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The literature on online communities shows that successful peer-curation communities, those able to attract and retain enough participants, can provide scalable knowledge-curation solutions comparable in quality to the quality of professionally curated content . Hence, the success of online research identity management systems may depend on the number of contributors and users they are able to recruit, motivate, and engage in research identity data curation. A significant body of research exists on what makes peer knowledge-creation and knowledge-curation groups and communities successful. Some of the issues and factors that may affect the success of peer curation of knowledge are peer motivations to contribute, the effectiveness of work articulation and coordination, task routing, and quality control (e.g., [10–12]). Researchers’ participation in the curation of research identity data has typically not been investigated, however. Furthermore, people may value different motivations at different levels . Therefore, it is important to identify the value structure underlying researchers’ motivations for maintaining and sharing their research identity data. This article addresses the need for a greater understanding of how to design scalable solutions for research information management by examining how researchers participate in RIMSs, their motivations for participation, and the value structures underlying those motivations. We investigated the following research questions:
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study
| 99.94 |
Roles are important in understanding member participation in an online community and in explicating and organizing the community’s work. Community roles can be formally defined and assigned together with related activities and power privileges, or they can be undertaken informally through self-selection . Users may play different roles at the same time or at different times. Preece and Shneiderman proposed a conceptual framework to characterize users’ successive levels of participation or roles in online social communities as evolving from reader to contributor, to collaborator, and finally to leader. Furthermore, users may abandon a community if it no longer meets their needs and objectives . Wu and colleagues found that researchers’ engagement in online RIMSs changed as their career status changed and influenced their perception of the costs and benefits of using a specific RIMS. Some researchers gave up curating their RIMS profile and actively promoting their research through the RIMS after they secured jobs and were no longer motivated by the objectives of those activities. Haustein and Larivière analyzed journal articles from four disciplines (i.e., biomedical research, clinical medicine, health, and psychology) in Mendeley and found that the majority of Mendeley users were junior researchers, such as doctoral students, postgraduate students, and postdoctoral researchers (aka postdocs).
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other
| 97.8 |
Participation in RIMSs may also vary by discipline. Thelwall and Kousha examined the coverage of Scopus-indexed articles with DOI identifiers in ResearchGate and found that the arts, humanities, and some areas of social sciences were highly underrepresented relative to other disciplines. Mas-Bleda and colleagues , who studied the online presence of highly cited researchers working at European institutions, found that an online presence in a RIMS was higher among researchers in the social sciences, engineering, and health sciences than among those in the life sciences and physical sciences.
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other
| 99.7 |
Preece and Shneiderman conducted a literature review to identify possible motivations for different levels of participation in online communities. For example, they found that a welcoming environment, safety, privacy, support for newcomers, encouragement by individuals they trusted or respected, contacts to answer their questions, and frequently updated and well-organized content were some factors that motivated readers. The ease of making contributions, recognition of the quality and quantity of their contributions, and gaining visibility or awards for their contributions were some factors that encouraged contributors. Trust and empathy that promoted belonging to the community, altruism, and the desire to build a reputation were some factors that encouraged collaborators.
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review
| 99.9 |
The literature on online communities has shown that volunteer knowledge curators in open peer-production systems such as Wikipedia are mostly driven by intrinsic motivations, such as their interests in specific areas, which are often shaped by their organizational and ethnic affiliations, hobbies, professional experiences and expertise, and beliefs . For example, Nov found that enjoyment or having fun was the top motivation for contributing to English Wikipedia. It is noteworthy that these intrinsic motivations could produce both constructive and disruptive behaviors (i.e., trolling and vandalism) toward the community’s objectives .
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other
| 99.9 |
In addition to Wikipedia, researchers examined users’ motivations for contributing to other online communities. Nov and colleagues found a positive relationship between the motivation to build a reputation in the community and the number of tags contributed in Flickr. Similarly, in an earlier study examining an online network of legal professionals, Wasko and Faraj found a significant positive effect on the motivation to build a reputation from the quality and volume of knowledge contributed. Hars and Ou examined the motivations of contributors to free and open source software (FOSS) projects. They identified two categories of motivations: internal and external. Internal motivations included factors related to self-determination, as well as altruism and community identification. The external motivation category included factors related to future rewards (e.g., enhanced status and self-efficacy) and personal needs for open source software functionalities. As motivations to participate in FOSS projects, Lakhani and Wolf identified self-identification with a community and a sense of obligation to contribute, along with the motivations of a sense of enjoyment and receiving rewards.
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study
| 82.1 |
Previous studies have also examined motivations for specific types of knowledge-sharing activities, such as question answering. For instance, Raban and Harper conducted a literature analysis and identified 14 motivations for answering questions online, and then grouped them into intrinsic and extrinsic categories. Similarly, Ringel Morris and colleagues identified 10 motivations for answering questions asked on social networking platforms such as Facebook and Twitter: altruism, expertise, properties of the question, nature of the relationship, connecting socially, free time, social capital, obligation, humor, and ego.
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study
| 86.25 |
The theory of planned behavior provides a conceptual framework for users’ behavioral intentions . According to this theory, personal attitudes toward the behavior, social norms or pressure associated with the behavior, and perceived self-efficacy or behavioral control over the behavior can affect behavioral intentions. Lin combined belief and attitude constructs with intrinsic and extrinsic motivation constructs from the literature to study the motivational structure of knowledge sharing in organizations. Lin’s survey instrument included six constructs: (1) expected organizational rewards, (2) reciprocal benefits, (3) knowledge self-efficacy, (4) enjoyment in helping others, (5) attitudes toward knowledge sharing, and (6) knowledge-sharing intentions.
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study
| 99.94 |
In addition, groups of contributors to different information systems can be driven by different motivations. Huffaker and Lai examined workers’ motivations for contributing knowledge at IBM. They found that new and younger workers were motivated by achieving recognition from the management, whereas older workers and workers who had worked longer for the company were driven more by altruistic factors, such as a desire to provide mentorship and help the community. Oreg and Nov found that contributors of open source software were mostly motivated by reputation building and self-development, whereas contributors of open source content were driven more by altruism. Moreover, activities in RIMSs that involved targeted sharing of information with specific researchers could be viewed as forms of collaboration (e.g., answering questions). Stvilia and colleagues found that when deciding whether to collaborate with another researcher, researchers gave priority to their intrinsic motivations, such as the quality (i.e., interestingness) of ideas a potential collaborator might have.
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other
| 99.44 |
One of the indirect indicators of a researcher’s reputation in scholarly communication is her or his scholarly impact, as measured by the number of citations the researcher’s works receives. Hence, researchers’ participation in RIMSs can also be motivated by their desire to increase their citation counts or other alternative metrics of impact. Moed suggested that sharing a publication early by posting its preprint in a preprint database such as arXiv could result in a higher citation count. Other studies (e.g., ) showed that publication read counts in RIMSs correlated with citation counts.
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other
| 99.9 |
The design of this study was guided by an analysis of the literature reviewed in the previous section. Existing scales of attitudes and motivations were selected from the literature to guide the design of an interview protocol and a survey questionnaire. The study began by conducting semistructured interviews of 15 researchers between January and July of 2016. The researchers interviewed represented 9 fields of study, 10 institutions, and 5 seniority categories (3 full professors, 3 associate professors, 3 assistant professors, 3 postdocs, and 3 doctoral students).
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study
| 99.94 |
Two authors independently coded all the interviews by use of an initial coding scheme based on the literature analysis. After comparing, discussing, and resolving any differences in their coding, the two authors formed a new coding scheme with emergent codes and subcategories, and then recoded all the interviews. A detailed account of the findings from the qualitative part of the study is presented elsewhere .
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study
| 99.9 |
The qualitative findings were then used to expand and refine the interview questions and develop a survey instrument. The survey instrument was pretested with 9 participants (4 assistant professors, 2 postdocs, 1 associate professor, and 2 graduate students) representing 6 disciplines (Library and Information Science, Chemistry, Mathematics, Business, Education, and Sports Management) for readability and validity. The finalized survey was distributed online to 1,680 researchers in the fall of 2016 by using Qualtrics survey software. Participants were recruited from 115 universities categorized as Doctoral Universities with Highest Research Activity (DUHRA) in the Carnegie Classification of Institutions of Higher Education . E-mail addresses were collected manually from departmental websites, and participants were contacted individually. When recruiting, an effort was made to obtain a sample stratified by seniority. The following five levels of seniority were used: graduate students, postdocs, assistant professors, associate professors, and full professors.
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study
| 99.94 |
To be eligible to participate, a participant had to have at least one peer-reviewed publication. The survey instrument was composed of 46 questions. Before participants were interviewed or completed an online survey, they were given a consent form approved by the Human Subjects Committee of Florida State University (FSU HSC Number: 2015.16120). The form contained information about the project, including information about potential risks associated with participation in the data collection. Participants who finished an interview or a survey were e-mailed a $30 Amazon gift card.
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study
| 99.94 |
Participants completed early questions on the survey at higher rates, and 412 participants representing 80 DUHRA universities finished the entire survey, resulting in a response rate of 25%. Participants were approximately evenly distributed by gender and seniority, but there were slightly higher numbers of postdocs and assistant professors. Their disciplines were categorized according to the top five fields of study. However, the categories were distributed unevenly, with the Social Sciences category being the largest and the Humanities category being the smallest (see Table 1).
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other
| 90.06 |
In the qualitative analysis, the authors used the method of conceptual categorization to categorize participants into three levels of participation in RIMSs based on the research information management tasks reported in the interviews: Readers, Record Managers, and Community Members . Preece and Shneiderman’s Reader to Leader framework was used as a conceptual guide when grouping tasks into levels and determining labels for the groupings. Those classified as Readers might or might not have a profile in a RIMS, but they did not maintain it and did not contribute to the RIMS. They did not answer other members’ questions, and they did not endorse other members for their expertise. Record Managers were defined as researchers who maintained their profiles in a RIMS but who did not contribute to the RIMS beyond that. Finally, Community Members were defined as those who not only maintained their profiles, but also contributed to the RIMS community by answering other members’ questions or endorsing other members’ expertise.
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other
| 90.7 |
Thus, the three participation levels were based on whether researchers completed the following three activities: maintained a RIMS profile, answered questions, and endorsed researchers (see Fig 1). Note that the levels were defined in a progressively cumulative manner. Researchers who belonged to the Record Manager level had to maintain their profile, but they also did not engage in the other two activities: answering questions or endorsing other researchers. On the other hand, researchers who belonged to the Community Member level had to engage in either of those two activities (i.e., answering questions or endorsing researchers) in addition to maintaining their profile.
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other
| 99.9 |
In the qualitative study, we did not identify any participants acting as Leaders as defined in Preece and Shneiderman’s framework, referring to those who promote participation, mentor novices, and establish community norms and policies. This can be explained by the current design of RIMSs, which do not support that level of participation. In contrast to Wikipedia and other open social knowledge-curation systems, most of the current RIMSs do not enable community self-governance and self-moderation. Furthermore, although researchers may contribute to a RIMS community by performing other activities (e.g., commenting on or reviewing papers uploaded to the RIMS), we used the tasks of answering questions from other researchers and endorsing other researchers for their expertise to differentiate between the Record Manager and Community Member levels. This decision was based on findings from the qualitative study. Researchers most frequently performed the community-level tasks of endorsing others for their expertise and answering questions .
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study
| 99.5 |
The present study also examined the relationships among researchers’ characteristics and each of the three activities. When the binary logistic models of participants’ seniority, discipline, frequency of RIMS use, and number of publications were regressed on whether the participants endorsed other researchers for their expertise, we found that graduate students and postdocs had higher odds of making endorsements than did full professors (χ2 = 31.29, p = 0.0005, pseudo R2 = 0.08; z > 2.40, p < 0.02). Postdocs also had higher odds of making endorsements than did associate professors (z = 2.07, p = 0.04). In addition, an increase in the number of publications and the frequency of RIMS use increased the odds of researchers endorsing others for their expertise (z > 1.90, p < 0.05; see Fig 1). No significant differences were found among field of study categories on the odds of endorsing other members for their expertise. Results from the regression analysis for the question-answering and profile-maintenance activities were not statistically significant.
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study
| 100.0 |
One hundred thirty-eight participants in the survey were categorized as Readers. More than a half of the respondents in the graduate student group were Readers, whereas the proportion of Readers was smallest in the assistant professor group (see Table 2). Concerning the distribution of Readers by field of study, 38% of members of the Humanities category were classified as Readers, the largest proportion compared with other disciplines. The Life Sciences had the smallest proportion (24%; see Table 3). The median number of publications for Readers was 10, and the mean frequency of RIMS use was 3.86. The frequency of RIMS use was measured on a 5-level scale ranging from Don’t use at all to Use several times a day.
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study
| 99.94 |
One hundred forty-eight participants were categorized as Record Managers. Compared with the other seniority categories, the assistant professor category made up the largest proportion of Record Managers. The graduate student category had the smallest proportion (see Table 2). The Physical Sciences category had the largest share of participants (41%) classified as Record Managers, larger than for any of the other discipline categories (see Table 3). The median number of publications for Record Managers was 20, and the mean frequency of RIMS use was 4.0.
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other
| 97.94 |
The Community Members category comprised 126 participants. In the postdoc category, 44% of the members were categorized as Community Members, the largest proportion compared with any of the other seniority categories. The graduate student category had the smallest proportion of members categorized as Community Members relative to the other seniority categories (see Table 2). According to field of study, the share of Community Members was largest in the Life Sciences category (47%) and smallest in the Humanities category (24%; see Table 3). The median number of publications for Community Members was 20, and the mean frequency of RIMS use was 4.4.
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study
| 100.0 |
To examine pairwise relationships among the participation levels, we regressed seniority level, field of study, number of publications, and frequency of RIMS use on participation level by using a multinomial logistic regression. The analysis revealed several significant relationships (model fit likelihood ratio: χ2 = 76.99; p < 0.0001; pseudo R2 = 0.09). When the Readers level was chosen as the baseline for participation level, switching from the assistant professor to any other seniority category decreased the odds of a researcher being a Record Manager (z < –2, p < 0.04). The other pairwise relationships among seniority categories were not statistically significant (see Fig 2).
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study
| 100.0 |
When Readers were compared with Community Members, postdocs and assistant professors had greater odds of being Community Members than did full professors (z > 3.75, p < 0.001), associate professors (z > 2.60, p < 0.01), or graduate students (z > 2.10, p < 0.04). Pairwise relationships between the other seniority categories were not statistically significant. Furthermore, an increase in the number of publications and frequency of RIMS use increased the odds of a researcher being a Community Member rather than a Reader (z > 3, p < 0.003; see Fig 2). Finally, switching from Engineering to Life Sciences increased the odds of a researcher becoming a Community Member rather than a Reader (z = 2.20, p = 0.03).
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study
| 99.94 |
Next, the analysis used the Record Managers level as the baseline for the dependent variable (i.e., participation level) in the regression model. Results showed that switching from the full professor category to the graduate student, postdoc, or assistant professor category increased the odds of a researcher being a Community Member rather than a Record Manager (z > 2.10, p < 0.04). Likewise, switching from associate professor and assistant professor to postdoc increased the odds of a research being a Community Member rather than a Record Manager (z > 2.10, p < 0.4).). An increase in the number of publications and frequency of use also increased the odds of a researcher being a Community Member rather than a Record Manager (z > 2.20 p < 0.03; see Fig 2). Only one statistically significant relationship was found among discipline pairs. Switching from Physical Sciences to Life Sciences increased the odds of a researcher being a Community Member (z = 2.49; p = 0.02).
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study
| 100.0 |
The three participation levels were based on whether a researcher had completed the following three activities: maintained a RIMS profile, answered questions, and endorsed researchers (see Fig 1). We examined the motivations researchers might have for completing each of the three activities and how they prioritized those motivations. To identify researchers’ motivations for each activity, we presented questions consisting of multiple motivation or attitude statements and asked them to indicate their agreement with each statement on a 7-point Likert scale ranging from strongly agree to strongly disagree. The study used a dimension reduction technique, factor analysis, to identify their underlying motivational structures for each of the three activities. The identified factors and factor-based models were then used to develop factor-based summated scales of motivations. That is, each scale was composed of the question items that significantly loaded on a factor. Finally, ordered logistic regression was used to identify researchers’ value structure or priorities for the motivation scales for each of the activities.
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study
| 100.0 |
Two hundred eighty-one participants indicated that they maintained a profile in a RIMS. The participants were given a closed-ended question consisting of 21 items to identify their reasons for engaging in the profile maintenance activities. Next, we applied a factor analysis with principal components analysis (PCA) to participants’ responses to extract the underlying factors. The component factor matrix was rotated using the Varimax rotation algorithm with Kaiser normalization. A scree plot suggested selecting the first seven factors. Factor loadings of 0.40 and above were identified as significant based on the total number of cases. Variables cross-loaded on more than one factor were removed from the model one by one, and the loadings were recalculated until no such variable was found. The resultant version of the model consisted of 18 variables and 6 factors. Results of a measurement systems analysis (MSA) indicated that each of the variables was higher than 0.59, with the overall MSA equal to 0.75 and the Bartlett test of sphericity significant at the 0.0001 level. The model captured 69% of the total variance of the data.
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study
| 100.0 |
The study used the extracted factor model to develop six summated scales. The scales were calculated as the mean values of the variables that significantly loaded on a factor. The authors evaluated the internal consistency of the factor scale with Cronbach’s alpha. The alpha values of the scales were greater than 0.70, except for the Support Evaluation scale (see Table 4). Although the alpha value of the Support Evaluation scale was below the generally accepted lower limit of 0.70, it is still considered acceptable for exploratory research and was retained in the analysis with the clear understanding that this scale would need further development.
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study
| 100.0 |
The ordered logistic analysis of the scales regressed on their values showed that Share Scholarship had significantly higher ratings than did the rest of the scales, followed by Improve Status and Enjoyment. External Pressure had the lowest ratings (see Table 4).
|
study
| 99.9 |
The Kruskal–Wallis omnibus test of the scales on seniority groups revealed significant differences for the External Pressure, Enjoyment, and Support Evaluation scales (χ2 = 14.07, p = 0.007; χ2 = 20.08, p = 0.001; χ2 = 45.37, p = 0.001). The Dunn–Bonferroni tests of post hoc pairwise comparisons indicated that postdocs had significantly higher mean ranks for External Pressure than did full and associate professors. Graduate students, postdocs, and assistant professors had significantly higher mean ranks for the Enjoyment scale than did full professors. Likewise, graduate students, postdocs, and assistant professors had significantly higher mean ranks for the Support Evaluation scale than did associate and full professors (see Fig 3).
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study
| 100.0 |
Pairwise comparison of seniority groups for (a) External Pressure, (b) Enjoyment, and (c) Support Evaluation. Numbers in parentheses indicate the mean ranks of seniority groups. An edge between the pair of nodes on the graph indicates a statistically significant difference between seniority groups for the motivation scale (p < 0.05).
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other
| 95.1 |
The Kruskal–Wallis omnibus test of the scales on discipline categories revealed significant differences for the Quality of Recommendations and Support Evaluation scales (χ2 = 15.46, p = 0.004; χ2 = 13.65, p = 0.009). Dunn–Bonferroni tests of post hoc pairwise comparisons in particular indicated that researchers from the Engineering category had significantly higher mean ranks for the Quality of Recommendations scale scores than did researchers from the Social Sciences category (p = 0.002; see Fig 4). In addition, researchers from the Engineering category had significantly higher mean ranks for the Support Evaluation scale than did researchers from the Humanities category (p = 0.036; see Fig 5).
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study
| 100.0 |
Next, participants were asked whether the RIMS they used supported asking and answering questions, and whether they answered questions received from other researchers. One hundred fifty-five participants indicated that at least one RIMS they used supported question answering. Fifty-five participants revealed that they answered questions from other members of a RIMS. To identify the underlying structure of researchers’ motivations for answering other members’ questions, the study used a factor analysis. The analysis treated each motivation question item as a variable. The initial model included 16 variables. The study used PCA to extract factors. The component factor matrix was rotated using the Varimax rotation algorithm with Kaiser normalization. A scree plot suggested selecting the first four eigenvalues. Factor loadings of 0.75 and above were identified as significant based on the total number of cases. Variables that had an MSA lower than 0.5 or that were cross-loaded on more than one factor were removed from the model one by one, and the loadings were recalculated until no such variable was found. The resultant version of the model consisted of 10 variables and 4 factors. The MSA of each of the variables was higher than 0.5, with the overall MSA equal to 0.57 and the Bartlett test of sphericity significant at the 0.0001 level. The model captured 80% of the total variance of the data.
|
study
| 100.0 |
The four factors were labeled as follows based on the significant loadings: Build Community Ties, Enjoyment, Expertise, and External Pressure. We used the extracted factor model to develop four summated scales. The scales were calculated as the mean values of variables with significant loadings on a factor. The authors evaluated the internal consistency of the factor scale with Cronbach’s alpha. The alpha values of the scales were greater than 0.85, except for the External Pressure scale (see Table 5). Although the alpha value of the External Pressure scale was below the generally accepted lower limit of 0.70, it was retained in the analysis for theoretical purposes.
|
study
| 100.0 |
The ordered logistic analysis of the scales regressed on their values showed that Expertise had significantly higher ratings than did the rest of the scales, followed by Build Community Ties and Enjoyment. The External Pressure scale was rated the lowest and was below the neutral value of the scale (see Table 5).
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study
| 99.94 |
The Kruskal–Wallis omnibus test of the question-answering motivation scales on seniority groups revealed significant differences for only Build Community Ties (χ2 = 11.57, p = 0.02). The Dunn–Bonferroni tests of post hoc pairwise comparisons indicated that graduate students had significantly higher mean ranks for the Build Community Ties scale than did full professors (see Fig 6). A similar analysis of the scales on discipline did not find significant differences.
|
study
| 100.0 |
Two hundred thirty-nine participants indicated that at least one RIMS they used allowed them to endorse other researchers for their expertise. One hundred fifteen of them revealed that they endorsed other RIMS users for their expertise. To identify the underlying structure of researchers’ motivations to endorse other researchers, we used a factor analysis in which each item in the survey question was treated as a variable. The initial model included 10 variables. Principal components analysis was used to extract factors. The component factor matrix was rotated using the Varimax rotation algorithm with Kaiser normalization. A scree plot suggested selecting the first three eigenvalues. Factor loadings of 0.55 and greater were identified as significant based on the total number of cases. Variables with an MSA below 0.5 or that loaded significantly on more than one factor were removed one by one, and factor loadings were recalculated. The resultant version of the model consisted of 8 variables and 3 factors. The MSA of each of the variables was higher than 0.5, with the overall MSA equal to 0.72 and the Bartlett test of sphericity significant at the 0.0001 level. The model captured 82% of the total variance of the data.
|
study
| 100.0 |
The extracted factor model was used to develop three summated scales: Expertise, Enjoyment, and Build Community Ties. The scales were calculated as the average values of variables with significant loadings on a factor. We evaluated the internal consistency of the factor scale with Cronbach’s alpha, and the alpha values of the scales were greater than 0.80 (see Table 6).
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study
| 100.0 |
Pairwise comparisons of the scales showed that Expertise had significantly higher ratings than did the rest of the scales. Build Community Ties was rated the lowest, although its average value was still above the neutral level of the evaluation scale used for the survey question (i.e., 4; see Table 6).
|
study
| 99.44 |
The Kruskal–Wallis omnibus test of the endorsement motivation scales on seniority groups revealed significant differences for the Expertise scale (χ2 = 11.57, p = 0.02). The Dunn–Bonferroni tests of post hoc pairwise comparisons indicated that postdocs had significantly higher mean ranks for that scale than did assistant professors (see Fig 7). A similar analysis of the scales by discipline did not reveal significant differences.
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study
| 100.0 |
The first research question examined how researchers participated in RIMSs. We categorized researchers’ participation in RIMSs into three levels: Readers, Record Managers, and Community Members. Graduate students had the greatest share of Readers, whereas assistant professors had the greatest share of Record Managers and postdocs had the greatest share of Community Members (see Table 2). Furthermore, assistant professors had significantly higher odds than did other seniority groups of being Record Managers rather than Readers. Postdocs and assistant professors had significantly higher odds than did the rest of the seniority groups of being Community Members rather than Readers. Likewise, postdocs had a higher probability than did the other seniority categories, except for students, of being Community Members rather than Record Managers (see Fig 8). Thus, overall, assistant professors and postdocs were more engaged in RIMSs as Record Managers and Community Members than were other seniority groups, and postdocs exhibited higher odds than did assistant professors of being Community Members rather than Record Managers. That is, although assistant professors were more focused only on maintaining their RIMS profiles, postdocs were more willing than assistant professors to answer questions or endorse others, in addition to maintaining their RIMS profiles. Finally, as expected, as the frequency of RIMS use and the number of publications increased, the odds of being more engaged in a RIMS as a Record Manager or a Community Member increased (see Fig 2). These findings can be explained by the fact that assistant professors undergo the most frequent formal evaluation as tenure-track faculty and hence have a greater incentive to maintain complete and accurate RIMS profiles. Postdocs, on the other hand, have not yet secured a tenure track position and may be more motivated to cultivate relationships with other members of RIMSs. They may also wish to enhance their visibility though various types of contributions that may not count in the formal models of evaluation applied to assistant professors.
|
study
| 99.94 |
Numbers represent the ranking of a scale relative to the other scales. More than one number assigned to a motivation scale (e.g., 2-3-4) means that the scale shares the rankings indicated by these numbers with other scales for the activity. St. denotes Student; Pst. denotes Postdoc; Assi.P. denotes Assistant Professor; Asso.P denotes Associate Professor, and F.P. denotes Full Professor.
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other
| 99.94 |
Regarding discipline, the Humanities and Engineering had the greatest shares categorized as Readers and Record Managers. The Physical Sciences had the greatest share categorized as Record Managers, and Community Members made up the largest share of the Life Sciences category (see Table 3). The analysis also showed that life scientists exhibited a significantly higher propensity than did engineers of being Community Members rather than Readers. Furthermore, life scientists had significantly higher odds than did physical scientists of being Community Members rather than Record Managers. These findings about life scientists seem to contradict the findings by Mas-Bleda and colleagues that, at European institutions in general, an online presence in a RIMS is lower in the life sciences than in other disciplines. Our study showed that as Community Members, life scientists were one of the most highly involved disciplinary categories.
|
study
| 99.94 |
The examination of individual activities showed that 55 participants (13%) answered questions from other members of a RIMS, whereas 281 researchers (68%) revealed that they only maintained their RIMS profiles, and 115 researchers (28%) endorsed other members for their expertise. Thus, substantially higher numbers of researchers were willing to endorse other members and maintain their profiles than to answer questions. This result could be explained by the higher cost of answering questions relative to endorsing researchers for their expertise. Another explanation could be that RIMSs might give researchers more opportunities to make endorsements than to answer questions that researchers find interesting and relevant to their research interests. As one participant noted, “The [system’s] UI design encourages [making endorsements]—makes it quick and convenient.” (S71)
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other
| 99.7 |
Researchers who used RIMSs more often or who had high numbers of publications were more likely to endorse other researchers for their expertise. In addition, postdocs showed greater willingness to endorse other members than did full and associate professors (see Fig 1). This result suggests that junior researchers who might not have as many high-impact publications as senior researchers might assign a higher value to alternative indicators of quality, such as peer endorsements. One postdoctoral participant commented,
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other
| 99.9 |
The second research question investigated researchers’ motivations to participate in RIMSs. Table 7 provides a summary of the motivation scales developed for the three activities. The numbers indicate the ranking of each motivation scale relative to the other motivation scales for an activity. The question-answering and endorsement activities had similar motivation scales. Both had similar sets of motivation scales and were ranked similarly, although the question-answering activity had one extra scale (External Pressure). Expertise was the top-rated scale for question-answering and endorsement activities. In addition, Enjoyment was common for all three activities and shared the second highest ranking. Build Community Ties shared the second highest ranking with Enjoyment for the question-answering and endorsement activities. Thus, Expertise, Enjoyment, and Build Community Ties were rated higher for the question-answering and endorsement activities compared with other motivations. These motivations can be categorized as intrinsic. Self-determination theory postulates that for a person to be intrinsically motivated, the person must feel competent, inherently autonomous, and related to others and must find the overall activity she or he is performing interesting or pleasant .
|
study
| 99.9 |
Analysis of the motivations for RIMS profile maintenance identified six motivation scales. The Share Scholarship motivation was ranked significantly higher than the rest of the scales. Research publications and data are the main products of a research activity, and they determine researchers’ standings in their home institutions and peer communities, their promotion, and their tenure . Hence, it was not surprising that the desire to make authored content more findable and accessible was ranked the highest. It is noteworthy that this motivation scale showed no statistically significant difference among different seniority groups.
|
other
| 99.9 |
Quality of Recommendations and External Pressure were ranked significantly lower than the other scales and lower than the neutral value of the Likert scale used in the related survey question. This result suggests that researchers may not consider the quality of recommendations received from RIMSs or social pressure from colleagues or supervisors central to their decision making regarding whether to maintain their RIMS profile. Still, a few participants revealed in their comments that they maintained their RIMS profile because their colleagues did. As one of them explained, she did not want “to appear as an outdated researcher.” It is interesting to note that Enjoyment was evaluated higher than Support Evaluation and above the neutral value. Although Share Scholarship can be linked to external motivation, such as improving the chances of researchers’ having their scholarship cited, some may enjoy the activity. This could relate to the pleasure received from “announcing [their] achievements among peers and friends” (S378) or from enhanced self-worth and satisfaction after providing their peers and the public open access to their scholarship. One participant stated,
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other
| 99.5 |
I think a lot of it is self-esteem in the profession and wanting to be generous with the scholarship that I’ve worked on and to make it available quite widely. I had a mentor in grad school who really urged us to do everything in the spirit of intellectual generosity, and I’ve tried to practice that whenever possible. I think there are certain [RIM] systems that let you practice intellectual generosity and maybe in a small way. (S13)
|
other
| 99.94 |
Another participant who specialized in South Asian Studies stated that she wanted to “provide open access [to her scholarship] to scholars in the global south” (S70). Hence, in those instances, sharing scholarship could be motivated intrinsically or by integrated regulations. Self-determination theory defines integrated regulation as the type of external motivation that occurs when the objectives of a regulation are fully integrated and aligned with the values and beliefs of the self . These findings also echo the literature on participation in FOSS projects in which altruism and community identification were identified as motivations to contribute .
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other
| 99.9 |
Pairwise comparisons of seniority groups for the Support Evaluation scale showed that graduate students, postdocs, and assistant professors had significantly higher ratings for this scale than did full and associate professors. Graduate students, postdocs, and assistant professors also rated the Enjoyment scale significantly higher than did full professors (see Fig 3). These results can be explained by the fact that most full and associate professors have tenure, and hence have less pressure to facilitate their own evaluations.
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other
| 98.1 |
Pairwise comparisons of discipline categories found engineering researchers to have higher ratings for the Support Evaluation than did humanities researchers. This result could be an indicator of the differences in the scholarly communication and evaluation models used by the two disciplines. Researchers in the humanities favor publishing books and monographs and their evaluation models are often book based, whereas those in engineering fields of study use scholarly communication and evaluation models based more on conference and journal papers . Traditionally, books and monographs have received scant coverage in the index databases used in bibliographic analysis of research impact. Hence, compared with the engineering field, the humanities field may rely less on citation-based metrics when evaluating research output and researchers for impact . Furthermore, providing open access to books and monographs has been challenging . Thus, one would expect that the humanities field would rely less than the engineering field on the evaluation models of research impact and the services provided by RIMSs. Similarly, engineers had higher ratings for the Quality of Recommendations scale than did social scientists. One can theorize that researchers in the social sciences might rely more on other means of communication and information sharing (e.g., personal networks) to stay current in their literature than those in engineering. These findings can be used to prioritize RIMS evaluation and recommendation services by discipline. In addition, further research could shed light on alternative models and the means of evaluation and literature monitoring that these disciplines use and could inform the design of RIMS services.
|
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| 99.9 |
Postdocs rated the External Pressure scale higher than did full and associate professors. This too could be explained by postdocs, as junior researchers, being more dependent on and influenced by their advisors and supervisors, including receiving suggestions on how to promote their scholarship by using RIMSs. On the other hand, senior researchers, by advising their junior colleagues to maintain their profiles, may be motivating themselves to lead by example. One full professor made the following observation:
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other
| 99.94 |
The analysis of motivations for the question-answering activity identified four scales (see Table 5). Expertise had significantly higher ratings than did the rest of the scales. Answering questions from other researchers was the most cognitively expensive activity among the three activities used in this study to define the RIMS participation levels. Successful completion of the question-answering activity requires information systems to successfully match questions with the competence respondents have. Ardichvili and colleagues found that the fear of providing an inaccurate answer and, as a result, losing face among peers was one of the main barriers to knowledge sharing in an online community of practice. Research communities are competence-based communities that assign the highest priority to the accuracy and reliability of information . Hence, it is not surprising that participants rated feeling competent as the highest motivation for the question-answering activity. It is noteworthy that External Pressure again was rated the lowest and below the neutral value on the Likert scale for the survey question (i.e., 4). Researchers do not appear to be very receptive to prompts received from RIMSs to answer questions posted by other members. One participant noted,
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| 100.0 |
Enjoyment and Build Community Ties were rated the second highest. No statistically significant difference was found between these two intrinsic motivation scales. Thus, in addition to having the necessary expertise, a researcher might also need to find the question intellectually satisfying and enjoyable to answer, or feel related to or caring for the person who asked the question, or both. One participant explained,
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other
| 99.9 |
Another participant noted that she used a peer’s question “to initiate a higher level discussion for the topic” (S271). These responses echo the findings from the literature that answering a challenging question can provide enjoyment and satisfaction by creating new knowledge, helping others, or simply feeling competent . Furthermore, according to the theory of flow, people feel more satisfied when the challenges of tasks they perform match the competence and skill levels they have .
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other
| 99.9 |
Pairwise comparisons of the seniority groups for the question-answering motivation scales revealed no significant differences, except for the Build Community Ties scale. Graduate students had the highest mean rank compared with the rest of the seniority groups and had a significantly higher mean rank than did full professors (see Fig 4). One might suggest that senior researchers are already a part of the “invisible college” and have accrued significant social capital . Hence, senior researchers may be less motivated than graduate students to forge new community ties through RIMSs.
|
study
| 83.94 |
The analysis of motivations for the endorsement activity identified only three scales (see Table 6). As with the question-answering activity, the Expertise scale was rated significantly higher than the Enjoyment and Build Community Ties scales. Like the question-answering activity, no statistically significant difference was found between the Enjoyment and Build Community Ties scales. The Kruskal–Wallis test of the scales on seniority groups found significant differences only for Expertise. Postdocs had the highest mean rank for the scale, significantly higher than that for assistant professors (see Fig 5). This last finding is quite intriguing and warrants further investigation. One can only suggest that postdoctoral appointments are typically research-only appointments. On the other hand, in addition to conducting research, assistant professors might be responsible for and have a need to promote their own graduate students and postdoctoral researchers, as well as to build and maintain ties with other colleagues at their institutions or in a greater research community to receive promotion and tenure. Hence, assistant professors may prioritize other motivations, such as group loyalty, when making endorsements. Rashid and colleagues showed that members of an online information system were more willing to make contributions when those contributions benefited smaller groups they were part of rather than the general community. One full professor noted that he made endorsements “to support [his] junior faculty, colleagues, and graduate students” (S9).
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study
| 100.0 |
This study examined how researchers participated in RIMSs and their motivations for participation. Profile maintenance, question-answering, and endorsement activities were used to define three cumulatively increasing levels of participation: Readers, Record Managers, and Community Members. Junior researchers were more engaged in RIMSs than were senior researchers. Postdocs had significantly higher odds of endorsing other researchers for skills than did full and associate professors, and they were more likely to be categorized as Community Members. Assistant professors showed a significantly higher propensity to be Record Managers than did any of the other seniority categories. Finally, researchers from the life sciences showed a significantly higher propensity to be Community Members than Readers and Record Managers when compared with researchers from Engineering and the Physical Sciences, respectively.
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study
| 99.5 |
The study revealed that when performing activities, researchers were motivated by the desire to share scholarship, feel competent, feel a sense of enjoyment, improve their status, and build ties with other members of the community. Moreover, when researchers performed activities that directly benefited other members of a RIMS, they assigned higher priorities to intrinsic motivations, such as perceived self-efficacy, enjoyment, and building community ties. Furthermore, researchers at different stages of their academic careers and from different disciplines ranked some RIM motivations differently. For the RIMS profile maintenance activity, junior researchers enjoyed and were motivated by the desire to support their evaluations more than were senior researchers. In addition, postdocs were more influenced by external pressure than were senior researchers. Regarding discipline, researchers from engineering had higher priorities for the Support Evaluation and Quality of Recommendations scales than did humanities and social sciences researchers, respectively. For the question-answering activity, students were more motivated by the desire to establish community ties than were full professors.
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other
| 85.2 |
The general model of research participation in RIMSs; the relationships among RIMS activities; the motivation scales for the activities; and activity, seniority, and discipline-specific priorities for the motivations developed in this study provide the foundation for a framework of researcher participation in RIMSs (see Fig 8). The framework can be used by RIMS and institutional repositories to develop tools and design mechanisms to increase researchers’ engagement in RIMSs. The framework can be used to develop motivation measurement instruments, member profile templates, and communication strategies tailored to the different levels of researchers’ engagement, career status, and discipline. Future research will extend the framework by adding models of researchers’ value structure and priorities for RIMS metadata and services.
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other
| 99.4 |
The study has limitations. The Cronbach’s alpha values of 2 of the 13 motivation scales developed in this study were below the generally accepted lower limit of 0.70. In this study, we retained these two scales (Support Evaluation and External Pressure) in the analyses for theoretical purposes, with a clear understanding that these scales would need further research and development.
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study
| 100.0 |
Historically, natural products have inspired the development of many pharmaceuticals and agrochemicals, which, have in turn, played an important role in improving human and animal health and agricultural productivity, enhancing the quality of life for communities across the globe . One of the defining characteristics of natural products is their structure diversity, which can encompass complex carbocyclic and heterocyclic scaffolds, annotated with a wide array of functional groups and stereochemical features. As such, even a limited set of biosynthetic precursors can deliver remarkable chemical diversity. Illustrative of this phenomenon are bromophenols from marine red algae (Rhodophyta) . For example, the red alga Symphyocladia latiuscula (Harvey) Yamada has been reported to produce a diverse array of bromophenols elaborated by sulfoxides, sulphones, sulfates, glutamines, pyrrolidin-2-ones, ureas, diketopiperazines, and aconitic acids, with biological properties spanning antibacterial , antifungal , antiviral , anticancer , free radical scavenging , aldose reductase inhibitory , and Taq DNA polymerase inhibitory activities . S. latiuscula bromophenols typically contain at least one 2,3,6-tribromo-4,5-dihydroxybenzyl moiety, as consistent with a highly conserved biosynthetic pathway. This report described our efforts to further elaborate the chemical diversity of S. latiuscula.
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| 99.94 |
The EtOAc extract of a Chinese collection of S. latiuscula was concentrated in vacuo and subjected to a sequence of normal, reversed phase, and gel chromatography, with HPLC-MS analysis being used to prioritize fractions of interest. Following this strategy, we isolated and characterized six citric acid derived natural products, aconitates A–F (1–6), together with two known and ten new polybrominated phenol adducts, symphyocladins C/D (7a/b), and symphyocladins H–Q (8a/b, 9a/b and 10–15), respectively (Figure 1). A spectroscopic analysis approach (see Table 1, Table 2, Table 3, Table 4 and Table 5) to the structure elucidation of all of these metabolites is summarized below.
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| 100.0 |
HRESI(+)MS measurements confirmed that 1 (C7H8O6, Δmmu +0.2), 2 (C7H8O6, Δmmu +0.1) and 3 (C7H8O6, Δmmu +0.1) were isomeric, while analysis of the one-dimensional (1D) and two-dimensional (2D) NMR (methanol-d4) data (Figures S8–S13, Tables S2 and S3) suggested they were mono methyl esters of E-aconitic acid, for which we attribute the trivial names aconitates A–C. Assignment of E ∆3,4 configurations were inferred from diagnostic chemical shifts for H-4 and C-2 in 1 (δH 6.92; δC 33.8), 2 (δH 6.89; δC 33.9), and 3 (δH 6.91; δC 33.9), when compared to the authentic standards for E (δH 6.90; δC 33.8) and Z (δH 6.26; δC 40.2) aconitic acid (Figures S1–S7, Table S1). HMBC correlations permitted assignment of the methyl ester regiochemistry across 1–3 with correlations from (i) the OMe (δH 3.67) and H2-2 (δH 3.89) to C-1 (δC 172.7) confirming a C-1 CO2Me in aconitate A (1), (ii) the OMe (δH 3.81) and H2-2 (δH 3.89) to C-6 (δC 168.4) confirming a C-6 CO2Me in aconitate B (2), and (iii) the OMe (δH 3.77) and H-4 (δH 6.91) to C-5 (δC 167.5) confirming a C-5 CO2Me in aconitate C (3) (Figure 2).
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study
| 100.0 |
HRESI(+)MS measurements suggested that 4 (C8H10O6, Δmmu +0.2) and 5 (C8H10O6, Δmmu +0.2) were isomeric dimethyl esters, and 6 (C9H12O6, Δmmu +0.1) was a trimethyl ester, of aconitic acid. Analysis of the NMR (methanol-d4) data for 4–6 (Figures S14–S19, Tables S3 and S4) confirmed these assignments, with E ∆3,4 configurations being inferred from diagnostic chemical shifts for H-4 and C-2 in aconitate D (4) (δH 6.91; δC 33.8), aconitate E (5) (δH 6.92; δC 33.9) and aconitate F (6) (δH 6.92; δC 33.8), and HMBC correlations permitting the assignment of the dimethyl ester regiochemistry across 4 and 5. For example, correlations from an OMe (δH 3.67) and H2-2 (δH 3.91) to C-1 (δC 172.5), and from an OMe (δH 3.80) and H2-2 to C-6 (δC 168.2), confirmed the presence of C-1 CO2Me and C-6 CO2Me moieties in 4, whereas correlations from an OMe (δH 3.67) and H2-2 (δH 3.91) to C-1 (δC 172.5), and from an OMe (δH 3.76) and H-4 (δH 6.92) to C-5 (δC 167.5), confirmed C-1 CO2Me and C-5 CO2Me moieties in 5 (Figure 2).
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study
| 100.0 |
HRESI(+)MS measurements confirmed that 7a/b (C14H11Br3O8, Δmmu +0.5) and 8a/b (C14H11Br3O8, ∆mmu +0.4) were isomeric, and suggested that 9a/b (C15H13Br3O8, Δmmu +0.4) and 10 (C15H13Br3O8, Δmmu +0.5) were CH2 homologues, and 11 (C17H17Br3O8, Δmmu +0.6) was a CH2CH2 homologue of 7a/b and 8a/b. Analysis of the NMR (acetone-d6) data for 7a/b (Figures S20 and S21, Table 1, Table 2 and Table S5) confirmed them as symphyocladins C/D, first reported in 2012 from S. latiuscula as an inseparable mixture of Z/E ∆2,7′ isomers . Analysis of the NMR (methanol-d4) data for symphyocladins H/I (8a/b) (Figures S22–S27, Table 1, Table 2 and Table S6) revealed ∆2,3 and C-5 CO2Me moieties, as evidenced by diagnostic HMBC correlations (Figure 3). Significantly, these data also revealed an interconverting mixture of E/Z ∆2,3 isomers, in which the minor Z isomer, symphyocladin H (8a), as evidenced by a ROESY correlation between H2-4 and H2-7′ (Figure 3), was in equilibrium with the major E isomer, symphyocladin I (8b). Further analysis of this NMR data revealed chemical shift differences diagnostic for ∆2,3 geometric isomers; H2-4 (E δH 3.65, δC 35.0; Z δH 3.19, δC 29.5), C-1 (E δC 170.3; Z δC 166.5), C-3 (E δC 127.4; Z δC 137.8), and C-5 CO2Me (E δH 3.71; Z δH 3.51). Remarkably, the NMR (acetonitrile-d3) data for 8a/b revealed a single Z isomer 8a, as evidenced by simplified spectra, a ROESY correlation between H2-4 and H2-7′, and diagnostic chemical shifts (Figures S28 and S29, Table S7). We speculate that in aprotic solvents (i.e., acetonitrile-d3), hydrogen bonding between adjacent CO2H moieties exclusively favors the lower energy Z ∆2,3 isomer. By contrast, in protic solvents (i.e., methanol-d4), the disruption of this hydrogen bonding favor equilibration to an E/Z ∆2,3 mixture dominated by the less sterically constrained E isomer. This observation highlights the critical importance that NMR solvents can play in the analysis and structure elucidation of natural products.
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study
| 100.0 |
Analysis of the NMR (DMSO-d6) data for symphyocladins J/K (9a/b) (Figures S30 and S31, Table 1, Table 2 and Table S8) identified an inseparable mixture of C-6 CO2Me homologues of 7a/b and 8a/b, as evidenced by spectroscopic comparisons and diagnostic HMBC correlations from the additional CO2Me resonances to C-6 (Figure 3). In this instance, as hydrogen bonding does not stabilize double bond isomers, the Z/E mixture prevails even in an aprotic solvent (i.e., DMSO-d6). Analysis of the NMR (acetone-d6) data for symphyocladin L (10) (Figures S32 and S33, Table 3, Table 5 and Table S9) revealed a ∆3,4 isomer and 1-CO2Me homologue of 7a/b and 8a/b, as evidenced by COSY correlations between H-2 and H2-7′, and diagnostic HMBC correlations positioning both C-1 CO2Me and C-5 CO2Me (Figure 3). The structure of 10 inclusive of an E ∆3,4 configuration and its racemic nature were confirmed by single crystal X-ray analysis with the compound crystallizing in a centrosymmetric space group (Figures S34 and S35). Analysis of the NMR (methanol-d4) data for symphyocladin M (11) (Figures S36 and S37, Table 3, Table 5 and Table S10) revealed it as a C-6 CO2Et homologue of 10, as evidenced by spectroscopic comparisons and an HMBC correlation from the CO2Et moiety to C-6.
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study
| 100.0 |
HRESI(+)MS measurements suggested that 12 (C13H11Br3O6, Δmmu +0.5) was a decarboxy analogue of 7a/b and 8a/b; 13 (C14H13Br3O7, Δmmu +0.5) was a dihydro oxidized methyl ester of 12; 14 (C13H11Br3O6, Δmmu +0.5) was a decarboxymethyl analogue of 10; and, 15 (C14H13Br3O6, Δmmu +0.5) was a CH2 homologue of 14. Comparison of the NMR (methanol-d4) data for symphyocladin N (12) (Figures S38 and S39, Table 4, Table 5 and Table S11) with that for 8a/b revealed the key difference as replacement of the C-1 CO2H moiety in 8a/b with an H-2 olefinic methine (δH 6.79) coupled to H2-7′ (δH 4.05). The presence of a C-5 CO2Me moiety in 12 was evident from an HMBC correlation from the OMe (δH 3.66) to C-5 (δC 171.3), while an E Δ2,3 configuration was confirmed by a ROESY correlation between H2-4 (δH 3.60) and H2-7′ (Figure 4). Analysis of the NMR (methanol-d4) data for symphyocladin O (13) (Figures S40 and S41, Table 4, Table 5, and Table S12) revealed it to be a saturated oxidized analogue of 12, as evidenced by COSY correlations between a diastereotopic H2-2 (δH 3.35/3.27), through H-3 (δH 3.34) to a diastereotopic H2-4 (δH 2.86/2.73). Likewise, replacement of the C-7′ sp3 methylene in 12 (δC 39.0) with a carbonyl resonance in 13 (δC 202.2) was evidence of a 7-oxo moiety. Diagnostic HMBC correlations also established the presence of incorporated C-5 CO2Me (δH 3.68) and C-6 CO2Me (δH 3.71) moieties (see Figure 3).
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study
| 100.0 |
Comparison of the NMR (methanol-d4) data for symphyocladin P (14) (Figures S42 and S43, Table 4, Table 5 and Table S13) with that for 10 revealed the key difference as replacement of the C-5 CO2Me moiety in 10 with a diastereotopic H2-4 olefinic methylene (δH 6.22/5.44). Comparison of the NMR (acetone-d6) data for symphyocladin Q (15) (Figures S44 and S45, Table 4, Table 5 and Table S14) with that for 14 revealed the key difference as an additional resonance, attributed to a C-6 CO2Me moiety (δH 3.71). Structure assignments for 14 and 15 were further supported by diagnostic 2D NMR correlations (Figure 4).
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study
| 100.0 |
Structural similarities across 1–15 suggest a highly conserved biosynthesis. Building on this observation, we propose a biosynthetic relationship (Figure 5), in which the aconitates A–F (1–6) are viewed as mono, di, and tri methyl esters of the precursor E-aconitic acid, itself a dehydration product of citric acid. Likewise, metabolites 7–15 can be viewed as adducts between aconitates and an intermediate quinone methide that is generated from 2,3,6-tribromo-4,5-dihydroxybenzyl alcohol, further elaborated by a combination of 1,3-hydride shifts, decarboxylations and oxidations. Although 7a/b, 9a/b, 10–11, and 13 incorporate a single chiral sp3 center, as they do not exhibit measurable optical rotations they are presumed to be racemic, as confirmed for 10 by X-ray crystallography. The absence of double bond migrations (i.e., racemization) during isolation and handling suggests that this racemic character is a function of achiral adduct addition. The proposed biosynthetic relationship informs a possible biomimetic synthesis of 7–15, although, in our hands, synthetic 2,3,6-tribromo-4,5-dihydroxybenzyl alcohol proved stable to both acid and base conditions indicative of a requirement to activate the benzyl alcohol moiety to effect dehydration and the formation of a quinone methide.
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study
| 100.0 |
General Experimental Procedures. Specific optical rotations ([α]D) were measured on a polarimeter in a 100 × 2 mm cell at 22 °C. NMR spectra were obtained on a Bruker Avance DRX600 or DRX500 spectrometers, in the solvents indicated and referenced to residual 1H and 13C signals in deuterated solvents. Electrospray ionization mass spectra (ESIMS) were acquired using an Agilent 1100 Series separations module equipped with an Agilent 1100 Series LC/MSD mass detector in both positive and negative ion modes. High-resolution ESIMS measurements were obtained on a Bruker micrOTOF mass spectrometer by direct infusion in MeCN at 3 mL/min using sodium formate clusters as an internal calibrant. HPLC was performed using an Agilent 1100 Series separations module equipped with Agilent 1100 Series diode array and/or multiple wavelength detectors and Agilent 1100 Series fraction collector, controlled using ChemStation Rev.B02.01 and Purify version A.1.2 software.
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study
| 99.94 |
Algal material. Symphyocladia latiuscula was collected on the coast of Qingdao, Shandong Province, China, in May 2004. The specimen identification was verified by Dr. Kui-Shuang Shao (Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China). A voucher specimen (No. 2004X16) was deposited at the Herbarium of the Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
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other
| 99.94 |
Extraction and isolation. The air-dried red alga Symphyocladia latiuscula (4.3 kg) was extracted with 95% EtOH at room temperature (3 × 72 h). After the solvent was removed under reduced pressure at <40 °C, a dark residue (610 g) was obtained. The residue was partitioned between EtOAc and H2O, and the EtOAc-soluble partition (320 g) was chromatographed over silica gel, eluting with a gradient of 0–100% Me2CO/petroleum ether to yield 85 fractions (F1–F85) (see Supporting Information Scheme S1 for the fractionation scheme). Fraction F54 was further fractionated over Sephadex LH-20 using CHCl3–MeOH (2:1) to afford 21 fractions.
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study
| 100.0 |
The sixth fraction from Sephadex LH-20 chromatography was fractionated on an ODS column, eluted by a stepwise gradient (0–100% MeOH/H2O) to afford 11 fractions. The third fraction was subjected to HPLC separation (Zorbax Eclipse XDB-C8, 5 μm, 250 × 9.4 mm column, 3.0 mL/min, gradient elution from 10 to 80% MeCN/H2O over 15 min, with isocratic 0.01% TFA modifier) to yield 1–6; the sixth fraction was subjected to HPLC separation (Zorbax SB-C18, 5 μm, 250 × 9.4 mm column, 3.0 mL/min, gradient elution from 30 to 75% MeCN/H2O over 14 min, with isocratic 0.01% TFA modifier) to yield 8a/b and 9a/b; and the seventh fraction was subjected to HPLC separation (Zorbax Eclipse XDB-C8, 5 μm, 250 × 9.4 mm column, 3.0 mL/min, gradient elution from 40 to 55% MeCN/H2O over 20 min, with isocratic 0.01% TFA modifier) to yield 11 and 13.
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study
| 99.94 |
The eighth fraction from Sephadex LH-20 chromatography was fractionated on an ODS column, eluted with a stepwise gradient (0–100% MeOH/H2O) to afford 11 fractions; the sixth fraction was subjected to HPLC fractionation (Zorbax SB-C18, 5 δm, 250 × 9.4 mm column, 3.0 mL/min, gradient elution from 35 to 50% MeCN/H2O over 15 min, with isocratic 0.01% TFA modifier) to yield 14; the seventh fraction was subjected to HPLC fractionation (Zorbax SB-C18, 5 μm, 250 × 9.4 mm column, 3.0 mL/min, gradient elution from 50 to 60% MeCN/H2O over 12 min, with isocratic 0.01% TFA modifier) to yield 12 and 15.
|
study
| 99.94 |
The ninth fraction from Sephadex LH-20 chromatography was fractionated on an ODS column, eluted with a stepwise gradient (0–100% MeOH/H2O) to afford 11 fractions; the third fraction was subjected to HPLC fractionation (Zorbax SB-C18, 5 μm, 250 × 9.4 mm column, 3.0 mL/min, gradient elution from 30 to 80% MeCN/H2O over 20 min, with isocratic 0.01% TFA modifier) to yield 7a/b.
|
study
| 99.94 |
X-ray crystallography. X-ray crystallographic data were collected on an Oxford Diffraction Gemini CCD diffractometer with Mo-Kα radiation (0.71073 Å) operating within the range 2 < 2θ < 50°. The sample was cooled to 190 K with an Oxford Cryosystems Desktop Cooler. Data reduction and empirical absorption corrections were performed using CrysAlisPro (Rigaku Oxford Diffraction, Yarnton, Oxfordshire, UK). The structure was solved by Direct Methods and refined with SHELX and all of the calculations and refinements were carried out by WinGX package . All non-H atoms were refined aniostropically. The thermal ellipsoid plot was produced with ORTEP and the unit cell diagram was drawn with PLATON . Crystallographic data including structure factors in CIF format have been deposited with the Cambridge Crystallographic Data Centre (CCDC 1569026).
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study
| 99.94 |
Acquired immunodeficiency syndrome (AIDS) is one of the world’s most serious public health concerns, and poses an enormous challenge to most countries, especially developing countries such as Nigeria. Nigeria carries the second heaviest burden of HIV in Africa and has an expanding population of people living with HIV/AIDS (PLWHA) (Federal Republic of Nigeria, 2012). The first HIV Sentinel Survey in Nigeria in 1991 showed a prevalence of 1.8%. Subsequent sentinel surveys produced prevalence of 3.8% (1993), 4.5% (1996), 5.4% (1999), 5.8% (2001), 5.0% (2003), 4.4% (2005), 4.6% (2008) and 4.1% (2010) (Federal Republic of Nigeria, 2012). Health care workers (HCWs) are key players in the management of HIV infection because it is through the health infrastructure that individuals can learn of their HIV status, obtain prevention education, and seek treatment and care (Kiragu et al., 2007). The attitude of HCWs influences the willingness and ability of PLWHA to access care and influences the quality of care they receive (Kermode, Holmes, Langkham, Thomas, & Gifford, 2005). Discrimination against HIV-positive patients has profound impact on the care and support required for their optimal management particularly in resource-constrained settings (Sadoh, Fawole, Sadoh, Oladimeji, & Sotiloye, 2006). Stigmatization and discrimination impact negatively on interventions and act as barriers to adherence to antiretroviral therapy among PLWHA (Omosanya, Elegbede, Agboola, Isinkaye, & Omopariola, 2013). PLWHAs in Nigeria have been found to be subject to discrimination and stigmatization in the workplace, by family and communities (Reis et al., 2005) and may also face discrimination from HCWs (Famoroti, Fernandes, & Chima, 2013; Omosanya et al., 2013). Discriminatory or unethical behavior may hinder effective prevention and treatment by discouraging individuals from being tested or seeking information on how to protect themselves and others from HIV/AIDS.
|
review
| 99.8 |
This may affect government efforts at curtailing the spread of HIV/AIDS (Famoroti et al., 2013; Reis et al., 2005). Several studies on HCWs attitude to care of HIV patients have been reported from other countries. Anderson, Zheng, Wu, Li, and Liu (2003) reported that 24% of hospital-based health care professionals in China expressed reservations about caring for HIV infected patients. Hesketh, Duo, Li, and Tomkins (2005) reported that 30% of Chinese HCWs were not willing to treat people with HIV/AIDS and 81% would prefer not to. Similarly, about half of Iranian nursing staff were unwilling to care for patients with HIV/AIDS (Askarian, Hashem, Jaafari, & Assadian, 2006) and 84% of Jordanian nurses had negative attitudes towards them (Hassen & Wahsheh, 2011).
|
study
| 98.1 |
In Poland, 56% of doctors and 65% of nurses supported HIV testing of all inpatient admissions(Gañczak, 2007) and 86% of HCWs in India agreed with pre-operative HIV testing (Mahindra et al., 2007). Half of HCWs in a study carried out in South Africa reported they had observed or experienced patients being required to undergo HIV tests before surgery (Famoroti et al., 2013). A study done in Abeokuta, Nigeria reported that 13.9% of trained nurses were unwilling to take vital signs and carry out physical examination on HIV-positive patients (Sadoh et al., 2006). However, the attitude of other categories of HCWs in a tertiary hospital apart from doctors and nurses have not been explored. HCWs may become infected with HIV as a result of their personal sexual behavior. In addition to risks within the community within which they live, health service personnel face additional occupational risks from handling non-sterile injecting equipment or accidental exposure to blood or blood products. The frequency of exposure to blood and body fluids (BBFs) among HCWs varies according to occupation, procedures performed and use of preventive measures (Braczkowska et al., 2010; Hadadi, Afhami, Karbakhsh, & Esmailpour, 2008; Leszczyszyn-Pynka, Kłys-Rachwalska, Sacharczuk, & Boroń-Kaczmarska, 2004). Nurses were reported to have the most exposure in Poland (Braczkowska et al., 2010; Leszczyszyn-Pynka et al., 2004) and Taiwan (Hsieh, Chiu, Lee, & Huang, 2006).
|
review
| 98.9 |
In view of the risk of occupational exposure to HIV, it is important for HCWs to go for HIV counselling and testing (HCT). This is more so because they serve as source of information on HIV/AIDS and play a key role in mobilizing clients for HCT. HCT is a critical point to prevention, care, support and treatment for all people, and particularly for those already infected and affected. Tarwireyi and Majoko (2003) reported that 87.4% of HCWs in Zimbabwe had not gone for HCT and 77% did not want it done for reasons such as not being able to cope with the result, not having enough courage to go for the test and not wanting to do the test since HIV/AIDS had no cure. Similarly, 33% of HCWs in Zambia had ever been tested for HIV (Kiragu et al., 2007). In Ilorin, Nigeria 41.4% of HCWs had ever been screened for HIV infection and 65.2% of them were willing to know their status (Araoye, Salami, & Sekoni, 2004). In another study conducted among health workers in Ilorin, only 16.1% had ever been tested for HIV and psychological worry was the main reason for not going for HCT (Akande, 1999).
|
study
| 99.8 |
HCWs are expected to mobilize clients for HCT but if they are unwilling to take the test themselves they may be ineffective in this role. The University College Hospital (UCH) in Ibadan is the foremost tertiary health facility and a major referral center for other tertiary facilities in Nigeria. It has various cadres of HCWs and trainees and a WHO reference laboratory for HIV. The proportion of HCWs who have been tested for HIV is unknown. There is little data on UCH HCWs’ willingness to participate in HCT. Other studies addressing attitudes of HCWs to HIV-positive patients in Nigeria have focused on nurses. Little information is available about the attitude of doctors, laboratory scientists and ancillary staff such as porters and hospital maids.
|
study
| 99.94 |
The study was carried out at University College Hospital (UCH), in Ibadan, Southwestern Nigeria. The hospital was established in 1957. It has 53 service and clinical departments and runs 75 consultative outpatient clinics per week in 45 specialty and sub-specialty disciplines. The hospital has 31 wards and a total bed capacity of 817. Inpatients admissions exceed 10,000 while outpatient clinic attendance approximate to over 17,000 a year. There is an antiretroviral clinic located within the hospital.
|
study
| 97.2 |
The study design was cross-sectional. The study population comprised all HCWs in the hospital. HCWs, as defined in this study, are clinical and other staff who have regular clinical contact with patients. These include doctors, dentists and nurses, paramedical professionals such as laboratory scientists, physiotherapists, radiographers and porters.
|
study
| 99.94 |
Semi-structured, self-administered questionnaires developed from the reviewed literature were used to collect information on socio-demographic characteristics, occupational characteristics, risk of exposure to HIV, attitude of HCWs to PLWHA, willingness to participate in HCT, factors affecting HCT uptake, and barriers to HCT uptake. The questionnaire was pretested among HCWs in Ladoke Akintola Teaching Hospital, another teaching hospital in Southwest Nigeria. Ethical approval to carry out the study was obtained from the Joint University of Ibadan and University College Hospital Institutional Review Committee and informed consent was obtained from respondents.
|
study
| 100.0 |
The heads of all clinical departments and unions of various categories of HCWs were informed about the study. In each department, the staff lists were obtained and used to distribute questionnaires to staff. Departmental secretaries distributed and collected the questionnaires from staff members in their respective departments.
|
other
| 99.8 |
All departments whose doctors are members of the College of Surgeons were listed as Surgical departments. Departments whose doctors are members of the College of Physicians were listed as Medical departments except laboratory departments which were categorized as Laboratory departments. Nursing staff were categorized as Nursing department. Ward maids, surgical attendants, dental hygienist, porters were categorized as other departments.
|
other
| 99.94 |
Table 1 shows socio-demographic characteristics of respondents. A total of 1500 questionnaires were administered and 977 completed questionnaires were returned giving a response rate of 65.1%. Mean age of respondents was 35.0 ± 8.4 years. Two-thirds were aged below 40 years. About two-thirds were females (69.7%) and ever married (65.7%). Almost all (96.9%) had tertiary education. Majority (75.1%) were doctors and nurses.Table 1.Socio-demographic characteristics of respondents.Socio-demographic characteristicsn (%) N = 977Age group (years) <40596 (61.0) ≥40214 (21.9) Missing167 (17.1) Mean Age (±SD) years35.0 (±8.4)Sex Male296 (30.3) Female681(69.7)Marital status Never married335(34.3) Ever married/cohabiting642 (65.7)Level of education None4 (0.4) Primary9 (0.9) Secondary18 (1.8) Tertiary943(96.9)Religion Christianity872(89.3) Islam97 (9.9) Others8 (0.8)Occupation Nurses405 (41.5) Doctors328 (33.6) Lab scientists78 (8.0) Othersa126 (12.9) Missing40 (4.0) aWard maids, surgical attendants, dental hygienist, and porters.
|
study
| 100.0 |
Table 2 shows the responses on perception of exposure to HIV at work and experience of workplace accidents with exposure to BBFs. Majority of respondents reported that their jobs involved exposure to BBFs (92.3%), use of needles (88.1%) and direct care of patients (87.2%). Staff from the nursing department reported the highest exposure to BBFs (98.9%) and use of needles (97.8%) compared to other departments (p < .05). Respondents in the nursing department (96.7%) reported highest involvement in the direct care of patients (p < .05). Two-thirds of respondents (67.7%) felt they were adequately protected against HIV infection in the workplace. Respondents in the medical (56.9%) and surgical (56.9%) departments reported the lowest level of protection in the work place (p < .05). Forty percent of respondents reported that their risk of contracting HIV at work was high. A higher proportion of respondents from surgical departments (49.7%) reported a high risk of contracting HIV at work, followed by those in the laboratory departments (41.3%) (p < .05).Table 2.Risk of exposure and workplace accidents of HCWs by departments.Risk of exposureMedical departmentsn (%)Surgical departmentsn (%)Laboratory departmentsn (%)Nursing departmentsn (%)Other departmentsan (%)Totaln (%)p ValueRisk of exposure of HCWs Job involves exposure to BBFs170 (93.4)185 (98.4)94 (87.9)365 (98.9)60 (59.4)874 (92.3).000 Job involves use of needles167 (92.3)184 (97.4)98 (90.7)359 (97.8)26 (25.5)834 (88.1).000 Job involves direct care of patient153 (84.5)175 (93.6)71 (67.6)356 (96.7)65 (65.7)820 (87.2).000 Feel adequately protected in the work place103 (56.9)107 (56.9)72 (70.6)276 (75.6) 76 (75.2)634 (67.7).000 High risk of contracting HIV at work73 (40.1)96 (49.7)45 (41.3)149 (40.9)17 (16.7)380 (40.0).000Workplace accidents in the last one year with potential risk of infection Accidental exposure in the last one year100 (55.9)115 (60.2)36 (33.0)154 (43.0)35 (35.4)440 (47.0).000 Splash of BBFs on intact skin81 (77.1)88 (77.2)26 (40.6)125 (64.4)11 (22.0)331 (62.8).000 Needle stick injury61 (57.5)64 (54.7)17 (25.8)69 (37.1)11 (20.8)220 (42.0).000 Cuts from broken bottles19 (20.7)30 (29.7)5 (8.5)53 (31.0)7 (14.3)114 (24.2).002 Splash of BBFs on mucosal lining19 (20.2)44 (40.7)6 (10.3)30 (18.1)5 (10.2)104 (21.9).000 Splash of BBFs on open wound11 (12.1)22 (21.4)2 (3.4)33 (19.5)9 (18.8)77 (16.4).000 Cuts from scalpel 6 (7.3) 18 (19.8)3 (5.4)27 (16.7)3 (6.4)57 (13.0).013 aOther departments include ward maids, surgical attendants, dental hygienist and porters.
|
study
| 100.0 |
About half (47.0%) of respondents had accidental exposure to BBFs in the year preceding the study. Types of exposure most commonly reported were splash of BBFs on intact skin (62.8%) and needlestick injuries (42.0%). Setting of intravenous lines (19.5%), surgical operations (15.9%) and recapping of needles (15.0%) were the most commonly reported activities being carried out during exposure to BBFs. Accidental exposure in the last one year was mostly reported by those in the surgical departments (60.2%). Cuts from broken bottles were mostly reported by staff from the nursing department (31.3%) (p < .05).
|
study
| 100.0 |
Table 3 shows the attitude of HCWs to HIV-positive patients; attitude about administrative issues with regard to HIV and attitude to HCT. Majority (99.4%) of respondents believed that the quality of life of patients with HIV/AIDS can be improved with counselling. Very few (7.9%) will however refuse to treat a patient with HIV/AIDS to protect themselves and their families. Half of the staff from the laboratory departments believed that people with HIV/AIDS should be on a separate ward in a hospital or clinic. Majority of respondents believed that all obstetric (91.2%) and surgical (89.2%) patients should be routinely tested for HIV on admission to hospital. A higher proportion of nurses than other staff believed that all patients should be routinely tested for HIV on admission to hospital (p < .05). Very few respondents (26.6%) reported that charts/beds of patients with HIV/AIDS should be marked so clinic/hospital workers can be aware and 23.7% felt that health professionals with HIV/AIDS should not work in any area of health care that requires patient contact.Table 3.Attitude of HCWs to HIV-positive patients, HIV/AIDS and routine HIV testing.Attitude of HCWsMedical deptsn (%)Surgical deptsn (%)Laboratory deptsn (%)Nursing deptsn (%)Other deptsn (%)Totaln (%)p ValueAttitude of HCWs to HIV-positive patients The quality of life of patients with HIV/AIDS can be improved with counselling184 (100)190 (99.0)111 (100)303 (99.2)100 (99.0)948 (99.4).42 People with HIV/AIDS should be on a separate ward in a hospital or clinic.48 (26.4)48 (25.1)54 (50.0)86 (23.4)46 (46.0)282 (29.7).000 Can refuse to treat a patient with HIV/AIDS to protect self and family22 (12.0)19 (9.9)4 (3.7)21 (5.8)9 (8.9)75 (7.9).000Attitude of HCWs to HIV /AIDS All obstetric patients should be routinely tested for HIV on admission to hospital161 (88.0)176 (92.1)94 (87.9)346 (95.6)85 (83.3)862 (91.2).002 Staff and health care professionals should be told when a patient has HIV/AIDS so they can protect themselves159 (18.7)173 (20.3)92 (10.8)336 (39.4)92 (10.8)852 (89.8).218 All surgical patients should be routinely tested for HIV on admission to hospital157 (85.8)164 (86.8)96 (87.3)337 (93.1) 90 (88.2)844 (89.2).158 All patients should be routinely tested for HIV on admission to hospital106 (58.2)104 (54.5)70 (64.2)291 (81.1)69 (68.3)640 (67.9).000 There are instances where it is appropriate to test for a patient for HIV/AIDS without the patient’s knowledge or permission111 (61.7)112 (58.3)56 (50.0)205 (56.8)56 (55.4)540 (57.1).016 The charts/beds of patients with HIV/AIDS should be marked so clinic/hospital workers can know36 (19.7)68 (35.4)29 (26.9)81 (22.3)38 (37.6)252 (26.6).000 A health professional with HIV/AIDS should not be working in any area of health care that requires patient contact33 (18.1)47 (24.9)26 (23.9)90 (25.3)2/;;6 (25.5)222 (23.7).001Attitude to routine HCT of HCWs All prospective health care workers should submit to mandatory HCT92 (50.5)108 (56.8)70 (63.6)236 (65.4)69 (67.6)575 (60.8).006 HIV screening should not be performed on health workers19 (10.5) 39 (21.0) 18 (18.8) 48 (14.2) 19 (20.7)143 (16.0).012 HCT should be part of pre-employment medical examination for health workers104 (58.1)109 (58.6)64 (67.4)230 (67.6)57 (60.6)564 (63.1).073 All dentists and surgeons should be tested for HIV120 (67.4)116 (62.0)72 (73.5)232 (68.6) 63 (65.6)603 (67.2).611 Regular HCT should be performed on health workers at least once a year 110 (61.8) 106 (57.6)68 (72.3)237 (70.7) 65 (67.7)586 (66.1).094
|
study
| 99.9 |
About two-thirds of respondents (60.8%) believe that all prospective HCWs should submit to mandatory HCT, 63.1% felt that HCT should be part of pre-employment medical examination for health workers and 66.1% felt that regular HCT should be performed on health workers at least once a year.
|
other
| 99.9 |
Table 4 shows HCWs’ practice with regard to HIV-positive patients and participation in HCT. Very few respondents (3.8%) reported they had refused to care for a patient with HIV/AIDS, verbally mistreated a patient with HIV/AIDS (4.1%), and gave confidential information to a non-family member (10.6%) and family member (12.0%).Table 4.HCWs’ behavior towards HIV-positive patient and participation in HCT.HCWs’ practiceMedical depts.n (%)Surgical deptsn (%)Laboratory deptsn (%)Nursing deptsn (%)Other deptsn (%)Totaln (%)p ValueRefused a patient with HIV/AIDS admission 7 (3.9) 6 (3.1) 4 (3.7) 5 (1.4) 1 (1.1) 23 (2.5).000Observed others refuse a patient with HIV/AIDS admission39 (21.5)32 (16.7)13 (12.0)33 (9.4)10 (10.6)127 (13.7).000Refused to care for a patient with HIV/AIDS 7 (3.9)11 (5.7) 4 (3.7) 10 (2.8)3 (3.2)35 (3.8).000Observed others refuse to care for a patient with HIV/AIDS64 (35.4)67 (35.3)20 (18.3)62 (17.7)15 (16.1)228 (24.7).000Verbally mistreated a patient with HIV/AIDS6 (3.3)8 (4.2)4 (3.7)16 (4.5) 4 (4.3)38 (4.1).000Observed others verbally mistreat a patient with HIV/AIDS55 (30.4)49 (25.7)18 (16.5)70 (20.2) 14 (15.4)206 (22.4).000Gave confidential information to a family member22 (12.4)26 (13.8)15 (14.4)37 (10.7)9 (10.0)109 (12.0).000Observed others give confidential information to a family member51 (28.5)54 (28.3)26 (24.8)60 (17.2)14 (15.4)205 (22.4).000Gave confidential information to a non-family member19 (10.5)29 (15.2)8 (7.6)30 (8.6)11 (12.1)97 (10.6).000Observed others give confidential information to a non-family member32 (17.7)41 (21.4)12 (11.7)42 (12.0)19 (20.7)146 (15.9).000HCWs’ participation in HCT Ever gone for HCT120 (66.3)91 (48.7)41 (41.0)185 (54.7)40 (42.1)477 (52.9).000 Ever provided HCT information155 (86.6)125 (67.9)58 (58.6)241 (72.2)49 (51.6)628 (70.5).000 Referred any for HCT141 (78.3)99 (53.5)57 (57.0)186 (56.0)33 (34.7)516 (57.8).000
|
study
| 99.94 |
Eighty percent of respondents had ever heard of HCT and 65% were aware of an HCT center in UCH. About half of respondents (52.9%) had gone for HCT themselves and two-thirds (66.0%) of these because they wanted to know their status. Among those who had not gone for HCT, 68.6% of them were willing to go. Lack of confidentiality (8.5%), not perceived as being at risk (7.5%), not interested in knowing (6.8%) and lack of social security for HIV-positive workers (5.4%) were some of the reasons for unwillingness to go for HCT. Majority of respondents (70.5%) had ever provided HCT information to patients and 57.8% had ever referred anyone for HCT. A higher proportion of respondents in Medical departments than other departments had ever gone for HCT (66.3%), provided HCT information (86.6%) and referred any for HCT (78.3%) (p = .000).
|
study
| 99.94 |
Table 5 shows bivariate analysis of socio-demographic characteristics of HCWs and accidental exposure to BBFs in the last one year, attitude to HIV patients and HCT uptake. Factors associated with accidental exposure in last one year were age <40 years (p = .004), being in medical, surgical or nursing departments (p = .000) and having spent less than five years at work (p = .02). Working in laboratory departments (p = .000) and having spent less than five years at work (p = .02) were associated with poor attitude of HCWs to HIV patients in terms of segregation on separate ward. The only factor associated with poor attitude of HCWs to HIV patients in terms of mandatory HIV test for all patients was being in the nursing department (p = .000).Table 5.Bivariate analysis of socio-demographic characteristics and accidental exposure to BBFs, attitude to HIV patients and HCT Uptake. Outcome variables Socio-demographic characteristicsAccidental exposure to BBFsHIV patients should be on separate wardsRoutine HIV test for all patientsHCT uptakeAge group(years) <40290 (50.7)*177 (30.3)383 (65.9)314 (56.0)* ≥4077 (37.6)52 (25.0)147 (70.7)90 (47.2)Department Medical100 (55.9)**48 (26.4)**106 (58.2)**120 (66.3)** Surgical115 (60.2)48 (25.1)104 (54.5)91 (48.7) Nursing154 (43.0)86 (23.4)291 (81.1)185 (54.7) Others35 (35.4)46 (46.0)69 (68.3)40 (42.1) Laboratory36 (33.0)54 (50.0)70 (64.2)41 (41.0) Length of years at work ≤5168 (52.0)*107 (32.7)*214 (66.0)162 (51.3) >5193 (44.1)112 (24.9)296 (66.7)242 (57.3)*p < .05.**p < .001.
|
study
| 100.0 |
Logistic regression analyses of factors significantly associated with accidental exposure to BBFs in the last one year, attitude to HIV patients and HCT were done. Table 6 shows that the predictors of accidental exposure to BBFs in the last year. The main predictor of accidental exposure in the last year was working in surgical department, OR = 1.7, 95% CI (1.1–2.6). HCWs aged <40 years, OR = 5.5, 95% CI (1.9–15.9), who had worked for greater than five years, OR = 3.6, 95% CI (1.4–9.3) and working in nursing department, OR = 6.8, 95% CI (1.7–27.1) were more likely to report exposure to BBFs. Respondents in the nursing departments were more likely to require routine HIV test for all patients, OR = 3.9, 95% CI (2.4–6.2). HCWs in the laboratory departments were more likely to believe that HIV patients should be on separate wards compared to those in the medical departments OR = 3.6, 95% CI (1.9–7.0). Predictors for HCT uptake were age <40 years, OR = 1.6, 95% CI (1.1–2.4), having worked for greater than five years, OR = 1.5, 95% CI (1.03–2.2) and working in medical department, OR = 1.7, 95% CI (1.1–2.8).Table 6.Logistic regression analysis of socio-demographic and accidental exposure to BBFs, attitude to HIV patients and HCT uptake. Outcome variables Socio-demographic characteristicsAccidental exposure to BBFs in last one yearHIV patients should be on separate wardsRoutine HIV test for all patientsHCT uptakeAge group (years) <401.2 (0.8–1.8)1.2 (0.7–1.8)–1.6 (1.1–2.4)* ≥4011 1Department Medical2.1 (1.1–3.9)*0.3 (0.1–0.5)**0.8 (0.4–1.5)2.0 (1.1–4.0)* Surgical2.7 (1.4–5.2)*0.3 (0.2–0.6)**0.7 (0.4–1.3)1.0 (0.5–1.9) Nursing1.6 (0.9–2.9)0.3 (0.2–0.6)**3.0 (1.6–5.6)*1.2 (0.6–2.1) Others0.7 (0.3–1.6)0.6 (0.3–1.2)1.2 (0.6–2.5)0.9 (0.4–1.9) Laboratory1111Length of years at work ≤51.3 (0.9–1.9)1.3 (0.9–2.0)–– >511 *p < .05.**p < .001.
|
study
| 99.94 |
Majority of HCWs reported that their jobs involved exposure to BBFs. Setting of intravenous lines, surgical operations and recapping of needles were the most commonly reported activities being carried out during exposure to BBFs. This is similar to the findings of other studies which reported that recapping of needles (Leszczyszyn-Pynka et al., 2004), performing surgical procedures (Lal, Meghachandra, Singh, Malhotra, & Ingle, 2006), handling surgical equipment (Gańczak, Szych, & Karakiewicz, 2012), handling medical wastes (Rapparini et al., 2007), disposal into sharp containers (Do et al., 2003) and blood withdrawal (Muralidhar, Singh, Jain, Malhotra, & Bala, 2015) were the common procedures leading to exposure to BBFs. Nurses reported the highest use of needles and exposure to BBFs. This is similar to findings by Hsieh et al. (2006) and Hadadi et al. (2008) and is probably because needles are used mostly by nurses (WHO, 2014a). About half of HCWs reported accidental exposure to BBFs in the last year with staff in the surgical departments reporting the highest accidental exposures, the highest number of splash of BBFs on intact skin and open wounds, needle stick injuries and cuts from scalpel. Surgical staff were three times more likely to experience accidental exposure to BBFs than those in the Laboratory departments. Surgeons have contact with BBFs of patients during surgical operations and non-availability of relevant devices has been reported as the most important factor militating against the use of universal precautions by surgeons in developing countries (Olapade-Olaopa, Salami, & Afolabi, 2006). Splash of BBFs on intact skin was the most commonly reported exposure. Other reports by WHO (2014a), Braczkowska et al. (2010), Davanzo, Frasson, Morandin, and Trevisan (2008) and Lal et al. (2006) indicated that needle stick injuries were the commonest type of exposure to BBFs. This is probably because these studies were conducted among doctors and nurses alone while our study included other groups of health workers such as laboratory scientists, laboratory attendants and ward maids who do not frequently use needles. The high frequency of exposure by splash of BBFs on intact skin in this population constitutes a significant risk as it can be a source of infection for Ebola virus disease among health care workers (WHO, 2014b).
|
study
| 99.9 |
One-third of respondents reported they were not adequately protected from exposure to BBFs in the workplace. This is of great concern especially in the surgical departments where the highest risk of contracting HIV at work and the lowest level of protection were reported. In order to mitigate this risk, known strategies to protect workers and prevent exposure such as standard precautions, immunization against hepatitis B, provision of personal protective equipment and management of exposures should be adhered to.
|
other
| 99.9 |
HCWs in this study had positive attitudes towards PLWHA. Only few respondents will mark charts/beds of patients with HIV/AIDS and 24% believed health professionals with HIV/AIDS should not work in any area of health care that requires patient contact. This proportion is lower than 40% of health care professionals in health care facilities in four Nigerian states who believed that health professional with HIV/AIDS should not work in any area of health care that requires patient contact (Reis et al., 2005). Very few, 7.9%, would refuse to treat patients with HIV/AIDS. This is similar to 9% of health care professionals in health care facilities in four Nigerian states who would refuse to care for PLWHA (Reis et al., 2005). However, a higher proportion (15%) of HCWs in Abeokuta were unwilling to take vital signs and carry out physical examination on PLWHA (Sadoh et al., 2006).
|
study
| 99.94 |
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