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206,072,548 |
{
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"DOI": "10.1039/c7cc07800e",
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|
A core-shell structure of Ag-Cr dual cocatalyst loaded-Ga2O3 was found to significantly enhance the formation rate of CO and selectivity toward CO evolution for the photocatalytic conversion of CO2 where H2O is used as an electron donor.
|
2022-09-16T04:20:42.803Z
|
51,722,078 |
{
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"DOI": "10.18632/aging.101507",
"MAG": "2883881857",
"PubMedCentral": "6075436"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.18632/aging.101507"
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|
Although previous studies indicated that cumulus cells (CCs) accelerate oocyte aging by releasing soluble factors, the factors have yet to be characterized. While demonstrating that CCs promoted oocyte aging by releasing soluble Fas ligand (sFasL), our recent study suggested that CCs might secrete other factors to mediate oocyte aging as well. This study tested whether CCs accelerate oocyte aging by secreting tumor necrosis factor (TNF)-α. The results showed that mouse CCs undergoing apoptosis released soluble TNF-α (sTNF-α) during in vitro aging. While ethanol activation rates were higher, the maturation-promoting factor (MPF) activity was lower significantly after culture of cumulus-denuded oocytes (DOs) in medium conditioned with CCs for 36 h than in medium conditioned for 24 h. Aging mouse oocytes expressed TNF-receptor 1. The CCs released equal amounts of sTNF-α and sFasL during aging in vitro, and the TNF-α-knockdown CCs secreted less sFasL than the control CCs did. Treatment of DOs in vitro with sTNF-α significantly accelerated their aging. The aging-promoting effect of sTNF-α was significantly reduced in TNF-α-knocked-down CCs and in CCs from the TNF-α-knockout mice. It is concluded that mouse CCs accelerate oocyte aging by secreting sTNF-α as well as sFasL.
|
2022-12-06T15:09:26.604Z
|
56,020,850 |
{
"externalids": {
"ACL": null,
"ArXiv": "1110.3937",
"DOI": "10.1051/0004-6361/201116776",
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},
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"status": "BRONZE",
"url": "https://www.aanda.org/articles/aa/pdf/2011/11/aa16776-11.pdf"
}
|
Aims. In the first few minutes of a newborn neutron star’s life the Hall effect and differential rotation may both be important. We demonstrate that these two ingredients are sufficient for generating a “shear-Hall instability” and for studying its excitation conditions, growth rates, and characteristic magnetic field patterns. Methods. We numerically solve the induction equation in a spherical shell, with a kinematically prescribed differential rotation profile Ω(s), where s is the cylindrical radius. The Hall term is linearized about an imposed uniform axial field. The linear stability of individual azimuthal modes, both axisymmetric and non-axisymmetric, is then investigated. Results. For the shear-Hall instability to occur, the axial field must be parallel to the rotation axis if Ω(s) decreases outward, whereas if Ω(s) increases outward it must be anti-parallel. The instability draws its energy from the differential rotation, and occurs on the short rotational timescale rather than on the much longer Hall timescale. It operates most efficiently if the Hall time is comparable to the diffusion time. Depending on the precise field strengths B0, either axisymmetric or non-axisymmetric modes may be the most unstable. Conclusions. Even if the differential rotation in newborn neutron stars is quenched within minutes, the shear-Hall instability may nevertheless amplify any seed magnetic fields by many orders of magnitude.
|
2022-12-14T13:20:31.324Z
|
1,686,190 |
{
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"ArXiv": null,
"DOI": "10.2214/AJR.11.7836",
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|
OBJECTIVE
The purpose of this study was to compare the differences in kinetic assessments of lesions at breast MRI performed with higher and lower temporal resolution.
MATERIALS AND METHODS
All consecutively evaluated BI-RADS category 4, 5, and 6 lesions imaged with breast MRI and pathologically confirmed from October 2005 to August 2009 were identified. Patients underwent MRI with one of two dynamic contrast-enhanced protocols: one with 90-second (October 2005-June 2006) and another with 180-second (July 2006-August 2009) temporal resolution. Studies were processed with a computer-aided evaluation system with initial and delayed contrast-enhanced time points with the k-space centered 90 and 450 seconds after contrast injection. Initial-phase peak enhancement, delayed-phase predominant curve type, and worst curve type were recorded and compared for benign and malignant lesions across protocols.
RESULTS
The analysis set comprised 993 lesions: 145 imaged with the 90-second acquisition (17 benign, 28 ductal carcinoma in situ [DCIS], 100 invasive cancer) and 848 imaged with the 180-second acquisition (212 benign, 145 DCIS, 491 invasive cancer). Peak enhancement was significantly higher for both benign lesions (p = 0.01) and invasive cancers (p = 0.0008) with the 180-second protocol. Peak enhancement of DCIS was similar in the two protocols (p = 0.88). Delayed-phase kinetics were similar for the two protocols for both benign and malignant lesions when defined by predominant or worst curve type.
CONCLUSION
Although it has lower temporal resolution, a 180-second acquisition may be preferable because it allows higher spatial resolution and captures higher initial-phase peak enhancement without loss of delayed-phase kinetic information.
|
2022-12-17T04:08:42.208Z
|
221,178,809 |
{
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"DOI": "10.1177/0014524620934075",
"MAG": "3067449996",
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"license": null,
"status": null,
"url": null
}
|
Bellinger is a well-known expert on the Psalms and tells us that ‘I have worked on the Psalms for decades and written about this beautiful text in various forms.’ (p. ix) His deep engagement with and love for the Psalter comes across in this mature, thoughtful and prayerful book. He cites John Calvin’s words that the Psalms are ‘the anatomy of all the parts of the human soul’ and opens with a brief history of the tradition of reading and praying the Psalms. In this book Bellinger suggests that the Psalms provide us with a ‘grammar of faith’, i.e a resource for faith, but even more, a language in which to express it so that it becomes a reality in itself. He notes that the psalms are used devotionally and yet they are rarely preached on – a resource needs to be ‘at the ready’ (p. 5) and so we need to preach and teach it regularly. The Psalms encompass the highs and lows of life and these texts need to be woven into the ‘warp and woof of our living’, says Bellinger (p. 5) Bellinger is steeped in a form-critical heritage of scholarship and deeply influenced by the idea of a final shape for the Psalter with its own movement towards a goal. He is interested in the literary patterns of psalms and their connection with worship (ancient and modern), also with their historical and thematic location within the Psalter, which in turn reveal meaning. Yet he is also concerned with their link to lived faith – ‘they get to the deep down stuff of faith’ (p. 12) – and ultimately meanings are linked to the readers make psalms their own ‘grammar of faith’. After an introductory chapter in which Psalms 6 (lament) and 8 (praise) are discussed, Bellinger turns to a second chapter on lament psalms and a third on psalms of praise with a detailed analysis of examples. In chapter 4 he airs the idea of ‘anthology’ – like a garden of flowers psalms are each flowers to enjoy and yet – to extend his image there is also a demonstrable beauty to arrangements of flower beds and to the whole garden. He stresses, though, that sequence is still important and that the shape of individual books (five in the Psalter) is crucial to understanding them, as is awareness of beginnings and endings and sequences within the texts and the shape of the whole. He posits that the crisis of the Israelite exile was a key shaping moment, but that theological themes of theodicy, protest and praise are heard throughout. Ultimately though ‘questions of genre are in the end readerand hearer-generated issues’ (p. 95). He lays a special emphasis on the role of book 5 of the Psalter in giving direction to the whole via its ‘multiple plots’. This is a successful mix of a resource for readers and congregations and an engagement with serious scholarship. It should be widely read and recommended.
|
2022-01-24T20:58:59.632Z
|
140,414,655 |
{
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"DOI": "10.1088/1674-4926/40/1/010203",
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"license": null,
"status": "BRONZE",
"url": "https://iopscience.iop.org/article/10.1088/1674-4926/40/1/010203/pdf"
}
|
Si is a promising photocathode material for photoelectrochemical (PEC) water splitting, while developing highly active non-precious catalysts and stable semiconductor/catalyst interface is critical to bring solar water splitting into reality. Recently, significant progress has been made in two-dimensional (2D) materials, e.g. transition metal dichalcogenides (TMDs), due to that their edge sites show highly catalytic activity for H2 evolution reaction (HER). To date, however, most of such studies have only been exploited as electrocatalysts for HER. Few works have achieved both efficient catalysis and stability when integrating TMD catalysts onto Si photocathodes for cheap PEC-HER. The Co-W-S/Ti/n+p-Si photocathode presented by Fan et al. reveals good PEC-HER performance and impressive operation durability for solar hydrogen production. An ultrathin and homogeneous Co–W–S catalyst layer was produced on Ti/n+ p-Si surface using a cheap wet chemical method, leading to more active sites for PEC reaction than pure WS2. Simultaneously, the inserted 5 nm Ti buffer layer played an essential role in protecting Si surface and reducing resistances of charge transfer on the electrode/electrolyte interface. An energy conversion efficiency of 4.0% were obtained under simulated AM1.5G illumination, along with a long-term stability for 6 days of continuous PEC reaction. Our findings emphasize the importance of effective loading of the catalyst and protective layer on the photoelectrode, which subsequently enables the PEC process both efficient and stable.
|
2022-07-31T09:12:10.190Z
|
225,557,076 |
{
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"DOI": "10.24310/riccafd.2020.v9i2.6706",
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"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://revistas.uma.es/index.php/riccafd/article/download/6706/9940"
}
|
espanolEl sedentarismo es un factor de riesgo cardiovascular de gran importancia, por lo que conociendo el nivel de consumo de oxigeno maximo (VO2max), se pueden realizar mejoras en los niveles de actividad fisica y del ejercicio. El objetivo de este estudio es determinar la relacion que existe entre la ergoespirometria y Queen’s College Step Test en hombres sanos y fisicamente activos de los programas deportivos de una universidad de Bogota – Colombia, debido a que el Queen’s College Step Test no ha sido validado en poblacion colombiana.Los participantes fueron 52 hombres (Rango edad 17-35 anos) a quienes se les realizaron cada una de las pruebas; se analizaron los resultados aplicando el coeficiente de correlacion de Spearman, el cual fue debil con un r=0.312; generando una correlacion poco significativa y una recomendacion desfavorable en esta poblacion. EnglishA sedentary lifestyle is a major cardiovascular risk factor, so knowing the level of maximum oxygen consumption (VO2max); you can make improvements in physical activity levels and exercise. The aim of this study is to determine the relationship between ergospirometry and Queen’s College Step Test in healthy and physically active men of the sports programs of a university in Bogota - Colombia, because the Queen’s College Step Test has not been validated in Colombian population. Participants were 52 men (range, age 17-35 years) who underwent each of the tests; the results were analyzed by applying the Pearson correlation coefficient, which was low with r = 0.278; generating a little significant correlation and an unfavorable recommendation in this population.
|
2022-07-27T11:55:56.549Z
|
146,330,716 |
{
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"DOI": "10.1017/S0953820800005537",
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"license": null,
"status": null,
"url": null
}
|
John Stuart Mill's connection with the Irish question spanned more than four decades and embraced a variety of elements. Of his writings on Ireland, the best known are his forty-three Morning Chronicle articles of 1846–47 composed in response to the Famine, the section of the Principles of Political Economy that treats the issue of cottier tenancy and the problem of Irish land, and, most conspicuous of all, his radical pamphlet England and Ireland, published in 1868. All of these writings take the land question as their paramount concern. The fairly absorbing interest in the subject disclosed by Mill during the second half of the 1840s arose from the fortuitous conjuncture of the disaster unfolding in Ireland and his engagement with the principles of political economy. Between 1848 and 1871 Mill's Principles went through seven editions (excluding the People's edition) and the substantive revisions he made in the section on Ireland from one edition to the next illumine both the essence and the accidentals of his bearing towards that country. Mill's cogent and controversial advocacy of fixity of tenure in England and Ireland constituted the heart of his answer to the Fenian challenge. The land question aside, Mill was drawn into the battle over the Irish university system in the 1860s largely through his friendship with John Elliot Cairnes, professor of jurisprudence and political economy at the Queen's College Galway. On this subject, however, Mill wrote almost nothing for publication. The longest single piece he ever drafted on Ireland was his first, an essay that predated the Morning Chronicle articles by two decades. In his own bibliography this essay is referred to as ‘An article on the Catholic Question which appeared in the Parliamentary Review for 1825’. Although the essay of 1825 could justly have borne the same title as the pamphlet of 1868, the particulars of course differ markedly. Ireland never ceased to pose a question during the course of the nineteenth century, but the dynamics shaping that question changed much between the mid-1820s and the late 1860s. Even so, the 1825 essay prefigures something of Mill's later involvement with the Irish question, and also invites examination as a quite remarkable piece of political journalism from the pen of a young man not yet twenty, who would subsequently establish himself as the most influential thinker of his generation.
|
2022-09-02T10:03:52.939Z
|
113,821,041 |
{
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"ArXiv": null,
"DOI": "10.20485/JSAEIJAE.6.4_127",
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|
: A model-based approach for the design and development of electrically heated catalyst (EHC) systems is presented. Based on experimental analysis of the EHC heat-up and catalytic behaviour, a detailed physico-chemical EHC model is developed. Within a total system simulation environment, different heat-up measures are compared for SULEV30 compliance. The simultaneous reduction of HC, NO x and GHG is revealed to be challenging, HC being the limiting factor for engine based thermal management. Regarding total energy consumption, a combined EHC and late PoI approach is favoured to meet emission limits. The developed operation strategy is presented in detail and confirmed by experimental findings.
|
2022-09-08T23:54:26.485Z
|
237,638,025 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fmed.2021.745279",
"MAG": null,
"PubMedCentral": "8502854"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fmed.2021.745279/pdf"
}
|
The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood. Diabetic kidney cells exhibit a cascade of mitochondrial dysfunction ranging from changes in mitochondrial morphology to significant alterations in mitochondrial biogenesis, biosynthetic, bioenergetics and production of reactive oxygen species (ROS). How these changes individually or in aggregate contribute to progression of DKD remain to be fully elucidated. Nevertheless, because of the remarkable progress in our basic understanding of the role of mitochondrial biology and its dysfunction in DKD, there is great excitement on future targeted therapies based on improving mitochondrial function in DKD. This review will highlight the latest advances in understanding the nature of mitochondria dysfunction and its role in progression of DKD, and the development of mitochondrial targets that could be potentially used to prevent its progression.
|
2022-11-18T09:45:39.319Z
|
229,512,702 |
{
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"ArXiv": null,
"DOI": "10.3390/geosciences10120477",
"MAG": "3106786990",
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},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2076-3263/10/12/477/pdf?version=1606213718"
}
|
Following environmental pollution exposure, calls to screen the population for disease or disease markers are often made. Population screening is a cross-sectional review of a population to find latent cases or biomarkers of disease that indicate the possibility of disease development; it differs from environmental screening or an epidemiological survey. Recognized standard approaches have been developed over 60 years to ensure quality and effectiveness in complex programs. We surveyed the literature for papers on health screening following environmental exposures and checked them for reference to accepted criteria such as those of Wilson and Jungner. We applied these criteria to three situations covering source/hazard (arsenic contaminated land), pathway/exposure (radiation release), and receptor/disease (lead poisoning). We identified 36 relevant papers. Although across the papers the whole range of criteria were addressed, no paper or program utilized recognized criteria. Issues and gaps identified included limited strategic approaches, lack of treatment, environmental prevention being seen as the screening outcome instead of treatment of identified individuals, and programs which did not fit the World Health Organization screening description. Robust discussion in the literature is needed to consider the organization and role of health screening following environmental exposures.
|
2022-12-02T12:05:13.879Z
|
99,161,588 |
{
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"ArXiv": null,
"DOI": "10.1039/C6QO00756B",
"MAG": "2593411549",
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},
"license": null,
"status": null,
"url": null
}
|
Transition metal-free oxidative coupling of vinyl azides with sulfonyl hydrazines is described. This radical process realized oxidative multi-functionalization of vinyl azides in the presence of potassium iodide and t-butyl hydroperoxide, selectively yielding β-keto sulfones and α-halo-β-keto sulfones in good to excellent yields with a wide tolerance of functional groups.
|
2022-12-03T22:52:00.748Z
|
191,602,594 |
{
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"DOI": "10.1109/TLA.2018.8804266",
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"url": null
}
|
Las redes moviles ad hoc han sido concebidas para operar como redes independientes, lo cual significa que la transmision de datos esta limitada a los nodos que conforman la red. Sin embargo, la mayoria de las aplicaciones moviles necesitan acceder a hosts (e.g. video servers ) ubicados en redes cableadas mas alla de los limites de la red movil ad hoc . Por lo tanto, los protocolos de enrutamiento que fueron originalmente disenados para operar en un ambiente ad hoc , deben ser optimizados para proveer interoperabilidad con otro tipo de redes. En este trabajo se presenta la integracion de un nuevo algoritmo al protocolo de enrutamiento AQA-AODV, con el fin de proveer conectividad entre las redes moviles ad hoc y las redes cableadas (redes heterogeneas). Este algoritmo ha sido disenado con el fin de mejorar las condiciones de red para la transmision de video sobre redes heterogeneas. Por lo tanto, se realizo una evaluacion de la solucion propuesta a traves de la simulacion de un escenario de red en el cual se transmiten videos de diferentes caracteristicas espacio – temporales. Los resultados demuestran que la solucion propuesta previene la congestion de la red, reduciendo las perdidas de paquetes y mejorando la calidad de los videos recibidos.
|
2022-12-15T02:08:44.039Z
|
158,362,857 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/23738871.2018.1556720",
"MAG": "2904127145",
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},
"license": null,
"status": null,
"url": null
}
|
ABSTRACTThis article examines the development of China's cybersecurity industry over the past two decades since the arrival of the internet in that country. This analysis takes place from a primarily security and technology perspective because the national security apparatus occupies a powerful presence in China's cyber affairs. Moreover, the development of the cybersecurity industry is significantly driven by the development of technological capabilities. Key issues explored include: (1) Chinese decision-making and thinking on cybersecurity development within the context of the Chinese leadership's general approach to development, national security, and technology advancement; (2) the nature and characteristics of recent Chinese cybersecurity-related development strategies and plans; (3) the drivers behind the development of China's cybersecurity industry, looking especially at market failures, national security rationales, and government intervention; (4) the proliferation of principal actors and coalit...
|
2022-12-16T17:00:28.404Z
|
153,655,917 |
{
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"ArXiv": null,
"DOI": "10.1080/02255189.2010.9669320",
"MAG": "1768806963",
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},
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"status": null,
"url": null
}
|
Abstract At the recommendation of the 1974 World Food Conference, the UN World Food Council (WFC) was established by the UN General Assembly at the ministerial or plenipotentiary level following the worst world food crisis in modern history at the beginning of the 1970s. The WFC was charged with overseeing the follow-up of the conference's resolutions and coordinating the work of the concerned UN agencies relating to food production, nutrition, food security, food trade, and food aid. This is the first summarized and selective account of the work of the WFC until its demise in 1993. The reasons for the fall of this UN body are given as well as proposals for another body to fulfil its roles.
|
2022-12-18T04:45:47.803Z
|
8,056,821 |
{
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"ArXiv": null,
"DOI": "10.1124/jpet.104.076331",
"MAG": "2150988649",
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},
"license": null,
"status": null,
"url": null
}
|
An extract of the plant Coleus forskohlii has been used for centuries in Ayurvedic medicine to treat various diseases such as hypothyroidism, heart disease, and respiratory disorders. Additionally, complex herbal mixtures containing this extract are gaining popularity in United States for their putative “fat-burning” properties. The active ingredient in C. forskohlii extract is the diterpene compound forskolin. Forskolin is a widely used biochemical tool that activates adenyl cyclase, thereby increasing intracellular concentration of cAMP and thus activating the protein kinase A (PKA) signal transduction pathway. We show herein that both forskolin and its nonadenyl cyclase-activating analog 1,9 dideoxyforskolin induce CYP3A gene expression in primary hepatocytes by functioning as agonists of the pregnane X receptor (PXR). We show that activation of PKA signaling potentiates PXR-mediated induction of CYP3A gene expression in cultured hepatocytes and increases the strength of PXR-coactivator protein-protein interaction in cell-based assays. Kinase assays show that PXR can serve as a substrate for catalytically active PKA in vitro. Our data provide important insights into the molecular mechanism of both the PKA-dependent and -independent effects of forskolin on the expression of drug-metabolizing enzymes in liver. Finally, our data suggest that herbal therapy with C. forskohlii extract should be approached cautiously due to the potential for herb-drug interactions in patients on combination therapy.
|
2022-12-27T15:03:32.367Z
|
189,974,717 |
{
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"ArXiv": null,
"DOI": "10.3390/RS11111281",
"MAG": "2947240701",
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"license": null,
"status": null,
"url": null
}
|
When side-scan sonars collect data, sonar energy attenuation, the residual of time varying gain, beam patterns, angular responses, and sonar altitude variations occur, which lead to an uneven gray level in side-scan sonar images. Therefore, gray scale correction is needed before further processing of side-scan sonar images. In this paper, we introduce the causes of gray distortion in side-scan sonar images and the commonly used optical and side-scan sonar gray scale correction methods. As existing methods cannot effectively correct distortion, we propose a simple, yet effective gray scale correction method for side-scan sonar images based on Retinex given the characteristics of side-scan sonar images. Firstly, we smooth the original image and add a constant as an illumination map. Then, we divide the original image by the illumination map to produce the reflection map. Finally, we perform element-wise multiplication between the reflection map and a constant coefficient to produce the final enhanced image. Two different schemes are used to implement our algorithm. For gray scale correction of side-scan sonar images, the proposed method is more effective than the latest similar methods based on the Retinex theory, and the proposed method is faster. Experiments prove the validity of the proposed method.
|
2022-12-29T16:23:44.787Z
|
90,816,958 |
{
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"ArXiv": null,
"DOI": "10.3954/1523-5475-33.1.61",
"MAG": "2753767557",
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},
"license": null,
"status": null,
"url": null
}
|
Abstract Drosophila suzukii (Matsumura) (Diptera: Drosophilidae) is an invasive vinegar fly that attacks a large variety of soft fruits including wild blueberries in Maine. Wild blueberry fields in Maine are commonly surrounded by woodland edges that contain wild fruit. These edges are important refugia as they provide the fly with needed shade and moisture during the hottest parts of the day. The wild fruit in these wooded edges are also potential alternative hosts for D. suzukii. We surveyed wild fruit along blueberry fields to determine the types of fruit present and measured D. suzukii infestation levels in surveyed fruit. We also measured the number of adult D. suzukii along field edges and the level of infestation in the wild blueberry crop. Drosophila suzukii was found in nine out of seventeen surveyed wild fruit species along field edges. Our results suggest a correlation between wild fruit infestation levels and adult fly densities in the crop fields. Blueberry fields with higher levels of wild fruit infestation also showed higher levels of adult D. suzukii trap captures in the commercial blueberry fields. These wild fruit hosts may allow D. suzukii to increase its population abundance prior to moving into commercial blueberry fields.
|
2022-12-30T15:48:24.845Z
|
234,624,307 |
{
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"DOI": "10.47930/1980-685X.2020.1707",
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|
Este artigo constitui-se de uma revisão teórica e tem como objetivo fazer um resgate teórico e histórico, da busca pela profissionalização do trabalho docente e uma análise do contexto do trabalho docente na atualidade, bem como, os riscos da queda a condição de trabalhador precarizado. A partir da constatação de que nos dias atuais avança um paradigma econômico que vem retirar direitos e o controle sobre o processo de trabalho das mãos dos trabalhadores em geral, de forma a precarizar o trabalho atingindo também o trabalhador docente, buscamos estabelecer o marco teórico para compreender o trabalho docente com suporte no entendimento da categoria trabalho, caracterizando o trabalho docente a partir do resgate dos fundamentos que amparam a discussão da profissionalização do trabalhador docente. E, por fim, analisando o trabalho docente no contexto da precarização a luz das novas realidades do trabalho na sociedade do capital global. Abordando especificamente como a “Uberização” do trabalho, a Reforma Curricular do Ensino Médio e o Programa Escola sem Partido, tem impactado na configuração e na precarização do trabalho docente. Esses atuais contextos de políticas educacionais, têm levado a perda de controle sobre o conhecimento que ensina, sobre o processo de ensino, os controles de intensidade impostos, além da sobrecarga e perda da autonomia, que tem para, além da proletarização, levado o trabalhador docente as ordas do trabalho precário e a cada nova política agudizando cada vez mais este processo de precarização.
|
2022-01-27T08:43:15.967Z
|
38,224,515 |
{
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"DOI": "10.1300/J027v22n04_02",
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"url": null
}
|
Gaining input from people who use home and community based services is important for determining the usefulness of services and clarifying future direction. Many of the commonly used methods have drawbacks when gaining input from people served. The current paper describes a focus group process that has been used to gain input from people who use home and community based services. The focus group process included designing the focus groups, their implementation, and feedback to stakeholders. Insights are presented and have implications for home and community based administrators, providers, and health care specialists.
|
2022-02-12T06:39:18.077Z
|
29,505,813 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3233/978-1-60750-690-4-378",
"MAG": "1527175953",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper describes the first experiences in development and usage of an environment to support a community in collaborative modeling efforts in the area of Technology Enhanced Learning (TEL). With first priority, the domain of interest, the sub-domains and the relationships have to be modeled to have a common understanding and a shared model for the further work and exchange. While the work continues, the model, and the sub-domain models continue to evolve. The tool that is presented here supports the modeling, especially the discourse conducted on the models in the collaborating network. With the tool i) the model rationale can be made transparent, ii) reasoning and agreements on changes in the model or its elements are systematically recorded by issue iii) the semantic wiki functionalities enhance the analysis of the discussion and discussion tracks. With the help of the tool, the community has continuously an updated model version at hand. Community members can raise an issue whenever a change or enhancement in the model is seen necessary. The members can share their updated sub-domain models and model variants for discussion. The tool is called Discourse Tool, since a discursive process is induced for negotiating and decision making on the model issues.
|
2022-02-12T13:27:09.069Z
|
122,680,667 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/IPRA.2006.IME3",
"MAG": "2141058267",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A fourth order accurate finite-difference subsampling technique is newly developed to analyze the 3D nanoscale plasmonic waveguide, and its advantages in computational efficiency and accuracy are validated through comparison with several conventional techniques.
|
2022-02-09T19:00:11.791Z
|
181,804,912 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/21645515.2019.1608745",
"MAG": "2945905381",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/21645515.2019.1608745?needAccess=true"
}
|
Seasonal influenza vaccines are frequently reformulated, leading to specific challenges for continuous benefit/risk monitoring. In 2014, the European Medicines Agency started requiring annual enhan...
|
2022-08-25T06:24:25.729Z
|
120,998,109 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1949-8594.1944.TB06206.X",
"MAG": "1968473265",
"PubMedCentral": "8856337"
},
"license": null,
"status": null,
"url": null
}
|
Metric Prefixes Conversions between metric system units are straightforward because the system is based on powers of ten. For example, meters, centimeters, and millimeters are all metric units of length. There are 10 millimeters in 1 centimeter and 100 centimeters in 1 meter. Metric prefixes are used to distinguish between units of different size. These prefixes all derive from either Latin or Greek terms.
|
2022-09-15T14:39:52.582Z
|
247,170,732 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/jb.00079-22",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210971"
}
|
Many members of the phylum Firmicutes (Bacillota) are capable of producing endospores, which enhance the survival of important Gram-positive pathogens that cause such diseases as anthrax, botulism, colitis, gas gangrene, and tetanus. We show that the core set of sporulation genes, defined previously through genome comparisons of several bacilli and clostridia, is conserved in a wide variety of sporeformers from several distinct lineages of Firmicutes. ABSTRACT The current classification of the phylum Firmicutes (new name, Bacillota) features eight distinct classes, six of which include known spore-forming bacteria. In Bacillus subtilis, sporulation involves up to 500 genes, many of which do not have orthologs in other bacilli and/or clostridia. Previous studies identified about 60 sporulation genes of B. subtilis that were shared by all spore-forming members of the Firmicutes. These genes are referred to as the sporulation core or signature, although many of these are also found in genomes of nonsporeformers. Using an expanded set of 180 firmicute genomes from 160 genera, including 76 spore-forming species, we investigated the conservation of the sporulation genes, in particular seeking to identify lineages that lack some of the genes from the conserved sporulation core. The results of this analysis confirmed that many small acid-soluble spore proteins (SASPs), spore coat proteins, and germination proteins, which were previously characterized in bacilli, are missing in spore-forming members of Clostridia and other classes of Firmicutes. A particularly dramatic loss of sporulation genes was observed in the spore-forming members of the families Planococcaceae and Erysipelotrichaceae. Fifteen species from diverse lineages were found to carry skin (sigK-interrupting) elements of different sizes that all encoded SpoIVCA-like recombinases but did not share any other genes. Phylogenetic trees built from concatenated alignments of sporulation proteins and ribosomal proteins showed similar topology, indicating an early origin and subsequent vertical inheritance of the sporulation genes. IMPORTANCE Many members of the phylum Firmicutes (Bacillota) are capable of producing endospores, which enhance the survival of important Gram-positive pathogens that cause such diseases as anthrax, botulism, colitis, gas gangrene, and tetanus. We show that the core set of sporulation genes, defined previously through genome comparisons of several bacilli and clostridia, is conserved in a wide variety of sporeformers from several distinct lineages of Firmicutes. We also detected widespread loss of sporulation genes in many organisms, particularly within the families Planococcaceae and Erysipelotrichaceae. Members of these families, such as Lysinibacillus sphaericus and Clostridium innocuum, could be excellent model organisms for studying sporulation mechanisms, such as engulfment, formation of the spore coat, and spore germination.
|
2022-12-10T09:14:00.628Z
|
18,496,818 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/MWSCAS.2010.5548583",
"MAG": "2059282201",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Designers use Monte Carlo simulations to evaluate the impact of variability on circuits, but such simulations require prohibitive amounts of computation to characterize rare events. In this paper, we propose a method by which the long tail behavior of circuits can be modeled with a reasonable number of simulations. This technique is then applied to the problem of domino keeper sizing to determine the sizing necessary to ensure a reliable circuit. We find that to ensure reliability for a commercial 45 nm process, the width of the keeper must be 0.17 times the effective width of the pull-down stack. Such a wide keeper results in a delay penalty of 9.9% compared to a circuit with no keeper.
|
2022-12-14T07:25:06.390Z
|
234,977,644 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26180/5F291CA33253C",
"MAG": "3156483971",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This thesis explores alternative dispute resolution (ADR) teaching in Australian clinical legal education. In a university law clinic, clinical legal education teaches students the skills needed for legal practice. With ADR becoming increasingly dominant in Australian legal practice, clinic students need to become knowledgeable about ADR so as to better advise clients about cost effective options for resolving cases without resorting to litigation. This enhanced focus on ADR has a vital ancillary effect of advancing access to justice. This thesis makes recommendations about how dispute resolution teaching can be better incorporated into clinical legal education for enhanced access to justice.
|
2022-02-07T21:28:27.333Z
|
10,798,622 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/FAMPRA/14.6.455",
"MAG": "2156700814",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Genital chlamydial infection is the commonest curable sexually transmitted disease in the industrialized world. Little is known about how GPs manage this condition.
OBJECTIVES
We aimed to determine current knowledge concerning genital chlamydia among GPs and to establish how patients with this infection are managed in primary care.
METHODS
A confidential self-administered postal questionnaire survey was sent to all 494 GPs in one English health district (Leicestershire).
RESULTS
Completed questionnaires were returned by 290 GPs (a response rate of 59%). A much higher proportion of GPs had tested and/or treated female patients for chlamydia [70%, 95% confidence interval (CI) 64-75%] as opposed to male patients (20%, CI 15-25%). Female patients (70%, CI 64-75%) were also more likely to be managed in general practice than male patients (56%, CI 50-62%). A majority of GPs (66%, CI 60-72%) routinely used an appropriate method of testing for chlamydia although a high vaginal swab, an inappropriate method of testing, was used by a fifth of GPs (19%, CI 15-24%). A large number of different treatment regimes were used by GPs. The majority of GPs (85%, CI 79-89%) prescribed an appropriate antibiotic although few GPs (19%, CI 14-25%) specified a chlamydia treatment regime in accordance with accepted international guidelines with respect to drug, dosage and duration of therapy.
CONCLUSIONS
Female patients with known or suspected genital chlamydial infection are commonly managed in UK general practice. There is scope to improve the management of this infection in general practice.
|
2022-09-02T08:43:44.226Z
|
224,982,411 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.23977/JASV.2020.020102",
"MAG": "3087379133",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Chinese herbal medicine has attracted people's attention as an ideal substitute for antibiotic additives in livestock production, and the characteristics of medicinal forage grass with both medicinal and forage value is the future development direction of grassland agriculture. Plantain was introduced to Guizhou Province in 2011, and has gradually been applied and extended in grassland agriculture. In order to standardize the planting of plantain, this article gives suggestions on the technical aspects of building, management and utilization of plantain pasture in Guizhou area, which provides technical support for the green development of grassland agriculture in Guizhou Province.
|
2022-06-30T05:20:13.386Z
|
205,641,213 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/09540121.2010.538660",
"MAG": "2051391763",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc3125460?pdf=render"
}
|
Abstract Health services research consistently confirms the benefit of insurance coverage on the use of health services sought in the USA. However, few studies have simultaneously addressed the multitude of competing and unmet needs specifically among unstably housed persons. Moreover, few have accounted for the fact that hospitalization may lead to obtaining insurance coverage, rather than the other way around. This study used marginal structural models to determine the longitudinal impact of insurance coverage on the use of health services and antiretroviral therapy (ART) among HIV-positive unstably housed adults. The impact of insurance status on the use of health services and ART was adjusted for a broad range of confounders specific to this population. Among 330 HIV-positive study participants, both intermittent and continuous insurance coverage during the prior 3–12 months had strong and positive effects on the use of ambulatory care and ART, with stronger associations for continuous insurance coverage. Longer durations of continuous coverage were less robust in affecting emergency and inpatient care. Race and ethnicity had no significant influence on health services use in this low-income population when confounding due to competing needs was considered in adjusted analyses. Given that ambulatory care and ART are factors with substantial potential impact on the course of HIV disease, these data suggest that securing uninterrupted insurance coverage would result in large reductions in morbidity and mortality. Health care policy efforts aimed at increasing consistent insurance coverage in vulnerable populations are warranted.
|
2022-09-14T06:05:08.756Z
|
253,372,499 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fcomp.2022.931973",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fcomp.2022.931973/pdf"
}
|
As humans, we spend most of our lives inside human-built environments, such as homes, offices, and schools. In these built environments, humans co-create and share a collective awareness, social practices, and knowledge while computing machinery is designed to maintain the built environment and support our interactions. The effects of these technologically enriched built environments on humans are how our bodies adapt to the practices they promote and how these practices, in return, affect the built environment and the natural environment. This perspective paper uses inbodied interaction to frame the constant adaption of our bodies to our surrounding environment as an opportunity to inform the design of technology and its practices and offer a vision where humans, the built environment, and the natural environment coexist in a mutually beneficial relationship.
|
2022-11-11T08:12:50.187Z
|
253,178,950 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/cimb44110354",
"MAG": null,
"PubMedCentral": "9689449"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1467-3045/44/11/354/pdf?version=1666773116"
}
|
Polyphenols are valuable natural antioxidants present in our diet that likely mitigate aging effects, neurodegenerative conditions, and other diseases. However, because of their poor absorption in the gut and consequent low concentration in biological fluids (µM range), reservations about polyphenol antioxidant efficiency have been raised. In this review, it is shown that after scavenging superoxide radicals, coumarin, chalcone, and flavonoid polyphenols can reform themselves, becoming ready for additional cycles of scavenging, similar to the catalytic cycle in superoxide dismutase (SOD) action. The π-π interaction between one polyphenol ring and superoxide is associated with oxidation of the latter due to transfer of its unpaired electron to a polyphenolic aromatic ring, and consequent formation of a molecule of O2 (one product of SOD action). Mechanistically, it is very difficult to establish if this π-π interaction proceeds before or after the most common mode of scavenging superoxide, e.g., abstraction of an aromatic polyphenol H(hydroxyl), which then is used to form H2O2 (the other molecule produced by SOD action). At the end of this cycle of superoxide scavenging, 4-methyl-7,8-di-hydroxy-coumarin and the flavonoid galangin reform themselves. An alternative mechanistic pathway by galangin forms the η-(H2O2)-galangin-η-O2 complex that includes additional H2O2 and O2 molecules. Another mode of action is seen with the chalcone butein, in which the polyphenol system incorporates a molecule of O2, e.g., a η-O2-butein complex is formed, ready for additional scavenging. Of the several families of polyphenols analyzed in this review, only butein was able to circumvent an initial π-π interaction, directing the superoxide towards H(hydroxyl) in position 4, e.g., acting as a typical polyphenol scavenger of superoxide. This fact did not impede an additional superoxide to later react with the aromatic ring in π-π fashion. It is concluded that by mimicking SOD enzyme action, the low concentration of polyphenols in biological fluids is not a limiting factor for effective scavenging of superoxide.
|
2022-12-02T12:03:55.256Z
|
253,754,055 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25122/jml-2022-0182",
"MAG": null,
"PubMedCentral": "9675312"
},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675312"
}
|
Thrombophilia, where multiple genetic and acquired risk factors interact synergistically, are associated with thrombosis and pregnancy-related complications. Despite being studied profusely, an inconsistent association exists between thrombophilia and pregnancy complications. Between 2018 and 2020, ninety-three women with pregnancy complications were enrolled in the study. Twenty-five healthy pregnant women without pregnancy complications reported to the same hospital were also recruited as controls. Blood samples were tested for homocysteine, coagulation studies, and molecular diagnosis included FVL, PTH and MTHFR genes amplified using PCR strip assay (Vienna Lab Diagnostics, Austria). Other thrombophilia screening, including testing for AT, PC, and LA, were done by chromogenic assays (Dade Diagnostica, Munich, Germany). Homocysteine level was determined by fluorescence polarization immunoassay technology (Axsym, Abbot company, Germany). Overall, 29.03% of women with pregnancy complications had thrombophilia relative to 16% in the control group. However, the difference between the case and control groups did not reach a significant level (p=0.1175). Additionally, combined thrombophilia was more prevalent among cases (10.75%) than in the control group (4%). However, the difference did not reach statistical significance (p=0.1046). Our study demonstrated that the frequency of thrombophilia among healthy women was 16%, and among women with pregnancy-related complications, 29%. Relative to control, all measured thrombophilia markers were more frequent in women with pregnancy-related complications except for LA. Including all the studies on the Saudi population in a meta-analysis study could reveal more information about thrombophilia and pregnancy-related complications in our population.
|
2022-12-10T09:10:10.393Z
|
14,970,110 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/2339530.2339652",
"MAG": "1995609428",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Non-guaranteed display advertising (NGD) is a multi-billion dollar business that has been growing rapidly in recent years. Advertisers in NGD sell a large portion of their ad campaigns using performance dependent pricing models such as cost-per-click (CPC) and cost-per-action (CPA). An accurate prediction of the probability that users click on ads is a crucial task in NGD advertising because this value is required to compute the expected revenue. State-of-the-art prediction algorithms rely heavily on historical information collected for advertisers, users and publishers. Click prediction of new ads in the system is a challenging task due to the lack of such historical data. The objective of this paper is to mitigate this problem by integrating multimedia features extracted from display ads into the click prediction models. Multimedia features can help us capture the attractiveness of the ads with similar contents or aesthetics. In this paper we evaluate the use of numerous multimedia features (in addition to commonly used user, advertiser and publisher features) for the purposes of improving click prediction in ads with no history. We provide analytical results generated over billions of samples and demonstrate that adding multimedia features can significantly improve the accuracy of click prediction for new ads, compared to a state-of-the-art baseline model.
|
2022-12-20T18:02:54.882Z
|
72,599,722 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/089124395009002003",
"MAG": "2059457468",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This research provides a history of women's domestic duties in the care of the dead prior to its transformation into a male-dominated market activity. The author presents data on the position of importance women held in the premarket care of the dead as well as on the knowledge necessary to prepare the body for burial. Both the positions and the knowledge women held were later appropriated into the more “advanced” practices by the newly developing funeral industry in the mid-19th century; moreover, the position women held as “shrouding women” was largely unacknowledged by the emerging funeral industry.
|
2022-12-25T13:02:06.564Z
|
56,136,877 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3892/ol.2018.9645",
"MAG": "2898658736",
"PubMedCentral": "6313016"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://www.spandidos-publications.com/10.3892/ol.2018.9645/download"
}
|
Cisplatin (DDP)-based anticancer therapy is an important chemotherapeutic strategy for the treatment of colorectal cancer. However, its beneficial effect is largely compromised by adverse reactions, and more importantly, by the development of drug resistance. Therefore, it is crucial to determine the potential mechanism underlying the development of DDP resistance in colorectal cancer. Interleukin-17 (IL-17) is a proinflammatory cytokine that has been found to serve an important role in the host defense during cancer development. It has been suggested that IL-17 is key to promoting the development of resistance to DDP in several major types of cancer. However, the role of IL-17 in DDP resistance in colorectal cancer has not been extensively investigated. In the present study, it was observed that IL-17 was significantly upregulated in colorectal tumor samples, compared with the adjacent tissues. Furthermore, IL-17 was found to promote the viability of HCT116 colorectal cells treated with DDP, whilst blocking IL-17 signaling leading to HCT116 cell apoptosis. IL-17 was also shown to regulate the expression of several apoptosis-related proteins, including phosphorylated-protein kinase B (p-Akt), apoptosis regulator BAX (Bax), apoptosis regulator Bcl-2 (Bcl-2) and serine/threonine-protein kinase mTOR (mTOR). These findings indicated that IL-17 facilitates the development of DDP resistance in colorectal cancer by inhibiting cancer cell apoptosis through targeting p-Akt, Bax, Bcl-2 and mTOR. Overall, the findings of the present study suggest that a combination of DDP and an IL-17 inhibitor may prove to be a highly efficient strategy for colorectal cancer treatment.
|
2022-12-25T22:50:49.361Z
|
117,305,202 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/EN11040972",
"MAG": "2802838184",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The idea of damming the Congo River has persisted for decades. The Grand Inga project, of up to 42 GW power generation capacity, can only be justified as part of a regional energy master plan for Africa, to bridge the energy gap on the continent. Proponents of very large dams have often exaggerated potential multiple benefits of a mega dam, marginalise environmental concerns and neglect the true risk of such projects, in particular for the fragile economies of developing countries. Studies have reported the financial risks, cost overruns and schedule spills associated with very large dams. In addition, most of the dams in the region are poorly managed. Therefore, the type and scale of Grand Inga is not the solution for millions of not yet electrified people in Sub-Saharan Africa. In this research, scenarios are defined based on announced costs and expected costs. Cost escalations in the range from 5% to 100% for the Inga project in 2030 and 2040 are considered, as average cost overruns are typically at about 70% or higher for similar mega-dams. It was found that when the cost overrun for the Grand Inga project exceeds 35% and −5% for 2030 and 2040 assumptions, respectively, the project becomes economically non-beneficial. In all scenarios, Sub-Saharan Africa can mainly be powered by solar photovoltaics to cover the electricity demand and complemented by wind energy, supported by batteries. Hydropower and biomass-based electricity can serve as complementary resources. The grid frequency stability of the power system is analysed and discussed in the paper. Benefits of the Inga hydropower project have to be increasingly questioned, in particular due to the fast cost decline of solar photovoltaics and batteries.
|
2022-12-26T16:40:30.099Z
|
87,283,644 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/14620316.2014.11513115",
"MAG": "2322011289",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Summary The total amounts of N derived from 15N-urea in the organs of 18 newly-bearing “maiden” apple trees and in the soil were determined after 1-year of fertigation with 15N-urea by drip irrigation, scheduled at a soil matric potential of –50 kPa. Prior to this treatment, the 18 “maiden” apple trees had been fertigated with three concentrations of N for 3 years: 17 mg N l–1 (low), 34 mg N l–1 (medium), or 67 mg N l–1 (high), and the same rates of 15N were chosen for treatment comparisons over the following 1 year. The trees were fertiligated with an aqueous stock solution of 15N-labelled urea (1.5 atom % 15N), KH2PO4, and KCl by drip irrigation. The phosphorus (P) and potassium (K) concentrations were constant, and set at 17 mg l–1 and 34 mg l–1, respectively. The total irrigation volume applied per tree was 363 l for the low, 430 l for the medium, and 216 l for the high N treatment.The corresponding supplies of N per tree were 6.17, 14.62, and 14.47 g, respectively. The total amounts of urea-N absorbed per tree were 1.90 g for the low-N, 3.73 g for the medium-N, and 3.21 g for the high-N treatments, with the percentage of N recovery (30.8%, 25.5%, and 22.1%) decreasing with increasing N rate, while the N retained in the soil was 2.92 g (47.3%), 7.40 g (50.6%), and 8.35 g (55.7%), respectively. Fertiliser N contributed more to whole-tree N uptake at increasing rates of N than N uptake from the soil. The total recovery of 15N from each tree-soil system was 78.1% at the low, 76.1% at the medium, and 79.8% at the high N level, with an average of approx. 22.0% of N unaccounted-for. The total amounts of P and K taken up were 2.42 g tree–1 and 14.49 g tree–1 for the low-N, 2.47 g tree–1 and 15.33 g tree–1 for the medium-N, and 1.31 g tree–1 and 8.04 g tree–1 for the high-N treatments, respectively. Our results showed that an N concentration of 34 mg l–1 (medium) resulted in more productive and profitable trees, bearing more fruit of higher quality than the other two N treatments. This concentration of N also improved the development of new leaves and flowers during the early stages of growth in the following Spring.
|
2022-03-06T08:36:50.336Z
|
19,331,698 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1177/1098612X12449407",
"MAG": "1973609019",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A spayed 14-year-old female domestic shorthair cat presented with a squamous cell carcinoma of the nasal planum and was treated with intralesional chemotherapy. During nasal infiltrations with cisplatin mixed with the cat’s own serum, a new carcinomatous lesion developed at the medial canthus of the right eye, which was also treated using intralesional chemotherapy. Two months after the treatment course, the cat developed a new mass at the site of the eyelid chemotherapy, which was diagnosed as a soft tissue sarcoma. At the owner’s request, the tumour was marginally excised, but it recurred after 10 months. No lung or lymph node metastases were evident at the time of euthanasia. The histotype of the tumour, the coincidence with injections and the histological description make the hypothesis of an injection-site sarcoma likely. To the authors’ knowledge, this is the first case of an injection-site sarcoma at the site of a cisplatin injection.
|
2022-09-23T00:26:39.030Z
|
234,207,095 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/JESTPE.2020.3043126",
"MAG": "3118821258",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article presents a step-up switched-capacitor (SC) multilevel inverter (MLI) with reduced ripple power loss by employing a soft-charging technique and modular cell. SCMLI possesses many attractive features for high-frequency ac (HFAC) applications. With a two-phase alternating structure, the voltage ratings of the components in the proposed SCMLI are substantially reduced compared with the unfolding H-bridge-based topologies while preserving the features of voltage step-up and self-voltage balancing offered by the series-parallel SC method. This structure also enables higher operating frequency by extending the maximum charging duration of capacitors. By inserting a small resonant inductor, soft-charging is achieved in all SC units in the inverter which mitigates the ripple loss and electromagnetic interference issues existing in many SCMLIs. The soft-charging operation of the proposed inverter under staircase modulation is elucidated based on the theory of underdamped SC circuit. The mathematical analysis is validated by the simulation and experimental outcomes showing a dramatic reduction in the ripple power loss by employing the soft-charging technique. The technique is highly suitable for high-frequency power distribution.
|
2022-11-17T17:46:19.721Z
|
120,806,518 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1098/rspa.1996.0125",
"MAG": "2001984471",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the x-y-plane, there is a well-known example of an exact formula for a steady ideal fluid flow, that is symmetric in the x-axis, that contains a pair of vortices bounded by a single circle, and whose far-field approaches a uniform flow in the x-direction. The stream function in this case has the form ψ — y where ψ obeys the partial differential equation — Δψ = (ψ — y)+ for y> 0 while approaching 0 at infinity and vanishing on the x-axis. The present work proves a uniqueness theorem for this boundary-value problem, by using the consequences of the maximum principle to establish symmetry properties of its solutions. An isoperimetric property of the flow is also established.
|
2022-11-29T22:58:21.328Z
|
16,684,614 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1167/15.15.7",
"MAG": "2221481640",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.1167/15.15.7"
}
|
We examined short-term memory for sequences of visual stimuli embedded in varying multisensory contexts. In two experiments, subjects judged the structure of the visual sequences while disregarding concurrent, but task-irrelevant auditory sequences. Stimuli were eight-item sequences in which varying luminances and frequencies were presented concurrently and rapidly (at 8 Hz). Subjects judged whether the final four items in a visual sequence identically replicated the first four items. Luminances and frequencies in each sequence were either perceptually correlated (Congruent) or were unrelated to one another (Incongruent). Experiment 1 showed that, despite encouragement to ignore the auditory stream, subjects' categorization of visual sequences was strongly influenced by the accompanying auditory sequences. Moreover, this influence tracked the similarity between a stimulus's separate audio and visual sequences, demonstrating that task-irrelevant auditory sequences underwent a considerable degree of processing. Using a variant of Hebb's repetition design, Experiment 2 compared musically trained subjects and subjects who had little or no musical training on the same task as used in Experiment 1. Test sequences included some that intermittently and randomly recurred, which produced better performance than sequences that were generated anew for each trial. The auditory component of a recurring audiovisual sequence influenced musically trained subjects more than it did other subjects. This result demonstrates that stimulus-selective, task-irrelevant learning of sequences can occur even when such learning is an incidental by-product of the task being performed.
|
2022-12-16T12:49:55.445Z
|
524,303 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/0008-5472.CAN-17-0286",
"MAG": "2749012804",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
NOTCH signaling exerts essential roles in normal and malignant intestinal physiology and the homeostasis of cancer stem-like cells (CSC), but the basis for this latter role remains obscure. The signaling scaffold protein STRAP is upregulated in several cancers, where it promotes tumorigenicity and metastasis. Here we report a novel oncogenic function for STRAP in maintaining CSC subpopulations in a heterogeneous mixture by antagonizing formation of the chromatin modifier PRC2 and by epigenetically activating NOTCH signals in human colorectal cancer. Silencing STRAP sensitized colorectal cancer cells to chemotherapeutic drugs in vitro and in vivo STRAP depletion also contributed to a reduced stem-like phenotype of colorectal cancer cells, as indicated by reduced expression of the CSC signature and NOTCH signaling regulators in vitro and by diminished tumorigenesis in vivo Genes encoding some upstream activators of NOTCH were highly enriched for H3K27me3, which forms repressive chromatin domains upon STRAP silencing. Mechanistically, STRAP competitively disrupted association of the PRC2 subunits EZH2 and SUZ12, thereby inhibiting PRC2 assembly. Restoring the NOTCH pathway by lentiviral expression of NICD1 or HES1 in STRAP-depleted tumor cells reversed the CSC phenotype. In 90 colorectal cancer clinical specimens, a significant positive correlation was documented between the expression of STRAP and HES1. Overall, our findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer, with potential implications to improve treatment of this disease. Cancer Res; 77(20); 5464-78. ©2017 AACR.
|
2022-12-16T20:52:09.257Z
|
120,404,513 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.325890",
"MAG": "1993354047",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Electrodeposited hard gold with 0.6 at.% cobalt has a hardness about four times that of annealed bulk gold and this high hardness cannot be reproduced by standard metallurgical methods. By measuring the hardness for gold and gold alloys subjected to various quenching, annealing, and deformation processes, all common hardening mechanisms such as solution hardening, precipitation hardening, strain hardening, and ’’voids’’ hardening were eliminated as possible major hardening contributors with the exception of the grain size effect. Pure gold with grain sizes ranging from 200 A to 3 μm were prepared using sputtering deposition by varying the substrate temperature during deposition from 55 to 310 °C. Larger grain sizes from 5 to 200 μm were prepared by annealing cold‐drawn gold wire at 300–750 °C. The hardness versus grain diameter followed the Hall‐Petch relation up to a grain size of 0.1 μm. Beyond that, the hardness increased less rapidly. At the grain size of electrodeposited hard gold of 250–300 A, the s...
|
2022-12-20T19:50:51.131Z
|
254,687,515 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00806765.2022.2144696",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT When Uppsala University Library was formally founded in 1620 and 1621, the book depot of the Crown, previously located on Gråmunkeholmen (today’s Riddarholmen) in Stockholm, was donated there. This collection inter alia contained the confiscated library of a Swedish nobleman and remnants from medieval Swedish monastery libraries. As Otto Walde conclusively proved in 1915, it also contained the Swedish parts of the library of the Swedish King Sigismund (Sigismund III in Poland), who was dethroned in Sweden in 1599. Sigismund’s books were soon scattered and spread among the rest of the book collections of Uppsala University Library, which were arranged according to subject, without any indication of provenance. The aim of the present article is to report what we currently know about Sigismund’s collection. Step by step, not least by the research of Otto Walde, but also by the ongoing work at the library, we are now able to know more titles and much more about the contents and destinies of this Royal book collection than what was previously known.
|
2022-12-17T21:49:01.747Z
|
74,811,720 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/01.bot.0000462964.48225.c0",
"MAG": "2313642368",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: We examined whether low-intensity pulsed ultrasound (LIPUS) whose frequency was reduced from the normal level to reach distal parts for long-reach can increase bone mineral density (BMD). Methods: Non-randomized controlled trial was conducted in elderly patients with osteoporosis living in the long-term care facility. LIPUS (oscillation frequency: 100 kHz) was used in the heel bone for 2 minutes a day for about 2 months. The speed of sound (SOS) at the heel bone was measured before and after treatment by the ultrasound bone densitometer CM-100. Results: In 19 women of the 30 participants, the SOS was obtained. The average SOS of the treated group (n = 11; average age, 75.2 years old) significantly increased from 1470.4 to 1487.0 within about 2 months of treatment (P = 0.002). The average SOS of the non-treated group (n = 8; 88.1 years old) was increased from 1448.9 to 1461.5 within about 2 months, but this did not reach the significance level (P = 0.124). In a subgroup of patients 80 years and older, the average SOS of the treated group (n = 7; 89.3 years old) significantly increased from 1448.5 to 1474.2 (P = 0.001), but the change in the non-treated group was not significant (from 1442.7 to 1450.9; P = 0.261). Discussion: This study suggests that using LIPUS with reduced frequency may increase BMD in the elderly with osteoporosis. Our results demonstrated the effect of LIPUS with reduced frequency on the heel bone, but it is necessary to confirm the effect influences on the femoral neck bone. Improvement of osteoporosis by LIPUS may be considered useful for the elder patients on multiple oral agents.
|
2022-02-11T07:56:12.707Z
|
188,214,537 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5151/2594-357x-25311",
"MAG": "2912580291",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://abmproceedings.com.br/ptbr/article/download-pdf/desenvolvimento-e-implantao-de-soluo-analtica-para-o-planejamento-otimizado-e-integrado-da-cadeia-de-redutores-da-csn"
}
|
In partnership with UniSoma, a company focused on analytical solutions development based on optimization, CSN has developed and implemented a tailor made computacional solution for the planning of its reductants supply chain. The solution consists of two basic modules - Embarque® and MIX®, which give support for the tactical and operational decisions regarding the solid fuels supply chain, ranging from the raw material acquisition until its consumption in the various steelmaking processes - Coke Plant, Blast Furnaces and Sinter Plant. Embarque® Module, tactical one, has a "computational intelligence" - in the form of a mathematical model - to solve in an integrated manner three related subproblems: the supply scheduling, the blending and production planning of various processes and the storage planning over time. The model is able to find a compromised solution between cost and quality objectives. The MIX ® Module, operational one, is used to define the blending scheduling in the short term, also through the use of an optimization math model. The paper presents not only the technical aspects of the solution as well the challenges faced during its implementation and the results realized since the beginning of its operation.
|
2022-06-12T14:07:17.862Z
|
244,003,083 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5070/k71151313",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://escholarship.org/content/qt7z56q9fr/qt7z56q9fr.pdf?t=r2cqa3"
}
|
This paper is a first approach to the kinship and social organization of the Ayquina-Turi Atacama Indigenous Community (El Loa Province, Antofagasta II Region) from the perspective of a genealogical inquest made in situ and in the city of Calama. The discussion unfolds in four stages: first, an introduction to the setting where the ethnographic inquiry was conducted; second, the presentation of the problem which inspired the research; third, the exposition of the baseline information; and fourth, the analysis thereof. In contrast to the current situation in other peasant indigenous communities in the Central and Southern Andes, it is possible to identify a strong tendency towards the conformation of matrifocal family units related to a generalized practice of intrafamily adoption, which finds ethnographic echoes reverberating in other places of South America, namely British Guiana.
|
2022-07-02T04:13:46.720Z
|
210,922,055 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0022050700059751",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
geoisie and nobility, burghers achieved recognition through the acquisition of lands and fiefs. The bourgeoisie was a seignorial bourgeoisie with a territorial fortune before becoming an officeholding bourgeoisie, allied to the nobility, with an administrative fortune. Between 1550 and 1665, a time of great social mobility, the bourgeoisie acquired much of the land of the old nobility and the commons and communal properties of many villages, as well as the holdings of individual peasants. Enterprising burghers succeeded in their ventures by undervaluing the properties that served their peasant and noble borrowers as collateral, by creating fictitious debts, and sometimes by resorting to force and threats. With its acquisition of extensive rural properties, the bourgeoisie created new servitudes. Contractual and temporary dues were transformed into customary and perpetual obligations. The real dues of the peasantry were augmented; the personal dues were retained. The new seigneurs simultaneously attempted to establish jurisdictional authority over the peasant and substituted dues in kind, including seignorial corvees, for the money dues that had been widely adopted at the end of medieval times. Obstacles were put in the way of social mobility; by the end of the seventeenth century society was rigidly stratified. The nobility was virtually transformed into a caste. Access to the ranks of the unennobled bourgeoisie from the peasantry and minor crafts was still possible but increasingly difficult. The new seigneurs, the "Junker" nobility of Burgundy, transformed their rural possessions after 1650 into compact domains known as rentes or granges, very similar to the jolvar\ of Poland and the Ukraine or the cijtli\ of the Ottoman Empire. This new type of manor, whether an agricultural exploitation attached to a village or, as was more customary, an isolated domain in the country, normally possessed two or more plows and a large number of cattle or draft animals. The peasant, on the other hand, had lost his cattle as he had his land and meadows to aggressive bourgeois proprietors and became increasingly dependent on rentes of this kind. In this manner he was transformed into a metayer, dependent on the capital of the possessor of a rente for his continued livelihood. In the eighteenth century, as metayage and indirect agricultural exploitation slowly gave way to commercial farming and direct agricultural exploitation, the peasant became a day laborer or hired worker.
|
2022-07-04T20:22:13.228Z
|
98,331,303 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1246/BCSJ.52.584",
"MAG": "2084426409",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
3-(2-Hydroxy-5-methylphenyl)-5-(p-methoxyphenyl)isoxazoline (HMPAO) is used for the simultaneous extraction and direct photometric determination of palladium. About 46 μg of palladium was quantitatively extracted at pH 1.0—2.0 with 10 ml of 1.0×10−3M HMPAO in isobutyl alcohol as a yellowish complex. It was measured spectrophotometrically at 332 nm, The system conformed to Beer’s law over the concentration range 1.0—20.0 μg of palladium per ml. The colour of the complex was stable for more than 48 h. Palladium was extracted quantitatively and was determined in the presence of large excess of ions which are associated with it. The extractable species was 1:2 (Pd: HMPAO) in nature. The equilibrium constants were determined according to the methods of Yatsimirskii and Leden with suitable modification.
|
2022-07-31T23:12:45.496Z
|
208,072,797 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/1475472X211005410",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The shooting method is commonly used to solve the linear parallel-flow stability problem for axisymmetric jets, i.e., a flow having one inhomogeneous direction. The present extension to two inhomogeneous directions – i.e., a bi-global stability problem – is motivated by inviscid non-axisymmetric jets. The azimuthal direction is Fourier transformed to obtain a set of coupled one-dimensional shooting problems that are solved by two-way integration from both radial boundaries – centreline and far field. The overall problem is formulated as one of iterative root-finding to match the solutions from the two integrations. The approach is validated against results from the well-established matrix method that discretizes the domain to obtain a matrix eigenvalue problem. We demonstrate very good agreement in two jet problems – an offset dual-stream jet, and a jet exiting from a nozzle with chevrons. A disadvantage of the shooting method is its sensitivity to the initial guess of the solution; however, this becomes an advantage when the need arises to track an eigensolution in a sweep over a problem parameter – say with increasing offset in the dual-stream jet, or with downstream distance from the nozzle exit. We demonstrate the performance of the shooting method in such tracking tasks.
|
2022-01-31T07:25:31.860Z
|
181,588,280 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24862/rcdu.v10i1.1013",
"MAG": "2946789446",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://periodicos.uniformg.edu.br:21011/ojs/index.php/cursodireitouniformg/article/view/1013/1083"
}
|
The present study aims to explore the relationship between the dogmatic conditions of the founding and the exclusion of international individual criminal responsibility. There are few cases in which an International Criminal Court has used previous international jurisprudence to establish a crime of conduct in international customary law, and in any case the importance of international judgments can not be underestimated as a general interpretative tool.
|
2022-04-01T01:34:48.959Z
|
248,535,954 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14746/aq.2021.32.1",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://pressto.amu.edu.pl/index.php/aq/article/download/32548/28263"
}
|
The text aims to describe currents, tendencies and fields of interest in design history studies in Poland, which grew in number around the year 2000. There are several characteristic patterns to be observed. First of all, despite the fact that the pioneering monograph on the subject appeared in 1978 (I. Huml), one can still observe terminological diversity, with various terms, such as applied arts and design, being used as synonyms. Secondly, looking at the history of the research, one may draw up a calendar of key events (publications, exhibitions) which led to the development and/or consolidation of the basic vision of Polish design from the end of the 19th century to the beginning of the 21st century, related primarily to the political and artistic history of the country. Thirdly, the increase in historical knowledge on the subject has been generated not only by different environments but also in the context of diverse institutions (academic and museum research, art market, collecting/connoisseurship). Consequently, the research conducted so far has been methodologically diversified, influenced by different goals and results. As a result, in the social reception there is a specific coexistence of projects of a scientific, popular science and commercial nature. A critical point in the dynamics of research was marked by two events which took place at the beginning of the 21st century: the exhibition Rzeczy pospolite and the subsequent publication (2000/2001), and founding of the quarterly “2+3D” (2001). Another marked increase in initiatives has occurred since the end of the 2000s. The demand for knowledge about design history is also, to some extent, animated by the art market. On the one hand, old design collecting generates a spontaneous exchange of messages on social media, while on the other, it stimulates the creation of reliable popular science studies. Research on Polish design has been dominated by the perspective of art history, usually in its traditional version focusing on style as well as the artistic and theoretical context, and highlighting issues of uniqueness and individual authorship, which prevail over functional, technological or social aspects in the discourse. Consequently, there has been no approach that would perceive Polish design and its multiple contexts as a dynamic system, a set of practices and mediations, such as the approach proposed several years ago by Grace Lees-Maffei (Production-Consumption-Mediation Paradigm) for design history. Such a perspective would enhance and stress the importance of research on the relations between various actors in the Polish design community, such as institutions (educational, experimental and research, manufacturing), transmitters (exhibitions, advice) and mediators between production and consumption.
|
2022-05-16T04:25:59.325Z
|
96,738,930 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00102208608923924",
"MAG": "2085802273",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Molecular beam mass spectrometry has been used to determine temperature and species concentrations in the discharge plume of a pulsed plasma jet igniter. Laser schlieren photographs of the plume/sampling cone interaction reveal that the molecular beam sampling has negligible effect on jet fluid mechanics up to the time of impingement, and temperature and species measurements indicate that at later times the gas is sampled from within the plume. The temperature in an atmospheric pressure jet of nitrogen ranged from a maximum of 50,000 K to ambient temperature. Peak nitrogen atom concentration at the detector was found to range from 5 percent. 2 mm from the igniter, to less than 100 ppm at 14 mm.
|
2022-08-06T16:54:38.768Z
|
71,483,351 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000169781",
"MAG": "1987344404",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
By simultaneously recording the carotid artery pressure, an electro-cardiographic lead and the chest phonocardiogram in the anesthetized dog, the effects of vasopressin on the systolic time intervals were observed. Vasopressin administered intravenously by bolus or infusion or subcutaneously produced a prolongation of the preejection period which was ascribed to a depressed rate of development of the myocardial contractile force and to a reduction in the stroke volume. It is suggested that the noninvasive measurement of the systolic time intervals in man may be used in monitoring patients under vasopressin treatment for gastrointestinal hemorrhage.
|
2022-09-11T00:51:16.055Z
|
205,952,614 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/c5cp02472b",
"MAG": "1890063945",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://pubs.rsc.org/en/content/articlepdf/2015/cp/c5cp02472b"
}
|
The disaccharide trehalose (TRH) strongly affects the physical properties of lipid bilayers. We investigate interactions between lipid membranes formed by 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and TRH using NMR spectroscopy and molecular dynamics (MD) computer simulations. We compare dipolar couplings derived from DMPC/TRH trajectories with those determined (i) experimentally in TRH using conventional high-resolution NMR in a weakly ordered solvent (bicelles), and (ii) by solid-state NMR in multilamellar vesicles (MLV) formed by DMPC. Analysis of the experimental and MD-derived couplings in DMPC indicated that the force field used in the simulations reasonably well describes the experimental results with the exception for the glycerol fragment that exhibits significant deviations. The signs of dipolar couplings, not available from the experiments on highly ordered systems, were determined from the trajectory analysis. The crucial step in the analysis of residual dipolar couplings (RDCs) in TRH determined in a bicelle-environment was access to the conformational distributions derived from the MD trajectory. Furthermore, the conformational behavior of TRH, investigated by J-couplings, in the ordered and isotropic phases is essentially identical, indicating that the general assumptions in the analyses of RDCs are well founded.
|
2022-09-12T05:55:54.722Z
|
41,674,850 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/49.539420",
"MAG": "2124170768",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We propose a closed-loop system for the acquisition of the pseudo-noise (PN) signal in direct-sequence spread-spectrum (DS/SS) systems. We introduce a novel idea of using an auxiliary signal, as opposed to the PN signal itself, for correlation with the incoming signal. The cross-correlation function of the auxiliary signal and the PN signal has a triangle shape that covers essentially the entire period of the PN signal. Consequently, their correlation provides the direction for the phase update of the local signal generator in the acquisition scheme. With coherent demodulation, the mean and variance of the acquisition time are derived under additive white Gaussian noise (AWGN). They are compared to those of the conventional serial-search acquisition system. Results suggest that the proposed system acquires the PN phase at least twice faster, with significantly smaller acquisition time variance, than the conventional system.
|
2022-09-13T05:01:49.913Z
|
28,622,852 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0181573",
"MAG": "2736349853",
"PubMedCentral": "5519183"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181573&type=printable"
}
|
WRKY transcription factors play pivotal roles in regulation of stress responses. This study identified 79 WRKY genes in potato (Solanum tuberosum). Based on multiple sequence alignment and phylogenetic relationships, WRKY genes were classified into three major groups. The majority of WRKY genes belonged to Group II (52 StWRKYs), Group III had 14 and Group I consisted of 13. The phylogenetic tree further classified Group II into five sub-groups. All StWRKY genes except StWRKY79 were mapped on potato chromosomes, with eight tandem duplication gene pairs and seven segmental duplication gene pairs found from StWRKY family genes. The expression analysis of 22 StWRKYs showed their differential expression levels under various stress conditions. Cis-element prediction showed that a large number of elements related to drought, heat and salicylic acid were present in the promotor regions of StWRKY genes. The expression analysis indicated that seven StWRKYs seemed to respond to stress (heat, drought and salinity) and salicylic acid treatment. These genes are candidates for abiotic stress signaling for further research.
|
2022-12-23T07:52:41.737Z
|
14,120,497 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fpls.2016.00287",
"MAG": "2302585305",
"PubMedCentral": "4786574"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fpls.2016.00287/pdf"
}
|
Quantitative real-time PCR (qPCR) is a popular and powerful tool used to understand the molecular mechanisms of flower development. However, the accuracy of this approach depends on the stability of reference genes. The capitulum of chrysanthemums is very special, which is consisting of ray florets and disc florets. There are obvious differences between the two types of florets in symmetry, gender, histological structure, and function. Furthermore, the ray florets have various shapes. The objective of present study was to identify the stable reference genes in Chrysanthemum morifolium and Chrysanthemum lavandulifolium during the process of flower development. In this study, nine candidate reference genes were selected and evaluated for their expression stability acrosssamples during the process of flower development, and their stability was validated by four different algorithms (Bestkeeper, NormFinder, GeNorm, and Ref-finder). SAND (SAND family protein) was found to be the most stably expressed gene in all samples or different tissues during the process of C. lavandulifolium development. Both SAND and PGK (phosphoglycerate kinase) performed most stable in Chinese large-flowered chrysanthemum cultivars, and PGK was the best in potted chrysanthemums. There were differences in best reference genes among varieties as the genetic background of them were complex. These studies provide guidance for selecting reference genes for analyzing the expression pattern of floral development genes in chrysanthemums.
|
2022-12-26T15:47:57.760Z
|
211,454,498 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1755-1315/351/1/012016",
"MAG": "2982344142",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1755-1315/351/1/012016"
}
|
Recently, the research on critical infrastructures have been extended its boundary and some previous research analysed interdependency between infrastructures tried to suggest operation and management policy of the infrastructure. This highlighted the importance of systemic approach such as System Dynamics. But there still exist the limit to select the modelling component in terms of causality. In this study, convergent cross mapping was applied to time series variables in Songpa-gu and Gangdong-gu in Seoul, South Korea. Selected variables include operating variable of water supply system, floating population and meteorological variables and 330 observations were collected. The result shows that daily average temperature and floating population that are equivalent to mobile population influences to the daily water supply, and vice versa. Other weather factors such as average precipitation and wind speed showed little causality with the daily water supply. The influential factors of water supply system can be investigated with convergent cross mapping and the result can be utilized for the pre-process of other methodology such as LSTM in short-term water demand prediction. It is expected to collect more available data to improve this study further.
|
2022-08-20T13:51:59.334Z
|
145,307,114 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/23323256.2014.940180",
"MAG": "2076931482",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The paper considers the place of the impersonal in the making of intimacies (in this case, the “mother-child dyad”), through examining examples of how temporality, grammar, measurement and knowledge are imbricated and naturalised in the events and processes of life-giving. Experimental in genre, the paper is expressive rather than rationalist, shifting between the personal voice and a more distanced analytic to unsettle taken-for-granted modes of scholarship and undo rigid distinctions between subjective and objective knowledge. Describing the interfaces and interleaving of embodied, intuitive and biomedical knowledge, I suggest that different modalities of knowledge, experience, intensity and duration weave together in the production of life, producing contradictions, contractions and expansions of the social world. Throughout, slightly tongue in cheek, I use the framing of “my culture” (a common South Africanism seldom used by English-speaking whites, who assume “culture” is elsewhere) to invite critical assessment and to reflect on the ways that individuals are uniquely positioned through socio-cultural practice. The refrain “I am the mother of two children” offers a heuristic through which to examine dyadic relations.
|
2022-09-13T16:41:57.935Z
|
145,049,163 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0192513X8100200202",
"MAG": "2117913182",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
THIS study investigated the relationship between multiple characteristics of women's jobs and their family adjustment in a sample of 99 women in dual-earner families. Six work-related variables were considered simultaneously as predictors of family adjustment: intrinsic job gratification, satisfaction with job security, job-related mood, time spent at work, occupational prestige, and salary. The results were consistent with the hypothesis that women's paid work lives influence their family adjustment. Women's experiences of their work were significantly related to two of three measures of family adjustment. Salary was negatively associated with satisfaction with family relations for women in low-status occupations only. Time spent at work and occupational prestige showed no significant associations with reported adjustment. Of the three indicators of family adjustment, marital satisfaction appeared to be relatively immune from work influences. We hypothesized that the marital relationship may be less sensitive to women's paid work than are other aspects of their family relations.
|
2022-09-15T08:34:02.554Z
|
126,014,590 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/CLEOPR.2018.TH1D.2",
"MAG": "2901841819",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Gradient echo memory is the most efficient quantum memory protocol to date. Recent additions of machine learning and compatible single photons can raise its performance and the possibility of using it as a quantum gate.
|
2022-01-27T03:17:56.393Z
|
137,018,582 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1520/STP12124S",
"MAG": "914442181",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
As steel cleanliness has been improved it has become ever more difficult to properly assess micro-inclusion contents and size distribution of harmful non-metallic inclusions in steel. The fact that inclusions do initiate fatigue is well known and easily proven in fatigue testing experiments. The problem addressed is to predict the occurrence of non-metallic inclusion of the size required to initiate fatigue failure in rotating beam samples based on modern high-resolution non-metallic inclusion assessments. The results of such non-metallic inclusion ratings are compared to the results obtained in fatigue tests of three modern, low total oxygen contents heats. These heats have been fatigue tested, and all fatigue initiations have been located to non-metallic inclusions which have been analyzed as regards to size, distance from specimen surface and inclusion chemical composition.
|
2022-10-03T16:39:04.521Z
|
191,165,858 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/19424280.2019.1604819",
"MAG": "2947905921",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Plantar pressure measurements, which present as bi-modal data, are used to examine how feet interact with different surfaces. Methods currently employed by researchers for comparing plantar pressure fail to describe the distribution of pressure over the entire foot. This study proposes the utilization of a novel metric, the Inverse Maximum Ratio (Λ’), that will allow researchers the ability to both quantify plantar pressure distribution using a single number, and utilize common methods of statistical hypothesis testing. Plantar pressure data from 17 subjects standing quiescently and using three under-foot conditions (bare foot, over-the-counter (OTC) insert under the foot, and customized foot insert (CFI) under the foot) were used to illustrate the utility of Λ’ in this context. The results observed were consistent with expectations, in that the null condition (bare feet) presented with greatest non-uniformity in plantar pressure distribution, while the CFI condition presented with greatest uniformity. Based on these results, we note that Λ’ can be used to expand upon current research that seeks to describe and compare the uniformity of plantar pressure distributions.
|
2022-12-15T03:21:11.319Z
|
35,177,923 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/IJE/18.SUPPLEMENT_1.S145",
"MAG": "2155057632",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Death rates from coronary heart disease (CHD) have been declining in Australia and New Zealand for 20 years. Data from the three MONICA Project Centres in Newcastle (Australia), Perth (Australia), and Auckland (New Zealand) show similar trends for fatal CHD but differing trends for non-fatal myocardial infarction (MI). In Auckland, there has been a consistent decline in out-of-hospital death rates but no decline in non-fatal MI rates. In Perth, the greater contribution to the overall decline has been from out-of-hospital deaths, but in-hospital death rates and non-fatal MI rates have also declined. There is also some evidence of an increase in survival following MI in Perth. In Newcastle, both death rates and non-fatal MI rates have declined. The limited data available suggest that at least one-half of the decline in mortality can be attributed to improvements in population risk-factor levels. Improvements in medical management of both risk factors and established disease are also making contributions to the decline.
|
2022-12-19T18:10:25.553Z
|
188,207,159 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5195/REVIBEROAMER.2019.7770",
"MAG": "3014579578",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
“ILUMINANDO A DURAS PENAS”: FORMAS DE VISUALIDAD MODERNA EN LA REVISTA URUGUAYO-ARGENTINA CARAS Y CARETAS ENTRE 1890 Y 1910
|
2022-12-19T10:21:25.143Z
|
40,382,255 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CDC.2006.377696",
"MAG": "2108751519",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A class of single-input single-output sigmoidal neural networks with nonlinear parametrization is considered. The problem of the continuous-time global exponential estimation of its parameters, both linearly and nonlinearly parametrized, is addressed. Under regularity assumptions on the neural network input trajectory, a novel solution to this problem is presented when the output, the input, and the input's derivative are available for measurement. The result is obtained showing that the sigmoidal neural network output coincides with the output of a suitable autonomous system of differential equations whose state and unknown parameters can be estimated with the tools of adaptive observation theory. If the sigmoidal neural network is the approximation of an arbitrary nonlinear mapping, the parameters estimates convergence is shown to be robust with respect to the neural network output approximation error
|
2022-02-12T04:32:28.519Z
|
34,709,110 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1142/S0129065701000679",
"MAG": "2160315892",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
CDMA and TDMA telecommunication techniques were established long time ago, but they have acquired a renewed presence due to the rapidly increasing mobile phones demand. In this paper, we are going to see they are suitable for neural nets, if we leave the concept "connection" between processing units and we adopt the concept "messages" exchanged between them. This may open the door to neural nets with a higher number of processing units and flexible configuration.
|
2022-02-12T09:05:53.790Z
|
3,053,678 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2514/6.2004-3446",
"MAG": "2321933909",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This paper presents preliminary results of ion sputter erosion characterization of carbon nanotubes. Relative erosion rates were compared by exposing multiwall carbon nanotubes (MWNTs), polycrystalline diamond films, amorphous carbon, and boron nitride to the exhaust plume of a 1.5-kW Hall-effect thruster operating on krypton propellant. Two types of MWNTs were investigated: films composed of vertically aligned tubes and those horizontally laid on the substrate surface. Only diamond films and vertically aligned MWNTs survived erosion by 250-eV krypton ions. The vertically aligned tubes were found to bundle at their tips into nanocones after ion erosion.
|
2022-02-13T13:01:28.901Z
|
85,756,205 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.16969/TEB.79961",
"MAG": "2222349962",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Turkiye’ de 1999-2011 yillari arasinda Brachycera grubuna bagli bazi sinek familyalarinin (Asilidae ve Bombylidae) faunasi uzerine yapilan calismalar esnasinda, Stratiomyidae familyasindan Oxycera cinsine ait uc tur tespit edilmistir. Tespit edilen Oxycera fallenii Staeger, 1844, Oxycera leonina (Panzer, 1798) ve Oxycera muscaria (Fabricus, 1794) turleri Turkiye faunasi icin ilk kez kaydedilmislerdir. O. fallenii ve O. leonina turlerine ait disi bireyler ile O. muscaria turune ait erkek bireyin karakteristik ozellikleri kisaca anlatilmis ve bu orneklere ait fotograflar sunulmustur. Bu uc turun yayilis alanlari kisaca tartisilmistir. Her turun Turkiye ve Palaearktik Bolgedeki biyocografik daglimi verilmistir.
|
2022-07-19T23:01:17.218Z
|
134,431,419 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21611/qirt.2018.p50",
"MAG": "2884302592",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.21611/qirt.2018.p50"
}
|
Internet of Things and Industrial Internet of Things begin its journey in several areas of our lives. Is a new wave of connectivity that is going beyond, desktop, tablet, smartphones, laptops or notebooks (internet of people). The goal to achieving is that things / objects become beings with a curiosity like humans and interconnected with each other. We do not know now how far the development will go. What we are sure is in this new digital era of hyper-connectivity the Infrared Industry: thermal imaging, InGaAs, thermal sensors, hyperspectral, there is much that can contribute.
|
2022-07-29T16:44:25.502Z
|
7,519,607 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1587/TRANSINF.E97.D.323",
"MAG": "2079898463",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A dual management of real-time and interactive jobs in dual-core smartphones is presented. The proposed scheme guarantees the end-to-end QoS of real-time applications, while also provides reasonable latency for interactive applications. To this end, high performance NVRAM is adopted as storage of real-time applications, and a dual purpose CPU scheduler, in which one core is exclusively used for real-time applications, is proposed. Experiments show that the proposed scheme reduces the deadline miss ratio of real-time applications by 92%. key words: real-time job, smartphone, NVRAM, scheduling
|
2022-12-11T07:50:47.904Z
|
83,717,353 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1084/JEM.125.4.579",
"MAG": "1981687332",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Antiviral factors present in cultures of rabbit peritoneal macrophages or rabbit kidney (RK) cells infected with Newcastle disease virus (NDV) and those in cultures of uninfected macrophages all fulfilled the biological and physicochemical criteria for classification as interferons. Virus-induced macrophage and RK interferons were slightly more stable to heat or acid than "spontaneously produced" or endotoxin-induced macrophage interferon. Interferon activity in serum of NDV-infected rabbits was decidedly more labile than NDV-induced macrophage interferon. However, these differences in lability were too slight to serve as a useful basis for distinguishing one rabbit interferon from another.
Rabbit interferons from various sources could be differentiated by filtration through Sephadex G-100 and their molecular weights estimated by comparison with elution profiles of a series of marker proteins of known molecular weight. Each of four different preparations of rabbit interferons was found to contain more than one molecular component. Elution peaks for three NDV-induced interferons were equivalent to the following molecular weights: RK ≃44,000–45,000 and > 134,000 (variable and 134,000 (variable and 134,000 (∼10% and heat labile). NDV-induced serum interferon may also contain another molecular component of mol wt ≃45,000 represented by a trailing shoulder from the major 51,000 mol wt peak.
Endotoxin-induced macrophage interferon proved to be polydisperse. Sephadex filtration of this interferon did not reveal clear and consistent elution patterns, partially owing to its low initial titer and lability. However, variable peaks of biological activity could be detected in Sephadex fractions equivalent to approximate molecular weight values of > 134,000, 72,000–78,000, 33,000–38,000, 28,000–30,000, and possibly a component of 42,000–45,000. A major component of mol wt ≃37,000 was present in all samples of endotoxin-induced macrophage interferon. The other constituents may be biologically active subunits or polymers.
These data indicate that rabbit macrophages produce two primary kinds of interferon: ( a ) an RK-like component of mol wt ≃45,000 that is synthesized in greatest amount after viral induction, and ( b ) a different species of mol wt ≃ 37,000 that can also be synthesized in the absence of viral induction. The presence of major interferon constituents of mol wt ≃51,000 and > 134,000 in rabbit serum after viral induction suggests that macrophages are not the principal interferon-producing cells that respond to intravenous injection of NDV.
|
2022-12-10T09:04:57.859Z
|
10,319,066 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/JNCI/64.2.383",
"MAG": "2101079996",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Specific-pathogen-free female F344 rats were exposed by inhalation to what was considered a maximal tolerated dose of cigarette smoke. Total pulmonary deposition of smoke particulates from a single cigarette was 0.25 mg in young rats. Rats were exposed to smoke from 7 cigarettes/day for as long as 2.5 years, at which time 30% of the rats remained alive. Mortality of smoke-exposed animals was not different from that of untreated or sham-exposed controls. Hyperplastic and metaplastic areas in the epithelium of the nasal turbinates, larynges, and tracheae of exposed animals were observed at death. The lungs of exposed rats contained areas of focal alveolitis consisting of accumulated pigmented macrophages, epithelial hyperplasia, fibrosis, and disrupted alveolar structure. Smoke exposure did not change the total number of tumor-bearing animals relative to controls; however, exposed rats had significantly fewer tumors in the hypophyses, hematopoietic-lymphoid systems, uteri, and ovaries but an increased number of tumors in the respiratory tracts and dermes. Only 1 of 93 (1%) control rats had a tumor (an alveologenic carcinoma) in the respiratory tract as opposed to 7 of 80 (9%) exposed animals (nasal tumors: 1 adenocarcinoma and 1 squamous cell carcinoma; pulmonary tumors: 5 adenomas, 2 alveologenic carcinomas, and 1 squamous carcinoma).
|
2022-12-19T06:40:42.605Z
|
97,415,930 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01614940.2014.946846",
"MAG": "2082952862",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Alkylbenzenes form an important segment of petrochemical industry for the manufacture of widely used commodities and specialty products. Since the last review on this topic (8), numerous new zeolite-based catalysts have been synthesized, characterized and evaluated in various transformations of aromatic hydrocarbons. This comprehensive review covers major reactions of mono-, di-, and tri-alkylbenzenes such as disproportionation, alkylation, transalkylation, isomerization, etc., over different zeolite-based acid catalysts. During the last decade, significant progress was made in the synthesis and structure determination of novel zeolites, mesoporous single crystals, hierarchic zeolites and two-dimensional zeolites. These developments have enhanced the understanding of the role of zeolites (effects of structural type, morphology, acid sites, accessibility of acid sites, shape selectivity factors) in transformations of aromatics. In this review, the emphasis is on the influence of the type of acid sites, zeolite topology, and reaction conditions on the activity, selectivity and pathways of these reactions. Thermodynamics and reaction kinetics of transformations of aromatic hydrocarbons are also discussed. This article covers mostly literature published during the period of 2002–2013.
|
2022-12-19T22:15:30.628Z
|
159,150,120 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.35903/TEANGA.V10I0.79",
"MAG": "2934560518",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Irish-medium naíscoil (pre-primary) sector is considered the foundation stone on which further sectoral developments at primary and post-primary level are initiated. This paper reports on research commissioned by the Department of Education in Northern Ireland on the educational outcomes of Irish-medium [IM] pre-school settings. The research was undertaken by RSM Mc ClureWatters (Consulting) and the author of this paper was project manager and lead author. The research explored which core components lead to optimum readiness for transition to IM primary school and the extent to which these components are present in IM naíscoileanna in the statutory and voluntary sector in the north of Ireland. The research methods were qualitative including a desk based legislative and policy analysis, a literature review and semi-structured interviews with school staff. Findings indicate that IM naíscoil practice is different from monolingual English-medium practice in a number of ways including transition practices. There are also differences between statutory and voluntary naíscoileanna. A number of recommendations are made in order to ameliorate differences in provision and associated inconsistencies in order to ensure equality in provision and the best outcomes and transition experiences possible for young Irish-medium learners.
|
2022-01-28T01:24:56.412Z
|
156,527,172 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1142/9789812775719_0026",
"MAG": "2477763142",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
AbstractThe following sections are included:The Money MarketMoney and IncomeThe Link from Money to IncomeMonetary PolicyEvaluation of Monetary PolicySummary
|
2022-02-09T00:44:16.441Z
|
144,700,596 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4000/RESS.2611",
"MAG": "2032528826",
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},
"license": null,
"status": null,
"url": null
}
|
Pareto a degage une loi importante avec sa courbe de distribution des revenus, dont il donne une interpretation essentiellement politique, notamment contre les socialistes soucieux de plus d’egalite. Dans ce texte, nous montrons qu’elle peut egalement etre consideree comme une piece importante de la sociologie economique, tant elle permet d’etudier ce qu’il se passe a la « pointe » de la distribution, ainsi que les travaux de Thomas Piketty le montrent.
|
2022-02-09T06:49:10.657Z
|
60,922,973 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/9780470744307.GAT052",
"MAG": "1557866621",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
There is a diverse array of information resources available for toxicological data. The primary scientific literature should perhaps form the basis of any robust search. This chapter describes some of the key bibliographic databases to this literature, such as the US National Library of Medicine's TOXLINE and MEDLINE files, as well as outlining some of the important factors that determine how effectively any search will find relevant data. Many useful compilations of hard toxicological data also exist, in the form of factual databanks or reviews produced by various expert groups. Many are available for free on the Internet. The Internet provides the interface with many of the key toxicological resources, as well as offering the opportunity for more general searches for data. The chapter concludes with a timely reminder about the importance of accuracy, data interpretation and verification of information when it comes to toxicology.
Keywords:
information retrieval;
databases;
databanks;
scientific literature;
searching;
online
|
2022-02-11T15:46:22.577Z
|
236,805,722 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31292/JTA.V3I3.127",
"MAG": "3093110449",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The provision of compensation for land acquisition for the construction of runway 3 at Soekarno-Hatta International Airport found problems that made the implementation of the development not complete according to the determined target. The research objective is to determine the implementation of compensation, the problems that occur and the solutions in solving them. This research uses qualitative methods with a descriptive approach. Research results: problems in the provision of compensation, namely differences in community understanding regarding deliberations to determine compensation, objections to the amount of compensation, parties who have the right not known their whereabouts, payment of separate compensation for land and buildings that have been consigned and disputes over ownership of land acquisition objects. The settlement of the problem of giving compensation is carried out by referring to the land acquisition law, while matters that are not regulated and/or incomplete in the regulation are resolved by the policy of the land acquisition executor.
|
2022-01-27T04:10:48.696Z
|
100,928,464 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1252/KAKORONBUNSHU1953.32.164",
"MAG": "2328912069",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
液柱塔において気液両相に拡散抵抗のある場合に対し。液側を平面拡散, カス側を円筒拡散として解析解 (Eq.(13).(14)) を得た. さらにその計算値と炭酸ガスの吸収 (CO2-N2-H2O), 亜硫酸ガスの吸収および放散 (SO2-N2-H2O), およびアンモニアの放散 (NH3-N2-H2O) の実測値と比較検討し, 両者は±10%以内で一致する事を認めた。
|
2022-05-31T06:58:09.823Z
|
143,084,651 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7253/PARTJ.V1I1.416",
"MAG": "1932538437",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Service-learning is an instructional method in which students learn course content by actively participating in thoughtfully organized service experiences related to the content. Effectively linking service-learning to course content not only offers students a powerful opportunity to maximize academic learning, but also promotes their personal growth and instills a commitment to lifelong, civic engagement. Service-learning was integrated into an upper level undergraduate course, Adolescent Development. In addition to completing the traditional course work, students also completed a service-learning experience at a community agency that served adolescents. In order to evaluate the effectiveness of the service-learning component, students were surveyed at the end of the semester about their service-learning experiences. Almost all students agreed they had learned more about course concepts as a result of their service-learning experience, and the majority felt their service-learning activity provided a needed service to the agency and community. KEYWORDS service-learning; assessment; pedagogy; civic engagement
|
2022-09-01T20:28:11.793Z
|
252,252,750 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2196/37905",
"MAG": null,
"PubMedCentral": "9597422"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://humanfactors.jmir.org/2022/4/e37905/PDF"
}
|
Background Outpatient pharmacy management aims for improved patient safety, improved quality of service, and cost reduction. The Six Sigma method improves quality by eliminating variability, with the goal of a nearly error-free process. Automation of pharmacy tasks potentially offers greater efficiency and safety. Objective The goal was to measure the impact that integration of automation made to service, safety and efficiency, staff reallocation and reorientation, and workflow in the outpatient pharmacy department. The Six Sigma problem definition to be resolved was as follows: The current system of outpatient dispensing denies quality to patients in terms of waiting time and contact time with pharmacy professionals, incorporates risks to the patient in terms of mislabeling of medications and the incomplete dispensing of prescriptions, and is potentially wasteful in terms of time and resources. Methods We described the process of introducing automation to a large outpatient pharmacy department in a university hospital. The Six Sigma approach was used as it focuses on continuous improvement and also produces a road map that integrates tracking and monitoring into its process. A review of activity in the outpatient department focused on non-value-added (NVA) pharmacist tasks, improving the patient experience and patient safety. Metrics to measure the impact of change were established, and a process map analysis with turnaround times (TATs) for each stage of service was created. Discrete events were selected for correction, improvement, or mitigation. From the review, the team selected key outcome metrics, including storage, picking and delivery dispensing rates, patient and prescription load per day, average packs and lines per prescription, and lines held. Our goal was total automation of stock management. We deployed 2 robotic dispensing units to feed 9 dispensing desks. The automated units were integrated with hospital information technology (HIT) that supports appointments, medication records, and prescriptions. Results Postautomation, the total patient time in the department, including the time interacting with the pharmacist for medication education and counseling, dropped from 17.093 to 11.812 digital minutes, with an appreciable increase in patient-pharmacist time. The percentage of incomplete prescriptions dispensed versus orders decreased from 3.0% to 1.83%. The dispensing error rate dropped from 1.00% to 0.24%. Assessed via a “basket” of medications, wastage cost was reduced by 83.9%. During implementation, it was found that NVA tasks that were replaced by automated processes were responsible for an extensive loss of pharmacist time. The productivity ratio postautomation was 1.26. Conclusions The Six Sigma methodology allowed for rapid transformation of the medication management process. The risk priority numbers (RPNs) for the “wrong patient-wrong medication error” reduced by a ratio of 5.25:1 and for “patient leaves unit with inadequate counseling” postautomation by 2.5:1. Automation allowed for ring-fencing of patient-pharmacist time. This time needs to be structured for optimal effectiveness.
|
2022-11-04T00:15:21.045Z
|
102,418,367 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5796/KOGYOBUTSURIKAGAKU.66.579",
"MAG": "2511451958",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Phosphate ion sensor system using an electr㏄hemical detector was developed by the use of r㏄ombinantpyruvate oxidase（PyOD）fromL㏄砂わω伽sρ㎞刎η2，which n㏄ds no addition of thiamine pyrophospha重e and flavin adenine dinudeodde for reaction・This syslemooulddetect2nMhydrogen peroxide。ResponseUmeforphosphateionwas80s and total measurement time for one sample was3min，Citrale buffer solution（pH6、3） was most sui似ble for the measurement and op廿mum flow rate was O．6mllmin．Under these optimum conditions，minimum detection limit of phosphate ion was15nM，which was enough for the detemlinationof phosphate ion in dam−lake．
|
2022-11-19T16:54:04.175Z
|
248,336,842 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/5.0090997",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://aip.scitation.org/doi/pdf/10.1063/5.0090997"
}
|
Strings of equally spaced particles, also called particle trains, have been employed in several applications, including flow cytometry and particle or cell encapsulation. Recently, the formation of particle trains in viscoelastic liquids has been demonstrated. However, only a few studies have focused on the topic, with several questions remaining unanswered. We here perform numerical simulations and experiments to elucidate the effect of the confinement ratio on the self-ordering dynamics of particles suspended in a viscoelastic liquid and flowing on the centerline of a microfluidic channel. For a fixed channel size, the particles self-order on shorter distances as the particle size increases due to the enhanced hydrodynamic interactions. At relatively low linear concentrations, the relative particle velocities scale with the fourth power of the confinement ratio when plotted as a function of the distance between the particle surfaces normalized by the channel diameter. As the linear concentration increases, the average interparticle spacing reduces and the scaling is lost, with an increasing probability to form strings of particles in contact. To reduce the number of aggregates, a microfluidic device made of an array of trapezoidal elements is fabricated and tested. The particle aggregates reduce down to 5% of the overall particle number, significantly enhancing the ordering efficiency. A good agreement between numerical simulations and experiments is found.
|
2022-12-09T07:54:36.042Z
|
108,966,878 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0887302X9601400402",
"MAG": "2005951082",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Major changes are occurring in higher education. Clothing and textiles programs with origins in home economics face many challenges as they move into the 21st century. The three purposes of this study were (1) to examine enrollment patterns, staffing and department configurations; (2) to ascertain the extent of departments' involvement in recruitment and enrichment or improvement activities, and perception of environmental conditions affecting programs; and (3) to test hypotheses concerning potential differences between large and small programs for recruitment, enrichment or improvement and environmental conditions. One questionnaire was mailed to the administrator of every department (234) with faculty who were members of the International Textile and Apparel Association (ITAA) in the United States, 160 administrators provided usable responses. Seventy percent of the administrators indicated their departments were multidisciplinary. Small programs, fewer than six faculty, constituted seventy percent of the sample used in the analysis. MANOVA and Hotelling's T2 procedures identified differences between large and small programs for recruitment (F(10, 119) = 1.86, p < .05), with large programs indicating greater recruitment activities. The other two hypotheses approached significance by program size for enrichment or improvement activities (F(10,128) = 1.71, p = .08) and perceptions of environmental conditions (F(12,119) = 1. 73, p = .07). Conclusions and implications focus on critical issues and concerns.
|
2022-12-10T18:15:52.003Z
|
25,394,421 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1006/CLIN.1996.0084",
"MAG": "1996106388",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Anti-La(SS-B) precipitin-negative sera show a restricted epitope recognition and can be easily overlooked in routine laboratory testing. We have therefore determined the prevalence of nonprecipitating anti-La(SS-B) antibodies in patients with primary Sjögren's syndrome and studied their clinical and immunological associations. Clinical details were obtained from 68 patients with primary Sjögren's syndrome, and serum samples were examined by enzyme-linked immunosorbent assay using purified recombinant La, 60-kDa Ro, and 52-kDa Ro proteins and by counterimmunoelectrophoresis. Thirteen patients (19%) were identified with anti-La antibodies which were nonprecipitating. These patients had similar clinical findings to other groups of patients with Sjogren's syndrome, but had significantly lower rheumatoid factor and serum IgG levels than patients with anti-La precipitins. None of the patients with nonprecipitating anti-La antibodies had previously contained anti-La precipitins in their sera. Furthermore, they tended to have lower levels of antibodies directed against denatured 60-kDa Ro (but not 52-kDa Ro) compared with anti-La precipitin-positive patients. Patients with Sjögren's syndrome associated with nonprecipitating anti-La antibodies represent a stable serological and clinical subset in which there appears to be limited diversification of the autoimmune response to the Ro60 and La proteins of the Ro/La ribonucleoprotein.
|
2022-12-20T13:00:23.240Z
|
32,104,732 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/area.12340",
"MAG": "2608416935",
"PubMedCentral": "5765837"
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://doi.org/10.1111/area.12340"
}
|
Activities utilising online tools are an increasingly visible part of our everyday lives, providing new subjects, objects and relationships – essentially new landscapes – for research, as well as new conceptual and methodological challenges for researchers. In parallel, calls for collaborative interdisciplinary, even transdisciplinary, research are increasing. Yet practical guidance and critical reflection on the challenges and opportunities of conducting collaborative research online, particularly in emergent areas, is limited. In response, this paper details what we term the ‘creative construction’ involved in a collaborative project building an exploratory database of more than 4000 food sharing activities in 100 cities that utilise internet and digital technologies in some way (ICT mediated for brevity) to pursue their goals. The research was undertaken by an international team of researchers, including geographers, which utilised a combination of reflexive coding and online collaboration to develop a system for exploring the practice and performance of ICT‐mediated food sharing in cities. This paper will unpack the black box of using the internet as a source of data about emergent practices and provide critical reflection on that highly negotiated and essentially handcrafted process. While the substance of the paper focuses on the under‐determined realm of food sharing, a site where it is claimed that ICT is transforming practices, the issues raised have resonance far beyond the specificities of this particular endeavour. While challenging, we argue that handcrafting systems for navigating emergent online data is vital, not least to render visible the complexities and contestations around definition, categorisation and translation.
|
2022-12-21T03:21:27.880Z
|
98,060,573 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00397910802026329",
"MAG": "2132360701",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract β-Hydroxy 1,2,3-triazoles from in situ generated 1,2-azidols were synthesized employing two sequential click reactions in very high yields with high regioselectivity using Cu(OAc)2·H2O as a catalyst in water at ambient temperature
|
2022-12-30T18:35:54.455Z
|
213,544,012 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.36959/357/453",
"MAG": "2997426121",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://scholars.direct//Articles/anatomy-and-physiology/sap-1-002.pdf?jid=anatomy-and-physiology"
}
|
Rudolf Virchow, considered by many the Father of Pathology, established a clear link between human and animal health. From that idea emerged the one medicine concept, which evolved into one health concept many years later. Nevertheless, only recently has there been a renewed interest in the subject, and this for three main reasons: i) The recognition that an extraordinary high percentage of infectious diseases in human were zoonosis; ii) The advances in the knowledge of the genome in man and animals; iii) The huge and rapid scientific progress achieved in recent years in the medical field.
|
2022-01-27T03:14:29.509Z
|
249,662,169 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7146/rvs.v1i.132826",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://tidsskrift.dk/rvs/article/download/132826/177938"
}
|
Artiklen diskuterer brugen af aksetids-teori hos Hans J. Lundager Jensen og John Milbank, samt dens relevans for dialogen mellem universitet og kirke.
|
2022-07-08T06:08:10.745Z
|
19,312,856 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/1097-0142(19800815)46:4<654::AID-CNCR2820460405>3.0.CO;2-A",
"MAG": "2014939181",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Five hundred and sixty‐six patients with either Stage III or IV Hodgkin's disease were prospectively randomized to test whether CCNU and/or vinblastine are more effective than mechlorethamine and/or vincristine with procarbarine and prednisone. The combination of CCNU, vinblastine, procarbazine, and prednisone (CVPP) was shown to be a highly effective program with a complete response frequency of 69%. The use of CCNU as part of the induction program was also shown to be the most significant determinant of prolonged remissions (P = .025). Reduced vomiting and neurotoxicity, as well as the oral administration, were the chief advantages of the CVPP as compared with MOPP. These factors resulted in improved patient and physician compliance. The MVPP regimen was also shown to be a highly effective regimen with a complete response frequency of 73% in patients without prior exposure to chemotherapy. However, the induction regimens containing vinblastine were associated with a significantly higher frequency of fatal hematopoietic toxicities than the induction regimens containing vincristine (P = .05). This higher frequency was almost exclusively seen in the elderly or in patients previously treated with both chemotherapy and radiotherapy. At this time, the remission durations maintained by vinblastine with periodic reinforcement are longer when compared with vinblastine maintenance alone (P = .06), but there is no corresponding increase in survival.
|
2022-09-13T07:04:58.006Z
|
16,881,282 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/MD.0000000000000464",
"MAG": "2086316803",
"PubMedCentral": "4602945"
},
"license": null,
"status": null,
"url": null
}
|
AbstractIron is essential for body homeostasis, but iron overload may lead to metabolic abnormalities and thus increase the risk for atherosclerosis and many other diseases. Major histocompatibility complex class I-like transmembrane protein (HFE) is involved in body iron metabolism. The gene coding for HFE has 3 well-known polymorphic sites of which H63D (rs1799945, C > G) has recently been associated with hypertension in a genome-wide association study (GWAS) study. In the present study, we wanted to clarify whether the genetic variant associates with hypertension in a Finnish cohort consisting of 50-year-old men and women.The study included 399 hypertensive cases and 751 controls from the Tampere adult population cardiovascular risk study (TAMRISK) cohort. Genotyping of polymorphisms was done by polymerase chain reaction using DNAs extracted from buccal swabs.We found that individuals with the mutated form of the H63D polymorphic site (G-allele) had a 1.4-fold risk (P = 0.037, 95% confidence interval [CI] 1.02–1.89) for hypertension at the age of 50 years compared with the CC genotype carriers. When obese subjects (body mass index > 30 kg/m2) were analyzed in their own group, the risk for hypertension was even stronger (odds ratio 4.15, P < 0.001, 95% CI 1.98–8.68). We also noticed that the blood pressure (BP) readings were higher in those with the minor G-allele when compared to ones having a normal genotype already at the age of 35 years. Means of systolic/diastolic BPs were 127/81 mm Hg for CC and 131/83 mm Hg for CG + GG groups (P < 0.001 for systolic and P = 0.005 for diastolic pressure).In conclusion, HFE genetic variant H63D was associated with essential hypertension in Finnish subjects from the TAMRISK cohort confirming a previous GWAS study. The effect of this SNP on BP was also confirmed from a longitudinal study.
|
2022-12-07T17:12:07.560Z
|
36,814,496 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PESS.2002.1043512",
"MAG": "2166122733",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the process of revising IEEE 519, "IEEE Recommended Practices and Requirements for Harmonic Control in Electric Power Systems", the P519 Working Group are reviewing all aspects of the Standard. This paper deals with Section 10.3 "Limits on Commutating Notches".
|
2022-12-08T23:54:04.384Z
|
33,823,089 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/106002809502900909",
"MAG": "2417216115",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: To report microsporidial keratoconjunctivitis in a patient infected with HIV who was treated with topical fumagillin. Case Summary: A 37-year-old white man who was experiencing redness, pain, irritation, decreased vision, and a foreign body sensation occurring in both eyes was referred to the ophthalmology clinic. The patient had a medical history significant for AIDS, Pneumocystis carinii pneumonia, and Cytomegalovirus retinitis. Conjunctival smears were taken and stained positive for the presence of Microsporidia. The patient was diagnosed with bilateral microsporidial keratoconjunctivitis and fumagillin therapy was initiated. After 5 days of therapy, the patient repotted significant improvements characterized by a decrease in blurred vision with only slight blurring in the left eye, decrease in headache, and decreased foreign body sensation. The patient continued topical fumagillin therapy for more than 14 months, with only slight blurring in the left eye and no apparent ocular toxicity as a result of fumagillin therapy. Discussion: Although rare in occurrence, increasing numbers of documented microsporidial infections are being reported in the medical literature, particularly in individuals who are seropositive for HIV. Clinicians need to be cognizant of microsporidial keratoconjunctivitis as another opportunistic infection in this patient population. Conclusions: Although a curative agent has yet to be discovered, fumagillin represents a safe, effective, low-cost, topical agent for the treatment of microsporidial keratoconjunctivitis.
|
2022-12-20T15:31:04.267Z
|
3,540,468 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/JAC.0000000000000189",
"MAG": "2594292331",
"PubMedCentral": "5338882"
},
"license": null,
"status": null,
"url": null
}
|
Despite some remarkable achievements, there are several challenges facing Brazil's Family Health Strategy (FHS), including expanding access to primary care and improving its quality. These concerns motivated the development of the National Program for Improving Primary Care Access and Quality (PMAQ). Although voluntary, the program now includes nearly 39 000 FHS teams in the country and has led to a near doubling of the federal investment in primary care in its first 2 rounds. In this article, we introduce the PMAQ and advance several recommendations to ensure that it continues to improve primary care access and quality in Brazil.
|
2022-12-20T14:34:50.825Z
|
120,546,473 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15388/BALTISTICA.7.2.1001",
"MAG": "1951336046",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ON THE ORIGIN OF THE PERSONAL PRONOUNS (mūs)-uje AND (mūs)-yje Summary In the article the author comes to the conclusion that the „plural“ form of the personal pronoun (mūs)-uje in the Lithuanian dialect of East Prussia is as old as that of the adessive (mūs)-upi. The forms in question seem to derive from the non-paradigmatic locativ *(mūs)-u. The forms of the reflexive pronoun, having the complementary distribution of „plural“ (but having no category of person), are, in some cases, substitutes for personal pronouns. This leads to the conclusion that the adessive ( mūs)-upi could have been replaced by ( mūs)-ipi, cf. savipi. Similar reasons may have caused the appearance of the inessive (mūs)-yje (cf. savyje); but its realization, at that time, became impossible as the contrast between the adessive and the inessive was neutralized. (In written records the adessive (mūs)-i(m)pi fulfils the function of the inessive). Only at the beginning of the 18th century when the necessity to unify the distinctive features of the inessive (i.e. to eliminate the contradiction between the identity and distinctive-features of the inessive) arose, was the adessive morpheme -i(m)p replaced by -yje which fitted best with the whole inessive system.
|
2022-02-09T22:15:41.303Z
|
51,664,066 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/T-AIEE.1930.5055484",
"MAG": "2067624948",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Part I of this paper describes the installation of two 20,000-kw., adjustable load, variable-ratio, frequency converters interconnecting the 25-cycle and the 60-cycle systems of the Niagara, Lockport and Ontario Power Company at Lockport Substation about twenty miles from Niagara Falls and Buffalo, N. Y. It also explains the function of the various machines, points out the more important features of the control, and relates a few interesting incidents in the past eighteen months of operation. Part II describes and explains the characteristics of such a converter and, more intimately, the operation and design of the component apparatus, using rather generally known and understood analogies, comparisons, and simple physical conceptions without any mathematical analyses or difficult theoretical treatment.
|
2022-02-11T22:51:06.675Z
|
72,178,478 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/BMJ.G6724",
"MAG": "2037182254",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
After qualifying James Ingram Watson accepted a post at Glasgow Royal Infirmary as houseman to Joe Wright, but he decided to have a year in general practice first. He spent a very happy year in Peebles, decided to stay in general practice, and took up an appointment in Perth in 1965, where …
|
2022-02-11T10:11:42.851Z
|
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