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Multimodal multiscale analysis reveals flexible DNA contacts of bacterial nucleoprotein filaments
|
molecular biology
|
High rates of genome rearrangements and pathogenicity of Shigella spp.
|
bioinformatics
|
Unilateral and Bilateral Subthalamic stimulation differently promote apathy: a translational approach
|
neuroscience
|
Activity Dependent Stimulation Increases Synaptic Efficacy In Spared Pathways In An Anesthetized Rat Model Of Spinal Cord Contusion Injury
|
neuroscience
|
Energy deficit-independent stress response in the Frataxin-depleted heart: evidence that Integrated Stress Response can predominate over mTORC1 activation
|
biochemistry
|
scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks
|
bioinformatics
|
DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas (PanNECs) and pancreatic neuroendocrine tumors (PanNETs)
|
cancer biology
|
Co-occupancy analysis reveals novel transcriptional synergies for axon growth
|
neuroscience
|
State-dependent signatures of Anti-NMDA-Receptor Encephalitis: a dynamic functional connectivity study
|
neuroscience
|
High Content Screening and Proteomic Analysis Identify a Kinase Inhibitor that rescuespathological phenotypes in a Patient-Derived Model of Parkinson's Disease
|
neuroscience
|
Global FAW population genomic signature supports complex introduction events across the Old World
|
evolutionary biology
|
Room Temperature Isothermal Colorimetric Padlock Probe Rolling Circle Amplification for Viral RNA Detection
|
synthetic biology
|
Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza
|
biophysics
|
Temporal hierarchy of intrinsic neural timescales converges with spatial core-periphery organization
|
neuroscience
|
Ethylene-triggered subcellular trafficking of CTR1 enhances the response to ethylene gas
|
plant biology
|
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons
|
cell biology
|
Steady-State Regulation of Secretory Cargo Export by Inositol Trisphosphate Receptors and Penta-EF-Hand Proteins
|
cell biology
|
Visual processing and fold-change detection by the larva of the simple chordate Ciona
|
neuroscience
|
Quantifying Numerical and Spatial Reliability of Amygdala and Hippocampal Subdivisions in FreeSurfer
|
neuroscience
|
Self-fertilization, but not mating strategy, predicts the evolution of sex allocation plasticity in a hermaphroditic flatworm genus
|
evolutionary biology
|
MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis
|
cancer biology
|
A comprehensive framework for handling location error in animal tracking data
|
ecology
|
Predicting feral cat-reduction targets and costs on large islands using stochastic population models
|
ecology
|
LayNii: A software suite for layer-fMRI.
|
neuroscience
|
Deep multitask learning of gene risk for comorbid neurodevelopmental disorders
|
bioinformatics
|
Metal-Organic Framework Encapsulated Whole-Cell Vaccines Enhance Humoral Immunity against Bacterial Infection
|
immunology
|
Nuclear and cellular, micro and nano calcification in Alzheimer's disease patients and correlation to phosphorylated Tau.
|
pathology
|
Human Prefoldin Modulates Co-transcriptional Pre-mRNA Splicing
|
molecular biology
|
Dissecting Response to Cancer Immunotherapy by Applying Bayesian Network Analysis to Flow Cytometry Data
|
systems biology
|
Robustness in spiking networks: a geometric perspective
|
neuroscience
|
Collective motion as a distinct behavioral state of the individual
|
ecology
|
Diet-regulated production of PDGFcc by macrophages controls energy storage
|
immunology
|
Prediction of amphipathic helix - membrane interactions with Rosetta
|
biophysics
|
A learned map for places and concepts in the human MTL
|
neuroscience
|
Improving oligo-conjugated antibody signal in multimodal single-cell analysis
|
genomics
|
Integrated analysis of glycan and RNA in single cells
|
genomics
|
Beyond category-supervision: instance-level contrastive learning models predict human visual system responses to objects
|
neuroscience
|
Segmentation-less, automated vascular vectorization robustly extracts neurovascular network statistics from in vivo two-photon images
|
bioengineering
|
Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations
|
neuroscience
|
Enhancing Mask Activity in Dopaminergic Neurons Extends Lifespan in Flies
|
neuroscience
|
Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments
|
cell biology
|
Wnt-and Glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division
|
cell biology
|
Population genomic time series data of a natural population suggests adaptive tracking of environmental changes
|
evolutionary biology
|
Targeted control of toxin production by a mobile genetic element in Streptococcus pneumoniae.
|
microbiology
|
Polygenic local adaptation in metapopulations: a stochastic eco-evolutionary model
|
evolutionary biology
|
Diagnostic Evidence GAuge of Single cells (DEGAS): A flexible deep-transfer learning framework for prioritizing cells in relation to disease
|
bioinformatics
|
Transcriptogram analysis reveals relationship between viral titer and gene set responses during Corona-virus infection.
|
bioinformatics
|
Rostrocaudal Patterning and Neural Crest Differentiation of Human Pre-Neural Spinal Cord Progenitors in vitro
|
developmental biology
|
Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis
|
cell biology
|
Hippocampus-lateral septum circuitry mediates foraging-related spatial memory
|
neuroscience
|
Dissociation of task engagement and arousal effects in auditory cortex and midbrain
|
neuroscience
|
Syntactic representations in the human brain: beyond effort-based metrics
|
neuroscience
|
Quantitative mapping of mRNA 3' ends in Pseudomonas aeruginosa reveals a pervasive role for premature 3' end formation in response to azithromycin
|
microbiology
|
Continuum dynamics and statistical correction of compositional heterogeneity in multivalent IDP oligomers resolved by single-particle EM
|
biophysics
|
Disruption of the gut microbiota attenuates epithelial ovarian cancer sensitivity to cisplatin therapy
|
cancer biology
|
A physicochemical model of odor sampling
|
neuroscience
|
The relationship between EEG and fMRI connectomes is reproducible across simultaneous EEG-fMRI studies from 1.5T to 7T
|
neuroscience
|
Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions.
|
neuroscience
|
A COVID Moonshot: assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy.
|
biochemistry
|
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
|
systems biology
|
Characterisation of the role and regulation of Ultrabithorax in sculpting fine-scale leg morphology
|
developmental biology
|
Single cell transcriptomic profiling identifies molecular phenotypes of newborn human lung cells
|
genomics
|
Gut microbial taxa elevated by dietary sugar disrupt memory function
|
neuroscience
|
Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus
|
evolutionary biology
|
Representation Learning of Resting State fMRI with Variational Autoencoder
|
neuroscience
|
Modulation of inhibitory communication coordinates looking and reaching
|
neuroscience
|
Optimisation of functional network resources when learning behavioural strategies for performing complex tasks
|
neuroscience
|
Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs
|
biophysics
|
ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer
|
bioinformatics
|
Analysis of overlapping genetic association in type 1 and type 2 diabetes
|
genetics
|
A multi-enhancer RET regulatory code is disrupted in Hirschsprung disease
|
genomics
|
Computational Model of G2-M DNA Damage Checkpoint Regulation in Normal and p53-null Cancer Cells
|
systems biology
|
3D-printed drug testing platform based on a 3D model of aged human skeletal muscle
|
bioengineering
|
The validation of new phase-dependent gait stability measures: a modelling approach
|
bioengineering
|
The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma
|
cancer biology
|
Virulence strategies of an insect herbivore and oomycete plant pathogen converge on a host E3 SUMO ligase
|
plant biology
|
Patterns of recent natural selection on genetic loci associated with sexually differentiated human body size and shape phenotypes
|
evolutionary biology
|
Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243A>G mtDNA mutation
|
cell biology
|
Temporal dynamics of the neural representation of hue and luminance contrast
|
neuroscience
|
Neuronal variability reflects probabilistic inference tuned to natural image statistics
|
neuroscience
|
Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity
|
neuroscience
|
Outdoor Atmospheric Microbial Diversity is Associated with Urban Landscape Structure and Differs from Indoor-Transit Systems as Revealed by Mobile Monitoring and Three-Dimensional Spatial Analysis
|
ecology
|
Coupled Dynamics of Behavior and Disease Contagion Among Antagonistic Groups
|
ecology
|
Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction.
|
microbiology
|
Disruption of the MreB elongasome is overcome by mutations in the TCA cycle
|
microbiology
|
Modelling the effects of lymph node swelling on T-cell response
|
immunology
|
Sailing in rough waters: examining volatility of fMRI noise
|
neuroscience
|
A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program
|
genetics
|
Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo
|
molecular biology
|
Brainprints: identifying individuals from magnetoencephalograms
|
neuroscience
|
Can expectation suppression be explained by reduced attention to predictable stimuli?
|
neuroscience
|
GenNet framework: interpretable neural networks for phenotype prediction
|
bioinformatics
|
Dengue virus clinical isolates sustain viability of infected hepatic cells by counteracting apoptosis-mediated DNA breakage
|
microbiology
|
Sequence structure context organizes items in varied latent states of working memory neural network
|
neuroscience
|
Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hotspots, Functional Crosstalk and Regulatory Interactions in SARS-CoV-2
|
microbiology
|
Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells
|
immunology
|
Preference for animate domain sounds in the fusiform gyrus of blind individuals is modulated by shape-action mapping
|
neuroscience
|
Simultaneously monitoring aquatic and riparian biodiversity using riverine water eDNA
|
ecology
|
Low competitive status elicits aggression in healthy young men: behavioral and neural evidence
|
neuroscience
|
Lift observation conveys object weight distribution but partly enhances predictive lift planning
|
neuroscience
|
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