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16,719,310 |
{
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"ArXiv": null,
"DOI": "10.1145/800144.804752",
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|
This paper describes an educational version of the SAC-1 list processing system. Educational systems such as WATFIV, WATBØL, and PL/C are available for teaching programming languages. However, the authors could find no comparable systems for list processing. Since such facilities would be useful in many courses (e.g., data structures, operating systems, symbol manipulation), EDUSAC was developed.
|
2022-09-14T05:30:48.401Z
|
117,400,012 |
{
"externalids": {
"ACL": null,
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"DOI": "10.4283/JMAG.2002.7.4.138",
"MAG": "1570630000",
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|
Magnetic properties, microstructure and texture of NdFeB magnets fabricated by a modified hot working process from commercial melt-spun powders (Magnequench; MQPA, MQPB and MQPB+) have been investigated. The hot-pressed isotropic magnet made from MQPA powder, which contains higher Nd content than that of MQPB or MQPB+, shows higher coercivity. The magnet also shows homogenous and fine grains with higher coercivity for higher consolidation pressure. The hot-deformed MQPA magnet shows a strong anisotropy along the press direction with homogeneous platelet Nd₂Fe₁₄B grains of 50~100 ㎚ in thickness and 200~500 ㎚ in length. The hot-deformed MQPB+ magnet, however, shows low remanence and low coercivity. The microstructure of the magnet consists of two areas; undeformed Nd₂Fe₁₄B grains and well-aligned but large grains with 3~4 ㎛ in length. Low Nd content attributes to the formation of the two different area.
|
2022-09-06T14:24:48.518Z
|
144,002,012 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5539/ASS.V10N2P37",
"MAG": "2000870683",
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"license": null,
"status": null,
"url": null
}
|
The purpose of this qualitative study was to investigate drug offense recidivism among female inmates for which data were collected from in-depth interviews with 18 female inmates of Nakhon Si Thammarat Central Prison, and informal interviews with prison officers or warders. Logical context description was employed to analyze content by comparing theoretical concepts with other related studies.The findings of the study revealed that the recidivism among female inmates would never end if they still had arduous living conditions with burdens of raising children without help from relatives. Most of them were not well educated and were easily cheated by males who were their boyfriends or husbands. It could be because they wanted love, good future, good family, and a lot of money, so they inevitably chose to commit offenses either with or without intention. Most of the female inmates did not learn their lesson if the penalties were not severe. Some of them were granted a royal pardon, which was deemed the best thing that could happen in the life of any inmate, however, they were not afraid of reoffending-even though whilst in prison they intended not to have anything to do with drugs again. Nevertheless, when they returned to the same environments, their way of life and people around them made them repeat their offenses. The results of this study would be useful for related individuals and organizations in forming policy and designating preventive measures, and solving the problem of recidivism so that inmates would become good people and would not repeat the offenses.
|
2022-10-28T20:29:21.279Z
|
5,824,726 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4156/JCIT.VOL6.ISSUE7.43",
"MAG": "2313149476",
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},
"license": null,
"status": null,
"url": null
}
|
During the last three decades, many software reliability models have been proposed and analyzed for measuring software reliability. Those models are mathematical models that represent software failures as a random process and can be used to evaluate development status during testing. Also they proposed artificial neural network based approach for software reliability estimation and modeling. They already have shown how to apply neural network to predict a dynamic model. In this paper, we propose an improved neural network based dynamic predication model of software reliability, we improve the original model by choosing well-selected data models from all data models. Due to well-selected data models, proposed model improve the predication capability.
|
2022-12-07T21:56:55.816Z
|
234,052,486 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1142/S0129183121500674",
"MAG": "3127996268",
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"status": null,
"url": null
}
|
The motion of a neutrally buoyant circular particle in a parallel double-lid-driven square cavity is studied with the lattice Boltzmann method. To understand, predict and control the motion of the ...
|
2022-12-11T23:41:20.113Z
|
56,766,682 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00325481.1962.11694612",
"MAG": "2340790538",
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|
The two principal factors in precipitation of functional disturbance are quality of individual and quantity of trauma.An erroneous diagnosis of physical illness followed by medical or surgical treatment tends to fix the neurotic state, but the greatest harm occurs when a patient with a conversion reaction dies with an untreated malignant disease.Successful management of functional gastrointestinal disturbance encompasses dietetic therapy, pharmacologic aids, creation of insight, correction of rigid states, reeducation, and adjunctive measures.The comparative effectiveness of various tranquilizers and antidepressants is reviewed, and experience with the nonbarbiturate sedative thalidomide is presented.
|
2022-12-17T12:56:46.271Z
|
71,599,459 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000264940",
"MAG": "1991823794",
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"license": null,
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}
|
Immunosuppression with antilymphocyte globulin (ALG) was administered to 13 patients suffering from ophthalmic diseases. These included 4 with sympathetic ophthalmia, 3 with chronic generalized uveitis, 1 with necrotizing scleritis, 3 with corneal transplantation and 2 with combined corneal and scleral transplants. There was significant improvement in the patients with sympathetic ophthalmia and uveitis when ALG treatment was started early enough, i.e., as long as inflammatory processes were demonstrable. The results achieved in patients given corneal transplants were less convincing in the final outcome, although 3 patients – 2 had rejected previous corneal grafts within weeks – tolerated their corneas for several months after ALG treatment. It was not possible to reverse opacification occurring during corneal graft failure by ALG
|
2022-09-09T11:07:32.357Z
|
53,377,388 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15376/BIORES.3.4.1228-1243",
"MAG": "1671615211",
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}
|
Unmodified and modified rice husk powder filled PVC composites were prepared having different amounts of rice husk powder. Mechanical, thermal, and electrical properties of these composites were determined. The tensile strength of rice husk powder PVC composites having 0, 10, 20, 30, and 40 weight percent of rice husk powder was found to be 33.9, 19.4, 18.1, 14.6, and 9.5 MPa, respectively. Adding of maleic anhydride- modified rice husk powder improved the tensile strength of rice husk powder PVC composites. Flexural strength and flexural modulus of composites increased on treatment of rice husk powder due to the improved bonding between rice husk powder and PVC matrix. Arc-resistance of rice husk powder PVC composites was not affected on increasing loading of the powder. Volume resistivity and surface resistivity decreased with increasing loading due to the presence of impurities and water molecules. Vicat softening temperature increased with rice husk powder loading. Addition of rice husk increased the melting temperature of the composite matrix as compared to pure PVC.
|
2022-11-17T00:39:04.264Z
|
79,555,283 |
{
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"ArXiv": null,
"DOI": "10.1088/1742-6596/884/1/012125",
"MAG": "2752806410",
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"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/884/1/012125"
}
|
Endovenous ablation has been performed for varicose veins of the limbs in Indonesia since 2010. Endovenous laser ablation (EVLA) therapy has been performed in Cipto Mangunkusumo Hospital (RSCM) in Jakarta, and mechanochemical ablation (MOCA) has been conducted in Fatmawati Hospital. This was a descriptive analytical study, with a cross-sectional design to analyze post-ablation recanalization after MOCA and EVLA procedures. Patients who had undergone MOCA or EVLA treatment were interviewed 3–18 months after the procedures. All the patients underwent vascular ultrasonography (USG) of the operated limb to assess recanalization. Secondary presurgery data were obtained from the patients’ from patients’ medical records. The clinical characteristics of the subjects were recorded to compare the potential correlation between these characteristics and recanalization post-MOCA and EVLA procedures. All the data were analyzed using SPSS ver. 20.0. The study consisted of 43 limbs: 24 treated by MOCA and 19 treated by EVLA. Most subjects in the MOCA group were <60 years (20/24), and 16 of the subjects were women. In the EVLA group, nine patients were <60 years, and 19 were ≥60 years, 15 of whom were women. The body mass index (BMI) of the majority (18/24) of the subjects in the MOCA group was normal, whereas most of the patients in the EVLA (10/19) group were overweight. In the MOCA group, the largest diameter of the vena saphena magna (VSM) in 20/24 extremities prior to treatment was VSM 4–7 mm, whereas the largest diameter in the EVLA group prior to treatment was >7 mm in 13/19 extremities. In the MOCA group, total recanalization occurred in 2/24 extremities, and partial recanalization occurred in 8/24 extremities. In the EVLA group, total recanalization occurred in 1/19 extremities, and partial recanalization occurred in 3/19 extremities. The association between the clinical characteristics of the patients and recanalization was not statistically significant (p > 0.05). The recanalization tendency was higher in the MOCA group than in the EVLA group. Although there was no statistically significant association between the clinical characteristics of the patients and recanalization, the largest diameter of the VSM presurgery (>7 mm) was higher in 3/4 extremities in the MOCA group, as compared to 3/13 extremities in the EVLA group.
|
2022-11-18T01:06:03.701Z
|
2,986,407 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1161/CIRCULATIONAHA.108.823609",
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|
Background— The challenge of angiogenesis science is that stable sustained vascular regeneration in humans has not been realized despite promising preclinical findings. We hypothesized that angiogenic therapies powerfully self-regulate by dynamically altering tissue characteristics. Induced neocapillaries increase drug clearance and limit tissue retention and subsequent angiogenesis even in the face of sustained delivery. Methods and Results— We quantified how capillary flow clears fibroblast growth factor after local epicardial delivery. Fibroblast growth factor spatial loading was significantly reduced with intact coronary perfusion. Penetration and retention decreased with transendothelial permeability, a trend diametrically opposite to intravascular delivery, in which factor delivery depends on vascular leak, but consistent with a continuum model of drug transport in perfused tissues. Model predictions of fibroblast growth factor sensitivity to manipulations of its diffusivity and transendothelial permeability were validated by conjugation to sucrose octasulfate. Induction of neocapillaries adds pharmacokinetic complexity. Sustained local fibroblast growth factor delivery in vivo produced a burst of neovascularization in ischemic myocardium but was followed by drug washout and a 5-fold decrease in fibroblast growth factor penetration depth. Conclusions— The very efficacy of proangiogenic compounds enhances their clearance and abrogates their pharmacological benefit. This self-limiting property of angiogenesis may explain the failures of promising proangiogenic therapies.
|
2022-12-11T15:18:59.700Z
|
205,723,776 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1537-2995.2010.03002.x",
"MAG": "1930313974",
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},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc3250225?pdf=render"
}
|
BACKGROUND: Blood centers are interested in understanding determinants of frequent blood donation. We hypothesized that participation in uncompensated research could result in higher donation rates.
|
2022-12-13T02:05:32.743Z
|
128,826,858 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/98JB02794",
"MAG": "1999610203",
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"license": null,
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"url": null
}
|
Interferometric synthetic aperture radar (INSAR), like other astronomic and space geodetic techniques, is limited by the spatially and temporally variable delay of electromagnetic waves propagating through the neutral atmosphere. Statistical analysis of these variations, from a wide variety of instruments, reveals a power law dependence on frequency that is characteristic of elementary (Kolmogorov) turbulence. A statistical model for a major component of the delay fluctuations, the “wet” component, has previously been developed by Treuhaft and Lanyi [1987] for very long baseline interferometry. A continuous Global Positioning System (GPS) network is now in place in southern California that allows estimation of, along with geodetic parameters, the total delay due to the atmosphere above each site on a subhourly basis. These measurements are shown to conform to the Treuhaft and Lanyi (TL) statistical model both temporally and spatially. The TL statistical model is applied to the problem of INSAR and used to produce the covariance between two points separated in time and/or space. The error, due to the atmospheric variations, for SAR products such as topography and surface deformation is calculated via propagation of errors. There are two methods commonly cited to reduce the effect of atmospheric distortion in products from SAR interferometry, stacking and calibration. Stacking involves averaging independent interferograms to reduce the noise. Calibration involves removing part (or all) of the delay using data from an independent source such as total zenith delay estimates from continuous GPS networks. Despite the relatively poor spatial density of surface measurements, calibration can be used to reduce noise if the measurements are sufficiently accurate. Reduction in tropospheric noise increases with increasing number of measurement points and increasing accuracy up to a maximum of √N, where N is the number of points. Stacking and calibration are shown to be complementary and can be used simultaneously to reduce the noise to below that achievable by either method alone.
|
2022-12-30T18:54:34.319Z
|
7,899,835 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICCAS.2015.7364971",
"MAG": "2395278877",
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"url": null
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|
These days, robust autonomous navigation incorporates the information on the digital map including variety of road features such as position of lane markings, road boundaries and etc. In this study, a method of extracting road features are developed using two dimensional laser range finder (LRF). In particular, range measurements are employed to identify the road surface using split and merge method. In addition, the reflectivity measurements are used to identify lane markings on the road surface. Finally a digital map of road surface is constructed which is useful for robust autonomous navigation. The proposed method is verified using experimental LRF data measured on the road environments.
|
2022-01-27T20:12:31.362Z
|
191,768,406 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.9771/2176-4794ell.v0i52.15465",
"MAG": "2555387624",
"PubMedCentral": null
},
"license": "publisher-specific license",
"status": "GOLD",
"url": "https://portalseer.ufba.br/index.php/estudos/article/download/15465/10612"
}
|
Neste artigo, pretende-se reconstruir os sons constitutivos (mas nao os fonemas) de sistemas linguisticos em seis sincronias que formam a historia da lingua portuguesa. Objetiva-se descrever precisamente, em cada uma, os eventos que de fato ocorreram. Trata-se de uma primeira tentativa de organizar os fenomenos foneticos em sincronias preteritas da Peninsula Iberica, com enfase nas variantes românicas faladas no Noroeste.
|
2022-02-08T08:59:19.320Z
|
149,479,430 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0021223700017660",
"MAG": "2798108648",
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"license": null,
"status": null,
"url": null
}
|
The role of the United States as midwife in the Israeli-Egyptian peace process has become a familiar one in recent years. Indeed, the local protagonists have all but taken for granted that their own peacemaking efforts would be catalyzed and reenforced by the United States. The pattern of American involvement has since 1975–76 had a dual aspect: American personnel have been permanently stationed in Sinai, and U.S. assurances have been extended to the parties (especially to Israel) as inducements to the acceptance of painful concessions. The American presence in Sinai, when initiated in 1975–76, was minimal both in terms of its numbers and its functions. Fewer than 200 U.S. civilians operated the Sinai Field Mission, an early warning system in the strategic Giddi and Mitla mountain passes, whose purpose was to complement the functions of the UN peacekeeping force in the Sinai (the UN Emergency Force or UNEF II).
|
2022-06-23T09:17:17.744Z
|
59,332,981 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5194/HESSD-5-2491-2008",
"MAG": "2016275622",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Geostatistical modeling of spatial variability of water retention curves H. Saito, K. Seki, and J. Šimůnek Department of Ecoregion Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan Faculty of Business Administration, Toyo University, Tokyo 112-8606, Japan Department of Environmental Sciences, University of California, Riverside, CA 92521, USA Received: 1 August 2008 – Accepted: 3 August 2008 – Published: 3 September 2008 Correspondence to: H. Saito (hiros@cc.tuat.ac.jp) Published by Copernicus Publications on behalf of the European Geosciences Union.
|
2022-08-28T11:14:12.280Z
|
143,563,403 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1215/15314200-2009-034",
"MAG": "1996890591",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ten years ago in The Rise and Fall of English, I argued that the fall of English studies might be fortunate if the field could be reconstituted as a discipline. That no longer seems possible to me. In this article, I therefore argue for a shift from a field organized around the concept of literature to one organized around textuality: the production and reception of texts in all the media that use the English language. This will only be possible if we first recognize that English studies has really fallen.
|
2022-09-04T02:13:38.458Z
|
218,926,056 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2020/4987547",
"MAG": "3023658248",
"PubMedCentral": "8654564"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://downloads.hindawi.com/journals/bmri/2020/4987547.pdf"
}
|
Introduction Approximately 15 to 33% of all dialysis treatments are complicated by intradialytic hypotension (IDH). In this study, we tested the hypothesis that the intravenous administration of hydrocortisone prior to HD treatment could prevent IDH or at least decrease the drop in the blood pressure resulting from IDH. Methods This study was approved by our local ethics committee/IRB (2017/87) and by the Jordan Food and Drug Administration (7/clinical/18). Additionally, it is registered on ClinicalTrials.gov (NCT03465007). In this preliminary investigational study, we screened all chronic hemodialysis patients at our clinic who were 18 years of age or older (n = 82) for IDH. There were 14 patients included in the interventional part of this study; patients were given IV hydrocortisone for 3 consecutive HD sessions, followed or preceded by 3 intervention-free sessions where they were given 5 ml of saline as a placebo. Results The initial total sample size was 82 patients. The frequency of IDH at our clinic was 24.4%. Fourteen out of the 20 patients who were diagnosed with IDH agreed to enroll in the interventional part of our study. The mean age of the patients in the interventional part of our study was 53.5 years (±10.3). These patients included 5 (35.7%) men and 9 (64.3%) women. Upon comparing the number of hypotensive attacks with and without the hydrocortisone administration, we found a significant difference (p = 0.003) between the hydrocortisone and placebo treatments in which 12 (85.7%) patients had fewer IDH episodes with the hydrocortisone treatment than with placebo. Conclusion This preliminary investigational study found that the administration of a stress dose of hydrocortisone prior to hemodialysis could be an effective measure for preventing or minimizing the risk of IDH episodes. Additional prospective studies on this subject are needed. Ruling out adrenal insufficiency in patients diagnosed with IDH is also crucial.
|
2022-09-12T00:36:19.006Z
|
13,304,006 |
{
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"ArXiv": null,
"DOI": "10.1097/IJG.0000000000000500",
"MAG": "2569259874",
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"license": null,
"status": null,
"url": null
}
|
Purpose: &bgr;-adrenergic receptor antagonists (&bgr;-blockers) used in the treatment of glaucoma are an often-overlooked source of systemic adverse events. Ophthalmic timolol has been associated with severe systemic adverse events including numerous cases resulting in death. In recent years the number of fixed-dose combination therapies for glaucoma has grown rapidly, and among available combination therapies only the nonselective &bgr;-blocker timolol is used as the &bgr;-blocker component. Methods: A population-based study was conducted in Ontario, Canada between January 1, 2001 and December 31, 2012 to assess the shift to combination therapies in the management of glaucoma, and to investigate the impact of this shift on the relative use of selective and nonselective &bgr;-blockers in patients with this disease. Results: Between 2001 and 2012 timolol (nonselective &bgr;-blocker) use grew at an average annual rate of 2.2% (P<0.0001), whereas betaxolol (selective &bgr;-blocker) use declined by 14.1% per year (P<0.0001). These changes in the relative use of betaxolol and timolol coincided with changes in the relative use of combination and single-drug therapies. Over the study period, the use of &bgr;-blockers as single-drug therapy decreased by 7.7% annually (P<0.0001). In contrast, the use of combination therapies containing a &bgr;-blocker increased by 7.6% annually (P<0.0001). Conclusions: The introduction of fixed combination glaucoma therapies has been associated with a significant shift to greater use of nonselective &bgr;-blockers. In vulnerable older populations, this may have an important impact on patient safety that warrants further study.
|
2022-10-24T05:48:59.259Z
|
210,932,833 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.4103/IJDS.IJDS_90_19",
"MAG": "3003249674",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objectives: The aim of the study was to comparatively evaluate the efficacy of clinical and radiographic effects of calcarea phosphorica (CP) and calcium (Ca)(OH)2(Dycal) in indirect pulp capping of permanent teeth over a period of 6 months. Methodology: Permanent teeth were selected from children between the age group of 7 and 12 years, of which 20 teeth were considered, each for indirect pulp capping with CP and Ca(OH)2, respectively. Increase in dentin thickness was measured at baseline, 3 month, and 6 month on digitized radiographs using CorelDraw software. Results: Independent t-test had indicated that at the end of 3 and 6 months, a statically significant increase in dentin thickness with both CP and Dycal (P ≤ 0.001) was found within the CP group; the thickness of dentin formed was 0.089 mm ± 0.031 mm at first 3 months and 0.055 ± 0.022 mm at the second 3 months (P ≤ 0.001) evaluated using paired t-test. In the Dycal group, increment in dentin deposited was 0.068 mm at the first 3 months and second 3 months. It was 0.030 mm (P ≤ 0.001). Conclusion: Both clinically and radio graphically, CP is superior to Dycal as indirect pulp capping medicament in permanent teeth.
|
2022-12-18T06:37:41.103Z
|
248,831,741 |
{
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"ArXiv": null,
"DOI": "10.1128/spectrum.02158-21",
"MAG": null,
"PubMedCentral": "9241755"
},
"license": "CCBY",
"status": "GREEN",
"url": "https://eprints.qut.edu.au/236762/1/118429181.pdf"
}
|
Multidrug resistant Klebsiella pneumoniae are agents of life-threatening infections in animals and humans, with several multidrug resistant clones causing outbreaks of disease worldwide. It is generally accepted that only one clone will be dominant in an infection episode. ABSTRACT The global epidemiology of multidrug resistant Klebsiella pneumoniae, a serious threat to both animal and human health, is dominated by the spread of pathogenic clones, each separately evolving via acquisition of transferable antibiotic resistance or niche-specific virulence determinants. In horses, K. pneumoniae infection can lead to severe respiratory illness. Here, we characterized multiple isolates recovered from bronchial aspirates of a mare with pneumonia refractory to antibiotics. First, we used a combination of standard microbiology, bacteriophage cross-susceptibility and antibiotic resistance testing to profile the infecting K. pneumoniae population. The genomes of isolates with distinct fingerprints (pulsed-field gel electrophoresis) and unique combined bacteriophage/antibiotic profiles were then further analyzed using whole-genome sequencing. Adhesion to human epithelial cells and biofilm production were also measured as virulence indicators. Although it is commonly expected for one clone to dominate an infection episode, we identified five coexisting multidrug resistant K. pneumoniae sharing the same niche. One was a novel sequence type (ST4656), while the other four were all members of emerging human pathogenic clonal groups (ST307, ST628, ST893 and ST392). These isolates did not display significant differences from one another in terms of virulence or resistance and differed only in plasmid content from isolates implicated in severe human infections, with equal potential to prolong duration and severity of infection when sharing the same niche. This study highlights the importance of more precise surveillance and detection measures to uncover bacterial heterogeneity, reminding us that the “single clone” concept is not an absolute in invasive bacterial infections. IMPORTANCE Multidrug resistant Klebsiella pneumoniae are agents of life-threatening infections in animals and humans, with several multidrug resistant clones causing outbreaks of disease worldwide. It is generally accepted that only one clone will be dominant in an infection episode. In this study, we investigated K. pneumoniae isolates from a horse with severe pneumonia and demonstrated co-occurrence of multiple sequence types previously identified as emerging human pathogens. The equine isolates are not significantly different from one another in terms of virulence or resistance, with equal potential to prolong duration and severity of infection, and are indistinguishable from isolates recovered from humans, except for plasmid content. Our study highlights how the “one dominant clone” concept is not an absolute in severe infection, illustrating the need for improved diagnostics to track heterogeneity of infection, and reinforces the importance of cross-monitoring of environmental and human reservoirs of multidrug resistant pathogens.
|
2022-12-23T02:28:44.943Z
|
43,054,217 |
{
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"ArXiv": null,
"DOI": "10.1159/000447115",
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"license": null,
"status": null,
"url": null
}
|
Background/Aims: Early initiation of renal replacement therapy (RRT) is recommended in order to improve the clinical outcome of patients who develop an acute kidney injury (AKI). However, markers that guide an early RRT initiation do not really exist currently. Methods: Urine and serum samples were prospectively collected from 120 AKI patients. Depending on the necessity of initiating RRT, patients were divided into 2 different groups: dialysis (n = 52) and non-dialysis (n = 68). Results: Comparative urinary proteomic analyses identified 4 different proteins (fatty acid binding proteins 1 and 3 (FABP1 and FABP3), β-2-microglobulin (B2M), cystatin-M (CST6)) that discriminate AKI patients with high risk for RRT. Western blot analysis confirmed the proteomics data for FABP1 and FABP3 but not for B2M and CST6. Validation analysis confirmed that the FABP1 and FABP3 fulfilled the requirement of functioning as markers for AKI patients with risk to dialysis (p < 0.001). Conclusion: The release of high amounts of FABP1 and FABP3 in urine of AKI patients could serve as a diagnostic/prognosis marker for RRT initiation in these patients.
|
2022-12-17T06:46:44.950Z
|
126,562,638 |
{
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"ArXiv": null,
"DOI": "10.4324/9780203463086",
"MAG": "627757569",
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"license": null,
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|
1. Ageing in the Asia-Pacific region: issues, policies and contexts David R. Phillips 2. Demographic dimensions of ageing in East and Southeast Asia Kevin Kinsella 3. Research and development in ageing in the region Gary Andrews and Albert I Hermalin 4. Long-term care issues in Asia Pacific region Edward Leung 5. Financing health and long-term care for ageing populations in Asia Pacific Phua Kai-Hong 6. Ageing in Japan: retirement, daily lives, pensions and social security Daisaku Maeda and Hisanori Ishikawa 7. Development of Long-Term Care for elderly people in Japan Hisanobu Ishikawa and Daisaku Maeda 8. Ageing in Hong Kong Nelson Chow 9. Singapore's ageing population: social challenges and responses S. Vasoo, Tee-Liang Ngiam and Paul Cheung 10. Population ageing in China Du Peng and Guo Zhi-gang 11. Ageing and aged care in Taiwan Helen Bartlett and Shwu-chong Wu 12. Ageing in Korea: issues and policies Sung-jae Choi 13. Ageing in Thailand: an overview of formal and informal support John Knodel, Napaporn Chayovan, Chutima Suraratdecha and Siriwan Graisurapong 14. Ageing in Malaysia: issues and policies Tan Phoo Chang and Miss Ng Sor Tho 15. Ageing in the Philippines: an overview Joy Natividad 16. Lansia: elderly people in Indonesia at the turn of the century Graeme Hugo 17. Ageing, Islam and care for older persons in Brunei Darussalam Mark Cleary and Hairuni Ali Maricar 18. Older people in Vietnam amidst transformations in social welfare policy John Knodel, Bui The Chong, Truong Si Anh, Daniel Goodkind and Jed Friedman 19. Ageing in Cambodia: tradition, change and challenges Elisabeth Uphoff
|
2022-12-29T14:34:43.768Z
|
112,926,487 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.4307/jsee.44.3_55",
"MAG": "2329649744",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.jstage.jst.go.jp/article/jsee1995/44/3/44_3_55/_pdf"
}
|
The industrial world is now striving toward the establishment of a global marketplace with worldwide competition. Therefore, companies must ensure that their efforts are focused on this internationalization, and must aim to increase their competitiveness.Considering this new international focus, the industrial world needs individuals who are able to demonstrate the following talents and abilities:a)The ability to speak and understand different languages.International communication and the globalization of business is related not only to economic exchange but also to cultural exchange.b) Problem-finding and solving abilities and creativity.These skills are necessary so that new technology can be developed and applied both domestically and internationally.c) Initiative and the ability to think and take action.Individuals must be able to embrace challenge by thinkng for the-mselves and taking initiative, as opposed to simply following orders.In the ways mentioned above, human resources are currently underde-veloped within the industrial world. Also important is the creation of an open information exchange between the administrative, academic, and in-dustrial worlds. Such an exchange is necessary for "the promotion of basic research and the education of scientific technology" for our technology-oriented country, and for the entire industrial world.
|
2022-02-10T02:51:42.679Z
|
222,535,761 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.1674-845X.2013.07.004",
"MAG": "3030574810",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective To investigate changes in tear dynamics and corneal sub-basal nerve fiber regeneration after laser in situ keratomileusis (LASIK) surgery with a femtosecond laser and a mechanical microkeratome.Methods In a prospective case-control study,40 eyes of 20 patients were treated with FEMTO LDV femtosecond laser LASIK surgery (F-LASIK group) or mechanical microkeratome LASIK surgery (M-LASIK group) respectively.Tear film break-up time (BUT),Schirmer I test with corneal fluorescein staining (FS) and in vivo confocal microscopy of corneal subbasal nerve fibers (CSNFs) were obtained preoperatively and 1 and 3 months after surgery.Images of the CSNFs were analyzed to evaluate nerve regeneration.Data were analyzed using repeated measures ANOVA,an independent samples t test,Mann-Whitney U test and Spearman correlation analysis.Results At 1 and 3 months after operation the average of BUT of F-LASIK group was significantly longer than that of M-LASIK group (t=-2.195,-2.174,P<0.05).Schirmer I test results and the FS were comparable between the 2 groups.The nerve regeneration score was a little higher in F-LASIK group (1.03±0.63) than that in M-LASIK group (0.83±0.55) at 1 month after surgery,but there was no significant difference (Z=-1.400,P>0.05).The nerve regeneration score in F-LASIK group (2.31±0.83) was significantly higher than that in M-LASIK group (1.93±0.80) at 3 months after surgery (Z=-2.100,P<0.05).Significant positive correlations were found between Schirmer I test and the CSNFs regeneration score (r=0.231,P<0.01),while there was no statistically significant associations between the CSNFs regeneration score and BUT (r=0.143,P>0.05) or FS (r=-0.049,P>0.05).Conclusion The recovery of tear dynamics and corneal subbasal nerve fibers is faster in FEMTO LDV LASIK than in traditional LASIK.Schirmer I test is increase with the CSNFs regeneration.
Key words:
Femtosecond laser; Keratomileusis,laser in situ; Tears; Nerve regeneration
|
2022-01-27T01:54:36.195Z
|
247,641,367 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12968/chhe.2022.3.1.46",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
While it is still unclear how many young people have suffered mental health problems as a result of the pandemic, data from previous disasters suggests that many will have been affected in some way, with some also suffering post-traumatic stress disorder as a result.
|
2022-09-04T15:33:20.383Z
|
21,525,055 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1042/CS0650491",
"MAG": "2404527503",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The influence on leucine disposal of physiological alterations in plasma insulin concentrations was examined in three groups of healthy male subjects, six in each group. After an overnight fast the subjects received an intravenous infusion of either leucine (300 mumol/min for 150 min, series A), or leucine plus glucose (2.2 mmol/min, series B), or leucine, somatostatin (7 micrograms/min) and glucagon (1 ng/min, series C). Arterial concentrations of substrates and their net exchange across the splanchnic and leg tissues were determined with a catheter technique. Insulin concentrations rose from 12 +/- 2 to 20-22 mu-units/ml in series A, from 11 +/- 3 to 60-65 65 mu-units/ml in series B and decreased from 8 +/- 1 to approximately 5 mu-units/ml in series C. The basal leucine concentration for all subjects was 109 +/- 8 mumol/l and it rose progressively during the infusions. In series A, the level was 598 +/- 20 mumol/l after 150 min. The corresponding value was 542 +/- 38 mumol/l in series B and 651 +/- 25 mumol/l in series C. Significant differences were observed between series A and B (P less than 0.05) and series A and C (P less than 0.01) when data for 90-150 min of infusion were combined (analysis of variance). In all groups the leucine infusion resulted in an augmented net uptake of leucine across the leg (77-85 mumol/min) and across the splanchnic bed (61-72 mumol/min) but no significant intergroup differences were observed.(ABSTRACT TRUNCATED AT 250 WORDS)
|
2022-09-06T03:51:08.423Z
|
206,120,344 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/c8cc00183a",
"MAG": "2785273347",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
1,1-Disubstituted indazolium hexafluorophosphates were synthesized via intramolecular electrophilic amination reactions under mild conditions. The crystal structures were determined and are consistent with the presence of a stable N-N bond, which can be cleaved by hydrogenation. Both experimental and computational studies suggest a covalent bonding character of the N-N bond, with diminished aromaticity of the newly formed pyrazolium ring due to the quaternary ammonium atom (N1), in contrast to the aromatic character of the parent indazole.
|
2022-09-28T06:39:24.814Z
|
139,618,609 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.3390/MET8121000",
"MAG": "2902286386",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The paper investigated the residual strain and stress distribution, microstructure, and macro-texture along the transverse direction of commercially pure titanium grade 2 samples prepared by the CONFORM ECAP technique. This method belongs to the severe plastic deformation methods; hence, it could be assumed that residual stress fields would be present in the work-pieces. Residual stresses cannot be directly measured; thus, neutron diffraction measurements, Electron back-scatter diffraction (EBSD) investigations, and local X-ray macro-texture measurements were performed in different regions of the sample to determine the data for the residual stress calculation. The calculation was based on the modified Kröner model. Neutron diffraction strain scans and residual stress calculations revealed that symmetrical residual strain and stress gradients with compression character were present in the axial and hoop direction after one and two passes. Asymmetric distribution of the residual strains and stresses remained after the third pass of the CONFORM ECAP. EBSD investigations showed that after the first pass, significant grain refinement occurred; however, further passes did not cause any dramatic grain refinement. X-ray texture measurements revealed that local macro-texture was dependent on the number of passes of the CONFORM ECAP and on the investigated area in the samples.
|
2022-11-25T19:57:06.007Z
|
219,062,528 |
{
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"ArXiv": null,
"DOI": "10.15369/sujms.32.1",
"MAG": "3021645584",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://www.jstage.jst.go.jp/article/sujms/32/1/32_1/_pdf"
}
|
: High-intensity focused ultrasound ( HIFU ) can non-invasively irradiate inside the body. However, when used to treat fetuses, it can cause thermal burns of the mother ʼ s abdominal wall at the skin interface. This study was carried out to determine whether a modified HIFU transducer enabling split-aperture irradiation can prevent thermal burns. Two HIFU transducers were compared: a conventional transducer using full-aperture irradiation and a modified transducer using split-aperture irradiation. The modified transducer was divided into six sectors for split-aperture irradiation and had a larger surface area and a smaller F number ( focal length / aperture diameter ) than the conventional transducer. HIFU was delivered to eight sites on the left and right leg of a three-month-old baby pig under general anesthesia, and the sites were assessed for thermal burning by two or more derma-tologists. The same person performed all irradiations. Full-aperture irradiation with the conventional transducer caused deep dermal burns at all target sites, while split-aperture irradiation with the modified transducer caused only epidermal burns or superficial dermal burns. Split-aperture irradiation using a modified HIFU transducer with six sectors and a smaller F number reduces the severity of skin burns, and thus will improve the safety of HIFU therapy.
|
2022-12-18T02:38:30.846Z
|
25,706,855 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1345/aph.1E484",
"MAG": "2161206754",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND: Linezolid is an oxazolidinone antimicrobial with excellent oral bioavailability and tissue penetration and is active against multidrug-resistant skin/soft tissue pathogens. OBJECTIVE: To study the pharmacokinetics and antibacterial activity of linezolid against selective skin/soft tissue pathogens in obese patients. METHODS: We obtained multiple serum samples from 7 obese patients (>50% over their calculated ideal body weight) receiving oral linezolid 600 mg every 12 hours for treatment of cellulitis. Following a minimum of 3 doses, serum concentrations of linezolid were measured in each subject prior to (trough) and 1 and 6 hours after a dose. These samples were then tested against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) (linezolid minimum inhibitory concentrations [MICs] 1.0, 2.0, 4.0 μg/mL) and one strain each of vancomycin-resistant Enterococcus faecium (VRE) (MIC 2.0 μg/mL), Bacteroides fragilis (MIC 2.0 μg/mL), and Peptostreptococcus magnus (MIC 1.0 μg/mL). Serum inhibitory titers (SITs) and bactericidal titers (SBTs) were measured at each time point, and the median activity for these 7 patients was calculated. RESULTS: Mean linezolid serum concentrations were 4.2, 12.3, and 7.2 μg/mL at these respective time points. Median SITs for 12 hours (100% of the dosing interval) were observed against each organism with the exception of the least susceptible strain of MRSA (MIC 4.0 μg/mL); serum inhibitory activity was observed only at the one-hour time point against this isolate. Furthermore, prolonged (⩾6 h) median SBTs were observed against one isolate of MRSA (MIC 1.0 μg/mL) as well as the strain of VRE and P. magnus. CONCLUSIONS: Serum concentrations of oral linezolid in this patient population were diminished compared with those of healthy volunteers, but still provided prolonged serum inhibitory activity against common pathogens associated with skin/soft tissue infections. One treatment concern would be an obese patient receiving oral linezolid who was infected with a less susceptible (MIC ⩾4.0 μg/mL) strain of S. aureus. Bactericidal activity was also observed against selective pathogens.
|
2022-12-22T15:32:10.875Z
|
177,948,355 |
{
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"ArXiv": null,
"DOI": "10.17289/jkscs.29.2.201506.115",
"MAG": "1838698806",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://doi.org/10.17289/jkscs.29.2.201506.115"
}
|
급속한 산업화에 따라 공업단지의 면적이 넓어지고 있으며, 이에 따라 공단이 포함된 지역 경관에 큰 변화가 나타나고 있다. 이러한 무분별한 공업단지의 확산은 주변 경관과의 조화를 무너뜨리는 등의 부정적인 영향도 적지 않으며, 지역 경관을 고려한 색채 계획을 통해 전반적인 이미지 개선이 지속적으로 요구된다. 그중에서도 공장 지붕 색채의 경우, 건축물의 가장 넓은 면적을 차지하고 있는 만큼 지역 경관과의 연속성을 고려한 색채 계획이 반드시 필요하다. 따라서 본 연구에서는 공장단지의 지붕 색채 측색 조사를 통하여 문제점을 도출하고, 지역 환경 색채의 적용하여 개선된 디자인의 선호도 조사를 실시하여 공장 지붕 색채 개선에 대한 근거를 마련하고자 한다. 연구 결과는 다음과 같다. 조사지역 사진의 원본(사진A)과 본 연구에서 제안하는 개선안(사진B)을 비교하여 개인적 선호도, 주변 경관과의 조화도, 주변 경관과의 연속성, 지역 환경과의 어울림, 색채의 기능성, 색채 만족도를 조사한 결과, 모든 항목에서 개선안으로 제시된 사진B에 대해 비교적 긍정적인 응답이 나타났다. 그러나 두 사진을 동시에 보여주며 비교하였던 앞의 설문조사와 달리, 각 사진을 개별적으로 보여주며 실시한, SD법 분석에서는 사진B에 대한 이미지가 부정적으로 나타났다. 본 연구가 주변 경관과의 조화성과 연속성, 개성이 높은 공업단지 지붕 색채 개선에 기여하기를 기대한다.
|
2022-01-24T18:53:34.580Z
|
233,835,149 |
{
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"ArXiv": null,
"DOI": "10.1161/STR.52.SUPPL_1.P369",
"MAG": "3138630532",
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"license": null,
"status": null,
"url": null
}
|
Introduction: White matter hyperintensities (WMH) are a radiographic marker for cerebral small vessel disease (CSVD). Conditions altering cerebral venous outflow such as elevated central venous pre...
|
2022-02-07T21:44:10.786Z
|
196,881,593 |
{
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"ArXiv": null,
"DOI": "10.1002/CHIN.201144155",
"MAG": "2949322835",
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"status": null,
"url": null
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|
Highly efficient and regioselective methods for the synthesis of 1,5- and 1,8-naphthyridines (II), (V) catalyzed by I2 and InCl3, resp., are developed.
|
2022-02-08T06:53:02.938Z
|
144,007,811 |
{
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"ArXiv": null,
"DOI": "10.1080/00336297.2007.10483548",
"MAG": "2016963687",
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},
"license": null,
"status": null,
"url": null
}
|
The world is full of suffering. How then can we justify spending time at play? Given certain utilitarian assumptions, it becomes clear that time spent playing could be put to better use. Furthermore, if a life could have been saved by working instead of playing a “round of golf,” then our passion for play and games is not only a matter of morality, but likewise a matter of life and death. In this article I argue that such thinking is confused; primarily about how we develop a healthy concern for other people. Using the idea of “mediating institutions,” play and games are defended on the grounds that human particularity necessitates learning compassion—needed to reduce suffering—through the kind of intimate human relationships found at play.
|
2022-12-20T10:24:52.387Z
|
18,277,289 |
{
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"ArXiv": null,
"DOI": "10.1109/INES.2010.5483855",
"MAG": "2046437317",
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"status": null,
"url": null
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|
This paper presents a multiagent system that can process stereoscopic images and detect people with a stereo camera. In the first of two phases, the system creates a model of the environment using a disparity map. It can be constructed in real time, even if there are moving objects present in the area (such as people passing by). In the second phase, the system is able to detect people by combining a series of novel techniques. A multi-agent system (MAS) is used to deal with the problem. The system is based on cooperative and distributed mechanisms and was tested under different conditions and environments.
|
2022-12-23T02:01:01.381Z
|
226,751,761 |
{
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"ArXiv": null,
"DOI": "10.1051/e3sconf/202019706004",
"MAG": "3093542927",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/57/e3sconf_ati2020_06004.pdf"
}
|
Nowadays the climate change caused by the green-house effect increasing is a world-wide issue with which scientists have to face. Being the passenger vehicles filled with fossil fuels, the emission of the carbon dioxide green-house gas is unavoidable. In order to slowdown both the global warming and the fossil fuels wasting, lower fuel consumptions, thus high efficiency engines, are required. Currently, the coupled use of downsizing and direct injection in spark ignited engines meets both high efficiency and power-demand requirements. Being downsized engines more compact, the distance between the injector and the engine walls are shorter. Thus, depending on the engine operating condition, the fuel spray wall impingement may occur leading to the formation of a liquid fuel film. If the wall impingement occurs against the cylinder liner wall, which is wetted by a thin oil layer, the motor oil and the landed fuel dilute until the piston arrival. At this time, the mass transport by diffusion have promoted the creation of an oil-fuel mixture. Thus, while thicker part of the mixture layer is scraped into the piston top land crevice, the thinner, whose properties are degraded by the fuel contamination, remains on the cylinder liner. The mixture accumulated inside the crevice may be scattered due to the piston inertia leading to the oil detachment and transport in the combustion chamber. The latter may cause both abnormal combustions named preignitions at high loads and increased particulate emissions at low loads, cold states, and cat-heating. This paper reports the implementation of a onedimensional numerical model for the dilution between fuel and motor oil in a stroke of a gasoline engine. The model aims to give the composition of the oil-fuel mixture both on the cylinder liner after the piston arrival and in the piston top land crevice.
|
2022-09-07T08:25:13.914Z
|
194,611,250 |
{
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"DOI": "10.4000/studifrancesi.7530",
"MAG": "2934980228",
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},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://journals.openedition.org/studifrancesi/pdf/7530"
}
|
La presente edizione – col commento e saggio che l’accompagna – e un interessante contributo alla storia della Rezeption della cultura italiana nella Francia del Cinquecento. Per secoli i Tre libri della Humanita di Christo sono stati considerati opera di pura strategia politica da parte di un Aretino che mirava ad ottenere il cappello cardinalizio. Solo negli ultimi decenni questa posizione critica e stata ridimensionata e i Tre libri sono stati inseriti nel quadro delle contrastanti filiere...
|
2022-01-27T16:55:31.238Z
|
237,971,754 |
{
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"DOI": "10.1079/9781789245431.0024",
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"url": null
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|
Abstract
This chapter discusses current progress and prospects of molecular breeding and strategies for developing better saline-tolerant sorghum (Sorghum bicolor) varieties. Most molecular breeding techniques for salt tolerance have been carried out in controlled environments where the plants were not exposed to any variation of the surrounding environment, producing reliable results. Due to the polygenic nature of salt tolerance, the identified quantitative trait loci (QTLs) could be false QTLs. Therefore, QTL validation is important in different plant populations and field conditions. Subsequently, marker validation is important before utilizing marker-assisted selection for screening salt-tolerant plants. Combining molecular breeding with conventional breeding can hasten the development of salt-tolerant sorghum varieties.
|
2022-01-27T18:40:22.821Z
|
220,488,907 |
{
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"DOI": "10.1177/004056399205300311",
"MAG": "2319394154",
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"license": null,
"status": null,
"url": null
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|
cally evaluates the options. In the section "History of Interpretation," M. traces the emergence of early Christian allegorization from the early Jewish, and demonstrates that even as early as Origen the interpretation of Songs was a reflection of contemporary anthropological understandings. This remains true even in present-day discussions where the anthropological concerns focus on the sexual, and therefore the more literal sense of the text. M. notes that this approach to the text, at least as a broad agreement of scholars from whatever confessional background, is a recent phenomenon. Even among Catholics, who have long resisted this trend and have preferred to talk about the Song's "parabolic character, prophetic spirit and anthological style, the tide has also turned... toward a fuller appreciation of the Song's literal sense." Because of the renewed emphasis on recovering the literal sense of the text, M. examines the various ancient bodies of literature— Egyptian, Sumero-Babylonian and Canaanite—which have been adduced as possible thematic and literary influences on Songs. He finds that although many have looked to Egyptian sources for the most promising parallels, actually little if any direct influence can be detected. Sumerian love poetry, on the other hand, has striking similarities, especially in the dialogic structure it frequently employs, and even more in its figures of speech, its use of sexual euphemisms, and its obvious delight in double-entendre devices. M.'s translation manages to preserve many of these features, a task that has bedeviled many of his predecessors. Pope's translations, e.g., in an effort to preserve the hard-to-translate erotic elements in the double meanings, frequently are more clever than poetic. M. preserves the lushness without destroying the poetic subtlety. Where an appropriate turn of the English seems impossible to find, M.'s notes on the text, conveniently placed on the pages facing the translation, clearly explain the connotations and ambiguities of the Hebrew text. The splendid layout of the book, a characteristic of the Hermeneia series, enables M. to make full use of his forty years of research on this biblical text without drowning the reader in it. The meat of the text occupies the upper register of each page of introduction and commentary, with all excursuses and technical data relegated to the bottom half—easily accessible, without hopelessly complicating the primary text as often happens in the Anchor Bible.
|
2022-02-08T01:23:35.539Z
|
187,694,773 |
{
"externalids": {
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"DOI": "10.25143/amhr.2010.IX.03",
"MAG": "2755288142",
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"status": null,
"url": null
}
|
Latviešu medicīnas attīstībā rakstītam vārdam vēsturiski ir ļoti liela nozīme. Pirmkārt, tas ir tālab, lai saglabātu pilnvērtīgu un labskanīgu profesionālo medicīnas valodu ar latviešu terminiem un internacionālu, uz pierādījumiem balstītu medicīnisku domāšanu. Otrkārt, dzimtajā valodā cilvēkam jebkuru mācību vielu ir vienkāršāk apgūt, bet latviešiem laikmetu griežos vairākkārt nācies mainīt prioritāro svešvalodu atkarībā no politiskās konjunktūras – prioritāra bijusi vācu, krievu vai angļu valoda, bet cilvēkiem gados, kā zināms, jaunu valodu profesionālā līmenī apgūt nav viegli. Tālab latviešu valodai medicīnas apmācībā un mūžizglītībā īpaša nozīme bija 20. gs. 50. un 90. gados, kad ienāca literatūra citā svešvalodā. Treškārt, nacionālas medicīnas grāmatas ir nozīmīgs nācijas izdzīvošanas un attīstības rādītājs, gluži kā nacionālā mūzika vai nacionālais teātris.
|
2022-02-08T10:36:30.918Z
|
25,608,589 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICSENS.2008.4716720",
"MAG": "2144695412",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this contribution we present a novel disposable micro fluidic biosensor array for parallelized monitoring of cell adhesion during pathogenic infection. The biosensor array consists of 4 bioreactor chips and a flow distribution network. Thus, 4 biological experiments, can be run in parallel. Each bioreactor chip contains 4 quartz crystal resonators (QCRs) with randomly spread cells on top which are stimulated identically. Insofar, the array enables the analysis of the cellular response dependent on cell distribution. Injection molding technology was applied for the fabrication of low cost and disposable micro fluidic devices. Sensor signals are monitored with a miniaturized impedance analyzer combined with a novel sensor interface electronics for 16 QCRs. Light microscope pictures can be acquired in parallel. The array was used for the analysis of Madin-Darby canine kidney cells (MDCK-II). Results show significant variations in sensor signals, respectively cellular response, that can be attributed to different cell distributions on the sensor surface.
|
2022-02-12T18:09:11.924Z
|
13,837,751 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SAMI.2015.7061853",
"MAG": "1969548975",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper deals about sensor network and its communication and energy consumption reduction. Our implementation is focused on reaching communication reduction to spare power resources on sensor nodes. To decrease amount of communication and not decrease amount information about monitored or controlled system we used data mining technique and events based communication. Data mining technique was implemented directly on sensor node, which offers enough storage and computing sources. Implemented data mining technique is SPRT (Sequential Probability Ratio Test). Using this method, the sensor decides, if the monitored system is behaving abruptly. Like the result of decision, the sensor creates appropriate type of event. The sensors are subscribed to event listener, which handle these events. Using events in sensor network, with transmitting only valuable information, has good result in communication reduction and faster feedback from monitored system and with information.
|
2022-02-13T03:12:59.898Z
|
247,495,526 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/2058-8585/ac5e0e",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Inkjet-printed silver conductive patterns are used in many flexible electronics applications ranging from health care, inventory management to aviation. Understanding of the electrical behavior of these printed patterns under different mechanical stresses and environment conditions is important for their real-life application use. The present work addresses a special system, silver interconnects on silica-coated porous polyethylene terephthalate (PET) substrate. The combination of the porosity, roughness, and a sintering temperature limited by the low glass transition temperature (Tg) of the PET leads to unique behaviors that may easily be misinterpreted. Thus, while the interconnect resistance does increase during stretching and decrease with unloading the resistance at zero load was lower after a given cycle than before it, and it continues to drop for quite a while in consecutive cycles. This effect was stronger for higher strain amplitudes, but it could be reduced or eliminated by preceding low temperature annealing. Humidity exposure and thermal cycling also led to major drops in resistance, albeit for different reasons, but both led to faster fatigue in subsequent mechanical deformation. Accounting for these behaviors in the assessment of life under realistic use conditions requires a mechanistic understanding.
|
2022-03-17T16:07:11.364Z
|
67,185,122 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3301500",
"MAG": "2930848346",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We present a new approach for efficient process synchronization in parallel discrete event simulation on multicore computers. We aim specifically at simulation of spatially extended stochastic system models where time intervals between successive inter-process events are highly variable and without lower bounds: This includes models governed by the mesoscopic Reaction-Diffusion Master Equation (RDME). A central part of our approach is a mechanism for optimism control, in which each process disseminates accurate information about timestamps of its future outgoing interprocess events to its neighbours. This information gives each process a precise basis for deciding when to pause local processing to reduce the risk of expensive rollbacks caused by future “delayed” incoming events. We apply our approach to a natural parallelization of the Next Subvolume Method (NSM) for simulating systems obeying RDME. Since this natural parallelization does not expose accurate timestamps of future interprocess events, we restructure it to expose such information, resulting in a simulation algorithm called Refined Parallel NSM (Refined PNSM). We have implemented Refined PNSM in a parallel simulator for spatial extended Markovian processes. On 32 cores, it achieves an efficiency ranging between 43--95% for large models, and on average 37% for small models, compared to an efficient sequential simulation without any code for parallelization. It is shown that the gain of restructuring the naive parallelization into Refined PNSM more than outweighs its overhead. We also show that our resulting simulator is superior in performance to existing simulators on multicores for comparable models.
|
2022-09-03T08:01:35.960Z
|
31,860,632 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1053/JPDN.2001.23157",
"MAG": "2003325781",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Parents who care for a child with a chronic illness are forced to relinquish much of the control of the child's care when the child is hospitalized. By using the family systems theory as the underlying framework, the amount of control that parents of children with chronic illness wanted over their hospitalized child's care, and the degree to which parents felt health care professionals valued their expertise, was examined in a national sample of 50 parent caregivers. Participation in information sharing and technical care were areas over which parents wanted the most control. Nurses and attending physicians were rated highest in valuing parental expertise. Content analysis of an open-ended question on parental control revealed that parents felt a higher quality care was given at home than in the hospital; nurses were too busy or understaffed to provide optimal care in the hospital; and the child's control of care and decision making should increase as the child grew older.
|
2022-12-18T08:59:59.350Z
|
76,382,496 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5035/NISHISEISAI.37.1225",
"MAG": "2317471062",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In order to know the causes of protrusio acetabuli and destruction of the femoral head in rheumatoid arthritis, the relationship between protrusio acetabuli, destruction of the femoral head and strength of bone were examined radiologically. Material consists of 24 hips in 14 cases, which were followed up for more than 6 months. Protrusio acetabuli had a tendency to occur in the cases which have high osteoblastic response in the femoral head and severe systemic osteoporosis. On the other hand, destruction of the femoral head was hardly observed among the cases which have normotrophic osteoblastic response in the femoral head and acetabulum, but it does not related to the osteoporosis. In conclusion, it was suggested that the development of changes of the hip joint in rheumatoid arthritis was related to the bone strength of the hip and systemic osteoporosis.
|
2022-02-11T06:29:38.954Z
|
233,282,959 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31876/er.v3i28.721",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "http://www.revistaespirales.com/index.php/es/article/download/721/639"
}
|
This is an empirical research studio, conclusive-quantitative approach of a transversal and non-experimental, based on a survey with three samples integrated by Micro and Small Enterprises (MSE) of Celaya (Guanajuato) in Mexico, of Piracicaba (São Paulo) in Brazil and of Bogota in Colombia. Each sample was for convenience of 14 companies for each country. The objective was identify the differences in the value of the Technology marketing knowledge to through the tacit and explicit transfer of knowledge and the conversion of knowledge for market competitiveness. It was found that the MSE of three countries, almost always share the same characteristics, the most outstanding from the empirical management and without sector expertise to be competitive from a marketing perspective, since the lack of of strategic plans or programs in this discipline, makes them disappear or have problems in their marketing and positioning processes.
|
2022-03-09T16:30:17.204Z
|
38,374,224 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/09638237.2011.556157",
"MAG": "2050842818",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
There is little evidence that systematic mental health promotion (MHP) policies exist in the countries of the European Union (EU). In order to explore this, a sample of public health stakeholders in ten European regions was selected. Each region was asked to complete a postal questionnaire about structural indicators of those environmental factors that might have an impact on mental health; stakeholders were also provided with information on MHP concepts and strategies. Subsequently the regions were visited, and stakeholders were interviewed on their MHP policies using an open-ended questionnaire. It was found that there were no existing procedures or plans that could support the hope that systematic MHP policies would be developed in the next years in the EU. Only three of the ten regions had started to develop such policies. An 8-item questionnaire on the framework and process of MHP policy development was developed and used in the present study. This questionnaire may be auseful instrument in future studies on structural indicators of mental health.
|
2022-05-24T21:21:10.802Z
|
2,800,651 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1527-5299.2007.06491.x",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The major components of the physical examination of patients with heart failure are presented to allow practical application by physicians and nurses working in this arena. Part II contains the key elements of the chest, precordial-cardiac, hepatic, and peripheral examination in this specific clinical setting. Supplemental maneuvers are provided. Finally, the overall role and merits of the physical examination in managing the heart failure patient are discussed.
|
2022-09-11T09:04:25.974Z
|
13,094,912 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/299996.300026",
"MAG": "1965466256",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://www.cs.york.ac.uk/rts/docs/SIGDA-Compendium-1994-2004/papers/1999/ispd99/pdffiles/2_0_2.pdf"
}
|
This paper describes a new procedure for generating very large realistic benchmark circuits which are especially suited for the performance evaluation of FPGA partitioning algorithms. These benchmark circuits can be generated quickly. The generation of a netlist of 1OOK CLBs (500K equivalent gates), for instance, takes only two minutes on a standard UNIX workstation. The analysis of a large number of netlists from real designs lead us to identify the following five different kinds of sub-blocks: Regular combinational logic, irregular combinational logic, combinational and sequential logic, memory blocks, and interconnections. Therefore, our generator integrates a sub-generator for each of these types of netlist. The comparison of the partitioning results of industrial netlists with those obtained from generated netlists of the same size shows that the generated netlists behave similarly to the originals in terms of average filling rate and average pin utilization.
|
2022-09-14T23:39:55.421Z
|
27,128,282 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1476-5381.1987.tb16818.x",
"MAG": "2054064981",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc1917286?pdf=render"
}
|
Guinea‐pig olfactory cortical neurones in vitro were voltage clamped by means of a single intracellular microelectrode technique. Hyperpolarizing voltage commands from holding potentials between −40 to − 50 mV produced slow inward current relaxations reflecting deactivation of the M‐current (IM). IM was reversibly suppressed by 30 μm muscarine or carbachol; this suppression was insensitive to pirenzepine (up to 300 nm) but was inhibited by gallamine (10–20 μm) or 4‐diphenyl‐acetoxy‐N‐methylpiperidine (100, 500 nm), suggesting the involvement of the M2‐type muscarinic receptor.
|
2022-12-10T09:45:53.476Z
|
125,573,165 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PhysRevD.28.1738",
"MAG": "2598080681",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We investigate a model for generating large masses for the scalar partners of the quarks and leptons for supersymmetric SU(5). The gauge group is extended to have sideways U(1) which breaks supersymmetry by the O'Raifeartaigh mechanism and generates scalar masses radiatively, while keeping the fermionic-mass corrections small. An explicit one-loop calculation of the scalar-mass corrections is carried out. For this SU(5)xU(1) model a light scalar partner of the leptons of either the second or the third generation is predicted by anomaly constraints.
|
2022-01-27T09:53:23.476Z
|
122,833,887 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TMTT.1974.1128442",
"MAG": "2155544054",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Required megawatt-level 30-MHz Iinewidth 496-mu m radiation for plasma diagnostics may be achieved in CH/sub 3/F using an oscillator-pulse-amplfier combination employing transverse optical pumping (TOP). It is estimated that an upper limit of 150 J of CO/sub 2/ laser pump energy is required to produce 1-MW (0.07-J 60-ns) far-infrared (FIR) pulses.
|
2022-02-09T18:55:18.656Z
|
118,729,801 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.34000",
"MAG": "1521922157",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The elastic scattering of proton from 3He and 4He is calculated with a microscopic momentum space optical potential. The theory is unique in its inclusion of the full structure of spin 1/2×1/2 scattering. It is equivalent to a co‐ordinate space potential with central, spin‐orbit and several tensor terms each described as non‐local, and velocity dependent. Also included are nucleon recoil and binding, antisymmetrized NN amplitudes, a Lorentz invariant angle tranformtion (no small angle approximation), and realistic form factors for the matter and spin distributions of nucleons within the nucleus.
|
2022-02-09T22:42:44.753Z
|
59,889,588 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3133/OFR92565",
"MAG": "163448424",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
YoNav is a real-time navigation and data acquisition program written in Microsoft C/C++ that provides navigation services on almost any DOS platform. The YoNav Graphical User Interface (GUI) supports virtually any VGA and most EGA graphics hardware. In its fullest configuration, YoNav will support up to 10 simultaneous serial RS232 channels, 4 channels of digital I/O, ttve video display and frame capture from 3 types of video input and graphic support for over 150 different printers. The same software will also operate on a notebook PC with only one or two serial inputs. YoNav is completely configurable by a small utility YoCfg that allows various pieces of optional hardware to be configured in or out of the system. Data can be logged in either or both a compact binary or standard USGS ascii format on any system disk. Post-plotting of binary format navigation data can occur while data is still being acquired through a multi-tasking time slice process. introduction During the winter of 1991, the USGS Marine Facility began development of a portable PC based integrated navigation system that would replace the aging navigation RhoRho ^system currently in use. One of the driving factors for a new navigation system was the completion of the GLORIA Exclusive Economic Zone (EEZ) work and the termination of the lease of the R/V Famella which had been the primary research vessel for marine operations since the late 1980's. The RhoRho system had been designed mainly to provide steering displays and navigation services to the GLORIA project on a ship that always had the same sensors, helmsmen and navigators. With the acquisition of a new vessel on the horizon, it became apparent that we needed a navigation system that could be portable, work with many different navigation sensors and have a modem graphical user interface that is both intuitive and easily learned by less experienced watchstanders. This paper describes and documents the operation and setup of this system known as YoNav. 2Gann, John T . 1988, Integrated GPS, Range-range and Hypeibolic Loran C Marine Navigation System for Use on IBM AT or Compatible Microcomputers, USGS Open File Report 88-562, 39 pages File Edit Utilities Display Config IYoNav V1.68 37 38.54393' N 122 12.75851' W (Scale 531 ) Figure 1. Anatomy of Main Navigation Display 255 15:54:22.686 37 36.45326' N 122 12.62669* W Trimbie NavTrakll
|
2022-02-11T15:59:32.433Z
|
17,719,614 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/WISA.2012.35",
"MAG": "2081337217",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Web services have been emerging and are by now one of the most popular techniques for building versatile distributed systems. With the increasing popularity of the Restful Web services on the network, how to select the real-world Restful Web services accurately from the ordinary web pages, thus increase the need for services discovering. In this paper, based on the researches of the SOAP-based Web services and Restful services, we develop a service pattern discovery system for the Restful Web services, and introduce the research on the service feature selecting and services classification.
|
2022-02-13T00:20:25.253Z
|
245,814,509 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5606/tftrd.2021.8555",
"MAG": null,
"PubMedCentral": "8790263"
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.5606/tftrd.2021.8555"
}
|
Objectives This study aims to evaluate the predictors of standard nerve conduction study (NCS) parameters in determining the presence of axonal loss by means of spontaneous activity in patients with mild and moderate carpal tunnel syndrome (CTS). Patients and methods Between May 2015 and April 2018, a total of 118 patients (11 males, 107 females; mean age: 52.3±10.6 years; range, 27 to 79 years) who underwent electrophysiological studies and were diagnosed with CTS were included. Demographic data of the patients including age, sex, and symptom duration were recorded. Electrodiagnostic studies were performed in all patients. All the needle electromyography (EMG) findings were recorded, but only the presence or absence of spontaneous EMG activities was used as the indicator of axonal injury. Results In 37 (31.4%) of the patients, spontaneous activity was detected at the thenar muscle needle EMG. No spontaneous activity was observed in any of 43 (36.4%) patients with normal distal motor latency (DML). There were significant differences in DMLs, compound muscle action potential (CMAP) amplitudes, sensory nerve action potentials amplitudes, and sensory nerve conduction velocities between the groups with and without spontaneous activity (p<0.05). The multiple logistic regression analysis revealed that DML was a significant independent risk variable in determining presence of spontaneous activity. The most optimal cut-off value for median DML was calculated as 4.9 ms. If the median DML was >4.9 ms, the relative risk of finding spontaneous activity on thenar muscle needle EMG was 13.5 (95% CI: 3.6-51.2). Conclusion Distal motor latency is the main parameter for predicting the presence of spontaneous activity in mild and moderate CTS patients with normal CMAP. Performing needle EMG of the thenar muscle in CTS patients with a DML of >4.9 ms may be beneficial to detect axonal degeneration in early stages.
|
2022-02-25T00:26:06.474Z
|
108,505,415 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMR.490-495.499",
"MAG": "1968371864",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents a novel MEMS high g acceleration sensor based on piezoresistive effect. For the designed sensor structure, the formula of stress, natural frequency and damping was derived in theory, and the resonant frequency can up to 500kHz. After the structure parameters were designed, the sensor was fabricated by the standard processing technology, and the sensitivity was tested by Hopkinson bar. According to the experimental results, the sensitivity of the high g acceleration sensor is 0.125μV/g at the impact load of 164,002g.
|
2022-02-10T07:00:22.720Z
|
246,750,432 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/MD.0000000000028733",
"MAG": null,
"PubMedCentral": "8830867"
},
"license": null,
"status": null,
"url": null
}
|
Abstract Background: Adolescent myopia has become a major public health problem in Asian countries and even the world. Due to its unstable prognosis and numerous complications, it has caused serious social and economic burden. As a common treatment in Asia, Chinese medicine has been shown to be effective in controlling the development of myopia, but its evidence-based medical evidence is not sufficient. Therefore, the purpose of this study is to evaluate the efficacy and safety of traditional Chinese medicine (TCM) in the treatment of adolescent myopia through network meta-analysis, and to provide evidence for clinical and scientific research. Methods: We searched seven databases for randomized controlled trials of TCM decoction for adolescent myopia, including PubMed, the Cochrane Library, EMbase, China National Knowledge Infrastructure, China Biological Medicine, Chinese Scientific Journals Database, and wan-fang databases, from the date of the establishment of each database to January 31, 2022. The network meta-analysis will be implemented through Aggregate Data Drug Information System 1.16.8 and Stata 13.0 software. Primary outcomes include distant vision, intraocular pressure, and diopter. Mean differences or odds ratios will be used for statistical analysis. We will ensure the reliability of the results through node-split model and heterogeneity analysis. In addition, the Cochrane Collaboration's tool and Grading of Recommendations Assessment, Development and Evaluation system will be used for the methodological quality and the evidence quality. Results: This study will provide reliable evidence for the clinical selection of TCM decoction in the treatment of adolescent myopia. Conclusion: The results of this study will evaluate the efficacy and safety of TCM decoction in the treatment of adolescent myopia, and provide decision-making references for future clinical and scientific research. Ethics and dissemination: This study did not require ethical approval. We will disseminate our findings by publishing results in a peer-reviewed journal. OSF registration number: DOI 10.17605/OSF.IO/VXQUP.
|
2022-04-02T17:59:38.887Z
|
133,926,336 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2113/GSCPGBULL.65.2.279",
"MAG": "2731820174",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract In Liard Basin of northern British Columbia, syn-depositional motion on the Bovie structure resulted in greater thicknesses of Cretaceous sediments. The Early Cretaceous Garbutt Formation was deposited during the initiation of a major marine transgression. Organic-rich shales and siltstones in its lower part record maximum flooding and have been informally termed the Radioactive Zone (RZ). The Garbutt Formation is dominated by shales and siltstones and is here subdivided into three informal units; the lower Garbutt Formation (LGF), the succeeding RZ and the upper Garbutt Formation (UGF). The combined thickness of the Radioactive Zone and lower Garbutt Formation is 40 to over 120 m thick and can be at greater than 2000 m depth in Liard Basin. The lower Garbutt Formation is not recognized east of the Bovie structure and the RZ is considerably thinner or absent locally, suggesting this area remained high relative to Liard Basin. Total organic carbon and Rock-Eval data suggest that the RZ is a good to very good source rock and that the LGF is also a good source rock. Organic matter is dominantly Type II kerogen, although more terrestrial Type III input becomes prevalent in western parts of the basin. Thermal maturity inferred from Tmax, in addition to hydrogen index levels, indicate that these rocks are in the oil window in northern Liard Basin and in the wet gas window within central Liard Basin. Porosities average 8% and matrix compositions average 39 wt.% quartz, 4 wt.% feldspar and calcite and 53 wt.% clays (illite/mica, kaolinite and chlorite). The properties of the RZ and LGF indicate that a potential liquids-rich shale gas play may occur within central Liard Basin.
|
2022-03-06T15:53:13.446Z
|
143,310,243 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/JCOM.12175",
"MAG": "1922346503",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We document how social contexts serve to refract media effects. We theorized the relationship between media use and individual-level knowledge (and attitude) would be stronger when community-level knowledge (and attitude) was low than when it was high. Data come from a national survey (N = 12,608 women and 1,237 men) conducted in Nepal. Knowledge and stigma toward people living with HIV were the 2 dependent variables. Hypotheses were tested 12 times: across the use of 3 media (newspaper, radio, television) × 2 study outcomes (knowledge and attitudes) × 2 genders. Predicted interactions were supported in 9 of the 12 tests. Findings point to the need to take into account the role of community factors in theorizing about media effects
|
2022-08-29T18:33:26.413Z
|
243,174,197 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/a-1498-1816",
"MAG": null,
"PubMedCentral": "9525142"
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1498-1816.pdf"
}
|
Zusammenfassung Hintergrund Mit dem Modellprojekt GERDA („Geschützter e-Rezept-Dienst der Apotheken“) wurde von der Landesapothekerkammer (LAK) und dem Landesapothekerverband (LAV) in Baden-Württemberg die Möglichkeit geschaffen, Rezepte im Rahmen von Online-Sprechstunden über das von der Kassenärztlichen Vereinigung Baden-Württemberg betriebene telemedizinische Portal „docdirekt“, zu verordnen. Vor diesem Hintergrund war das Ziel der Studie, Barrieren und fördernde Faktoren aufseiten der Apotheken für die Beteiligung an einer Versorgung, die eine elektronische Verordnung von Rezepten beinhaltet, zu explorieren und zu priorisieren. Auf Basis dieser Determinanten wurden Empfehlungen zur Optimierung einer erfolgreichen Implementierung ähnlicher Versorgungsangebote abgeleitet. Methode Es wurde ein Mixed-Methods-Design gewählt, um die Determinanten zu explorieren und zu priorisieren. Im ersten Schritt wurden Determinanten für die Beteiligung an einem System, welches die elektronische Verordnung von Rezepten ermöglicht mithilfe von Einzelinterviews mit an docdirekt beteiligten Teleärzten, niedergelassenen Hausärzten und Apothekern exploriert. Anschließend wurden diese Determinanten in einem zweiten Schritt durch eine quantitative Befragung von Apothekern priorisiert. Ergebnisse Von den 523 an der Umfrage teilgenommenen Apothekern war mehr als die Hälfte bereit sich an einem E-Rezept-System zu beteiligen, 8,5% schließen eine zukünftige Beteiligung aus. Insgesamt konnten 18 Determinanten für die Beteiligung an einem System, welches die elektronische Verordnung von Rezepten ermöglicht, exploriert werden. Der Schutz der freien Apothekenwahl wurde als wichtigster Aspekt für eine Beteiligung identifiziert. Gefolgt von der Möglichkeit einer Korrekturfunktion bei E-Rezepten (um z. B. Retaxierungen oder Medikationsfehlern zu vermeiden), der Integration des E-Rezepts in die bestehende Apotheken-EDV sowie dem gesetzlichen Ausschluss von direkten Verträgen mit Versandapotheken. Zeitersparnisse und eine ggf. höhere Vergütung wurden dagegen als weniger relevant bewertet. Schlussfolgerung Insgesamt gab über die Hälfte der befragten Apotheken an, sich an einem E-Rezept-System beteiligen zu wollen. Für die ab Januar 2022 geplante flächendeckende Einführung von E-Rezepte kann der Einbezug der identifizierten fördernden Faktoren vonseiten der Politik, Softwareentwickler und Verbände eine wichtige Rolle bei der Implementierung spielen.
|
2022-10-07T00:59:13.716Z
|
246,846,587 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12688/wellcomeopenres.17544.3",
"MAG": null,
"PubMedCentral": "8933645"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://wellcomeopenresearch.org/articles/7-52/v3/pdf"
}
|
Background: Air pollution exposure is responsible for a substantial burden of respiratory disease globally. Household air pollution from cooking using biomass is a major contributor to overall exposure in rural low-income settings. Previous research in Malawi has revealed how precarity and food insecurity shape individuals’ daily experiences, contributing to perceptions of health. Aiming to avoid a mismatch between research intervention and local context, we introduced a simple cookstove intervention in rural Malawi, analysing change in fine particulate matter (PM 2.5) exposures, and community perceptions. Methods: Following a period of baseline ethnographic research, we distributed ‘chitetezo mbaula’, locally-made cookstoves, to all households (n=300) in a rural Malawian village. Evaluation incorporated village-wide participant observation and concurrent exposure monitoring using portable PM 2.5 monitors at baseline and follow-up (three months post-intervention). Qualitative data were thematically analysed. Quantitative analysis of exposure data included pre-post intervention comparisons, with datapoints divided into periods of combustion activity (almost exclusively cooking) and non-combustion periods. Findings were integrated at the interpretation stage, using a convergent design mode of synthesis. Results: Individual exposure monitoring pre- and post-cookstove intervention involved a sample of 18 participants (15 female; mean age 43). Post-intervention PM 2.5 exposures (median 9.9μg/m 3 [interquartile range: 2.2–46.5]) were not significantly different to pre-intervention (11.8μg/m 3 [3.8–44.4]); p=0.71. On analysis by activity, background exposures were found to be reduced post-intervention (from 8.2μg/m 3 [2.5–22.0] to 4.6μg/m 3 [1.0–12.6]; p=0.01). Stoves were well-liked and widely used by residents as substitutes for previous cooking methods (mainly three-stone fires). Commonly cited benefits related to fuel saving and shorter cooking times. Conclusions: The cookstove intervention had no impact on cooking-related PM 2.5 exposures. A significant reduction in background exposures may relate to reduced smouldering emissions. Uptake and continued use of the stoves was high amongst community members, who preferred using the stoves to cooking over open fires.
|
2022-10-14T01:06:00.368Z
|
246,520,647 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5772/intechopen.102325",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://doi.org/10.5772/intechopen.102325"
}
|
Healthcare is an essential service in smart cities. To deploy healthcare systems in such cities, personal health monitoring systems, infrastructure for collecting and delivering individual data, and a system for diagnosing symptoms are required. For the first requirement, wireless body area networks (WBANs) have recently received considerable attention from research communities. Owing to their main distinguishable features from general wireless sensor networks, research challenges regarding WBANs have been focused on network topology around the body and implanted nodes, efficient resource allocation, and power control. In this chapter, we provide a comprehensive discussion on the emerging research trends in the area of wireless sensor networks and a discussion of WBANs in terms of their resource allocation.
|
2022-11-20T14:27:44.636Z
|
41,158,052 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/AO.44.004136",
"MAG": "2083778239",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We propose a versatile guided-wave geometry encompassing electro-optic control for signal routing. A zero-gap directional coupler in liquid crystal can switch between two output states in the guide plane, permitting signal rerouting with modulation voltages as small as 70 mV. In the absence of an applied bias, no guiding--hence no modal output--is provided by the structure.
|
2022-12-21T19:19:54.610Z
|
145,419,876 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0144686X06004818",
"MAG": "2097858449",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The contemporary discussion about the growing ‘burden of population ageing’ should not neglect the substantial productive potential of older people. Using micro-data from the 2004 Survey of Health, Ageing and Retirement in Europe (SHARE), this paper examines the relationships between selected socio-demographic characteristics and the rates of participation in voluntary work in 10 European countries among those aged 50 or more years. The analysis reveals a clear spatial pattern, with relatively high participation rates in Northern Europe and relatively low participation rates in Mediterranean countries, and shows that age, education, health and involvement in other social activities strongly influence an individual's propensity to engage in volunteer work. A multivariate logistic regression provided no indication that the country differences can be explained by variations in population composition or attributes, such as the age structure or differences in health status. The findings have important implications for future cross-national research and for policies to promote the participation of older adults in voluntary work, and suggest that policies and programmes to encourage older citizens to make greater use of their productive capacities are feasible. It is concluded that further research needs to account for the influences of institutions and culture on participation in volunteering, the finding of this paper.
|
2022-12-26T22:00:05.126Z
|
121,755,894 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1121/1.4708311",
"MAG": "2048818415",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Teaching as a science: As part of the endless pursuit of teaching excellence faculty develop and each year modify course materials in an attempt to help students learn as much science as possible in a semester. The goals include teaching the content as well as an appreciation for the science and how it connects to our everyday lives. At the same time we expect our students to learn what it is to do science and be a scientist. How can we measure the effectiveness of our teaching methods and compare them from year to year and from university to university? Since the mid-90's physics instructors have been using the FCI (Force Concept Inventory) to measure something, conceptual understanding maybe, in first semester introductory physics. Many other conceptual inventories have followed. In 2005 the CLASS was developed to measure student's perceptions and beliefs about learning physics. Quite often faculty are surprised and disappointed in the outcomes of these measures. As a colleague so eloquently stated, “St...
|
2022-02-09T19:49:13.781Z
|
12,480,129 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7748/ns.10.5.45.s39",
"MAG": "2515845753",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
I would like co make a few comments on, Research shows that shiftwork can damage your health' (Editorial October 11).
|
2022-02-13T04:25:31.571Z
|
82,063,813 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21236/ada382518",
"MAG": "1578274886",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Abstract : The evolution of solid tumors involves acquisition of genetic abnormalities, which result in changes in both the set of genes expressed and the relative levels of gene expression. However, the increasing number of candidate genes whose expression needs to be evaluated for prognostic, diagnostic, therapeutic, or research purposes will require obtaining material from numerous tissue sections. Therefore this proposal is motivated by the need for more effective use of clinical specimens, and will address the problem of obtaining sufficient and cell type specific mRNA from clinical breast tumor specimens. This will entail adapting/developing procedures to amplify with fidelity the mRNA repertoire expressed in small numbers of normal, pre-cancerous and malignant breast epithelia. To this end, in this project period, we have concentrated effort on establishing and validating microarray-based assays for measuring gene expression levels and have demonstrated the capability to isolate and amplify mRNA from cultured cells. Realization of these objectives will allow, in the future, development of a resource, consisting of amplified mRNA populations from individual cells from normal and tumor material, that can be used for evaluation of the prognostic, diagnostic and/or therapeutic importance of genes expressed in breast cancer.
|
2022-02-11T02:18:15.570Z
|
251,364,443 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31004/basicedu.v6i4.3414",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYSA",
"status": "GOLD",
"url": "https://doi.org/10.31004/basicedu.v6i4.3414"
}
|
This study aims to analyze the effect of character and personality education on students' self-confidence levels and emphasizes the importance of coaching and continuity in education. This study uses a quantitative method with a descriptive analysis approach. The data used are primary. Data were collected using research instruments. The research subjects were D3 Midwifery students in the first semester. Based on the results of data and analysis, it can be concluded that most of the D3 Midwifery students in the first semester of Health Polytechnic have a sufficient level of confidence, meaning that midwifery students still need to develop self-confidence through continuous coaching and guidance so that they have confidence. Especially in decision making and relationships with patients and the community.
|
2022-08-08T12:40:40.500Z
|
163,821,784 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0364009414000269",
"MAG": "2317996349",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ascetic systems commonly exhibit some sort of conflict between spiritual pursuits and mundane needs. This article contextualizes the particular rabbinic dilemma of study versus sustenance within the broader context of the Zoroastrian tradition and its critique of the Manichaean Elect. The rabbis shared with their Zoroastrian contemporaries not only the perception of a religious tension between agriculture and the pursuit of religious studies, but also a multifaceted array of possible solutions that attempt to harmonize, mitigate, or otherwise resolve this theological and practical tension. While the basic conflict between study and sustenance is already formulated in tannaitic works, it is argued that the unique perspective offered by the Babylonian Talmud engages, and perhaps reacts to, the Iranian tradition.
|
2022-09-05T05:11:28.869Z
|
119,583,323 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVB.14.2910",
"MAG": "1972690972",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The phonon contribution to the heat capacity has been calculated for 'He on Xe; for Ne on Ar, Kr, and Xe; for Ar on Kr and Xe; and for Kr on Xe. These are, to our knowledge, the first such calculations for real systems. In each case, a model was taken in which the substrate has a perfect (100) surface and the adsorbate goes down as a solid monolayer in registry with the substrate. The quasiharmonic approximation was used, and the results for Ne adsorbates were considerably different from those obtained in the harmonic approximation, because the large zero-point vibrations of the Ne atoms produce a substantial expansion normal to the surface. We find that the quasiharmonic approximation does not even exist for He on Ne, Ar, and Kr, or for 'He on Xe, just as it does not for bulk 'He or 'He. For several cases, including 'He on Xe, the calculated heat capacity becomes slightly negative at low temperatures.
|
2022-09-05T20:31:07.387Z
|
252,238,687 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.37399/issn2072-909x.2022.7.43-49",
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"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The object of the research is the practice of selection of candidates for the state service of the Russian empire, legal registration of this practice and influence of the national and confessional belonging, especially Jewish (Judaism) and to some extent Polish on the results of the selection. The subject of the research is the legislation of the Russian Empire, by-laws, the existing practice of staffing in various departments and services, as well as projects to address the “Jewish question” by prominent Russian statesmen. The author considers in detail the emergence of restrictions on the rights of Jews and attempts of the government to eliminate the contradiction between the desire not to allow Jews to enter public service in general, and the need for qualified specialists, primarily doctors. Particular attention is paid to the practice of prohibiting the service of Jews and Poles in the Russian special services: the Separate Corps of Border Guards and the Separate Corps of Gendarmes. A comparative legal analysis of the Gorodovaya Provisions made it possible to note the increase in anti-Semitism during the reign of Alexander III. The main conclusions of the research are the impossibility to solve the national, including Jewish and Polish, question under the conditions of Great Russian chauvinism, typical for many members of Russian government and emperors. The novelty of the study lies in the comparison of two opposite ways of achieving the same goal, formulated by the highest officials of the empire.
|
2022-09-15T18:31:40.558Z
|
234,928,660 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TCSS.2021.3070220",
"MAG": "3153612359",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Mobile crowdsensing (MCS) has heated up and has become a new paradigm of data collection. In the process of the task allocation of MCS, users are often required to provide their own location information with the server to conveniently dispatch some suitable tasks to them. However, it is possible for malicious servers to infer some sensitive information based on the user’s location such as the user’s home address or the user’s trajectory and so on which will cause serious privacy issues. Recently, differential privacy (DP) has become a promising privacy protection scheme. However, the existing DP schemes in location privacy protection for MCS do not pay attention to the accuracy of task allocation as equally as the effects of privacy protection, which often results in the task allocation to be inaccurate and inefficient. In order to overcome the shortcoming, we propose a novel MCS task allocation scheme integrating the mapping accuracy of task-worker with the privacy-preserving effect on the user’s location. Besides edge devices, its implementation system consists of a task allocation server and a third party, both of which are semitrusted, that is, both of them only know about the user’s rough location information but cannot obtain the user’s exact location. At first, to improve the response speed of MCS task requests and the location privacy protection of MCS users, our scheme can exploit more than one edge-computing node nearby a user to cooperatively participate in MCS task allocation by aggregating him/her and the near users into groups. Then, our scheme can further enhance the location privacy protection effect based on the Johnson–Lindenstrauss (JL) transformation, which can achieve accurate task allocation and hold the merits of DP. Finally, we verify the feasibility by some experiments based on two data sets. The performance is compared with that of $t$ he typical DP. The results show that our scheme not only provides strict privacy guarantees but also has higher performance.
|
2022-11-27T23:09:29.738Z
|
4,379,974 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/jvim.15043",
"MAG": "2791565430",
"PubMedCentral": "5867011"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.15043"
}
|
This consensus statement update reflects our current published knowledge and opinion about clinical signs, pathogenesis, epidemiology, treatment, complications, and control of strangles. This updated statement emphasizes varying presentations in the context of existing underlying immunity and carrier states of strangles in the transmission of disease. The statement redefines the “gold standard” for detection of possible infection and reviews the new technologies available in polymerase chain reaction diagnosis and serology and their use in outbreak control and prevention. We reiterate the importance of judicious use of antibiotics in horses with strangles. This updated consensus statement reviews current vaccine technology and the importance of linking vaccination with currently advocated disease control and prevention programs to facilitate the eradication of endemic infections while safely maintaining herd immunity. Differentiation between immune responses to primary and repeated exposure of subclinically infected animals and responses induced by vaccination is also addressed.
|
2022-12-18T09:15:09.125Z
|
252,639,485 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/agronomy12102337",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2073-4395/12/10/2337/pdf?version=1664358532"
}
|
We aimed to monitor the species diversity and the dynamics of the number of soybean pests using light traps with an original design to develop protection systems against the main phytophages. Traps lured 44 species of insects from eight orders and 27 families. The capture of 15 species of economically important phytophages was recorded—representatives of various orders and families: order Lepidoptera—Noctuidae, Crambidae, Erebidae, and Geometridae; order Hemiptera—Flatidae; order Coleoptera—Elateridae, etc. Insect identification was carried out via morphological methods. Over the study period (93 days), 4955.41 insect specimens were caught on average per one trap. Most of the attracted insects belong to harmful entomofauna: namely the cotton bollworm (Helicoverpa armigera, Hübner)—58.9%, the beet webworm (Loxostege sticticalis, L.)—12.74%, the nutmeg moth (Anarta trifolii, Hufnagel)—6.5%, the European corn borer (Ostrinia nubilalis, Hübner)—2.68%, and some other species—19.2%. In addition to economically significant phytophages, we registered some indifferent and beneficial species. The summer dynamics of the cotton bollworm and the nutmeg moth were obtained for the entire research period. Then, we calculated the values of the indices of biodiversity and the dominance of insect species. An analysis of the index values allows us to conclude a balanced entomocomplex at the research site.
|
2022-10-01T16:50:10.088Z
|
211,025,135 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21037/ATM.2019.09.131",
"MAG": "2979345502",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Because renal cell carcinoma (RCC) patients are likely to have substantial comorbidities due to advanced age at the time of diagnosis, it is important to explore the effects of preexisting medical diseases on survival after definitive surgical treatment (1). Several epidemiological studies have detected a significant association between RCC prognosis and metabolic syndrome components, such as obesity, hypertension, diabetes mellitus (DM), and dyslipidemia (2-5).
|
2022-02-08T03:18:21.819Z
|
109,993,949 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/AMR.649.93",
"MAG": "2036615184",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The main subjects of the thesis are new materials and assessment of ventilation efficiency floors. As we are working with old buildings most of all, in most cases waterproofing is not working and simply it is missing. The rising humidity can, without any problems, penetrate higher to the brickwork or flooring above. Therefore we need a suitable solution. Software CFD is capable of flow visualisation which is then used as the base for the ventilation efficiency assessment.
|
2022-02-10T05:30:42.648Z
|
143,873,552 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1504/IJPEE.2013.060177",
"MAG": "2016441626",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, we review the macroeconomics curriculum dominantly used in Indian universities and suggest its radical overhaul. The macroeconomics taught in Indian universities is based on the theoretical structure used to discuss the macroeconomics of the developed countries and which do not address the stylised macroeconomic facts of India. Given the status of contemporary macroeconomics as a theoretical space for grounding policy debates, we argue that we need a relevant macroeconomics curriculum that take into account the institutional features of the Indian economy. In this context, we contrast neoclassical, Keynesian and Marxist approaches to the twin problems of accumulation and subsistence, which we identify as the main policy objectives. We argue for a more pluralistic approach to teaching of macroeconomics.
|
2022-02-09T07:17:37.494Z
|
253,661,803 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1079/cabicompendium.109473",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This datasheet on Lampyris noctiluca covers Identity.
|
2022-11-19T18:29:28.731Z
|
24,961,998 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1167/IOVS.04-1086",
"MAG": "2025071718",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
PURPOSE
To determine whether experimentally measured upper and lower eyelid saccades can be fitted to a mathematical function.
METHODS
A charge-coupled device video camera connected to a personal computer was used to record upper and lower eyelid saccades accompanying 20 degrees and 40 degrees of vertical eye rotation in 19 normal adult subjects. Movement analysis was performed with software that calculated the center of a blue spot in each frame. The damped harmonic oscillator model was used to fit all saccadic functions obtained.
RESULTS
All downward and upward saccades of both upper and lower eyelids were fitted with the underdamped solution of the model with correlation coefficients ranging from 0.980 to 0.999 (mean = 0.995). It was possible to measure maximum velocity at any time, amplitude, and duration of the saccade movements. For the upper eyelid, downward saccades were faster than upward saccades, a difference that was not observed for the lower eyelid. For both the upper and lower eyelids, the velocity of upward and downward movements reached a peak at approximately 0.05/0.06 second and then decreased. For both the upper and lower eyelid saccades, there was good linear correlation between amplitude and velocity. Overshoots were detected in the downward saccades of both lids.
CONCLUSIONS
Normal upper and lower saccades are described by functions that are extremely well fitted by the underdamped solution of the harmonic oscillator model. Overshooting is a typical feature of normal downward saccades and can be explained by the elastic properties of the tissues.
|
2022-10-23T16:57:37.307Z
|
253,446,830 |
{
"externalids": {
"ACL": null,
"ArXiv": "2211.05446",
"DOI": "10.48550/arXiv.2211.05446",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
—Faced with the threat of identity leakage during voice data publishing, users are engaged in a privacy-utility dilemma when enjoying convenient voice services. Existing studies employ direct modification or text-based re-synthesis to de-identify users’ voices, but resulting in inconsistent audibility in the presence of human participants. In this paper, we propose a voice de-identification system, which uses adversarial examples to balance the privacy and utility of voice services. Instead of typical additive examples inducing perceivable distortions, we design a novel convolutional adversarial example that modulates perturbations into real-world room impulse responses. Benefit from this, our system could preserve user identity from exposure by Automatic Speaker Identification (ASI) while remaining the voice perceptual quality for non-intrusive de-identification. Moreover, our system learns a compact speaker distribution through a conditional variational auto-encoder to sample diverse target embeddings on demand. Combining diverse target generation and input-specific perturbation construction, our system enables any-to-any identify transformation for adaptive de-identification. Experimental results show that our system could achieve 98% and 79% successful de-identification on mainstream ASIs and commercial systems with an objective Mel cepstral distortion of 4.31dB and a subjective mean opinion score of 4.48.
|
2022-11-16T14:15:13.261Z
|
1,720,124 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/hpm.2144",
"MAG": "1514824253",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
CONTEXT
National and international strategies were implemented in eastern Democratic Republic of Congo (DRC) to address sexual and gender-based violence (SGBV).
OBJECTIVES
The objective was to assess community attitudes of SGBV and health facility capacity to address SGBV in eastern DRC.
DESIGN AND SETTING
The design and setting are as follows: a cross-sectional, population-based cluster survey of 998 adults in eastern DRC territories, a convenience sample of 27 adults using semi-structured directed interviews, qualitative data from 37 focus groups conducted in three health zones, assessment of 64 health facilities and a comparative analysis of SGBV strategies.
MAIN OUTCOME MEASURES
The main outcome measures opinions regarding SGBV prevention and justice and health facility capacity to address SGBV.
RESULTS
The majority of respondents favored the legal system over community mediation to obtain justice for SGBV. However, 61.1% (95% CI, 51.8-70.5%) of SGBV survivors reported being forced to accept community mediation. Among SGBV survivors, 81.2% (95% CI, 74.5-87.8%) reported no available mental health care. Less than half of all respondents reported access to a hospital, clinic or pharmacy. The analyses and facility assessment reinforce the need to improve SGBV care.
CONCLUSIONS
Mixed methodologies point to the complexities of addressing SGBV, assess key elements of SGBV prevention, justice and response, and may ultimately inform national and international strategies.
|
2022-12-16T09:53:07.843Z
|
24,979,930 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/00005382-200110000-00009",
"MAG": "2334239307",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The authors studied 37 consecutive patients with primary Sjögren syndrome and normal chest radiographs. Thin-section CT images were analyzed using a semiquantitative grading system. The presence, distribution, and severity of 9 morphologic parameters were assessed. In 34 patients, CT findings were correlated to pulmonary function tests (PFTs). Abnormal high resolution CT (HRCT) findings were seen in 24 of 37 patients (65%): interlobular septal thickening, n = 9; micronodules, n = 9; ground glass attenuation n = 4; parenchymal cysts, n = 5. Intralobular opacities, honey combing, bronchial wall thickening, bronchiectasis, and pleural irregularities were less frequent. Both HRCT and PFTs were normal in 10 patients. Computed tomography was normal in four patients with PFTs that indicated the presence of small airway disease. High resolution CT abnormalities were found in seven patients with normal PFT. The overall correlation between HRCT and PFTs was poor. High resolution CT and PFTs appear to be sensitive for both the early detection of parenchymal abnormalities and a decreases in lung function in asymptomatic patients with primary Sjögren syndrome. However, abnormal HRCT findings do not necessarily indicate a substantial alteration in PFTs.
|
2022-12-20T06:24:04.325Z
|
52,191,161 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4187/respcare.06321",
"MAG": "2891292873",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://rc.rcjournal.com/content/respcare/63/12/1506.full.pdf"
}
|
BACKGROUND: Regular monitoring combined with early and appropriate use of airway clearance can reduce unplanned hospital admissions for patients with neuromuscular disease (NMD) and spinal cord injury (SCI). We aimed to describe and compare knowledge of guidelines, monitoring of cough effectiveness, clinician prescription/provision of airway clearance strategies, and service provision constraints in the United Kingdom and Canada. METHODS: This was a cross-sectional survey of clinicians affiliated with NMD and SCI clinics in Canada, 2016 attendees at the Home Mechanical Ventilation Conference in the United Kingdom, and United Kingdom physiotherapist networks. RESULTS: We received 155 surveys (92 from Canada; 63 from the United Kingdom). More UK respondents (76%) were aware of airway clearance guidelines than Canadian (56%) respondents (P = .02). Routine assessment of cough effectiveness was reported by more UK respondents (59%) than Canadian (42%) respondents (P = .044). Cough peak flow (CPF) was the most common method used in both countries, although it was more commonly used in the UK (96%) than in Canada (81%, P = .02). Fewer Canadian respondents reported using CPF before initiation of airway clearance (81% vs 94%, P = .046), and fewer Canadian respondents showed results to patients for technique feedback (76% vs 97%, P = .007). Similar participant numbers reported using CPF after initiation to ensure adequate technique (73% vs 72%, P = .92). Mechanical insufflation-exsufflation (MI-E) + lung volume recruitment (LVR) + manually assisted cough when CPF ≤ 270 L/min was most routinely recommended (41% overall). Monotherapy was infrequent (LVR 15%, manually assisted cough 7%, and MI-E 4%). More Canadians identified constraints on service provision, specifically insufficient public funding for equipment (68% vs 39%, P = .002) and inadequate community workers' knowledge (56% vs 34%, P = .002). Funding for community support was a common constraint in both countries (49% vs 42%). CONCLUSIONS: The somewhat variable cough effectiveness monitoring and airway clearance practices identified in this survey confirm the need for further work on knowledge translation related to guideline recommendations and the need to address common constraints to optimal service delivery.
|
2022-08-20T08:58:31.291Z
|
17,277,516 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CLUSTR.2009.5289203",
"MAG": "2150410776",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper we address the problem of distributing rendering computations for real-time display of very large 3D models using a graphics cluster. With a programmable graphics processing unit (GPU) in each node, rendering computations are increasingly carried out in two phases using two separate GPU programs: a vertex shader program for vertex (geometry) processing and a fragment shader program for pixel (color) processing. With fragment shader programs becoming more and more time consuming for increased realism and special visual effects, distributing load solely based on geometry as is done in most contemporary systems can cause significant load imbalance. There is often only a weak correlation between geometry and pixel data distribution, due to multiple factors such as occlusion of objects behind, by objects in front. Clearly, load balancing for geometry processing or pixel processing alone is not optimal. In this paper, we present a novel in-frame two-phase load-balancing technique that distributes data first for geometry and then for pixel processing. The technique is implemented on a graphics cluster and experimental results demonstrate considerable improvements in rendering performance.
|
2022-08-28T10:57:07.766Z
|
143,148,623 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/494124",
"MAG": "1943530555",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ROBERT JAY LIFTON'S NIGHTMARE IS PUZZLING. Since the end of World War II, Americans have engaged in a great debate concerning how best to manage and control nuclear science and technology in the public interest. This debate has become a very significant public policy debate of American history, rivaling the debates over slavery, prohibition, and even civil rights. For more than forty years, Americans have struggled with the dilemma of controlling a science and technology that not only threatens our civilization but also promises great progress. How odd it would be had the academic community missed out on the Great Nuclear Debate.
|
2022-09-08T07:07:36.687Z
|
240,565,901 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.38035/JIHHP.V1I3.683",
"MAG": "3199133007",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Sumber daya manusia (SDM) merupakan faktor penting di dalam suatu organisasi maupun di suatu perusahaan. Hal ini dikarenakan tidak akan berjalannya suatu organisasi ataupun perusahaan apabila tidak ada sumber daya manusia yang baik. Hal itu juga tidak akan berjalan dengan baik apabila tidak adanya manajemen pengelolaan terhadap sumber daya manusia yang berada di suatu organisasi maupun perusahaan. Apapun bentuk serta tujuannya, organisasi atau perusahaan dibuat berlandaskan visi dan misi untuk mencapai tujuan bagi kepentingan manusia dan dikelola oleh manusia pula. Pengelolaan manajemen sumber daya manusia sangat penting untuk dilakukan dan karya artikel ini untuk menjelaskan analisis singkat mengenai upaya manajerial yang seperti apa agar bisa meningkatkan kinerja serta motivasi melalui Reward System agar mencapai kesuksesan di suatu organisasi maupun perusahaan.
|
2022-10-04T14:36:46.323Z
|
248,813,609 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1167/tvst.11.5.14",
"MAG": null,
"PubMedCentral": "9123490"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.1167/tvst.11.5.14"
}
|
Purpose Surgically implanted intraocular lenses (IOLs) may be used as drug-delivery devices, but their effectiveness is not well defined. Computational fluid dynamics models were developed to investigate the capability of IOLs to release drugs at therapeutic concentrations. Methods Models were generated using COMSOL Multiphysics. Primary open-angle glaucoma (POAG) and wet age-related macular degeneration (AMD) were simulated by reducing aqueous vein and choroidal blood flow, respectively. Release of dexamethasone, ganciclovir, or dextran was studied using common IOL materials, polydimethylsiloxane (PDMS) and poly(2-hydroxyethyl methacrylate) (PHEMA). Results Drug clearance proceeds mainly through choroidal blood flow. When fully constricted, maximum concentration at the choroid (Cmax) values increased by 32.4% to 39,800%. Compared to dexamethasone, Cmax in different tissues decreased by 6.07% to 96.0% for ganciclovir and dextran, and clearance rates decreased by 16% to 69% for ganciclovir and by 92% to 100% for dextran. Using PDMS as the IOL reduced clearance rates by 91.3% to 94.6% compared to PHEMA. Conclusions In diseased eyes, drugs accumulate mainly in posterior tissue; thus, choroidal drug toxicity must be assessed prior to IOL implantation in POAG and AMD patients. Moreover, drug properties modulated concentration profiles in all ocular segments. The hydrophobic small-molecule dexamethasone attained the highest concentrations and cleared the fastest, whereas hydrophilic macromolecular dextran attained the lowest concentrations and cleared the slowest. Furthermore, high concentrations were achieved quickly following release from PHEMA, whereas PDMS allowed for sustained release. Translational Relevance In silico results can guide scientists and clinicians regarding important physiological and chemical factors that modulate tissue drug concentrations from drug-eluting IOLs.
|
2022-11-18T17:36:17.941Z
|
30,634,952 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/00001888-200308000-00010",
"MAG": "2112433884",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.lww.com/academicmedicine/Fulltext/2003/08000/Implementing_a_Problem_Based_Learning_Curriculum.10.aspx"
}
|
The authors review the difficulties that Argentina's medical schools, particularly the public ones, are likely to face when implementing a problem-based learning (PBL) curriculum, describe the barriers that were faced by their medical school as it implemented PBL, and point out the implications for medical education in developing countries with conditions and education programs similar to those in Argentina. Specifically, they (1) outline the basic requirements for successful implementation of a PBL curriculum, (2) describe the training contradiction in Argentina between a complex and heterogeneous health care system that forces specialization and medical schools' attempts to train generalists, and (3) review the effects on curriculum change of the size and the training levels of the student population and the availability of human and financial resources. This information indicates the context in which the Rosario University School of Medicine designed a new PBL curriculum and implemented it in 2002. The authors close by suggesting that schools in developing countries that are in circumstances similar to that of Rosario should consider whether a PBL curriculum is even appropriate for them, and should realize the difficulties (discussed in the article) they will have to overcome. Also, uncertainties about the efficacy of PBL create a case for exploring alternatives to PBL, including hybrid curricula. Considering the available research on curricular innovations such as PBL and the particular situations of their countries may help schools anywhere avoid wrong decisions about what curricula to implement.
|
2022-12-17T18:01:11.162Z
|
36,373,235 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/hep.23200",
"MAG": "1984281395",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
We conducted a study to characterize the variability in the upper limit of normal (ULN) for alanine aminotransferase (ALT) across different laboratories (labs) in Indiana and to understand factors leading to such variability. A survey was mailed to all eligible labs (n = 108) in Indiana, and the response rate was 62%. The survey queried for ALT ULN, the type of chemical analyzer used, five College of American Pathologists (CAP) sample results, and methods used to establish the reference interval. There was a wide variability in the ALT ULN for both men and women. Eighty‐five percent of labs used chemical analyzers belonging to one of the four brands. For all five CAP samples, there was a statistically significant difference in ALT values measured by different analyzers (P < 0.0001), but these differences were not clinically significant. The majority of labs used the manufacturers' recommendations for establishing their ALT ULN rather than in‐house healthy volunteer testing (only 17%). When healthy volunteers were tested, the process for testing was haphazard in terms of the number of individuals tested, frequency of testing, and criteria for choosing the reference population. After controlling for chemical analyzer type, there was no significant relationship between ALT ULN values and the method used for its establishment. Conclusion: Wide variability in ALT ULN across different labs is more likely due to variable reference intervals of different chemical analyzers. It may be possible to minimize variability in ALT ULN by (1) each lab solely following the manufacturers' recommendations and (2) manufacturers of different analyzers following consistent and rigorous methodology in establishing the reference range. Alternatively, studies should be undertaken to identify outcome‐based reference intervals for ALT. (HEPATOLOGY 2009.)
|
2022-12-20T04:34:16.260Z
|
10,103,386 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2014/175062",
"MAG": "2157684072",
"PubMedCentral": "4036420"
},
"license": "CCBY",
"status": "GOLD",
"url": "http://downloads.hindawi.com/journals/bmri/2014/175062.pdf"
}
|
Mitochondrial dysfunctions are supposed to be responsible for many neurodegenerative diseases dominating in Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). A growing body of evidence suggests that defects in mitochondrial metabolism and particularly of electron transport chain may play a role in pathogenesis of AD. Structurally and functionally damaged mitochondria do not produce sufficient ATP and are more prominent in producing proapoptotic factors and reactive oxygen species (ROS), and this can be an early stage of several mitochondrial disorders, including neurodegenerative diseases. Mitochondrial dysfunctions may be caused by both mutations in mitochondrial or nuclear DNA that code mitochondrial components and by environmental causes. In the following review, common aspects of mitochondrial impairment concerned about neurodegenerative diseases are summarized including ROS production, impaired mitochondrial dynamics, and apoptosis. Also, damaged function of electron transport chain complexes and interactions between pathological proteins and mitochondria are described for AD particularly and marginally for PD and HD.
|
2023-01-01T17:49:25.796Z
|
234,828,274 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1755-1315/714/3/032015",
"MAG": "3154752152",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1755-1315/714/3/032015"
}
|
Based on the concept of molecular design, mesoporous silica materials with different physical structure and morphology were prepared by adjusting the molecular chain length of surfactants and the mass ratio of anion-cationic surfactants. The composition and morphology of the prepared silica materials were characterized by FTIR, SEM, N2 adsorption and desorption. By adjusting the carbon chain length of surfactants and the mass ratio of anion-cationic surfactants, the preparation of mesoporous silica was carried out, and the effects of mesoporous silica on the internal structure of mesoporous silica were analyzed.
|
2022-02-07T21:30:52.962Z
|
84,359,686 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2298/JAS0502117J",
"MAG": "2041237602",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Three fractions of lovage seed: small size 2.5 mm, medium size 3.0 mm, and large size 3.5 mm were analyzed in this paper. Contents of small fraction were 23 %, medium 46 %, and large 31 %. The infraction seed was used as standard. The indicators: germination energy, total germination and seed weight were investigated. The best results had the broadest fraction of 3.5 mm concerning all indicators. The temperature of 20 °C constant proved the most optimum when all indicators had the highest values, and the most unfavorable was the temperature between 5/15 °C 12/12h alternately. Due to conducted investigation, it can be concluded that the contents of the broadest fraction of lovage seed is the most important for production and seed multiplication.
|
2022-04-22T04:59:47.433Z
|
120,166,024 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1121/1.414233",
"MAG": "2008700916",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://asa.scitation.org/doi/pdf/10.1121/1.414233"
}
|
Measurements were made of the propagation of 1‐D nonlinear waves (i.e., Young’s mode) in a bar of Berea sandstone 3.8 cm in diameter and 1.8 m long. Both waveforms (time domain) and spectra (frequency domain) were measured. The experimental results were then compared with waveforms calculated from a numerical scheme based on the simple wave solution for 1‐D waves in rock using a classical nonlinear equation of state. The numerical solution is written in MATLAB and runs quickly on a small personal computer. Attenuation was added by propagating the waveform a small distance, transforming the waveform into the frequency domain, and applying the attenuation, and then transforming back into the time domain and propagating the new waveform. The same method was applied earlier for nonlinear propagation of a sound wave in a tube of air by Pestorius and Blackstock. The experiments and simulations clearly demonstrate that a classical nonlinear equation of state is incomplete or inappropriate for describing or model...
|
2022-07-31T04:47:40.738Z
|
226,033,177 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.32591/coas.ojer.0401.01001j",
"MAG": "3030053498",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://centerprode.com/ojer/ojer0401/coas.ojer.0401.01001j.pdf"
}
|
policies Abstract Problem solving follows a cycle of inquiry where the individual iterates between finding possible paths and exploring their likely effectiveness before selecting one as a possible solution. The cycle is enhanced through proximal processes because the number of paths that can be explored in depth are greater when more people work on the same problem. This paper discusses the cognitive aspects of problem solving, how proximal processes, specifically collaborations, affect problem solving, and how proximal processes work in formal and game problem solving environments. The primary finding is that proximal processes benefit problem solving mostly by providing explanations, but only when the collaboration is structured so that a lesser-skilled participant in the collaboration is explaining to a higher-skilled participant. This finding is common to both formal and game environments.
|
2022-09-04T17:49:13.025Z
|
4,333,043 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/15384101.2017.1408235",
"MAG": "2772746286",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/15384101.2017.1408235?needAccess=true"
}
|
The human genome is constantly challenged by genotoxic stress arising from endogenous and exogenous sources, which interferes with proper DNA replication. To counteract such replication stress and protect genome integrity, cells employ a complex DNA damage response (DDR) machinery that encompasses repair pathways to fix different types of DNA damage, and cell cycle checkpoints to provide the time needed to repair DNA lesions [1]. However, unresolved DNA lesions and DNA replication intermediates can persist and be transmitted into the subsequent G1 phase of daughter cells, where they are shielded by the p53-binding protein 1 (53BP1) as nuclear bodies [2]. Consequently, replication stress induced e.g. by genotoxic agents or inhibition of Ataxia telangiectasia and Rad3 related (ATR) kinase increases the number of 53BP1 bodies per cell as well as the subset of cells carrying 53BP1-marked lesions. In this issue of Cell Cycle, Lezaja and Altmeyer elaborate on this concept and link the level of replication stress-induced DNA lesions by inhibition of ATR to the fate of daughter cells [3]. Using 53BP1 and cell-cycle reporter cell lines in time lapse experiments, they find that increasing the number of G1-transmitted DNA lesions leads either to extended quiescence with unresolved 53BP1 bodies or a delay in S-phase entry upon which 53BP1 bodies resolve. Interestingly, DNA damage-induced quiescence and delay in S-phase commitment depend on tumor suppressor p53, as cells without functional p53 abrogated the replication stress-induced prolonged G1 phase. Instead, p53-negative cells enter S phase nearly normally, but with unresolved DNA lesions. This is a critical finding, because p53 is a central part of the DDR barrier that is frequently mutated in human cancers [4]. Generally, p53 delays the G1/S transition by directly driving the expression of p21 (CDKN1A), an inhibitor of cell-cycle-promoting CDK kinases. Consistently with such concept, Spencer et al. reported that two populations of cells exist after mitosis: one that rapidly commits to S phase, and one that enters a transient state of quiescence [5]. This study furthermore showed that quiescence depends on the presence of p21, which itself is subject to regulation by mitogens before mitosis [5]. Moreover, a complementary recent work demonstrated that activation of p53 before mitosis is a critical step for DNA damage-induced quiescence in daughter cells. The half-live of p53 increases to over 7 hours in the presence of DNA damage, ensuring transfer of p53 activity into and de novo expression of p21 in daughter cells [6]. Notably, the anti-proliferative function of p21 in daughter cells thereby competes with the mitogen-driven expression of proproliferative cyclin D1. This leads to a scenario, where access to increasing amounts of serum and epidermal growth factor (EGF) can counteract DNA damage-induced quiescence. The underlying mechanism for this phenomenon is likely a raising threshold of p21 abundance that is needed to block S-phase entry, as cells that escaped quiescence showed a higher cyclin D1/p21 ratio. Supporting data come also from a study which recently showed that p21 levels and a subsequent proliferationquiescence decision correlate with DNA lesions in daughter cells in the presence of mitogens [7]. Here, cells with low and intermediate p21 levels in G1 can enter S phase, while cells with high p21 levels remain in quiescence and harbour unresolved DNA lesions. Similar to observations by the Altmeyer laboratory [3], Arora et al. also just described three major daughter cell populations that enter the next cell cycle with different kinetics. By combining CDK2 activity with 53BP1 reporter cells, they correlate the amount of DNA lesions transmitted through mitosis to the cell cycle behavior in daughter cells by categorizing into: i) proliferating (low amount of 53BP1 bodies), ii) quiescent to proliferating (moderate amount of 53BP1 bodies), and iii) quiescent (high amount of 53BP1 bodies) cell populations [8]. Interestingly, they also found that cells of the ‘quiescent-to-proliferative’ population, which show delayed S-phase entry, can pass the decision to postpone proliferation onto subsequent cell cycles. Collectively, the data put forward by Lezaja and Altmeyer and the complementary studies discussed here, show that replication stress in mother cells has impact on cell cycle kinetics of their daughters, if unrepaired DNA lesions get passed on through mitosis. A cell-to-cell heterogeneity in cell-cycle lengths within cell cultures had been noticed for a long time and these studies now shed new light on basic cell cycle control. Ultimately, a model emerges, where the previous S phase can be seen as the beginning of the cell cycle, ending with the
|
2022-12-10T14:25:08.327Z
|
76,829,275 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/pdi.2019",
"MAG": "2408695774",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This case displays the difficulty of managing type 1 diabetes with young‐onset dementia, withco‐existing medical challenges that have an effect on each other.
|
2022-01-27T20:47:53.371Z
|
72,712,349 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1365-2044.1994.TB04439.X",
"MAG": "2079159456",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
determined. However, from changes made to the design of this product over the years it can be ascertained that this product was produced more than 3 years ago. Since this product was manufactured we have made extensive modifications to the printing operation. This is now a fully automated process which has eliminated the risk of this defect recurring. I would like to apologise for any inconvenience caused and fully endorse Dr Pritchard’s recommendations for checking all anaesthetic equipment before use.
|
2022-10-07T00:04:05.148Z
|
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