still formal rules in the German Narcotics Drug Act ." ], "offsets": [ [ 0, 517 ] ] } ]

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[]

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DerSchmerz.60100312.eng.abstr

[ { "id": "DerSchmerz.60100312.eng.abstr-passage-0", "type": "abstract", "text": [ "In spite of the fact that the treatment of pain is highly developed , outpatient care of patients suffering from chronic pain is frequently insufficient . In particular general practitioners often refrain from prescribing the necessary pain therapy with opioids . Because of the contract regarding medical treatment , however , the patient has a legal claim to adequate pain treatment , if necessary by administration of opioids . The failure to meet this claim may not only give rise to a claim for damages towards the doctor , but even to a charge of bodily injury . In comparison , charging the physician with criminal behavior on the basis of the Narcotics Act is rather unlikely . Negligent or incorrect prescription of narcotic drugs does not constitute criminal behavior , but an administrative offence . Even this is hardly something which the physician has to fear . Any medically necessary administration of opioids is covered by the Narcotics Prescription Ordinance . The narcotics prescription form , however , remains indispensable for the safety in the use of narcotics . The doctor's prescription alone is obviously not sufficient to curb the considerable abuse of pharmaceutical products among the population . In the course of the introduction of EDP-readable narcotics prescription form as of 1 July 1995 , however , the issuing of this kind of prescription was further simplified . Handwritten particulars will soon be entirely a thing of the past . Now that the legal and administrative conditions for prescribing opioids have been consolidated , the main objective is to exhaust the possibilities of prescription for the benefit of patients suffering from pain in a better way . This is first and foremost , an organizational and technical task of the medical professional group . In particular , training and continuing education in the field of pain therapy must be further developed without delay ." ], "offsets": [ [ 0, 1922 ] ] } ]

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"umlsterm", "text": [ "objective" ], "offsets": [ [ 1576, 1585 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerSchmerz.60100312.eng.abstr-s13-t3", "type": "umlsterm", "text": [ "prescription" ], "offsets": [ [ 1621, 1633 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033080" } ] }, { "id": "DerSchmerz.60100312.eng.abstr-s13-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 1653, 1661 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.60100312.eng.abstr-s13-t5", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1677, 1681 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.60100312.eng.abstr-s14-t1", "type": "umlsterm", "text": [ "organizational" ], "offsets": [ [ 1732, 1746 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220885" } ] }, { "id": "DerSchmerz.60100312.eng.abstr-s15-t1", "type": "umlsterm", "text": [ "training" ], "offsets": [ [ 1818, 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[]

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"normalized": [] }, { "id": "DerSchmerz.60100312.eng.abstr-s10-r4-t2.1-t1.1", "type": "associated_with", "arg1_id": "DerSchmerz.60100312.eng.abstr-s15-t2", "arg2_id": "DerSchmerz.60100312.eng.abstr-s15-t1", "normalized": [] }, { "id": "DerSchmerz.60100312.eng.abstr-s10-r5-t1.1-t2.1", "type": "associated_with", "arg1_id": "DerSchmerz.60100312.eng.abstr-s15-t1", "arg2_id": "DerSchmerz.60100312.eng.abstr-s15-t2", "normalized": [] }, { "id": "DerSchmerz.60100312.eng.abstr-s13-r1-t1.1-t5.1", "type": "treats", "arg1_id": "DerSchmerz.60100312.eng.abstr-s15-t1", "arg2_id": "DerSchmerz.60100312.eng.abstr-s15-t5", "normalized": [] }, { "id": "DerSchmerz.60100312.eng.abstr-s13-r2-t3.1-t1.1", "type": "uses", "arg1_id": "DerSchmerz.60100312.eng.abstr-s15-t3", "arg2_id": "DerSchmerz.60100312.eng.abstr-s15-t1", "normalized": [] } ]

DerSchmerz.70110079.eng.abstr

[ { "id": "DerSchmerz.70110079.eng.abstr-passage-0", "type": "abstract", "text": [ "Craniomandibular disorders are suggested to be responsible for many cases of chronic pain of the head and face . The assessment of dysfunctional factors in diseases of chronic head and facial pain normally requires special knowledge and equipment for the diagnosis and therapy of stomatognathic dysfunction . However , the first signs can be evaluated rather well without using complete equipment , which is not always avaible in general practice . It is therefore important that general practitioners have a simple , time-efficient method of routine screening based on sufficient methods and tests . Thus , we would like to present a questionnaire consisting of ten points that cover the valid elements of complete stomatognathic assessment . Answering these questions reveals signs of dysfunctional components of craniomandibular disorders , which indicate a dysfunction diagnosis and even better , consultation with a specialist ." ], "offsets": [ [ 0, 933 ] ] } ]

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[]

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"associated_with", "arg1_id": "DerSchmerz.70110079.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.70110079.eng.abstr-s6-t3", "normalized": [] } ]

DerSchmerz.70110085.eng.abstr

[ { "id": "DerSchmerz.70110085.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : The present study examines the correlations between pain intensity , mood and pain-alleviating actions in pre-chronic low back pain patients . The three variables were obtained with the Ulm Pain Diary ( Ulmer Schmerztagebuch , UST ) . Methods : Thirty-eight patients with low back pain described pain intensity , effect of pain on mood and medication as well as other therapies over a 3-week period ( 21 days ) . The patients had a history of pain for between 6 weeks and 6 months . Clinical and orthopedic examinations revealed no relevant organic findings explaining the pain process . Results : Pain occurred on 18.1 ( of 21 ) days . Half of the patients ( n=19) used medication or took other actions against their pain . Correlations between the three variables demonstrated that all three were significantly related . Partial correlations showed in addition to a high correlation between pain intensity and mood , that the frequency of pain-relieving actions was far less related to pain intensity than to mood . The group that took actions against their pain had a higher level of pain intensity than the no-action group . Furthermore , the effect of pain on mood was significantly greater in this group than in the no-action group . Conclusion : The findings indicate that pain intensity , mood and actions against pain are highly correlated . When pain intensity is statistically controlled , the influence of mood on taking medication or other actions against pain becomes more pronounced . It can be concluded that self-initiated actions against pain depend much more on mood than on pain intensity in pre-chronic low back pain patients ." ], "offsets": [ [ 0, 1663 ] ] } ]

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DerSchmerz.70110091.eng.abstr

[ { "id": "DerSchmerz.70110091.eng.abstr-passage-0", "type": "abstract", "text": [ "There are only few publications about the effect of music therapy on pain relief . The intention of this prospective study is to demonstrate the influence of the Nordoff/Robbins method of active music therapy in a group of 12 patients with fibromyalgia , myofascial pain syndromes and polyarthritis on pain reduction , life quality and coping . The clinical parameters of each patient were related to the observations in the audio- and video-documented music therapy settings and to the self-reported changes in pain intensity and pain behaviour . There was a significant reduction of pain intensity and pain-related disability in the music group compared to a control group , but no change in the depression and anxiety score . The influence of music therapy could be even better demonstrated in the systematic analysis of the single cases by individual profiles . Active music therapy affects especially the communicative and emotional dimension of chronic pain . Psychophysiological and psychodynamic models are presented to explain the effectiveness of music therapy on pain reduction . Clinical studies on music therapy as well as on other \" art therapies \" should relate the analysis of clinical parameters to the descriptive-phenomenological documentation of the therapeutic process to demonstrate systematically the influence of music and art in the individual case ." ], "offsets": [ [ 0, 1375 ] ] } ]

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[]

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"arg1_id": "DerSchmerz.70110091.eng.abstr-s8-t4", "arg2_id": "DerSchmerz.70110091.eng.abstr-s8-t2", "normalized": [] } ]

DerSchmerz.70110101.eng.abstr

[ { "id": "DerSchmerz.70110101.eng.abstr-passage-0", "type": "abstract", "text": [ "In Middle Franconia , one of the larger Bavarian administrative division ( population 1994 : 1,657 , 101 ) , the number of patients suffering from cancer pain , chronic headache and chronic back pain is not known . Furthermore , there are no data on interdisciplinary organization of outpatient pain management ." ], "offsets": [ [ 0, 312 ] ] } ]

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[]

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DerSchmerz.70110108.eng.abstr

[ { "id": "DerSchmerz.70110108.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Extracorporeal shock waves ( ESW ) are being used increasingly frequently for the treatment of narrowly localized pain in the musculoskeletal system . Pain is normally associated with muscular dysfunction . Beginning with the observation that not only is the pain soothed by treatment with ESW , but that the muscular dysfunction itself is relieved , an attempt has been made to treat the impaired function in cases of infantile cerebral palsy with ESW . Method : In 35 children and young people with mainly spastic disturbances of movement , the bellies of those muscles producing the flexion contracture of the lower limb were each treated with 500 non-focused pulses of low-energy ESW . The focus ( focal pressure 10 MPA=0.06 mJ/mm ) of the shock waves itself was placed either within the coupling cushion of the therapy source ( Minilith , Storz Medical , CH-Kreuzlingen ) or obliquely outside the patient's body . In this way ESW could be dispersed throughout the muscles and the risk of undesirable effects was minimized . The energy used amounted to about 30% of the threshold value at which cellular damage from focused treatment with ESW had been observed in the endothelium of the human umbilical cord . Results : The degree of movement at the hip joint increased after one treatment by an average of 17 ° , at the knee joint by 12.3 ° and at the ankle joint by 7.1 ° , each increase being statistically significant . Muscular stiffness , spastic co-contractions , and myofascial viscoelasticity , as well as dyskinetic and ataxic symptoms , decreased . It appeared as if a systemic action had entered into the motor control . Together with an increase in general proprioception , there was an improvement in body image , in economy of movement and also in the limbs that had not been treated . A few patients showed euphoric reactions for about 2 days after treatment . No undesirable effects were observed during a follow-up of 12 months . The treatment was painless and is therefore suitable for children . The biomechanical improvement remained for several weeks and this time could be used for initiating an improved pattern of movement . Conclusion : ESW is suitable for use as an additional instrument for physiotherapeutic treatment of infantile cerebral palsy . The effective action of ESW on disturbed peripheral muscles has been discussed in terms of positive pressure and tensile wave forces and/or forces acting by cavitation . The results obtained in this pilot investigation showed particular a decrease in muscle stiffness . A controlled investigation with gait analysis and psychological control is to be undertaken ." ], "offsets": [ [ 0, 2659 ] ] } ]

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[]

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DerSchmerz.70110113.eng.abstr

[ { "id": "DerSchmerz.70110113.eng.abstr-passage-0", "type": "abstract", "text": [ "The authors demonstrate a way to treat meralgia paresthetica ( \" jeans disease \" ) with acupuncture . Two patients with therapy-resistant chronic pain and paresthesia of the lateral thigh became free of symptoms quickly and remained under acupuncture therapy . Gynecological , vertebral and urological factors must be excluded before any kind of symptomatic therapy is begun . The advantages and disadvantages of acupuncture are discussed ." ], "offsets": [ [ 0, 440 ] ] } ]

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[]

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DerSchmerz.70110116.eng.abstr

[ { "id": "DerSchmerz.70110116.eng.abstr-passage-0", "type": "abstract", "text": [ "A rheumatologist and a medical psychotherapist collaborate in offering periodically a cognitive behavioral treatment program for pain control for the patients of a rheumatological practice . The program consists of a biopsychosocial model of chronic pain , individualized relaxation training combining progressive muscle relaxation and some elements of autogenous training and meditation , several attention-related techniques and cognitive restructuring . From 1993 to 1995 , 50 patients took part in five training courses . The compliance of the patients was satisfactory and the drop-out rate low ( 8% ) . In a post hoc interview 4 weeks later and another 2 years after the end of the training most of the patients assessed the program as useful for reduction of pain , increase of activity and enhancement of mood . Psychotherapeutic experience in group therapy or special training for non-psychotherapeutic physicians with continuous supervision is necessary in order to conduct a qualified treatment program . Within medical primary care , rheumatologists can motivate their patients towards active pain management , which can help to prepare patients for further psychotherapy in cases with psychiatric disorders and/or severe psychosocial strains ." ], "offsets": [ [ 0, 1256 ] ] } ]

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], "offsets": [ [ 283, 291 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040607" }, { "db_name": "UMLS", "db_id": "C0220931" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "muscle" ], "offsets": [ [ 314, 320 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "relaxation" ], "offsets": [ [ 321, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035028" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "elements" ], "offsets": [ [ 341, 349 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013879" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "training" ], "offsets": [ [ 364, 372 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040607" }, { "db_name": "UMLS", "db_id": "C0220931" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "meditation" ], "offsets": [ [ 377, 387 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0150277" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "attention-related" ], "offsets": [ [ 398, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004268" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 416, 426 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "relaxation training" ], "offsets": [ [ 272, 291 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282333" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s2-t13", "type": "umlsterm", "text": [ "muscle relaxation" ], "offsets": [ [ 314, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026827" }, { "db_name": "UMLS", "db_id": "C0026836" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 480, 488 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "training" ], "offsets": [ [ 507, 515 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040607" }, { "db_name": "UMLS", "db_id": "C0220931" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "compliance" ], "offsets": [ [ 530, 540 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030680" }, { "db_name": "UMLS", "db_id": "C0009563" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 548, 556 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "interview" ], "offsets": [ [ 623, 632 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021822" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "training" ], "offsets": [ [ 688, 696 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040607" }, { "db_name": "UMLS", "db_id": "C0220931" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 709, 717 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "program" ], "offsets": [ [ 731, 738 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376691" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 766, 770 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "mood" ], "offsets": [ [ 813, 817 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026516" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 858, 865 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "training" ], "offsets": [ [ 877, 885 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040607" }, { "db_name": "UMLS", "db_id": "C0220931" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "physicians" ], "offsets": [ [ 912, 922 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "supervision" ], "offsets": [ [ 939, 950 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038842" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 996, 1005 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "program" ], "offsets": [ [ 1006, 1013 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376691" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s6-t7", "type": "umlsterm", "text": [ "group therapy" ], "offsets": [ [ 852, 865 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086374" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "care" ], "offsets": [ [ 1039, 1043 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0150499" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 1081, 1089 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1105, 1109 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 1149, 1157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s7-t5", "type": "umlsterm", "text": [ "psychotherapy" ], "offsets": [ [ 1170, 1183 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033968" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s7-t6", "type": "umlsterm", "text": [ "disorders" ], "offsets": [ [ 1210, 1219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s7-t7", "type": "umlsterm", "text": [ "strains" ], "offsets": [ [ 1247, 1254 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0080194" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s7-t8", "type": "umlsterm", "text": [ "primary care" ], "offsets": [ [ 1031, 1043 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033137" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s7-t9", "type": "umlsterm", "text": [ "pain management" ], "offsets": [ [ 1105, 1120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002766" } ] }, { "id": "DerSchmerz.70110116.eng.abstr-s7-t10", "type": "umlsterm", "text": [ "psychiatric disorders" ], "offsets": [ [ 1198, 1219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004936" } ] } ]

[]

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DerSchmerz.70110120.eng.abstr

[ { "id": "DerSchmerz.70110120.eng.abstr-passage-0", "type": "abstract", "text": [ "The present paper is one in a series of publications reviewing German instruments for the psychological assessment of pain . Part X deals with pain measurement of acute and chronic pain in infants and children . German assessment instruments of pediatric pain together with frequently used instruments of American origin are examined and described . The survey contains self-report and behavioral pain measures . Multidimensional pain interviews for both children and parents , diaries and rating scales , as well as observation measures especially for infants , are examined . Since the selection of pain-assessment instruments is dependent on the age and cognitive level of the children , for each instrument a minimum age limit is given . In cases in which quantitative indices of reliability , validity and objectivity are still needed , the evaluation is based on qualitative quotations ." ], "offsets": [ [ 0, 893 ] ] } ]

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DerSchmerz.70110148.eng.abstr

[ { "id": "DerSchmerz.70110148.eng.abstr-passage-0", "type": "abstract", "text": [ "Recurrent abdominal pain ( RAP ) is one of the most common pain syndromes in childhood , with prevalence rates ranging from 10 to 20% in all school-age children . In nearly 50% the complaints persist over many years of their life-span to adolescence or adulthood . Although the empirical findings have increased in the last decade , our knowledge about the etiology , pathogenesis , and pathophysiology is still very limited . Current approaches suggest that we understand recurrent pain syndromes as a complex and multidimensional disturbance ( biopsychosocial paradigm ) . In this respect there is strong evidence for the major importance of psychosocial causes ( daily hassles , specific life events ) , psychopathological factors ( anxiety , depression , somatization disorder ) , and social environmental influences ( mother's psychopathology , social modelling , reinforcement ) in the pathogenesis of functional abdominal pain . The noticeable correlation with other pain syndromes and functional disturbances indicates that recurrent pain may possibly be a manifestation of a basic somatization disorder . The unfavourable long-term prognosis supports the need for early and specific interventions . Psychological treatment requires a medical examination to exclude organic origins . Some of these invasive diagnostic procedures can be very difficult , expensive and distressing for the child . Behavioural medicine is based upon having an extensive family history and symptom analysis . The psychological interventions applied in clinical practice include prophylaxis , reduction of pain symptoms and environmental modification . In recent years there has been an increasing trend to create more complex and multidimensional behavioural treatment programs for children . Although preliminary data on the use of these behavioural medicine programs have shown some promise , further investigations are needed to examine the applicability and effectiveness of specific interventions in the treatment of abdominal pain symptoms ." ], "offsets": [ [ 0, 2034 ] ] } ]

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[]

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DerSchmerz.70110165.eng.abstr

[ { "id": "DerSchmerz.70110165.eng.abstr-passage-0", "type": "abstract", "text": [ "Methods : Long-term outcome in terms of well-being , depression and ability to cope was evaluated by means of a mailed questionnaire up to 5 years after participation in an integrated group treatment program for chronic musculoskeletal pain ( mostly back pain ) . Sixty-one completed questionnaires were available for analysis , representing 69% of all 89 participants ." ], "offsets": [ [ 0, 370 ] ] } ]

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[]

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DerSchmerz.70110172.eng.abstr

[ { "id": "DerSchmerz.70110172.eng.abstr-passage-0", "type": "abstract", "text": [ "In a prospective study 30 patients suffering from a lumbar disc-prolaps and typical neurological symptoms were examined with regard to the predictors of the outcome 15 months postoperatively . Alongside the clinical examination and the raising of illness-anamnesis the Giessen pain questionaire ( Giessener Beschwerde-Bogen ) , the Giessen-Test , the Freiburg Personality Inventory ( Freiburger Persoenlichkeits-Inventar ) , the Mainz pain questionaire und a pain scale were used ." ], "offsets": [ [ 0, 481 ] ] } ]

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[]

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DerSchmerz.70110180.eng.abstr

[ { "id": "DerSchmerz.70110180.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Because of their frequency and consequences sciatica remains a demanding clinical entity with significant social and economical impact . There is a high demand on therapeutic modalities , using folk medicine methods in the treatment of orthopaedic diseases . No data is available on the usefullness of methods like natural herbs in combination with acupuncture . Aim of our study was to present data on the effect of acupuncture and cytokineinhibiting natural herbs in sciatic pain . We compared these results with nerve root infiltration by local anaesthetics and corticosteroids in our orthopaedic outpatient clinic . Materials and Results : 278 patients with chronic pain for at least 3 months were observed . All three therapeutical modalities showed improvement of pain scores . Best results were gained with steroid injection ( n=26; 66% pain reduction ) , acupuncture in combination with herbs improved the pain in average of 62% ( n=230), whereas injection with local anaesthetic had a pain reduction of 48% ( n=22). Sole Mepivacain-HCl treatment had significant less pain reduction compared to the other treatment modalities . Conclusion : According to our results acupuncture in combination with herbs and steroid nerve blocks appear to be an effective and thus recommendable conservative therapy in cases of sciatic pain . Taking into account that patients increasingly prefer ethnomedical modalities of treatment our study gains importance for practising orthopaedists ." ], "offsets": [ [ 0, 1497 ] ] } ]

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"C0025664" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 238, 247 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 263, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "folk medicine" ], "offsets": [ [ 209, 222 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016419" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 317, 324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110180.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "herbs" ], "offsets": [ [ 338, 343 ] ], "normalized": [ { "db_name": "UMLS", 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[]

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DerSchmerz.70110185.eng.abstr

[ { "id": "DerSchmerz.70110185.eng.abstr-passage-0", "type": "abstract", "text": [ "Continuous epidural infusion of bupivacaine with the opioid fentanyl represents an effective analgesic method in the therapy of strong postoperative pain after major surgery . Preparation of the required infusion solution in syringes with a volume of 50 ml immediately prior to administration is routinely performed by nursing staff in Germany . The effort required for the preparation is associated with logistical and pharmaceutical difficulties . The preparation of a mixture of bupivacaine hydrochloride 0.06% and fentanyl 0.0002% in 250 ml infusion bags at the pharmacy of the University Hospital Mainz is described . To determine the physicochemical stability , the concentration of bupivacaine-HCl and fentanyl was assessed using HPLC over a period of 32 days ; in addition the pH values were determined . After 32 days 95% of the bupivacaine hydrochloride and fentanyl baseline values were recorded . The pH baseline value had decreased from 5.48-5.52 to 0.5-0.7 units . The measured values confirm the physicochemical stability of the mixture of bupivacaine hydrochloride 0.06% and fentanyl 0.0002% over a period of 32 days . The infusion bag can be stored for 4 weeks at room temperature ." ], "offsets": [ [ 0, 1199 ] ] } ]

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[]

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DerSchmerz.70110213.eng.abstr

[ { "id": "DerSchmerz.70110213.eng.abstr-passage-0", "type": "abstract", "text": [ "Both preclinical and clinical evidence support the usefulness of antidepressants in chronic pain treatment . Monoamine uptake inhibitors influence the neurotransmissions of noradrenaline ( NA ) and/or serotonin ( 5-HT ) ; their effect on nociception is thought to take place predominantly within the spinal cord . Antidepressant drugs seem to differ in their properties as analgesics and as thymoleptics . The present work is aimed at correlating the special mechanism of action of antidepressants in diminishing nocicepetion with the pharmacological profile of these drugs in clinical pain treatment . From a preclinical , experimental point of view , it can be expected , that mixed type uptake blockers should be superior to selective NA or 5-HT uptake inhibitors . The analgesic profile of antidepressants was established by a metaanalysis of clinical trials on the effect of these drugs , given alone or in combination with other analgetics , in chronic pain syndromes . 57 Clinical trials were separated into 5 groups according to their scientific quality : [ 1 ] placebo-controlled double-blind studies with high power ; [ 2 ] placebo-controlled double-blind studies with low power ; [ 3-4 ] open controlled studies or studies with historical controls ; [ 5 ] case reports . A study was positive if the tested antidepressant was more effective than placebo or the compared drug or seemed beneficial with respect to the interval of its previous absence . The most effective antidepressants in chronic pain treatment only included unselective monoamine reuptake inhibitors in the following rank order : amitriptyline > clomipramine > = desipramine > = imipramine > = doxepin . A statement about the appropriate dosage of these drugs in chronic pain treatment , however , must wait for properly conducted dose finding studies which include the measurement of plasma concentrations ." ], "offsets": [ [ 0, 1886 ] ] } ]

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[]

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DerSchmerz.70110233.eng.abstr

[ { "id": "DerSchmerz.70110233.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Clinical observations of patients under oral opioid treatment suggest that the initially appearing central side effects such as sedation , dizziness or drowsiness decrease after a few weeks of treatment . However , it is still unclear whether long-term treatment with opioids impairs complex psychomotor functions such as driving a car ." ], "offsets": [ [ 0, 352 ] ] } ]

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[]

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"DerSchmerz.70110233.eng.abstr-s2-t5", "normalized": [] }, { "id": "DerSchmerz.70110233.eng.abstr-s2-r36-t1.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110233.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.70110233.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerSchmerz.70110233.eng.abstr-s2-r37-t4.1-t6.1", "type": "result_of", "arg1_id": "DerSchmerz.70110233.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.70110233.eng.abstr-s2-t6", "normalized": [] }, { "id": "DerSchmerz.70110233.eng.abstr-s2-r38-t6.1-t3.1", "type": "result_of", "arg1_id": "DerSchmerz.70110233.eng.abstr-s2-t6", "arg2_id": "DerSchmerz.70110233.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.70110233.eng.abstr-s2-r39-t1.1-t4.1", "type": "affects", "arg1_id": "DerSchmerz.70110233.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.70110233.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerSchmerz.70110233.eng.abstr-s2-r40-t2.1-t1.1", "type": "diagnoses", "arg1_id": "DerSchmerz.70110233.eng.abstr-s2-t2", "arg2_id": "DerSchmerz.70110233.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.70110233.eng.abstr-s2-r41-t1.1-t4.1", "type": "causes", "arg1_id": "DerSchmerz.70110233.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.70110233.eng.abstr-s2-t4", "normalized": [] } ]

DerSchmerz.70110241.eng.abstr

[ { "id": "DerSchmerz.70110241.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : Postoperative nausea and vomiting remains an important problem . Many risk factors have been identified ; however , the importance of postoperative analgesic technique and patient expectation remain poorly defined ." ], "offsets": [ [ 0, 225 ] ] } ]

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[]

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DerSchmerz.70110254.eng.abstr

[ { "id": "DerSchmerz.70110254.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : Two methods for the assessment of change are evaluated : ( 1 ) subjects ' ratings of the outcome taken after termination of the treatment , and ( 2 ) comparison of test scores taken before the beginning and after termination of the treatment ." ], "offsets": [ [ 0, 253 ] ] } ]

[ { "id": "DerSchmerz.70110254.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 14, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 30, 40 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 138, 147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "test" ], "offsets": [ [ 174, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0076174" } ] }, { "id": "DerSchmerz.70110254.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 242, 251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

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DerSchmerz.70110263.eng.abstr

[ { "id": "DerSchmerz.70110263.eng.abstr-passage-0", "type": "abstract", "text": [ "Despite excellent technical means of imaging the posterior fossa by magnetic resonance imaging ( MRI ) , some infratentorial space-occupying processes still remain undiscovered , especially if they present only slight symptoms or imitate typical different diseases ." ], "offsets": [ [ 0, 266 ] ] } ]

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[]

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DerSchmerz.70110305.eng.abstr

[ { "id": "DerSchmerz.70110305.eng.abstr-passage-0", "type": "abstract", "text": [ "This article reviews the empirical research which has examined the relationships among chronic pain and cognitions like attributions , coping , beliefs , expectations and problem solving . Methods for the examination of pain cognitions and coping strategies are reviewed . Current research which shows the significance of cognitions and coping for the chronification of pain states is reported . These findings are critically discussed . Other methods for future research are presented ." ], "offsets": [ [ 0, 487 ] ] } ]

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[]

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DerSchmerz.70110314.eng.abstr

[ { "id": "DerSchmerz.70110314.eng.abstr-passage-0", "type": "abstract", "text": [ "Chronic pain has a variety of causes . Therefore patients with chronic pain should be treated in an interdisciplinary way . From a psychological point of view a cognitive-behavioral approach is preferred . This includes training for coping with pain as well as the added option of a comprehensive psychotherapy . This form of treatment seems to be indicated in most cases , but it is not suitable if the patient does not agree with the procedure , preferring instead a special kind of therapy which is not cognitive-behavioral . On the other hand a psychological treatment is not indicated if the therapist is not prepared to cooperate with other therapists in an interdisciplinary fashion ." ], "offsets": [ [ 0, 691 ] ] } ]

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[]

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DerSchmerz.70110322.eng.abstr

[ { "id": "DerSchmerz.70110322.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Headache is thought to be generated by nociceptive processes within the meninges , followed by activation of trigeminal neurons within the brainstem . The noxious stimuli initially involved in these nociceptive processes are unknown . A preparation was developed in the barbiturate-anesthetized rat , in which the activation of trigeminal brain stem neurons by selective local stimulation of the dura mater could be observed ." ], "offsets": [ [ 0, 441 ] ] } ]

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[]

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DerSchmerz.70110328.eng.abstr

[ { "id": "DerSchmerz.70110328.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : \" Pain under Discussion \" aims at the education of patients with chronic headache and back pain by applying a standardized manual with detailed instructions for seven sessions in a group setting . Apart from encouraging a reconceptualization of the patients ' pain experience with reference to a bio-psycho-social model , the program provides information about the vicious circle of pain , avoidance and demoralization and relies heavily on behavioral assumptions about the process of chronicity . Patients are offered participation in progressive relaxation according to Jacobson , they learn to engage in pleasant activities , and are instructed to more and more maintain an upright body position during various activities of every day life . The study evaluates the outcome of the training . Moreover , as an algorithm for grading pain patients according to their level of chronicity has recently been developed by Gerbershagen , we use this algorithm in order to investigate the relationship between the outcome of treatment and the assigned level of chronicity . In addition , we test the assumption that a higher level of chronicity is related to a lower level of psychological functioning pre treatment ." ], "offsets": [ [ 0, 1221 ] ] } ]

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[]

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"DerSchmerz.70110328.eng.abstr-s5-t5", "arg2_id": "DerSchmerz.70110328.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerSchmerz.70110328.eng.abstr-s5-r4-t3.1-t4.1", "type": "uses", "arg1_id": "DerSchmerz.70110328.eng.abstr-s5-t3", "arg2_id": "DerSchmerz.70110328.eng.abstr-s5-t4", "normalized": [] }, { "id": "DerSchmerz.70110328.eng.abstr-s5-r5-t3.1-t1.1", "type": "uses", "arg1_id": "DerSchmerz.70110328.eng.abstr-s5-t3", "arg2_id": "DerSchmerz.70110328.eng.abstr-s6-t1", "normalized": [] } ]

DerSchmerz.70110339.eng.abstr

[ { "id": "DerSchmerz.70110339.eng.abstr-passage-0", "type": "abstract", "text": [ "2-adrenergic agonists , mimicking the action of the inhibitory transmitter norepinephrine , cause antinociception due to postsynaptic inhibition of spinothalamic projection neurons , presynaptic inhibition at the central nervous system termination of primary sensory nerves , presynaptic inhibition of brainstem noradrenergic neurons and a generalized decrease in central nervous system sympathetic efferent activity . There is a mutual potentiation of antinociceptive effects of clonidine and morphine . Clonidine is used in chronic pain states for treatment of neuropathic , neuralgic and deafferentiating pain . Based on a meta-analysis of the studies published in the years 1996-1996 , the therapeutic efficacy of systematically administered clonidine was evaluated in chronic pain states . Out of 403 screened published studies , only 9 fulfilled the selection criteria . Besides three case reports with successful clonidine treatment , four placebo-controlled studies could be analyzed treating the following chronic pain states : chest pain despite normal coronary angiograms ; painful diabetic neuropathy ; postherpetic neuralgia ; hyperalgia in patients with sympathetically maintained pain and chronic low back pain . Although three studies demonstrated statistically significant improvement in pain scores , the improvement in pain relief in these cases was slight . Long-term treatment was successful in a few responders over a period of 17 months . Hyperalgesia caused by sympathetically maintained pain was relieved by topical ( transdermal ) application of clonidine . Based on this evaluation a grade C recommendation is derived , which relates to responders . Successful treatment is expected only in pain states with increased sympathetic nervous system activity . Therefore , in chronic pain , treatment with systemic clonidine is of no significant value ." ], "offsets": [ [ 0, 1875 ] ] } ]

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"clonidine" ], "offsets": [ [ 1837, 1846 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009014" } ] }, { "id": "DerSchmerz.70110339.eng.abstr-s12-t4", "type": "umlsterm", "text": [ "value" ], "offsets": [ [ 1868, 1873 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] } ]

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DerSchmerz.70110345.eng.abstr

[ { "id": "DerSchmerz.70110345.eng.abstr-passage-0", "type": "abstract", "text": [ "Objective . To provide a brief review of the current state of topical treatment with capsaicin or acetylsalicylic acid ( ASA ) for therapy of chronic pain syndromes ." ], "offsets": [ [ 0, 166 ] ] } ]

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[]

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DerSchmerz.70110378.eng.abstr

[ { "id": "DerSchmerz.70110378.eng.abstr-passage-0", "type": "abstract", "text": [ "This paper reviews instruments in German language for the psychological assessment and classification of pain . Usually chronic pain syndromes are classified within the International Classification of Diseases ( ICD ) . Instead of the psychiatric chapter of the ICD , it is possible to use the Diagnostic and Statistical Manual of Mental Disorders ( DSM ) . The proposed classification system of the International Association of the Study of Pain ( IASP ) is based on a multiaxial solution . The numerous ways to classify chronic pain include many problems and limits , especially in the case of an interdisciplinary assessment . They provide no specific system for classifying pain syndromes . They are impractical to handle and restrict classifying pain as either somatogenic or psychogenic . It is not possible to describe both sides in one diagnosis without loss of information . As a result of this situation , a task force of the German Chapter of the International Association for the Study of Pain developed a Multiaxial Classification of Pain ( Multiaxiale Schmerzklassifikation ; MASK ) as an advanced system of pain assessment and an alternative to the common classification systems . MASK embraces a somatic ( MASK-S ) and a psychological ( MASK-P ) part. Both parts constitute an ' interdisciplinary diagnosis ' . MASK-S enables classifying a pain syndrome using hierarchical levels , with progredient specific degrees of differentiation . In addition there are 6 axes to describe pain syndromes qualitatively and quantitatively ( e.g. localization , quality ) . The psychosocial part ( MASK-P ) embraces 5 main levels ( 1. behavioral , 2. emotional , 3. cognitive , 4. stress-related , 5. habitual personal factors ) and 2 additional levels ( 6. functional coherence , 7. ICD/DSM-diagnosis additional ) . The MASK-P part of the diagnosis is composed of graduation on these levels . Differential axis of the pain syndromes are described phenomenologically and specifically . MASK provides the possibility of establishing an integrative , interdisciplinary diagnosis ." ], "offsets": [ [ 0, 2080 ] ] } ]

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[]

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"type": "associated_with", "arg1_id": "DerSchmerz.70110378.eng.abstr-s16-t1", "arg2_id": "DerSchmerz.70110378.eng.abstr-s15-t4", "normalized": [] }, { "id": "DerSchmerz.70110378.eng.abstr-s15-r10-t4.1-t3.1", "type": "degree_of", "arg1_id": "DerSchmerz.70110378.eng.abstr-s15-t4", "arg2_id": "DerSchmerz.70110378.eng.abstr-s15-t3", "normalized": [] }, { "id": "DerSchmerz.70110378.eng.abstr-s15-r11-t1.1-t4.1", "type": "location_of", "arg1_id": "DerSchmerz.70110378.eng.abstr-s16-t1", "arg2_id": "DerSchmerz.70110378.eng.abstr-s15-t4", "normalized": [] }, { "id": "DerSchmerz.70110378.eng.abstr-s15-r12-t1.1-t3.1", "type": "associated_with", "arg1_id": "DerSchmerz.70110378.eng.abstr-s16-t1", "arg2_id": "DerSchmerz.70110378.eng.abstr-s15-t3", "normalized": [] }, { "id": "DerSchmerz.70110378.eng.abstr-s15-r13-t3.1-t4.1", "type": "degree_of", "arg1_id": "DerSchmerz.70110378.eng.abstr-s15-t3", "arg2_id": "DerSchmerz.70110378.eng.abstr-s15-t4", "normalized": [] }, { "id": "DerSchmerz.70110378.eng.abstr-s16-r1-t2.1-t1.1", "type": "uses", "arg1_id": "DerSchmerz.70110378.eng.abstr-s16-t2", "arg2_id": "DerSchmerz.70110378.eng.abstr-s16-t1", "normalized": [] } ]

DerSchmerz.70110387.eng.abstr

[ { "id": "DerSchmerz.70110387.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : In recent years most industrialized nations have been confronted with a dramatic increase in cases dealing with back pain which , because of the associated costs , has put a strain on health care systems . Because of the tremendous costs caused by patients with chronic illnesses , there is a common interest in identifying determinants responsible for the pain becoming chronic . According to the fear-avoidance model , chronic back pain is the cause of specific patient beliefs according to their perception and appraisal of back pain and their assumptions about the connection between pain and work activities . These fear-avoidance beliefs are assumed as the main cognitive factors of adapting to chronic invalidism . In this study a German version of a self-reporting instrument that assesses fear-avoidance beliefs ( FABQ , Waddell et al. 1993 ) is presented ." ], "offsets": [ [ 0, 881 ] ] } ]

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"db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 603, 607 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "work" ], "offsets": [ [ 612, 616 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "back pain" ], "offsets": [ [ 444, 453 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004604" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s3-t11", "type": "umlsterm", "text": [ "back pain" ], "offsets": [ [ 542, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004604" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "beliefs" ], "offsets": [ [ 651, 658 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004951" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "instrument" ], "offsets": [ [ 788, 798 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243113" } ] }, { "id": "DerSchmerz.70110387.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "beliefs" ], "offsets": [ [ 828, 835 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004951" } ] } ]

[]

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DerSchmerz.70110396.eng.abstr

[ { "id": "DerSchmerz.70110396.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : A pilot study was conducted to provide an indication of the power density ( PD ) dependent analgesic effect of ultrasound ( US ) under serial application in patients with low back pain ." ], "offsets": [ [ 0, 201 ] ] } ]

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[]

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DerSchmerz.70110411.eng.abstr

[ { "id": "DerSchmerz.70110411.eng.abstr-passage-0", "type": "abstract", "text": [ "Anticonvulsive drugs provide good analgesic effect in the treatment of chronic neuropathic pain syndromes as well as in certain types of headache . Moreover these drugs may also be considered helpful for cases of non-neuropathic pain , especially if non-opioid analgesics are not effective ." ], "offsets": [ [ 0, 291 ] ] } ]

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[]

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{ "id": "DerSchmerz.70110411.eng.abstr-s1-r26-t7.1-t8.1", "type": "diagnoses", "arg1_id": "DerSchmerz.70110411.eng.abstr-s1-t7", "arg2_id": "DerSchmerz.70110411.eng.abstr-s1-t8", "normalized": [] }, { "id": "DerSchmerz.70110411.eng.abstr-s2-r1-t1.1-t2.1", "type": "treats", "arg1_id": "DerSchmerz.70110411.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.70110411.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.70110411.eng.abstr-s2-r2-t3.1-t2.1", "type": "treats", "arg1_id": "DerSchmerz.70110411.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.70110411.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.70110411.eng.abstr-s2-r3-t4.1-t2.1", "type": "treats", "arg1_id": "DerSchmerz.70110411.eng.abstr-s2-t4", "arg2_id": "DerSchmerz.70110411.eng.abstr-s2-t2", "normalized": [] } ]

DerSchmerz.80120001.eng.abstr

[ { "id": "DerSchmerz.80120001.eng.abstr-passage-0", "type": "abstract", "text": [ "The Dutch Supreme Court ruled that in exceptional instances , physician-assisted suicide might be justifiable for patients with unbearable mental suffering but no physical illness . A recent report shows that explicit requests for physician-assisted suicide are not uncommon in psychiatric practice in the Netherlands . Some of those requests were granted and their medical background was described . Psychiatric consultation for medical patients who request physician-assisted suicide is relatively rare ." ], "offsets": [ [ 0, 506 ] ] } ]

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[]

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DerSchmerz.80120008.eng.abstr

[ { "id": "DerSchmerz.80120008.eng.abstr-passage-0", "type": "abstract", "text": [ "Widespread pain syndromes of the musculoskeletal system present to general practitionas , internists , neurologists and orthopedic surgeons every day . The syndromes may result both from organic diseases ( inflammatory joint diseases , rheumatic manifestations of organ diseases ) as well as dysfunctional syndromes , the latter including mainly biomechanically induced syndromes and fibromyalgia . The approach is predominantly clinically oriented and requires laboratory means or technical procedures only in a limited extend . The duration of history , the recognition of synovitis and of myofascial trigger points or of integumental tender points allow in most patients to achieve appropriate diagnostic criteria ." ], "offsets": [ [ 0, 718 ] ] } ]

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[]

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DerSchmerz.80120012.eng.abstr

[ { "id": "DerSchmerz.80120012.eng.abstr-passage-0", "type": "abstract", "text": [ "Commonly pain has been seen as a warning sign reacting to a source of pain . This process displays the wisdom of the body and its ability to function well . But this concept cannot necessarily be upheld when , due to illness , integrity of the body can be neither the presupposition nor the goal of treatment . The ethical question is not to decide which perspective ( pain as a vital sign or pain as catastrophe ) is the dominant one . Medical ethics must acknowledge pain as a process of human destruction , and it must interpret the treatment of pain as an endeavour which makes life possible again , or strengthens its remaining elements . When pain goes beyond the resources of the human being to form his/her life , the border between meaningful and meaningless pain is crossed . A case from an obstetrical ward is used to demonstrate three central principles of the treatment of pain : ( 1 ) Understanding the pain as the end of all interests , as making life a burden or as evacuating the ego . 2. Respect of the autonomy of the patient by informing him/her about the experiences which he/she gets rid of during analgesia , or by establishing the possibilities that PCA or time-contingent medication offer . 3. The multidimensional therapy of pain : i.e. all groups of caregivers must be involved , because it is not important to know which perspective is the best , but that no single perspective can stand alone . These principles must be taken into account even when the possibilities of effective pain relief are exhausted . Sometimes the debate on the practice of euthanasia seems to replace the medical goal of honest treatment of the patient's pain ." ], "offsets": [ [ 0, 1665 ] ] } ]

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"DerSchmerz.80120012.eng.abstr-s10-t1", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1509, 1513 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120012.eng.abstr-s11-t1", "type": "umlsterm", "text": [ "euthanasia" ], "offsets": [ [ 1577, 1587 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015187" } ] }, { "id": "DerSchmerz.80120012.eng.abstr-s11-t2", "type": "umlsterm", "text": [ "goal" ], "offsets": [ [ 1617, 1621 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "DerSchmerz.80120012.eng.abstr-s11-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 1632, 1641 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120012.eng.abstr-s11-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 1659, 1663 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] } ]

[]

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DerSchmerz.80120019.eng.abstr

[ { "id": "DerSchmerz.80120019.eng.abstr-passage-0", "type": "abstract", "text": [ "Tramadol , an analgesic with mean potency one tenth that of morphine is used regularely for the treatment of chronic and postoperative pain . Previous reports have indicated that tramadol may induce seizure activity when given together with a selective serotonine reuptake inhibitor ( SSRI ) . Therefore , its major mode of action may be questioned which purportedly is due to binding with the opioid receptor and partly due to the inhibition of monoamine reuptake ." ], "offsets": [ [ 0, 466 ] ] } ]

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[]

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DerSchmerz.80120030.eng.abstr

[ { "id": "DerSchmerz.80120030.eng.abstr-passage-0", "type": "abstract", "text": [ "The wide variety of therapeutic effects make neuroleptics potent drugs in the treatment of pain . Until now there has been no proof of their analgesic potency ; in spite of this fact , neuroleptics are used to treat chronic pain states on the assumption that they do have analgesic potency . A metaanalysis was performed and 48 publications reviewed . Thirty-four , the majority of the studies , are case reports , retrospective analyses or non-randomised cohort studies . Most of these reports attest to a positive effect . However , only ten out of fifteen studies with a higher statistical study power describe a possible analgesic effect . None of the studies could differentiate between the effects of analgesia and sedation of the drugs used . The metaanalysis provides no evidence of intrinsic analgesic properties of neuroleptics for their use as adjuvant analgesics ." ], "offsets": [ [ 0, 876 ] ] } ]

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[]

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DerSchmerz.80120105.eng.abstr

[ { "id": "DerSchmerz.80120105.eng.abstr-passage-0", "type": "abstract", "text": [ "Aim : This review article focuses on a possible pain-alleviating effect of shock-wave application in persistent lateral epicondylopathy of the elbow and compares the effects with data on other non-operative and operative procedures ." ], "offsets": [ [ 0, 233 ] ] } ]

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[]

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DerSchmerz.80120112.eng.abstr

[ { "id": "DerSchmerz.80120112.eng.abstr-passage-0", "type": "abstract", "text": [ "Prostaglandin synthesis inhibitors and parasympatholytic drugs are often used as analgetics in the case of renal colic . This paper analyzes how and whether these drug effects are important for the analgetic therapy . In an animal and in a human model with acutely obstructed kidneys we found that intravenous application of Indometacine and dipyrone significantly reduces renal pelvic pressure . The parasympatholytic drug hyoscine butylbromide did not produce any change of upper urinary tract dynamics . Inhibitors of prostaglandin synthesis thus effect pressure reduction in the renal pelvis , which is necessary for analgetic therapy . In contrast , hyoscine butylbromide does not have any influence on the acute upper urinary tract obstruction ; consequently its usefulness in the treatment of renal colic is rather doubtful ." ], "offsets": [ [ 0, 832 ] ] } ]

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"UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "drug effects" ], "offsets": [ [ 163, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0728866" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "animal" ], "offsets": [ [ 224, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "human" ], "offsets": [ [ 240, 245 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "kidneys" ], "offsets": [ [ 276, 283 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022646" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "dipyrone" ], "offsets": [ [ 342, 350 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012586" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 386, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "parasympatholytic" ], "offsets": [ [ 401, 418 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030511" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 419, 423 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "hyoscine" ], "offsets": [ [ 424, 432 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036442" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "butylbromide" ], "offsets": [ [ 433, 445 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0626371" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "butylbromide" ], "offsets": [ [ 433, 445 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006222" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "parasympatholytic drug" ], "offsets": [ [ 401, 423 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030511" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "urinary tract" ], "offsets": [ [ 482, 495 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042027" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Inhibitors" ], "offsets": [ [ 507, 517 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243077" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "prostaglandin" ], "offsets": [ [ 521, 534 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033554" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s5-t3", "type": 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], "offsets": [ [ 644, 652 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0110625" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "hyoscine" ], "offsets": [ [ 655, 663 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036442" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "butylbromide" ], "offsets": [ [ 664, 676 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0626371" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "butylbromide" ], "offsets": [ [ 664, 676 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006222" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 787, 796 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120112.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "colic" ], "offsets": [ [ 806, 811 ] 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[]

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DerSchmerz.80120118.eng.abstr

[ { "id": "DerSchmerz.80120118.eng.abstr-passage-0", "type": "abstract", "text": [ "The study consists of a prospective randomized controlled clinical trial of patients undergoing laparoscopic cholecystectomy . Besides medical and sociodemographic data , two personality factors - self-efficacy and locus of control - were found to predict postoperative pain . Self-efficacy describes the expectations of a person to successfully execute the behavior required to produce behavioral outcomes . Locus of control , in the extreme case , is a personality factor which is represented by an internal orientation in which the individual believes that rewards are brought about by his own action , versus an external orientation , in which the individual believes that rewards are the result of powerful others or chance factors and fate . We postulate that the two personality factors correlate with postoperative parameters of pain and that there are also multiple correlations between them ." ], "offsets": [ [ 0, 902 ] ] } ]

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[]

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DerSchmerz.80120130.eng.abstr

[ { "id": "DerSchmerz.80120130.eng.abstr-passage-0", "type": "abstract", "text": [ "Monodisciplinary orthopaedic pain therapy no longer measures up to international standards . In cases of chronic back pain , in particular , there is such a gulf between the clinical findings and the patient's subjective assessment that the symptoms cannot be attributed solely to so-called degenerative changes . Back pain patients are in great danger of becoming fixated on somatic symptoms due to an excess of diagnostic procedures or incorrect diagnoses , of being treated purely somatically on the basis of associated findings , and of suffering irreversible damage from invasive management of such findings . Despite the wealth of empirical evidence , it remains difficult to expand the everyday concept of illness and its causes to include not only physical and biological factors but also social and emotional disturbances . Particularly physicians with a purely biological concept of pain have not learned to take note of affective relational factors and incorporate them into their diagnostic assessment . The decision to undertake invasive diagnostic or therapeutic procedures then frequently represents the doctor's reaction to feelings of irritation or helplessness . If this situation is to change , an interdisciplinary concept of pain must be made a part of medical training , and scientific findings must be presented in such a way that they can be integrated into routine daily practice ." ], "offsets": [ [ 0, 1406 ] ] } ]

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"db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 523, 531 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "findings" ], "offsets": [ [ 604, 612 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "Back pain" ], "offsets": [ [ 314, 323 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004604" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "causes" ], "offsets": [ [ 729, 735 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "biological factors" ], "offsets": [ [ 769, 787 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005515" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "emotional disturbances" ], "offsets": [ [ 808, 830 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013985" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "physicians" ], "offsets": [ [ 846, 856 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 893, 897 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 992, 1002 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 1003, 1013 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "diagnostic" ], "offsets": [ [ 1051, 1061 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 1065, 1076 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 1077, 1087 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "feelings" ], "offsets": [ [ 1140, 1148 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015749" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "therapeutic procedures" ], "offsets": [ [ 1065, 1087 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" } ] }, { "id": "DerSchmerz.80120130.eng.abstr-s7-t1", "type": 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[]

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DerSchmerz.80120136.eng.abstr

[ { "id": "DerSchmerz.80120136.eng.abstr-passage-0", "type": "abstract", "text": [ "Disregarding pain resulting from vitamin deficiency , an analgesic effect seems to be exerted only by vitamin B1 ( thiamine ) , vitamin B6 ( pyridoxines ) , and vitamin B12 ( cobalamine ) , particularly when the three are given in combination . The analgesic effect is attributed to an increased availability and/or effectiveness of noradrenaline and 5-hydroxytryptamine acting as inhibitory transmitters in the nociceptive system ." ], "offsets": [ [ 0, 432 ] ] } ]

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[]

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DerSchmerz.80120142.eng.abstr

[ { "id": "DerSchmerz.80120142.eng.abstr-passage-0", "type": "abstract", "text": [ "Weak opioids have a maximal dose ( ceiling effect ) , and their distribution and prescription is not controlled by German narcotic laws . In a literature search ( Medline 1963- 1995 ) and our own literature database on pain treatment , 58 publications were identified . These reported about 130 comparisons of weak opioids with different analgesics . The statistical parameters of a meta-analysis were not calculated , due to great differences of the study design and the examined drugs . The results of this literature analysis demonstrate the analgesic efficacy of weak opioids in chronic pain . Non-opioid analgesics and strong opioids , however , have greater potency . These results are based mainly on single-dose studies ; controlled long-term studies are required . Especially the risk of serious complications involving the gastrointestinal tract , kidney and blood cells during long-term treatment with non-opioid analgesics or weak opioids needs to be evaluated . In addition , the combination of non-opioid analgesics and weak opioids versus the combination of nonopioid analgesics and placebo or low-dose strong opioids has to be investigated . The results of this literature analysis support the use of weak opioids in the symptomatic treatment of chronic pain , though the evidence of the available literature is limited . It can be recommended to prescribe weak opioids according to the WHO ladder in combination with non-opioid analgesics . If this combination provides no adequate analgesic efficacy , however , the use of strong opioids must not be delayed ." ], "offsets": [ [ 0, 1577 ] ] } ]

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[]

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DerSchmerz.80120179.eng.abstr

[ { "id": "DerSchmerz.80120179.eng.abstr-passage-0", "type": "abstract", "text": [ "With regard to the potentialities of hypnosis for the treatment of pain , relevant studies on hypnotic pain control are discussed . Studies with experimentally produced pain unanimously show that hypnosis is effective in controlling pain , whereas clinical studies are much more ambiguous in this respect . Three basic strategies of hypnotic pain control are outlined to which the different techniques can be subsumed : dissociative , associative , and symbolic strategies . Accountable for the limitations of hypnosis are some issues like hypnotic state , hypnotizability , rapport , hypnotic techniques , and pain as a multifactorial process . These issues are discussed and their contribution to contraindications are outlined . Especially the differences between symptom- and problem-oriented hypnotic approaches are highlighted ." ], "offsets": [ [ 0, 834 ] ] } ]

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[]

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DerSchmerz.80120195.eng.abstr

[ { "id": "DerSchmerz.80120195.eng.abstr-passage-0", "type": "abstract", "text": [ "Hydromorphone is a µ receptor agonist opioid . According to WHO recommendations , hydromorphone is to be classified in step III of pain therapy . An oral formulation with a prolonged duration of action of 12 hours has been evaluated only recently . The controlled release capsule is especially suited for the regular twice a day administration in cases of severe and persistent pain . The oral formulation of hydromorphone increases the number of opioid analgesics available for pain therapy in step III . Hydromorphone is recommended when morphine fails to produce sufficient pain relief ( despite increase of doses ) or causes intolerable side effects ( despite treatment of symptoms ) . In principle , no differences in efficacy of morphine and hydromorphone are to be expected . However , clinical experience shows that changing one opioid analgesic to another one can improve the treatment of patients so that hydromorphone may replace another opioid analgesic to which a patient fails to respond well or develops side effects . The dose of hydromorphone equivalent to 2 times 30 mg controlled release morphine is about 2 times 4 mg . The values for the absorption , bioavailability and maximum plasma concentration after the administration of controlled release hydromorphone every 12 hours -of three times the dose- are equivalent to those of an immediate release tablet given every 4 hours . In several open label and controlled studies , hydromorphone proved to be of good efficacy in the treatment of acute and persistent pain , especially in patients with severe cancer pain . With regard to the incidence of side effects , no significant differences between morphine and hydromorphone could be established . In general , the side effects of hydromorphone are typical for opioid analgesics ." ], "offsets": [ [ 0, 1802 ] ] } ]

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[ "pain" ], "offsets": [ [ 131, 135 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 136, 143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "pain therapy" ], "offsets": [ [ 131, 143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002766" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "release" ], "offsets": [ [ 264, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0541720" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "capsule" ], "offsets": [ [ 272, 279 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006935" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "administration" ], "offsets": [ [ 329, 343 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001554" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 378, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "hydromorphone" ], "offsets": [ [ 409, 422 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012306" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "opioid" ], "offsets": [ [ 447, 453 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "analgesics" ], "offsets": [ [ 454, 464 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 479, 483 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { 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"DerSchmerz.80120195.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 577, 581 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 664, 673 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 677, 685 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s6-t6", "type": "umlsterm", "text": [ "side effects" ], "offsets": [ [ 641, 653 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001688" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "morphine" ], "offsets": [ [ 735, 743 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026549" } ] }, { "id": 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"DerSchmerz.80120195.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "hydromorphone" ], "offsets": [ [ 915, 928 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012306" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s8-t6", "type": "umlsterm", "text": [ "opioid" ], "offsets": [ [ 949, 955 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s8-t7", "type": "umlsterm", "text": [ "analgesic" ], "offsets": [ [ 956, 965 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002771" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s8-t8", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 977, 984 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s8-t9", "type": "umlsterm", "text": [ "opioid analgesic" ], "offsets": [ [ 837, 853 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002772" } ] }, { "id": "DerSchmerz.80120195.eng.abstr-s8-t10", "type": "umlsterm", "text": [ 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"interacts_with", "arg1_id": "DerSchmerz.80120195.eng.abstr-s13-t2", "arg2_id": "DerSchmerz.80120195.eng.abstr-s13-t4", "normalized": [] }, { "id": "DerSchmerz.80120195.eng.abstr-s13-r5-t2.1-t4.1", "type": "complicates", "arg1_id": "DerSchmerz.80120195.eng.abstr-s13-t2", "arg2_id": "DerSchmerz.80120195.eng.abstr-s13-t4", "normalized": [] }, { "id": "DerSchmerz.80120195.eng.abstr-s13-r6-t1.1-t4.1", "type": "affects", "arg1_id": "DerSchmerz.80120195.eng.abstr-s13-t1", "arg2_id": "DerSchmerz.80120195.eng.abstr-s13-t4", "normalized": [] }, { "id": "DerSchmerz.80120195.eng.abstr-s13-r7-t1.1-t4.1", "type": "causes", "arg1_id": "DerSchmerz.80120195.eng.abstr-s13-t1", "arg2_id": "DerSchmerz.80120195.eng.abstr-s13-t4", "normalized": [] }, { "id": "DerSchmerz.80120195.eng.abstr-s13-r8-t2.1-t1.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120195.eng.abstr-s13-t2", "arg2_id": "DerSchmerz.80120195.eng.abstr-s13-t1", "normalized": [] } ]

DerSchmerz.80120205.eng.abstr

[ { "id": "DerSchmerz.80120205.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : Comprehensive diagnosis of pain comprises assessment of subjectively felt pain as one necessary component . Modern approaches are multidimensional ( differentiation between sensory and affective parts ; multiple sub-aspects of sensory pain ) and go far beyond single-item-methods , whose utility remain questionable not only regarding the contents but for measurement purposes as well . One of these modern instruments of pain assessment , the Pain Experience Scale ( German : Schmerzempfindungsskala , SES ) , served as original for the development of a computerized version . The study aimed to establish whether this computer version is equivalent to the paper-pencil original ." ], "offsets": [ [ 0, 691 ] ] } ]

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[]

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DerSchmerz.80120209.eng.abstr

[ { "id": "DerSchmerz.80120209.eng.abstr-passage-0", "type": "abstract", "text": [ "Disturbances of small afferent nerve fibres play an important role in painful neuropathies . Quantitative thermotest offers a possibility to quantify these disturbances that can not be detected by conventional electrophysiology . It is a psychophysical method to investigate thermal and nociceptive afferents by determinating thermal thresholds . Former experiences have shown that quantitative thermotest can be a helpful tool not only in daily routine but also for research work concerning pathophysiological mechanisms of neuropathy . Therefore a multicentric approach to investigate rare painful neuropathies seems to be useful ." ], "offsets": [ [ 0, 633 ] ] } ]

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[]

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DerSchmerz.80120212.eng.abstr

[ { "id": "DerSchmerz.80120212.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : This review of radiological and other procedures used in the diagnosis of ( chronic ) low-back pain is not intended to provide a complete evaluation of the methods employed , because the validity , specificity and sensitivity of the various diagnostic measures are the subject of so much controversy that a comprehensive discussion would be beyond the scope of the present overview . The choice of method depends not only on the clinical symptoms but also on the localisation of the pain , the aetiology of which may also be related to the age of the patient ." ], "offsets": [ [ 0, 573 ] ] } ]

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DerSchmerz.80120250.eng.abstr

[ { "id": "DerSchmerz.80120250.eng.abstr-passage-0", "type": "abstract", "text": [ "Chronic pain in a distal extremity that is accompanied by autonomic dysfunction in the same region is taken to indicate reflex sympathetic dystrophy . Typically , hyperalgesia to light touch is present in addition to the spontaneous pain . The absence of heat hyperalgesia indicates that the underlying mechanism is central rather than peripheral sensitization . This mechanism is similar to that of secondary hyperalgesia in the intact skin surrounding an injury site . Sympatheti-cally maintained pain ( SMP ) is diagnosed , when these sensory symptoms are reversible under sympathetic blockade . SMP is not due to hyperactivity of sympathetic efferents but to receptor supersensitivity , probably by overexpression of 1-adrenergic receptors on nociceptive primary afferents . This way normal levels of norepinephrine can cause pathological spontaneous activity of nociceptors which maintains the central sensitization . Chronic burning pain and cutaneous hyperalgesia may also be independent of the sympathetic innervation of the skin . In this case , central sensitization is maintained by other mechanisms . A role of the sympathetic nervous system in the pathogenesis of pain cannot be deduced simply from the simultaneous presence of sensory and autonomic clinical signs and symptoms . Therefore , sympathetic blockade in a patient initially is a diagnostic procedure , aiming to demonstrate the presence of the symptom SMP . Therapeutic blockade is only indicated after this demonstration . For the substantial number of patients with sympathetically independent pain , other treatment modalities are needed which may for example attack central sensitization ." ], "offsets": [ [ 0, 1668 ] ] } ]

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DerSchmerz.80120272.eng.abstr

[ { "id": "DerSchmerz.80120272.eng.abstr-passage-0", "type": "abstract", "text": [ "In simultaneous bilateral nerve recordings , patients with Sympathetically Maintained Pain ( SMP ) affecting one limb show similar sympathetic traffic in nerves supplying the affected and unaffected limb , also when the painful limb shows a marked regional autonomic ( vasomotor ) dysfunction . These findings argue against the notion that SMP must be mediated by a reflex change in the pattern of sympathetic discharge . In general , they underline the fact that autonomic effector disturbances may give little information about underlying nerve traffic ." ], "offsets": [ [ 0, 556 ] ] } ]

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[]

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DerSchmerz.80120276.eng.abstr

[ { "id": "DerSchmerz.80120276.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Neuropathic pain syndromes may be treated by intervention at the sympathetic nervous system . The pain in these syndromes is therefore called sympathetically maintained pain ( SMP ) . Typical disorders with a SMP component are complex regional pain syndromes ( reflex sympathetic dystrophy and causalgia ) , traumatic neuralgias and herpes zoster ." ], "offsets": [ [ 0, 361 ] ] } ]

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[]

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DerSchmerz.80120282.eng.abstr

[ { "id": "DerSchmerz.80120282.eng.abstr-passage-0", "type": "abstract", "text": [ "The term \" sympathetically maintained pain \" ( SMP ) describes a symptom that might accompany a variety of diseases ( CRPS , ( post- ) herpetic and post-injury neuralgia ) , which might transform into sympathetically independent pain ( SIP ) after some time . Patients with SMP present a bunch of disorders of the autonomic and sensory system , but the only reliable way to diagnose a pain as SMP is a positive response to an intervention at the sympathetic nervous system . Three ways of influencing the sympathetic system are commonly used : ( a ) local anesthetic sympathetic blockade ( SB ) , ( b ) intravenous regional sympathectomy ( IVRS ) and ( c ) ganglionic local opioid application ( GLOA ) . A review of current literature shows that SB has certain advantages in diagnostic sensitivity , whereas GLOA might be slightly superior in therapy of some diseases with longstanding pain history . Obviously , the therapeutic benefit of all interventions is complete independent of the accompanying autonomic disorder and of a blockade of efferent fibers . A new heuristic model of the SMP mechanism is presented , including both experimental and clinical data . For reducing the risks of false positive or negative diagnosis of SMP and SIP , a diagnostic algorithm is proposed . This includes optimizing the technique , changes of interventional measures , and adequate monitoring both of analgesia and as well of the extend of efferent sympathetic blockade ( e.g. measurement of sympathetic reflexes ) . The treatment recommendations in patients with SMP vary in dependence of the kind of disease . In SMP , invasive measures play an important , but only limited role within the comprehensive treatment concept . As an example a three-stage , symptom-adapted treatment algorithm is demonstrated for CRPS , including also drug therapy , psychologic and physiotherapeutic approaches ." ], "offsets": [ [ 0, 1887 ] ] } ]

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[]

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DerSchmerz.80120323.eng.abstr

[ { "id": "DerSchmerz.80120323.eng.abstr-passage-0", "type": "abstract", "text": [ "Treatment of pain is an medical operation that requires informed consent of the patient as justification . Invasive treatment of pain causes frequently civil and sometimes even criminal responsability of the physician which can be reduced by detailed information about typical risks . Information about abuse , physical and psychological dependence and consequences on the ability to operate a vehicle must be a part of a medicinal treatment . In any treatment , the patient has a right to information about serious alternativemethods . It is the responsibility of the physician to inform the patient in a personal dialogue . Information forms can support but not replace the dialogue . In case of minority of the patient or missing expression of will the physician has to inform the legal representative ( s ) or to search for the presumed will of the patient . The information about post operative treatment should take place before the operation to keep the patients consent free of influence of anasthesia or pain caused by the operation . Treatment of pain is often not vital and additional to treatment of the basic desease , so that the physician has to inform both about the treatment of pain and of basic desease . Even by final desease a renunciation of information is possible only under very restricted circumstances . Documentation has to be a part of any information to avoid lack of evidence in a trial ." ], "offsets": [ [ 0, 1419 ] ] } ]

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[]

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"DerSchmerz.80120323.eng.abstr-s9-t2", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s7-r2-t2.1-t1.1", "type": "treats", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t2", "arg2_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s7-r3-t2.1-t3.1", "type": "treats", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t2", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t3", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s7-r4-t3.1-t2.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t3", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t2", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s8-r1-t2.2-t1.1", "type": "performs", "arg1_id": "DerSchmerz.80120323.eng.abstr-s8-t2", "arg2_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s8-r2-t2.2-t5.1", "type": "performs", "arg1_id": "DerSchmerz.80120323.eng.abstr-s8-t2", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t5", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s9-r1-t3.1-t5.1", "type": "performs", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t3", "arg2_id": "DerSchmerz.80120323.eng.abstr-s9-t5", "normalized": [] }, { "id": "DerSchmerz.80120323.eng.abstr-s9-r2-t3.1-t1.1", "type": "performs", "arg1_id": "DerSchmerz.80120323.eng.abstr-s9-t3", "arg2_id": "DerSchmerz.80120323.eng.abstr-s11-t1", "normalized": [] } ]

DerSchmerz.80120330.eng.abstr

[ { "id": "DerSchmerz.80120330.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Former studies performed by means of supravital methylene blue ( MB ) staining could demonstrate intraepidermal free nerve fiber endings ( FNE ) . Unfortunately , these publications were only illustrated by drawings . Furthermore , the practical details of the method were only insufficiently handed down to the posteriority . Therefore , a modification of the staining procedure should be worked out for this purpose . Subsequently , the possible advantages of the method compared with common histochemical techniques should be clarified . Regarding the possible nociceptive functions of the FNE , the corresponding conclusions should be drawn from the results ." ], "offsets": [ [ 0, 678 ] ] } ]

[ { "id": "DerSchmerz.80120330.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "methylene" ], "offsets": [ [ 63, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0054666" }, { "db_name": "UMLS", "db_id": "C0284756" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "nerve" ], "offsets": [ [ 132, 137 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027769" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "methylene blue" ], "offsets": [ [ 63, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025746" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "nerve fiber" ], "offsets": [ [ 132, 143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027749" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "publications" ], "offsets": [ [ 184, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034036" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "method" ], "offsets": [ [ 276, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "procedure" ], "offsets": [ [ 385, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "method" ], "offsets": [ [ 481, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 523, 533 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "DerSchmerz.80120330.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "functions" ], "offsets": [ [ 591, 600 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031843" } ] } ]

[]

[ { "id": "DerSchmerz.80120330.eng.abstr-s1-r1-t1.1-t1.2", "type": "interacts_with", "arg1_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r2-t1.1-t4.1", "type": "disrupts", "arg1_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.80120330.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r3-t1.1-t2.1", "type": "affects", "arg1_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r4-t2.1-t1.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.80120330.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r5-t4.1-t1.1", "type": "affects", "arg1_id": "DerSchmerz.80120330.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r6-t1.1-t2.1", "type": "treats", "arg1_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r7-t1.1-t2.1", "type": "evaluation_of", "arg1_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r8-t4.1-t2.1", "type": "affects", "arg1_id": "DerSchmerz.80120330.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r9-t4.1-t1.1", "type": "produces", "arg1_id": "DerSchmerz.80120330.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120330.eng.abstr-s6-t1", "normalized": [] }, { "id": "DerSchmerz.80120330.eng.abstr-s1-r10-t4.1-t1.2", "type": "produces", "arg1_id": "DerSchmerz.80120330.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120330.eng.abstr-s5-t1", "normalized": [] } ]

DerSchmerz.80120336.eng.abstr

[ { "id": "DerSchmerz.80120336.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Pain in childhood still seems to be a major problem . In this study we investigated parents ' opinion about the frequency of pain in their children and the efficacy of pain treatment ." ], "offsets": [ [ 0, 199 ] ] } ]

[ { "id": "DerSchmerz.80120336.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Pain" ], "offsets": [ [ 15, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "parents" ], "offsets": [ [ 99, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030551" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "frequency" ], "offsets": [ [ 127, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376249" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 140, 144 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "children" ], "offsets": [ [ 154, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008059" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 183, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120336.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 188, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

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DerSchmerz.80120342.eng.abstr

[ { "id": "DerSchmerz.80120342.eng.abstr-passage-0", "type": "abstract", "text": [ "Some recent studies report on slightly increased serum levels of anticardiolipin IgG antibodies in patients with migraine with and without aura ." ], "offsets": [ [ 0, 145 ] ] } ]

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[]

[ { "id": "DerSchmerz.80120342.eng.abstr-s1-r1-t4.1-t3.1", "type": "occurs_in", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t3", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r2-t1.1-t4.1", "type": "indicates", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r3-t4.1-t2.1", "type": "produces", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t2", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r4-t1.1-t2.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t2", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r5-t2.1-t4.1", "type": "indicates", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t2", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r6-t5.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t5", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r7-t4.1-t1.1", "type": "produces", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t1", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r8-t4.1-t5.1", "type": "associated_with", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t5", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r9-t1.1-t4.1", "type": "affects", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t1", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t4", "normalized": [] }, { "id": "DerSchmerz.80120342.eng.abstr-s1-r10-t2.1-t1.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120342.eng.abstr-s1-t2", "arg2_id": "DerSchmerz.80120342.eng.abstr-s1-t1", "normalized": [] } ]

DerSchmerz.80120383.eng.abstr

[ { "id": "DerSchmerz.80120383.eng.abstr-passage-0", "type": "abstract", "text": [ "The antipyretic analgesics still comprise the most widely used group of analgesic compounds . Until twenty years ago , aspirin , phenazone derivatives and acetaminophen had been used as standard remedies for intercurrent harmless pain conditions in connection with infections , trauma , small surgeries , but also for tension headache and other painful conditions . During the last decades , this group has been supplemented by a variety of 2-arylpropionic acids being primarily developed for the treatment of rheumatic pain and inflammation . Some of them ( e.g. ibuprofen , ketoprofen and naproxen ) have been given over-the-counter status in some countries because of their relative safety at low doses . Nevertheless , pharmacodynamic and pharmacokinetic differences among the various substances of this group make them suitable to a different degree for the treatment of pain conditions ." ], "offsets": [ [ 0, 893 ] ] } ]

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"DerSchmerz.80120383.eng.abstr-s5-t3", "arg2_id": "DerSchmerz.80120383.eng.abstr-s4-t5", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s2-r56-t7.1-t9.1", "type": "issue_in", "arg1_id": "DerSchmerz.80120383.eng.abstr-s2-t7", "arg2_id": "DerSchmerz.80120383.eng.abstr-s2-t9", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s2-r57-t1.1-t11.1", "type": "affects", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.80120383.eng.abstr-s2-t11", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s2-r58-t2.1-t9.2", "type": "treats", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.80120383.eng.abstr-s2-t9", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s2-r59-t1.1-t2.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s2-r60-t9.2-t8.1", "type": "associated_with", 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"associated_with", "arg1_id": "DerSchmerz.80120383.eng.abstr-s4-t4", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s3-r4-t4.1-t2.1", "type": "co-occurs_with", "arg1_id": "DerSchmerz.80120383.eng.abstr-s4-t4", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s3-r5-t1.1-t4.1", "type": "affects", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.80120383.eng.abstr-s4-t4", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s4-r1-t3.1-t2.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t3", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s4-r2-t2.1-t3.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s4-r3-t3.1-t1.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t3", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s4-r4-t1.1-t3.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t3", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s4-r5-t2.1-t1.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t1", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s4-r6-t1.1-t2.1", "type": "interacts_with", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t1", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "normalized": [] }, { "id": "DerSchmerz.80120383.eng.abstr-s5-r1-t2.1-t1.1", "type": "treats", "arg1_id": "DerSchmerz.80120383.eng.abstr-s5-t2", "arg2_id": "DerSchmerz.80120383.eng.abstr-s5-t1", "normalized": [] } ]

DerSchmerz.80120389.eng.abstr

[ { "id": "DerSchmerz.80120389.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : Regarding the coherence of sleeping behavior and the occurrence of migraine attacks , we conducted a study based on migraine and sleeping diaries ." ], "offsets": [ [ 0, 157 ] ] } ]

[ { "id": "DerSchmerz.80120389.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "behavior" ], "offsets": [ [ 46, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004927" } ] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "occurrence" ], "offsets": [ [ 63, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243132" } ] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 77, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "migraine" ], "offsets": [ [ 126, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149931" } ] }, { "id": "DerSchmerz.80120389.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "diaries" ], "offsets": [ [ 148, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376660" } ] } ]

[]

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DerSchmerz.80120400.eng.abstr

[ { "id": "DerSchmerz.80120400.eng.abstr-passage-0", "type": "abstract", "text": [ "Neck pain after whiplash injury of the cervical spine often induces typical changes in head motion patterns ( amplitude , velocity ) . These changes of kinematics may help to recognize malingerers . We investigated the hypothesis that malingerers are not able to reproduce their simulated head movement disturbances three times . The kinematics of head movements of 23 patients with neck pain after whiplash injury and of 22 healthy subjects trying to act as malingerers were compared . The healthies were informed about the symptomatology of whiplash injury and were asked to simulate painful head movements . Two different kinds of head movements were registered and analyzed by Cervicomotography : ( 1 ) the slow free axial head rotation ( yaw ) and ( 2 ) the axial head rotation ( yaw ) tracking a moving visual target . Each experimental condition was presented three times , expecting the malingerers not to be able to produce as well as to reproduce the same head movement disturbances again and again . In patients , as a consequence of their distinct pain patterns , we expected less variance between the test repetitions . The statistical analysis showed significant differences of the calculated kinematic parameters between both groups and the inability of healthy subjects to simulate and to reproduce convincingly distinct pain patterns ." ], "offsets": [ [ 0, 1352 ] ] } ]

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"umlsterm", "text": [ "head" ], "offsets": [ [ 87, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "motion" ], "offsets": [ [ 92, 98 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026597" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "Neck pain" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007859" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "whiplash injury" ], "offsets": [ [ 16, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "kinematics" ], "offsets": [ [ 152, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600169" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "simulated" ], "offsets": [ [ 279, 288 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0284447" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "head" ], "offsets": [ [ 289, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "movement" ], "offsets": [ [ 294, 302 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026649" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "times" ], "offsets": [ [ 322, 327 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "head movement" ], "offsets": [ [ 289, 302 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376591" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "kinematics" ], "offsets": [ [ 334, 344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600169" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "head" ], "offsets": [ [ 348, 352 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "movements" ], "offsets": [ [ 353, 362 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026649" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 369, 377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "neck" ], "offsets": [ [ 383, 387 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027530" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 388, 392 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "whiplash" ], "offsets": [ [ 399, 407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "injury" ], "offsets": [ [ 408, 414 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0175677" }, { "db_name": "UMLS", "db_id": "C0021501" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t9", "type": "umlsterm", "text": [ "head movements" ], "offsets": [ [ 348, 362 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376591" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t10", "type": "umlsterm", "text": [ "neck pain" ], "offsets": [ [ 383, 392 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007859" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s4-t11", "type": "umlsterm", "text": [ "whiplash injury" ], "offsets": [ [ 399, 414 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "whiplash" ], "offsets": [ [ 543, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "injury" ], "offsets": [ [ 552, 558 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0175677" }, { "db_name": "UMLS", "db_id": "C0021501" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "head" ], "offsets": [ [ 594, 598 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "movements" ], "offsets": [ [ 599, 608 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026649" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "whiplash injury" ], "offsets": [ [ 543, 558 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043145" } ] }, { "id": "DerSchmerz.80120400.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "head movements" ], "offsets": [ [ 594, 608 ] ], "normalized": [ { 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DerSchmerz.80120406.eng.abstr

[ { "id": "DerSchmerz.80120406.eng.abstr-passage-0", "type": "abstract", "text": [ "Problem : Assessment and evaluation of perceived pain is an interdisciplinary task . This study focused on the change sensitivity and construct validity of the German version of the Revised Multidimensional Pain Scale ( MSS ) ." ], "offsets": [ [ 0, 227 ] ] } ]

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[]

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DerSchmerz.90130003.eng.abstr

[ { "id": "DerSchmerz.90130003.eng.abstr-passage-0", "type": "abstract", "text": [ "Mechanisms in the lesioned muscle : The peripheral mechanism underlying the tenderness and pain during movement of a damaged muscle is the sensitization of muscle nociceptors . Ongoing activity of nociceptors causes spontaneous pain in addition to tenderness . Muscle pain ( particularly that originating in myofascial trigger points ) is often mislocalized because it is referred to other deep somatic tissues . The development of trigger points is a purely peripheral event , whereas the referral of muscle pain is based on central nervous mechanisms ." ], "offsets": [ [ 0, 554 ] ] } ]

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[]

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DerSchmerz.90130019.eng.abstr

[ { "id": "DerSchmerz.90130019.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Aim of the present prospective longitudinal study was the statistical foundation and thus further replication of recent findings of Hasenbring [ 13 ] , who postulated a significant importance of specific , within the psychological pain research long neglected pain coping strategies as risk factors concerning pain chronification : appeals to \" stick it out \" on the cognitive level and endurance strategies on the behavioural level ." ], "offsets": [ [ 0, 447 ] ] } ]

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[]

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DerSchmerz.90130031.eng.abstr

[ { "id": "DerSchmerz.90130031.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : In a cognitive perspective , chronic pain comprises at least three dimensions : First it is possible to study the relevance of pain related attitudes , beliefs and coping cognitions for the chronification of pain . Second psychological processes of learning and memory processes can be analysed . Third we can investigate uncontrolled cognitions in chronical pain patients ." ], "offsets": [ [ 0, 387 ] ] } ]

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[]

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DerSchmerz.90130043.eng.abstr

[ { "id": "DerSchmerz.90130043.eng.abstr-passage-0", "type": "abstract", "text": [ "The prescription of strong opioids underlies a special legislation . The attitude of the pharmacists towards the long-term treatment with these analgesics and their opinion about the legislation is unknown in Germany and other European countries ." ], "offsets": [ [ 0, 247 ] ] } ]

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[]

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DerSchmerz.90130048.eng.abstr

[ { "id": "DerSchmerz.90130048.eng.abstr-passage-0", "type": "abstract", "text": [ "Case : On the basis of a case report the often difficult classification of migraine with aura and exclusion of symptomatic origin is discussed . In spring 1996 a 34-years old patient started to suffer from attacks of a migraine like headache with focal aura several times a week ." ], "offsets": [ [ 0, 280 ] ] } ]

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[]

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DerSchmerz.90130087.eng.abstr

[ { "id": "DerSchmerz.90130087.eng.abstr-passage-0", "type": "abstract", "text": [ "At the end of the thirties , the first papers from Wolff and Graham represented the beginning of modern migraine research . Since that time advance is important . Several medical disciplines and special fields in research such as neurology , clinical and experimental neurophysiology , neuroradiology , psychiatry , medical psychology , psychosomatics , biochemistry , genetics , pharmacology , epidemiology contributed to the new cognitions . Further exploration of genetics and of the interictal neuronal and neurovascular dysfunctions are the key for both understanding of migraine as disease and pathogenesis of migraine attacks . All together migraine may be defined as a specific dysfunction in neuronal information processing and neurovascular reagibility corresponding with imbalance of certain neurotransmitters ( NA , 5-HT ) and leading to ictal reactions of brain areas and intracranial vessels in critical phases of hyperreagibility and hyperactivity . In the pathogenetical and pathophysiological processings both genetic and acquired mechanisms might be involved . Aura symptoms result from abnormal vasoconstriction with oligemia or ischemia of the tissue as Wolff supposed it . The headache phase follows with delay because the pain inducing neurogenic inflammation in the vessel walls need more time for clinical manifestation than the oligemic resp. ischemic brain symptoms ." ], "offsets": [ [ 0, 1393 ] ] } ]

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DerSchmerz.90130097.eng.abstr

[ { "id": "DerSchmerz.90130097.eng.abstr-passage-0", "type": "abstract", "text": [ "Complementary medicine is not a therapy without side effects . Undergoing acupuncture can result in hazardous complications . Therefore patients should be advised of adverse events associated with acupuncture . A consent form for acupuncture is presented . Only physicians with good anatomical and clinical skills should use acupuncture ." ], "offsets": [ [ 0, 338 ] ] } ]

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[]

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DerSchmerz.90130113.eng.abstr

[ { "id": "DerSchmerz.90130113.eng.abstr-passage-0", "type": "abstract", "text": [ "Objectives : We performed 52 peripheral nerve stimulation procedures since 1991. In addition to 48 patients with CRPS II , 4 patients with phantom-limb pain were treated . Incomplete or complete lesion of the stimulated peripheral nerves was determined in all patients . Surgically treatment failed in all cases . All patients had been given extensive conservative pain therapy ." ], "offsets": [ [ 0, 379 ] ] } ]

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[]

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DerSchmerz.90130127.eng.abstr

[ { "id": "DerSchmerz.90130127.eng.abstr-passage-0", "type": "abstract", "text": [ "Objective : The objective of this survey was to investigate the current status of the epidural and intrathecal management in patients with chronic cancer and non-cancer pain in Germany and Austria . Methods : In June 1997 a questionnaire was sent to 598 German and Austrian anaesthesiologists specialized in pain therapy . Questions concerning the use of medicaments for epidural and intrathecal treatment of chronic pain were asked . Results : The response rate was 23% . The data show that 78% of the anaesthesiologists use epidural or intrathecal analgesia in the therapy of chronic pain . Local anaesthetics are used by 85% of these anaesthesiologists , followed by morphine ( 72% ) , clonidine ( 48% ) , buprenorphine ( 34% ) , baclofen ( 20% ) , fentanyl ( 13% ) and sufentanil ( 10% ) . For most of the treatments local anaesthetics are used , again followed by opioids und clonidine . In the 137 answering pain clinics 79.821 epidural and intrathecal analgetic treatments are performed per year . Discussion : Epidural and intrathecal pain therapy is frequently used in Germany and Austria , either as a complementary or alternative treatment to systemic pain therapy . Local anaesthetics followed by opioids are the most commonly used medicaments for this treatment . For some of the applied substances neurotoxicological data are lacking . The use of these substances has to be considered very carefully ." ], "offsets": [ [ 0, 1415 ] ] } ]

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[]

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DerSchmerz.90130133.eng.abstr

[ { "id": "DerSchmerz.90130133.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Drug therapy plays often an important role in the treatment of chronic pain . Former studies and also experiences of clinical practice have given evidence , that insufficient patient compliance is a widespread event . Therefore drug screening becomes a significant tool for quality assurance . In the following the methodical and practical aspects of drug screening are described and recommendations for its use in clinical practice are suggested ." ], "offsets": [ [ 0, 463 ] ] } ]

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[]

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DerSchmerz.90130183.eng.abstr

[ { "id": "DerSchmerz.90130183.eng.abstr-passage-0", "type": "abstract", "text": [ "In patients with renal or hepatic failure , the pharmacokinetics of opioids may be affected in several ways , leading to the necessity to correct the dose . The liver is the major site for biotransformation of most opioids . The major metabolic pathway is oxidation . Exceptions to this are morphine and buprenorphine , which undergo primarily glucuronidation , and remifentanil which is cleared by esther hydrolysis . The hydrophilic metabolites are predominantly excreted by the kidneys and may accumulate in patients with renal insufficiency . Some metabolites such as morphine-6-glucuronide ( M6G) or normeperidine are active opioid agonists . With high concentrations they may cause narcotic effects or respiratory depression . In addition , special risks are known for normepridine that has been shown to exert neurotoxic effects with the risk of seizures . Few cases of respiratory depression following the administration of codeine , dihydrocodeine and tramdol have been reported . The elimination half-life of these drugs was prolonged . Lastly , the disposition of methadone , buprenorphine , fentanyl , sufentanyl and remifentanil appears to be unaffected in renal failure ." ], "offsets": [ [ 0, 1185 ] ] } ]

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"C0023884" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "biotransformation" ], "offsets": [ [ 189, 206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220798" }, { "db_name": "UMLS", "db_id": "C0005576" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "opioids" ], "offsets": [ [ 215, 222 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "morphine" ], "offsets": [ [ 291, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026549" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "buprenorphine" ], "offsets": [ [ 304, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006405" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "remifentanil" ], "offsets": [ [ 366, 378 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0246631" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "hydrolysis" ], "offsets": [ [ 406, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020291" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "kidneys" ], "offsets": [ [ 481, 488 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022646" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 511, 519 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "renal insufficiency" ], "offsets": [ [ 525, 544 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035078" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "morphine-6-glucuronide" ], "offsets": [ [ 572, 594 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0066816" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "normeperidine" ], "offsets": [ [ 605, 618 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0069006" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "normeperidine" ], "offsets": [ [ 605, 618 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025376" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "opioid" ], "offsets": [ [ 630, 636 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242402" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s6-t5", "type": "umlsterm", "text": [ "agonists" ], "offsets": [ [ 637, 645 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243192" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "concentrations" ], "offsets": [ [ 658, 672 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "narcotic" ], "offsets": [ [ 688, 696 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027415" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "depression" ], "offsets": [ [ 720, 730 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011570" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "risks" ], "offsets": [ [ 755, 760 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "neurotoxic" ], "offsets": [ [ 817, 827 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600688" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 845, 849 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "seizures" ], "offsets": [ [ 853, 861 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036572" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "neurotoxic effects" ], "offsets": [ [ 817, 835 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0235032" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s8-t6", "type": "umlsterm", "text": [ "risk of" ], "offsets": [ [ 845, 852 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "depression" ], "offsets": [ [ 889, 899 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011570" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s9-t2", "type": "umlsterm", "text": [ "administration" ], "offsets": [ [ 914, 928 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001554" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s9-t3", "type": "umlsterm", "text": [ "codeine" ], "offsets": [ [ 932, 939 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009214" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s9-t4", "type": "umlsterm", 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"normalized": [ { "db_name": "UMLS", "db_id": "C0015846" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s11-t4", "type": "umlsterm", "text": [ "remifentanil" ], "offsets": [ [ 1129, 1141 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0246631" } ] }, { "id": "DerSchmerz.90130183.eng.abstr-s11-t5", "type": "umlsterm", "text": [ "renal failure" ], "offsets": [ [ 1170, 1183 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035078" } ] } ]

[]

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DerSchmerz.90130196.eng.abstr

[ { "id": "DerSchmerz.90130196.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Migraine is a common neurological disorder ( 16% women , 6% men ) associated with high direct and indirect costs . We evaluated the diagnostic and paramedical therapeutic measures by estimating the expenditure per patient and the effect of treatment ." ], "offsets": [ [ 0, 264 ] ] } ]

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[]

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"normalized": [] }, { "id": "DerSchmerz.90130196.eng.abstr-s1-r6-t5.1-t2.1", "type": "diagnoses", "arg1_id": "DerSchmerz.90130196.eng.abstr-s2-t5", "arg2_id": "DerSchmerz.90130196.eng.abstr-s2-t2", "normalized": [] }, { "id": "DerSchmerz.90130196.eng.abstr-s1-r7-t4.2-t1.1", "type": "affects", "arg1_id": "DerSchmerz.90130196.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.90130196.eng.abstr-s2-t1", "normalized": [] }, { "id": "DerSchmerz.90130196.eng.abstr-s1-r8-t2.1-t4.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130196.eng.abstr-s2-t2", "arg2_id": "DerSchmerz.90130196.eng.abstr-s2-t4", "normalized": [] }, { "id": "DerSchmerz.90130196.eng.abstr-s1-r9-t4.2-t3.1", "type": "associated_with", "arg1_id": "DerSchmerz.90130196.eng.abstr-s1-t4", "arg2_id": "DerSchmerz.90130196.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.90130196.eng.abstr-s1-r10-t5.1-t1.1", "type": "affects", "arg1_id": "DerSchmerz.90130196.eng.abstr-s2-t5", "arg2_id": "DerSchmerz.90130196.eng.abstr-s2-t1", 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"affects", "arg1_id": "DerSchmerz.90130196.eng.abstr-s2-t1", "arg2_id": "DerSchmerz.90130196.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.90130196.eng.abstr-s2-r3-t6.1-t3.1", "type": "affects", "arg1_id": "DerSchmerz.90130196.eng.abstr-s2-t6", "arg2_id": "DerSchmerz.90130196.eng.abstr-s2-t3", "normalized": [] }, { "id": "DerSchmerz.90130196.eng.abstr-s2-r4-t3.1-t6.1", "type": "performs", "arg1_id": "DerSchmerz.90130196.eng.abstr-s2-t3", "arg2_id": "DerSchmerz.90130196.eng.abstr-s2-t6", "normalized": [] } ]

DerSchmerz.90130201.eng.abstr

[ { "id": "DerSchmerz.90130201.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Coenesthesias can be defined as disorders of body perception or body hallucinations , projected in different parts of the body . Patients complain of intractable pain or dysesthesia . These symptoms are reported even from organs where we usually have no perception . Coenesthesia must be regarded as a symptom that can be observed in various psychiatric diseases , e.g. , schizophrenia . However , in rare cases coenesthesias can be documented in neurological diseases , e.g. , intracranial tumors or infections . Therefore , accurate assessment of possible differential diagnoses is important . In late stages , coenesthesias can easily be recognized because of their \" bizarre \" character . In early stages , however , patients often complain of intractable , unlocalizable burning pain . They frequently undergo operations because of their great suffering . The drug treatment of first choice is neuroleptics , but the results are unpredictable ." ], "offsets": [ [ 0, 962 ] ] } ]

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"dysesthesia" ], "offsets": [ [ 183, 194 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0392699" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "intractable pain" ], "offsets": [ [ 163, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030200" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 203, 211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "perception" ], "offsets": [ [ 267, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030971" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "symptom" ], "offsets": [ [ 315, 322 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 367, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "schizophrenia" ], "offsets": [ [ 385, 398 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036341" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 473, 481 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "tumors" ], "offsets": [ [ 504, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "infections" ], "offsets": [ [ 514, 524 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "neurological diseases" ], "offsets": [ [ 460, 481 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027765" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "intracranial tumors" ], "offsets": [ [ 491, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006118" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 548, 558 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "differential diagnoses" ], "offsets": [ [ 571, 593 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011906" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "stages" ], "offsets": [ [ 617, 623 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027646" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "character" ], "offsets": [ [ 694, 703 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007952" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "stages" ], "offsets": [ [ 715, 721 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027646" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 734, 742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "burning" ], "offsets": [ [ 789, 796 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006434" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 797, 801 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s8-t5", "type": "umlsterm", "text": [ "burning pain" ], "offsets": [ [ 789, 801 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0234230" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s9-t1", "type": "umlsterm", "text": [ "operations" ], "offsets": [ [ 828, 838 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s10-t1", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 878, 882 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s10-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 883, 892 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s10-t3", "type": "umlsterm", "text": [ "choice" ], "offsets": [ [ 902, 908 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008300" } ] }, { "id": "DerSchmerz.90130201.eng.abstr-s10-t4", "type": "umlsterm", "text": [ "neuroleptics" ], "offsets": [ [ 912, 924 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040615" } ] } ]

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