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94,302,945 |
{
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"DOI": "10.1179/174591906X95987",
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Abstract Initial stages of copper electrodeposition on highly oriented pyrolytic graphite (HOPG) from acid sulphate solutions are studied using cyclic voltammetry and chronoamperometry. The electrolyte consisted of 0·001 mol dm−3 copper sulphate and 1·0 mol dm−3 sulphuric acid containing polyethylene glycol (PEG) and Cl−. It was found that the additives produce an initial inhibition of copper deposition, probably related to the adsorption. The initial deposition kinetics corresponded to a model including progressive nucleation and diffusion controlled growth. Addition of chloride ions and PEG did not change the initial nucleation of copper electrocrystallisation, but increased the nucleation rate and the number density of nuclei on the surface.
|
2022-09-27T08:36:45.402Z
|
98,423,640 |
{
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"DOI": "10.1021/LA00091A009",
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|
Les electrodes a pâte de graphite modifiees par de l'acide stearique presentent une bonne resolution pour l'identification de catecholamines, dopamines et norepinephrine
|
2022-10-06T06:35:06.119Z
|
252,615,868 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2022/2745946",
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"PubMedCentral": "9532098"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://downloads.hindawi.com/journals/ecam/2022/2745946.pdf"
}
|
Background Osteoarthritis (OA) is a multifactorial disease with various risk factors, resulting in the degeneration of articular cartilage and whole joints. However, to date, no effective disease-modifying therapy for OA has been developed. Oxymatrine (OMT) is associated with many pharmacological effects, including anti-inflammatory, antiapoptotic, and antioxidative properties. However, the role of OMT in OA remains unclear. Materials and Methods An IL-1β-induced chondrocyte model and anterior cruciate ligament transection (ACLT)-induced murine model of OA were constructed. The effect of OMT on chondrocyte viability was assessed using the CCK-8 assay. The protein level was assessed by Western blot analysis, and the apoptosis rate was assessed by flow cytometry in vitro and TUNEL staining in OA model mice. The effect of OMT on the degradation of articular cartilage in ACLT-induced OA mice was assessed by histological analysis. Results OMT at 0–2 mg/mL showed no conspicuous cytotoxicity on chondrocytes after 24 hours of incubation. OMT at 0.5, 1, and 2 mg/mL inhibited IL-1β-triggered apoptosis, upregulated MMP13, MMP9, and Col X, and upregulated Col II in chondrocytes in vitro. OMT represses the NF-κB signaling cascade in IL-1β-triggered chondrocytes in vitro. In an in vivo study, OMT decreased the apoptosis rate of chondrocytes and exerted a protective effect against the degradation of articular cartilage in ACLT-triggered OA mice. Conclusion OMT plays a protective role against chondrocyte injury induced by IL-1β in vitro or ACLT in vivo. OMT may play a role in chondrocytes during OA by inhibiting NF-κB signaling by decreasing the phosphorylation of p65 and IκB. OMT treatment may be a promising chondroprotective approach to delay OA cartilage progression.
|
2022-10-14T01:18:22.575Z
|
146,079,317 |
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"DOI": "10.22516/25007440.354",
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"license": "CCBYNCND",
"status": "GOLD",
"url": "https://revistagastrocol.com/index.php/rcg/article/download/354/304"
}
|
La pancreatitis crónica es un trastorno irreversible y progresivo del páncreas caracterizado por inflamación, fibrosis y cicatrización. Las funciones exocrinas y endocrinas se pierden, lo que a menudo conduce al dolor crónico. La etiología es multifactorial, aunque el alcoholismo es el factor de riesgo más importante en los adultos. Si se sospecha pancreatitis crónica, la tomografía computarizada con contraste es la mejor modalidad de diagnóstico por imágenes. Aunque los narcóticos y los antidepresivos proporcionan el mayor alivio del dolor, más de la mitad de los pacientes eventualmente requiere una intervención por endoscopia o cirugía. La colangiopancreatografía retrógrada endoscópica es una alternativa eficaz para una variedad de terapias en el tratamiento de enfermedades benignas y malignas del páncreas. En los últimos 50 años, la endoterapia ha evolucionado hasta convertirse en la terapia de primera línea en la mayoría de las enfermedades inflamatorias agudas y crónicas del páncreas. A medida que avanza este campo, es importante que los gastroenterólogos mantengan un conocimiento adecuado de la indicación del procedimiento, mantengan el volumen de procedimiento suficiente para manejar la endoterapia pancreática compleja y comprendan enfoques alternativos a las enfermedades pancreáticas, incluidos el tratamiento médico, la terapia guiada por ecografía endoscópica, el manejo de las estenosis sintomáticas y cálculos, las intervenciones sobre el plexo celíaco y el drenaje de los pseudoquistes pancreáticos.
|
2022-12-13T22:15:07.760Z
|
201,566,883 |
{
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"DOI": "10.5433/1519-5392.2018V18N2P27",
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|
Neste trabalho, faz-se uma aproximação entre os estudos dos multiletramentos e os objetos de conhecimento que constituem as provas de Linguagens, códigos e suas tecnologias, do Exame Nacional de Ensino Médio (ENEM). A base teórica está ancorada, principalmente, nos estudos dos multiletramentos em interface com os Parâmetros Curriculares Nacionais – de Ensino Fundamental (1998) e de Ensino Médio (2000) – e a Matriz de Referência do ENEM (2012). O objetivo principal é analisar questões das provas aplicadas entre os anos de 2013 a 2016, com o intuito de compreender de que forma elas contemplam conhecimentos relacionados aos multiletramentos, mais especificamente, às múltiplas semioses e tecnologias envolvidas nos processos de interação, bem como à multiculturalidade inerente às formações sociais. Das questões encontradas abordando tais conhecimentos, foram selecionadas quatro para compor o corpus deste estudo. A análise aponta que esses conhecimentos vêm imbricados, de forma implícita, nos enunciados das questões, exigindo que o leitor tenha certa familiaridade com eles para que consiga interpretá-los corretamente. Também aponta para a necessidade de, cada vez mais, elaborarem-se atividades de ensino efetivamente voltadas aos multiletramentos, com vistas a contribuir para a formação de sujeitos que possam usar os conhecimentos adquiridos na escola para melhor interagir e resolver problemas no meio social.
|
2022-12-18T23:00:34.356Z
|
186,801,625 |
{
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"DOI": "10.22034/AIMJ.2020.119802",
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}
|
فناوری اطلاعات و ارتباطات (ICT)، میتواند از طریق سازماندهی مجدد فرایندهای تولید به روشهای کاراتر، رشد اقتصادی را افزایش دهد. نتایج اغلب پژوهشها، گویای تأثیر مثبت و معنادار فناوری اطلاعات و ارتباطات بر رشد اقتصادی کشورهای توسعهیافته در دهه 1990 است. یافتههای بعضی از پژوهشها، این رابطه مثبت را در کشورهای در حال توسعه نیز تأیید کردهاند؛ اما این موضوع برای کشورهای منتخب منا با توجه به ویژگیهای نامتوازن و ضعیف زیرساختی آنها، جای بررسی دارد. از این رو، هدف اصلی پژوهش حاضر، بررسی تأثیر فناوری اطلاعات و ارتباطات، سرمایهگذاری مستقیم خارجی (FDI) و مخارج عمومی دولت بر رشد اقتصادی کشورهای منتخب منا، طی سالهای 1377 تا 1398 است. برای تحلیل موضوع، از مدل گشتاورهای تعمیم یافته (GMM) استفاده شده است. نتایج پژوهش نشان داد که اثر فناوری اطلاعات و ارتباطات بر رشد اقتصادی مثبت و معنادار است، اثر متغیر سرمایهگذاری مستقیم خارجی بر رشد اقتصادی مثبت است؛ اما از لحاظ آماری معنادار نیست و تأثیر مخارج عمومی دولت بر رشد اقتصادی منفی و معنادار است. گفتنی است که اثر سایر متغیرهای مدل، نظیر شاخص شفافیت بینالمللی (IT)، درجه باز بودن تجارت (GOPEN) و نرخ سرمایه داخلی هر کارگر (GKD)، از لحاظ آماری معنادار نبوده است.
|
2022-01-24T19:36:49.104Z
|
234,160,481 |
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"DOI": "10.30465/CRTLS.2021.6000",
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|
اصل جریان اطلاعات که نام دیگر آن تبادل اطلاعات است، در حوزه حقوق بین الملل مالیاتی نیز به رسمیت شناخته شده و ابزارها و مکانیزم هایی برای تحقق آن در نظر گرفته شده است. از جمله این مکانیزم توافق نامه های تبادل اطلاعات مالیاتی می باشد، با جهانی شدن حقوق بین الملل مالیاتی فعالیت های مالیات دهندگان دیگر محدود به مرز مشخصی نیست ولی ادارات مالیاتی همچنان به مرز های خود محدود شده اند لذا دولتها به همکاری های بیشتری با یکدیگر نیازمند هستند . لازمه ی این همکاری ها تبادل اطلاعات مالیاتی به اشکال مختلف از جمله تبادل به درخواست، تبادل خودکار وتبادل خودجوش اطلاعات می باشدکه این امر از طریق انعقاد معاهدات بین المللی دوجانبه وچند جانبه میسر میگردد. در این نوشتار با بررسی نقادانه موافقت نامه های نمونه تبادل اطلاعات مالیاتی به روشی توصیفی و تحلیلی می توان به انعقاد سندی مناسب برای راه اندازی تبادل اطلاعات بین دو کشور با سیستم های مختلف مالیات بر درآمد امیدوار بود.
|
2022-01-27T09:45:57.971Z
|
153,851,832 |
{
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"DOI": "10.1111/J.1752-1688.1980.TB02399.X",
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|
: The Federal Government's interest and involvement in water resource development in discussed in the context of project financing and cost sharing. After drawing a clear distinction between the two issues - who puts up the money, and who repays over time - the authors survey a number of Federal acts from which have evolved nearly 200 separate cost-sharing rules. Selected cost sharing and financing issues discussed include consistency in policies, rehabilitation of urban water supply systems, multipurpose water quality projects, and ground water management. Two proposals for cost/finance sharing reform introduced in the 96th Congress are discussed in detail and their impacts compared with current policy. The joint venture approach (Administration proposal) results in an effective composite cost share which changes significantly but not drastically (from 19 to 35 percent non-Federal share for a hypothetical project). The block grant approach (Domenici-Moynihan proposal) would alter the regional distribution of Federal water developement funding from the South and West to the Northwest and North Central States.
|
2022-03-28T17:43:49.954Z
|
239,717,384 |
{
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"ArXiv": null,
"DOI": "10.1002/sdtp.15119",
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|
Autonomous robots become increasingly widespread in public spaces. Human‐robot interactions (HRI) with pedestrians is essential by visualizing trajectory information. We evaluated various display technologies for bright indoor conditions such as animated projection and LED lighting as well as displays.
|
2022-04-04T23:46:04.687Z
|
96,705,183 |
{
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"ArXiv": null,
"DOI": "10.1063/1.431578",
"MAG": "2088420413",
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|
A number of time‐dependent absorption phenomena in laser‐pumped infrared‐microwave double resonance in ammonia have been studied in detail. A Stark‐modulated, infrared‐laser enhanced transient nutation experiment permits simultaneous measurement of both T1 and T2 for the (8,7) microwave inversion doublet. The result is 1/2πT1 = [(25.4±2.0) p+0.028] MHz and 1/2πT2=[(24.5±2.0) p + 0.087] MHz, where p (NH3) is in torr. Four‐level double‐resonance experiments allow a separate measurement of the inversion relaxation rate in the (9,7) absorption doublet, which is kβ= (12±3) ×106 sec−1⋅torr−1. The effect of partial saturation within the infrared Doppler velocity profile has also been investigated.
|
2022-08-30T09:15:48.755Z
|
102,362,939 |
{
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"ArXiv": null,
"DOI": "10.1071/CH9681807",
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|
Theoretical considerations indicate that the electron distribution in 3,4,-dimethylenecyclobutene is non-uniform and a dipole moment of 0.71 D has been predicted by inclusion of non-neighbour core resonance integrals. Preliminary studies of the microwave spectrum of this compound provide a dipole moment of 0.618 ± 0.011 D. The term "pseudo-alternant" is proposed to describe this phenomenon. In the present paper additional physical and chemical properties of 3,4,-dimethylene- cyclobutene are described. The observed low-field proton chemical shifts for 3,4-dimethylenecyclobutene are not accounted for using a ring current model and a small calculated paramagnetic current indicates properties usually associated with Huckel 4n-hydrocarbons. A local anisotropy model provides a better account of the observed shift. The carbon-13- proton satellite spectrum of 3,4-dimethylenecyclobutene indicates similarities in the geometry of the four-membered ring to that in cyclobutene. In addition, infrared and ultraviolet spectra support the conclusion that this hydrocarbon be regarded as a cross-conjugated diene. A detailed discussion of the products arising from the bromination of 3,4-dimethylenecyclobutene under a variety of conditions indicates consecutive 1,4-addition of bromine across the four-membered ring, a property which has been associated with cross-conjugation. Hydrogenolysis, chlorination, iodination, and attempted Diels-Alder addition reactions are also described. 3,4-Dimethylenecyclobutene was prepared by the thermal rearrangement of hexa-1,5-diyne. The mechanisms of thermal and photolytic rearrangement of hexa-1,5-diyne are discussed using Woodward-Hoffmann postulates. 1,2-Dideutero-,1-ethyl-, and 1-n-propyl-3,4-dimethylenecyclobutene were also prepared by the thermal rearrangement of the corresponding diyne. In addition, the thermal rearrangement of hexa-1,5-diyne over the temperature range 290-700o to give variable quantities of 3,4-dimethylenecyclobutene, fulvene, and benzene is described. 3,4- Dimethylenecyclobutene is thermally rearranged to benzene at 680o.
|
2022-09-14T19:21:50.035Z
|
31,114,831 |
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"DOI": "10.1371/journal.pntd.0006033",
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"PubMedCentral": "5667887"
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"status": "GOLD",
"url": "https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006033&type=printable"
}
|
Background Mass drug administration (MDA) using praziquantel is the WHO-recommended approach for control of schistosomiasis. However, few studies have compared the impact of different schedules of MDA on the resultant infection levels. We wished to evaluate whether annual MDA was more effective than less frequent treatments for reducing community-level prevalence and intensity of Schistosoma mansoni infections. Methods We performed a cluster randomized trial (ISRCTN 14849830) of 3 different MDA frequencies over a 5 year period in 75 villages with moderate (10%-24%) initial prevalence of S. mansoni in school children in western Kenya. Praziquantel was distributed by school teachers to students either annually, the first 2 years, or every other year over a 4 year period. Prevalence and intensity of infection were measured by stool examination in 9–12 year old students using the Kato-Katz method at baseline, each treatment year, and for the final evaluation at year 5. S. mansoni prevalence and intensity were also measured in first year students at baseline and year 5. Results Twenty-five schools were randomly assigned to each arm. S. mansoni prevalence and infection intensity in 9–12 year old students significantly decreased within each arm from baseline to year 5 but there were no differences between arms. There were no differences in infection levels in first year students either within or between arms. Conclusions Strategies employing 2 or 4 rounds of MDA had a similar impact in schools with moderate initial prevalence, suggesting that schistosomiasis control can be sustained by school-based MDA, even if provided only every other year.
|
2022-10-21T00:27:45.765Z
|
87,278,975 |
{
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"DOI": "10.1071/PP9820423",
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|
Wheat (cv. Sun 9E) and barley (cv. Clipper) plants were subjected to water deficit after anthesis. In both species grain dry matter accumulation was initially unaffected by water deficit but terminated earlier in stressed plants than in controls. Water deficit did not affect endosperm cell number. In water stressed wheat plants the number of B-type starch granules per endosperm and the size of the largest A-type granules were significantly less than in control plants but A-type granule number was unaffected. Water potentials of wheat flag leaves and bracts were reduced by water deficit but this treatment did not affect grain water potential or osmotic potential during the first 29 days after anthesis. During these 29 days, neither grain nor bract water potential of barley was affected by stress and the water potential of bracts was relatively low even in control plants. Maturing grains eventually lost water and endosperm volume declined. This water loss occurred earlier in stressed plants. Stress significantly reduced the amount of sucrose per wheat grain but not the amount of sucrose per unit of grain dry matter or water content. In barley grains, stress did not reduce the relative or absolute sucrose contents. It was considered unlikely that the earlier cessation of grain growth on stressed plants was caused by insufficient assimilate. Although protein as a proportion of grain dry weight was higher in stressed plants than in controls, protein and amino acid content per grain were unaffected by water deficit.
|
2022-12-21T08:42:01.223Z
|
85,214,869 |
{
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"DOI": "10.1080/09712119.1997.9706199",
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|
Abstract Pahar, B. and Rai, A. 1997. Immunogenicity of infectious bursal disease strains isolated in India. J. Appl. Anim. Res., 12: 137–144. Out of the three isolates of infectious bursal disease virus (IBDV), only IBDV S394 gave 100% protection in birds without any immunosuppressive effect and mortality in day old chicks, while IBDV S494 and IBDVS194 gave 88% and 76% protection, respectively. Thus IBDV S394 may serve as prophylactic agent against infectious bursal disease in poultry.
|
2022-12-26T20:00:09.125Z
|
161,212,183 |
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"DOI": "10.1093/cr/51.1.145",
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|
Sociologically informed approaches to Roman history and archaeology are increasingly common, and have encouraged scholars to see the Roman Empire as much a state of mind as a political and institutional framework. The Theoretical Roman Archaeology Conferences have played an important rôle in this trend, and this book draws papers from sessions on acculturation and cultural identity held in the 1995 meeting. Most of these studies are concerned with the impact the creation of the Roman Empire had on the culture and identity of its inhabitants. In the useful introduction, Laurence observes that they show cultural identity to be a complex and malleable construct in the Roman Empire. This undermines dualistic ideas of Romans vs. natives and resistance or cooperation, which were inherent in a nineteenth-century world view, and which have dominated studies of the Roman Empire until comparatively recently. Identity and cultural change certainly deserve to occupy a central place in our understanding of the nature of the Roman Empire, and the appreciation of their importance has led both archaeologists and historians to focus on these issues. The papers in this collection range from traditional archaeological investigations like Isserlin’s examination of the use of marble in the buildings of Roman Britain to Braund’s illuminating study of the literary discourses concerning the entourage of Roman governors. No paper is entirely successful in bringing together archaeological and literary material; the closest to this, Van Dommelen’s ambitious interpretation of μeld survey evidence from western Sardinia, ultimately forces the ambiguous evidence of pottery types into a largely literary framework of cooperation and resistance with the imperial powers of Rome and Carthage (pp. 25–48). This is disappointing, given the success of some exemplary recent studies, such as E. Dench, From Barbarians to New Men (Oxford, 1995), or G. D. Woolf, Becoming Roman (Cambridge, 1998), in interrogating the two types of material side by side. I also doubt the usefulness of ‘cultural identity’ as a guiding concept, as it suggests a straightforward and intimate connection between culture and identity. This is e¶ectively problematized by Grahame, who explores the tremendous di ̧culty in separating out social, political, and ethnic in·uences on cultural features, although his analysis of debates on style o¶ers no clear solution to these problems (pp. 156–78). The diversity of evidence used, combined with the short length and geographical speciμcity of most papers (the focus is largely on the western Empire, and particularly on Roman Britain), makes for a heterogeneous collection. Despite the woolly, allencompassing character of ‘cultural identity’, some themes do emerge which are illustrated by more than one paper. Unlike modern nationalist identities, the nature of ‘Romanness’ was elusive and continually evolving. Using Wallace-Hadrill’s work on Pompeii, Grahame develops an interesting model of a continually adapting upper class always striving to stay one step ahead of its socially inferior emulators. Any attempt to measure the Romanization of the provinces against Italy must incorporate this idea of a shifting target (Grahame, p. 176), although this is not in itself a crucial objection to the existence of such change (A. Woolf, p. 111). Local identities emerge as similarly malleable (see Laurence on Patavium, pp. 104–5), demonstrating that identity was dynamic and ·uid at every level in the imperial system. The Empire also 145
|
2022-02-08T22:20:52.213Z
|
246,936,193 |
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"DOI": "10.47689/2181-1415-vol2-iss10/s-pp366-371",
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"license": "CCBY",
"status": "HYBRID",
"url": "https://www.inscience.uz/index.php/socinov/article/download/1378/1580"
}
|
Мақолада Ўзбекистон Республикасида бюджет жараёнининг ижро этилишида Ўзбекистон Республикаси Олий Мажлис Қонунчилик Палатаси ва Сенатга берилган ваколатларнинг қонунчилик таҳлили келтирилиб, бунда парламент томонидан бюджет ижросининг назорат қилиниши шакллари, депутатлар ва сенаторларнинг ушбу назорат жараёнларидаги иштироки масалалари келтирилган. Ундан ташқари, бюджет ижроси жараёнида вужудга келаётган муаммолар ўрганилиб, ушбу муаммоларни бартараф этиш юзасидан қонунчиликка депутатлар ва сенаторларнинг парламент назорати субъектлари сифатида давлат ва бошқарув органларига сўров юбориш тартиби юзасидан қонунчиликка таклифлар асослантирилган.
|
2022-02-25T01:06:55.722Z
|
84,538,991 |
{
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"DOI": "10.3398/064.073.0113",
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"license": null,
"status": "GREEN",
"url": "https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=1340&context=wnan"
}
|
ABSTRACT.
Descriptions of previously undescribed taxa are provided for plant taxa from Colorado (Phacelia), New Mexico (Phacelia; Mentzelia), and Arizona (Xylorhiza).
|
2022-05-20T06:49:47.108Z
|
54,208,316 |
{
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"ArXiv": null,
"DOI": "10.23919/EUSIPCO.2018.8553297",
"MAG": "2902331361",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The DNA from several organisms is sequenced conjointly in metagenomics. This allows searching for exogenous microorganisms contained in the samples, with the goal of studying the evolution and co-evolution of host-pathogen, namely for building better diagnostics and therapeutics. However, the quantity and quality of the DNA present in the samples is very poor, pushing the responsibility of analysis improvements into the development of better computational methods. Here, we develop a new processing paradigm to infer the metagenomic composition analysis based on the relative compression of whole genome sequences. Using this method, we present the metagenomic composition analysis of a sedimentary ancient DNA sample, dated to 8,000 years before the present, from the Isle of Wight, United Kingdom. The results show several viruses and bacteria expressing high levels of similarity relative to the samples, namely a circular virus similar to the Avon-Heathcote estuary virus 14 sequenced in New Zealand.
|
2022-09-14T17:35:53.181Z
|
238,697,716 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25236/IJNDES.2021.050205",
"MAG": "3194457158",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cultural tourism is an important part of the tertiary industry, and cultural tourism is known as the most promising way of tourism. Zhaoqing is rich in cultural tourism resources, but its cultural tourism development is still in its primary stage. In this paper, for the purpose of integrating and sharing tourism resources in Zhaoqing, a system model of cultural tourism industry based on Web services is proposed by using artificial intelligence (AI) and intelligent media technology, which can effectively realize information exchange, data sharing and online transaction of tourism products, and proposes to combine them to form a comprehensive service platform, so that tourism consumers can really enjoy one-stop service. The realization of this system is of great significance to the development of regional tourism.
|
2022-09-16T15:55:08.671Z
|
133,936,967 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/iar.12214",
"MAG": "2736423201",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Detailed diatom records within core sediments from Maeho Lagoon along the Eastern coast of South Korea revealed that the ecological dynamics of the lagoon during the Holocene were associated with relative sea level and regional precipitation. Accelerator mass spectrometry (AMS) 14C dating indicates that sediment accumulation began prior to 8300 cal. year BP, and that the lagoon formed around 8000 cal. year BP. The salinity level of the lagoon increased until 5000 cal. year BP, and then decreased. Long‐term trends in salinity were dependent upon changes in sea level: periods of high salinity in the lagoon were generally coincident with periods of high sea levels along the east coasts of Korea and Japan. On the other hand, multicentennial‐scale fluctuations in diatom assemblages and magnetic susceptibility (MS) suggest that a 400 year fluctuation in salinity was regulated by changes in precipitation in the area of this lagoon. Changes in the westerly jet stream, controlled by variation in solar irradiance, had an important influence on precipitation volume in South Korea, suggesting that the patterns of the westerly jet stream fluctuate on a 400 year cycle.
|
2022-11-18T14:57:50.655Z
|
21,211,456 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/BIOF.5520180210",
"MAG": "1969398411",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Energy starvation of the myocardium is probably a dominant feature of heart failure and attention has been directed towards agents which may stabilize myocardial metabolism and maintain adequate energy stores. A reduced myocardial tissue content of the essential redox‐component and natural antioxidant Coenzyme Q10 (CoQ10) has been detected in patients with heart failure and the observed level of CoQ10 deficiency was correlated to the severity of heart failure.
|
2022-12-03T00:42:56.148Z
|
155,360,877 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/13563475.2015.1114449",
"MAG": "2207805563",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT A growing body of literature suggests that the segregation of infrastructure and urban/regional planning is at the root of contemporary problems facing many of the world's metropolitan areas. More recently, the introduction of new telecommunication infrastructure highlights the invisible borders that exist within critical infrastructure that provide advantages to some areas such as transportation and disadvantages to others. This paper attempts to understand the nature of inter-sectoral and intra-sectoral borders across infrastructure in Australia and the US. It examines the sometimes contradicting market-led vs. government-led models adopted in the two countries to deliver broadband communications and transportation. The findings identify similarities and differences between the two countries, and reiterate that in order to achieve social equity, and enhance the provision of infrastructure to non-profitable areas, government intervention is required. The paper concludes with a call for performance-based policies that go beyond traditional borders in an effort to better address the contemporary wicked planning problems.
|
2022-12-10T12:28:18.947Z
|
57,055,029 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/ARCHDISCHILD-2012-301885.105",
"MAG": "2035520688",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Aims The literature on the associations between breastfeeding and eczema prevalence is conflicting. Early reviews of the literature found that breastfeeding was associated with a reduced risk of eczema, but several recent studies have suggested that breastfeeding may increase the risk of atopic disorders at older ages. A positive association between breastfeeding and eczema risk might reflect reverse causation (longer breastfeeding of at risk children in response to early eczema symptoms). However, few studies have been able to account for the influence of early atopic symptoms on the association between breastfeeding and eczema. Here, we investigate the association between breastfeeding duration and eczema accounting for the effect of early rash on breastfeeding practice. Methods This study used data collected as part of the Avon Longitudinal Study of Parents and Children, a geographically-based cohort study of children born in the Bristol area in 1991-92. Information on breastfeeding duration was obtained prospectively by questionnaire, information on early eczema (up to age 42 months) was obtained by parental report of rash at two time points in questionnaires completed at 6, 18, 30 and 42 months post-natal. Information on eczema at age 7-8 year was from observations of flexural dermatitis at research clinics attended by children at this age. Results Table 1 shows the odds ratios for early eczema according to duration of breastfeeding. Risk of early eczema was significantly higher in ever versus never breastfed children (OR 1.43 95% CI 1.26, 1.61), and there was evidence of increased eczema risk with increasing breastfeeding duration. This association persisted on adjustment for potential confounders including parental education and history of atopy, and on exclusion of children with symptoms of rash in the first six months. There was a similar association with late eczema in unadjusted analysis, but this was lost on adjustment for potential confounders. Conclusion In this study we found no evidence that breastfeeding protects against eczema. On the contrary there was more early eczema among infants breastfed for longer. This association was not explained by changes in breastfeeding practice associated with parental atopy or with symptoms of rash in the first six months.
|
2022-12-12T15:12:47.110Z
|
18,020,593 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICCI-CC.2015.7259362",
"MAG": "1506477080",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The significant law of information conversion and intelligence creation, which is also a unified theory of information, knowledge and intelligence, is discovered recently and is presented in the paper for the first time. It is the author's belief that the law reported is of great significance to the understanding of the essence of Information Science, and of the information age as well.
|
2022-02-13T00:07:35.245Z
|
111,022,923 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1098/RSPA.1929.0064",
"MAG": "2059958134",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
It has long been a common practice to cover accumulator terminals with vaseline; Price and others at a discussion at the Physical Society mentioned that potentiometer contacts were improved by immersion in kerosine oil; Manley found that the resistance of the plugs in a resistance box was invariably more constant and very nearly always lower when they were lubricated with vaseline than when they were dry; Kraus, and Melsom and Booth in investigations upon contact resistances, such as switches for electrical machinery, obtained similar results. Vaseline and heavy paraffin oil are now widely used for application to plugs and sliding contacts on measuring instruments. In view of the fact that these substances are ordinarily regarded as excellent insulators, their use for the above purpose appears somewhat anomalous, and the object of the present investigation is a detailed examination of the region in which a transition from insulation to conduction appears to take place.
|
2022-04-22T04:49:18.973Z
|
54,337,012 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0030605308423153",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Subject Index
|
2022-08-31T02:44:32.437Z
|
196,965,721 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/CHIN.198818234",
"MAG": "2952499045",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The aldehydes or ketones (I) react with trimethylsilyl cyanide (II) or the ketene silyl acetal (V) in the presence of lanthanide trichlorides, producing mixtures of the α-hydroxy nitriles (III) and the α-siloxy derivatives (IV) or of the β-hydroxy/β-siloxy esters (VI) and (VII).
|
2022-02-08T06:48:48.288Z
|
39,213,521 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IAEAC.2017.8053975",
"MAG": "2760635882",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
For modern high performance fighter with a fly-by-wire control system, pitch rate signal is the key feedback for proper damp characteristic of pitch movement. Once the signal sensor of pitch rate fail, the longitudinal dynamic characteristics of closed-loop aircraft will be obviously deteriorated, even become unstable. So it is necessary to study on the signal reconstruction method in case of failure of pitch rate sensor. Based on the flight dynamics equation, a signal reconstruction method is established by combining other key flight variables' signal. Besides, using the six-degree simulation model of a relaxed static stability fighter, simulation and calculation is conducted to prove the method effective. The result indicates that although the reconstructed pitch rate signal obtained with the designed method has almost the same shape as the real signal, there also exists additional time delay and phase lag, which makes damping ratio of closed-loop aircraft a bit lower. Generally speaking, the designed signal reconstruction method is practical.
|
2022-02-12T05:25:56.854Z
|
72,057,103 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/JAMA.1898.02440550049016",
"MAG": "2014064038",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Chicago Eye, Ear, Nose and Throat College. Chicago, Ill., Dec. 14, 1897.To the Editor: —In the N. Y. Medical Record of November 27, is given a copy of a circular letter recently issued by the New York Cancer Hospital, which is sent to the family physician of all patients applying to their clinics for free treatment, in which inquiry is made as to the ability of the patient to pay. In all cases wherein it is learned that the patient is able to pay further clinical services are denied.The same idea was adopted by the Chicago Eye, Ear, Nose and Throat College several months earlier as may be seen by appended copy of letter issued at the time of its organization, to every doctor in Cook County.Would it not be just to place the credit for the idea where it belongs, and give us the precedence of
|
2022-05-27T00:36:51.722Z
|
93,950,103 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1246/CL.1979.1349",
"MAG": "1984552273",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Iron(II) chloride reacts with a mixture of lithium cyclopentadienide and dilithium as-indacenide in tetrahydrofuran to give asindacenebis(cyclopentadienyliron) (1). The results of NMR and solubility studies of (1) indicate that (1) is one of the new analogues of biferrocene or cyclopentadienyl(indenyl)iron rather than that of bis(as-indacenyliron).
|
2022-08-27T06:13:44.405Z
|
1,858,250 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmj.308.6926.470",
"MAG": "2013669009",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc2539495?pdf=render"
}
|
EDITOR, - I was disappointed that the World Health Organisation-International Society of Hypertension placed such little emphasis on the impact of metabolic factors on the management of essential hypertension.1 Insulin insensitivity accompanying hypertension is associated with established or subsequent dyslipoproteinaemia (low high density lipoprotein cholesterol concentration, hypercholesterolaemia, and hypertrigly-ceridaemia) and glucose intolerance in at least 30% of patients.2,3 These disturbances will be compounded by treatment with preparations that combine a thiazide with a β blocker, leading to an 11-fold increased incidence of diabetes over the following 10 years.4
Although the published guidelines recommend treatment with a diuretic in combination with a β blocker for mild hypertension,1 they contain no suggestion that screening for metabolic dysfunction should be routine in the work up of hypertensive patients as an aid to the selection of appropriate pharmacological treatment. Nor is the need for continued surveillance for the development of diabetes mentioned. This seems paradoxical since the paper acknowledges that “serious cardiovascular disease is also determined by . . . diabetes, dyslipidaemia, central obesity.”
I suspect that I am not alone in frequently stopping treatment with a preparation combining a thiazide with a β blocker in patients recently diagnosed as diabetic who are overweight or elderly and have antecedent hypertension; this often leads to improved metabolic control.
The introduction of the paper states that guidelines should provide critical and balanced information on benefits and limitations of the various therapeutic interventions. These guidelines seem …
|
2022-09-06T10:54:30.458Z
|
219,155,440 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31851/INDIKTIKA.V2I1.3395",
"MAG": "2990953170",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Penelitian ini bertujuan untuk menghasilkan soal matematika tipe HOTS yang valid dan praktis yang dapat digunakan untuk mengukur penalaran siswa. Pengembangan soal HOTS ini dibuat dengan menggunakan beberapa konteks budaya dari berbagai daerah Jawa Timur, diantaranya daerah Nganjuk, Jawa, Malang, dan Madura. Jenis penelitian yang digunakan adalah penelitian pengembangan. Model yang digunakan adalah model pengembangan tipe formative research Tessmer, yaitu preliminary dan tahap formative evaluation yang terdiri dari self evaluation , prototyping (expert review , one-to-one , dan small group ), serta field test . Subjek pada one to one sebanyak 3 siswa kelas V Imam Bonjol, subjek pada small group sebanyak 6 siswa kelas V Imam Bonjol, dan subjek pada field test sebanyak 28 siswa kelas V Diponegoro SD Sunan Giri Ngebruk. Berdasarkan hasil penelitian, diperoleh instrumen tes yang valid, dengan kriteria tinggi yaitu 4,33 dan reliabel dengan kriteria tinggi yaitu nilai 0,85. Hasil rata-rata tingkat kesukaran soal 0,67 dengan kategori sedang, dan hasil rata-rata daya pembeda 0,34 dengan kategori baik. Dari field test , hasil rata-rata kemampuan penalaran siswa 67,85 dengan kategori cukup., terdapat 7 siswa (25%) memiliki kemampuan penalaran sangat baik, 7 siswa (25%) memiliki kemampuan penalaran baik, 3 siswa (10,71%) memiliki kemampuan penalaran cukup, dan 11 siswa (39,29%) memiliki kemampuan penalaran kurang. Kata k unci : pengembangan, soal tes, kemampuan penalaran ABSTRACT This study aims to produce mathematical problems that are valid and practical HOTS types that can be used to measure student reasoning. The development of the HOTS question was made using several cultural contexts from various regions of East Java, including the Nganjuk, Java, Malang and Madura regions. This type of research used is development research. The model used is the Tessmer formative research type development model, which is the preliminary and formative evaluation stage which consists of self evaluation, prototyping (expert review, one-to-one, and small groups), and field tests. Subjects in one to one were 3 students in grade V Imam Bonjol, subjects in small group were 6 students in grade V Imam Bonjol, and subjects in the field test were 28 students in grade V Diponegoro SD Sunan Giri Ngebruk. Based on the results of the study, obtained a valid test instrument, with a high criterion of 4.33 and reliable with a high criterion of 0.85. The average results of the level of difficulty of 0.67 in the medium category, and the average yield of 0.34 in the good category. From the field test, the average results of students reasoning ability 67.85 with enough categories. There are 7 students (25%) have very good reasoning abilities, 7 students (25%) have good reasoning abilities, 3 students (10.71% ) have sufficient reasoning ability, and 11 students (39.29%) have less reasoning ability. Keywords : development, test questions, reasoning ability
|
2022-11-08T16:38:21.716Z
|
16,956,928 |
{
"externalids": {
"ACL": null,
"ArXiv": "1409.0897",
"DOI": "10.1021/jp508866h",
"MAG": "2053619783",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1409.0897"
}
|
Molecular dynamics simulations of water with both multi-Kr and single Kr atomic solutes are carried out to implement quasi-chemical theory evaluation of the hydration free energy of Kr(aq). This approach obtains free energy differences reflecting Kr-Kr interactions at higher concentrations. Those differences are negative changes in hydration free energies with increasing concentrations at constant pressure. The changes are due to a slight reduction of packing contributions in the higher concentration case. The observed Kr-Kr distributions, analyzed with the extrapolation procedure of Krüger et al., yield a modestly attractive osmotic second virial coefficient, B2 ≈ -60 cm(3)/mol. The thermodynamic analysis interconnecting these two approaches shows that they are closely consistent with each other, providing support for both approaches.
|
2022-12-09T05:24:10.879Z
|
104,316,008 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ACS.MACROMOL.8B02403",
"MAG": "2909742789",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The synthesis of isocyanurate-free, linear poly(oxazolidin-2-one)s starting from diepoxides and aromatic as well as aliphatic diisocyanates is reported. N-Heterocyclic carbenes (NHCs), liberated in situ from thermally labile CO2 adducts, in combination with Lewis acids of the simplest kind (metal halides such as LiCl and MgCl2) were employed in a cooperative manner to prepare linear polymers with molecular weights (Mn) ranging from 6 to 50 kg/mol. Crucially, it is demonstrated that action of either NHC (Lewis base) or metal halide (Lewis acid) alone entails the formation of significant amounts of trimerized isocyanates (isocyanurate) and concomitant gelling of the thus cross-linked material, highlighting the advantages of a cooperative, dual catalytic approach. Reactions were conducted at 200 °C with low NHC loadings (0.5 mol %) to deliver isolated yields of 60–90% within 3–8 h polymerization time. Investigations regarding regioselectivity revealed that exclusively 5-substituted oxazolidin-2-one was forme...
|
2022-12-13T10:30:16.038Z
|
30,857,628 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1053/AJEM.2000.18051",
"MAG": "2123136537",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
High-pressure injection injury hides the true extent of the lesions behind an apparent small and harmless puncture of the finger or the hand. Through clinical description, we wish to point out the need for prompt treatment to avoid mutilating and function-threatening complications. We wish to outline the role of the emergency physician who must be aware of the incidence of high-pressure injection injury and become accustomed to early referral to a surgeon, experienced in extensive surgical exploration, removal of foreign bodies, and rehabilitation. The open-wound technique gives the best results. We also point out that failure to refer may become an increasing focus of negligence claims.
|
2022-12-19T06:52:55.676Z
|
234,747,008 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/17512433.2021.1925538",
"MAG": "3162450586",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://doi.org/10.1080/17512433.2021.1925538"
}
|
ABSTRACT Purpose To characterize the effect of glasdegib on cardiac repolarization (QTc) in patients with advanced cancer. Methods A concentration–QTc model was developed using data from two glasdegib single-agent, dose-escalation trials. Triplicate electrocardiogram was performed at pre-specified timepoints paired with pharmacokinetic blood collections after a single dose and at steady-state. Changes in QTc from baseline were predicted by model-based simulations at the clinical dose (100 mg QD) and in a supratherapeutic setting. Results Glasdegib did not affect the heart rate, but had a positive effect on the corrected QT interval, described by a linear mixed-effects model with ΔQTcF (QTc using Fridericia’s formula) as the dependent variable with glasdegib plasma concentrations from doses of 5–640 mg QD. The predicted mean QTcF change (upper bound of the 95% CI) was 5.30 (6.24) msec for the therapeutic 100-mg QD dose; at supratherapeutic concentrations (40% and 100% increase over the therapeutic Cmax), it was 7.42 (8.74) and 12.09 (14.25) msec, respectively. Conclusions The relationship of glasdegib exposure and QTc was well characterized by the model. The effect of glasdegib on the QTc interval did not cross the threshold of clinical concern for an oncology drug. Trial registration ClinicalTrials.gov ID: NCT01286467 and NCT00953758.
|
2022-12-30T00:23:49.443Z
|
139,801,237 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/EPJCONF/201819004001",
"MAG": "2892701073",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Atomic-scale colour centres in bulk and nanocrystalline SiC are promising systems for quantum photonics compatible with fiber optics, quantum information processing and sensing at ambient conditions. Colour centres which acts as stable single photon sources in SiC can be key elements for quantum photonics and communications. It has been shown that there are at least two families of colour centres in SiC with S = 1 and S = 3/2, which have the property of optical alignment of the spin levels even at room temperature and above. The spin state can be initialized, manipulated and readout by means of optically detected magnetic resonance (ODMR), level anticrossing and cross-relaxation. Recently, we observed the effects of “hole burning” in the ODMR spectra, which made it possible to narrow the ODMR line by approximately an order of magnitude, which substantially increases the possibilities of technological applications of spin centres.
|
2022-01-27T02:15:37.262Z
|
210,837,390 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4108/eai.2-8-2019.2290523",
"MAG": "2999276975",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://eudl.eu/pdf/10.4108/eai.2-8-2019.2290523"
}
|
Predicting stock market trend is one of the challenging tasks over the years. It has diverse influencing’s factors which cause stock market trend is very dynamic and has high volatility. Forecasting model, which is a prevalent method to predict the stock market trend, has several difficulties with its characteristics. Although forecasting model is efficient, sometimes it has high forecasting error. Formulating forecasting problem into a classification problem might be considered an alternative approach to predict stock market trend. Several kinds of research have shown that machine learning is a suitable method for predicting stock market trend as a classification problem. This paper discusses applying one of powerful machine learning method, which is called Super learner, to predict stock market trends. Besides, this research employs several technical indicators as predictor variables. Results show that the Super Learner model is useful for predicting both the short-term and long-term trend.
|
2022-01-27T05:31:58.236Z
|
247,587,324 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1353/jch.2021.0009",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract:Enslaved people in Jamaica staged a series of insurrections from 1760 to 1766 that challenged British colonial authority. Much attention has been paid to the first and largest of these insurrections, popularly known as Tacky's Revolt. Far less has been written about a subsequent event from 1765. Although minor in scope and impact, Blackwall's Revolt is important because it resulted in an unusually detailed textual archive. This archive provides a unique opportunity to see how planters forced their knowledge of slave revolt into established narratives, meant to advance the politics of colonial society. The following article examines that process through discussions of rebel leadership, gendered resistance, and slave–Maroon alliance.
|
2022-03-24T18:00:54.119Z
|
250,675,584 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1742-6596/223/1/012044",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/223/1/012044"
}
|
Superconductor-ferromagnet thin film heterostructures in lateral geometry were prepared to study the long-range proximity effect. The high temperature superconductor YBa2Cu3Ox (YBCO) as superconductive electrode and La0.67Sr0.33MnO3 (LSMO) as ferromagnetic separation were used. The length of the ferromagnetic layer between two YBCO microstrip electrodes was about 3 μm. The temperature dependence of the resistance of these structures was measured. The results obtained showed that the separation of the superconducting YBCO microstrips is too large for observation of a long-range proximity effect; further optimization of the structures is, therefore, needed.
|
2022-07-21T11:13:23.139Z
|
24,039,969 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1600-051X.1993.TB00389.X",
"MAG": "2029237667",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Non-steroidal anti-inflammatory drugs (NSAIDs) have been used as systemic and topical preparations to control chronic periodontal disease in both animal and clinical human trials. Equivocal findings have failed to confirm whether any one NSAID is particularly efficacious, although flurbiprofen appears to be one of the most promising. 49 patients were allocated at baseline to test (25) and control (24) groups in a 12-month, controlled clinical trial. The groups were of similar age and sex distributions. During the first 3 months, both groups were given oral hygiene instruction and received scaling and root planning. The test patients were prescribed a 1% w/w flurbiprofen toothpaste to use 2 x daily for the entire 12 months. Control subjects were prescribed a placebo dentifrice. Plaque scores, bleeding scores, crevicular fluid flow, probing pocket depths and attachment levels were assessed at baseline and at 3, 6, 9 and 12 months. Radiographs were taken at baseline and 12 months using a modified intraoral, repositionable film holder. Both the flurbiprofen and placebo showed significant improvements in the clinical parameters over 12 months and there were no significant differences between the groups. Flurbiprofen-treated patients however, demonstrated a significantly greater proportion of sites (8.0%) with bone gain when compared to the placebo group (3.3%). There were no significant differences between the groups in the number of sites showing bone loss or no change. It is concluded that the 1% w/w flurbiprofen toothpaste exerts a small, yet significant effect on bone metabolism in the absence of any apparent effects on clinical parameters.
|
2022-11-23T18:04:07.319Z
|
22,481,533 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0300060513488499",
"MAG": "2164898712",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.1177/0300060513488499"
}
|
Objective To quantify faecal calprotectin concentrations in a variety of gastrointestinal disorders in order to determine its diagnostic value. Methods Patients with gastrointestinal symptoms undergoing upper or lower endoscopy and healthy control subjects provided stool samples. Calprotectin was quantified by enzyme-linked immunosorbent assay. Results The study recruited 210 patients with definitively diagnosed gastrointestinal diseases and 50 control subjects. Calprotectin concentrations were significantly higher in patients with ulcerative colitis or Crohn’s disease compared with controls, or patients with colorectal polyps or irritable bowel syndrome. The faecal calprotectin concentration significantly differentiated between inflammatory bowel diseases (IBD) and non-IBD (area under ROC curve 0.949). Calprotectin concentrations were significantly higher in patients with oesophageal polyps or gastric neoplasms than in those with chronic gastritis, stomach ulcers, duodenal ulcers or acute pancreatitis. Conclusion Calprotectin may be a useful noninvasive marker for the diagnosis of IBD.
|
2022-12-10T00:29:53.003Z
|
72,786,928 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/ARCHFAMI.2.10.1042",
"MAG": "2066766585",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
OBJECTIVE: To analyze weight maintenance, cost, and predictors of weight maintenance in a formula-based very-low-calorie diet program. DESIGN AND SETTING: Consecutive sample of patients evaluated at 30 months after program entry at a community hospital in Orange Park, Fla. PATIENTS: Consecutive sample of 306 patients who entered a very-low-calorie diet program. Of these, 255 met inclusion criteria. INTERVENTION: Patients entered a 26-week very-low-calorie diet program. At 30 months after program entry, questionnaires were mailed. Data were collected via telephone interview, as needed. MAIN OUTCOME MEASURES: Initial and maintained weight loss, and association of weight loss to the following factors: insurance coverage, continued exercising, weeks attended, exit weight in relation to ideal weight, and cost per kilogram of weight loss. RESULTS: Medically significant weight loss of 10% was initially achieved by 90% of patients and maintained by 33%. The average initial weight loss was 21.4 kg and the maintained weight loss was 6.5 kg for all patients. For those who remained in the program 19 weeks (61%), the initial weight loss was 25.6 kg and the maintained weight loss was 9.2 kg. Exercisers maintained more than twice as much weight loss as nonexercisers. Men lost a larger percentage of weight (22% vs 19%) and maintained more of that loss (29.5% vs 8.3%). Maintenance was not associated with insurance coverage and at how close patients came to achieving ideal weight. The cost was $396 per kilogram of weight loss maintained. An improved sense of well-being was expressed by 71% of patients. CONCLUSIONS: Very-low-calorie diet programs can be effective in maintaining a medically significant weight loss in some patients at 30 months after program entry. Longer attendance and regular exercise help weight maintenance. The high costs and rate of weight regain indicate the need to find a more affordable and effective strategy for weight loss and maintenance.
|
2022-12-16T14:10:53.838Z
|
183,371,842 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/S-0036-1576799",
"MAG": "2334010990",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Mit der Verleihung des Gutesiegels „Energie sparendes Krankenhaus“ an drei Einrichtungen in Berlin hat die Zahl der Krankenhauser mit okologischem „Leuchtturmcharakter“ einen neuen Hochststand erreicht.
|
2022-01-24T19:03:58.671Z
|
98,360,616 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/156856194X00186",
"MAG": "2050923869",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Bonding of chromium to the polyimide, PMDA-ODA, surface is still the subject of debate. In an attempt to clarify this problem, we have performed density functional theory calculations on different model molecules, phthalimide, PMDA, and PAP (p-amino phenol), which represent the most functionalities of the polyimide (PMDA-ODA). If we consider only the low spin case, we find that chromium bonds preferentially to the phenyl ring. However, when we release the spin constraint and optimize the structure, we find that the absolute stable configuration is that of chromium in a quintet state, at a carbonyl group. The energy difference is 0.30 eV. The complete infrared spectrum has been calculated for phthalimide and compared with experimental spectra. The agreement is excellent. A vibrational analysis for the Cr/phthalimide system, in both configurations (Cr on C=O and Cr on phenyl), in their stable spin states, is presented. We find that the former yields better agreement with experiment than the latter.
|
2022-02-10T12:34:43.397Z
|
73,205,675 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/009286150904300414",
"MAG": "2116981274",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The ultimate question to be answered in a clinical trial is “What benefit/risk has the drug caused to the patient?” To answer this question, it is critical to avoid missing data on outcome that measures benefit and risk from the beginning. This article emphasizes that when a patient discontinues the study treatment, instead of trying to impute the missing outcome values, effort should be made to follow the patient until the endpoint or the end of the trial. The information in the follow-up period can be used to describe the benefit/risk to those patients who would discontinue treatment in the actual clinical practice, while imputing values that are not observed, yet may never exist, can only answer the unrealistic question,“ What would have happened had the subject not discontinued?” Minimizing missing data is possible through the joint efforts of drug companies and regulatory agencies. Drug companies can improve their efforts in study design and operation, including off-treatment follow-up, prioritization of information collection, endpoint selection, and detailed documentation of reasons for missing data. Regulatory agencies can provide general guidance and convey specific comments for improvement through protocol review regarding missing data, and can ensure proper labeling language that reflects the extent of missing data and the reliability of conclusions.
|
2022-09-02T04:44:20.413Z
|
187,783,313 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33433/MARUHAD.503459",
"MAG": "2906963992",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Dunya Saglik Orgutu bunyesinde kabul edilen Tutun Kontrolu Cerceve Sozlesmesi sonrasinda basta Avustralya olmak uzere, bircok ulke tarafindan tutun urunlerinin duz paketlenmesine yonelik duzenlemeler kabul edilmistir. Duz paket duzenlemeleri ile tum tutun mamullerinin ilgili otorite tarafindan belirlenecek standart bir renkte paketlenmesi zorunlu kilinmaktadir. Ayrica, paket uzerinde marka ve urun adinin ilgili otorite tarafindan belirlenecek belli bir yazi tipi stili ve boyutunda yer almasi disinda logolarinin, marka tasvirlerinin, renklerin ve tanitim metinlerinin tutun urunleri ve perakende paketleri uzerine konulmasi yasaklanmaktadir. Tutun firmalarinca uygulamanin basta fikri mulkiyet haklari olmak uzere ulusal ve uluslararasi duzeyde ticaret ve yatirim kurallarini ihlal ettigi ileri surulmus ve duz paket uygulamasina gecen ulkelere karsi dava surecleri baslatilmistir. Soz konusu davalarin onemli bir kismi tamamlanmis olmakla birlikte, halen suren davalar da bulunmaktadir. Bu davalar ile ileride acilmasi muhtemel davalarin sonuclari, duz paket uygulamasinin dunya capinda gelecegini belirleyecektir.
|
2022-09-02T06:50:31.499Z
|
35,798,193 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00325481.1975.11713964",
"MAG": "2404311067",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The concept of brain death has become important in law and medicine, replacing in some instances the concept of circulatory arrest as a definition of death. Yet, brain death has not been established as a clear clinical or pathologic entity, a point brought out here by comparison of criteria for identification. The need for more research is evident.
|
2022-09-12T13:19:20.259Z
|
94,885,128 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.2069093",
"MAG": "2030305352",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Molecular dynamics (MD) simulation provides a quantitative method for screening efficient optical clearing agents. Some excellent optical clearing agents were obtained through the MD simulation of alcohols with hydroxyl groups. Among of the agents, fructose, one of polyols has the better efficacy which is one of monoaccharides. In comparison, disaccharides received little attention. In this study, sucrose and maltose were screened from common disaccharides for comparing with fructose. Actually, each agent has different saturation concentration. Here, the combination of molecular dynamic simulation and in vitro experiment was employed in this study. Firstly, the hydrogen bonds were used to predict the optical clearing potential of sucrose, maltose and fructose by using molecular dynamic simulation, respectively. The simulated results indicated that the optical clearing potential in a descending order as: sucrose, maltose and fructose. The reduced scattering coefficient of in vitro rat skin samples was used to evaluate the skin optical clearing potential based on measurements of reflectance and transmittance using a commercial spectrophotometer with an integrating sphere. Both the experimental and simulated results show that for the same concentration, disaccharides have better optical clearing potential than fructose. However, maltose has too low saturation concentration to produce similar optical clearing efficacy as the other two. By contrast, sucrose is the best one even though it has lower saturation concentrations than fructose.
|
2022-12-10T12:14:01.237Z
|
10,283,738 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/AEM.68.7.3251-3260.2002",
"MAG": "2086115755",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT The nucleotide sequence encoding the crystalline bacterial cell surface (S-layer) protein SbpA of Bacillus sphaericus CCM 2177 was determined by a PCR-based technique using four overlapping fragments. The entire sbpA sequence indicated one open reading frame of 3,804 bp encoding a protein of 1,268 amino acids with a theoretical molecular mass of 132,062 Da and a calculated isoelectric point of 4.69. The N-terminal part of SbpA, which is involved in anchoring the S-layer subunits via a distinct type of secondary cell wall polymer to the rigid cell wall layer, comprises three S-layer-homologous motifs. For screening of amino acid positions located on the outer surface of the square S-layer lattice, the sequence encoding Strep-tag I, showing affinity to streptavidin, was linked to the 5′ end of the sequence encoding the recombinant S-layer protein (rSbpA) or a C-terminally truncated form (rSbpA31-1068). The deletion of 200 C-terminal amino acids did not interfere with the self-assembly properties of the S-layer protein but significantly increased the accessibility of Strep-tag I. Thus, the sequence encoding the major birch pollen allergen (Bet v1) was fused via a short linker to the sequence encoding the C-terminally truncated form rSpbA31-1068. Labeling of the square S-layer lattice formed by recrystallization of rSbpA31-1068/Bet v1 on peptidoglycan-containing sacculi with a Bet v1-specific monoclonal mouse antibody demonstrated the functionality of the fused protein sequence and its location on the outer surface of the S-layer lattice. The specific interactions between the N-terminal part of SbpA and the secondary cell wall polymer will be exploited for an oriented binding of the S-layer fusion protein on solid supports to generate regularly structured functional protein lattices.
|
2022-12-23T02:26:11.803Z
|
108,574,499 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1742-6596/43/1/332",
"MAG": "2003908839",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/43/1/332"
}
|
We propose HTS microstrip disk resonator with an upper dielectric layer as a candidate resonator structure of HTS compact power filter for 4GHz band. The electromagnetic simulations on the upper dielectric layer examined the current distributions of the HTS resonators that had TM11 mode resonance of about 4 GHz. By the simulations, it is evaluated that of the maximum current density near the end portion of the disk-shape pattern of the resonator with the thick upper-layered structure decreases by roughly 30-50 percent, as compared with that of the resonator without it. Then, we designed and fabricated the resonator samples with and without the upper dielectrics. The RF power measurement results indicated that the upper dielectric layer leads to an increase in handling power.
|
2022-12-30T01:11:50.773Z
|
116,040,638 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/s-0032-1330162",
"MAG": "2625128619",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Die neue Leitlinie „Herzinsuffizienz“ gilt seit dem 19.5.2012 und ersetzt die Leitlinie von 2008. Sie ist herausgegeben von der Europaischen Gesellschaft fur Kardiologie und ubernommen von der Deutschen Gesellschaft fur Kardiologie. Zusatzlich berucksichtigt wurden 19 randomisierte kontrollierte Studien zur Herzinsuffizienz. Durch die Aktualisierung ergeben sich einige entscheidende Anderungen fur die Therapie.
|
2022-02-10T00:20:15.314Z
|
138,773,495 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1179/1432891715Z.0000000001632",
"MAG": "2175463909",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Recently, the CEB-FIP Model Code 2010 (MC10) provided a fibre-reinforced concrete tension model by which to evaluate the tensile behaviour of fibre-reinforced concrete, so that the tensile contribution achieved by fibres can be acknowledged in the design of concrete structures. In this model, the tensile behaviour of fibre-reinforced concrete is evaluated using a bending test of fibre-reinforced concrete beams with a notch, but there are still some deficiencies. For example, the effect of fibre type on the tensile behaviour is not considered. In this paper, therefore, the fibre-reinforced concrete tension model in MC10 has been re-evaluated, focused on the effect of fibre type. From the tensile behaviour of fibre-reinforced concrete predicted by the simplified diverse embedment model, fibre-reinforced concrete beams were analysed to derive the tensile behaviour of fibre-reinforced concrete by following the procedure presented in MC10. From comparison of the predictions with test results, it was determined that MC10 underestimates the tensile stress due to end-hooked fibres; while it overestimated the tensile stress due to straight fibres, when crack width was relatively small. Therefore, it can be concluded that the fibre-reinforced concrete tension model in MC10 can be improved by considering the effect of fibre type.
|
2022-05-31T16:32:42.371Z
|
144,963,166 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/13556509.2009.10799273",
"MAG": "2052807873",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract This essay proposes to explore the historical movement of text from scribal media to print publication as a translation process in which the printed text is viewed, not as an entirely new cultural product but one that has enjoyed previous lives. The essay first undertakes a revision of the dominant discourses on print in the Middle East, which have generally offered a salvation narrative fraught with Orientalist assumptions connected to the ‘sacredness’ of Arabic and the status of the Qur’an in Islamicate cultures. Likewise, the essay interrogates the historiography of print culture in Europe, which has exaggerated the impact of print and utilized it to create a divided and unequal temporality and geography between Europe and its others. The essay then offers a tentative attempt at a new cultural history which looks at continuities rather than ruptures in genres and practices before and after print, and in which the printing press plays the role of the habilitated and domesticated mediator/translator. To illustrate this, the essay takes the case of the modern Arabic newspaper and resituates it as a direct descendent of the early-modern scribal chronicle rather than as an entirely new innovation of the print age.
|
2022-09-12T10:43:56.558Z
|
198,735,521 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/1413-82712019240210",
"MAG": "2953668431",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://www.scielo.br/pdf/pusf/v24n2/2175-3563-pusf-24-02-337.pdf"
}
|
Abstract Emotion regulation is a multiprocessual phenomenon capable of maintaining, intensifying or diminishing the emotional experience. This work investigated the psychometric properties of the Emotion Regulation Inventory for Learning Situations, using the Item Response Theory (IRT). Participants included 365 students from the 5th to the 9th grades of elementary school, with a mean age of 11.9 years (SD = 1.72), 57.5% female and 42.5% male. The results indicated problems in the instrument, such as small variability of the items and underutilized categories of response, and ways for the revision of the instrument, such as construction of more difficult items that require internal strategies, focused on the learning experience.
|
2022-11-11T08:11:49.977Z
|
37,475,555 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1161/01.RES.0000214353.38360.A2",
"MAG": "2110022151",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
See related article, pages 524–531
Acute coronary syndromes, most often characterized by fissuring or rupture of coronary lesions, are responsible for the majority of clinical manifestations of atherosclerosis.1–3 Studies of human atherosclerotic plaques after acute events have revealed that lesions that tend to rupture are rich in inflammatory cells and have a thin fibrous cap, implicating the inflammatory response as a key regulator of plaque stability.3–5 Activated inflammatory cells within lesions, particularly activated macrophages, have been considered to be prime candidates for regulating plaque stability by releasing matrix-degrading enzymes and apoptosis-inducing factors. Although CD4+ T cells are a recognized component of vulnerable plaques,5 studies have primarily focused on activities of their associated Th1 cytokines that cause activation of macrophages and other vascular cells.6 However, analysis of CD4+ T cells from patients with acute coronary syndrome have shown these T cells acquire unique properties including antigen-independent cytolytic capabilities that can kill endothelial cells and smooth muscle cells in vivo.7–9 In this issue of Circulation Research , trafficking of these CD4 T effector cells into lesions is also shown to be independent of antigen stimulation,10 thus rendering them dangerous as they elude normal tolerance control.
Immune surveillance involves constant recirculation of lymphocytes through tissues. Naive T cells traffic from the blood into the secondary lymphoid organs and then back into the blood via the afferent lymph, a cycle that continues until such time that they recognize antigens for which their T cell receptors are specific. Once activated, the T cells proliferate, generating short-lived effector cells that can migrate to B cell areas or to inflamed tissues. When antigen challenge recedes, a fraction of the primed cells will persist as circulating memory cells, a state that on secondary antigen stimulation allows them to again …
|
2022-12-17T08:45:02.379Z
|
53,315,227 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1046/j.1365-2745.2001.00676.x",
"MAG": "2143882955",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
1 Vegetation change induced by large herbivores is driven by the effects of grazers on populations of individual plant species. Short‐term experimental or demographic studies may be insufficient when investigating the population responses of long‐lived clonal plant species.
|
2022-12-28T18:37:53.329Z
|
4,518,585 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/epi.14057",
"MAG": "2794530037",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/epi.14057"
}
|
Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy syndromes in the world. Depression is an important comorbidity of epilepsy, which has been reported in patients with TLE and in different experimental models of epilepsy. However, there is no established consensus on which brain regions are associated with the manifestation of depression in epilepsy. Here, we investigated the alterations in cerebral glucose metabolism and the metabolic network in the pilocarpine‐induced rat model of epilepsy and correlated it with depressive behavior during the chronic phase of epilepsy.
|
2022-12-30T00:23:49.233Z
|
245,102,517 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.20318/cian.2021.6441",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://e-revistas.uc3m.es/index.php/CIAN/article/download/6441/5078"
}
|
<jats:p>-</jats:p>
|
2022-01-27T03:44:41.425Z
|
149,059,133 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4312/AS.2018.6.1.73-109",
"MAG": "2786081371",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The reign of Abū al-Fath Jalāl al-Dīn Muhammad Akbar (1556–1605) was a fruitful period of the political, cultural and spiritual synthesis of Persian, Indian, and European tradition, as well as an artistic and aesthetic renaissance. This cosmopolitan, universal and charismatic ruler strived for the external, political, material and spiritual well-being of his colourful empire. In search of a balance between the external and internal, and in his endeavours for the unification and uniformity of India he gradually created a completely new style of Mughal arts, which is a stunning reflection of his personality’s transformations, principles, insights, interests, and spiritual growth. The paper focuses on a psychological portrait of the ruler, who dictated aesthetics and the style of the classical period of Mughal arts which consists of the three basic developmental phases of Akbar’s enigmatic character. The thesis on the parallel development of Akbar’s personality and Mughal arts is supported by research on the influence of certain European and Persian aesthetic elements, and mainly on the influence of Indian philosophical-religious tradition (the doctrines on rasa, bhakti, yoga, and tantra). The early period of Mughal arts, with predominantly realistic elements, coincides with the ruler’s dynamic, youthful enthusiasm and immense curiosity to acquaint himself the most varied aspects of external events and appearances. The second, the mature period, which enriches this earlier realism by means of mystical elements and the symbolism of Indian pre-Mughal painting, is marked by the shift into the interior and by searching for the harmony between the material and spiritual. In the late period of Mughal painting, however, reflexive and lyrical works prevail, which are a reflection of completion of Akbar’s spiritual quests, and the unique project of multifaceted synthesis that he undertook and promoted.
|
2022-02-09T04:33:42.400Z
|
107,353,950 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21236/ada297988",
"MAG": "164051420",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Abstract : Operational lessons learned from the Gallipoli Campaign that are applicable to modern day joint littoral operations are analyzed. Lessons learned from the failure of the Gallipoli Campaign are particularly significant for operational commanders today given the Navy's current emphasis on joint littoral operations. The Gallipoli Campaign offered the opportunity for Allied leaders in World War I to break the deadly stalemate on the Western Front and to open up critical lines of communication between the Western Allies and Russia. Poor planning, a lack of guidance, the failure to communicate clearly the concept of operations, along with poor on scene assessment and follow up were key factors that converged to destroy operational synchronization. This is best illustrated by the events on Y Beach and Suvla Bay, both of which were pivotal junction points in the Gallipoli Campaign. The failure of operational synchronization at these key points marked the failure of the Gallipoli Campaign and a lost opportunity to end the war early. The decisive role that operational synchronization plays in the ultimate success of joint littoral operations and the factors that lead to it are as vald today as they were in 1915. (MM)
|
2022-02-10T07:49:54.995Z
|
10,518,536 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SACI.2013.6608986",
"MAG": "1990034883",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper we introduce an unsupervised learning algorithm for discovering some of the conditional independences between the attributes (features) which characterize the elements of a statistical population. Using this algorithm we obtain a graph structure which makes possible the clustering of data elements into classes in an efficient way. In the same time our algorithm gives a new method for reducing the dimension of the feature space. In this way also the visualization of the clusters becomes possible in lower dimensional cases. The results of this type of clustering can be used also for classification of new data elements. We show how the method works on real problems and compare our results to those of other algorithms which are applied to the same dataset.
|
2022-02-13T06:09:34.619Z
|
28,800,652 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2174/1874471011205010038",
"MAG": "2107252164",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
2'-Deoxy-2'-fluorothymidine (FT) is a bioisostere of both thymidine (TdR), in which F replaces H at C-2' in the ribosyl configuration, and methyluridine, in which F replaces OH at C-2' in the ribosyl configuration. Fluorine is bioisosteric with H with respect to atomic radius and is bioisosteric with OH with respect to polarity and H-bonding as an H acceptor. The consequences of this C-2' F for H substitution on cytotoxicity, nucleoside transporter affinity, phosphorylation by thymidine kinases (TK1, TK2), cell uptake and biodistribution of FT in a murine tumor model are now reported. FT toxicity against a bank of murine and human cells was seen only at very high (˜1 mM) concentrations, although the cellular uptake of [3H]FT in these cells was comparable to that of [3H]TdR over a 24 h period. Human equilibrative nucleoside transporters (hENT1, hENT2) displayed weaker affinity for FT than for TdR, but the concentrative transporters (hCNT1, hCNT2, hCNT3) had much higher affinities for FT. FT was phosphorylated by both mitochondrial thymidine kinase (TK2) (58 % of TdR) and cytosolic thymidine kinase (TK1) (39 % of TdR). Preliminary in vivo imaging with [18F]FT in mice bearing implanted KBALB and contralateral KBALB-STK tumors showed highly selective uptake, with a tumor:blood ratio of 33 in a small herpes simplex type 1 (HSV-1 TK) expressing tumor. In conclusion, [18F]FT appears to be a strong candidate for PET imaging of viral TK transgene imaging, based on its TK1:TK2 phosphorylation differential, its selective uptake by an HSV-TK expressing murine tumor model, its interaction with nucleoside transporters and its low toxicity.
|
2022-02-12T14:05:45.374Z
|
137,174,392 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3365/MET.MAT.2008.04.233",
"MAG": "1998409953",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Magnetic and dielectric loss are systematically controlled by using iron flake powders with various initial sizes (7 μm and 70 μm) as the absorbent fillers in the rubber matrix, and their noise absorbing characteristics have been investigated as a function of frequency and sheet thickness. Flake iron particles were prepared by the mechanical forging of spherical powders using an attrition mill. Composite sheets (thickness=0.2 mm-1.0 mm) were prepared with a mixture of iron particles and silicone rubber. Attaching the composite sheets to a microstrip line of 50 Ω, a network analyzer was used to measure the reflection and transmission parameters (S11 and S21, respectively). A nearly constant value of S11 (about −10 dB) was observed, irrespective of particle size. However, S21 is strongly dependent upon initial particle size. For the composites of 7 μm particles (with high magnetic loss), S21 is reduced below −20 dB in the frequency range of 1 GHz to 10 GHz, and the corresponding bandwidth of noise absorption is not so greatly diminished by reducing the sheet thickness as low as 0.2 mm. For the composites of 70 μm particles (with high dielectric loss), however, the bandwidth is greatly reduced with a decrease in sheet thickness. It is concluded that the attenuation of conduction noise through the microstrip line is primarily controlled by the magnetic loss of the iron particles due to strong magnetic field around the microstrip line.
|
2022-02-09T10:48:00.784Z
|
155,994,129 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/SSRN.1283181",
"MAG": "2211352482",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The common perception is that while China has passed laws that are generally consistent with international standards, implementation is a serious problem. There is no doubt some truth to this view, more so in some areas than others. The purpose of this chapter, however, is to critically scrutinize this common perception. I will suggest, first, we know less about implementation than we think - in particular, we know very little about how implementation in China compares to implementation in other countries at China's level of development. Second, how rigorously laws should be enforced - and in some cases whether they should be enforced at all - is often contested, sometimes for good reasons. Third, even when there should be more rigorous implementation, it is often not clear what can or should be done to ensure it. Fourth, and related, theories about implementation in China are underdeveloped and conflicting, in part because theories about how to regulate a developing country as large as China are underdeveloped and conflicting.
|
2022-08-17T19:17:07.753Z
|
23,457,581 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISGTEurope.2016.7856234",
"MAG": "2587899869",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper shows the application of a multi-criteria analysis method for prioritization of commercial and supply restoration services in an electricity distribution company. The methodology is based on the Macbeth algorithm and on a large amount of input parameters that are evaluated in order to set the relative importance of each service. This study is of great relevance and complexity because it dynamically optimizes the use of the potential capacity of the available crew, increasing their efficiency and enabling the Company to be prepared to unpredictable situations. A computer program was developed to apply this method and the results were considered better than the ones from the current methods used by the Company and from other methods available on the literature. Also, it is suitable for real time daily applications.
|
2022-09-08T23:02:11.126Z
|
70,398,338 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmj.2.5596.52-b",
"MAG": "1968364472",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://europepmc.org/articles/pmc1985503?pdf=render"
}
|
SIR,-It is estimated that no fewer than 800,000 women in this kingdom are taking oral contraceptives, so if 80 women develop alopecia areata (9 March, p. 593) this amounts to no more than the normal incidence of 1 in 10,000. The suggestion of a causal relationship between alopecia and oral contraceptives was raised in your columns in 1965.l-3 After this I asked doctors working in the clinics of the Family Planning Association to tell me of any cases of alopecia which came to their notice. Ten cases were reported. During 1965 oral contraceptives were prescribed for 75,093 women at F.P.A. clinics. Assuming that the women had alopecia areata, and that all cases were reported, then the incidence was 10/75,093, which is closely similar to the incidence in the general population. One woman had had alopecia before starting the pill, three developed alopecia as soon as they started, and in the remainder the hair loss was noted between 3 and 21 months after starting an oral contraceptive. The pills prescribed contained the progestogens norethynodrel, norethisterone acetate, ethynodiol diacetate, and megestrol acetate. One doctor wrote to say that she had suffered from alopecia areata all her life but since taking the pill she had had no further trouble.I am, etc., HILARY HILL, Medical Secretary, Family Planning Association l ondon W. 1.
|
2022-09-09T01:53:03.618Z
|
1,035,905 |
{
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"ArXiv": null,
"DOI": "10.1021/acs.jpclett.6b01500",
"MAG": "2505481896",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://elib.dlr.de/105931/1/Saveleva%20et%20al_revised_final%20version.pdf"
}
|
Proton exchange membrane (PEM) electrolyzers are attracting an increasing attention as a promising technology for the renewable electricity storage. In this work, near ambient pressure X-ray photoelectron spectroscopy (NAP-XPS) is applied for in situ monitoring of the surface state of membrane electrode assemblies with RuO2 and bimetallic Ir0.7Ru0.3O2 anodes during water splitting. We demonstrate that Ir protects Ru from the formation of an unstable hydrous Ru(IV) oxide thereby rendering bimetallic Ru-Ir oxide electrodes with higher corrosion resistance. We further show that the water splitting occurs through a surface Ru(VIII) intermediate, and, contrary to common opinion, the presence of Ir does not hinder its formation.
|
2022-12-20T14:03:36.502Z
|
15,287,296 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/NAFIPS.2010.5548413",
"MAG": "2154626187",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, the fuzzy flood fill mean shift algorithm is introduced. This algorithm is developed for the methodology of robust segmentation by improving the mean shift algorithm through the fuzzy kernels and the flood fill technique, instead of those based on the spatial bandwidth. Due to this exchange, the flood fill mean shift involves only one parameter, the range bandwidth, which is less sensitive and is able to acquire the global characteristics. If the image parts affected by the illumination changes are sufficiently small and their boundaries are not clear, the illumination effects do not have an influence on the mode seeking procedure of the proposed fuzzy flood fill mean shift. To prove the usefulness and the validity of our algorithm, we present several experiments and analysis of the results.
|
2023-01-01T16:39:49.776Z
|
67,899,599 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.29007/sgqk",
"MAG": "2910486230",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://easychair.org/publications/open/kR9"
}
|
DC and AC bridges have been used in abundance for a long period of time for the component measurements as well as other parameters measurements. AC bridges are principally used for the determinations of component values and the associated parameters namely the self-inductance, mutual inductance, capacitance etc. In this paper the authors have presented a novel method using latest computing and analysis tools to investigate the capacitor ageing of a popular capacitor used in day to day life using a nonconventional AC bridge like circuit. Keywords—Unknown capacitors, AC bridges, DC bridges, Detector, Capacitor ageing
|
2022-02-11T12:36:23.007Z
|
150,706,368 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.46743/2160-3715/2019.3014",
"MAG": "2912489896",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://nsuworks.nova.edu/cgi/viewcontent.cgi?article=3014&context=tqr"
}
|
The heart and soul of ethnography lies in anthropological study within specific caste, ethnicity, and gender. In mass media research, the anthropological ethnography dominates through some of the aspects that focuses on geographical locations and ethnicity which is not relevant in the age of media and technology. The mass media has gained its own gravity, uniqueness, and distinctiveness at present as it fulfills the need and interest of individuals/society. As such fieldwork, participants, and positioning a debate within the realm of “anthropological ethnography” is not sufficient to understand the subjectivities of mass media. In such a context, this article analyzes and presents field, fieldwork strategies, participants’ and researchers’ roles that demands wideness in mass media research.
|
2022-04-08T00:21:11.881Z
|
218,636,242 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1080/14634980008656986",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Large lakes, or inland seas, of >500 km 2 in surface area make up 93% and 88% of the total surface and volume, respectively, of fresh water reserves in the world. Although these large ecosystems differ from one another in various aspects, they do possess some similar physical, chemical and biological char acteristics. Many large lakes have similar thermal regimes, thermal bar formations, and experience upwelling. In addition, many have large mean depths, deep mixing, long residence times, inshore-offshore gradients and greater exposure to long range transport of contaminants due to their immense size (Herdendorf, 1982; Beeton, 1984; Munawar, 1987). Although a considerable number of papers have been published on large lakes, comparisons of their ecology, structure and function are few. This special issue is designed to focus on these comparative aspects so that the obvious gaps may be bridged. This Large Lakes Ecology issue is a collection of papers most of which originated from an International Symposium "Exploring the Great Lakes of the World (GLOW): Food-web Dynamics, Health and Integrity". The GLOW symposium was sponsored by the Aquatic Ecosystem Health and Management Society (AEHMS) in collaboration with the South African Society of Aquatic Scientists (SASAS) at Victoria Falls, Zimbabwe in the summer of 1996. The paper dealing with exotic species was invited later because of the importance of biological invasions in aquatic ecosystems. A compendium of papers (edited by M. Munawar and R. Hecky, 2000) which focuses on the Great Lakes of the World is in press and will appear elsewhere in a peer reviewed book. This issue provides a variety of interesting assessments of various ecological parameters. For example, extensive comparisons of many large lakes are presented for phytoplankton population dynamics by Reynolds et al. and for exotic species by Hall and Mills. Other lake-wide comparisons include temperate Lake Superior versus tropical Lake Malawi (Hecky; Guildford et al.), lakes of Northern Canada (Evans) and Chinese lakes (Dokulil et al.). The remaining papers provide details of wind driven circulation in Lake Tanganyka (Podsetchine and Huttula) and a 6000 year record of interactions between Lake Ontario and its connection to Hamilton harbour. It is hoped that this special publication will be useful to a wide variety of researchers in both temperate and tropical regions, enhance our understanding of the functioning of large lakes and result in the conservation of these large ecosystems in the future. The assistance of the symposium and editorial committees is sincerely acknowledged for the convening of the symposium and the development of this special issue, respectively:
|
2022-07-11T02:14:05.074Z
|
154,806,486 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0018246X00010979",
"MAG": "2113818658",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article is a byproduct of a large-scale research project on the politics of Salford since 1830. In a sense, it shows what can happen to an historian when working amongst political scientists, for the article attempts to apply a few of the latter's concerns, and ways of looking at the world, to a specific historical situation. Though the raw material for the article is almostentirely historical, I hope that its themes will be of interest to people in both disciplines.
|
2022-09-06T18:10:04.048Z
|
17,488,991 |
{
"externalids": {
"ACL": null,
"ArXiv": "1204.3994",
"DOI": "10.1145/2023607.2023711",
"MAG": "2952248138",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1204.3994"
}
|
We continue the study of a new family of multivariate wavelets which are obtained by "polyharmonic subdivision". We provide the results of experiments considering the distribution of the wavelet coefficients for the Lena image and for astronomical images. The main purpose of this investigation is to find a clue for proper quantization algorithms.
|
2022-10-25T10:04:44.057Z
|
222,223,569 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.9734/AJOCS/2020/V8I319041",
"MAG": "3089313050",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Aims: Aim of our study was to analyze various nutritional fact of three types of grape fruits and compare their facts in terms of consumption. The grape is one of the most edible fruit with high amount of nutritional and medicinal properties. Study Design: Physico-chemical analysis by using various chemical analysis and instrumental methods for analysis of various grape samples. Place and Duration of Study: Department of Applied Sciences, Chemistry section, University of Technology and Applied Sciences, Muscat, Oman. The study was performed during the May 2018 – December 2018. Methodology: We have selected three different grapes samples from the local market for the analysis (Green grapes, Red grapes and Black grapes). Our research study includes testing of various physico-chemical parameters for nutritional fact of fruit, such as water, carbohydrates, proteins, fat, vitamin C, and different minerals. We analyzed various physic-chemical parameters. Original Research Article Patil et al.; AJOCS, 8(3): 1-8, 2020; Article no.AJOCS.61330 2 Results: We found that pH in the range of 3.775 – 4.14, conductivity 1.39 MS/cm – 1.553 MS/cm, titratable acidity was measured in terms of tartaric acid was found 0.712 g/100ml 1.065 g/100ml and Brix% value 9.5% 15.5%. Amount of water in berry was 77.964 % – 80.146 %, Ash in the range of 0.72 – 3.911 %. Protein 6.245 g/100ml – 7.928 g/100ml, Fiber content 1.112 % – 1.143% and good amount of potassium, magnesium, calcium, iron and zinc. Conclusion: Analysis of three types of grapes we found, acidity of green grapes was highest. It might be depending upon ripening stage of berry. That are correlated to sugar ( 0 Brix). Fiber value was very close to each other. Iron was highest in red grapes and then green grapes. Potassium, magnesium, calcium and zinc was found to higher in green grapes. Based on this green grape looks batter nutritional value.
|
2022-10-28T00:20:10.760Z
|
247,946,559 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/info13040182",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2078-2489/13/4/182/pdf?version=1648884355"
}
|
In this work a multicriteria optimization approach to minimize weight and maximize power output in piezoelectric energy harvesting systems for aerospace applications is studied. The design variables are the geometric and electric circuit parameters of the vibration-based piezoelectric energy harvester (PEH). A finite element model is developed to model the dynamic behavior of the composite plate-type harvester with embedded piezoelectric layers. The cantilever PEH structure is subjected to constraints in the bending stresses which must be lower than or equal to the tensile yield strength of the piezoelectric material. For solving the multi-objective optimization problem, the Non-dominated Sorting Genetic Algorithm II (NSGA-II), the Non-dominated Sorting Genetic Algorithm III (NSGA-III) and the Generalized Differential Evolution 3 (GDE3) algorithm are employed. It is shown that the proposed algorithms are effective in developing optimal Pareto front curves for maximum electrical power output and minimum mass of the PEH system. A comparative assessment of the solutions generated on the Pareto Front show that GDE3 achieved solutions that generate higher maximum power output and performs better compared to the two other algorithms.
|
2022-12-05T16:30:58.489Z
|
56,000,078 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/APP.12503",
"MAG": "2135094818",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Grafting of vinyl monomers onto isotactic polypropylene (iPP) in the solid state, that is, below the melting point, displays several advantages over melt or solution grafting processes, such as negligible degradation of the iPP and absence of any solvent. The final properties of such iPP modifications or actually compatibilized PP blends are dependent on the dispersion of the new polymer into the iPP matrix, which is controlled to a large extent by the degree of grafting versus the amount of free homopolymer formed. In the present work, the solid-state modification of iPP by styrene has been investigated from the point of view of the monomer polymerization behavior. In order to deter- mine the styrene conversion and the distribution of the newly formed PS phase along the radius of the iPP powder particles, the reaction products were characterized by infra- red (FTIR) and Raman spectroscopy. Fractionation of the reaction products via selective solvent extraction allowed the determination of the grafting efficiency (). It was shown that besides the grafted PS two additional types of PS are formed, that is, free PS homopolymer in the pores of the PP powder and free PS in the amorphous PP phase. Phi shows an optimum as a function of the feed peroxide com- position and the feeding rate. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 3279 -3291, 2003
|
2022-12-20T00:51:23.906Z
|
224,128,077 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.1001-9030.2018.10.044",
"MAG": "3031177911",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective
To study the expression level of methyltransferase 3 (METTL3) in the breast cancer, analyze the correlation between METTL3 and clinicopathological characteristics of breast cancer, and explore possible mechanisms of the involvement of METTL3 in the occurrence and development of breast cancer.
Methods
54 cases of breast carcinoma and para-carcinoma tissues were collected. Western blotting was used to detect the protein expression of METTL3 in breast carcinoma and adjacent tissues. Real-time fluorescent quantitative polymerase chain reaction (FQ-PCR) method was operated to detect the expression of METTL3 mRNA and the correlation between METTL3 and clinicopathological characteristics of breast cancer.
Results
The expression of METTL3 in breast cancer was significantly higher than in the adjacent tissues (P=0.001). The expression of METTL3 mRNA was not related to age, the size of tumor, status of estrogen receptor (ER), and progesterone receptor (PR) (χ2=1.856, P=0.173; χ2=0.351, P=0.554; χ2=0.037, P=0.847; χ2=2.598, P=0.107), but to lymph node metastasis, human epidermal growth factor receptor-2 (Her-2) and proliferation cell nuclear antigen (Ki-67) (χ2=4.913, P=0.027; χ2=7.517, P=0.006; χ2=10.165, P=0.001), Western blotting showed that the expression of METTL3 in breast cancer (4.691±0.373) was higher than in the normal tissue (2.238±0.362) (P=0.016).
Conclusion
The expression of METTL3 in breast cancer is higher than in normal tissues, and is correlated with lymph node metastasis, depth of invasion and TNM staging, suggesting their roles in the breast cancer.
Key words:
Methyltransferase 3; Breast cancer; Clinicopathological characteristics
|
2022-02-08T00:28:14.593Z
|
201,620,999 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/HPSR.2019.8808120",
"MAG": "2969647690",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The fifth generation of mobile communications (5G) is expected to dramatically improve performance compared to preceding standards by offering very high bandwidths and low latencies. To provide this performance, heavy processing is required and must meet strong timing constraints. Reconfigurable computing, managing processing in software and exploiting reconfigurable hardware acceleration, is an innovative approach that should be considered for 5G for its capacity to combine high throughput and high flexibility. This paper presents a case study for Orthogonal Frequency Division Multiplexing (OFDM) computation reconfigurable offloading onto an Field Programmable Gate Array (FPGA). The implementation is based on Open Computing Language (OpenCL) that represents a versatile solution, as this language can be compiled for several architectures, provided that a Host+Accelerator structure is used. The objective of our study is to demonstrate that, by means of hardware offloading, the 5G architecture resources can reach high computational load, avoiding processing stalls and latency increase. Results show that around 15% of the software processing can be freed through hardware acceleration and reallocated to support other tasks.
|
2022-02-08T05:06:30.404Z
|
149,205,657 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/S-0035-1558013",
"MAG": "2611470874",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Hypomanic personality (HYP) has been suggested as a risk-factor for bipolar affective disorder (BAD). Whereas tentative data on validity of HYP in predicting BAD are available, data on biological correlates are scarce. Therefore, we associated different biological traits, which can be expected to be linked to HYP: Candidate polymorphisms were selected based on their relevance for the monoaminergic and/or circadian system or due to their former association with BAD. Additionally, sleep was assessed given its pivotal role in BAD. Finally, sleepiness and brain arousal were assessed as it was recently suggested that alterations in brain arousal regulation contribute to the development of affective disorders. Methods: HYP and sleepiness were assessed by questionnaires, sleep by both questionnaire and actigraphy, and arousal regulation by resting EEG. Subjects were selected from the Leipzig Health Care Study (LIFE). The number of subjects differed with regard to the analyzed phenotypes and phenotype-specific exclusion criteria (ranging from about 800 to more than 2000). Results & Discussion: Healthy HYP high scorers showed sleep, sleepiness and arousal patterns, which are similar to those found in BAD and associated diagnostic groups, such as ADHD. Some candidate genes were also associated with HYP. These results are in line with the arousal regulation theory of affective disorders (Hegerl & Hensch, 2014) and further contribute to the validation of the HYP scale. This publication is supported by LIFE – Leipzig Research Center for Civilization Diseases, Universitat Leipzig. LIFE is funded by means of the European Union, by the European Regional Development Fund (ERDF) and by means of the Free State of Saxony within the framework of the excellence initiative.
|
2022-02-09T04:29:32.082Z
|
160,035,735 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4000/GC.656",
"MAG": "301943321",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Avec l’informatisation et la rapidite qu’elle assure aux relations interpersonnelles et a l’echange des informations dans le monde contemporain, les groupes de capoeira de Salvador sont en train de s’integrer peu a peu dans ce que l’on appelle « l’univers virtuel ». Dans ce contexte, ils rompent avec les comportements traditionnels et intensifient la communication entre les groupes a travers le reseau mondial des ordinateurs, essentiellement comme utilisateurs des sites de mise en relation (les reseaux sociaux), l’Orkut par exemple, qui rendent possible le raccourcissement des distances entre groupes et maitres. L’objectif principal de la recherche sur les “rapports entre capoeira et Internet : tactiques de territorialisation dans les quartiers populaires de Salvador, Bahia” a ete de comprendre les relations entre la capoeira et l’univers virtuel d’Internet a partir de l’analyse des tactiques de territorialisation des differents groupes et communautes dans les quartiers de Salvador. Les groupes de Capoeira dont les communautes sont actives sur Orkut ont ete reperes, leurs lieux d’implantation dans la ville determines, et les maitres et participants des groupes selectionnes ont ete interviewes. L’analyse des resultats obtenus souligne que l’appropriation des outils disponibles grâce a Orkut elargit les relations et raccourcit les distances entre les groupes et les maitres ; elle facilite aussi les ramifications entre divers lieux de la ville et du monde d’une maniere heterogene et plurielle.
|
2022-02-08T22:56:54.691Z
|
11,638,872 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1121/1.403772",
"MAG": "2018217947",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The first part of this paper presents several experiments on signal detection in temporally modulated noise, yielding a general approach toward the concept of comodulation masking release (CMR). Measurements were made on masked thresholds of both long- and short-duration, narrow-band signals presented in a 100% sinusoidally amplitude-modulated (SAM) noise masker (modulation frequency 32 Hz), as a function of masker bandwidth from 1/3 oct up to 13/3 octs, while the masker band was geometrically centered at signal frequency. With the short-duration signals placed in the valley of the masker, a substantial CMR (i.e., a decrease of masked threshold with increasing masker bandwidth) was found, whereas for the long-duration signals CMR was smaller. Furthermore, investigations were carried out to determine whether CMR changes when the bandwidth of the signals, consisting of bandpass impulse responses, is increased. The data indicate that substantial CMR remains even when all masker bands contain a signal component, thus minimizing across-channel differences. This finding is not in line with current models accounting for the CMR phenomenon. The second part of this paper concerns signal detection in spectrally shaped noise. Also investigated was whether release from masking occurs for the detection of a pure-tone signal at a valley or a peak of a simultaneously presented masking noise with a sinusoidally rippled power spectrum, when this masker was preceded and followed by a second noise (temporal flanking burst) with an identical spectral shape as the on-signal noise. Similar to CMR effects for temporal modulations, the data indicate that coshaping masking release (CSMR) occurs when the signal is placed in a valley of the spectral envelope of the masker, whereas no release from masking is found when the signal is placed at a peak of the spectral envelope of the masker. The implications of these experiments for measures of spectral and temporal resolution are discussed.
|
2022-08-09T18:35:04.235Z
|
2,125,356 |
{
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"ArXiv": null,
"DOI": "10.1109/CC.2015.7385529",
"MAG": "2240799721",
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},
"license": null,
"status": null,
"url": null
}
|
Equipped with millions of sensors and smart meters in smart gird, a reliable and resilient wireless communication technology is badly needed. Mobile networks are among the major energy communication networks which contribute to global energy consumption increase rapidly. As one of core technologies of smart grid employing mobile networks, Demand Response (DR) helps improving efficiency, reliability and security for electric power grid infrastructure. Security of DR events is one of the most important issues in DR. However, the security requirements of different DR events are dynamic for variousactual demands. To address this, an event-oriented dynamic security service mechanism is proposed for DR. Three kinds of security services including security access service, security communication service and security analysis service for DR event are composited dynamically by the fine-grained sub services. An experiment prototype of the network of State Grid Corporation of China (SGCC) is established. Experiment and evaluations shows the feasibility and effectiveness of the proposed scheme in smart grid employing mobile network.
|
2022-09-16T03:54:02.339Z
|
117,893,570 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.2722060",
"MAG": "1494912989",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Most of the underground experiments in physics and many studies in geology, biology or environmental sciences face a common requirement with the necessity of using experimental devices with ultra‐low background radioactivity. Many developments involving many different techniques have been used in order to be able to measure extremely low levels of radioactivity in materials. This report will focus on low background gamma‐ray spectrometry and will describe the work which has been carried out over the last fifteen years in the “Laboratoire Souterrain de Modane” (LSM).
|
2022-09-19T08:41:12.144Z
|
197,553,006 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1179/174328405X63953",
"MAG": "2069189351",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Phosphorus and molybdenum segregation to grain boundaries in a commercial grade A533B steel subjected to a variety of heat treatments has been examined using a field emission gun scanning transmission electron microscope (FEGSTEM) with energy dispersive X-ray micro-analysis. The results indicate that P and Mo concentrations at prior austenite grain boundaries increase with aging time. This follows the prediction of McLean's equilibrium segregation model, when modified to take account of the interaction energy between phosphorus and molybdenum.
|
2022-11-16T23:29:16.083Z
|
121,172,217 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVB.70.113304",
"MAG": "2320443492",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We have studied the electronic properties of the nanoclusters formed by In on the Si s100d surface by angle-resolved photoemission spectroscopy. The Si s100d433-In surface, composed of Si 7In6 nanoclusters, was found insulating with an energy gap of 0.5 eV below Fermi energy. The nanocluster array on this surface induces five different surface states with a characteristic and dominating one within the band gap. The doping of further In onto this surface yields no significant change of the band gap in contrast to the recent scanning tunnelling spectroscopy study reporting metallic cluster formation [Phys. Rev. Lett.,91, 026104 (2003)]. The experimental result is fully supported by first-principles calculations, which reveal both the In-doped sSi5In8d and undopedsSi7In6d nanoclusters are insulating with the energy gaps of 0.42 eV and 0.53 eV, respectively.
|
2022-12-12T18:18:20.031Z
|
28,786,557 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2017/2792131",
"MAG": "2770628625",
"PubMedCentral": "5735609"
},
"license": "CCBY",
"status": "GOLD",
"url": "http://downloads.hindawi.com/journals/bmri/2017/2792131.pdf"
}
|
Strategies to improve doctor-patient communication may have a beneficial impact on patient's illness experience and mood, with potential favorable clinical effects. We prospectively tested the psychometric and clinical validity of the Decalogue, a tool utilizing 10 communication recommendations for patients and physicians. The Decalogue was administered to 100 consecutive patients referred for a cardiologic consultation, whereas 49 patients served as controls. The POMS-2 questionnaire was used to measure the total mood disturbance at the end of the consultation. Structural equation modeling showed high internal consistency (Cronbach alpha 0.93), good test-retest reproducibility, and high validity of the psychometric construct (all > 0.80), suggesting a positive effect on patients' illness experience. The total mood disturbance was lower in the patients exposed to the Decalogue as compared to the controls (1.4 ± 12.1 versus 14.8 ± 27.6, p = 0.0010). In an additional questionnaire, patients in the Decalogue group showed a trend towards a better understanding of their state of health (p = 0.07). In a cardiologic ambulatory setting, the Decalogue shows good validity and reliability as a tool to improve patients' illness experience and could have a favorable impact on mood states. These effects might potentially improve patient engagement in care and adherence to therapy, as well as clinical outcome.
|
2022-12-16T12:38:26.920Z
|
9,160,647 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/eb-2017-102752",
"MAG": "2786660982",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://eprints.kingston.ac.uk/id/eprint/39854/1/Quinn-T-39854-AAM.pdf"
}
|
Commentary on : Fu S, Lv X, Fang Q, et al . Oxygen therapy for acute myocardial infarction: a systematic review and meta-analysis. Int J Nurs Stud 2017;74:8–14.
Oxygen therapy has been a mainstay of emergency management of patients with suspected AMI for decades. In recent years, systematic reviews have raised concerns that oxygen may be harmful to patients with AMI, but the quality of evidence has been low. …
|
2022-12-23T02:06:08.079Z
|
2,979,817 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/2554850.2554865",
"MAG": "2522325872",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://lirias.kuleuven.be/bitstream/123456789/457790/1/llfatr.pdf"
}
|
Many software systems adopt isolation mechanisms of modern processors as software security building blocks. Reasoning about these building blocks means reasoning about elaborate assembly code, which can be very complex due to the loose structure of the code. A way to overcome this complexity is giving the code a more structured semantics. This paper presents one such semantics, namely a fully abstract trace semantics, for an assembly language enhanced with protection mechanisms of modern processors. The trace semantics represents the behaviour of protected assembly code with simple abstractions, unburdened by low-level details, at the maximum degree of precision. Additionally, it captures the capabilities of attackers to protected software and simplifies providing a secure compiler targeting that language.
|
2022-12-23T02:07:22.575Z
|
84,450,738 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1365-2109.2008.02001.X",
"MAG": "2012395382",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Farming of yellowtail kingfish (Seriola lalandi, Valenciennes, 1833) in the coastal waters of Australia is a relatively new aquaculture industry, and little is known about the magnitude of nutrient discharges from individual pens. In this work, we modelled the flow of nitrogen for each of two commercial pens in Fitzgerald Bay, upper Spencer Gulf, South Australia. The fish were fed commercial pellets with feed conversion ratios (FCRs) between 3.0 and 3.2 (dry weight feed/wet weight growth). These high values of FCR were reflected in the high nitrogen loads to the environment (176-195 kg N tonne⁻¹ growth) and a small retention of nitrogen in fish growth (14-16% of feed inputs). Considering an annual production of 2000 tonnes, total loads to the environment can reach 391 tonnes N year⁻¹. Eighty-two per cent of these loads are expected to be lost to the water column as dissolved wastes. The high nutrient loads and the importance of dissolved wastes compared with other aquaculture species, such as salmon and trout, reflect the distinctly higher metabolic rates of this pelagic predatory species. The nature of the wastes suggests low localized impacts at current production levels, but regional effects remain unknown.
|
2022-12-30T01:18:52.203Z
|
230,573,679 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25281/0869-608x-2020-69-5-455-470",
"MAG": "3111962604",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://bibliotekovedenie.rsl.ru/jour/article/download/1992/1230"
}
|
In the year of the 75th anniversary of the Great Victory, the authors consider the activity of the V.I. Lenin State Library of the USSR (GBL) on preparation and release of bibliographic publications during the Great Patriotic War. This topic was covered in the specialized literature briefly and fragmentally (with the exception of work in the field of recommendation bibliography). The aim of the article is to fill in the existing gaps in the study of this area of GBL activity during the war.In the pre-war years, the GBL transformed into one of the leading bibliographic centres of the country — both reference and bibliographing. Both directions were mainly concentrated in the Scientific Bibliographic Department, where at the turn of the 1930s and 1940s preparation of bibliographic publications was structurally distinguished.With the beginning of the war, the GBL reorganized its work in accordance with the conditions and tasks of wartime. The amount of bibliographic work in the first months of the war was significantly reduced. Publishing activities, including the production of bibliographic publications, ceased and resumed in the second half of 1942. Recommendation indexes and lists on actual subjects were the main type of bibliographic materials created and published by the GBL during the war years.The article highlights the activities of two leading bibliographic departments of the GBL during this period: the Scientific Bibliographic Department and the Military Department. There are two areas of activity of the Scientific Bibliographic Department: general and scientific-auxiliary bibliography and recommendation bibliography. During the Great Patriotic War, the library produced mainly reference manuals, as well as also prepared several scientific publications. The authors present employees of both departments who have made the most significant contribution to the preparation of bibliographic publications. In addition, the article notes several bibliographic publications created in other structural divisions.
|
2022-01-27T20:02:11.785Z
|
81,785,164 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1096/fasebj.22.1_supplement.1197.13",
"MAG": "103675745",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
ES‐like stem cells from the human umbilical cord matrix (HUCM) express the ES transcription factors Oct‐4 and nanog. HUCM cells also express adult stem cell markers so appear to be intermediate between ES and tissue‐specific adult stem cells. HUCM cells can be differentiated into endodermal, mesodermal and ectodermal lineages making them candidates for cell‐based therapies. We explored changes in gene expression after differentiation of HUCM cells into different cell lineages. In particular, we determined changes in expression of genes associated with undifferentiated embryonic stems (Oct4 and nanog); adult stem cells (CD146, CD90 and smooth muscle actin) and immune complexes (HLA‐ABC and MHC II). We found that Oct4 and nanog expression was decreased to non‐detectable levels after differentiation of HUCM cells and that smooth muscle actin was initially greatly diminished, becoming disorganized and eventually below the level of detection. HLA‐ABC and MHC‐II are not detectable in undifferentiated HUCM cells or in some cases HLA‐ABC expression was very weak. Expression of MHC‐II remained below the level of detection and HLA‐ABC remained very low after in vitro differentiation. This work will establish whether HUCM cells are potential candidates for allogenic cell‐based therapies. Funded by NIH Grant Number P20 RR016475, NIH (R01NS036124) and the State of Kansas.
|
2022-06-18T14:54:57.255Z
|
12,221,824 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/02652030600599132",
"MAG": "1997200702",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A total of 634 samples of oranges, tangerines, peaches, nectarines, khakis and watermelons were collected from an Agricultural Valencia Community Cooperative during the May 2001 to April 2003 campaigns and they were analysed for 15 pesticides among those recommended for pest treatment. A conventional multiresidue analytical procedure based on ethyl acetate extraction was used followed by gas chromatography coupled to a nitrogen phosphorus detector for routine analysis; and mass spectrometry was performed for confirmation. Recovery studies with spiked samples at 0.5 mg kg−1 for each pesticide ranged from 52% for acephate to 87% for fenthion with a standard deviation <20%. Limits of quantification ranged from 0.1 to 100 µg kg−1. A total of 43% of samples contained pesticide residues; and 5% exceeded the maximum residue levels (MRLs). Nine of the pesticides studied were found. Malathion, which was the most frequently detected, was found in 121 samples (19%) at 0.002–4.25 mg kg−1; followed by fenthion in 104 samples (16%) at 0.005–2.3 mg kg−1; and methidation in 68 samples (10%) at 0.008–1.3 mg kg−1. Khaki showed the highest contamination rates with 60% of contaminated samples that exceeded more often the MRLs; and fenthion was the pesticide more frequently detected in all the commodities studied at levels above the European MRLs. The estimated daily intakes of each pesticide calculated from the results obtained were much lower than the acceptable daily intakes.
|
2022-10-02T16:43:22.023Z
|
250,373,091 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12737/jflcl.2021.070",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.12737/jflcl.2021.070"
}
|
. Recently, in the common economic space of the Eurasian Economic Union (EAEU), there has been a tendency to conduct international settlements on trade, investment and banking transactions in the national currencies of the EAEU member states. At the same time, the promissory note as an instrument of international settlements in the national currency is not yet widely used in the EAEU common financial market. The purpose of the article is to study the current problems of international promissory note settlements in the national currency within the EAEU and to find ways to improve legislation in this area. Objectives of the article: study of civil and bill legislation of the EAEU member states, international legal norms, analysis of judicial practice and doctrinal sources on these issues. Research methods: dialectical, system-structural and comparative-legal, interpretation of law, etc. The author examines the legal status of the promissory note, examines the features of international promissory note settlements in the national currency within the EAEU, analyzes the promissory note legislation of the EAEU member states in terms of replacing the foreign currency of debt with the national currency of payment, choosing the exchange rate, the procedure for paying the amount of the promissory note in the currency specified in it. Recommendations are presented on solving problems in this area by harmonizing the bill legislation of the EAEU member states and introducing a single form of bill forms. To improve the mechanism of international promissory note settlements in the national currency within the framework of the EAEU, it is proposed to create a special electronic accounting system —
|
2022-10-21T01:21:52.134Z
|
229,316,120 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/d0cp03866k",
"MAG": null,
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},
"license": null,
"status": null,
"url": null
}
|
Promotion in power conversion efficiency is an appealing task for quantum dot-sensitized solar cells that have emerged as promising materials for the utilization of clean and sustainable energy. Doping of Mn atoms into quantum dots (QD) has been proven to be one of the effective approaches, although the origin of such a promotion remains controversial. While several procedures are involved in the power conversion process, electron injection from the QD to the semiconductor oxide substrate is focused on in this work using first-principles calculations. Based on the Marcus theory, the electron injection rates are evaluated for the quantum dot-sensitized solar cell models in which the pure and Mn-doped core-shell CdSe clusters are deposited on a semiconductor titanium dioxide substrate. Enhanced rates are obtained for the Mn-doped structure, which is in qualitative agreement with the experiments. A large number of dominant injection channels and strong QD-substrate coupling are responsible for the Mn-induced rate enhancement, which could be achieved by manipulating the band structure mapping between the QD and the semiconductor oxide. By addressing the role of an Mn dopant in the electron injection process, strategies for the promotion of electron injection rates are proposed for the design of quantum dot-sensitized solar cells.
|
2022-12-15T03:56:31.098Z
|
206,105,791 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1748-6041/8/5/055002",
"MAG": "1965842172",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cell behavior can be manipulated by the topography of the culture surface. In this study, we examined the intercellular communication and osteogenic differentiation of mesenchymal stem cells (MSCs) grown on electrospun fibers with different orientations and densities. Human bone marrow-derived MSCs (hMSCs) were seeded on poly(ε-caprolactone) (PCL) electrospun scaffolds composed of aligned (1D) or cross-aligned (2D) fibers (1.0–1.2 µm diameter) with high, medium, or low fiber densities. It was found that cells preferred to adhere onto electrospun PCL fibers rather than on the flat substrate. The immunofluorescence staining showed that the expression of vinculin, a focal adhesion protein, was limited to the periphery and the two extremities of aligned cells on the edge of the fibers. Electron microscopy showed that cells extended their lamellipodia across the adjacent fibers and proliferated along the direction of fibers. Cells grown on 1D fibrous scaffolds at all fiber densities had an obvious alignment. On 2D fibers, a higher degree of cell alignment was observed at the higher fiber density. On 1D scaffolds, the gap junction intercellular communication (GJIC) quantified by the lucifer yellow dye transfer assay was significantly promoted in the aligned cells in the direction parallel to the fibers but was abolished in the direction perpendicular to the fibers. The expression of osteogenic marker genes (RUNX2, ALP, and OCN) was significantly enhanced in seven days by culture on 1D but not 2D fibers. It was thus proposed that the promoted osteogenic differentiation of hMSCs may be associated with the fiber-guided and directional induction of GJIC.
|
2022-12-18T00:23:28.845Z
|
144,446,312 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/JCOP.10043",
"MAG": "2070013930",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Our purpose is to enhance the field's understanding of the nature of community leadership, the psychological sense of community, and the spiritual dimensions of community life. We describe an action research community development project conducted in a low-income Catholic parish in Lagos, Nigeria, in Western Africa. After describing the community development process that resulted in the establishment of 40 small/street basic communities (SBCs), we report an evaluation study in which 70 SBC leaders were surveyed regarding (1) SBC background characteristics (socioeconomic and environmental conditions and statistical information), (2) the state of community life in the SBCs (spirit/sense of community, participation in activities, benefits of community life), and (3) challenges for the future (what SBC members and leaders can do to improve the community, problems influencing community development). We then reflect on the Lagos findings in light of leadership-for-community and spirituality frameworks developed in an action research project conducted in a Catholic parish in the United States. © 2003 Wiley Periodicals, Inc.
|
2022-12-24T20:31:40.276Z
|
233,283,064 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5478/MSL.2020.11.4.77",
"MAG": "3119563652",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Characterization of the various chemical aspects of composite polymers is important for quality control of manufactured polymers. In this study, we compared three suitable matrices (α cyano-4-hydroxycinnamic acid [CHCA], 2,5 dihydroxy benzoic acid [2,5-DHB], and dithranol), to characterize various synthetic polymers by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Although the spectra obtained with the CHCA and 2,5-DHB matrices were generally good, in certain samples ghost peaks disappeared only when dithranol was used as the matrix. Furthermore, we examined the use of sodium trifluoroacetate (NaTFA) as an additive to reduce interference by metals and copolymers in the spectra. In conclusion, appropriate selection of a matrix, according to the characteristics of the polymer, and the use of additives to improve sensitivity are important considerations for polymer analysis and development.
|
2022-02-07T21:51:29.196Z
|
145,643,840 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/019263657906342727",
"MAG": "2117561218",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
items sets out principles of learning in observable behavior patterns. This instrument is designed to identify obstacles to success in learning. The process of teacher-supervisor interaction is discussed in terms of RAD-retelling, agenda, and discussion components. Despite a cumbersome syntax, and unnecessary chatter which hinders easy clarity, here is a book for practitioners interested in clinical supervision and/or interaction analysis models. This book will appeal to those who wish to approach supervision of instruction in a systematic mode. While it is unfortunate that the author has not field tested his
|
2022-02-09T06:25:43.815Z
|
117,531,669 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0022112063000690",
"MAG": "270762961",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This note describes the slow magneto-hydrodynamic flow of hydrochloric acid in a helix. At very low Reynolds number a transverse magnetic field is found to retard the flow in agreement with existing theory and with existing experimental results obtained using mercury. At higher Reynolds numbers where secondary flow in a helix becomes important the transverse magnetic field is found to reduce this secondary flow.
|
2022-05-08T22:21:25.694Z
|