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71,788,061 |
{
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"DOI": "10.1046/J.1365-2508.1996.00229.X",
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There are many procedures described for the treatment of vaginal vault prolapse. This paper describes the use of minimal access surgical techniques, in the form of laparoscopic sacrocolpopexy, for the treatment of this condition. The outcomes for the first 29 women to have undergone this procedure are described. Of the operations, 26 were completed without any intra-operative problems. On two occasions the bladder was perforated during the procedure, and in one case the inferior epigastric artery was injured. One patient had a urinary tract infection postoperatively. The remaining patients had uneventful postoperative courses. Most patients were discharged home on the 2nd postoperative day. All patients were reviewed at 2 weeks and at 6 weeks, and 28 have been reviewed at 3 months and at 6 months, and 14 for greater than 6 months, following surgery. All patients have been able to return to their normal lifestyle very rapidly and there were no reports of dyspareunia. There were eight cases of rectocoele at the 6-month review, and one patient had a recurrence of vault prolapse. Four patients have required a further surgical procedure, namely posterior repair. All except one patient had good support of the vaginal vault.
|
2022-07-25T14:38:12.997Z
|
241,414,766 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.35940/ijitee.l2926.1081219",
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},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.35940/ijitee.l2926.1081219"
}
|
In today's world of development any individual is in need of developing the employability skills in order to grow and settle in their profession. Their possession of hard skills such as education, experience and expertise does not guarantee them perfect job opportunities. Low proficient learners from Arts and Science Colleges find it difficult to get reasonable jobs because they lack employability skills. This is an attempt to analyze the role of technology in the development of employability skills particularly English vocabulary in the low proficient learners of Arts and Science College. 20 students from 3 different departments were given assignments to be done using 3 online tools. Assessment has been made to find out some difference in training the low proficient learners from Arts and Science. The result shows a tremendous change in attitude in learning vocabulary in the low proficient learners from Arts and Science. English vocabulary can be. The soft skills syllabus prescribed can be enriched and made more interesting especially for the low proficient learners with the addition of the online tool ‘Memrise” for learning vocabulary. This will pave a path to those that found learning English difficult.
|
2022-07-31T05:24:47.761Z
|
84,028,528 |
{
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"ArXiv": null,
"DOI": "10.4217/OPR.2003.25.3.237",
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"url": null
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|
The temporal dynamics of the meiofauna community in Marian Cove, King George Island were observed from January 22 to October 29 1996. Generally, 14 taxa of metazoan meiofauna were found. Nematodes were dominant comprising 90.12% of the community, harpacticoid 6.55%, and Kinorhynchs 1.54%. Meiofauna abundance increased monthly from January to May 1996, while varying in abundance after August 1996. Overall mean abundance of metazoan meiofauna was during the study periods, which is about as high as that found in temperate regions. Nematodes were most abundant representing . Mean abundance of harpacticoids, including copepodite and nauplius was by kinorhynchs . The overall abundance of other identified organisms was Other organisms consisted of a total of 11 taxa including Ostracoda , Polycheata , Oligochaeta , and Bivalvia . Additionally, protozoan Foraminifera occurred at the study area with a mean abundance of . Foraminiferans were second in dominance to nematodes. The dominant taxa such as nematodes, harpacticoids, kinorhynchs and the other tua were trained and extensively scattered in the map through the Kohonen network. The temporal pattern of the community composition was most affected by the abundance dynamics of kinorhynchs and harpacticoids. The neural network model also allowed for simulation of data that was missing during two months of inclement weather. The lowest meiofauna abundance was found in August 1996 during winter. The seasonal changes were likely caused by temperature and salinity changes as a result of meltwater runoff, and the physical impact by passing icebergs.
|
2022-08-28T16:44:36.238Z
|
251,773,402 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICMEW56448.2022.9859353",
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}
|
Incorporating depth information into RGB images has proven its effectiveness in semantic segmentation. The multi-modal feature fusion, which integrates depth and RGB features, is a crucial component determining segmentation accuracy. Most existing multi-modal feature fusion schemes enhance multi-modal features via channel-wise attention modules which leverage global context information. In this work, we propose a novel pyramid-context guided fusion (PCGF) module to fully exploit the complementary information from the depth and RGB features. The proposed PCGF utilizes both local and global contexts inside the attention module to provide effective guidance for fusing cross-modal features of inconsistent semantics. Moreover, we introduce a lightweight yet practical multi-level general fusion module to combine the features at multiple levels of abstraction to enable high-resolution prediction. Utilizing the proposed feature fusion modules, our Pyramid-Context Guided Network (PCGNet) can learn discriminative features by taking full advantage of multi-modal and multi-level information. Our comprehensive experiments demonstrate that the proposed PCGNet achieves state-of-the-art performance on two benchmark datasets NYUDv2 and SUN-RGBD.
|
2022-09-01T13:18:54.895Z
|
44,732,916 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1365-4632.2010.04770.x",
"MAG": "2112547878",
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"license": null,
"status": null,
"url": null
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|
The third of this three‐part series on water‐related sports dermatoses discusses skin changes seen in athletes who participate in sporting activities on top of or nearby water. While also susceptible to several of the freshwater and saltwater dermatoses discussed in parts one and two of the series, these athletes may present with skin changes unique to their particular sports. This updated and comprehensive review details those near‐water dermatologic conditions commonly seen in sailors, rowers, fishermen, surfers, windsurfers, rafters, and water skiers, and will serve as a guide for dermatologists, sports medicine physicians and other medical practitioners in recognition and treatment of these conditions.
|
2022-09-07T12:36:38.052Z
|
239,038,495 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/tpwrs.2021.3101664",
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}
|
This paper presents a method for the development of galloping distribution maps. The number of galloping days and return period are utilized to deal with the problems of lack of operational experiences for those area without transmission lines, and let the proposed maps be suitable for transmission lines with different voltages. By employing the proposed method, the galloping distribution map can estimate the galloping probability of overhead transmission lines in a more reasonable and accurate manner.
|
2022-09-17T15:43:20.798Z
|
235,383,212 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fendo.2021.575565",
"MAG": null,
"PubMedCentral": "8222995"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fendo.2021.575565/pdf"
}
|
The use of Radiofrequency thermoablation (RFA) for treating large thyroid nodules is limited by the modest efficiency of the available systems in terms of volume of the ablation zones (AZs). This increases the risk of incomplete ablation of the nodule. Systems employing perfused electrodes have been developed to increase the volume of the AZ. Aim of this study is to compare the size of the AZ induced by RFA systems using internally cooled perfused vs. non-perfused electrodes in swine thyroids. RFAs were performed on 40 freshly isolated swine thyroids using both systems. The perfused system was tested using 0.9% saline, 7% and 18% hypertonic saline solutions. Energy delivery to the tissue was stopped when tissue conductivity dropped (real life simulations) and after an established time of 20 seconds (controlled duration). Following RFA, thyroids were transversally and longitudinally cut. Photographs were taken for macroscopic morphometry of the ablated zones before and after formalin fixation, to evaluate tissue shrinkage. Microscopic morphometry was performed on PAS stained sections. In real life simulation experiments, gross morphometry revealed that AZs produced with electrodes perfused using 7.0% saline are larger compared to isotonic saline. Microscopically, all the conditions tested using the perfused system produced larger AZs compared to non-perfused system after 20 seconds of RFA. In conclusion, the perfusion with 7.0% NaCl solution increased the electrical conductivity of the tissue in real life simulations, resulting in larger ablated areas compared to the use of isotonic saline.
|
2022-11-12T03:19:49.137Z
|
108,889,782 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2514/1.144",
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}
|
The present paper addresses both active-flow-control actuator technology development and the demonstration of the effectiveness of actuators that could be easily integrated into practical aircraft applications. The actuator used is an adaptation of the Hartmann oscillator. Demonstration experiments that illustrate the effectiveness of this actuator include cavity tone suppression at transonic speeds and the reduction of jet-impingement tones. The actuator concept is based on a high-speed jet aimed at the mouth of a cylindrical tube closed at the other end. The result is a high-amplitude self-sustaining fluctuating field accompanied by an intense narrowband tone, all in the region between the supply jet and the resonance tube. Using unsteady pressure sensors and flow visualization, we explored the effect of varying actuator parameters such as the spacing between the power jet and the resonance tube, supply pressure, resonance-tube depth, diameter, shape, and lateral spacing. By varying the depth of the tube, the frequency could be varied from about 1.6 kHz to over 10 kHz and amplitudes as high as 156 dB (microphone location dependent) were obtained in the vicinity of actuation. To integrate this concept into practical aircraft applications, two generations of a more complex version of this device known as the powered resonance-tube bank (PRTB) were developed and demonstrated. Results indicate that by using high-frequency excitation at 5-kHz suppression levels in excess of 20 dB were consistently obtained over a range of operating conditions in both cavity and impingement flow situations. Based on our results, we have grounds to believe that a properly designed PRTB has significant advantages over conventional actuators such as acoustic, piezo, and oscillatory microstructures.
|
2022-12-28T18:44:42.387Z
|
167,006,372 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7232/IEMS.2014.13.2.221",
"MAG": "1486575867",
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"url": null
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|
With the progress and prosperity of commerce and industry, time and money increasingly form an equal partnership. Using air carriers to shorten the round-trip time has become an important choice for many people in the tourism process. Faced with increasing competition within the aviation service environment, airline evaluation criteria and the requirements of customers are gradually dominating the evaluation mechanism for air transport service quality. Over the past few years, attention on the transport quality of service has been primarily focused more on land-based transport, and less on the relevant evaluation criteria of airlines. Many studies have shown that quality of service will directly affect customer satisfaction, resulting in the fact that good quality aviation services have become increasingly important. Therefore, in practical industrial operations with limited resources, there is an urgent need to delve into the assessment guidelines that have an impact on customers when they choose an airline, which can be used as a basis for improving customer satisfaction. Through a literature review and a reliability and validity analysis, this study summarized 19 evaluation criteria, using the purposive sampling method and the decision laboratory method (DEMATEL). In addition, this study viewed the causal relationship between the evaluation criteria and the degree of association as a continuing project for airlines. This study selected appropriate empirical samples from two domestic airlines. The conclusions may provide recommendations for all airlines.
|
2022-07-31T07:53:23.503Z
|
10,285,396 |
{
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"ArXiv": null,
"DOI": "10.1109/TPS.2013.2288333",
"MAG": "1971615206",
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"url": null
}
|
In this paper, a compact rep-rate GW pulsed power generator is developed. First, its three key subsystems are theoretically analyzed, engineering designed, and experimentally investigated, respectively. The emphases are put on these four problems: the theoretical analysis of the voltage distribution across the conical secondary windings of the high-coupling transformer, the investigation of the high energy storage density dielectric used in the pulse forming line, the choice of the gas flow velocity of the gas blowing system, and theoretical analysis of the passive stability of the pulsed power generator operated in rep-rate mode. Second, the developed pulsed power generator is described in detail. It has a 0.2-m diameter, a 1.0-m length, and a 20- Ω wave impedance. Across a 100- Ω resistive dummy load, it can steadily operate at a 300-kV output voltage in 50-Hz rep-rate and 250 kV in 150 Hz without gas blowing system. The average power is ~ 1 kW. Finally, the pulsed power generator is applied to drive a relativistic backward-wave oscillator, generating a high-power microwave with peak output power of 200 MW and duration (full-width at half-maximum) of 5 ns in 150-Hz rep-rate. These efforts set a good foundation for the development of a compact rep-rate pulsed power generator and show a promising application for the future.
|
2022-10-06T15:31:34.598Z
|
34,787,382 |
{
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"ArXiv": null,
"DOI": "10.1029/2010WR009248",
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|
Climate change has the potential to reduce water resource availability in the Nile Basin countries in the forthcoming decades. We investigated the sensitivity of water resources to climate change in the Lake Tana Basin, Ethiopia, using outputs from global climate models (GCMs). First, we compiled projected changes in monthly precipitation and temperature in the basin from 15 GCMs. Although the GCMs uniformly suggest increases in temperature, the rainfall projections are not consistent. Second, we investigated how changes in daily temperature and precipitation might translate into changes in streamflow and other hydrological components. For this, we generated daily climate projections by modifying the historical data sets to represent the changes in the GCM climatologies and calculated hydrological changes using the Soil and Water Assessment Tool (SWAT). The SWAT model itself was calibrated and validated using the flows from four tributaries of Lake Tana. For the Special Report on Emissions Scenarios A2 scenario, four of the nine GCMs investigated showed statistically significant declines in annual streamflow for the 2080–2100 period. We interpret our results to mean that anthropogenic climate changes may indeed alter the water balance in the Lake Tana Basin during the next century but that the direction of change cannot be determined with confidence using the current generation of GCMs.
|
2022-12-07T21:14:52.302Z
|
87,801,223 |
{
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"ArXiv": null,
"DOI": "10.2307/2424208",
"MAG": "2328670315",
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|
A study was conducted from July 1965 to September 1966 on the biology of Gunnison's prairie dog (Cynomys gunnisoni gun- nisoni) in South Park, Park Co., Colorado. Prairie dogs within the colony were loosely organized into clans with adult females playing the major role in caring for the young and! warning of danger. Clan bound- aries were not patrolled or defended by clan members, but individual burrows, burrow systems or food supplies were protected by individual animals. Little aggression was observed within the clans but members of different clans would engage in disputes when they encountered each other in the common feeding areas. Females had a high ratio of suc- cessful pregnancies or uterine implantation sites, but mortality caused by a plague (Yersinia pestis) epizootic resulted in the extinction of the main study colony by the spring of 1967. Mean weights of adult males were significantly higher than weights of adult females. Weights of pups in- creased during the first summer so that by September a few individuals were as large as smaller adults. Immigration and emigration were not important in the colony and the only known successful predators were badgers and red-tailed hawks. Tactile, visual and vocal communication was important in the colony, but in general social behavior was not as well developed as in black-tailed prairie dogs. Prairie dogs were diur- nal with two periods of maximum surface activity. Gunnison's prairie dogs completely terminated surface activity for 7 months during the cold seasons of the year, with pups being the last animals to hibernate. Gun- nison's prairie dogs did not work or shape their mounds and their activ- ity had little visible impact on their environment. Most of the time the animals spent aboveground was occupied in eating or searching for food. Grasses were the preferred foods but a variety of forbs were also utilized.
|
2022-12-14T16:33:15.432Z
|
144,219,721 |
{
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"DOI": "10.1353/ANQ.2013.0010",
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|
The theme of mutuality has lately emerged in anthropology by the hand of some of our most influential contemporary thinkers. Yet they explore it in apparently unrelated guises: in the work of Johannes Fabian (2001, 2007) or of Michael Carrithers (2005), mutuality emerges as a methodological preoccupation in discussions about fieldwork ethics referring to the way in which anthropologist and informant are engaged in processes of co-responsibility1; by the hand of Marshall Sahlins (2011a), mutuality is a constitutive principle in personal ontogeny that allows for a theoretical re-founding of kinship studies. Are the two meanings simply unconnected or do they share something in common which may turn out to be of theoretical relevance for contemporary anthropology? In this essay, I aim to show that both meanings are indeed relevantly interrelated but, in order to do so, I find it necessary to explore further Marilyn Strathern's proposals concerning the intrinsic plurality of persons. Mutuality would be the movement between singularity produced out of plurality and plurality produced out of singularity-and that is why it implies "co-presence" to use Sahlins' term or "participation" to use Levy-Bruhl's.Ethnographic Mutuality in Fabian's WorkIn his well-known essay "Ethnographic Misunderstanding and the Perils of Context," Fabian provides us with one of the best definitions of ethnographic mutuality in the literature: "the promise of nontrivial understanding that is produced by researcher and researched together" (1995:47). In short, an unavoidable aspect of all fieldwork interaction would be the occurrence of a feeling of shared revelation. In our present world of almost instantaneous globalization, even more so than in the past, the ethnographer's presence in the field, as well as what she eventually comes to write about it, has an impact on the field but, more than that, it corresponds to processes of joint discovery. A superb example of this is provided by Michael Carrithers when he describes a conversation he had with a group of men during his fieldwork among Jains in India:they thought themselves independent, since they ran their own businesses and were not, as I was, subservient to an institution and to the will of others; I thought myself independent because I could pursue my research interests and not be bound to the drudgery and anxiety of Indian commerce. We never agreed, but we did understand for immediate purposes. We also managed, though with more strain and evasion on my part, to agree to differ about Western eating habits versus their vegetarianism, which for them touches very closely the selfevident practices of Jain living. But in either case it is the very conversation itself, with its mutual understanding and its differing views, that illustrates my point. Here is an ad hoc morality of mutual recognition, mutual trust, and mutual forbearance which arises more or less spontaneously in the course of interaction, in some part because of and in greater part despite our cultural differences. (2005:438)In passages such as this one, we can see how the typical preoccupation of the young ethnographer of being lied to by the informants soon gives way, in the more seasoned ethnographer, to what one might call a Rashomon fascination: the awareness that there is no end to interpretation and that we will ever be working on processes where absolutes play no role. Ambiguity will ever persist, as the ethnographic moment is part of the broader process of human communication and, thus, it is subject to what Donald Davidson (2001) calls the indeterminacy of interpretation.More than that, however, the traditional propensity of anthropology towards semiotic models of interaction, where conscious meaning is treated as the be-all and end-all of communication, has presently given way to more sophisticated understandings of the fieldwork context. We must find ways of approaching analytically the ethnographic gesture that do not disembody it; that preserve its physicality in a world where what we understand is as much communicated by others as it is understood with others. …
|
2022-12-16T13:43:10.924Z
|
7,397,330 |
{
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"DOI": "10.1248/YAKUSHI.13-00248-1",
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|
A microdose clinical trial may be useful as a safe early-phase exploratory study using doses as low as 100 μg or less for determination of the disposition of a candidate compound in humans in a short period of time. This may increase confidence in candidate compounds, especially those for which it is difficult to predict disposition based on the results of in vitro or preclinical studies. In this study, we examined microdose trials performed in the preclinical stage for two first-in-class compounds with a new mechanism of action. These compounds showed species difference in first pass metabolism in the digestive tract and liver, causing uncertainty in prediction of disposition in humans. For this reason, first-in-human microdose clinical trials were performed. The results showed that the two compounds had effective blood concentrations after oral administration at a dose of 100 mg qd. Administration of an extremely small dose of one (14)C-labeled compound permitted identification of major metabolites. No toxic metabolites were detected. The preclinical toxic dose was determined based on prediction of blood exposure at the estimated maximum clinical dose. For the other candidate compound, the findings of the microdose trial indicated a high bioavailability after oral administration and low hepatic clearance after intravenous administration. These results suggested only a small risk of a change in disposition in patients with hepatic disorder. The data obtained for the two compounds suggest that microdose clinical trials can be useful for improving the process of candidate selection in the preclinical stage.
|
2022-02-13T09:05:34.992Z
|
157,425,960 |
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"ArXiv": null,
"DOI": "10.1177/1024258917701362b",
"MAG": "2618417225",
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},
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}
|
The shadow economy is also based on cash because it makes it easy to avoid taxes and social security contributions. A particular concern of Rogoff is the exploitation of workers without work permits. ‘Dirty money’ is much more prevalent than many realise and should be withdrawn from circulation in a long transitional process to smaller denominations and coins. (ii) He sees cash as a major obstacle to the frictionless functioning of the international payment and financial system, particularly in times in which central banks consider low or even negative interest rates to be necessary. Cash undermines cheap money policy because the hoarding of cash represents an alternative: ‘Paper currency can be thought of as a zero-interest-rate bond’ (p. 4). It thus negates negative interest rates.
|
2022-07-10T03:06:24.705Z
|
658,866 |
{
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"DOI": "10.1109/TFUZZ.2011.2168406",
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|
There is a growing interest in the use of fuzzy intervals in many engineering applications. However, a direct implementation of Zadeh's extension principle, which forms the basis for computing with fuzzy intervals, is still computationally too demanding for practical use. In the case of a continuous function and fuzzy intervals that describe non-interactive variables as inputs, the output is a fuzzy interval as well and can be determined for each α-cut separately. The problem, thus, reduces to finding the endpoints of these α-cuts, which amounts to a number of interwoven optimization problems. In the case of a non-monotone continuous function, however, these optimization problems are non-trivial. In this paper, different optimization algorithms are applied for that purpose: Gradient Descent based on Sequential Quadratic Programming, Simplex-Simulated Annealing, Particle Swarm Optimization, and Particle Swarm Optimization combined with Gradient Descent. In addition, two approaches are followed to determine a suitable number of α-cuts: either a fixed, predetermined number is used, or an initially (very) small number is chosen that is subsequently increased according to a linearity criterion. Both a non-parallel and a parallel implementation are designed. The parallel version is restricted to work with Particle Swarm Optimization and employs communication to optimize its (internal) performance by exploiting the dependence between the various optimization problems. Different configurations are evaluated on a set of benchmark functions in terms of the mean area under the output fuzzy interval and the number of function evaluations. Particle Swarm Optimization combined with Gradient Descent starting from a small number of α-cuts leads to the most accurate fuzzy intervals at the cost of a relatively large number of function evaluations.
|
2022-10-25T10:48:59.730Z
|
32,042,920 |
{
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"DOI": "10.1089/NEU.2005.22.189",
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|
Oxygen free radicals and nitric oxide (NO) participate in the pathogenesis of acute central nervous system (CNS) injury by forming peroxynitrite, which promotes oxidative damage and tyrosine nitration. Neuronal nitration is associated with cell death, but little is known of the characteristics and cell fate of nitrated astrocytes. In this study, we have used a postnatal excitotoxic lesion model (intracortical NMDA injection) and our aims were (i) to evaluate the temporal and spatial pattern of astroglial nitration in correlation with the neuropathological process and the sources of NO; and (ii) to establish, if any, the correlation among astrocyte nitration and other events such as expression of cytoskeletal proteins, antioxidant enzymes, and cell death markers to cope with nitration and/or undergo cell death. Our results show that after postnatal excitotoxic damage two distinct waves of nitration were observed in relation to astrocytes. At 24 h post-lesion, early-nitrated astrocytes were found within the neurodegenerating area, coinciding with the time of maximal cell death. These early-nitrated astrocytes are highly ramified protoplasmic cells, showing diffuse glial fibrillary acidic protein (GFAP) content and expressing inducible NOS. At later time-points, when astrogliosis is morphologically evident, nitrated hypertrophied reactive astrocytes are observed in the penumbra and the neurodegenerated area, displaying increased expression of GFAP and vimentin cytoskeletal proteins and of metallothionein I-II and Cu/Zn superoxide dismutase antioxidant proteins. Moreover, despite revealing activated caspase-3, they do not show TUNEL labeling. In summary, we show that nitrated astrocytes in vivo constitute a subpopulation of highly reactive astrocytes which display high resistance towards oxidative stress induced cell death.
|
2022-12-15T05:02:44.562Z
|
205,882,261 |
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"DOI": "10.1002/hep.25510",
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"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.25510"
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|
Recent research has identified high hepatitis C virus (HCV) prevalence among older U.S. residents who contracted HCV decades ago and may no longer be recognized as high risk. We assessed the cost‐effectiveness of screening 100% of U.S. residents born 1946‐1970 over 5 years (birth‐cohort screening), compared with current risk‐based screening, by projecting costs and outcomes of screening over the remaining lifetime of this birth cohort. A Markov model of the natural history of HCV was developed using data synthesized from surveillance data, published literature, expert opinion, and other secondary sources. We assumed eligible patients were treated with pegylated interferon plus ribavirin, with genotype 1 patients receiving a direct‐acting antiviral in combination. The target population is U.S. residents born 1946‐1970 with no previous HCV diagnosis. Among the estimated 102 million (1.6 million chronically HCV infected) eligible for screening, birth‐cohort screening leads to 84,000 fewer cases of decompensated cirrhosis, 46,000 fewer cases of hepatocellular carcinoma, 10,000 fewer liver transplants, and 78,000 fewer HCV‐related deaths. Birth‐cohort screening leads to higher overall costs than risk‐based screening ($80.4 billion versus $53.7 billion), but yields lower costs related to advanced liver disease ($31.2 billion versus $39.8 billion); birth‐cohort screening produces an incremental cost‐effectiveness ratio (ICER) of $37,700 per quality‐adjusted life year gained versus risk‐based screening. Sensitivity analyses showed that reducing the time horizon during which health and economic consequences are evaluated increases the ICER; similarly, decreasing the treatment rates and efficacy increases the ICER. Model results were relatively insensitive to other inputs. Conclusion: Birth‐cohort screening for HCV is likely to provide important health benefits by reducing lifetime cases of advanced liver disease and HCV‐related deaths and is cost‐effective at conventional willingness‐to‐pay thresholds. (HEPATOLOGY 2012)
|
2022-12-17T13:05:29.093Z
|
24,521,450 |
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"DOI": "10.1109/OFS.2002.1000707",
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}
|
Electrical quantities are now measured by fiber-optic sensors. Usually, these quantities are measured using electro-optic crystals and Faraday rotating materials, separately. Such sensors have a long history and are now utilized in various fields. In this paper, a new proposal to measure electrical quantities using one laser beam, one fiber and, moreover, only one crystal, is described. The quantities to be measured are voltage, current and electric power. This simultaneous measurement can be done using two independent parameters, namely, the ellipticity and the angle of the polarization of one light beam. The proposed design of this simultaneous sensor is given. As the sensing crystal, a quartz crystal is utilized. Since this quartz sensor is less sensitive than lithium niobate or flint glass, this is adequate for application to high-power electronics. The advantageous points of this optical sensor are common with other optical sensors: they have no contact in the measurement, they do not use the power supply at the sensing point and they have no induction noise.
|
2022-12-16T06:33:56.684Z
|
55,729,448 |
{
"externalids": {
"ACL": null,
"ArXiv": "cond-mat/0201580",
"DOI": "10.1103/PhysRevB.66.014204",
"MAG": "2091030866",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
If the number of lattice sites is odd, a quantum particle hopping on a bipartite lattice with random hopping between the two sublattices only is guaranteed to have an eigenstate at zero energy. We show that the localization length of this eigenstate depends strongly on the boundaries of the lattice, and can take values anywhere between the mean free path and infinity. The same dependence on boundary conditions is seen in the conductance of such a lattice if it is connected to electron reservoirs via narrow leads. For any nonzero energy, the dependence on boundary conditions is removed for sufficiently large system sizes.
|
2022-12-22T14:47:51.447Z
|
24,850,682 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1432-1033.1978.TB12373.X",
"MAG": "2039270881",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The effect of pH upon the beta-galactosidase-catalyzed hydrolyses of aryl galactosides is essentially similar for each of the three steps of their hydrolysis. It differs markedly from that on the hydrolysis of galactosyl pyridinium salts; these proceed through a 'non-bottleneck' pathway. While pH increase abolishes the rate of every step of the reaction for aryl galactosides, it favors the first step of hydrolysis of the galactosyl pyridinium salts, which supports the hypothesis that catalysis of these compounds originates largely in non-covalent interactions.
|
2022-12-30T01:22:17.622Z
|
251,611,743 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33448/rsd-v11i10.28943",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://rsdjournal.org/index.php/rsd/article/download/28943/28120"
}
|
O objetivo geral foi analisar dor crônica e qualidade de vida em indivíduos idosos que se autoreferiram portadores de dor crônica na pandemia de COVID-19. Tratou-se de um estudo quantitativo, descritivo, exploratório e transversal, com uma amostragem estratificada composta por 20 indivíduos idosos que autoreferiram portadores de dor crônica e que eram participantes da Universidade Aberta a Maturidade da Universidade Estadual da Paraíba. Foram utilizados como instrumentos de pesquisa: questionários Sociodemográfico; WhoqoL-bref; WhoquoL-old; Escalas Visual Analógica de Dor; Mensuração Geriátrica. Os dados foram analisados pelo programa estatístico SPSS (versão 21.0), por meio de análise de frequências e correlações. Para tal, utilizou-se o Teste t e Correlação Linear de Pearson com nível de significância de p < 0,05. Foram identificados presença de dor crônica moderada na maioria dos idosos, a partir da escala unidimensional de dor (EVA), sendo estudado, também constatado pela Escala de Mensuração Geriátrica (GPM), e a maioria também relatou aumento da intensidade da dor no período de pandemia de COVID-19. As maiores médias observadas pelo uso do Whoquol-bref, se deu para os domínios: psicológico, ambiente, intimidade, funcionamento do sensório e morte e morrer. Quando correlacionados os instrumentos de qualidade de vida com as escalas, na análise bivariada, as médias de qualidade de vida geral correlacionaram-se negativamente com EVA e GPM, havendo relação forte entre essas variáveis, indicando que na medida em que aumenta a dor na pessoa idosa ocorre diminuição na qualidade de vida geral dessas pessoas.
|
2022-08-19T19:10:19.291Z
|
83,044,146 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/adc.58.12.1038",
"MAG": "427458706",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://adc.bmj.com/content/archdischild/58/12/1038.1.full.pdf"
}
|
A colour atlas of clinical genetics , A colour atlas of clinical genetics , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی
|
2022-08-25T09:23:16.357Z
|
149,572,472 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/03906701.2018.1529102",
"MAG": "2897231197",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT The main reference for twentieth century politics is the Nation-state, whose territory-citizens were the unique and only target of norm production. Furthermore, the function of norm production was commitment of public bodies, whose legitimacy – at least in democratic countries – depends on the ‘people’. i.e. the citizens that were the target of the law production itself. An important fact, is that national production of norms slowly shifted from the legislative to the executive power. Too many were the decisions to be made in a brief term, and too fast were people’s emotional reactions, to let this commitment to an impersonal and procedural institution like the legislative power. In a globalized world, things have changed under many aspects. The multiplicity of decisional levels, e.g.: on one side, supranational bodies and entity are more and more frequently assuming this function; furthermore, more and more frequently, national commitments have shifted towards more restricted levels, such as regions or cities. Even the target has turned much more complex: due to more and more massive migration phenomena, all national law makings are nowadays affecting large groups of people, who are not citizens, while citizens are often subjected to other countries’ legislation. Among the main consequences, is that decision-making process have untied from contingent popular reactions and it is possible now to base upon legislative processes, a long-term perspective and a global scale. This paper aims at showing this scenario consequences for innovation processes. Namely, it is possible now to set an environment for innovation by enhancing exchanges of ideas, competences and information is the result of innovation processes, no matter if social or technological. In other words, their work will aim not only at comprehending the process of law-making in the global era, but also proposing models for law-making activities that grant the best environment possible for innovation processes, i.e. free circulation of ideas, science and people.
|
2022-09-04T00:54:27.112Z
|
145,299,161 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/16066351003695631",
"MAG": "2102706709",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In order to determine the independent associations of methamphetamine and heroin use to global psychological distress, symptom patterns and personality disorder, 400 regular users of these drugs were administered the Brief Symptom Inventory. The mean global severity score was 2.39 standard deviations above the population norm, and 24% were classified as cases. After controlling for potential confounders, higher levels of global psychological distress were independently associated with more frequent use of both drug classes. Depression was associated with the frequency of heroin use, but not with methamphetamine use. Phobic anxiety, interpersonal sensitivity and psychoticism were independently related to the frequency of methamphetamine use, but not to heroin use. Neither methamphetamine nor heroin use were independent correlates of a diagnosis of borderline personality disorder or conduct disorder. Whilst higher levels of psychological distress were associated with both methamphetamine and heroin use, symptom patterns were differentially related to the use of these drugs.
|
2022-09-05T08:24:51.593Z
|
54,759,479 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4064/-31-1-151-162",
"MAG": "857613796",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Convexity is the key concept of functional analysis, but apart from some notable exceptions, it has played a relatively minor role in several complex variables theory. The work of Lempert has focused attention on convex domains, and in these two lectures I will present examples involving invariant metrics in complex analysis where convexity, whether realized as in the case of bounded symmetric domains or assumed as in the case of Blp , is essential. Functional analysis brings to problems a variety of developed concepts such as complex extreme points, complex uniform convexity and an approach which is often coordinate and dimension free. I hope to illustrate these points in my lectures. Throughout this article X will denote a Banach space over the complex numbers C, BX will denote the open unit ball in X and BX its closure. We denote by ∆ the open unit disc in C. Our first example relates the maximum modulus theorem of complex analysis with the functional analytic concept of complex extreme point. A point x in X, (‖x‖ = 1), is a complex extreme point (of the unit ball) if ‖x + λy‖ ≤ 1 for all λ ∈ ∆ implies y = 0. The strong maximum modulus theorem, due to Thorp and Whitely in 1965, states the following:
|
2022-09-20T19:19:37.555Z
|
29,428,230 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4103/0974-620X.176093",
"MAG": "2259275206",
"PubMedCentral": "4785705"
},
"license": null,
"status": null,
"url": null
}
|
Optical coherence tomography (OCT), a noninvasive imaging modality that uses low-coherence light to obtain a high-resolution cross-section of biological structures, has evolved dramatically over the years. The Swept-source OCT (SS-OCT) makes use of a single detector with a rapidly tunable laser as a light source. The Casia SS-1000 OCT is a Fourier-domain, SS-OCT designed specifically for imaging the anterior segment. This system achieves high resolution imaging of 10΅m (Axial) and 30΅m (Transverse) and high speed scanning of 30,000 A-scans per second. With a substantial improvement in scan speed, the anterior chamber angles can be imaged 360 degrees in 128 cross sections (each with 512 A-scans) in about 2.4 seconds. We summarize the clinical applications of anterior segment SS-OCT in Glaucoma. Literature search: We searched PubMed and included Medline using the phrases anterior segment optical coherence tomography in ophthalmology, swept-source OCT, use of AS-OCT in glaucoma, use of swept-source AS-OCT in glaucoma, quantitative assessment of angle, filtering bleb in AS-OCT, comparison of AS-OCT with gonioscopy and comparison of AS-OCT with UBM. Search was made for articles dating 1990 to August 2015.
|
2022-12-19T20:29:08.677Z
|
59,155,859 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5376/bt.2015.06.0005",
"MAG": "1885894142",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Plant expression of the entomopathogenic bacteria Bacillus thuringiensis cry gene has reduced the damage created by insect pests in several economically important cultures. The commercialization of Bt plants for insect management has revolutionized agriculture and become a major tool for integrated pest management (IPM) programs. Among the parasitoids of the pest species Spodoptera frugiperda Campoletis flavicincta (Ashmead) is a major parasitoid of larvae. In this context, this study aimed to investigate the interactions of the Bt proteins (from strains of B. thuringiensis , rice and Bt corn) on the parasitoid C. flavicincta and the armyworm S. frugiperda . To evaluate this interaction, S. frugiperda larvae were exposed to four different assays: (T1) without parasitism or exposure to the Bt proteins (control); (T2) exposure only to Bt proteins ( Bt plants or monogenic strains); (T3) exposure only to parasitism by C. flavicincta ; and (T4) exposure to both parasitism and Bt proteins ( Bt plants or monogenic strains). In each treatment, 30 larvae and three replications were included, for a total of 360 larvae. In general, the treatments T4 ( Bt proteins and C. flavicincta ) were more effective in controlling S. frugiperda thus indicating a potential to be used for the pest control in an integrated pest management system.The biological characteristics of C. flavicincta that developed into larvae under the action of Bt thuringiensis differed from parasitoids that emerged from healthy larvae (control). Therefore, the results in this laboratory system may significantly differ from what would be seen in the Field.
|
2022-02-11T16:42:15.272Z
|
51,655,507 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ee.1942.6436225",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
PROPELLER-drive equipment for use in wind-tunnel work, where airplane model testing is involved, presented no unusual problems until the advent of the present national emergency. The emergency stressed the importance of research work in airplane design, necessitating the application of the largest motor drive so far considered where a fixed frequency supply provided the energy source. Tunnels are now in operation or in the process of construction, powered by drives rated up to 40,000 horsepower. The primary condition for all such drives is variable or adjustable speed over at least a 6 to 1 range, with a large number of speed-control points and accurate speed regulation.
|
2022-07-09T06:21:06.690Z
|
153,410,865 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00207546708929770",
"MAG": "1971648983",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
SUMMARY This paper extends existing quantitative methods for the economic evaluation of alternative investment proposals to the arena of decision-making within economies characterized by inflationary trends. The models developed may be used in transactions involving one or several countries each having a differing rate of inflation.
|
2022-10-02T14:51:32.704Z
|
25,327,988 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000087927",
"MAG": "1522172158",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: We recently discovered that APOE ε3/ε4 genotype in men and APOE ε2/ε3 genotype in women are associated with increased risk of death from ischemic stroke (IS). One of the main physiological roles of apolipoprotein E is participation in cholesterol metabolism. A significant association of low serum cholesterol level with increased risk of death from stroke was documented. So, we aimed to establish if an association exists between APOE genotype, serum cholesterol and 1-month mortality in IS. Methods: We studied 666 patients (330 men, 336 women) with a diagnosis of IS. Total serum cholesterol (TC) was measured with the method of Abbott Spectrum (USA). APOE genotyping was performed by PCR-RFLP method. Results:The highest frequency of low serum TC was associated with APOE ε2/ε3 genotype (both in men and in women). Low serum TC was associated with increased mortality rate only in women; this effect was evident only in females not possessing APOE ε2/ε3. Female patients with APOE ε2/ε3 genotype had high 1-month mortality rate independently from serum TC. In multiple regression analyses APOE ε3/ε4 genotype in men and APOE ε2/ε3 genotype in women predicted risk of death independently from serum TC and also from other potential pre- and post-stroke prognostic factors. Conclusion:APOE ε3/ε4 genotype in men and APOE ε2/ε3 in women are associated with increased 30-day mortality in stroke. This effect seems be independent from serum cholesterol.
|
2022-12-03T18:15:09.731Z
|
254,356,481 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/electronics11233951",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2079-9292/11/23/3951/pdf?version=1669769311"
}
|
Based on the good performance of deep reinforcement learning (DRL) in policy optimization, a stereoscopic projection policy optimization method is proposed, which combines the simulation experiment method with the DRL method. On the basis of policy optimization research, a deep learning framework is selected according to the research problems, and a DRL stereoscopic project policy model based on the asynchronous advantage actor–critic (A3C) algorithm, which uses two groups of neural networks, is constructed. The optimized stereoscopic projection policy is obtained by the interactive learning between the DRL model and the simulation. The effectiveness of the cooperative optimization policy between the DRL and the simulation experiment is verified.
|
2022-12-07T22:54:29.894Z
|
22,167,832 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/EM.2850260304",
"MAG": "1978078542",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To assess the potential effect of maternal environments on human embryonic/fetal somatic mutation, we measured the frequencies of hypoxanthine‐guanine phosphoribosyltransferase (HPRT, hprt gene), mutant T lymphocytes (Mf), and glycophorin A (GPA) variant erythrocytes (Vf) of both allele‐loss (ø/N) and allele‐loss‐and‐duplication (N/N) phenotypes in umbilical cord blood. The mean hprt Mf (1.40 ± 1.11 × 10−6, N = 66) and GPA Vf (ø/N 4.0 ± 2.2 × 10−6, N = 114; N/N 2.7 ± 2.0 × 10−6, N = 91) were significantly lower than those previously reported for adult populations. In addition, the hprt Mf was significantly higher than that of a published study of newborn cord blood samples from a geographically distant population (0.64 ± 0.41 × 10−6, N = 45, P < 0.01; t test, P < 0.01, Mann‐Whitney U test). An examination of the demographic data from these two populations led to the sampling of 10 additional newborns specifically matched to the published study for maternal socioeconomic status. The hprt Mf (0.70 ± 0.49 × 10−6) of this selected population was consistent with the published report and significantly lower than that of our initial population (P < 0.03, t test; P < 0.01, Mann‐Whitney U test). These results indicate that there is an environmental effect related to maternal socioeconomic status on the frequency of embryonic/fetal somatic mutations. Molecular analyses of hprt mutants from this cohort with elevated Mf revealed a significant decrease in the relative contribution of gross structural mutations to the overall Mf (25 of 38, 66% vs. 34 of 41, 83%, P = 0.024, x2 test), suggesting that the higher Mf resulted from an elevated level of “point” mutations. No individual maternal demographic or environmental factor was identified as contributing more significantly than other any factor to the observed variability in hprt Mf or GPA Vf. © 1995 Wiley‐Liss, Inc.
|
2022-12-21T01:20:10.236Z
|
236,568,856 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/CASP.2535",
"MAG": "3163897498",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Passing is the research of oneself by trying to look and to be seen as a member of a social group by assuming its features. Individuals performing this process are willing to undergo several physical and behavioural changes to achieve this aspiration. Passing generally occurs among members of minority groups suffering discrimination who want to diminish the psycho-social discomfort of their experience. Exam-ples of passing are the attempts by ethnic minorities to whiten their skin, or the efforts of transgender people to look as much as possible, in the eyes of others, like the gender with which they identify. This paper aims to discuss aspects related to trans people's pursuit of passing, taking the Theory of Performativity of Gender and the Cultural Semiotic Psychology as its theoretical basis. This is a theoretical-reflexive study that will debate the topic based on studies of this topic in Brazilian society.
|
2022-12-23T02:05:05.152Z
|
161,645,104 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22201/CIALC.24486914E.2011.53.56447",
"MAG": "1612039228",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
La tesis central de este documento gira en torno a esclarecer como los asentamientos ilegales, denominados hoy por las autoridades locales como Asentamientos Humanos de Desarrollo Incompleto (Decreto 0419 del 24 de mayo de 1999), son expresiones de tres procesos complejos relacionados: por un lado, son manifestaciones de las contradicciones de las fuerzas del mercado y de las fuerzas del Estado; por otro, son resultado de luchas sociales urbanas lideradas por grupos y comunidades ante el Estado. Y en este sentido, las comunidades exigen del Estado, su principal interlocutor a traves de procesos de resolucion como la negociacion, respuestas que les beneficien y les garanticen la solucion a sus problemas de exclusion y marginacion.
|
2022-02-08T22:08:09.467Z
|
118,126,974 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4064/CM-83-1-125-136",
"MAG": "1030014057",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Let L be a Banach lattice of real-valued measurable functions on a σ-finite measure space and T = {Tt : t > 0} be a strongly continuous semigroup of positive linear operators on the Banach lattice L. Under some suitable norm conditions on L we prove a general differentiation theorem for superadditive processes in L with respect to the semigroup T . Introduction. In this paper a differentiation theorem is proved for superadditive processes in a Banach lattice of functions having an absolutely continuous norm. Let (Ω,Σ, μ) be a σ-finite measure space and L a vector lattice of realvalued measurable functions on (Ω,Σ, μ) under pointwise operations. Thus we understand that if f ∈ L then the function f(ω) = max{f(ω), 0} is also in L, and two functions f and g in L are not distinguished provided that f(ω) = g(ω) for almost all ω ∈ Ω. We let |f |(ω) = max{f(ω),−f(ω)}. Hereafter all statements and relations are assumed to hold modulo sets of measure zero. We further assume that L becomes a Banach space under the norm ‖ · ‖, and suppose the following properties: (I) If f, g ∈ L and |f |(ω) ≤ |g|(ω) a.e. on Ω then ‖f‖ ≤ ‖g‖. (II) If g is a real-valued measurable function on Ω such that |g|(ω) ≤ |f |(ω) a.e. on Ω for some f ∈ L then g ∈ L. (III) If En ∈ Σ, En ⊃ En+1 for each n ≥ 1 and ⋂∞ n=1 En = ∅ then for any f ∈ L we have lim n→∞ ‖f · χEn‖ = 0, where χEn denotes the characteristic function of En. 2000 Mathematics Subject Classification: Primary 47A35.
|
2022-06-29T08:48:46.792Z
|
119,541,219 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1121/1.4786275",
"MAG": "1979693548",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An articulatory study of the scope of prosodic boundary effects across boundaries of varying strengths is presented. Sentences in each of three prosodic conditions contain the following string: C1VC2VC3♯VC4VC5VC6, where C is an alveolar consonant, V is a vowel, and ♯ is a prosodic boundary. The boundaries are of three degrees of strength. Using articulator movement‐tracking data (EMA) for the tongue tip articulator, consonant constriction formation and release duration, acceleration duration, and spatial magnitude are measured. Leftward and rightward temporal effects of the boundary on the consonants are investigated. Based on earlier studies (e.g. Cambier‐Langeveld, Linguistics in the Netherlands, 13–24, 1997; Shattuck‐Hufnagel and Turk, Proceedings 16th International congress on Acoustics and 135th Meeting Acoustical Society of America, 1235–1236, 1998; Berkovits, J. of Phonetics 21, 479–489, 1993) and predictions of the prosodic gestural model (Byrd and Saltzman, J. of Phonetics, 31, 149–180, 2003), it...
|
2022-02-09T22:37:20.965Z
|
45,814,394 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ol801107j",
"MAG": "1967864427",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
N-Allylhydrazones are reported to undergo an elaborate [3,3]-sigmatropic shift/N2 extrusion sequence. Both concerted and radical cation pathways for the [3,3]-sigmatropic shift of several N-allylhydrazones were investigated using B3LYP/6-31+G(d,p) calculations. It was discovered that, assuming facile formation of the N-allylhydrazone radical cation, the rearrangement takes place through a series of low barrier steps energetically preferred to the concerted alternative available to neutral N-allylhydrazones. Subsequent N2 extrusions forming corresponding homoallyl radicals were found to be extremely facile.
|
2022-09-06T04:18:00.603Z
|
154,845,505 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3905/jii.2014.5.1.146",
"MAG": "2128040657",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A new category of exchange-traded funds, which can arguably be referred to as “smart beta ETFs,” has lately issued a meaningful challenge to traditional, market-value-oriented ETFs. Although the concept seems new, a review of the relevant academic literature shows that most of these new ETFs find their roots in traditional ETFs. After having divided smart beta ETFs into three distinct categories, a thorough review shows that their share of the overall ETF market is rapidly expanding. In particular, factor and fundamental smart beta ETFs have established themselves as the dominant duo relative to low-volatility ETFs. But in terms of risk-adjusted performance, this study shows that investors in smart beta ETFs have, on average, not been appropriately compensated for the risks they have taken in comparison to investors who put their money into more traditional, cap-weighted ETFs.
|
2022-09-15T04:09:11.572Z
|
18,799,611 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15226/2374-6858/1/1/00105",
"MAG": "2371162081",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://symbiosisonlinepublishing.com/neurology/neurology05.pdf"
}
|
INTRODUCTION
To determine the clinical significance of elevation of Troponin-I [cTn-I] during prolonged status epilepticus [pSE] SE is known to be accompanied by an increase in sympathetic outflow. Elevation of cTn-I has been linked to myocardial stress. We hypothesize that in patients with risk factors for coronary artery disease[CAD], pSE may lead to myocardial stress and an elevation of cTn-I.
METHODS
This is a retrospective study of patients over the age of 18 years who were presented to Virginia Commonwealth University with SE between 2005 and 2010. Data was evaluated using the 30-minute definition for SE and 30 day mortality. Risk factors for CAD and cTn-I levels within the first 24 hours of diagnosis of pSE were analyzed.
KEY FINDINGS
There were a total of 435 patients with a confirmed diagnosis of pSE, of which 266 had cTn-I concentrations reported. Statistical analysis showed a significant association between CAD risk factors and cTn-I elevation (χ2 =12.87, p-value <0.01), with Crude Odds Ratio of 4.7. In patients with a CAD risk factor, an elevation of cTn-I is associated with a significantly increased risk of mortality, with an Odds ratio of 8.0, (χ2 =40, [95% CI 4.1-15.9] p-value < 0.01). Mortality was higher in those with an elevation of cTn-I [54.65%] as opposed to those who did not have an elevation [15.08%], irrespective of CAD risk factors. OR=6.7, (χ2 =45, [95% CI=3.7-12.2] p-value < 0.01).
CONCLUSIONS
In patients with pSE values, elevated cTn-I values are seen four to five time more often in those with CAD risk factors, as opposed to those without the risks. An elevation of cTn-I in this subgroup of patients with CAD risk factors was associated with an eight to nine fold increase in their 30 day mortality as compared to patients with pSE, who did not have an elevation of cTn-I.
|
2022-12-11T06:43:41.197Z
|
42,781,345 |
{
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"ArXiv": null,
"DOI": "10.2169/INTERNALMEDICINE.35.587",
"MAG": "1979018049",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A 20-year-old man developed fever and urinary abnormalities with positive antinuclear antibody (ANA) two months after the start of ethosuximide. A renal biopsy showed mild mesangial cell proliferation and cellular crescents predominantly occupying a vascular pole in 7 out of 80 (8.8%) glomeruli. In the arteriole, mainly in close proximity to the glomerulus, proliferation of smooth muscle cells and luminal narrowing were observed. Discontinuation of ethosuximide led to the disappearance of fever, ANA and urinary abnormalities. These findings are strongly suggestive of a causal relationship between ethosuximide and a lupus-like syndrome with peculiar renal involvement.
|
2022-12-25T23:03:15.559Z
|
154,482,645 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0010414006291833",
"MAG": "2161392827",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Levels of both political and social trust tend to play a crucial role in democracies. Yet we have little understanding of the ways in which trust operates in nondemocratic societies. This article finds that levels of political confidence are linked to generalized trust in both democratic and nondemocratic states. In democracies, then, levels of generalized trust may reinforce existing democratic institutions. In nondemocracies, however, generalized trust may be linked to support for authoritarian patterns of rule. This article argues that although generalized trust serves democracy in democratic settings, it is not linked to democratic forms of political and social engagement in the less democratic states of the Arab world.
|
2023-01-01T18:16:01.961Z
|
201,792,846 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5325/transportationj.59.2.iiia",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Almost a quarter of a century has passed since a major business history journal has devoted a special issue to East Asia. In his introduction to that issue, Yen-p’ing Hao, one of the pioneers of Chinese business history, lamented the paucity of historical work on Chinese business compared to studies of China’s political revolution.1 There is no question that the latest stage in the Chinese revolution has stimulated a new interest in the legacy of industrial and commercial development in China, and not simply because China is becoming an economic power whose business past takes on new relevance for a business present. Reform has created new opportunities for the historian, as well as for the entrepreneur. The opening of Chinese archives and the publication of company records compiled by Chinese researchers have resulted in a renaissance in empirically based Chinese business history.2 Moreover, the vigor with which China’s industrial and commercial economy has responded to both internal and external opportunities has stimulated a reevaluation of the paradigms by which Chinese business has, until recently, been understood.
|
2022-07-19T13:33:35.395Z
|
24,360,939 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/BIP.360290816",
"MAG": "2058266603",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The sieving of rod‐shaped viruses during agarose gel electrophoresis is quantitatively analyzed here with a previously proposed model [G. A. Griess et al. (1989) Biopolymers, 28, 1475–1484] that has one radius (PE) of the effective pore at each concentration of gel. By use of this model and an internal spherical size standard, a plot of electrophoretic mobility vs agarose percentage is converted to a plot of the radius of the effective sphere (effective radius) vs PE. Experimentally, when the concentration of the rod‐shaped bacteriophage, fd, is progressively increased, eventually the electrophoretic mobility of fd becomes dependent on its concentration. The concentration of fd at which this occurs decreases as the agarose concentration decreases. After avoiding this dependence on the concentration of sample, the effective radius of rod‐shaped particles, including bacteriophage fd, length variants of fd, and length variants of tobacco mosaic virus, is found to increase as PE increases until a plateau of approximately constant maximum effective radius is reached at P cE . In the region of this plateau, the effective sphere's measure that best approximates that of the rod is surface area. However, significant disagreement with the data exists for surface area; the maximum effective radius for fd varies as (length)0.69. For fd and its length variants, the value of 2·P cE /length increases from 0.21 to 0.86 as the length decreases from 2808 to 367 nm. The dependence of effective radius on PE and the proximity of 2·P cE to the length of the rod are explained by (a) random orientation of rods at PE values in the region of the plateau, and (b) increasingly preferential end‐first orientation (reptation) of the rod as PE decreases below P cE . This hypothesis of reptation is supported by a significant dependence of electrophoretic mobility on electrical potential gradient for a PE below, but not above, P cE . The dependence of 2·P cE /length on length is not rigorously understood, but is qualitatively explained by flexibility of the rods. This apparent flexibility has thus far prevented determination of a rod's axial ratio from quantitation of sieving during agarose gel electrophoresis. The electrical potential dependence of electrophoretic mobility is determined here by a procedure of two‐dimensional agarose gel electrophoresis. This procedure is also useful for detecting rod‐shaped particles in heterogeneous mixtures of predominantly spherical particles.
|
2022-11-26T07:29:08.168Z
|
12,777,008 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15585/mmwr.mm6436a8",
"MAG": null,
"PubMedCentral": "4604800"
},
"license": null,
"status": "GREEN",
"url": "http://pdfs.semanticscholar.org/82d5/7f25521d98a987a697acda75c05db018436a.pdf"
}
|
The tables listed in this report on pages 970–982 summarize finalized data, as of June 30, 2013, from the National Notifiable Diseases Surveillance System (NNDSS) for 2012. These data will be published in more detail in the Summary of Notifiable Diseases — United States, 2012 (1). Because no cases were reported in the United States during 2012, the following diseases do not appear in these early release tables: anthrax; eastern equine encephalitis virus disease, nonneuroinvasive; poliomyelitis, paralytic; poliovirus infection, nonparalytic; Powassan virus nonneuroinvasive disease; severe acute respiratory syndrome–associated coronavirus disease (SARSCoV); smallpox; western equine encephalitis virus disease, neuroinvasive and nonneuroinvasive; yellow fever; and viral hemorrhagic fevers. Policies for reporting NNDSS data to CDC can vary by disease or reporting jurisdiction depending on case status classification (i.e., confirmed, probable, or suspected). The publication criteria used for the 2012 finalized tables are listed in the “Print Criteria” column of the NNDSS event code list, available at http://wwwn.cdc.gov/nndss/document/ nndss_event_code_list_2012.pdf. In addition, only cases Notice to Readers
|
2022-12-09T23:30:20.735Z
|
84,364,094 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1089/JIR.1992.12.199",
"MAG": "1999456983",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Monocytes, recovered from human peripheral blood by counter-current centrifugal elutriation (CCE), suppressed baseline natural killer (NK) cell cytotoxicity (NKCC) and rendered NK cells resistant to activation of cytotoxicity by human recombinant interferon-α (IFN-α) by a cell contact-dependent mechanism. Monocyte-induced suppression of resting and IFN-activated NK cells was abrogated by the biogenic amines histamine [via H2-type receptors (H2R)] and serotonin [via 5-HT1A-type receptors (5-HT1AR)]. Our data are suggestive of a monocyte/NK cell interaction that is subject to regulation by biogenic amines.
|
2022-12-10T00:10:31.601Z
|
108,885,210 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1115/DETC2007-34499",
"MAG": "1972651113",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Modular robotic systems have become popular in recent years due to the ease of reconfigurability to satisfy varying task requirements. Due to the nonlinear nature of the actuator performance parameters, it is often difficult to map component specifications to the overall system performance making it cumbersome to use these parameters to design the system. Specifying system requirements based on task specifications, on the other hand, provides greater insight into how the system must perform in order to complete a given task and the resources required to achieve this performance. In this paper, we present a method for optimal design of modular robotic manipulators using a finite set of actuators to execute various tasks. Three different tasks — material removal, welding and a pick-and-place operation — which have different requirements in terms of the force, speed, precision and energy required to perform them, are considered. A set of five actuators is used to form different serial robotic manipulator configurations whose ability to accomplish the task is then evaluated using various performance metrics. A sequential filtering method is used to eliminate infeasible manipulator configurations and the remaining feasible set of manipulator configurations are then optimized using the weighted sum and compromise multiobjective optimization methods to determine a Pareto optimal manipulator configuration to accomplish each of the three tasks individually, in addition to a fourth manipulator configuration that is capable of accomplishing all the three tasks.Copyright © 2007 by ASME
|
2022-06-18T12:29:59.676Z
|
115,074,557 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22067/JPP.V25I1.9594",
"MAG": "2485834842",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract
In order to evaluate the effect of tillage number and metribuzin herbicide doses on weeds structure of potato, an experiment was conducted as the factorial in randomized complete block design with three replications in 2009 in the Sarab region of East Azarbaijan Province. The first factor was tillage number with a single moldboard plowing at autumn and double plowing (fall and spring moldboard plowing) and the second factor was different doses of metribuzin herbicide (Sencor) at three levels, 0 (control), 0.5 and 1 kg ai ha-1. The results showed that double plowing compared with single autumn tillage reduced weed density by 65.3% at potato emergence stage. Metribuzin application compared with control decreased weeds density 40 to 58 percent and their dry weight 38 to 60 percent. Highest tuber yield (36/29 t ha-1) was achieved in single autumn tillage treatment that was 14/66 percent over the potato tubers yield in the double plow.
Key words: Integrated Weed management, Metribuzin, Potato, Tillage number, Weed structure
|
2022-02-10T01:03:04.554Z
|
71,113,895 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/JAMA.1935.02760010008002",
"MAG": "1967732633",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper deals only with the acute perforations that demand immediate operation. It does not concern those cases of perforation of marginal ulcers causing gastrocolic fistulas, chronic abscesses posterior to the stomach, intermittent leakage with blockage to which attention was called by Lund 1 in 1905, or even the forme fruste types of perforated ulcers recently described by Singer. 2 The deductions reached are largely based on personal experience in the treatment of forty-one such cases. This experience has been greatly influenced, however, by numerous visits to other hospitals, conversation with other surgeons, and a careful review of the literature. Of course it is generally conceded, even by the most radical adherents of the nonsurgically inclined of medical men, that surgery offers the best hope of recovery. Therefore this discussion will be confined to surgical intervention in this condition, as considered under the following three headings: 1. Drainage after closure
|
2022-02-11T11:06:45.434Z
|
251,938,524 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/15257401221119969",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
With the COVID-19 pandemic necessitating the adoption of telepractice for providing speech and language therapy services, this study investigated the factors affecting the perceptions and the implementation of telepractice for school-age children by speech language speech-language pathologists (SLPs) in the Philippines. Sixty-four SLPs completed a 36-item online survey assessing the adoption of telepractice, implementation concerns, student candidacy, continuous training in telepractice, and the SLPs’ demographics. The SLPs reported that they quickly adopted telepractice in their services for school-age students at the start of the pandemic. Multiple linear regression analyses revealed that SLPs’ perceptions of the effectiveness of telepractice were significantly affected by implementation difficulties while SLPs’ future use of telepractice was significantly predicted by training and resource availability. These results suggest that professional training and other therapeutic resources are needed to alleviate SLPs’ concerns about difficulties in implementing and continuing use of telepractice.
|
2022-09-21T13:18:38.517Z
|
80,855,740 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18689/MJS-1000104",
"MAG": "2904616446",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Cancers of the oral cavity present in a variable way but are often associated with persisting swelling or ulceration within the oral cavity. In the Indian subcontinent, oropharyngeal cancer is the common malignant tumour accounting for 40% of all cancers. Aims and Objectives: To study the principles and outcomes of flaps used in reconstruction of carcinoma of cheek in view of maintaining oral competence, facilitate swallowing, preserving speech, prevent aspiration and to achieve better cosmesis. Materials and Methods: A prospective, open label, randomized, hospital based, single centered study was conducted among 60 subjects attending Surgical Oncology OPD, K.R. Hospital attached to Mysore Medical College And Research Institute, Mysore meeting the inclusion and exclusion criteria over a period of 24 months from January 2016 to December 2017. All patients who present with symptoms and signs of Carcinoma cheek, and confirmed by Edge Biopsy, FNAC of Nodes, X-Ray mandible and ortho pantamogram were included in the study. Patients suffering from Ca lip, Ca tongue, Ca oropharynx and Ca maxilla are excluded. Descriptive statistics, Chi-square test, Multivariate Cox regression analysis were used to analyse the results. Results: The mean age group of the study subjects was 52.63+7.48 (34-86) years. The gender distribution showed 52(86.67%) females as compared to 8(13.33%) males. Maximum number of 29(48.33%) patients presents in Stage-IV while minimum number of 8(13.33%) patients presented in Stage-II. 13(21.67%) and 10(16.67%) patients presented in Stage-III and Stage-I respectively. 15(25%) and 17(28.33%) of patients underwent reconstruction with the Pectoralis major myocutaneous flap(PMMC) & PMMC+DP Flaps respectively. 6(10%) patients underwent tongue flap while 5(8.33%) patients underwent forehead flap (p <0.0001). 4(6.67%) and 1(1.67%) patients underwent Deltopectoral (DP) and tongue +DP flap respectively. Postoperative complications like infection and necrosis occurred in 3(5%) and 1(1.67%) cases respectively, while oro-cutaneous fistula occurred in 1(1.67%) cases and 1(1.67%) case showed recurrence. Conclusion: Patients subjected to reconstruction of cheek defect with PMMC & PMMC + DP flap shows better results in terms of oral competence, speech, swallowing & cosmetic appearance when compared to other flaps.
|
2022-09-16T09:17:55.066Z
|
238,022,691 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18510/HSSR.2021.9415",
"MAG": "3186913123",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Purpose: The paper explores how livestock reveals the warming climatic variations particularly in farming and poultry sub-sectors of agriculture. The rising average temperature of the region has been a challenge during the last two decades which has created many complications and health problems in animals as stress, low reproduction, its consequence as draught, adverse effects on milk and meat production. More consumption of water increases the cost of livestock products. It has altered the temperature of the sea and rivers, emerges the negative effects on the species and creatures of water.
Methodology: To conduct the empirical study on this economic issue the data has been assumed from 1980 to 2014 due to constraints of statistics. Auto-Regressive Distributive Lag model to cointegration (ARDL) was applied on the time series data and the other econometric tests as Error Correction Mechanism, Cumulative sum of Recursive Residual CUSUM and CUSUM sum of Square Test, Bound Test and Diagnostic tests were operated to conclude the results of the research study.
Main findings: The finding of the study is that CO2emission from electricity, gases fuel consumption, and urban population growth raised the average temperature of the region which is discouraging the livestock. Production and increasing the costs of livestock output.
Application of the study: The study is the most appropriate and applicable for this subcontinent especially for Pakistan.
Originality and novelty of the study: The research study contributes to the agricultural economics literature with advanced information. It suggests the government utilize the planet Badar-1 climatic information and more advanced technology about temperature to formulate comprehensive policies to combat the climatic and environmental changes and more resources are allocated so that international standard of production of livestock can be achieved.
|
2022-12-10T11:22:32.535Z
|
23,822,022 |
{
"externalids": {
"ACL": null,
"ArXiv": "1207.4521",
"DOI": "10.1103/PhysRevLett.110.114503",
"MAG": "2065224749",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We employ detailed numerical simulations to probe the mechanism of flow reversals in two-dimensional turbulent convection. We show that the reversals occur via a vortex reconnection of two attracting corner rolls having the same sign of vorticity, thus leading to major restructuring of the flow. Large fluctuations in heat transport are observed during the reversal due to the flow reconfiguration. The flow configurations during the reversals have been analyzed quantitatively using large-scale modes. Using these tools, we also show why flow reversals occur for a restricted range of Rayleigh and Prandtl numbers.
|
2022-12-12T13:55:50.346Z
|
44,804,394 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1074/mcp.O113.032748",
"MAG": "2108390244",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The covalent attachment of methyl groups to the side-chain of arginine residues is known to play essential roles in regulation of transcription, protein function, and RNA metabolism. The specific N-methylation of arginine residues is catalyzed by a small family of gene products known as protein arginine methyltransferases; however, very little is known about which arginine residues become methylated on target substrates. Here we describe a proteomics methodology that combines single-step immunoenrichment of methylated peptides with high-resolution mass spectrometry to identify endogenous arginine mono-methylation (MMA) sites. We thereby identify 1027 site-specific MMA sites on 494 human proteins, discovering numerous novel mono-methylation targets and confirming the majority of currently known MMA substrates. Nuclear RNA-binding proteins involved in RNA processing, RNA localization, transcription, and chromatin remodeling are predominantly found modified with MMA. Despite this, MMA sites prominently are located outside RNA-binding domains as compared with the proteome-wide distribution of arginine residues. Quantification of arginine methylation in cells treated with Actinomycin D uncovers strong site-specific regulation of MMA sites during transcriptional arrest. Interestingly, several MMA sites are down-regulated after a few hours of transcriptional arrest. In contrast, the corresponding di-methylation or protein expression levels are not altered, confirming that MMA sites contain regulated functions on their own. Collectively, we present a site-specific MMA data set in human cells and demonstrate for the first time that MMA is a dynamic post-translational modification regulated during transcriptional arrest by a hitherto uncharacterized arginine demethylase.
|
2022-12-17T05:13:07.097Z
|
196,546,673 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/annrheumdis-2019-eular.6986",
"MAG": "2952728142",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://ard.bmj.com/content/annrheumdis/78/Suppl_2/1635.1.full.pdf"
}
|
Background Bone involvement in rheumatoid arthritis is characterized by focal articular bone loss around inflamed small joints of the hands.[1] Therefore, precise quantification of hand bone loss may predict the severity and the progression of the disease. Objectives The aim of this study is to find a correlation between wrist bone mineral density (BMD) and sonographic wrist synovitis in patients with rheumatoid arthritis (RA). Methods RA patients were examined by bone mineral density (BMD) measurement of the wrist using dual-energy X-ray absorptiometry (DXA) according to standard protocols for positionning and analysis (area measured at a level of 33%). Patients were diagnosed as having osteoporosis when the minimum T-score measured was less than -2.5 SD, osteopenia if T-score between -2,5 and –1 SD [2]. Ultrasound of the wrist was done by an operator with experience in musculoskeletal ultrasound with an esaote My lab60 machine. The wrist joint (inferior radio-ulnar joint, medio-carpal joint and ulnar recessus) was assessed on dorsal side in Gray and Power Doppler (PDUS) scales. Semi-quantitative score was used to sum the synovitis score.[3] Statistical analysis comparing synovitis and BMD was performed using Kruskal Wallis Test, a non-parametric test (Mann–Whitney U-test) and chi-square, as appropriate. Results The study included 24 RA patients with female predominance (sex ratio=0,3). The mean age was 59.3 [47-71] years-old. The duration of the disease was 10.2 years [0,83 -23] and the body mass index was 27.3 (18.97-36.98) kg/m2. RA was erosive in 75% of cases. Sixty-seven percent of patients received calcium supplementation. All women experienced already menopause. Most of them (75%) were on corticosteroids at the average dose of 5 mg [5-15], two of whom were not supplemented. Only one quarter of patients had physical activity. BMD showed that 45% of patients suffered from osteoporosis and 25% are osteopenic with a mean T-score of -1.92 [-4.3; 1.4] and mean bone mass of 0.475 g/cm2[0.239,0.712]. Forty-eight wrists were assessed by ultrasound. Medio-carpal joint was the most affected in Gray scale and Doppler. Fifty-eight percent of patients had moderate to severe synovitis when combined scoring was used. Twenty nine percent of patients (29,1%) had grade 3 at Gray Scale and 25% had Doppler scale grade 3. The wrist BMD (T-score) in RA with high disease activity was lower than those with moderate or low disease activity (-2.21 vs -2.05 and -2,21 vs 0.6 respectively; p=0,431). There was no correlation between BMD of the wrist and the disease duration as well as the activity of the disease DAS28 VS (respectively p = 0.4, p = 0.58).The percentages of wrist synovitis in osteoporosis group were significantly higher than in osteopenia group (81.8% vs. 66%, p=0,03).Moroever, Gray scale grade 3 synovitis in osteoportic patients was higher than osteopenic patients (62,5% vs 25% respectively,p=0,041). Results also showed a correlation between BMD and doppler mode grade 3 (83%vs 16,7 respectively,p=0,014). Conclusion This study shows a highly significant correlation between the BMD of the wrist and synovitis. Local inflammation of the wrist is an important factor of local bone loss that should be acted upon in order to avoid fractures, especially Colles’ fracture. References [1] Hansen M,et al. Bone loss in rheumatoid arthritis.. Scand J Rheumatol. 1996;25:367–376 [2] World Health Organization (2004) WHO scientific group on the assessment of osteoporosis at primary health care level.p. 5–7. [3] D’Agostino M L, et al.Scoring ultrasound synovitis in rheumatoid arthritis : a EULAR-OMERACT ultrasound taskforce—Part 1: definition and development of a standardised, consensus-based scoring system.RMD Open; 2017;000428. Disclosure of Interests None declared
|
2022-12-19T09:58:25.236Z
|
11,182,448 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5754/hge09582",
"MAG": "152364200",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND/AIMS
Few studies on Cytomegalovirus (CMV) infection in adult-to-adult living donor liver transplantation (LDLT) have been reported. The aim of this study was to analyze the incidence, risk factors and management of CMV infection after LDLT.
METHODOLOGY
Retrospective analysis was performed with 72 consecutive adult cases.
RESULTS
CMV antigenemia was demonstrated in 31 (43.1%) patients and 9 patients (12.5%) manifested fever. Twelve patients were treated with intravenous ganciclovir (GCV) injection. There was improvement in 10 patients; foscanet concomitant with CMV-IG was administered in one patient who had an adverse effect resulting in improvement and another one resulted in death from sepsis. Twelve patients were given oral valganciclovir (VGCV) and all showed improvement. ABO incompatible transplantation was associated with CMV infection after LDLT in both the univariate (p=0.005) and multivariate analyses (p=0.04). After discharge 12 out of 63 patients (19%) suffered from CMV infection and all of them were taking steroid.
CONCLUSIONS
ABO incompatible transplantation was demonstrated as a risk factor for CMV infection during hospitalization. After discharge immunosuppressive status seemed to be more essential as a predictor for CMV infection. Routine examination to detect CMV antigenemia is needed especially in patients with potentially over-immunosuppressive conditions in out-patient clinics.
|
2022-12-20T10:10:59.737Z
|
31,722,861 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1126/SCIENCE.1072359",
"MAG": "2089369878",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We used Arabidopsis thaliana mutants to examine how a photosynthetic regulatory process, the qE-type or ΔpH-dependent nonphotochemical quenching, hereafter named feedback de-excitation, influences plant fitness in different light environments. We show that the feedback de-excitation is important for plant fitness in the field and in fluctuating light in a controlled environment but that it does not affect plant performance under constant light conditions. Our findings demonstrate that the feedback de-excitation confers a strong fitness advantage under field conditions and suggest that this advantage is due to the increase in plant tolerance to variation in light intensity rather than tolerance to high-intensity light itself.
|
2022-12-25T23:07:00.217Z
|
213,223,184 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26905/jmdk.v7i2.3023",
"MAG": "2998365288",
"PubMedCentral": null
},
"license": "CCBYSA",
"status": "GOLD",
"url": "https://jurnal.unmer.ac.id/index.php/jmdk/article/download/3023/pdf"
}
|
This study aims to know the determinants of MSME performance in Banyuwangi. This research is an explanatory research. Samples determining in this study use a purposive sampling technique. Primary data in this study is collected by survey techniques for 51 MSME players in Banyuwangi. This study uses SEM-PLS analysis. The exogenous variables are Market Orientation (MO), Learning Orientation (LO), Innovation (IN), and Technology Orientation (TO). The endogenous variable is the performance of MSMEs. The results of this study show that MO, LO, and TO variables are not the factors that can improve the performance of MSMEs. In other word, the results show that MSME players have not considered MO, LO, and TO in their operations. The results of this study also show that the IN variable are able to improve the performance of MSMEs in Banyuwangi. This means that the higher the innovation carried out by MSME players, the more better the performance of MSMEs in Banyuwangi. https://doi.org/10.26905/jmdk.v7i2.3023
|
2022-02-25T00:20:37.015Z
|
147,400,649 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.5553/FenR/.000024",
"MAG": "2339808093",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
1. Op donderdag 12 en vrijdag 13 november 2015 vond het eerste internationale besloten expertenseminarie van RETHINKIN. plaats te Gent en Kortrijk. Dit seminarie is het initiatief van de Wetenschappelijke Onderzoeks Groep (WOG) RETHINKIN. (Rethinking legal kinship studies in the Low Countries). Deze WOG is het resultaat van de samenwerking tussen enerzijds de Vlaamse Vereniging voor Familie & Recht (V.Fam.) en anderzijds de Nederlandse Alliantie Familie & Recht. Het doel van RETHINKIN. is het herdefiniëren van het familierecht in de Lage Landen (www.rethinkin.eu). 2. Op het seminarie debatteerden internationale experten gedurende twee dagen over twee thema’s: de vergoeding van huishoudelijke inspanningen in relaties enerzijds en de zorg voor ouderen anderzijds. Deze topics werden op de eerste dag geanalyseerd vanuit economisch standpunt. Hierna wordt enkel ingegaan op de tweede dag van het seminarie, waarop beide thema’s in juridisch en historisch perspectief werden geplaatst.
|
2022-02-09T05:26:55.125Z
|
118,800,133 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18860/CA.V3I2.2582",
"MAG": "1535711670",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ruang Banach merupakan suatu konsep penting dalam analisis fungsional. Pada tahun 1992, seorang ahli matematika berasal dari Polandia membuktikan teorema yang menyatakan ketunggalan titik tetap. Teorema tersebut disebut juga dengan teorema titik tetap Banach. Teorema titik tetap Banach (teorema kontraksi) merupakan teorema ketunggalan dari suatu titik tetap pada suatu pemetaan yang disebut kontraksi dari ruang metrik lengkap ke dalam dirinya sendiri. Pengertian ruang Banach sendiri adalah ruang norm yang lengkap, dikatakan lengkap jika barisan Cauchy tersebut konvergen. Penelitian ini bertujuan untuk mengetahui pembuktian titik tetap di ruang Banach dengan kondisi yang diberikan yaitu pada pemetaan Kannan dan pemetaan Fisher. Berdasarkan hasil pembahasan, diperoleh bahwa pemetaan Kannan dan pemetaan Fisher mempunyai titik tetap yang tunggal 𝑇(𝑥)=𝑥 dan pemetaan tersebut merupakan pemetaan titik tetap terhadap dirinya sendiri di ruang metrik lengkap
|
2022-05-13T00:57:32.969Z
|
139,569,504 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5781/JWJ.2018.36.1.4",
"MAG": "2784915816",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract The stability of industry market is also diversifying and being demanded with the concept of selecting lightweight and high strength materials. The titanium materials have been come into the spotlight as materials that meet these needs. Primarily, it affects the improvement in performance of industrial energy products such as plate heat exchangers. Therefore, It is necessary to use disk laser welding, which has the best beam characteristic among industrial lasers to contribute in the production. However, the researches of titanium materials have only been limited to achieve optimal results in implementing to the industry. In this study, an experimental method was established by using the orthogonal array table in the Taguchi method, and the SNR is output to the tensile strength. The experimental results has been employed for the influence of laser welding parameters on the weld shape, quality and mechanical properties of 0.6 mm thick lap joints of titanium alloy Ti (ASTM-B265 Grade 1) welded with a new generation disk laser TRUMPF TRUDISK 3302, emitting at 1030 nm, with maximum output power 3.3 kW at circular laser beam spot. As a result, the optimal welding parameters for the lap welding of pure titanium material were predicted as the welding speed of 2m/min, the laser power of 1.5 kW, the top shielding gas flow rate of 30l/min and the bottom shielding gas flow rate of 10l/min.
|
2022-07-23T11:42:10.990Z
|
108,963,985 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3141/1946-13",
"MAG": "2012300029",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Existing practices for acceptance of hot-mix asphalt are based on parameters such as adequate density, adequate thickness, and adequate air voids of the placed and compacted materials. Current mechanistic routines for structural design of flexible pavements consider mainly the modulus of each layer. Therefore, a procedure to measure the modulus of each pavement layer shortly after placement is highly desired. Laboratory tests on specimens prepared from material retrieved during construction, such as the simple-performance tests, can be used to determine these moduli. However, these methods are time-consuming, and the equipment costs are high. In addition, prepared specimens may not be representative of as-placed materials. Seismic tests are more practical because they are rapid to perform and are nondestructive, immediate results are obtained, and the material is tested in its natural state. The portable seismic property analyzer (PSPA) is an example of such a device. The PSPA is presented as a real-time ...
|
2022-09-12T03:39:32.834Z
|
9,283,039 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/1097-0274(200012)38:6<723::AID-AJIM11>3.0.CO;2-G",
"MAG": "2126196816",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In 1957, the leading British asbestos companies (Turner & Newall, Cape Asbestos, and British Belting & Asbestos) founded the Asbestosis Research Council (ARC). This was a response to rising asbestosis and asbestos cancer mortality in the UK and the attendant political and social problems that threatened the existence of the asbestos industry. An ARC research program was launched, that by the 1970s was mainly based within the Institute of Occupational Medicine at Edinburgh University. By the end of the 1980s, well over a hundred papers had been published with ARC support. The bulk of the work involved animal experiments and the chemical analysis of fibers, but the asbestos companies showed little enthusiasm for wider epidemiological studies or for exploring the cancer threat. The sponsoring companies dictated the ARC's research strategy and also vetted (and sometimes censored) publications; while using the ARC as a counterweight to government regulation and media attacks. The ARC's history highlights the compromises that were made by individual scientists and demonstrates the dilemmas inherent in industry-controlled research.
|
2022-09-15T09:24:06.580Z
|
118,194,517 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1360/04EZ0011",
"MAG": "203171353",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In view of river functions and the Minimum Water Demand for River Ecosystem (MWDRE), the water resources in the Lower Yellow River is further divided into three portions, i.e. water available for ecosystem (WE), water exploitable for socioeconomic purposes (WS) and excess flood water (WF). Corresponding conceptions and practical significances are expounded in details. The annual amount of the three portions of water resources from 1950 to 2001 is worked out on the basis of the daily hydrologic data, and the division of different portions is discussed. The results indicate that although the essential water demand for river functions is considered preferentially, the amount of the WE has decreased dramatically while its proportion increased gradually since the 1950s, and the shortage to the MWDRE increased markedly; both the amount and the proportion of the WS decreased notably. Since the 1990s, the actual water consumption for socioeconomic purposes in the lower reaches of the river basin has already exceeded the maximum amount of the WS and has to take over the WE which is already insufficient, hence not only the normal river functions are further disturbed and the river course shrinks greatly, but also the proportion and potential danger of the WF show no decreasing tendency in spite of the sharp decrease of upstream runoff.
|
2022-02-09T22:50:53.811Z
|
195,829,613 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1192/bjb.2019.24",
"MAG": "2962444470",
"PubMedCentral": "6642993"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C856514C9E6F2349FF4C902DC479DF44/S205646941900024Xa.pdf/div-class-title-how-long-is-too-long-div.pdf"
}
|
Summary Forensic psychiatric services care for patients who present with a mental disorder as well as a risk to themselves or others, and have usually been convicted of an offence. Their needs are complex and the length of stay (LoS) in forensic settings is long. LoS is affected by patient factors as well as legal and policy issues. Owing to the considerable economic and ethical issues surrounding lengthy stays in highly restrictive settings, it is crucial that a strategy is developed for how to deal with this patient group. Declaration of interest None.
|
2022-10-22T06:22:00.168Z
|
17,148,644 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICISIP.2005.1529456",
"MAG": "2185156087",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Over the past decade, the field of automated intelligent transport systems has been the focus of intensive research. This paper proposes an intelligent neural network based driving system using artificial net extension (INDSANE), an advanced automated transport system with considerable advantages over previous attempts in this field. The system uses a multi-layer feed-forward neural network with back propagation learning. In addition, the design of INDSANE involves the convergence of a plethora of technologies like a global positioning system (GPS), a geographic information system (GIS), and laser ranging. INDSANE can guide mobile agent through a hostile and unfamiliar domain after being trained by a human user with domain expertise. One of the many areas in which INDSANE scores against the competition is that the system is completely domain independent and incurs a lot less processor overhead. INDSANE thus provides more functionality even though it requires a lot less input as compared to other attempts in this field. This reduction in the size of the input vector translates into more efficient and faster processing. Another of INDSANE's hallmark features is its ability to negotiate turns and implement lane-changing maneuvers with a view to overtaking obstacles. It does this by employing a novel technique, selective net masking. INDSANE also employs a technique called artificial net extension for negotiating traffic signals. A simulation of INDSANE's neural network was performed on a variety of network topologies, and the best network selected.
|
2022-02-13T00:43:19.998Z
|
26,706,503 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/JVI.78.2.798-810.2004",
"MAG": "2063918211",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT African green monkeys (AGMs) infected by simian immunodeficiency virus (SIV) SIVagm are resistant to AIDS. SIVagm-infected AGMs exhibit levels of viremia similar to those described during pathogenic human immunodeficiency virus type 1 (HIV-1) and SIVmac infections in humans and macaques, respectively, but contain lower viral loads in their lymph nodes. We addressed the potential role of dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN; CD209) in viral dissemination. In previous studies, it has been shown that human DC-SIGN and macaque DC-SIGN allow transmission of HIV and SIVmac to T cells. Here, we looked at the ability of DC-SIGN derived from AGM lymph nodes to interact with SIVagm. We show that DC-SIGN-expressing cells are present mainly in the medulla and often within the cortex and/or paracortex of AGM lymph nodes. We describe the isolation and characterization of at least three isoforms of dc-sign mRNA in lymph nodes of AGMs. The predicted amino acid sequence from the predominant mRNA isoform, DC-SIGNagm1, is 92 and 99% identical to the corresponding human and rhesus macaque DC-SIGN amino acid sequences, respectively. DC-SIGNagm1 is characterized by the lack of the fourth motif in the repeat domain. This deletion was also detected in the dc-sign gene derived from thirteen animals belonging to five other African monkey species and from four macaques (Macaca fascicularis and M. mulatta). Despite three- to seven-amino-acid modifications compared to DC-SIGNmac, DC-SIGNagm1 allows transmission of SIVagm to T cells. Furthermore, AGM monocyte-derived dendritic cells (MDDC) expressed at least 100,000 DC-SIGN molecules and were able to transmit SIVagm to T cells. At a low multiplicity of infection (10−5 50% tissue culture infective doses/cell), viral transmission by AGM MDDC was mainly DC-SIGN dependent. The present study reveals that DC-SIGN from a natural host species of SIV has the ability to act as an efficient attachment and transmission factor for SIVagm and suggests the absence of a direct link between this ability and viral load levels in lymph nodes.
|
2022-12-17T22:29:42.220Z
|
53,975,647 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1098/rsta.1954.0018",
"MAG": "2047656400",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The main object of the paper is to discuss the possibility of a body of homogeneous fluid acting as a self-exciting dynamo. The discussion is for the most part confined to the solution of Maxwell’s equations for a sphere of electrically conducting fluid in which there are specified velocities. Solutions are obtained by expanding the velocity and the fields in spherical harmonics to give a set of simultaneous linear differential equations which are solved by numerical methods. Solutions exist when harmonics up to degree four are included. The convergence of the solutions when more harmonics are included is discussed, but convergence has not been proved. The simultaneous solution of Maxwell’s equations and the hydrodynamic equations has not been attempted, but a velocity system has been chosen that seems reasonable from a dynamical point of view. A parameter in the velocity system has been adjusted to satisfy the conservation of angular momentum in a rough way. Orders of magnitude are derived for a number of quantities connected with the dynamo theory of terrestrial magnetism. It is concluded that the dynamo theory does provide a self-consistent account of the origin of the earth’s magnetic field and raises no insuperable difficulties in other directions.
|
2022-12-25T18:23:38.569Z
|
113,621,961 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/ECAM-06-2015-0094",
"MAG": "2579444724",
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},
"license": null,
"status": null,
"url": null
}
|
Purpose
The construction industry today is one of the biggest industries in the world. As projects continue to grow in complexity, project management continues to evolve. Contractor selection is a difficult task that owners and project managers face. Although previously researchers have worked on the subject of contractor selection, a comprehensive decision support system for contractor selection has not yet been developed. Recent reports of major delays and cost overruns in mega projects highlight the need for a model that is able to be flexible and comprehensive becomes evident. The paper aims to discuss these issues.
Design/methodology/approach
The research focuses on obtaining insights from field experts using both quantitative and qualitative methods. Then, a model was developed in the light of the data collected. Accordingly, the model was tested on a case study.
Findings
This paper presents a model for contractor selection that is wholesome in its take on the topic. The model incorporates both managerial and technical aspects of the problem. The model was tested on a case study and it was proven to be feasible in real world applications. The contractor selection decision support system serves the needs of both academics and industry managers, as an integral part of project management.
Originality/value
The model presented in this paper is innovative in its take on the problems. MCDA tools have been uniquely modified in this paper to cater to the needs of the selection problem while accounting for the criteria hierarchy that incorporates aspects that are instrumental for proper evaluation of a contractor’s likelihood of success.
|
2023-01-01T19:24:44.565Z
|
128,473,016 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1306/AD4622DB-16F7-11D7-8645000102C1865D",
"MAG": "2026855604",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A reconnaissance grid of 550 mi of Vibroseis data extending from northernmost Vermont to slightly north of Albany, New York, provides a framework for analyzing subsurface structure and stratigraphy of eastern New York and western Vermont. Regional stratigraphic analysis based on outcrop sections indicates northward and eastward thickening of the Cambrian-Ordovician shelf sequence. Synthetic seismograms from wells in Quebec and southwestern Washington County, New York, document this change in the subsurface and correlate the seismic stratigraphy. Seismic data indicate thickening occurs north of the "Whitehall culmination," an approximately 40-mi long buttress area of Adirondack Grenville basement. Changes in thickness appear to be gradual and not fault controlled. Foreland thrust systems of New York and Vermont relate via a displacement transfer or lateral ramp zone associated with the "Whitehall culmination." Both thrust systems accomplish final emplacement of metamorphic sheets, deform them, and transport shelf material, which is predominantly shale in New York with increased percentage of carbonates in Vermont. Deflection of several major structural elements illustrates the culmination's buttress effect. Subsurface structural elements in New York include western graben, central horst block, and eastern fault-zone trends. No analogous trends have been identified in Vermont where predominant faulting is down-to-the-east. Significantly, in southwestern Washington County, New York, preexisting horst blocks do not serve as ramps to deflect thrusts upward. Instead, the Snake Hill-Smiths basin and Schuylerville thrusts shear off the upper sedimentary sequence of the horst and transport it westward. End_of_Article - Last_Page 298------------
|
2022-02-09T15:39:51.976Z
|
17,140,074 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/nano5041810",
"MAG": "1865326262",
"PubMedCentral": "5304798"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2079-4991/5/4/1810/pdf?version=1446024072"
}
|
There is an urgent need to develop in-product covert barcodes for anti-counterfeiting of agrochemicals. This paper reports a new organic nanoparticle-based in-product barcode system, in which a panel of organic phase change nanoparticles is added as a barcode into in a variety of chemicals (herein agrochemicals). The barcode is readout by detecting melting peaks of organic nanoparticles using differential scanning calorimetry. This method has high labeling capacity due to small sizes of nanoparticles, sharp melting peaks, and large scan range of thermal analysis. The in-product barcode can be effectively used to protect agrochemical products from being counterfeited due to its large coding capacity, technical readiness, covertness, and robustness.
|
2022-12-02T11:59:52.963Z
|
248,478,038 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2174/1573405618666220427134647",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
A series of pneumonia cases with clinical presentations of viral pneumonia secondary to new coronavirus and subsequent global transmission arose in Wuhan, Hubei, China, in December 2019. Several cases of coronavirus disease 2019 (COVID-19) have been described incidentally in positron emission tomography-computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) as a result of the pandemic. Herein, we describe the findings of a patient with unknown COVID-19 in PET/CT with the other radiopharmaceutical, 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA).
CASE REPORT
A 69-year-old man had previously undergone radical prostatectomy for adenocarcinoma. 68Ga-PSMA PET/CT imaging was performed due to biochemical recurrence. 68Ga-PSMA uptake in the prostate bed suggestive of local recurrence was detected in PET/CT images. Also, bilateral ground-glass opacities with slightly increased 68Ga-PSMA uptake were seen in the lungs, suspected of COVID-19. A reverse transcription-polymerase chain reaction test has confirmed the infection.
CONCLUSION
Even in asymptomatic patients, nuclear medicine departments must be aware of the possibility of COVID-19, take appropriate post-exposure procedures, and protect employees and other patients.
|
2022-12-07T14:30:32.479Z
|
36,886,015 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/biot.200700206",
"MAG": "1987627388",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Many fluorescent techniques are employed to evaluate the viability and activity of microbial cells used in biotechnology. These techniques are sometimes complex and the interpretation of results opened to misunderstanding. Moreover, new developments are constantly proposed especially concerning a more accurate evaluation of the state of the cells including eukaryotic microorganisms. This paper aims at presenting to biotechnologists unfamiliar with fluorescence the principles of these methods and the related possible pitfalls. It focuses on probes of the physical (integrity and fluidity) and energetical (intracellular pH and membrane potential) state of the cell membrane (bacterial and yeast cells) and presents also other probes (nucleic acids, respiration...) and new technical trends. The specificities of Gram‐negative bacterial cells are also discussed.
|
2022-12-12T08:54:39.312Z
|
8,095,936 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/nar/gkq1214",
"MAG": "2093479877",
"PubMedCentral": "3061069"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://academic.oup.com/nar/article-pdf/39/5/e29/16780645/gkq1214.pdf"
}
|
The visual detection of specific double-stranded DNA sequences possesses great potential for the development of diagnostics. Zinc finger domains provide a powerful scaffold for creating custom DNA-binding proteins that recognize specific DNA sequences. We previously demonstrated sequence-enabled reassembly of TEM-1 β-lactamase (SEER–LAC), a system consisting of two inactive fragments of β-lactamase each linked to engineered zinc finger proteins (ZFPs). Here the SEER–LAC system was applied to develop ZFP arrays that function as simple devices to identify bacterial double-stranded DNA sequences. The ZFP arrays provided a quantitative assay with a detection limit of 50 fmol of target DNA. The method could distinguish target DNA from non-target DNA within 5 min. The ZFP arrays provided sufficient sensitivity and high specificity to recognize specific DNA sequences. These results suggest that ZFP arrays have the potential to be developed into a simple and rapid point-of-care (POC) diagnostic for the multiplexed detection of pathogens.
|
2022-12-15T06:06:45.368Z
|
1,587,187 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2522/ptj.20100030",
"MAG": "2144665535",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/ptj/article-pdf/90/12/1807/24146971/ptj1807.pdf"
}
|
Dramatic changes in the health care landscape over the next few decades undoubtedly will affect rehabilitation specialists' practice. In the multidisciplinary field of regenerative medicine, cell, tissue, or organ substitutes are used to enhance the healing potential of the body. Given that the restoration of normal functioning of injured or diseased tissues is expected to be the ultimate goal of these therapies, the future of regenerative medicine is, undeniably, tightly intertwined with that of rehabilitation. Rehabilitation specialists not only must be aware of cutting-edge medical advances as they relate to regenerative medicine but also must work closely with basic scientists to guide the development of clinically relevant protocols. The purposes of this article are to provide a current perspective on biological approaches to the management of musculoskeletal disorders and to highlight the needed integration of physical therapeutics with regenerative medicine.
|
2022-12-20T04:18:04.676Z
|
20,651,934 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/15622975.2017.1417639",
"MAG": "2775847323",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Objectives: Two recent scientific breakthroughs may alter the treatment of mental illness, as discussed in this narrative review. The first was the invention of white light-emitting diodes (LEDs), which enabled an ongoing, rapid transition to energy-efficient LEDs for lighting, and the use of LEDs to backlight digital devices. The second was the discovery of melanopsin-expressing photosensitive retinal ganglion cells, which detect environmental irradiance and mediate non-image forming (NIF) functions including circadian entrainment, melatonin secretion, alertness, sleep regulation and the pupillary light reflex. These two breakthroughs are interrelated because unlike conventional lighting, white LEDs have a dominant spectral wavelength in the blue light range, near the peak sensitivity for the melanopsin system. Methods: Pertinent articles were identified. Results: Blue light exposure may suppress melatonin, increase alertness, and interfere with sleep in young, healthy volunteers and in animals. Areas of concern in mental illness include the influence of blue light on sleep, other circadian-mediated symptoms, prescribed treatments that target the circadian system, measurement using digital apps and devices, and adolescent sensitivity to blue light. Conclusions: While knowledge in both fields is expanding rapidly, future developments must address the potential impact of blue light on NIF functions for healthy individuals and those with mental illness.
|
2022-12-20T13:52:06.195Z
|
38,361,303 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/00005768-199703000-00013",
"MAG": "2064662085",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study was conducted to compare gross efficiency (GE), net efficiency (NE), work efficiency (WE), and delta efficiency (DE) between arm crank and cycle exercise at the same relative intensities. Eight college-aged males underwent two experimental trials presented in a randomized counterbalanced order. During each trial subjects performed three intermittent 7-min exercise bouts separated by 10-min rest intervals on an arm or semirecumbent leg ergometer. The power outputs for the three bouts of arm crank or cycle exercise corresponded to 50, 60, and 70% of the mode-specific VO2peak. GE, NE, and WE were determined as the ratio of Kcal.min-1 equivalent of power output to Kcal.min-1 of total energy expended, energy expended above rest and energy expended above unloaded exercise, respectively. DE was determined as the ratio of the increment of Kcal.min-1 of power output above the previous lower intensity to the increment of kcal.min-1 of total energy expended above the previous lower intensity. GE and NE did not differ between arm crank and cycle exercises. However, WE was lower (P < 0.05) during arm crank than cycle exercise at 50, 60, and 70% VO2peak. DE was also lower (P < 0.05) during arm crank than cycle exercise at delta 50-60 and at delta 60-70% VO2peak. It is concluded metabolic efficiency as determined by work and delta efficiency indices was lower during arm crank compared with cycle exercise at the same relative intensities. These findings add to the understanding of the difference in metabolic efficiency between upper and lower body exercise.
|
2022-12-24T14:42:36.897Z
|
153,647,574 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/OEP/52.4.702",
"MAG": "1920092089",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We compare the efficiency and equity effects of three financing systems for higher education: the traditional tax-subsidy system, where education subsidies are financed from general taxation; loan schemes; and a graduate tax. We find that efficiency and equity targets cannot be simultaneously achieved by the traditional tax-subsidy system, and that both loan schemes and a graduate tax fare better. When education outcomes are uncertain, the graduate tax is to be preferred to a pure loan scheme because of the greater insurance provided by the former and because it tends to be preferable to an income contingent loan system. Copyright 2000 by Oxford University Press.
|
2022-12-15T01:08:20.041Z
|
146,299,657 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3112/SPEED.V7I2.1283",
"MAG": "2219948632",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT :The Be Excellent Learning Institute Mentoring of Pacitan is one of the institution who develop rapidly, it can be seen from amount of students that studies there and the amount of teachers. The increasing of amount of students day each day make this institution face difficulties to manage the payment of students. This instituion no use information system yet, due to it in this research will developed one of payment system. This information system called payment information system for course at Be Excellent Learning Institute Mentoring of Pacitan This thesis will explain the activities and results produced from each process. Design Payment Information System for Course conducted completely, while its implementation are limited only in input data, search data and conclude data. All of the step that has be done or has not yet, it will be discussed in the end of the finall task. Therefore, in this thesis,the payment system as a solution to break the difficulties that frequently faced by administrator. So the payment process can more efective and efficient. Key words : Information system, payment ABSTRAKSI : Lembaga Bimbingan Belajar Be Excellent Pacitan merupakan salah satu lembaga yang mengalami perkembangan sangat pesat, dilihat dari semakin banyaknya siswa yang belajar di Lembaga tersebut dan jumlah pengajar. Jumlah siswa yang semakin hari semakin bertambah membuat Lembaga ini mengalami permasalahan dalam hal pengolahan data pembayaran siswa. Lembaga Bimbingan Belajar Be Excellent Pacitan belum memanfaatkan sistem informasi. Oleh karena itu, dalam proposal ini akan dikembangkan suatu model sistem pembayaran. Sistem informasi ini dinamakan Sistem Informasi Pembayaran Les pada Lembaga Bimbingan Belajar Be Excellent Pacitan. Penelitian ini akan menguraikan aktivitas-aktivitas dan produk-produk yang dihasilkan dari proses. Desain Sistem Informasi Pembayaran Les dilakukan secara lengkap, sedangkan implementasinya dibatasi hanya pada proses pemasukan data, pencarian data, dan perekapan data. Hal-hal apa yang telah dilakukan dan apa yang belum dilakukan pada pembuatan sistem ini akan diulas pada bagian akhir Tugas Akhir ini. Pada penelitian ini sistem pembayaran dapat menjawab kesulitan yang sering dihadapi oleh petugas administrasi sehingga proses pembayaran dan pengolahan data pembayaran bisa dilakukan dengan efektif dan efisien. Kata kunci : Sistem informasi, pembayaran
|
2022-02-09T05:59:48.418Z
|
5,324,707 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/MAHC.2001.948912",
"MAG": "1988642896",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Alvarez) says that the “story is as exciting as a spy novel.” The book does contain a considerable amount of technical information on codebreaking, which some readers may wish to reread after having finished the book. Further technical details are given in several appendices. There are 40 pages of notes, a two-page glossary, a 10-page bibliography, and a very useful index. Battle of Wits gives a brief introduction to the nature of cryptography and cryptanalysis, followed by a discussion of the work of British and American codebreakers between the two World Wars, and also of the Polish Cipher Bureau and its work in breaking the Enigma code in the 1930s. The book then gives an account of the development of codebreaking activities by the Allies and the vital role codebreaking played during World War II (including the Battle of the Atlantic, the Mediterranean theatre, the Allied invasion of Europe, and the war in the Pacific). The origins, development, and use of the Enigma machines by the Germans for cryptography are described in detail, as are the mathematical methods and the mechanical, electromechanical, and electronic machines used by the British and the Americans in breaking the Enigma code. Budiansky’s portrayal of some of the persons involved in codebreaking contributes considerably to the historical and technical accounts. Of particular interest are Marian Rejewski (who was one of the central figures in the Polish codebreaking activities in the 1930s), Joseph Rochefort (who was in charge of breaking the Japanese AN-25 naval code used at Midway), William Friedman (who broke the Japanese diplomatic Purple code), Herbert Yardley (whose inglorious career spanned the United States, Chiang Kai-shek’s China, and even Canada), and Dillwyn Knox and Alan Turing in Great Britain. Ian Fleming even makes an appearance in a role suggestive of the exploits of his later fictional hero James Bond. Readers with a computing background will be fascinated by the author’s accounts of the manual and mechanical means used in cryptanalysis, including conventional IBM punchedcard equipment. Some will keep thinking how the analyses could be so much more simply and expeditiously done with the hardware and software available today, and may even speculate on the computational methods used by present-day cryptographers and cryptanalysts. The following example (from p. 33) of the randomization method used in compiling a new code book for the US War Department in the 1930s may both amuse the reader and indicate how far computational tools have evolved since then: ...they entered sixty thousand words in alphabetical order on three-by-five index cards, also by hand. The cards then had to be placed in a random order so they could each be assigned a fiveletter code group; the solution was to push the furniture aside to clear a space in the secure vault where they worked, then throw the cards into a stream of air from a fan. When the cards landed on the floor they were given a final stirring, then picked up.
|
2022-02-13T11:00:36.804Z
|
132,212,231 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1504/IJIEI.2019.10020458",
"MAG": "2926525040",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The surgical robotic system, a tele-robotic system, comprises the operator, master-slave configuration in combination with the object. For the estimation and control of the surgical robotic system, the master-slave set up is the subject of greater robotic research activities as well as has proven promising. In this paper, the multi-dimensional stochastic differential equation as well as the higher-order nonlinear stochastic filter beyond extended Kalman filtering for a master robot of the surgical robotic system are developed. The higher-order nonlinear filtering preserves the greater qualitative characteristics of nonlinear stochastic systems by accounting observation correction terms in stochastic evolution equations. First, the Lagrangian mechanics is exploited to develop the vector stochastic model of the master robot. Secondly, this paper utilises the Kushner-Stratonovich equation, for filtering of the master robot noise equations. This paper demonstrates comparison between the higher-order Kushner-Stratonovich filter, extended Kalman filter and true state trajectories as well.
|
2022-07-01T00:29:05.603Z
|
218,562,341 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/a-1071-2419",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Alternaria alternata spores are important allergens causing "hayfever". Outdoor fungal exposure is primarily associated with increased asthma symptoms and increased risk of asthma exacerbations. In our outpatient-clinic, we investigated patients who presented with symptoms of allergic conjunctivitis and respiratory symptoms in the summertime. We found a sensitisation to Alternaria alternata in about 6 % of the investigated patients. Especially in children and teenagers, the sensitisation is clinically important. The spores of Alternaria alternata are responsible for the development and persistence of nonspecific airway hyperresponsiveness and in a group of patients also for a difficult-to-treat asthma in the summer. We should always bear in mind that prolonged symptoms (after end of June) in grass pollen allergic patients might be caused by additional sensitisation to Alternaria alternata spores or mugwort pollen. In our patients, we were able to show a sensitisation to Alternaria alternata in grass pollen allergic patients rather frequently. In the summertime, high counts of Alternaria spores and pollen often appear simultaneously. Our findings show a considerable effect of Alternaria sensitisation on the asthma morbidity and exacerbations. In this article we refer to the necessity of keeping a patient diary of allergic symptoms and the importance of information from regional pollen traps about the counts of pollen and Alternaria spores. Only then we will be able to differentiate, which allergen is responsible for the severe "hay fever", especially in patients with severe asthma episodes. Before the start of a specific immunotherapy with Alternaria alternata it is recommended to perform a mucosal provocation test, to prove the clinical significance of the sensitisation. It has been shown that also in Germany, there are high counts of Alternaria spores in the summer. The results of the pollen and alternaria count in the year 2009, measured in the regional pollen trap (Treuenbrietzen), are shown in Abb. 1, 2, 3, 4, 5. We have also found broken Alternaria spores. They are associated with increased asthma exacerbations and appear often during thunderstorms and harvesting. An allergen-specific immunotherapy with Alternaria alternata is a safe treatment and it is effective in improving respiratory function. The safety and efficacy is comparable to the one found in the allergen-specific immunotherapy with pollen.
|
2022-07-31T22:30:21.452Z
|
201,120,623 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1524/ncrs.2006.0110",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://www.degruyter.com/document/doi/10.1524/ncrs.2006.0110/pdf"
}
|
Abstract C19H21NO4, orthorhombic, P212121 (no. 19), a = 10.817(2) Å, b = 11.463(2) Å, c = 13.025(2) Å, V = 1615.0 Å3, Z = 4, Rgt(F) = 0.038, wRref(F2) = 0.083, T = 297 K.
|
2022-11-18T00:37:43.258Z
|
249,723,818 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1538-7445.am2022-3580",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The introduction of checkpoint blockade therapy, specifically anti-PD-1/PD-L1 agents, has transformed the treatment landscape of advanced Non-Small Cell Lung Cancer (NSCLC). While our understanding of the biology underlying immunotherapy in NSCLC is still incomplete, studies to date have established central roles for Tumor Mutation Burden (TMB) and PD-L1 Tumor Proportion Score (PDL1-TPS). In order to expand our understanding of the molecular features underlying response in NSCLC, we describe here the first joint analysis of the Stand Up 2 Cancer-Mark Foundation (SU2C-MARK) Cohort, a collection of 393 patients with whole exome and/or RNA sequencing along with matched checkpoint blockade response annotation. We identify a number of significant associations between molecular features and response, including: 1) favorable and unfavorable genomic subgroups; 2) distinct immune infiltration signatures associated with wound healing (unfavorable) and immune activated (favorable) microenvironments; and 3) a novel de-differentiated tumor-intrinsic subtype characterized by high TMB, immune activation, and enhanced response rate. Taken together, results from this cohort extend our understanding of NSCLC-specific predictors, providing a rich set of molecular and immunologic hypotheses with which to further our understanding of the biology of checkpoint blockade in NSCLC.
Citation Format: Arvind Ravi, Justin Gainor, Monica Arniella, Chip Stewart, Sam Freeman, Mark M. Awad, Patrick Forde, Valsamo Anagnostou, Brian Henick, Jonathan W. Riess, Don Gibbons, Nathan Pennell, Vamisdhar Velcheti, Ignaty Leshchiner, Jaegil Kim, Subba Digumarthy, Mari Mino-Kenudson, John Heymach, Natalie Vokes, Andrew Griffin, Biagio Ricciuti, Naiyer Rizvi, Roy Herbst, Victor Velculescu, Julie Brahmer, Kurt Schalper, Pasi Janne, Jedd Wolchok, Alice Shaw, Nir Hacohen, Gad Getz, Matthew D. Hellmann. Integrative genomics of checkpoint blockade response in advanced non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3580.
|
2022-06-17T17:02:10.676Z
|
49,412,645 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fspas.2018.00021",
"MAG": "2806881737",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fspas.2018.00021/pdf"
}
|
To make transformational scientific progress with the space weather enterprise the Sun, Earth, and heliosphere must be studied as a coupled system, comprehensively. Rapid advances were made in the study, and forecasting, of terrestrial meteorology half a century ago that accompanied the dawn of earth observing satellites. Those assets provided a global perspective on the Earthâs weather systems and the ability to look ahead of the observerâs local time. From a heliospheric, or space, weather perspective we have the same fundamental limitation as the terrestrial meteorologists had \-- by far the majority of our observing assets are tied to the Sun-Earth line \-- our planetâs ``local time'' with respect to the Sun. This perspective intrinsically limits our ability to ``see what is coming around the solar limb'' far less to gain any insight into the global patterns of solar weather and how they guide weather throughout the heliosphere. We propose a mission concept \-- the Heliospheric Meteorology Mission (HMM) \-- to sample the complete magnetic and thermodynamic state of the heliosphere inside 1AU using a distributed network of deep space hardened smallsats that encompass the Sun. The observations and in situ plasma measurements made by the fleet of HMM smallsats would be collected, and assimilated into current operational space weather models. Further, the HMM measurements would also being used in an nationally coordinated research effort - at the frontier of understanding the coupled heliospheric system.
|
2022-12-21T01:40:02.592Z
|
238,928,655 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5114/ceji.2021.108180",
"MAG": "3188524902",
"PubMedCentral": "8568027"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://www.termedia.pl/Journal/-10/pdf-44848-10?filename=Increase in CD5L.pdf"
}
|
Introduction Obesity appears to be a powerful risk factor for the development of knee osteoarthritis (KOA), but the mechanisms of this are not fully understood. CD5L is expressed in tissue macrophages and is increased in obese mice. We hypothesized that CD5L expression is increased in the synovial membrane (SM) of obese KOA patients. Here, we investigated CD5L expression in the SM of these patients. Material and methods Ninety KOA patients (26 males, 64 females) were allocated to one of three groups based on body mass index (BMI): normal weight (NW, < 25 kg/m2), overweight (OW, 25-29.99 kg/m2) and obese (OB, ≥ 30 kg/m2), according to the World Health Organization BMI classification (each n = 30). Expression of CD5L in SM among the groups was compared using real-time polymerase chain reaction. To investigate CD5L-expressing cells in SM, CD14+ (macrophage fraction) and CD14– (fibroblast fraction) cells were separated from the SM. Results CD5L expression was significantly higher in the OB group than in the NW and OW groups (p < 0.001). CD5L expression was observed in the CD14+ fraction but not in the CD14– fraction. Conclusions CD5L is highly expressed in the SM of KOA patients with obesity. Further investigation is required to identify the role of CD5L in the relationship between KOA pathology and obesity.
|
2022-12-25T23:08:54.689Z
|
242,451,626 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31219/osf.io/xkqmv",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://osf.io/xkqmv/"
}
|
Latar Belakang: Pada saat melakukan implementasi perawat harus melaksanakan hasil dari rencana keperawatan yang di lihat dari diagnosa keperawatan. Di mana perawat membantu klien dari masalah status kesehatan yang dihadapi ke status kesehatan yang lebih baik yang menggambarkan kriteria hasil yang diharapkan.Tujuan: untuk mengetahui bagaimana dan pentingnya melakukan pelaksanaan asuhan keperawatan oleh perawat di rumah sakit. Metode: Dengan menggunakan metode literature Riview, yaitu dengan menganalisis buku atau jurnal dengan berfokus kan pada metode pelaksanaan asuhan keperawatan. Hasil: meliputi bagaimana pelaksanaan dalam asuhan keperawatan. Dari hasil ini kita dapat mengetahui pentingnya perawat melakukan pelaksanaan asuhan keperawatan oleh perawat dengan benar,Pembahasan: Implementasi keperawatan adalah serangkaian kegiatan yang dilakukan oleh perawat untuk membantu pasien dari masalah status kesehatan yang dihadapi kestatus kesehatan yang lebih baik yang menggambarkan kriteria hasil yang diharapkan. Penutup: pelaksanaan dalam asuhan keperawatan itu sangat penting karena perawat harus mampu dan tanggung jawab dalam tugasnya memberikan bentuk pelayanan yang tepat atau melakukan implementasi dengan baik dan benar dalam keperawatan.
|
2022-01-24T21:04:58.210Z
|
244,625,963 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26807/REMCB.V42I1.907",
"MAG": "3206281925",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ha transcurrido un poco más de un año desde que la Organización Mundial de la Salud declarara a la infección por el virus SARS-CoV-2 como una pandemia y por supuesto casi 18 meses desde que se reportaron los primeros casos de la COVID-19 en Wuhan, China. Difícilmente alguien, en pleno siglo XXI, podría haber pensado que un virus iba a cambiar por completo la hegemonía de vida que teníamos, que sería necesario el confinamiento parcial o total, que se suspenderían los viajes, el turismo e inclusive las actividades presenciales como clases, conferencias y demás. Este ha sido un periodo difícil para los investigadores, particularmente para los que hacen investigación experimental, pues sus proyectos han tenido que suspenderse, en muchos casos, o en otros “mutar” hacia temas relacionados a la COVID-19. Esa “covidización” de la investigación, como la denomino el doctor Madhukar Pai (Nat Med. 2020;26(8):1159) hizo que científicos bien intencionados con experticia real en un campo se entrometan en otro, emitiendo juicios cuando carecen de capacitación y conocimiento de nivel experto. Adicionalmente, en muchos países la pandemia motivó la asignación de recursos adicionales o especiales para fomentar la investigación en temas relacionados a la COVID-19, pero no fue el caso de Ecuador, en el que más bien se elaboraron normas y barreras para dificultar la investigación sobre la pandemia (Dev World Bioeth. 2021;21(1):3-6). Sin embargo, y frente a estas adversidades, parece que los científicos ecuatorianos encontraron la oportunidad de “desempolvar” sus datos guardados, ponerse al día con sus pendientes o simplemente maximizar sus colaboraciones, logrando que la producción reflejada en PubMed suba de 1136 registros en todo el 2019 a 1833 registros hasta el 30 de marzo del 2021 (+61%). Es interesante, además, resaltar que de acuerdo al Observatorio Iberoamericano de la Ciencia, Tecnología y la Sociedad (http://octs.ricyt.org/reportes/explorador.html) en el Ecuador solo hay 117 publicaciones relacionadas a COVID-19, a pesar de haber sido uno de los países más severamente afectados por esta pandemia.
|
2022-01-27T08:42:40.069Z
|
125,296,796 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.2243286",
"MAG": "2565718809",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The energy transferring between three q-bits system flying simultaneously through an optical cavity, is discussed. It is observed the migration of energy from one excited radiator with dipole forbidden transitions relatively to another two- radiators with half excitation energy of first atom. Photon entangled state between distinct atoms and their transfer is studied. These atoms in our interpretations are named, D - dipole forbidden atom, S1 and S2 - two dipole active atoms with summer energy ћɷ1 + ћɷ2 = ћɷn, ɷ1 observe the periodical transfer of energy from D- atom to ensemble of two S- atoms. This effect may be used for quantum gates processing in which the energy transfer depends on the input information. The quantum discord and entanglement for this system of q-bits was explored.
|
2022-02-09T18:15:46.475Z
|
145,295,739 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0960777302004083",
"MAG": "2079995751",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Jean-Jacques Renoliet, L'UNESCO oubliée. La Société des Nations et la coopération intellectuelle (1919–1946), foreword by René Girault (Paris: Publications de la Sorbonne, 1999), 352 pp., FF180, ISBN 2-6384-7701-1. Christel Taillibert, L'Institut international du cinématographe international éducatif. Regards sur le rôle du cinéma éducatif dans la politique internationale du fascisme italien (Paris: L'Harmattan, 1999), 401 pp., FF180, ISBN 2-85944-384-3. Marta Aleksandra Balińska, Une vie pour l'humanitaire. Ludwik Rajchmann, 1881–1965, foreword by Bronislaw Geremek, L'Espace de l'histoire (Paris: La Découverte, 1995), 399 pp., FF165, ISBN 2-7071-2485-0.
|
2022-08-27T17:35:06.257Z
|
251,998,026 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/p-yza5n0",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Three formulations intended for NSF H1 food-grade grease were prepared in this study comprising paraffin oil as a base oil and fumed silica as a thickener. No additive was added in formulation 1 (F1) and formulation 2 (F2), whereas chitosan was added in formulation 3 (F3) as an additive. A commercial food-grade grease (FGG) was used for comparison purposes. The formulated greases and the commercial FGG were characterised for thermal stability via thermogravimetric analysis (TGA) and derivative thermogravimetric analysis (DTG). Fourier-transform infrared (FTIR) spectroscopy, dropping point, oil separation, and consistency tests were also carried out to evaluate the properties of the greases. The FTIR spectra were obtained for the fresh and aged greases for grease characterisation. The results showed that the grease made with chitosan as an additive demonstrated higher oil separation, better consistency, and was less affected by ageing, as indicated by the change of grease colour after the oil separation test. F1, F2, F3, and the commercial FGG recorded dropping points higher than 350 °C, indicating no dropping point properties for the tested greases. The grease formulated with chitosan (F3) achieved the highest oil separation with 1.21%, while the commercial FGG recorded the lowest oil separation with 0.66%, followed by F1 and F3 with the oil separation of 0.99% and 0.98%, respectively. For the consistency test, the NLGI number for each formulation varied but the commercial FGG showed the lowest NLGI number of 2, whereas F3 showed the NLGI number in the range of 2–3, and F1 showed the NLGI number of 3. The aged grease of F3 had unchanged consistency after the oil separation test. Based on the results, the formulated greases have acceptable properties in comparison to the commercial FGG, and the addition of chitosan contributes positively to the grease characteristics.
|
2022-09-05T18:35:50.495Z
|
11,260,403 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/2536764.2536773",
"MAG": "1964853029",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://www.isle.uiuc.edu/%7Esborys/Saliency_audio_visualization-Lin.pdf"
}
|
Browsing large audio archives is challenging because of the limitations of human audition and attention. However, this task becomes easier with a suitable visualization of the audio signal, such as a spectrogram transformed to make unusual audio events salient. This transformation maximizes the mutual information between an isolated event's spectrogram and an estimate of how salient the event appears in its surrounding context. When such spectrograms are computed and displayed with fluid zooming over many temporal orders of magnitude, sparse events in long audio recordings can be detected more quickly and more easily. In particular, in a 1/10-real-time acoustic event detection task, subjects who were shown saliency-maximized rather than conventional spectrograms performed significantly better. Saliency maximization also improves the mutual information between the ground truth of nonbackground sounds and visual saliency, more than other common enhancements to visualization.
|
2022-09-12T09:11:47.906Z
|
21,226,112 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICIT.2008.4608544",
"MAG": "2108552280",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents the identification of the linear parameters of a salient-pole synchronous machine at standstill by frequency response tests data (SSFR). The procedure consists in defining and conducting the frequency response tests, identifying the model structure, estimating the machine parameters. The parameters of operational impedances or in other terms, the reactances and the time constants are estimated. The obtained results are presented from tests on the synchronous machine of 1,5 kVA/380 V/1500 rpm.
|
2022-09-20T23:39:54.233Z
|
205,203,397 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/14651858.CD010136.pub2",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Dental pain can have a considerable detrimental effect on an individual's quality of life. Symptomatic apical periodontitis and acute apical abscess are common causes of dental pain and arise from an inflamed or necrotic dental pulp, or infection of the pulpless root canal system. Clinical guidelines recommend that the first-line treatment for teeth with symptomatic apical periodontitis or an acute apical abscess should be removal of the source of inflammation or infection by local, operative measures, and that systemic antibiotics are currently only recommended for situations where there is evidence of spreading infection (cellulitis, lymph node involvement, diffuse swelling) or systemic involvement (fever, malaise). Despite this, there is evidence that dentists continue to prescribe antibiotics for these conditions. There is concern that this could contribute to the development of antibiotic-resistant bacterial colonies both within the individual and within the community as a whole.
OBJECTIVES
To evaluate the effects of systemic antibiotics provided with or without surgical intervention (such as extraction, incision and drainage of a swelling or endodontic treatment), with or without analgesics, for symptomatic apical periodontitis or acute apical abscess in adults.
SEARCH METHODS
We searched the following electronic databases: Cochrane Oral Health Group's Trials Register (to 1 October 2013); Cochrane Central Register of Controlled Trials (The Cochrane Library 2013, Issue 9); MEDLINE via OVID (1946 to 1 October 2013); EMBASE via OVID (1980 to 1 October 2013) and CINAHL via EBSCO (1980 to 1 October 2013). We searched the World Health Organization (WHO) International Trials Registry Platform and the US National Institutes of Health Trials Registry (ClinicalTrials.gov) on 1 October 2013 to identify ongoing trials. We searched for grey literature using OpenGrey (to 1 October 2013) and ZETOC Conference Proceedings (1993 to 1 October 2013). We placed no restrictions on the language or date of publication when searching the electronic databases.
SELECTION CRITERIA
Randomised controlled trials of systemic antibiotics in adults with a clinical diagnosis of symptomatic apical periodontitis or acute apical abscess, with or without surgical intervention (considered in this situation to be extraction, incision and drainage or endodontic treatment) and with or without analgesics.
DATA COLLECTION AND ANALYSIS
Two review authors screened the results of the searches against inclusion criteria, extracted data and assessed risk of bias independently and in duplicate. We calculated mean differences (MD) (standardised mean difference (SMD) when different scales were reported) and 95% confidence intervals (CI) for continuous data and, where results were meta-analysed, we used a fixed-effect model as there were fewer than four studies. We contacted study authors to obtain missing information.
MAIN RESULTS
We included two trials in this review, with 62 participants included in the analyses. Both trials were conducted in university dental schools in the USA and compared the effects of oral penicillin V potassium (penicillin VK) versus a matched placebo given in conjunction with a surgical intervention (total or partial pulpectomy) and analgesics to adults with acute apical abscess or symptomatic necrotic tooth (no signs of spreading infection or systemic involvement (fever, malaise)). We assessed one study as having a high risk of bias and the other study as having unclear risk of bias.The primary outcome variables presented were participant-reported pain and swelling (one trial also reported participant-reported percussion pain). One study reported the type and number of analgesics taken by participants. One study recorded the incidence of postoperative endodontic flare-ups (people who returned with symptoms that necessitated further treatment). Adverse effects as reported in one study were diarrhoea (one participant, placebo group) and fatigue and reduced energy postoperatively (one participant, antibiotic group). No studies reporting quality of life measurements were suitable for inclusion. Objective 1: systemic antibiotics versus placebo with surgical intervention and analgesics for symptomatic apical periodontitis or acute apical abscess. Two studies provided data for the comparison between systemic antibiotics (penicillin VK) and a matched placebo for adults with acute apical abscess or a symptomatic necrotic tooth. Participants in one study all underwent a total pulpectomy of the affected tooth while participants in the other study had their tooth treated by either partial or total pulpectomy. Participants in both trials received oral analgesics. There were no statistically significant differences in participant-reported measures of pain or swelling at any of the time points assessed within the review. The MD for pain (short ordinal numerical scale 0 to 3) was -0.03 (95% CI -0.53 to 0.47) at 24 hours; 0.32 (95% CI -0.22 to 0.86) at 48 hours and 0.08 (95% CI -0.38 to 0.54) at 72 hours. The SMD for swelling was 0.27 (95% CI -0.23 to 0.78) at 24 hours; 0.04 (95% CI -0.47 to 0.55) at 48 hours and 0.02 (95% CI -0.49 to 0.52) at 72 hours. The body of evidence was assessed as at very low quality. Objective 2: systemic antibiotics without surgical intervention for adults with symptomatic apical periodontitis or acute apical abscess. We found no studies that compared the effects of systemic antibiotics with a matched placebo delivered without a surgical intervention for symptomatic apical periodontitis or acute apical abscess in adults.
AUTHORS' CONCLUSIONS
There is very low quality evidence that is insufficient to determine the effects of systemic antibiotics on adults with symptomatic apical periodontitis or acute apical abscess.
|
2022-11-16T18:39:39.230Z
|
220,831,413 |
{
"externalids": {
"ACL": null,
"ArXiv": "2007.14165",
"DOI": "10.1103/physrevlett.125.258004",
"MAG": "3045933761",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/2007.14165"
}
|
We use the swap Monte Carlo algorithm to analyze the glassy behavior of sticky spheres in equilibrium conditions at densities where conventional simulations and experiments fail to reach equilibrium, beyond predicted phase transitions and dynamic singularities. We demonstrate the existence of a unique ergodic region comprising all the distinct phases previously reported, except for a phase-separated region at strong adhesion. All structural and dynamic observables evolve gradually within this ergodic region, the physics evolving smoothly from well-known hard sphere glassy behavior at small adhesions and large densities, to a more complex glassy regime characterized by unusually broad distributions of relaxation timescales and length scales at large adhesions.
|
2022-11-16T22:37:48.756Z
|
196,596,535 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/1548728",
"MAG": "2033181622",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
The dromiacean crab species Homolodromia bouvieri, originally described from a small, damaged male from deep waters off the coast of Kenya, is redescribed, based on a male from off the coast of Mozambique, Africa. The specimen is the third known for the species and is significantly larger than the 2 previously known specimens, from off Kenya and Natal. Com parisons are made between H. bouvieri and the other two species in the genus, H. paradoxa and H. robertsi, known from the western Atlantic and eastern Pacific, respectively. Among the many interesting crustaceans collected by the German vessel Valdivia during her 1898-1899 Tiefsee-Expedition were one new genus and three new species of the Dromiacea (Doflein, 1904). One of the new species, Homolodromia bouvieri Doflein, 1904, was represented in the col lections by a single male of 18-mm carapace length collected at Valdivia Station 247, in a depth of 863 m, off the coast of Kenya (03°38.8'S, 40''16.0'E) (Doiein, 1904). The specimen was in very poor condition, ap parently having just completed a molt, and was soft, with several diagnostic features poorly developed. A second specimen, also a male but slightly larger (carapace length including rostrum 22.7 mm), was reported by Kensley (1977) from off Natal, South Africa (Kensley, 1977: 178, figs. 11, 12); that specimen was in better condition, al lowing Kensley (1977) to illustrate several important morphological features. There are no other records of this species in the Uterature.
|
2022-12-13T08:00:57.137Z
|
6,919,684 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/polym9060221",
"MAG": "2627046521",
"PubMedCentral": "6431849"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2073-4360/9/6/221/pdf?version=1497362336"
}
|
The interphase in short fiber thermoplastic composites is defined as a three-dimensional, several hundred nanometers-wide boundary region at the interface of fibers and the polymer matrix, exhibiting altered mechanical properties. This region is of key importance in the context of fiber-matrix adhesion and the associated mechanical strength of the composite material. An interphase formation is caused by morphological, as well as thermomechanical processes during cooling of the plastic melt close to the glass fibers. In this study, significant injection molding processing parameters are varied in order to investigate the influence on the formation of an interphase and the resulting mechanical properties of the composite. The geometry of the interphase is determined using nano-tribological techniques. In addition, the influence of the glass fiber sizing on the geometry of the interphase is examined. Tensile tests are used in order to determine the resulting mechanical properties of the produced short fiber composites. It is shown that the interphase width depends on the processing conditions and can be linked to the mechanical properties of the short fiber composite.
|
2022-12-15T05:40:09.820Z
|
37,682,060 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/LED.2015.2404854",
"MAG": "1987727343",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A highly scalable single poly-silicon multiple time programmable erasable programmable read only memory (EEPROM) with tungsten metallic control gate (W-CG) manufactured by full 0.13 μm-CMOS process is successfully demonstrated in this letter. Since the coupling ratio of conventional EEPROM cell is reduced with decreasing cell size, a smaller size in W-CG cell with a reduced spacing of CG to floating gate (FG) can obtain a higher coupling ratio and increase programming/erasing window owing to its novel lateral metal-insulator-poly coupling structure.
|
2022-12-15T01:13:17.415Z
|
9,292,846 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/FOREST:2004093",
"MAG": "2048730793",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The shiny appearance of poplar tension wood was tested in order to detect and to quantify the amount of tension wood in nine cross-cut discs. These carefully sawn discs came from different poplar clones: I214, Melone Carlo (I-MC) and Luisa Avanzo, exhibiting different patterns of tension wood distribution. The relevancy of the results was verified by means of 80 thin sections, 15 $\mu$m thick and double stained with safranine and astra blue. Digital images of the discs and microscopic cuts were processed by image analysis to quantify the comparison. There was good agreement between both methods despite very different scales of observation. Eighty percent of the tension wood spots were detected by both methods and differences were mainly explained by human factors or inaccuracies in the macroscopic detection of small areas.
|
2022-12-18T23:44:30.915Z
|
9,028,052 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/hrt.73.6.571",
"MAG": "2135897962",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://heart.bmj.com/content/heartjnl/73/6/571.full.pdf"
}
|
OBJECTIVE--To evaluate the incidence of intraoperative and early postoperative complications (up to two months after implant) of endocardial permanent pacemaker insertion in all patients under-going a first implant at a referral centre. METHODS--Prospective evaluation of all endocardial pacemaker implantation procedures performed from April 1992 to January 1994 carried out by completion of standard audit form at implant. Patients' demographic data, medical history, details of pacemaker hardware used, and any complications were noted. Follow up information was also collected prospectively onto standard forms at pacemaker outpatient clinic. SETTING--United Kingdom tertiary referral cardiothoracic centre. PATIENTS--1088 consecutive patients underwent implantation of their first endocardial permanent pacemaker from April 1992 to January 1994. Implant and follow up data were available for 1059 (97.3%) patients at analysis. The median (range) age was 77 years (16-99); 51.2 % were male. RESULTS--Dual chamber units were implanted in 54.1% of patients, single chamber atrial in 5.2%, and ventricular in 40.7%. A temporary pacing lead was present at implant in 22.9% of patients. Most (93.6%) implants were performed via the subclavian vein. Immediate complications were rare: eight (0.8%) patients developed pneumothorax requiring medical treatment and 11 (1.0%) an insignificant pneumothorax. There was no significant difference in the pneumothorax rate for dual chamber (DDD) compared with single chamber systems. Arterial puncture without sequelae was documented in 2.7% of attempts at subclavian vein cannulation. A total of 35 patients (3.3%) required reoperation; the reoperation rate for dual chamber (3.5%) was similar to that for single chamber (3.1%) systems. Electrode displacement (n = 15, 1.4%) was the most common reason for reoperation. Atrial lead displacement (n = 10, 1.6% of atrial leads) was significantly more common than ventricular lead displacement (n = 5, 0.5% of ventricular leads, P = 0.047). There was no difference in electrode displacement rates for dual (1.6%) compared with single (1.2%) chamber systems. Pacemaker pocket infection led to reoperation in 10 patients (six dual, four single chamber, P = not significant) and was significantly more common in patients who had a temporary pacing lead in place at implant (2.9%) than in those who did not (0.4%, P = 0.0014). Five patients (0.5%) required reoperation for generator erosion (two dual, three single chamber, P = not significant). and a further five for drainage of haematoma or a serous fluid collection (three dual, two single chamber, P = not significant). Complications that did not require reoperation were also rare. Undersensing occurred in 10 patients (0.9%). Atrial undersensing (n = 8) was significantly more common than ventricular undersensing (n = 2, P = 0.017). All patients were successfully treated by reprogramming of sensitivity. Superficial wound infection was treated successfully with antibiotics in nine patients (six dual, three single chamber, P = not significant). Three patients with DDD generators developed sustained atrial fibrillation: two required reprogramming to VVI mode and one required cardioversion. CONCLUSIONS--Permanent pacing in a large tertiary referral centre with experienced operators carries a low risk. Infection rates are low, < 1% overall but significantly higher in patients who undergo temporary pacing before implantation. Lead displacement and undersensing are more likely to occur with atrial than ventricular leads. The overall complication rate for dual chamber pacing, however, is no higher than for single chamber pacing.
|
2022-12-21T10:14:32.586Z
|
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