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Multimodal multiscale analysis reveals flexible DNA contacts of bacterial nucleoprotein filaments
molecular biology
High rates of genome rearrangements and pathogenicity of Shigella spp.
bioinformatics
Unilateral and Bilateral Subthalamic stimulation differently promote apathy: a translational approach
neuroscience
Activity Dependent Stimulation Increases Synaptic Efficacy In Spared Pathways In An Anesthetized Rat Model Of Spinal Cord Contusion Injury
neuroscience
Energy deficit-independent stress response in the Frataxin-depleted heart: evidence that Integrated Stress Response can predominate over mTORC1 activation
biochemistry
scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks
bioinformatics
DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas (PanNECs) and pancreatic neuroendocrine tumors (PanNETs)
cancer biology
Co-occupancy analysis reveals novel transcriptional synergies for axon growth
neuroscience
State-dependent signatures of Anti-NMDA-Receptor Encephalitis: a dynamic functional connectivity study
neuroscience
High Content Screening and Proteomic Analysis Identify a Kinase Inhibitor that rescuespathological phenotypes in a Patient-Derived Model of Parkinson's Disease
neuroscience
Global FAW population genomic signature supports complex introduction events across the Old World
evolutionary biology
Room Temperature Isothermal Colorimetric Padlock Probe Rolling Circle Amplification for Viral RNA Detection
synthetic biology
Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza
biophysics
Temporal hierarchy of intrinsic neural timescales converges with spatial core-periphery organization
neuroscience
Ethylene-triggered subcellular trafficking of CTR1 enhances the response to ethylene gas
plant biology
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons
cell biology
Steady-State Regulation of Secretory Cargo Export by Inositol Trisphosphate Receptors and Penta-EF-Hand Proteins
cell biology
Visual processing and fold-change detection by the larva of the simple chordate Ciona
neuroscience
Quantifying Numerical and Spatial Reliability of Amygdala and Hippocampal Subdivisions in FreeSurfer
neuroscience
Self-fertilization, but not mating strategy, predicts the evolution of sex allocation plasticity in a hermaphroditic flatworm genus
evolutionary biology
MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis
cancer biology
A comprehensive framework for handling location error in animal tracking data
ecology
Predicting feral cat-reduction targets and costs on large islands using stochastic population models
ecology
LayNii: A software suite for layer-fMRI.
neuroscience
Deep multitask learning of gene risk for comorbid neurodevelopmental disorders
bioinformatics
Metal-Organic Framework Encapsulated Whole-Cell Vaccines Enhance Humoral Immunity against Bacterial Infection
immunology
Nuclear and cellular, micro and nano calcification in Alzheimer's disease patients and correlation to phosphorylated Tau.
pathology
Human Prefoldin Modulates Co-transcriptional Pre-mRNA Splicing
molecular biology
Dissecting Response to Cancer Immunotherapy by Applying Bayesian Network Analysis to Flow Cytometry Data
systems biology
Robustness in spiking networks: a geometric perspective
neuroscience
Collective motion as a distinct behavioral state of the individual
ecology
Diet-regulated production of PDGFcc by macrophages controls energy storage
immunology
Prediction of amphipathic helix - membrane interactions with Rosetta
biophysics
A learned map for places and concepts in the human MTL
neuroscience
Improving oligo-conjugated antibody signal in multimodal single-cell analysis
genomics
Integrated analysis of glycan and RNA in single cells
genomics
Beyond category-supervision: instance-level contrastive learning models predict human visual system responses to objects
neuroscience
Segmentation-less, automated vascular vectorization robustly extracts neurovascular network statistics from in vivo two-photon images
bioengineering
Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations
neuroscience
Enhancing Mask Activity in Dopaminergic Neurons Extends Lifespan in Flies
neuroscience
Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments
cell biology
Wnt-and Glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division
cell biology
Population genomic time series data of a natural population suggests adaptive tracking of environmental changes
evolutionary biology
Targeted control of toxin production by a mobile genetic element in Streptococcus pneumoniae.
microbiology
Polygenic local adaptation in metapopulations: a stochastic eco-evolutionary model
evolutionary biology
Diagnostic Evidence GAuge of Single cells (DEGAS): A flexible deep-transfer learning framework for prioritizing cells in relation to disease
bioinformatics
Transcriptogram analysis reveals relationship between viral titer and gene set responses during Corona-virus infection.
bioinformatics
Rostrocaudal Patterning and Neural Crest Differentiation of Human Pre-Neural Spinal Cord Progenitors in vitro
developmental biology
Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis
cell biology
Hippocampus-lateral septum circuitry mediates foraging-related spatial memory
neuroscience
Dissociation of task engagement and arousal effects in auditory cortex and midbrain
neuroscience
Syntactic representations in the human brain: beyond effort-based metrics
neuroscience
Quantitative mapping of mRNA 3' ends in Pseudomonas aeruginosa reveals a pervasive role for premature 3' end formation in response to azithromycin
microbiology
Continuum dynamics and statistical correction of compositional heterogeneity in multivalent IDP oligomers resolved by single-particle EM
biophysics
Disruption of the gut microbiota attenuates epithelial ovarian cancer sensitivity to cisplatin therapy
cancer biology
A physicochemical model of odor sampling
neuroscience
The relationship between EEG and fMRI connectomes is reproducible across simultaneous EEG-fMRI studies from 1.5T to 7T
neuroscience
Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions.
neuroscience
A COVID Moonshot: assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy.
biochemistry
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
systems biology
Characterisation of the role and regulation of Ultrabithorax in sculpting fine-scale leg morphology
developmental biology
Single cell transcriptomic profiling identifies molecular phenotypes of newborn human lung cells
genomics
Gut microbial taxa elevated by dietary sugar disrupt memory function
neuroscience
Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus
evolutionary biology
Representation Learning of Resting State fMRI with Variational Autoencoder
neuroscience
Modulation of inhibitory communication coordinates looking and reaching
neuroscience
Optimisation of functional network resources when learning behavioural strategies for performing complex tasks
neuroscience
Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs
biophysics
ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer
bioinformatics
Analysis of overlapping genetic association in type 1 and type 2 diabetes
genetics
A multi-enhancer RET regulatory code is disrupted in Hirschsprung disease
genomics
Computational Model of G2-M DNA Damage Checkpoint Regulation in Normal and p53-null Cancer Cells
systems biology
3D-printed drug testing platform based on a 3D model of aged human skeletal muscle
bioengineering
The validation of new phase-dependent gait stability measures: a modelling approach
bioengineering
The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma
cancer biology
Virulence strategies of an insect herbivore and oomycete plant pathogen converge on a host E3 SUMO ligase
plant biology
Patterns of recent natural selection on genetic loci associated with sexually differentiated human body size and shape phenotypes
evolutionary biology
Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243A>G mtDNA mutation
cell biology
Temporal dynamics of the neural representation of hue and luminance contrast
neuroscience
Neuronal variability reflects probabilistic inference tuned to natural image statistics
neuroscience
Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity
neuroscience
Outdoor Atmospheric Microbial Diversity is Associated with Urban Landscape Structure and Differs from Indoor-Transit Systems as Revealed by Mobile Monitoring and Three-Dimensional Spatial Analysis
ecology
Coupled Dynamics of Behavior and Disease Contagion Among Antagonistic Groups
ecology
Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction.
microbiology
Disruption of the MreB elongasome is overcome by mutations in the TCA cycle
microbiology
Modelling the effects of lymph node swelling on T-cell response
immunology
Sailing in rough waters: examining volatility of fMRI noise
neuroscience
A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program
genetics
Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo
molecular biology
Brainprints: identifying individuals from magnetoencephalograms
neuroscience
Can expectation suppression be explained by reduced attention to predictable stimuli?
neuroscience
GenNet framework: interpretable neural networks for phenotype prediction
bioinformatics
Dengue virus clinical isolates sustain viability of infected hepatic cells by counteracting apoptosis-mediated DNA breakage
microbiology
Sequence structure context organizes items in varied latent states of working memory neural network
neuroscience
Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hotspots, Functional Crosstalk and Regulatory Interactions in SARS-CoV-2
microbiology
Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells
immunology
Preference for animate domain sounds in the fusiform gyrus of blind individuals is modulated by shape-action mapping
neuroscience
Simultaneously monitoring aquatic and riparian biodiversity using riverine water eDNA
ecology
Low competitive status elicits aggression in healthy young men: behavioral and neural evidence
neuroscience
Lift observation conveys object weight distribution but partly enhances predictive lift planning
neuroscience