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{ "caption": "Age 14.3. After seven months of treatment. Note the mechanics for mutual derotation of teeth 41 and 44.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-10-1746-160X-3-10-13.jpg" }
000900
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 19.7. With and without thermoplastic appliance for temporary replacement of 21. Note exact congruency of midline. Crossbite in region of teeth 24 and 25 corresponds to plaster surgery planning. Anteriorly, however, probably due to tongue thrust, a slight reopening tendency of the bite seems to have occurred. Logopedics (speech therapy) has been recommended for this reason.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-11-1746-160X-3-10-22.jpg" }
000901
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 13.2. Panoramic x-ray. Congenitally missing tooth 28 and impacted teeth 18, 17, 14, 13, 23, 27, 38, 33, 43 and 48. Because of extreme crowding, impaction, and space discrepancy, extraction of teeth 17, 14, 13, 23, 38, 33, 43, and 48 were considered. Tooth 18 will be left in place because of its malposition.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-12-1746-160X-3-10-10.jpg" }
000902
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 16.4. Situation after 1.2 years in braces in order to parallelize 11 and 22 for later prosthodontic rehabilitation. Teeth 24 and 25 had not been bonded because of idiopathic root resorption (compare panographic x-ray, Fig. 16). Extraorally: With and without thermoplastic retainer for temporary replacement of 21. Intraorally: Teeth 11 and 22 were parallelized.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-13-1746-160X-3-10-17.jpg" }
000903
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 9.4. Situation after surgical exposure of upper central incisors at age 9.1. Extrusion of upper central incisors with a modified functional appliance (Fränkel 3), which was not applied to treat the Class III, but only to extrude the upper central incisors and to stretch the soft tissues to facilitate lip closure.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-15-1746-160X-3-10-2.jpg" }
000904
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Left: age 18.2. Panographic x-ray 5 months before surgery. Right: age 18.6. Tracing of lateral x-ray before orthognathic surgery.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-17-1746-160X-3-10-18.jpg" }
000905
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 15.1. One month before insertion of fixed appliance in maxilla. Extraorally: Hypertelorism, vertical excess of lower face impeding lip closure at rest, laterognathia, Class III. Intraorally: Class III, anterior open bite, unilateral crossbite, and midline deficiency.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-18-1746-160X-3-10-16.jpg" }
000906
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 13.7. Situation after surgical exposure and orthodontic extrusion of 34 and 44 with a removable appliance and before bonding of the fixed appliance. Extraorally: Hypertelorism and proptosis. The latter could be seen as a consequence of midfacial hypoplasia and retroposition of infraorbital rim. Trapezoidal shape of mouth, impossibility of lip closure at rest due to vertical excess of lower third of face. Intraorally: Class III with reclined lower incisors, anterior open bite, bilateral crossbite, and crowding in both arches. V-shaped maxillary arch with midline \"pseudocleft\" due to severe fibrous hyperplasia of lateral palatine ridges.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-19-1746-160X-3-10-11.jpg" }
000907
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 14.2. After five months in braces. Panographic x-ray and tracing of lateral x-ray. Because of mandibular growth and orthodontic decompensation (the latter is a prerequisite for orthognathic surgery) and insufficient growth of maxillary complex, the open bite and Class III worsened as compared with lateral x-ray at age 10.7 (compare Fig. 10). Tooth 18 will be left in place because of its malposition.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-2-1746-160X-3-10-12.jpg" }
000908
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 10.8. Panoramic x-ray. Situation after extrusion of upper central incisors. Lack of space for 13, 23, 38, 33, 43, and 48; transposition of 22 and 23, second (supernumerary) canine in region 24, agenesis of 25. Ectopic position of 27.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-22-1746-160X-3-10-3.jpg" }
000909
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 14.3. Panographic x-ray. Situation after extraction of 21 due to internal resorption at age 13.5. Situation after surgical removal of 18 and 28 and surgical exposure and bonding of 17, 23, and 27; before attempting orthodontic extrusion of 17, 23, and 27. Note severe idiopathic resorption of teeth 24 and 25.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-3-1746-160X-3-10-15.jpg" }
000910
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 13.2. After 21 months in braces. Open-bite reduction was obtained by second order bends and vertical elastics. Please note transposition of 22 and 23. Upper teeth follow the lower lip smile line. Two months before genioplasty.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-5-1746-160X-3-10-6.jpg" }
000911
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 8.8. Extraorally: Hypertelorism, vertical excess of the lower third of the face, trapezoidal upper lip, forced lip closure possible, but difficult. Intraorally: Dentitio tarda, crowding, Angle Class III with dental compensation by retrusion of lower incisors, circular open bite with unilateral crossbite.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-6-1746-160X-3-10-1.jpg" }
000912
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Age 18.6. After surgery, during distraction. Maxillary complex is \"guided\" by intermaxillary elastics during distraction phase. Bite planes have been mounted on 36 and 46, in order to overcome initial crossbite.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821014-8-1746-160X-3-10-21.jpg" }
000913
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Longitudinal ultrasonograms of the supraspinous ligament. (a) Normal appearance of the supraspinous ligament (b) A representative hypoechogeneic lesion (c) A representative hyperechogeneic lesion (d) A representative alteration of supraspinous ligament fibre pattern.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821016-1-1746-6148-3-3-1.jpg" }
000914
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Fascicular arrangement of spindle cells with prominent nuclear palisading and perinuclear cytoplasmic vacuoles (×200).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821025-0-1477-7819-5-20-4.jpg" }
000915
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "CT scan shows the mass (*) along the left anterior aspect of the anal canal.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821025-1-1477-7819-5-20-3.jpg" }
000916
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Endoanal ultrasonography (transverse plain) shows the mass (*) located along the left anterior aspect of the anal canal.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821025-2-1477-7819-5-20-2.jpg" }
000917
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "KIT staining in GIST. Cytoplasmic and perinuclear strongly positive tumour cells (×200).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821025-3-1477-7819-5-20-5.jpg" }
000918
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Endoanal ultrasonography (longitudinal plain) shows a bilobate, circumscribed 4 × 2 cm mass.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821025-4-1477-7819-5-20-1.jpg" }
000919
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Hematoxylin and eosin stain. (A) Low-power magnification (10×) shows irregular trabeculae and glandular structures, separated by hypocellular fibrous bands. Note the absence of cystic spaces within the glands. (B) Higher magnification (40×) demonstrates a homogenous population of polygonal cells with clear cytoplasm and small, central, round nuclei.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821026-0-1477-7819-5-26-3.jpg" }
000920
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Periodic Acid-Schiff (PAS) stain. (A) Strong reaction with PAS is evident within the cytoplasm of the polygonal cells. (B) Staining disappears in the presence of diastase.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821026-1-1477-7819-5-26-4.jpg" }
000921
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Distal pancreas, gross specimen. An ovoid, well circumscribed, solid mass measuring 4.2 × 2.5 × 2.0 cm is seen adjacent to the pancreatic duct and extending to the periphery of the specimen (arrow).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821026-2-1477-7819-5-26-2.jpg" }
000922
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "CT scan of the abdomen with contrast. A heterogeneously enhancing, solid mass can be identified at the junction of the head and body of the pancreas (arrow).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821026-3-1477-7819-5-26-1.jpg" }
000923
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Both gross and microscopic changes in SD rats' tongues mucosas. A. Normal mucosa of tongue base at 6th week (gross observation and HE ×200); B. Epithelial dysplasia of tongue base at 24th week (gross observation and HE ×200); C. Squamous cell carcinoma of tongue base at 36th week (gross observation and HE ×200). T represents tongue.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821034-4-1471-2407-7-40-1.jpg" }
000924
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Examples of c-Fos immunoreactivity in BNSTd for WT (A) and CRFR1-/- (B) mice. Examples of Egr-1 immunoreactivity in MPOM in WT (C) and CRFR1-/- (D) mice.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821036-6-1471-2202-8-17-7.jpg" }
000925
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Cellular location of DmSnR60 and snm60 molecules. Top-left panel: whole mount in situ hybridization of DmSnR60 specific probes to adult ovaries. DmSnR60 molecules are detected at all stages of oogenesis, in the nurse and the follicle cells (see enlargement on bottom-right). Analysis of the large polyploid nurse-cell nuclei reveals that the DmSnR60 molecules are located in the peripheral nucleolar structures. Hybridization of the sense probe was performed as control (top-right). Bottom-left panel: in situ hybridization of DmSnR60 probes to larval intestines. Top-right panel: whole mount in situ hybridization of snm60 specific probes to adult ovaries. snm60 molecules accumulate specifically in the nurse cell nuclei from stage 7 of oogenesis, and are not detected in the follicle cells (see also the enlargement at bottom-right). Hybridization of the sense probe was performed as control (top-right). Bottom-right panel: in situ hybridazion of snm60 probes to larval intestines.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821038-4-1471-2199-8-15-8.jpg" }
000926
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Complete transection of the brachial artery just above the level of the elbow.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821318-0-1749-7922-2-6-1.jpg" }
000927
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "The brachial artery repaired with a segment of ipsilateral cephalic vein used as a reversed interposition graft.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821318-1-1749-7922-2-6-2.jpg" }
000928
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Proliferative activity in the murine pulmonary vasculature in response to hypobaric hypoxia. Frozen lung sections double immunolabeled for Ki67 and α-smooth muscle actin were used for the detection of proliferating cell within the walls of intrapulmonary vessels. Nuclei of individual cells were visualized by staining with DAPI. Exemplary immune histochemistries are demonstrated in (A). The results of a quantitative analysis of the number of proliferating cells/vessel depending on time of exposure to hypobaric hypoxia is given in (B). In the boxplots the middle horizontal line indicates the median, the top and bottom of each box identifies the upper and lower quartiles of the distribution and the top and bottom horizontal line gives the total distribution (n = number of animals. ** p ≤ 0.01).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821322-5-1465-9921-8-15-1.jpg" }
000929
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "CT scan showing bilateral adrenal enlargement consistent with lung cancer metastases (asterisk).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821329-0-1477-7819-5-27-1.jpg" }
000930
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "FKBP52 expression in human prostate. Prostate tissue was obtained from adult male surgically treated for benign prostatic hyperplasia. The tissue was fixed, paraffin embedded and sectioned before staining. Sections were immunostained with antibody specific for FKBP52 (A) and a consecutive section was immunostained with only secondary antibody for background detection (B). The strongest staining for FKBP52 is in the cytoplasm of ductal epithelial cells. (Sections photographed at 20× magnification).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821330-0-1477-7827-5-8-1.jpg" }
000931
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "FKBP52 expression in human pre-pubertal genital skin. Foreskin samples from hypospadia patients and control individuals were obtained from surgery. The tissues were fixed, paraffinembedded and sectioned before staining protocols. The upper panel shows FKBP52 staining in mild hypospadia patient (A), severe hypospadia patient (C) and healthy control (E). The background controls for these samples using only the secondary antibody are seen in (B, D and F). The FKBP52 expression is predominantly cytoplasmic, localized in the epidermal region of the foreskin. Similar pattern and intensity are observed in healthy individuals and in hypospadia patients. (Sections photographed at 20× magnification).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821330-1-1477-7827-5-8-2.jpg" }
000932
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Expression of galectin-1. Immunocytochemistry staining of galectin-1 (red, a) beta-tubulin (green, b), and merged image (c). (d) Dosage of galectin-1 by ELISA at different concentrations of MSCs.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1821333-5-1471-2164-8-65-3.jpg" }
000933
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Significant activity (q(FDR)<.001 for both activation maps) for the contrast between single visual trials (orange) and single auditory trials (green) trials versus ‘null trials’ baseline. LH – left hemisphere, RH – right hemisphere. A list of cortical regions commonly activated by single visual trials and single auditory trials is provided in Table 1.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1824707-0-ponep0000320pg002.jpg" }
000934
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Significant activity (p<.03, uncorrected; voxel threshold>60) for the whole brain contrast between dual task trials with long SOA and dual task trials with short SOA in a) frontal cortex and b) middle temporal gyrus. Details are provided in Table 2. Time courses of activity were extracted for dual task trials with short and long SOA and nontarget letters (dual task_200_nontarget; dual task_800_nontarget), dual task trials with short and long SOA and successfully identified letter targets (dual task_200_hit; dual task_800_hit), single visual trials with nontargets and successfully identified letter targets (single task_vis_nontarget, single task_vis_hit), single auditory trials (single task_aud) and dual task trials with short SOA and letter target misses (dual task_200_miss), in contrast to the null trial activation baseline. Error bars indicate standard errors.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1824707-5-ponep0000320pg003.jpg" }
000935
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Axin 2 expression in islet cell tumors and adenocarcinomas. Pseudocolored image of axin 2 expression (top). Image represents mean centered values of sample/reference ratios. Representative immunohistochemistry with rabbit anti-axin2 antibodies in normal pancreas (bottom left) and pancreatic adenocarcinoma (bottom right).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1824711-3-ponep0000323pg005.jpg" }
000936
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Immunohistochemistry of paraffin embedded pancreatic adenocarcinomas. Anti-galectin 4 (LGALS4) antibody (panel a). In situ hybridization for collagen 17A1 (COL17A1) (panel b) and mucin 13 (MUC13) (panel c). In situ hybridization sense control for MUC13 (panel d).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1824711-5-ponep0000323pg003.jpg" }
000937
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Apical site of the CAF insertion into the LV (*) and the adjacent muscular ventricular septal defect shown by color Doppler.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828047-0-1476-7120-5-10-2.jpg" }
000938
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Two dimensional (left) and color Doppler (right) on day one (atypical short axis view of LV). The large coronary artery fistula drains (arrow) into the left ventricular apex (*). The LAD (#) was dilated up to 4.4 mm in diameter along its course.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828047-1-1476-7120-5-10-1.jpg" }
000939
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Immunochemical examination of RAGE expression in lung development. Two, four, seven day and adult rat lungs were stained for RAGE followed by a hematoxylin counter stain. A gradual increase in positive staining was seen in the alveolar parenchyma with post-natal lung development, with marked staining in type I pneumocytes in the adult.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828052-3-1471-213X-7-15-5.jpg" }
000940
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Isolation of Bovine Mesenteric Lymphatic Endothelial Cells. A/ Evan's blue dye, when injected into the lymph node of bovine mesentery (***), outlined lymphatic vessels (**), but not blood vessels (*). B/ A mixed cell population did not form a monolayer in culture. C/ A mixed cell population of predominantly smooth muscle cells and fibroblasts formed circular patterns in culture. D/ Typical morphology of a cell population predominantly comprising of fibroblasts. E/ Morphology of a cell population predominantly comprising of smooth muscle cells. F/ Morphology of a cell population predominantly comprising of lymphatic endothelial cells. G/ Mixed cultures of cells extracted from lymphatic vessels spontaneously formed lymphatic tube-like structures with ends attached to the walls of the tissue culture dish. H/ Enlargement of the lymphatic tube-like structure seen in \"G\".", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828055-5-1471-2121-8-10-1.jpg" }
000941
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Differential gene expression following positive or negative selection reflects cellular contamination rather than activation. (A) Venn diagrams showing number and overlap of statistically significant, differentially expressed genes (as defined in materials and methods) in each independent experiment (roman numerals). The number in the bottom right of each panel is the number of genes whose expression does not change with selection. Genes whose expression changes upon positive (+) or negative (-) selection are shown for each cell type. (B) Heat diagrams show the relative expression pattern of genes significantly changed in 2 out of 3 replicates in 3A on arrays of purified cell subsets from Figure 1A. Red indicates over-expression and green indicates under-expression. (C) Representative flow cytometry profiles for each positively and negatively purified cell type. Putative contaminating cell populations that correlate with the gene expression patterns observed in 3A are ringed (------).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828063-0-1471-2164-8-64-3.jpg" }
000942
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Immunostaining analysis of the effect of BP on the surface interaction of CD44 and MMP-9 in PC3 cell lines. Confocal microscopy analysis of distribution of CD44 (red) and MMP-9 (green) in PC3 cell lines treated with (+, A' to C') or without (-, A-C) pamidronate is shown. Yellow color indicates colocalization of proteins on the cell surface. The results represent one of three experiments performed. Scale Bar-50 μm.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828067-2-1476-4598-6-18-5.jpg" }
000943
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Analysis of the effects of OPN over expression on cell morphology and RANKL expression in PC3 cell lines. A. Indicated PC3 cell lines were photographed using a phase contrast microscope. An increase in multinucleated giant cells was observed in PC3/OPN cells (magnification × 200). B. Immunoblotting analysis of RANKL expression in PC3 cell lines Immunoblotting analysis in protein lysates made from the indicated cell lines was performed with an antibody to RANKL. PC3/OPN cells express greater level of RANKL that PC3 cells. Results shown are a representation of three independent experiments. Bottom panel shows normalization with GAPDH.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828067-5-1476-4598-6-18-6.jpg" }
000944
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Scanning electron micrographs showing morphological variation of bdelloid rotifers and their jaws. Have these asexual animals really diversified into evolutionary species? (Image: Diego Fontaneto)", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828146-0-pbiop0050099pg001.jpg" }
000945
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Electron micrograph of a cross-section of a D. radiodurans tetracoccus (cluster of four cells).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828147-0-pbiop0050108pg002.jpg" }
000946
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "After surgical decompression, hematoma size is demonstrably reduced (arrow) in this sagittal MRI.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828150-0-1471-2253-7-2-5.jpg" }
000947
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Axial reconstruction from a CT scan upon patient arrival show mild prominence of the prevertebral soft tissues, without clinically significant hematoma or encroachment on the airway (large white arrow).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828150-1-1471-2253-7-2-2.jpg" }
000948
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Sagittal T2 weighted MRI with fat saturation techniques revealing marked increase in the prevertebral soft tissue prominence secondary to an enlarging hematoma (large arrow). Note the severe compromise of the oropharyngeal airway (small arrow).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828150-2-1471-2253-7-2-3.jpg" }
000949
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Axial T2 weighted MRI reveals a bi-lobed disc herniation (arrow), with secondary spinal canal encroachment and mass effect on the cervical spinal cord at the C6-7 level.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828150-3-1471-2253-7-2-4.jpg" }
000950
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Sagittal reconstruction from a CT scan upon patient arrival shows mild prominence of the prevertebral soft tissues, without clinically significant hematoma or encroachment on the airway (large white arrow).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_106-PMC1828150-4-1471-2253-7-2-1.jpg" }
000951
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "P-gp inhibition and MDR chemosensitization. In (A), KB-V1 MDR cells were incubated at 37°C for 1 hr with 5 μg/ml doxorubicin alone or in presence of 2.5 μg/ml verapamil or 25 μg/ml RDS 1984. After washing the cells were reincubated again in identical conditions and doxorubicin efflux/retention were analysed in confocal microscopy after 1 h (panel a-c) and 3 hrs (panel d-f). The natural efflux of doxorubicin P-gp mediated is shown in panel a and d, while the doxorubicin retention due to the P-gp drug transport inhibition exerted by verapamil and RDS 1984 is shown in panel b-c (1 h incubation) or e-f (3 hrs incubation). In (B), dose-response cytotoxicity to vinblastine in CEM-VBL100 MDR cells in presence of verapamil (2.5 μg/ml) or 10 μg/ml of the IINs RDS 1974, RDS 1981, RDS 1983 and RDS 1984 is shown. The values (formazan absorbance at 440 nm in ELISA reader) were calculated as % of control cells cultured in presence of IINs only or verapamil. The mean of triplicate measurements is shown; the SD was < 15% of each single value.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828167-1-1742-4690-4-17-3.jpg" }
000952
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "dRASSF Antagonizes Hpo Activity(A) Hpo/Sav and Hpo/dRASSF are two distinct complexes. Hpo-Myc, Sav-HA, and GFP-dRASSF were cotransfected in Kc cells. Anti-Myc, anti-HA, anti-dRASSF, or control (anti-Flag) immunoprecipitates were blotted for GFP-dRASSF, Sav-HA, Hpo-Myc, and phospho-MST1. Hpo interacts with Sav and dRASSF (lane 2). Sav and dRASSF interact only with Hpo and not with each other (lanes 3 and 4). The Hpo fraction bound to Sav is highly phosphorylated (lane 3), and that bound to dRASSF is not (lane 4).(B) dRASSF inhibits Hpo phosphorylation. Kc cells were treated for 4 days with eGFP, dRASSF, or Hpo dsRNAi. The addition of STS 3 hr prior to lysis induced Hpo phosphorylation (lane 1). Western blots were probed with dRASSF, Hpo34, and phospho-MST1 antibodies. In the presence of dRASSF dsRNAi, Hpo phosphorylation increased (lane 2). As expected, the Hpo band disappeared upon Hpo dsRNAi treatment (lane 3).(C) Sav competes with dRASSF to bind Hpo. Kc cell lysates expressing, respectively, HpoKD-Flag, HA-dRASSF, Sav-HA (200 ng), and Sav-HA (400 ng) were mixed, incubated overnight, and immunoprecipitated with Flag antibody. Blots were probed with HA and Flag antibodies. Increasing the amount of Sav displaced dRASSF from HpoKD (compare lanes 5 and 6).(D) The dRASSF phenotype is sensitive to hpo loss of function. The histogram represents the total body weight as a percent of control flies (white). The reduction in body size in dRASSF flies can be partially rescued by removal of one copy of hpo (hpo42–48 allele). ∗p < 0.05 (white n = 80, dRASSFX16/X16 n = 80, FRT42D, hpo42–48/+ n = 80, and FRT42D, hpo42–48/+; dRASSFX16/X36 n = 80).(E–E″′) Sav controls dRASSF protein level. GFP (in green) and Sav were expressed in the posterior half of the wing disc by the engrailed-GAL4 (en-GAL4) driver. A robust reduction of dRASSF staining (in red [E′]) was observed in the en domain. [E″′] shows Sav overexpression in a separate disc.(F–I) dRASSF reduces apoptosis induced by sav and wts coexpression. Shown are scanning electron micrographs of Drosophila heads from GMR::Gal4 control animals (F) or from GMR::Gal4/UAS::dRASSF (G), GMR::Gal4;GMR::sav+wts (H), or (I) GMR::Gal4/UAS::dRASSF;GMR::sav+wts (I). Overexpression of dRASSF inhibits the rough-eye phenotype generated by coexpression of Sav and Wts.See Supplemental Experimental Procedures for exact genotypes. Error bars correspond to standard deviations.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828611-1-gr3.jpg" }
000953
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Tumour-Suppressor Function of dRASSF(A–C, E, and F) Scanning Electron Micrographs of Drosophila heads from control animals (A), animals bearing hpo42–47 clones (B), hpo42–48 clones (C), hpo42–47 clones in a dRASSF loss-of-function background (E), or hpo42–48 clones in a dRASSF loss-of-function background (F). The overgrowth phenotype elicited by the loss of hpo is enhanced by the removal of dRASSF. See Supplemental Experimental Procedures for genotypes.(D) Schematic representation of Hpo protein showing the different mutations used. The hpo42–47 allele causes a deletion of six amino acids in the kinase domain, and this deletion probably inhibits Hpo-ATP binding. The hpo42–48 allele is a deletion of 20 bp and gives rise to a premature stop codon. hpoKC203 changes G to A at the 5′ splicing site and the translation run into a stop codon in the intron.(G–H″) dRASSF rescues Ras1 loss of function. (G–G″) Ras1c40b clones (marked by a lack of GFP) are small. (H–H″) Rasc40b dRASSFX36 clones (marked by a lack of GFP) are larger than Rasc40b clones. dRASSF staining is in red (G′ and H′).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828611-2-gr4.jpg" }
000954
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Hpo Interacts with dRASSF and Controls Its Expression Levels(A) Hpo coimmunoprecipitates with dRASSF. Endogenous dRASSF was immunoprecipitated from Kc cells lysates with dRASSF antibodies or control (Myc antibodies). The Membrane was blotted with Hpo66 and dRASSF antibodies.(B) Hpo coimmunoprecipitates with dRASSF in Kc cells. Hpo-Flag and GFP-dRASSF were cotransfected in Kc cells. dRASSF or control (Myc antibodies) immunoprecipitates were blotted for GFP-dRASSF and Hpo-Flag.(C) Hpo lacking its SARAH domain (HpoΔC) does not interact with dRASSF. HpoΔC-Flag and GFP-dRASSF were cotransfected in Kc cells. Anti-dRASSF or control (anti-Myc) immunoprecipitates were blotted for GFP-dRASSF and Hpo-Flag.(D) Hpo controls dRASSF and Sav protein levels. Kc cells were treated with GFP, Hippo, Sav, or dRASSF dsRNAs. Lane 5 cells were treated with GFP dsRNA and 3 hr of Staurosporine (STS). Protein extracts were blotted with dRASSF, Hpo66, Sav, P-MST1, and tubulin antibodies. Hpo RNAi strongly reduces both Sav and dRASSF protein levels. dRASSF RNAi stabilizes Sav but is not sufficient to induce Hpo phosphorylation.(E) Hpo loss of function had no effect on dRASSF mRNA expression. RT-PCRs performed on Kc cell lysates treated with GFP or Hpo RNAi. Hpo, dRASSF, and Actin mRNA levels are shown.(F–F″) Hpo controls dRASSF protein levels in vivo. hpo mutant clones (marked by a lack of GFP) were generated in eye discs via the hpo42–48 allele. A robust reduction of dRASSF staining (in red [F′]) is observed in hpo clones.(G–G″) Ex does not affect dRASSF protein levels. Clones of ex mutant cells (marked by a lack of GFP) were generated in eye discs via the exe1 allele. dRASSF (in red [G′]) staining is unaffected in the clones.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828611-3-gr2.jpg" }
000955
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Serial killing by an NK cell. (A) A single NK cell makes multiple contacts with tumor cells resulting in lysis of tumor cells. Dye-labeled IL-2 activated NK cells (N, red) were incubated with unlabelled 221 tumor cells at an E∶T ratio of 0.2∶1 for 16 hours at 37°C and 5% CO2 and images were recorded by time lapse microscopy. Dead cells were detected using Sytox Green and numbered in the order of lysis. Time (h:mm) is indicated in the upper left corner of each image. (B) Majority of conjugate formations result in lysis. Conjugate formations between NK and 221 cells were randomly selected and lysed target cells counted. To rule out the possibility of interference of dyes in killing process, a control 51Cr release assay was performed with labeled cells. No difference was noted between the killing ability of labeled and unlabeled cells (data not shown).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828617-0-ponep0000326pg002.jpg" }
000956
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Transplanted human neural progenitors express nestin in vivo and partially preserve host cone structure. Confocal images of P150 dystrophic retina transplanted with hNPCctx–GDNF and double stained with antibodies against human nuclear antigen (red) and either (A) recoverin, a photoreceptor and cone bipolar cell marker (green), or (B) protein kinase Cα (PKCα), a bipolar cell marker (green). Down arrows point to subretinal donor cell nuclei in panel B, while up arrows point to preserved dendrites of host rod bipolar cells. Note the location of donor cell nuclei in both the inner retina and subretinal space. (C) Confocal image of P150 dystrophic inner retina transplanted with hNPCctx–GDNF and double stained with antibodies against nestin, a neural stem and progenitor cell marker (green) and human nuclear antigen (red). (D) Confocal image of non-dystrophic, control retina stained with cone arrestin antibody (red) showing a normal cone photoreceptor profile (IS: inner segments; ax: axon; arrows point to cone pedicles). (E) P150 dystrophic retina transplanted with hNPCctx–GDNF and stained with cone arrestin antibody showing morphology of rescued cone photoreceptors (arrows point to cone pedicles). (F) Sham-operated retina at P150 stained with cone arrestin antibody (arrows point to rare remaining cone cell bodies). Results at P150 from retina transplanted with hNPCctx were similar to those receiving hNPCctx–GDNF. IPL: inner plexiform layer; ONL: outer nuclear layer; RGC: retinal ganglion cell layer; RPE-L: RPE-like layer.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828619-1-ponep0000338pg006.jpg" }
000957
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Human neural progenitors survive as two distinct populations within the retina and promote photoreceptor rescue. (A) Retinal section obtained from a P150 eye immunostained with human-specific nuclear marker. There is a pigmented RPE-like (RPE-L) layer of donor cells above the host RPE layer, whereas donor cells in the inner retina do not have pigment granules (right-pointing arrows). (B) High power image showing pigment granule-containing donor cells in the RPE-L region that are positive for human nuclear marker (arrows). Photoreceptor inner segments (IS) are visible above the pigmented donor cell layer, demonstrating partial preservation of photoreceptor structure. (C) Retinal section from the same eye used in panel A stained with proliferating cell nuclear antigen (PCNA) revealing occasional dividing cells in the RPE-L layer and inner retina at P150 (arrows). (D) High power image showing PCNA-positive cells in the RPE-L layer (arrows). (E) Low power view of a retina section obtained from the same eye used in panel A showing extensive rescue of photoreceptors within the outer nuclear layer (ONL) after subretinal injection of hNPCctx–GDNF. The boxes labeled f and g correspond to the high power images depicted in panels F and G, respectively. (F) High power view of box f from panel E showing rescued ONL and the underlying, semi-continuous layer of donor cells between the photoreceptors and RPE (arrow). (G) High power view of box g from panel E showing non-rescued ONL distant from surviving subretinal donor cells. INL: inner nuclear layer; IS: inner segments; ONL: outer nuclear layer; RGC: retinal ganglion cell layer; RPE-L: RPE-like layer.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828619-4-ponep0000338pg005.jpg" }
000958
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Ultrastructural aspects of the late steps of Mimivirus replication cycle - capsid assembly.(A) At 8 h p.i. the virus factory (VF) appeared composed of a dense replication centre surrounded by new viral particles. Nu : cell nucleus; bar = 5 µm. (B) At 12 h p.i. the cell cytoplasm was filled with newly synthesised viruses. The cell nucleus (Nu) was expelled to the periphery; bar = 3 µm. (C–G) Pictures were taken at 8, 12 or 16 h p.i. (C) Different stages of viral particles morphogenesis from the replication centre : beginning of hexagonal capsid assembly (white and black arrowheads); complete empty capsid (thick closed black arrow); filling of empty capsids with condensed electron dense material (thick open black and white arrows); release of full closed viral particles surrounded by fibrils at the periphery of the virus factory; bar = 500 nm. (D–G) Different aspects of viral capsid assembly : beginning of capsid assembly (D bar = 500 nm; G bar = 100 nm); almost complete capsids detaching from the replication center (E bar = 100 nm; F bar = 200 nm); complete capsid being filled with electron dense material (F) or complete viral particle without fibril (G). Membranes were observed beneath the capsid layer (F, G long black arrow). The vertex (small black arrows) was on the external side, opposite to the attachment and filling side (C–G).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828621-1-ponep0000328pg002.jpg" }
000959
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Ultrastructural aspects of the late steps of Mimivirus replication cycle – encapsidation of viral DNA.Pictures were taken at 8, 12 or 16 h p.i. (A) Different stages of capsid assembly and DNA encapsidation : complete empty capsid (arrowhead); progressive stages of viral DNA insertion (black arrows) through a portal opposite to the vertex (white arrows); bar = 500 nm. (B) Viral DNA insertion into a capsid (arrowhead) and two different detaching steps of full complete viruses from the replication centre (arrows); bar = 500 nm. (C) Higher magnification of the complete viruses seen in B; bar = 200 nm; (D) Insertion of condensed viral DNA into a viral capsid; bar = 200 nm.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828621-2-ponep0000328pg003.jpg" }
000960
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Mimivirus infectious cycle.\nMimivirus infected A. polyphaga were stained with DAPI at different times points p.i. and representative pictures are shown. A, B : non infected amoebae; C, D: 0 h p.i. Mimivirus particles inside the cytoplasm and near the cell nucleus could be seen; E, F: 4 h p.i. The heterogeneous structure of the VF appeared near the cell nucleus. No viral particles were detectable in the cytoplasm; G, H : 8 h p.i. The intensively stained VF appeared as an homogeneous structure and neosynthesized viral particles accumulated around the VF; I, J : 18 h p.i. The VF was still intensely stained with quite a different structure, whereas the cell cytoplasm was completely filled with new viral particles. Fluorescence (left column) and DIC (right column) images of the same slide field were taken with a 63×/1.4 oil lens. Fluorescence pictures were taken with an exposure time of 1 sec (A) and 64 msec with gain 2 (C, E, G, I). Inset pictures corresponded to the same as E, G and I taken at a different exposure time 64 msec (E, G) and 16 msec respectively (I).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828621-3-ponep0000328pg004.jpg" }
000961
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Ultrastructural aspects of the early steps of Mimivirus replication cycle.Transmission electron microscopy pictures were taken at 0 h p.i. (A–C) or at 4 h p.i. (D–L). (A) Mimivirus particle being phagocytosed by an amoeba; bar = 2 µm. (B) Several single viral particles within intra-cytoplasmic vacuoles; bar = 2 µm. (C) Higher magnification of the boxed area in B showed the open vertex of an empty particle (arrow); bar = 1 µm. (D) Close contact of the membranes of two vacuoles (arrow), one with several Mimivirus particles and the other with a single viral particle; bars = 1 µm. (E) Extrusion of the internal Mimivirus membrane toward the vacuole membrane; bar = 200 nm. (F) Higher magnification of the contact zone between viral and vacuole membranes (arrow); bar = 100 nm. (G) Full closed, empty with open vertex (arrow) and opening Mimivirus particles; bar = 500 nm. (H) Higher magnification of the opening Mimivirus particle in G. The fused viral and vacuole membranes were clearly visible (arrow); bar = 100 nm. (I) Condensed electron dense material inside the cell nucleus (arrow); bar = 2 µm. (J) Higher magnification of the condensed electron dense material between the nuclear membrane and the nucleolus (arrow); bar = 500 nm. (K) An electron dense structure (arrow), distinct from the cell nucleus was observed; bar = 5 µm. (L) Higher magnification of this heterogeneous structure, surrounded with mitochondria; bar = 200 nm.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828621-5-ponep0000328pg001.jpg" }
000962
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Interaction of DCs with Naïve CD4+ T CellsiDCs expressing MHCII-GFP and CFSE-labeled CD4+ T cells were used for live cell imaging of DC/T-cell immune interactions. Live fluorescent confocal microscopy imaging was performed at 4 h of LPS treatment. CD4+ T cells are indicated by a “T”.(A) DCs left untreated.(B) iDCs were pulsed for 30 min with Sp1 (500 μg/ml) and then treated with LPS. Scale bar, 10 μm.(C) iDCs were treated with Sp1 (100 μg/ml) for 45 min or left untreated before incubation with naïve CD4+ T cells in the presence of LPS (100 ng/ml). CD69 surface expression on CD4+ T cells was analyzed at indicated time points. Black line, non-Sp1-treated DCs; gray line, Sp1-treated DCs.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828696-0-ppatp0030032pg004.jpg" }
000963
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Export of Sp1 from Lysosomes to the Cell Membrane in MHCII-GFP–Positive Tubular Structures in Live DCs(A) iDCs transfected with MHCII-GFP were treated for 30 min with Sp1-Alexa 594 (500 μg/ml) and then analyzed by live cell imaging using confocal microscopy. In merged fluorescence images, Sp1 co-localizes extensively with MHCII in lysosomes. No MHCII is found on the cell surface.(B) iDCs transfected with MHCII-GFP were pre-incubated for 30 min with Sp1-Alexa 594 (500 μg/ml) and then treated with LPS for 4 h. Merged fluorescence live cell images of confocal microscopy demonstrate that Sp1/MHCII-positive tubular structures emanate from lysosomes in a perinuclear region and transit to the cell membrane. A single translocation Sp1/MHCII-positive tubule is labeled with white arrows (see Video S1).(C) iDCs previously transfected with MHCII-GFP and pre-incubated for 30 min with Sp1-Alexa 594 (500 μg/ml) were stimulated for 4 h with LPS. Combined TIR-FM/EPI microscopy reveals exit of Sp1-containing tubules from lysosomes (red) and their association with the plasma membrane (bright yellow). Tubules are labeled with white arrows (see Video S2). Scale bar, 10 μm.(D) After treatment with Sp1-biotin for 30 min, iDCs were incubated for various time intervals with LPS, and their cell surface was stained with FITC-conjugated streptavidin. Presentation of Sp1-biotin on the DC surface was quantified by flow cytometry.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828696-1-ppatp0030032pg003.jpg" }
000964
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "DCs in Intraabdominal Abscess Formation Induced by Sp1(A) Twenty-four hours after intraperitoneal Sp1 challenge, cells of the peritoneal influx were stained with phycoerythrin (PE)–conjugated anti-CD11c mAb to stain DCs, and analyzed by flow cytometry. Numbers in the right quadrant of the right dot blot represent the percentage of CD11c-positive cells gated as indicated in the left dot blot and non-gated cells, respectively. FSC-H, forward scatter; SSC-H, sideward scatter.(B) Immunohistology of abscesses was performed with anti-CD11c mAb. One single CD11c-positive cell in the abscess wall is labeled with a black arrow.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828696-5-ppatp0030032pg001.jpg" }
000965
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "DM Dependency of Sp1 Retrograde Transport in MHCII-Positive Tubules(A) DM−/− iDCs transfected with MHCII-GFP were treated for 30 min with Sp1-Alexa 594 (500 μg/ml) before live cell imaging by confocal microscopy. Merged fluorescence images of DM−/− iDCs reveal co-localization of Sp1 with MHCII-GFP in lysosomes. No MHCII is found on the cell surface.(B) DM−/− iDCs transfected with MHCII-GFP were pre-incubated with Sp1-Alexa 594 (500 μg/ml) for 30 min and then treated with LPS for 4 h. Merged fluorescence live cell images of confocal microscopy demonstrate that DCs form MHCII-GFP–positive tubules by 4 h of stimulation with LPS that extend from the perinuclear area to the cell surface (arrows) while Sp1-Alexa 594 remains lysosomal (right panel). Scale bar, 10 μm.(C) DCs from WT or DM−/− mice expressing MHCII-GFP were stimulated with Sp1-Alexa 594 (500 μg/ml) for 30 min and LPS for various time intervals. Immune interactions with CFSE-labeled WT T cells were analyzed by live cell fluorescent microscopy imaging (see also Figure 2E and 2F).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828696-6-ppatp0030032pg007.jpg" }
000966
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Dynorphin Binds to P. aeruginosa In Vitro, and Enters the Bacterial Cell Cytoplasm(A–C) Binding of dynorphin to P. aeruginosa; (A) negative control demonstrating no dynorphin staining when cells were not incubated with dynorphin; (B) negative control demonstrating no dynorphin staining when cell were incubated with dynorphin but primary anti-dynorphin antibodies were omitted from staining procedure; and (C) positive staining (brown color) of P. aeruginosa incubated with dynorphin followed by whole procedure of immunostaining.(D) Immunoelectron microscopy of P. aeruginosa PAO1 cells incubated with dynorphin, 100 μM. Black arrows show 10-nm gold spots indicating the presence of dynorphin.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828698-1-ppatp0030035pg006.jpg" }
000967
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "In Vivo Production of Dynorphin in the Mouse Intestine during I/R(A–C) Histology of small intestine from (A) control mice demonstrating intact mucosal epithelium, and (B) I/R and (C) I/R + Pa mice showing disruption of mucosal epithelium with desquamated epithelial cells inside the intestinal lumen (black arrows).(D–F, G–I) Immunohistochemistry of the small intestine from (D and G) control mice demonstrating scarce dynorphin localized to the epithelial crypt (brown staining, red arrow), and following (E and H) I/R and (F and I) I/R + Pa showing dynorphin migration up the lamina propria (red arrows, [E]) and its accumulation on villi and within the lumen. Scale bars are in μm.(J–M) Images of luminal bacteria from mouse small intestine subjected to I/R + Pa demonstrating (J) transfer of dynorphin to bacteria (brown-colored bacteria) and (K) positive dynorphin stained bacteria bound to desquamated epithelia; (I) abundant epithelial dynorphin staining (red arrow), and (M) co-localization of dynorphin stained luminal bacteria to sites of dynorphin accumulation at the epithelial surface. Scale bars are in μm.(N) Concentration of dynorphin in filtered luminal flushes isolated from intestine of control mice and mice subjected to I/R and I/R + Pa. n = 10/group, * p <0.001.(O) Correlation analysis between dynorphin concentration in luminal flushes and their ability to induce PCN production in PAO1.(P) Effect of dynorphin depletion with anti-dynorphin antibody on the ability of luminal flush samples to produce PCN in PAO1, n = 6/group, * p <0.005. Error bars, mean ± SD.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828698-5-ppatp0030035pg005.jpg" }
000968
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Lithium Chloride and Glycerol Treatments Influence Capsule Size(A) Sensitivity of the WT strain H99 and the pka1 and pkr1 mutants to growth on YPD medium containing LiCl. The strains are listed on the left side of the panel. The plates were incubated at 30 °C or 37 °C for 5 d before being photographed.(B) Sixty cells from the WT (H99) strain treated with LiCl at the indicated concentrations were measured for cell diameter and capsule radius. Each bar represents the average of measurements for 60 cells. The capsule sizes of the cells treated with 10, 30, and 75 mM LiCl were statistically different (p <0.001) from the sizes for the untreated cells.(C) Examination of capsule formation in the WT strain, and the pkr1 and ova1 mutants, in a range of LiCl concentrations. Bar = 10 μM.(D) Capsule formation in the WT and the pkr1 and ova1 mutants in the presence of glycerol at two concentrations (5% and 10%). Bar = 10 μM. In (B–D), cells were cultured in LIM at 30 °C for 16 to 72 h with addition of glycerol or LiCl as indicated.(E) Sixty cells from the WT (H99) strain grown with the indicated concentrations glycerol were measured for cell diameter and capsule radius. Each bar represents the average of 60 measurements. The capsule sizes of the cells with either concentration of glycerol were statistically different (p <0.001) from the sizes for the untreated cells.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828699-9-ppatp0030042pg003.jpg" }
000969
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Higher power magnification of figure 6 showing moderate to strong nuclear for s100p, DAB, Hx, × 40.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828714-0-1746-1596-2-9-7.jpg" }
000970
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "High proliferation fraction as noted by the staining of up to 75% of the neoplastic lymphocytes, MIB-1, DAB, Hx, × 10.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828714-1-1746-1596-2-9-9.jpg" }
000971
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Higher power magnification of figure 9 showing strong nuclear staining of the neoplastic lymphocytes, MIB-1, DAB, Hx, × 40.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828714-2-1746-1596-2-9-10.jpg" }
000972
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Bcl-2 membranous staining of the neoplastic lymphocytes, DAB, Hx, × 40.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828714-3-1746-1596-2-9-8.jpg" }
000973
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Centroblastic polymorph variant on H&E staining, × 40.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828714-5-1746-1596-2-9-1.jpg" }
000974
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "CD79a membranous staining of the lymphocytes, DAB, Hx, × 40.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828714-6-1746-1596-2-9-2.jpg" }
000975
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Higher power magnification of figure 4 showing moderate nuclear and rare cytoplasmic SMA staining of the neoplastic lymphocytes, DAB, Hx, × 40.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828714-7-1746-1596-2-9-5.jpg" }
000976
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "SMA staining showing positivity of the lymphocytes and internal control of the blood vessels, DAB, Hx, × 10.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828714-8-1746-1596-2-9-4.jpg" }
000977
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Showing the extent of injury.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828716-0-1749-799X-2-4-1.jpg" }
000978
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Dorsal aspect of the middle finger after free thenar flap, 6 months postop.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828716-3-1749-799X-2-4-5.jpg" }
000979
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Showing the blue print of the flap area and the pedicle.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828716-4-1749-799X-2-4-2.jpg" }
000980
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Custom-build silicon pressure splint for the left helical rim.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828721-1-1746-160X-3-14-2.jpg" }
000981
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Influence of irradiation on the stem cell population as shown by macpiwi expression in Macrostomum. (A) Macpiwi expression in control adult. Signal was present in testes (t), ovaries (o), developing eggs (de) as well as at a basic level in somatic stem cells. (B) Expression of macpiwi in somatic stem cells 3 hours postirradiation. (C) After 1 day recovering from irradiation, macpiwi expression in somatic stem cells is lacking, but present in the gonads. (D) Macpiwi expression 1 week postirradiation (80 Gray). Note the complete loss of macpiwi expression in testis. (E) Macpiwi expression resembles default expression pattern 3 weeks postirradiation (80 Gray). scalebar 100 μm.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828727-2-1742-9994-4-9-5.jpg" }
000982
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Treatment of Macrostomum lignano with Hydroxyurea. (A) Non-treated control animal with BrdU-labeled S-phase cells arranged in two lateral bands (arrowheads). (e) alg remnants of digested food algae showing red autofluorescence, tp tail plate. (B) BrdU stainings of M. lignano treated with 2.5 mM Hydroxyurea for 8.5 days. Specimen shows about 10 BrdU-labelled cells in S-phase (arrowheads). Some background can be seen in the pharynx glands (pg) and the female genital opening (fgo). tp tail plate. scalebar 100 μm. (C) In situ hybridization of control animal with macvasa. Signal present in male (t testes) and female gonads (ov ovaries) and developing eggs (de). e eyes, tp tail plate. (D) In situ hybridization with macvasa after 11 days of HU-treatment. Only female gonads (ov ovaries) show signal. Male gonads (t testes) show no expression of macvasa. e eyes, de developing eggs, ov ovaries, t testes, scalebar 100 μm.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828727-4-1742-9994-4-9-3.jpg" }
000983
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "(a): Histology of benign granular cell tumor of the bladder of patient 1 (haematoxylin and eosin stain ×100); b): Histology of benign granular cell tumor of the bladder of patient1 (haematoxylin and eosin stain ×100); c): Immunohistochemical staining of benign granular cell tumor of the bladder of patient 1. (S-100 stain) Note positive staining of cell nucleus and cytoplasm. (×100).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828733-0-1477-7819-5-33-1.jpg" }
000984
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "(a): Histology of malignant granular cell tumor of the bladder of patient 2 (haematoxylin and eosin stain). Note infiltration of tumor cells into the smooth muscle. (×100); b): Histology of malignant granular cell tumor of the bladder of patient 2 (haematoxylin and eosin stain). The cells exhibit abundant pink granular cytoplasm. Note prominent nucleoli in majority of cells. (×100);", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828733-1-1477-7819-5-33-3.jpg" }
000985
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "CT scan of the abdomen/pelvis at 4 months post op showing a normal-looking bladder with right double J stent in place.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828733-2-1477-7819-5-33-2.jpg" }
000986
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Immunohistochemical staining of tissue microarray cores with MUC1 and MUC3 antibodies. A & B show cores from tumour demonstrating positive (A) and negative (B) MUC1 staining. C & D show cores of tumour demonstrating strong (C) and weak MUC 3 staining. All are at × 100 magnification.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1828734-0-1477-7819-5-31-1.jpg" }
000987
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "A three-chamber view showing a combination of 2 different flow jets, one in the mid of left ventricle and the other in the outflow tract.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829155-0-1476-7120-5-12-2.jpg" }
000988
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Short-axis view at end diastole showing an asymmetric type hypertrophic cardiomyopathy with extreme hypertrophy of the anterior septum.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829155-1-1476-7120-5-12-1.jpg" }
000989
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Reactivity of the hybridomas GCTM-2 and TG30 used to fractionate hESC by flow cytometry. A, Protein lysate from M15 cells transfected (T) with the full-length human podocalyxin construct, pcDNA3/Podxl, shows immunoreactivity to podocalyxin antibodies (PHM5). In contrast, no immunoreactivity was observed with GCTM-2, TG343 or TRA 1–60 antibodies, nor in the untransfected (UT) cells. B, Indirect immunofluorescent staining of hESC for podocalyxin (green) and GCTM-2 (red). C, Human kidney stained for GCTM-2. D, Human kidney stained for podocalyxin. E, Mouse STO cells transfected with human CD9 cDNA stained by indirect immunofluorescence for CD9 (red) and TG30 (green) and DAPI (blue). CD9 and TG30 staining is entirely coincident. Bar in B-E = 100 μm.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829156-3-1471-213X-7-12-1.jpg" }
000990
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Coronal fat-suppressed T2-weighted magnetic resonance image of the left shoulder revealing diffuse synovitis and bursitis with a large joint effusion. Numerous loose bodies representing rice bodies and degenerative cystic changes within the humeral head were also present (arrow).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829162-0-1471-2334-7-9-2.jpg" }
000991
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Left chest and shoulder, with arrow indicating site of prior injection into or near the acromioclavicular joint. Insert: Close-up view of area indicated by arrow.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829162-1-1471-2334-7-9-1.jpg" }
000992
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "CD10 and CD13 prostate cancer cell types. Positive staining is indicated by the brown chromogen deposit. Non-cancer glands are generally positive for both CD10 and CD13. In the left and middle cases the tumors consist of small crowded glands in the left half of the field. Most of the cancer glands are CD10- and CD13+, although a few isolated CD10+ cancer glands can be seen. In the right case, a subpopulation of CD13+ cancer cells are present in the larger population of CD10-/CD13- cancer cells. This tumor shows no glandular morphology. Magnification is 20×.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829163-6-1471-2490-7-3-1.jpg" }
000993
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "CD10 immunohistochemistry of prostate cancer lymph node metastasis. Positive staining is indicated by the brown chromogen deposit. Magnification is 40×.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829163-7-1471-2490-7-3-7.jpg" }
000994
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Immunohistochemical staining for CD56, Syn, CK, and EMA in the combined SCC case. CD56 (A) and Syn (B) immunopositivity was observed in the SCC area, and CK (C) and EMA (D) immunopositivity was observed in the regions of squamous cell carcinoma (Mag. × 400).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829164-0-1471-2407-7-38-2.jpg" }
000995
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Hematoxylin and eosin-stained sections showing morphology of esophageal SCC morphology. Nested or organoid growth pattern was the most common (A). Sheet-like growth was a dominant pattern in 3 cases (B). In one case, we observed marked cellularity similar to lymphoma (C). Combined SCC of the esophagus with well-differentiated squamous cell carcinoma (D). (Mag. × 400).", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829164-1-1471-2407-7-38-1.jpg" }
000996
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "Dendritic stratification pattern of RGCs in Thy-1 mGFP mice.(A) Confocal image of an RGC from whole-mount retina of a mGFP mouse. GFP expression is enhanced with a specific immunostaining. Immunostaining with anti-GFP antibody shows that RGC somata, dendrites and axons are GFP-positive [scale bar = 50 µm]. (B) Schematic representation of the patterning of cholinergic amacrine cell projections (red), which identify the a and b sublaminae of the IPL. An ON- and an OFF-center RGC, with dendrites monostratified in the b or a sublaminae, respectively, and an ON-OFF bistratified RGC are drawn in green. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer. (C, D, E): Top row: examples of RGC (green) confocal reconstructed maximum projection images taken from whole-mount retinas from P16 mGFP mice; bottom row: 90 degrees rotation images of the cells displayed above. Red label denotes the immunolabeling pattern of Choline Acetyltransferase (ChAT) positive amacrine cells. Confocal microscopy was used to produce stacked images of three-dimensional reconstructed GFP-expressing RGCs and of ChAT positive amacrine cells. ChAT positive cell bodies are respectively in the GCL and in the INL, while their projections form two bands clearly visible in the rotated images (white arrow heads) that run along the sublamina a and b of the IPL. Bistratified RGCs present a double-layered segregated arborization with respect to the two anti-ChAT labeled bands (C, bottom), while monostratified ganglion cells have their dendrites proximal to the cell body and restricted to the ChAT positive band within sublamina b (D, bottom) or distal to the cell body and restricted to the outermost ChAT positive band in sublamina a (E, bottom) [scale bars = 50 µm]. (F, G, H) Examples of RGC (green) confocal images taken from 25 µm vertical retinal sections from P30 mGFP mice. The red bands representing the projections of cholinergic amacrine cells immunolabeled with ChAT, which denote the sublaminae of the IPL, are pointed at with white arrow heads [scale bar = 50 µm].", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829175-0-ponep0000346pg001.jpg" }
000997
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "BDNF mediates the effects of EE on RGC dendritic segregation.(A) Examples of an ON-OFF RGC (left), an ON RGC (center), an OFF RGC (right) in retinal vertical sections of P16 EE antisense treated mice (top row) or sense treated mice (bottom row) (scale bar: 50 µm). Conventions as for Fig. 1. (B) Average percentage of bistratified RGCs in P16 non-EE mice (white), untreated EE mice (control, black), EE mice treated with BDNF antisense (antisense, vertical line-pattern) and EE mice treated with BDNF sense (sense, horizontal line-pattern). In the retinas of EE mice injected with BDNF antisense oligos (N = 5) the percentage of bistratified RGCs is similar to that of normal non-EE mice of the same age (51,9±2,5%, 43/84 cells versus 53,8±3,2%, 91/169 cells), whereas the control treatment with sense oligos (N = 5) has no effect on the accelerated development produced by EE (32,2±3,5%, 29/88 cells versus 36,9±5,2%, 31/81 cells in EE mice treated with BDNF sense oligos and EE untreated mice, respectively). One Way ANOVA indicates a statistical difference (asterisks) between control EE and antisense treated EE, between sense and antisense treated EE mice and between non-EE and control or sense treated EE mice; no difference is found between untreated (control) and sense treated EE mice and between non-EE and antisense treated EE mice (p = 0,001; post-hoc Tukey's test). The bars indicate SEM. The blockade of BDNF expression blocks the effects of EE on RGC dendritic stratification.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829175-1-ponep0000346pg006.jpg" }
000998
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar
{ "caption": "High-resolution TEM (HRTEM) and selected-area electron diffraction (SAED) characterization of uranium-loaded periplasm of the DL1 and DL1-MacA strains. A. representative SAED pattern from the cell wall displaying diffuse diffraction rings. Average scattering distance measured from the first diffraction ring is 2.2 Å; B and C – High magnification bright-field (BF) and dark-field (DF) TEM images of the cell wall of the strain DL1-MacA; D and E – BF and DF TEM images of the cell wall of the strain DL1; F and G – High-resolution TEM image of the cell wall of the strains DL1-Mac-1(F) and DL1 (G), showing amorphous features of the U-bearing cell wall layers. OM – outer membrane, P – periplasm, IM – inner membrane.", "subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_107-PMC1829397-2-1471-2180-7-16-6.jpg" }
000999
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00000.tar