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Unexpected proteinopathies in hippocampal PDE11A4 promote age-related cognitive decline of social associative memories
|
neuroscience
|
HiFENS: High-throughput FISH detection of endogenous pre-mRNA splicing isoforms
|
cell biology
|
multiplestressR: An R package to analyse factorial multiple stressor data using the additive and multiplicative null models
|
ecology
|
Periodic Environmental Disturbance Drives Repeated Ecomorphological Diversification in an Adaptive Radiation of Antarctic Fishes
|
evolutionary biology
|
MPI region of interest (ROI) analysis and quantification of iron in different volumes
|
biophysics
|
Microbial Community Dynamics of a Sequentially Fed Anaerobic Digester Treating Solid Organic Waste
|
bioengineering
|
A chemomechanical model of sperm locomotion reveals two modes of swimming
|
biophysics
|
An interplay between JA and SA modulates rapid systemic ROS signaling during responses to high light stress or wounding
|
plant biology
|
Visual Mode Switching: Improved General Compensation to Environmental Color Change Requires Only One Exposure Per Day
|
neuroscience
|
Synaptic vesicle-bound molecular bridges organize sequential vesicle states along parallel pathways
|
neuroscience
|
The effect of different treatment durations with indole-3-acetic acid (IAA)-producing endophytic Bacillus spp. on tomato 'Aicha' under saline conditions
|
microbiology
|
Puf3p facilitates fermentative mitochondrial functions via monosome-enriched nuclear-encoded mitochondrial mRNAs in budding yeast
|
molecular biology
|
In situ single particle classification reveals distinct 60S maturation intermediates in cells
|
biophysics
|
Learning-related contraction of grey matter in rodent sensorimotor cortex is associated with adaptive myelination
|
neuroscience
|
Larger and more dentated hippocampal structure is associated with better memory in the oldest-old.
|
neuroscience
|
Contrasting effects of reduced phosphatidylcholine synthesis in absence of seipin: embryonic lethality goes down while lipid droplets get even larger
|
developmental biology
|
Whole-genome duplication in an algal symbiont serendipitously confers thermal tolerance to corals
|
genomics
|
wenda_gpu: fast domain adaptation for genomic data
|
bioinformatics
|
First crystal structure of a non-canonical amino acid linked to a paramagnetic lanthanide tag facilitates protein structure determination using NMR-derived restraints
|
biophysics
|
A cross-sectional study of the commercial plant-based landscape across the US, UK and Canada.
|
scientific communication and education
|
Efficient evolution of human antibodies from general protein language models and sequence information alone
|
synthetic biology
|
The Interplay of Attention and Conscious Perception: Evidence from Human Intracerebral Recordings and Computational Modeling
|
neuroscience
|
Sleep Disruption Selectively Weakens Reactivated Memories
|
neuroscience
|
CAPG is required for Ebola virus infection by controlling virus egress from infected cells.
|
microbiology
|
Symbiosis between Patescibacteria and Archaea discovered in wastewater-treating bioreactors
|
microbiology
|
DeepPerVar: a multimodal deep learning framework for functional interpretation of genetic variants in personal genome
|
bioinformatics
|
From Specification to Implementation: Assume-Guarantee Contracts for Synthetic Biology
|
synthetic biology
|
Core and accessory effectors of type VI secretion systems contribute differently to the intraspecific diversity of Pseudomonas aeruginosa
|
microbiology
|
Identification of a novel AP2 transcription factor in zygotes with an essential role in Plasmodium ookinete development.
|
microbiology
|
Plant protection habits among Hungarian farmers and garden owners and their implications for pollinator protection
|
ecology
|
Using large soybean historical data to study genotype by environment variation and identify mega-environments with the integration of genetic and non-genetic factors
|
genetics
|
Privacy-Preserving Statistical Analysis of Genomic Data using Compressive Mechanism with Haar Wavelet Transform
|
genomics
|
The conserved centrosomal motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC).
|
biochemistry
|
Tomographic-encoded multiphoton (TEMP) microscopy
|
bioengineering
|
ReDisX: a Continuous Max Flow-based framework to redefine the diagnosis of diseases based on identified patterns of genomic signatures
|
bioinformatics
|
Single-cell colocalization analysis using a deep generative model
|
bioinformatics
|
Short-course but not prolonged treatment with ATR inhibitor AZD6738 integrates with radiotherapy to generate a tumor antigen-specific CD8+ T cell expansion in the periphery
|
cancer biology
|
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability in cancer
|
cancer biology
|
Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis
|
physiology
|
Linker histone H1 regulates defense priming and immunity in plants
|
plant biology
|
Genome-scale metabolic modelling enables deciphering ethanol metabolism via the acrylate pathway in the propionate-producer Anaerotignum neopropionicum
|
systems biology
|
Variation in subcortical anatomy: relating interspecies differences, heritability, and brain-behavior relationships
|
neuroscience
|
Overcoming the Reproducibility Crisis - Results of the first Community Survey of the German National Research Data Infrastructure for Neuroscience.
|
neuroscience
|
Brainstem speech encoding is dynamically shaped online by fluctuations in cortical α state
|
neuroscience
|
Endogenous viral elements reveal associations between a non-retroviral RNA virus and symbiotic dinoflagellate genomes
|
microbiology
|
Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target
|
cell biology
|
METTL3 regulates breast cancer-associated alternative splicing switches
|
cell biology
|
Novel frontier in wildlife monitoring: identification of small rodent species from faecal pellets using Near-Infrared Reflectance Spectroscopy (NIRS)
|
ecology
|
Isolation and Divergence of Peromyscus melanotis Populations Across the Madrean Sky Islands in Arizona
|
evolutionary biology
|
Protein engineering approach to enhance activity assays of mono-ADP-ribosyltransferases through proximity
|
biochemistry
|
Phylogenetic-informed graph deep learning to classify dynamic transmission clusters in infectious disease epidemics
|
bioinformatics
|
A maximum mean discrepancy approach reveals subtle changes in α-synuclein dynamics
|
biophysics
|
Between-area communication through the lens of within-area neuronal dynamics
|
neuroscience
|
Expansive Linguistic Representations to Predict Interpretable Odor Mixture Discriminability
|
neuroscience
|
A Neurodynamic Model of Inter-Brain Coupling in the Gamma Band
|
neuroscience
|
Neural mass modelling for the masses: Democratising access to whole-brain biophysical modelling with FastDMF
|
neuroscience
|
Neuronal activity regulates Matrin 3 levels and function in a calcium-dependent manner through calpain cleavage and calmodulin binding
|
neuroscience
|
Every individual makes a difference: A trinity derived from linking individual brain morphometry, connectivity and mentalising ability
|
neuroscience
|
Condensation of LINE-1 is required for retrotransposition
|
cell biology
|
Positive fitness effects help explain the broad range of Wolbachia prevalences in natural populations
|
ecology
|
Independent acquisition of short insertions at the RIR1 site in the spike N-terminal domain of the SARS-CoV-2 BA.2 lineage
|
genomics
|
Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-associated Excitable Cells
|
bioengineering
|
Subtyping of major SARS-CoV-2 variants reveals different transmission dynamics
|
bioinformatics
|
Candidate genes associated with neurological manifestations of COVID-19: Meta-analysis using multiple computational approaches
|
systems biology
|
Genotypic and phenotypic diversity of the multidrug-resistant Mycobacterium tuberculosis strains from eastern India
|
microbiology
|
Peptidoglycan maturation controls spatiotemporal organisation of outer membrane proteins in Escherichia coli
|
microbiology
|
RNA-protein interactome at the Hepatitis E virus internal ribosome entry site
|
microbiology
|
Toxoplasma scavenges mammalian host organelles through usurpation of host ESCRT-III and Vps4
|
microbiology
|
An electro-optical bead-nanochip technology for the ultrasensitive and multi-dimensional detection of small extracellular vesicles and their markers
|
molecular biology
|
Quantitation of FGFR3 signaling via GRB2 recruitment on micropatterned surfaces
|
molecular biology
|
Multi-level monitoring of EME1-MUS81 in CPT induced nucleolar rDNA repair
|
molecular biology
|
An adaptive filtering framework for non-specific and inefficient reactions in multiplex digital PCR based on sigmoidal trends
|
molecular biology
|
Separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis
|
cell biology
|
A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target
|
cell biology
|
Reduced affinity of calcium sensing-receptor heterodimers and reduced mutant homodimer trafficking combine to impair function in a mouse model of Familial Hypocalciuric Hypercalcemia Type 1
|
cell biology
|
Gradients in cellular metabolism regulate development of tonotopy along the chick cochlea.
|
developmental biology
|
Phylotranscriptomics Reveals the Reticulate Evolutionary History of a Widespread Diatom Species Complex
|
genomics
|
Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
|
genomics
|
An intrinsically disordered transcription activation domain alters the DNA binding affinity and specificity of NFκB p50/RelA
|
biochemistry
|
Rational design by structural biology of industrializable, long-acting antihyperglycemic GLP-1 receptor agonists
|
bioengineering
|
SARS-ANI: A Global Open Access Dataset of Reported SARS-CoV-2 Events in Animals
|
microbiology
|
Key mutations on spike protein altering ACE2 receptor utilization and potentially expanding host range of emerging SARS-CoV-2 variants
|
microbiology
|
UBC9 and EME1 sumoylation foster ribosomal DNA damage repair in CPT response
|
molecular biology
|
Disrupting ACE2 Dimerization Mitigates the Infection by SARS-COV-2
|
molecular biology
|
A synthetic ancestral Kinesin-13 depolymerises microtubules faster than any natural depolymerising kinesin
|
molecular biology
|
Autophagy Increases Occludin Levels to Enhance Intestinal Paracellular Tight Junction Barrier.
|
cell biology
|
Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist
|
cell biology
|
Critical Role of Insertion Preference for Invasion Trajectory of Transposons
|
evolutionary biology
|
Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents
|
genomics
|
Fatty sweet symphony: Decoding distinct ganglioside patterns of native and differentiated mesenchymal stem cells by a novel glycolipidomics profiling strategy
|
biochemistry
|
Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of malignant pleural mesotheliomas to CDK4/6 inhibition
|
cancer biology
|
A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening
|
pharmacology and toxicology
|
Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in the liver
|
physiology
|
Elp1 is required for development of visceral sensory peripheral and central circuitry
|
neuroscience
|
A population of gray matter oligodendrocytes directly associates with the vasculature
|
neuroscience
|
INRI-seq enables global cell-free analysis of translation initiation and off-target effects of antisense inhibitors
|
microbiology
|
Low-cost genomics enable high-throughput isolate screening and strain-level microbiome profiling
|
microbiology
|
Trascriptome meta-analysis of microalga Dunaliella tertiolecta under stress condition
|
genomics
|
Two-photon microscopy in vivo reveals brain vessel type-specific loss of glycocalyx caused by apoM/S1P signaling impairment.
|
neuroscience
|
Hypervoxels: A Multidimensional Framework For The Representation And Analysis Of Neuroimaging Data
|
neuroscience
|
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