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### Human: Medtronic's Lead Integrity Alert (LIA) software algorithm is useful for detecting abnormal parameters across various ICD-lead families . However, its utility in assessment of the Biotronik Linox™ family of high-voltage (HV) leads is unknown . Does lead Integrity Alert be Useful for Assessment of Performance... |
### Human: The Ethical Committee approved the study . Patients provided written informed consent and received a whole breast workup . Lesions were assessed by BI-RADS, Tsukuba score (TS) and strain ratio (SR) Does elastography complement Ultrasound as Principle Modality in Breast Lesion Assessment?### Assistant Beside... |
### Human: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein convertase that posttranslationally promotes the degradation of the low-density lipoprotein receptor (LDLR) in hepatocytes . In boys, plasma PCSK9 decreased with age, whereas the inverse was true for girls . Is plasma PCSK9 associated with a... |
### Human: NAC chaperone activity is considered necessary to retroviral Gag functions, but so far, NAC activity has only been confirmed for HIV-1 and RSV Gag polyproteins . The nucleocapsid (NC) domain of Gag is proposed to be crucial for interactions with nucleic acids . The major function of matrix (MA) domain is ta... |
### Human: The ability of RPE to phagocytose rod outer segments decreased as a function of aging of Bruch's membrane . Phagocytic activity was quantified by flow cytometry of harvested cells . Does bruch 's membrane aging decrease phagocytosis of outer segments by retinal pigment epithelium?### Assistant Aging of huma... |
### Human: Leukotriene B4 is a potent inflammatory lipid mediator that binds to LTB4 receptor 1 (BLT1) Ligation of BLT1 by LTB 4 plays an important role in the recruitment of effector memory CD8+ T cells into the airways of sensitized and challenged mice . Effector memory memory T cells were generated from ovalbumin(2... |
### Human: CXCR4 (X4) HIV-1 tropism has been associated with severe immunodeficiency . We investigated the temporal changes in the genotype-predicted tropism frequency and the phylogenetic relationships between the R5 and non-R5 clades . Is the temporal increase in HIV-1 non-R5 tropism frequency among newly diagnosed ... |
### Human: The aim of this study was to determine whether prehospital intubation (ETI) and chest tube placement is unnecessarily time consuming in severely injured patients . A retrospective, multicentre study including all adult patients (ISS ≥9; 2002-7) of the Trauma Registry of the German Society of Trauma Surgery ... |
### Human: A protein complex consisting of hMre11, hRad50, and Nbs1 (MRN) has been identified as a critical component in repair of DNA DSBs . The study investigates whether the expression of a truncated form of NBS1 interrupts the function of the MRN complex and therefore enhances cisplatin-induced DNA damage and cyto... |
### Human: Atrial fibrillation arises in 20-30% of patients with sick sinus syndrome, increasing the risk of systemic embolization and mortality . The aim of this study was to examine the clinical determinants of development of paroxysmal atrial fibillation before implantation of a pacemaker . Does atrial size indepen... |
### Human: The goal of this study was to determine if there is a relationship between the T2-relaxation time of hepatic parenchyma and the histologic grade of liver fibrosis . 123 patients with hepatitis C underwent both routine, clinical liver MRI and biopsy within a 6-month period, between July 1999 and January 2010... |
### Human: Medication adherence was calculated as proportion of days covered for filled prescriptions . Rates of medication nonadherence were 28.8% for beta-blockers, 21.6% for ACE inhibitors, 26.0% for statins . Is medication nonadherence associated with a broad range of adverse outcomes in patients with coronary art... |
### Human: Genotypes at the locus of the glucose-6-phosphatase, catalytic 2 gene (G6PC2) are known to affect regulation of fasting glycaemia . We determined the genotype of patients with monogenic diabetes and glucokinase gene mutations (GCK-MODY) and correlated the genotypes with HbA(1c) levels . Is hbA1c-based diabe... |
### Human: Oleic acid, a representative unsaturated fatty acid, has been shown to be a useful reagent to induce these cellular alternations, however, the detailed mechanism still remains to be elucidated . The downstream mediator of oleic acid-treatment was identified in the epidermal keratinocyte . Do epimorphin-deri... |
### Human: Human recombinant decay-accelerating factor (DAF) reduces tissue damage in a porcine model of hemorrhagic shock . Administration of DAF significantly reduced intestinal and lung tissue damage . DAF treatment improved hemorrhage-induced hyperkalemia . Does decay-accelerating factor mitigate controlled hemorr... |
### Human: Four peripheral blood markers were evaluated in 50 patients diagnosed with UCRC at the time of patients' first visit to the hospital . Each was scored +1 or 0 for that marker . Is new Prognostic Indicator Useful for Predicting the Survival of Patients with Unresectable Advanced Colorectal Cancer?### Assista... |
### Human: ALDO potentiates the effects of angiotensin II (Ang II) in rats . The experiments were performed in a stasis-induced venous thrombosis model in male Wistar, normotensive rats . Valsartan (VAL; 10mg/kg), a selective AT1 receptor antagonist, was administered in a single bolus injection before ALDO infusion . ... |
### Human: Cyclosporin had an acute hypertensive effect while having no effect on sodium excretion or renal function . The earliest renal effect of the drug was on water handling . Does cyclosporin-induced hypertension precede renal dysfunction and sodium retention in man?### Assistant Our findings contradict previous... |
### Human: A cross-sectional study was performed in Bogotá, Colombia, during 2006 in 263 males from the Colombian Air Force . NAFLD was detected in 26.6% (n=70) of the subjects . Thirty four individuals had complete MS criteria (48.5%) NAFLd was associated with higher insulin levels (11.0±5.1) Is nonalcoholic fatty li... |
### Human: Tempe extract showed a high antibacterial activity against B. cereus ATCC 14579 based on optical density and viable count measurements . This growth inhibition was manifested by a 4 log CFU ml(-1) reduction, within the first 15 min of exposure . Tempe extracts also rapidly inactivated B. Cereus spores upon ... |
### Human: Chlorhexidine-silver sulfadiazine (CHSS)-impregnated catheters have been found to decrease the risk of catheter-related bloodstream infection (CRBSI) and central venous catheter (CVC)-related costs . Are chlorhexidine-silver sulfadiazine-impregnated venous catheters efficient even at subclavian sites withou... |
### Human: SiHa cervical cancer cells were transfected with two doses of intracellular active Notch . Moderate Notch activation contributed to increased viability and anchorage independent growth . High levels of Notch led to a change in AP-1 complex composition, from cJun/cFos to cJun-Fra1 dimers . Is the functional ... |
### Human: The aim of this study was to assess the differential influence of thoracic and lumbar epidural anaesthesia and analgesia (EAA) on blood lactate levels and central venous oxygen saturation (ScvO2) as parameters of global oxygen supply/demand ratio . Lactate, ScvO 2 and PDR(ICG) were measured postoperatively ... |
### Human: Diabetes education is critical to optimum diabetes care . Despite the significant clinical and personal rewards offered by diabetes education, programmes are underused . A systematic search of the following databases was conducted for the period from 2005-2015 . Choose reasons why patients referred to diabe... |
### Human: The aim of this study was to explore the impact of normoxic and hypoxic cell-culture conditions on the expression and secretion of adipose mesenchymal stem cells (ADMSCs)-derived paracrine molecules . The effect of hypoCM on cardiomyocytes proliferation and migration was assessed . A rat model of myocardial... |
### Human: The scald (III degrees TBS 10-15%) was caused by exposing these area to hot water at 90 degrees C for 40 seconds . Every rabbit was injected CPZ (25 mg/kg) three times . The concentration in blood was shown two times higher than after subeschar injection . Do [ Experimental studies on the pharmacokinetics o... |
### Human: EuroSCORE is a simple risk model able to predict early and late mortality after cardiac surgery . Recent data suggest this score may also predict early clinical outcome after percutaneous coronary intervention (PCI) Data regarding EuroSCore usefulness to predict late outcome after PCI in unselected patients... |
### Human: A total of 60 patients were included in this study within 2 to 3 days after meniscus repair . No patients with concomitant ligament reconstruction or cartilage repair surgery were included . Patients were seen for follow-up at 3 months, 1 year, and 2 years . The Knee Osteoarthritis Outcome Score (KOOS), Teg... |
### Human: The most common reasons reported for discontinuing breastfeeding were mother's preference (39%) and low milk supply (21%) Women who were younger, were less educated, were non-Hispanic black, were unmarried, and had no prior breastfeeding experience were the most likely to discontinue breastfeeding due to mo... |
### Human: Phorometric findings have been observed to change with stress . We test the hypothesis that postnearwork phorias predict symptoms that have been theorized to result from nearwork-induced visual stress . Do nearpoint phorias after nearwork predict ADHD symptoms in college students?### Assistant Phorias postn... |
### Human: In the general population, aortic arch calcification (AAC) can predict cardiovascular mortality . We conducted a prospective study to investigate factors associated with AAC in hemodialysis patients and examined its prognostic value in long-term outcome . High-grade calcification was associated with cardiov... |
### Human: Low-density lipoprotein (LDL) oxidation in the arterial intima plays a pivotal role in atherogenesis . Under physiologic conditions, several mechanisms protect LDL against oxidation . Conditions of acute phase response, including acute myocardial infarction, may be expected to result in increased susceptibi... |
### Human: Grey matter volume loss is a central characteristic of bipolar disorder (BD) and schizophrenia (SCZ) The aim of this study is to measure the effect of diagnosis and ACE on GM volume in a sample of patients with BD or SCZ compared with healthy controls (HC) We studied 206 depressed BD patients, 96 SCZ patien... |
### Human: The relative contributions of administered oestrogen and progestin to protection of the post-menopausal skeleton remain unclear . We have compared the effect on spinal bone mineral density of continuous combined oestgen/medroxyprogesterone therapy with that of unopposed oestrogens . Does medroxyprogesterone... |
### Human: A prospective serological study was carried out on consecutive adult adult pneumonia patients from July 1987 to July 1988 . Acute and convalescent sera were tested in batches for antibodies against Legionella pneumophila serogroup 1, C. pneumoniae, Chlamydia psittaci, Coxiella burnetii (phase-2 antigen) and... |
### Human: Calcitonin gene-related peptide (CGRP) is a major neurotransmitter of the capsaicin-sensitive sensory nerves . It is unknown whether CGRP protects against EPCs senescence . Does calcitonin gene-related peptide inhibit angiotensin II-induced endothelial progenitor cells senescence through up-regulation of kl... |
### Human: The aim of this study was to explore the effect of maternal vitC status on fetal and placental development in guinea pigs . Twenty pregnant Dunkin Hartley guinea pig were randomized into four groups to receive diets either sufficient (918 mg/kg CTRL) or deficient (100mg/kg DEF) in vitC . Does maternal vitam... |
### Human: Four patients (10 plug cartilages) were examined three times by T2 mapping at 1, 3, and 6 months using a 3.0 Tesla MR scan system . Quantitative mean (full-thickness) T2 values were calculated in the transplanted area and control cartilage . Does [ Quantitative T2 mapping evaluate the repaired articular car... |
### Human: Elderly people living in residential care facilities are more likely to fall . The aim of this study was to investigate the prediction accuracy of the Downton fall risk index among older people . The accuracy of predictions did not improve when applying a fall definition in which falls were excluded . Does ... |
### Human: The possible involvement of claudin-1 (CL-1), one of the major tight junctional proteins (TJPs), was investigated in the tumorigenesis of colorectal cancer . Adenocarcinoma tissue and paired normal mucosa specimens were resected from surgical specimens of patients . The expression of CL-1 at the mRNA and pr... |
### Human: Allicin, the main biologically active compound derived from garlic, has been shown to exert various anti-oxidative and anti-apoptotic activities in in vitro and in . vitro studies . PD related neuronal injury is associated with oxidative stress and mitochondrial dysfunction . Study found allicin significant... |
### Human: 473 patients with a birth weight under 1500 g were included in a prospective observational study for adverse events that included cardiorespiratory events, local reactions and fever . Apnea appeared significantly more often in children who were younger at the time of immunization . Do very low birth weight ... |
### Human: Blood was collected from all dogs directly into collection tubes containing 3.2 or 3.8% citrate . Prothrombin time (PT), activated partial thromboplastin time (aPTT) and fibrinogen concentration were measured by use of 3 clot-detection assay systems . Does effect of citrate concentration on coagulation test... |
### Human: Lamotrigine is effective in the treatment of persons with bipolar disorder . It is also effective in reducing the effects of ketamine in humans . It also decreases the perceptual abnormalities produced by ketamine . Does lamotrigine prevent ketamine but not amphetamine-induced deficits in prepulse inhibitio... |
### Human: Saccadic eye movements are used to rapidly align the fovea with the image of objects of interest in peripheral vision . In children there is a high preponderance of quick latency but poorly planned saccades that consistently fall short of the target goal . Do the human frontal oculomotor cortical areas cont... |
### Human: The vat gene mutant strain of APEC-O1 did not affect the growth and resistance to environment stress . Inactivation of the APEC gene resulted in enhanced motility, diminished agglutination, decreased biofilm formation and attenuated virulence . Does [ Vacuolating autotransporter toxin affect biological char... |
### Human: Study involved 300 patients with SCCE who underwent either EMR or ESD from March 1994 to July 2007 . Patients underwent endoscopic resection and then were followed by periodic endoscopy for 8 to 174 months (mean 65 months) Disease-free survival was significantly better with ESD . Is endoscopic submucosal di... |
### Human: Microarray-based comparative genomic hybridization identified a microamplification harboring a single gene (CACNA1E) at 1q25.3 in 6 of 76 (7.9%) Wilms' tumors . Overexpression of the gene was associated with DNA copy number and tumor relapse . Does amplification and overexpression of CACNA1E correlate with ... |
### Human: A rodent model of liver disease sharing these phenotypic features would assist in the study of underlying mechanisms and testing of theraphetic drugs . Bile duct ligation caused sarcopenia, liver, cardiovascular and renal dysfunction whereas CCl4 mice demonstrated no clinical abnormalities . Plasma eicosano... |
### Human: Few studies have focused on factors affecting outcome in patients with multiple myeloma (MM) treated with thalidomide-based therapy . We investigated factors affecting response, progression-free survival (PFS), and overall survival (OS) We analyzed demographics and disease-related characteristics to search ... |
### Human: Previous work has identified prostate-specific membrane antigen (PSMA) as a potential antigen for T-cell recognition . One vaccination strategy that is being pursued in the clinic utilizes peptide-pulsed peripheral blood mononuclear cells . Is the HLA-A2-restricted PSMA peptide LLHETDSAV poorly immunogenic ... |
### Human: Polyanions, including RNA and glycosaminoglycans have been identified as factors that contribute to the propagation, transmission and pathogenesis of prion disease . Recent studies have suggested that the contribution of these cofactors to prion propagation may be species specific . Does glycosaminoglycan s... |
### Human: Parkinsonian (PD) patients undergo cyclic antero-posterior and medio-lateral transfers of the centre of foot pressure . This event might be potentially exploited for improving gait in these patients . Does alternate rhythmic vibratory stimulation of trunk muscles affect walking cadence and velocity in Parki... |
### Human: Magnesium deficiency is thought to be a risk factor for cerebrovascular atherosclerosis and complications . We investigated the prognostic impact of Mg serum levels with respect to the occurrence of neurological events in patients with advanced atheroscleric disease . We prospectively studied 323 patients w... |
### Human: The antimicrobial properties and toxicity of Euphorbia plant latex should make it a hostile environment to microbes . However, when specimens from Euphorbian spp. were propagated in tissue culture, microbial growth was observed routinely . Is euphorbia plant latex inhabited by diverse microbial communities?... |
### Human: IpsA is a LacI-type transcriptional regulator conserved among Mycobacteria and Corynebacteria . IpsA triggers myo-inositol formation by activating ino1, which encodes inositol phosphate synthase . Is ipsA , a novel LacI-type regulator , required for inositol-derived lipid formation in Corynebacteria and Myc... |
### Human: The aim of this study was to evaluate whether cyclosporine A (CsA)-based Graft vs. Host Disease (GvHD) prophylaxis with enteric-coated mycophenolate sodium (EC-MPS) instead of MMF or methotrexate (MTX) reduces GvHD incidence and lowers gastrointestinal (GI-) toxicities . Does enteric-coated mycophenolate so... |
### Human: Study included 160 patients with IBS, 40 patients with other gastrointestinal diseases, and 50 healthy individuals (controls) Patients were observed for 4 weeks, placed on an elimination diet (without cow's milk and derivatives, wheat, egg, tomato, and chocolate) and kept a diet diary . Those who reported i... |
### Human: In 2004, the Kenya Medical Research Institute and the US Army Medical Research Unit--Kenya surveyed adults in Samburu, Malindi, and Busia districts to determine socioeconomic risk factors for infection . Sociodemographic, health, and antimalarial data were collected along with blood for malaria testing . Ar... |
### Human: AKI is a serious early complications in patients with acute pancreatitis (AP) that signifcantly increases mortality rates compared to patients without AKI . The early diagnosis of AKI during its treatable phases can improve outcomes for this group of patients . Is urine NGAL useful in the clinical evaluatio... |
### Human: Many falls occur during walking when the base of support is narrowest in the mediolateral (ML) direction . Good lateral harmonic stability in gait may be important for minimising fall risk in older people . Traditional ML harmonic ratio may be sub-optimal measure of gait quality because of insufficient freq... |
### Human: The purpose of this study was to determine if exercise, whether continuous (CE) or intermittent (completed in either two (IE 2) or three (IE 3) exercise sessions) alters reverse cholesterol transport or low density lipoprotein (LDL) particle size . The IE 3 group had significant increases in HDL(2)-C at 24 ... |
### Human: Rottlerin (5 mg/kg, intra-peritoneal (i.p.) administered 20 h prior to the first saline conditioning trial diminished subsequent drug- and stressor-primed reinstatement of the extinguished CPP . Does rottlerin impair the formation and maintenance of psychostimulant-supported memory?### Assistant These resul... |
### Human: The 2007-2009 financial crisis strongly emphasized the need to define new ways and measures to study and assess the stock market dynamics . The S&P500 dynamics during 4/1999-4/2010 is investigated in terms of the index cohesive force (ICF) The stiff state is also marked by strong effect of the market index ... |
### Human: X-rays of American white children (5-14 years of age) with simple hypodontia were compared to a comparable group with all teeth present (n=206) Tooth formation was decidedly more frequently asymmetric in those with hypodentia . Is bilateral asymmetry of tooth formation elevated in children with simple hypod... |
### Human: Studies have revealed the ability of clinicopathologic parameters and gene expression to predict HCC prognosis . There has been little systematic effort to compare the two types of predictors or combine them in a comprehensive model . Tumor and adjacent non-tumor liver tissues were collected from 272 ethnic... |
### Human: The aim of the work was to verify the applicability of quality goals based on biological variation . We evaluated the performance of the laboratories participating in two Italian EQAS . The results were obtained during 2007 for 27 components in the regional scheme of Lombardy and in the national scheme of P... |
### Human: The study aims to verify the predictive value of positive poppy seed and morphine sIgE assays results . None of the 22 patients demonstrated objective or subjective symptoms on provocation with morphine and/or codeine . Are igE to Poppy Seed and Morphine Useful Tools to Diagnose Opiate Allergy?### Assistant... |
### Human: Male Wistar rats were injected with streptozotocin [60 mg/kg, intravenously (i.v.)] or the vehicle (0.9% NaCl) and studied 3 weeks later . The diabetic and control rats had similar mean arterial pressure (MAP) and total peripheral resistance (TPR) Noradrenaline (NA) increased in vivo left ventricular contra... |
### Human: This study was designed to determine the prognostic value of immunohistochemical tumor marker expression in a population of patients with node-negative esophageal cancer treated with complete resection alone . A panel of 10 tumor markers were chosen for immunohistsic analysis . Multivariable analysis demons... |
### Human: Cryptic species are two or more distinct but morphologically similar species that were classified as a single species . During the past two decades we observed an exponential growth of publications on cryptic species . It has been proposed that their distribution is non-random across taxa and biomes . Are c... |
### Human: DLL4 expression and microvessel density (MVD) were detected by immunohistochemistry in 51 human high-grade malignant glioma tissue samples . The vessel maturation index (VMI) was calculated as the percentage of a-smooth muscle actin (a-SMA)-positive vessels in relation to the amount of CD31-positive vessels... |
### Human: Symptoms, endoscopy, and histology were assessed in 46 patients using Pouchitis Disease Activity Index (PDAI) Patients with pouchitis had significantly higher mean total PDAI scores . 25% of patients with symptoms suggestive of pouchitis did not meet the PDAi diagnostic criteria for pouchitis . Are endoscop... |
### Human: The rapid respiration rate of cotton (Gossypium hirsutum) fruits (bolls) produces a concentrated CO2 microenvironment around the bolls and bracts . Arguably, this microenvironment has existed for at least 1·1 million years since the appearance of tetraploid cotton . Are cotton bracts adapted to a microenvir... |
### Human: The aim of this study was to investigate whether risk factors for embolism would promote thrombus formation in patients with nonvalvular atrial fibrillation (NVAF) The beta-TG level was higher in NVAF patients than in control subjects . Only NVAF (OR, 10.30; 95% CI, 5.67 to 18.72) emerged as a predictor of ... |
### Human: Sunlight and air temperature are environmental parameters with considerable influence upon autoimmunity . Their impact on idiopathic bullous pemphigoid (BP) was studied in a prospective series of 27 patients . Skin involvement and the onset of disease showed an immediate and cumulative pattern of response t... |
### Human: Apo H mRNA levels and protein content were measured in hepatic and adipose tissue (subcutaneous and visceral) samples obtained during bariatric surgery . APOH plasma levels were significantly associated with triglycerides (p<0.001), all the components of triglyceride-rich lipoproteins (p) and RBP4 levels . ... |
### Human: Analysis of chromosomal sperm content by fluorescence in situ hybridization (FISH) using probes for chromosomes 1, 15, 16, 17, 18, X, and Y . Six male carriers of balanced chromosome rearrangements, one with normal sperm parameters and five with oligoasthenoteratozoospermia . Does fluorescence in situ hybri... |
### Human: The role of rapamycin in pancreas stem cells remains to be clearly elucidated . Herein we evaluated the effects of the drug on porcine neonatal pancreis cell clusters (NPCCs) The expressions of insulin, pancreatic and duodenal homeobox-1, and NeuroD/Beta2 genes were down-regulated via rapamycine treatment .... |
### Human: Patients with Crohn's disease (CD) often exposed to ionizing diagnostic radiation with inherent risks from protracted exposure . We analyzed 170 patients with CD (114 treated with anti-TNF and 56 treated with corticosteroid) Is anti-TNF therapy associated with a reduction in radiation exposure in patients w... |
### Human: ATM may regulate oxidative stress-induced signaling cascades involving nuclear factor-kappaB (NF-KappaB), a transcription factor that is upstream of a wide variety of stress-responsive genes . ATM gene knockdown with the use of an antisense oligonucleotide suppressed OGD-induced ATM protein expression . ATM... |
### Human: INACTINE PEN110 chemistry is being used to develop a process for preparing pathogen-reduced red blood cell concentrates (RBCC) Does broad-spectrum virus reduction in red cell concentrate using INACTINE PEN110 chemistry?### Assistant The results from the study demonstrate for the first time that a pathogen-r... |
### Human: Between January 2000 and December 2006 a total of 387 patients with T1-2N0+ breast cancer were treated with breast-conserving surgery and radiotherapy, with and without hormone therapy and chemotherapy . Five-year local relapse-free survival rates were 97.3% ± 1.5% for patients who did not receive chemother... |
### Human: Mucous cell metaplasia is considered the critical preneoplastic lesion for gastric cancer . Previous investigations have shown that infection of Helicobacter felis or acute parietal cell loss with the drug DMP-777 leads to the emergence of a type of metaplastic metaplia . We hypothesized that SPEM arises fr... |
### Human: The aberrant expression of microRNAs has been demonstrated to play a crucial role in the initiation and progression of gastric cancer . We aimed to investigate the mechanism of microRNAAs in the regulation of GC pathogenesis . Inhibition of miR-126 effectively reduced migration and invasion of GC cell lines... |
### Human: Nodules (n = 14) were examined with monoclonal antibodies recognizing the DC differentiation/activation markers CD83, CMRF44, and CD1a . Cells expressing CMRf44 were common in rheumatoid nodules, comprising 22% of nucleated cells versus 13% in synovial membranes . Are cells expressing dendritic cell markers... |
### Human: Study used functional magnetic resonance imaging to compare hemodynamic response in mesocorticolimbic structures after exposure to alcohol tastes . Results indicated that DRD4 VNTR >7 repeat individuals (DRD4.L) had significantly greater response to alcohol cues in the orbitofrontal cortex, anterior cingula... |
### Human: 39 microscopy centres in Anantpur district and 34 in Nellore district (one per 100,000 population) each with a trained microscopist . Periodic follow-up sputum microscopy is performed for all tuberculosis (TB) patients on treatment . Results are recorded in a laboratory register . Is repeated sputum microsc... |
### Human: The aim of this study is to make sure whether polymorphism Ala54Thr of gene Fatty Acid-Binding Protein 2 (FABP2) is associated with stroke risk in Hunan Han population of China . A total of 206 cerebral infarction (CI), 185 cerebral hemorrhage (CH) and 172 controls were enrolled in our study . Is polymorphi... |
### Human: The study aimed to develop a gastrointestinal (GI) dysfunction score predicting 28-day mortality for adult patients needing mechanical ventilation (MV) 377 adult patients from 40 ICUs with expected duration of MV for at least 6 h were prospectively studied . Absent bowel sounds and GI bleeding were the symp... |
### Human: The objective is to determine if muscle MRI is useful for assessing neuropathy severity . Clinical, MRI and electromyography (EMG) examinations were performed in 17 patients with focal lower limb neuropathies . MRI amyotrophy was significantly increased in severe, chronic, and proximal neuropathynepathies a... |
### Human: Mixed hematopoietic chimerism has not been achieved in large animals using methods that are readily applicable to human recipients . Cardiac allografts transplanted into untreated recipients across similar minor antigen barriers were rejected within 44 days . Does mixed hematopoietic chimerism induce long-t... |
### Human: MMP-13 deletion alone abrogated collagenolytic activity in lesions, indicating a predominant role for MMPs in this process . Analysis of aortic root sections indicated that lesions of MMP's/MMP-8/Mmp-13-deficient and MMP/13-Deficient mice accumulate more fibrillar collagen than those of mice . Does matrix m... |
### Human: An experiment was conducted to investigate the effects of rotation direction change on MS onset and severity . MS onset was fastest when drum rotation direction changed . MS symptoms significantly affected were dizziness, stomach awareness, and nausea . Does rotation direction change hasten motion sickness ... |
### Human: Late onset asthma is associated with more severe disease and higher morbidity than in younger patients . Evidence on impact of patient age on diagnostic assessment of asthma in a specialist setting is sparse . Is the level of specialist assessment of adult asthma influenced by patient age?### Assistant A lo... |
### Human: The goal of this study was to determine whether eosinophil-active cytokines, including IL-3, IL-5, or granulocyte-macrophage colony-stimulating factor, are released into the lung 24 hours after segmental antigen challenge of ragweed allergic subjects . Subjects with allergic rhinitis were challenged with re... |
### Human: Fifteen untreated female patients with rheumatoid arthritis (RA) and 7 healthy female controls were infused with epinephrine (0.05 microg/kg/min) for about 20 min . Plasma levels of adrenocorticotropic hormone (ACTH) and cortisol, 17-hydroxyprogesterone (17OHP), and dehydroepiandrosterone sulfate (DHEAS) we... |
### Human: A total of 75 patients with invasive bladder cancer underwent radical cystectomy with extended lymphadenectomy . SNs were identified by preoperative lymphoscintigraphy, intraoperative dynamic lymphoscintsigraphy and blue dye detection . Of the 32 lymph node positive cases, of whom 13 had all lymph node meta... |
### Human: Stroke Therapy Academic Industry Round Table criteria have been proposed for stroke studies . Stroke therapy academic industry Round Table has been proposed . We aimed to compare susceptibility to ischemia in hypertensive rats with those in normotensive controls in a rat model . Do spontaneously hypertensiv... |
### Human: Aim was to examine capacity of U46619 (a stable thromboxane A2 mimetic) to mediate release of endothelium derived relaxing factor (EDRF) from bovine aortic endothelial cells . Does activation of bovine endothelial thromboxane receptors trigger release of prostacyclin but not EDRF?### Assistant In contrast t... |
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