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122,912,424 |
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A vacuum‐ultraviolet bending‐magnet beamline for circular dichroism (CD) experiments has been designed. To maximize the photon flux and minimize the focused beam size, a cylindrical mirror and a cylindrical grating with independent optical functions are utilized. The beamline can collect a 30 mrad horizontal by 7 mrad vertical solid angle of synchrotron radiation. By using a 600 grooves/mm grating, the calculated photon flux is greater than 1×1013 photons/sec and the focused beam size is 0.4 mm×0.65 mm for the spectral range from 130 nm to 330 nm with the energy resolving power set at 1000. The linear polarization degree is better than 75% and can be increased to 90% by reducing the vertical acceptance angle down to 2 mrad. In addition to the high flux mode described above, this beamline can also be operated in a high resolution mode. By using a 1200 grooves/mm grating, a resolving power greater than 10,000 can be achieved for the spectral range from 180 to 330 nm. This beamline can provide photon flux as...
|
2022-02-09T18:51:51.729Z
|
213,820,364 |
{
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"DOI": "10.26905/nomosleca.v5i2.3409",
"MAG": "2989789912",
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"license": "CCBYSA",
"status": "GOLD",
"url": "https://jurnal.unmer.ac.id/index.php/n/article/download/3409/1942"
}
|
Abstract The issue of violence against women can be found in abundance within the mass media news. Quoting the Indonesia’s National Committee on Violence Against Women (National Committee of Women) in 2017, there were 348,446 cases of violence against women. The data from National Committee of Women shows that there is a high percentage of sexual abuse within the domain of domestic or personal violence as well as community and public violence. The volume of news related to sexual abuses have been rising ever since the Police-General Tito Karnavian gave a controversial statement in October of 2017. As quoted from BBC Indonesia in an exclusive interview with Tito Karnavian, Tito said that in cases of rape accusations, the police sometimes must ask if the victim feels comfortable. This statement sparked a reaction from the public. Women activists highlighted Tito’s statement and consider the questions to be insensitive because they ignore victims’ psychological condition. Online news portal Titro.id actively discuss the development of Tito’s controversial statement. Not only does Tirto.id presents the news on the subject matter, they also conduct deep investigations involving both parties: the police force and the survivors of sexual abuses. Tirto.id was also present in a funding night to support the work of sexual abuse survivors in 11 November 2017 in Kantor Dagang Serikat Islam, Central Jakarta. The report was written by a journalist of Tirto.id in the “In Depth” rubric or exhaustive reports in the form of information gathered from attending the event. In order to research this topic, the researcher used the critical discourse analysis technique. This research will be analyzed using Norman Fairclough’s scalpel. The outcome of this research shows that, within the textual analysis, both lexically and grammatically, Tirto.id uses dictions that imply supportive attitude towards the victims and survivors of sexual abuse, for example, the use of “ tegas ” or “firm”. Tirto.id also chooses negative adjectives such as “ bereaksi keras ” (“reacted violently”) and “ perilaku kasar bahkan kejam ” (”violent or even cruel behavior”) to be associated with the perpetrators of sexual violence. The use of active sentences indicates that Tirto.id reinforces the presence of actors of sexual violence from the text. Which often media ignored when reported of sexual violence. Keywords: Critical Discourse Analysis, Norman Fairclough, news, sexual abuse.
|
2022-04-22T04:39:38.433Z
|
81,924,057 |
{
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"ArXiv": null,
"DOI": "10.12816/0047824",
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|
Introduction : Mixed venous oxygen saturation (SvO2), is an invasive monitoring technique that reflects the balance between systemic oxygen transport and tissue oxygen consumption. Whereas tissue oxygen saturation (StO2) is a noninvasive technique that allows early detection of tissue hypoperfusion. The purpose of this study is to evaluate StO2 in patients undergoing elective coronary surgery: single cardiopulmonary bypass (CPB), and to find a correlation between StO2 and SvO2. Material and Methods : All patients scheduled for elective coronary surgery from May to July 2013, were included in the study. The anesthetic management and hemodynamic monitoring were the same. The following parameters: BP, HR, CI, SaO2, SvO2, StO2 at the eminence thenar, Hb and ΔPCO2 were monitored at the following times : T1: before anesthesia induction, T2 : after induction, T3 : 30 min after the beginning of CPB, T4 : after the weaning from CBP, T5 : H 12, at D1, D2 and at the occurrence of an adverse outcome such as anemia, hypotension, arrhythmia, hypoxia, fever with or without chills.. Results : Forty-five patients were included in this prospective study. Forty patients had 63 events : low cardiac output, isolated hypotension, hypoxia, anemia, AFib and atrial flutter. There was no statistically significant difference in StO2 from pre-induction till up to 2 days postoperatively, except after the weaning from CPB and 12 hours postoperatively. No correlation was noted between SvO2 and StO2 during the events that occurred both during and after the operation. Conclusion : Microcirculation at the eminence thenar may be altered after CPB. This fact is reflected by the decrease in StO2 that was noted immediately after CPB and that returned to normal 12 hours postoperatively. However, StO2 is not correlated with SvO2 upon the occurrence of an event during or after elective cardiac surgery. Further studies are needed to show the benefit of this noninvasive monitoring in cardiac surgery.
|
2022-07-19T07:19:50.620Z
|
34,312,538 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.2042-7158.1981.tb13875.x",
"MAG": "2147101508",
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|
Rondeau. D. B., Jolicoeur, F. B., Belanger, F., Barbeau, Smith, D. F., Vestergaard, P. (1979) J. Neural Trans. 46: A. (1978) Pharmacol. Blochem. Behav. 9: 76%775 215-223 Sa nOk, J . 7 LaBella* F. S. (l981a) Eur. J. Pharmacol. 70: Waddin ton, J. L., Cross, A. L. (1979) Neurosci. Lett,, 14: 3.3-1 10 123-137 Sawynok, J., LaBella, F. S. (1981b) Neuropharmacol. in the press Waldmeier, P. C., Fehr, B. (1978) Eur. J. Pharmacol. 49:
|
2022-09-13T12:47:04.519Z
|
8,201,201 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1399-0004.2008.01097.x",
"MAG": "1978966994",
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"license": null,
"status": null,
"url": null
}
|
Familial amyloidotic polyneuropathy (FAP) is a monogenic disease caused by mutations in the transthyretin (TTR) gene. The phenotype of the most common TTR mutation, V30M, varies within and between populations. Oxidative stress and protein misfolding are cellular processes involved in the development of FAP. Because the mitochondria are important for both these processes, we investigated if mitochondrial haplogroups are related to age at onset of the disease in Swedish and French FAP patients. Mitochondrial haplogroup analysis was performed on 25 early‐onset (below 40 years) and 29 late‐onset (above 51 years) Swedish FAP patients. DNA from 249 Swedish individuals served as controls. In addition, 6 early‐onset and 17 late‐onset French FAP patients were examined with 25 French controls. The haplogroup distribution among late‐onset Swedish and French cases was similar to that found in the general populations, whereas among early‐onset cases a different haplogroup distribution was seen. The relatively rare haplogroup K was significantly more common among early‐onset cases. Our findings substantiate the suggestion that a genetic component, still to be found, affecting mitochondrial function has an impact on the amyloid generating process in transthyretin amyloidosis.
|
2022-12-12T19:59:12.763Z
|
16,076,438 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1093/bioinformatics/bth495",
"MAG": "2099889778",
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},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/bioinformatics/article-pdf/21/2/275/459374/bth495.pdf"
}
|
UNLABELLED
Gene Ontology (GO) annotations have become a major tool for analysis of genome-scale experiments. We have created OntologyTraverser--an R package for GO analysis of gene lists. Our system is a major advance over previous work because (1) the system can be installed as an R package, (2) the system uses Java to instantiate the GO structure and the SJava system to integrate R and Java and (3) the system is also deployed as a publicly available web tool.
AVAILABILITY
Our software is academically available through http://franklin.imgen.bcm.tmc.edu/OntologyTraverser/. Both the R package and the web tool are accessible.
CONTACT
cashaw@bcm.tmc.edu
|
2022-12-15T14:22:04.180Z
|
117,773,735 |
{
"externalids": {
"ACL": null,
"ArXiv": "1101.1742",
"DOI": "10.1063/1.3615072",
"MAG": "1576049903",
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},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1101.1742"
}
|
We have used the Green Bank Telescope at 350 MHz to search 50 faint, unidentified Fermi γ‐ray sources for radio pulsations. So far, these searches have resulted in the discovery of 10 millisecond pulsars, which are plausible counterparts to these unidentified Fermi sources. Here we briefly describe this survey and the characteristics of the newly discovered MSPs.
|
2022-12-20T21:12:58.246Z
|
2,103,611 |
{
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"ArXiv": null,
"DOI": "10.3409/FB60_3-4.107-119",
"MAG": "2007971513",
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|
Expression of transcriptor factors MyoD, Myf5, myogenin and MRF4 forms the basis of myogenesis. In Acrania, Pisces and Amphibia, as in Aves, myogenesis is initiated by MyoD. In Mammalia expression of Myf5 initiates myogenesis. Signal proteins Wnt and Shh induce the expression of genes encoding for MyoD or Myf5. In fishes and amphibians expression of MyoD starts in non-segmented mesoderm and then in myotomal cells. In birds and mammals expression of MyoD or Myf5 is initiated in the cells of the dermatomyotome. Embryonic myotomes are post-mitotic. Proliferating cells Pax3 and Pax7-positive and mesenchymal cells take part in the growth of myotomal muscles. Cells migrating to the limb bud contain regulatory proteins Six4/Six1, Pax3, Lbx1 and c-met. Rectus abdominis develops from cells that contain Pax3 and Lbx1.
|
2022-12-30T05:23:01.506Z
|
163,698,292 |
{
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"ArXiv": null,
"DOI": "10.1017/S0009640716000378",
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|
and their groundbreaking scholarship however flawed. The book’s title quotes Frazer’s The Golden Bough (vol. 1, 1st ed. [1890], xi), where Frazer identifies “‘the central idea’ of the work as ‘the conception of the slain god’” who dies and rises (40). This phrase designates Frazer’s insight that the passion and death of Jesus of Nazareth was nothing more than the acting out of ancient tribal customs of homeopathic cleansing or the resolving of cultural problems by scapegoating. In so underscoring this signal event in Jesus’s life (at least for Christians), Frazer seems to imply that his underlying agendum is to disclose Christianity as essentially nothing more than the reenactment of magical customs long ago invented by “savages” and naturally embedded in the human race; in other words Christianity with its ritual accoutrement is merely a more sophisticated form of primitive magic that, having failed, morphed into religion. Later anthropologists such as Evans-Pritchard, Douglas, and the Turners forcefully challenged this reductionism, and set social and cultural anthropology on a scientifically more respectable trajectory. This, it seems to me, is the primary burden of Larsen’s study, though it is a burden lifted by sophisticated wit and graceful prose. Highly recommended to advanced general readers as well as to specialists.
|
2022-02-08T20:47:54.449Z
|
112,883,239 |
{
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"ArXiv": null,
"DOI": "10.1049/PBEW023E_CH9",
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|
Stripline is often used as a generic term for any transmission line consisting of a thin planar conductor supported on a dielectric sheet parallel to an earthed metallic plane. Symmetrical stripline has the conductor in the region between two earthed metallic conductors, and is sometimes called triplate line. It has the advantage that the microwave field is enclosed and is symmetrical and can be analysed from electrostatic principles assuming a pure TEM-mode. It can be constructed with a printed conductor sandwiched between two dielectric plates and their ground planes. A good summary of stripline design theory is given by Gupta, Garg and Chadha,' who quote all the formulas needed to determine the characteristic impedance and loss of the line and the corresponding inverse design formulas. The most accurate empirical formulas have been given by Wheeler, who also publishes some curves which may be used for design. Some curves of characteristic impedance for some particular standard sizes of stripline substrate are given in the 'Microwave Engineers' Handbook'.
|
2022-02-10T02:55:00.446Z
|
60,413,838 |
{
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"ArXiv": null,
"DOI": "10.21236/ada494810",
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|
Abstract : A fundamental challenge in designing networked control systems is that communication and control are not. in general, decoupled from each other. In order to address this challenge, the methods used in this project fundamentally integrated the tools, capabilities and constraints of both control theory and networking. The proposed solution enabled leveraging of existing seminal works in both fields. It also allowed for a cross-layer rethinking of the wireless networks for control applications. In particular, results both in theory and experiment showed that the above analysis can be extended and used to balance the performance of the controller and energy efficiency of communication schemes. Via an integrated set of simulations, the proposed design was illustrated not only in terms of the dynamical performance of formations, e.g. rate of convergence, but also in terms of energy efficiency and communication overhead. Vehicles were modeled as constant speed with controlled heading and were given the task of inducing the group centroid to track a target. Dynamic communication was incorporated via discretization of the dynamics, and nonlinear coordinated control was based on oscillator models. Results were demonstrated in simulation and in hardware.
|
2022-02-11T15:50:22.248Z
|
213,008,711 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.35366/rsc191d",
"MAG": "2999240351",
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},
"license": null,
"status": "GOLD",
"url": "https://www.medigraphic.com/pdfs/simulacion/rsc-2019/rsc191d.pdf"
}
|
Introducción: Adquirir competencias en cirugía laparoscópica requiere completar largas curvas de aprendizaje que son susceptibles de acortarse mediante el entrenamiento simulado. Sin embargo, las instancias de formación de este tipo suelen ser breves, esporádicas y poco costo-efectivas. Como ocurre en otras disciplinas, contar con un formato de entrenamiento continuo a modo de "gimnasio" permitiría mejorar la adquisición de habilidades. Objetivos: Describir la implementación de un gimnasio quirúrgico donde realizar programas de aprendizaje laparoscópico dirigidos a profesionales laparoscopistas. material y métodos: Estudio descriptivo. Se implementó un espacio físico donde realizar entrenamiento tutorizado por instructores expertos en educación médica y laparoscopia. Se ofrecieron a los alumnos cuatro cursos de simulación para el desarrollo de habilidades básicas y avanzadas de laparoscopia y la posibilidad de asistir a entrenar bajo su propia disponibilidad de tiempo. Resultados: En siete años se han formado 435 personas en laparoscopia, todas ellas en laparoscopia básica, 240 en laparoscopia avanzada, 62 en el módulo de laparoscopia esofagogástrica y bariátrica (EGB) y 11 en laparoscopia hepatobiliar y pancreática (HBP). La evaluación por parte de los asistentes externos como residentes es positiva. Conclusiones: El establecimiento de un gimnasio de simulación para el desarrollo y mantenimiento de habilidades quirúrgicas es una opción factible y atractiva para residentes y cirujanos. AbstrAct
|
2022-08-20T12:03:09.058Z
|
219,012,742 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4000/ejas.15671",
"MAG": "3021208588",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://journals.openedition.org/ejas/pdf/15671"
}
|
Fred Moten, Black and Blur, (Vol. 1. consent not to be a single being) Duke University Press, 2017. Pp.360. ISBN 978-0-8223-7016 Christine Okoth, University of Warwick To many, the scholar and poet Fred Moten is best known as one of the authors of the manifesto The Undercommons (2013), co-written with Stefano Harney who was once Deputy Director of the School of Business and Management at Queen Mary, University of London. Moten and Harney’s poetic critique of the university began circulating...
|
2022-09-02T05:18:38.111Z
|
202,159,370 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3307339.3343466",
"MAG": "2972690606",
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},
"license": null,
"status": "CLOSED",
"url": null
}
|
Recent integrative analyses using data from TCGA permit GWAS investigation of the genetic variants function, providing more insight than single-platform approaches. Although there has been much progress, the integration across data sets and data types remains limited. In this work we illustrate a workflow, based on the use of GMQL-Web, for combining private cancer datasets with datasets of genomic features and biological/clinical metadata sourcing from ENCODE, Roadmap Epigenomics, TCGA, as well as annotations from GENCODE and RefSeq. GMQL-Web is a web-based interface with the goal of providing a user-friendly intuitive environment for bioinformaticians and biologists who need to query genomic processed data (including public dataset not already available in the GMQL Repository) and combine them with their private datasets. Finally, we present a case study that illustrates the workflow steps to find samples extracted from a pharmacogenomic drug metabolism multi-gene platform, i.e. the Affymetrix DMET Plus platform that contain single-nucleotide polymorphisms (SNPs) that overlap with exon regions. The DMET platform is able to identify the relationship among the patients' genomic variations and drug metabolism by detecting SNPs on genes related to drug metabolism. From the obtained result, we identify only the SNPs overlapping with genes whose expression level is above a given threshold.
|
2022-09-08T12:35:58.209Z
|
208,631,233 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ECCE.2019.8913032",
"MAG": "2991079549",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper the design and implementation of a single-stator double-rotor fractional-slot concentrated-winding (FSCW) axial-flux permanent-magnet (AFPM) machine with modular Soft magnetic composites (SMC)stator and oil immersed forced cooling are presented. Shorter end-winding length and higher fill factor with rectangular copper wire can be realized by employing the yokeless and segmented stator. A fully sealed stator with oil-immersed cooling is proposed to enable a 20A/mm2 current density in the armature windings for stable operation. Meanwhile, the robustness of stator and rotor are taken into account due to the stator modularity weakening effect on strength. The FEA is used to validate the electromagnetic and mechanical performance. The construction and experimental verification of a full-scale 30kW prototype are elaborated to verify the predicted performances in terms of torque, efficiency and cooling.
|
2022-09-30T01:58:48.042Z
|
250,480,778 |
{
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"ArXiv": null,
"DOI": "10.2172/4279994",
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"license": null,
"status": "GREEN",
"url": "https://escholarship.org/content/qt0n6472b5/qt0n6472b5.pdf?t=p0hhah"
}
|
The relation between switching speed of a trigger circuit and the gain bandwidth (GBW) of an amplifier is discussed, A special series connection of two tubes - referred to as a dynamic plate-load amplifier - is then pre sented and analyzed, It is shown that the dynamic plate-load amplifier may have three times the advantage in GB W over a conventional amplifier using the same tube type. This GB W improvement, recommends its utilization in fast trigger circuits .
|
2022-12-02T10:47:26.830Z
|
122,301,774 |
{
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"ArXiv": null,
"DOI": "10.1063/1.872271",
"MAG": "2028583138",
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}
|
The world’s first high-power auxiliary heating experiments in a tight aspect ratio (or spherical) tokamak have been performed on the Small Tight Aspect Ratio Tokomak (START) device [Sykes et al., Nucl. Fusion 32, 694 (1992)] at Culham Laboratory, using the 40 keV, 0.5 MW Neutral Beam Injector loaned by the Oak Ridge National Laboratory. Injection has been mainly of hydrogen into hydrogen or deuterium target plasmas, with a one-day campaign to explore D→D operation. In each case injection provides a combination of higher density operation and effective heating of both ions and electrons. The highest β values achieved to date in START are volume average βT∼11.5% and central beta βO∼50%. Already high, these values are expected to increase further with the use of higher beam power.
|
2022-12-03T11:33:01.187Z
|
195,879,257 |
{
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"ArXiv": null,
"DOI": "10.1080/10962247.2019.1640805",
"MAG": "2960600144",
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},
"license": "CCBY",
"status": "HYBRID",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/10962247.2019.1640805?needAccess=true"
}
|
ABSTRACT A method has been developed to estimate the environmental impact of wheel loaders used in earthmoving operations. The impact is evaluated in terms of energy use and emissions of air pollutants (CO2, CO, NOx, CH4, VOC, and PM) based on the fuel consumption per cubic meter of hauled material. In addition, the effects of selected operational factors on emissions during earthmoving activities were investigated to provide better guidance for practitioners during the early planning stage of construction projects. The relationships between six independent parameters relating to wheel loaders and jobsite conditions (namely loader utilization rates, loading time, bucket payload, horsepower, load factor, and server capacity) were analyzed using artificial neural networks, machine performance data from manufacturer’s handbooks, and discrete event simulations of selected earthmoving scenarios. A sensitivity analysis showed that the load factor is the largest contributor to air pollutant emissions, and that the best way to minimize environmental impact is to maximize the wheel loaders’ effective utilization rates. The new method will enable planners and contractors to accurately assess the environmental impact of wheel loaders and/or hauling activities during earthmoving operations in the early stages of construction projects. Implications: There is an urgent need for effective ways of benchmarking and mitigating emissions due to construction operations, and particularly those due to construction equipment, during the pre-construction phase of construction projects. Artificial Neural Networks (ANN) are shown to be powerful tools for analyzing the complex relationships that determine the environmental impact of construction operations and for developing simple models that can be used in the early stages of project planning to select machine configurations and work plans that minimize emissions and energy consumption. Using such a model, it is shown that the fuel consumption and emissions of wheel loaders are primarily determined by their engine load, utilization rate, and bucket payload. Moreover, project planners can minimize the environmental impact of wheel loader operations by selecting work plans and equipment configurations that minimize wheel loaders’ idle time and avoid bucket payloads that exceed the upper limits specified by the equipment manufacturer.
|
2022-12-09T19:05:19.717Z
|
54,904,698 |
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"DOI": "10.1163/156856104840273",
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"url": null
}
|
During chemical-mechanical polishing (CMP), wafers are subjected to various particle sources such as slurry, polishing pads and polishing machines. Consequently, wafer post-CMP cleaning is crucial in micro- and nano-manufacturing to improve yield. In conventional cleaning process, the wafer is subjected to forces whose magnitudes are large enough to potentially cause substrate damage. This damage concern is becoming more severe as the characteristic feature size shrinks to sub-100-nm region. The development of dry, rapid, non-contact and non-destructive particle removal methods has been emerging as a critical requirement for post-CMP cleaning. In recent years a novel technique for particle removal using the pressure field generated by pulsed laser-induced plasma (LIP) has been introduced for cleaning surfaces and trenches. In the current study, it is demonstrated that the LIP removal technique is capable of removing ceria CMP particles with size of 100 nm and above without any substrate damage. The results reported in this study prove that LIP can also be applied over extended areas for post-CMP cleaning. It is possible to remove smaller particles at lower gap distances but the minimum particle size that can be removed is limited by the risk of substrate damage. Results reported in this study indicate that the LIP particle removal technique has significant potential for post-CMP cleaning in the near future.
|
2022-12-12T05:46:20.162Z
|
235,493,756 |
{
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"DOI": "10.1080/21691401.2021.1939709",
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"license": "CCBY",
"status": "GOLD",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/21691401.2021.1939709?needAccess=true"
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|
Abstract The present study aimed to investigate the brain targeting efficacy of Lamotrigine (LTG) loaded PLGA nanoparticles (LTG-PNPs) upon intranasal administration. LTG-PNPs were fabricated through the emulsification-solvent evaporation technique and evaluated for % Entrapment efficiency, particle size, in-vitro release, surface morphology, crystallinity, ex-vivo permeation & thermal behaviour. Biodistribution, gamma scintigraphy, and pharmacodynamic studies were performed in BALB/c mice, New Zealand rabbits, and Wistar rats respectively. LTG-PNPs exhibited % EE 71%; particle size 170.0 nm; Polydispersity index 0.191; zeta potential −16.60 mV. LTG-PNPs exhibited a biphasic release pattern. Biodistribution and gamma scintigraphy studies proved a greater amount of LTG in the brain following intranasal delivery of LTG-PNPs in comparison to LTG-SOL. Pharmacodynamic studies demonstrated delayed seizure onset time with LTG-PNPs in comparison to LTG-SOL. Intranasal administration of LTG-PNPs provided prolonged release, higher bioavailability, and better brain targeting bypassing the BBB. The developed formulation could be administered as a once-a-day formulation that would reduce the dosing frequency; dose; dose-related side effects; cost of the therapy and would be beneficial in the management of epilepsy as compared to the LTG-SOL. However, the proof of concept generated through these studies needs to be further validated in higher animals and human volunteers. Graphical Abstract
|
2022-12-18T17:05:44.338Z
|
13,311,213 |
{
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"DOI": "10.1158/1541-7786.MCR-14-0201",
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}
|
Transforming growth factor beta (TGFβ) proteins are multitasking cytokines, in which high levels at tumor sites generally correlate with poor prognosis in human patients with cancer. Previously, it was reported that TGFβ downregulates the expression of ataxia telangiectasia–mutated (ATM) and mutS homolog 2 (MSH2) in breast cancer cells through an miRNA-mediated mechanism. In this study, expression of a panel of DNA-repair genes was examined, identifying breast cancer 1, early onset (BRCA1) as a target downregulated by TGFβ through the miR181 family. Correlations between the expression levels of TGFβ1 and the miR181/BRCA1 axis were observed in primary breast tumor specimens. By downregulating BRCA1, ATM, and MSH2, TGFβ orchestrates DNA damage response in certain breast cancer cells to induce a “BRCAness” phenotype, including impaired DNA-repair efficiency and synthetic lethality to the inhibition of poly (ADP-ribose) polymerase (PARP). Xenograft tumors with active TGFβ signaling exhibited resistance to the DNA-damaging agent doxorubicin but increased sensitivity to the PARP inhibitor ABT-888. Combination of doxorubicin with ABT-888 significantly improved the treatment efficacy in TGFβ-active tumors. Thus, TGFβ can induce “BRCAness” in certain breast cancers carrying wild-type BRCA genes and enhance the responsiveness to PARP inhibition, and the molecular mechanism behind this is characterized. Implications: These findings enable better selection of patients with sporadic breast cancer for PARP interventions, which have exhibited beneficial effects in patients carrying BRCA mutations. Mol Cancer Res; 12(11); 1597–609. ©2014 AACR.
|
2022-12-20T03:20:32.994Z
|
136,551,340 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1177/0021955X8201800402",
"MAG": "1978280494",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
or a three-phase system. Two-phase syntactic foams consist of microspheres dispersed in a resin, either in loose or close-packed structures. Three-phase foams consist of a resin, microspheres and air voids which are finely dispersed in the binding resin. The lowest density possible with a two-phase system is for a closepacking arrangement of the light spheres and any further density decrease requires the introduction of air voids to the resin to form a three-phase system. The light weight syntactic foams are characterized by their good mechanical and useful electrical properties. The close-packed spheres form a stress-bearing structure capable of withstanding relatively high compressive stresses. At low resin concentrations, failure oc-
|
2022-12-21T01:00:32.949Z
|
1,747,852 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1532-5415.1991.tb02909.x",
"MAG": "1983953414",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Polyarticular gout may be misdiagnosed in the elderly. This reflects the confusing clinical presentation of "diuretic gout" in the elderly, characterized by polyarticular onset, subacute symptoms, hand involvement, and early development of tophi. A misdiagnosis of rheumatoid arthritis can lead to poor treatment of gout, failure to recognize underlying renal insufficiency, and associated cardiac risks. Hyperuricemia may reflect systemic ATP depletion in acutely ill patients and thus represents a predictor for mortality. Medical treatment of polyarticular gout in elderly patients with compromised cardiac and renal function requires recognition of the clinical profile and consideration of the increased toxicity from standard therapies.
|
2022-08-25T13:54:36.628Z
|
35,418,013 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TNS.2004.828805",
"MAG": "2108400463",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A new data acquisition (DAQ) system for the H1 Luminosity measurement at HERA II has been commissioned in 2002 in parallel with the machine; aiming at 1% precision measurement on each of the 186 colliding bunches in less than 1 min, it is based on a commercial mezzanine processing card mounted on a VME station, reading custom-designed analog-to-digital converter (ADC) and time-to-digital converter (TDC) VME cards via a dedicated bus. The protocol on this 20-MHz data bus is implemented on a field-programmable gate array (FPGA), which also performs the triggering for two acquisition modes (triggered and by train), the synchronization of the digitization boards and the formatting of the data in an internal FIFO. The data are then fetched and histogrammed by a dedicated PowerPC processor. The online analysis of the distributions takes place on the VME station. Maximum histogramming rates of 0.5 MHz have been reached in the train mode (three channels readout) and about 110 kHz in the triggered mode (26 channels readout).
|
2022-02-12T08:26:24.377Z
|
229,691,097 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0244217",
"MAG": null,
"PubMedCentral": "7755280"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244217&type=printable"
}
|
Marine bacteria employ various strategies to maintain their competitive advantage over others in a mixed community. The use of Type VI Secretion Systems (T6SS), a protein secretion apparatus used as a molecular weapon for interbacterial competition and eukaryotic interactions, is one of the competitive strategies that is least studied among heterotrophic bacteria living in the water column. To get an insight into the temporal and spatial distribution of bacteria with T6SS in this portion of the marine environment, we examine the presence and abundance of T6SS-bearing bacteria at both local and global scales through the use of metagenome data from water samples obtained from the coast of Monterey Bay and the TARA Oceans project. We also track the abundance of T6SS-harboring bacteria through a two-year time series of weekly water samples in the same coastal site to examine the environmental factors that may drive their presence and abundance. Among the twenty-one T6SS-bearing bacterial genera examined, we found several genera assume a particle-attached lifestyle, with only a few genera having a free-living lifestyle. The abundance of T6SS-harboring bacteria in both niches negatively correlates with the abundance of autotrophs. Globally, we found that T6SS genes are much more abundant in areas with low biological productivity. Our data suggest that T6SS-harboring bacteria tend to be abundant spatially and temporally when organic resources are limited. This ecological study agrees with the patterns observed from several in vitro studies; that T6SS could be an adaptive strategy employed by heterotrophic bacteria to obtain nutrients or reduce competition when resources are in limited quantity.
|
2022-10-21T16:58:07.970Z
|
37,306,257 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1152/ajpheart.00732.2013",
"MAG": "2123975199",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc3949071"
}
|
The contractile activity of muscle cells lining the walls of collecting lymphatics is responsible for generating and regulating flow within the lymphatic system. Activation of PKC signaling contributes to the regulation of smooth muscle contraction by enhancing sensitivity of the contractile apparatus to Ca(2+). It is currently unknown whether PKC signaling contributes to the regulation of lymphatic muscle contraction. We hypothesized that the activation of PKC signaling would increase the sensitivity of the lymphatic myofilament to Ca(2+). To test this hypothesis, we determined the effects of PKC activation with phorbol esters [PMA or phorbol dibutyrate (PDBu)] on the contractile behavior of α-toxin-permeabilized rat mesenteric and cervical lymphatics or the thoracic duct. The addition of PMA or PDBu induced a significant increase in the contractile force of submaximally activated α-toxin-permeabilized lymphatic muscle independent of a change in intracellular Ca(2+) concentration, and the Ca(2+)-force relationship of lymphatic muscle was significantly left shifted, indicating greater myofilament Ca(2+) sensitivity. Phorbol esters increased the maximal rate of force development, whereas the rate of relaxation was reduced. Western blot and immunohistochemistry data indicated that the initial rapid increase in tension development after stimulation by PDBu was associated with myosin light chain (MLC)20 phosphorylation; however, the later, steady-state Ca(2+) sensitization of permeabilized lymphatic muscle was not associated with increased phosphorylation of MLC20 at Ser(19), 17-kDa C-kinase-potentiated protein phosphatase-1 inhibitor at Thr(38), or caldesmon at Ser(789). Thus, these data indicate that PKC-dependent Ca(2+) sensitization of lymphatic muscle may involve MLC20 phosphorylation-dependent and -independent mechanism(s).
|
2022-12-21T05:44:59.555Z
|
15,840,589 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4081/cp.2012.e9",
"MAG": "2038531402",
"PubMedCentral": "3981348"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2039-7283/2/1/e9/pdf?version=1607023615"
}
|
A 42-year-old man patient presented with progressively increasing, occasionally painful lump in the left upper and central abdomen. Investigations revealed well-defined capsulated left adrenocortical carcinoma. Tumor was resected successfully along with left kidney. Tumor recurred in the abdominal surgical scar 1.5 years after surgery. We are reporting this case because of rarity of metastatic recurrence of an adrenocortical carcinoma in the abdominal surgical scar 1.5 years after resection of primary tumor.
|
2022-09-01T05:57:37.179Z
|
17,071,500 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2514/6.2009-2815",
"MAG": "2144510330",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Super-pressure balloons are currently under development by the NASA Balloon Program Office for use in stratospheric balloon missions. They are made of thin polyethylene film forming a sealed envelope that is contained by stiff meridional tendons. The film is subject to a state of stress whose details depend on the cutting pattern, stiffness of the film vs. stiffness of the tendons, etc. and the viscoelastic behavior in the film plays an important role. This paper extends the modeling approach presented by the same authors at the AIAA Balloon Systems Conference 2007. The current model captures nonlinear viscoelasticity in a wrinkled, anisotropic membrane, and the analysis has been successfully applied to several balloon designs. Because the effects of wrinkling on the stress history are modeled correctly, the behavior of the balloon can be simulated with high fidelity, starting from pressures as low as 5-20 Pa. The creep strains at selected points of a 4 m diameter balloon were measured using photogrammetry and the results were compared to results from the numerical model. At a pressure of 700 Pa the balloon had a maximum stress of 6.0 MPa in the meridional direction (2.5 MPa hoop stress) and meridional strains of up to 6.4% (-2.7% hoop strain). A detailed model of gore seams and tendon attachments provides insight into the asymmetry of the strain distribution that results from the actual asymmetry of the gore seams. This also allows the numerical replication of an experimentally observed pressure-dependent rotation of the end-fittings.
|
2022-08-23T22:51:40.018Z
|
5,962,835 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/etc.2436",
"MAG": "2106226209",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Andean streams drain metal‐rich bedrock and are subjected to an extreme altitude gradient, which may create highly selective conditions for life. The aim of the present study was to evaluate the combined effects of metals and altitude on benthic macroinvertebrate community composition in Andean streams. Metal‐rich sites were characterized by high metal concentrations and low pH, and high‐altitude sites were characterized by high ultraviolet‐B radiation and low concentrations of dissolved organic matter. Canonical correspondence analysis indicated that the patterns in faunal composition were best explained by metals followed by altitude, with dipterans and collembolans occurring mostly under harsh conditions of high altitude and high metal levels. Interaction between metals and altitude was most evident at metal‐rich sites. It is suggested that in Andean streams, metal leaching from igneous rock and altitude may be important factors confining benthic macroinvertebrate communities, reducing their numbers and changing their composition toward specialized taxa. Environ Toxicol Chem 2014;33:404–411. © 2013 SETAC
|
2022-12-17T08:14:26.788Z
|
22,344,231 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/000313481307901027",
"MAG": "60068509",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The implication of splenic contrast blush on computed tomography (CT) in blunt trauma patients and whether it is an indication for angioembolization (AE) remains controversial. Our objective was to determine whether CT blush and its subsequent treatment have any impact on outcomes in blunt trauma patients with low-grade splenic injuries. A retrospective review identified adult patients with splenic injury (American Association for the Surgery of Trauma grades 1 to 3) from blunt abdominal trauma who were evaluated with a CT scan over a 3.5-year period at a Level I trauma center. Patient groups analyzed included: observation patients with no CT blush (n = 110), observation patients with CT blush (n = 18), and AE patients with CT blush (n = 22). Patients with CT blush who were observed did not demonstrate significantly worse outcomes compared with the patients with no CT blush. Additionally, patients with CT blush who underwent AE did not show any significant improvement in outcomes compared with patients who were observed with CT blush. Our study suggests that CT blush does not predict worse outcomes for blunt trauma patients with low-grade splenic injury who underwent observation. Furthermore, AE does not seem to provide any advantage to this subset of patients.
|
2022-12-20T18:53:50.764Z
|
150,166,197 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/23752696.2018.1454264",
"MAG": "2891296438",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/23752696.2018.1454264?needAccess=true"
}
|
ABSTRACT Following previous research which showed the significance of learners’ self-efficacy and dispositions towards progression in school and university transition, we developed and validated similar measures for use in modelling undergraduate students’ Learning Gain (LG). We validated three dimensions of confidence using data from a sample of (mainly first year) undergraduate students in various departments of one major UK University which we call: ‘confidence in learning through…’ a) ‘traditional university transmission pedagogy’ (e.g. in lectures), b) ‘social means’ (e.g. working in teams), and c) ‘problem solving, reflection and critical thinking’. We explored psychometric properties of these measures and then focus on their association with other perceptions of students’ experience in HE and other measures of attainment. We then used these academic self-efficacy variables to inform (regression) models of LG. Finally, we discuss the prospects for measurements and modelling of LG involving dispositions and affect as well as attainment.
|
2022-12-31T06:17:39.104Z
|
84,589,636 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0021859600039265",
"MAG": "2043902366",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
SUMMARY The effect of three different growth rates from 15 to 40 kg live weight on some offal components of lambs was studied. The treatments were: high (H) ad-libitum feed intake, low (L) restricted feed intake and high-maintenance-high (HMH) ad-libitum feed intake from 15 to 25 kg followed by a 50-day period of weight stasis, which was followed by ad-libitum feeding. In each treatment, two animals were killed at 25, 30 and 35 kg and three animals at 40 kg. Analyses of covariance were used to compare linear regression equations representing results from each treatment using the logarithmic transformation of the allometric equation, y = axb. Differences between treatments were found for the weight of certain non-alimentary tract offals including the liver (H, HMH > L), kidney (H, HMH > L), skin (H, HMH > L) and hind-hooves (H < HMH, L). The slope of the regression for the heart, liver, kidney, and the combined trachea and lungs was greater in the HMH, than in the H, treatment. These differences in slope were attributed to a decrease in weight of each component in the HMH animals during weight stasis except for the lungs and trachea, where the greater slope was due to an increased weight of this component in the HMH animals killed at 40 kg. Fat-trimmed weights of the omasum, abomasum, small intestine and large intestine were greater in both the H and HMH animals than the L animals. The weights both of the rumen-reticulum and total alimentary tract (TAT) were less at 25 kg in HMH animals than in either H or L animals although, overall, the weight of TAT was greater in the H and HMH treatments than in the L treatment. A comparison of data for the H and HMH treatments showed that weight stasis decreased the weight of all separate parts of the alimentary tract, particularly the rumen-reticulum and the small intestine. Chemical analyses (water, N × 6·25 and ether extract) were conducted on four alimentary tract components, namely the combined rumen-reticulum and omasum (RRO) abomasum, small intestine and large intestine. The results of these analyses showed that composition was similar in the three treatments despite treatment effects on the weight of some parts of the tract. Chemical data were pooled across treatments to compare composition of the different alimentary tract components. This analysis showed that chemical composition was different both for all parts of the tract and for all chemical components with two exceptions. There was no difference between the RRO and small intestine for either water or ether extract. Common regression equations are presented for each component of the alimentary tract relating the weights of three chemical components to tissue weight. Water and protein content were more closely related to tissue weight than was ether extract. It is suggested that both water and protein content may show a sufficiently close relationship to tissue weight whereby they may be predicted from a knowledge of the latter, particularly the RRO and small intestine. There were no differences between treatments in the weights of fat trimmed from the alimentary tract despite treatment effects on either the weight of some parts of the tract or other offals. Apart from a greater weight of digesta in the small intestine in the H animals than in L animals relatively minor differences between treatments were found in the amounts of digesta in different parts of the tract.
|
2022-01-17T20:44:26.602Z
|
36,650,112 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1365-2929.2006.02450.x",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Context and setting Expert system programs follow the same rational steps as a human expert to solve a specific problem. Their use in teaching may be effective, as users can learn by observing the behaviour of the system. We developed an expert system for lymphoid pathology diagnosis, based on pattern recognition, the key to diagnosis in pathology. Why the idea was necessary A recent call for novel computer-based approaches to the teaching of pathology in European schools of medicine prompted our group to adapt and test our expert system for this purpose. What was done The modified expert system for lymphoid pathology knowledge (SEACOPALI) shows images selected for their similarity to a problem case. According to the pattern selected, further patterns and descriptive and diagnostic data are presented, requiring the user to focus on specific characteristics and offering differential diagnoses. A study was performed with 3 groups of 3rd-year medical students (n 1⁄4 101 students) who used either the SEACOPALI system, or SEACOPALI documentation or lymphoid pathology text plus ATLAS. Students were tested on their existing knowledge (pretest), after which they completed a questionnaire on 4 clinical cases using their respective learning resources (computer system or documentation or traditional materials). This was immediately followed by a second test of their knowledge (post-test). The expert system group also completed a questionnaire on the usability of the system. Evaluation of results and impact Performance of the test itself impacted positively on knowledge acquisition (correct results: 27Æ5% pretest versus 56Æ6% posttest), as reported in previous studies of problembased learning strategies. The expert system group achieved the highest level of learning in the histological diagnosis of lowand high-grade lymphomas (P < 0Æ05). The groups did not differ in their ability to diagnose Hodgkin’s lymphoma, but the expert system and the expert system documentation groups showed greater skill in pattern recognition than the traditional learners (P < 0Æ001); 68Æ6% of the expert system group said they would recommend its use to their peers and 42Æ9% indicated they would like to use the system daily. Results were validated by using the Kruskal–Wallis non-parametric test. These preliminary results indicate that use of the expert system assists acquisition of practical knowledge and pattern recognition and that the system would be optimally used as a complement to traditional teaching. The need for modifications to the system was revealed by the study, leading to the development of a new expert system prototype that incorporates a screen to display problem cases and can be used interactively by the student.
|
2022-02-12T07:31:23.463Z
|
247,367,108 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/su14063190",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2071-1050/14/6/3190/pdf?version=1646824315"
}
|
Rockburst disasters frequently occur in deep tunnels excavated by TBM (tunnel boring machine) under complex geological conditions in western China. Using FLAC3D, the characterization of a three-dimensional numerical model of a compound stratum tunnel excavated by TBM is conducted, based on a water transport project in Shanxi Province. Then, the characteristics of rockburst in deep hard and soft compound stratum tunnels excavated by TBM are revealed, and the energy criteria of the rockburst considering the rock brittleness are proposed. In addition, the prevention and control method of drilling pressure relief for rockburst has been investigated. Results show that: (i) the rockburst risk of compound stratum tunnel excavated using TBM is mainly in the upper-hard rock part, while there is no rockburst risk in the soft rock part; (ii) after the excavation of the tunnel, slight rockburst risk occurs first in the hard rock area of the tunnel vault, and then the rockburst risk gradually rises to the strong level at 7 m behind the working face, indicating the hysteresis of strong rockburst; (iii) the rockburst in the vault of the rock surrounding the compound stratum tunnel has the effect of forming the deepest area, gradually narrowing to both sides, showing a “V” shape, and the occurrence of rockburst may not be completed at one time; (iiii) borehole pressure relief can significantly reduce the rockburst risk of surrounding rock in a tunnel. The larger the borehole diameter and depth, the better the effect of rockburst prevention. In addition, the effect of borehole diameter is more significant than depth. The research results provide guiding references for the prevention and control of similar rockburst disasters in underground engineering.
|
2022-07-19T23:08:37.512Z
|
240,407,049 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15405/epiceepsy.21101.9",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://www.europeanproceedings.com/pdf/article/10.15405/epiceepsy.21101.9"
}
|
The first year of the university study is stressful for most students. In the context of open education, this problem is exacerbated, since the understanding of stress and how to cope with it among students of different cultures differ. There are studies on the differences in the perception of Stress between students of Eastern and Western cultures, individualistic and collectivist cultures. But the question arises whether there are differences in the Stress perception among students of the same cultural group. The goal of the study was to reveal the peculiarities of notions about Stress among Russians, Armenians, Tatars, Turks, and Chinese. More than 700 first-year university students were invited to participate in the study. Research methods included the analysis of dictionaries, directed associative experiment (Stimulus was word Stress), the pictographic technique (Stress image). The findings testified significant differences in the sensory, emotional, and temporal modalities of Stress perceptions among students of Eastern cultures (ANOVA, p = 0.000; multiple comparisons). The notions of Stress among Russian students are pronounced in sensory, emotional, and temporal modalities. The dominant emotional perception of Stress is characteristic of the Tatars. The Armenians and Chinese are distinguished by the severity of the spatial-temporal modality of Stress perception. The notions of Stress among Turkish freshmen are concrete and low-emotional. The data obtained are important to adapting the freshman and maintaining their psychological well-being.
|
2022-07-31T05:09:41.799Z
|
62,010,343 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5120/IJCA2015906626",
"MAG": "2202156267",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Recommender systems assist the consumers of service oriented environment to find out and select the most suitable services from a large number of available ones. Proposed paper is based on Personalized Recommendation System for medical assistance using keyword extraction. User can search doctor‟s profiles or hospital names according to doctor and hospital attributes. Natural Language Processing (NLP) is used to process user‟s ratings and reviews to compute system ratings. Depending on users rating and reviews, profiles are recommended. Medical-based Personalized Recommendation System computes similarity between given and collected attribute by using top-k query which is used to recommend each doctor profile and hospital name for each attribute in information retrieval. Personalized Recommendation system for medical assistance yields 0.06 satisfactions and 0.02 accuracy. General Terms Keyword Extraction ,Hybrid Filtering
|
2022-09-20T19:56:01.283Z
|
216,596,540 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/07448481.2020.1750413",
"MAG": "3018436747",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Objective This study examined relationships between prosocial factors including altruism, compassion, social connectedness, spirituality, and volunteerism and measures of health in college students. Participants: A total of N = 1,075 participants from four institutions across various regions of the U.S. were included. Methods: Participants were sent email invitation via student listserv to participate in a survey of health and prosocial factors that was open for one month. Results: Hierarchical linear regressions were completed to examine the influence of prosocial variables on perceptions of health and engagement in health behaviors. Social connectedness was a significant contributor to variance in all health measures, and the variables with the most variance explained were symptoms of depression (28.6%) and Health-Related Quality of Life (24.6%). Conclusions: Institutions should prioritize programing to enhance social connectedness and other prosocial behaviors because of the positive effect these factors can have on health and health behaviors.
|
2022-12-14T22:48:20.480Z
|
17,988,150 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/02635571211238545",
"MAG": "2080477994",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Purpose – The purpose of this paper is to examine the information gathering methods used during enterprise system (ES) selection among Polish organizations and to have IT consulting experts evaluate these methods, which will result in identification of the preferred approach for the information‐gathering task during system selection.Design/methodology/approach – The research has a qualitative exploratory design with grounded theory being the main research method. A mixed quantitative‐qualitative approach to data collection was used: an e‐mail‐based survey was used as an introductory stage to gather data on information‐gathering methods. The results of the survey were evaluated by ES experts during unstructured interviews. The interviews were then transcribed and coded according to the grounded theory coding techniques.Findings – The evaluation of selection approaches revealed that the approach to information gathering should depend on the level of configurability of the systems subject to selection. Two g...
|
2022-12-17T09:59:28.333Z
|
212,747,632 |
{
"externalids": {
"ACL": null,
"ArXiv": "2003.07925",
"DOI": "10.1063/5.0007989",
"MAG": "3102695742",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://iris.inrim.it/bitstream/11696/65500/1/12%20-%20Measurement%20of%20the%20heat%20flux%20normalized%20spin%20Seebeck%20coefficient%20of%20thin%20films%20as%20a%20function%20of%20temperature.pdf"
}
|
The spin Seebeck effect (SSE) has generated interest in the thermoelectric and magnetic communities for potential high efficiency energy harvesting applications and spintronic communities as a source of pure spin current. Understanding the underlying mechanisms requires characterization of potential materials across a range of temperatures; however, for thin films, the default measurement of an applied temperature gradient (across the sample) has been shown to be compromised by the presence of thermal resistances. Here, we demonstrate a method to perform low temperature SSE measurements where, instead of monitoring the temperature gradient, the heat flux passing through the sample is measured using two calibrated heat flux sensors. This has the advantage of measuring the heat loss through the sample as well as providing a reliable method to normalize the SSE response of thin film samples. We demonstrate this method with an SiO2/Fe3O4/Pt sample where a semiconducting-insulating transition occurs at the Verwey transition, TV, of Fe3O4 and quantify the thermomagnetic response above and below TV.
|
2022-12-19T10:25:28.197Z
|
58,908,853 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2147/CWCMR.S140673",
"MAG": "2742218058",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Chronic Wound Care Management and Research 2017:4 99–105 Chronic Wound Care Management and Research Dovepress
|
2022-12-29T18:18:58.821Z
|
241,199,906 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/oxan-db252370",
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},
"license": null,
"status": null,
"url": null
}
|
Subject
Reform of China's energy sector.
Significance
The government has recently taken steps to reform China’s energy sector, diversify the number of actors and increase the role of market forces. However, the state retains a dominant position in the sector.
Impacts
It could still be many years before the draft Energy Law of 2020 is formally adopted into law.
Measures to open up the oil and gas industry are likely to have little effect, especially at a time of low oil and gas prices.
New electricity and carbon markets will not achieve their potential in terms of economic efficiency and emissions reduction for many years.
|
2022-01-24T21:16:20.647Z
|
181,883,124 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/OSO/9780198833444.003.0019",
"MAG": "2945859198",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The focus is on two classic descriptions of birthdays occurring on the same day. That is, the probability that two people selected at random from 23 have the same birthday and a specific probability a person’s birthday matches a specific day.
|
2022-02-08T13:07:55.292Z
|
245,229,896 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/tem-1980-542x2021v2706",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.scielo.br/j/tem/a/DHpBSLM9HfRQqS7WDGxMFSd/?lang=pt&format=pdf"
}
|
Resumo: O objetivo deste trabalho é investigar a trajetória de Salustiano Gomes Ferreira (Saluzinho), dando especial atenção para o conflito mais marcante em que esteve envolvido, em Varzelândia (MG), no final da década de 1960. Buscamos compreender as suas próprias interpretações sobre o caso, as imagens veiculadas pela imprensa da época e as perspectivas de alguns atores envolvidos. Nesse sentido, discutimos as relações entre esse trabalhador, outros posseiros da região, seus adversários e movimentos sociais no campo, procurando compreender suas noções de direitos e sua perspectiva sobre o pensamento comunista. Dessa forma, acreditamos ser possível lançar alguma luz sobre as especificidades desse indivíduo, assim como sobre o significado de sua trajetória para um entendimento mais amplo.
|
2022-12-23T02:10:50.876Z
|
240,663,432 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.35940/ijitee.d1020.0394s220",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.35940/ijitee.d1020.0394s220"
}
|
With the agenda of developing smart cities there is huge demand for continuous power supply. Power distribution transformers play avital role in providing a reliable power supply. Failure of a transformer will lead to interruptions in power supply. Many parameters lead to transformer failures. Health monitoring of transformer using IoT technology may help take proactive maintenance steps instead of reactive maintenance. When we combine IoT with AI it will more effective and IoT devices will take decision on their own. This paper presents a conceptual framework of this concept which makes the IoT devices in the transformers to make real-time decisions with the use of AI.
|
2022-01-24T21:34:32.267Z
|
221,858,584 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5194/PIAHS-383-201-2020",
"MAG": "3087154968",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract. In order to fully use the newly-built hydrologic stations in small and medium rivers for flood warning and prevention, based on the technical line of the investigation and evaluation of flash flood disasters, different historical flood information of the warning river section was investigated, while the elevations of riverain houses were measured. The relationship between the stations and affected population has been established for the study region. According to integrated flood control capability of riverside residents, the characteristic water levers and rainfall threshold values were determined in this case. The results indicate that the warning and safety levels are 54.0 and 55.3 m, respectively. The analysis results show that the warning should be issued when the net rainfall intensity is 70 mm h −1 or 110 mm for 6 h condition. And considering the effectiveness of disaster avoidance, variable characteristic water levers of the hydrologic station for flood warning in different village were determined on the basis of the flood control capability of each village. The relationship between hydrologic numerical value and inundating influence was established in a one-to- n way.
|
2022-02-03T12:56:18.235Z
|
76,813,533 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3802/KJGO.2007.18.1.26",
"MAG": "2396149484",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective : To evaluate the efficacy of MRI in bladder or rectal invasion of cervical cancer. Methods : Between January 2000 and December 2005, 106 cervical cancer patients who underwent cystoscopy or sigmoidoscopy examination retrospectively compared with results of the MRI finding. A 5-point invasion score was used to determine bladder or rectal invasion in MRI (1 = no invasion, 3 = serosal invasion, 5 = definite mucosal invasion). Score of 3 or above was suspicious for both rectal and bladder invasion Results : Eighty one patients with negative for both rectal and bladder invasion in MRI were normal in cystoscopy and sigmoidoscopy. MRI identified 17 patients with suspected bladder invasion, 7 patients had confirmed bladder invasion in cystoscopy. MRI identified 11 patients with suspected rectal invasion, 1 patients had confirmed rectal invasion in sigmoidoscopy. The detection of rectal and bladder invasion by MRI had a negative predictive value of 100%. Conclusion : The use of a 5-point scoring system for predicting rectal or bladder invasion in MRI is accurate in detecting cervical cancer patients with no evidence of rectal or bladder invasion. The cervical cancer patients with no evidence of rectal or bladder invasion in MRI can obviate invasive cystoscopy and sigmoidoscopy.
|
2022-02-11T06:02:44.414Z
|
86,248,105 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1502-3931.2007.00014.X",
"MAG": "2131435165",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The origin of multicelled animal life required collagen-family molecules whose own formation depended on the availability of molecular oxygen. Cancers, by contrast, are characterized by their low use of oxygen. In discussing the relationship between the origin of multicelled life and the origin of cancer, it is useful to think in terms of tissues rather than individual cells or complete animals. When animal tissues are disturbed, their constituent cells may be partially released from the constraints of multicellularity. This permits or obliges cells to reactivate anaerobic metabolic ways used by their single-celled ancestors in the oxygen-deficient Precambrian seas. Inhibition or loss of cell respiration under such circumstances may cause reversion to glycolytic fermentation, a less efficient metabolic style that generates waste products that are retained, thereby producing excess cell-growth. Distortion of tissue architecture may ensue with impairment of cell-to-cell adhesion, thereby liberating individual cells. Cells freed from tissue constraints undergo Darwinian variation which leads to loss of differentiation and produces cell types that are incompatible with the normal functioning of tissues. These steps, which may manifest themselves as carcinogenesis, are not reversible by restoration of oxygen and in effect constitute a demergence from the metazoan state. The existence of cancer among diverse phyla and especially among domesticated animals, suggests that the risk of cancer may be an initial condition of complex multicellular life and that it remains preferentially associated with newly modified designs. If so, there would be therapeutic strategies that have not yet been adequately considered. □Cambrian explosion, cancer, cell differentiation, collagen, glycolysis, hard parts, metazoan origins.
|
2022-12-09T06:07:49.504Z
|
56,308,591 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4236/ENG.2013.54047",
"MAG": "2048275366",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A study of piles is quit complex and the estimation of carrying capacity is calculated from theoretical formula and load test results. The design resistance may be calculated using conventional static pile design theory. The pile founding depths should be predetermined before installation from a site geotechnical investigation. To ascertain the field performance and estimate load carrying capacities of piles, in-situ pile load tests should be conducted. In this study, field pile load test data is analyzed to estimate the ultimate load for end bearing piles. The investigated site is about 100 × 110 m located in Alexandria, Egypt. Geotechnical investigations at the site are carried out to a maximum depth of 45 m. Four borings have been done in field. The tests are conducted at the site for two skelton structure buildings to be constructed on raft foundation rested on piles executed by continuous flight auger. Four pile load tests are performed on 600 mmdiameters and 27 mlengths. Ultimate capacities of piles are determined according to different methods. It is concluded that the percentage of friction load carried by the shaft along the pile length is about 46% of total load while the percentage of load carried by the end bearing is 54% of total load. A new proposed method by the author is presented to calculate the ultimate capacity of pile from pile load test. The proposed method depends on the settlement of pile without taken into consideration the elastic deformation. An empirical formula is presented from the relationship between stress and settlement of pile due to friction and end bearing only after deducting the elastic deformation. However, the obtained results for the ultimate capacity of end bearing piles are considered to be more accurate than other methods. The proposed method appears to give bitter results that agrees well with the theoretical predictions. The proposed method is easier, quicker and more reliable.
|
2022-12-18T10:48:05.918Z
|
84,819,688 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00219266.1998.9655605",
"MAG": "2020436581",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The ideas of 290 Year 1 biology undergraduate students about cystic fibrosis, gene therapy, and gene screening have been explored using a multiple-choice-type questionnaire. Students were reasonably informed about the nature of cystic fibrosis disease, although many underestimated its prevalence. Fewer of the students understood the mechanism of inheritance of cystic fibrosis. Only a third of the students appreciated the way in which gene therapy is currently effected; many thought that ‘faulty’ genes could be removed and some even imagined that they could be repaired and replaced. A quarter of the students thought that testing for the cystic fibrosis gene would produce medical side-effects. In the affective domain, about half the group would wish to be tested, but a third were uncertain.
|
2022-07-01T04:16:33.674Z
|
116,930,942 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0027763000014501",
"MAG": "1571408736",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The well-known Thullen-Remmert-Stein’s theorem ([9], [7]) asserts that, for a domain D in CN and an n-dimensional irreducible analytic set S in D, a purely n-dimensional analytic set A in D — S has an essential singularity at any point in 5 if A has at least one essential singularity in S. In [1], E. Bishop generalized this to the case that A has the boundary of capacity zero in his sense. Afterwards, in [8], W. Rothstein obtained more precise informations on the essential singularities of A under the assumption dim A = 1. The main purpose in this paper is to generalize these Rothstein’s results to the case of arbitrary dimensional analytic sets.
|
2022-07-31T04:10:51.684Z
|
122,300,316 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.94283",
"MAG": "2035281945",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Constricted double‐heterojunction diode lasers have been life tested at 70 °C heatsink temperature and 3–4 mW/facet in cw operation. A median life of 7800 h is obtained at 70 °C, which extrapolates to 4×105 h median life at room temperature. The extrapolated mean time to failure at room temperature is in excess of 106 h. Single‐longitudinal‐mode cw operation is maintained after 10 000 h of accelerated aging at 70 °C.
|
2022-08-24T20:10:01.579Z
|
192,003,365 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5753/CBIE.WIE.2010.1235-1244",
"MAG": "2273709968",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Resumo: Esse estudo investigou a formacao de comunidades virtuais de aprendizagem (CVA). A pesquisa foi realizada com 18 alunos do terceiro semestre do curso de Graduacao semipresencial em Letras-Portugues da Universidade Federaldo Ceara, uma parceria com a Universidade Aberta do Brasil, no semestre 2008.2. Utilizou-se como metodo de pesquisa o etnografico e os principios da etnografia virtual. Os dados consistiram das mensagens registradas no forum do ambiente, entrevistas com os alunos e observacoes nos encontros presenciais. Os resultados apontaram os seguintes elementos formadores de uma CVA: Status, Papeis, Normas, Interacao Social e Tecnologias de Informacao e Comunicacao(TIC), validando os elementos formadores de uma comunidade encontrados na literatura e elencando outros elementos, manifestados especificamente nos espacos formais e aprendizagem. Abstract: This study investigated the formation of learning virtual communities (CVA). The research was performed with 18 3rd semester undergrad students in semi-presential mode at Languages –Portuguesein theFederal University of Ceara, a partnership with the Open University of Brazil (Universidade Aberta do Brasil), on semester 2008.2. The ethnographic method was chosen along with the principles of virtual ethnography. The data consisted of messages posted in the forumenvironment, interviews with the students and observations in the presential meetings. The results pointed out the following as composing elements of a CVA: Status, roles, Regulations, Social Interaction and Communication and Information Technologies (TIC), that validated the roles which were already found in literature and made it possible to expose some others that hadn’t been proposed yet. These roles were specifically manifested in formal spaces of learning.
|
2022-02-08T08:54:26.417Z
|
11,069,366 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10903120190940100",
"MAG": "1213724303",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective. To compare the success rates, complication rates, and times required for paramedic students to perform saphenous vein cutdown and adult intraosseous infusion using the bone injection gun (BIG). Methods. This was a prospective, randomized crossover study of 13 senior-level students in a baccalaureate degree paramedic program. Study subjects were instructed in adult intraosseous and saphenous vein cutdown techniques through lecture and laboratory exercises and then randomized into two groups. Group 1 performed saphenous vein cutdown at the ankle, followed by intraosseous infusion using the BIG. Group 2 performed the same procedures but in reverse order. All procedures were performed on preserved cadavers and videotaped. Using a standardized scoring sheet, the authors evaluated the study subjects at the time of the procedures to determine success rates, errors, and complications. Videotapes were later reviewed to verify the time required to complete the procedures. Results. The normalized mean procedure scores were 96.15 (SD 4.28) and 83.83 (SD 15.52) for the intraosseous infusion and saphenous vein cutdown procedures, respectively (95% CI for difference in means, −12.34 to −1.3; p = 0.020). Success rates for establishing venous access were higher for the intraosseous route (92.3%) than the cutdown technique (69.2%), but did not achieve statistical significance (p = 0.250). The times required to initiate fluid flow were 3.91 minutes (SD 0.82) by the intraosseous route and 7.57 minutes (SD 1.80) by venous cutdown (95% CI for difference in means, 2.43 to 5.55; p = 0.000). One critical error and 11 noncritical errors were encountered during the intraosseous procedure, compared with ten critical errors and 29 noncritical errors during the cutdown procedure ( p = 0.195). Conclusion. In a group of inexperienced paramedic students working on a preserved human cadaver model, intravenous access was gained more rapidly, with a higher success rate, and with fewer complications using the bone injection gun than by the saphenous vein cutdown procedure. Further study is needed to evaluate these procedures in the field setting and to compare their feasibility with other alternative venous access techniques such as femoral, external jugular, and central venous cannulation.
|
2022-12-03T13:49:43.909Z
|
13,907,134 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1152/JAPPLPHYSIOL.01300.2003",
"MAG": "2029792174",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Using the forced oscillation technique, we tracked airway resistance continuously during quiet breathing (QB) and deep inspiration (DI), thus observing fluctuations in resistance that may reflect mechanisms of airway stretch and renarrowing. After DI, however, the resistance may be depressed for a period not related to volume changes. We hypothesized that this gradual increase in resistance after DI-induced dilation was determined by a simple time constant. Furthermore, to the extent that this effect reflects dynamic characteristics of airway renarrowing, the resistance change after each tidal inspiration should also be constrained by this temporal limit. A model relating resistance fluctuations to the breathing pattern, including both instantaneous and delayed effects, was developed and applied to data from 14 nonasthmatic and 17 asthmatic subjects (forced expiratory volume in 1 s = 103 +/- 13 and 83 +/- 12%, respectively, means +/- SD) after methacholine challenge (dose 145 +/- 80 and 3.0 +/- 3.4 micromol, respectively) that resulted in respective forced expiratory volume in 1 s reductions of 16 +/- 7 and 24 +/- 6% from baseline. Resistance was measured continuously for 1 min of QB, a DI, followed by a further minute of QB. Resistance values at end expiration (Ree) and end inspiration were calculated. We found that the sequence of Ree after DI was best modeled by a power-law function of time rather than an exponential decay (r2 = 0.82 +/- 0.18 compared with 0.63 +/- 0.16; P < 0.01). Furthermore, the coefficient characterizing this "renarrowing function" was close to equal to the coefficient characterizing the equivalent function of resistance change between each resistance value at end inpiration and subsequent Ree during QB, particularly in the nonasthmatic subjects for whom the intraclass correlation was 0.66. This suggests that the same time-dependent factors determine renarrowing after both large and small breaths.
|
2022-12-15T03:04:11.843Z
|
9,094,329 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/MSR.2015.21",
"MAG": "2066709420",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Over the past decade, both open source and commercial software projects have adopted contemporary peer code review practices as a quality control mechanism. Prior research has shown that developers spend a large amount of time and effort performing code reviews. Therefore, identifying factors that lead to useful code reviews can benefit projects by increasing code review effectiveness and quality. In a three-stage mixed research study, we qualitatively investigated what aspects of code reviews make them useful to developers, used our findings to build and verify a classification model that can distinguish between useful and not useful code review feedback, and finally we used this classifier to classify review comments enabling us to empirically investigate factors that lead to more effective code review feedback. In total, we analyzed 1.5 millions review comments from five Microsoft projects and uncovered many factors that affect the usefulness of review feedback. For example, we found that the proportion of useful comments made by a reviewer increases dramatically in the first year that he or she is at Microsoft but tends to plateau afterwards. In contrast, we found that the more files that are in a change, the lower the proportion of comments in the code review that will be of value to the author of the change. Based on our findings, we provide recommendations for practitioners to improve effectiveness of code reviews.
|
2022-12-27T16:56:24.872Z
|
75,472,796 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/TGR.0b013e31827ea7e4",
"MAG": "2320991142",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objectives: To compare and investigate the relationships between Q-angle values and measures of pain, muscular, and functional performances. Methods: Measures of Q-angles, pain, and muscular and functional performances were obtained in 30 elderly women with bilateral knee osteoarthritis. Pearson correlation coefficients were employed to evaluate relationships between the assessed variables (P < .05). Results: Lower Q-angle values were found in the most symptomatic knee, but no statistically significant correlations were found between the Q-angle and the other evaluated measures. Conclusions: Lower Q-angle values were found on the most symptomatic knee and they were not associated with pain, muscular, or functional performance.
|
2022-02-11T07:18:48.868Z
|
244,340,067 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.32782/2224-6282/171-8",
"MAG": "3203936234",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://prostir.pdaba.dp.ua/index.php/journal/article/download/919/890"
}
|
The purpose of the article is to study pricing strategies and develop measures to improve the pricing strategy of foreign economic activity on enterprises. Pricing strategy is one of the most important components of the entire enterprise management system, which can affect the main performance indicators of the enterprise. It is a plan for the formation and management of prices in order to remain competitive in the market and achieve the goals and objectives. The implementation of an effective pricing strategy is due to the need to make important pricing decisions in the long run that have an impact on the enterprise. The pricing strategy with a foreign economic orientation becomes especially decisive. In the context of export-import operations, it is important for Ukrainian enterprises, as subjects of foreign economic activity, to plan activities for the long term in order to remain competitive in the foreign market. Foreign economic activity of the enterprise creates the preconditions for its sustainable economic development through the expansion of its activities in international markets and the formation of new sources of income production resources, technologies and modern organization of production. Today in the field of pricing there are many problems that reduce both the efficiency of the economy and the effectiveness of pricing policy enterprises in particular. This necessitates a new approach to formation of the company’s pricing policy and formation of its pricing strategy. The following methods are used in the article: analysis and synthesis, generalization, coefficient and graphical method, comparison method and systematization methods. The result of the study is the formation of ways to solve existing problems in Ukrainian enterprises through introducing the price discounts accumulative system and implementing a combined strategy for the formation of export prices to increase efficiency of the enterprise foreign economic activity. The practical significance of the work lies in the developed measures to address the problems of pricing strategy, which were identified at the enterprises of Ukraine, engaged in foreign economic activity.
|
2022-01-27T04:31:01.773Z
|
195,763,472 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4097/kja.19248",
"MAG": "2956110667",
"PubMedCentral": "6900418"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://ekja.org/upload/pdf/kja-19248.pdf"
}
|
ing procedure with a variably reported complication rate [1]. The most commonly reported complications are loss of airway and hemorrhage. Distorted neck anatomy is the most common risk factor for these complications. To perform percutaneous tracheostomy, various adjuncts such as a lightwand, fibreoptic bronchoscopy (FOB), and ultrasound have been reported to help visualize the needle puncture and tracheal tube. However, in ST, the trachea is usually identified using anatomical landmarks, without the help of adjuncts. Here we discuss a case of ST in which FOB was used to visualize the tracheal ring in the presence of distorted neck anatomy. Informed consent has been taken from the patient prior to publication for usage of data and pictures. A 58-year-old man, diagnosed with papillary carcinoma of the thyroid, with history of multiple surgeries and radiotherapy, presented with collapse Letter to the Editor
|
2022-02-08T07:38:08.738Z
|
94,651,863 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.6116/KJH.2014.29.4.1",
"MAG": "1978727247",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objectives : The root bark of Morus alba L. (Mori Cortex Radidus; MCR) has been traditionally used to reduce heat from the lungs, soothe asthma, and edema and to promote urination. In this study, we investigated the effect of MCR ethanol extract on ovalbumin (OVA)-induced allergic asthma in mice. Methods : Mice were sensitized at day 0, 7 and 14 with 0.2% OVA and then airway challenged at day 21, 23, 25, 27 and 29 to induce allergic asthma. MCR extracts at doses of 50 and 100 ㎎/㎏ body weight (bw) were orally administered during OVA challenge once per a day. The levels of allergic mediators such as histamine, OVA-specific IgE, IFN-γ and IL-4 were measured in the sera of mice by ELISA. The histopathological change of lung tissues was observed with hematoxylin and eosin (H&E) staining. Results : MCR extract significantly decreased not only the serum levels of histamine, OVA-specific IgE, and IL-4 compared with those of OVA control group, but significantly increased the serum level of IFN-γ . In H&E staining, MCR extract inhibited the infiltration of inflammatory cells and bronchiolar damage with epithelial thickening in lung tissues of OVA-induced asthma mice. Conclusions : These results indicate that MCR extract inhibits lung damage by asthma through regulating the allergic immune response, suggesting that MCR may be used as a useful agent for the treatment of allergic asthma.
|
2022-02-10T16:10:43.328Z
|
2,596,813 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5772/26900",
"MAG": "1525001879",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://www.intechopen.com/citation-pdf-url/33016"
}
|
The pathophysiology of Neuropsychiatric SLE (NPSLE) will be described in this chapter. Systemic Lupus Erythematosis (SLE) is a multiorgan and multisystem autoimmune disorder and its pathophysiology may have protean effects on all components of the nervous system. The central (CNS) and peripheral nervous systems (PNS) may be involved in SLE. About 25 % of SLE may begin in childhood and SLE may present both steadily chronic and more episodic neurologic symptoms as well throughout the life span. The presentation of symptoms and clinical signs is a reflection of the location and type of pathophysiology of the disease in which there is chronic inflammation of varied degrees that may wax and wane. The chronic disease process is responsible for making the CNS for example more vulnerable to lowered seizure threshold and episodic seizures despite the ongoing more chronic pathophysiology involving the inflammation of the blood vessels. The disease may exert effects on peripheral nerves and over time accumulated lesions or immune mediated damage may make tissues more susceptible to damage. Chronic inflammation or immune mediated damage or vasculitis of blood vessels or the vascular supply of the nerves may predispose to neuropathy and lead to progressive deterioration in function over time as lesion burden accumulates in the PNS. Similarly, SLE may also damage various end organs that may impact the nervous system once affected. For example, SLE may impact the heart and cardiovascular system or be associated with antiphospholipid antibodies that may contribute to embolic strokes. Other end organs may be affected for example kidney dysfunction or renal failure that may lead to uremic encephalopathy. Having a rash present or palpable purpura and multiorgan involvement may present clinical clues that SLE is the diagnosis along with clinical evidence of multisystem involvement. Other pathophysiology exists as noted below. In these regards, this chapter seeks to characterize the pathophysiology of the major categories of disease and syndromes on the nervous system in SLE. The categorization of the signs and symptoms and overall disease state and pathophysiology and structures involved will relate to how these conditions are ultimately diagnosed and treated.
|
2022-03-04T11:45:32.369Z
|
218,959,376 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3897/phytokeys.146.51342",
"MAG": "3023426562",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://phytokeys.pensoft.net/article/51342/download/pdf/"
}
|
A new species of the Rhododendron (Ericaceae) in subgen. Tsutsusi sect. Tsutsusi from Puding county of Guizhou, China, is described and illustrated. The new species, R. pudingense X.Y. Dai, C.H. Yang & Y.P. Ma, is similar to R. myrsinifolium Ching ex Fang et M. Y. He and R. minutiflorum Hu, but it can be easily distinguished by its length and being pubescent on inner surface of corolla tube, sparse hairs below the middle of filament and the glabrous style.
|
2022-03-25T00:46:41.227Z
|
29,503,546 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/jb.159.3.1063-1064.1984",
"MAG": "1489278839",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc215770?pdf=render"
}
|
We present a correction of the previously reported nucleotide sequence of the Citrobacter freundii trp operon regulatory region. The original sequence analyses were performed with a plasmid designated pCF2. We repeated the cloning of the trp regulatory region of C. freundii and concluded from the determined sequence that a DNA rearrangement had occurred within the leader region of the cloned trp DNA of pCF2. The correct sequence is homologous to the Escherichia coli sequence.
|
2022-08-21T05:35:16.606Z
|
155,019,686 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1467-9957.1991.TB00456.X",
"MAG": "2088700231",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper uses the Collery-Barro equilibrium approach to the gold standard to develop a model of discretionary monetary policy under an international gold standard. Monetary policy is defined in terms of changes in the ratio of the monetary gold stock to the currency stock. This is equivalent to defining discretionary policy actions in terms of deviations from the "rules of the game." Unlike other policy indicators such as gold flows, interest rates, or monetary aggregates, the gold-reserve ratio can be used to generate a quantitative estimate of the impact of a single country's monetary policy on the world price level. Copyright 1991 by Blackwell Publishers Ltd and The Victoria University of Manchester
|
2022-09-08T01:10:32.933Z
|
221,161,397 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/access.2020.3014802",
"MAG": "3047864318",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://ieeexplore.ieee.org/ielx7/6287639/8948470/09160946.pdf"
}
|
In distributed wireless sensor networks (WSNs), TDMA protocols are a widely applied solution when a reliable data-transferring mechanism is in demand. However, to produce a TDMA schedule is not an easy task. During the scheduling, there can be a large number of conflicts due to the nature of radio access, which leads to a waste of operating time and energy. In this paper, we first present and discuss the concept of Topological Ordering, which is based mainly on the local neighborhood size. It is aimed to create an order of scheduling that helps reduce the competition and conflicts. Next, we propose a fast and effective distributed scheduling algorithm using Topological Ordering, called DSTO, to create a collision-free TDMA schedule. This algorithm is promising in terms of reducing running time and message collisions during the scheduling phase, which in turn reduces overall message overhead. At the same time, efficient time slot allocation, which translates to a shorter frame, is guaranteed. We implement DSTO together with two other distributed scheduling algorithms on OPNET Network Modeler and thoroughly analyze the comparative results to prove its validity and effectiveness.
|
2022-12-10T16:40:35.507Z
|
32,277,529 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/JF000192H",
"MAG": "2040152822",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Quantitative structure activity relationships (QSAR) and comparative molecular field analysis (CoMFA) are applied in order to explain the aroma of 46 bell-pepper aroma compounds. Biological activities log(1/c) values are used, where c stands for the detection threshold value of the aroma compound in water. Results of conventional QSAR and CoMFA are both satisfactory in statistical significance and predictive ability. We construct a qualitative model using the graphic features of CoMFA together with the results of "classical" QSAR analysis, which is performed by multiple linear regression. Finally, the human olfactory detection threshold values of excluded pyrazines are successfully predicted. This makes CoMFA and QSAR two important tools for designing new aroma compounds and in elucidating the mechanism of odor-receptor interaction.
|
2022-12-15T02:18:50.928Z
|
12,034,353 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/rheumatology/kev359",
"MAG": "2313206347",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/rheumatology/article-pdf/55/3/470/17389199/kev359.pdf"
}
|
OBJECTIVE
Outcome of JDM is highly heterogeneous. Our objective was to determine clinical and muscle biopsy features associated with poor outcome and response to treatment.
METHODS
Clinical data and muscle biopsy were obtained from a monocentric cohort of 29 patients. Clinical subgroups were defined by latent class model analysis of initial and follow-up parameters. Myopathological features were analysed using validated scores. Capillary loss was determined on reconstructions of transversal sections and assessed in the different age groups to take into account variations of muscle capillarization during post-natal development. Regression models were used to identify initial predictors of therapeutic response.
RESULTS
Two distinct homogeneous subgroups of patients were identified according to clinical severity and pathological findings. The smallest group of patients (7/29) presented with severe JDM. Compared with the other group (22/29), patients had more severe muscle weakness at disease onset, low remission rate at 12 months, frequent subcutaneous limb oedema or gastrointestinal (GI) involvement and higher myopathological scores (capillary dropout, perifascicular necrosis/regeneration, fibres with internal myonuclei and fibrosis subscores). Relevance of capillary dropout to JDM severity was substantiated by age-based analysis, confirming its major role in JDM pathophysiology. Most of these manifestations could be related to vasculopathy (limb oedema, GI involvement, capillary dropout). Furthermore, Childhood Myositis Assessment Scale <34 with either GI involvement or muscle endomysial fibrosis at disease onset were the best predictors of poor response to treatment.
CONCLUSION
Vasculopathy is prominent in severe JDM. Simple criteria can be used at initial evaluation to identify patients requiring a more intensive therapy.
|
2022-12-19T11:41:00.366Z
|
244,912,957 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.52507/2345-1106.2021-2.28",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.52507/2345-1106.2021-2.28"
}
|
In its becoming, the marital couple crosses certain obstacles, the partners can become concerned with the security of the relationship in the future, fidelity and property, attraction and rejection. Conflicts can also arise regarding the self-fulfillment and self-realization of the couple on the one hand and its stability and unity on the other. Emotional manipulation is characterized by the fact that the action of the source is primarily focused on influencing psychological processes and phenomena that are involved in structuring, orienting and supporting the attitudinal and behavioral system of the target. These can be processes in the sphere of perception, thinking, affectivity, motivation, etc. A number of psychic phenomena in the cognitive, emotional and relational spheres can be instrumentalized by the manipulator, with sometimes-spectacular results in determining and controlling human behavior, especially when this method is combined with that of information manipulation.
|
2022-01-27T11:45:12.707Z
|
208,380,829 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/uog.20628",
"MAG": "2979246561",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://obgyn.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/uog.20628"
}
|
(AUROC = 0.92), and t-angle (AUROC = 0.87). The best cut-offs values for these measurements were: lateral indentation angle ≤ 130◦ (Se = 75%, Sp = 96%, LR= 0.21, LR+ = 21, PPV = 83%), lateral indentation depth ≥ 7 mm (Se = 85%, Sp = 78%, LR= 0.06, LR+ = 4.2, PPV = 49%), and t-angle ≤ 40◦ (Se = 65%, Sp = 91%, LR= 0.23, LR+ = 6.4, PPV = 64%). 56 women had no criteria (all = normal/arcuate), 20 had only one criterion (PPV = 10%), 10 had only two criteria (PPV = 50%) and 14 had all the three criteria (PPV = 93%). Conclusions: Lateral indentation depth ≥ 7 mm, lateral indentation angle ≤ 130◦ and t-angle ≤ 40◦ might be used for the diagnosis of t-shaped uterus when there is any suspicious by subjective assessment. We suggest considering 0-1/3 criteria = normal/arcuate, 2/3 criteria = borderline t-shape, and 3/3 criteria = definitely t-shaped uterus.
|
2022-05-11T20:35:52.771Z
|
213,416,419 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5603/fc.2020.0008",
"MAG": "3007525116",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://journals.viamedica.pl/folia_cardiologica/article/download/FC.2020.0008/50298"
}
|
We present the case of a 53-year-old woman with New York Heart Association (NYHA) class III heart failure, despite optimal pharmacological therapy. Her medical history included: myocardial infarction with nonobstructive coronary arteries (MINOCA), heart failure with reduced ejection fraction and quadrantanopia with sensory neuropathy diagnosed as ischaemic stroke. Transthoracic echocardiography showed significant left ventricular hypertrophy with a ‘granular’ myocardial texture, global systolic dysfunction and restrictive mitral filling pattern. Two-dimensional (2D) transthoracic echo strain analysis demonstrated decreased global longitudinal strain with apical sparing, and helped to fit all the pieces of the jigsaw together to reach a consistent clinical diagnosis of cardiac amyloidosis.
|
2022-06-20T12:38:39.125Z
|
11,342,801 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/GEOINFORMATICS.2016.7578966",
"MAG": "2526405546",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
As a critical component of Location-Based Service(LBS), reverse geocoding is the process of converting a coordinate obtained by GPS to a readable street address. With the widespread use of location-aware mobile electronic devices and the extensive application of LBS, the capability of reverse geocoding is in high demand. Meanwhile, with the constantly expanding of spatial data size, the computing quantity of reverse geocoding continues to increase. Based on Global Subdivision Model(GSM), this paper presents an efficient reverse geocoding method named Geohash-based reverse geocoding(GBRG). In GBRG, spatial objects are encoded to Geohash codes which can be used to identify the location of the spatial objects. A key point in this step is encoding spatial line objects and region objects with an adaptive Geohash method. Then the spatial objects near the given coordinate are retrieved by comparing the Geohash codes. In order to make sure that the nearest spatial objects are in the scope of the results retrieved, we use the eight neighborhood for retrieval. PostGIS provides a lot of functions for geometric calculation and we use these functions to determine the spatial relations between the given coordinate and the spatial objects. We carry out some experiments using the data of Beijing, China. The results show that GBRG is of high efficiency with some loss in accuracy which can be ignored without obvious influences.
|
2022-06-30T06:22:10.363Z
|
164,595,063 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3138/chr-023-01-10",
"MAG": "2625664603",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
I was very much interested in Mr. Jefferys' article in the December Canadian Historical Review entitled "History in Motion Pictures." As I was technical adviser on the Canadian end of the picture "Hudson's Bay," it is very gratifying to read his general remarks in connection with this production, but at the same time I do feel that he was being a little lenient. The job of a technical adviser on an historical picture is a curious one. Some people call them the technical directors, but they are definitely not that. The advice they give is sometimes taken, but not often. There are three stock excuses offered for not taking such advice: 1. It won't photograph well; 2. It costs too much; 3. Nobody is going to notice it anyway. I had the pleasure of making three trips to Hollywood in connection with the picture "Hudson's Bay," and on my first two visits I think I was of some use. The first time, I went over the script with Mr. Trotti, who is one of their star writers, and was able to suggest various changes in the part that had already been written, and a few other situations which might help the story. The second time, my job was to choose costumes and props. The picture had been on the fire for a couple of years, but at the last moment everything had to be done in a rush, and so proper costumes and props were not obtainable. I wanted them to use big canoes--properly designed and really made of birch bark, or at least covered with birch bark, but they told me that it would cost at least $700.00 apiece to build them. In Canada they could have been built of real birch bark for about $150.00 apiece. They simply used some sixteen-foot canvas canoes covered with fake birch bark, which they borrowed from M.G.M. They were the same canoes as were used in "Northwest Passage." The toboggans used were made of wood with realistic birch bark painted on them, and I think these were the best props of all. The teepees were also made of fake birch bark. The flintlocks had a curious history. They were originally made in large quantities for the troops of Emperor Halle Selassie, to defend his kingdom against the machine guns of the Italians. When that war was finished, the manufacturers found that they had a great number of these flintlocks on hand, so they sold them in batches to the various movie companies. The snowshoes used were simply some that they had in stock, of a nondescript pattern, unlike any used by Canadian Indians.
|
2022-07-10T03:44:46.056Z
|
41,852,663 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/800195.805958",
"MAG": "2005608841",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://dl.acm.org/doi/pdf/10.1145/800195.805958"
}
|
A computing system is discussed which is aimed at high speed execution of programs written in a problem-oriented language. This computing system has a new machine language. Parallel processing of consecutive instructions and the type of data conversion required for an operation can be easily indicated in the machine language.
PL/I is selected for a problem-oriented source language. The programming system in which a source program is translated into the machine language is analyzed and implemented.
The hardware system which executes the machine language is studied and the system is planned. In the system, the machine language is decoded and executed at high speed by refined operation units. The language-directed computer design technique discussed here is becoming increasingly important.
|
2022-09-02T06:09:56.900Z
|
191,407,696 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/OXARTJ/5.1.3",
"MAG": "2315942085",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The aquiline, beturbaned features that glare out from this Quattrocento bronze medallion (Fig. 1) are not a romantic artist's fanciful image of 'The Oriental Potentate', but an ad vivum likeness of Mehmed II, the Ottoman Sultan whose conquest of Constantinople in 1453 and destruction of the millenium-old Byzantine Empire, earned him at the age of 21 the awesome sobriquet of Fatih, the Conqueror. Yet what prompted a Muslim potentate to invite an Italian medallist to his court in the renascent city of Constantinople, the city that became known as Istanbul, or as Mehmed himself punned "Islambul", "Full of Islam"? Was there not a paradox in a Muslim prince patronising an Italian medallist? If there was, this was not the only paradox surrounding Mehmed the Conqueror. Mehmed was heir to an empire that was far from the homogeneous orthodox Sunni state that his sixteenth-century successors, in their clash with the heterodox Shiite Safavids, wished to promote. In the fifteenth century there were various attempts, most notably Shaykh Badreddin Simavna's popular movement, to minimise the differences between Islam and Christianity. In this period of transition we find members of the Palaeologan house serving as commanders of the Sultan; and Mehmed's long-standing Grand
|
2022-09-13T07:19:43.334Z
|
19,458,920 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/AEM.00589-10",
"MAG": "2056841782",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Magnetotactic bacteria synthesize intracellular magnetosomes comprising membrane-enveloped magnetite crystals within the cell which can be manipulated by a magnetic field. Here, we report the first example of tellurium uptake and crystallization within a magnetotactic bacterial strain, Magnetospirillum magneticum AMB-1. These bacteria independently crystallize tellurium and magnetite within the cell. This is also highly significant as tellurite (TeO32−), an oxyanion of tellurium, is harmful to both prokaryotes and eukaryotes. Additionally, due to its increasing use in high-technology products, tellurium is very precious and commercially desirable. The use of microorganisms to recover such molecules from polluted water has been considered as a promising bioremediation technique. However, cell recovery is a bottleneck in the development of this approach. Recently, using the magnetic property of magnetotactic bacteria and a cell surface modification technology, the magnetic recovery of Cd2+ adsorbed onto the cell surface was reported. Crystallization within the cell enables approximately 70 times more bioaccumulation of the pollutant per cell than cell surface adsorption, while utilizing successful recovery with a magnetic field. This fascinating dual crystallization of magnetite and tellurium by magnetotactic bacteria presents an ideal system for both bioremediation and magnetic recovery of tellurite.
|
2022-11-23T17:49:26.092Z
|
15,156,340 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISIT.2012.6283055",
"MAG": "2011971572",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Belief propagation (BP) is a widely used algorithm for computing the marginal distributions in graphical models. However, in applications involving continuous random variables, the messages themselves are real-valued functions, which leads to significant computational bottlenecks. In this paper, we propose a low complexity method for performing belief propagation for continuous state space problems. Our algorithm, which we refer to as quantized stochastic belief propagation (QSBP), is a randomized variant of BP in which each node only passes stochastically chosen information at each round. The most attractive feature of QSBP is its significant gain in computational and communication efficiencies. In addition, we provide some theoretical guarantees including almost sure convergence and the rate of convergence for the case of tree-structured graphical models.
|
2022-11-18T18:07:44.585Z
|
16,990,394 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1175/1520-0485(2000)030<0512:TIUOEA>2.0.CO;2",
"MAG": "2102901598",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract A high-resolution, numerical study of an idealized western boundary current flow over variable topography is presented, with application to the East Australian Current (EAC). The results indicate that alongshelf topographic variations off Australia’s east coast cause the EAC to accelerate over the narrowing continental shelf near Cape Byron. This acceleration is sufficient to hinder the geostrophic adjustment in the bottom boundary layer (BBL), which would usually cause the EAC-driven BBL to shut down. Consequently, a region of persistent, high bottom stress was established off Cape Byron, which was responsible for driving an upwelling BBL. It is shown that the enhanced vertical mixing, associated with a low Richardson number flow beneath the EAC, reduced the local stratification. Consequently, the Burger number is decreased resulting in a long shutdown timescale of the BBL, which enables a nearshore thermal to be established and maintained. Such fronts are commonly observed in the region. As a p...
|
2022-12-19T00:09:04.225Z
|
128,947,249 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1179/009346909791070772",
"MAG": "2004977855",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Mound ZZl, located on the tip of the peninsular portion of the large lowland Maya site of Nixtun-Ch’ich’ in Petén, Guatemala, was investigated in 2007 during a salvage operation. An axial trench revealed a long sequence of activity in the area, beginning before 1000 B. C. and extending into the early 18th century. Early platform construction was accompanied by feasting and smashing of Middle Preclassic (1000—400 B.C.) pottery in a termination and/or dedication rite. The mound grew through the construction and reconstruction of numerous platforms and structures—and further episodes of termination and dedication—that primarily extended it laterally, rather than vertically. The location of Mound ZZl and its features—reincorporation of Middle Preclassic fill materials; secondary burials; clay figurines; protection by a large wall-ditch complex; pecked plaster symbols; and the presence of a Spanish mission church—suggest that it was a key civic-ceremonial component of the region's sacred landscape for nearly three thousand years.
|
2022-12-17T11:14:13.260Z
|
18,844,693 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICASSP.2016.7471968",
"MAG": "2407857922",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Content-aware image retargeting has attracted substantial research interests in the related research community. However, so far there is still no method can preserve important image contents and structure well without introducing deformation. To address this problem, we propose a Saliency & Structure Preserving Multi-operator (SSPM) method. SSPM classifies images into three categories utilizing SIFT density to improve performance of saliency preservation, helping to mitigate negative influence from center-bias property of most existing saliency detection models. SSPM also employs different principles to improve structure preservation performance, including Earth Mover's Distance (EMD) and Gray-Level Cooccurrence Matrix (GLCM) to get optimal operator sequences for smart content-aware image retargeting. SSPM method not only can well preserve salient contents and structure, but also can greatly improve deformation resilience. Experimental results demonstrated that our method outperforms state-of-art image retargeting methods.
|
2022-12-20T19:03:12.393Z
|
38,465,642 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1053/HE.2000.5983",
"MAG": "2036051374",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Intrahepatic bile ducts (BD) are a critical target of injury in the postischemic liver. Decreased vascular perfusion causes characteristic changes in the morphology of the ductular epithelia including a loss of secondary membrane structures and a decrease in plasma membrane surface area. Using adenosine triphosphate (ATP) depletion of cultured normal rat cholangiocytes (NRC) to model ischemic ducts, the present studies examined the fate of apical membrane proteins to determine whether membrane recycling might contribute to rapid functional recovery. Apical proteins, including γ‐glutamyl transpeptidase (GGT), Na+‐glucose cotransporter (SGLT1), and apically biotinylated proteins, were not shed into the luminal space during ATP depletion. Instead, labeling of surface proteins after ATP depletion showed a significant decrease in GGT and SGLT1, consistent with membrane internalization. Similarly, z‐axis confocal microscopy of biotinylated apical proteins also showed protein internalization. During ATP recovery, SGLT1 transport activity remained profoundly depressed even after 24 hours of recovery, indicating that the function of the internalized apical proteins is not rapidly recovered. These studies suggest that the membrane internalization in ATP‐depleted cholangiocytes is a unidirectional process that contributes to prolonged functional deficits after restoration of normal cellular ATP levels. This sustained decrease in transport capacity may contribute to the development of ductular injury in postischemic livers.
|
2022-12-23T02:13:21.723Z
|
124,618,789 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4135/9781483386874.n191",
"MAG": "2247198494",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
皆さん、組織や個人の仕事成果の違いはどこからくるものだと思いますか。知識や経験などの能力の差によるところが大きいとは思いますが、これを、一人ひとりが持っている〈ゴール・目標〉の違いから説明するのが、今回紹介する〈目標設定理論〉（Goal SettingTheory）です。
|
2022-02-09T18:26:58.751Z
|
23,237,761 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18240/ijo.2017.08.08",
"MAG": "2757513568",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://doi.org/10.18240/ijo.2017.08.08"
}
|
AIM
To assess and compare the diurnal macular choroidal area fluctuation in normal and primary open angle glaucoma (POAG) groups using enhanced depth imaging optical coherence tomography (EDI-OCT).
METHODS
Twenty-eight normal and 27 POAG eyes were enrolled in this study. EDI-OCT was used to measure the macular choroidal area every 3h from 9:00 a.m. to 21:00 p.m.
RESULTS
Significant diurnal fluctuations of macular choroidal area were observed in both normal (P=0.003) and POAG groups (P<0.001). But no significant macular choroidal area difference has been found between the two groups at all the five measurement time-points (512778±166242 vs 455079±207278 µm2, P=0.195 at 9:00 a.m.; 501526±168953 vs 447846±211147 µm2, P=0.245 at 12:00 a.m.; 501982±173158 vs 448024±206653 µm2, P=0.239 at 15:00 p.m.; 508912±174589 vs 457783±207081 µm2, P=0.252 at 18:00 p.m.; 503787±171241 vs 453230±205955 µm2, P=0.274 at 21:00 p.m.; respectively). Furthermore, neither the fluctuation manners nor the change in macular choroidal area between the two adjacent measurement time points showed significant difference between normal and POAG groups (all P>0.05). In the meantime, significant diurnal intraocular pressure fluctuations were also observed in normal and POAG groups (both P<0.001).
CONCLUSION
In diurnal time, the macular choroidal area in both normal and POAG groups fluctuated significantly; moreover, neither the value of macular choroidal area, nor the fluctuation of macular choroidal area in POAG group is significantly different from that in normal group.
|
2022-03-19T18:05:28.922Z
|
110,954,885 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TNS.1974.6498930",
"MAG": "2040586582",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The radiation induced charge trapping at the silicon sapphire interface and its effect on MIS/SOS device performance has been experimentally determined for a total ionizing dose up to 108 rads (Si). These effects were determined by measuring the electrical characteristics of three types of device structures fabricated in SOS material: MIS devices with hardened and unhardened gate insulators, JFET's and diodes. The main emphasis is on the use of novel JFET structures for characterizing the SOS interface by modulating the gate depletion region against the sapphire substrate. Micrographs are also presented which show radiation induced changes in the staining characteristics of angle lapped and stained sections of the SOS interface. The experimental results indicate that positive charge is trapped in the sapphire substrate near the silicon-sapphire interface due to the total ionizing radiation. A model of the radiation induced charge trapping at the silicon sapphire interface is proposed.
|
2022-09-01T18:50:04.310Z
|
234,852,729 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/D13050178",
"MAG": "3156293472",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Underground waters are still one of the most important sources of drinking water for the planet. Moreover, the fauna that inhabits these waters is still little known, even if it could be used as an effective bioindicator. Among cave invertebrates, planarians are strongly suited to be used as a study model to understand adaptations and trophic web features. Here, we show a systematic literature review that aims to investigate the studies done so far on groundwater-dwelling planarians. The research was done using Google Scholar and Web of Science databases. Using the key words “Planarian cave” and “Flatworm Cave” we found 2273 papers that our selection reduced to only 48, providing 113 usable observations on 107 different species of planarians from both groundwaters and springs. Among the most interesting results, it emerged that planarians are at the top of the food chain in two thirds of the reported caves, and in both groundwaters and springs they show a high variability of morphological adaptations to subterranean environments. This is a first attempt to review the phylogeny of the groundwater-dwelling planarias, focusing on the online literature. The paucity of information underlines that scarce attention has been dedicated to these animals. Further revisions, including old papers and books, not available online will be necessary.
|
2022-12-02T11:13:16.310Z
|
145,496,320 |
{
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"ArXiv": null,
"DOI": "10.1017/S0008197314000427",
"MAG": "2142302293",
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}
|
Although English privacy law has developed significantly over the past two decades, it continues to focus almost exclusively on the disclosure of private or confidential information. This article argues that if privacy is to be comprehensively protected, then the importance of physical privacy – which is breached when a person is looked at, listened to or recorded against his or her wishes – must also be recognised. After discussing what physical privacy is and why existing protections for it are inadequate, the author contends that a physical privacy action can, and should, be developed from within English common law.
|
2022-12-04T17:56:15.290Z
|
688,929 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/2338966.2336802",
"MAG": "2050169103",
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},
"license": null,
"status": null,
"url": null
}
|
The pay-as-you-go economic model of cloud computing increases the visibility, traceability, and verifiability of software costs. Application developers must understand how their software uses resources when running in the cloud in order to stay within budgeted costs and/or produce expected profits. Scientific workflows often involve data intensive transactions which may be costly. Business and consumer application developers are likely to be particularly sensitive to costs in order to maximize profits. Verification of economic attributes of cloud applications has only been touched on lightly in the literature to date. Possibilities for cost verification of cloud applications include both static and dynamic analysis. We advocate for increased attention to economic attributes of cloud applications at every level of software development, and we discuss some measurement based approaches to cost verification of applications running in the cloud.
|
2022-12-11T13:04:41.753Z
|
153,386,151 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/JEG/LBU020",
"MAG": "1837436992",
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},
"license": null,
"status": null,
"url": null
}
|
A large and growing informal sector is a major feature of developing countries. This paper analyzes coagglomeration patterns between formal and informal manufacturing enterprises in India. It studies (a) the causes underlying these patterns and (b) the positive externalities, if any, on the entry of new firms. The analysis finds that buyer-supplier and technology linkages explain much of formal-informal coagglomeration. Also, within-industry coagglomeration matters mostly to small- and medium-sized formal firm births. Traditional measures of agglomeration remain important in explaining new industrial activity, whether in the formal or the informal sector.
|
2022-12-19T08:17:20.479Z
|
28,333,379 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/j.0022-0337.1985.49.3.tb01862.x",
"MAG": "2150779165",
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},
"license": null,
"status": null,
"url": null
}
|
This study investigated the organizational characteristics of colleges of dentistry as perceived by their deans, associate deans, and department chairs. Likert's Profile of Organizational Characteristics is used to describe the administrative structures of the colleges on a continuum from exploitive/authoritative through benevolent/authoritative and consultative to participatory. In addition, administrators were asked to evaluate their colleges' effectiveness in adapting to an environment of change. The results indicate a relatively low level of participation in administration in contrast to a high desire for participation, and that administrators believe their colleges are only marginally effective in adapting to change.
|
2022-09-13T03:10:39.951Z
|
164,285,510 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.25057/25005731.511",
"MAG": "2563847269",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Las diferentes politicas colombianas que han surgido durante los ultimos 100 anos han cambiado drasticamente, afectando no solo las obligaciones y derechos de los jovenes sino tambien la construccion conceptual de la definicion de juventud. Esta presenta tres momentos diversos, inicia con una juventud representada en un individuo y actualizandola hasta un sujeto de derechos y deberes. En el presente articulo se analizara la diacronia del concepto juventud en las politicas colombianas y se propondra un cuarto momento.
|
2022-02-08T20:30:49.195Z
|
155,705,472 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7142/IGAKUTOSHOKAN.53.244",
"MAG": "2324950453",
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},
"license": null,
"status": null,
"url": null
}
|
The Social Welfare University Library Conference was inaugurated in 1983 by five university libraries aiming at professional education and research on social welfare. The purpose of establishment was to research and survey academic information on social welfare through cooperation of the affiliated libraries, to contribute to the improvement and development of social welfare research. The first Conference examined common problems and searched for solutions by exchanging information, and attempted joint possession of materials. The Conference shared the work of collecting of increasing amount of materials, edited and issued a comprehensive catalogue of periodicals, made a network of mutual use by issuing a common library card, so implementing mutual utilization. What this conference has implemented is now being executed by libraries all over Japan, because of the development of the projects of National Institute of Informatics and the advance of library systems, and because of change in libraries by utilization of IT. Hence the time has come to reestablish the task of the conference. Since 2000, the conference has been reconsidering concrete daily services including training of practitioners and has exchanged information to develop services of each library. It has been 24 years since the conference was inaugurated. 2, 900, 000 books are now available among all the affiliated libraries. In the future the conference is aiming to open to each community as well as to cooperate with other libraries, and hence be the center of the social welfare world.
|
2022-02-09T01:10:06.805Z
|
23,937,197 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/pros.23033",
"MAG": "1930270875",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Drug repurposing of phentolamine, an α‐adrenoceptor antagonist, as an anticancer agent has been studied in human castration‐resistant prostate cancer (CRPC).
|
2022-08-20T01:29:54.747Z
|
95,112,425 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/PSSA.2211000122",
"MAG": "2002084030",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The mechanical stability of the layer system MoSi2/polysilicon is more critical in the case of silicide formation by rapid thermal annealing compared to conventional tempering. Cosputtering of a stoichiometric Mo/Si mixed layer with a thin film of in-situ deposited fresh and clean silicon on top of the underlying CVD polysilicon sheet is found to be a successful preparation method. It is shown that maximum temperatures between 1050 and 1100 °C are sufficient in order to obtain resistivities well below 100 μΩ cm. These conditions can still be accepted considering the resulting dopant redistribution in implanted layers.
Die mechanische Stabilitat des Schichtsystems MoSi2/Polysilizium ist bezuglich der Silizidbildung durch Kurzzeittemperung (RTA) wesentlich kritischer als bei konventioneller Silizierung. Es wird gezeigt, das alternierendes Cosputtern einer Mo/Si2-Schicht mit stochiometrischer Zusammensetzung mit einer zusatzlich in-situ abgeschiedenen frischen und sauberen Siliziumschicht auf dem darunter liegenden CVD-Polysilizium eine geeignete Praparationsmethode darstellt. Es wird nachgewiesen, das mit Maximaltemperaturen zwischen 1050 und 1100 °C spezifische Widerstande unter 100 μΩ cm sicher erreicht werden konnen. Diese Bedingungen konnen auch hinsichtlich der Dotantenumverteilung in implantierten Bereichen akzeptiert werden.
|
2022-09-10T22:10:34.071Z
|
8,752,975 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1523-5378.1996.tb00036.x",
"MAG": "2141007116",
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},
"license": null,
"status": null,
"url": null
}
|
Background.We used egg passage of bacteria stored in water to evaluate the culturability of the coccoid form of Helicobacter pylori, as a complement to the results obtained from various animal models. Egg passage was performed, as it is a simple, rapid, and well‐characterized old method by which to culture and evaluate culturability of bacteria compared to experiments in animal models. Egg passage has been used in such experiments since 1938 for isolation and growth of, for example, Rickettsiae sp. and Chlamydia sp.
|
2022-09-18T14:06:14.757Z
|
235,523,858 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2991/ABSR.K.210420.015",
"MAG": "3158268148",
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},
"license": null,
"status": null,
"url": null
}
|
This study was conducted to explore the effect of methanolic extract of Veithcia merrillii on mortality time and histopathological changes of Fasciola gigantica in vitro. This study used 25 adult flukes of F. gigantica, divided into five groups: C0 as negative control (0.9% PBS), C1 as positive control (0.024mg/ml albendazole), and treatment groups were P1, P2, and P3 used 10%, 25% and 50% extract, respectively. The observation was carried out every 15 minutes to monitor the motility and mortality of each treatment group. Mortality time of each group was determined by score index and analyzed descriptively. Dead flukes from each group were then prepared for histological examination. The results revealed that 50% of V. merrillii extract (P3) had the same mortality time as C1, where all the flukes died after 30 minutes of treatment. Group P2 had a longer mortality time at 45 minutes and P1 was at 75 minutes. Histopathological observation showed alteration on some organs for C1 and treatment groups, including separation of flukes tegument from parenchyma, vacuolization, and disintegration of testis. From the results it can be concluded that methanolic extract of V. merrillii at 25% and 50% concentration was effective as anthelmintic on F. gigantica in vitro.
|
2022-11-27T23:05:01.684Z
|
36,744,850 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/SW/49.2.319",
"MAG": "1976312228",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
After moving to the Jane Addams College of Social Work at the University of Illinois at Chicago, I have reflected ever more deeply on the innovative work of Jane Addams. Everyday, I walk over the same ground that she walked over. Hull House is only two blocks away from my office. I ponder about her life and how it was she made such an impact on the lives of her poor, immigrant neighbors. I believe Jane Addams recognized that her community approach to helping people was unique. Her speech at the National Conference of Social Work in 1930 indicated that social work's special genius is its closeness to the people it serves (Addams, 1931). How close are today's social workers to the people and communities they serve? More important, I wonder what Jane Addams would be doing to deal with today's urban problems. Would she compare the profession as it existed in 2001 as the one she helped found (Brieland, 1990; Lundblad, 1995)? The social work profession is a legacy of Jane Addams. We trace our roots to her. The work Jane Addams and others like her started in the early settlement houses became mainstream during the 1960s and found its place in the curricula of schools of social work. Aspects of community practice (for example, community organization, development, planning, and administration) have become essential elements of higher education in social work. What is my concern? Many groups outside the social work profession are doing important work in community practice. These include the National Community Building Network (NCBN) and the U.S. Department of Housing and Urban Development (HUD). For at least two decades there have been training institutes for community organizers outside of social work. However, little attention was paid by the outsiders to what was going on in social work. Current initiatives are different, with widespread interest outside of social work, and in one case focused on community organization as taught and practiced in social work. In addition, groups within social work are working to bring a community practice perspective to the forefront. These include two national organizations, the American Humane Association (AHA) and the Alliance for Children and Families (ACF). I am concerned that, as an organized group of social work practitioners and educators, we are not at the table (or barely at the table) as these new articulations of community practice are forming. Allow me to cite a few examples of formally organized groups that are developing innovative practice models. Within each group are committees or small groups focusing on curriculum development. Community Practice Organizations National Community Building Network NCBN provides a forum for community practitioners, researchers, funders and others engaged in neighborhood transformation to share their common interests, insights into barriers they encounter, and field-tested strategies for rebuilding communities. The network is also committed to developing tools and building capacity within communities to influence comprehensive community-building policies at the local, state, and federal levels. For example, the Social Action and Policy Development Continuum is a framework for collecting and developing the curriculum and tools needed to support all phases of social action and policy development (http://www.ncbn.org). HUD's Office of University Partnerships (OUP) Established in 1994, OUP is a catalyst for joining colleges and universities with their communities in a shared search for answers to pressing urban problems. In August 2000, HUD announced $7.5 million in grants to 24 colleges and universities "to help harness their physical and economic resources--and the knowledge, creativity, and energy of their faculty and students--to create stronger, healthier neighborhoods near their campuses" (OUP, 2000a, p.1). With support from the Rockefeller Foundation and the University of Memphis, those involved in the HUD-funded Community Outreach Partnership Centers (COPC) projects have organized a new national nonprofit association. …
|
2022-12-17T06:32:23.485Z
|
72,950,261 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5807/KJOHN.2013.22.3.208",
"MAG": "2142023228",
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},
"license": null,
"status": null,
"url": null
}
|
【Purpose: This study is a correlative study to assess the relationships of fatigue, stress, and burnout among the pregnant nurses in hospital. Methods: The subjects in this study were 103 nurses aged between 22 and 40 who were confirmed as pregnant by the OBGY (Obstetrics and Gynecology) hospital and working at medical facilities located in J-province of G city during the period of July 15 through September 15, 2010. Results: The level of fatigue of pregnant nurses showed an average of 5.60 out of 10 points, and the level of stress showed an average of 25.91. In terms of burnout, the average was 2.72 out of 5 points. The results of the correlative study to assess relationships among fatigue, stress and burnout showed significant positive correlation between burnout and fatigue (r=.47, p】
|
2022-09-12T11:38:01.018Z
|
237,273,669 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1101/2021.08.18.21262201",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GREEN",
"url": "https://www.medrxiv.org/content/medrxiv/early/2021/08/24/2021.08.18.21262201.full.pdf"
}
|
The isothermal molecular diagnosis with CRISPR has attracted particular interest for the sensitive, specific detection of nucleic acids. However, most of the assays with Cas enzymes were performed in bulk assays using multistep approaches and hard to realize quantitative detection. Herein, we report Microfluidics-Enabled Digital Isothermal Cas13a Assay (MEDICA), a digital format of SHERLOCK with enhanced robustness and sensitivity. We first address the macromolecular crowding problems when combining the recombinase polymerase amplification (RPA) and Cas13a detection into a one-pot SHERLOCK assay. After the assay optimization, the enhanced one-pot SHERLOCK (E-SHERLOCK) achieves high robustness and 200-fold increased sensitivity. Leveraging droplet microfluidics, we streamline the E-SHERLOCK to eliminate undesired input targets caused by pre-amplification before partition, enabling background-free absolute quantification. From the real-time monitoring, MEDICA enables qualitative detection within 10 min and absolute quantification within 25 min. For the proof of concept, we applied MEDICA to quantify HPV 16 and 18 viral loads in 44 clinical samples, indicating perfect accordance with qPCR results. MEDICA highlights the CRISPR-based isothermal assays are promising for the next generation of point-of-care diagnostics.
|
2022-02-07T20:49:01.032Z
|
14,445,463 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/LCOMM.2007.060824",
"MAG": "2171129815",
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},
"license": null,
"status": null,
"url": null
}
|
A novel scheduling scheme for local area wavelength division multiplexing (WDM) single hop networks is introduced. The proposed protocol provides pre-transmission coordination schedule without collisions. It is based on a broadcast and select star architecture and uses a timeslot based access protocol. The proposed scheme incorporates a prediction based system, in order to reduce the amount of time spend in computing the schedule by predicting traffic requests. A series of simulation results is presented which indicates that when a specific schedule order is followed, starting from the node with the greatest demand, and completing to the node with the least demand (in transmission time) then a better network performance is achieved. Furthermore, the network throughput is higher, while the mean time packet delay at the waiting queues seems to be lower
|
2022-02-13T02:43:33.175Z
|
206,962,208 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/gutjnl-2015-309714",
"MAG": "1908798151",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Whereas the intestinal epithelium self-renews every 3–5 days, it promotes a robust antimicrobial response to enteropathogens when they first breach the integrity of the mucosal barrier. Foremost, the interaction between gut commensals and the single layer of intestinal epithelial cells is involved in many common, essential physiological processes (eg, nutrient absorption, cell proliferation, cell motility and metabolic activities). In Crohn's disease, it is thought that impaired epithelial function develops into transmural inflammatory lesions at the terminal ileum, where abnormal granule formation and enhanced necroptosis of Paneth cells are frequently observed. Located at the base of the crypt of Lieberkuhn in the small intestine, Paneth cells are one of the four major epithelial cell lineages, which play an essential role in maintaining the resistance of epithelial surfaces to microbial colonisation. Accordingly, genome-wide association studies have revealed a large set of inborn genetic errors in several regulatory factors involved in the maintenance of Paneth cell function.1 However, it is still not clear whether impaired secretory function of Paneth cell precedes the onset and relapse of Crohn's disease. In this context, it is essential to gain an understanding of the exact …
|
2022-07-19T02:53:30.856Z
|
8,966,582 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11113/JT.V46.281",
"MAG": "2055157447",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Previous work done in the extraction of phenol from oil palm shells showed that it contained up to 80.1% purity of phenolic compounds. The oil-palm-shell-based phenol is applicable to replace petroleum-based phenol in preparation of phenol formaldehyde wood adhesives. Since the average price of petroleum-based phenol is around RM 3600/ton, this work was done to estimate the cost of oil-palm-shell-based phenol. In this present research, three oil-palm-shell-based phenol manufacturing plants were investigated. Their manufacturing capacities are 1000 ton/year, 10 000 ton/year, and 100 000 ton/year. All the designs are based on the results from simulator DESIGN II. From the economic analysis, the cost of the oil-palm-shell-based phenol is RM 1084, RM 1008, and RM 972 per ton respectively. It shows that the cost of the oil-palm-shell-based phenol is reduced when the productivity is high. The net profit after taxes for these plants is RM 361,530, RM 4,140,764 and RM 43,943,092 per year respectively. The plants require 3 years for starting-up and their operating life is 17 years with a depreciation of 10% per year. For undiscounted cash flow, the pay back period is 10.0, 8.4, and 7.8 years respectively including the first 3 years. For different discount rates, values of net present value and discounted break-even point vary. The discounted cash flow rate of return is 14.0%, 20.0%, and 25.0% respectively in these plants with related net present value becomes zero. The after tax rate return obtained are 71%, 169%, and 426% respectively.
|
2022-09-08T06:11:04.319Z
|
211,379,395 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/ijm-10-2018-0345",
"MAG": "2978873131",
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},
"license": null,
"status": "GREEN",
"url": "http://ray.yorksj.ac.uk/id/eprint/3983/3/manuscript%20190228.pdf"
}
|
Purpose
The purpose of this paper is to examine the instrumental use of social capital regarding career growth within an organization, focusing on the mediating role of perceived competence mobilization and the moderating role of two situational variables: perceived external prestige and job insecurity climate.
Design/methodology/approach
Relationships among the constructs are predicted based on relevant literature, and are tested using survey results from 324 employees working in 14 leading corporations in Korea.
Findings
Results show that social capital positively influenced, via perceived competence mobilization, each of two career growth dimensions (i.e. the personal efforts to develop a career and the experience of being rewarded by the organization). In contrast, moderated path analysis indicated that perceptions of external prestige and job insecurity climate failed to moderate the indirect effect of social capital on career growth.
Practical implications
In light of the instrumental use of social capital and the ensuring mechanism of competence mobilization, a detailed understanding of this effect on career growth cannot only neutralize the fears of brain drain, but is also helpful in providing possibilities for building new career development strategies.
Originality/value
Although social capital has become an influential concept in social sciences, little evidence has been presented on the above relationship, particularly from the perspective of careerist orientation. This may be the first research examining how and when the influence of social capital becomes instrumental with respect to career attainment within an organization.
|
2022-09-12T13:15:06.189Z
|