LMEB: Long-horizon Memory Embedding Benchmark
Paper • 2603.12572 • Published • 73
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33370_0 | Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
33370_1 | GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
33370_2 | We determined that A20 (TNFAIP3), a regulator of cell survival and the NF-kappaB pathway, is overexpressed in GSCs relative to non-stem glioblastoma cells at both the mRNA and protein levels. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
33370_3 | To determine the functional significance of A20 in GSCs, we targeted A20 expression with lentiviral-mediated delivery of short hairpin RNA (shRNA). | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
33370_4 | Inhibiting A20 expression decreased GSC growth and survival through mechanisms associated with decreased cell-cycle progression and decreased phosphorylation of p65/RelA. Elevated levels of A20 in GSCs contributed to apoptotic resistance: GSCs were less susceptible to TNFalpha-induced cell death than matched non-stem g... | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
33370_5 | The decreased survival of GSCs upon A20 knockdown contributed to the reduced ability of these cells to self-renew in primary and secondary neurosphere formation assays. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
33370_6 | The tumorigenic potential of GSCs was decreased with A20 targeting, resulting in increased survival of mice bearing human glioma xenografts. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
33370_7 | In silico analysis of a glioma patient genomic database indicates that A20 overexpression and amplification is inversely correlated with survival. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
33370_8 | Together these data indicate that A20 contributes to glioma maintenance through effects on the glioma stem cell subpopulation. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
33370_9 | Although inactivating mutations in A20 in lymphoma suggest A20 can act as a tumor suppressor, similar point mutations have not been identified through glioma genomic sequencing: in fact, our data suggest A20 may function as a tumor enhancer in glioma through promotion of GSC survival. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
33370_10 | A20 anticancer therapies should therefore be viewed with caution as effects will likely differ depending on the tumor type. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth |
123859_0 | Podocytes are critical in the maintenance of a healthy glomerular filter; however, they have been difficult to study in the intact kidney because of technical limitations. | Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in novel mouse models with fluorescent lineage tags |
123859_1 | Here we report the development of serial multiphoton microscopy (MPM) of the same glomeruli over several days to visualize the motility of podocytes and parietal epithelial cells (PECs) in vivo. | Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in novel mouse models with fluorescent lineage tags |
123859_2 | In podocin-GFP mice, podocytes formed sporadic multicellular clusters after unilateral ureteral ligation and migrated into the parietal Bowman's capsule. | Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in novel mouse models with fluorescent lineage tags |
123859_3 | The tracking of single cells in podocin-confetti mice featuring cell-specific expression of CFP, GFP, YFP or RFP revealed the simultaneous migration of multiple podocytes. | Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in novel mouse models with fluorescent lineage tags |
123859_4 | In phosphoenolpyruvate carboxykinase (PEPCK)-GFP mice, serial MPM found PEC-to-podocyte migration and nanotubule connections. | Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in novel mouse models with fluorescent lineage tags |
123859_5 | Our data support a highly dynamic rather than a static nature of the glomerular environment and cellular composition. | Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in novel mouse models with fluorescent lineage tags |
123859_6 | Future application of this new approach should advance our understanding of the mechanisms of glomerular injury and regeneration. | Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in novel mouse models with fluorescent lineage tags |
306006_0 | T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands. | The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. |
306006_1 | The factors that determine the stimulatory potency of a pMHC molecule remain unclear. | The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. |
306006_2 | We describe results showing that a peptide exhibiting many hallmarks of a weak agonist stimulates T cells to proliferate more than the wild-type agonist ligand. | The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. |
306006_3 | An in silico approach suggested that the inability to form the central supramolecular activation cluster (cSMAC) could underlie the increased proliferation. | The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. |
306006_4 | This conclusion was supported by experiments that showed that enhancing cSMAC formation reduced stimulatory capacity of the weak peptide. | The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. |
306006_5 | Our studies highlight the fact that a complex interplay of factors determines the quality of a T cell antigen. | The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. |
464511_0 | Genetically identical cells sharing an environment can display markedly different phenotypes. | Memory and Modularity in Cell-Fate Decision Making |
464511_1 | It is often unclear how much of this variation derives from chance, external signals, or attempts by individual cells to exert autonomous phenotypic programs. | Memory and Modularity in Cell-Fate Decision Making |
464511_2 | By observing thousands of cells for hundreds of consecutive generations under constant conditions, we dissect the stochastic decision between a solitary, motile state and a chained, sessile state in Bacillus subtilis. | Memory and Modularity in Cell-Fate Decision Making |
464511_3 | We show that the motile state is 'memoryless', exhibiting no autonomous control over the time spent in the state. | Memory and Modularity in Cell-Fate Decision Making |
464511_4 | In contrast, the time spent as connected chains of cells is tightly controlled, enforcing coordination among related cells in the multicellular state. | Memory and Modularity in Cell-Fate Decision Making |
464511_5 | We show that the three-protein regulatory circuit governing the decision is modular, as initiation and maintenance of chaining are genetically separable functions. | Memory and Modularity in Cell-Fate Decision Making |
464511_6 | As stimulation of the same initiating pathway triggers biofilm formation, we argue that autonomous timing allows a trial commitment to multicellularity that external signals could extend. | Memory and Modularity in Cell-Fate Decision Making |
791050_0 | OBJECTIVE To determine whether higher past exposure to particulate air pollution is associated with prevalent high symptoms of anxiety.
| The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_1 | DESIGN Observational cohort study.
| The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_2 | SETTING Nurses' Health Study.
| The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_3 | PARTICIPANTS 71,271 women enrolled in the Nurses' Health Study residing throughout the contiguous United States who had valid estimates on exposure to particulate matter for at least one exposure period of interest and data on anxiety symptoms.
| The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_4 | MAIN OUTCOME MEASURES Meaningfully high symptoms of anxiety, defined as a score of 6 points or greater on the phobic anxiety subscale of the Crown-Crisp index, administered in 2004.
| The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_5 | RESULTS The 71,271 eligible women were aged between 57 and 85 years (mean 70 years) at the time of assessment of anxiety symptoms, with a prevalence of high anxiety symptoms of 15%. | The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_6 | Exposure to particulate matter was characterized using estimated average exposure to particulate matter <2.5 μm in diameter (PM2.5) and 2.5 to 10 μm in diameter (PM2.5-10) in the one month, three months, six months, one year, and 15 years prior to assessment of anxiety symptoms, and residential distance to the nearest ... | The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_7 | Significantly increased odds of high anxiety symptoms were observed with higher exposure to PM2.5 for multiple averaging periods (for example, odds ratio per 10 µg/m(3) increase in prior one month average PM2.5: 1.12, 95% confidence interval 1.06 to 1.19; in prior 12 month average PM2.5: 1.15, 1.06 to 1.26). | The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_8 | Models including multiple exposure windows suggested short term averaging periods were more relevant than long term averaging periods. | The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_9 | There was no association between anxiety and exposure to PM2.5-10. | The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_10 | Residential proximity to major roads was not related to anxiety symptoms in a dose dependent manner.
| The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_11 | CONCLUSIONS Exposure to fine particulate matter (PM2.5) was associated with high symptoms of anxiety, with more recent exposures potentially more relevant than more distant exposures. | The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
791050_12 | Research evaluating whether reductions in exposure to ambient PM2.5 would reduce the population level burden of clinically relevant symptoms of anxiety is warranted. | The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study |
1084345_0 | Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the cellular quality-control systems. | Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function |
1084345_1 | We have previously found that CMA activity declines in aged organisms and have proposed that this failure in cellular clearance could contribute to the accumulation of altered proteins, the abnormal cellular homeostasis and, eventually, the functional loss characteristic of aged organisms. | Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function |
1084345_2 | To determine whether these negative features of aging can be prevented by maintaining efficient autophagic activity until late in life, in this work we have corrected the CMA defect in aged rodents. | Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function |
1084345_3 | We have generated a double transgenic mouse model in which the amount of the lysosomal receptor for CMA, previously shown to decrease in abundance with age, can be modulated. | Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function |
1084345_4 | We have analyzed in this model the consequences of preventing the age-dependent decrease in receptor abundance in aged rodents at the cellular and organ levels. | Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function |
1084345_5 | We show here that CMA activity is maintained until advanced ages if the decrease in the receptor abundance is prevented and that preservation of autophagic activity is associated with lower intracellular accumulation of damaged proteins, better ability to handle protein damage and improved organ function. | Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function |
1122279_0 | BACKGROUND Endothelium-dependent modulation of coronary tone is impaired in the collateral-dependent coronary microcirculation. | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1122279_1 | We used a porcine model of chronic coronary occlusion and collateral development to evaluate the hypothesis that exercise training enhances endothelium-mediated relaxation and increases endothelial nitric oxide synthase (ecNOS) mRNA levels of collateral-dependent microvasculature.
| Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1122279_2 | METHODS AND RESULTS Adult female miniature swine were subjected to chronic, progressive ameroid occlusion of the proximal left circumflex coronary artery (LCx); after 2 months, animals were randomly exposed to 16-week exercise-training (EX group; treadmill running) or sedentary (SED group; cage confinement) protocols. | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1122279_3 | After completion of EX or SED programs, coronary arterioles ( approximately 100 microm in diameter) were isolated from collateral-dependent LCx (distal to occlusion) and nonoccluded left anterior descending coronary artery (LAD) regions of each heart. | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1122279_4 | Arterioles were studied by in vitro videomicroscopy or frozen for ecNOS mRNA analysis (RT-PCR techniques). | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1122279_5 | Relaxation to the endothelium-dependent vasodilator bradykinin was decreased (P<0.05) in arterioles isolated from collateral-dependent LCx versus nonoccluded LAD regions of SED animals. | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1122279_6 | Bradykinin-mediated relaxation, however, was not different in LCx versus LAD arterioles isolated from EX animals. | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1122279_7 | Nitroprusside-induced relaxation was unaffected by either chronic occlusion or exercise. | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1122279_8 | Importantly, ecNOS mRNA expression was significantly decreased in arterioles isolated from LCx versus LAD regions of SED animals. | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1122279_9 | After training, ecNOS mRNA expression was not different between LAD and LCx arterioles.
| Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1122279_10 | CONCLUSIONS These data indicate that exercise training enhances bradykinin-mediated relaxation of collateral-dependent LCx arterioles isolated after chronic coronary occlusion, most likely because of effects on ecNOS mRNA expression and increased production of NO. | Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training. |
1180972_0 | An adoption study of genetic effects on obesity in adulthood was carried out in which adoptees separated from their natural parents very early in life were compared with their biological full and half siblings reared by their natural parents. | Genetics of obesity in adult adoptees and their biological siblings. |
1180972_1 | The adoptees represented four groups who by sampling from a larger population were categorised as either thin, medium weight, overweight, or obese. | Genetics of obesity in adult adoptees and their biological siblings. |
1180972_2 | Weight and height were obtained for 115 full siblings of 57 adoptees and for 850 half siblings of 341 adoptees. | Genetics of obesity in adult adoptees and their biological siblings. |
1180972_3 | In full siblings body mass index (kg/m2) significantly increased with weight of the adoptees. | Genetics of obesity in adult adoptees and their biological siblings. |
1180972_4 | Body mass index of the half siblings showed a steady but weaker increase across the four weight groups of adoptees. | Genetics of obesity in adult adoptees and their biological siblings. |
1180972_5 | There were no significant interactions with sex of the adoptees, sex of the siblings, or (for the half siblings) sex of the common parent. | Genetics of obesity in adult adoptees and their biological siblings. |
1180972_6 | In contrast with the findings in half siblings and (previously) the natural parents there was a striking, significant increase in body mass index between full siblings of overweight and obese adoptees. | Genetics of obesity in adult adoptees and their biological siblings. |
1180972_7 | The degree of fatness in adults living in the same environment appears to be influenced by genetic factors independent of sex, which may include polygenic as well as major gene effects on obesity. | Genetics of obesity in adult adoptees and their biological siblings. |
1469751_0 | Currently, major concerns about the safety and efficacy of RNA interference (RNAi)-based bone anabolic strategies still exist because of the lack of direct osteoblast-specific delivery systems for osteogenic siRNAs. | Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy |
1469751_1 | Here we screened the aptamer CH6 by cell-SELEX, specifically targeting both rat and human osteoblasts, and then we developed CH6 aptamer–functionalized lipid nanoparticles (LNPs) encapsulating osteogenic pleckstrin homology domain-containing family O member 1 (Plekho1) siRNA (CH6-LNPs-siRNA). | Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy |
1469751_2 | Our results showed that CH6 facilitated in vitro osteoblast-selective uptake of Plekho1 siRNA, mainly via macropinocytosis, and boosted in vivo osteoblast-specific Plekho1 gene silencing, which promoted bone formation, improved bone microarchitecture, increased bone mass and enhanced mechanical properties in both osteo... | Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy |
1469751_3 | These results indicate that osteoblast-specific aptamer-functionalized LNPs could act as a new RNAi-based bone anabolic strategy, advancing the targeted delivery selectivity of osteogenic siRNAs from the tissue level to the cellular level. | Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy |
1568684_0 | The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. |
1568684_1 | In rodents, BAT can be activated by bile acids, which activate type 2 iodothyronine deiodinase (D2) in BAT via the G-coupled protein receptor TGR5, resulting in increased oxygen consumption and energy expenditure. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. |
1568684_2 | Here we examined the effects of oral supplementation of the bile acid chenodeoxycholic acid (CDCA) on human BAT activity. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. |
1568684_3 | Treatment of 12 healthy female subjects with CDCA for 2 days resulted in increased BAT activity. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. |
1568684_4 | Whole-body energy expenditure was also increased upon CDCA treatment. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. |
1568684_5 | In vitro treatment of primary human brown adipocytes derived with CDCA or specific TGR5 agonists increased mitochondrial uncoupling and D2 expression, an effect that was absent in human primary white adipocytes. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. |
1568684_6 | These findings identify bile acids as a target to activate BAT in humans. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. |
1642727_0 | CONTEXT Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking.
| Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_1 | OBJECTIVE To determine whether physical activity reduces the rate of cognitive decline among older adults at risk.
| Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_2 | DESIGN AND SETTING Randomized controlled trial of a 24-week physical activity intervention conducted between 2004 and 2007 in metropolitan Perth, Western Australia. | Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_3 | Assessors of cognitive function were blinded to group membership.
| Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_4 | PARTICIPANTS We recruited volunteers who reported memory problems but did not meet criteria for dementia. | Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_5 | Three hundred eleven individuals aged 50 years or older were screened for eligibility, 89 were not eligible, and 52 refused to participate. | Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_6 | A total of 170 participants were randomized and 138 participants completed the 18-month assessment.
| Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_7 | INTERVENTION Participants were randomly allocated to an education and usual care group or to a 24-week home-based program of physical activity.
| Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_8 | MAIN OUTCOME MEASURE Change in Alzheimer Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) scores (possible range, 0-70) over 18 months.
| Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_9 | RESULTS In an intent-to-treat analysis, participants in the intervention group improved 0.26 points (95% confidence interval, -0.89 to 0.54) and those in the usual care group deteriorated 1.04 points (95% confidence interval, 0.32 to 1.82) on the ADAS-Cog at the end of the intervention. | Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_10 | The absolute difference of the outcome measure between the intervention and control groups was -1.3 points (95% confidence interval,-2.38 to -0.22) at the end of the intervention. | Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_11 | At 18 months, participants in the intervention group improved 0.73 points (95% confidence interval, -1.27 to 0.03) on the ADAS-Cog, and those in the usual care group improved 0.04 points (95% confidence interval, -0.46 to 0.88). | Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_12 | Word list delayed recall and Clinical Dementia Rating sum of boxes improved modestly as well, whereas word list total immediate recall, digit symbol coding, verbal fluency, Beck depression score, and Medical Outcomes 36-Item Short-Form physical and mental component summaries did not change significantly.
| Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_13 | CONCLUSIONS In this study of adults with subjective memory impairment, a 6-month program of physical activity provided a modest improvement in cognition over an 18-month follow-up period.
| Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1642727_14 | TRIAL REGISTRATION anzctr.org.au Identifier: ACTRN12605000136606. | Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. |
1805641_0 | BACKGROUND Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and have the potential to reduce population-level transmission of the parasite. | Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity |
1805641_1 | With the increased interest in malaria elimination, understanding the impact on transmission of ACT and other antimalarial drugs with different pharmacodynamics becomes a key issue. | Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity |
1805641_2 | This study estimates the reduction in transmission that may be achieved by introducing different types of treatment for symptomatic P. falciparum malaria in endemic areas.
| Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity |
1805641_3 | METHODS AND FINDINGS We developed a mathematical model to predict the potential impact on transmission outcomes of introducing ACT as first-line treatment for uncomplicated malaria in six areas of varying transmission intensity in Tanzania. | Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity |
1805641_4 | We also estimated the impact that could be achieved by antimalarials with different efficacy, prophylactic time, and gametocytocidal effects. | Modelling the Impact of Artemisinin Combination Therapy and Long-Acting Treatments on Malaria Transmission Intensity |
LMEB semantic retrieval task based on SciFact, retrieving scientific evidence passages for claim verification.
| Task category | Retrieval (text-to-text) |
| Domains | Academic, Written |
| Reference | LMEB: Long-horizon Memory Embedding Benchmark |
Source datasets:
You can evaluate an embedding model on this dataset using the following code:
import mteb
task = mteb.get_task("LMEB_SciFact")
model = mteb.get_model(YOUR_MODEL)
mteb.evaluate(model, task)
To learn more about how to run models on mteb task check out the GitHub repository.
If you use this dataset, please cite the dataset as well as mteb, as this dataset likely includes additional processing as a part of the MMTEB Contribution.
@misc{zhao2026lmeb,
archiveprefix = {arXiv},
author = {Zhao, Xinping and Hu, Xinshuo and Xu, Jiaxin and Tang, Danyu and Zhang, Xin and Zhou, Mengjia and Zhong, Yan and Zhou, Yao and Shan, Zifei and Zhang, Meishan and Hu, Baotian and Zhang, Min},
eprint = {2603.12572},
primaryclass = {cs.CL},
title = {LMEB: Long-horizon Memory Embedding Benchmark},
url = {https://arxiv.org/abs/2603.12572},
year = {2026},
}
@article{enevoldsen2025mmtebmassivemultilingualtext,
title={MMTEB: Massive Multilingual Text Embedding Benchmark},
author={Kenneth Enevoldsen and Isaac Chung and Imene Kerboua and Márton Kardos and Ashwin Mathur and David Stap and Jay Gala and Wissam Siblini and Dominik Krzemiński and Genta Indra Winata and Saba Sturua and Saiteja Utpala and Mathieu Ciancone and Marion Schaeffer and Gabriel Sequeira and Diganta Misra and Shreeya Dhakal and Jonathan Rystrøm and Roman Solomatin and Ömer Çağatan and Akash Kundu and Martin Bernstorff and Shitao Xiao and Akshita Sukhlecha and Bhavish Pahwa and Rafał Poświata and Kranthi Kiran GV and Shawon Ashraf and Daniel Auras and Björn Plüster and Jan Philipp Harries and Loïc Magne and Isabelle Mohr and Mariya Hendriksen and Dawei Zhu and Hippolyte Gisserot-Boukhlef and Tom Aarsen and Jan Kostkan and Konrad Wojtasik and Taemin Lee and Marek Šuppa and Crystina Zhang and Roberta Rocca and Mohammed Hamdy and Andrianos Michail and John Yang and Manuel Faysse and Aleksei Vatolin and Nandan Thakur and Manan Dey and Dipam Vasani and Pranjal Chitale and Simone Tedeschi and Nguyen Tai and Artem Snegirev and Michael Günther and Mengzhou Xia and Weijia Shi and Xing Han Lù and Jordan Clive and Gayatri Krishnakumar and Anna Maksimova and Silvan Wehrli and Maria Tikhonova and Henil Panchal and Aleksandr Abramov and Malte Ostendorff and Zheng Liu and Simon Clematide and Lester James Miranda and Alena Fenogenova and Guangyu Song and Ruqiya Bin Safi and Wen-Ding Li and Alessia Borghini and Federico Cassano and Hongjin Su and Jimmy Lin and Howard Yen and Lasse Hansen and Sara Hooker and Chenghao Xiao and Vaibhav Adlakha and Orion Weller and Siva Reddy and Niklas Muennighoff},
publisher = {arXiv},
journal={arXiv preprint arXiv:2502.13595},
year={2025},
url={https://arxiv.org/abs/2502.13595},
doi = {10.48550/arXiv.2502.13595},
}
@article{muennighoff2022mteb,
author = {Muennighoff, Niklas and Tazi, Nouamane and Magne, Loïc and Reimers, Nils},
title = {MTEB: Massive Text Embedding Benchmark},
publisher = {arXiv},
journal={arXiv preprint arXiv:2210.07316},
year = {2022}
url = {https://arxiv.org/abs/2210.07316},
doi = {10.48550/ARXIV.2210.07316},
}
The following code contains the descriptive statistics from the task. These can also be obtained using:
import mteb
task = mteb.get_task("LMEB_SciFact")
desc_stats = task.metadata.descriptive_stats
{
"test": {
"num_samples": 1936,
"number_of_characters": 490100,
"documents_text_statistics": {
"total_text_length": 473214,
"min_text_length": 52,
"average_text_length": 270.7173913043478,
"max_text_length": 1019,
"unique_texts": 1748
},
"documents_image_statistics": null,
"documents_audio_statistics": null,
"queries_text_statistics": {
"total_text_length": 16886,
"min_text_length": 37,
"average_text_length": 89.81914893617021,
"max_text_length": 204,
"unique_texts": 188
},
"queries_image_statistics": null,
"queries_audio_statistics": null,
"relevant_docs_statistics": {
"num_relevant_docs": 366,
"min_relevant_docs_per_query": 1,
"average_relevant_docs_per_query": 1.946808510638298,
"max_relevant_docs_per_query": 12,
"unique_relevant_docs": 327
},
"top_ranked_statistics": null,
"hf_subset_descriptive_stats": {
"LMEB_SciFact": {
"num_samples": 1936,
"number_of_characters": 490100,
"documents_text_statistics": {
"total_text_length": 473214,
"min_text_length": 52,
"average_text_length": 270.7173913043478,
"max_text_length": 1019,
"unique_texts": 1748
},
"documents_image_statistics": null,
"documents_audio_statistics": null,
"queries_text_statistics": {
"total_text_length": 16886,
"min_text_length": 37,
"average_text_length": 89.81914893617021,
"max_text_length": 204,
"unique_texts": 188
},
"queries_image_statistics": null,
"queries_audio_statistics": null,
"relevant_docs_statistics": {
"num_relevant_docs": 366,
"min_relevant_docs_per_query": 1,
"average_relevant_docs_per_query": 1.946808510638298,
"max_relevant_docs_per_query": 12,
"unique_relevant_docs": 327
},
"top_ranked_statistics": null
}
}
}
}
This dataset card was automatically generated using MTEB