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29,578,255 |
{
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"DOI": "10.1258/ebm.2011.011053",
"MAG": "2333845182",
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"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4405537?pdf=render"
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|
Mutations in Pde6b lead to high levels of signaling molecules cyclic guanosine monophosphate (cGMP) and Ca2+, which ultimately result in photoreceptor cell death in certain forms of retinitis pigmentosa (RP). The level of cGMP, which is controlled by opposing activities of guanylate cyclase (GUCY) and photoreceptor phosphodiesterase-6 (PDE6), regulates the opening of cyclic nucleotide-gated ion channels [CNG] and thereby controls Ca2+ influx into the outer segments. Using a lentiviral gene therapy approach, we have previously shown that degeneration can be temporarily slowed either by introducing wild-type PDE6β or knocking down expression of GUCY2E and CNGA1 in photoreceptors of Pde6b H620Q , a mouse model for RP. Rescue was transient with either approach. Therefore, we tested a novel combination therapy using bipartite lentiviral vectors designed to both introduce wild-type PDE6β expression and knockdown GUCY2E or CNGA1. Immunoblot analysis shows simultaneous increases in PDE6β and decreases in GUCY2E or CNGA1 in retinas transduced by the vectors, indicating successful transduction. In Pde6b H620Q mutants, we observe rescue of photoreceptor function and an increase in photoreceptor rows as compared with untreated controls. However, no evidence of prolonged rescue beyond the limit of the previously tested single therapy was observed.
|
2022-12-10T09:09:41.754Z
|
23,668,805 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1107/S1600536813003164",
"MAG": "1585184863",
"PubMedCentral": "3588547"
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"status": null,
"url": null
}
|
Lanthanite-(Nd), ideally Nd2(CO3)3·8H2O [dineodymium(III) tricarbonate octahydrate], is a member of the lanthanite mineral group characterized by the general formula REE 2(CO3)3·8H2O, where REE is a 10-coordinated rare earth element. Based on single-crystal X-ray diffraction of a natural sample from Mitsukoshi, Hizen-cho, Karatsu City, Saga Prefecture, Japan, this study presents the first structure determination of lanthanite-(Nd). Its structure is very similar to that of other members of the lanthanite group. It is composed of infinite sheets made up of corner- and edge-sharing of two NdO10-polyhedra (both with site symmetry ..2) and two carbonate triangles (site symmetries ..2 and 1) parallel to the ab plane, and stacked perpendicular to c. These layers are linked to one another only through hydrogen bonding involving the water molecules.
|
2022-12-13T17:09:20.422Z
|
46,786,613 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000021703",
"MAG": "2003316849",
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},
"license": null,
"status": null,
"url": null
}
|
Using telemetered electromyography and immunocytochemical fibre typing (of both fresh frozen and preserved specimens), the present paper demonstrates clearly that at the elbow, knee, and ankle joints, the rhesus monkey (Macaca mulatta) is endowed with one extensor-muscle head specialized for posture. These postural heads are distinguished by (a) recruitment at low levels to maintain joint position against the effect of gravity, (b) recruitment near maximum levels during walking, and (c) high content and relatively large size of slow, fatigue-resistant (type I) muscle fibres. The nonpostural heads of the investigated muscles were recruited at levels correlated to the strenuousness of the effort and are notable by the small percentage and size of slow muscle fibres. The postmortem stability of the structural properties of myosin makes immunocytochemical fibre typing suitable for the study of preserved cadavers.
|
2022-12-21T09:46:55.513Z
|
204,834,419 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/biom9100625",
"MAG": "2981070749",
"PubMedCentral": "6843195"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2218-273X/9/10/625/pdf?version=1571390020"
}
|
The membrane translocation efficiency of cell penetrating peptides (CPPs) has been largely studied, and poly-arginines have been highlighted as particularly active CPPs, especially upon negatively charged membranes. Here we inquire about the influence of membrane mechanical properties in poly-arginine adsorption, penetration and translocation, as well as the subsequent effect on the host membrane. For this, we selected anionic membranes exhibiting different rigidity and fluidity, and exposed them to the nona-arginine KR9C. Three different membrane compositions were investigated, all of them having 50% of the anionic lipid 1,2-dioleoyl-sn-glycero-3-phospho-(1’-rac-glycerol) (DOPG), thus, ensuring a high affinity of the peptide for membrane surfaces. The remaining 50% was a saturated PC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC), an unsaturated PC (1,2-dioleoyl-sn-glycero-3-phosphocholine, DOPC) or a mixture of DOPC with cholesterol. Peptide-membrane interactions were studied using four complementary models for membranes: Langmuir monolayers, Large Unilamellar Vesicles, Black Lipid Membranes and Giant Unilamellar Vesicles. The patterns of interaction of KR9C varied within the different membrane compositions. The peptide strongly adsorbed on membranes with cholesterol, but did not incorporate or translocate them. KR9C stabilized phase segregation in DPPC/DOPG films and promoted vesicle rupture. DOPC/DOPG appeared like the better host for peptide translocation: KR9C adsorbed, inserted and translocated these membranes without breaking them, despite softening was observed.
|
2022-12-24T14:42:52.900Z
|
6,576,091 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IGARSS.1988.569468",
"MAG": "1524085304",
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},
"license": null,
"status": null,
"url": null
}
|
A simple procedure is used to provide relative calibration of a SIR-B multiple incidence angle data set, leading to backscatter dependence on incidence angle consistent with a double bounce interpretation of forest scattering. A backscatter model based on a dihedral comer reflector is shown to explain the calibrated SIR-B data.
|
2022-01-27T13:33:35.299Z
|
246,782,779 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4274/haseki.galenos.2022.7788",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.4274/haseki.galenos.2022.7788"
}
|
Ulnar variance is the relative length of the distal articular surface of the ulna to the radius (1). Ulnar variance measurement is generally performed in the neutral position using postero-anterior radiographs. However, the soft tissue resolution of radiographs is low. A recent study shows that ulnar variance on wrist magnetic resonance imaging (MRI) can be measured reliably (2). Another recent study shows positive ulnar variance increases pathologies of the triangular fibrocartilage complex (TFCC) and longitudinal carpal instability using MRI (3). A ganglion cyst is the most common benign soft tissue mass in the wrist. It is diagnosed based on imaging with sonography or MRI (4). Although the etiology of ganglion cysts remains unclear, the commonly accepted theory is that due to acute or chronic stress in the joint, the fluid in the joint leaks between the tissues, creating an inflammatory reaction (5). It is known that both negative and positive ulnar variances cause carpal instability (1). However, there is not sufficient information in the literature concerning the relationship between ulnar variance and ganglion cysts located in the wrist. This study aimed to evaluate the relationship between ulnar variance in the wrist and ganglion cysts in this region using 3-Tesla MRI.
|
2022-02-18T00:15:41.680Z
|
219,775,652 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1200/jco.2020.38.15_suppl.4626",
"MAG": "3032254825",
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},
"license": null,
"status": null,
"url": null
}
|
4626Background: In the Phase III POLO trial (NCT02184195), maintenance olaparib significantly prolonged PFS vs placebo in pts with a germline BRCA1 and/or BRCA2 mutation (gBRCAm) and mPaC (median 7...
|
2022-06-25T11:51:17.892Z
|
216,979,700 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22625/2072-6732-2017-9-4-14-23",
"MAG": "2783459605",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journal.niidi.ru/jofin/article/download/651/573"
}
|
Article is devoted to studying of the submitted epidemiological, clinical, tool, laboratory data on pathology of cardiovascular system at various viral infections. The review is based on results of domestic and foreign researches. At viral infections damage of heart and his carrying-out system perhaps as during the sharp period of a disease, and the period of a convalescence or at the chronic course of virus process. The greatest cardiothrogenism is possessed by enteroviruses, which affect the myocardium in 5–15% of cases. Much attention is paid to herpesviruses, widespread, persistently persistent in the body, as one of the reasons for the development of dilated cardiomyopathy, coronary vasculitis, early atherosclerosis, cardiac rhythm disturbance. Other infections that may affect the cardiovascular system include influenza viruses, adenovirus, poliovirus, Epstein-Barr virus, cytomegalovirus, human immunodeficiency virus, hepatitis, mumps, rubella, herpes simplex, varicella, arbovirus, respiratory-syntial virus, yellow fever virus et al. Complications from cardiovascular system can come to light at various age.
|
2022-09-12T04:06:17.926Z
|
25,647,385 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TEMC.2014.2384029",
"MAG": "2072286937",
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},
"license": null,
"status": null,
"url": null
}
|
This study assesses the lightning performance of 230- and 138-kV transmission lines under the assumptions of constant and frequency-dependent soil parameters. An electromagnetic model was used to simulate the response of tower-footing electrodes and overvoltages across insulators due to direct lightning strikes to the line, considering representative lightning current waveforms. Backflashover rates were determined using the Disruptive Effect Model. It was found that the decrease of soil resistivity and permittivity, resulting from the frequency-dependence effect, is responsible for significant decrease of the expected outage rate of the tested lines, in the range of 13-32% for usual distributions of soil resistivity along the lines.
|
2022-12-15T17:59:48.830Z
|
18,310,974 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/93.917973",
"MAG": "2084310563",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
We propose a method for constructing superstructure on the Web using XML and external annotations to Web documents. We have three approaches for annotating documents: linguistic, commentary, and multimedia. The result is annotated documents that computers can understand and process more easily, allowing content to reach a wider audience with minimal overhead.
|
2022-12-18T07:54:31.945Z
|
76,282,667 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2169/naika.67.409",
"MAG": "2318397786",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.jstage.jst.go.jp/article/naika1913/67/4/67_4_409/_pdf"
}
|
本邦では報告の少ないアレルギー性気管支肺アスペルギルス症の1例を報告する.患者は22才,男性,職業は農業.発作性の喘鳴,出没を繰り返す肺野の浸潤陰影,喀痰中および末梢血中好酸球増加,茶褐色の粘液栓の喀出が認められた.胸部X線像,気管支造影,気管支鏡によつて粘液詰め込み状態(mucoid impaction)にあることが証明された.また, IgE, IgGの増加,補体の低下か認められた.さらに,アスペルギルス抗原に対してI型(即時型)およびIII型(アルツス型)皮膚過敏反応,沈降抗体,補体結合性抗体が認められた.アスペルギルス抽出液の吸入試験でも早期(I型)および晩期(III型)の2相性の反応が認められた.喀出された茶褐色の粘液栓からアスペルギルスが培養された.治療後の気管支造影で,特徴的な近位気管支拡張症が認められた.すなわち,比較的太い気管支が紡錘状に拡張しており,その末梢は正常な造影所見であつた.
|
2022-07-10T22:33:26.387Z
|
145,944,697 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/NFS-02-2019-0049",
"MAG": "2938555377",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
PurposeRecent evidence suggests that especially processed foods may lead to undesirable metabolic effects in gut microbiota. The emulsifiers and artificial sweeteners that are added to processed foods may play a role in the progression of the diseases through the modulation of microbiota in mice. In this context, the purpose of this paper is to evaluate the effects of emulsifiers and artificial sweeteners.Design/methodology/approachThis paper presents a narrative review of the effects of emulsifiers and artificial sweeteners which are mainly in consumed in the Western diet, to the gut microbiota by mainly focusing on the experimental studies.FindingsAlthoughin vivostudies and animal model studies showed various adverse effects of sweeteners and emulsifiers to microbiota, studies should be conducted in humans to investigate the effects of these food additives to human microbiota by making dietary interventions in the context of ethical rules.Originality/valueIn future, studies will allow us to draw more definitive conclusion whether human population consuming sweeteners and emulsifiers are at risk.
|
2022-08-24T08:24:51.433Z
|
53,207,636 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/POWERAFRICA.2018.8520979",
"MAG": "2900236661",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper develops a new mathematical optimization model for effective scheduling of optimal power generated from offshore wind farms with proper consideration to harmonic losses and locational marginal prices minimization, and this model is a function of harmonics resulting from large penetration of offshore wind power into the grid. Harmonics is obtained from modeling and simulation of offshore wind farms on the grid using Electrical Transient Analyzer Program (ETAP 12.6.0) power station software. An IEEE six Garver bus system is used to test the efficiency of the proposed model and the simulation results reveal that the increase of harmonic power losses causes increase in nodal marginal prices.
|
2022-08-28T02:53:10.217Z
|
140,632,028 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/92TC01831",
"MAG": "2032079420",
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},
"license": null,
"status": null,
"url": null
}
|
A perplexing variety of crustal models have been proposed for the region beneath the southern Appalachian overthrust. Determining the true nature of crustal composition and structure in this region carries important scientific and economic implications. To evaluate the numerous models, compressional wave velocities and densities were measured on 30 rock samples collected within the Grandfather Mountain window in the Blue Ridge of North Carolina. The window breaches high-grade crystalline rocks, exposing Grenville gneisses, Late Proterozoic metasedimentary and metavolcanic rock, and Cambrian quartzite, phyllite, and dolostone that are likely to underlie the regional Blue Ridge-Piedmont thrust. Measured velocities range widely from 4.21 km s−1 for Cambrian phyllite to 7.47 km s−1 for tectonized Cambrian Shady Dolomite at 200 MPa. Velocity anisotropy is as great as 47% in the phyllite. The samples exhibit a broad range in densities as well: from 2500 kg m−3 in fractured quartzite to 3000 kg m−3 in metabasalts. Synthetic reflection seismograms were generated using these physical properties to consider the origin of subthrust reflection events. In addition to the much-publicized interpretation of Paleozoic sedimentary rocks residing beneath the crystalline sheet, modeling reveals that the reflections could also be explained by metamorphosed Paleozoic strata, by the regional Late Proterozoic metavolcanic and metaclastic rift sequence, and by pervasive shear zones (i.e., mylonites) within compositionally homogeneous gneisses. We interpret field data to strongly favor mylonitic gneisses as the subthrust reflectors. Still, surface data remain sufficiently ambiguous that the question will not be definitively settled without continental drilling.
|
2022-09-18T15:33:26.316Z
|
24,901,749 |
{
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"ArXiv": null,
"DOI": "10.1203/00006450-198801000-00184",
"MAG": "2086481347",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.nature.com/articles/pr1988184.pdf"
}
|
T 3-4 weeks after an i.m. dose of T, many of our HH patients deny a decline in sexuality so soon. To evaluate the effects of T replacement, 9 patients with HH, 18-30 years of age, were studied. Following an i.m. dose of 250 ng T propionate/enanthate they were studied at the 2nd, 4th, 6th and 8 weeks, then received a placebo dose and were reevaluated 1 week later. At each overnight study, they underwent a set of penile tumescence (PT) recordings during a pornographic film and slides, self-induced erotic fantasy and nocturnal PT, as well as self-report of a 10-point questionnaire. Results were compared to those of 10 volunteers. Serum T declined to subnormal levels by the 4th week. On the self-report, sexual drive and fantasies were comparable to controls, but rating of sexual relations, erection time and ejaculations were significantly lower (p<0.01). Self-rating of erection strength showed a gradual decline (p<0.05) and became subnormal by the 8th week. Nocturnal PT and erotic-response PT were normal throughout the 9 weeks of the study and did not drop to subnormal values. It is concluded that the stimulatory effects of T replacement in HH involve mainly libido factors and extend beyond the period of normal serum T. Therapy must be evaluated by these criteria and can be administered bimonthly.
|
2022-02-12T18:25:58.677Z
|
492,499 |
{
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"ArXiv": null,
"DOI": "10.1371/journal.pone.0062813",
"MAG": "1985803955",
"PubMedCentral": "3652831"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062813&type=printable"
}
|
Animal home ranges may vary little in their size and location in the short term but nevertheless show more variability in the long term. We evaluated the degree of site fidelity of two groups of spider monkeys (Ateles geoffroyi) over a 10- and 13-year period, respectively, in the northeastern Yucatan peninsula, Mexico. We used the Local Convex Hull method to estimate yearly home ranges and core areas (defined as the 60% probability contour) for the two groups. Home ranges varied from 7.7 to 49.6 ha and core areas varied from 3.1 to 9.2 ha. We evaluated the degree of site fidelity by quantifying the number of years in which different areas were used as either home ranges or core areas. Large tracts were used only as home ranges and only for a few years, whereas small areas were used as either core area or home range for the duration of the study. The sum of the yearly core areas coincided partially with the yearly home ranges, indicating that home ranges contain areas used intermittently. Home ranges, and especially core areas, contained a higher proportion of mature forest than the larger study site as a whole. Across years and only in one group, the size of core areas was positively correlated with the proportion of adult males in the group, while the size of home ranges was positively correlated with both the proportion of males and the number of tree species included in the diet. Our findings suggest that spider monkey home ranges are the result of a combination of long-term site fidelity and year-to-year use variation to enable exploration of new resources.
|
2022-12-13T02:50:57.806Z
|
28,890,236 |
{
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"DOI": "10.1109/51.982281",
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|
A time-frequency approach using wavelets to study movements at different angular velocities is considered. The authors summarized the application of the continuous wavelet transform (CWT) to the analysis of the surface myoelectric (ME) signal. The present technique of determining MNF has the advantage that it is possible to determine the frequency content of the ME signal during short and nonstationary contractions. In addition, the CWT method is very reliable for the analysis of nonstationary biological signals and does not require any smoothing function as do methods based on Wigner-Ville. However, using time-frequency methods involves two main tradeoffs: i.e., potential increases in performance for a given application versus computational complexity and storage requirements. Our results confirmed earlier studies that MNF is independent of angular velocity.
|
2022-12-19T18:02:56.957Z
|
84,297,233 |
{
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"ArXiv": null,
"DOI": "10.3199/ISCB.1.1",
"MAG": "2039767577",
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}
|
Chrysanthemum zawadskii showed 2n=54 (hexaploid chromosme number) and extensive variation in the color of the ligules (from white to pinkish). FISH yellow colored signals of the 5S, 45S rDNA and telomeres were obtained after hybridized of the biotin labeled of the 5S rDNA, pTa71 and telomeric sequence repeats probes to somatic chromosomes. They showed 5-6 interstitial and two terminal signals at the 5S rDNA region, 10-14 terminal and 4-5 interstitial signals at the 45S rDNA region and the telomeric signals at the region of telomeric sequence repeats on both chromosome arms in the chromosome complement. Bicolor FISH showed that co-localization of the 5S and 45S rDNA on two terminal and five interstitial loci. This phenomenon might indicate a natural hybridization with closely related genera and/or genome rearrangement.
|
2022-12-20T00:47:58.624Z
|
86,805,920 |
{
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"DOI": "10.25308/ADUZIRAAT.422021",
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},
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"status": null,
"url": null
}
|
Hem insan sagligi hem de doganin korunmasi icin organik beslenme, organik urun yetistirme ve organik tarim yapma onemle dikkat edilmesi gereken bir durumdur. Bu calisma, Siirt il merkezindeki tuketicilerin organik urunlere yonelik tercihlerini ve organik urunleri tercih etmelerinde etkili olan faktorleri belirlemek amaciyla yapilmistir. Arastirma materyali olarak, Siirt ili kent merkezindeki 271 birey ile 2017 yilinda yapilan anket calismasindan derlenen yatay kesit verileri kullanilmistir. Arastirma bulgularina gore; tuketicilerin %63’unun erkek, %71’inin bekâr oldugu, tuketicilerin yas ortalamasinin 34.2 ve aylik gelirlerinin ise 1200 TL oldugu belirlenmistir. Organik urunler hakkinda bilgi sahibi olan tuketici orani %71.8 olarak bulunurken, bilgi kaynagi olarak %46.8 ile internet ilk sirada yer almistir. Tuketicilerin %84.3’u organik urun tukettigini ifade etmis ve tuketilen organik urunler arasinda %62.2 ile yas sebze ve meyve ilk tercih olarak belirlenmistir. Sonuc olarak; organik urunlerin guvenli olmasi ve organik urunlerinin sagliga zararli olmamasi, gibi faktorlerin organik urun tuketim tercihini etkileyen en onemli faktorler oldugu saptanmistir. Kontrol ve sertifikasyon ile ilgili olarak tuketici bilincinin olusmamasi, reklam faaliyetlerinin yetersiz kalmasi ve pazarlama onemli sorunlar arasinda yer almaktadir. Pazarlama marjinin tuketici lehine olmasi, organik urun satis yerinin guvenilirligi ve temizligine yonelik yapilacak calismalarin organik urunlerin tuketimini arttiracagi sonucuna varilmistir.
|
2022-06-04T14:53:59.275Z
|
41,946,722 |
{
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"DOI": "10.1056/NEJM197001012820109",
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"url": null
}
|
INTRACRANIAL aneurysms of peripheral cerebral arteries are rare. If trauma is not a consideration1 2 3 4 5 emboli or a local inflammatory process should be regarded as possible. In the nineteenth c...
|
2022-12-21T10:23:37.379Z
|
223,428,620 |
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"DOI": "10.3760/CMA.J.ISSN.1673-4904.2006.02.024",
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|
目的 探讨脑弥漫性轴索损伤(DAI)MRI特征以及诊断价值.方法23例患者均有MRI检查,其中有16例还有CT检查.分析23例DAI患者的临床资料和影像学特点,进行回顾性分析.结果DAI发生于以下部位:胼胝体6例,皮髓交界处7例,脑白质7例,脑干6例,基底节5例,小脑3例,脑室5例.多发病灶共19例.23例DAI患者中20例为交通伤.本组DAI伴其他脑伤者18例.CT检查难以发现病灶的小脑、脑干和胼胝体等处(9/23),MRI均可以清晰显示.结论MRI对发现DAI的诊断价值较大.CT检查难以发现在小脑、脑干和胼胝体等处的病灶,MRI可以清晰显示.但是CT发现合并的颅骨骨折优于MRI。
|
2022-01-27T19:00:32.184Z
|
96,769,079 |
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"DOI": "10.1063/1.1714579",
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"status": null,
"url": null
}
|
In metallic alloys the stress‐induced reorientation of solute pairs produces an anelastic relaxation called the Zener effect. To determine whether or not this relaxation is also observable in a nonmetallic solid solution, internal friction of single crystals of NaCl plus (1.3% to 1.7%) KCl is measured at 4 to 10 kc/sec. A maximum in the damping occurs near 400°C for nominally pure NaCl:KCl and near 300°C for NaCl:KCl crystals with CaCl2 added to enhance the cation vacancy concentration. This behavior indicates that the Zener relaxation is present in NaCl:KCl. Diffusion constants calculated from this Zener relaxation agree well with the results of radioisotope diffusion experiments.
|
2022-03-06T04:07:53.617Z
|
233,465,297 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ACCESS.2021.3070711",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An accurate and efficient path loss modeling method for millimeter wave communications plays a significant role in the large-scale deployment of a fifth-generation (5G) mobile communication system. Conventional path loss modeling methods such as deterministic methods, empirical methods, and machine learning-based methods, in practice, cannot achieve the desired level of performance in terms of accuracy. This paper proposes a novel path loss model for 5G communications in suburban scenarios using deep learning with dilated convolution and attention. Dilated convolution is used to alleviate the locality of feature extraction and capture the global information on input images. Attention rendered by global context blocks helps the attention-enhanced convolutional neural network (AE-CNN) model utilize the global information on inputs to extract essential features of propagation environments. A distance-embedded local area multi-scanning algorithm which generates input images that can improve learning the latent features with dependency on distance is proposed. The experimental results indicate that the AE-CNN model can outperform state-of-the-art deterministic and empirical methods in terms of root mean square error in test scenarios.
|
2022-11-14T08:17:00.685Z
|
56,906,894 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1538-7445.AM2015-4287",
"MAG": "2561986773",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Talimogene laherparepvec is an investigational oncolytic immunotherapy based on a modified herpes simplex virus type-1 (HSV-1) immunotherapy designed to selectively replicate in tumors and to initiate an anti-tumor immune response. Intralesional administration of talimogene laherparepvec is intended to result in oncolysis within injected tumors. Iterative replication of virus within permissive tumor tissue results in lytic cell destruction and local release of progeny virus and tumor derived antigens. GM-CSF, a product of the viral transgene, is also produced locally such that it can recruit and stimulate antigen presenting cells which, in addition to relevant tumor-derived antigens, are required for the initiation of a systemic antitumor immune response. The talimogene laherparepvec-induced immune mediated mechanism of action in both the virus-injected and distant tumors have yet to be fully understood therefore, we evaluated viral replication, tumor cell lysis, and the changes in immune cell populations in both the injected and distant tumors using syngeneic contralateral tumor models. Animals received a single intratumoral dose of the murine surrogate of talimogene laherparepvec (OncoVEXmuGM-CSF), which induced regression in the majority of virus-injected tumors and tumor growth inhibition/regression in the contralateral (uninjected) tumors. HSV-1 antigen was only detected by IHC in the virus-injected tumor and not the contralateral tumor (and no other tissues). Virally-mediated tumor destruction (oncolysis) was also localized to only the virus-injected tumor. In preliminary experiments, morphometric analysis of the tumor tissue revealed that the percent area of CD3+ and CD8+ lymphocytes were significantly increased in both the virus-injected and contralateral tumors compared to the formulation control mice. In addition, the percent area occupied by CD103+ cells (a marker found on potent cytotoxic T cell stimulating dendritic cells) was increased in the virus-injected tumor compared to the contralateral tumor and the tumors in the control animals. Although cellular infiltration was increased in both virus-injected and contralateral tumors and was inversely correlated with tumor volume, the decreased volume of injected tumors was attributed to viral oncolysis. Taken together these data supports that talimogene laheparepvec activates a systemic T cell mediated anti-tumor immune response. Citation Format: Julia Piasecki, Jim Rottman, Tiep Le, Rafael Ponce, Courtney Beers. Talimogene laherparepvec activates systemic T-cell-mediated anti-tumor immunity. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4287. doi:10.1158/1538-7445.AM2015-4287
|
2022-11-27T17:26:13.735Z
|
24,683,402 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/JPHOTOV.2013.2284064",
"MAG": "1969126562",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Reflection losses limit the efficiency of all types of photovoltaic devices. The first reflection loss occurs at the glass-air interface of the photovoltaic module. If no light trapping mechanism is used about 4% of the solar energy is lost at this surface. Currently, most commercial thin-film CdTe solar modules are manufactured using NSG TEC10 glass, with no light trapping mechanism addressing the reflection at the interface of the glass with the atmosphere. To minimize the losses, a broadband multilayer thin-film coating has been designed and deposited onto the glass surface of a thin-film CdTe solar cell. The coating consisted of four dielectric layers of alternating thin films of ZrO2 and SiO2 . The layers were deposited by using high-rate-pulsed dc magnetron sputtering. Spectrophotometer measurements confirm that the transmission increased by between 2% and 5% over the spectrum utilized by the thin-film CdTe solar cell. The weighted average reflection reduced from 4.22% to 1.24%. Standard test conditions (STC) solar simulator measurements confirmed a 0.38% increase in absolute efficiency and a 3.6% relative increase in efficiency.
|
2022-12-07T22:26:22.849Z
|
25,819,315 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/j.1460-2075.1994.tb06722.x",
"MAG": "167771405",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
The A mating type genes of the mushroom Coprinus cinereus encode two classes of putative transcription factor with distinctive homeodomain motifs (HD1 and HD2). A successful mating brings together different allelic forms of these genes and this triggers part of a developmental sequence required for sexual reproduction. In this report we provide evidence that this developmental programme is promoted by a physical interaction between the two classes of homeodomain protein. Rare dominant mutations conferring self‐compatibility map to the A locus and result in constitutive operation of the A‐regulated developmental pathway. Our molecular analysis of one of these mutations shows that it has generated a chimeric gene by inframe fusion of an HD2 and an HD1 gene. Fusion has overcome the normal incompatibility between two proteins coded by genes of the same A locus and generated a protein that is sufficient to promote development in the absence of any other active A mating type genes. The fusion protein retains most of the HD2 sequence, but only the C‐terminal part of the HD1 protein. It has only the HD2 homeodomain motif as a potential DNA binding domain fused to an essential C‐terminal region of the HD1 protein, which in a normal HD1‐HD2 protein complex may be the major activation domain.
|
2022-12-18T05:28:31.210Z
|
235,914,773 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10572252.2021.1930183",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Black mother activists play a pivotal role in redressing community inequities. To address the work of these activists, I turn to technical and professional communication and reproductive justice to explore how ethos is central to their work.
|
2022-12-30T18:10:14.828Z
|
241,046,509 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31399/asm.ad.ss1307",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Sanicro 28 is a high alloy for oil country tubular goods with cold work in the alloy for high strength. See Alloy Digest SS-831, September 2001, which covers the use of Sanicro 28 as a superheater material for waste-derived fuel plants. This datasheet provides information on composition, physical properties, hardness, and elasticity. It also includes information on corrosion and wear resistance as well as heat treating. Filing Code: SS-1307. Producer or source: Sandvik Steel Company.
|
2022-01-27T14:06:22.449Z
|
167,089,716 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31646/WA.65",
"MAG": "1887345542",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In 1981 the Australian Science and Technology Council produced a report entitled “Towards a Marine Sciences and Technologies Programme for the 1980’s”. This report marked a much needed awakening to the need for Australia to develop it’s marine resources and to assume responsibility for the stewardship of its coastal waters and the 200 nautical mile offshore zone. The report also stressed that co-operative programmes were needed to pursue national objectives that relate to economic exploitation of marine resources, management and conservation policies and the fulfilment of social responsibilities.
At about the same time the decision was made by CSIRO to locate its Divisions of Oceanography and Fisheries Research in Hobart, so vacating the miarne laboratories at Cronulla in New South Wales. Almost simultaneously, and to the deep regret of all marine scientists, the decision to close the Roche Research Institute of Marine Pharmacology was announced. These two decisions meant that the prosecution of marine science in New South Wales suffered a severe set-back. Opportunities for collaborative research, educational co-operation, and employment for marine scientists in New South Wales were all reduced. We have paradox in New South Wales of the Australian Science and Technology Council calling for “the efficient deployment and progressive development of the resources, facilities and expertise in government agencies, educational research institutions and in industry”, while at the same time the nexus in the marine sciences between industry, government agencies and educational and research institutions was being dismantled.
|
2022-02-08T19:09:41.835Z
|
84,939,123 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4067/S0717-73562004000400001",
"MAG": "2050108339",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Resumen es: Se analiza el macroespacio comprendido entre la cordillera de la costa y la peninsula de Mejillones, a traves de la recreacion de las formas de vida y el...
|
2022-03-11T08:32:52.578Z
|
43,148,137 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1542/peds.95.5.771",
"MAG": "1788477252",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The syndromes of child abuse or non-accidental injury (NAI) are readily recognized. The frequency of NAI requires that it be considered in any child who has been, or appears to have been, traumatized. Nevertheless, great care must be exercised to avoid the parental anxiety and stress that may result from the mistaken diagnosis of child abuse.1 Many conditions mimic NAI, and even well-described ones may be overlooked due to their present rarity.
CASE REPORT
This 10-week-old female infant was comatose, hypotensive, with poorly perfused extremities, and had received cardiopulmonary, resuscitation (CPR). She was the first-born child of a 24-year-old Hispanic mother and a 32-year-old Jewish father.
|
2022-09-13T14:38:13.221Z
|
201,652,318 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.9745/GHSP-D-18-00399",
"MAG": "2970649103",
"PubMedCentral": "6711620"
},
"license": null,
"status": null,
"url": null
}
|
Voluntary contraceptive uptake among postabortion care clients treated with misoprostol in Rwanda was high and unhindered by the extended bleeding that sometimes occurs with misoprostol use. However, provider knowledge regarding return to fertility and contraceptive methods appropriate for postabortion care clients should be strengthened. Voluntary contraceptive uptake among postabortion care clients treated with misoprostol in Rwanda was high and unhindered by the extended bleeding that sometimes occurs with misoprostol use. However, provider knowledge regarding return to fertility and contraceptive methods appropriate for postabortion care clients should be strengthened. ABSTRACT Introduction: Unsafe abortion remains a problem in Rwanda, where abortion is highly restricted by law. To reduce mortality and morbidity from unsafe abortion, Rwanda implemented a national postabortion care (PAC) program in 2012, which included using misoprostol to treat incomplete abortion. Key components of PAC are offering and providing voluntary contraceptive methods and counseling on their use, but little is known about contraceptive uptake among PAC clients treated with misoprostol. The objectives of the current study were (1) to assess the contraceptive uptake of PAC clients treated with misoprostol, including whether extended bleeding hinders uptake; and (2) to assess providers’ knowledge of contraception and their willingness to counsel PAC clients on contraception, provide methods, or refer for contraceptive services. Methods: We surveyed 68 PAC clients treated with misoprostol and 43 providers (84% nurses) in 17 health facilities across 3 districts in Rwanda where misoprostol for PAC had been introduced recently. PAC clients were recruited into the study prior to facility discharge and surveyed between 10 days and 1 month after discharge. We asked PAC clients and providers about demographic characteristics and attitudes toward contraception. We also asked PAC clients about contraceptive counseling received and postabortion contraceptive uptake or reasons for nonuse, and providers about their knowledge about return to fertility, pregnancy and contraceptive counseling, practices related to contraceptive method provision, and their knowledge and potential biases about PAC clients using contraception. We used descriptive statistics for analysis. Results: PAC clients were 19–46 years old, and most (69%) had at least 1 child. Almost all PAC clients (94%) reported being counseled on contraception, but only 47% reported choosing and receiving a method before being discharged from the facility. Nevertheless, by the time of the survey, 71% reported using a method. PAC clients’ main reason for not using contraception was wanting to become pregnant. Only 1 woman reported nonuse because of bleeding. Among providers, more than half (56%) reported there are contraceptive methods PAC clients should never use and about a quarter (26%) reported incorrect information on when PAC clients’ fertility could return. Conclusion: We found no evidence that bleeding associated with misoprostol for PAC influenced women's contraceptive uptake. However, as PAC programs expand to include misoprostol as a treatment option, accurate and high-quality postabortion contraception counseling and method provision at both treatment and follow-up visits must be strengthened.
|
2022-09-15T04:46:09.249Z
|
119,468,052 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREV.110.1395",
"MAG": "1986753942",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The methods for treating center-of-mass motion in the nuclear shell model are reviewed. The existence of inherent difficulties of principle is pointed out for any method which attempt to remove center-of-mass effects from a shell-model wave function without considering the relation of the shell-model wave function to the Hamiltonian of the real nucleus. (auth)
|
2022-10-24T20:44:45.402Z
|
110,020,265 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.944259",
"MAG": "2092936692",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Semiconductor injection lasers are required for implementing virtually all spaceborne remote sensing systems. Their main advantages are high reliability and efficiency, and their main roles are invisioned in pumping and injection locking of solid state lasers. In some shorter range applications they may even be utilized directly as the sources.
|
2022-12-14T05:15:59.677Z
|
209,524,105 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/ijerph17010207",
"MAG": "2998154547",
"PubMedCentral": "6981922"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1660-4601/17/1/207/pdf?version=1577444864"
}
|
Background: Liraglutide is the first glucagon-like peptide-1 receptor agonist (GLP-1 RA) based on the human GLP-1 sequence, with potential weight loss benefits, approved for the treatment of type 2 diabetes (T2D) mellitus. Herein, we aimed to assess the 5-year effectiveness of Liraglutide in the management of weight and glycometabolic control in a Southern Italian cohort of overweight/obese T2D patients, who were naïve to GLP-1 RAs. Patients and Methods: Forty overweight or obese patients treated with Liraglutide at doses up to 1.8 mg/day, in combination with one or more oral antidiabetic agents, were retrospectively assessed at baseline, during, and after 60 months of continuous therapy. Results: After 5 years of Liraglutide treatment, body weight decreased from 92.1 ± 20.5 kg to 87.3 ± 20.0 Kg (p < 0.001), with a mean reduction of 5.0 ± 7.0 Kg and a body mass index (BMI) decrement of −2.0 ± 3.1 Kg/m2. On Spearman’s univariate analysis, change in body weight was correlated with female gender and baseline BMI. Hemoglobin A1c (HbA1c) decreased from 7.9 ± 0.9% at baseline to 7.0 ± 0.7% at the end of the study period (p < 0.001), followed by a significant reduction in fasting plasma glucose. No significant differences emerged in other biochemical parameters, despite a trend toward improvement in lipid profile. Notwithstanding encouraging effects on several markers of cardiovascular disease (CVD), increments in the 5- and 10-year risk for the first atherosclerotic cardiovascular event were documented, as four incident cases of myocardial infarction. Conclusions: Prolonging treatment with Liraglutide can lead to durable benefits in relation to weight and glycemic control, with a greater impact on women. These results extend and corroborate previous observations, suggesting that gender per se may modulate the response to Liraglutide. Despite favorable effects on some established CVD risks factors, the long-term role of Liraglutide in primary prevention of CVD in patients with T2D remains controversial.
|
2022-12-21T11:16:05.928Z
|
137,291,450 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2320/MATERTRANS.MH201415",
"MAG": "1912557350",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Microtension tests were performed on single crystals with different crystallographic orientations, which were prepared using an 18R-type long-period stacking ordered (LPSO) structure in a directionally solidified Mg85Zn6Y9 alloy. Anisotropic plasticity was observed for the LPSO phase specimens. Cleavage cracking occurred on the prismatic planes in a crystal with its loading direction parallel to the basal plane. The cleavage stress for the prismatic plane was determined to be approximately 460MPa. A crystal that was oriented favorably for gliding on the basal plane exhibited a critical resolved shear stress of approximately 9.4MPa. When a crystal was loaded along [0001], a sudden load drop was observed at a stress of approximately 250MPa in the initial linear region of the stressstrain relation. Transmission electron microscopy results after the load drop showed that the deformation microstructure contained a twin-like boundary with a rotation axis along 1⁄211 20 . [doi:10.2320/matertrans.MH201415]
|
2022-12-23T02:27:46.019Z
|
178,535,644 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/1612197X.2014.982677",
"MAG": "2045967829",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Olympic Games represent the biggest and third biggest sporting occasions in the world (Summer and Winter, respectively). As such, dealing with the various challenges and optimising performance at this event has been an important dual focus for team leaders, coaches, performers, and their supporting sport psychologists. In this paper, we share an organisational approach to planning and preparation that, in our experience, provides an effective set-up for athletes, coaches, and support teams alike. Specifically, this presented framework enables the focused tasking of support staff and resources to address both individual and specific challenges. To illuminate the route via which this approach delivers its impact, underpinning mechanisms, advantages, and other considerations are also presented.
|
2022-09-08T07:42:01.707Z
|
119,489,577 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/(SICI)1521-396X(199809)169:1<25::AID-PSSA25>3.0.CO;2-0",
"MAG": "1964351213",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Non-basal dislocation loops, both vacancy and interstitial types, are observed in graphite samples using a scanning tunneling microscope. Both types of dislocation loops have a variety of shapes, including circular, elliptic, and linear (short lines). No evidence is found for the dissociation of dislocations, supporting the view that the energy difference between dissociated and non-dissociated dislocation loops is very small.
|
2022-12-10T04:08:02.374Z
|
16,487,385 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12988/IJMA.2015.56158",
"MAG": "2522992870",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Waves develop amplitude change during the propagation. For the simplest case, this has been shown by bichromatic waves, waves that contain two frequencies. The waves of larger amplitudes and smaller frequency differences showed more significant amplitude deformation. The amplitude deformation can be explained from the so-called side band interactions. Perturbation method for diffusive and 2122 Edi Cahyono et al. nonlinear equation is applied to show the amplitude deformation. The solution is in the form of a series expansion of the amplitude as Stokes’ approach for single frequency waves. Stokes’ approach shows that the dispersion relation involves the amplitude. However, this does not explain the amplitude deformation. Therefore, this paper discusses bichromatic wave solution of diffusive and nonlinear equation. Moreover, the focus is on a hidden parameter appears in the series expansion, namely the wave number difference. The parameter of wave number difference may affect the convergence of the series expansion. The relation among the parameters of amplitude, wave number and wave number difference for the convergence of the series is presented.
|
2022-12-12T03:55:31.641Z
|
3,530,490 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5670/OCEANOG.2008.70",
"MAG": "2313859039",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
New Brunswick, NJ, USA. Th is aticle as been pulished in O ceagraphy, Vlum e 1, N um er 1, a qurterly jornal of Th e o ceagraphy soiety. coyright 2008 by Th e o ceagraphy soiety. a ll rhts rerved. perm ision is gnted to cpy his aticle or se in teching nd rearch. replication, sstem m tic repruction, or coective redirbution of ny prtion of his aticle by phocopy m acine, repsting, or oher m eans is perm ited only w ith he aproval of Th e o ceagraphy soiety. send ll corrondence o: ifo@ tos.org or Th
|
2022-12-30T18:54:02.419Z
|
234,046,564 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22070/NIC.2021.13921.1063",
"MAG": "3129162373",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
همگام با گسترش تحولات شگرف و تعاملات نوین، جوانان و نسلهای جدید عمدتا تحت تاثیر ابعاد جدیدی از نقشآفرینی نخبگانی و شخصیتهای اجتماعی در قالبهایی نظیر نخبگان سمبولیک(ستارگان سینمایی، ورزشی و هنری) قرار گرفتهاند. اگرچه در نگاه نخست، تغییر در وضعیت و چیدمان نخبگانی محصول طبیعی شرایط و مقتضیات زمانی محسوب شده و می-تواند تاثیرات مفیدی بر جامعه داشته باشد، اما این موضوع زمانی تبدیل به چالش جدی خواهد شد که این گروه جدید از نخبگان در نقش پیشرانهای اصلی جامعه عمل نموده و عملا جایگزین نخبگان فکری شده و به موضوعات تخصصی و سیاستهای کلان جوامع نظیر خطدهیهای سیاسی، اقتصادی و حتی ایدئولوژیک مبادرت نمایند. هدف: پژوهش حاضر درصدد است با رویکرد آیندهپژوهی و روش سناریونویسی به این پرسش بپردازد که نخبگان علمی در مواجهه با تحولات الگوهای اثرگذاری نخبگان در جوامع، چگونه میتوانند به جایگاه اصلی خود جهت توسعه و پیشرفت جهان اسلام بازگردند؟ فرضیه اصلی: نخبگان و اندیشمندان درصورتی به مرجعیت فکری و راهبری جوامع نائل میشوند که بتوانند اولا متناسب با ویژگیهای اصیل جوامع، شناخت نیازها و مطالبات مردمی و ثانیا با بکارگیری ظرفیتها و شیوههای تعاملاتی جدید مانند فضای مجازی و همراهسازی نخبگان سمبولیک، ایدههای خود را تبدیل به ارزشهای فراگیر در جامعه نمایند. یافته پژوهش: گسترش تعاملات بینالمللی مانند فضای مجازی فرصتهای نوینی فراهم مینماید تا نخبگان فکری جهان اسلام با تکیه بر ارزشها و باورهای مشترک جهانشمول اسلامی ناظر بر کرامت انسانی بتوانند علاوه بر تاثیرگذاریهای داخلی جهت توسعه، به عنوان یکی از پیشرانهای اصلی جهت همگرایی جهان اسلام محسوب شوند.
|
2022-01-23T02:57:36.824Z
|
163,234,603 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.2307/2906347",
"MAG": "2320813094",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The appearance on August 1, 1918, of Eternidades, a collection of verso desnudo from 1916-1917, fullyjustified the success of El diario de un poeta reciencasado and validated Juan Ramon Jimenez' position as doyen of Spanish poetry. Even Rafael Cansinos-Assens, chronicling the turmoil of creacionismo, acknowledged the renovating spirit behind the book from an author essentially at odds with the Spanish vanguard: "Tan solo Juan Ramon Jimenez profiaba por evadirse de los alveolos de sus antiguas colmenas, llevando sus abejas a los nuevos claustros de rota arquitectura en Eternidades."2 Three of the first five pieces in Eternidades are metapoems: "Accion," ";lntelijencia, dame," and "Vino, primero, pura."3 Their presence initiates a period in Juan Ramon's work in which, like Mallarme and Valery, he will expend creative energy turning into poetry deliberations on the act of poetry. The first metapoem is simply a healthful recognition of fluidity and apprenticeship, with possible overtones from romanticism about the weakness of words: "No se con que decirlo / porque no esta hecha todavia mi palabra." The third poem's dance of the veils-"Vino, primero, pura"-enjoys' the privilege of being a set piece in contemporary Spanish poetry. By contrast, "ilntelijencia,
|
2022-02-08T21:20:37.515Z
|
152,510,145 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5539/ELT.V8N6P111",
"MAG": "1519576551",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study aimed to investigate the effects of the online course tools, specifically discussion boards, blogs and wikis, the built-in facilities of Blackboard as computer-mediated communication integrated in e-learning environments on improving integrated reading and writing and on the attitudes of EFL college students towards literacy skills in e-learning environments. A pedagogical model was designed and described in a background of relevant research. The study made use of both quantitative and qualitative data to investigate the effects of these tools on both reading/writing performance and on attitudes. The findings indicated that the students’ performance on an integrated reading/writing test was improved and so were their attitudes towards literacy skills. The findings also showed that the e-course tools at issue facilitated students’ interactions and supported learning of the reading/writing skills in a growing online discourse community. The paper ends with a conclusion and discussion of pedagogical implications and recommendations for prospective research.
|
2022-10-03T14:56:01.116Z
|
136,798,045 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/FAM.972",
"MAG": "2079563706",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Agaric, a kind of important combustible material in the fire of Hengyang merchant's building, was investigated using different experiment equipments. Its degradation and pyrolysis behavior were studied by means of thermogravimetric and kinetic analysis and pyrolysis gas chromatography–mass spectroscopy analysis. External radiation heat and internal heat were used to ignite the agaric. For external radiation ignition, a series of bench‐scale fire tests were done in cone calorimeter in accordance with ISO 5660. As for the internal heat ignition, a fire test was carried out in a full‐scale room in accordance with ISO 9705. Multi‐parameter measurement, including heat release rate (HRR), mass loss rate (MLR), temperature field and species concentration, has been accomplished. Meanwhile, the process of a full‐scale fire test was numerically simulated. The computational results were consistent with experiment data, which will lay down a good foundation for further study in fire reconstruction of the whole fire. Copyright © 2008 John Wiley & Sons, Ltd.
|
2022-10-14T00:48:49.427Z
|
253,440,805 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.51878/teacher.v2i3.1624",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYSA",
"status": "HYBRID",
"url": "https://jurnalp4i.com/index.php/teacher/article/download/1624/1563"
}
|
Writing an exposition text has not yet obtained the maximum score according to the minimum completeness criteria of the school. So we need a method to make it easier for students, namely mind mapping. Obtaining the results of increasing the ability to write expository texts through mind mapping is the goal of the research. MAN 1 Aceh Timur became the research site. A total of 18 students of class X MIA 1 in the academic year 2021/2022 became the subjects of the research. Classroom Action Research (CAR) is a research design through four research steps, namely planning (plan), action (action), observation (observation) and reflection through two cycles. Tests and observations become instruments in research. Data analysis was carried out through a qualitative approach by calculating the class average value using the classical completeness percentage. Students who get a KKM score of 75 are declared complete. The results showed that the ability to write expository texts through mind mapping at MAN 1 Aceh Timur in the first cycle was 55.55%% or 10 students in the poor category. Meanwhile, after being given the second cycle, the results showed 100% or 18 students. Based on the results of the study, it was concluded that students' ability to write expository texts through mind mapping could increase.
ABSTRAKMenulis teks eksposisi belum memperoleh nilai yang maksimal sesuai dengan kriteria ketuntasan minimal sekolah. Sehingga diperlukan suatu metode untuk memudahkan siswa yaitu dengan mind mapping. Memperoleh hasil peningkatan kemampuan menulis teks eksposisi melalui mind mapping merupakan tujuan dari penelitian. MAN 1 Aceh Timur menjadi tempat penelitian. Sebanyak 18 siswa kelas X MIA 1 pada tahun ajaran 2021/2022 menjadi subjek dalam penelitian. Penelitian Tindakan Kelas (PTK) merupakan desain penelitian melalui empat langkah penelitian yaitu perencanaan (plan), Tindakan (action), pengamatan (observasi) dan refleksi melalui dua siklus. Tes dan observasi menjadi instrument dalam penelitian. Analisis data dilakukan melalui pendekatan kualitatif dengan menghitung nilai rata-rata kelas menggunakan persentase ketuntasan secara klasikal. Siswa yang mendapatkan nilai KKM ?75 dinyatakan tuntas. Hasil penelitian menunjukkan kemampuan menulis teks eksposisi melalului mind mapping di MAN 1 Aceh Timur pada siklus I sebesar 55,55%% atau 10 siswa dengan kategori kurang. Sedangkan setelah diberikan siklus II menunjukkan hasil sebesar 100% atau 18 siswa. Berdasarkan hasil penelitian disimpulkan kemampuan siswa dalam menulis teks eksposisi melalui mind mapping dapat meningkat.
|
2022-11-11T16:05:51.506Z
|
55,374,212 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5897/AJB12.2846",
"MAG": "2140946826",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Damping off caused by Sclerotium rolfsii on cowpea results in yield losses with serious socioeconomic implication. Induction of defense responses by plant growth promoting rhizobacteria (PGPR) is largely associated with the production of defense enzyme phenyl ammonia lyase (PAL) and oxidative enzymes like peroxidases (PO) and poly phenol oxidase (PPO). In the present study, the effect of plant growth promoting rhizobacteria (Pseudomonas fluorescence (bv. V)) on both damping off development and growth parameters in cow pea seedlings were investigated. The best reduction in pre and post emergence damping off in cowpea seedlings was observed in BCPF 8-treated samples. Seed bacterization with BCPF 8 significantly increased peroxidase (PO), polyphenol oxidase (PPO), and phenylalanine ammonia-lyase (PAL) activities. The activation of these defense reactions by BCPF 8 was correlated with an enhanced resistance to damping-off caused by S. rolfsii. This study demonstrated the ability of the rhizobacteria BCPF 8 to induce systemic resistance in cowpea, suggesting that this legume is an Induced systemic resistance (ISR)-positive plant.
|
2022-11-22T18:08:25.835Z
|
248,677,355 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/min12050592",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2075-163X/12/5/592/pdf?version=1652231522"
}
|
The goal of this work was to study the bioleaching of arsenic-containing polymetallic concentrate that contained 6.2% Cu, 7.3% Zn and 1.7% As, depending on different temperatures and in the presence of CO2 and molasses in the medium, as well as the difference in the composition of microbial population formed under various conditions. A mixed population of moderately thermophilic and thermotolerant acidophilic microorganisms formed during the continuous bioleaching of copper concentrate was used as an inoculum. The experiments were carried out in a continuous mode in laboratory scale reactors, with a temperature range of 40 °C to 60 °C. To assess the effect of CO2 and molasses on metal leaching and microbial population composition, the experiments were carried out in three reactors: CO2 (~0.01 L/min) was supplied into the first reactor; 0.02% molasses were added to the pulp of the second reactor; and no additional carbon sources were supplied into the control reactor. The highest copper recovery (27%) was achieved at 50°C in the experiment with molasses, while the highest zinc recovery (82.1%) was reached at 45°C in the control experiment. Additional carbon sources affected the extraction of non-ferrous metals only at 60 °C and increased the extraction of copper and zinc by 12.6% and 24.2%, respectively. Both the temperature and carbon source used affected the microbial population composition. The main microbial genera revealed in the populations by next generation sequencing (NGS) were bacteria of the genera Sulfobacillus and Acidithiobacillus, as well as archaea of the genera Ferroplasma, Acidiplasma, and Cuniculiplasma. At low temperatures (40 and 45 °C), Acidithiobacillus, Sulfobacillus, and Ferroplasma predominated, while at temperatures 50–55 °C, the decrease in relative abundance of these genera occurred, and the predominance of Acidiplasma archaea was observed. The usage of both CO2 and molasses led to the increase in Sulfobacillus and Acidiplasma in relative abundance.
|
2022-11-28T17:34:17.872Z
|
229,447,007 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25267/pragmalinguistica.2020.i28.05",
"MAG": "3107841782",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://revistas.uca.es/index.php/pragma/article/download/6451/6819/29284"
}
|
This article explores the English phraseological verb constructions found within the verb argument construction (VAC) in the expressions used during the maritime towage operations which present the semantic feature [+MOVEMENT]. The purpose of this study, which is based on a specialised ad hoc corpus, is to identify the verb phraseological constructions and represent their syntactic and semantic properties. This will help to lay the foundations for the building of a term-ontological tool that may contribute to the enhancement of the terminological and contextual competences of the language professionals and of maritime language users. The corpus enquiry method has been both semasiologically and onomasiologically approached through the establishment of a step-by-step procedure for exploring the verb+argument patterns and the application of the push/pull verb class by Levin (1993). The result of this study is the contribution of an inventory of English verb phraseology for the maritime towage operations.
|
2022-12-02T11:19:19.106Z
|
143,650,542 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/iclqaj/27.3.665",
"MAG": "2007792945",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
IN 1972, four schoolboys aged 15 in the Isle of Man were reported by a prefect for taking beer into their school, for which offence they were caned. The boys later set upon the prefect, and one of them, Anthony Tyrer, was convicted of assault occasioning actual bodily harm, for which offence he was sentenced (in the words of the relevant Isle of Man legislation) to be whipped. Three strokes of the birch were subsequently administered on his bare buttocks. From these humble beginnings developed the Tyrer case which culminated over five years later in a •udgment of the European Court of Human Rights which has aroused more interest in the United Kingdom than any other decision of the Court (with the possible exception of the Irish case *) and has certainly provoked more comment hostile to the Court and the Convention than any other. The period when the judges of the Court moved with great caution, lest they forfeited the confidence of member States and thus jeopardised the future of the Convention, appears to be at an end, or else they miscalculated the British reaction, thinking that the British Government's opposition to corporal punishment made safe their own condemnation.
|
2022-12-13T11:02:33.165Z
|
35,595,589 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/APEC.2004.1296049",
"MAG": "2102814193",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Portable electronics applications often require a system voltage that is within the range of fully-charged to semidischarged batteries, for example 3.3 V output from a 2.8 V to 4.2 V lithium-ion battery input. The optimal solution to this requirement is a high-efficiency, noninverting buck-boost, DC-DC converter, providing a programmable constant output voltage, typically from single cell Li-ion, multicell NiMH, or alkaline power sources. This solution uses a control scheme which provides automatic and smooth transition through boost, buck-boost and buck modes.
|
2022-12-17T12:49:13.393Z
|
72,557,234 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/2947884",
"MAG": "2071212076",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Analysis of data collected in 7 developing countries 4 Latin American countries (Colombia Costa Rica Mexico and Panama) 2 Asian countries (Korea and the Philippines) and 1 African country (Kenya) as part of the World Fertility Survey (WFS) indicates that knowledge of a family planning outlet is significantly and positively related to an increase in contraceptive use even when several factors thought to influence fertility desires are held constant. Contraceptive use may increase because knowing an outlet may provide couples who desire to control the number and spacing of their children with the means to do so. Once women know of an outlet differences in travel time do not seem to be an important determinant of contraceptive use. Part of the reason may be that the knowledge of a family planning outlet is itself a measure of the outlets proximity. However educational level and the desire to stop childbearing are related to the likelihood that a woman will practice contraception. The results also indicate that knowledge of a family planning outlet is significantly related to the type of method a woman is using. Specifically women who know of an outlet are much less likely to use traditional methods. The perceived cost and travel time associated with 4 contraceptive methods the pill IUD condom and female sterilization are used to examine the relationship of these variables to the methods selected by current users in the Philippines. The choice of method is not highly sensitive to perceived cost and travel time at least among current users. In addition contraceptive users in the Philippines appear to have an unrealistic idea of the actual cost of methods that they are not currently using. Tables list percentage of currently married fecund nonpregnant women using contraceptives by knowledge of an outlet parity age child mortality family sex ratio residence husbands occupation education marital status wanted last pregnancy and wants more children.
|
2022-12-19T11:32:22.758Z
|
121,934,259 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/JOSA.70.001382",
"MAG": "2015720350",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A new method for construction of complex pseudorandom phase sequence diffusers for diffraction-limited holography is presented. The irradiance fluctuation in the reconstructed image can be suppressed by modifying the size of the sampling area associated with the specific phase terms. The advantage of this diffuser is discussed in terms of the power spectrum and the signal to noise ratio.
|
2022-02-09T19:41:49.820Z
|
124,298,945 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/03610926.2016.1177078",
"MAG": "2504954728",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT In this paper, we consider sufficient conditions for the stationary distribution of generalized Ait-Sahalia-type interest rate model. We show that if r ⩾ 2ρ − 1, then the generalized Ait-Sahalia interest rate model has a unique stationary distribution and if r < 2ρ − 1, then the generalized Ait-Sahalia interest rate model is recurrent relative to the domain (0, ϵ), for any ϵ > 0. Besides, some recursion formulas for the stationary distribution are presented. Finally, some numerical simulations are used to illustrate our results.
|
2022-02-09T18:30:26.573Z
|
227,138,186 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.1007-8118.2008.12.005",
"MAG": "3031752014",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective To summarize the experience in managing hepatic cutting surface in hepa-tectomy. Methods Fifty-eight patients receiving hepatectomy were divided into 3 groups according to the condition of the hepatic cutting surface. The hepatic cutting surface was open and managed with application of stypic powder in group A, open and cauterized by argon bistoury in group B and sutured in group C. The hemorrhage volume of wound surface, hemostasis time-consumption in operation and drainage volume, hepatic function after operation were determined and compared among the 3 groups. Results There were no significant differences among the 3 groups in age, sex, tumor size, method of hepatic portal blockage, blockage time, portal vein cancer embolus, wound surface drainage volume after operation, hepatitis immunity, blood routine, prothrombin time, AFP, albumin, pre-albumin, globumin and bilirubin (P>0.05). However, the hemorrhage volume of wound surface was signifi-cantly less in group A and C than in group B (P 0.05). Meanwhile, the change in GPT was remarkably lower in group A and B than in group C 24 h, 3 d and 7 d after operation (P<0.05). But there was no significant difference between group A and B. Conclusion The management of hepatic cutting surface will directly affect hemorrhage volume and liver function. To avoid hemorrhage, we can apply stypic powder or other he-mostatic or suture hepatic cutting surface. To avoid hepatic failure, we can make the cutting surface open to lessen the damage of remain liver. However, the best method for preventing hemorrhage and hepatic failure is to make the cutting surface open and apply stypic powder or other hemostatics. We should choose the three methods flexibly according to patients" economic and pathological conditions.
Key words:
Hepatectomy; Cutting surface management; MPH; Hemostasis; Liver function; ALT
|
2022-01-27T01:29:14.622Z
|
13,919,184 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22459/AG.08.04.2001.05",
"MAG": "2112904502",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Since 1991 Australian universities have charged fees, paid in advance (upfront), for a proportion of students undertaking postgraduate courses. In this paper it is argued that this is poor public policy, for both economic and social reasons. The conceptual basis for this case is explained fully. Given the strength of argument, it is difficult to understand why different Commonwealth governments have allowed and encouraged the expansion of postgraduate up-front fees in this period. The policy situation is particularly hard to justify since a much more equitable and efficient charging arrangement, the Higher Education Contribution Scheme (HECS), has been in place for undergraduates since 1989. The important point for policy is that HECS collects student charges contingent on incomes, and thus requires no payment at the point of entry. It is argued that a collection system of this type is a more correct policy for postgraduate education, and it is shown that such a reform can be implemented without administrative difficulties. In January 2001 the Federal Government announced intentions to change post-graduate fee arrangements consistent with the reform promoted in this paper. The proposal is known as the Postgraduate Education Loan Scheme (PELS), and its basis and implications are considered in what follows. It is argued that while PELS is a major advance over current arrangements its institution will have important and arguably undesirable consequences with respect to the level of student charges and, more importantly, concerning taxpayer subsidies of postgraduate education. If and when these effects come to pass, the government will face the need to change the scheme. An economically and administratively viable reform to PELS is explained and justified. A Brief History of Higher Education and Post Graduate Financing
|
2022-09-30T01:15:04.260Z
|
234,320,855 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/15427560.2020.1867551",
"MAG": "3120488699",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://www.up.ac.za/media/shared/61/WP/wp_2020_90.zp194328.pdf"
}
|
Abstract This article examines whether incorporating investors’ uncertainty, as captured by the conditional volatility of sentiment, can help forecasting volatility of stock markets. In this regard, using the Markov-switching multifractal (MSM) model, we find that investors’ uncertainty can substantially increase the accuracy of the forecasts of stock market volatility according to the forecast encompassing test. We further provide evidence that the MSM outperforms the dynamic conditional correlation-generalized autoregressive conditional heteroskedasticity (DCC-GARCH) model.
|
2022-10-26T15:15:58.746Z
|
104,566,415 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/BATTERIES4030035",
"MAG": "2885955417",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Frequency-dependent capacitance C(ω) is a rapid and reliable method for the determination of the state-of-charge (SoC) of electrochemical storage devices. The state-of-the-art of SoC monitoring using impedance spectroscopy is reviewed, and complemented by original 1.5-year long-term electrical impedance measurements of several commercially available supercapacitors. It is found that the kinetics of the self-discharge of supercapacitors comprises at least two characteristic time constants in the range of days and months. The curvature of the Nyquist curve at frequencies above 10 Hz (charge transfer resistance) depends on the available electric charge as well, but it is of little use for applications. Lithium-ion batteries demonstrate a linear correlation between voltage and capacitance as long as overcharge and deep discharge are avoided.
|
2022-12-02T11:53:07.447Z
|
145,938,407 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3289595.3289598",
"MAG": "2939132464",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The goal of library and function identification is to find the original library and function to a given machine-code snippet. These snippets commonly arise from penetration tests attacking a remote executable, static malware analysis or from an IP infringement investigation. While there are several tools designed to achieve this task, all of these seem to rely on varied methods of signature-based identification. In this paper, we argue that this approach is not sufficient for many cases and propose a design and implementation for a multitool called KISS. KISS uses lossless compression and highly optimized pattern matching algorithms to create a very compact but substantial database of library versions. In practice, KISS shows to achieve remarkable compression rates below 30 percent of the original database size while still allowing for extremely fast (sublinear) snippet identification. We use statistical tests to show that its code snippet recognition is very successful while having a number of false positives close to the lowest theoretical bound. Finally, we also argue how our approach improves the security of existing techniques as our design relies fully on complete function body verification, which prevents analysis-resilient malware from disguising as external and trusted library code. This has recently been shown to be a problem for malware analysis with existing identification solutions.
|
2022-12-13T13:54:16.437Z
|
143,568,045 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/09620210200200098",
"MAG": "1996074848",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/09620210200200098?needAccess=true"
}
|
In a world climate which is increasingly closing down as far as alternative political and social options are concerned, Cyprus as a small semi-occupied country with great European aspirations is facing a number of very serious dilemmas and teachers are faced with an extremely difficult task. The citizens they are preparing have to be passionate enough to claim a Greek-Cypriot identity; have to be tolerant and accommodating enough to live and work with Turkish-Cypriots in a re-united country, which is the main political goal of the Republic of Cyprus; have to be open-minded enough to look to a European future; and have to be ready and able to function in a globalized context. How can such a citizen be 'formulated' when there appear to be immense contradictions between what is required for each goal? What are the priorities and how are they defined? This article will attempt to address these complex issues and arrive at some conclusions regarding teacher education for a very complex new world
|
2022-12-21T10:11:44.370Z
|
121,233,323 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ANDP.19664730505",
"MAG": "2031635752",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Talbot fring result from the diffraction of light by the Talbot slit and not primarily by the grating or prism. New experiments are described demonstrating the conditions for the appearance and disappearance of Talbot fringes. Simple relations habe been derived for the observation of Talbot fringes using a prism or a grating for the spectral decomposition.
|
2022-01-27T18:47:49.974Z
|
208,516,593 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/003693309904400312",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
s of the Society's 40th annual meeting held in Dundee
|
2022-01-27T08:49:31.628Z
|
191,221,455 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4324/9781315750842.CH30",
"MAG": "1523643691",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Images add a rich dimension to theatre historical studies, which have traditionally been dominated by the literary perspective. This is particularly true for the Commedia dell’Arte, whose patchy textual record reflects its reliance on brief scenarios rather than extant play-texts with fully-scripted dialogue. From its sixteenth-century beginnings, the Commedia dell’Arte’s mixed-gender performances, distinctive costumes and gestures, and slick professional acrobatics, comedy and magic routines captured the attention of artists of every stripe. Their depictions range from reliable records of the appearance of staged events and actors, to imaginative evocations unrelated to any specific performance or performer
|
2022-02-08T09:08:50.883Z
|
75,901,795 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5833/JJGS.20.1144",
"MAG": "2321806652",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
食道癌治療において, 術前照射と手術という一連の侵襲が非特異的細胞性免疫能に与える影響はいまだ十分検討されていない. 食道癌患者108例を対象として, 未治療時, 照射後, 術後にin vitro, invivoで非特異的細胞性免疫能検査を行い, 以下の結果を得た.(1) 術前照射群では非照射群に比べて, 特に術後1ヵ月の免疫能低下が顕著となったが, 2ヵ月後にはほぼ同水準となった.(2) Concanavalin A/Phytohemagglutinin (ConA/PHA) 比は, 術後1ヵ月において, 照射群に有意な上昇 (p<0.01) がみられたが, 2ヵ月後には両群ともほぼ同水準となった.(3) 術後2ヵ月までは, 治癒切除, 非治癒切除間の免疫能の変動差に一定の傾向がみられなかった.
|
2022-02-11T06:56:31.800Z
|
140,190,237 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5979/CHA.2004.98_1",
"MAG": "2050146508",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
群落光合成の主体を担う茶園表層葉の光合成活性の周年変化を知るために,一番～四番茶葉の生育にともなう光合成活性の変化を酸素電極法で測定した。また,成熟葉の早期老化を引き起こす原因についても検討した。新葉の光合成活性が最大値に達するまでには開葉後約45日を要した。一番～四番茶葉ともに,新葉の光合成活性は次茶期芽の萌芽期まで上昇を続け,以後,活性は急速に低下し落葉した。その結果,株表層葉は2ヶ月弱の周期で一番～四番茶葉に順次更新された。越冬葉の光合成活性は比較的高かったが,一,二番茶葉の活性はそれ以下であった。一方,秋期の三,四番茶葉の光合成活性は年間で最も高い値を示した。チャ葉の早期老化の主因は新芽伸長による光環境の悪化ではなく,次茶期新芽への葉内窒素化合物の流出にあると考えられた。
|
2022-06-08T05:13:17.759Z
|
51,994,295 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1615/tsfp9.320",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents the development towards wall adaptive explicit filters for the simulation of turbulent wall bounded flows in the framework of the lattice Boltzmann method (LBM). First, we show the effect of different collision models on the characteristics of turbulent flow simulations by employing the Taylor-Green vortex as a numerical testcase. Second, an extension of the approximate deconvolution method (ADM), see Malaspinas & Sagaut (2012), Malaspinas & Sagaut (2011) and Sagaut (2010) for the simulation of wall-bounded turbulent flows is presented. A temporal dissipation relaxation is applied for explicit filtering, in order to suppress filtering in regions, where the flow is resolved and to adapt filtering in underresolved regions in such way, that the energy drain in the scales is physically motivated and consistent with the kinetic theory of turbulence. We apply the extended ADM for the simulation of a turbulent channel flow at Reτ = 180 and Reτ = 395 to demonstrate, that the ADM method of Malaspinas & Sagaut (2011) with selective viscosity filters is strictly dissipative for low-order filters. Hence, especially for wall-bounded flows the application of the proposed adaptive relaxation of the filter can be beneficial. The lattice-Boltzmann method LBM solves a set of kinetic equations in terms of discrete velocity distribution functions fα (t,x) numerically. The discrete Boltzmann equations can be written as fα (t +∆t,x+ cα ∆t) = fα (t,x)+Ωα ( fα (t,x)) (1) where Ωα ( fα (t,x)) is the collision operator, which represents non-linear and viscous effects of the Navier Stokes equations and cα is the discrete velocity set of the lattice applied. Macroscopic moments are reconstructed with a Gauss-Hermite quadrature based on the Hermite Polynomial expansion on a discrete lattice. The first two moments 1daniel.gaudlitz@aer.mw.tum.de 2nikolaus.adams@tum.de of the velocity distribution functions are the conserved moments ρ and the momentum ρu, which read ρ = ∑ α fα , ρu = ∑ α cα fα (2) while the momentum flux is the second-order offequilibrium moment of the velocity distribution functions Π = ∑ α f neq α cα cα (3) In order to reconstruct the macroscopic equations of fluid motion, a Chapman Enskog expansion is used. The interested reader can refer to Chen & Doolen (1998) among others. To close equation (1) the collision term needs to be modeled. One well-known approach is the linearization around small perturbations of the thermodynamic equilibrium. This approach is called the Bhatnagar-Gross-Krook (BGK) ansatz, see He & Luo (1997); Guo et al. (2000); Guo & Shu (2013) or Sukop & Thorne (2006) among others, which represents the collision term as a linear relaxation towards a maxwellian equilibrium Ωα ( fα (t,x)) = fα (t +∆t,x+ cα ∆t)− fα (t,x) =− τ ( fα (t,x)− f eq α (t,x) ) . (4) f eq α (t,x) is a low Mach number truncated MaxwellBoltzmann distribution, which is adjusted in such a way, that equation (3) is fulfilled and mass and momentum are conserved. A widely used formulation for f eq α is given by f eq α = ρωα [ 1+ cα u cs + 1 2cs (uu− cs δ )uu ]
|
2022-06-27T10:29:47.252Z
|
18,367,879 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/800027.808475",
"MAG": "1993855671",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://dl.acm.org/doi/pdf/10.1145/390016.808475"
}
|
This paper presents a formulation of a novel methodology for evaluation of testing in support of operational reliability assessment and prediction. The methodology features an incremental evaluation of the representativeness of a set of development and validation test cases together with definition of additional test cases to enhance those qualities.
If test cases are derived in typical fashion (i.e., to find and remove bugs, to investigate software performance under off-nominal conditions, to exercise structural elements and functional capabilities of the software, and to demonstrate satisfaction of software requirements), then the complete set of test cases is not necessarily representative of anticipated operational usage. The paper reports on initial research into formulation of valid measures of testing representativeness.
Several techniques which permit specification of expected operational usage are described, and a technique for evaluating the correlation between actual testing accomplished and expected operational usage is defined. An unbiased estimator for operational usage reliability is proposed and justified as a function of a specified operational profile; confidence in the estimate is derived from a measure of the degree to which testing is representative of expected operational application.
An experimental application of the techniques to a small program is provided as an illustration of the proposed use of the methodology for operational software reliability estimation. The relationship between structural exercise testing thoroughness and operational usage representativeness is discussed; the specification of a quantified reliability requirement and an explicit, required representativeness measure (or confidence) is identified as integral to effective application of the proposed reliability testing methodology; efforts to extend, formalize and generalize the methodology are described; and expected benefits, as well as potential problems and limitations are identified.
|
2022-11-10T14:52:00.665Z
|
216,261,791 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12775/legatio.2019.01",
"MAG": "3012261262",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://apcz.umk.pl/Legatio/article/download/LEGATIO.2019.01/24971"
}
|
In 1527, after the Sack of Rome by Imperial Troops, the Medici are chased from Florence. The oligarchic government of the Dieci is reinstated. The Dieci need a new ambassador. In particular, they need a man of trust in France, where the king ought still to be convinced to defend Florence and Tuscany against imperial troops. They choose pro-republic Bishop Giuliano Soderini of Saintes. The embassy and life of Giuliano Soderini have been strangely and almost systematically omitted in the existing literature on the subject. His letters were completely excluded from previous editions of Florentine letters of this period. This paper aims to restore them to their rightful place. It presents Giuliano Soderini’s personal and political background before and after his French mission. His diplomatic functions, needs and difficulties are detailed thanks to an extended and thorough reading of his correspondence in and out of France, preserved in France and Italy. This archival work led to the writing of an updated catalogue of his diplomatic correspondence from July 1527 to February 1529.
|
2022-12-10T08:52:49.951Z
|
52,406,202 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15779/Z384G5S",
"MAG": "1790434168",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this article, Professor Young examines the effects of diversity discourse on the teaching experience of women of color law professors. She argues that some of the most common arguments in favor of faculty diversity (that increasing faculty diversity provides positive role models, increases sensitivity to racial bias, provides resources for majority faculty members to learn about race and gender issues, and offers diverse perspectives and a more inclusive curriculum) are driven by the interests of the majority but often conflict with the professional interests of women and people of color who enter the academy. The result is that diversity discourse may actually undermine the interests of faculty of color in being considered competent professionals in their particular areas of expertise and may lead to unreasonable expectations that make teaching particularly demanding. Nonetheless, Young argues that diversity does enhance the educational enterprise but requires more than improved faculty statistics. It demands an institutional commitment to celebrate differences, strive for integration, and reject assimilation.
|
2022-12-15T10:27:31.329Z
|
196,534,558 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22159/AJPCR.2019.V12I1.29004",
"MAG": "2908485212",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: Root of Acorus calamus has been traditionally used as an anticonvulsant. The aim of the study is to assess the anticonvulsant activity of ethanolic extract of A. calamus (EEAC) by maximal electroshock seizure (MES) and pentylenetetrazol (PTZ)-induced seizure models on albino (Wistar strain) rats.Methods: Albino rats were taken and divided into five groups, each consisting of five rats both for MES and PTZ model. One group was used as control (normal saline 10 ml/kg), one as standard (phenytoin in MES model/diazepam in PTZ model), and three groups for the test drug (EEAC in the doses of 100, 200, and 400 mg/kg). In MES model, maximal electrical shock of 150 mA was passed for 0.2 s through earlobe electrodes after 30 min of giving the drugs and normal saline. Different stages of convulsions were noted down along with time spent by the animal in each phase of convulsions. In PTZ model, PTZ was injected 30 min after giving the drugs and normal saline, and onset of action and severity of convulsions were noted. Data were statistically analyzed by one-way analysis of variance followed by multiple Dunnett’s test.Results: EEAC dose dependently reduced the duration of tonic hind limb extension in MES model, and there was increase in latency and occurrence of convulsions in PTZ model.Conclusion: EEAC has anticonvulsant activity.
|
2022-02-08T07:04:57.960Z
|
83,841,760 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1749-6632.1986.TB21601.X",
"MAG": "1967873974",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The extent of interaction between phospholipids and cholesterol may contribute to the cholesterol level found in biological membranes.'** Since a correlation exists between the cholesterol and SPM contents of membranes,' there has been speculation that cholesterol interacts preferentially with SPM (reviewed by Barenholz and Thompson,' Barenholz and Gatt: and Bog&). We reported recently that the rates of radiolabeled cholesterol and phospholipid exchange between Mycoplasma gallisepticum cells and unilamellar vesicles show an inverse dependence on the degree of lipid order.' In order to compare the extent of phospholipid-cholesterol interactions, we report here the rates of lipid exchange between sphingomyelin (SPM)and phosphatidylcholine (PC)containing M . gallisepticum cells and lipid vesicles. Since interaction of phospholipids with membrane proteins could also play a role in the ability of SPM to inhibit the rate of cholesterol desorption, we also used a vesicle/vesicle exchange system to compare the effects of SPM and PC on lipid exchange kinetics. Detailed descriptions of the methods used to grow and isolate M. gallisepticum cells, prepare lipid vesicles, and perform the ['*Cj cholesterol and ['*C]phospholipid exchange measurements have appeared elsewhere. ** Briefly, the exchange of ['*C]cholesterol from donor vesicles to a 10-fold excess of acceptor vesicles uses vesicles differing in surface ~ h a r g e . ~ We incubated negatively charged donor vesicles containing radiolabeled cholesterol with neutral acceptor vesicles containing [2-'H]glycerol trioleate (a nonexchangeable marker) at the temperatures indicated in TABLE 1. Aliquots (0.2 ml) of the incubation mixture were applied to small disposable columns of DEAE-Sepharose CL-6B (pretreated with egg PC vesicles). The neutral acceptor vesicles were eluted with 1.0 ml of 20 mM sodium phosphate buffer, pH 6.0. In most experiments, the infinity value was determined after 20-24 hours. The pseudo first-order rate constant was determined by least-squares analysis of the slope of the straight line of the first-order plot, and the half-time for ["C]cholesterol exchange between vesicles was calculated from the quotient, 0.693/k. A nonspecific lipid transfer protein was used to catalyze the exchange of [14C]phosphatidylglycerol from
|
2022-02-11T01:08:11.751Z
|
250,592,363 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/d2dt02005j",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A pincer iron(III) catalyst for the oxidation and chlorination of C(sp3)-H bonds was developed. Oxidation of a diagnostic substrate cis-decalin implies that a long-lived carbon-centred radical is involved. Mechanistic studies suggest that an Fe-oxo species could be responsible for the rate-determining C-H activation step. This report expands the scope of non-heme catalysts for C-H functionalisation.
|
2022-07-28T07:58:03.154Z
|
239,631,047 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.46602/JCSN.V46I4.641",
"MAG": "3198070285",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Growing and harvesting of plants on contaminated site as remediation method is a technique that may be employed for the purpose of environmental remediation. Seeds of jute (Corchorus Olitorius), spinach (Celosia argentea) and okra (Abelmoschus esculentus) were planted on a dumpsite at Abraham Adesanya Polytechnic Ijebu Igbo, Ogun state. They were harvested five weeks after visible growth and maturation was observed. The soil from the dumpsite and harvested vegetables were dried, digested and analysed for possible absorption of heavy metals (Lead, Manganese, Copper, Cadmium and Iron) using Atomic Absorption Spectrophotometer. The analyses revealed an appreciable level of concentration (mg/kg) of manganese, iron, lead, copper and cadmium in the cultivated vegetables. However, a higher absorption capacity for Fe was observed in Abelmoschus esculentus which revealed its potential as soil remediation for Fe. Movement of Cd was also strong from the soil to all the cultivated vegetables but mild for Cu, Pb and Mn. The results obtained for the cultivated vegetables showed they are presently within the safe limits of NAFDAC and European Union but may later pose a health risk to consumers if the constant practice of refuse and sewage disposal of inorganic contaminants on the dumpsite is not controlled.
|
2022-07-31T16:57:14.093Z
|
164,911,624 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S1446788700150025",
"MAG": "2944162902",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract We give a characterization of nuclear Fréchet lattices in terms of lattice properties of the seminorms. Indeed, we prove that a Fréchet lattice is nuclear if and only if it is both an AL- and an AM-space.
|
2022-08-24T22:56:54.636Z
|
10,027,473 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PIMRC.2012.6362550",
"MAG": "1997616719",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
As it is widely known, cooperation among base stations can improve spectral efficiency, particularly at cell edges. In theory, the problem is well understood, but the application of those advanced transmission techniques in practical deployments issues multiple challenges, some of which are very difficult to model in simulation studies. In this paper we investigate the properties of intra and inter-site cooperation in the cellular uplink doing practical field measurements in an urban environment. At first we concentrate on the characterization of important channel parameters which affect the performance in cooperative networks. In particular, this includes the achievable signal-to-noise ratio as well as the synchronization accuracy. Although the results show that intra-site cooperation is less complex, especially in terms of backhaul requirements and synchronization, intersite cooperation achieves (with higher probability) more balanced SNR levels at clustered base stations and, thus, higher spectral efficiency as well. This property was veryfied in the present field trial as well.
|
2022-08-25T07:01:51.713Z
|
7,914,547 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICITECH.2017.8079980",
"MAG": "2765787228",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Nowadays, wireless sensor networks attract researchers because of their popular applications in the military, communications, intelligence and medical aspects of vitality. Wireless networks can provide solutions to a lot of major problems in the world as they are low-cost, limited energy services, and there must be mechanisms to raise the efficiency of energy consumption to ensure a long lifetime of the network. In this research, an intensive study will be presented to review the hierarchical routing protocols and their structure, and performance. However, each protocol has its extremely significant role at the moment, which opens the way for more research and development to design new protocols that are more efficient. Furthermore, this research will present the protocol's mechanisms and determine the differences among them.
|
2022-10-03T16:26:28.759Z
|
37,022,241 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TENCON.2015.7372820",
"MAG": "2249783257",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Philippines is one of the rising economies in Southeast Asia. However, it is facing a power crisis where there is a continuous increases in an already huge demand in electricity given the limited and scare supply from different power sectors. Consumers are called to be aware of their power consumption and make necessary efforts towards the smart and efficient use of it. As a response, the proponents developed an appliance-level system that monitors and analyzes power consumption. The monitoring subsystem was implemented through a portable hardware black box which includes the power meter sensor, an Arduino microcontroller clone board and a ZigBee shield for wireless transmission to a microcomputer. The Raspberry Pi microcomputer served as a temporary local server for the sync node and the gateway for the data to be stored in an online database. From this, the analysis subsystem retrieves the consolidated data to undergo both retrospective and Winter's forecasting technique. All necessary information, figures and graphs will be presented to the user for interpretation through a simple web application. Overall, the study fulfills its vision of giving people the power over their utility bills by being a tool for raising awareness towards responsibly reducing power consumption to a more efficient use.
|
2022-12-16T21:28:32.478Z
|
228,872,358 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/0950236x.2020.1844425",
"MAG": "3100832707",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Metaphors of Confinement: The Prison in Fact, Fiction, and Fantasy’s treatment of the occurrence, structure and social impact of carceral metaphoricity is unprecedented in its scale and scope. It t...
|
2022-12-17T14:05:25.656Z
|
17,010,003 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/277851.277936",
"MAG": "2062940276",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
For a wide variety of computational tasks, disk I/O continues to be a serious obstacle to high performance. The focus of the present paper is on systems that use multiple disks per SCSI bus. We measured the performance of concurrent random I/Os, and observed bus-related phenomena that impair performance. We describe these phenomena, and present a new I/O performance model that accurately predicts the average bandwidth achieved by a heavy workload of random reads from disks on a SCSI bus. This model, although relatively simple, predicts performance on several platforms to within 12% for I/O sizes in the range 16-128 KB. We describe a technique to improve the I/O bandwidth by 10-20% for random-access workloads that have large I/Os and high concurrency. This technique increases the percentage of disk head positioning time that is overlapped with data transfers, and increases the percentage of transfers that occur at bus bandwidth, rather than at disk-head bandwidth.
|
2022-12-28T20:20:46.449Z
|
242,065,967 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5296/ijch.v5i1.13312",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.macrothink.org/journal/index.php/ijch/article/download/13312/10553"
}
|
Reviewer Acknowledgements for International Journal of Culture and History, Vol. 5, No. 1, 2018
|
2022-01-27T16:42:01.384Z
|
35,411,752 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4067/S0716-10182012000700006",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
INTRODUCTION
Multiresistant nosocomial pathogens, especially Gram-negative bacilli (GNB), are a serious problem for public health systems worldwide. Due to their antimicrobial properties, copper alloys have been suggested as an alternative for the control of bacterial burden in surfaces in hospital environment. However, antibiotic multiresistance and copper resistance could be associated in GNB, and there is evidence that both kind of resistance genes (antibiotic and copper) can be located on the same genetic structures. For this reason antibiotic-multiresistant strains could survive in the presence of copper, selecting for bacterial phenotypes resistant to both antibacterial agents.
AIM
To evaluate antibacterial activity of copper against nosocomial extended-spectrum β-lactamases (ESBL) (+) and ESBL (-) GNB, and carbapenems resistant or susceptible strains.
MATERIAL AND METHOD
This study included 390 strains of GNB isolated from Chilean hospitals: Acinetobacter baumannii and Pseudomonas aeruginosa resistant (CAR R) and susceptible (CAR S) to carbapenem antibiotics, and Klebsiella pneumoniae and Escherichia coli producers and non-producers of ESBL. Susceptibility levels to cupric sulphate were determined by agar dilution method and statistical analysis were used to determine the significance of the differences in the copper tolerance levels between the strains groups.
RESULTS
Statistically superior copper tolerance levels were found in the CAR R and ESBL producing strains of A. baumannii and K. pneumoniae, in relation with the CAR S and ESBL not-producing strains.
CONCLUSION
A relation between a diminished susceptibility to ionic copper and to recent generation antimicrobial agents was observed in K. pneumoniae y A. baumannii strains.
|
2022-02-12T08:28:41.650Z
|
108,950,621 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/BEST.200490268",
"MAG": "2000221542",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Die Eisenbahntunnel der ersten Generation in Oesterreich sind heute bereits 90 bis 150 Jahre alt. Sie wurden urspruenglich in Naturstein- oder Ziegelmauerwerk hergestellt, nach 1900 auch in Stampfbeton-Bauweise. Bauwerke werden waehrend ihrer Lebensdauer unterschiedlichen Einfluessen ausgesetzt. Bei den alten Bahntunneln sind dies einmal nicht beeinflussbare aeussere Einwirkungen aus der Geologie, aus (Berg-)Wasser und Frost sowie aus Betriebsbelastungen. Sie fuehren haeufig im Lauf der Zeit zu Schaeden. Dazu kommen nachtraegliche bewusste Eingriffe in die Bausubstanz um die Funktionsfaehigkeit des Bauwerks zu veraendern. Das koennen sein: Einbau von Nischen, Massnahmen zur Elektrifizierung sowie Vergroesserung des Tunnelquerschnitts. Die Hauptschadensgruppen sind Wasserschaeden, Mauerwerksschaeden, Hohlstellen, Verformungen und Risse. Fuer die Instandsetzung wird ueberwiegend bewehrter und unbewehrter Spritzbeton eingesetzt. Fuer durchgefuehrte Instandsetzungmassnahmen wird heute eine Nutzungsdauer von etwa 30 Jahren angenommen. Einzelheiten zur erfolgreichen Durchfuehrung der Instandsetzungsarbeiten werden angegeben.
|
2022-03-27T22:34:39.948Z
|
194,100,879 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/22134360-90000137",
"MAG": "2042863606",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://brill.com/downloadpdf/journals/nwig/33/1/article-p175_13.pdf"
}
|
lijk verslag de allure van een noodkreet krijgt. Wij behoeven niet eens in herinnering te brengen wat voor de studie van Indonesische talen gedaan is om te overtuigen. Wij beperken ons tot een kort overzicht over het terrein van de Surinamistiek : stippen aan wat reeds is gedaan en wat in de naaste toekomst gedaan kan worden. Groots opgezette plannen, die voorlopig toch niet zijn te verwezenlijken, zal men hierin niet vinden. Dit overzicht is mogelijk geworden door het bibliograf isch onderzoek dat schrijver dezes in samenwerking met pater A. DoNiciE [iy) gedaan heeft. Wij kunnen niet zeggen dat dit onderzoek ons over het geheel genomen heeft teleurgesteld. Integendeel, wij hadden tevoren niet durven dromen dat zulk een rijk materiaal aan het licht zou komen. Tijdens dit onderzoek werd het ons echter ook duidelijk dat ieder ogenblik waardevol materiaal verloren dreigt te gaan. Het ontbreken van belangstelling bij officiele instanties heeft reeds belangrijke gevolgen gehad. In bibliotheken zijn tijdens recente opruimingen waardevolle geschriften verscheurd of vernietigd. Na de dood van verzamelaars evenmin lang geleden werd veel zogenaamde ,,waardeloze rommel" verbrand. Waar moest men er mee heen wanneer toch niemand belangstelling toonde ? Op deze wijze moet veel verloren zijn gegaan. De Encyclopaedie van Nederlandsch West-Indie (7, p. 503) vermeldt een Surinaamse catechismus uit ± 1750 van Andreas Mauricius, welke niet
|
2022-07-19T23:10:33.635Z
|
209,362,853 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/003591573903200742",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.sagepub.com/doi/pdf/10.1177/003591573903200742"
}
|
Professor R. A. Peters: Up to the present time seven entities have been described in the vitamin-B complex [1]. It is not yet certain that there are seven different chemical substances, but there are almost certainly five. Only two of these, vitamin B1 (also known as aneurin or thiamin) and nicotinic acid (the antipellagra factor) are important in the nutrition of man, though it is unlikely that lactoflavin is not also important, because it forms part of a tissue respiration system. The other parts of the complex are known at present only as animal factors. In the nutrition of the growing animal, deficiency of a factor soon makes itself felt by failure to grow. With the adult it must always be remembered that a deficiency only shows up when a factor is easily lost; the more tenaciously any vitamin is held by the body, the less will it be likely to be a serious element in causing gross pathological change. It is for instance hard to deprive an adult rat of lactoflavin sufficiently to cause symptoms, though the young rat cannot grow without a substantial addition to the daily diet. The most important vitamin in the group as well as the earliest to be properly defined is vitamin B1; the constitution of this we now know even by synthesis [1], and the amounts available make work upon the clinical and physiological sides more possible. For the earlier literature dealing with this vitamin, the reader is referred to an earlier paper [2], and to the book by Williams and Spies [3], and for later references to the Annual Review of Biochemistry. There is now little doubt that most if not all living cells require this factor; some bacteria, will not grow without it, and others which grow well in its absence synthesize it. Its function in the metabolism of yeast is of the greatest interest, because there is reason to believe that without it we could not have wine or alcoholic drink. It has been known for a long time that an essential stage in the production of alcohol from sugar was the conversion of pyruvic acid (CH3COCOOH) to acetaldehyde (CH3CHO) and C02, and that this w,as carried out by a special enzyme carboxylase (Neuberg [1]) ; a co-enzyme is necessary for this change called co-carboxylase (Auhagen [1]), which was lately shown to be vitamin B1 pyrophosphate by Lohmann and Schuster [4]. This is therefore essential in the production of the acetaldehyde which is subsequently converted to alcohol by reduction. It may be noted that, even in this low form of life, the vitamiin is concerned with a stage in carbohydrate metabolism, because the pyruvic acid is an intermediary in sugar degradation. In recent years, work which preceded the above discovery in yeast has shown that vitamin B1 is also concerned with carbohydrate metabolism in the higher organism. Before proceeding to a description of the more recent work on this problem, some general remarks are necessa,ry upon carbohydrate metabolism to clear the point at issue. In the higher animal there are two rather distinct phases of the sugar metabolism, that of the individual cells and that of the body as a whole. We can induce changes in the blood-sugar level (alteration in tolerance, &c.), without changing appreciably the details of the breakdown of sugar in the cells of individual tissues. On the other hand, we can imagine that there might be conditions in which locally the sugar metabolism of an individual tissue might be at fault without much effect upon the blood-sugar level. If it happened that the normal functioning of tissue cells whose metabolism of sugar was upset, was an important condition in the control of
|
2022-08-24T08:18:04.646Z
|
96,941,881 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/C4RA09626F",
"MAG": "2086964268",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
HKUST-1 MOF/silica composites with narrow mesopore size distribution were prepared by facile hydrothermal synthesis in the presence of cetyltrimethylammonium bromide (CTAB).
|
2022-10-11T18:42:13.522Z
|
221,384,877 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/EMBC44109.2020.9176440",
"MAG": "3081566259",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The analysis of gait data is one approach to support clinicians with the diagnosis and therapy of diseases, for example Parkinson’s disease (PD). Traditionally, gait data of standardized tests in the clinic is analyzed, ensuring a predefined setting. In recent years, long-term home-based gait analysis has been used to acquire a more representative picture of the patient’s disease status. Data is recorded in a less artifical setting and therefore allows a more realistic perception of the disease progression. However, fully unsupervised gait data without additional context information impedes interpretation. As an intermediate solution, performance of gait tests at home was introduced. Integration of instrumented gait test requires annotations of those tests for their identification and further processing. To overcome these limitations, we developed an algorithm for automatic detection of standardized gait tests from continuous sensor data with the goal of making manual annotations obsolete. The method is based on dynamic time warping, which compares an input signal with a predefined template and quantifies similarity between both. Different templates were compared and an optimized template was created. The classification scored a F1-measure of 86.7% for evaluation on a data set acquired in a clinical setting. We believe that this approach can be transferred to home-monitoring systems and will facilitate a more efficient and automated gait analysis.
|
2022-11-27T17:54:40.337Z
|
3,096,114 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICCVW.2009.5457526",
"MAG": "1970645982",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We address the person-independent recognition problem of facial expressions using static 3D face data. The novel approach to the facial expression recognition uses non-rigid registration of surface curvature features. 3D face data is cast onto 2D feature images, which are then subjected to elastic deformations in their parametric space. Each Action Unit (AU) detector is trained over its respective influence domain on the face. The registration task is incorporated in the multiresolution elastic deformation scheme, which yields adequate registration accuracy for mild pose variations. The algorithm is fully automatic and is free of the burden of first localizing anatomical facial points. The algorithm was tested on 22 facial action units of Facial Action Coding System. Promising results obtained indicate that we have an operative device for facial action unit detection, and an intermediate step to infer emotional or mental states. Moreover, experiments conducted with low intensity AU12 - Lip Corner Puller points to the potential of 3D data and the proposed method in subtle expression detection.
|
2022-12-13T21:41:09.226Z
|
159,367,690 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5753/wtrans.2018.3097",
"MAG": "2914901062",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://sol.sbc.org.br/index.php/wtrans/article/download/3097/3059"
}
|
A internet renovou a forma como a comunicação e o acesso às informações de saúde são feitos. Porém, a internet está sujeita a dificuldades referentes à busca e qualidade da informação sobre saúde. A Transparência é uma demanda atual da sociedade, e o fornecimento de informações de saúde mais transparentes vai de encontro às tecnologias como a internet como um item de qualidade. O problema abordado neste trabalho está relacionado com a busca e com o acesso a informação de boa qualidade em saúde disponível na internet. Afim de tratar esta questão, uma abordagem baseada na identificação, seleção e consolidação de informações foi proposta. Tal abordagem culminou no desenvolvimento de um protótipo, que foi utilizado em uma avaliação preliminar, cujos resultados são descritos.
|
2022-12-12T03:09:50.938Z
|
7,451,637 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4161/cc.6.2.3758",
"MAG": "2086785163",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.tandfonline.com/doi/pdf/10.4161/cc.6.2.3758?needAccess=true"
}
|
Until recently, the connection between aging and DNA repair has rested on two classes of observation. First, DNA damage and unrepaired double-strand breaks (DSBs) accumulate with age. Second, several defects in DNA repair genes are associated with early onset of age-related diseases and other signs of premature aging. Now, a third link has emerged: The mechanisms by which cells repair DSB damage can change dramatically with age, shifting from simpler end-joining processes in younger organisms to homologous mechanisms in which missing genetic information is restored through use of a template. So far this third link between aging and DNA repair has only been observed in a small number of experimental systems, and cannot yet claim the generality of the other two. Here we review the evidence for this phenomenon and present new data testing models for the underlying causes. If the generality of age-related changes in DSB repair pathway usage can be established, it will provide a new insight into the underlying molecular basis of aging and how evolution has shaped these processes.
|
2022-12-18T17:07:50.153Z
|
11,020,980 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IPDPS.2010.5470484",
"MAG": "2139973861",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Determinant Quantum Monte Carlo (DQMC) simulation has been widely used to reveal macroscopic properties of strong correlated materials. However, parallelization of the DQMC simulation is extremely challenging duo to the serial nature of underlying Markov chain and numerical stability issues. We extend previous work with novelty by presenting a hybrid granularity parallelization (HGP) scheme that combines algorithmic and implementation techniques to speed up the DQMC simulation. From coarse-grained parallel Markov chain and task decompositions to fine-grained parallelization methods for matrix computations and Green's function calculations, the HGP scheme explores the parallelism on different levels and maps the underlying algorithms onto different computational components that are suitable for modern high performance heterogeneous computer systems. Practical techniques, such as communication and computation overlapping, message compression and load balancing are also considered in the proposed HGP scheme. We have implemented the DQMC simulation with the HGP scheme on an IBM Blue Gene/P system. The effectiveness of the new scheme is demonstrated through both theoretical analysis and performance results. Experiments have shown over a factor of 80 speedups on an IBM Blue Gene/P system with 1,014 computational processors.
|
2022-12-19T13:21:36.755Z
|
6,976,882 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/jcm.21.2.226-230.1985",
"MAG": "1587088609",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc271618?pdf=render"
}
|
Four strains of Campylobacter jejuni and four strains of Campylobacter coli were used to compare the quantitative growth of Campylobacter cells on blood agar base no. 2 (Oxoid), brucella agar (BBL Microbiology Systems and Difco Laboratories), campylobacter agar base (Difco), Columbia blood agar base (Difco and Oxoid), and Mueller-Hinton agar (Difco and Oxoid). Columbia blood agar base and blood agar base no. 2 were inhibitory to most of the strains tested, as evidenced by reduced (10- to 1,000-fold) colony counts compared with other basal media. One of the brucella agars was inhibitory to two of the C. coli strains. The inhibitory effect of these media could be eliminated by addition of FBP (0.05% each ferrous sulfate hydrate, sodium metabisulfite, and sodium pyruvate) or 7% defibrinated sheep blood. However, addition of FBP or blood to brucella agar, campylobacter agar base, or Mueller-Hinton agar did not significantly affect the count, indicating that supplements are not required in these media for growth of Campylobacter in pure culture.
|
2022-12-23T02:28:00.455Z
|
11,536,966 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1053/J.GASTRO.2004.08.052",
"MAG": "2151769300",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND & AIMS
Histologic examination of a liver biopsy specimen is regarded as the reference standard for detecting liver fibrosis. Biopsy can be painful and hazardous, and assessment is subjective and prone to sampling error. We developed a panel of sensitive automated immunoassays to detect matrix constituents and mediators of matrix remodeling in serum to evaluate their performance in the detection of liver fibrosis.
METHODS
In an international multicenter cohort study, serum levels of 9 surrogate markers of liver fibrosis were compared with fibrosis stage in liver biopsy specimens obtained from 1021 subjects with chronic liver disease. Discriminant analysis of a test set of samples was used to identify an algorithm combining age, hyaluronic acid, amino-terminal propeptide of type III collagen, and tissue inhibitor of matrix metalloproteinase 1 that was subsequently evaluated using a validation set of biopsy specimens and serum samples.
RESULTS
The algorithm detected fibrosis (sensitivity, 90%) and accurately detected the absence of fibrosis (negative predictive value for significant fibrosis, 92%; area under the curve of a receiver operating characteristic plot, .804; standard error, .02; P < .0001; 95% confidence interval, .758-.851). Performance was excellent for alcoholic liver disease and nonalcoholic fatty liver disease. The algorithm performed equally well in comparison with each of the pathologists. In contrast, pathologists' agreement over histologic scores ranged from very good to moderate (kappa = .97-.46).
CONCLUSIONS
Assessment of liver fibrosis with multiple serum markers used in combination is sensitive, specific, and reproducible, suggesting they may be used in conjunction with liver biopsy to assess a range of chronic liver diseases.
|
2022-12-31T18:03:40.018Z
|
9,349,144 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12968/hmed.2017.78.7.407",
"MAG": "2734609580",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
T his year sees an unusual double anniversary, that of Alexander Monro primus, a founder of the Edinburgh Medical School, who died 250 years ago, and also of his son, Alexander Monro secundus, who succeeded him and who died 50 years later. Alexander Monro primus was born in London in 1697. His father, John, was an army surgeon. In 1700 John Monro resigned from the army and moved to Edinburgh, where he was admitted to the Incorporation of Surgeons and set up in practice. Young Alexander attended the University of Edinburgh from 1710 to 1713, before becoming apprenticed to his father. In 1717, Alexander travelled to London to attend the anatomy course of that distinguished surgeon William Cheselden, then on to Paris in 1718, followed by a year at Leiden, studying clinical medicine under the great Herman Boerhaave. During this time he also visited Frederick Ruysch in Amsterdam, from whom he learned the art of the preparation of anatomical specimens. In passing, it is interesting that in those days keen postgraduates and students often undertook considerable difficult and expensive journeys abroad to study under the great teachers of the time. Latin was the lingua franca which made communication easy. Monro returned to Edinburgh in 1719 and in January 1720 was appointed to the vacant chair of anatomy, now defined as a University chair. This appointment is now regarded as marking the beginning of the Edinburgh Medical School. Monro’s lecture courses ran from October to April each year – the summer months made teaching on unpreserved cadavers too odoriferous and dangerous. The course commenced with the history of anatomy, then went on to human anatomy, comparative anatomy, physiology and operative surgery. As well as human dissections, animals and wax models were used. By 1751 the class numbers had grown from 57 students to an annual entry of 200. In 1726, Monro published his only textbook The Anatomy of the Human Bones. The second edition added material on the nerves, heart and the lacteals. It remained a popular book for the next 100 years. In 1729, Monro rented a house with six beds for the sick poor to provide clinical training for medical students. It was chartered by King George II as The Royal Infirmary in 1736 – the beginning of today’s famous institution.
|
2022-02-13T07:34:13.172Z
|
196,704,010 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/CHIN.201034076",
"MAG": "1967105276",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Various aldehydes can be converted to highly functionalized δ-amino-α,β-unsaturated carboxylic esters with good to excellent enantioselectivity and complete regioselectivity.
|
2022-02-08T07:01:07.424Z
|
233,337,064 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/s1743921308023958",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.cambridge.org/core/services/aop-cambridge-core/content/view/17E4826A5CBD663916BF6525C10F2DA0/S1743921308023958a.pdf/div-class-title-commission-27-variable-stars-div.pdf"
}
|
The meeting started at 16h00. The president welcomed the 24 participants to the business meeting of Commission 27. After the approval of the agenda, she gave an overview of the activities of Commission 27 of the past three years.
|
2022-07-10T03:03:34.846Z
|
167,863,069 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5850/JKSCT.2007.31.3.475",
"MAG": "2019883120",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purposes of this study were to examine attitudes toward countefeits among fashion luxury brand consumers, and to investigate the influences or effects of brand loyalty on purchasing frequency of fashion luxury brand and the effects of brand loyalty on attitudes toward counterfeits. The subject used for this study were 214 female consumers who have purchased fashion luxury brand products. For data analysis, descriptive statistics, factor analysis, multiple regression, and ANOVA were used. As the results, first, the brand loyalty were classified into three factors; enduring brand loyalty, symbolic brand loyalty and famous brand loyalty. Second, the attitudes toward counterfeit was composed of four factors; comparison with genuine goods, counterfeits as alternative, approval of counterfeits purchase, and illegality of counterfeit manufacturers. Third, purchasing frequency significantly influenced on the attitudes toward counterfeits finally, higher brand loyalty group had more negative attitudes and lower purchasing intention toward counterfeits than other groups. Based on these results, prevention marketing strategies of counterfeit goods would be provided.
|
2022-08-16T20:26:39.980Z
|
192,989,484 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/bd.1994.28.9.1426",
"MAG": "2333247218",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Die Normierung von Personennamen verfolgt das Ziel, ihre Ansetzung in Bibliothekskatalogen und speziell Verbundsystemen zu vereinheitlichen und ihre Auffindbarkeit in Online-Katalogen für Benutzer (OPAC) über eine Vielzahl von Sucheinstiegen zu erleichtem. Idealerweise werden Normdatensätze so verwaltet, daß der Benutzer über jede Form des Namenssatzes sei es die Ansetzung, sei es eine Verweisungsform mit einer Suche alle mit diesem Datensatz verknüpften Titel ermitteln kann.
|
2022-02-08T08:37:04.210Z
|
123,628,788 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10238169408200026",
"MAG": "2083928918",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Pakistan Research Reactor-1 (PARR-1) is a major facility for research and isotope production at the Pakistan Institute of Nuclear Science and Technology (PINSTECH). The 5 MW materials test reactor (MTR) type swimming pool research reactor achieved criticality in 1965. The reactor was fueled with 93 percent highly enriched uranium (HEU) fuel, and moderated and cooled by light water. A graphite thermal column at one side of the core served as reflector. The layout of experimental facilities around the PARR-1 core is shown in Figure 1 . The layout consists of six radial beam tubes, a tangential through-tube, a graphite thermal column, three pneumatic rabbit stations, a
|
2022-02-09T18:36:15.056Z
|
109,699,410 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11318/MII1984.9.67",
"MAG": "1726059165",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Department of Radiology, Iwate Medical University, Morioka 020, Japan ** Department of Radiological Technology, College of Medical Sciences, Tohoku University, Sendai 980, Japan *** Electrical Engineering, Hachinohe National College of Technology, Hachinohe 039-11, Japan ****Center for Radiological Science, Iwate Medical University, Morioka 020, Japan ***** Department of Radiology, lwate Medical University, Morioka 020, Japan (Received June 8, 1991, in final form November 14, 1991)
|
2022-06-16T11:30:18.959Z
|
2,808,672 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/ssrn.2192045",
"MAG": "1496049285",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://ub-madoc.bib.uni-mannheim.de/32893/1/dp12082.pdf"
}
|
The paper investigates the effects of temporary consumption tax cuts using firm-level data. As
part of its countercyclical measures implemented during the recent global economic crisis, Turkey
temporarily lowered consumption taxes on selected durables. Using data on the change of
sales of firms that benefited from this measure and of those that did not over different periods,
we perform a difference-in-difference analysis where we also control for various unobservable
effects including sector-specific shocks to address potential endogeneity. We find positive and
robust effects of consumption tax cuts on the change of firm sales which is consistent with theoretical
predictions.
|
2022-11-11T08:09:31.550Z
|
30,291,805 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1043/1543-2165(2006)130[975:MIPWTD]2.0.CO;2",
"MAG": "2184565122",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A malpractice suit arises when a patient brings legal charges against a physician for suffering that the patient claims to have endured because the physician failed to provide appropriate care. Suffering usually encompasses a measure of misdiagnosis and of rude treatment of the patient by medical staff. Polite treatment of all patients by all laboratory staff will prevent some disputes from ever forming, thus preventing some charges of malpractice. Even if a patient is treated rudely, that rudeness alone is insufficient to justify a charge of malpractice. Attorneys must follow legal guidelines to determine whether the physician's actions caused actual damage. As soon as a physician is served notice of a lawsuit, the physician must notify the office that insures him or her against claims of malpractice (eg, the office of risk management or the physician's malpractice insurance carrier). Being sued creates an overwhelming urge to talk about the case, but a physician who has been sued must not talk to anyone about the lawsuit or the case involved. Conversations about the lawsuit may only safely be had with the attorney who will defend the physician against the charge of malpractice. Despite any frustrations with the legal system, the physician must work with and even trust the attorney handling the defense. It is possible to overcome a charge of malpractice, but not if the physician creates an indefensible situation by committing fraud. Examples of fraud are changing the medical record or destroying the pertinent microscope slide.
|
2022-12-11T12:10:48.423Z
|
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