knowledgator/bio-NER-relations · Datasets at Hugging Face

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The impact of long-term intermittent urokinase therapy in patients with end-stage coronary artery disease and refractory angina pectoris leads to a marked improvement of clinical symptoms . Oral blockade of platelet membrane glycoprotein IIb/IIIa receptor and clinical trials regarding antiischemic effects of low-molecular weight heparins in chronic coronary syndromes are expected for the future ." ], "offsets": [ [ 0, 1074 ] ] } ]	[ { "id": "ZfuerKardiologie.8087s145.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 15, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.8087s145.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 46, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.8087s145.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 93, 102 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerKardiologie.8087s145.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "platelet" ], 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In this review , potential catheter-based strategies for a differential interventional treatment of patients with coronary artery disease are discussed ." ], "offsets": [ [ 0, 819 ] ] } ]	[ { "id": "ZfuerKardiologie.8087s157.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 36, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.8087s157.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "devices" ], "offsets": [ [ 87, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0699733" }, { "db_name": "UMLS", "db_id": "C0220819" } ] }, { "id": "ZfuerKardiologie.8087s157.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "dilatation" ], "offsets": [ [ 118, 128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012356" }, { "db_name": "UMLS", "db_id": "C0012359" } ] }, { "id": "ZfuerKardiologie.8087s157.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ 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A steadily growing number of patients with proximal LAD lesions are submitted to cardiac surgery and the procedure is performed with increasing success rates , now approaching 98% short term patency ." ], "offsets": [ [ 0, 778 ] ] } ]	[ { "id": "ZfuerKardiologie.8087s175.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "direct" ], "offsets": [ [ 19, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0700157" } ] }, { "id": "ZfuerKardiologie.8087s175.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 35, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.8087s175.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 49, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.8087s175.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "method" ], "offsets": [ [ 83, 89 ] ], "normalized": [ { "db_name": "UMLS", 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Furthermore diffuse perfusion abnormalities reduce the sensitivity of electrocardiographic and scintigraphic detection of ischemic changes . In contrast indirect measures of ischemia relating to the systolic or diastolic function of the left ventricle like dopplerechocardiography and radionuclide ventriculography seem to be promising approaches . This is confirmed by the results from the application of long-term intermittent urokinase therapy . Long-term intermittent urokinase therapy leads to an absolute enhancement of myocardial perfusion , which makes this approach superior to other medical interventions which are mainly based on a reduction of cardiac work-load ." ], "offsets": [ [ 0, 1386 ] ] } ]	[ { "id": "ZfuerKardiologie.8087s188.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.8087s188.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "angina" ], "offsets": [ [ 25, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002962" } ] }, { "id": "ZfuerKardiologie.8087s188.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 64, 70 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.8087s188.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 71, 78 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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ZfuerKardiologie.8087s193.eng.abstr	ZfuerKardiologie.8087s193.eng.abstr	[ { "id": "ZfuerKardiologie.8087s193.eng.abstr-passage-0", "type": "abstract", "text": [ "Pneumatic external counterpulsation operates by applying ECG-triggered diastolic pressure via cuffs to the vascular bed of the lower limbs . Comparable with intra-aortic balloon pumping , PECP produces a diastolic augmentation combined with increase of mean arterial pressure and coronary perfusion . American , Asian , and our own data demonstrated a reduction of angina pectoris through repeated use of PECP one or two hours daily for four to seven weeks . Exercise testing and thallium scanning confirmed the clinical improvement . PECP is a virtually riskfree treatment option in patients suffering from angina despite medical and interventionell treatment . Opening of collaterals and collateral growth induced by external counterpulsation are discussed as the cause of clinical benefit ." ], "offsets": [ [ 0, 793 ] ] } ]	[ { "id": "ZfuerKardiologie.8087s193.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "counterpulsation" ], "offsets": [ [ 19, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010216" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 81, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "bed" ], "offsets": [ [ 116, 119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004916" }, { "db_name": "UMLS", "db_id": "C0596170" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "limbs" ], "offsets": [ [ 133, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015385" } ] }, { "id": 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ZfuerKardiologie.8087s199.eng.abstr	ZfuerKardiologie.8087s199.eng.abstr	[ { "id": "ZfuerKardiologie.8087s199.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Does transmyocardial laser revascularization ( TMLR ) as a new surgical technique for treating patients with otherwise intractable angina pectoris improve myocardial perfusion or contractility ? Methods : Sixty-seven patients transferred for TMLR were evaluated by clinical evaluation , treadmill stress testing , echocardiography , ventriculography , and hybrid positron emission tomography preoperatively and in patients treated with TMLR at 6 and 12 month follow up . Hemodynamic assessment and clinical evaluation were performed perioperatively . Results : In 28/67 cases ( 42% ) CABG , in 9/67 patients ( 13% ) CABG in combination with TMLR ( combined group ) , and in 30/67 patients ( 45% ) only TMLR ( sole group ) were performed . Perioperative mortality in the sole group was 13% , in the combined group zero , and in the CABG group 11% . In all groups a significantly improved clinical status ( p =0 . 01 ) 1 week postoperatively and in TMLR groups also at 6 and 12 months was observed . In the TMLR groups treadmill tolerance ( p 0.05 ) improved , although function , perfusion and metabolism did not change significantly at the 6 and 12 month follow up . Conclusion : TMLR significantly improves clinical status and treadmill stress tolerance , but does not change function , perfusion , and metabolism ." ], "offsets": [ [ 0, 1329 ] ] } ]	[ { "id": "ZfuerKardiologie.8087s199.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "laser" ], "offsets": [ [ 34, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023089" } ] }, { "id": "ZfuerKardiologie.8087s199.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 76, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.8087s199.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "technique" ], "offsets": [ [ 85, 94 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.8087s199.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 108, 116 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.8087s199.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "angina" ], "offsets": [ [ 144, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002962" } ] }, { "id": "ZfuerKardiologie.8087s199.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "perfusion" ], "offsets": [ [ 179, 188 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031001" } ] }, { "id": "ZfuerKardiologie.8087s199.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "angina pectoris" ], "offsets": [ [ 144, 159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002962" } ] }, { "id": "ZfuerKardiologie.8087s199.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "Methods" ], "offsets": [ [ 208, 215 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.8087s199.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 230, 238 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.8087s199.eng.abstr-s2-t3", "type": 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Therapy primarily aims at life style changes , secession of smoking and weight reduction as well as dietary changes to achieve LDL-cholesterol levels of 115-175 mg/dl ( 3-4 . 5 mmol/L ) , depending on the individual risk constellation . This strategy allows to reduce the number of patients needed to treat in order to prevent one CAD event ( 56 in isolated hypercholesterolemia ) to 14-24 in high risk persons , approaching the number ( n=13) known for effective lipid lowering in secondary prevention of coronary heart disease ." ], "offsets": [ [ 0, 1145 ] ] } ]	[ { "id": "ZfuerKardiologie.8087s205.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 26, 32 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.8087s205.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 33, 40 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.8087s205.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "CAD" ], "offsets": [ [ 43, 46 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0170509" }, { "db_name": "UMLS", "db_id": "C0010068" } ] }, { "id": "ZfuerKardiologie.8087s205.eng.abstr-s1-t4", "type": 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Especially in elderly patients , those with a complicated course of disease , those who find adjusting their life style to the chronic disease state a daunting task , and those who find coping with the fact of being chronically ill as surpassing their psychological skills will find only in an inpatient setting all the relevant support delivered by a team of experts complementing each other for the benefit of the patient ." ], "offsets": [ [ 0, 840 ] ] } ]	[ { "id": "ZfuerKardiologie.8087s225.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Outpatient" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029921" } ] }, { "id": "ZfuerKardiologie.8087s225.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "rehabilitation" ], "offsets": [ [ 19, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034991" }, { "db_name": "UMLS", "db_id": "C0034992" } ] }, { "id": "ZfuerKardiologie.8087s225.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "inpatient" ], "offsets": [ 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In addition , other striking noncardial manifestations of hypoparathyroidism , e.g. , convulsive seizures , had been present prior to cardiac symptoms ." ], "offsets": [ [ 0, 457 ] ] } ]	[ { "id": "ZfuerKardiologie.90880010.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Hypocalcemia" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020598" } ] }, { "id": "ZfuerKardiologie.90880010.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "cause" ], "offsets": [ [ 49, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "ZfuerKardiologie.90880010.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 69, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880010.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "congestive heart failure" ], "offsets": [ [ 58, 82 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018802" } ] }, { "id": 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"db_name": "UMLS", "db_id": "C0036572" } ] }, { "id": "ZfuerKardiologie.90880010.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 447, 455 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "ZfuerKardiologie.90880010.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "convulsive seizures" ], "offsets": [ [ 391, 410 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0751494" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880010.eng.abstr-s1-r1-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerKardiologie.90880010.eng.abstr-s4-t2", "arg2_id": "ZfuerKardiologie.90880010.eng.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerKardiologie.90880010.eng.abstr-s1-r2-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerKardiologie.90880010.eng.abstr-s4-t2", "arg2_id": "ZfuerKardiologie.90880010.eng.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880010.eng.abstr-s2-r1-t4.1-t1.1", "type": "occurs_in", "arg1_id": 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ZfuerKardiologie.90880014.eng.abstr	ZfuerKardiologie.90880014.eng.abstr	[ { "id": "ZfuerKardiologie.90880014.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice ." ], "offsets": [ [ 0, 162 ] ] } ]	[ { "id": "ZfuerKardiologie.90880014.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 29, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880014.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "epidemiological studies" ], "offsets": [ [ 51, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002783" } ] }, { "id": "ZfuerKardiologie.90880014.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "clinical trials" ], "offsets": [ [ 84, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008976" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880014.eng.abstr-s1-r1-t1.1-t3.1", "type": "location_of", "arg1_id": "ZfuerKardiologie.90880014.eng.abstr-s1-t1", "arg2_id": "ZfuerKardiologie.90880014.eng.abstr-s1-t3", "normalized": [] } ]
ZfuerKardiologie.90880023.eng.abstr	ZfuerKardiologie.90880023.eng.abstr	[ { "id": "ZfuerKardiologie.90880023.eng.abstr-passage-0", "type": "abstract", "text": [ "Todate internal mammary artery ( IMA ) is routinely used in coronary artery bypass grafting even in elder patients . However in patients with poor left ventricular function use of the IMA is discussed controversely in Germany . Main arguments against IMA are an increased operation time , initially lower blood flow , higher rates of reoperation for bleeding and more perioperative complications . In this study we investigated use of the IMA in patients with poor left vantricular function ( LVEF 40% ) compared to exclusively veingraft bypass surgery . 137 patients ( 105 m/32 f ) suffering from coronary artery disease with reduced LVEF ( 12-40% ) were randomized in the study . 67 patients received exclusively vein grafts ( group I ) , 70 patients routinely obtained an IMA graft . Criteria used for evalutation of IMA graft were operation time , postoperative bleeding , need for catecholamines , requirement of intensive care , perioperactive myocardial infarction and mortality . The number of distal anastomoses in each group was 3.1 ( 2-5 ) . The operation time varied in compliance with the number of distal anastomoses , but there were no significant differences between both groups . Postoperative bleeding until the secondpostoperative day was 905 ml in group II versus 569 ml in group I ; the difference was significant ( p 0.05 ) . The need of catecholamines after operation and hemodynamic parameters were comparable in both groups , there were no significant differences . Intensive care was required for a mean of 1.6 days in both groups , postoperative ventilation was 5.8 hours in group I versus 7.9 hours in group II , differences not significant . Ischemia or myocardial infarction could be demonstrated in 2 patients of group I ( 3% ) versus 4 patients of group II ( 5.7% ) . The differences between the groups were not significant . Cardiac low output syndromes without sights of myocardial infarction were apparent in 9 patients of group I ( 13.5% ) versus 2 patients of group II ( 2.9% ) , this difference being significant ( p 0.05 ) . Mortality after operation in both groups was higher than in patients with normal ventricular function , however the differences between the evaluated groups were not significant ( 5.9% in group I versus 4.3% in group II ) . Summarizing the above it can be concluded that patients with poor left ventricular function are at a higher riak when subjected to bypass operation ; the use of IMA did not show any disadvantages in comparison to exclusively veingraft surgery , except of a higher perioperative bleeding risk . Due to better long term results IMA should be used routinely also in bypass-patients with poor left ventricular function ." ], "offsets": [ [ 0, 2704 ] ] } ]	[ { "id": "ZfuerKardiologie.90880023.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Todate" ], "offsets": [ [ 0, 6 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011008" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 24, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 69, 75 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "elder" ], "offsets": [ [ 100, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 106, 114 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "mammary artery" ], "offsets": [ [ 16, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024661" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "internal mammary artery" ], "offsets": [ [ 7, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0226276" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "coronary artery bypass" ], "offsets": [ [ 60, 82 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010055" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 128, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "function" ], "offsets": [ [ 164, 172 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031843" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 173, 176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 218, 225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "ventricular function" ], "offsets": [ [ 152, 172 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0080309" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "left ventricular function" ], "offsets": [ [ 147, 172 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0080310" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "operation" ], "offsets": [ [ 272, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 282, 286 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 305, 310 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "reoperation" ], "offsets": [ [ 334, 345 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035110" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 382, 395 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.90880023.eng.abstr-s4-t1", "type": 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ZfuerKardiologie.90880034.eng.abstr	ZfuerKardiologie.90880034.eng.abstr	[ { "id": "ZfuerKardiologie.90880034.eng.abstr-passage-0", "type": "abstract", "text": [ "Within the Cologne Model ( CM ) of outdoor cardiac rehabilitation ( OCR ) , phase II investigations about demand for this form of cardiac rehabilitation ( CR ) after acute cardiac diseases were carried out in three general hospitals , the cardiological and cardiosurgical university hospitals of Cologne . The subsequent questions were investigated : total number of coronary or cardiac operated patients , number of patients with indication for CR , and number of patients corresponding to the restricted indications of CM ( age below 65 , low risk patient , no cardiac operation ) . For these groups the acceptance or refusal of CR was checked . Subsequently a sample of patients corresponding to the criteria of CM or of operated patients were confronted with the additional offer of an OCR . The motivation for acceptance of rehabilitation in specialized hospitals ( ICR ) , OCR or refusal of each kind of CR was inquired ." ], "offsets": [ [ 0, 927 ] ] } ]	[ { "id": "ZfuerKardiologie.90880034.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "rehabilitation" ], "offsets": [ [ 51, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034991" }, { "db_name": "UMLS", "db_id": "C0034992" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "form" ], "offsets": [ [ 122, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376315" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "rehabilitation" ], "offsets": [ [ 138, 152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034991" }, { "db_name": "UMLS", "db_id": "C0034992" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 180, 188 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "hospitals" ], "offsets": [ [ 223, 232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019994" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "university" ], "offsets": [ [ 272, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041740" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "hospitals" ], "offsets": [ [ 283, 292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019994" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "cardiac diseases" ], "offsets": [ [ 172, 188 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018799" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "general hospitals" ], "offsets": [ [ 215, 232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020008" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "university hospitals" ], "offsets": [ [ 272, 292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020028" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 396, 404 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 417, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 465, 473 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880034.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 526, 529 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" }, { "db_name": "UMLS", "db_id": "C0001811" } ] }, 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ZfuerKardiologie.90880044.eng.abstr	ZfuerKardiologie.90880044.eng.abstr	[ { "id": "ZfuerKardiologie.90880044.eng.abstr-passage-0", "type": "abstract", "text": [ "This epidemiologic , retrospective follow-up mortality study is based on the data gathered in the department of forensic medicine at the University Hospital of Johann Wolfgang Goethe University in Frankfurt/Main . Over a period of 21 years ( 1972-1992 ) , roughly 21,000 forensic autopsies revealed 39 cases ( 0.19% ) of natural deaths occuring during sexual activity . Except for two women , all of these cases were men of an average age of 61.3 years . The most frequent cause of death was myocardial infarction ( n=21/53.8%), three of these cases involving pericardial tamponade accompanied by myomalacia . The medical history of twelve of the deceased showed a previous myocardial infarction . Most of the deaths took place during or after sexual intercourse or manual stimulation . In most cases sudden death occured during the sexual act with a prostitute . The annual incidence of sudden cardiovascular deaths during sexual activity is estimated to be 0.2/100,000 men . 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Preventive measures have their own prize ; in general they are considered not to prevent coronary heart disease but retard it . Therefore , such therapeutic interventions can be assumed not to reduce but rather to increase the \" direct \" medical costs . Furthermore , successful prevention of coronary heart disease leads , due to life-prolongation , to an increase in people out of work and in disabled patients due to age and/or disease . Therefore , an increase especially of the \" indirect \" costs for unemployment , pension , nursing homes , etc. must be expected ." ], "offsets": [ [ 0, 1293 ] ] } ]	[ { "id": "ZfuerKardiologie.90880085.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "secondary" ], "offsets": [ [ 3, 12 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027627" }, { "db_name": "UMLS", "db_id": "C0036525" } ] }, { "id": "ZfuerKardiologie.90880085.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "prevention" ], "offsets": [ [ 13, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0687732" } ] }, { "id": "ZfuerKardiologie.90880085.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "lipid" ], "offsets": [ [ 93, 98 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023779" } ] }, { "id": "ZfuerKardiologie.90880085.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "drugs" ], "offsets": [ [ 108, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": 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After placing a quadripolar transesophageal catheter , atrial and ventricular signals were recorded and atrial stimulation performed . Atrial cycle length of tachycardia ranged from 160-380 ms with 1:1 to 4:1 AV conduction . Temporary transesophageal pacing was performed following an algorithm starting with 4 extrastimuli ( 20 ms below atrial cycle length of tachycardia ) . Tachycardia terminated in 27 of 29 cases ( 93% ) without complications . In 3 cases , conversion was achieved by pacing after amiodarone 5 mg/kg i.v. After tachycardia conversion , sinus- or pacemaker rhythm was present in 20 cases . In 9 cases atrial fibrillation was recorded ; spontaneous conversion to sinus rhythm occurred after a maximum of 3 min ( 7 cases ) or persisted and required direct current cardioversion ( 2 cases ) . In conclusion , transesophageal atrial pacing is an effective , relatively noninvasive method for conversion of atrial reentrant tachycardias after operation for congenital heart disease ." ], "offsets": [ [ 0, 1719 ] ] } ]	[ { "id": "ZfuerKardiologie.90880097.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "tachycardias" ], "offsets": [ [ 17, 29 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039231" } ] }, { "id": "ZfuerKardiologie.90880097.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "ART" ], "offsets": [ [ 32, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003826" } ] }, { "id": "ZfuerKardiologie.90880097.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "complication" ], "offsets": [ [ 73, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.90880097.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "survivors" ], "offsets": [ [ 89, 98 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206194" } ] }, { "id": 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The intraoperative defibrillation threshold ( DFT ) was evaluated in a step-down protocol ( 15 , 10 , 8 , 5 J ) and hat to be =15 J for inclusion into the study . The lowest effective energy terminating induced ventricular fibrillation had to be confirmed and was defined as DFT+ augmented defibrillation threshold . The DFT+ value was tested immediately after successful implantation , at discharge , and after a follow-up period of one year . Prior to implantation the patients were randomized into two groups . The energy of the first shock in the study group was programmed at twice DFT+ and in the control group at the maximum energy output ( 34 J ) . The efficacy of the first shock and its reproducibility in DFT testings and in spontaneous episodes during long-term follow-up of the study group were compared to those in the control group . A DFT+ value was found to be =15 J in 166 of 176 patients ( 94% ) . The DFT+ in the study group was 9.6+/-3.2; in control group 10.1+/-.35 J. The prohability of successful defibrillation at DFT+ level after one year was 84% . The success rate of the first shock meant to terminate induced ventricular fibrillation ( VF ) was 99.5% in the study group ( 217 of 218 episodes ) and 99% in the control group ( 201 of 203 episodes ) . During follow-up of 24+/-9 months spontaneous episodes in the study group , 83/86 ( 96.5 ) monomorphic ventricular tachycardias ( MVT ) and 38/40 ( 95% ) VF-episodes were converted successfully by the 2x DFT+ shock . In the control group the first shock was successful in 151/156 ( 96.8% ) spontaneous MVTs and in 30/33 ( 91% ) VF episodes . The efficacy of the first shock was not influenced by clinical data such as the underlying cardiac disease , left ventricular function , ongoing antiarrhythmic therapy with amiodarone , or the number of spontaneous episodes per day or by the DFT itself . At a mean follow-up of two years there was no significant difference between the two groups concerning the incidence of sudden cardiac death ( 2.4% in the study group vs. 3.8% in the control group ) . In conclusion programming the first shock with the ICD lead system used in this study at 2x DFT+ is as efficient as a shock energy of 34 J in order to terminate induced and spontaneous episodes of VT/VF . 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Furthermore , ergometric performance on predefined heart rate levels was significantly ( p 0.001 ) increased : 85/min: from 56.0+/-24.1 to 65.8+/-24.5 W ; 90/min: from 62.0+/-27.3 to 71.2+/-26 W ; 95/min: from 67.2+/-26.4 to 77.5+/-27.6 W ; 100/min: from 71.1+/-29.6 to 80.6+/-28.1 W ; 105/min: from 69.8+/-26.2 to 81.9+/-28.2 W and 110/min: from 73.6+/-28.9 to 90.4+/-29.4 W. The results demonstrate that physical performance in patients with CAD was improved by our novel ambulatory cardiac rehabilitation program . This improvement included an increase in maximum as well as endurance work capacity ; furthermore , this increase was accompanied by a decrease in resting and exercise heart rates . The results demonstrate an absolute increase of physical performance , more importantly an increase of physical performance at defined lactate levels in the presence of unchanged heart rates mediated by the rehabilitation program . Thus , this increase was independent of motivational factors in the patients and/or the investigators during the re-exercise test . On the contrary , our data demonstrate that it is based on an improvement of aerobic endurance capacity associated with a therapeutically beneficial significant decrease of heart rate for a defined workload . The effects were independent of pharmacological influences ( e.g. , -receptor antagonists ) . These findings are of clinical importance with respect to reduction of myocardial oxygen consumption in patients with CAD ." ], "offsets": [ [ 0, 2295 ] ] } ]	[ { "id": "ZfuerKardiologie.90880113.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "cardiacc" ], "offsets": [ [ 27, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007144" } ] }, { "id": "ZfuerKardiologie.90880113.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "rehabilitation" ], "offsets": [ [ 36, 50 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034991" }, { "db_name": "UMLS", "db_id": "C0034992" } ] }, { "id": "ZfuerKardiologie.90880113.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "program" ], "offsets": [ [ 51, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376691" } ] }, { "id": "ZfuerKardiologie.90880113.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 65, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": 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ZfuerKardiologie.90880123.eng.abstr	ZfuerKardiologie.90880123.eng.abstr	[ { "id": "ZfuerKardiologie.90880123.eng.abstr-passage-0", "type": "abstract", "text": [ "Stent implantation serves as the gold standard for proximal lesions of the coronary arteries with a diameter between 2.75-3.5 mm . Our new concept aims at a reduced procedure duration and fluoro-time as well as a decreased ischemic period during stent implantation . A new therapeutic concept of a direct stent implantation without predilatation was tested using a specially developed balloon catheter on which various 14-16 mm long \" slotted-tube \" stents are mounted between two conical , radiopaque markers . In 105 consecutive patients , who were scheduled for angioplasty , this method of direct stent implantation was performed . Six of the procedures were performed for acute myocardial infarction and 8 in socalled high-risk procedures . The direct stent implantation was successful in 88% . In 6% , predilatation of the lesion site was necessary before stent placement . In the remaining 6% , a stent could not be successfully implanted despite the availability of various other systems . Comparison of the direct stent implantation with conventional stent placement with predilatation revealed that 1 ) The fluoro-time for direct stent implantation , compared to the conventional method , was 8.4+/-4.9 min vs. 13.7+/-8.0 min ; p 0.05 , respectively . Furthermore , there were less balloons used per lesion for direct stent implantation ( 1.4+/-0.4) compared to the conventional method ( 1.7+/-0.7), but there was not a significant difference . 2 ) If we compare those patients with successful direct stent implantation with those with the unsuccessful procedures , the latter group had a higher percent of angiographically visible calcification at the site of the lesion ( 80% vs. 18% ; p 0.01 ) . In addition , these patients had an increased average age ( 72+/-7 vs. 61+/-11 yrs ; p 0.01 ) . The success rate of direct stent implantation did not depend on lesion diameter stenosis before PTCA . Stent dislocation was observed in 3.8% of the procedures , and a single case of stent embolism was seen . In conclusion , the direct stent implantation offers the advantages of a shortened fluoro-time , the use of fewer balloons , and has the potential of less ischemic stress compared to the conventional method of stent implantation with predilatation , if old patients with calcified lesions are excluded . This should be proved on a large scale in future studies also considering a learning curve with regard to the new method . Whether this new approach also reduces the restenosis rate , warrants further studies ." ], "offsets": [ [ 0, 2528 ] ] } ]	[ { "id": "ZfuerKardiologie.90880123.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Stent" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] }, { "id": "ZfuerKardiologie.90880123.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "implantation" ], "offsets": [ [ 6, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029976" } ] }, { "id": "ZfuerKardiologie.90880123.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "gold" ], "offsets": [ [ 33, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018026" } ] }, { "id": "ZfuerKardiologie.90880123.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "standard" ], "offsets": [ [ 38, 46 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038137" }, { "db_name": "UMLS", "db_id": "C0175675" } ] }, { "id": "ZfuerKardiologie.90880123.eng.abstr-s1-t5", "type": "umlsterm", "text": [ 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ZfuerKardiologie.90880133.eng.abstr	ZfuerKardiologie.90880133.eng.abstr	[ { "id": "ZfuerKardiologie.90880133.eng.abstr-passage-0", "type": "abstract", "text": [ "An increased pulmonary vascular resistance ( PVR ) or an increased transpulmonary gradient ( TPG ) is a risk factor for increased 3-day and 3-month mortality after heart transplantation ( HTx ) . The reversibility of increased PVR or TPG under pharmacologic testing is supposed to indicate a decreased probability of right ventricular failure/death after transplantation . We tested the response of an increased PVR ( > 2.5 Wood units , WU ) and/or of an increased TPG ( > 15 mm Hg ) in 29 right heart catheterizations ( thermodilution catheter ) of 23 patients ( 54+/-8 years , mean NYHA-class 3.1+/-0.6, ischemic n=8, dilated cardiomyopathy n=15). Increasing doses of prostaglandin I2 ( PGI2, mean maximum dose 13.5+/-6.4 ng/kg/min ) were applied stepwise over at least 10 min at the maximum dose level . We analzyed any dependence of the reversibility of PVR and TPG under prostaglandin I2 on hemodynamic values , echocardiographic parameters , demographic data , and laboratory findings . A decrease of PVR to a range usually accepted as no contraindication for HTx ( =4 WU ) was found in each patient without symptomatic systemic hypotension during application of PGI2 ( baseline value : 4.7+/-1.3 WU , during PGI2: 2.3+/-0.6 WU ) . An unresponsive , fixed increased PVR or TPG was not observed using PGI2. In 62% of investigations , both PVR and TPG decreased below 2.5 WU and 15 mm Hg , respectively . The extent of reversibility of PVR and TPG was individually different and did not depend on the mean pulmonary artery pressure , mean capillary wedge pressure , cardiac output , mean systemic artery pressure or echocardiographic parameters ( EDD , FS , ES-distance ) , sodium , urea or bilirubin levels , medication , age of the patients or the duration of the disease . The baseline PVR correlated inversely with its percentile value during PGI2 ( r=-0.76, p 0.05 ) . In advanced heart failure , PGI2 decreases PVR in ranges of lower risk concerning orthotopic HTx , without causing an intolerable systemic hypotension . The individual extent of reversibility of PVR and TPG under PGI2 is not influenced by basic hemodynamic parameters or the patient's demographic profile ." ], "offsets": [ [ 0, 2184 ] ] } ]	[ { "id": "ZfuerKardiologie.90880133.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 104, 108 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "ZfuerKardiologie.90880133.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 148, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "ZfuerKardiologie.90880133.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 164, 169 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880133.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "transplantation" ], "offsets": [ [ 170, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029216" }, { 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The following coronary angiography revealed RCA stent occlusion . HIT type II was presumed and recanalization was carried out using Lepirudin ( Refludan ) as the anticoagulant . After placing the guide wire , thrombi could be seen in the proximal RCA . Abciximab ( Reo pro ) , a monoclonal antibody against the glycoprotein IIb/IIIa receptor was additionally administered . Coronary angiography on the next day revealed only a small remaining thrombus . The AV-block disappeared immediately after revascularization . The diagnosis of HIT type II was confirmed through heparin-induced-platelet-activation-test ( Hipa-test ) and immunoassay ( PF 4/heparin-ELISA). This case report illustrates the complicated diagnosis of HIT type II and the successful simultaneous use of Lepirudin ( Refludan ) and Abciximab ( Reo pro ) . The number of platelets should be checked daily during heparin treatment . In the case of a thrombocytopenia , the treatment should be stopped immediately , and Hipa-test and PF 4/heparin-ELISA should be carried out ." ], "offsets": [ [ 0, 1849 ] ] } ]	[ { "id": "ZfuerKardiologie.90880141.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Abstract" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000857" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "Heparin" ], "offsets": [ [ 9, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019134" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "thrombocytopenia" ], "offsets": [ [ 25, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040034" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "complication" ], "offsets": [ [ 86, 98 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "heparin" ], "offsets": [ [ 102, 109 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019134" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 110, 119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "side effect" ], "offsets": [ [ 167, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001688" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "grafting" ], "offsets": [ [ 215, 223 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040732" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "old" ], "offsets": [ [ 236, 239 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 240, 247 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 283, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "thrombocytopenia" ], "offsets": [ [ 300, 316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040034" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "postoperative" ], "offsets": [ [ 353, 366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032790" } ] }, { "id": "ZfuerKardiologie.90880141.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "thrombocytopenia" ], "offsets": [ [ 367, 383 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040034" } ] }, { "id": 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Depending on the clinical aspect , the complaints , and on the basis of morphologic and hemodynamic investigational results , we mainly have to consider two types of medical and surgical management ." ], "offsets": [ [ 0, 522 ] ] } ]	[ { "id": "ZfuerKardiologie.90880163.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Hypertrophic" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020564" } ] }, { "id": "ZfuerKardiologie.90880163.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "cardiomyopathy" ], "offsets": [ [ 13, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027049" } ] }, { "id": "ZfuerKardiologie.90880163.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 41, 48 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880163.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "morphological" ], "offsets": [ [ 78, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543482" } ] }, 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A direct comparison of class I and III antiarrhythmic drugs , which still are most frequently used for this indication , and of placebo will answer this question . 3. How safe is the long-term treatment for the prevention of AF recurrences with special respect to proarrhythmic effects ? The daily transtelephonic ECG transmission enables a quantitative and qualitative monitoring of tachy- and bradyarrhythmias independent of symptoms . Additionally , the daily analysis of ECG measures may detect parameters predicting subsequent life threatening arrhythmias ." ], "offsets": [ [ 0, 1351 ] ] } ]	[ { "id": "ZfuerKardiologie.90880195.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "arrhythmia" ], "offsets": [ [ 56, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003811" } ] }, { "id": "ZfuerKardiologie.90880195.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "Atrial fibrillation" ], "offsets": [ [ 0, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004238" } ] }, { "id": "ZfuerKardiologie.90880195.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cardiac arrhythmia" ], "offsets": [ [ 48, 66 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003811" } ] }, { "id": "ZfuerKardiologie.90880195.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "publications" ], "offsets": [ [ 96, 108 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034036" } ] }, { "id": "ZfuerKardiologie.90880195.eng.abstr-s2-t2", 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ZfuerKardiologie.90880208.eng.abstr	ZfuerKardiologie.90880208.eng.abstr	[ { "id": "ZfuerKardiologie.90880208.eng.abstr-passage-0", "type": "abstract", "text": [ "In a prospectively designed randomized study , we compared the efficacy of sublingual nitroglycerine and intravenous enalaprilat in the out-of-hospital treatment of 46 hypertensive patients with pulmonary edema ( defined as rales over both lungs and systolic blood pressure > 200 mm Hg and diastolic blood pressure > 100 mg ) . The out-of-hospital treatment consists of oxygen ( 6 Ll/min ) via a face mask , furosemide 80 mg i.v. , opioids 10 mg s.c. , and either sublingual nitroglycerine ( n=23; initial dose : 0.8 mg ; repetitive application of 0.8 mg every 10 min until a cumulative dose of 3.2 mg ) or intravenous enalaprilat ( initial dose : 2.5 mg ; repetitive application of 2.5 mg every 30 min until a cumulative dose of 10 mg ) . The aim of the antihypertensive treatment was a reduction of systolic blood pressure below 160 mm Hg and diastolic blood pressure below 90 mm Hg until admission to the emergency department . In the emergency room , an arterial and venous blood sample was taken to determine the respiratory ( pO2, pCO2) and metabolic status ( pH value ; base-excess ; serum lactate ) of the patient . Successful antihypertensive treatment was observed in 13/23 ( 57% ) patients of the enalaprilat group and 15/23 ( 65% ) patients of the nitroglycerine group ( p=0.54). Systolic and diastolic blood pressure on admission were similiar in both treatment groups ( systolic RR : enalaprilat : 179 [ 31 ] mm Hg ; nitroglycerine : 184 [ 38 ] mm Hg ; p=0.59; diastolic RR : enalaprilat : 96 [ 14 ] mm Hg ; nitroglycerine : 101 [ 14 ] mm Hg ; p=0.12). No significant differences were observed between the enalaprilat and the nitroglycerine groups concerning respiratory and metabolic parameters on admission ( pO2: 67 [ 15 ] vs. 64 [ 17 ] mm Hg ; p=0.50; pCO2: 46 [ 9 ] vs. 47 [ 13 ] ; p=0.75; pH value : 7.27 [ 0.12 ] vs. 7.27 [ 0.09 ] ; p=0.98; BE : -4 . 2 [ 3.7 ] vs. -5 . 7 [ 4.1 ] ; p=0.23; lactate : 4.2 [ 3.3 ] vs. 4.2 [ 2.7 ] ; p=0.98). Intravenous enalaprilat did not exhibit any advantage compared to nitroglycerine in terms of blood pressure reduction or respiratory and metabolic parameters on admission to the emergency room . We conclude that enalaprilat is no substitute for nitroglycerine in the out-of-hospital treatment of hypertensive patients with pulmonary edema ." ], "offsets": [ [ 0, 2300 ] ] } ]	[ { "id": "ZfuerKardiologie.90880208.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "nitroglycerine" ], "offsets": [ [ 86, 100 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017887" } ] }, { "id": "ZfuerKardiologie.90880208.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "enalaprilat" ], "offsets": [ [ 117, 128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014027" } ] }, { "id": "ZfuerKardiologie.90880208.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 152, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.90880208.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 181, 189 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { 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"db_id": "C0005835" } ] }, { "id": "ZfuerKardiologie.90880208.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 265, 273 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerKardiologie.90880208.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 300, 305 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "ZfuerKardiologie.90880208.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 306, 314 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerKardiologie.90880208.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "pulmonary edema" ], "offsets": [ [ 195, 210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034063" } ] }, { "id": "ZfuerKardiologie.90880208.eng.abstr-s1-t14", "type": "umlsterm", "text": [ "blood pressure" ], "offsets": [ 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ZfuerKardiologie.90880215.eng.abstr	ZfuerKardiologie.90880215.eng.abstr	[ { "id": "ZfuerKardiologie.90880215.eng.abstr-passage-0", "type": "abstract", "text": [ "Most people with the Metabolic Syndrome die from thrombotic complications superimposed to degenerative arterial vascular lesions , mostly myocardial infarction . Type-2-Diabetes is a risk factor per se for such complications , but often clusters with dyslipoproteinemia , hypertension and obesity . This is referred to as \" Metabolic Syndrome \" and often operates on a genetically programmed susceptibility which accelerates the pathogenesis of coronary artery disease in front of a much wider diabetes specific cardiopathy . From a pathophysiological point of view none of these associated risk factors explains the pathogenetic series of events leading to the precipitation of an occlusive thrombus at sites of complicated coronary plaques . In patients with the Metabolic Syndrome the coagulation system is switched towards a prethrombotic state , involving increased plasmatic coagulation , diminished fibrinolysis , decreased endothelial thromboresistance and predominantly platelet hyperreactivity ( \" diabetic thrombocytopathy \" ) . Some of these factors are associated with an increased coronary risk ( e.g. fibrinogen , PAI-1, platelets ) , but are also directly linked to the pathogenesis of \" atherothrombosis \" . Altered cardiac remodelling together with adhesion and coagulation mechanisms appears suitable to explain decreased functional performance of infarcted organs , decreased success of acute ( reduced fibrinolytic response , no reflow phenomenon ) and longterm intervention strategies for vessel patency ( PTCA , CABG ) in Diabetes . Glucose adjustment alone will not adequately neutralize these complex mechanisms , but in the situation of myocardial infarction eumetabolization with parenteral glucose-insulin-potassium infusion appears mandatory similar to non-diabetics . On the longterm a multidimensional interventional repertoire is required particularly in patients with the Metabolic Syndrome including antihypertensive , antidyslipoproteinemic and antithrombotic drugs , customized according to the individual patients needs as assessed by early diagnostic measures ( \" early secondary prevention \" ) ." ], "offsets": [ [ 0, 2134 ] ] } ]	[ { "id": "ZfuerKardiologie.90880215.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "people" ], "offsets": [ [ 5, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027361" } ] }, { "id": "ZfuerKardiologie.90880215.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "Syndrome" ], "offsets": [ [ 31, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerKardiologie.90880215.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 60, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.90880215.eng.abstr-s1-t4", 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ZfuerKardiologie.90880225.eng.abstr	ZfuerKardiologie.90880225.eng.abstr	[ { "id": "ZfuerKardiologie.90880225.eng.abstr-passage-0", "type": "abstract", "text": [ "The case of a 57 year old patient is reported , who suffered from an acute myocardial infarction with maximum CK and CKMB values of 821 and 84 U/l , respectively . The patient underwent bicycle exercise testing 9 days after a myocardial infarction in 25 W steps every 2 min starting with 50 W. The ergometry was interrupted at 125 W because of ST segment depression of 0.28 mV in V6. Systolic blood pressure dropped to 55 mm Hg , combined with severe angina and shock . Volume substitution and catecholamines did not elevate blood pressure . Immediate M-mode and Doppler echo revealed a \" stiletto \" -shaped mitral regurgitation profile typical of acute mitral valve insufficiency . The transesophageal echocardiogram showed a distinct mass moving between the left ventricle and left atrium , diagnostic of papillary muscle rupture . Despite of shock , mitral valve replacement was performed successfully . To our knowledge , this is the first report of a papillary muscle rupture during exercise testing after myocardial infarction ." ], "offsets": [ [ 0, 1034 ] ] } ]	[ { "id": "ZfuerKardiologie.90880225.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "old" ], "offsets": [ [ 22, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "ZfuerKardiologie.90880225.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 26, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880225.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 86, 96 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880225.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "values" ], "offsets": [ [ 122, 128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "ZfuerKardiologie.90880225.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 75, 96 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] }, { "id": "ZfuerKardiologie.90880225.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 168, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880225.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "testing" ], "offsets": [ [ 203, 210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039593" } ] }, { "id": "ZfuerKardiologie.90880225.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 237, 247 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880225.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "ergometry" ], "offsets": [ [ 298, 307 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085143" } ] }, { "id": "ZfuerKardiologie.90880225.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "depression" ], "offsets": [ [ 355, 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The aim of our study was to evaluate treatment costs of patients with uncomplicated and complicated follow-up in order to evaluate the economic consequences of new therapeutic strategies , like the introduction of GPIIb/IIIa blockers at our hospital ." ], "offsets": [ [ 0, 375 ] ] } ]	[ { "id": "ZfuerKardiologie.90880261.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "aim" ], "offsets": [ [ 15, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0108800" } ] }, { "id": "ZfuerKardiologie.90880261.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "angina" ], "offsets": [ [ 30, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002962" } ] }, { "id": "ZfuerKardiologie.90880261.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 108, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.90880261.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Unstable angina" ], "offsets": [ [ 21, 36 ] ], "normalized": [ { 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ZfuerKardiologie.90880283.eng.abstr	ZfuerKardiologie.90880283.eng.abstr	[ { "id": "ZfuerKardiologie.90880283.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the study was the assessment of left ventricular ( LV ) systolic function and left ventricular mass following aortic valve replacement ( AVR ) due to aortic valve stenosis as well as the influence of regression of LV hypertrophy in patients with normal and impaired LV systolic function prior to surgery . 74 patients with severe aortic valve stenosis ( 29 female , 45 male , mean age 66 +/- 18 years ) were divided into 2 groups according to LV ejection fraction ( EF ) : Group 1 with EF > 50% ( n = 40 ) ; Group 2 with EF = 50% ( n = 34 ) . Furthermore , patients were differentiated into a group A without ( n = 53 ) and a group B with aortic regurgitation ( = II ° , n = 21 ) . All patients were examined by transthoracic echocardiography before and 1 month after surgery . There was a significant decrease of LV enddiastolic and endsystolic valume indices following AVR in group 2 and group B. Patients with preoperatively lower EF ( group 2 ) showed an increase in LV ejection fraction from 39 +/- 10% before AVR to 47 +/- 11% after AVR ( p 0.001 ) , whereas patients with preoperative normal EF ( group 1 ) showed a significant decrease in EF ( from 62 +/- 8% to 57 +/- 10% , p 0.05 ) . Also patients with combined aortic valve disease before AVR had an increase of EF after surgery ( from 45 %plusmn; 14% to 56 +/- 14% , p 0.03 ) . There were significant decreases of interventricular septum thickness and LV posterior wall thickness in group 1 and group A , whereas a significant decrease of LV anddiastolic diameter index was noted only in group B. Improvement of the NYHA functional class could be demonstrated in group 2 from 2.8 +/- 0.7 before to 2.2 +/- 0.6 after AVR , as well as in group B from 2.9 +/- 0.7 before to 1.9 +/- 0.7 after surgery . In conclusion , patients with impaired LV function or combined aortic valve disease showed a significant improvement of left ventricular systolic function after AVR , while patients with normal LV function presented a slight decrease of EF . There was a significant regression of left ventricular muscle mass in all groups independent of the left ventricular functional status ." ], "offsets": [ [ 0, 2150 ] ] } ]	[ { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "aim" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0108800" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "assessment" ], "offsets": [ [ 29, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028708" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "systolic" ], "offsets": [ [ 67, 75 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039155" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "function" ], "offsets": [ [ 76, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031843" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "stenosis" ], "offsets": [ [ 174, 182 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009814" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "regression" ], "offsets": [ [ 211, 221 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034979" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "hypertrophy" ], "offsets": [ [ 228, 239 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020564" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 243, 251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "systolic" ], "offsets": [ [ 280, 288 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039155" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "function" ], "offsets": [ [ 289, 297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031843" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 307, 314 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "aortic valve" ], "offsets": [ [ 121, 133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003501" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "aortic valve" ], "offsets": [ [ 161, 173 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003501" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t14", "type": "umlsterm", "text": [ "LV hypertrophy" ], "offsets": [ [ 225, 239 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0149721" } ] }, { "id": "ZfuerKardiologie.90880283.eng.abstr-s1-t15", "type": "umlsterm", "text": [ "aortic valve 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Magnetic resonance imaging identified a calcified thrombus in the apical cavity of the LV in the setting of an atypical HCM ." ], "offsets": [ [ 0, 799 ] ] } ]	[ { "id": "ZfuerKardiologie.90880290.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "hypertrophic" ], "offsets": [ [ 19, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020564" } ] }, { "id": "ZfuerKardiologie.90880290.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "cardiomyopathy" ], "offsets": [ [ 32, 46 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027049" } ] }, { "id": "ZfuerKardiologie.90880290.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "thrombus" ], "offsets": [ [ 79, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087086" } ] }, { "id": "ZfuerKardiologie.90880290.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "hypertrophic cardiomyopathy" ], "offsets": [ [ 19, 46 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007194" } ] }, { "id": "ZfuerKardiologie.90880290.eng.abstr-s2-t1", 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ZfuerKardiologie.90880296.eng.abstr	ZfuerKardiologie.90880296.eng.abstr	[ { "id": "ZfuerKardiologie.90880296.eng.abstr-passage-0", "type": "abstract", "text": [ "We report a case of LAD-stent deformation by extracorporeal cardiopulmonary resuscitation ( CPR ) shortly after stent implantation . To our knowledge , this is the first reported case ." ], "offsets": [ [ 0, 185 ] ] } ]	[ { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "LAD-stent" ], "offsets": [ [ 20, 29 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "resuscitation" ], "offsets": [ [ 76, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035273" } ] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "CPR" ], "offsets": [ [ 92, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007203" } ] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "stent" ], "offsets": [ [ 112, 117 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "implantation" ], "offsets": [ [ 118, 130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029976" } ] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "cardiopulmonary resuscitation" ], "offsets": [ [ 60, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007203" } ] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "knowledge" ], "offsets": [ [ 140, 149 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376554" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-r1-t6.1-t5.1", "type": "affects", "arg1_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t6", "arg2_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-r2-t6.1-t4.1", "type": "uses", "arg1_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t6", "arg2_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-r3-t3.1-t4.1", "type": "uses", "arg1_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t3", "arg2_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-r4-t2.1-t4.1", "type": "uses", "arg1_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t2", "arg2_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-r5-t2.1-t5.1", "type": "affects", "arg1_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t2", "arg2_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-r6-t3.1-t5.1", "type": "affects", "arg1_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t3", "arg2_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-r7-t2.1-t1.1", "type": "uses", "arg1_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t2", "arg2_id": "ZfuerKardiologie.90880296.eng.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-r8-t3.1-t1.1", "type": "uses", "arg1_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t3", "arg2_id": "ZfuerKardiologie.90880296.eng.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880296.eng.abstr-s1-r9-t6.1-t1.1", "type": "uses", "arg1_id": "ZfuerKardiologie.90880296.eng.abstr-s1-t6", "arg2_id": "ZfuerKardiologie.90880296.eng.abstr-s2-t1", "normalized": [] } ]
ZfuerKardiologie.90880305.eng.abstr	ZfuerKardiologie.90880305.eng.abstr	[ { "id": "ZfuerKardiologie.90880305.eng.abstr-passage-0", "type": "abstract", "text": [ "The extent of physical activity and the dynamic performance capacity show an inverse relationship to cardiovascular mortality , independent of the influence of other risk factors , but the underlying mechanism remains uncertain . Most concepts assume that the aerobic capacity of the peripheral musculature is increased by training , and thus improved cardiocirculatory regulation and especially a more favorable stress reaction pattern are attained . This adaptation is essentially an inverse adaptation mechanism as in established cardiocirculatory insufficiency ." ], "offsets": [ [ 0, 566 ] ] } ]	[ { "id": "ZfuerKardiologie.90880305.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 116, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 166, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "risk factors" ], "offsets": [ [ 166, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035648" } ] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "training" ], "offsets": [ [ 323, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040607" }, { "db_name": "UMLS", "db_id": "C0220931" } ] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "regulation" ], "offsets": [ [ 370, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034982" }, { "db_name": "UMLS", "db_id": "C0220905" } ] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "stress" ], "offsets": [ [ 413, 419 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "adaptation" ], "offsets": [ [ 457, 467 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000934" } ] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "adaptation" ], "offsets": [ [ 494, 504 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000934" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880305.eng.abstr-s2-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerKardiologie.90880305.eng.abstr-s3-t2", "arg2_id": "ZfuerKardiologie.90880305.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s2-r2-t2.1-t1.1", "type": "isa", "arg1_id": "ZfuerKardiologie.90880305.eng.abstr-s3-t2", "arg2_id": "ZfuerKardiologie.90880305.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s2-r3-t1.1-t1.2", "type": "associated_with", "arg1_id": "ZfuerKardiologie.90880305.eng.abstr-s3-t1", "arg2_id": "ZfuerKardiologie.90880305.eng.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s2-r4-t2.1-t2.2", "type": "isa", "arg1_id": "ZfuerKardiologie.90880305.eng.abstr-s3-t2", "arg2_id": "ZfuerKardiologie.90880305.eng.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s2-r5-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerKardiologie.90880305.eng.abstr-s3-t1", "arg2_id": "ZfuerKardiologie.90880305.eng.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerKardiologie.90880305.eng.abstr-s2-r6-t1.1-t2.2", "type": "isa", "arg1_id": "ZfuerKardiologie.90880305.eng.abstr-s3-t1", "arg2_id": "ZfuerKardiologie.90880305.eng.abstr-s2-t2", "normalized": [] } ]
ZfuerKardiologie.90880315.eng.abstr	ZfuerKardiologie.90880315.eng.abstr	[ { "id": "ZfuerKardiologie.90880315.eng.abstr-passage-0", "type": "abstract", "text": [ "Thrombus formation at the site of atherosclerotic lesions , especially on a ruptured plaque , plays a central role in the \" atherothrombosis \" hypothesis . An activation of the hemostasis and a disturbed fibrinolysis are known . These alterations are especially marked in patients with acute coronary syndromes ." ], "offsets": [ [ 0, 312 ] ] } ]	[ { "id": "ZfuerKardiologie.90880315.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Thrombus" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087086" } ] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "plaque" ], "offsets": [ [ 85, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011389" }, { "db_name": "UMLS", "db_id": "C0333463" } ] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 110, 114 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "hemostasis" ], "offsets": [ [ 177, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019116" } ] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "fibrinolysis" ], "offsets": [ [ 204, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016017" } ] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 272, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "syndromes" ], "offsets": [ [ 301, 310 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880315.eng.abstr-s1-r1-t1.1-t2.2", "type": "location_of", "arg1_id": "ZfuerKardiologie.90880315.eng.abstr-s3-t1", "arg2_id": "ZfuerKardiologie.90880315.eng.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s1-r2-t1.1-t2.2", "type": "result_of", "arg1_id": "ZfuerKardiologie.90880315.eng.abstr-s3-t1", "arg2_id": "ZfuerKardiologie.90880315.eng.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s1-r3-t2.2-t1.1", "type": "result_of", "arg1_id": "ZfuerKardiologie.90880315.eng.abstr-s1-t2", "arg2_id": "ZfuerKardiologie.90880315.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s1-r4-t2.2-t3.1", "type": "result_of", "arg1_id": "ZfuerKardiologie.90880315.eng.abstr-s1-t2", "arg2_id": "ZfuerKardiologie.90880315.eng.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s1-r5-t1.1-t3.1", "type": "result_of", "arg1_id": "ZfuerKardiologie.90880315.eng.abstr-s3-t1", "arg2_id": "ZfuerKardiologie.90880315.eng.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerKardiologie.90880315.eng.abstr-s3-r1-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerKardiologie.90880315.eng.abstr-s3-t2", "arg2_id": "ZfuerKardiologie.90880315.eng.abstr-s3-t1", "normalized": [] } ]
ZfuerKardiologie.90880324.eng.abstr	ZfuerKardiologie.90880324.eng.abstr	[ { "id": "ZfuerKardiologie.90880324.eng.abstr-passage-0", "type": "abstract", "text": [ "The importance of cell polarity as a fundamental biological principle is increasingly recognized in the cardiovascular system . Polar cell mechanisms underlie not only the development of the heart and blood vessels , but also play a major role in the adult organism for polarized endothelial functions such as the separation of the intra- and extravascular compartment and the vectorial exchange of substances between these compartments . Endothelial cells are connected through intercellular junctions which separate the functionally and structurally distinct luminal and abluminal cell surfaces . The luminal plasma membrane is in contact with the blood and takes part in the regulation of hemostasis . The abluminal cell membrane connects the endothelial cell with the basement membrane and modulates blood flow through the release of vasoactive substances . Results from epithelial model systems have shown that the polarized cell phenotype is generated by specific protein sorting and regulated protein trafficking between the trans-Golgi network and the cell surface . The polarized distribution of cell membrane proteins is maintained by anchorage with the cytoskeleton and limitation of lateral diffusion by tight junctions . Disturbances of cell polarity may contribute to the pathogenesis of disease states , including ischemic and radiocontrast-induced acute renal failure and carcinomas . Recent results have demonstrated the importance of cholesterol for protein traffic from the trans-Golgi network to the apical cell membrane . This novel intracellular function of cholesterol could point to a connection between cell polarity and the pathogenesis of arteriosclerosis . The polarity of the endothelium also has to be taken into account when developing gene-therapeutic strategies , since therapeutic success will not only depend on the efficient expression of the desired gene product , but also on its correct cellular location or secretion into the correct extracellular compartment . 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In this study we tested the hypothesis that patients with DCM and controls show a different behavior in the baroreflex ( BR ) regulation ." ], "offsets": [ [ 0, 304 ] ] } ]	[ { "id": "ZfuerKardiologie.90880331.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "analysis" ], "offsets": [ [ 4, 12 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 16, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 51, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 57, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 119, 127 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "cardiomyopathy" ], "offsets": [ [ 141, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027049" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "heart rate" ], "offsets": [ [ 16, 26 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018810" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "blood pressure" ], "offsets": [ [ 51, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005823" }, { "db_name": "UMLS", "db_id": "C0005824" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "dilated cardiomyopathy" ], "offsets": [ [ 133, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007193" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 210, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "controls" ], "offsets": [ [ 232, 240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243148" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "behavior" ], "offsets": [ [ 258, 266 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004927" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "baroreflex" ], "offsets": [ [ 274, 284 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206162" } ] }, { "id": "ZfuerKardiologie.90880331.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "BR" ], "offsets": [ [ 287, 289 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006222" } ] }, { "id": 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ZfuerKardiologie.90880363.eng.abstr	ZfuerKardiologie.90880363.eng.abstr	[ { "id": "ZfuerKardiologie.90880363.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Homografts for valve replacement are indicated in acute valve endocarditis . It is assumed that they possess anti-infective properties . Homografts are an established indication in aortic valve replacement . We present our early results with homografts for mitral valve replacement in acute endocarditis ." ], "offsets": [ [ 0, 320 ] ] } ]	[ { "id": "ZfuerKardiologie.90880363.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Homografts" ], "offsets": [ [ 15, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040739" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "endocarditis" ], "offsets": [ [ 77, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014118" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Homografts" ], "offsets": [ [ 152, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040739" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "aortic valve" ], "offsets": [ [ 196, 208 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003501" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "homografts" ], "offsets": [ [ 257, 267 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040739" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "endocarditis" ], "offsets": [ [ 306, 318 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014118" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "mitral valve" ], "offsets": [ [ 272, 284 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026264" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880363.eng.abstr-s1-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t2", "arg2_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s1-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t1", "arg2_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s3-r1-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t2", "arg2_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s4-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t2", "arg2_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s4-r2-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t3", "arg2_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s4-r3-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t1", "arg2_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s4-r4-t3.1-t2.1", "type": "location_of", "arg1_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t3", "arg2_id": "ZfuerKardiologie.90880363.eng.abstr-s4-t2", "normalized": [] } ]
ZfuerKardiologie.90880369.eng.abstr	ZfuerKardiologie.90880369.eng.abstr	[ { "id": "ZfuerKardiologie.90880369.eng.abstr-passage-0", "type": "abstract", "text": [ "Ventricular arrhythmias can both result from and cause myocardial dysfunction . We report a case of a two-year-old girl with ventricular tachycardia showing signs of heart failure consisting with a tachycardiomyopathy . The therapy with class I and class III antiarrhythmic drugs did not improve the cardiac situation significantly . The cardiologic investigations were consistent with the verapamilsensitive ventricular tachycardia in young adults . 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ZfuerKardiologie.90880394.eng.abstr	ZfuerKardiologie.90880394.eng.abstr	[ { "id": "ZfuerKardiologie.90880394.eng.abstr-passage-0", "type": "abstract", "text": [ "The leading pathophysiology of acute heart failure and cardiogenic shock is acute or subacute myocardial infarction . Reperfusion of the occluded coronary vessel accompanied by adequate support of cardiac function via assist systems , preferentially the intraaortic balloon counterpulsation , is the therapy of choice . Adjustment of preload ( high pulmonary capillary pressure in acute myocardial infarction with small heart , low pulmonary capillary wedge pressure in patients with large ventricles and chronic heart failure , high central venous pressure in patients with right heart failure , and right ventricle myocardial infarction ) and afterload ( peripheral arterial vasodilatation , recommended systolic arterial pressure 80-90 mm Hg ) but not maximization of cardiac output play an important role . Positive inotropic drugs should be considered when these strategies fail . In acute right heart failure in pulmonary hypertension , a preferential pulmonary vasodilatation with intravenous or inhalative prostaglandins or inhalative NO are of utmost importance . Systemic hypotension is not a contraindication in this pathophysiology ." ], "offsets": [ [ 0, 1145 ] ] } ]	[ { "id": "ZfuerKardiologie.90880394.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pathophysiology" ], "offsets": [ [ 12, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031847" } ] }, { "id": "ZfuerKardiologie.90880394.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 37, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880394.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "shock" ], "offsets": [ [ 67, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036974" } ] }, { "id": "ZfuerKardiologie.90880394.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 105, 115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880394.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "cardiogenic shock" ], "offsets": [ [ 55, 72 ] ], 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"type": "umlsterm", "text": [ "prostaglandins" ], "offsets": [ [ 1014, 1028 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033554" } ] }, { "id": "ZfuerKardiologie.90880394.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "pulmonary hypertension" ], "offsets": [ [ 918, 940 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020542" } ] }, { "id": "ZfuerKardiologie.90880394.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "hypotension" ], "offsets": [ [ 1082, 1093 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020649" } ] }, { "id": "ZfuerKardiologie.90880394.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "contraindication" ], "offsets": [ [ 1103, 1119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079164" } ] }, { "id": "ZfuerKardiologie.90880394.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "pathophysiology" ], "offsets": [ [ 1128, 1143 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031847" } ] } ]	[]	[]	[ { "id": 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The diagnostic arsenal of risk parameters comprised heart rate variability , baroreflex sensitivity , and more traditional markers such as non-sustained ventricular tachycardia , left ventricular ejection fraction , and ventricular late potentials . Patiens were followed for a mean of 33 +/- 21 months . Stepwise logistic regression analysis revealed that left ventricular function , both autonomic markers , and the patency of the infarct related artery were independent predictors of the prospectively defined primary study endpoint , i.e. , all-cause mortality plus ventricular tachyarrhythmic events . With respect to the secondary endpoint ( ventricular tachyarrhythmic events ) , left ventricular function , heart rate variability , and infarct vessel patency were independent predictors . Ventricular late potentials and nonsustained ventricular tachycardia had no predictive value with respect to ventricular tachyarrhythmic events . These findings from a large prospective long-term study demonstrate the value of markers of cardiac autonomic tone in identifying infarct survivors at risk for malignant ventricular tachyarrhythmias and sudden death ." ], "offsets": [ [ 0, 1874 ] ] } ]	[ { "id": "ZfuerKardiologie.90880400.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Prognosis" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033325" } ] }, { "id": "ZfuerKardiologie.90880400.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 13, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880400.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 49, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880400.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 38, 59 ] ], "normalized": [ { "db_name": "UMLS", 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"id": "ZfuerKardiologie.90880410.eng.abstr-s2-t13", "type": "umlsterm", "text": [ "blood gases" ], "offsets": [ [ 216, 227 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005800" } ] }, { "id": "ZfuerKardiologie.90880410.eng.abstr-s2-t14", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 273, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] }, { "id": "ZfuerKardiologie.90880410.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 374, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880410.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 388, 396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880410.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 363, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] } ]	[]	[]	[ { "id": 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ZfuerKardiologie.90880418.eng.abstr	ZfuerKardiologie.90880418.eng.abstr	[ { "id": "ZfuerKardiologie.90880418.eng.abstr-passage-0", "type": "abstract", "text": [ "There have been some prospective randomized studies which compared primary angioplasty with intravenous thrombolysis in patients with an acute myocardial infarction ( AMI ) . However , a substantial number of patients with AMI who would not have been included in those trials are treated with one of these two therapeutic options . To describe the proportions , characteristics , and outcome of these patients treated with primary angioplasty or thrombolysis we analyzed the data of the prospective \" Maximal Individual Optimized Therapy for Acute Myocardial Infarction \" ( MITRA ) trial ." ], "offsets": [ [ 0, 589 ] ] } ]	[ { "id": "ZfuerKardiologie.90880418.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "angioplasty" ], "offsets": [ [ 75, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162577" } ] }, { "id": "ZfuerKardiologie.90880418.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 120, 128 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880418.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 154, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880418.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "AMI" ], "offsets": [ [ 167, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] }, { "id": "ZfuerKardiologie.90880418.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 143, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] }, { "id": "ZfuerKardiologie.90880418.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 209, 217 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880418.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "AMI" ], "offsets": [ [ 223, 226 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] }, { "id": "ZfuerKardiologie.90880418.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 310, 321 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerKardiologie.90880418.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 401, 409 ] ], "normalized": [ { "db_name": "UMLS", 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ZfuerKardiologie.90880426.eng.abstr	ZfuerKardiologie.90880426.eng.abstr	[ { "id": "ZfuerKardiologie.90880426.eng.abstr-passage-0", "type": "abstract", "text": [ "The discrimination of supraventricular versus ventricular tachycardias by an implantable cardioverter-defibrillator ( ICD ) is still a remaining clinical problem . The false positive detection of supraventricular as ventricular tachycardias causes inadequate electrical therapies of the ICD . To improve the increase of specificity criterias like \" Onset \" or \" Stability \" are offered . If these criterias during tachycardia are not fulfilled , the \" sustained rate duration \" ( SRD ) is offered as a security criterion . The SRD reasons the delivery of the therapy during tachycardia after a programmable time ." ], "offsets": [ [ 0, 613 ] ] } ]	[ { "id": "ZfuerKardiologie.90880426.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "discrimination" ], "offsets": [ [ 4, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012632" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "tachycardias" ], "offsets": [ [ 58, 70 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039231" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "ventricular tachycardias" ], "offsets": [ [ 46, 70 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042514" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "implantable cardioverter-defibrillator" ], "offsets": [ [ 77, 115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162589" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "tachycardias" ], "offsets": [ [ 228, 240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039231" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "therapies" ], "offsets": [ [ 270, 279 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "ventricular tachycardias" ], "offsets": [ [ 216, 240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042514" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "specificity" ], "offsets": [ [ 320, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037791" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "tachycardia" ], "offsets": [ [ 414, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039231" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "criterion" ], "offsets": [ [ 511, 520 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243161" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "delivery" ], "offsets": [ [ 543, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 559, 566 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "tachycardia" ], "offsets": [ [ 574, 585 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039231" } ] }, { "id": "ZfuerKardiologie.90880426.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 607, 611 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] } ]	[]	[]	[ { 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Phase II : Postoperatively , 6 out of 20 patients ( 30 % ) developed 7 episodes of atrial fibrillation ( n=6) and atrial flutter ( n=1). In 5 patients , SVT could be converted to sinus rhythm ( n=5) or junctional rhythm ( n=1). The mean postoperative defibrillation threshold ( DFT ) was 2.7 +/- 2.1 J with a mean shock-impedance of 50.2 +/- 6.8 Ohms . In conclusion , the TAPE allows low-energy defibrillation of atrial fibrillation . It seems to be a useful alternative in the treatment of supraventricular tachycardia ." ], "offsets": [ [ 0, 1233 ] ] } ]	[ { "id": "ZfuerKardiologie.90880434.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "tachycardia" ], "offsets": [ [ 17, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039231" } ] }, { "id": "ZfuerKardiologie.90880434.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "complication" ], "offsets": [ [ 49, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.90880434.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 82, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.90880434.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Supraventricular tachycardia" ], "offsets": [ [ 0, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039240" } ] }, { "id": "ZfuerKardiologie.90880434.eng.abstr-s1-t5", 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ZfuerKardiologie.90880467.eng.abstr	ZfuerKardiologie.90880467.eng.abstr	[ { "id": "ZfuerKardiologie.90880467.eng.abstr-passage-0", "type": "abstract", "text": [ "The Brugada-Brugada syndrome is a rhythmologic disorder which can be diagnosed because of typical ECG criteria . A high-take off descending ST segment localized to the right chest leads , associated with right bundle branch block and ventricular fibrillation or syncopes are characteristic of the syndrome . ECG alterations in the right precordial leads were recorded in a 47 year old female patient who was admitted to hospital because of enteritis and associated syncope . The ECG alterations were initally not realized as Brugada-Brugada syndrome . Because of \" recognizing \" comparable ECG alterations during a congress lecture , the diagnosis was made . The patient was treated with an ICD ." ], "offsets": [ [ 0, 696 ] ] } ]	[ { "id": "ZfuerKardiologie.90880467.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "syndrome" ], "offsets": [ [ 20, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerKardiologie.90880467.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "disorder" ], "offsets": [ [ 47, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880467.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "ECG" ], "offsets": [ [ 98, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013798" } ] }, { "id": "ZfuerKardiologie.90880467.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "criteria" ], "offsets": [ [ 102, 110 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243161" } ] }, { "id": "ZfuerKardiologie.90880467.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "right" ], "offsets": [ [ 168, 173 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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ZfuerKardiologie.90880473.eng.abstr	ZfuerKardiologie.90880473.eng.abstr	[ { "id": "ZfuerKardiologie.90880473.eng.abstr-passage-0", "type": "abstract", "text": [ "25 patients with coronary heart disease ( CHD , 62 +/- 9 years ) and 18 subjects free from cardiovascular disease ( 28 +/- 9 years ) were tested on a cycle ergometer using a graded incremental test protocol : a ) in the common upright position , b ) as dynamic stress echocardiography in a semi-supine position . Whereas no relevant differences could be detected between the two conditions for the healthy subjects concerning heart rate , blood pressure , and rate-pressure product ( 2 x 3 ANOVA , t-test with -adjustment ) , the CHD patients showed both significantly higher heart rates as well as a significantly higher rate-pressure product ( 50 W : 15 300 +/- 2973 mmHg/min vs. 13 822 +/- 3042 mmHg/min ; 75 W : 18 028 +/- 3479 mmHg/min vs 16 337 +/- 2619 mmHg/min ) on equivalent stages during stress echocardiography if compared to the sitting position . There were no differences for systolic blood pressure in this group ; the diastolic values were higher in the sitting position at rest and during 50 W. Lactate concentrations ( determined only in the healthy subjects ) were significantly higher on all stages during dynamic stress echocardiography . The workload at the individual anaerobic threshold ( IAT ) was significantly lower ." ], "offsets": [ [ 0, 1245 ] ] } ]	[ { "id": "ZfuerKardiologie.90880473.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 3, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 26, 31 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 32, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 106, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "test" ], "offsets": [ [ 193, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0076174" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "stress" ], "offsets": [ [ 261, 267 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "heart disease" ], "offsets": [ [ 26, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018799" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "cardiovascular disease" ], "offsets": [ [ 91, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007222" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "coronary heart disease" ], "offsets": [ [ 17, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010068" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 426, 431 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "blood" ], "offsets": [ [ 439, 444 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" }, { "db_name": "UMLS", "db_id": "C0005835" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 445, 453 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "rate-pressure" ], "offsets": [ [ 460, 473 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "ANOVA" ], "offsets": [ [ 490, 495 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002780" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "-adjustment" ], 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"offsets": [ [ 799, 805 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "heart rate" ], "offsets": [ [ 426, 436 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018810" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s2-t13", "type": "umlsterm", "text": [ "blood pressure" ], "offsets": [ [ 439, 453 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005823" }, { "db_name": "UMLS", "db_id": "C0005824" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s2-t14", "type": "umlsterm", "text": [ "heart rates" ], "offsets": [ [ 576, 587 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018810" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "systolic" ], "offsets": [ [ 891, 899 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039155" } ] }, { "id": "ZfuerKardiologie.90880473.eng.abstr-s3-t2", "type": "umlsterm", "text": [ 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To expand the benefits of the MIDCAB concept to patients with multivessel disease , new interdisciplinary approaches have recently been introduced ." ], "offsets": [ [ 0, 657 ] ] } ]	[ { "id": "ZfuerKardiologie.90880481.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "direct" ], "offsets": [ [ 32, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0700157" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 48, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "grafting" ], "offsets": [ [ 73, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040732" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "minithoracotomy" ], "offsets": [ [ 145, 160 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039991" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "elderly" ], "offsets": [ [ 233, 240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 257, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "single" ], "offsets": [ [ 271, 277 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087136" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "vessel" ], "offsets": [ [ 278, 284 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005847" }, { "db_name": "UMLS", "db_id": "C0148346" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 285, 292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "coronary artery bypass" ], "offsets": [ [ 39, 61 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010055" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "procedure" ], "offsets": [ [ 310, 319 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 372, 379 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "minithoracotomy" ], "offsets": [ [ 392, 407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039991" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 419, 427 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "anterior" ], "offsets": [ [ 445, 453 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032008" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "posterior" ], "offsets": [ [ 468, 477 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032009" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "vessels" ], "offsets": [ [ 478, 485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005847" }, { "db_name": "UMLS", "db_id": "C0148346" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 501, 506 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880481.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 557, 565 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { 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ZfuerKardiologie.90880489.eng.abstr	ZfuerKardiologie.90880489.eng.abstr	[ { "id": "ZfuerKardiologie.90880489.eng.abstr-passage-0", "type": "abstract", "text": [ "Although there are randomized data for CABG vs. medical therapy and CABG vs. PTCA in primary therapy of CAD , there is few evidence on the appropriate therapy of recurrent angina after prior CABG . We analyzed data from 1265 consecutive patients ( PTS . ) presenting for recurrent angina after previous CABG who required either re-CABG ( n=67), PTCA ( n=768) or medical therapy alone ( medRx ) ( n=430) at our institution during 1986 through 1996. Outcome after index therapy is monitored during 45 +/- 34 months . The 3 therapeutic groups were similar with respect to gender ( 84 % male ) , age at therapy ( 60 years ) , prevalence of diabetes ( 22 % ) , and time to first ischemic event after primary CABG ( 37 months ) . Actuarial survival was significantly higher in the PTCA-group at 1 , 5 and 10 years after therapy of recurrent angina , despite the freedom from subsequent re-intervention was significantly lower ( 1-year-survival 95 % [ 37 % ] vs. 95 % [ 3 ] medRx vs. 79 % [ 4 % ] re-CABG , 5-year-survival 87 % [ 57 % ] vs 78 % [ 17 % ] medRx vs. 50 % [ 4 % ] re-CABG and 10-year-survival 72 % [ 65 % ] vs. 63 % [ 31 % ] medRx vs. 50 % [ 15 % ] re-CABG resp. , p 0.0001 , [ numbers in brackets represent corresponding values for incidence of re-intervention , p 0.0001 ] ) . These findings were similar after adjustment for different baseline characteristics ." ], "offsets": [ [ 0, 1370 ] ] } ]	[ { "id": "ZfuerKardiologie.90880489.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 56, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.90880489.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "PTCA" ], "offsets": [ [ 77, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002997" } ] }, { "id": "ZfuerKardiologie.90880489.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 93, 100 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.90880489.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "CAD" ], "offsets": [ [ 104, 107 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0170509" }, { "db_name": "UMLS", "db_id": "C0010068" } ] }, { 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ZfuerKardiologie.90880498.eng.abstr	ZfuerKardiologie.90880498.eng.abstr	[ { "id": "ZfuerKardiologie.90880498.eng.abstr-passage-0", "type": "abstract", "text": [ "Despite considerable progress in the knowledge about pathophysiology of cardiac allograft vascular disease ( CAVD ) , only few systematic studies are available , characterizing the natural course during long-term follow-up after heart transplantation ( HTX ) . Therefore , we analyzed in 354 heart transplant recipients ( 305 male , 45.9 +/- 11.2 years , mean observation period 5.8 +/- 3.0 years , range 0.9-12,4 years ) the results of 1129 coronary angiograms under the aspects of development , severity , localization , and progression of disease related to the prognosis of patients ." ], "offsets": [ [ 0, 588 ] ] } ]	[ { "id": "ZfuerKardiologie.90880498.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "knowledge" ], "offsets": [ [ 37, 46 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376554" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pathophysiology" ], "offsets": [ [ 53, 68 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031847" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 99, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s1-t4", "type": 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}, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 292, 297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "transplant" ], "offsets": [ [ 298, 308 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "male" ], "offsets": [ [ 326, 330 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024554" }, { "db_name": "UMLS", "db_id": "C0086582" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "observation" ], "offsets": [ [ 360, 371 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302523" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "period" ], "offsets": [ [ 372, 378 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025344" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "angiograms" ], "offsets": [ [ 451, 461 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002978" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 483, 494 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243107" }, { "db_name": "UMLS", "db_id": "C0020119" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 542, 549 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "prognosis" ], "offsets": [ [ 565, 574 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033325" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 578, 586 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t11", "type": "umlsterm", "text": [ "heart transplant" ], "offsets": [ [ 292, 308 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018823" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t12", "type": "umlsterm", "text": [ "transplant recipients" ], "offsets": [ [ 298, 319 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376387" } ] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s2-t13", "type": "umlsterm", "text": [ "coronary angiograms" ], "offsets": [ [ 442, 461 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085532" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880498.eng.abstr-s1-r1-t6.3-t6.1", "type": "associated_with", "arg1_id": "ZfuerKardiologie.90880498.eng.abstr-s1-t6", "arg2_id": "ZfuerKardiologie.90880498.eng.abstr-s2-t6", "normalized": [] }, { "id": "ZfuerKardiologie.90880498.eng.abstr-s1-r2-t2.1-t6.1", "type": "associated_with", "arg1_id": 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Progressive thrombosis of the false lumen ( FL ) occurred in 76 % of patients but complete thrombosis of the FL occurred in only 6 % of type I ca , 18 % type III ca but in 84 % of type III nc patients ." ], "offsets": [ [ 0, 997 ] ] } ]	[ { "id": "ZfuerKardiologie.90880507.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "aim" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0108800" } ] }, { "id": "ZfuerKardiologie.90880507.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "serial" ], "offsets": [ [ 16, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031082" } ] }, { "id": "ZfuerKardiologie.90880507.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 70, 78 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880507.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "dissection" ], "offsets": [ [ 99, 109 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012737" } ] }, { "id": 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ZfuerKardiologie.90880514.eng.abstr	ZfuerKardiologie.90880514.eng.abstr	[ { "id": "ZfuerKardiologie.90880514.eng.abstr-passage-0", "type": "abstract", "text": [ "Interventional duct occlusion is increasingly performed with detachable coils . In a series of 33 patients ( 34 procedures ) , we consistently used Gianturco-coils which were the initially employed coils . They are not securable but can be implanted in a simple manner . The rate of embolization was high ( 28 % ) in the first 14 procedures ; however , it declined to 5 % in the last 20 patients . We modified the technique by partially blocking the duct , when necessary , with a catheter which was advanced from the pulmonary artery and by implanting up to three coils . There was only one embolization and one small residual shunt in the last 20 patients . The mean fluoroscopy time in these patients was 11.0 +/- 5.8 minutes and decreased to 7.0 +/- 3.2 minutes in the last 10 patients with successful closure . Considering our experience , we continue to recommend the use of Gianturco-coils especially in the small duct which can be closed quickliy at low cost ." ], "offsets": [ [ 0, 968 ] ] } ]	[ { "id": "ZfuerKardiologie.90880514.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 98, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880514.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 112, 122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.90880514.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "embolization" ], "offsets": [ [ 283, 295 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013931" } ] }, { "id": "ZfuerKardiologie.90880514.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 330, 340 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { 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ZfuerKardiologie.90880521.eng.abstr	ZfuerKardiologie.90880521.eng.abstr	[ { "id": "ZfuerKardiologie.90880521.eng.abstr-passage-0", "type": "abstract", "text": [ "A 70-year-old woman with severely symptomatic hypertrophic obstructive cardiomyopathy was unresponsive to drug treatment . She had recurrent ventricular tachyarrhythmias and syncope and was at high risk for sudden death ; a dual chamber pacemaker defibrillator ( DDD-ICS ) was implanted . Her initial left ventricular outflow tract gradient was 80 mmHg and fell to 40 mmHg during dual-chamber pacing at an atrial ventricular delay of 140 ms . In the follow-up over six months she was asymptomatic with respect to angina pectoris ; ventricular tachycardias could be successfully terminated by antitachycardia pacing or by shocks . A dual chamber pacemaker defibrillator is an important therapeutic option for patients with symptomatic hypertrophic obstructive cardiomyopathy and ventricular tachyarrhythmias ." ], "offsets": [ [ 0, 808 ] ] } ]	[ { "id": "ZfuerKardiologie.90880521.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "woman" ], "offsets": [ [ 14, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "hypertrophic" ], "offsets": [ [ 46, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020564" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cardiomyopathy" ], "offsets": [ [ 71, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027049" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 106, 110 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": 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"db_name": "UMLS", "db_id": "C0039070" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 198, 202 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "death" ], "offsets": [ [ 214, 219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "pacemaker" ], "offsets": [ [ 237, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030163" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "sudden death" ], "offsets": [ [ 207, 219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011071" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "pacing" ], "offsets": [ [ 393, 399 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0287990" }, { "db_name": 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ZfuerKardiologie.90880529.eng.abstr	ZfuerKardiologie.90880529.eng.abstr	[ { "id": "ZfuerKardiologie.90880529.eng.abstr-passage-0", "type": "abstract", "text": [ "We report on a patient in whom a restenosis after two PTCA procedures was treated with directional coronary atherectomy . In the second DCA maneuvre a spiral dissection , type D , developed from ostium to restenosis with a balloon shaped part in the wall of the aorta ascendens . This part disappeared nearly completely by next day . The dissection in the right coronary artery persisted three months later until a bypass operation and was not visible after two years ." ], "offsets": [ [ 0, 469 ] ] } ]	[ { "id": "ZfuerKardiologie.90880529.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 15, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880529.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "PTCA" ], "offsets": [ [ 54, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002997" } ] }, { "id": "ZfuerKardiologie.90880529.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 59, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.90880529.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "atherectomy" ], "offsets": [ [ 108, 119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162513" } ] }, { "id": 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ZfuerKardiologie.90880550.eng.abstr	ZfuerKardiologie.90880550.eng.abstr	[ { "id": "ZfuerKardiologie.90880550.eng.abstr-passage-0", "type": "abstract", "text": [ "Arrhythmogenic right ventricular cardiomyopathy ( ARVC ) is a heart muscle disease of unknown cause . It can cause both cardiac arrrhythmia and heart failure or sudden death . As such patients typically will present to one of three groups depending upon the symptoms at presentation : the pathologist , the physician or the arrhythmologist . Typically a young patient who presents with presyncope or syncope may be investigated by an electrophysiologist and have ventricular tachyarrhythmias . Sadly some young individuals with ARVC may present to a pathologist with sudden cardiac death . Those that survive repeated bouts off arrhythmia and/or some individuals with primary heart failure may initially present to general physicians/cardiologists ." ], "offsets": [ [ 0, 749 ] ] } ]	[ { "id": "ZfuerKardiologie.90880550.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "right" ], "offsets": [ [ 15, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035621" } ] }, { "id": "ZfuerKardiologie.90880550.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "cardiomyopathy" ], "offsets": [ [ 33, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027049" } ] }, { "id": "ZfuerKardiologie.90880550.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 62, 67 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880550.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "muscle" ], "offsets": [ [ 68, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "ZfuerKardiologie.90880550.eng.abstr-s1-t5", 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ZfuerKardiologie.90880559.eng.abstr	ZfuerKardiologie.90880559.eng.abstr	[ { "id": "ZfuerKardiologie.90880559.eng.abstr-passage-0", "type": "abstract", "text": [ "From February 1991 to May 1998 , 340 patients had a cardioverter/defibrillator ( ICD ) implanted . Mean age was 64 +/- 9 years , 278 male and 62 female . 60% of patients had coronary artery disease and 31% dilative cardiomyopathy . Ejection fraction was 38 +/- 14% . The indication for an implantable cardioverter/defibrillator was in 57% of patients ventricular tachycardia , in 43% ventricular fibrillation . 298 patients had a single-chamber cardioverter/defibrillator implanted , 42 patients a dual-chamber cardioverter/defibrillator . In 25 patients additional subcutaneous patch or array electrodes and in 2 patients additional epicardial patch electrodes were implanted . Implantation site was in 92 patients abdominal and in 248 pectoral . Over a period of 7 years 34 lead-related complications occured in 33 patients ( 9.7% ) , after a median of 2 months after implantation . Diagnosis was made by routine chest x-ray in about 55% of lead-related complications , by clinical presentation ( inadequate therapy , pain ) in 24% , and by electrical parameters in 21% . In patients with an abdominal implantation site , lead-related complications occurred in 20% , in contrast to 6% in patients with a pectoral implantation site . Regarding patients with pectoral implantation site , lead-related complications were observed in 12% of patients with a dual-chamber ICD vs 4% with a single-chamber ICD ( p = 0.05 ) , due to dislocation of atrial electrodes with dual-chamber ICD . 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ZfuerKardiologie.90880574.eng.abstr	ZfuerKardiologie.90880574.eng.abstr	[ { "id": "ZfuerKardiologie.90880574.eng.abstr-passage-0", "type": "abstract", "text": [ "Due to the limited efficacy of drug therapy in atrial fibrillation and the high rate of recurrence , strong efforts were made to find non-pharmacological strategies . For three years now , the implantable atrial defibrillator Metrix from InControl has been available as an alternative therapy . From October 1995 to the present the atrial defibrillator was implanted in 179 patients worldwide . The sensitivity of the system and its algorithms to detect atrial fibrillation is 90% ; the specifity to detect sinus rhythm is 100% . In 121 of 179 patients , 748 episodes of spontaneous atrial fibrillation were treated with 2.4 shocks per episode . No proarrhythmic event or stroke was seen . A cardioversion to sinus rhythm could be achieved in 95% of patients ; the overall clinical success rate was 88% . In 7% of all patients , early recurrence of atrial fibrillation ( ERAF ) occurred that could not be converted into stable sinus rhythm after further cardioversions and antiarrhythmic therapy . In 4.1% there were lead-related complications , in 4 patients the device had to be explanted because of ineffective therapy , and in 3 patients the device had to be changed because of loss of telemetry or early depletion of battery . In 8 patients , postoperative complications were seen ( infections , pneumothorax and thrombosis of the subclavian vein ) . Overall , the implantable atrial defibrillator Metrix is an effective and safe alternative in treating atrial fibrillation ." ], "offsets": [ [ 0, 1480 ] ] } ]	[ { "id": "ZfuerKardiologie.90880574.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 31, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "ZfuerKardiologie.90880574.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 36, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.90880574.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "recurrence" ], "offsets": [ [ 88, 98 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034897" } ] }, { "id": "ZfuerKardiologie.90880574.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "efforts" ], "offsets": [ [ 108, 115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015264" } ] }, { "id": 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ZfuerKardiologie.90880631.eng.abstr	ZfuerKardiologie.90880631.eng.abstr	[ { "id": "ZfuerKardiologie.90880631.eng.abstr-passage-0", "type": "abstract", "text": [ "Aims : The flow convergence method enables the determination of flow across restrictive orifices . It was validated for planar orifice plates and atrioventricular valves . However , its quantitative application to aortic regurgitation is complicated due to the complex valve anatomy which distorts the converging flow field . An open angle formed by the leaflets causes relatively lower velocities in the region near the orifice , resulting in underestimation of flow . Confinement of the flow convergence region by the ascending aorta relatively increases the velocities at greater distance to the orifice and can cause overestimation of flow . We hypothesized that there is a region at intermediate distance to the orifice , where both these effects on the flow field are minimal , so that the local velocity there is only a function of flow . Methods and results : In a flow model , aortic regurgitation was simulated . The flow convergence was imaged by color Doppler . Different scanning directions were used ( analogue to apical and parasternal approach ) . Velocity profiles across the flow convergence were read along the line from the scanhead to the orifice . At a distance of 7 mm to the orifice , a uniform value was found for the ratio of local velocity v ( 7 mm ) /flow ( =0 . 28cm-2). Variations in size ( 3.5 to 7 mm ) , site ( central versus lateral ) and leaflet angle ( planar versus inverted funnel ) of the orifice and in the scanning approach had only a minimal effect on this value . Conclusion : The aortic regurgitant flow convergence is characterized by a relatively uniform V ( 7 mm ) /Q. Independent of variations in the anatomy and the scanning approach , this value directly reflects flow ." ], "offsets": [ [ 0, 1720 ] ] } ]	[ { "id": "ZfuerKardiologie.90880631.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "method" ], "offsets": [ [ 28, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.90880631.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "determination" ], "offsets": [ [ 47, 60 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerKardiologie.90880631.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "plates" ], "offsets": [ [ 135, 141 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005971" } ] }, { "id": "ZfuerKardiologie.90880631.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "anatomy" ], "offsets": [ [ 275, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220784" }, { "db_name": "UMLS", "db_id": "C0002808" } ] }, { "id": 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ZfuerKardiologie.90880647.eng.abstr	ZfuerKardiologie.90880647.eng.abstr	[ { "id": "ZfuerKardiologie.90880647.eng.abstr-passage-0", "type": "abstract", "text": [ "Atrial fibrillation is in 20-50% the most frequent dysrhythmia after coronary artery bypass grafting ( CABG ) and a possible cause for hemodynamical complications and prolongation off the medical treatment in patients . Therefore , the effect of -blocking with metoprolol for prevention of supraventricular arrhythmias ( SVA ) was investigated in a prospective and randomized trial . 200 patients after CABG were randomized in a drug and control group ( average age 63.2 years , 154 male , 46 female ) . Patients of the drug group ( n=100) were treated with metoprolol ( 1mg/kg/BW) beginning on day one after operation , whereas patients of the control group ( n=100) received therapy only in case of occurrence of atrial fibrillaton . ECG , blood pressure , and electrolyte concentrations were measured regulary until the tenth day after surgery . Reasons for exclusion were an ejection fraction ( 30% , SA- and AV-block or simultaneous application of epinephrine and metoprolol . There were no significant differences between the patients of drug and control group with respect to age , sex ejection fraction , previous medication , number and type of bypass grafts , cardiopulmonary bypass time , and perioperative ischemic events . However , a statistically significant difference was seen in the occurrence of supraventricular arrhythmias in both groups , 4 patients of the therapy group ( 4% ) in contrast to 37 patients of the control ( 37% ) developed supraventricular arrhythmias during the postoperative observation period ( p 0.0001 ) . Both groups differed in total time of hospital stay by 1.5 days ( control group : 9.83 +/- 2.88 days ; drug group : 8.42 +/- 2.81 days ) , which was statistically significant ( p 0.05 ) . All patients of the drug group could be discharged with a stable sinusrhythm , whereas 7 patients of the control group were discharged with persistent atrial fibrillation . The difference was statistically significant as well ( p 0.01 ) . Neither typical side effects of metoprolol , nor AV-blocks , bradycardia ( f 60/min) or symptoms of low blood pressure could be observed . The conclusion of this trial is a recommendation for a preventive application of 50mg metoprolol/day after coronary artery bypass surgery , which can reduce the incidence of SVA as well as the hospital stay statistically significant ." ], "offsets": [ [ 0, 2348 ] ] } ]	[ { "id": "ZfuerKardiologie.90880647.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "dysrhythmia" ], "offsets": [ [ 51, 62 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003811" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 78, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cause" ], "offsets": [ [ 125, 130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 149, 162 ] ], "normalized": [ { "db_name": 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ZfuerKardiologie.90880653.eng.abstr	ZfuerKardiologie.90880653.eng.abstr	[ { "id": "ZfuerKardiologie.90880653.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the present study was to assess the effects of carvedilol therapy in addition to conventional heart failure therapy on heart rate variability ( HRV ) and on left ventricular function in 14 patients with mild to moderate heart failure due to idiopathic dilated cardiomyopathy ( IDC ) . After a 3- to 4-week titration period , carvedilol was titrated up to 50mg daily , or the highest dose tolerated ( at least 25mg daily ) . Maintenance treatment was then continued for 8 weeks . Digital 24-hour Holter recordings were obtained at baseline and after 8 weeks of carvedilol therapy . HRV for the entire 24-hour period was computed in the time domain using the Oxford Medilog Excel 2 analysis system . Measures of HRV included the mean of all coupling intervals between normal beats ( RRm ) , the standard deviation of all normal RR intervals ( SDNN ) , the square root of the mean of the squared differences between adjacent normal RR intervals ( rMSSD ) , and the proportion of adjacent normal RR intervals differing > 50ms ( pNN50)." ], "offsets": [ [ 0, 1042 ] ] } ]	[ { "id": "ZfuerKardiologie.90880653.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "aim" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0108800" } ] }, { "id": "ZfuerKardiologie.90880653.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "carvedilol" ], "offsets": [ [ 58, 68 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0054836" } ] }, { "id": "ZfuerKardiologie.90880653.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 69, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": 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"ZfuerKardiologie.90880653.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 231, 236 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880653.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "cardiomyopathy" ], "offsets": [ [ 271, 285 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027049" } ] }, { "id": "ZfuerKardiologie.90880653.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "heart rate" ], "offsets": [ [ 130, 140 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018810" } ] }, { "id": "ZfuerKardiologie.90880653.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "ventricular function" ], "offsets": [ [ 173, 193 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0080309" } ] }, { "id": "ZfuerKardiologie.90880653.eng.abstr-s1-t13", "type": "umlsterm", "text": [ "dilated cardiomyopathy" ], "offsets": [ [ 263, 285 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007193" } ] }, { "id": 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ZfuerKardiologie.90880661.eng.abstr	ZfuerKardiologie.90880661.eng.abstr	[ { "id": "ZfuerKardiologie.90880661.eng.abstr-passage-0", "type": "abstract", "text": [ "The treatment of carotid stenoses with balloon angioplasty and stenting is a new and not generally established method ." ], "offsets": [ [ 0, 119 ] ] } ]	[ { "id": "ZfuerKardiologie.90880661.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 4, 13 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.90880661.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "angioplasty" ], "offsets": [ [ 47, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162577" } ] }, { "id": "ZfuerKardiologie.90880661.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "method" ], "offsets": [ [ 111, 117 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.90880661.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "balloon angioplasty" ], "offsets": [ [ 39, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002996" } ] } ]	[]	[]	[]
ZfuerKardiologie.90880669.eng.abstr	ZfuerKardiologie.90880669.eng.abstr	[ { "id": "ZfuerKardiologie.90880669.eng.abstr-passage-0", "type": "abstract", "text": [ "The flow directed balloon-tipped pulmonary artery catheter introduced by Swann and Ganz 1970 has made possible the measurement of filling pressures in the heart and is extensively used in operating rooms , in catheterization laboratories and in intensive care units . The rupture of the pulmonary artery is an uncommon complication associated with a high mortality rate exceeding 50 percent . Main symptoms are cough , hemoptysis , dyspnea and cardiac shock . Complications occur if guidelines for the safe use of the balloon-tipped catheters are not strictly followed : Excessive catheter manipulation , advancing the catheter tip too far peripherally and leaving the inflated balloon in the wedge position for long periods should be avoided . Patients with pulmonary hypertension as well as elderly and anticoagulated patients are at greater risk ." ], "offsets": [ [ 0, 850 ] ] } ]	[ { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 43, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "catheter" ], "offsets": [ [ 50, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085590" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "measurement" ], "offsets": [ [ 115, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242485" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "pressures" ], "offsets": [ [ 138, 147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "heart" ], 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ZfuerKardiologie.90880675.eng.abstr	ZfuerKardiologie.90880675.eng.abstr	[ { "id": "ZfuerKardiologie.90880675.eng.abstr-passage-0", "type": "abstract", "text": [ "A 49 year old male developed cardiocirculatory arrest following laparoscopic surgery of an inguinal hernia . Cardiopulmonary resuscitation ( CPR ) was started . The primary ECG showed ventricular fibrillation , after defibrillation a tachyarrhythmia and a newly developed right bundle branch block were documented . In addition , ST-elevations were seen in the left precordial leads . After 20 min of CPR the circulation was reestablished with high doses of catecholamines . Transthoracic echocardiography demonstrated a 7 mm pericardial effusion with mild impression of the right ventricular free wall . The patient underwent urgent heart catheterization for suspected pulmonary embolism ( differential diagnosis : acute myocardial infarction ) . Pulmonary angiography demonstrated floating thrombi in the left main pulmonary artery , which could be fragmented using a pigtail catheter . Pulmonary angiography was followed by coronary angiography , which demonstrated a sharply interrupted left anterior descending artery ( LAD ) , while the coronary arteries in general were found to be regular . The history , the morphology of the LAD-interruption , the concomitant pericardial effusion and the sternal and rib fractures were consistent with a type III coronary perforation in the classification of Sutton and Ellis . As contrast medium penetration into the pericardial space persisted after recanalization of the LAD , a 19 mm stent graft ( Jostent ) was used for closure . These grafts are constructed using a sandwich technique with an ultrathin layer of expandable polytetrafluorethylene being placed between two stents . After implantation of the stent graft no more contrast medium penetration was documented ." ], "offsets": [ [ 0, 1720 ] ] } ]	[ { "id": "ZfuerKardiologie.90880675.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "old" ], "offsets": [ [ 10, 13 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "ZfuerKardiologie.90880675.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "male" ], "offsets": [ [ 14, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024554" }, { "db_name": "UMLS", "db_id": "C0086582" } ] }, { "id": "ZfuerKardiologie.90880675.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 77, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.90880675.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "hernia" ], "offsets": [ [ 100, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019270" } ] }, { "id": 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ZfuerKardiologie.90880773.eng.abstr	ZfuerKardiologie.90880773.eng.abstr	[ { "id": "ZfuerKardiologie.90880773.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the study was to compare the mean and maximum flow and the flow pattern of coronary vein grafts ( SVG ) supplying target vessels of the inferior and lateral wall with internal mammary ( IMA ) grafts to the left anterior descending artery ( LAD ) . In 21 patients 25 bypass grafts ( 13/25 SVG , 12/25 IMA ) were investigated . Using the transit time ultrasound method , flow was measured every 5 ms and the flow data of 60 s were acquired . The flow pattern showed significant differences between both graft types during their cycle . IMA grafts showed only one peak occurring after 22.1 +/- 12.3% and the second after 63.4 +/- 15.5% of their cycle . The mean flow was not different in both graft types ( IMA : 45.3 +/- 27.0 ml/min and SVG : 41.8 +/- 26.7 ml/min , p = n . s. ) as it was the case for the maximum flow ( IMS : 98.4 +/- 45.2 ml/min and SVG : 75.7 +/- 55.4 ml/min , p = n . s. ) . In conclusion , there is a different flow pattern for both graft types concerning the number and the occurrence of flow-peaks in the bypass cycle . The mean and peak flow showed no significant difference ." ], "offsets": [ [ 0, 1110 ] ] } ]	[ { "id": "ZfuerKardiologie.90880773.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "aim" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0108800" } ] }, { "id": "ZfuerKardiologie.90880773.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "vein" ], "offsets": [ [ 95, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042449" } ] }, { "id": "ZfuerKardiologie.90880773.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "grafts" ], "offsets": [ [ 100, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0332835" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerKardiologie.90880773.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "vessels" ], "offsets": [ [ 132, 139 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005847" }, { "db_name": "UMLS", "db_id": "C0148346" } ] }, { "id": "ZfuerKardiologie.90880773.eng.abstr-s1-t5", "type": "umlsterm", 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The number of publications of successful percutaneous intervention in unprotected left main coronary stenosis is increasing because of increasing use of stents and ticlopidine to avoid stent-thrombosis ." ], "offsets": [ [ 0, 391 ] ] } ]	[ { "id": "ZfuerKardiologie.90880788.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 9, 16 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "time" ], "offsets": [ [ 37, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "standard" ], "offsets": [ [ 46, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038137" }, { "db_name": "UMLS", "db_id": "C0175675" } ] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "therapy" ], "offsets": [ [ 55, 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], "normalized": [ { "db_name": "UMLS", "db_id": "C0034036" } ] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "stenosis" ], "offsets": [ [ 289, 297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009814" } ] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 334, 337 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "stents" ], "offsets": [ [ 341, 347 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "ticlopidine" ], "offsets": [ [ 352, 363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040207" } ] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "stent-thrombosis" ], "offsets": [ [ 373, 389 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "stent-thrombosis" ], "offsets": [ [ 373, 389 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040053" } ] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "coronary stenosis" ], "offsets": [ [ 280, 297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242231" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880788.eng.abstr-s1-r1-t3.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerKardiologie.90880788.eng.abstr-s3-t3", "arg2_id": "ZfuerKardiologie.90880788.eng.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s1-r2-t3.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerKardiologie.90880788.eng.abstr-s3-t3", "arg2_id": "ZfuerKardiologie.90880788.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880788.eng.abstr-s1-r3-t3.2-t1.1", "type": "issue_in", "arg1_id": 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The purpose of this presentation is to investigate the determinants for decision making to use cardiac catheterization in patients after myocardial infarction ." ], "offsets": [ [ 0, 444 ] ] } ]	[ { "id": "ZfuerKardiologie.90880795.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Objectives" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "ZfuerKardiologie.90880795.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 26, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880795.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 57, 67 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880795.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "hospitals" ], "offsets": [ [ 84, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019994" } ] }, { "id": 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"ZfuerKardiologie.90880795.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "decision making" ], "offsets": [ [ 356, 371 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011109" } ] }, { "id": "ZfuerKardiologie.90880795.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "cardiac catheterization" ], "offsets": [ [ 379, 402 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018795" } ] }, { "id": "ZfuerKardiologie.90880795.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 421, 442 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880795.eng.abstr-s1-r1-t4.1-t7.1", "type": "carries_out", "arg1_id": "ZfuerKardiologie.90880795.eng.abstr-s3-t4", "arg2_id": "ZfuerKardiologie.90880795.eng.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerKardiologie.90880795.eng.abstr-s1-r2-t3.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerKardiologie.90880795.eng.abstr-s3-t3", "arg2_id": 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ZfuerKardiologie.90880815.eng.abstr	ZfuerKardiologie.90880815.eng.abstr	[ { "id": "ZfuerKardiologie.90880815.eng.abstr-passage-0", "type": "abstract", "text": [ "Antitachycardia pacing techniques ( ATP ) have proved useful for termination of ventricular tachycardia ( VT ) . However , little is known about the efficacy and safety off ATP during long-term follow-up in a larger study population . We analyzed the data of 80 ICD patients ( pts ) with spontaneous monormorphic VT , mean age 59 +/- 12 years , the mean follow-up was 26 +/- 17 months . 50 pts ( 62.5% ) had coronary artery disease , 18 ( 22.5% ) dilative cardiomyopathy ( DCM ) , the remaining 12 pts ( 15% ) had no or other cardiac diseases . 2926 episodes of ventricular tachycardia ( cycle length 349 +/- 51 ms , 240-520 ms ) occurred in 64/80 pts ( 80% ) , overall efficacy of ATP was 89.9% , acceleration occurred in 4.1% of VTs . Success of ATP did not correlate with positive ATP testing on induced arrhythmias , LVEF , NYHA class or aneurysm . Neither underlying heart disease nor antiarrhythmic medication had an impact on the ATP success rate . ATP efficacy was linked significantly to short VT cycle length ( VTCL , 240-300 ms , p 0.01 ) and long coupling intervals ( 91-97% ) , p 0.01 ) . Acceleration occurred in 32% of pts and in 4.1% of VT episodes ; it was also dependent on short VT cycle length ( 300 ms vs > 300 ms , p 0.04 ) and short coupling intervals ( 81% vs > = 81% , p = 0.01 ) ." ], "offsets": [ [ 0, 1306 ] ] } ]	[ { "id": "ZfuerKardiologie.90880815.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "pacing" ], "offsets": [ [ 16, 22 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0287990" }, { "db_name": "UMLS", "db_id": "C0520526" } ] }, { "id": "ZfuerKardiologie.90880815.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 23, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.90880815.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "ATP" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004482" }, { "db_name": "UMLS", "db_id": "C0001480" } ] }, { "id": "ZfuerKardiologie.90880815.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "tachycardia" ], "offsets": 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ZfuerKardiologie.90880823.eng.abstr	ZfuerKardiologie.90880823.eng.abstr	[ { "id": "ZfuerKardiologie.90880823.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the study was to compare the clinical outcome after AV node radiofrequency current ablation and pacemaker implantation in patients with permanent and paroxysmal atrial fibrillation . The study consecutively included 19 patients with permanent ( male n = 15 ; 55 +/- 13 years ) and 45 patients with paroxysmal atrial fibrillation ( male n = 31 ; 60 +/- 13 years ) . Clinical evaluation before and 1 year after ablation included the symptoms and the self-assessed state of health . Before ablation , both groups reported with a similar frequency about tachycardia ( permanent n = 15 ; paroxysmal n = 2 ) and palpitations ( permanent n = 5 ; paroxysmal n = 19 ) . Patients with permanent ( n = 7 ) atrial fibrillation had more often breathlessness than patients with paroxysmal atrial fibrillation ( n = 2 ) , whereas dizziness/syncope was more often reported by patients with paroxysmal ( n = 35 ) than with permanent arrhythmia ( n = 8 ) . Ablation improved symptoms in patients with permanent ( 89% ) as well as with paroxysmal atrial fibrillation ( 84% ) . The self-assessed state of health described as good had not patient before ablation and 63% patients with permanent and 47% with paroxysmal atrial fibrillation after ablation . There were no differences for the studied parameters between patients with permanent and paroxysmal atrial fibrillation ." ], "offsets": [ [ 0, 1367 ] ] } ]	[ { "id": "ZfuerKardiologie.90880823.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "aim" ], "offsets": [ [ 4, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0108800" } ] }, { "id": "ZfuerKardiologie.90880823.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "pacemaker" ], "offsets": [ [ 107, 116 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030163" } ] }, { "id": "ZfuerKardiologie.90880823.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "implantation" ], "offsets": [ [ 117, 129 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029976" } ] }, { "id": "ZfuerKardiologie.90880823.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 133, 141 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880823.eng.abstr-s1-t5", "type": "umlsterm", "text": [ 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ZfuerKardiologie.90880828.eng.abstr	ZfuerKardiologie.90880828.eng.abstr	[ { "id": "ZfuerKardiologie.90880828.eng.abstr-passage-0", "type": "abstract", "text": [ "While the cellular mechanisms of atherosclerosis have been intensively studied , the mechanisms leading to preferential localization of atherosclerotic lesions are less well understood . To further define these mechanisms , endothelial cells from coronary arteries , i.e. , vessels with frequent atheroscleritic lesions , were isolated and grown in vitro . In order to compare the reactions of both cell types , endothelial cells derived from microvessels of human hearts were isolated and cultured under identical conditions . Incubation of endothelial cells with oxidized LDL ( 75 µg/ml protein ) induced a significant increase in PAI-1 activity ( 182% , p 0.05 ) in coronary macrovascular endothelial cells . This stimulatory effect of ox-LDL was less significant in microvascular endothelial cells ( 144% , p 0.05 ) . n-LDL did not influence secreted PAI-1 activity . Stimulation with angiotensin II induced expression of E-selectin more effectively in coronary macrovascular than in microvascular endothelial cells . In addition , angiotensin II-induced E-selectin espression led to incresed E-selectin-dependent adhesion of HL60 cells to coronary macrovascular endothelial cells under flow conditions , while only little effect was observed with cardiac microvascular endothelial cells . In contrast , L-selectin-dependent adhesion , which has been shown to play an important role in inflammatory reactions , was preferentially observed in cardiac microvascular endothelial cells and could only be stimulated with TNF , not by angiotensin II . Therefore , these cellular differences may in part explain specific properties of cardiac endothelial cells : Such that atherosclerotic lesions are localized in macrovascular vessel segments , whereas inflammatory responses are predominantly found in the microvasculature ." ], "offsets": [ [ 0, 1823 ] ] } ]	[ { "id": "ZfuerKardiologie.90880828.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "atherosclerosis" ], "offsets": [ [ 33, 48 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004153" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 236, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "arteries" ], "offsets": [ [ 256, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "vessels" ], "offsets": [ [ 274, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005847" }, { "db_name": "UMLS", "db_id": "C0148346" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "in vitro" ], "offsets": [ [ 346, 354 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021135" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "cell" ], "offsets": [ [ 399, 403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 424, 429 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "human" ], "offsets": [ [ 459, 464 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "hearts" ], "offsets": [ [ 465, 471 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 554, 559 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "LDL" ], "offsets": [ [ 574, 577 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023823" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "protein" ], "offsets": [ [ 589, 596 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "PAI-1" ], "offsets": [ [ 633, 638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030190" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 704, 709 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "oxidized LDL" ], "offsets": [ [ 565, 577 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348035" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "ox-LDL" ], "offsets": [ [ 739, 745 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348035" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 796, 801 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "PAI-1" ], "offsets": [ [ 855, 860 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030190" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "angiotensin" ], "offsets": [ [ 889, 900 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003018" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "E-selectin" ], "offsets": [ [ 926, 936 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0115305" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 1014, 1019 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "angiotensin II" ], "offsets": [ [ 889, 903 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003009" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "angiotensin" ], "offsets": [ [ 1036, 1047 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003018" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "E-selectin" ], "offsets": [ [ 1059, 1069 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0115305" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s8-t3", "type": "umlsterm", "text": [ 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"normalized": [ { "db_name": "UMLS", "db_id": "C0001511" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s9-t3", "type": "umlsterm", "text": [ "role" ], "offsets": [ [ 1382, 1386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s9-t4", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 1480, 1485 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s9-t5", "type": "umlsterm", "text": [ "TNF" ], "offsets": [ [ 1520, 1523 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041368" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s9-t6", "type": "umlsterm", "text": [ "angiotensin" ], "offsets": [ [ 1533, 1544 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003018" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s9-t7", "type": "umlsterm", "text": [ "inflammatory reactions" ], "offsets": [ [ 1390, 1412 ] ], "normalized": [ { "db_name": 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ZfuerKardiologie.90880838.eng.abstr	ZfuerKardiologie.90880838.eng.abstr	[ { "id": "ZfuerKardiologie.90880838.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Clinical drawbacks of beta-blocker treatment in stable angina have motivated researchers to provide alternative heart rat lowering agents , such as tedisamil which additionally exerts antiischemic and antiarrhythmic effects by blockade of cellular repolarizing K+ currents ." ], "offsets": [ [ 0, 287 ] ] } ]	[ { "id": "ZfuerKardiologie.90880838.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "beta-blocker" ], "offsets": [ [ 35, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001645" } ] }, { "id": "ZfuerKardiologie.90880838.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 48, 57 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.90880838.eng.abstr-s1-t3", "type": "umlsterm", "text": [ 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ZfuerKardiologie.90880850.eng.abstr	ZfuerKardiologie.90880850.eng.abstr	[ { "id": "ZfuerKardiologie.90880850.eng.abstr-passage-0", "type": "abstract", "text": [ "We report about a 17 year old male patient with a cardiomyopathy secondary to type IV glycogenosis ( Andersens disease ) and class II immunoglobulin deficiency who underwent cardiac transplantation ." ], "offsets": [ [ 0, 199 ] ] } ]	[ { "id": "ZfuerKardiologie.90880850.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "old" ], "offsets": [ [ 26, 29 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0331059" } ] }, { "id": "ZfuerKardiologie.90880850.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "male" ], "offsets": [ [ 30, 34 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024554" }, { "db_name": "UMLS", "db_id": "C0086582" } ] }, { "id": "ZfuerKardiologie.90880850.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patient" ], "offsets": [ [ 35, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { 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ZfuerKardiologie.90880868.eng.abstr	ZfuerKardiologie.90880868.eng.abstr	[ { "id": "ZfuerKardiologie.90880868.eng.abstr-passage-0", "type": "abstract", "text": [ "Patients who have undergone coronary artery bypass grafting may develop acute myocardial infarction late after surgery . It is not exactly known in these patients whether acute infarction is predominantly caused by occlusion of bypass or native vessels . Also , there is no systematic and prospective data available with respect to an invasive , revascularizing therapeutic approach . Therefore , acute coronary angiograms were obtained in 21 consecutive patients with acute infarctions and remote bypass grafting to elucidate mechanisms causing myocardial infarction in these patients , and to assess results of catheter-based recanalization ." ], "offsets": [ [ 0, 644 ] ] } ]	[ { "id": "ZfuerKardiologie.90880868.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Patients" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880868.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 37, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880868.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "grafting" ], "offsets": [ [ 51, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040732" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerKardiologie.90880868.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "infarction" ], 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ZfuerKardiologie.90880885.eng.abstr	ZfuerKardiologie.90880885.eng.abstr	[ { "id": "ZfuerKardiologie.90880885.eng.abstr-passage-0", "type": "abstract", "text": [ "Several studies have demonstrated an association Chlamydia pneumoniae with coronary artery disease , suggesting that infection with C. pneumoniae increases the risk for coronary artery disease by factor 2 or more . Since atherosclerosis is considered to be a chronic inflammatory process , these data would fit into the response-to-injury hypothesis of atherosclerosis rather than representing a completely novel concept . Several pathomechanisms as increased cytokine synthesis , proliferative and proaggregatory effects could transmit the effects of chronic C. pneumoniae infection . Animal models and first clinical trials using antibiotic therapy seem to support an etiological role of C. pneumoniae in coronary artery disease . In this paper the current knowledge of the role of C- pneumoniae in coronary artery disease is reviewed and possible pathomechanisms are discussed ." ], "offsets": [ [ 0, 881 ] ] } ]	[ { "id": "ZfuerKardiologie.90880885.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "association" ], "offsets": [ [ 37, 48 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004083" } ] }, { "id": "ZfuerKardiologie.90880885.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "Chlamydia" ], "offsets": [ [ 49, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008148" }, { "db_name": "UMLS", "db_id": "C0008149" } ] }, { "id": "ZfuerKardiologie.90880885.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "pneumoniae" ], "offsets": [ [ 59, 69 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032285" } ] }, { "id": "ZfuerKardiologie.90880885.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 84, 90 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": 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ZfuerKardiologie.90880896.eng.abstr	ZfuerKardiologie.90880896.eng.abstr	[ { "id": "ZfuerKardiologie.90880896.eng.abstr-passage-0", "type": "abstract", "text": [ "Aims : An in vitro study of the flow convergence region in aortic regurgitation has shown that regurgitant flow rate can be derived from the local velocity v ( 7 mm ) at 7 mm distance above the leak orifice . This clinical study was performed to test this method in patients ." ], "offsets": [ [ 0, 276 ] ] } ]	[ { "id": "ZfuerKardiologie.90880896.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "distance" ], "offsets": [ [ 175, 183 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012751" } ] }, { "id": "ZfuerKardiologie.90880896.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "in vitro" ], "offsets": [ [ 10, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021135" } ] }, { "id": "ZfuerKardiologie.90880896.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "aortic regurgitation" ], "offsets": [ [ 59, 79 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003504" } ] }, { "id": "ZfuerKardiologie.90880896.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "method" ], "offsets": [ [ 256, 262 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.90880896.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 266, 274 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880896.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "clinical study" ], "offsets": [ [ 214, 228 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008972" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880896.eng.abstr-s2-r2-t1.2-t3.1", "type": "performs", "arg1_id": "ZfuerKardiologie.90880896.eng.abstr-s2-t1", "arg2_id": "ZfuerKardiologie.90880896.eng.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerKardiologie.90880896.eng.abstr-s2-r3-t3.1-t1.1", "type": "measures", "arg1_id": "ZfuerKardiologie.90880896.eng.abstr-s2-t3", "arg2_id": "ZfuerKardiologie.90880896.eng.abstr-s2-t1", "normalized": [] } ]
ZfuerKardiologie.90880906.eng.abstr	ZfuerKardiologie.90880906.eng.abstr	[ { "id": "ZfuerKardiologie.90880906.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : The Pura-Vario stent features 2 newly designed \" bridging segments \" for enhanced longitudinal flexibility , in order to allow easier and safer stent implantation ." ], "offsets": [ [ 0, 179 ] ] } ]	[ { "id": "ZfuerKardiologie.90880906.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "stent" ], "offsets": [ [ 30, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] }, { "id": "ZfuerKardiologie.90880906.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "flexibility" ], "offsets": [ [ 110, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242808" } ] }, { "id": "ZfuerKardiologie.90880906.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "stent" ], "offsets": [ [ 159, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038257" } ] }, { "id": "ZfuerKardiologie.90880906.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "implantation" ], "offsets": [ [ 165, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029976" } ] } ]	[]	[]	[]
ZfuerKardiologie.90880922.eng.abstr	ZfuerKardiologie.90880922.eng.abstr	[ { "id": "ZfuerKardiologie.90880922.eng.abstr-passage-0", "type": "abstract", "text": [ "Conventional echocardiographic methods of measuring left ventricular mass ( LVM ) are limited by assumptions of ventricular geometry and image plane positioning . Three-dimensional ( 3D ) echocardiography offers a promising new approach for more accurate determination of LVM . This study was performed to compare LVM measurement by one- ( 1D ) , two- ( 2D ) , and 3D echocardiography with magnetic resonance imaging ( MRI ) in patients ( pts ) with dilated cardiomyopathy ( DCM ) ." ], "offsets": [ [ 0, 482 ] ] } ]	[ { "id": "ZfuerKardiologie.90880922.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "methods" ], "offsets": [ [ 31, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "determination" ], "offsets": [ [ 255, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "measurement" ], "offsets": [ [ 318, 329 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242485" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "magnetic" ], "offsets": [ [ 390, 398 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024488" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "resonance" ], "offsets": [ [ 399, 408 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0459800" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "imaging" ], "offsets": [ [ 409, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011923" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "MRI" ], "offsets": [ [ 419, 422 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024485" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 428, 436 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t7", "type": "umlsterm", "text": [ "cardiomyopathy" ], "offsets": [ [ 458, 472 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027049" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t8", "type": "umlsterm", "text": [ "3D echocardiography" ], "offsets": [ [ 365, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0203378" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t9", "type": "umlsterm", "text": [ "magnetic resonance" ], "offsets": [ [ 390, 408 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0917874" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t10", "type": "umlsterm", "text": [ "dilated cardiomyopathy" ], "offsets": [ [ 450, 472 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007193" } ] }, { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-t11", "type": "umlsterm", "text": [ "magnetic resonance imaging" ], "offsets": [ [ 390, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024485" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90880922.eng.abstr-s3-r1-t9.1-t6.1", "type": "occurs_in", "arg1_id": "ZfuerKardiologie.90880922.eng.abstr-s3-t9", "arg2_id": 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ZfuerKardiologie.90880932.eng.abstr	ZfuerKardiologie.90880932.eng.abstr	[ { "id": "ZfuerKardiologie.90880932.eng.abstr-passage-0", "type": "abstract", "text": [ "With the increasing use of cross-sectional echocardiography in patients with overt or suspected pulmonary thromboembolism in the emergency rooms , more and more right atrial thrombi are detected . These are so-called \" transitthrombi \" from the venous system on their way to the pulmonary arteries and they are a severe presentation of thromboembolic disease . They appear as an imminent pulmonary embolism and usually coexists with an already massive embolism . In patients were a right atrial thrombus is associated with a patent foramen ovale , paradoxical arterial embolism has been observed . Right sided heart thrombi have a high mortality rate and need immediate treatment . In our hospital we have seen 14 patients with right atrial thrombi and pulmonary embolism in a period of 6 years . Three patients had cardiac arrest with a massive pulmonary embolism , seven patients presented with a submassive embolism . All patients were treated immediately after echocardiographic diagnosis without pulmonary angiography . In about half of the cases transesophageal echocardiography was done additionally for diagnosis and monitoring . Therapeutic options were thrombectomy , fibrinolysis or anticoagulants . We treated one of our patients with thrombectomy , eleven patients with fibrinolysis and two patients with anticoagulants ." ], "offsets": [ [ 0, 1334 ] ] } ]	[ { "id": "ZfuerKardiologie.90880932.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 20, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 63, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "thromboembolism" ], "offsets": [ [ 106, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040038" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "emergency" ], "offsets": [ [ 129, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013956" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "right" ], "offsets": [ [ 161, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035621" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "thrombi" ], "offsets": [ [ 174, 181 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087086" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "cross-sectional echocardiography" ], "offsets": [ [ 27, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013519" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "pulmonary thromboembolism" ], "offsets": [ [ 96, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0524702" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "arteries" ], "offsets": [ [ 289, 297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 351, 358 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "pulmonary arteries" ], "offsets": [ [ 279, 297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034052" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "embolism" ], "offsets": [ [ 398, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013922" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "embolism" ], "offsets": [ [ 452, 460 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013922" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "pulmonary embolism" ], "offsets": [ [ 388, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034065" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 466, 474 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "right" ], "offsets": [ [ 482, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035621" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "thrombus" ], "offsets": [ [ 495, 503 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087086" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "patent" ], "offsets": [ [ 525, 531 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030650" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "embolism" ], "offsets": [ [ 569, 577 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013922" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "foramen ovale" ], "offsets": [ [ 532, 545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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ZfuerKardiologie.90880941.eng.abstr	ZfuerKardiologie.90880941.eng.abstr	[ { "id": "ZfuerKardiologie.90880941.eng.abstr-passage-0", "type": "abstract", "text": [ "There is a significantly higher incidence of cerebral ischemia among patients with an atrial septal aneurysm and/or a patent foramen ovale . According to the information provided by modern diagnostic procedures - and in particular by transesophageal echocardiography - two pathogenic mechanisms should be considered as possible causes of the cerebral ischemia . Thrombi may develop locally in the left atrium or atrial septal aneurysm and lead to embolization or , alternatively , thrombi from the inflow region of the inferior vena cava may become trapped in the atrial septal aneurysm and pass through the patent foramen ovale to bring about embolization in the arterial bloodstream . Current treatment consists of life-long anticoagulation with cumarin derivatives in order to prevent further neurological complications . With this treatment , however , the risk of producing hemorrhages cannot be regarded as trivial , especially in old people ." ], "offsets": [ [ 0, 949 ] ] } ]	[ { "id": "ZfuerKardiologie.90880941.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "incidence" ], "offsets": [ [ 32, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220856" }, { "db_name": "UMLS", "db_id": "C0021149" } ] }, { "id": "ZfuerKardiologie.90880941.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "ischemia" ], "offsets": [ [ 54, 62 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022116" } ] }, { "id": "ZfuerKardiologie.90880941.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 69, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880941.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "aneurysm" ], "offsets": [ [ 100, 108 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002940" } ] }, { "id": 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Possible surgical procedures and there indications are discussed ." ], "offsets": [ [ 0, 727 ] ] } ]	[ { "id": "ZfuerKardiologie.90880948.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "man" ], "offsets": [ [ 26, 29 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" }, { "db_name": "UMLS", "db_id": "C0024554" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "history" ], "offsets": [ [ 37, 44 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019664" }, { "db_name": "UMLS", "db_id": "C0019665" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "posterior" ], "offsets": [ [ 56, 65 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032009" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 77, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 66, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 128, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 135, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "stenosis" ], "offsets": [ [ 163, 171 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009814" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 210, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 275, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "infarct-related" ], "offsets": [ [ 284, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "vessel" ], "offsets": [ [ 300, 306 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005847" }, { "db_name": "UMLS", "db_id": "C0148346" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "coronary artery disease" ], "offsets": [ [ 119, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010068" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "finding" ], "offsets": [ [ 328, 335 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243095" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "origin" ], "offsets": [ [ 351, 357 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079946" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "right" ], "offsets": [ [ 365, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035621" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 380, 386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 406, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s3-t6", "type": "umlsterm", "text": [ "pulmonary artery" ], "offsets": [ [ 396, 412 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034052" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "development" ], "offsets": [ [ 460, 471 ] ], "normalized": [ { 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ZfuerKardiologie.90880974.eng.abstr	ZfuerKardiologie.90880974.eng.abstr	[ { "id": "ZfuerKardiologie.90880974.eng.abstr-passage-0", "type": "abstract", "text": [ "Primary prevention of sudden cardiac death is hampered by the inability to accurately identify high risk patients . Various noninvasive methods such as determination of left ventricular function or heart rate variability as well as invasive electrophysiologic testing are currently used for risk stratification . Noninvasive measurement of microvolt T wave alternans ( TWA ) is a promising new method to assess repolarization abnormalities ; in experimental studies , TWA was associated with an increased incidence of ventricular tachyarrhythmias . Since the occurrence of TWA is heart rate-dependent , it is measured either during atrial pacing or during exercise stress testing . The first clinical validation of the method was performed in patients undergoing invasive EP testing to assess prediction of inducibility of ventricular tachyarrhythmias . A first prospective validation of the noninvasive method was performed in patients surviving out-of-hospital cardiac arrest fitted with an ICD . Further studies have shown a good concordance between invasive and noninvasive TWA determination . The occurrence of TWA in this population was of predictive value with respect to arrhythmia recurrence . Recently published data confirm the value of TWA assessment with respect to identification of patients with congestive heart failure at high risk of malignant ventricular tachyarrhythmias . The use of this method in post myocardial infarction risk stratification is currently under prospective evaluation ." ], "offsets": [ [ 0, 1509 ] ] } ]	[ { "id": "ZfuerKardiologie.90880974.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "prevention" ], "offsets": [ [ 8, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0687732" } ] }, { "id": "ZfuerKardiologie.90880974.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "death" ], "offsets": [ [ 37, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "ZfuerKardiologie.90880974.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 100, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "ZfuerKardiologie.90880974.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 105, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880974.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "Primary 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ZfuerKardiologie.90880982.eng.abstr	ZfuerKardiologie.90880982.eng.abstr	[ { "id": "ZfuerKardiologie.90880982.eng.abstr-passage-0", "type": "abstract", "text": [ "Hospital mortality from acute myocardial infarction has decreased in the last two decades . Left ventricular dysfunction therefore have been mainly due to ischemia . After extensive myocardial infarction , there are processes of adaptation ( remodeling ) which result in altered geometry of the left ventricle . The effects of this on neurohormonal systems ( organ regulation ) , on the changed ratio of myocyte mass and collagen content owing to reactive and reparative fibrosis ( organ texture ) and on the molecular and cellular mechanisms ( organ structure ) are of crucial importance . Depending on the structural changes , the myocardial contractility decreases . This associated with an activation of the circulating renin-angiotensin-aldosterone system ( RAAS ) ." ], "offsets": [ [ 0, 771 ] ] } ]	[ { "id": "ZfuerKardiologie.90880982.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Hospital" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019994" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 9, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 41, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Hospital mortality" ], "offsets": [ [ 0, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085556" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 30, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "dysfunction" ], "offsets": [ [ 109, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031847" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "ischemia" ], "offsets": [ [ 155, 163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022116" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "ventricular dysfunction" ], "offsets": [ [ 97, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242973" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "Left ventricular dysfunction" ], "offsets": [ [ 92, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242698" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 193, 203 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "adaptation" ], "offsets": [ [ 229, 239 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000934" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "ventricle" ], "offsets": [ [ 300, 309 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018827" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 182, 203 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "regulation" ], "offsets": [ [ 365, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034982" }, { "db_name": "UMLS", "db_id": "C0220905" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "collagen" ], "offsets": [ [ 421, 429 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009325" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "fibrosis" ], "offsets": [ [ 471, 479 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016059" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "the changed" ], "offsets": [ [ 383, 394 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025320" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "renin-angiotensin-aldosterone" ], "offsets": [ [ 724, 753 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035094" } ] }, { "id": "ZfuerKardiologie.90880982.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "renin-angiotensin-aldosterone" ], "offsets": [ [ 724, 753 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003018" } ] }, { "id": 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ZfuerKardiologie.90880991.eng.abstr	ZfuerKardiologie.90880991.eng.abstr	[ { "id": "ZfuerKardiologie.90880991.eng.abstr-passage-0", "type": "abstract", "text": [ "Cardiovascular diseases are the major cause of death not only in Germany . Coronary heart diseases result in substantial disability and loss of productivity and contribute to escalating costs of health care . Objective : It was out objective to estimate the costs of CHD for the German population from the perspective of the society . The characteristic of this approach is the calculating of costs until the approximated end of life . Methods : In the study , all health care costs concerning CHD in Germany were allocated to age , sex , health care sector and primary diagnosis on the basis of comprehensive data on morbidity , mortality , direct and indirect costs . For the estimate of indirect costs the human capital approach was taken . Considered as cases were all patients hospitalized in the reference year ( 1996 ) . The costs of this cohort in 1996 and up to their protected end of life were estimated . It was taken into account that , in comparison to the general population , life expectancy of cases with risk factors of CHD would have been reduced . In calculating indirect costs , gender and age specific unemployment rates were considered . All future costs were discounted by 4% from the reference year onward . Results : Direct costs are approximately 39 billion DM discounted at 4% , indirect costs total 73 billion DM . The average cost per case ( including morbiditiy and mortality ) until the approximated end of life is nearly 125,000 DM . Conclusion : In our cost analysis , the indirect costs are higher than the direct costs . For the future , it will be important to estimate the costs of prevalent cases until the end of life and to compare the influence of different interventions on these parameters and on the whole budget of the social security system ." ], "offsets": [ [ 0, 1788 ] ] } ]	[ { "id": "ZfuerKardiologie.90880991.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "diseases" ], "offsets": [ [ 15, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880991.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "cause" ], "offsets": [ [ 38, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "ZfuerKardiologie.90880991.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "death" ], "offsets": [ [ 47, 52 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "ZfuerKardiologie.90880991.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "Germany" ], "offsets": [ [ 65, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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ZfuerKardiologie.90881001.eng.abstr	ZfuerKardiologie.90881001.eng.abstr	[ { "id": "ZfuerKardiologie.90881001.eng.abstr-passage-0", "type": "abstract", "text": [ "One-hundred-thirty patients underwent 53 electrophysiological studies including programmed atrial and ventricular stimulation and 96 atrial overdrive stimulations on an outpatient basis . The indications for electrophysiological study were disabling palpitation , syncope , or presyncope , intracardiac conduction disturbance , and bradyarrhythmia . In one patient the efficacy of oral antiarrhythmic drug therapy was evaluated by repeat electrophysiological study . Atrial overdrive stimulation was performed in patients with atrial flutter or atrial tachycardia . On the basis of the result of electrophysiological testing , 25 patients were believed not to require any treatment , 16 patients received new drug therapy , 7 patients underwent catheter ablation in a second session , 2 patients had either a pacemaker or an ICD implanted , and 1 patient continued to receive the drug therapy that had been tested . Atrial overdrive stimulation resulted in a regular sinus rhythm in 66 patients ( 69% ) . Except for one patient in whom atrial flutter could not be terminated , atrial fibrillation was induced in the remaining 30 patients . After the procedure , patients were monitored for 30 min in case of overdrive stimulation , and for approximately 3 h after electrophysiological study or 6 h if additional coronary angiography had been performed . Severe complications were not observed . In 10 cases minor hematoma occurred at the puncture site without serious sequelae . - Outpatients electrophysiological study as well as atrial overdrive stimulation are feasible and safe in a selected group of patients ." ], "offsets": [ [ 0, 1615 ] ] } ]	[ { "id": "ZfuerKardiologie.90881001.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 19, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90881001.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "outpatient" ], "offsets": [ [ 169, 179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029921" } ] }, { "id": "ZfuerKardiologie.90881001.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "syncope" ], "offsets": [ [ 264, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039070" } ] }, { "id": "ZfuerKardiologie.90881001.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "presyncope" ], "offsets": [ [ 277, 287 ] ], "normalized": [ { "db_name": "UMLS", "db_id": 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In all previously published case reports ( n = 10 ) , a coronary dissection provided the entry door with subsequent retrograde progression of the dissection into the aortic root ." ], "offsets": [ [ 0, 329 ] ] } ]	[ { "id": "ZfuerKardiologie.90881023.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "dissection" ], "offsets": [ [ 14, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012737" } ] }, { "id": "ZfuerKardiologie.90881023.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "sinus" ], "offsets": [ [ 39, 44 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030471" } ] }, { "id": "ZfuerKardiologie.90881023.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "complication" ], "offsets": [ [ 68, 80 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.90881023.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "angioplasty" ], "offsets": [ [ 93, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162577" } ] }, { "id": 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Surgical decompression had to be performed urgently , because the pericardium could not be punctuated due to the position of the hydatid cyst ." ], "offsets": [ [ 0, 435 ] ] } ]	[ { "id": "ZfuerKardiologie.90881028.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "cyst" ], "offsets": [ [ 16, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010709" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "cause" ], "offsets": [ [ 44, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "cardiac tamponade" ], "offsets": [ [ 59, 76 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007177" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s2-t1", "type": 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"text": [ "dyspnea" ], "offsets": [ [ 214, 221 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013404" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s2-t7", "type": "umlsterm", "text": [ "pain" ], "offsets": [ [ 233, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s2-t8", "type": "umlsterm", "text": [ "dizziness" ], "offsets": [ [ 240, 249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012833" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s2-t9", "type": "umlsterm", "text": [ "period" ], "offsets": [ [ 264, 270 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025344" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s2-t10", "type": "umlsterm", "text": [ "unconsciousness" ], "offsets": [ [ 274, 289 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041657" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Surgical" ], "offsets": [ [ 292, 300 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "pericardium" ], "offsets": [ [ 358, 369 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031050" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "cyst" ], "offsets": [ [ 429, 433 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010709" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "Surgical decompression" ], "offsets": [ [ 292, 314 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376530" } ] }, { "id": "ZfuerKardiologie.90881028.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "hydatid cyst" ], "offsets": [ [ 421, 433 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013502" } ] } ]	[]	[]	[ { "id": "ZfuerKardiologie.90881028.eng.abstr-s1-r1-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerKardiologie.90881028.eng.abstr-s3-t2", 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ZfuerKardiologie.8087s145.eng.abstr

[ { "id": "ZfuerKardiologie.8087s145.eng.abstr-passage-0", "type": "abstract", "text": [ "Antithrombotic therapy is a basic part in the treatment of acute as well as chronic coronary syndromes . The rationale is an enhanced platelet activity with predomination of procoagulatory mechanisms in coronary artery disease . The current status of antiplatelet drugs , anticoagulation , and chronic thrombolysis used in the treatment of chronic coronary syndromes is discussed . It is concluded that low-dose aspirin is the current drug of choice for long term oral treatment in patients with stable chronic coronary artery disease . In contrast , oral anticoagulation with coumadin should be considered in patients with higher risk for atrial or ventricular thrombosis . The impact of long-term intermittent urokinase therapy in patients with end-stage coronary artery disease and refractory angina pectoris leads to a marked improvement of clinical symptoms . Oral blockade of platelet membrane glycoprotein IIb/IIIa receptor and clinical trials regarding antiischemic effects of low-molecular weight heparins in chronic coronary syndromes are expected for the future ." ], "offsets": [ [ 0, 1074 ] ] } ]

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[]

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ZfuerKardiologie.8087s157.eng.abstr

[ { "id": "ZfuerKardiologie.8087s157.eng.abstr-passage-0", "type": "abstract", "text": [ "Currently , catheter-based coronary therapy is performed using multiple interventional devices . Conventional balloon dilatation is still the dominating therapeutic modality with sufficient results in the majority of coronary lesions . Several alternative new devices were developed to improve acute results and long-term patency compared to balloon dilatation . With use of these devices ( stents , coronary atherectomy , laser angioplasty or high speed rotablator ) not every coronary lesion can be successfully treated , but several special indications for a differential indication of each of these systems have been found in randomized trials or clinical use . In this review , potential catheter-based strategies for a differential interventional treatment of patients with coronary artery disease are discussed ." ], "offsets": [ [ 0, 819 ] ] } ]

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[]

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ZfuerKardiologie.8087s166.eng.abstr

[ { "id": "ZfuerKardiologie.8087s166.eng.abstr-passage-0", "type": "abstract", "text": [ "Restenosis after percutaneous transluminal coronary angioplasty ( PTCA ) is a clinical problem associated with major ischemic events or repeat interventions in 20-50% of the treated patients . Systemic drug therapy has not yet been shown to prevent restenosis in clinical conditions . However , local therapeutic strategies are evolving , such as the catheter-based delivery of drugs , of antiproliferative genes , or of ionizing radiation . Experimental studies show that radiation therapy reduces restenosis rates , and preliminary clinical trials investigating a small number of patients indicate that , in particular , catheter-based radiation may be safe and effective . Randomized multicenter studies with long follow-up periods are needed to support these early results ." ], "offsets": [ [ 0, 778 ] ] } ]

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[]

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ZfuerKardiologie.8087s171.eng.abstr

[ { "id": "ZfuerKardiologie.8087s171.eng.abstr-passage-0", "type": "abstract", "text": [ "Treatment of symptomatic multivessel coronary disease with balloon angioplasty ( PTCA ) or bypass surgery as based on the results of 5 large , randomized trials is equivalent with respect to clinical outcome and risk . After PTCA , however , the rate of reinterventions is considerably higher . During long-term follow-up in the BARI trial , mortality was lower in diabetic patients undergoing surgery . Individual therapeutic decision making by the treating physician proved to be an important factor for the patients prognosis . The role of new devices ( stents ) is currently under investigation in new large randomized trials ." ], "offsets": [ [ 0, 631 ] ] } ]

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[]

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ZfuerKardiologie.8087s175.eng.abstr

[ { "id": "ZfuerKardiologie.8087s175.eng.abstr-passage-0", "type": "abstract", "text": [ "Minimally invasive direct coronary artery bypass surgery has evolved as a reliable method to perform left internal mammary artery ( LIMA ) bypass surgery to the LAD . This novel technique represents a synthesis of known approaches to coronary surgery using sternotomy without extracorporeal circulation and limited access techniques in general thoracic surgery . Applying specially designed tools for both harvesting the internal mammary artery and mechanically stabilizing the anterior surface of the heart during anastomosis , this approach is gaining widespread acceptance . A steadily growing number of patients with proximal LAD lesions are submitted to cardiac surgery and the procedure is performed with increasing success rates , now approaching 98% short term patency ." ], "offsets": [ [ 0, 778 ] ] } ]

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"db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.8087s175.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 146, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.8087s175.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "mammary artery" ], "offsets": [ [ 115, 129 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024661" } ] }, { "id": "ZfuerKardiologie.8087s175.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "coronary artery bypass" ], "offsets": [ [ 26, 48 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010055" } ] }, { "id": "ZfuerKardiologie.8087s175.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "internal mammary artery" ], "offsets": [ [ 106, 129 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0226276" } ] }, { "id": "ZfuerKardiologie.8087s175.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "technique" ], "offsets": [ [ 178, 187 ] ], 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[]

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ZfuerKardiologie.8087s188.eng.abstr

[ { "id": "ZfuerKardiologie.8087s188.eng.abstr-passage-0", "type": "abstract", "text": [ "Patients with refractory angina pectoris and end-stage coronary artery disease represent an increasing clinical problem . Numbers of these patients will increase in the future for improved survival due to effective secondary prevention of coronary artery disease . Next to the evaluation of clinical symptoms non-invasive objective parameters of myocardial ischemia are of major relevance before initiation of alternative treatment modalities and for verification of antiischemic effectiveness . Based on our own experience it can be shown that in these patients testing which is mainly based on the patients physical exercise capacity is only of limited value due to the early occurence of clinical symptoms . Furthermore diffuse perfusion abnormalities reduce the sensitivity of electrocardiographic and scintigraphic detection of ischemic changes . In contrast indirect measures of ischemia relating to the systolic or diastolic function of the left ventricle like dopplerechocardiography and radionuclide ventriculography seem to be promising approaches . This is confirmed by the results from the application of long-term intermittent urokinase therapy . Long-term intermittent urokinase therapy leads to an absolute enhancement of myocardial perfusion , which makes this approach superior to other medical interventions which are mainly based on a reduction of cardiac work-load ." ], "offsets": [ [ 0, 1386 ] ] } ]

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ZfuerKardiologie.8087s193.eng.abstr

[ { "id": "ZfuerKardiologie.8087s193.eng.abstr-passage-0", "type": "abstract", "text": [ "Pneumatic external counterpulsation operates by applying ECG-triggered diastolic pressure via cuffs to the vascular bed of the lower limbs . Comparable with intra-aortic balloon pumping , PECP produces a diastolic augmentation combined with increase of mean arterial pressure and coronary perfusion . American , Asian , and our own data demonstrated a reduction of angina pectoris through repeated use of PECP one or two hours daily for four to seven weeks . Exercise testing and thallium scanning confirmed the clinical improvement . PECP is a virtually riskfree treatment option in patients suffering from angina despite medical and interventionell treatment . Opening of collaterals and collateral growth induced by external counterpulsation are discussed as the cause of clinical benefit ." ], "offsets": [ [ 0, 793 ] ] } ]

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} ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "lower limbs" ], "offsets": [ [ 127, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "pressure" ], "offsets": [ [ 267, 275 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "perfusion" ], "offsets": [ [ 289, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031001" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "intra-aortic balloon pumping" ], "offsets": [ [ 157, 185 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021860" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Asian" ], "offsets": [ [ 312, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0078988" } ] }, { "id": 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"ZfuerKardiologie.8087s193.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "angina" ], "offsets": [ [ 608, 614 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002962" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 651, 660 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "growth" ], "offsets": [ [ 701, 707 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" }, { "db_name": "UMLS", "db_id": "C0220844" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "counterpulsation" ], "offsets": [ [ 728, 744 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010216" } ] }, { "id": "ZfuerKardiologie.8087s193.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "cause" ], "offsets": [ [ 766, 771 ] ], "normalized": [ { "db_name": 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[]

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ZfuerKardiologie.8087s199.eng.abstr

[ { "id": "ZfuerKardiologie.8087s199.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Does transmyocardial laser revascularization ( TMLR ) as a new surgical technique for treating patients with otherwise intractable angina pectoris improve myocardial perfusion or contractility ? Methods : Sixty-seven patients transferred for TMLR were evaluated by clinical evaluation , treadmill stress testing , echocardiography , ventriculography , and hybrid positron emission tomography preoperatively and in patients treated with TMLR at 6 and 12 month follow up . Hemodynamic assessment and clinical evaluation were performed perioperatively . Results : In 28/67 cases ( 42% ) CABG , in 9/67 patients ( 13% ) CABG in combination with TMLR ( combined group ) , and in 30/67 patients ( 45% ) only TMLR ( sole group ) were performed . Perioperative mortality in the sole group was 13% , in the combined group zero , and in the CABG group 11% . In all groups a significantly improved clinical status ( p =0 . 01 ) 1 week postoperatively and in TMLR groups also at 6 and 12 months was observed . In the TMLR groups treadmill tolerance ( p 0.05 ) improved , although function , perfusion and metabolism did not change significantly at the 6 and 12 month follow up . Conclusion : TMLR significantly improves clinical status and treadmill stress tolerance , but does not change function , perfusion , and metabolism ." ], "offsets": [ [ 0, 1329 ] ] } ]

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ZfuerKardiologie.8087s205.eng.abstr

[ { "id": "ZfuerKardiologie.8087s205.eng.abstr-passage-0", "type": "abstract", "text": [ "The high rate of coronary artery disease ( CAD ) mortality needs preventive intervention . Several studies have documented the effectiveness of LDL-cholesterol lowering in CAD primary prevention . The West of Scotland Prevention Study resulted in risk reduction by about one third through LDL-cholesterol lowering . The data indicate that specifically patients at high risk benefit from lipid reduction . High risk patients have besides high LDL-cholesterol one or more additional risk factors such as family history of premature coronary artery disease , hypertension , smoking , low HDL-cholesterol or diabetes . Therapy primarily aims at life style changes , secession of smoking and weight reduction as well as dietary changes to achieve LDL-cholesterol levels of 115-175 mg/dl ( 3-4 . 5 mmol/L ) , depending on the individual risk constellation . This strategy allows to reduce the number of patients needed to treat in order to prevent one CAD event ( 56 in isolated hypercholesterolemia ) to 14-24 in high risk persons , approaching the number ( n=13) known for effective lipid lowering in secondary prevention of coronary heart disease ." ], "offsets": [ [ 0, 1145 ] ] } ]

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[]

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ZfuerKardiologie.8087s225.eng.abstr

[ { "id": "ZfuerKardiologie.8087s225.eng.abstr-passage-0", "type": "abstract", "text": [ "Outpatient cardiac rehabilitation , as compared to inpatient rehabilitation , has substantial disadvantages for several patient groups . These drawbacks may lead to insufficient results in long term secondary prevention and to inadequate quality of life in patients with chronic heart disease . As outpatients , they remain in life circumstances which were , at least in part , causative for their heart diseases . Especially in elderly patients , those with a complicated course of disease , those who find adjusting their life style to the chronic disease state a daunting task , and those who find coping with the fact of being chronically ill as surpassing their psychological skills will find only in an inpatient setting all the relevant support delivered by a team of experts complementing each other for the benefit of the patient ." ], "offsets": [ [ 0, 840 ] ] } ]

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"ZfuerKardiologie.8087s225.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 483, 490 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.8087s225.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "life" ], "offsets": [ [ 524, 528 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "ZfuerKardiologie.8087s225.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 550, 557 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.8087s225.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "inpatient" ], "offsets": [ [ 709, 718 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021562" } ] }, { "id": "ZfuerKardiologie.8087s225.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "all" ], "offsets": [ [ 727, 730 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023449" } ] }, { "id": "ZfuerKardiologie.8087s225.eng.abstr-s4-t8", "type": 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[]

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ZfuerKardiologie.90880001.eng.abstr

[ { "id": "ZfuerKardiologie.90880001.eng.abstr-passage-0", "type": "abstract", "text": [ "Heart disease is the major cause of mortality in the developed world . Despite recent advances advances in the therapy of heart failure due to ACE inhibitors and beta-blockers , the prognosis of this syndrome is still poor . In the past few years , the effects of growth hormone ( GH ) and insulin-like growth factor-I ( IGF-I ) on heart morphology and function were extensively studied . Some studies dealing with experimental heart failure on animals and one controversial study dealing with the human heart failure suggest positive hemodynamic effects of GH and/or IGF-I treatment . This review summarizes the physiological effects of GH/IGF-I on the myocardium , their signal transduction mechanisms , and the data curently available on the therapeutic use of these agents ." ], "offsets": [ [ 0, 778 ] ] } ]

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"normalized": [ { "db_name": "UMLS", "db_id": "C0027061" } ] }, { "id": "ZfuerKardiologie.90880001.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 745, 756 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerKardiologie.90880001.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 757, 760 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerKardiologie.90880001.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "signal transduction" ], "offsets": [ [ 673, 692 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037083" } ] }, { "id": "ZfuerKardiologie.90880001.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "therapeutic use" ], "offsets": [ [ 745, 760 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039795" } ] } ]

[]

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ZfuerKardiologie.90880010.eng.abstr

[ { "id": "ZfuerKardiologie.90880010.eng.abstr-passage-0", "type": "abstract", "text": [ "Hypocalcemia is a relatively uncommon reversible cause of congestive heart failure . There are a few reports of hypocalcemic children who developed congestive heart failure associated with hypoparathyroidism . In all these patients , however , cardiac failure did not occur before the age of nine years . In addition , other striking noncardial manifestations of hypoparathyroidism , e.g. , convulsive seizures , had been present prior to cardiac symptoms ." ], "offsets": [ [ 0, 457 ] ] } ]

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[]

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ZfuerKardiologie.90880014.eng.abstr

[ { "id": "ZfuerKardiologie.90880014.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Prognostic data heart failure rely on epidemiological studies or large clinical trials . These data are not to transfer easily on everyday practice ." ], "offsets": [ [ 0, 162 ] ] } ]

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[]

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ZfuerKardiologie.90880023.eng.abstr

[ { "id": "ZfuerKardiologie.90880023.eng.abstr-passage-0", "type": "abstract", "text": [ "Todate internal mammary artery ( IMA ) is routinely used in coronary artery bypass grafting even in elder patients . However in patients with poor left ventricular function use of the IMA is discussed controversely in Germany . Main arguments against IMA are an increased operation time , initially lower blood flow , higher rates of reoperation for bleeding and more perioperative complications . In this study we investigated use of the IMA in patients with poor left vantricular function ( LVEF 40% ) compared to exclusively veingraft bypass surgery . 137 patients ( 105 m/32 f ) suffering from coronary artery disease with reduced LVEF ( 12-40% ) were randomized in the study . 67 patients received exclusively vein grafts ( group I ) , 70 patients routinely obtained an IMA graft . Criteria used for evalutation of IMA graft were operation time , postoperative bleeding , need for catecholamines , requirement of intensive care , perioperactive myocardial infarction and mortality . The number of distal anastomoses in each group was 3.1 ( 2-5 ) . The operation time varied in compliance with the number of distal anastomoses , but there were no significant differences between both groups . Postoperative bleeding until the secondpostoperative day was 905 ml in group II versus 569 ml in group I ; the difference was significant ( p 0.05 ) . The need of catecholamines after operation and hemodynamic parameters were comparable in both groups , there were no significant differences . Intensive care was required for a mean of 1.6 days in both groups , postoperative ventilation was 5.8 hours in group I versus 7.9 hours in group II , differences not significant . Ischemia or myocardial infarction could be demonstrated in 2 patients of group I ( 3% ) versus 4 patients of group II ( 5.7% ) . The differences between the groups were not significant . Cardiac low output syndromes without sights of myocardial infarction were apparent in 9 patients of group I ( 13.5% ) versus 2 patients of group II ( 2.9% ) , this difference being significant ( p 0.05 ) . Mortality after operation in both groups was higher than in patients with normal ventricular function , however the differences between the evaluated groups were not significant ( 5.9% in group I versus 4.3% in group II ) . Summarizing the above it can be concluded that patients with poor left ventricular function are at a higher riak when subjected to bypass operation ; the use of IMA did not show any disadvantages in comparison to exclusively veingraft surgery , except of a higher perioperative bleeding risk . Due to better long term results IMA should be used routinely also in bypass-patients with poor left ventricular function ." ], "offsets": [ [ 0, 2704 ] ] } ]

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[]

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ZfuerKardiologie.90880034.eng.abstr

[ { "id": "ZfuerKardiologie.90880034.eng.abstr-passage-0", "type": "abstract", "text": [ "Within the Cologne Model ( CM ) of outdoor cardiac rehabilitation ( OCR ) , phase II investigations about demand for this form of cardiac rehabilitation ( CR ) after acute cardiac diseases were carried out in three general hospitals , the cardiological and cardiosurgical university hospitals of Cologne . The subsequent questions were investigated : total number of coronary or cardiac operated patients , number of patients with indication for CR , and number of patients corresponding to the restricted indications of CM ( age below 65 , low risk patient , no cardiac operation ) . For these groups the acceptance or refusal of CR was checked . Subsequently a sample of patients corresponding to the criteria of CM or of operated patients were confronted with the additional offer of an OCR . The motivation for acceptance of rehabilitation in specialized hospitals ( ICR ) , OCR or refusal of each kind of CR was inquired ." ], "offsets": [ [ 0, 927 ] ] } ]

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[]

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ZfuerKardiologie.90880044.eng.abstr

[ { "id": "ZfuerKardiologie.90880044.eng.abstr-passage-0", "type": "abstract", "text": [ "This epidemiologic , retrospective follow-up mortality study is based on the data gathered in the department of forensic medicine at the University Hospital of Johann Wolfgang Goethe University in Frankfurt/Main . Over a period of 21 years ( 1972-1992 ) , roughly 21,000 forensic autopsies revealed 39 cases ( 0.19% ) of natural deaths occuring during sexual activity . Except for two women , all of these cases were men of an average age of 61.3 years . The most frequent cause of death was myocardial infarction ( n=21/53.8%), three of these cases involving pericardial tamponade accompanied by myomalacia . The medical history of twelve of the deceased showed a previous myocardial infarction . Most of the deaths took place during or after sexual intercourse or manual stimulation . In most cases sudden death occured during the sexual act with a prostitute . The annual incidence of sudden cardiovascular deaths during sexual activity is estimated to be 0.2/100,000 men . The risk for women is lower by a factor of 12." ], "offsets": [ [ 0, 1023 ] ] } ]

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"C0020028" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "period" ], "offsets": [ [ 221, 227 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025344" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "autopsies" ], "offsets": [ [ 280, 289 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004398" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "deaths" ], "offsets": [ [ 329, 335 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "women" ], "offsets": [ [ 385, 390 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "men" ], "offsets": [ [ 417, 420 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" }, { "db_name": "UMLS", "db_id": "C0024554" } ] }, 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"id": "ZfuerKardiologie.90880044.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "pericardial tamponade" ], "offsets": [ [ 560, 581 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007177" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "cause of death" ], "offsets": [ [ 473, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007465" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "history" ], "offsets": [ [ 622, 629 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019664" }, { "db_name": "UMLS", "db_id": "C0019665" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "infarction" ], "offsets": [ [ 685, 695 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021308" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "myocardial infarction" ], "offsets": [ [ 674, 695 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027051" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "deaths" ], "offsets": [ [ 710, 716 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "intercourse" ], "offsets": [ [ 751, 762 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009253" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "manual" ], "offsets": [ [ 766, 772 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024763" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s6-t4", "type": "umlsterm", "text": [ "sexual intercourse" ], "offsets": [ [ 744, 762 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009253" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s7-t1", "type": "umlsterm", "text": [ "death" ], "offsets": [ [ 808, 813 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s7-t2", "type": "umlsterm", "text": [ "sudden death" ], "offsets": [ [ 801, 813 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011071" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s7-t3", "type": "umlsterm", "text": [ "sexual act" ], "offsets": [ [ 833, 843 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009253" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "incidence" ], "offsets": [ [ 875, 884 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220856" }, { "db_name": "UMLS", "db_id": "C0021149" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "deaths" ], "offsets": [ [ 910, 916 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "ZfuerKardiologie.90880044.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "men" ], "offsets": [ [ 971, 974 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" }, { "db_name": 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[]

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ZfuerKardiologie.90880085.eng.abstr

[ { "id": "ZfuerKardiologie.90880085.eng.abstr-passage-0", "type": "abstract", "text": [ "In secondary prevention , statins are cost-effective and even more cost-effective than other lipid lowering drugs . Statins are especially favorable in patients with previous myocardial infarction compared to those with angina pectoris . For secondary prevention of coronary heart disease , statins should be administered generously . In primary prevention , statins are effective but not cost-efficient . Unfavorable results have to be expected especially in premenopausal women , younger patients , and in those with a low risk factor profile . For population based primary prevention , only dietary measures can be advocated ; however , apart from a serious lack of compliance their efficiency has not yet been proven . Preventive measures have their own prize ; in general they are considered not to prevent coronary heart disease but retard it . Therefore , such therapeutic interventions can be assumed not to reduce but rather to increase the \" direct \" medical costs . Furthermore , successful prevention of coronary heart disease leads , due to life-prolongation , to an increase in people out of work and in disabled patients due to age and/or disease . Therefore , an increase especially of the \" indirect \" costs for unemployment , pension , nursing homes , etc. must be expected ." ], "offsets": [ [ 0, 1293 ] ] } ]

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[]

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ZfuerKardiologie.90880097.eng.abstr

[ { "id": "ZfuerKardiologie.90880097.eng.abstr-passage-0", "type": "abstract", "text": [ "Atrial reentrant tachycardias ( ART ) are a potentially life-threatening complication in survivors of congenital heart disease surgery . From July 1993 to December 1997 , temporary transesophageal pacing was used to convert 29 tachycardia episodes in 19 patients . At the time of the first tachycardia episode , patients ' ages were 1 month to 26 years ( mean 9.8 yrs ) . Time from operation to onset of first tachycardia episode ranged from 1 day to 19 years . Onset was within the first 2 weeks postoperatively in 6 patients and occurred later in 13 patients ( 1 to 19 years after operation ) . Postoperative pacemaker implantation had been performed in 2 pts ; 17 of 19 pts were receiving antiarrhythmic medication . After placing a quadripolar transesophageal catheter , atrial and ventricular signals were recorded and atrial stimulation performed . Atrial cycle length of tachycardia ranged from 160-380 ms with 1:1 to 4:1 AV conduction . Temporary transesophageal pacing was performed following an algorithm starting with 4 extrastimuli ( 20 ms below atrial cycle length of tachycardia ) . Tachycardia terminated in 27 of 29 cases ( 93% ) without complications . In 3 cases , conversion was achieved by pacing after amiodarone 5 mg/kg i.v. After tachycardia conversion , sinus- or pacemaker rhythm was present in 20 cases . In 9 cases atrial fibrillation was recorded ; spontaneous conversion to sinus rhythm occurred after a maximum of 3 min ( 7 cases ) or persisted and required direct current cardioversion ( 2 cases ) . In conclusion , transesophageal atrial pacing is an effective , relatively noninvasive method for conversion of atrial reentrant tachycardias after operation for congenital heart disease ." ], "offsets": [ [ 0, 1719 ] ] } ]

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[]

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ZfuerKardiologie.90880103.eng.abstr

[ { "id": "ZfuerKardiologie.90880103.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of this prospective and randomized study was to evaluate the safety and efficacy of a reduced shock strength in transvenous implantable defibrillator therapy . So far clinical data concerning the safety margin of the shock energy in ICD therapy do not exist . The shock energy tested during long-term follow-up in this study was twice the intraoperatively measured defibrillation threshold ( DFT ) . A total number of 176 consecutive patients representing a typical cohort of ICD patients were evaluated . All patients received a non-thoracotomy lead system ( CPI , Endotak 0070 , 0090 ) and a biphasic cardioverter-defibrillator with the ability to store episodes ( Cardiac Pacemakers Inc. , Ventac TM PRx II , PRx III ) . The intraoperative defibrillation threshold ( DFT ) was evaluated in a step-down protocol ( 15 , 10 , 8 , 5 J ) and hat to be =15 J for inclusion into the study . The lowest effective energy terminating induced ventricular fibrillation had to be confirmed and was defined as DFT+ augmented defibrillation threshold . The DFT+ value was tested immediately after successful implantation , at discharge , and after a follow-up period of one year . Prior to implantation the patients were randomized into two groups . The energy of the first shock in the study group was programmed at twice DFT+ and in the control group at the maximum energy output ( 34 J ) . The efficacy of the first shock and its reproducibility in DFT testings and in spontaneous episodes during long-term follow-up of the study group were compared to those in the control group . A DFT+ value was found to be =15 J in 166 of 176 patients ( 94% ) . The DFT+ in the study group was 9.6+/-3.2; in control group 10.1+/-.35 J. The prohability of successful defibrillation at DFT+ level after one year was 84% . The success rate of the first shock meant to terminate induced ventricular fibrillation ( VF ) was 99.5% in the study group ( 217 of 218 episodes ) and 99% in the control group ( 201 of 203 episodes ) . During follow-up of 24+/-9 months spontaneous episodes in the study group , 83/86 ( 96.5 ) monomorphic ventricular tachycardias ( MVT ) and 38/40 ( 95% ) VF-episodes were converted successfully by the 2x DFT+ shock . In the control group the first shock was successful in 151/156 ( 96.8% ) spontaneous MVTs and in 30/33 ( 91% ) VF episodes . The efficacy of the first shock was not influenced by clinical data such as the underlying cardiac disease , left ventricular function , ongoing antiarrhythmic therapy with amiodarone , or the number of spontaneous episodes per day or by the DFT itself . At a mean follow-up of two years there was no significant difference between the two groups concerning the incidence of sudden cardiac death ( 2.4% in the study group vs. 3.8% in the control group ) . In conclusion programming the first shock with the ICD lead system used in this study at 2x DFT+ is as efficient as a shock energy of 34 J in order to terminate induced and spontaneous episodes of VT/VF . Thus , the safety of ICD-therapy is not impaired when programming the shock energy at the 2x DFT+ value ." ], "offsets": [ [ 0, 3118 ] ] } ]

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ZfuerKardiologie.90880113.eng.abstr

[ { "id": "ZfuerKardiologie.90880113.eng.abstr-passage-0", "type": "abstract", "text": [ "During a 4-week ambulatory cardiacc rehabilitation program , 262 patients with coronary artery disease ( CAD ) , 235 men and 27 women , 53.6+/-10.2 years , performed 30.5+/-2,9 exercise units . Before and after the rehabilitation program exercise , capacity was assessed by bicycle ergometry . There was a significant ( p 0.001 ) increase in the maximum exercise capacity at the end of the program ( 105.3+/-32.3 vs. 121.9+/-37.3 W ) . Physical work capacity on the 2.0 mmol lactate level improved ( p 0.001 ) from 72.2+/-23.5 to 86.4+/-25.8 W , on the 2.5 mmol/l level ( p 0.001 ) from 83.5+/-23.2 to 97.4+/-26.4 W , and on the 3.0 mmol/l level ( p 0.001 ) from 93.1+/-23.0 to 106.6+/-26.1 W. Despite enhanced performance , heart rate remained unaltered on the 2.0 , 2.5 , and 3.0 mmol/l lactate level . Furthermore , ergometric performance on predefined heart rate levels was significantly ( p 0.001 ) increased : 85/min: from 56.0+/-24.1 to 65.8+/-24.5 W ; 90/min: from 62.0+/-27.3 to 71.2+/-26 W ; 95/min: from 67.2+/-26.4 to 77.5+/-27.6 W ; 100/min: from 71.1+/-29.6 to 80.6+/-28.1 W ; 105/min: from 69.8+/-26.2 to 81.9+/-28.2 W and 110/min: from 73.6+/-28.9 to 90.4+/-29.4 W. The results demonstrate that physical performance in patients with CAD was improved by our novel ambulatory cardiac rehabilitation program . This improvement included an increase in maximum as well as endurance work capacity ; furthermore , this increase was accompanied by a decrease in resting and exercise heart rates . The results demonstrate an absolute increase of physical performance , more importantly an increase of physical performance at defined lactate levels in the presence of unchanged heart rates mediated by the rehabilitation program . Thus , this increase was independent of motivational factors in the patients and/or the investigators during the re-exercise test . On the contrary , our data demonstrate that it is based on an improvement of aerobic endurance capacity associated with a therapeutically beneficial significant decrease of heart rate for a defined workload . The effects were independent of pharmacological influences ( e.g. , -receptor antagonists ) . These findings are of clinical importance with respect to reduction of myocardial oxygen consumption in patients with CAD ." ], "offsets": [ [ 0, 2295 ] ] } ]

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ZfuerKardiologie.90880123.eng.abstr

[ { "id": "ZfuerKardiologie.90880123.eng.abstr-passage-0", "type": "abstract", "text": [ "Stent implantation serves as the gold standard for proximal lesions of the coronary arteries with a diameter between 2.75-3.5 mm . Our new concept aims at a reduced procedure duration and fluoro-time as well as a decreased ischemic period during stent implantation . A new therapeutic concept of a direct stent implantation without predilatation was tested using a specially developed balloon catheter on which various 14-16 mm long \" slotted-tube \" stents are mounted between two conical , radiopaque markers . In 105 consecutive patients , who were scheduled for angioplasty , this method of direct stent implantation was performed . Six of the procedures were performed for acute myocardial infarction and 8 in socalled high-risk procedures . The direct stent implantation was successful in 88% . In 6% , predilatation of the lesion site was necessary before stent placement . In the remaining 6% , a stent could not be successfully implanted despite the availability of various other systems . Comparison of the direct stent implantation with conventional stent placement with predilatation revealed that 1 ) The fluoro-time for direct stent implantation , compared to the conventional method , was 8.4+/-4.9 min vs. 13.7+/-8.0 min ; p 0.05 , respectively . Furthermore , there were less balloons used per lesion for direct stent implantation ( 1.4+/-0.4) compared to the conventional method ( 1.7+/-0.7), but there was not a significant difference . 2 ) If we compare those patients with successful direct stent implantation with those with the unsuccessful procedures , the latter group had a higher percent of angiographically visible calcification at the site of the lesion ( 80% vs. 18% ; p 0.01 ) . In addition , these patients had an increased average age ( 72+/-7 vs. 61+/-11 yrs ; p 0.01 ) . The success rate of direct stent implantation did not depend on lesion diameter stenosis before PTCA . Stent dislocation was observed in 3.8% of the procedures , and a single case of stent embolism was seen . In conclusion , the direct stent implantation offers the advantages of a shortened fluoro-time , the use of fewer balloons , and has the potential of less ischemic stress compared to the conventional method of stent implantation with predilatation , if old patients with calcified lesions are excluded . This should be proved on a large scale in future studies also considering a learning curve with regard to the new method . Whether this new approach also reduces the restenosis rate , warrants further studies ." ], "offsets": [ [ 0, 2528 ] ] } ]

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ZfuerKardiologie.90880133.eng.abstr

[ { "id": "ZfuerKardiologie.90880133.eng.abstr-passage-0", "type": "abstract", "text": [ "An increased pulmonary vascular resistance ( PVR ) or an increased transpulmonary gradient ( TPG ) is a risk factor for increased 3-day and 3-month mortality after heart transplantation ( HTx ) . The reversibility of increased PVR or TPG under pharmacologic testing is supposed to indicate a decreased probability of right ventricular failure/death after transplantation . We tested the response of an increased PVR ( > 2.5 Wood units , WU ) and/or of an increased TPG ( > 15 mm Hg ) in 29 right heart catheterizations ( thermodilution catheter ) of 23 patients ( 54+/-8 years , mean NYHA-class 3.1+/-0.6, ischemic n=8, dilated cardiomyopathy n=15). Increasing doses of prostaglandin I2 ( PGI2, mean maximum dose 13.5+/-6.4 ng/kg/min ) were applied stepwise over at least 10 min at the maximum dose level . We analzyed any dependence of the reversibility of PVR and TPG under prostaglandin I2 on hemodynamic values , echocardiographic parameters , demographic data , and laboratory findings . A decrease of PVR to a range usually accepted as no contraindication for HTx ( =4 WU ) was found in each patient without symptomatic systemic hypotension during application of PGI2 ( baseline value : 4.7+/-1.3 WU , during PGI2: 2.3+/-0.6 WU ) . An unresponsive , fixed increased PVR or TPG was not observed using PGI2. In 62% of investigations , both PVR and TPG decreased below 2.5 WU and 15 mm Hg , respectively . The extent of reversibility of PVR and TPG was individually different and did not depend on the mean pulmonary artery pressure , mean capillary wedge pressure , cardiac output , mean systemic artery pressure or echocardiographic parameters ( EDD , FS , ES-distance ) , sodium , urea or bilirubin levels , medication , age of the patients or the duration of the disease . The baseline PVR correlated inversely with its percentile value during PGI2 ( r=-0.76, p 0.05 ) . In advanced heart failure , PGI2 decreases PVR in ranges of lower risk concerning orthotopic HTx , without causing an intolerable systemic hypotension . The individual extent of reversibility of PVR and TPG under PGI2 is not influenced by basic hemodynamic parameters or the patient's demographic profile ." ], "offsets": [ [ 0, 2184 ] ] } ]

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[]

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ZfuerKardiologie.90880141.eng.abstr

[ { "id": "ZfuerKardiologie.90880141.eng.abstr-passage-0", "type": "abstract", "text": [ "Abstract Heparin induced thrombocytopenia type II ( HIT type II ) is the most serious complication of heparin treatment apart from bleeding , which is the most common side effect . Eleven days after coronary bypass grafting , a 71 year old patient showed a posterolateral myocardial infarction and a thrombocytopenia of 80,000/µl. This was considered a postoperative thrombocytopenia . Coronary angiography revealed closed venous bypass grafts . The right coronary artery ( RCA ) was revascularized by percutaneous transluminal coronary angioplasty ( PTCA ) and stent placement . During both coronary angiography and PTCA , heparin was administered to the patient . The platelet number did not change . Four days later the patient showed an inferior myocardial infarction and an AV-block III ° and a syncope . The following coronary angiography revealed RCA stent occlusion . HIT type II was presumed and recanalization was carried out using Lepirudin ( Refludan ) as the anticoagulant . After placing the guide wire , thrombi could be seen in the proximal RCA . Abciximab ( Reo pro ) , a monoclonal antibody against the glycoprotein IIb/IIIa receptor was additionally administered . Coronary angiography on the next day revealed only a small remaining thrombus . The AV-block disappeared immediately after revascularization . The diagnosis of HIT type II was confirmed through heparin-induced-platelet-activation-test ( Hipa-test ) and immunoassay ( PF 4/heparin-ELISA). This case report illustrates the complicated diagnosis of HIT type II and the successful simultaneous use of Lepirudin ( Refludan ) and Abciximab ( Reo pro ) . The number of platelets should be checked daily during heparin treatment . In the case of a thrombocytopenia , the treatment should be stopped immediately , and Hipa-test and PF 4/heparin-ELISA should be carried out ." ], "offsets": [ [ 0, 1849 ] ] } ]

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[]

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ZfuerKardiologie.90880163.eng.abstr

[ { "id": "ZfuerKardiologie.90880163.eng.abstr-passage-0", "type": "abstract", "text": [ "Hypertrophic cardiomyopathy ( HCM ) is a disease with different etiological , morphological , functional , clinical and therapeutic aspects . Recent investigations indicate that HCM is considerably widespread in the population ( 1:500 ) . The causes seem to generate from familial or sporadic abnormalities ( mutations ) . Depending on the clinical aspect , the complaints , and on the basis of morphologic and hemodynamic investigational results , we mainly have to consider two types of medical and surgical management ." ], "offsets": [ [ 0, 522 ] ] } ]

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[]

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ZfuerKardiologie.90880173.eng.abstr

[ { "id": "ZfuerKardiologie.90880173.eng.abstr-passage-0", "type": "abstract", "text": [ "Acute heart failure represents a severe complication of several cardiac disorders . Coronary artery disease , acute bacterial endocarditis or acute decompensation of preexisting heart valve disease as well as endstage cardiomyopathies are the most frequent underlying causes . Because of the high mortality , surgical therapy should be always considered in addition to medical treatment . However , any therapeutical intervention must be based on an immediate diagnosis to evaluate type and severity of the disease . Surgical options comprise coronary revascularization , valve replacement or -reconstruction as well as a temporary support by means of mechanical assist devices ." ], "offsets": [ [ 0, 679 ] ] } ]

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[]

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"normalized": [] } ]

ZfuerKardiologie.90880185.eng.abstr

[ { "id": "ZfuerKardiologie.90880185.eng.abstr-passage-0", "type": "abstract", "text": [ "The indication to treat symptomatic paroxysmal atrial fibrillation is discussed controversely . Successful medical treatment may result in the reduction of symptoms by improving hemodynamics in a reduction of thromboembolic events . However , several antiarrhythmic drugs are also known to increase the risk of proarrhythmic events ." ], "offsets": [ [ 0, 333 ] ] } ]

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[]

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ZfuerKardiologie.90880195.eng.abstr

[ { "id": "ZfuerKardiologie.90880195.eng.abstr-passage-0", "type": "abstract", "text": [ "Atrial fibrillation ( AF ) is the most frequent cardiac arrhythmia . However , despite manifold publications reflecting numerous clinical trials about treatment of AF , the management of this arrhythmia is still under controversial discussion , in daily clinical work as well as in research . The present study concentrates on three major questions : 1. How frequent are recurrences of AF in long-term follow-up ? Most of the previous studies used the occurrence of symptoms as a surrogate parameter for recurrences of AF , despite the expected high rate of asymptomatic relapses . In the present study a daily transtelephonic ECG transmission enables a rhythm monitoring independent of symptoms . 2. Is the frequency of AF recurrences significantly reduced by antiarrhythmic medication ? A direct comparison of class I and III antiarrhythmic drugs , which still are most frequently used for this indication , and of placebo will answer this question . 3. How safe is the long-term treatment for the prevention of AF recurrences with special respect to proarrhythmic effects ? The daily transtelephonic ECG transmission enables a quantitative and qualitative monitoring of tachy- and bradyarrhythmias independent of symptoms . Additionally , the daily analysis of ECG measures may detect parameters predicting subsequent life threatening arrhythmias ." ], "offsets": [ [ 0, 1351 ] ] } ]

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"offsets": [ [ 1184, 1200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079035" } ] }, { "id": "ZfuerKardiologie.90880195.eng.abstr-s9-t4", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 1216, 1224 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "ZfuerKardiologie.90880195.eng.abstr-s10-t1", "type": "umlsterm", "text": [ "analysis" ], "offsets": [ [ 1252, 1260 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerKardiologie.90880195.eng.abstr-s10-t2", "type": "umlsterm", "text": [ "ECG" ], "offsets": [ [ 1264, 1267 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013798" } ] }, { "id": "ZfuerKardiologie.90880195.eng.abstr-s10-t3", "type": "umlsterm", "text": [ "measures" ], "offsets": [ [ 1268, 1276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079809" } ] }, { "id": "ZfuerKardiologie.90880195.eng.abstr-s10-t4", "type": "umlsterm", "text": [ "life" ], "offsets": [ [ 1321, 1325 ] ], "normalized": 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ZfuerKardiologie.90880208.eng.abstr

[ { "id": "ZfuerKardiologie.90880208.eng.abstr-passage-0", "type": "abstract", "text": [ "In a prospectively designed randomized study , we compared the efficacy of sublingual nitroglycerine and intravenous enalaprilat in the out-of-hospital treatment of 46 hypertensive patients with pulmonary edema ( defined as rales over both lungs and systolic blood pressure > 200 mm Hg and diastolic blood pressure > 100 mg ) . The out-of-hospital treatment consists of oxygen ( 6 Ll/min ) via a face mask , furosemide 80 mg i.v. , opioids 10 mg s.c. , and either sublingual nitroglycerine ( n=23; initial dose : 0.8 mg ; repetitive application of 0.8 mg every 10 min until a cumulative dose of 3.2 mg ) or intravenous enalaprilat ( initial dose : 2.5 mg ; repetitive application of 2.5 mg every 30 min until a cumulative dose of 10 mg ) . The aim of the antihypertensive treatment was a reduction of systolic blood pressure below 160 mm Hg and diastolic blood pressure below 90 mm Hg until admission to the emergency department . In the emergency room , an arterial and venous blood sample was taken to determine the respiratory ( pO2, pCO2) and metabolic status ( pH value ; base-excess ; serum lactate ) of the patient . Successful antihypertensive treatment was observed in 13/23 ( 57% ) patients of the enalaprilat group and 15/23 ( 65% ) patients of the nitroglycerine group ( p=0.54). Systolic and diastolic blood pressure on admission were similiar in both treatment groups ( systolic RR : enalaprilat : 179 [ 31 ] mm Hg ; nitroglycerine : 184 [ 38 ] mm Hg ; p=0.59; diastolic RR : enalaprilat : 96 [ 14 ] mm Hg ; nitroglycerine : 101 [ 14 ] mm Hg ; p=0.12). No significant differences were observed between the enalaprilat and the nitroglycerine groups concerning respiratory and metabolic parameters on admission ( pO2: 67 [ 15 ] vs. 64 [ 17 ] mm Hg ; p=0.50; pCO2: 46 [ 9 ] vs. 47 [ 13 ] ; p=0.75; pH value : 7.27 [ 0.12 ] vs. 7.27 [ 0.09 ] ; p=0.98; BE : -4 . 2 [ 3.7 ] vs. -5 . 7 [ 4.1 ] ; p=0.23; lactate : 4.2 [ 3.3 ] vs. 4.2 [ 2.7 ] ; p=0.98). Intravenous enalaprilat did not exhibit any advantage compared to nitroglycerine in terms of blood pressure reduction or respiratory and metabolic parameters on admission to the emergency room . We conclude that enalaprilat is no substitute for nitroglycerine in the out-of-hospital treatment of hypertensive patients with pulmonary edema ." ], "offsets": [ [ 0, 2300 ] ] } ]

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[]

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ZfuerKardiologie.90880215.eng.abstr

[ { "id": "ZfuerKardiologie.90880215.eng.abstr-passage-0", "type": "abstract", "text": [ "Most people with the Metabolic Syndrome die from thrombotic complications superimposed to degenerative arterial vascular lesions , mostly myocardial infarction . Type-2-Diabetes is a risk factor per se for such complications , but often clusters with dyslipoproteinemia , hypertension and obesity . This is referred to as \" Metabolic Syndrome \" and often operates on a genetically programmed susceptibility which accelerates the pathogenesis of coronary artery disease in front of a much wider diabetes specific cardiopathy . From a pathophysiological point of view none of these associated risk factors explains the pathogenetic series of events leading to the precipitation of an occlusive thrombus at sites of complicated coronary plaques . In patients with the Metabolic Syndrome the coagulation system is switched towards a prethrombotic state , involving increased plasmatic coagulation , diminished fibrinolysis , decreased endothelial thromboresistance and predominantly platelet hyperreactivity ( \" diabetic thrombocytopathy \" ) . Some of these factors are associated with an increased coronary risk ( e.g. fibrinogen , PAI-1, platelets ) , but are also directly linked to the pathogenesis of \" atherothrombosis \" . Altered cardiac remodelling together with adhesion and coagulation mechanisms appears suitable to explain decreased functional performance of infarcted organs , decreased success of acute ( reduced fibrinolytic response , no reflow phenomenon ) and longterm intervention strategies for vessel patency ( PTCA , CABG ) in Diabetes . Glucose adjustment alone will not adequately neutralize these complex mechanisms , but in the situation of myocardial infarction eumetabolization with parenteral glucose-insulin-potassium infusion appears mandatory similar to non-diabetics . On the longterm a multidimensional interventional repertoire is required particularly in patients with the Metabolic Syndrome including antihypertensive , antidyslipoproteinemic and antithrombotic drugs , customized according to the individual patients needs as assessed by early diagnostic measures ( \" early secondary prevention \" ) ." ], "offsets": [ [ 0, 2134 ] ] } ]

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[]

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ZfuerKardiologie.90880225.eng.abstr

[ { "id": "ZfuerKardiologie.90880225.eng.abstr-passage-0", "type": "abstract", "text": [ "The case of a 57 year old patient is reported , who suffered from an acute myocardial infarction with maximum CK and CKMB values of 821 and 84 U/l , respectively . The patient underwent bicycle exercise testing 9 days after a myocardial infarction in 25 W steps every 2 min starting with 50 W. The ergometry was interrupted at 125 W because of ST segment depression of 0.28 mV in V6. Systolic blood pressure dropped to 55 mm Hg , combined with severe angina and shock . Volume substitution and catecholamines did not elevate blood pressure . Immediate M-mode and Doppler echo revealed a \" stiletto \" -shaped mitral regurgitation profile typical of acute mitral valve insufficiency . The transesophageal echocardiogram showed a distinct mass moving between the left ventricle and left atrium , diagnostic of papillary muscle rupture . Despite of shock , mitral valve replacement was performed successfully . To our knowledge , this is the first report of a papillary muscle rupture during exercise testing after myocardial infarction ." ], "offsets": [ [ 0, 1034 ] ] } ]

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[]

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ZfuerKardiologie.90880229.eng.abstr

[ { "id": "ZfuerKardiologie.90880229.eng.abstr-passage-0", "type": "abstract", "text": [ "A 61 year old diabetic patient with bacterial endocarditis probably caused by a congenital coronary fistula is presented . The fistula was already detected by transthoracic echocardiography . Transesophageal color-Doppler echocardiography identified the precise localization and course of the fistula . Additionally , in some parts of the fistula echogenic material could be seen that decreased in size after antibiotic treatment . Therefore , it was considered as corresponding to bacterial vegetations . Coronary angiography disclosed an ectopic aneurysmatic and elongated circumflex coronary artery . Thus , even in rare conditions such as coronary fistulas transesophageal echocardiography may be helpful to allow detection of morphological substrate of associated infective endocarditis ." ], "offsets": [ [ 0, 793 ] ] } ]

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[]

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ZfuerKardiologie.90880245.eng.abstr

[ { "id": "ZfuerKardiologie.90880245.eng.abstr-passage-0", "type": "abstract", "text": [ "Our knowledge on the molecular genetics of inherited cardiac arrhythmias is very recent in comparison to the advances of genetics achieved in other inherited cardiac disorders . This is related to the high mortality and early disease onset of these arrhythmias resulting in mostly small nucleus families . Thus , traditional genetic linkage studies that are based on the genetic information obtained from large multi-generation families were made difficult ." ], "offsets": [ [ 0, 458 ] ] } ]

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[]

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"arg2_id": "ZfuerKardiologie.90880245.eng.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerKardiologie.90880245.eng.abstr-s3-r1-t2.1-t5.1", "type": "uses", "arg1_id": "ZfuerKardiologie.90880245.eng.abstr-s3-t2", "arg2_id": "ZfuerKardiologie.90880245.eng.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerKardiologie.90880245.eng.abstr-s3-r2-t4.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerKardiologie.90880245.eng.abstr-s3-t4", "arg2_id": "ZfuerKardiologie.90880245.eng.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerKardiologie.90880245.eng.abstr-s3-r3-t1.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerKardiologie.90880245.eng.abstr-s3-t1", "arg2_id": "ZfuerKardiologie.90880245.eng.abstr-s3-t2", "normalized": [] } ]

ZfuerKardiologie.90880261.eng.abstr

[ { "id": "ZfuerKardiologie.90880261.eng.abstr-passage-0", "type": "abstract", "text": [ "Background and aim : Unstable angina , a common serious clinical entity , is associated with a high rate of complications . The aim of our study was to evaluate treatment costs of patients with uncomplicated and complicated follow-up in order to evaluate the economic consequences of new therapeutic strategies , like the introduction of GPIIb/IIIa blockers at our hospital ." ], "offsets": [ [ 0, 375 ] ] } ]

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[]

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ZfuerKardiologie.90880283.eng.abstr

[ { "id": "ZfuerKardiologie.90880283.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the study was the assessment of left ventricular ( LV ) systolic function and left ventricular mass following aortic valve replacement ( AVR ) due to aortic valve stenosis as well as the influence of regression of LV hypertrophy in patients with normal and impaired LV systolic function prior to surgery . 74 patients with severe aortic valve stenosis ( 29 female , 45 male , mean age 66 +/- 18 years ) were divided into 2 groups according to LV ejection fraction ( EF ) : Group 1 with EF > 50% ( n = 40 ) ; Group 2 with EF = 50% ( n = 34 ) . Furthermore , patients were differentiated into a group A without ( n = 53 ) and a group B with aortic regurgitation ( = II ° , n = 21 ) . All patients were examined by transthoracic echocardiography before and 1 month after surgery . There was a significant decrease of LV enddiastolic and endsystolic valume indices following AVR in group 2 and group B. Patients with preoperatively lower EF ( group 2 ) showed an increase in LV ejection fraction from 39 +/- 10% before AVR to 47 +/- 11% after AVR ( p 0.001 ) , whereas patients with preoperative normal EF ( group 1 ) showed a significant decrease in EF ( from 62 +/- 8% to 57 +/- 10% , p 0.05 ) . Also patients with combined aortic valve disease before AVR had an increase of EF after surgery ( from 45 %plusmn; 14% to 56 +/- 14% , p 0.03 ) . There were significant decreases of interventricular septum thickness and LV posterior wall thickness in group 1 and group A , whereas a significant decrease of LV anddiastolic diameter index was noted only in group B. Improvement of the NYHA functional class could be demonstrated in group 2 from 2.8 +/- 0.7 before to 2.2 +/- 0.6 after AVR , as well as in group B from 2.9 +/- 0.7 before to 1.9 +/- 0.7 after surgery . In conclusion , patients with impaired LV function or combined aortic valve disease showed a significant improvement of left ventricular systolic function after AVR , while patients with normal LV function presented a slight decrease of EF . There was a significant regression of left ventricular muscle mass in all groups independent of the left ventricular functional status ." ], "offsets": [ [ 0, 2150 ] ] } ]

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[]

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ZfuerKardiologie.90880290.eng.abstr

[ { "id": "ZfuerKardiologie.90880290.eng.abstr-passage-0", "type": "abstract", "text": [ "A case of atypical hypertrophic cardiomyopathy ( HCM ) with a calcified apical thrombus is presented . A 42 year old asymptomatic patient was admitted for evaluation of an abnormal electrocardiogram ( ECG ) which was recorded when the patient suffered from a bronchitis . The ECG showed giant negative T-waves in leads II , III , aVF , V3 to V6 associated with high QRS voltages in the precordial leads . The chest X-ray and fluoroscopy demonstrated a calcification in projection to the apical region of the heart . Echocardiography and the left ventricular ( LV ) cineangiography showed hypertrophy of the apical LV myocardium and an obliteration of the apical LV cavity . Magnetic resonance imaging identified a calcified thrombus in the apical cavity of the LV in the setting of an atypical HCM ." ], "offsets": [ [ 0, 799 ] ] } ]

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[]

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"arg2_id": "ZfuerKardiologie.90880290.eng.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880290.eng.abstr-s6-r11-t2.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerKardiologie.90880290.eng.abstr-s6-t2", "arg2_id": "ZfuerKardiologie.90880290.eng.abstr-s6-t1", "normalized": [] } ]

ZfuerKardiologie.90880296.eng.abstr

[ { "id": "ZfuerKardiologie.90880296.eng.abstr-passage-0", "type": "abstract", "text": [ "We report a case of LAD-stent deformation by extracorporeal cardiopulmonary resuscitation ( CPR ) shortly after stent implantation . To our knowledge , this is the first reported case ." ], "offsets": [ [ 0, 185 ] ] } ]

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[]

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ZfuerKardiologie.90880305.eng.abstr

[ { "id": "ZfuerKardiologie.90880305.eng.abstr-passage-0", "type": "abstract", "text": [ "The extent of physical activity and the dynamic performance capacity show an inverse relationship to cardiovascular mortality , independent of the influence of other risk factors , but the underlying mechanism remains uncertain . Most concepts assume that the aerobic capacity of the peripheral musculature is increased by training , and thus improved cardiocirculatory regulation and especially a more favorable stress reaction pattern are attained . This adaptation is essentially an inverse adaptation mechanism as in established cardiocirculatory insufficiency ." ], "offsets": [ [ 0, 566 ] ] } ]

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[]

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ZfuerKardiologie.90880315.eng.abstr

[ { "id": "ZfuerKardiologie.90880315.eng.abstr-passage-0", "type": "abstract", "text": [ "Thrombus formation at the site of atherosclerotic lesions , especially on a ruptured plaque , plays a central role in the \" atherothrombosis \" hypothesis . An activation of the hemostasis and a disturbed fibrinolysis are known . These alterations are especially marked in patients with acute coronary syndromes ." ], "offsets": [ [ 0, 312 ] ] } ]

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[]

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ZfuerKardiologie.90880324.eng.abstr

[ { "id": "ZfuerKardiologie.90880324.eng.abstr-passage-0", "type": "abstract", "text": [ "The importance of cell polarity as a fundamental biological principle is increasingly recognized in the cardiovascular system . Polar cell mechanisms underlie not only the development of the heart and blood vessels , but also play a major role in the adult organism for polarized endothelial functions such as the separation of the intra- and extravascular compartment and the vectorial exchange of substances between these compartments . Endothelial cells are connected through intercellular junctions which separate the functionally and structurally distinct luminal and abluminal cell surfaces . The luminal plasma membrane is in contact with the blood and takes part in the regulation of hemostasis . The abluminal cell membrane connects the endothelial cell with the basement membrane and modulates blood flow through the release of vasoactive substances . Results from epithelial model systems have shown that the polarized cell phenotype is generated by specific protein sorting and regulated protein trafficking between the trans-Golgi network and the cell surface . The polarized distribution of cell membrane proteins is maintained by anchorage with the cytoskeleton and limitation of lateral diffusion by tight junctions . Disturbances of cell polarity may contribute to the pathogenesis of disease states , including ischemic and radiocontrast-induced acute renal failure and carcinomas . Recent results have demonstrated the importance of cholesterol for protein traffic from the trans-Golgi network to the apical cell membrane . This novel intracellular function of cholesterol could point to a connection between cell polarity and the pathogenesis of arteriosclerosis . The polarity of the endothelium also has to be taken into account when developing gene-therapeutic strategies , since therapeutic success will not only depend on the efficient expression of the desired gene product , but also on its correct cellular location or secretion into the correct extracellular compartment . These examples demonstrate the biological and potentially clinical relevance of cell polarity in the cardiovascular system ." ], "offsets": [ [ 0, 2126 ] ] } ]

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[]

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ZfuerKardiologie.90880331.eng.abstr

[ { "id": "ZfuerKardiologie.90880331.eng.abstr-passage-0", "type": "abstract", "text": [ "The analysis of heart rate variability ( HRV ) and blood pressure variability ( BPV ) improves the characterization of patients with dilated cardiomyopathy ( DCM ) . In this study we tested the hypothesis that patients with DCM and controls show a different behavior in the baroreflex ( BR ) regulation ." ], "offsets": [ [ 0, 304 ] ] } ]

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[]

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ZfuerKardiologie.90880338.eng.abstr

[ { "id": "ZfuerKardiologie.90880338.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : The early determination of the myocardial manifestation is of considerable importance , since the prognosis of patients ( P ) with insulin dependent diabetes mellitus ( IDDM ) is generally masked by secondary cardiac complications . The aim of this study was to investigate whether young , asymptomatic P with IDDM and persisting normal systolic left ventricular ( LV ) function already show a diastolic LV dysfunction ." ], "offsets": [ [ 0, 435 ] ] } ]

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[]

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ZfuerKardiologie.90880363.eng.abstr

[ { "id": "ZfuerKardiologie.90880363.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : Homografts for valve replacement are indicated in acute valve endocarditis . It is assumed that they possess anti-infective properties . Homografts are an established indication in aortic valve replacement . We present our early results with homografts for mitral valve replacement in acute endocarditis ." ], "offsets": [ [ 0, 320 ] ] } ]

[ { "id": "ZfuerKardiologie.90880363.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Homografts" ], "offsets": [ [ 15, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040739" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "endocarditis" ], "offsets": [ [ 77, 89 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014118" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "Homografts" ], "offsets": [ [ 152, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040739" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "aortic valve" ], "offsets": [ [ 196, 208 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003501" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "homografts" ], "offsets": [ [ 257, 267 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040739" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "endocarditis" ], "offsets": [ [ 306, 318 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014118" } ] }, { "id": "ZfuerKardiologie.90880363.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "mitral valve" ], "offsets": [ [ 272, 284 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026264" } ] } ]

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ZfuerKardiologie.90880369.eng.abstr

[ { "id": "ZfuerKardiologie.90880369.eng.abstr-passage-0", "type": "abstract", "text": [ "Ventricular arrhythmias can both result from and cause myocardial dysfunction . We report a case of a two-year-old girl with ventricular tachycardia showing signs of heart failure consisting with a tachycardiomyopathy . The therapy with class I and class III antiarrhythmic drugs did not improve the cardiac situation significantly . The cardiologic investigations were consistent with the verapamilsensitive ventricular tachycardia in young adults . The treatment with verapamil led to a normal rhythm and function of the heart ." ], "offsets": [ [ 0, 530 ] ] } ]

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[]

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ZfuerKardiologie.90880374.eng.abstr

[ { "id": "ZfuerKardiologie.90880374.eng.abstr-passage-0", "type": "abstract", "text": [ "We report on a 65 year old man , in whom an ICD was implanted . Seven months later we found a remarkable close relation between the tip of the ICD electrode and the distal part of the left anterior descending artery ( LAD ) . LAD seems to be compressed from electrode during systole . This is possibly the cause of an ischemia in myocardial scintigraphy ." ], "offsets": [ [ 0, 355 ] ] } ]

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[]

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ZfuerKardiologie.90880394.eng.abstr

[ { "id": "ZfuerKardiologie.90880394.eng.abstr-passage-0", "type": "abstract", "text": [ "The leading pathophysiology of acute heart failure and cardiogenic shock is acute or subacute myocardial infarction . Reperfusion of the occluded coronary vessel accompanied by adequate support of cardiac function via assist systems , preferentially the intraaortic balloon counterpulsation , is the therapy of choice . Adjustment of preload ( high pulmonary capillary pressure in acute myocardial infarction with small heart , low pulmonary capillary wedge pressure in patients with large ventricles and chronic heart failure , high central venous pressure in patients with right heart failure , and right ventricle myocardial infarction ) and afterload ( peripheral arterial vasodilatation , recommended systolic arterial pressure 80-90 mm Hg ) but not maximization of cardiac output play an important role . Positive inotropic drugs should be considered when these strategies fail . In acute right heart failure in pulmonary hypertension , a preferential pulmonary vasodilatation with intravenous or inhalative prostaglandins or inhalative NO are of utmost importance . Systemic hypotension is not a contraindication in this pathophysiology ." ], "offsets": [ [ 0, 1145 ] ] } ]

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[]

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ZfuerKardiologie.90880400.eng.abstr

[ { "id": "ZfuerKardiologie.90880400.eng.abstr-passage-0", "type": "abstract", "text": [ "Prognosis of patients surviving acute myocardial infarction has substantially improved over the last two decades . However , stratification of patients at risk for death due to arrhythmic events remains a clinical challenge . Due to the important role of the autonomic nervous system in the genesis of sudden death , autonomic markers such as heart rate variability and baroreflex sensitivity have recently gained attention as risk stratification parameters . The present study reports the results of noninvasive risk stratification in 411 consecutive postinfarction patients treated due to contemporary therapeutical guidelines with a high proportion of patients discharged with a patent infarct related artery . The diagnostic arsenal of risk parameters comprised heart rate variability , baroreflex sensitivity , and more traditional markers such as non-sustained ventricular tachycardia , left ventricular ejection fraction , and ventricular late potentials . Patiens were followed for a mean of 33 +/- 21 months . Stepwise logistic regression analysis revealed that left ventricular function , both autonomic markers , and the patency of the infarct related artery were independent predictors of the prospectively defined primary study endpoint , i.e. , all-cause mortality plus ventricular tachyarrhythmic events . With respect to the secondary endpoint ( ventricular tachyarrhythmic events ) , left ventricular function , heart rate variability , and infarct vessel patency were independent predictors . Ventricular late potentials and nonsustained ventricular tachycardia had no predictive value with respect to ventricular tachyarrhythmic events . These findings from a large prospective long-term study demonstrate the value of markers of cardiac autonomic tone in identifying infarct survivors at risk for malignant ventricular tachyarrhythmias and sudden death ." ], "offsets": [ [ 0, 1874 ] ] } ]

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[]

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ZfuerKardiologie.90880410.eng.abstr

[ { "id": "ZfuerKardiologie.90880410.eng.abstr-passage-0", "type": "abstract", "text": [ "Myocardial infarction shows a circadian pattern with a maximum in the early morning hours . In patients with sleep-related breathing disorders ( SRBD ) , it is assumed that apnea-associated changes of hemodynamics , blood gases , and rheology lead to a higher frequency of myocardial infarction during sleep . This investigation analyzes the circadian pattern of myocardial infarction in patients with and without SRBD ." ], "offsets": [ [ 0, 420 ] ] } ]

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[]

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ZfuerKardiologie.90880418.eng.abstr

[ { "id": "ZfuerKardiologie.90880418.eng.abstr-passage-0", "type": "abstract", "text": [ "There have been some prospective randomized studies which compared primary angioplasty with intravenous thrombolysis in patients with an acute myocardial infarction ( AMI ) . However , a substantial number of patients with AMI who would not have been included in those trials are treated with one of these two therapeutic options . To describe the proportions , characteristics , and outcome of these patients treated with primary angioplasty or thrombolysis we analyzed the data of the prospective \" Maximal Individual Optimized Therapy for Acute Myocardial Infarction \" ( MITRA ) trial ." ], "offsets": [ [ 0, 589 ] ] } ]

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[]

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[] }, { "id": "ZfuerKardiologie.90880418.eng.abstr-s3-r13-t5.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerKardiologie.90880418.eng.abstr-s3-t5", "arg2_id": "ZfuerKardiologie.90880418.eng.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880418.eng.abstr-s3-r14-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerKardiologie.90880418.eng.abstr-s3-t2", "arg2_id": "ZfuerKardiologie.90880418.eng.abstr-s3-t1", "normalized": [] } ]

ZfuerKardiologie.90880426.eng.abstr

[ { "id": "ZfuerKardiologie.90880426.eng.abstr-passage-0", "type": "abstract", "text": [ "The discrimination of supraventricular versus ventricular tachycardias by an implantable cardioverter-defibrillator ( ICD ) is still a remaining clinical problem . The false positive detection of supraventricular as ventricular tachycardias causes inadequate electrical therapies of the ICD . To improve the increase of specificity criterias like \" Onset \" or \" Stability \" are offered . If these criterias during tachycardia are not fulfilled , the \" sustained rate duration \" ( SRD ) is offered as a security criterion . The SRD reasons the delivery of the therapy during tachycardia after a programmable time ." ], "offsets": [ [ 0, 613 ] ] } ]

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[]

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ZfuerKardiologie.90880434.eng.abstr

[ { "id": "ZfuerKardiologie.90880434.eng.abstr-passage-0", "type": "abstract", "text": [ "Supraventricular tachycardia ( SVT ) is a common complication early after cardiac surgery . A novel temporary atrial patch electrode ( TAPE ) for low energy atrial defibrillation was first implanted for intraoperative testing ans subsequently removed during open heart surgery in 10 patients ( Phase I ) . After the intraoperative testing period , the TAPE was implanted in 20 patients for postoperative termination of spontaneous episodes of supraventricular tachycardia ( SVT ) , biphasic shocks ( 1.2-5.0 J ) were applied , measuring the atrial defibrillation thresholds . Phase I : The mean intraoperative atrial defibrillation threshold was 1.6 +/- 1.4 J with a mena shock-impedance of 64.0 +/- 7.3 Ohms . Phase II : Postoperatively , 6 out of 20 patients ( 30 % ) developed 7 episodes of atrial fibrillation ( n=6) and atrial flutter ( n=1). In 5 patients , SVT could be converted to sinus rhythm ( n=5) or junctional rhythm ( n=1). The mean postoperative defibrillation threshold ( DFT ) was 2.7 +/- 2.1 J with a mean shock-impedance of 50.2 +/- 6.8 Ohms . In conclusion , the TAPE allows low-energy defibrillation of atrial fibrillation . It seems to be a useful alternative in the treatment of supraventricular tachycardia ." ], "offsets": [ [ 0, 1233 ] ] } ]

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[]

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ZfuerKardiologie.90880467.eng.abstr

[ { "id": "ZfuerKardiologie.90880467.eng.abstr-passage-0", "type": "abstract", "text": [ "The Brugada-Brugada syndrome is a rhythmologic disorder which can be diagnosed because of typical ECG criteria . A high-take off descending ST segment localized to the right chest leads , associated with right bundle branch block and ventricular fibrillation or syncopes are characteristic of the syndrome . ECG alterations in the right precordial leads were recorded in a 47 year old female patient who was admitted to hospital because of enteritis and associated syncope . The ECG alterations were initally not realized as Brugada-Brugada syndrome . Because of \" recognizing \" comparable ECG alterations during a congress lecture , the diagnosis was made . The patient was treated with an ICD ." ], "offsets": [ [ 0, 696 ] ] } ]

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[]

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ZfuerKardiologie.90880473.eng.abstr

[ { "id": "ZfuerKardiologie.90880473.eng.abstr-passage-0", "type": "abstract", "text": [ "25 patients with coronary heart disease ( CHD , 62 +/- 9 years ) and 18 subjects free from cardiovascular disease ( 28 +/- 9 years ) were tested on a cycle ergometer using a graded incremental test protocol : a ) in the common upright position , b ) as dynamic stress echocardiography in a semi-supine position . Whereas no relevant differences could be detected between the two conditions for the healthy subjects concerning heart rate , blood pressure , and rate-pressure product ( 2 x 3 ANOVA , t-test with -adjustment ) , the CHD patients showed both significantly higher heart rates as well as a significantly higher rate-pressure product ( 50 W : 15 300 +/- 2973 mmHg/min vs. 13 822 +/- 3042 mmHg/min ; 75 W : 18 028 +/- 3479 mmHg/min vs 16 337 +/- 2619 mmHg/min ) on equivalent stages during stress echocardiography if compared to the sitting position . There were no differences for systolic blood pressure in this group ; the diastolic values were higher in the sitting position at rest and during 50 W. Lactate concentrations ( determined only in the healthy subjects ) were significantly higher on all stages during dynamic stress echocardiography . The workload at the individual anaerobic threshold ( IAT ) was significantly lower ." ], "offsets": [ [ 0, 1245 ] ] } ]

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[]

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ZfuerKardiologie.90880481.eng.abstr

[ { "id": "ZfuerKardiologie.90880481.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Minimally invasive direct coronary artery bypass ( MIDCAB ) grafting without cardipulmonary bypass ( CPB ) through an anterolateral minithoracotomy has become a promising therapeutical option especially in multimorbid , elderly and reoperative patients with single vessel disease . However , this procedure precludes complete revascularization in multivessel disease because the minithoracotomy limits the surgical access either to anterior or lateral or posterior vessels of the beating heart . To expand the benefits of the MIDCAB concept to patients with multivessel disease , new interdisciplinary approaches have recently been introduced ." ], "offsets": [ [ 0, 657 ] ] } ]

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[]

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ZfuerKardiologie.90880489.eng.abstr

[ { "id": "ZfuerKardiologie.90880489.eng.abstr-passage-0", "type": "abstract", "text": [ "Although there are randomized data for CABG vs. medical therapy and CABG vs. PTCA in primary therapy of CAD , there is few evidence on the appropriate therapy of recurrent angina after prior CABG . We analyzed data from 1265 consecutive patients ( PTS . ) presenting for recurrent angina after previous CABG who required either re-CABG ( n=67), PTCA ( n=768) or medical therapy alone ( medRx ) ( n=430) at our institution during 1986 through 1996. Outcome after index therapy is monitored during 45 +/- 34 months . The 3 therapeutic groups were similar with respect to gender ( 84 % male ) , age at therapy ( 60 years ) , prevalence of diabetes ( 22 % ) , and time to first ischemic event after primary CABG ( 37 months ) . Actuarial survival was significantly higher in the PTCA-group at 1 , 5 and 10 years after therapy of recurrent angina , despite the freedom from subsequent re-intervention was significantly lower ( 1-year-survival 95 % [ 37 % ] vs. 95 % [ 3 ] medRx vs. 79 % [ 4 % ] re-CABG , 5-year-survival 87 % [ 57 % ] vs 78 % [ 17 % ] medRx vs. 50 % [ 4 % ] re-CABG and 10-year-survival 72 % [ 65 % ] vs. 63 % [ 31 % ] medRx vs. 50 % [ 15 % ] re-CABG resp. , p 0.0001 , [ numbers in brackets represent corresponding values for incidence of re-intervention , p 0.0001 ] ) . These findings were similar after adjustment for different baseline characteristics ." ], "offsets": [ [ 0, 1370 ] ] } ]

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[]

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ZfuerKardiologie.90880498.eng.abstr

[ { "id": "ZfuerKardiologie.90880498.eng.abstr-passage-0", "type": "abstract", "text": [ "Despite considerable progress in the knowledge about pathophysiology of cardiac allograft vascular disease ( CAVD ) , only few systematic studies are available , characterizing the natural course during long-term follow-up after heart transplantation ( HTX ) . Therefore , we analyzed in 354 heart transplant recipients ( 305 male , 45.9 +/- 11.2 years , mean observation period 5.8 +/- 3.0 years , range 0.9-12,4 years ) the results of 1129 coronary angiograms under the aspects of development , severity , localization , and progression of disease related to the prognosis of patients ." ], "offsets": [ [ 0, 588 ] ] } ]

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[]

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ZfuerKardiologie.90880507.eng.abstr

[ { "id": "ZfuerKardiologie.90880507.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of this serial 3 year follow-up study in 42 clinically stable patients with chronic aortic dissection was to assess quantitatively morphologic changes of the descending thoracic aorta ( AD ) using transesophageal echocardiography ( TEE ) . Communicating dissections ( ca ) were present in 16/19 patients with operated type I and in 11/23 patients with type III AD wherase 12/23 type III AD according to De Bakey were non-communicating ( nc ) . Diametral enlargement of the desc . thoracic aorta was 4 mm ( mean value ) at 1 year in all patients , 5.9 mm in type I ca , 7.2 mm in type III ca but only 3.1 mm in type III nc at 3 years . The ration between true lumen and false lumen ( FL ) changed in ca AD from 1:2 to 1:3 over the period of 3 years but remained constant at 1:1 in ncAD . Progressive thrombosis of the false lumen ( FL ) occurred in 76 % of patients but complete thrombosis of the FL occurred in only 6 % of type I ca , 18 % type III ca but in 84 % of type III nc patients ." ], "offsets": [ [ 0, 997 ] ] } ]

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[]

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ZfuerKardiologie.90880514.eng.abstr

[ { "id": "ZfuerKardiologie.90880514.eng.abstr-passage-0", "type": "abstract", "text": [ "Interventional duct occlusion is increasingly performed with detachable coils . In a series of 33 patients ( 34 procedures ) , we consistently used Gianturco-coils which were the initially employed coils . They are not securable but can be implanted in a simple manner . The rate of embolization was high ( 28 % ) in the first 14 procedures ; however , it declined to 5 % in the last 20 patients . We modified the technique by partially blocking the duct , when necessary , with a catheter which was advanced from the pulmonary artery and by implanting up to three coils . There was only one embolization and one small residual shunt in the last 20 patients . The mean fluoroscopy time in these patients was 11.0 +/- 5.8 minutes and decreased to 7.0 +/- 3.2 minutes in the last 10 patients with successful closure . Considering our experience , we continue to recommend the use of Gianturco-coils especially in the small duct which can be closed quickliy at low cost ." ], "offsets": [ [ 0, 968 ] ] } ]

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[]

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ZfuerKardiologie.90880521.eng.abstr

[ { "id": "ZfuerKardiologie.90880521.eng.abstr-passage-0", "type": "abstract", "text": [ "A 70-year-old woman with severely symptomatic hypertrophic obstructive cardiomyopathy was unresponsive to drug treatment . She had recurrent ventricular tachyarrhythmias and syncope and was at high risk for sudden death ; a dual chamber pacemaker defibrillator ( DDD-ICS ) was implanted . Her initial left ventricular outflow tract gradient was 80 mmHg and fell to 40 mmHg during dual-chamber pacing at an atrial ventricular delay of 140 ms . In the follow-up over six months she was asymptomatic with respect to angina pectoris ; ventricular tachycardias could be successfully terminated by antitachycardia pacing or by shocks . A dual chamber pacemaker defibrillator is an important therapeutic option for patients with symptomatic hypertrophic obstructive cardiomyopathy and ventricular tachyarrhythmias ." ], "offsets": [ [ 0, 808 ] ] } ]

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"id": "ZfuerKardiologie.90880521.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "obstructive cardiomyopathy" ], "offsets": [ [ 59, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007194" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "hypertrophic obstructive cardiomyopathy" ], "offsets": [ [ 46, 85 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007194" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "tachyarrhythmias" ], "offsets": [ [ 153, 169 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0080203" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "syncope" ], "offsets": [ [ 174, 181 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039070" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "risk" ], "offsets": [ [ 198, 202 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "death" ], "offsets": [ [ 214, 219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011065" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "pacemaker" ], "offsets": [ [ 237, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030163" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "sudden death" ], "offsets": [ [ 207, 219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011071" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "pacing" ], "offsets": [ [ 393, 399 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0287990" }, { "db_name": "UMLS", "db_id": "C0520526" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "angina" ], "offsets": [ [ 513, 519 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002962" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "tachycardias" ], "offsets": [ [ 543, 555 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039231" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "pacing" ], "offsets": [ [ 608, 614 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0287990" }, { "db_name": "UMLS", "db_id": "C0520526" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "shocks" ], "offsets": [ [ 621, 627 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036974" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "angina pectoris" ], "offsets": [ [ 513, 528 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002962" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "ventricular tachycardias" ], "offsets": [ [ 531, 555 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042514" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "pacemaker" ], "offsets": [ [ 645, 654 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030163" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "therapeutic" ], "offsets": [ [ 685, 696 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 708, 716 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "hypertrophic" ], "offsets": [ [ 734, 746 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020564" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "cardiomyopathy" ], "offsets": [ [ 759, 773 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027049" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "tachyarrhythmias" ], "offsets": [ [ 790, 806 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0080203" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s5-t7", "type": "umlsterm", "text": [ "obstructive cardiomyopathy" ], "offsets": [ [ 747, 773 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007194" } ] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s5-t8", "type": "umlsterm", "text": [ "hypertrophic obstructive cardiomyopathy" ], "offsets": [ [ 734, 773 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007194" } ] } ]

[]

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"ZfuerKardiologie.90880521.eng.abstr-s5-t2", "arg2_id": "ZfuerKardiologie.90880521.eng.abstr-s5-t8", "normalized": [] }, { "id": "ZfuerKardiologie.90880521.eng.abstr-s5-r52-t6.1-t8.1", "type": "degree_of", "arg1_id": "ZfuerKardiologie.90880521.eng.abstr-s5-t6", "arg2_id": "ZfuerKardiologie.90880521.eng.abstr-s5-t8", "normalized": [] } ]

ZfuerKardiologie.90880529.eng.abstr

[ { "id": "ZfuerKardiologie.90880529.eng.abstr-passage-0", "type": "abstract", "text": [ "We report on a patient in whom a restenosis after two PTCA procedures was treated with directional coronary atherectomy . In the second DCA maneuvre a spiral dissection , type D , developed from ostium to restenosis with a balloon shaped part in the wall of the aorta ascendens . This part disappeared nearly completely by next day . The dissection in the right coronary artery persisted three months later until a bypass operation and was not visible after two years ." ], "offsets": [ [ 0, 469 ] ] } ]

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[]

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ZfuerKardiologie.90880550.eng.abstr

[ { "id": "ZfuerKardiologie.90880550.eng.abstr-passage-0", "type": "abstract", "text": [ "Arrhythmogenic right ventricular cardiomyopathy ( ARVC ) is a heart muscle disease of unknown cause . It can cause both cardiac arrrhythmia and heart failure or sudden death . As such patients typically will present to one of three groups depending upon the symptoms at presentation : the pathologist , the physician or the arrhythmologist . Typically a young patient who presents with presyncope or syncope may be investigated by an electrophysiologist and have ventricular tachyarrhythmias . Sadly some young individuals with ARVC may present to a pathologist with sudden cardiac death . Those that survive repeated bouts off arrhythmia and/or some individuals with primary heart failure may initially present to general physicians/cardiologists ." ], "offsets": [ [ 0, 749 ] ] } ]

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[]

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ZfuerKardiologie.90880555.eng.abstr

[ { "id": "ZfuerKardiologie.90880555.eng.abstr-passage-0", "type": "abstract", "text": [ "Diagnosis of systemic venous drainage is mandatory for patients with congenital heart disease planned for cavopulmonary anastomosis or any Fontan-type palliation . Preexisting venous channels as the persistent left superior vena cava are common in cardiac anomalies and may lead to postoperative deterioration and cyanosis . We describe a 6 month old boy with a complex imbalanced atrioventricular septal defect who developed cyanosis in the very early postoperative period , following bidirectional cavopulmonary anastomosis . It was caused by ineffective lung perfusion due to a reopened persistent left superior vena cava with drainage to the coronay sinus ." ], "offsets": [ [ 0, 661 ] ] } ]

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[]

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ZfuerKardiologie.90880559.eng.abstr

[ { "id": "ZfuerKardiologie.90880559.eng.abstr-passage-0", "type": "abstract", "text": [ "From February 1991 to May 1998 , 340 patients had a cardioverter/defibrillator ( ICD ) implanted . Mean age was 64 +/- 9 years , 278 male and 62 female . 60% of patients had coronary artery disease and 31% dilative cardiomyopathy . Ejection fraction was 38 +/- 14% . The indication for an implantable cardioverter/defibrillator was in 57% of patients ventricular tachycardia , in 43% ventricular fibrillation . 298 patients had a single-chamber cardioverter/defibrillator implanted , 42 patients a dual-chamber cardioverter/defibrillator . In 25 patients additional subcutaneous patch or array electrodes and in 2 patients additional epicardial patch electrodes were implanted . Implantation site was in 92 patients abdominal and in 248 pectoral . Over a period of 7 years 34 lead-related complications occured in 33 patients ( 9.7% ) , after a median of 2 months after implantation . Diagnosis was made by routine chest x-ray in about 55% of lead-related complications , by clinical presentation ( inadequate therapy , pain ) in 24% , and by electrical parameters in 21% . In patients with an abdominal implantation site , lead-related complications occurred in 20% , in contrast to 6% in patients with a pectoral implantation site . Regarding patients with pectoral implantation site , lead-related complications were observed in 12% of patients with a dual-chamber ICD vs 4% with a single-chamber ICD ( p = 0.05 ) , due to dislocation of atrial electrodes with dual-chamber ICD . There were no differences in clinical parameters between patients with pectoral vs abdominal and between single vs dual-chamber ICD ." ], "offsets": [ [ 0, 1616 ] ] } ]

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[]

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ZfuerKardiologie.90880566.eng.abstr

[ { "id": "ZfuerKardiologie.90880566.eng.abstr-passage-0", "type": "abstract", "text": [ "A high specificy and a high positive prediction has been reached in risk stratification for a sudden cardiac death after acute myocardial infarction ( AMI ) by combining multiple methods . But sensitivity and negative prediction are still not satisfying . There are the same physiological processes underlying magnetcardiography ( MCG ) and electrocardiography ( ECG ) . Nevertheless , the signals in each method contain different information ." ], "offsets": [ [ 0, 444 ] ] } ]

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[]

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ZfuerKardiologie.90880574.eng.abstr

[ { "id": "ZfuerKardiologie.90880574.eng.abstr-passage-0", "type": "abstract", "text": [ "Due to the limited efficacy of drug therapy in atrial fibrillation and the high rate of recurrence , strong efforts were made to find non-pharmacological strategies . For three years now , the implantable atrial defibrillator Metrix from InControl has been available as an alternative therapy . From October 1995 to the present the atrial defibrillator was implanted in 179 patients worldwide . The sensitivity of the system and its algorithms to detect atrial fibrillation is 90% ; the specifity to detect sinus rhythm is 100% . In 121 of 179 patients , 748 episodes of spontaneous atrial fibrillation were treated with 2.4 shocks per episode . No proarrhythmic event or stroke was seen . A cardioversion to sinus rhythm could be achieved in 95% of patients ; the overall clinical success rate was 88% . In 7% of all patients , early recurrence of atrial fibrillation ( ERAF ) occurred that could not be converted into stable sinus rhythm after further cardioversions and antiarrhythmic therapy . In 4.1% there were lead-related complications , in 4 patients the device had to be explanted because of ineffective therapy , and in 3 patients the device had to be changed because of loss of telemetry or early depletion of battery . In 8 patients , postoperative complications were seen ( infections , pneumothorax and thrombosis of the subclavian vein ) . Overall , the implantable atrial defibrillator Metrix is an effective and safe alternative in treating atrial fibrillation ." ], "offsets": [ [ 0, 1480 ] ] } ]

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[]

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ZfuerKardiologie.90880582.eng.abstr

[ { "id": "ZfuerKardiologie.90880582.eng.abstr-passage-0", "type": "abstract", "text": [ "In a prospective , randomized study of patients with acute manifestation of coronary heart disease and hypercholesterolemia ( LDL cholesterol > =130 =250mg/dl), we compared the effect of an early-initiated , intensified therapy to usual care antilipidemic therapy with respect to coronary lesions and clinical events . Patients were included immediately following acute myocardial infarction and/or PTCA because of severe/instable angina pectoris . The intensified therapy consisted of pravastatin 20-40mg with addition of colestyramine and/or nicotinic acid , if necessary , to achieve an LDL cholesterol =130mg/dl. In the control group , antilipidemic therapy was left up to the private physician ." ], "offsets": [ [ 0, 700 ] ] } ]

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[]

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ZfuerKardiologie.90880591.eng.abstr

[ { "id": "ZfuerKardiologie.90880591.eng.abstr-passage-0", "type": "abstract", "text": [ "Endothelin has both vasoconstrictor and mitogenic properties and might , therefore , play a role in the pathogenesis of acute coronary syndromes and coronary atherosclerosis . The aim of the study was to characterize the mechanisms and kinetics of cardiac endothelin-1 ( ET-1) release following a local endothelial injury during PTCA ( group A ) and after sustained myocardial ischemia ( group B ) . Additionally , the precision of agreement between measurements in coronary sinus and peripheral venous samples should be analyzed ." ], "offsets": [ [ 0, 531 ] ] } ]

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[]

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ZfuerKardiologie.90880622.eng.abstr

[ { "id": "ZfuerKardiologie.90880622.eng.abstr-passage-0", "type": "abstract", "text": [ "The analysis of wall motion abnormalities with dobutamine stress echocardiography is an established method for the detection of myocardial ischemia . With ultrafast magnetic resonance tomography , the application of identical stress protocols as used for echocardiography is possible ." ], "offsets": [ [ 0, 285 ] ] } ]

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[]

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ZfuerKardiologie.90880631.eng.abstr

[ { "id": "ZfuerKardiologie.90880631.eng.abstr-passage-0", "type": "abstract", "text": [ "Aims : The flow convergence method enables the determination of flow across restrictive orifices . It was validated for planar orifice plates and atrioventricular valves . However , its quantitative application to aortic regurgitation is complicated due to the complex valve anatomy which distorts the converging flow field . An open angle formed by the leaflets causes relatively lower velocities in the region near the orifice , resulting in underestimation of flow . Confinement of the flow convergence region by the ascending aorta relatively increases the velocities at greater distance to the orifice and can cause overestimation of flow . We hypothesized that there is a region at intermediate distance to the orifice , where both these effects on the flow field are minimal , so that the local velocity there is only a function of flow . Methods and results : In a flow model , aortic regurgitation was simulated . The flow convergence was imaged by color Doppler . Different scanning directions were used ( analogue to apical and parasternal approach ) . Velocity profiles across the flow convergence were read along the line from the scanhead to the orifice . At a distance of 7 mm to the orifice , a uniform value was found for the ratio of local velocity v ( 7 mm ) /flow ( =0 . 28cm-2). Variations in size ( 3.5 to 7 mm ) , site ( central versus lateral ) and leaflet angle ( planar versus inverted funnel ) of the orifice and in the scanning approach had only a minimal effect on this value . Conclusion : The aortic regurgitant flow convergence is characterized by a relatively uniform V ( 7 mm ) /Q. Independent of variations in the anatomy and the scanning approach , this value directly reflects flow ." ], "offsets": [ [ 0, 1720 ] ] } ]

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[]

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ZfuerKardiologie.90880647.eng.abstr

[ { "id": "ZfuerKardiologie.90880647.eng.abstr-passage-0", "type": "abstract", "text": [ "Atrial fibrillation is in 20-50% the most frequent dysrhythmia after coronary artery bypass grafting ( CABG ) and a possible cause for hemodynamical complications and prolongation off the medical treatment in patients . Therefore , the effect of -blocking with metoprolol for prevention of supraventricular arrhythmias ( SVA ) was investigated in a prospective and randomized trial . 200 patients after CABG were randomized in a drug and control group ( average age 63.2 years , 154 male , 46 female ) . Patients of the drug group ( n=100) were treated with metoprolol ( 1mg/kg/BW) beginning on day one after operation , whereas patients of the control group ( n=100) received therapy only in case of occurrence of atrial fibrillaton . ECG , blood pressure , and electrolyte concentrations were measured regulary until the tenth day after surgery . Reasons for exclusion were an ejection fraction ( 30% , SA- and AV-block or simultaneous application of epinephrine and metoprolol . There were no significant differences between the patients of drug and control group with respect to age , sex ejection fraction , previous medication , number and type of bypass grafts , cardiopulmonary bypass time , and perioperative ischemic events . However , a statistically significant difference was seen in the occurrence of supraventricular arrhythmias in both groups , 4 patients of the therapy group ( 4% ) in contrast to 37 patients of the control ( 37% ) developed supraventricular arrhythmias during the postoperative observation period ( p 0.0001 ) . Both groups differed in total time of hospital stay by 1.5 days ( control group : 9.83 +/- 2.88 days ; drug group : 8.42 +/- 2.81 days ) , which was statistically significant ( p 0.05 ) . All patients of the drug group could be discharged with a stable sinusrhythm , whereas 7 patients of the control group were discharged with persistent atrial fibrillation . The difference was statistically significant as well ( p 0.01 ) . Neither typical side effects of metoprolol , nor AV-blocks , bradycardia ( f 60/min) or symptoms of low blood pressure could be observed . The conclusion of this trial is a recommendation for a preventive application of 50mg metoprolol/day after coronary artery bypass surgery , which can reduce the incidence of SVA as well as the hospital stay statistically significant ." ], "offsets": [ [ 0, 2348 ] ] } ]

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"id": "ZfuerKardiologie.90880647.eng.abstr-s1-t6", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 209, 217 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "Atrial fibrillation" ], "offsets": [ [ 0, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004238" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "coronary artery bypass" ], "offsets": [ [ 69, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010055" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "metoprolol" ], "offsets": [ [ 261, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025859" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "prevention" ], "offsets": [ [ 276, 286 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0687732" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "arrhythmias" ], "offsets": [ [ 307, 318 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003811" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 388, 396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "drug" ], "offsets": [ [ 429, 433 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "control" ], "offsets": [ [ 438, 445 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0243148" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "age" ], "offsets": [ [ 462, 465 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001792" }, { "db_name": "UMLS", "db_id": "C0001811" } ] }, { "id": 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"pressure" ], "offsets": [ [ 748, 756 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "electrolyte" ], "offsets": [ [ 763, 774 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013832" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "concentrations" ], "offsets": [ [ 775, 789 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s5-t6", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 839, 846 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.90880647.eng.abstr-s5-t7", "type": "umlsterm", "text": [ "blood pressure" ], "offsets": [ [ 742, 756 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005823" }, { "db_name": "UMLS", "db_id": "C0005824" } ] }, { "id": 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[]

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ZfuerKardiologie.90880653.eng.abstr

[ { "id": "ZfuerKardiologie.90880653.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the present study was to assess the effects of carvedilol therapy in addition to conventional heart failure therapy on heart rate variability ( HRV ) and on left ventricular function in 14 patients with mild to moderate heart failure due to idiopathic dilated cardiomyopathy ( IDC ) . After a 3- to 4-week titration period , carvedilol was titrated up to 50mg daily , or the highest dose tolerated ( at least 25mg daily ) . Maintenance treatment was then continued for 8 weeks . Digital 24-hour Holter recordings were obtained at baseline and after 8 weeks of carvedilol therapy . HRV for the entire 24-hour period was computed in the time domain using the Oxford Medilog Excel 2 analysis system . Measures of HRV included the mean of all coupling intervals between normal beats ( RRm ) , the standard deviation of all normal RR intervals ( SDNN ) , the square root of the mean of the squared differences between adjacent normal RR intervals ( rMSSD ) , and the proportion of adjacent normal RR intervals differing > 50ms ( pNN50)." ], "offsets": [ [ 0, 1042 ] ] } ]

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[]

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"ZfuerKardiologie.90880653.eng.abstr-s5-t3", "arg2_id": "ZfuerKardiologie.90880653.eng.abstr-s6-t1", "normalized": [] } ]

ZfuerKardiologie.90880661.eng.abstr

[ { "id": "ZfuerKardiologie.90880661.eng.abstr-passage-0", "type": "abstract", "text": [ "The treatment of carotid stenoses with balloon angioplasty and stenting is a new and not generally established method ." ], "offsets": [ [ 0, 119 ] ] } ]

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[]

ZfuerKardiologie.90880669.eng.abstr

[ { "id": "ZfuerKardiologie.90880669.eng.abstr-passage-0", "type": "abstract", "text": [ "The flow directed balloon-tipped pulmonary artery catheter introduced by Swann and Ganz 1970 has made possible the measurement of filling pressures in the heart and is extensively used in operating rooms , in catheterization laboratories and in intensive care units . The rupture of the pulmonary artery is an uncommon complication associated with a high mortality rate exceeding 50 percent . Main symptoms are cough , hemoptysis , dyspnea and cardiac shock . Complications occur if guidelines for the safe use of the balloon-tipped catheters are not strictly followed : Excessive catheter manipulation , advancing the catheter tip too far peripherally and leaving the inflated balloon in the wedge position for long periods should be avoided . Patients with pulmonary hypertension as well as elderly and anticoagulated patients are at greater risk ." ], "offsets": [ [ 0, 850 ] ] } ]

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"type": "umlsterm", "text": [ "catheterization" ], "offsets": [ [ 209, 224 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007430" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t7", "type": "umlsterm", "text": [ "laboratories" ], "offsets": [ [ 225, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022877" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t8", "type": "umlsterm", "text": [ "care" ], "offsets": [ [ 255, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0150499" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t9", "type": "umlsterm", "text": [ "pulmonary artery" ], "offsets": [ [ 33, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034052" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t10", "type": "umlsterm", "text": [ "operating rooms" ], "offsets": [ [ 188, 203 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029064" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t11", "type": "umlsterm", "text": [ "intensive care" ], "offsets": [ [ 245, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085559" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s1-t12", "type": "umlsterm", "text": [ "intensive care units" ], "offsets": [ [ 245, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021708" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "rupture" ], "offsets": [ [ 272, 279 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035955" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 297, 303 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "complication" ], "offsets": [ [ 319, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 355, 364 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "pulmonary artery" ], "offsets": [ [ 287, 303 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034052" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s2-t6", "type": "umlsterm", "text": [ "mortality rate" ], "offsets": [ [ 355, 369 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "symptoms" ], "offsets": [ [ 398, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0683368" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "cough" ], "offsets": [ [ 411, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010200" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "hemoptysis" ], "offsets": [ [ 419, 429 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019079" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s3-t4", "type": "umlsterm", "text": [ "dyspnea" ], "offsets": [ [ 432, 439 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013404" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s3-t5", "type": "umlsterm", "text": [ "shock" ], "offsets": [ [ 452, 457 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036974" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "Complications" ], "offsets": [ [ 460, 473 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "guidelines" ], "offsets": [ [ 483, 493 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220845" }, { "db_name": "UMLS", "db_id": "C0162791" }, { "db_name": "UMLS", "db_id": "C0282423" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "use" ], "offsets": [ [ 507, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "catheters" ], "offsets": [ [ 533, 542 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085590" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "catheter" ], "offsets": [ [ 581, 589 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085590" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "catheter" ], "offsets": [ [ 619, 627 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085590" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "tip" ], "offsets": [ [ 628, 631 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0339897" } ] }, { "id": "ZfuerKardiologie.90880669.eng.abstr-s4-t8", "type": "umlsterm", "text": [ "periods" ], "offsets": [ [ 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[]

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ZfuerKardiologie.90880675.eng.abstr

[ { "id": "ZfuerKardiologie.90880675.eng.abstr-passage-0", "type": "abstract", "text": [ "A 49 year old male developed cardiocirculatory arrest following laparoscopic surgery of an inguinal hernia . Cardiopulmonary resuscitation ( CPR ) was started . The primary ECG showed ventricular fibrillation , after defibrillation a tachyarrhythmia and a newly developed right bundle branch block were documented . In addition , ST-elevations were seen in the left precordial leads . After 20 min of CPR the circulation was reestablished with high doses of catecholamines . Transthoracic echocardiography demonstrated a 7 mm pericardial effusion with mild impression of the right ventricular free wall . The patient underwent urgent heart catheterization for suspected pulmonary embolism ( differential diagnosis : acute myocardial infarction ) . Pulmonary angiography demonstrated floating thrombi in the left main pulmonary artery , which could be fragmented using a pigtail catheter . Pulmonary angiography was followed by coronary angiography , which demonstrated a sharply interrupted left anterior descending artery ( LAD ) , while the coronary arteries in general were found to be regular . The history , the morphology of the LAD-interruption , the concomitant pericardial effusion and the sternal and rib fractures were consistent with a type III coronary perforation in the classification of Sutton and Ellis . As contrast medium penetration into the pericardial space persisted after recanalization of the LAD , a 19 mm stent graft ( Jostent ) was used for closure . These grafts are constructed using a sandwich technique with an ultrathin layer of expandable polytetrafluorethylene being placed between two stents . After implantation of the stent graft no more contrast medium penetration was documented ." ], "offsets": [ [ 0, 1720 ] ] } ]

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[]

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ZfuerKardiologie.90880773.eng.abstr

[ { "id": "ZfuerKardiologie.90880773.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the study was to compare the mean and maximum flow and the flow pattern of coronary vein grafts ( SVG ) supplying target vessels of the inferior and lateral wall with internal mammary ( IMA ) grafts to the left anterior descending artery ( LAD ) . In 21 patients 25 bypass grafts ( 13/25 SVG , 12/25 IMA ) were investigated . Using the transit time ultrasound method , flow was measured every 5 ms and the flow data of 60 s were acquired . The flow pattern showed significant differences between both graft types during their cycle . IMA grafts showed only one peak occurring after 22.1 +/- 12.3% and the second after 63.4 +/- 15.5% of their cycle . The mean flow was not different in both graft types ( IMA : 45.3 +/- 27.0 ml/min and SVG : 41.8 +/- 26.7 ml/min , p = n . s. ) as it was the case for the maximum flow ( IMS : 98.4 +/- 45.2 ml/min and SVG : 75.7 +/- 55.4 ml/min , p = n . s. ) . In conclusion , there is a different flow pattern for both graft types concerning the number and the occurrence of flow-peaks in the bypass cycle . The mean and peak flow showed no significant difference ." ], "offsets": [ [ 0, 1110 ] ] } ]

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[]

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ZfuerKardiologie.90880788.eng.abstr

[ { "id": "ZfuerKardiologie.90880788.eng.abstr-passage-0", "type": "abstract", "text": [ "Coronary surgery is at this point of time the standard therapy of unprotected left main coronary artery stenosis . Coronary angioplasty ( PTCA ) is performed only in bail out situations . The number of publications of successful percutaneous intervention in unprotected left main coronary stenosis is increasing because of increasing use of stents and ticlopidine to avoid stent-thrombosis ." ], "offsets": [ [ 0, 391 ] ] } ]

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[]

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ZfuerKardiologie.90880795.eng.abstr

[ { "id": "ZfuerKardiologie.90880795.eng.abstr-passage-0", "type": "abstract", "text": [ "Objectives : Two third of patients with acute myocardial infarction are admitted to hospitals without cardiac catheterization facilities . Whether a postinfarction patient will undergo cardiac catheterization or not is more often decided by general physicians than by cardiologists . The purpose of this presentation is to investigate the determinants for decision making to use cardiac catheterization in patients after myocardial infarction ." ], "offsets": [ [ 0, 444 ] ] } ]

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[]

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ZfuerKardiologie.90880802.eng.abstr

[ { "id": "ZfuerKardiologie.90880802.eng.abstr-passage-0", "type": "abstract", "text": [ "Assessment of the myocardial contractility in terms of the velocity of circumferential fiber shortening appropriate to the actual left ventricular endsystolic wall stress requires endsystolic pressure measurement usually done invasively . But for noninvasive evaluation of this parameter , we elaborated an algorithm to derive the endsystolic pressure in the ascending aorta from oscillometric blood pressure measurements ." ], "offsets": [ [ 0, 423 ] ] } ]

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[]

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ZfuerKardiologie.90880815.eng.abstr

[ { "id": "ZfuerKardiologie.90880815.eng.abstr-passage-0", "type": "abstract", "text": [ "Antitachycardia pacing techniques ( ATP ) have proved useful for termination of ventricular tachycardia ( VT ) . However , little is known about the efficacy and safety off ATP during long-term follow-up in a larger study population . We analyzed the data of 80 ICD patients ( pts ) with spontaneous monormorphic VT , mean age 59 +/- 12 years , the mean follow-up was 26 +/- 17 months . 50 pts ( 62.5% ) had coronary artery disease , 18 ( 22.5% ) dilative cardiomyopathy ( DCM ) , the remaining 12 pts ( 15% ) had no or other cardiac diseases . 2926 episodes of ventricular tachycardia ( cycle length 349 +/- 51 ms , 240-520 ms ) occurred in 64/80 pts ( 80% ) , overall efficacy of ATP was 89.9% , acceleration occurred in 4.1% of VTs . Success of ATP did not correlate with positive ATP testing on induced arrhythmias , LVEF , NYHA class or aneurysm . Neither underlying heart disease nor antiarrhythmic medication had an impact on the ATP success rate . ATP efficacy was linked significantly to short VT cycle length ( VTCL , 240-300 ms , p 0.01 ) and long coupling intervals ( 91-97% ) , p 0.01 ) . Acceleration occurred in 32% of pts and in 4.1% of VT episodes ; it was also dependent on short VT cycle length ( 300 ms vs > 300 ms , p 0.04 ) and short coupling intervals ( 81% vs > = 81% , p = 0.01 ) ." ], "offsets": [ [ 0, 1306 ] ] } ]

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[]

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]

ZfuerKardiologie.90880823.eng.abstr

[ { "id": "ZfuerKardiologie.90880823.eng.abstr-passage-0", "type": "abstract", "text": [ "The aim of the study was to compare the clinical outcome after AV node radiofrequency current ablation and pacemaker implantation in patients with permanent and paroxysmal atrial fibrillation . The study consecutively included 19 patients with permanent ( male n = 15 ; 55 +/- 13 years ) and 45 patients with paroxysmal atrial fibrillation ( male n = 31 ; 60 +/- 13 years ) . Clinical evaluation before and 1 year after ablation included the symptoms and the self-assessed state of health . Before ablation , both groups reported with a similar frequency about tachycardia ( permanent n = 15 ; paroxysmal n = 2 ) and palpitations ( permanent n = 5 ; paroxysmal n = 19 ) . Patients with permanent ( n = 7 ) atrial fibrillation had more often breathlessness than patients with paroxysmal atrial fibrillation ( n = 2 ) , whereas dizziness/syncope was more often reported by patients with paroxysmal ( n = 35 ) than with permanent arrhythmia ( n = 8 ) . Ablation improved symptoms in patients with permanent ( 89% ) as well as with paroxysmal atrial fibrillation ( 84% ) . The self-assessed state of health described as good had not patient before ablation and 63% patients with permanent and 47% with paroxysmal atrial fibrillation after ablation . There were no differences for the studied parameters between patients with permanent and paroxysmal atrial fibrillation ." ], "offsets": [ [ 0, 1367 ] ] } ]

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[]

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ZfuerKardiologie.90880828.eng.abstr

[ { "id": "ZfuerKardiologie.90880828.eng.abstr-passage-0", "type": "abstract", "text": [ "While the cellular mechanisms of atherosclerosis have been intensively studied , the mechanisms leading to preferential localization of atherosclerotic lesions are less well understood . To further define these mechanisms , endothelial cells from coronary arteries , i.e. , vessels with frequent atheroscleritic lesions , were isolated and grown in vitro . In order to compare the reactions of both cell types , endothelial cells derived from microvessels of human hearts were isolated and cultured under identical conditions . Incubation of endothelial cells with oxidized LDL ( 75 µg/ml protein ) induced a significant increase in PAI-1 activity ( 182% , p 0.05 ) in coronary macrovascular endothelial cells . This stimulatory effect of ox-LDL was less significant in microvascular endothelial cells ( 144% , p 0.05 ) . n-LDL did not influence secreted PAI-1 activity . Stimulation with angiotensin II induced expression of E-selectin more effectively in coronary macrovascular than in microvascular endothelial cells . In addition , angiotensin II-induced E-selectin espression led to incresed E-selectin-dependent adhesion of HL60 cells to coronary macrovascular endothelial cells under flow conditions , while only little effect was observed with cardiac microvascular endothelial cells . In contrast , L-selectin-dependent adhesion , which has been shown to play an important role in inflammatory reactions , was preferentially observed in cardiac microvascular endothelial cells and could only be stimulated with TNF , not by angiotensin II . Therefore , these cellular differences may in part explain specific properties of cardiac endothelial cells : Such that atherosclerotic lesions are localized in macrovascular vessel segments , whereas inflammatory responses are predominantly found in the microvasculature ." ], "offsets": [ [ 0, 1823 ] ] } ]

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"umlsterm", "text": [ "LDL" ], "offsets": [ [ 574, 577 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023823" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "protein" ], "offsets": [ [ 589, 596 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "PAI-1" ], "offsets": [ [ 633, 638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030190" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 704, 709 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "oxidized LDL" ], "offsets": [ [ 565, 577 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348035" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "ox-LDL" ], "offsets": [ [ 739, 745 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"C0007634" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s7-t4", "type": "umlsterm", "text": [ "angiotensin II" ], "offsets": [ [ 889, 903 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003009" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s8-t1", "type": "umlsterm", "text": [ "angiotensin" ], "offsets": [ [ 1036, 1047 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003018" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s8-t2", "type": "umlsterm", "text": [ "E-selectin" ], "offsets": [ [ 1059, 1069 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0115305" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s8-t3", "type": "umlsterm", "text": [ "adhesion" ], "offsets": [ [ 1118, 1126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001511" } ] }, { "id": "ZfuerKardiologie.90880828.eng.abstr-s8-t4", "type": "umlsterm", "text": [ "cells" ], "offsets": [ [ 1135, 1140 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": 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[]

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ZfuerKardiologie.90880838.eng.abstr

[ { "id": "ZfuerKardiologie.90880838.eng.abstr-passage-0", "type": "abstract", "text": [ "Background : Clinical drawbacks of beta-blocker treatment in stable angina have motivated researchers to provide alternative heart rat lowering agents , such as tedisamil which additionally exerts antiischemic and antiarrhythmic effects by blockade of cellular repolarizing K+ currents ." ], "offsets": [ [ 0, 287 ] ] } ]

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[]

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ZfuerKardiologie.90880850.eng.abstr

[ { "id": "ZfuerKardiologie.90880850.eng.abstr-passage-0", "type": "abstract", "text": [ "We report about a 17 year old male patient with a cardiomyopathy secondary to type IV glycogenosis ( Andersens disease ) and class II immunoglobulin deficiency who underwent cardiac transplantation ." ], "offsets": [ [ 0, 199 ] ] } ]

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[]

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[] }, { "id": "ZfuerKardiologie.90880850.eng.abstr-s1-r84-t8.1-t5.1", "type": "indicates", "arg1_id": "ZfuerKardiologie.90880850.eng.abstr-s1-t8", "arg2_id": "ZfuerKardiologie.90880850.eng.abstr-s1-t5", "normalized": [] } ]

ZfuerKardiologie.90880868.eng.abstr

[ { "id": "ZfuerKardiologie.90880868.eng.abstr-passage-0", "type": "abstract", "text": [ "Patients who have undergone coronary artery bypass grafting may develop acute myocardial infarction late after surgery . It is not exactly known in these patients whether acute infarction is predominantly caused by occlusion of bypass or native vessels . Also , there is no systematic and prospective data available with respect to an invasive , revascularizing therapeutic approach . Therefore , acute coronary angiograms were obtained in 21 consecutive patients with acute infarctions and remote bypass grafting to elucidate mechanisms causing myocardial infarction in these patients , and to assess results of catheter-based recanalization ." ], "offsets": [ [ 0, 644 ] ] } ]

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[]

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ZfuerKardiologie.90880885.eng.abstr

[ { "id": "ZfuerKardiologie.90880885.eng.abstr-passage-0", "type": "abstract", "text": [ "Several studies have demonstrated an association Chlamydia pneumoniae with coronary artery disease , suggesting that infection with C. pneumoniae increases the risk for coronary artery disease by factor 2 or more . Since atherosclerosis is considered to be a chronic inflammatory process , these data would fit into the response-to-injury hypothesis of atherosclerosis rather than representing a completely novel concept . Several pathomechanisms as increased cytokine synthesis , proliferative and proaggregatory effects could transmit the effects of chronic C. pneumoniae infection . Animal models and first clinical trials using antibiotic therapy seem to support an etiological role of C. pneumoniae in coronary artery disease . In this paper the current knowledge of the role of C- pneumoniae in coronary artery disease is reviewed and possible pathomechanisms are discussed ." ], "offsets": [ [ 0, 881 ] ] } ]

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[]

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ZfuerKardiologie.90880896.eng.abstr

[ { "id": "ZfuerKardiologie.90880896.eng.abstr-passage-0", "type": "abstract", "text": [ "Aims : An in vitro study of the flow convergence region in aortic regurgitation has shown that regurgitant flow rate can be derived from the local velocity v ( 7 mm ) at 7 mm distance above the leak orifice . This clinical study was performed to test this method in patients ." ], "offsets": [ [ 0, 276 ] ] } ]

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[]

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ZfuerKardiologie.90880906.eng.abstr

[ { "id": "ZfuerKardiologie.90880906.eng.abstr-passage-0", "type": "abstract", "text": [ "Introduction : The Pura-Vario stent features 2 newly designed \" bridging segments \" for enhanced longitudinal flexibility , in order to allow easier and safer stent implantation ." ], "offsets": [ [ 0, 179 ] ] } ]

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[]

ZfuerKardiologie.90880922.eng.abstr

[ { "id": "ZfuerKardiologie.90880922.eng.abstr-passage-0", "type": "abstract", "text": [ "Conventional echocardiographic methods of measuring left ventricular mass ( LVM ) are limited by assumptions of ventricular geometry and image plane positioning . Three-dimensional ( 3D ) echocardiography offers a promising new approach for more accurate determination of LVM . This study was performed to compare LVM measurement by one- ( 1D ) , two- ( 2D ) , and 3D echocardiography with magnetic resonance imaging ( MRI ) in patients ( pts ) with dilated cardiomyopathy ( DCM ) ." ], "offsets": [ [ 0, 482 ] ] } ]

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[]

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ZfuerKardiologie.90880932.eng.abstr

[ { "id": "ZfuerKardiologie.90880932.eng.abstr-passage-0", "type": "abstract", "text": [ "With the increasing use of cross-sectional echocardiography in patients with overt or suspected pulmonary thromboembolism in the emergency rooms , more and more right atrial thrombi are detected . These are so-called \" transitthrombi \" from the venous system on their way to the pulmonary arteries and they are a severe presentation of thromboembolic disease . They appear as an imminent pulmonary embolism and usually coexists with an already massive embolism . In patients were a right atrial thrombus is associated with a patent foramen ovale , paradoxical arterial embolism has been observed . Right sided heart thrombi have a high mortality rate and need immediate treatment . In our hospital we have seen 14 patients with right atrial thrombi and pulmonary embolism in a period of 6 years . Three patients had cardiac arrest with a massive pulmonary embolism , seven patients presented with a submassive embolism . All patients were treated immediately after echocardiographic diagnosis without pulmonary angiography . In about half of the cases transesophageal echocardiography was done additionally for diagnosis and monitoring . Therapeutic options were thrombectomy , fibrinolysis or anticoagulants . We treated one of our patients with thrombectomy , eleven patients with fibrinolysis and two patients with anticoagulants ." ], "offsets": [ [ 0, 1334 ] ] } ]

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"umlsterm", "text": [ "pulmonary arteries" ], "offsets": [ [ 279, 297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034052" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s3-t1", "type": "umlsterm", "text": [ "embolism" ], "offsets": [ [ 398, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013922" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s3-t2", "type": "umlsterm", "text": [ "embolism" ], "offsets": [ [ 452, 460 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013922" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s3-t3", "type": "umlsterm", "text": [ "pulmonary embolism" ], "offsets": [ [ 388, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034065" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t1", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 466, 474 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "right" ], "offsets": [ [ 482, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035621" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "thrombus" ], "offsets": [ [ 495, 503 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087086" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t4", "type": "umlsterm", "text": [ "patent" ], "offsets": [ [ 525, 531 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030650" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t5", "type": "umlsterm", "text": [ "embolism" ], "offsets": [ [ 569, 577 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013922" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t6", "type": "umlsterm", "text": [ "foramen ovale" ], "offsets": [ [ 532, 545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016521" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s4-t7", "type": "umlsterm", "text": [ "patent foramen ovale" ], "offsets": [ [ 525, 545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016522" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Right" ], "offsets": [ [ 598, 603 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035621" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "heart" ], "offsets": [ [ 610, 615 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "thrombi" ], "offsets": [ [ 616, 623 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087086" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "mortality" ], "offsets": [ [ 636, 645 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026566" }, { "db_name": "UMLS", "db_id": "C0026565" } ] }, { "id": "ZfuerKardiologie.90880932.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 670, 679 ] ], 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[]

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ZfuerKardiologie.90880941.eng.abstr

[ { "id": "ZfuerKardiologie.90880941.eng.abstr-passage-0", "type": "abstract", "text": [ "There is a significantly higher incidence of cerebral ischemia among patients with an atrial septal aneurysm and/or a patent foramen ovale . According to the information provided by modern diagnostic procedures - and in particular by transesophageal echocardiography - two pathogenic mechanisms should be considered as possible causes of the cerebral ischemia . Thrombi may develop locally in the left atrium or atrial septal aneurysm and lead to embolization or , alternatively , thrombi from the inflow region of the inferior vena cava may become trapped in the atrial septal aneurysm and pass through the patent foramen ovale to bring about embolization in the arterial bloodstream . Current treatment consists of life-long anticoagulation with cumarin derivatives in order to prevent further neurological complications . With this treatment , however , the risk of producing hemorrhages cannot be regarded as trivial , especially in old people ." ], "offsets": [ [ 0, 949 ] ] } ]

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[]

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{ "id": "ZfuerKardiologie.90880941.eng.abstr-s5-r5-t6.1-t1.1", "type": "evaluation_of", "arg1_id": "ZfuerKardiologie.90880941.eng.abstr-s5-t6", "arg2_id": "ZfuerKardiologie.90880941.eng.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880941.eng.abstr-s5-r6-t4.1-t1.1", "type": "performs", "arg1_id": "ZfuerKardiologie.90880941.eng.abstr-s5-t4", "arg2_id": "ZfuerKardiologie.90880941.eng.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880941.eng.abstr-s5-r7-t6.1-t1.1", "type": "conceptual_part_of", "arg1_id": "ZfuerKardiologie.90880941.eng.abstr-s5-t6", "arg2_id": "ZfuerKardiologie.90880941.eng.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerKardiologie.90880941.eng.abstr-s5-r8-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerKardiologie.90880941.eng.abstr-s5-t1", "arg2_id": "ZfuerKardiologie.90880941.eng.abstr-s5-t3", "normalized": [] } ]

ZfuerKardiologie.90880948.eng.abstr

[ { "id": "ZfuerKardiologie.90880948.eng.abstr-passage-0", "type": "abstract", "text": [ "We describe a 71-year-old man with a history of a small posterior myocardial infarction . Angiographically he showed a coronary artery disease with major proximal stenosis of both branches of the left coronary artery and an occlusion of the marginal branch of the circumflex artery ( infarct-related vessel ) . As an unexpected finding , an anomalous origin of the right coronary artery from the pulmonary artery was also found . This rare condition may cause development of ischemia with potentially lethal complications as a result of coronary steal phenomenon . Surgical treatment is , therefore , indicated even in asymptomatic patients with this anomaly . Possible surgical procedures and there indications are discussed ." ], "offsets": [ [ 0, 727 ] ] } ]

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"db_name": "UMLS", "db_id": "C0027051" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t1", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 128, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t2", "type": "umlsterm", "text": [ "disease" ], "offsets": [ [ 135, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t3", "type": "umlsterm", "text": [ "stenosis" ], "offsets": [ [ 163, 171 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009814" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t4", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 210, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s2-t5", "type": "umlsterm", "text": [ "artery" ], "offsets": [ [ 275, 281 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003842" } ] }, { "id": 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{ "id": "ZfuerKardiologie.90880948.eng.abstr-s4-t2", "type": "umlsterm", "text": [ "ischemia" ], "offsets": [ [ 475, 483 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022116" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s4-t3", "type": "umlsterm", "text": [ "complications" ], "offsets": [ [ 508, 521 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s5-t1", "type": "umlsterm", "text": [ "Surgical" ], "offsets": [ [ 565, 573 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s5-t2", "type": "umlsterm", "text": [ "treatment" ], "offsets": [ [ 574, 583 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0087111" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s5-t3", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 632, 640 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s5-t4", "type": "umlsterm", "text": [ "anomaly" ], "offsets": [ [ 651, 658 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000769" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s5-t5", "type": "umlsterm", "text": [ "Surgical treatment" ], "offsets": [ [ 565, 583 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s6-t1", "type": "umlsterm", "text": [ "surgical" ], "offsets": [ [ 670, 678 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038895" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s6-t2", "type": "umlsterm", "text": [ "procedures" ], "offsets": [ [ 679, 689 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0184661" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.90880948.eng.abstr-s6-t3", "type": "umlsterm", "text": [ "surgical procedures" ], "offsets": [ [ 670, 689 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0543467" } ] } ]

[]

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ZfuerKardiologie.90880974.eng.abstr

[ { "id": "ZfuerKardiologie.90880974.eng.abstr-passage-0", "type": "abstract", "text": [ "Primary prevention of sudden cardiac death is hampered by the inability to accurately identify high risk patients . Various noninvasive methods such as determination of left ventricular function or heart rate variability as well as invasive electrophysiologic testing are currently used for risk stratification . Noninvasive measurement of microvolt T wave alternans ( TWA ) is a promising new method to assess repolarization abnormalities ; in experimental studies , TWA was associated with an increased incidence of ventricular tachyarrhythmias . Since the occurrence of TWA is heart rate-dependent , it is measured either during atrial pacing or during exercise stress testing . The first clinical validation of the method was performed in patients undergoing invasive EP testing to assess prediction of inducibility of ventricular tachyarrhythmias . A first prospective validation of the noninvasive method was performed in patients surviving out-of-hospital cardiac arrest fitted with an ICD . Further studies have shown a good concordance between invasive and noninvasive TWA determination . The occurrence of TWA in this population was of predictive value with respect to arrhythmia recurrence . Recently published data confirm the value of TWA assessment with respect to identification of patients with congestive heart failure at high risk of malignant ventricular tachyarrhythmias . The use of this method in post myocardial infarction risk stratification is currently under prospective evaluation ." ], "offsets": [ [ 0, 1509 ] ] } ]

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[]

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ZfuerKardiologie.90880982.eng.abstr

[ { "id": "ZfuerKardiologie.90880982.eng.abstr-passage-0", "type": "abstract", "text": [ "Hospital mortality from acute myocardial infarction has decreased in the last two decades . Left ventricular dysfunction therefore have been mainly due to ischemia . After extensive myocardial infarction , there are processes of adaptation ( remodeling ) which result in altered geometry of the left ventricle . The effects of this on neurohormonal systems ( organ regulation ) , on the changed ratio of myocyte mass and collagen content owing to reactive and reparative fibrosis ( organ texture ) and on the molecular and cellular mechanisms ( organ structure ) are of crucial importance . Depending on the structural changes , the myocardial contractility decreases . This associated with an activation of the circulating renin-angiotensin-aldosterone system ( RAAS ) ." ], "offsets": [ [ 0, 771 ] ] } ]

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[]

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ZfuerKardiologie.90880991.eng.abstr

[ { "id": "ZfuerKardiologie.90880991.eng.abstr-passage-0", "type": "abstract", "text": [ "Cardiovascular diseases are the major cause of death not only in Germany . Coronary heart diseases result in substantial disability and loss of productivity and contribute to escalating costs of health care . Objective : It was out objective to estimate the costs of CHD for the German population from the perspective of the society . The characteristic of this approach is the calculating of costs until the approximated end of life . Methods : In the study , all health care costs concerning CHD in Germany were allocated to age , sex , health care sector and primary diagnosis on the basis of comprehensive data on morbidity , mortality , direct and indirect costs . For the estimate of indirect costs the human capital approach was taken . Considered as cases were all patients hospitalized in the reference year ( 1996 ) . The costs of this cohort in 1996 and up to their protected end of life were estimated . It was taken into account that , in comparison to the general population , life expectancy of cases with risk factors of CHD would have been reduced . In calculating indirect costs , gender and age specific unemployment rates were considered . All future costs were discounted by 4% from the reference year onward . Results : Direct costs are approximately 39 billion DM discounted at 4% , indirect costs total 73 billion DM . The average cost per case ( including morbiditiy and mortality ) until the approximated end of life is nearly 125,000 DM . Conclusion : In our cost analysis , the indirect costs are higher than the direct costs . For the future , it will be important to estimate the costs of prevalent cases until the end of life and to compare the influence of different interventions on these parameters and on the whole budget of the social security system ." ], "offsets": [ [ 0, 1788 ] ] } ]

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ZfuerKardiologie.90881001.eng.abstr

[ { "id": "ZfuerKardiologie.90881001.eng.abstr-passage-0", "type": "abstract", "text": [ "One-hundred-thirty patients underwent 53 electrophysiological studies including programmed atrial and ventricular stimulation and 96 atrial overdrive stimulations on an outpatient basis . The indications for electrophysiological study were disabling palpitation , syncope , or presyncope , intracardiac conduction disturbance , and bradyarrhythmia . In one patient the efficacy of oral antiarrhythmic drug therapy was evaluated by repeat electrophysiological study . Atrial overdrive stimulation was performed in patients with atrial flutter or atrial tachycardia . On the basis of the result of electrophysiological testing , 25 patients were believed not to require any treatment , 16 patients received new drug therapy , 7 patients underwent catheter ablation in a second session , 2 patients had either a pacemaker or an ICD implanted , and 1 patient continued to receive the drug therapy that had been tested . Atrial overdrive stimulation resulted in a regular sinus rhythm in 66 patients ( 69% ) . Except for one patient in whom atrial flutter could not be terminated , atrial fibrillation was induced in the remaining 30 patients . After the procedure , patients were monitored for 30 min in case of overdrive stimulation , and for approximately 3 h after electrophysiological study or 6 h if additional coronary angiography had been performed . Severe complications were not observed . In 10 cases minor hematoma occurred at the puncture site without serious sequelae . - Outpatients electrophysiological study as well as atrial overdrive stimulation are feasible and safe in a selected group of patients ." ], "offsets": [ [ 0, 1615 ] ] } ]

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[]

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"id": "ZfuerKardiologie.90881001.eng.abstr-s10-r3-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerKardiologie.90881001.eng.abstr-s11-t1", "arg2_id": "ZfuerKardiologie.90881001.eng.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerKardiologie.90881001.eng.abstr-s10-r4-t4.1-t3.1", "type": "evaluation_of", "arg1_id": "ZfuerKardiologie.90881001.eng.abstr-s10-t4", "arg2_id": "ZfuerKardiologie.90881001.eng.abstr-s10-t3", "normalized": [] } ]

ZfuerKardiologie.90881006.eng.abstr

[ { "id": "ZfuerKardiologie.90881006.eng.abstr-passage-0", "type": "abstract", "text": [ "Purpose : To describe the radiographic appearance of the Gianturco and the Cook detachable coils and present the clinical results in patients who underwent transcatheter closure of patent ductus arteriosus ." ], "offsets": [ [ 0, 207 ] ] } ]

[ { "id": "ZfuerKardiologie.90881006.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "Cook" ], "offsets": [ [ 75, 79 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0335326" } ] }, { "id": "ZfuerKardiologie.90881006.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "patients" ], "offsets": [ [ 133, 141 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerKardiologie.90881006.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "patent" ], "offsets": [ [ 181, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030650" } ] }, { "id": "ZfuerKardiologie.90881006.eng.abstr-s1-t4", "type": "umlsterm", "text": [ "ductus arteriosus" ], "offsets": [ [ 188, 205 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013273" } ] }, { "id": "ZfuerKardiologie.90881006.eng.abstr-s1-t5", "type": "umlsterm", "text": [ "patent ductus arteriosus" ], "offsets": [ [ 181, 205 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013274" } ] } ]

[]

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ZfuerKardiologie.90881023.eng.abstr

[ { "id": "ZfuerKardiologie.90881023.eng.abstr-passage-0", "type": "abstract", "text": [ "The localized dissection of the aortic sinus of valsalvae is a rare complication of coronary angioplasty involving mainly the right coronary artery . In all previously published case reports ( n = 10 ) , a coronary dissection provided the entry door with subsequent retrograde progression of the dissection into the aortic root ." ], "offsets": [ [ 0, 329 ] ] } ]

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[]

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ZfuerKardiologie.90881028.eng.abstr

[ { "id": "ZfuerKardiologie.90881028.eng.abstr-passage-0", "type": "abstract", "text": [ "An echinococcal cyst of the heart is a rare cause of acute cardiac tamponade . We report on a 24 year old male from the Kosovo who was brought in an emergency state from a provincial hospital complaining of severe dyspnea , thoracic pain , dizziness , and a short period of unconsciousness . Surgical decompression had to be performed urgently , because the pericardium could not be punctuated due to the position of the hydatid cyst ." ], "offsets": [ [ 0, 435 ] ] } ]

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[]

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ZfuerKardiologie.9088s002.eng.abstr

[ { "id": "ZfuerKardiologie.9088s002.eng.abstr-passage-0", "type": "abstract", "text": [ "The value of minimally invasive techniques in relation to conventional coronary surgery is not clearly established and frequently very controversially discussed ." ], "offsets": [ [ 0, 162 ] ] } ]

[ { "id": "ZfuerKardiologie.9088s002.eng.abstr-s1-t1", "type": "umlsterm", "text": [ "value" ], "offsets": [ [ 4, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042295" } ] }, { "id": "ZfuerKardiologie.9088s002.eng.abstr-s1-t2", "type": "umlsterm", "text": [ "techniques" ], "offsets": [ [ 32, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerKardiologie.9088s002.eng.abstr-s1-t3", "type": "umlsterm", "text": [ "surgery" ], "offsets": [ [ 80, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038894" }, { "db_name": "UMLS", "db_id": "C0038895" } ] } ]

[]

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ZfuerKardiologie.9088s017.eng.abstr

[ { "id": "ZfuerKardiologie.9088s017.eng.abstr-passage-0", "type": "abstract", "text": [ "Multi-vessel coronary artery bypass grafting through a left anterior small thoracotomy is a rarely performed procedure due to the impaired accessibility of the aorta as well as the complete coronary anatomy . Because of additional contraindications in using the Port-Access system , this surgical method is not well recognized among the numerous techniques in minimally invasive cardiac surgery ." ], "offsets": [ [ 0, 396 ] ] } ]

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[]

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ZfuerKardiologie.9088s024.eng.abstr

[ { "id": "ZfuerKardiologie.9088s024.eng.abstr-passage-0", "type": "abstract", "text": [ "The development of new cardiopulmonary bypass technologies , special surgical instruments , as well as intrathoracic video systems facilitates mitral surgery via a small right thoracotomy ." ], "offsets": [ [ 0, 189 ] ] } ]

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[]

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