corpusid
int64 5
255M
| openaccessinfo
dict | abstract
stringlengths 1
10k
| updated
stringlengths 20
24
|
|---|---|---|---|
235,785,750 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/den.14065",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Figure 1 (a) Computed tomography image of a patient who underwent pancreatobiliary endoscopic ultrasound (EUS) reveals a large periampullary diverticulum (asterisk). (b) Endoscopic image of the periampullary diverticula and the papilla (arrowhead). (c, d) EUS image shows that air trapped in periampullary diverticula disturb acoustic coupling, and delineating the biliary duct and pancreatic duct (arrow) was difficult.
|
2022-11-11T08:18:31.168Z
|
253,148,602 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/su142113698",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2071-1050/14/21/13698/pdf?version=1666749504"
}
|
Safety risk identification is the premise and foundation of safety risk management for railway construction. However, due to some characteristics of railway projects, which include large volumes of work, complex construction environments, and long construction cycles, etc., the risk factors of railway projects are often hidden in all stages of engineering construction. It results in the comprehensive identification of safety risks of railway projects being usually difficult, and this problem is more serious when the railway is constructed in complex and dangerous areas. Therefore, to identify the safety risks comprehensively, this paper constructs a safety risk identification method applicable to railway construction in complex and dangerous areas. This method studies the spatial and temporal distribution of risks and their relationship with subprojects by using a work breakdown structure (WBS), a risk breakdown structure (RBS), grid-based management, and forming a safety risk identification matrix, which can help researchers analyze the characteristics of risks. In order to verify the effectiveness of the method, the A Railway, which is located in the western of China, was selected as a case study, and risk identification for its civil engineering was carried out. The research results show that in the construction process of the A Railway, the main types of safety risks suffered by various branch projects were different. In addition, some risk factors only appeared at specific times in space, and there is a strong interaction between these risk factors. Based on this method, safety risk identification can intuitively discover the spatial and temporal distribution of risk factors and analyze the interaction between risk factors, which can provide help for the formulation of targeted risk control measures.
|
2022-11-11T08:05:11.689Z
|
211,160,557 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1096/fj.201903117R",
"MAG": "3008934604",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Excessive proliferation and apoptosis‐resistance are hallmarks of cancer. Increased dynamin‐related protein 1 (Drp1)‐mediated mitochondrial fission is one of the mediators of this phenotype. Mitochondrial fission that accompanies the nuclear division is called mitotic fission and occurs when activated Drp1 binds partner proteins on the outer mitochondrial membrane. We examine the role of Drp1‐binding partners, mitochondrial dynamics protein of 49 and 51 kDa (MiD49 and MiD51), as drivers of cell proliferation and apoptosis‐resistance in non‐small cell lung cancer (NSCLC) and invasive breast carcinoma (IBC). We also evaluate whether inhibiting MiDs can be therapeutically exploited to regress cancer. We show that MiD levels are pathologically elevated in NSCLC and IBC by an epigenetic mechanism (decreased microRNA‐34a‐3p expression). MiDs silencing causes cell cycle arrest through (a) increased expression of cell cycle inhibitors, p27Kip1 and p21Waf1, (b) inhibition of Drp1, and (c) inhibition of the Akt‐mTOR‐p70S6K pathway. Silencing MiDs leads to mitochondrial fusion, cell cycle arrest, increased apoptosis, and tumor regression in a xenotransplant NSCLC model. There are positive correlations between MiD expression and tumor size and grade in breast cancer patients and inverse correlations with survival in NSCLC patients. The microRNA‐34a‐3p‐MiDs axis is important to cancer pathogenesis and constitutes a new therapeutic target.
|
2022-12-14T07:52:44.102Z
|
121,445,870 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/AO.3.000229",
"MAG": "2049488757",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The infrared transmittance of water vapor has been calculated over a wide range of path lengths, pressures, and temperatures. All contributing lines whose relative intensity is greater than 10−8 times that of the strongest line in any particular band have been included in the calculation. In addition, the contributions from the four major isotopic species have been included. Although the vibrational analysis has been done exactly, the rotational contributions for some of the weaker lines have been calculated from the symmetric rotator approximation. This approximation was not used for the frequencies and intensities of the stronger lines below 3400 cm−1 which are correctly included in the calculations. The final transmittance tables have been generated using the quasi-random model of molecular band absorption.
|
2022-12-17T11:00:25.563Z
|
31,548,005 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/s-0043-123934",
"MAG": "2782734498",
"PubMedCentral": "5770265"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-123934.pdf"
}
|
Background and study aims Endoscopic nasobiliary drainage (ENBD) for a malignant stricture in the bile duct has some advantages over endoscopic biliary stenting (EBS). However, ENBD may cause nasopharyngeal discomfort. We developed an external-to-internal convertible endoscopic biliary drainage (ETI-EBD) device that enables both internal and external drainage to occur during a single endoscopy. Patients and methods This device consists of three parts, comprising a 5-Fr ENBD tube (250 cm) (ENBD-t), an 8.5-Fr EBS tube (7 cm) (EBS-t), and an 8-Fr pusher tube for EBS (230 cm) (P-t). The EBS-t is mounted over the ENBD-t at the distal end of the ENBD-t. The P-t is also placed over the ENBD-t. After an endoscopic sphincterotomy, the EBS-t of the device is inserted into the papilla, then the duodenal endoscope is withdrawn, leaving the device in place. After ENBD, only the ENBD-t was withdrawn from the P-t. At this point, the EBS-t was isolated and left without endoscopy or radiography. Results ETI-EBD was successfully placed in all consecutive 21 patients (100 %). The release of EBS-t from ENBD-t wit was successfully completed in 19 patients (90.5 %). There were 4 patients with kink of P-t when exchanging this device from the mouth to the nose. It was difficult for 2 patients to withdraw the ENBD-t because of poor lubrication performance. There were no significant complications associated with the use of the device. Conclusion This device allows for both external and internal biliary drainage with a single endoscopy.
|
2022-12-17T22:49:34.384Z
|
17,566,334 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0037549704046339",
"MAG": "1989439555",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Modelling of thermofluid systems is complex because of the coupling of thermal and hydraulic energies. Bond graph language is a suitable tool for modelling such nonlinearmultienergy domain systems along with their control systems. Structural control properties of the system can be determined using the causal properties of bond graphs, without resorting to any formal computation. An ontology for classifying thermofluid process components is presented in this article, along with connection syntax and model validation algorithms. Then the theory for structural analysis is used to design sensor placements for observability and also for component fault detection and isolation. This study also deals with developing a bond graph–based model representation mechanism to perform structurallevel linking of submodels.The methodology developed is applied to two example systems. Simulation of process faults is used to validate the theoretically obtained fault signatures for a thermofluid system in the second example.
|
2022-12-17T23:18:52.238Z
|
147,472,384 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/s0140525x10002360",
"MAG": "2317998211",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://philpapers.org/archive/MANWIT-3.pdf"
}
|
Abstract It's unclear what narrow content is interpersonally shared for concepts that don't originate from core cognition yet are still definitionally and interpretationally primitive. A primary concern is that for these concepts, one cannot draw a principled distinction between inferences that are content determining and those that aren't. The lack of a principled distinction imperils an account of interpersonally shared concepts.
|
2022-12-23T02:21:54.620Z
|
236,437,417 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fonc.2021.713346",
"MAG": null,
"PubMedCentral": "8353455"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fonc.2021.713346/pdf"
}
|
To identify novel hypoxia-associated long non-coding RNAs (lncRNAs) as potential biomarkers, we developed a risk stratification signature and constructed a prognosis prediction nomogram of clear cell renal cell carcinoma (ccRCC). Hypoxia-related lncRNAs were identified through Pearson correlation analysis between the expression profiles of hypoxia-related differentially expressed genes and lncRNAs from The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) dataset. Then, a signature of four key lncRNAs (COMETT, EMX2OS, AC026462.3, and HAGLR) was developed. The four lncRNAs were downregulated in high-grade, advanced stage, and high-risk ccRCC. The signature had an independent and long-standing prognosis prediction ability up to a 10-year follow-up. Notably, the risk score was significantly positively correlated with the infiltration abundances of six immune cells from the Tumor IMmune Estimation Resource (TIMER). The gene set enrichment analysis (GSEA) also suggested that the signature was involved in metabolism and tumorigenesis, which were closely related to the hypoxic tumor microenvironment. Ultimately, a nomogram of signature, age, stage, and grade, was built to predict the individual long-term survival possibility. Finally, the expressions of four lncRNAs were validated by quantitative real-time PCR (qRT-PCR). Our study identified a four-lncRNA signature and established a prognostic nomogram that reliably predicts survival in ccRCC. The findings may be beneficial to therapeutic customization and medical decision-making.
|
2023-01-01T17:50:18.923Z
|
159,358,954 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31188/CAJSM.2(2).2018.R143",
"MAG": "2914578436",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cette contribution examine la couverture journalistique de l’annee 2008 en ce qui a trait aux domaines du livre et des bibliotheques. En tenant compte du contexte quebecois, ou la presse contribue a la democratisation culturelle, nous desirons comprendre la maniere dont sont traites ces deux domaines dans les journaux. Les analyses qualitatives et quantitatives d’articles de presse permettent de constater que les thematiques traitees par les journalistes culturels sont generalement tributaires de l’actualite et qu’une reelle posture critique est rarement adoptee. Nous remarquons egalement une couverture journalistique contrastee entre les deux domaines etudies sur le plan des intentions journalistiques et des criteres de valorisation mis de l’avant. Aussi les articles contribuent-ils davantage au succes commercial de l’industrie du livre qu’au developpement des pratiques citoyennes face au livre et aux bibliotheques.
|
2022-06-07T22:00:34.551Z
|
146,363,009 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24850/J-TYCA-2019-03-02",
"MAG": "2936481786",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the last three decades, Mexican water management policy has been reformed to include the participation of social actors in the decision-making process. Nonetheless, water governance receives intense criticism from those who consider that this participatory approach has decreased the efficiency in decision-making and others who believe that public participation is not efficiently included. To clarify this debate, we identify the fundamentals, the obstacles, and the challenges of the public involvement in water management through a systematic review of the literature. We found that the restrictions of such involvement are most likely associated with: 1) characteristics and context of the participants; 2) different levels of information and power; 3) institutional arrangement and rules of the process; 4) the lack of resources to participate, and 5) the lack of motivation and political will. The most critical challenges are: a) decentralization; b) the combination of technical and non-technical knowledge; c) the strengthening of capacities for participation, and d) the influence of the government in the decision-making process. With these elements, we elaborate an analytical framework and come up with the recommendations to improve public participation in water management in Mexico.
|
2022-09-06T18:03:25.240Z
|
45,750,061 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1192/BJP.108.454.371",
"MAG": "1973355206",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Foiu@i@attempts to restore weight loss in psychiatric patients have included hyperalimentation (Weir Mitchell, 8) and sub-coma insulin therapy (Debenham et a!., 2 ; Sargant and Craske, 5 ; Sullivan, 7). The aim of the present trial was to compare weight gains in a group of patients given repeated small doses of in sulin with two other groups to whom oral hypoglycaemic agents were admiis tered, and with a control group. The drugs used were tolbutamide and chior propamide, both of which are suiphonylureas used in the management of diabetes meffitus, and known to induce hypoglycaemia in non-diabetic subjects (Hoenig and Gittleson, 4; Cardonnet et a!., 1; Garcia Reyes et a!., 3). Pharma cologically there are no qualititative differences in their mode ofaction. Stowers et a!., (6) found the half-life of tolbutamide to be 3 †̃¿ 5 hours and that of chlor propamide 34 †̃¿ 5 hours. The prolonged action of chiorpropamide permits once daily dosage, but tolbutamide, being a shorter acting drug, was given in divided doses to maintain depression of blood sugar over the 24 hours. The subjects were in-patients in a general hospital psychiatric unit who had suffered weight loss prior to admission. As the average length of stay in this unit is four weeks, patients could not serve as their own controls. The trial comprised 42 patients, 31 women and 11 men, with an age range of 23 to 68 years. Patients were allocated to the four groups at random. No selection on clinical grounds was made except that patients suffering from serious physical disease were excluded. Weighing took place at the start of the trial and thereafter twice weekly, patients being weighed in the same night attire on each occasion. The weights were checked by two nurses. Patients were not told of the nature or purpose of the medication. Each patient's fasting blood sugar was examined before starting the trial; in all cases levels were normal. The insulin group (3 men, 8 women) commenced with 5 units of soluble insulin 30 minutes before each of the three main meals, with daily increases up to 10 units, if tolerated; the tolbutamide group (3 men, 7 women) were given 1 †̃¿ 0 gram of the drug 30 minutes before main meals; the chlorpropamide group (3 men, 8 women) were given 0'S gram of the drug at 6.30 a.m. each day. The control group consisted of 2 men and 8 women. The patients also received appropriate physical and psychotherapeutic measures: 34 received ECT, 18 modified narcosis, 14 phenothiazines and 2 Tofranil. Diagnostic categories in cluded: affective psychosis (16 patients), personality disorder (11), and abnormal psychogenic reactions (15). The four treatment groups were statistically com pared in respect to age, length of stay, diagnosis, “¿ other treatments given―, and psychiatric outcome. All significance tests were made at the P=0 †̃¿ 05leveL There were no significant differences between the groups.
|
2022-02-12T00:12:49.527Z
|
72,760,122 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/BJSM.13.2.80",
"MAG": "2082356277",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Durrant, E., 1975. "The effects of jogging, rope jumping, and aerobic dance on body composition and maximum oxygen uptake of college females", Doctoral dissertation, Brigham Young University. Ekblom, E. and Goldbarg, A. N., 1971. "The influence of training and other factors on the subjective rating of perceived exertion", Acta Physiologica Scandinavica, 83: 399-406. Edwards, M. A., 1974. "The effects of training at predetermined heart rate levels for sedentary college women", Med.Science Sports, 6: 14-19. Eisenman, P. A. and Golding, L. A., 1975. "Comparisons of effects of training on V02 max in girls and young women", Med.Science Sports, 7: 135-138. Flint, M. M., Drinkwater, B. L. and Howarth, S. M., 1974. "Effects of training on women's response to submaximal exercise", Med.Science Sports, 6: 89-97. Foster, C., 1975. "Physiological requirements of aerobic dancing", Research Quart. 46: 120. Maas, S. H., 1975. "A study of the cardiovascular training effects of aerobic dance instruction among college age females", Masters thesis, North Texas State University. Metheny, E., 1965. Connotations of movement in sport and dance, W. C. Brown Co., Dubuque, Iowa. Patton, J. F., Morgan, W. P. and Vogel, J. A., 1977. "Perceived exertion of absolute work during a military physical training program", European Journal of Applied Physiology, 36: 107-114. Sorensen, J., 1974. "Aerobic dancing, what's it all about?", Fitness for Living, 8: 18. Sorensen, J., 1972. Jackie's Aerobic Dancing, Scott, Foresman and Company, Dallas. Walker, N. D., 1976. "A comparison of perceived exertion ratings of aerobic dance and treadmill performances among college age males and females", Master's thesis, North Texas State University. Weber, H., 1974. "The energy cost of aerobic dancing", Fitness for Living, 8: 26. Zohman, L. R. and Phillips, R. E., 1973. Medical Aspects of Exercise Testing and Training. Intercontinental Medical Book Corp, New York City.
|
2022-04-08T01:19:40.544Z
|
97,345,989 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.371845",
"MAG": "2057470536",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
CsBr doped with Ga+ has previously proved to be an efficient X-ray storage phosphor with a figure of merit comparable to that of the commercially used BaFBr:Eu2+. By measuring the magnetic circular dichroism of the optical absorption (MCDA), the MCDA-detected electron paramagnetic resonance and the photostimulated luminescence (PSL), the paramagnetic defect centers generated upon x-irradiation involved in the storage and read-out process were investigated and found to be particularly simple: The electron traps are F centers, the hole trap centers are Ga2+ centers with a hyperfine interaction with 69Ga of 69A=6.5 GHz. No superhyperfine interaction was resolved. It is proposed that the PSL-active Ga2+ center is an isolated Ga2+ on a Cs+ site.
|
2022-09-23T03:56:42.395Z
|
123,635,205 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/17445300902781393",
"MAG": "2082848615",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper deals with the numerical realisation of the wave-source identification of wavemaker by measuring the radiated waves caused by the wavemaker. The problem is governed by the Fredholm type of integral equation of the first kind, resulting in numerical instability of solution. In order to overcome the difficulty of numerical instability, Landweber regularisation method (stable numerical algorithm) is introduced in this paper. The result of the present study can be applied to the radiation problem for an oscillating ship.
|
2022-11-30T18:15:37.087Z
|
253,058,805 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01496395.2022.2135541",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT In the present investigation, we describe a rapid and eco-friendly mechanochemical method that completely avoids the use of corrosive acids for the synthesis of carboxy-rich-polyaniline decorated MCNTs composite (cPANI@MCNTs) at room temperature as an efficient adsorbent for the removal of cationic methylene blue (MB) and methyl violet (MV) dyes from water. The intrinsic physico-chemical properties of newly synthesized materials were characterized by using FTIR, XRD, SEM, and EDX analytical techniques. To ascertain the effects of adsorbent dose, contact time, and pH of the medium on the adsorption process, batch adsorption studies were conducted. It was discovered that pH values of 7 and above are the most favorable for cationic dye adsorption onto cPANI@MCNTs. The adsorption equilibrium data for the dye adsorption process fitted well with the Langmuir model of adsorption and adsorption kinetics disclosed that the data are in excellent agreement with R2 values of 1 (MB) and 0.99996 (MV) for the pseudo-second-order. The adsorption of dyes on cPANI@MCNTs from thermodynamic data was found to be spontaneous and endothermic in nature. The results indicate that the composite demonstrated admirable maximum adsorption capacity toward both MB (194.9 mg g −1) and MV (122.5 mg g −1) signifying cPANI@MCNTs as an efficient cationic-dye adsorbent. GRAPHICAL ABSTRACT
|
2022-12-29T18:19:51.804Z
|
119,487,711 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.552037",
"MAG": "1968300026",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://vtec.ess.sci.osaka-u.ac.jp/%7Ehayasida/Study/XIS2/XIS2_softxraycal_2004SPIE.pdf"
}
|
We present the current status of soft X-ray calibration of X-ray CCD cameras, X-ray Imaging Spectrometer (XIS), onboard Astro-E2. We perform soft X-ray calibration of four front illuminated (FI) CCD cameras and two back illuminated (BI) CCD cameras, among which four cameras will be selected to be installed on the satellite. The calibration aims to measure the quantum efficiency and re-distribution function of the CCDs as a function of incident X-ray energy. A soft X-ray spectrometer is used to measure these items. In addition, we employ a gas proportional counter and an XIS engineering unit as reference detectors for the quantum efficiency measurement. We describe how we calibrate the absolute quantum efficiency of the XIS using these instruments. We show some of the preliminary results of the calibration including quick look results of BI CCD cameras.
|
2022-07-23T09:21:36.176Z
|
16,638,773 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SSP.2012.6319717",
"MAG": "2018134780",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We analyze the convergence rates of composite gradient methods for solving problems based on regularized M-estimators, working within a high-dimensional framework that allows the data dimension d to grow with (and possibly exceed) the sample size n. This high-dimensional structure precludes the usual global assumptions-namely, strong convexity and smoothness conditions-that underlie much of classical optimization analysis. We define appropriately restricted versions of these conditions, and show that they are satisfied with high probability for various statistical models. Under these conditions, our theory guarantees that composite gradient descent has a globally geometric rate of convergence up to the statistical precision of the model, meaning the typical distance between the true unknown parameter θ* and an optimal solution θ̂. This result is substantially sharper than previous results, which yielded sublinear convergence or linear convergence up to the noise level, and builds on our earlier work for constrained estimation problems. Our analysis applies to a wide range of M-estimators and statistical models, including sparse linear regression using Lasso (ℓ1-regularized regression); group Lasso for block sparsity; log-linear models with regularization; low-rank matrix recovery using nuclear norm regularization; and matrix decomposition. Overall, our analysis reveals interesting connections between statistical precision and computational efficiency in high-dimensional estimation.
|
2022-09-12T23:16:28.343Z
|
12,816,301 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/07357900903405918",
"MAG": "1965941075",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc3196322?pdf=render"
}
|
ABSTRACT Introduction: The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. Methods: One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. Results: The median normal MnSOD expression was 42% with a range of 10 to 70%, which was significantly greater (p = .001) than the median MnSOD expression in the tumor samples that was 18.8% and ranged from 1.1 to 50%. Conclusion: MnSOD expression is significantly reduced in lung adenocarcinoma and squamous cell carcinoma compared to the matched normal lung tissue.
|
2022-12-18T01:52:34.302Z
|
9,121,132 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1242/jeb.00770",
"MAG": "2135348403",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
SUMMARY Recent studies of vocal mechanics in songbirds have identified a functional role for the beak in sound production. The vocal tract (trachea and beak) filters harmonic overtones from sounds produced by the syrinx, and birds can fine-tune vocal tract resonance properties through changes in beak gape. In this study, we examine patterns of beak gape during song production in seven species of Darwin's finches of the Galápagos Islands. Our principal goals were to characterize the relationship between beak gape and vocal frequency during song production and to explore the possible influence therein of diversity in beak morphology and body size. Birds were audio and video recorded (at 30 frames s–1) as they sang in the field, and 164 song sequences were analyzed. We found that song frequency regressed significantly and positively on beak gape for 38 of 56 individuals and for all seven species examined. This finding provides broad support for a resonance model of vocal tract function in Darwin's finches. Comparison among species revealed significant variation in regression y-intercept values. Body size correlated negatively with y-intercept values, although not at a statistically significant level. We failed to detect variation in regression slopes among finch species, although the regression slopes of Darwin's finch and two North American sparrow species were found to differ. Analysis within one species (Geospiza fortis) revealed significant inter-individual variation in regression parameters; these parameters did not correlate with song frequency features or plumage scores. Our results suggest that patterns of beak use during song production were conserved during the Darwin's finch adaptive radiation, despite the evolution of substantial variation in beak morphology and body size.
|
2022-12-20T04:57:47.619Z
|
145,773,691 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/GPS.930080713",
"MAG": "2098907910",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article details the results of a retrospective case note study on deliberate self‐harm in the elderly in the London Borough of Tower Hamlets. There were 56 females and 32 males included in the study. The ages of the patients ranged from 65 to 90. Fifty‐seven per cent of the sample had a depressive illness, most commonly found in the younger females and the older males. Over 50% of the sample had evidence of multiple health problems, particularly heart disease and arthritis. Over 90% of cases used self‐poisoning as the means of self‐harm. Sixty‐one per cent used benzodiazepines and 25% salicylates. Over 30% used multiple drug combinations. Thirty‐eight per cent of the sample had evidence of previous self‐harm, 17% had repeated self‐harm within a year and 6% were dead through suicide. Although the characteristics of the patients bore some resemblance to those identified in the literature as being risk factors for self‐harm among younger patients, they bore a much closer resemblance to known risk factors for suicide. This may have ramifications for further research into the prevention of suicide.
|
2022-12-20T09:21:19.720Z
|
40,156,059 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/jama.1995.03530120023018",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Association of State and Territorial Public Health Laboratory Directors, CDC, the Food and Drug Administration, the National Institutes of Health, the Council of State and Territorial Epidemiologists, and the National Committee for Clinical Laboratory Standards cosponsored the Second National Conference on Serologic Diagnosis of Lyme Disease held October 27-29, 1994. Conference recommendations were grouped into four categories: 1) serologic test performance and interpretation, 2) quality-assurance practices, 3) new test evaluation and clearance, and 4) communication of developments in Lyme disease (LD) testing. This report presents recommendations for serologic test performance and interpretation, which included substantial changes in the recommended tests and their interpretation for the serodiagnosis of LD.
|
2022-12-31T18:10:38.670Z
|
74,058,470 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/ANNONC/MDU436.19",
"MAG": "2290145732",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Background: Hormone receptor positive, HER2 negative (HR + /HER2-) is the most popular subtype in breast cancer. For HR + /HER2- stageIV patients, endocrine therapy is the first recommended regimen if it is not life-threatening disease, however there are few reports which demonstrated the predictive factors in this setting. The aim of this study is to evaluate the clinical outcome in HR + / HER2- stage IV breast cancer patients who received endocrine therapy for the first-line treatment to find the predictive factors for good response. Methods: Retrospectively, we reviewed HR + /HER2- stage IV breast cancer patients who started for the first-line regimen with endocrine therapy between 2005 and 2010. Results: Fifty-five patients were diagnosed with stageIV breast cancer in the period. Seven patients with bilateral breast cancer and eight patients who underwent no systemic therapy due to their severe condition, fifteen patients with other subtypes (HR- and/or HER2+) and seven HR + /HER2- patients started with chemotherapy were excluded from analysis, so finally 18 patents were reviewed in this study. The median age was 62.5 years and pre- and post- menopausal distribution was four and fourteen, respectively. Bone and/or lymph node metastasis only was found in 9 cases, and the other 9 cases found visceral metastasis. The patients who achieved longer first-line endocrine treatment duration tended to have longer duration with second- and third-line with hormonal drug and estrogen receptor highly positive (90% Conclusions: As to the hormone treatment for HR + /HER2- stageIV breast cancer patients who have no visceral crisis, the patients with highly ER expressive tumor will be expected to treat effectively with endocrine therapy, but the patients with moderate to poorly ER expressive tumor might need to have another strategy rather than endocrine treatment alone.
|
2022-02-11T08:28:08.411Z
|
102,293,739 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2116/BUNSEKIKAGAKU.46.711",
"MAG": "2313213824",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
不均一系液相化学発光反応の場としての塩基性金属過酸化物固体(MgO2,BaO2)の有用性を,ルミノール及びルシゲニン化学発光反応を用いてバッチ法により検討した.その結果,MgO2にルミノール水溶液を,BaO2にルシゲニン水溶液を加えるだけで十分な発光が得られた.過酸化水素を用いるアルカリ溶液中での化学発光反応と比較して化学発光特性は大きく異なり,中性から酸性領域で強い発光が認められた.又,遷移金属イオン触媒の効果はルシゲニンCLにはほとんどなかったが,Cr3+,Mn2+,Cu2+等はルミノールCLを抑制した.ルミノール/MgO2系とルシゲニン/BaO2系とでは発光反応の挙動が異なり,それは金属過酸化物上に存在する活性酸素種の違いに基づくものと推測された.最適な条件下でのルミノールの検出下限は3×10-11Mであり,ルシゲニンの検出下限は3×10-12Mであった.MgO2及びBaO2がアルカリや酸化剤を必要としない化学発光反応場として利用できることが分かった.
|
2022-06-01T12:29:13.267Z
|
30,117,788 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmj.2.5401.116",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This year's open day at the Medical Research Council's centre at Mill Hill for medical and scientific correspondents on 1 July followed the admirable pattern set last year.' After a brief outline of the institute's work by its director, Dr. P. B. MEDAWAR, F.R.S., four short lecture-demonstrations on widely different subjects were given. After lunch those who wished to see more of this work or to discuss it further were able to return, while the heads of all the divisions were " at home" for informal visits by correspondents.
|
2022-07-10T03:03:20.652Z
|
2,452,984 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1152/jn.00284.2009",
"MAG": "2097845407",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
We investigated the nature of the control mechanisms at work during goal-oriented locomotion. In particular, we tested the effects of vision, locomotor speed, and the presence of via points on the geometric and kinematic properties of locomotor trajectories. We first observed that the average trajectories recorded in visual and nonvisual locomotion were highly comparable, suggesting the existence of vision-independent processes underlying the formation of locomotor trajectories. Then by analyzing and comparing the variability around the average trajectories across different experimental conditions, we were able to demonstrate the existence of on-line feedback control in both visual and nonvisual locomotion and to clarify the relations between visual and nonvisual control strategies. Based on these insights, we designed a model in which maximum-smoothness and optimal feedback control principles account, respectively, for the open-loop and feedback processes. Taken together, the experimental and modeling findings provide a novel understanding of the nature of the motor, sensory, and "navigational" processes underlying goal-oriented locomotion.
|
2022-12-19T09:10:16.071Z
|
16,806,338 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/jmg.2008.062141",
"MAG": "2136063424",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://epub.ub.uni-muenchen.de/15759/1/intranasal_insulin.pdf"
}
|
Background: The 22q13 deletion syndrome (Phelan–McDermid syndrome) is characterised by a global developmental delay, absent or delayed speech, generalised hypotonia, autistic behaviour and characteristic phenotypic features. Intranasal insulin has been shown to improve declarative memory in healthy adult subjects and in patients with Alzheimer disease. Aims: To assess if intranasal insulin is also able to improve the developmental delay in children with 22q13 deletion syndrome. Methods: We performed exploratory clinical trials in six children with 22q13 deletion syndrome who received intranasal insulin over a period of 1 year. Short-term (during the first 6 weeks) and long-term effects (after 12 months of treatment) on motor skills, cognitive functions, or autonomous functions, speech and communication, emotional state, social behaviour, behavioural disorders, independence in daily living and education were assessed. Results: The children showed marked short-term improvements in gross and fine motor activities, cognitive functions and educational level. Positive long-term effects were found for fine and gross motor activities, nonverbal communication, cognitive functions and autonomy. Possible side effects were found in one patient who displayed changes in balance, extreme sensitivity to touch and general loss of interest. One patient complained of intermittent nose bleeding. Conclusions: We conclude that long-term administration of intranasal insulin may benefit motor development, cognitive functions and spontaneous activity in children with 22q13 deletion syndrome.
|
2022-12-21T15:23:08.953Z
|
17,547,485 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/genes6010001",
"MAG": "2072752570",
"PubMedCentral": "4377830"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2073-4425/6/1/1/pdf?version=1419435418"
}
|
Expression of miRNAs in Neuroendocrine Neoplasms (NEN) is poorly characterized. We therefore wanted to examine the miRNA expression in Neuroendocrine Tumors (NETs), and identify their targets and importance in NET carcinogenesis. miRNA expression in six NEN primary tumors, six NEN metastases and four normal intestinal tissues was characterized using miRNA arrays, and validated by in-situ hybridization and qPCR. Among the down-regulated miRNAs miR-129-5p and the let-7f/let-7 family, were selected for further characterization. Transfection of miR-129-5p inhibited growth of a pulmonary and an intestinal carcinoid cell line. Analysis of mRNA expression changes identified EGR1 and G3BP1 as miR-129-5p targets. They were validated by luciferase assay and western blotting, and found robustly expressed in NETs by immunohistochemistry. Knockdown of EGR1 and G3BP1 mimicked the growth inhibition induced by miR-129-5p. let-7 overexpression inhibited growth of carcinoid cell lines, and let-7 inhibition increased protein content of the transcription factor BACH1 and its targets MMP1 and HMGA2, all known to promote bone metastases. Immunohistochemistry analysis revealed that let-7 targets are highly expressed in NETs and metastases. We found down-regulation of miR-129-5p and the let-7 family, and identified new neuroendocrine specific targets for these miRNAs, which contributes to the growth and metastatic potential of these tumors.
|
2022-12-31T18:40:00.557Z
|
19,508,311 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4236/IJCM.2014.55030",
"MAG": "2103982394",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: In recent decades, the hospital admission
due to heart failure with normal ejection fraction (HFnEF) or diastolic heart
failure has increased particularly in elderly patients. However, sufficient
data regarding prevalence, etiologies and treatment of diastolic heart failure
are not available for Indian population. So, we carried out an observational study to determine clinical profile and
medical therapy for patients experiencing diastolic heart failure.
Methods: This was prospective observational study carried out in rural area of
India for the period of 12 months. All the patients diagnosed with heart
failure with normal ejection fraction were included in the study. If the
patient was having severe anemia (hemoglobin 8.00 g/dl), hemodynamically significant valvular
disease, prosthetic valve replacement, and ventricular pacemaker, they were excluded. Results: A
total of 53 patients diagnosed with HFnEF were included in the study. There
were 24 male patients. Hypertension, CAD and diabetes mellitus were present in 33, 24 and 16
patients respectively. 18 patients developed severe diastolic dysfunction and
more common in female as compared to male (37.9% vs. 33.3%). Most frequently
observed clinical feature was tachycardia (96% cases) followed by pedal edema
(86%). The patients were treated according to underlying cause. Conclusions:
Diastolic heart failure is more common in elderly patients. In Indian population,
diastolic heart failure has been associated with hypertension, diabetes
mellitus and coronary artery diseases in most of the cases.
|
2022-07-22T10:58:06.507Z
|
251,457,348 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25139/jsk.v6i2.4929",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYSA",
"status": "GOLD",
"url": "https://ejournal.unitomo.ac.id/index.php/jsk/article/download/4929/2366"
}
|
LBHM survey on 2019 mentioned that LGBT groups often experience stigma and discrimination. Although it is widely discussed, it is not easy to access information about these groups. Thus, the problem focuses on how the Semarang gay group uses symbolic communication so that the public can see the symbols used by the Semarang gay group to interact and communicate. This research uses a constructivism paradigm with the qualitative descriptive method and Symbolic Convergence as the main theory. As a result, fantasy exchange creates various communication symbols that converge in the form of verbal (effeminate language/oral and written) and non-verbal (object language, action language and sign language) and are mutually agreed upon as identities to form group cohesiveness. Bad experiences such as stigma/discrimination are the basis for creating safe and easy-to-understand communication symbols between members in exchanging messages and meanings that become the group's motives.
|
2022-08-20T11:17:40.421Z
|
235,767,431 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/asia.202100635",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A thermally-induced intramolecular [4+2] cycloaddition reaction of allylamino- or allyloxy-tethered alkylidenecyclopropanes has been reported in this paper, giving a new protocol for the rapid construction of polycyclic skeleton molecules in moderate to excellent yields with a broad substrate scope. On the basis of control experiments and DFT calculations, we disclosed that the reaction proceeded through a [4+2] cycloaddition and trace of water assisted 1,3-H shift processes to give the target product.
|
2022-08-26T12:20:19.547Z
|
219,416,179 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00207721.2020.1756524",
"MAG": "3024627535",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
ABSTRACT A real-world topological network consists of multiple entrances along its source nodes. Routing appropriate percentages of pedestrians from these entrances to the particular available routes with relevant arrival rates will improve the network’s performance. This paper presents a framework for finding the optimal arrival rates of pedestrians from all available entrances and routes to downstream nodes maximising the network’s throughput. The calculation of the arrival rates and movement directions is based on M/G/C/C analytical and simulation models and the network flow model and considers the real distances of the entrances along the source nodes. The framework was tested on the Tuanku Syed Putra Hall, Universiti Sains Malaysia, Malaysia. Extensive analyses of the performances of its available nodes especially on the achievable optimal throughputs were documented and discussed. Quantitative results show that the hall’s throughput is optimised when pedestrians’ arrival rates to all the available entrances and their movement directions are controlled within certain ranges.
|
2022-08-26T17:10:28.256Z
|
59,741,284 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3233/ica-2000-7304",
"MAG": "5422347",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper introduces an original methodology for hazard-free self-timed design, assuming the worst conditions for robustness. Hazards are classified under three types. Equation hazards are eliminated by an optimal covering. A new variable, labeled state-trajectory is proposed: its integrity guarantees immunity to function hazards. The choice of the delay model for implementation guarantees immunity to logic hazards. Signal-transition graph constraints support safe interaction with synchronous processes. The method was applied to the VLSI CMOS implementation of a router for a parallel machine. Specific cells are designed. Measured performances are presented.
|
2022-08-31T22:06:17.571Z
|
209,518,093 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0226306",
"MAG": "2996890036",
"PubMedCentral": "6936789"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226306&type=printable"
}
|
Background Persons experiencing homelessness and vulnerable housing or those with lived experience of homelessness have worse health outcomes than individuals who are stably housed. Structural violence can dramatically affect their acceptance of interventions. We carried out a systematic review to understand the factors that influence the acceptability of social and health interventions among persons with lived experience of homelessness. Methods We searched through eight bibliographic databases and selected grey literature sources for articles that were published between 1994 and 2019. We selected primary studies that reported on the experiences of homeless populations interacting with practitioners and service providers working in permanent supportive housing, case management, interventions for substance use, income assistance, and women- and youth-specific interventions. Each study was independently assessed for its methodological quality. We used a framework analysis to identify key findings and used the GRADE-CERQual approach to assess confidence in the key findings. Findings Our search identified 11,017 citations of which 35 primary studies met our inclusion criteria. Our synthesis highlighted that individuals were marginalized, dehumanized and excluded by their lived homelessness experience. As a result, trust and personal safety were highly valued within human interactions. Lived experience of homelessness influenced attitudes toward health and social service professionals and sometimes led to reluctance to accept interventions. Physical and structural violence intersected with low self-esteem, depression and homeless-related stigma. Positive self-identity facilitated links to long-term and integrated services, peer support, and patient-centred engagement. Conclusions Individuals with lived experience of homelessness face considerable marginalization, dehumanization and structural violence. Practitioners and social service providers should consider anti-oppressive approaches and provide, refer to, or advocate for health and structural interventions using the principles of trauma-informed care. Accepting and respecting others as they are, without judgment, may help practitioners navigate barriers to inclusiveness, equitability, and effectiveness for primary care that targets this marginalized population.
|
2022-12-29T18:33:39.815Z
|
6,901,104 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IWAT.2008.4511362",
"MAG": "2105421364",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, we proposed the RC-CIP method to analyze the dispersive materials. The results shows that the good stability for wide frequency range. However, the calculation accuracy was not investigated as rectangular pulse response in time domain, the reason was that the exact solution of rectangular pulse was difficult to obtain. Furthermore, in this paper, we calculated homogenous dispersive material, but, the CIP method need special treatment at the boundary between different materials. We did not drive the special treatment for boundary. These will be our future works.
|
2022-02-13T09:32:36.861Z
|
207,814,340 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22037/ORLFPS.V5I1.24279",
"MAG": "2977395745",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: The nasal hump is an aesthetic problem for which hump resection can be done through various techniques. In order to prevent improper resection and post-operative deformity, we applied a new measurement instrument during rhinoplasty. Aim: In this study, we aimed to evaluate the outcome of hump resection under a guiding needle. Methods: This report was conducted on 80 candidate patients for nasal hump removal in Loghman Hakim hospital (Tehran, Iran). In the intervention group, hump modification was done by a guided needle while for the control group, eye inspection was used. Patients’ and surgeon’ satisfaction was evaluated after rhinoplasty and 3 months after the procedure. The significant level was considered less than 0.05. Results: All patients completed the course of study. According to nasal inspection and palpation, the surgical results were better in the hump resection with needle guided localization. The patient satisfaction rate was 90% and 70% in the needle guided group and control group respectively (p=0.048). The observed deformities at 3 months after rhinoplasty had no significant differences between the two groups. Conclusion: According to the findings, the needle guided localization method can be better than eye inspection during rhinoplasty for reducing the cartilage portion of nasal hump.
|
2022-03-11T11:19:05.566Z
|
134,964,246 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1755-1315/215/1/012032",
"MAG": "2906258793",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1755-1315/215/1/012032"
}
|
The objective of the research was to study the effect of using azolla as organic fertilizer and plant spacing toward (i) N and P uptake, (ii) soil compaction and (iii) the yield of Pandanwangi rice. The research was conducted using Completely Block Randomized Design (CRBD) with 6 replicates of 2 factors combination. The first factor was doze of Azolla organic fertilizer consisted two levels were 2.5% and 5% of soil weight. The second factor was plant spacing consisted of three levels were 25cm × 25cm, 30cm ×30cm and 40cm × 40cm. Data was analysed by F test and if there were any significant effects then it was continued by using Duncan’n Multiple Range Test (α=5%). The result of this research showed that application of azolla organic fertilizer as much 5% of soil weight was able to increase N uptake and weight of grain per hill. The application of azolla organic fertilizer to all doze treatments was also able to reduce the soil compaction. The largest of plant spacing treatments was able to increase (i) N and P uptake, and (ii) weight of grain per hill.
|
2022-07-21T12:20:19.069Z
|
9,761,291 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.23919/OCEANS.2011.6107278",
"MAG": "1688467379",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
At 9:46:23 pm Pacific Time on March 10, 2011 (05:46:23 UTC on March 11), a magnitude 9.0 earthquake occurred 129 km (80 miles) off the coast of Sendai, a city in Honshu, Japan. The Tōhoku earthquake triggered a catastrophic tsunami that produced an inundation wave height as high as 30 m that propagated throughout the entire Pacific Ocean basin. Deep-ocean Assessment and Reporting of Tsunamis (DART) buoys positioned around the Pacific Ocean provided real-time data of the impending tsunami as it travelled across the ocean towards the U.S. West Coast. Because of this warning, coastal communities in Washington and Oregon were on guard by the time the tsunami hit the West Coast almost 9 hours after the earthquake occurred. Harbors along the Oregon coast, including Depoe Bay, Coos Bay, and Brookings, and in Crescent City, California reported damage to docks and boats in the harbor. In the Pacific Northwest, the Northwest Association of Networked Ocean Observing Systems (NANOOS), the regional association that manages and operates the Regional Coastal Ocean Observing System (RCOOS) for this area of the country as part of the U.S. Integrated Ocean Observing System (IOOS®) enterprise, provided extensive information to the public about the timing, severity, and government agency recommended actions to take as a result of this event. These included Tsunami Evacuation Zones for the Oregon Coast, providing users of the NANOOS Visualization System with easy access to near real-time current, water height, and other information for a wide variety of U.S. IOOS assets, and posting NANOOS Facebook updates regarding the tsunami passage. We discuss the implications of the use of standard (web-based) means of disseminating coastal hazard mitigation information and discuss possible opportunities that social networking technologies present for providing such information as our society increasingly depends on mobile-technologies and applications.
|
2022-09-10T18:51:23.963Z
|
251,152,045 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26505/djm.22026390223",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://djm.uodiyala.edu.iq/index.php/djm/article/download/898/711"
}
|
Background: Irritable bowel syndrome and obesity are two prevalent conditions in our community which may be associated with each other according to some literature. Both have significant impact on the community.Objective: To find the prevalence of irritable bowel syndrome, its association with general and central obesity, as well as to find its sociodemographic characteristics, and effect of some personal health habits on it.Patients and Methods: In this cross-sectional study, a sample of 248 subjects, 105 males and 143 females, who attended two primary health care centers was taken (included healthy looking subjects and patients with irritable bowel syndrome according to Rome IV criteria). Subjects were aged between 18-65 years. Sociodemographic characteristics, personal health habits, central obesity index and body mass index also recorded in the survey. Results: Prevalence of irritable bowel syndrome was 33.5%, male to female ratio was 0.73:1. No significant association was found between irritable bowel syndrome and general or central obesity. Bad sleep pattern was found to have a significant association with the disorder. Conclusion: The study do not find significant association between obesity and irritable bowel syndrome. Keywords: Irritable bowel syndrome, central obesity, Rome IV criteria
|
2022-10-14T01:23:18.954Z
|
182,545,368 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/BIJ-06-2018-0162",
"MAG": "2945464279",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Purpose
Given the competitive environment and complicated relationships in supply chains in the modern era, it is important to take into account internal and external risks. In addition, proper methods must be designed to evaluate these risks correctly. The purpose of this paper is to provide a suitable map based on the artificial neural network technique to assess and classify the risk levels of retailers who have interconnected rules in the downstream of the supply chain.
Design/methodology/approach
In this research, a model for risk assessment with a hexagonal grid and 2D self-organizing map was applied.
Findings
According to the results, the model used in the study can provide a basis for classification of retailers based on the specified risk levels defined by the experts and risk managers of the company. Also with the model’s visual output, managers can have a better understanding of the distribution of the risk level of retailers.
Practical implications
The proposed methodology can be adopted by managers to assess the risk of members involved in the supply chain, helping them to formulate the risk mitigation strategies based on the risk levels.
Originality/value
As a part of the risk management process, organizations can use this developed method to reduce the existing risks imposed by the members or customers on the company.
|
2022-12-19T14:01:39.910Z
|
253,179,694 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/11786329221127150",
"MAG": null,
"PubMedCentral": "9618755"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.1177/11786329221127150"
}
|
Background: People experiencing homelessness have diverse patterns of healthcare use. This study examined the distribution and determinants of healthcare encounters among adults with a history of homelessness. Methods: Administrative healthcare records were linked with survey data for a general cohort of adults with a history of homelessness and a cohort of homeless adults with mental illness. Binary and count models were used to identify factors associated with hospital admissions, emergency department visits and physician visits for comparison across the 2 cohorts. Results: During the 1-year follow-up period, a higher proportion of people in the cohort with a mental illness used any inpatient (27% vs 14%), emergency (63% vs 53%), or physician services (90% vs 76%) compared to the general homeless cohort. People from racialized groups were less likely use nearly all health services, most notably physician services. Other factors, such as reporting of a regular source of care, poor perceived general health, and diagnosed chronic conditions were associated with higher use of all health services except psychiatric inpatient care Conclusion: When implementing interventions for patients with the greatest health needs, we must consider the unique factors that contribute to higher healthcare use, as well as the barriers to healthcare access.
|
2022-12-29T14:28:52.632Z
|
23,310,671 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/NP9904509",
"MAG": "2168556140",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Flavonoids are phenolic substances isolated from a wide range of vascular plants, with over 8000 individual compounds known. They act in plants as antioxidants, antimicrobials, photoreceptors, visual attractors, feeding repellants, and for light screening. Many studies have suggested that flavonoids exhibit biological activities, including antiallergenic, antiviral, antiinflammatory, and vasodilating actions. However, most interest has been devoted to the antioxidant activity of flavonoids, which is due to their ability to reduce free radical formation and to scavenge free radicals. The capacity of flavonoids to act as antioxidants in vitro has been the subject of several studies in the past years, and important structure-activity relationships of the antioxidant activity have been established. The antioxidant efficacy of flavonoids in vivo is less documented, presumably because of the limited knowledge on their uptake in humans. Most ingested flavonoids are extensively degraded to various phenolic acids, some of which still possess a radical-scavenging ability. Both the absorbed flavonoids and their metabolites may display an in vivo antioxidant activity, which is evidenced experimentally by the increase of the plasma antioxidant status, the sparing effect on vitamin E of erythrocyte membranes and low-density lipoproteins, and the preservation of erythrocyte membrane polyunsaturated fatty acids. This review presents the current knowledge on structural aspects and in vitro antioxidant capacity of most common flavonoids as well as in vivo antioxidant activity and effects on endogenous antioxidants.
|
2022-12-31T18:11:31.487Z
|
73,002,535 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/archdischild.2011.300164.117",
"MAG": "2141131984",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Aim Benchmarking neonatal services alongside family representatives is a pinnacle of good practice and one that neonatal networks' performance may be measured against. Methods An audit specific to benchmark Principle 3 was developed from the Toolkit for High Quality Neonatal Services (2009) and administered to 11 neonatal service providers in a staged schedule of unit visits. Results The results offered a broad outline of the current care provision of services and the facilities being offered in all the units across the Network. The benchmark identified a number of issues requiring further address; some being minor and relatively cost neutral while other aspects required major work with large financial-resource implications. In some cases capacity and storage of equipment have taken precedence, thus infringing upon the families welfare and allowing a void of basic facility provision (paucity of sitting area and drink facility). Nevertheless across the network examples of innovation and good practice can be cited and there remain opportunities to share and pool resources. Summary By undertaking this benchmark the Yorkshire Neonatal Network has demonstrated a commitment to assessing the progress of its units and the services that are currently being offered to the families and babies. For many neonatal care provider trusts it will indeed be a challenge to demonstrate that procedures are being put into place to bring about changes to enhance the quality and safety of care-facilities being offered to their service users.
|
2022-02-11T09:28:38.185Z
|
21,039,673 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/17470218.2016.1144773",
"MAG": "2294223984",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Circumstances in which the speech input is presented in sub-optimal conditions generally lead to processing costs affecting spoken word recognition. The current study indicates that some processing demands imposed by listening to difficult speech can be mitigated by feedback from semantic knowledge. A set of lexical decision experiments examined how foreign accented speech and word duration impact access to semantic knowledge in spoken word recognition. Results indicate that when listeners process accented speech, the reliance on semantic information increases. Speech rate was not observed to influence semantic access, except in the setting in which unusually slow accented speech was presented. These findings support interactive activation models of spoken word recognition in which attention is modulated based on speech demands.
|
2022-02-12T21:32:23.840Z
|
12,843,667 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15406/JOENTR.2015.02.00009",
"MAG": "2181302886",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The frontal mucocele remains a disease difficult to treat even in the era of functional endoscopic sinus surgery (FESS). Indeed, recurrence it is a typical complication of both endoscopic endonasal and transcranial approach or as a consequence of facial fracture. The modern endoscopic endonasal approach to the frontal sinus allows the marsupialization of the pathology in all those cases in which the mucocele is reached via the route of nasal drainage and is optimal when the location of the mucocele is medial. After infection or as a result of their invasion and growth, mucoceles of the frontal sinus can give rise to intracranial and orbital complications. The most versatile and used transcranial approach is considered the Sinus Fat Obliteration (SFO). We describe the case of a 47 years old patient who under went FESS and OFSO for bilateral recurrence of mucocele within a mega-frontal-sinus. The lesion reached the left supra orbital region with erosion of the roof of the ipsilateral orbit. The endoscopic approach, in our experience, it is necessary in the forms of mucocele complicated by orbital medial and superior extension. Instead, in the presence of a mega-frontal-sinus, of a lateral extension of the mucocele as well and the clinical history of relapses of the disease is also indicated the transcranial surgical approach. The Sinus Fat Obliteration (SFO) minimizes the risk of complications with no need for a postoperative neurointensive unit stay compared to the intervention of cranialization. In fact the patient object of this work had a regular postoperative course and was discharged on the sixth day with excellent aesthetic results.
|
2022-02-13T04:05:54.811Z
|
87,106,401 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2331/SUISAN.32.847",
"MAG": "2333804985",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The tendency of the boats not to fish actively or to take recess at night and the large variation of the length of daytime during long season at high tatitudal waters suggested the possibility of the number of daily hauls depending on the length of daytime. In confirmation of this possibility, the daily reports by the 22 Danish seiners of one of the fish-meal fleets in the Bering Sea during the entire season in 1963 were analyzed here, too. And the results obtained are summarized as follows: 1. The number of daily hauls per boat showed a general tendency of increase with elongation of daytime, although fluctuated severely from boat to boat and day to day even within successive 10 days. 2. Analysis after stratification according to the area revealed the following tendencies: The number of daily hauls changed closely depending on the length of daytime during the season in which the boats operated in Area A and Area B, but this was kept at a stable level of about seven hauls a boat regardless of the length of daytime during the season in Area C. 3. The presence of a close relation of the number of daily hauls to either the depth of fishing ground or the daily catch was found in the previous reports. Reasonable attention should, therefore, be paid to the close relation of the depth of fishing ground or the daily catch to progress of the season. This made it hard to isolate the dependence of the number of daily hauls per boat on the length of daytime from that on the other factors.
|
2022-06-03T12:41:32.047Z
|
111,051,096 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.13031/2013.5814",
"MAG": "2062433730",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A flow-through electrical treatment system was evaluated as a method to eliminate S typhimurium in poultry
scalder water. The flow-through treatment system consisted of an inlet tank, a treatment cylinder, and an outlet tank. A dc
power supply provided electrical signals to platinum wire electrodes in the treatment cylinder. With 0.15 M NaCl added as
an electrolyte, a 2-A electrical current was applied to poultry scalder water flowing through the treatment cylinder at a rate
of 5 L/min. Residence time in the cylinder was 1.82 min. Samples were tested for salmonellae using standard plating
methods as well as pre-enrichment/enrichment techniques. All salmonellae were eliminated from the treated poultry scalder
water while the untreated scalder water contained large numbers of salmonellae.
|
2022-08-24T20:38:12.516Z
|
251,918,084 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24030/24092517-2022-0-3-51-60",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The article is devoted to the policy of Peter I directed at the subjugation of the church power to the secular one. As an integral system of measures it showed itself at the turn of the 17th and 18th centuries. Before that Peter’s worldview was formed I the situation of discussions of Russian Old Believers, Helenists and Catholics. The striving for the primacy of the secular power in the state was characteristic no only for Peter I, but also for the first tsars of Romanov dynasty. That idea found various realization in the Protestant and Catholic worlds. The supporters and executers of Peter’s police were found among the secular an church Russian elites. Te works and sermons of certain clerics demonstrated the transfer from the idea of the symphony of powers to proclaiming the tsar as pontifex. The rise of the secular state demonstrated itself in its claim to the church property; the introduction of the liability for military service for church-owned peasants, the establishment of monastery staff regulations and expulsion of many clerical categories from the taxless persons, the use of monasteries as material base for the formation of the social charity system. The strengthening of the secular elements in Russia demonstrated itself in the policy of religious tolerance in regard of the representatives of various Christian confessions, in the attempts to use the Christians from other countries in the interests of the state.
|
2022-08-30T15:35:22.139Z
|
27,648,546 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000328273",
"MAG": "1966203564",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.karger.com/Article/Pdf/328273"
}
|
Breast magnetic resonance imaging (MRI) is the most sensitive imaging modality for the detection of breast cancer. Its specificity is equivalent to that of mammography. Nowadays, breast MRI is an absolutely essential breast imaging method. Technical innovations allow dynamic contrast-enhanced (DCE) MRI of both breasts with high image quality. Thereby, DCE breast MRI should always be performed with regard to current standards. New quantitative techniques such as diffusion-weighted MRI are promising. However, they still have potential pitfalls, in particular with regard to the diagnosis of non-mass lesions and small breast lesions. Ongoing technical innovations can possibly help to further optimize breast MRI.
|
2022-09-13T03:41:34.941Z
|
231,617,443 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SCSE49731.2020.9313026",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Sri Lankan apparel industry is the most significant and driving contributor to the country’s economy by constituting a large portion of GDP. In the highly competitive apparel world, manufacturers search solutions for problems such as worker inadequacy while minimizing the human impact. Therefore, there is a need for apparel manufacturers to enhance value chain processes with the latest technologies. Industry 4.0 is the fourth industrial revolution that transforms the physical production into a combined cyber-physical production environment with IoT and decentralized intelligence. It enhances the process functions from new product development to logistics by providing real-time visibility of the production flow. Existing literature mentions the applications of Industry 4.0 in the apparel industry, but these have not addressed the issue of assessing the readiness for its adaptation in the apparel value chain process. Hence this scrutiny proposes a model to assess the current level of readiness of the Sri Lankan apparel industry to adapt Industry 4.0 technologies and practices. The model was developed based on a systematic review of literature with the industry experts’ guidance. The factors that determine the readiness for Industry 4.0 within an organizational context were classified under four categories; People, Process, Technology and Data which were defined as readiness dimensions. The proposed model consists of five readiness levels from 0 to 4 namely: Stranger, Beginner, Intermediate, Advanced and Elite. This model enables managers to measure the readiness for adapting of Industry 4.0 in selected apparel value chain processes by using the specified minimum requirements under each dimension and level. The outcome of this study indicates that Sri Lankan apparel industry is in “Intermediate” level in terms of overall readiness with a value of1.91 in the predefined readiness scale from 0 to 4.
|
2022-10-13T15:29:15.661Z
|
153,553,009 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1468-0408.2012.00544.x",
"MAG": "1872910393",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study addresses the emerging financial management focus of publicly and privately funded universities in the global marketplace, focusing on their financial management strategies. Despite regional and national differences, both public and private universities are found to exhibit a global trend towards operating as predominantly market funded commercial organisations. In many countries this reflects the insinuation of New Public Management philosophies into university missions and strategies. University objectives show signs of serving an underlying financial imperative often driven by constrained government funding of higher education and the expansion of private higher education institutions. Revenue expansion through mass education and engagement in the education export trade emerge as primary financial management strategies for a self-generating profit oriented business model of higher education.
|
2022-12-13T03:08:52.472Z
|
43,233,727 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/03009749609065653",
"MAG": "2163958367",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We report the case of a 61-year-old woman who presented bilateral blindness at the age of nineteen. Although she did not receive any treatment, she did not present any other symptoms through 40 years of follow-up. After reviewing the literature, we have not found any case of bilateral blindness as the first manifestation of TD without further progression of the disease despite the absence of treatment.
|
2022-12-15T00:50:21.939Z
|
1,186,018 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/ijms18102141",
"MAG": "2763088482",
"PubMedCentral": "5666823"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1422-0067/18/10/2141/pdf?version=1508143374"
}
|
The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune profile arising from the need to encapsulate the helminths while simultaneously repairing tissue damage. According to the old friend’s hypothesis, the diminished exposure to these parasites in the developed world has resulted in a dysregulated immune response that contributes to the increased incidence of immune mediated diseases such as Multiple Sclerosis (MS). Indeed, the global distribution of MS shows an inverse correlation to the prevalence of helminth infection. On this basis, the possibility of treating MS with helminth infection has been explored in animal models and phase 1 and 2 human clinical trials. However, the possibility also exists that the individual immune modulatory molecules secreted by helminth parasites may offer a more defined therapeutic strategy.
|
2022-12-18T04:23:32.469Z
|
109,701,838 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4237/GTP.V2I1.31",
"MAG": "1983906867",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A busca pela melhoria da qualidade nas empresas construtoras teve inicio com a implantacao de sistemas de gestao da qualidade nas construtoras. Recentemente tem se observado tambem o interesse por parte de alguns projetistas na organizacao dos seus sistemas de gestao tomando por base os requisitos da norma ISO 9001/2000.Os escritorios de arquitetura foram os ultimos a buscar este caminho, apesar de ser reconhecida a importância do projeto para a reducao dos desperdicios e racionalizacao da construcao. Um dos motivos que leva ao descredito por parte de alguns arquitetos em relacao aos beneficios gerados pela implantacao de um sistema de gestao da qualidade e o fato desse sistema nao garantir a qualidade do projeto em si, mas da gestao do processo de desenvolvimento do projeto. Com o objetivo de identificar os impactos provocados pela implantacao de um sistema de gestao da qualidade nos moldes da norma ISO 9001/2000, realizou-se um estudo de caso nos escritorios de arquitetura certificados. Os resultados indicam certa mudanca de postura a partir das exigencias da norma, com destaque para a maior preocupacao, por parte dos projetistas, com a gestao da informacao e comunicacao. Este artigo foi extraido da dissertacao de mestrado defendida e aprovada no PROARQ/FAU/UFRJ.
Palavras-chave: Escritorios de Arquitetura, Gestao de Empresas, Sistema de Gestao da Qualidade, Gestao da Informacao.
|
2022-12-30T00:09:37.702Z
|
135,586,109 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7234/COMPOSRES.2014.27.3.090",
"MAG": "2035796436",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT: Cure shrinkage during cure process of polymer matrix composites develope residual stress that causesome structural deformation, such as spring-in, spring-out and warpage. The carbon/epoxy prepreg used in this studyis Hexply M21EV/34%/UD268NFS/IMA-12K supplied by Hexcel corp. Cure shrinkage and degree of cure measuredby TMA(thermomechanical analyzer) and DSC(differential scanning calorimetry). Cure shrinkages are measured byTMA within a temperature range of 140~240 o C in a nitrogen atmosphere, and degree of cure determined by the heatof reaction using dynamic and isothermal DSC runs in argon atmosphere. As a result, the cure shrinkage is increaseddramatically in a degree of cure range between 27~80%. the higher the cure temperature, the lower the degree of cureoccurring to begin cure shrinkage.초록 : 복합재료의 경화 시 발생하는 수축 변형률은 복합재료 구조물 내에 잔류응력을 발생시키며 이러한 잔류응력은 spring-in, spring-out, warpage와 같은 구조물 변형의 원인이 된다. 본 연구에서는 Hexcel사의 “Hexply M21EV/34%/UD268NFS/IMA-12K” prepreg를 사용하였다. 시험편의 경화에 따른 cure shrinkage 변화를 DSC(differential scanningcalorimetry)와 TMA(thermomechanical analyzer)를 o이용하여 측정하였다. 수지의 수축률은 140~240C 구간에서 20
|
2022-01-27T12:15:52.502Z
|
96,353,154 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/LA980106W",
"MAG": "2010574643",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The surface of a p-MoSe 2 electrode has been observed in 0.05 M HNO 3 , in situ, by electrochemical scanning tunneling microscopy (ECSTM). Randomly oriented nanometer size spots have been observed on the surface. The STM images of the p-MoSe 2 surface have been found to change with the electrode potential. That is, the nanometer size spots appeared as a dark contrast under a smaller band bending condition (0.2 V versus SCE) while the spots disappeared or further appeared as bright contrast under a larger band bending condition (0 and -0.2 V versus SCE). This is presumed to result from whether the acceptor level, within the band gap of the p-MoSe 2 , is occupied or not. In addition, it will depend on the electrode potential, which determines the amount of the band bending.
|
2022-02-10T14:29:15.491Z
|
220,132,972 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/ebm.14.2.63",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose and procedure section in each issue of EvidenceBased Medicine describes the criteria for selecting articles for inclusion. The journals read are listed at http://hiru.mcmaster. ca/hiru/journalslist.asp. All articles that meet our criteria in the reviewed journals are cited in Evidence-Based Medicine, but there is not enough space to abstract them all. The following articles passed all criteria but were not abstracted. Practising clinicians rated them for clinical relevance and newsworthiness, and the mean scores are displayed. A fuller list of articles and a sample of the rating form are available on the Evidence-Based Medicine website (http://ebm.bmjjournals.com/cgi/content/full/14/2/e1).
|
2022-09-01T01:10:44.887Z
|
98,837,775 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/PREP.201300073",
"MAG": "2143421164",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A theoretical model was developed in order to predict the size of agglomerates ejected from aluminized composite solid propellants. The model accounts for aspects of both mechanistic and geometric approaches. A thin mobile surface layer is assumed to dominate particle accumulation. Agglomeration number Nag expressing the ratio between ignition and accumulation times, was found to greatly affect the characteristics of agglomeration phenomena, as noted in previous works. The concept of a characteristic distance De of the mobile surface layer was introduced, depending mostly on coarse AP particle diameter and loading. It was found to have a significant effect on the resulting agglomerate diameter. An agglomeration threshold was defined as the particle diameter equal to the mobile layer thickness. Particles smaller than this threshold have shown tendency to form large agglomerates, whereas particles with a somewhat larger diameter have demonstrated faster ignition and smaller ejected agglomerates. Model predictions for a number of propellant compositions showed good agreement with other theoretical studies as well as with experimental results.
|
2022-09-13T15:37:38.271Z
|
245,752,904 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.35870/EMT.V5I2.474",
"MAG": "3214447805",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The specific objectives of this research are; 1) To find out the development of production, working capital, labor, sales volume, wage level, selling price, material costs, and profits of brick industry business actors, 2) To determine the feasibility of brick business in Banda Aceh City, and 3) To analyze strategic flexibility in the development of the brick refinery business after the COVID-19 pandemic. Descriptive and quantitative analysis was used to analyze the data, with direct observation of a research object in order to determine the condition of the business location and the characteristics of the brick business in Banda Aceh City. In order to determine whether or not the business was feasible, the business was carried out using BCR analysis calculations. Based on the results of research and discussion, it can be concluded that the development of the brick refinery business is known. The results of data analysis regarding the amount of production, labor, working capital, sales volume, wages, selling prices, raw material costs, and business profits of the brick refinery have increased every year. In contrast, in 2020-2021 there will be a decline caused by declining demand and high raw materials for brick processing. The results of the calculation of business feasibility in terms of Capital and Revenue using the BCR formula show that the capital and revenue variables have a positive effect on the feasibility of the 2017 to 2019 Brick Refinery Business or in other words that the Brick Refinery Business does not lose. It was reversed in 2020-2021 where the brick business decreased in demand but the stock became large and no significant losses were found. However, the bricks business revenue has decreased. The brick refinery business seen from the marketing aspect experienced positive developments in 2017-2019, this can be seen from the number of requests that always increase every year. It is different in 2020-2021 where the development from the marketing aspect is low, due to the pandemic and reduced development in Banda Aceh City.
|
2022-11-25T16:53:03.840Z
|
206,656,525 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TCSII.2016.2585680",
"MAG": "2461166410",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A novel 4-D hyperchaotic four-wing system with a saddle–focus equilibrium is introduced in this brief. The qualitative analysis of the proposed system confirms its complex dynamic behavior, which is studied by using well-known numerical tools of nonlinear theory, such as the bifurcation diagram, Lyapunov exponents, Poincaré maps, and phase portraits. Furthermore, the novel hyperchaotic system is experimentally emulated by an electronic circuit, and its dynamic behavior is studied to confirm the feasibility of the theoretical model.
|
2022-12-10T15:02:16.845Z
|
8,556,961 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CDC.2010.5717242",
"MAG": "2134898073",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this work, the computational effort of Mixed Integer Quadratic Programming solvers based on branch and bound is studied. The origin of this interest is that hybrid MPC problems for Mixed Logical Dynamical systems can be formulated as optimization problems in this form and since these have to be solved in real-time, it is interesting to be able to compute a good bound on the computational complexity. Classically, the bound on the worst case computational complexity is given by the case when it is necessary to expand all nodes in the entire tree. The usefulness of branch and bound relies on the fact that this worst case scenario is very rare in practice. The objective in this work is to reduce the gap between the conservative worst case bound on the number of nodes and the number of nodes actually necessary to explore on-line in the optimization routine. Approaches to compute this bound are presented and motivated theoretically and the performance of the analysis is evaluated in numerical examples.
|
2022-12-16T11:00:02.926Z
|
241,544,765 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/med/9780198827191.003.0012",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This chapter in the Oxford Handbook of Clinical Specialties explores the specialty of psychiatry. It discusses seeing patients, taking a psychiatric history, the mental state exam, risk assessment, confidentiality, physical examination, descriptive psychopathology, the classification of disorders (ICD-10/DSM-5), and community care. It explores schizophrenia, depression, bipolar affective disorder, anxiety, withdrawing psychotropics, suicide, self-harm, crisis intervention, urgent psychiatry situations, and managing violence. It describes dealing with delirium, dementia, depression, psychosis, and behavioural difficulties, as well as disorders of sleep, autism spectrum disorders, attention deficit hyperactivity disorder, intellectual disability, and personality, eating, psychosexual, and perinatal disorders. It examines therapies and psychotherapies including cognitive, behavioural, dynamic, systemic/family, counselling, and supportive, group, play, and art therapies. It discusses compulsory treatment and hospitalization, the Mental Health Act law and consent, and capacity.
|
2022-01-23T04:23:14.336Z
|
214,569,114 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1107/s010876731909888x",
"MAG": "2997632320",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://journals.iucr.org/a/issues/2019/a1/00/a57911/a57911.pdf"
}
|
Organic nonlinear optical materials are used for a wide range of applications, including terahertz (THz) and second harmonic generation. Optimal molecular arrangements in the crystal structure are judged by θp, which refers to the angle between the main transfer axis and the crystallographic axis. θp ranges from 0° for perfectly aligned noncentrosymmetric packing to 90° for centrosymmetric arrangement. Because noncentrosymmetric packing is essential to obtain a second-order material response, several strategies have been designed to overcome the anti-parallel arrangements often favored by dipole-dipole interactions. One of the most common approaches involves inducing hydrogen-bonding networks between chromophores. However, hydroxyl groups decrease the molecular hyperpolarizability compared to N-alkyl and O-alkyl groups, such as -OMe or -N(Me2). A different method takes advantage of the ability of organic salts to pair the same THz-generating cation with different anions introducing different interactions and thereby changing the molecular packing from centrosymmetric to noncentrosymmetric. Here, we introduce an additional means of controlling crystal structure: cation modification. By switching a methyl (1-carbon) for an ethyl (2-carbon) group in the quaternary nitrogen moiety of the cation, we observe dramatic changes in θp from 90° to 0° without significantly impacting hyperpolarizability. We attribute this packing behavior to the increased steric effect of the ethyl group that results in larger intermolecular distances and so enables a parallel, noncentrosymmetric arrangement of chromophores in the crystalline state. This engineering strategy will deeply impact the way crystals for nonlinear optical applications are designed.
|
2022-01-27T11:12:31.524Z
|
59,029,436 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2991/ITMS-15.2015.447",
"MAG": "2318181528",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Character design vocational education institutions are not mature yet. Existence positioning is unclear, curriculum loose, educational model rigidities. In education reform, the design should be between globalization and local educational cultural to find points of integration, in order to cultivate the students' professional point to explore the characteristics of vocational education in line with the new model, closely integrated with social practice. KEYWORD: Vocational education; Character design; Educational reform; Exploration International Conference on Industrial Technology and Management Science (ITMS 2015) © 2015. The authors Published by Atlantis Press 1831 have a more complete set of professional subjects, but in terms of the integrity and effectiveness of the education system, there are still many shortcomings. Bridging between the various programs is not strong; the relationship will not allow students to learn the process of linking various courses. In addition, integration between design theory and practical operation of the task does not close, practical course content practicality is not strong; the knowledge cannot be used, so many students to complete their studies after a lack of confidence in the face of actual work, and feel helpless. Third, the educational model problem. In vocational education mode, the practical part is often more than 50%. While many colleges also follow the character design education theory and practice of both this mode of education, but will always be regarded as two separate modules to each other, and the lack of valuable social practice, the advantages of higher vocational education cannot be play. 2.2 Enlightenment of Foreign Art and Design education model Foreign art design education model and vocational education in China is similar to laboratory-based, thematic design projects as the main refining the theory in practice, the formation of a separate education system. American Cranbrook Academy of Art: school-enterprise cooperation, production research integration. After the Nazis closed the Bauhaus School of design talent to move to the United States, the United States became the center of design education. Cranbrook Academy of Design developed the Bauhaus modern design ideas, home design and furniture company specialized long-term cooperation to create a "school-enterprise cooperation, combining production" model. It selection from students outstanding design talents to open "studio" as the main teaching mode, the formation of industry, academia, research integration model, founded the American elite design education brand. University of Wolverhampton, UK: combining traditional and modern factory-style education model. University of Wolverhampton in the English arts and crafts tradition and modern design combined, mainly reflected in the glass and ceramic design education mode. It has a range of technology processing lines and plants, work needs kiln, polishing, glazing, casting and other equipment readily available, as a complete plant. British glass design products are the world's largest consumer of luxury, nature and the University of Wolverhampton training a large number of professionals are closely related. University of Art and Design in Helsinki, Finland: Professor studio + factory-style teaching. College equipment, just as a separate facility, each student has a separate table in the studio by a professor of theory and practice guidance, and then put the factory floor exercise professional competence. Manufacturing production and social work from design to post almost unanimously, cultivate top talents to work and study. As can be seen from the educational model class foreign School of Design, between theory and practice, the boundaries between school education and practical work is very vague, theoretical constantly be updated on the basis of technological innovation. Vocational education through the exploration and hone technique to accumulate experiences and achievements naturally formed precise positioning and professional education brand with professional features, so that design education has a unique value. With our emphasis on vocational education, the state training equipment, laboratory construction put a lot of money, a lot of vocational colleges have the best equipment repairing strength, and character design education is also one of the beneficiaries. However, how to define the character design of the meaning and purpose of education, have full use of favorable conditions to develop students' professional equipment quality, which is the fundamental problem facing the education reform. Character design of vocational education should not blindly copy foreign models, but should local educational resources, education, culture, industry needs, formed to train qualified professional personnel to point to the practice of modern education model. 3 CHARACTER DESIGN POINT OF EDUCATION REFORM: THE OVERALL QUALITY OF STUDENTS 3.1 Scientific work: to develop work habits According to the specific circumstances of the task of research, setting up a series of workflows, designing the characters will become an important education reform work. In practical work, or project implementation, will have to follow certain work processes, work well underway. Theory and Practice of relatively independent undergraduate education model obviously does not apply to the task-oriented vocational education basic features. Standardized work processes from design to allow students a clear relationship between the various stages of production, and thus fully understand the objectives and requirements of each stage of the work required to effectively perform the tasks at work. In times of difficulties, but also can find links difficulty, to find an appropriate solution. Establish a scientific work can not only help students adapt to the working methods of the future, but also to cultivate their methodical work habits.
|
2022-02-11T16:56:02.055Z
|
191,464,864 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3917/RIS.068.0011",
"MAG": "2085868554",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
L'interet du public pour les questions internationales ainsi que la tendance a tenir compte de l'opinion dans la conduite des relations exterieures ont renforce la place accordee aux problemes internationaux dans les medias, et ont suscite un recours aux experts pour eclairer les evenements. Cette evolution est positive. Car, si pour certains la rigueur scientifique interdirait de vulgariser en un temps limite un savoir complexe, on peut estimer que la pedagogie passe aussi par les medias. Neanmoins on constate des effets negatifs : le risque de verser dans des analyses simplistes, la tentation de faire appel a l'expert disponible plutot qu'a l'expert competent. Mais le reproche le plus important est celui de la desinformation operee par certains experts. Il est ainsi du devoir des medias d'exercer une vigilance a cet egard.
|
2022-09-05T09:07:02.501Z
|
110,500,587 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/prs.11498",
"MAG": "2114534898",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Prework in preparation for process hazard analysis (PHA) is vital for an efficient study. Precompletion of PHA worksheets in an effort to reduce the time needed for a PHA study may detract from the quality of the study and also may not be acceptable to regulators. Appropriate prework is described, and proposals are made for when worksheets can be precompleted. © 2012 American Institute of Chemical Engineers Process Saf Prog, 2012
|
2022-09-09T11:50:25.395Z
|
39,737,954 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/JNR.490080215",
"MAG": "2037851900",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We have previously demonstrated that both peripheral and central neurons from 8 day embryonic chick and newborn mouse can be maintained in a serum‐free medium using the N1 supplement consisting of insulin, transferrin, putrescine, progesterone, and selenite. In the present studies we show that dorsal root ganglionic (DRG) neurons from embryonic chick (E7–E15) and neonatal mouse can be cultured in a serum‐free environment with only the addition of insulin and transferrin, plus Nerve Growth Factor (NGF). Chick DRG from E10–E15 contain a population of neurons sensitive to a chick embryo eye‐derived ganglionic neuronotrophic factor (GNTF), which is distinct from the neuronal subset dependent upon NGF. The GNTF‐dependent chick neurons can also be maintained in culture with insulin and transferrin supplements. Neonatal mouse DRG neurons, whether supported by NGF or eye‐derived GNTF, likewise survive in serum‐free medium with only insulin and transferrin. Limited numbers of neurons survive for the first 24 hours in a serum‐free medium lacking insulin or transferrin, but failed to display neurite outgrowth even in the presence of added trophic factor.
|
2022-09-12T06:02:31.674Z
|
104,060,488 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/C7NJ03877A",
"MAG": "2783254627",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Due to the extensive existence of manganese (Mn) in natural aquatic environments and the increasing applications of graphene oxide (GO) products, the co-existence of Mn and GO in natural waters would be inevitable. However, the effect of their interactions on the transportation and fate of GO is not clear. In this work, the impact of different species of manganese on the aggregation of GO was investigated systematically through batch experiments under different chemical conditions (e.g., Mn concentration and pH). The results indicated that the concentration of Mn(II) played a significant role in the aggregation and deposition of GO. The critical coagulation concentration (CCC) of Mn(II) for the aggregation of GO suspension (within the range of 5–100 mg L−1) was about 3.0 mM at neutral pH conditions. At high pH values (8–10), only 0.3 mM Mn could destabilize the GO suspension due to the in situ freshly formed oxidized manganese species through mechanisms of electrostatic-adsorption, neutralization, and catching–sweeping interactions. However, addition of pre-prepared MnO2 had little effect on aggregating the GO suspension over a wide range of pH value. Overall, these findings are useful for understanding and predicting the fate and transport of GO in both aquatic environments and wastewater treatment areas in the presence of manganese.
|
2022-09-15T04:51:38.878Z
|
145,139,403 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1086/220584",
"MAG": "2079056939",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
From a sociological viewpoint two phenomena have to be distinguished: the community of religiosi and the religious order properly speaking. The former corresponds to the psychological group and the familistic or Gemeinschaft type, while the latter represents an organized group of the Gesellschaft type. The principal historical types are analyzed to show the stages from the pure community of religiosi to the fully developed order: monasticism, as a total way of life; the canons regular and military orders combining life"in religion" whit the status of priests or knights "in the world"; the friars, who tend toward a purposive organization in the service of the church; and, finally, the Jesuit order, the mature product of a long evolution, with its professional devotion to the objective institute, rationality, individualization, and depersonalization of intragroup relations.
|
2022-09-27T15:27:57.443Z
|
13,251,374 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ECRTS.2007.83",
"MAG": "2112583376",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This work investigates the problem of scheduling network resources in the context of a cooperative mobile multi-robot system that exchanges messages with firm real-time constraints using a wireless network compliant with the recently created IEEE 802.11e amendment. Given the physical characteristics of wireless communication, message retransmission becomes a crucial issue, especially in a realtime application. Experiments performed in the context of this work show that the regular approach for retransmission proposed in the IEEE 802.11e is not suitable for real-time applications that require a certain level of reliability. To tackle this problem, the current work proposes a new mechanism called Integrated Scheduling and Retransmission Approach (ISRA) that integrates messages scheduling and retransmission in a unified manner at the MAC layer. Our proposal is able to deal with residual transmission errors and thereby increases the reliability level of the real-time messages. Our approach is evaluated through simulations for different scenarios of traffic load and compared with the standard approach of the 802.11e for scheduling and retransmission of real-time messages. Obtained results show that ISRA presents a high adaptability and does not get affected by variations in the network load or topology.
|
2022-12-16T08:54:14.251Z
|
756,119 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000355190",
"MAG": "1971084012",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cytokine-induced killer (CIK) cells are heterogeneous effector T cells with diverse T-cell receptor specificities with non-major histocompatibility complex-restricted cytolytic activities against tumor cells and are considered a promising therapeutic approach against hematologic malignancy. Recently, it has been reported that IL-15-activated CIK cells are superior to cells generated according to the standard protocol; however, the underlying mechanism remains to be elucidated. In the present study, we found that in IL-15-stimulated CIK cells, Toll-like receptor 4 (TLR4) expression was upregulated. Upon knockdown of TLR4, the cytolytic activity was considerably compromised. Re-expression of TLR4 in CIK cells restored their function, confirming the essential role of TLR4 in CIK cell cytotoxicity. Collectively, our study demonstrated that TLR4 was essential for the cytotoxicity of CIK cells against tumor cells, which might provide a novel approach to promote the therapeutic efficacy of CIK cells against hematologic malignancy.
|
2022-12-19T09:29:04.857Z
|
34,727,604 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/JLT.2017.2726518",
"MAG": "2735413099",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Spatial transients of the modal power distribution are reported for a varied configuration of air holes in the inner cladding of multimode solid-core photonic crystal fibers. Such inner cladding forms an intermediate fiber layer seen in W-type fibers with the layer's own effective refractive index due to the distinct size and/or spacing of air holes in it. We show how the modal distribution transients along the fiber depend on the number of rings in the inner cladding containing the distinct arrangement of air holes, and on the size and spacing of such holes in addition to the type of launch condition (excitation).
|
2022-12-21T19:13:17.632Z
|
31,293,778 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/S1984-82502014000400004",
"MAG": "2016442646",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Carboplatin is a derivative of cisplatin; it has a similar mechanism of action, but differs in terms of structure and toxicity. It was approved by the FDA in the 1980s and since then it has been widely used in the treatment of several tumor types. This agent is characterized by its ability to generate lesions in DNA through the formation of adducts with platinum, thereby inhibiting replication and transcription and leading to cell death. However, its use can lead to serious inconvenience arising from the development of resistance that some patients acquire during treatment, limiting the scope of its full potential. Currently, the biochemical mechanisms related to resistance are not precisely known. Therefore, knowledge of pathways associated with resistance caused by carboplatin exposure may provide valuable clues for more efficient rational drug design in platinum-based therapy and the development of new therapeutic strategies. In this narrative review, we discuss some of the known mechanisms of resistance to platinum-based drugs, especially carboplatin.
|
2022-12-29T06:08:06.558Z
|
222,417,155 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IMS30576.2020.9224073",
"MAG": "3093664731",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Use of advanced signal processing techniques has a potential of pushing the envelope in improving the performance metrics of RF circuits. In this work, digitally-assisted, dual-path Doherty architecture is used to improve the efficiency of high power GaN PA designed for infrastructure applications. Optimized phase delay adjustment between Carrier and Peaking PA paths, and improved gain profile of Peaking PA path (achieving dynamic power splitting) yields higher efficiency of operation with tradeoff of degraded linearity. Segmented-Digital predistortion approach is used which improves the linearization while keeping the model complexity low. For hardware validation, NXP's 300W asymmetric GaN Doherty PA operating across 2535–2635 MHz band is used. Using dual-path GaN Doherty PA operating at 2.55GHz, for single LTE20 carrier 65% efficiency is achieved at the average output power of 47.5dBm with linearity better than -56dBc, which is an efficiency improvement of 3–5 percent points across the band (2535–2635 MHz) when compared with conventional single-path GaN Doherty PA. In addition, linearity performance of waveforms with instantaneous bandwidth of 60 MHz and 100 MHz is provided (Drain Efficiency=63.4/62.3 %; Linearity=-53/-48 dBc respectively).
|
2022-01-27T10:35:49.402Z
|
123,643,492 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.163139",
"MAG": "2105274033",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A method for isolating three-dimensional features of known height in the presence of noisy data is presented. The approach is founded on observing the locations of a single light stripe in the image planes of two spatially separated cameras. Knowledge relating to the heights of sought features is used to define regions of interest in each image, which are searched to isolate the light stripe. This approach is advantageous because spurious features that may result from random reflections or refractions in the region of interest of one image usually do not appear in the corresponding region of interest of the other image. It is shown that such a system is capable of robustly locating features such as very thin vertical dividers even in the presence of spurious or noisy image data that would normally cause conventional single-camera light-striping systems to fail. The discussion that follows summarizes the advantages of the methodology in relation to conventional passive stereoscopic systems as well as light-striped triangulation systems. Results that characterize the approach in noisy images are also provided.
|
2022-12-09T13:17:46.046Z
|
219,454,982 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1757-899X/826/1/012008",
"MAG": "3026367389",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The most damaged elements of oil field pipelines are welded joints, the life of which often does not exceed one or two years. The problem of anticorrosive protection of internal surfaces of welded pipe joints has not been solved to date. In this paper, the possibility of applying powder protective stainless coatings to the inner edges of the pipe adjacent to the annular weld is considered. The research of corrosion resistance and mechanical properties of pipe welded joints is presented.
|
2022-12-09T23:16:21.749Z
|
125,195,255 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1361-6544/aaaa09",
"MAG": "2793339672",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We study the stability in a partial linearisation framework of a particular travelling wave (0,V~) of the quasilinear Benney system, where V~ is a standing wave with a shock profile for the viscous conservation law.
|
2022-12-15T03:33:15.556Z
|
108,426,022 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.1424243",
"MAG": "1671835908",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A swept frequency reflectometry technique is being investigated as a means of determining the location of arcs in RF transmission lines. The method is applicable to both vacuum and pressurized transmission lines. Arcs are produced in a 6.3 m long resonant coaxial test line with an outer conductor diameter of 15 cm and Z0=26 Ω by injecting RF at a power level of 25–80 kW and f∼47 MHz. A septate coaxial coupler with a cutoff frequency of ∼450 MHz injects a diagnostic wave swept over a portion of the range 475–550 MHz at a sweep frequency up to 200 kHz. During the sweep period, the arc impedance can be nearly constant. The rate of phase change of the reflection coefficient of the diagnostic wave as a function of frequency is measured and used to determine the distance to the arc.A swept frequency reflectometry technique is being investigated as a means of determining the location of arcs in RF transmission lines. The method is applicable to both vacuum and pressurized transmission lines. Arcs are produced in a 6.3 m long resonant coaxial test line with an outer conductor diameter of 15 cm and Z0=26 Ω by injecting RF at a power level of 25–80 kW and f∼47 MHz. A septate coaxial coupler with a cutoff frequency of ∼450 MHz injects a diagnostic wave swept over a portion of the range 475–550 MHz at a sweep frequency up to 200 kHz. During the sweep period, the arc impedance can be nearly constant. The rate of phase change of the reflection coefficient of the diagnostic wave as a function of frequency is measured and used to determine the distance to the arc.
|
2022-01-27T06:37:00.988Z
|
193,304,939 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33588/RN.60S01.2014562",
"MAG": "2283506800",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ministerio de Economia y Competitividad de Espana (EDU2012-37452) y Universitat Jaume I (beca predoctoral 2I005-PREDOC/2013/34).
|
2022-07-31T10:17:32.731Z
|
56,694,307 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1056/NEJM197607082950208",
"MAG": "2021015104",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Presentation of Case A nine-year-old girl was admitted to the hospital because of congenital heart disease. She was born of the fifth pregnancy of a mother aged 33 years. At two months of gestation...
|
2022-08-24T23:43:24.558Z
|
93,913,556 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/POL.1983.180210907",
"MAG": "1973413491",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Methylene and phenyl C1 carbon signals of polystyrene are assigned on the basis of the signal assignments of styrene oligomers. Polystyrenes prepared with benzoyl peroxide, n-butyllithium, and trifluoroboron etherate catalysts have random distributions with probabilities of racemic dyads of 0.54, 0.56, and 0.45, respectively.
|
2022-09-23T23:01:47.069Z
|
12,506,946 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/(SICI)1097-0282(19981005)46:4<225::AID-BIP4>3.0.CO;2-R",
"MAG": "1990802145",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
At the secretory stage of tooth enamel formation the majority of the organic matrix is composed of amelogenin proteins that are believed to provide the scaffolding for the initial carbonated hydroxyapatite crystals to grow. The primary objective of this study was to investigate the interaction between amelogenins and growing apatite crystals. Two in vitro strategies were used: first, we examined the influence of amelogenins as compared to two other macromolecules, on the kinetics of seeded growth of apatite crystals; second, using transmission electron micrographs of the crystal powders, based on a particle size distribution study, we evaluated the effect of the macromolecules on the aggregation of growing apatite crystals. Two recombinant amelogenins (rM179, rM166), the synthetic leucine-rich amelogenin polypeptide (LRAP), poly(L-proline), and phosvitin were used. It was shown that the rM179 amelogenin had some inhibitory effect on the kinetics of calcium hydroxyapatite seeded growth. The inhibitory effect, however, was not as destructive as that of other macromolecules tested. The degree of inhibition of the macromolecules was in the order of phosvitin > LRAP > poly(L-proline) > rM179 > rM166. Analysis of particle size distribution of apatite crystal aggregates indicated that the full-length amelogenin protein (rM179) caused aggregation of the growing apatite crystals more effectively than other macromolecules. We propose that during the formation of hydroxyapatite crystal clusters, the growing apatite crystals adhere to each other through the molecular self-association of interacting amelogenin molecules. The biological implications of this adherence effect with respect to enamel biomineralization are discussed.
|
2022-12-16T01:36:04.567Z
|
14,962,511 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/GAAS.2002.1049040",
"MAG": "1486537404",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The FDTD and the Haar-based MRTD algorithms are applied to the full-wave modeling of highly integrated 3D microwave and millimeter wave radio front-ends that require the optimization of various components as well as the minimization of the crosstalk between them. The numerical results have demonstrated a very good computational efficiency in the calculation of the scattering parameters, the Q-factor, as well as in the estimation of the radiation pattern, of the packaging effects and of the parasitic crosstalk between neighboring geometries.
|
2022-12-16T13:16:15.672Z
|
62,725,112 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ECJA.4410770707",
"MAG": "2036350121",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Onboard resource sharing (ORS) is a method wherein, for increasing effective isotropically radiated power, surplus satellite resources (radiated power or time slots in TDMA) are used to maintain communications quality in areas affected by rain attenuation. This paper analyzes simultaneous occurrence rates of rain over a wide area using Automated Meteorological Data Acquisition System (AMeDAS) data (1 hr rain rate data at approximately 1300 locations in Japan provided by the Japan Meteorological Agency).
An ORS system is proposed using AMeDAS data as dynamic information for controlling satellite transmission power. Then a control simulation is performed by using actual reception intensities of satellite signals and rain rate information derived from AMeDAS data at corresponding times. The effect of the proposed ORS system is demonstrated in compensating for rain attenuation.
From these results it was confirmed that the forementioned compensation provides a saving of about one-third compared to the case where unavailable time is not compensated.
|
2022-12-21T09:31:58.379Z
|
26,567,172 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/49.709455",
"MAG": "2130535359",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Magic WAND project (Wireless ATM Network Demonstrator) is one of the largest projects within the European Union ACTS (Advanced Communications Technologies and Services) initiative. The project aims to design, verify, implement, and demonstrate a wireless access network for ATM LAN's. The complete range of functionality, from physical data transmission to shared multimedia application, is addressed. The WAND system is designed for indoor environments with user mobility limited to walking speed. The system's functional specification has been designed and verified using SDL (specification and description language). In this paper, the WAND system functional model is given and SDL simulation results are presented, to illustrate how the protocols support some of the key operations of a wireless access network. These include initial registration, call setup, and handover.
|
2022-12-21T15:03:09.948Z
|
142,614,031 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26877/AKS.V4I2/SEPTEMBE.546",
"MAG": "1545923051",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Penelitian ini bertujua n untuk mengetahui Efektivitas Pembelajaran Matematika Berbasis Humanistik dengan Pendekatan Konstruktivisme Berbantuan CD Interaktif Materi Segi Empat Kelas VII terhadap prestasi belajar peserta didik. Jenis penelitian yang digunakan adalah penelitian Quasy Experimental. Populasi penelitian ini adalah peserta didik kelas VII SMP Negeri 1 Jakenan yang terdiri dari tujuh kelas paralel dengan satu kelas sebagai kelas unggulan dan enam kelas yang lain mempunyai kemampuan yang bisa diasumsikan setara. Dengan teknik s a mple ramdom sampling dipilih dua kelas, kelas VIID sebagai kelas eksperimen dan kelas VIIG sebagai kelas kontrol. Variabel penelitian meliputi aktivitas intelektual (X 1 ) dan motivasi (X 2 ) sebagai variabel bebas dan prestasi belajar (Y) sebagai variabel terikat. Cara pengambilan data dengan observasi dan tes prestasi belajar. Olah data dengan uji banding t dan uji pengaruh regresi. Hasil penelitian menunjukkan bahwa pembelajaran dikatakan efektif yang ditandai oleh: a) nilai rata-rata prestasi belajar kelas eksperimen adalah 8 1 , 28 yang melebihi batas KKM 7 0; b) pengaruh aktivitas dan motivasi diperoleh persamaan artinya setiap aktivitas intelektual (x 1 ) dan motivasi (x 2 ) meningkat satu satuan maka prestasi belajar (Y) meningkat sebesar 1, 844 . Besarnya pengaruh dapat dilihat dari nilai R square = 0,872 yang berarti 87,2% prestasi belajar peserta didik dipengaruhi secara bersama-sama oleh faktor aktivitas intelektual dan motivasi peserta didik.; dan c) rata-rata prestasi belajar kelas eksprimen sebesar 81,3 sedangkan pada kelas kontrol hanya 68,4, maka kelas eksperimen memiliki rataan nilai akhir lebih baik secara signifikan daripada rataan kelas kontrol. Kata Kunci: Humanistik, Konstruktivisme ,?e?a CD Interaktif, Efektif
|
2022-02-09T07:56:19.953Z
|
106,997,898 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1680/cfec.31784.0061",
"MAG": "583788922",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In early 1996, the Singapore Government announced its decision to expand the country's mass rapid transit (MRT) system by building the North-East Line from the World Trade Centre in the south of the island to the new towns of Hougang, Sengkang and Punggol in the north-eastern part of Singapore. The 2.55bn North-East Line is approximately 20 km long and is built primarily underground using precast tunnel-lining segments. Contract C708 of this project included a stretch of bored tunnel passing through bacterially active marine clays and underneath the Singapore River, possibly the worst soil and groundwater conditions to be found in Singapore. The specification requirements for the project referred to a 100-year design life and included the use of high-performance concrete with a maximum water-cementitious material ratio of 0.45 and a minimum 28-day compressive strength of 60 MPa for the concrete used in the precast tunnel segments. In addition, the specification included the use of high yield bars with a fused epoxy coating to mitigate corrosion of the reinforcing steel due to chlorides in the groundwater. At the request of the contractor, the specifying agency accepted the use of a dense silica-fume concrete and integral waterproofing corrosion inhibitor as an alternative to the epoxy-coated bar. Over 8,000 precast, high-performance concrete tunnel-lining segments were produced for the construction of the underground tunnels, which were completed in December 2000. This paper summarises the development of the high-performance concrete mixes for the tunnel lining segments, production issues and QA/QC measures that were implemented to ensure compliance with the specification. For the covering abstract see ITRD E116313.
|
2022-02-10T08:08:21.750Z
|
70,540,513 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1300/J491v03n01_10",
"MAG": "1540563399",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The "Boomer" generation will begin to turn age 65 in 2011. This huge cohort represents both strength and a challenge to secular and religious institutions alike. A tip of the "Boomer" iceberg will be affluent. Many will be self-supporting. But a large number will be in need. A majority of the boomers are entering their prime earning years on a schedule that is actually behind that of their parents. Churches and denominations have 30 years to prepare to meet the needs of the Boomers as they enter old age.
|
2022-02-11T11:31:03.235Z
|
235,853,380 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5281/ZENODO.4477651",
"MAG": "3157623795",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
تهدف الدراسة الى ابراز ضرورة تطبيق مفهوم حوكمة المؤسسات في البيئة الاقتصادية الجزائرية والاستفادة منها في تطوير الممارسات المحاسبية بما في ذلك الإفصاح المحاسبي، وبالتالي الوصول إلى جودة التقارير المالية التي ستؤثر إيجابا على قرارات المستثمرين، والمحافظة على استمرارية نجاح هذه الشركات وسمعتها الاقتصادية.
وتوصلت الدراسة إلى أن لحوكمة المؤسسات أثر إيجابي في تفعيل الإفصاح المحاسبي وضمان جودة التقارير المالية، وهذا من خلال معامل الانحدار بلغ0.830 ومعامل التحديد المقدر بـ 63.4% في المؤسسات عينة الدراسة (اليانس، صيدال، بيو فارم).
|
2022-06-18T02:48:42.977Z
|
250,921,877 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0957-0233/13/5/309",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We describe a solar-blind UV imaging photon detector with an extended dynamic range which can be used to record very faint UV sources. This detector includes an RbCsTe photocathode, microchannel plates (MCPs) and a two-dimensional resistive anode. It is coupled with an objective lens and a UV filter which rejects daylight with an optical density higher than 12 for experiments performed outdoors at sea level. In order to increase the relatively small dynamic range of the detector due to local saturation in the MCP, a method based on control of the proximity voltage between the photocathode and the MCP has been developed. Control is performed remotely by a TTL signal. It regulates the detected event rate within a pre-defined interval. The system spatial and temporal performance has been studied in detail. A comparison between the results obtained with and without gating has been made and confirms the interest of our new acquisition system for measuring radiometric quantities of low light level sources over an extended dynamic range.
|
2022-07-30T22:06:58.145Z
|
98,161,155 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/POLA.27088",
"MAG": "2155970998",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A new aromatic host polymer poly{[1,4-bis(9-decylcarbazole-3-yl)-2,3,5,6-tetrafluorobenzene-3,3-diyl]-alt-[N-methylisatin-2-one-3,3-diyl]} (PICzFB) containing carbazole-tetrafluorinebeneze-carbazole moiety in the -conjugated interrupted polymer backbone was synthesized by superacid-catalyzed metal-free polyhydroxyalkylation. The resulted copolymer PICzFB showed a comparatively wide band gap up to 3.32 eV and high triplet energy (E-T) of 2.73 eV due to confined conjugation by the C bond interrupted polymer backbone. Blue and green light-emitting devices with PICzFB as host, FIrpic and Ir(mppy)(3) as phosphorescent dopants showed the maximum luminous efficiencies of 5.0 and 27.6 cd/A, respectively. The results suggested that the strategy of incorporating bipolar unit into the -conjugated interrupted polymer backbone can be a promising approach to obtain host polymer with high triplet level for solution-processed blue and green phosphorescent polymer light-emitting diodes. (c) 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 1037-1046
|
2022-09-23T19:52:31.611Z
|
22,899,935 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2146/ajhp130129",
"MAG": "2915487216",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
PURPOSE
The most important articles pertaining to infectious diseases (ID) pharmacotherapy published in 2012, as nominated and ranked by panels of pharmacists and physicians with ID expertise, are summarized.
SUMMARY
Members of the Houston Infectious Diseases Network were asked to nominate articles on ID research published in prominent peer-reviewed journals during the period January 1-December 31, 2012, with a major impact in the field of ID pharmacotherapy. A list of 42 nominated articles on general ID-related topics and 8 articles pertaining to human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS) was compiled. In a survey conducted in January 2013, members of the Society of Infectious Diseases Pharmacists (SIDP) were asked to select from the list 10 general ID articles and 1 HIV/AIDS-related article that they considered to be the most important. Of the 180 SIDP members surveyed, 100 (55%) and 44 (24%) participated in ranking the general ID and HIV/AIDS-related articles, respectively. Summaries of the highest-ranked articles in both categories are presented here.
CONCLUSION
With the volume of published ID-related research growing each year, both ID specialists and nonspecialists are challenged to stay current with the literature. Key ID-related publications in 2012 included updated recommendations on management of diabetic foot infections, articles on promising approaches to prevention and early treatment of HIV disease, and reports on developments in research on pharmacotherapies for methicillin-resistant Staphylococcus aureus bacteremia and Klebsiella pneumoniae infections.
|
2022-09-21T15:47:41.642Z
|
44,145,790 |
{
"externalids": {
"ACL": "S18-2008",
"ArXiv": null,
"DOI": "10.18653/v1/S18-2008",
"MAG": "2805463234",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Across disciplines, researchers are eager to gain insight into empirical features of abstract vs. concrete concepts. In this work, we provide a detailed characterisation of the distributional nature of abstract and concrete words across 16,620 English nouns, verbs and adjectives. Specifically, we investigate the following questions: (1) What is the distribution of concreteness in the contexts of concrete and abstract target words? (2) What are the differences between concrete and abstract words in terms of contextual semantic diversity? (3) How does the entropy of concrete and abstract word contexts differ? Overall, our studies show consistent differences in the distributional representation of concrete and abstract words, thus challenging existing theories of cognition and providing a more fine-grained description of their nature.
|
2022-11-26T14:16:37.430Z
|
6,516,471 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/icb/42.5.1032",
"MAG": "2175184513",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/icb/article-pdf/42/5/1032/1877929/i1540-7063-042-05-1032.pdf"
}
|
Abstract The shape and motion of the pectoral fins vary considerably among fishes that swim in the labriform mode. Pectoral fin motion in fishes is highly variable, but one conspicuous axis of this variation is the rowing-flapping axis. At one extreme of this axis, paddle-shaped fins row back and forth in a plane that is parallel to fish motion, while at the other extreme, wing-shaped fins flap up and down in a plane that is perpendicular to fish motion. We have used two fish, the threespine stickleback (Gasterosteus aculeatus) and the bird wrasse (Gomphosus varius), that fall near the extremes of the rowing-flapping axis to study the dynamic, energetic, and ecological and evolutionary consequences of this kinematic variation. Our work confirms some traditionally held assumptions about rowing and flapping dynamics and energetics but reject others. A computer simulation experiment of virtual rowing and flapping appendages makes several predictions about differences in maneuvering performance and swimming energetics between rowing and flapping, which, in turn, make predictions about the behavior and ecological distribution of fishes that vary along the rowing-flapping axis. Both laboratory and field studies of labrid swimming ability and distribution support these predictions.
|
2022-12-17T08:54:30.059Z
|
149,411,489 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25044/25392190.808",
"MAG": "2725490350",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.25044/25392190.808"
}
|
This article presents the accomplished work for the development of an idea management system to be available to higher education institutions. In surveys conducted were not found tools to attend this demand. The institution surveyed are generic to attend companies whose the focus is not education institutions with their specificities. It is presented a theoretical framework that embraces the issue management of ideas and three of the analysed tools that are available on the market to attend the demand of the institutions. Following, the information about the analysis and tool development will be presented; it has been developed by computer professionals, administrations and pedagogy.
|
2022-12-16T14:37:11.984Z
|
83,324,150 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5424/554",
"MAG": "1579985009",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
En el presente trabajo se analiza el comportamiento de 52 procedencias de Pino negral (44 procedencias nacionales y 8 extranjeras) situadas en cinco localidades del centro de Espana. El diseno empleado es el Aleatorizado en Bloques Completos con cuatro repeticiones. Los caracteres medidos a los 18 anos de la plantacion son la supervivencia, altura total, diametro normal y frecuencia de anos en que se presentan dos ciclos de crecimiento. El analisis realizado permite comcluir que las heredabilidades obtenidas para los caracteres analizados son superiores a 0,5. El factor localidad tiene una menor importancia en la expresion del policiclismo y la supervivencia que en la altura, el diametro y el volumen. La importancia del componente debido a la interaccion procedencia x localidad apunta la existencia de comportamientos diferenciales entre las procedencias. El Pino negral manifiesta una notable variacion genetica entre sus poblaciones en los caracteres analizados. Las procedencias atlanticas tienen un mayor crecimiento en altura y diametro con una tendencia baja al policiclismo, pero parecen estar peor adaptadas a las localidades que presentan un periodo seco prolongado. Las procedencias de media montana (como AV1, SO1 y CU), presentan unos resultados aceptables en el conjunto de las localidades. Es de destacar el crecimiento de las procedencias CR1 y GR2, obtenidas de repoblaciones. Algunas fuentes de semilla ampliamente utilizadas en repoblaciones (Coca, Montes del Teleno), manifiestan un crecimiento por debajo del promedio de todas las poblaciones estudiadas.
|
2022-12-18T08:42:45.993Z
|
225,305,132 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2319/121719-809.1",
"MAG": "3083916925",
"PubMedCentral": null
},
"license": "publisher-specific license",
"status": "GOLD",
"url": "https://meridian.allenpress.com/angle-orthodontist/article-pdf/90/6/851/2693385/i0003-3219-90-6-851.pdf"
}
|
OBJECTIVE
To compare second molar angulation to the occlusal plane with cephalometric measurements corresponding to AP skeletal discrepancy.
MATERIALS AND METHODS
72 patients' pre-orthodontic records were analyzed. A plane was constructed along the cusps of the upper second molar and measured to a proxy for the occlusal plane. The angle between the planes was measured. ANB, Wits appraisal, U1-SN, IMPA, A-B perpendicular to Frankfort, and overjet were measured on the patients' cephalograms. Generalized additive mixed model analysis was performed to analyze the relationship between the second molar angulation and the cephalometric measurements.
RESULTS
All six cephalometric measurements showed a significant relationship with the second molar angulation, with Class III patients having a larger angle than Class II and I patients.
CONCLUSIONS
Class III patients have upper second molars that are significantly tipped from the occlusal plane. The second molars require special attention for correction prior to orthognathic surgery for Class III patients in order to avoid deleterious effects from the malpositioned teeth.
|
2022-12-24T14:31:58.964Z
|
39,152,400 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bcr-2015-213577",
"MAG": "2340754270",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4716375?pdf=render"
}
|
We discuss a case of a 47-year-old man who presented with progressive proximal muscle weakness of the upper and lower extremities and unstable gait. He had been on etanercept for 6 months for severe psoriasis and psoriatic arthritis with good control of his disease. Serum creatine kinase (CK) level was found to be 5666 U/L and muscle biopsy showed a marked inflammatory myopathic process likely secondary to etanercept. He was started on high-dose steroids and advised to discontinue etanercept. Despite our recommendation, he never stopped using etanercept due to fear of a psoriasis flare. Three months later, he had significant improvement of clinical symptoms, normalised serum CK levels and discontinued prednisone.
|
2022-12-29T15:24:23.397Z
|
2,540,325 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0024768",
"MAG": "1979583753",
"PubMedCentral": "3173465"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024768&type=printable"
}
|
Overwhelming activation of IL-17, a gene involved in inflammation, leads to exaggerated Th17 responses associated with numerous autoimmune conditions, such as experimental autoimmune encephalomyelitis (EAE). Here we show that TCF-1 is a critical factor to repress IL-17 gene locus by chromatin modifications during T cell development. Deletion of TCF-1 resulted in increased IL-17 gene expression both in thymus and peripheral T cells, which led to enhanced Th17 differentiation. As a result, TCF-1-/- mice were susceptible to Th17-dependent EAE induction. Rag1-/- mice reconstituted with TCF-1-/- T cells were also susceptible to EAE, indicating TCF-1 is intrinsically required to repress IL-17. However, expression of wild-type TCF-1 or dominant negative TCF-1 did not interfere with Th17 differentiation in mature T cells. Furthermore, expression of TCF-1 in TCF-1-/- T cells could not restore Th17 differentiation to wild-type levels, indicating that TCF-1 cannot affect IL-17 production at the mature T cell stage. This is also supported by the normal up-regulation or activation in mature TCF-1-/- T cells of factors known to regulate Th17 differentiation, including RORγt and Stat3. We observed hyperacetylation together with trimethylation of Lys-4 at the IL-17 locus in TCF-1-/- thymocytes, two epigenetic modifications indicating an open active state of the gene. Such epigenetic modifications were preserved even when TCF-1-/- T cells migrated out of thymus. Therefore, TCF-1 mediates an active process to repress IL-17 gene expression via epigenetic modifications during T cell development. This TCF-1-mediated repression of IL-17 is critical for peripheral T cells to generate balanced immune responses.
|
2022-12-31T16:06:49.396Z
|
245,700,107 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.30971/pje.v38i2.1380",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "http://journal.aiou.edu.pk/pjeojs/index.php/PJE/article/download/1380/pdf"
}
|
AbstractThis research aims to explore the gender equality or lack thereof in the Urdu textbooks taught in Punjab, Pakistan. Gender bias in textbooks is an important but almost invisible and overlooked problem. Five Urdu textbooks taught in primary government schools in Punjab were selected for critical discourse analysis. Both qualitative as well quantitative research methods were adopted. The number of female and male characters, portrayal of domestic and professional roles by both genders, and cosmetic bias was taken into account. In all five books analyzed, 28% characters were women whereas remaining were male characters. Female characters were mostly found in domestic situations with insignificant roles in the stories who did not have a name or an identity except being mothers. The text was highly biased towards the male characters associating valor and strength with men only. Since textbooks play a crucial role in the development of the children, it is important to remove the concealed gender bias in textbooks and acknowledge the changing roles of women in the Pakistani society in order to create a society that treats men and women equally.
|
2022-01-22T01:20:43.984Z
|
129,559,499 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2298/zmsdn0621019b",
"MAG": "2037899387",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://www.doiserbia.nb.rs/ft.aspx?id=0352-57320621019B"
}
|
The following basic tendencies were noticed in the development of the population of Vojvodina: decrease in the birthrate, increase in the mortality rate and decline of the total number of the population living in the territory of Vojvodina. Migrations abroad (first to find jobs, and later due to unfavourable events in the country and war disturbances) were more pronounced, and then a strong immigrational wave from the former Yugoslav republics to Vojvodina. The paper analyzes the results of the population census from 2002 in relation to the former 1991 census, combining them with the facts about the vital statistics and the facts from the records concerning the applications for permanent residence and emigration of citizens. The strongest factor which influenced the results of the census was contained in the negative natural increase and in the higher number of the inhabitants of Vojvodina leaving to work and stay abroad. Such a situation was to a certain degree changed after the arrival of the refugee population and foreigners who work and reside in Vojvodina.
|
2022-02-09T14:40:48.471Z
|