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{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.7748/ns.31.39.11.s12", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
Nurses who have dementia should be allowed to continue working, congress resolved.
2022-02-12T14:33:02.275Z
23,860,144
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/FIE.2008.4720563", "MAG": "2142007958", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The process of receiving and using feedback from teachers and peer editing groups in the writing classroom, while valuable, is not sufficient in the discipline of technical communication. Technical communication relies heavily on experiential learning, which is typically gained through internships and coops. Similarly, in courses with a service-learning component or activities, students are able to interact with real-world audiences, getting feedback on their work from audiences beyond the classroom. There has been little integration of service learning into technical communication courses serving a student population comprised of engineering students. In courses with this type of curricular structure, students have the opportunity to learn and apply writing, editing, and collaboration strategies specific to the field of engineering in non academic situations. This paper outlines the justification and methodology for using community engagement and service learning assignments in technical writing courses that primarily serve students in engineering programs. It outlines the benefits to the students and community organizations; details how I, while at the University of Alaska Anchorage, used service learning as a means of programmatic assessment in my technical communication courses; and concludes with the methods of assessment used to evaluate the effectiveness of this type of course.
2022-02-12T19:03:40.259Z
90,806,265
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.7124/bc.000939", "MAG": "2584373471", "PubMedCentral": null }, "license": "CCBY", "status": "GOLD", "url": "http://www.biopolymers.org.ua/pdf/en/32/6/418/biopolym.cell-2016-32-6-418-en.pdf" }
M. S. Chesnokov, O. M. Krivtsova, P. A. Skovorodnikova © 2016 M. S. Chesnokov et al.; Published by the Institute of Molecular Biology and Genetics, NAS of Ukraine on behalf of Biopolymers and Cell. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited UDC 57.032
2022-02-10T18:40:45.042Z
78,728,974
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5334/IJIC.2869", "MAG": "2580839007", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Introduction : Every governmental health institution in Italy implements its strategic annual plan though a balance score card system (BSC). The ASL (Azienda Sanitaria Locale) of Viterbo that coordinates the entire Viterbo province health system, including several hospitals, primary care districts, home care, veterinary activity, hygiene, vaccination, prevention and food and water control, is using a BSC tool to implement its strategic plan. The BSCs with specific targets and objectives are set at the beginning of the year. They are discussed and negotiated with each director of the 102 Operative Units (O.U.) within the ASL of Viterbo. Each director of the O.U after signing the commitment contract will try to reach or realize the single targets and objective. Most of them up today are used to work in an individual way and they want to be judged at the end of the year as “single” players instead on how they are performing as “team” players. Objective : The aim of our study was to plan an integrated care system using the existing BSC system and monitor the integration level between the shared objectives and O.U. through a social network analysis to validate and estimate the integrated care level within the ASL system before signing the BSC. The final goal was indeed the improvement of healthcare performance at regional and national level. Methods : Instead giving “single” player objectives to the directors of the O.U. we set shared goals that will require a “team play” integrated approach to reach the final goal. The same objectives were indeed given to all the O.U. involved in the process. We focus the measure on the results of a good team work between the players. We extracted data and goals from governmental national and regional performance evaluation system for regional healthcare system. Subsequently we choose critical areas of intervention where integrated care was highly needed through a need assessment analysis. The same goals were sets to different O.U. with the recommendation to collaborate with the other linked O.U. in the process. To obtain a big picture of integration of care between the different O.U. before releasing the final BSCs we used the Social network analysis (SNA). The SNA was set as a bimodal network between O.U. and objectives, that were linking the O.U. together. We used the “island method” and the statistical metrics to evaluate the integration and the clustering effect. Results : The clustering analysis of the SNA permitted us to understand the real functional teams that were different form the formal organizational structure. The cluster indeed reflect a functional structure that was invisible before. This allowed to redistribute the resources between the O.U. in a different way using the functional clusters. The SNA statistical metrics permitted to understand which O.U. were the crossroads between functional clusters using the betweenness centrality but also which O.U. had a more controlling activity of the process using the Eigenvector centrality and the closeness centrality. Conclusions : The SNA was an effective support tool to draw an effective integrated care plan but it was also useful to plan a strategic deployment of objectives and resources. The shared goals on the balance score forced the directors to meet and prepare integrated strategic plans to respond to the issue. The final integrated care effects were visible through the improvements on several regional and national indicators.
2022-06-18T20:39:35.870Z
21,605,254
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1519/JSC.0b013e31815f2f42", "MAG": "2092641290", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The purpose of this study was to determine the accuracy of the pedometer when walking, skipping, galloping, sliding, and hopping. One hundred-two college students were fitted with a pedometer (Walk4Life LS-7010) at mid-thigh on the right and left of the hip. Participants then performed the randomly assigned movements for the length (26 m) of a hardwood court playing surface, during which time the investigator tallied the steps with a hand counter. Each step with the lead foot elicited a tally on the counter. Participants were instructed to perform the movement at a brisk pace, to jump-stop at the end of the court, and to remain still until after the pedometer reading was recorded. Repeated measure ANOVAs using the Bonferroni technique were used to compare differences between pedometer counts and hand counts. Significant differences were evident between the hand tally counts and readings from the right and left pedometers during all five locomotor movements (P < .01). Mean error was lowest between the hand tally and the average of the right and left pedometers while walking (−1.35 ± 1.60) and hopping (−2.94 ± 2.33), and increased while sliding (−6.42 ± 4.78), galloping (−8.22 ± 4.63), and skipping (−8.30 ± 4.45). Results indicate the pedometer may not consistently register the vertical force produced by the trail foot contact, the lead foot contact, or a combination of the two while skipping, galloping, and sliding. Though the pedometer is a valid instrument when estimating physical activity levels, caution is urged when interpreting movements other than walking.
2022-09-08T02:54:12.555Z
26,540,173
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1088/1367-2630/9/8/291", "MAG": "2070866898", "PubMedCentral": null }, "license": "CCBY", "status": "GOLD", "url": "https://doi.org/10.1088/1367-2630/9/8/291" }
It is thought that the small-scale magnetic fields observed in accretion discs, galaxies and galactic clusters are generated by a dynamo process in which the turbulent plasma amplifies small initial magnetic fluctuations. Numerical simulations of turbulence have revealed that turbulence consists of filament-like vortex structures superimposed on an incoherent background, which carry a considerable amount of the energy. The natural questions to ask are whether these coherent structures can generate a magnetic field and, if so, if the generated magnetic field is also filament-like. After setting up a turbulence model which consists only of vortex filaments, we show in an unambiguous way that the coherent structure can sustain kinematic dynamo action and that the magnetic field thus generated consists of relatively thick ribbons (flattened tubes) located in between vortices.
2022-09-09T05:03:16.236Z
7,285,019
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1089/jpm.2015.0150", "MAG": "2124542079", "PubMedCentral": null }, "license": null, "status": null, "url": null }
BACKGROUND The psychological well-being of siblings of children with life threatening illness remains largely uncharted. Pediatric cancer research suggests that a supportive family environment may protect the psychological well-being of siblings. OBJECTIVE We hypothesized that (1) siblings of pediatric palliative care patients would show clinical/behavioral scores that were elevated but that rates of serious psychopathology would be comparable to the general population of children their age; and (2) higher family functioning scores would be associated with lower clinical scores and higher adaptive scores for these siblings. METHODS We conducted an observational study with families in which a patient receiving palliative care had one or more siblings between the ages of 6 and 11. Parents completed the Behavioral Assessment System for Children, Second Edition (BASC-2) to assess the siblings' psychological well-being and the Family Assessment Device (FAD) to assess the family environment. RESULTS Twenty-four parents reported data for 30 siblings. Only three siblings scored in the clinical range on a BASC-2 composite clinical scale, and 11 siblings scored in the at-risk range on one or more composite scales. Higher FAD scores predicted significantly higher externalization composite clinical scores (7.54, 95% CI: 1.12, 13.97, p < 0.05) and significantly higher behavioral composite scores (7.88, 95% CI: 1.55, 14.21, p < 0.05). DISCUSSION Siblings of pediatric palliative care patients are not experiencing lower psychological well-being than the general population. The prediction that a positive family environment would be associated with higher levels of psychological health was supported.
2022-12-21T09:24:50.584Z
22,595,323
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/sim.3935", "MAG": "2133927164", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Confounder‐adjusted estimates of the risk difference are often difficult to obtain by direct regression adjustment. Estimates can be obtained from a propensity score‐based method using inverse probability‐of‐exposure weights to balance groups defined by exposure status with respect to confounders. Simulation was used to evaluate the performance of this method. The simulation model incorporated a binary confounder and a normally distributed confounder into logistic models of exposure status, and disease status conditional on exposure status. Data were generated for combinations of values of several design parameters, including the odds ratio relating each of the confounders to exposure status, the odds ratio relating each of the confounders to disease status and the total sample size. For most design parameter combinations (474 of 486), the absolute bias in the estimated risk difference was less than 1 percentage point, and it was never greater than 3 percentage points. The confidence interval generally had close to nominal 95 per cent coverage, but was prone to poor coverage levels (as low as 78.5 per cent) when both the confounder‐to‐exposure and confounder‐to‐outcome odds ratios were 5, consistent with strong confounding. The simulation results showed that the conditions that are favourable for good performance of the weighting method are: reasonable overlap in the propensity score distributions of the exposed and non‐exposed groups and a large sample size. Copyright © 2010 John Wiley & Sons, Ltd.
2022-12-25T13:56:49.035Z
141,936,189
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5860/choice.41-2458", "MAG": "594954804", "PubMedCentral": null }, "license": null, "status": null, "url": null }
1. Principles of Restorative Justice John Braithwaite 2. Specifying Aims and Limits for Restorative Justice: A 'Making Amends' Model? Andrew von Hirsch,Andrew Ashworth and Clifford Shearing 3. Restoration and Retribution Antony Duff 4. Imposing Restoration Instead of Inflicting Pain Lode Walgrave 5. Some Sociological Reflections on Restorative Justice Anthony Bottoms 6. Restoration and Retribution in International Criminal Justice: An Exploratory Analysis Paul Roberts 7. Towards a Systemic Model of Restorative Justice Jim Dignan 8. Proposed Basic Principles on the Use of Restorative Justice: Recognising the Aims and Limits of Restorative Justice Daniel Van Ness 9. Victims and Offenders Barbara Hudson 10. Restorative Justice and Criminal Justice: Just Responses to Crime? Joanna Shapland 11. Mind the Gap: Restorative Justice in Theory and Practice Kathleen Daly 12. Restorative Justice in Canada: From Sentencing Circles to Sentencing Principles Julian V Roberts and Kent Roach 13. Restorative Justice in New Zealand Allison Morris and Gabrielle Maxwell 14. New, Improved Police-Led Restorative Justice? Richard Young and Carolyn Hoyle 15. Evaluating Restorative Justice Practices Leena Kurki 16. Models, Challenges and The Promise of Restorative Conferencing Strategies Mara Schiff Index
2022-12-28T18:31:58.882Z
30,307,391
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1137/S0895479894274541", "MAG": "1986995983", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The polar decomposition of a square matrix is a major step toward the singular value decomposition, and is an important device in its own right. Singular values of a matrix $A$, being the eigenvalues for a matrix closely related to $A$, generally cannot be computed by a finite process if only arithmetic operations and radicals are allowed. However, this consideration alone does not prove that the polar decomposition is not finitely computable. The problem of finite computability of the polar decomposition is not settled in this paper, but we do show it to be equivalent to the following simpler-looking problem. Suppose $f$ is a real polynomial of degree $ n > 4$, and all the roots of $f$ are distinct positive numbers. Denote by $g$ a polynomial of the same degree whose zeros are the positive square roots of the zeros of $f$. Can this polynomial $g$ always be computed finitely for a given polynomial $f$? In the Appendix we discuss one nontrivial situation where the polar decomposition can indeed be computed finitely.
2022-12-31T20:44:18.424Z
219,646,606
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.22481/rg.v4i1.6392", "MAG": "3024570160", "PubMedCentral": null }, "license": "CCBY", "status": "GOLD", "url": "https://periodicos2.uesb.br/index.php/geo/article/download/6392/4763" }
The main objective of this article and its methodological proposals is to carry out environmental analysis based on the integration of natural components and anthropic elements, with responses to changes in the environment delimited over 10 years. For this, the concept of landscape is adopted as a category, which collaborates in the understanding of social and natural relations in a given space, and that through human activities it is possible to observe the physical and anthropic transformations in the lived nature. Cartographic works were carried out using orbital images and through them the NDVI and the visual analysis of the vegetation cover were obtained, showing that the modifying actions had as an essential factor the anthropic action.
2022-02-08T01:32:35.139Z
244,531,735
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/PHM-Nanjing52125.2021.9613119", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
A general description modeling method of Space tracking, telemetry and command (TT&C) system based on system modeling language (SysML) is provided for reliability evaluation. By using SysML diagrams, this paper this paper gives the requirements modeling and behaviors description method. A modeling process for a TT&C mission of satellite launch is illustrated as an example. It shows that SysML model can provide a clear description of TT&C system for reliability modeling.
2022-01-27T05:21:37.021Z
177,386,938
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.4000/BOOKS.IFPO.5062", "MAG": "1507175203", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Webquest Go to each website listed; answer the following questions using the websites. For additional support on vocabulary, open another window and use the dictionary at 1. Who is the owner/author of the website? What might their viewpoint be, and who might their audience be? 2. List the reasons under " Environmental Degradation of the Dead Sea " that the Dead Sea should be saved. 3. Summarize the two issues of sustainable development under the " Peace Conduit " section. 4. What three nations/territories are coming together to make this project happen? 5. What does the website say are the " Consequences of Inaction " 6. Who is the owner/author of the website, and when was the article published? How might this compare to your answer to number 1? 7. Look at the map of the " Dead Sea Region " , what four countries rely on the Gulf of Aqaba? 8. How many inches of water are lost each year in the Dead Sea? Why would this be a significant problem? 9. What does the author believe is the main problem with the canal? 10. What other two-part solution is posed at the end of the article? Do you feel it would be a better option, why or why not?
2022-02-08T14:52:27.261Z
125,707,382
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.4314/SAJG.V6I1.5", "MAG": "2612733999", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Survey measurements have become the traditional means of obtaining point positions by most surveyors over the centuries. The assertion that a post processed DGPS field data is precise, accurate and can be used to execute any engineering works due to its minimum human errors need to be reviewed; this is because the post processed field data still contains errors and needs to be adjust. Adjustments and computations is one of the main research fields in geodesy to assess the magnitude of errors and to study their distributions whether they are within or not within the acceptable tolerance. In order to achieve the objective of this study, a DGPS field data was adjusted using the Ordinary Least Square (OLS) and Total Least Square (TLS) techniques. The OLS considers errors only in the observation matrix, and adjusts observations in order to make the sum of its residuals minimum. The TLS considers errors in both the observation matrix and the data matrix, thereby minimizing the errors in both matrices. The limited availability of information on TLS in adjusting DGPS field data and the uncertainty of which method is optimal, whether the OLS and TLS is the most appropriate technique has called for the need to undertake this study. This study aimed at comparing the working efficiency of the OLS and TLS, assessing their individual accuracy and selecting the most effective method in adjusting DGPS field data. After applying the OLS and TLS methods independently for the same datasets, it was ascertained that, the OLS method was better in adjusting DGPS field data than the TLS in this study, though both methods were closely related.
2022-09-01T04:49:48.823Z
96,982,304
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1039/F19898500999", "MAG": "2071767934", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Amorphous Pd1Zr2 has been used as a precursor for the preparation of CO2 hydrogenation catalysts. The active catalysts were obtained by exposing the amorphous alloy to CO2 hydrogenation conditions. During this exposure the bulk and surface structure of the alloy changed drastically. The most important changes were: (i) partial crystallization of the amorphous alloy; (ii) the formation of palladium metal particles; and (iii) the oxidation of zirconium to zirconium dioxide. These changes were accompanied by an increase in both the B.E.T. surface area and the palladium surface area of more than two orders of magnitude. Palladium was found to exist in two discernible phases, as pure metal and as solid solution with hydrogen. Two types of palladium particles were distinguishable, small disordered particles and larger crystalline particles of ca. 12 nm mean size. The catalytic behaviour of such catalysts was compared with the corresponding behaviour of a Pd/ZrO2 catalyst prepared by wet impregnation of crystalline zirconia with a palladium salt. The activity and selectivity behaviours of the two catalyst types were largely different. Palladium contained in the catalyst derived from amorphous Pd1Zr2 was more than an order of magnitude more active for CO2 conversion than palladium in the catalyst prepared by wet impregnation. Over Pd/ZrO2 derived from Pd1Zr2 the products were metane, methanol amd CO, whereas over the conventionally prepared Pd/ZrO2 no substantial methanol formation was observed.
2022-09-23T17:49:46.272Z
98,147,681
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/CRAT.200610748", "MAG": "2091906766", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Effects of substrate temperature and atmosphere on the electrical and optical properties of Ga‐doped ZnO thin films deposited by rf magnetron sputtering were investigated. The electrical resistivity of Ga‐doped ZnO (GZO) films decreases as the substrate temperature increases from room temperature to 300°C. A minimum resistivity of 3.3 × 10–4 Ω cm is obtained at 300°C and then the resistivity increases with a further increase in the substrate temperature to 400°C. This change in resistivity with the substrate temperature is related to the crystallinity of the GZO film. The resistivity nearly does not change with the O2/Ar flow ratio, R for R < 0.25 but increases rapidly with R for R > 0.25. This change in resistivity with R is also related to crystallinity. The crystallinity is enhanced as R increases, but if the oxygen partial pressure is higher than a certain level (R = 0.25 ± 0.10) gallium oxides precipitate at grain boundaries, which decrease both carrier concentration and mobility. Optical transmittance increases as R increases for R < 0.75. This change in transmittance with R is related to changes in oxygen vacancy concentration and surface roughness with R. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
2022-09-24T03:55:08.150Z
215,948,788
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.21608/ajssa.2018.70410", "MAG": "3006412296", "PubMedCentral": null }, "license": "CCBY", "status": "GOLD", "url": "https://ajssa.journals.ekb.eg/article_70410_1d3d9f71db20d01d4498763d433e16a5.pdf" }
The aim of this research is to make An Educational program according to contribution  Percentage of some kinematic  variables  to  the flat horizontal strike skill as a predictive indication of the accuracy of the technical performance of beginners in field hockey The researchers used the pre and post measurement experimental method for a single experimental group and 3D kinamatic analysis using five high-speed cameras and the Simi Motion Analyses computer program The research sample was chosen in the deliberate random way represented by (8) female players from the first team of field hockey in Sharqia Sporting Club because of their excellence in performing the skill of the flat horizontal strike.   player performed (3) performance attempts for the skill in question, and the best attempt was selected according to the aiming test on the goal, making the number of attempts analyzed and subjected to statistical treatments (8) attempts.
2022-11-04T00:24:00.809Z
17,255,168
{ "externalids": { "ACL": null, "ArXiv": "astro-ph/9802249", "DOI": "10.1086/311282", "MAG": "2952520535", "PubMedCentral": null }, "license": null, "status": "CLOSED", "url": null }
Several classes of stars (most notably O and B main-sequence stars, as well as accreting white dwarfs and neutron stars) rotate quite rapidly, at spin frequencies greater than the typical g-mode frequencies. We discuss how rapid rotation modifies the κ-mechanism excitation and observability of g-mode oscillations. We find that, by affecting the timescale match between the mode period and the thermal time at the driving zone, rapid rotation stabilizes some of the g-modes that are excited in a nonrotating star and, conversely, excites g-modes that are damped in the absence of rotation. The fluid velocities and temperature perturbations are strongly concentrated near the equator for most g-modes in rapidly rotating stars, which means that a favorable viewing angle may be required to observe the pulsations. Moreover, the stability of modes of the same l but different m is affected differently by rotation. We illustrate this by considering g-modes in slowly pulsating B-type stars as a function of the rotation rate.
2022-12-02T10:19:02.571Z
29,833,775
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1021/pr500317d", "MAG": "2325429075", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Multiplexed quantitation is essential for discovering, verifying, and validating biomarkers for risk stratification, disease prognostication, and therapeutic monitoring. The most promising strategy for quantifying unverified protein biomarkers in biofluids relies on selected/multiple reaction monitoring (SRM or MRM) technology with isotopically labeled standards employed within a bottom-up proteomic workflow. Since cerebrospinal fluid (CSF) is an important fluid for studying central nervous system (CNS) related diseases, we sought to develop a rapid, antibody- and fractionation-free MRM-based approach with a complex mixture of peptide standards to quantify a highly multiplexed panel of candidate protein biomarkers in human CSF. Development involved peptide transition optimization, denaturation/digestion protocol evaluation, transition interference screening, and protein quantitation via peptide standard curves. The final method exhibited excellent reproducibility (average coefficient of variation of <1% for retention time and <6% for signal) and breadth of quantitation (130 proteins from 311 interference-free peptides) in a single 43-min run. These proteins are of high-to-low abundance with determined concentrations from 118 μg/mL (serum albumin) to 550 pg/mL (apolipoprotein C-I). Overall, the method consists of the most highly multiplexed and broadest panel of candidate protein biomarkers in human CSF reported thus far and is well suited for subsequent verification studies on patient samples.
2022-12-18T01:16:52.172Z
152,612,351
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.2139/ssrn.821087", "MAG": "2598889997", "PubMedCentral": null }, "license": null, "status": null, "url": null }
This book suggests that the scope and breadth of regulatory reforms since the mid-1980s and particularly during the 1990s, are so striking that they necessitate a reappraisal of current approaches to the study of the politics of regulation. The authors call for the adoption of different and fresh perspectives to examine this area.
2022-12-23T08:24:12.484Z
5,032,501
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1136/bmjopen-2017-020316", "MAG": "2804416226", "PubMedCentral": "5914725" }, "license": null, "status": null, "url": null }
Introduction Delirium, which is prevalent in postcardiac surgical patients, is an acute brain dysfunction characterised by disturbances in attention, awareness and cognition not explained by a pre-existing neurocognitive disorder. The pathophysiology of delirium remains poorly understood. However, basic science and clinical studies suggest that sleep disturbance may be a modifiable risk factor for the development of delirium. Dexmedetomidine is a α-2A adrenergic receptor agonist medication that patterns the activity of various arousal nuclei similar to sleep. A single night-time loading dose of dexmedetomidine promotes non-rapid eye movement sleep stages N2 and N3 sleep. This trial hypothesises dexmedetomidine-induced sleep as pre-emptive therapy for postoperative delirium. Methods and analysis The MINDDS (Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep) trial is a 370-patient block-randomised, placebo-controlled, double-blinded, single-site, parallel-arm superiority trial. Patients over 60 years old, undergoing cardiac surgery with planned cardiopulmonary bypass, will be randomised to receive a sleep-inducing dose of dexmedetomidine or placebo. The primary outcome is the incidence of delirium on postoperative day 1, assessed with the Confusion Assessment Method by staff blinded to the treatment assignment. To ensure that the study is appropriately powered for the primary outcome measure, patients will be recruited and randomised into the study until 370 patients receive the study intervention on postoperative day 0. Secondary outcomes will be evaluated by in-person assessments and medical record review for in-hospital end points, and by telephone interview for 30-day, 90-day and 180-day end points. All trial outcomes will be evaluated using an intention-to-treat analysis plan. Hypothesis testing will be performed using a two-sided significance level (type I error) of α=0.05. Sensitivity analyses using the actual treatment received will be performed and compared with the intention-to-treat analysis results. Additional sensitivity analyses will assess the potential impact of missing data due to loss of follow-up. Ethics and dissemination The Partners Human Research Committee approved the MINDDS trial. Recruitment began in March 2017. Dissemination plans include presentations at scientific conferences, scientific publications and popular media. Trial registration number NCT02856594.
2022-12-27T16:47:20.618Z
72,192,496
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1177/1084822307308954", "MAG": "2016059173", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Foreign service health practitioners (FSHPs) support the realization of the goals and objectives of U.S. embassies and ensure the health unit's operational capacity, from the treatment of minor emergencies to evacuating a patient for advanced emergency care. Effective planning for emergencies as a result of a terrorist attack, natural disaster, or highly communicable disease is contingent on the level of emergency preparedness. A FSHP is uniquely positioned to focus on critical issues involving the assessment of local health care resources and preparing for medical emergencies. This is especially true for assessing the availability and functionality of local medical resources in a developing country such as Sierra Leone, West Africa. The serious deficiencies in Sierra Leone's health system and its lack of ability to respond to medical emergencies demand the FSHP to integrate special knowledge, skills, and abilities that are essential for managing the overall health care services provided at the embassy's health unit.
2022-02-11T10:09:58.648Z
67,913,721
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.2298/VSP0303291C", "MAG": "37057219", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Background. Establishing the value of neurological examination, and additional diagnostic methods (ultrasonography and magnetic resonance imaging of the brain) in the diagnosis and prognosis of hypoxic-ischemic encephalopathy and its treatment, tracking the clinical course, and making the prognosis of neurological development in newborn infants with hypoxic-ischemic encefalopathy. Methods. The group of 40 term newborn infants with suspected intrauterine asphyxia was examined. All the infants were prospectivelly followed untill the 3rd year of age at the Clinic for Neurology and Psychiatry for Children and Youth in order to estimate their neurological development and to diagnose the occurence of persistent neurological disorders. All the infants were analyzed by their gestational age and Apgar score in the 1st and the 5th minute of life. They were all examined neurologically and by ultrasonography in the first week of life and, repeatedly, at the age of 1, 3, 6, 9, 12, 18, as well as in the 24th month of life. They were treated by the standard methods for this disease. Finally, all the infants were examined neurologically and by magnetic resonance imaging of the brain in their 3rd year of age. On the basis of neurological finding infants were devided into 3 groups: infants with normal neurological finding, infants with mild neurological symptomatology, and infants with severe neurological disorders. Results. It was shown that neurological finding, ultrasonography and magnetic resonance imaging of the brain positively correlated with the later neurological development of the infants with hypoxic-ischemic encephalopathy. Conclusion. Only the combined use of these techniques had full diagnostic and prognostic significance emphasizing that the integrative approach was very important in the diagnosis of brain lesions in infants.
2022-02-11T12:34:37.912Z
145,698,966
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/1467-9345.00169", "MAG": "2089093366", "PubMedCentral": null }, "license": null, "status": null, "url": null }
In this article I attempt to clarify an essential difference between the ways in which pictures and words convey meaning. Despite the fact that the distinction between showing and telling is widely understood and clearly marked in ordinary language, it is often ignored when writers and researchers provide accounts of how children’s picturebooks work. As a result, such accounts are often unrealistic, providing distorted images of picturebook text. I briefly examine one such attempt to differentiate and characterise various types of picturebook and then conclude by showing how Anthony Browne exploits the distinction between showing and telling to create the atmosphere of uncertainty and mystery in his classic book Gorilla.
2022-07-09T04:04:02.560Z
151,623,340
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5301/jsrd.5000227", "MAG": "2570731278", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "http://escholarship.mcgill.ca/downloads/hh63t177j" }
Purpose The functional assessment of chronic illness therapy-fatigue (FACIT-F) is commonly used to assess fatigue across diseases. The degree to which the FACIT-F demonstrates measurement equivalence across disease groups, however, is not known. The purpose of this study was to assess differential item functioning (DIF) of FACIT-F items between patients with cancer and systemic sclerosis (SSc or scleroderma). Methods Secondary analysis of FACIT-F data from cancer and SSc patients. Confirmatory factor analysis was used to assess the factor structure of the FACIT-F in cancer and SSc patients. The multiple-indicator, multiple-cause model was utilized to assess DIF, comparing responses from cancer and SSc patients. Results A unidimensional factor structure for the FACIT-F was demonstrated with the cancer (n = 1141), SSc (n = 1186), and combined samples. Statistically significant, but small-magnitude, DIF was found for four items. Compared to cancer patients with the same level of fatigue, SSc patients had lower scores (more fatigue) for item 2 (bodily weakness), 7 (energy), and 8 (ability to perform daily activities); and higher scores (less fatigue) for item 9 (need to sleep throughout the day). For the entire scale, SSc patients had 0.47 SD lower FACIT-F latent factor scores (more fatigue) than cancer patients. After correcting for DIF, there was a change of only 0.03 SD in this difference (0.44 SD lower). Conclusions Although statistically significant DIF was detected for four FACIT-F items, the magnitude was small and the effect on fatigue latent scores was minimal. Thus, FACIT-F scores can be used equivalently in cancer and SSc.
2022-07-08T06:54:52.965Z
96,731,805
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1021/JP101756D", "MAG": "2075210528", "PubMedCentral": null }, "license": null, "status": null, "url": null }
A pure diastereoisomer of a new chiral organic molecule with two asymmetric atoms, (1S, 2S)-2-hydroxymethyl-1-benzyl-1-methylpyrrolidinium, has been prepared and used as structure directing agent (SDA) for the crystallization of the one-dimensional AlPO-5 microporous aluminophosphate. Our main objective is to induce chiral supramolecular arrangements of the SDA molecules within the microporous structure. The SDA molecules can be arranged as monomers or dimers within the nanochannels of AlPO-5, the aggregation being driven by π−π type interactions between the aromatic rings. It has been found that increasing the crystallization time leads to a higher organic content (and lower water incorporation) together with a higher formation of dimers, which indicates that the incorporation of the organic molecules as dimers is thermodynamically favored. We also observe a partially reversible photoinduced rearrangement of the SDAs; the aggregation is enhanced by exciting the occluded monomers with the appropriate wave...
2022-09-12T21:02:14.269Z
231,743,752
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.4103/2212-5531.307101", "MAG": null, "PubMedCentral": null }, "license": null, "status": "CLOSED", "url": null }
Aims and objectives: Mycobacterium tuberculosis (M. tuberculosis) is one of the major threatening infectious diseases and public health in the world. Spoligotyping is a method for r genotyping assay and molecular epidemiology of M. tuberculosis strains. The aim of this study was to determine the molecular epidemiology of M. tuberculosis by spoligotype isolated from patients with tuberculosis at Kurdistan province, Iran. Methods: a total of 47 M. tuberculosis isolates were collected from TB patient at Kurdistan province, Iran. All sample cultures on Lowenstein-Jensen medium and were incubated at 37 °C and were kept for 8 weeks. Bacterial isolates were identified as M. tuberculosis using standard biochemical tests. Multi-drug resistance (MDR) were determined by using proportional method. Spoligotyping was performed. Results: Spoligotyping of 47 strains created 8 patterns. Out of 47 samples, 23 (48.94%) were new Spoligotype International Type (SIT). In preexisting shared pattern STI 2669 were highest degree 23.40% that belong to Ural family of M. tuberculosis spoligotypes. Frequency of MDR were 6.38%. Resistance to Isoniazid and Rifampin were 14.89% and 10.64%, respectively. Conclusion: In overall, half of isolated strains from patients showed new patterns that, indicated the dynamic transmission of tuberculosis. Therefore, highlights dominance of differ pattern of tuberculosis distribution in west Iran. The low frequency of resistance is very interested.
2022-12-02T20:27:05.754Z
253,188,832
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1063/5.0117302", "MAG": null, "PubMedCentral": null }, "license": null, "status": "CLOSED", "url": null }
Artificial superlattice thin films with alternative Pb0.9Sr0.1TiO3 (PST) and SrTiO3 layers were fabricated via pulsed laser deposition. The vortex domains were formed by adjusting the unit cell number of the PST layer to be 20. The electrical response measured by time-resolved synchrotron x-ray diffraction with the repeated pulse voltages of a time interval of 1000 μs indicates that the reorientation of dipole moments in the vortex domains is susceptible to the applied electric field and is a reversible process. Although the centrosymmetric vortex domain structure is not considered to exhibit piezoelectricity, an evident change in the out-of-plane lattice constant with the applied electric field was confirmed. The magnitude of the electromechanical response at 600 kV/cm was estimated to be 19 pm/V, which is nearly comparable to the piezoelectric constant d33 of bulk PbTiO3.
2022-12-02T12:01:38.763Z
52,914,823
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1021/acschemneuro.8b00495", "MAG": "2895138718", "PubMedCentral": null }, "license": null, "status": "BRONZE", "url": "https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.8b00495" }
Quantum dots are nanometer-sized semiconductors that have size-tunable, narrow emission bands, high quantum yields, and are resistant to photobleaching. Ligand-conjugated quantum dots enable the real time visualization of membrane proteins and have revealed that membrane diffusion dynamics are intrinsic to protein regulation, are susceptible to the level of membrane cholesterol, and are altered in genetic variants linked to disease, suggesting a mise en place approach to neuropsychopharmacology.
2022-11-12T18:18:25.495Z
24,507,268
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/j.1365-2702.2012.04084.x", "MAG": "2126366571", "PubMedCentral": null }, "license": null, "status": null, "url": null }
AIMS AND OBJECTIVES To evaluate the correlation between maternal fatigue and uterine contraction pattern at the beginning of the active phase of labour. BACKGROUND Fatigue is one of the most common complaints in pregnant women that often continues until delivery. Maternal fatigue prolongs the labour process and increases the rate of cesarian section. Studies on the pattern of uterine contractions have shown that the length of the fall time is longer in prolonged labours than in normal deliveries. DESIGN A cross-sectional study. METHODS This study was conducted on 100 primiparous women who were referred to Ommolbanin Hospital (Mashhad, Iran) in 2011. Maternal fatigue was assessed at the beginning of the active phase of labour. Then, the pattern of uterine contractions was monitored for 30 minutes by an external tocodynamometer. The F/R ratio was determined by measuring the time for a contraction to return to its baseline from its peak and the time for a contraction to rise to its peak. The data were analysed by chi-square and anova tests. RESULTS The results showed that there was a significant relationship between maternal fatigue and uterine contraction pattern. The F/R ratio was increased with increase in fatigue severity. CONCLUSIONS Fatigue causes changes in the pattern of uterine contractions. The return time of a contraction from its peak to its baseline (fall) is increased with increase in fatigue severity. RELEVANCE TO CLINICAL PRACTICE Offering strategies to prevent tiredness and reduce the related fatigue complications.
2022-11-26T17:04:47.685Z
1,528,625
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/ISCAS.2016.7527499", "MAG": "2518248025", "PubMedCentral": null }, "license": null, "status": null, "url": null }
A Self-rePAiring spiking Neural NEtwoRk (SPANNER) hardware architecture is presented in this paper. It is based on a software model of an astrocyte-neuron network which previously demonstrated the ability to self-detect faults and self-repair autonomously. Experimental results in this paper show that when faults occur at the synapse, remaining healthy synapses of the same neuron are enhanced by the feedback from the astrocyte, which enables system functionality to be maintained. This is the first time that astrocyte cells merged within spiking neurons demonstrate a self-repairing capability in hardware. This repair capability achieves a much more finegrained repair capability in hardware compared to the conventional fault tolerance techniques.
2022-12-14T14:38:34.765Z
87,493,174
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1080/13887890.2015.1086441", "MAG": "2269778126", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The determination of seasonal regulation is important to understand how species have adapted to their local environmental conditions. In this study, we investigate the life history of a North African endemic damselfly, Platycnemis subdilatata, in a northeast Algerian population. We combined field and laboratory investigations to assess the embryonic development, larval growth, emergence pattern and adult flight season. The embryonic development was direct and asynchronous, with 50% of all eggs hatching after three weeks of egg laying and a hatching period ranging from 13 to 51 days. Hatching success was 48.8%, and the causes of hatching failure were infertility and unhatchability. Larval population structure was quite asynchronous during the winter and less so before emergence. The occurrence of larval diapause is improbable due to the increase of the proportion of the last larval stadium in late winter. Emergence was asynchronous with half of the larval population (EM50) emerging after 44 days within an emergence season of 122 days. Sex ratio at emergence was slightly female biased (50.6%). The flight season lasted 133 days starting from early May. The species reached its sexual maturity after six and seven days of emergence in male and female, respectively. Lifespan was not significantly different between sexes with a mean of 7.75 ± 6.45 days (± SD). Our results suggest that the species is univoltine with a typical summer species life history.
2022-12-14T15:59:51.449Z
71,435,501
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1097/00006199-196413040-00041", "MAG": "1984398093", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Hemolytic uremic syndrome is a form of thrombotic microangiopathy which takes its clinical course by a triad of symptoms: microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. We review a considerable amount of literature about the mentioned problem. Two kinds of hemolytic uremic syndrome are known today: the first one is associated with a preceding diarrheal episode, most commonly caused by Escherichia coli, while the second one is not associated with diarrhea, but with different streptococcal infections or genetic mutations. Because antibiotics and anti-diarrheal drugs play a role as a trigger factor for the disease, supportive care is the essential treatment of patients with diarrhea-associated variant of the disease and plasma therapy for nondiarrheal hemolytic uremic syndrome. New therapeutic strategies are developed such as SYNSORB for diarrheal hemolytic uremic syndrome and Eculizumab for the non-diarrheal variant. The prognosis of the disease is auspicious, but what about non-diarrheal forms, up to 25% of patients die in the acute phase and 50% progress to end stage renal disease /ESRD/. For these reasons the characteristics of hemolytic uremic syndrome have to be known in details and physicians have to focus on early diagnosis and treatment of the disease when its prognosis stays auspicious.
2022-12-15T16:24:45.292Z
247,010,691
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1242/jcs.259666", "MAG": null, "PubMedCentral": null }, "license": "publisher-specific, author manuscript", "status": "HYBRID", "url": "https://doi.org/10.1242/jcs.259666" }
Like many pathogenic viruses, SARS-CoV-2 must overcome interferon (IFN)-mediated host defenses for infection establishment. To achieve this, SARS-CoV-2 deploys overlapping mechanisms to antagonize IFN production and signaling. The strongest IFN antagonist is the accessory protein ORF6, which localizes to multiple membranous compartments, including the nuclear envelope, where it directly binds nuclear pore components Nup98-Rae1 to inhibit nuclear translocation of activated STAT1/IRF3 transcription factors. However, this direct cause-and-effect relationship between ORF6 localization and IFN antagonism has yet to be explored experimentally. Here, we use extensive mutagenesis studies to define the structural determinants required for steady-state localization and demonstrate that mis-localized ORF6 variants still potently inhibit nuclear trafficking and IFN signaling. Additionally, expression of a peptide that mimics the ORF6/Nup98 interaction domain robustly blocked nuclear trafficking. Furthermore, pharmacologic and mutational approaches combined to suggest that ORF6 is likely a peripheral-membrane protein, opposed to being a transmembrane protein as previously speculated. Thus, ORF6 localization and IFN antagonism are independent activities, which raises the possibility that ORF6 may have additional functions within membrane networks to enhance virus replication.
2022-12-15T15:27:27.620Z
108,294,484
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1590/1983-1447.2019.20180266", "MAG": null, "PubMedCentral": null }, "license": "CCBYNC", "status": "GOLD", "url": "http://www.scielo.br/pdf/rgenf/v40nspe/en_1983-1447-rgenf-40-spe-e20180266.pdf" }
OBJECTIVE To assess the risk of falls in hospitalized elderly people. METHOD Cross-sectional study with a quantitative approach, carried out at University Hospital of the State of Paraíba. The sample consisted of 284 elderly subjects interviewed from April to October 2016. The Morse Fall Scale was used to evaluate the risk of falls. RESULTS Elderly males (52.5%) aged between 60 and 69 years old (58.1%) and who were not literate (38.7%), prevailed. It was verified that 45% of the sample presented a high risk of falls. The secondary diagnosis and the use of intravenous therapy were the criteria that obtained a higher percentage of elderly at risk. Diuretics (p≤0.032), urinary incontinence (p≤0.001), visual deficit (p≤0.001) and heart failure (p≤0.001) were significantly associated with the high risk of falls. CONCLUSION The use of specific tools in the prevention of falls allows the improvement in the quality of assistance based on scientific evidence, allowing effective intervention and potentiating patient safety.
2022-12-16T23:06:28.992Z
201,869,828
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1074/mcp.RA119.001426", "MAG": "2972211546", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Protein lysine succinylation were investigated together with acetylation, malonylation, crotonylation, and 2-hydroxisobutyrylation in developing rice seeds. The results showed that the modification sites had sequence preferences and the proteins were selected. Some lysine residues of selected proteins were modified by all the five tested modifications in the cell. Given that these moieties are intermediate products of different cellular metabolic pathways, these modifications may mediate the cross-talking among different metabolic pathways via modifying these lysine residues by feedback control. Graphical Abstract Highlights Nonenzymatically Ksu proteins shown different pattern from native cell Ksu proteins. Motif preference of Ksu proteins was associated with different biological processes. Up to 67 developing rice seeds proteins contain PTMs of Kac, Ksu, Kcr, Kmal, and Khib. Some lysine residues of the key pathway enzymes are modified by succinylation. Lysine succinylation has been recognized as a post-translational modification (PTM) in recent years. It is plausible that succinylation may have a vaster functional impact than acetylation because of bulkier structural changes and more significant charge differences on the modified lysine residue. Currently, however, the quantity and identity of succinylated proteins and their corresponding functions in cereal plants remain largely unknown. In this study, we estimated the native succinylation occupancy on lysine was between 2% to 10% in developing rice seeds. Eight hundred fifty-four lysine succinylation sites on 347 proteins have been identified by a thorough investigation in developing rice seeds. Six motifs were revealed as preferred amino acid sequence arrangements for succinylation sites, and a noteworthy motif preference was identified in proteins associated with different biological processes, molecular functions, pathways, and domains. Remarkably, heavy succinylation was detected on major seed storage proteins, in conjunction with critical enzymes involved in central carbon metabolism and starch biosynthetic pathways for rice seed development. Meanwhile, our results showed that the modification pattern of in vitro nonenzymatically succinylated proteins was different from those of the proteins isolated from cells in Western blots, suggesting that succinylation is not generated via nonenzymatic reaction in the cells, at least not completely. Using the acylation data obtained from the same rice tissue, we mapped many sites harboring lysine succinylation, acetylation, malonylation, crotonylation, and 2-hydroxisobutyrylation in rice seed proteins. A striking number of proteins with multiple modifications were shown to be involved in critical metabolic events. Given that these modification moieties are intermediate products of multiple cellular metabolic pathways, these targeted lysine residues may mediate the crosstalk between different metabolic pathways via modifications by different moieties. Our study exhibits a platform for extensive investigation of molecular networks administrating cereal seed development and metabolism via PTMs.
2022-12-18T20:28:42.157Z
3,168,406
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/TR.2011.2134371", "MAG": "2113255471", "PubMedCentral": null }, "license": null, "status": null, "url": null }
In this paper, we discuss linear inference for the lifetime distribution of components based on a Type-II censored lifetime data of reliability systems with known signatures. We derive the best linear unbiased estimators (BLUE) for the parameter(s) in general scale and location-scale parameter families. The exact computational formulas of the BLUE and their variances and covariance are provided. Selected tables of the coefficients of BLUE are presented for the exponential and extreme value distributions. Using these, best linear unbiased predictors of future system failure times are discussed. Finally, two examples are provided to illustrate all the methods of inference developed here.
2022-12-19T06:46:58.632Z
3,090,742
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/ICPR.2016.7899611", "MAG": "2608008283", "PubMedCentral": null }, "license": null, "status": null, "url": null }
As different staining patterns of HEp-2 cells indicate different diseases, the classification of Indirect Immune Fluorescence (IIF) images on Human Epithelial-2 (HEp-2) cell is important for clinical applications. Different from traditional pattern recognition techniques, we use CNN to extract more high-level features for cell images classification. Compared to the existing CNN based HEp-2 classification methods, we proposed a network with deeper architecture. A class-balanced approach is also proposed to augment the HEp-2 cell dataset for network training. The proposed framework achieves an average class accuracy of 79.29% on ICPR 2012 HEp-2 dataset and a mean class accuracy of 98.26% on ICPR 2016 HEp-2 training set.
2023-01-01T18:49:12.254Z
237,546,601
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1177/1358863X211034919", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
Among patients with unprovoked venous thromboembolism (VTE), the benefit of advanced cancer screening with abdomino-pelvic computed tomography (AP-CT) scan1 or 18-fluorodeoxyglucose positron emission tomography (18FDG PET) scan2 was low. Thus, guidelines do not support the use of CT or PET in routine cancer screening.3 However, the issue of cancer screening according to the clinical presentation of VTE is still debated, especially for bilateral deep vein thrombosis (DVT). This subgroup was outside the scope of the main studies that support current recommendations and previous reports have suggested that bilateral DVT was significantly associated with cancer.4 In this study, we aimed to report the prevalence of occult cancer diagnosed with systematic CT scan in patients admitted for unprovoked VTE according to the presence of bilateral DVT. We retrospectively reviewed the records of patients admitted to Rouen University Hospital, France, between 2007 and 2016, with a new diagnosis of symptomatic VTE (lower limb DVT, pulmonary embolism [PE], or both). Patients who underwent AP-CT (with thorax if CT pulmonary angiography [CTPA] was not initially performed) for cancer screening were included in the analysis. All patients admitted for PE and/or DVT were routinely investigated with bilateral whole leg colour-Doppler ultrasound (CDUS). A cancer was retrospectively adjudicated as occult if the patient with newly diagnosed cancer within 1 year after the thrombotic event was asymptomatic with normal physical examination and normal first-line test results (blood test, mammography, prostate-specific antigen [PSA]) at the time of VTE. A total of 891 patients were identified with lower limb DVT or PE. Of these, 435 (48.8%) events were provoked by transient, persistent risk factors or did not have AP-CT. Of the remaining 456 patients, mean age was 67.7 ± 16.3 years and 216 (47.3%) were male. PE was identified in 315 (69.1%) patients and DVT in 303 (66.44%), including bilateral DVT in 47 (10.3%) cases. A cancer was diagnosed in 83 (18.4%, 95% CI: 15.1–22.2%) patients at the time of the thrombotic event or within the 1-year follow-up. Out of the 83 patients, 31 had a malignancy suspected on the AP-CT scan performed for the diagnosis of PE. Multivariate analysis demonstrated a significant association between malignancy and age over 60 years (odds ratio [OR] = 3.4, 95% CI: 1.5–7.6; p < 0.004), active smoking (OR = 3.0, 95% CI: 1.3–6.8; p = 0.01), and bilateral DVT (OR = 3.3, 95% CI: 1.6–6.5; p < 0.001). Incidence of cancer diagnosis over time was more frequent in patients with bilateral DVT at presentation (hazard rate [HR] = 2.8, 95% CI: 1.64– 4.85; p < 0.001). This association was previously reported in the large MASTER cohort, with a significantly higher incidence of bilateral DVT in patients with cancer than in patients without cancer (8.5% vs 4.6%; p < 0.01).4 Another study reported an association between cancer and bilateral DVT, with an OR = 2.5 (95% CI: 1.3–4.8%).5 In addition, Le Gal et al. evidenced an association between cancer and bilateral DVT even when the contralateral DVT was asymptomatic.6 In our study, among the 83 patients with a diagnosis of cancer, 18 (21.7%, 95% CI: 14.2–31.7%) were considered occult. Out of the 18 cases, CT scan failed to detect an occult cancer in only two patients. Finally, regarding the whole population, the frequency of occult cancer was 3.9%, and despite a high prevalence of cancer in our population, the rate of occult cancer diagnosed on systematic AP-CT scan was only 2.6% (95% CI: 1.5–4.5%) of cases, which is similar to the results reported in the SOME trial.1 However, when we consider patients with bilateral DVT, the rate of occult cancer diagnosed with the CT-based strategy was 12.8% (95% CI: 5.9–24.7%). Bilateral deep vein thrombosis: Time to screen for occult cancer?
2022-02-07T20:47:02.518Z
183,659,048
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1556/ArchErt.135.2010.9", "MAG": "2579508186", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Die romischen Meilensteine, die 1955 gefunden wurden, aber seitdem verloren sind, werden in dieser kleinen Mitteilung aufgrund der Dokumentation von Andras Mocsy veroffentlicht. | 1955 szeptembereben tobb merfoldkőtoredek es ket felirat kerult elő Nyergesujfalu keleti hataraban, amelyek eddig rovid emliteseken kivul nem kerultek reszletes kozlesre. Mocsy Andras Magyar Nemzeti Muzeumban őrzott adattari jelentese, amelyet itt teljes szovegevel kozlunk, valamint a helyszinen keszitett fotoi alapjan harom merfoldkő olvasatat es reszleges kiegesziteset adjuk, amelyek kozul az első Septimius Severus korara (8. kep), a masik kettő pedig Claudius Gothicus korara keltezhető (3. es 5., ill. 4. kep). Mivel az 1955-ben talalt feliratok mar az 1970-es evek elejere elvesztek, jelen kozlemeny celja, hogy a kutatas szamara hozzaferhetőve tegye a rendelkezesre allo adatokat.
2022-02-08T12:17:50.434Z
102,604,859
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.31293/AF.V17I1.3353", "MAG": "2792275500", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The research objective were to study the effect of compost fertilizer and Nasa liquid organic fertilizer (POC Nasa) and its interaction on the growth and yield of cucumber and also to find the proper dosage of compost fertilizer and POC Nasa concentration for obtaining the best growth and yield of cucumber. The research used Completely Randomized Design (CRD) in 4 x 4 Factorial Experiment and three replications.  The factor was the dosage of compost fertilizer (K) consisting of 4 levels : no compost fertilizer application (k0), 48 g polybag -1 (k1), 64 g polybag -1 (k2); and 80g polybag -1 (k3).   The second factor was the concentration of POC Nasa (D) consisting 4 levels : no POC Nasa application (d0), 1 ml l -1 water (d1),  2 ml l -1 water (d2), and 3 ml l -1 water (d3). The results showed that: (1) the compost fertilizer treatment affected significantly on the weight of one fruit and the weight of fruit per plant, it affected very significantly on the plant lenght at age 15 and 30 days after planting, and fruit diameter, but it did not affect significantly on the number of fruit per plant.  The best production was produced at 48 g polybag -1 (k1) treatment of 3,77 kg plant -1 , while the least one was produced at the 80 g polybag -1 (k3) treatment of 3,06 kg plant -1 ; (2)the POC Nasa treatment affected significantly on the weight of one fruit; and it affected very significanly on the plant lenght at age 30 days after planting and fruit diameter, but it did not affect significantly on the plant lenght at age 15 days after planting, number of fruit per plant, and fruit weight per plant;  and (3) the interaction treatment between compost fertilizer and POC Nasa affected significantly on the weight of one fruit and affected very significantly  on the fruit diameter, but did not affect significantly on the plant lenght at age 15 and 30 after planting, the number of fruit and fruit weight per plant.
2022-05-29T19:21:06.716Z
88,614,180
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1128/MICROBE.1.235.1", "MAG": "2401908513", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The genomes of bacteria are dynamic —subject to homologous recombination, gene duplication and loss, and lateral gene transfer (LGT). Given these dynamics, even closely related microorganisms with identical 16S rRNA sequences can prove to be extraordinarily diverse structurally and to contain large numbers of unique or strain-specific genes.
2022-07-31T06:50:45.803Z
111,934,595
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1021/CEN-V087N020.P036", "MAG": "2322792965", "PubMedCentral": null }, "license": null, "status": null, "url": null }
THE PROMISE OF significant new government funding for scientific research and of new leaders for federal science positions in the Obama Administration have produced a general euphoria in the nation’s science policy community. How long that feeling might last depends on how effectively the new Administration can follow through on its promises. Much of the feel-good mood was on display at the recent American Association for the Advancement of Science’s 34th Annual Forum on Science & Technology Policy, held on April 30 and May 1 in Washington, D.C. Just three days earlier, President Barack Obama spoke before the National Academy of Sciences, where he strongly stated his support for science and technology (C&EN, May 4, page 7). His speech provided an optimistic backdrop for this meeting of nearly 600 policymakers from government, universities, industry, and think tanks who were there to learn where science policy is headed during the next year. Two members of the ...
2022-09-09T09:22:35.605Z
23,470,078
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1093/MILMED/158.12.794", "MAG": "69477964", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Tablets containing tetraglycine hydroperiodide are used to purify small quantities of water for drinking. Because short-term administration of stable iodide can alter thyroid function in normal adults, we evaluated the effects of these tablets on thyroid function during a military field training exercise. Fourteen normal volunteers participated in the study. After an adjustment period of 2 weeks to the field environment, half of the subjects received four dissolved water-purification tablets (32 mg free iodine) daily for 7 consecutive days while the other half served as controls. At the end of the study the treatment group showed reductions in the mean serum levels of thyroxine (14%) and total triiodothyronine (15%) and significant increments in basal thyrotropin (TSH) (122%) and the TSH response to thyrotropin-releasing hormone (49%) compared to baseline values. The basal TSH level rose above the normal range in two subjects. No significant changes in any parameter of thyroid function were observed in the control subjects. One week of daily exposure to the iodine load from four tetraglycine hydroperiodide water-purification tablets causes mild impairment of thyroid function in humans.
2022-09-11T13:29:31.760Z
23,605,167
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/MWSYM.2014.6848276", "MAG": "2017326865", "PubMedCentral": null }, "license": null, "status": null, "url": null }
A simple technique for accurate and low-cost modeling of microwave structures is presented. Our approach utilizes response surface approximation at the level of suitably selected response features rather than direct approximation of frequency responses (e.g., S-parameters) of the structure of interest. By exploiting the fact that dependence of the features on designable parameters is much less nonlinear than similar dependence for original responses, accurate quasi-global surrogates can be constructed at a fraction of computational cost necessary by conventional modeling techniques. Numerical verification involving two microstrip filters is provided.
2022-09-10T09:01:53.621Z
250,340,249
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1145/3477495.3531831", "MAG": null, "PubMedCentral": null }, "license": null, "status": "BRONZE", "url": "https://dl.acm.org/doi/pdf/10.1145/3477495.3531831" }
In few-shot relational triple extraction (FS-RTE), one seeks to extract relational triples from plain texts by utilizing only few annotated samples. Recent work first extracts all entities and then classifies their relations. Such an entity-then-relation paradigm ignores the entity discrepancy between relations. To address it, we propose a novel task decomposition strategy, Relation-then-Entity, for FS-RTE. It first detects relations occurred in a sentence and then extracts the corresponding head/tail entities of the detected relations. To instantiate this strategy, we further propose a model, RelATE, which builds a dual-level attention to aggregate relation-relevant information to detect the relation occurrence and utilizes the annotated samples of the detected relations to extract the corresponding head/tail entities. Experimental results show that our model outperforms previous work by an absolute gain (18.98%, 28.85% in F1 in two few-shot settings).
2022-12-10T08:19:12.040Z
41,739,051
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1176/AJP.142.7.811", "MAG": "2409513133", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The authors took multiple serum samples for measurement of melatonin between 4:30 p.m. and 7:30 a.m. in seven male depressed patients with melancholia and five healthy male control subjects and found that melancholic patients had a significantly lower rise of melatonin. They also compared a second, separate group of 14 women and five men suffering from melancholic depression with seven healthy male control subjects and nine depressed women without melancholia. The melancholic patients had a significantly lower concentration of serum melatonin at 11:00 p.m. than either the control subjects or the nonmelancholic depressed patients. These findings support the possibility that the functioning of the pineal gland is altered in these patients.
2022-12-16T03:56:42.615Z
76,373,576
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.4009/JSDT1985.23.1021", "MAG": "2315711832", "PubMedCentral": null }, "license": null, "status": null, "url": null }
key words: chronic renal failure, gastric mucosal lesions, gastric mucosal HCO3secretion, gastric mucosal blood flow, Campylobacter pylori <要旨> 慢性腎不全患者の胃粘膜病変の原因解明のため血液透析患者 (137名) に内視鏡検査を行い胃粘膜病変の頻度および 発生部位について検討 し, さらに胃粘膜防御機構に関して血中HCO3-濃 度測定 (66名), レーザー ドップラー法によ る胃粘膜血流量の測定 (46名) を行った. また胃疾患との関連性が指摘 されているCampylobacter pyloriを胃粘膜 より培養法にて検出 (23名) した. 血液透析患者の胃粘膜病変には, びらん性胃炎, 胃潰瘍, 急性胃炎などが多くみ られ, その発生部位は胃前庭部に多かったが急性胃炎については胃体部にも66.7%に 病変が認められた. 血液透析患 者の血中HCO3-濃 度は19.5±2.6mEq/lと コントロール群に比較して低値を示した. 血液透析患者ではコントロー ル群との比較で胃体上部大彎にて胃粘膜血流量の低下がみられた. Campylabacter pyloriの検出率は43.5%で コン ト ロール群と有意差は認めなかった. 以上より慢性腎不全患者における胃粘膜病変の原因として血中HCO3-濃 度低下に よる胃粘膜HCO3-分 泌の低下, 胃体部の胃粘膜血流量の低下などの胃粘膜防御機構の障害が関与していると考えられ た.
2022-05-31T04:24:04.563Z
121,046,945
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1143/JPSJ.20.1212", "MAG": "2016966233", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Proton chemical shifts in nuclear magnetic resonance spectra of styrene were semi-empirically evaluated by considering the following effects: (i) The π-ring current effect, (ii) the magnetic anisotropy effect of neighboring carbon atoms, (iii) the local diamagnetic shielding of the hydrogen atom, and (iv) the partial ring current effect. Calculated values are -0.40 ppm and -0.82 ppm for β- and α-protons, respectively, referred to the proton trans to the phenyl group and the observed values are -0.50 ppm and -1.50 ppm, respectively.
2022-09-04T18:44:07.556Z
26,378,666
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1107/S1600536810029235", "MAG": "2402306588", "PubMedCentral": "2983176" }, "license": null, "status": null, "url": null }
Hexamethylphosphoramide (hmp), tetrathiotungstate, silver sulfide and dysprosium nitrate were self-assembled, forming an anionic [AgWS4]nn − chain in the title compound, {[Dy(NO3)2(C6H18N3OP)4][AgWS4]}n. The central Dy atom in the cation is coordinated by eight O atoms from two didentate nitrate and four hmp ligands, giving rise to a distorted square antiprismatic structure. Together with the two nitrate ligands, the cation is univalent, which leads to the anionic chain having a [WS4Ag] repeat unit. The polymeric anionic chain, with W—Ag—W and Ag—W—Ag angles 161.16 (2) and 153.606 (11)°, respectively, presents a distorted linear configuration. The title compound is isotypic with other rare earth complexes.
2022-11-11T08:22:46.223Z
129,847,555
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.2113/174.2.125", "MAG": "2013766868", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The Saint-Gilles breccias, on the western flank of Piton des Neiges volcano, are clearly identified as debris avalanche deposits. A petrographic, textural and structural analysis of the breccias and inter-bedded autochthonous lava flows enables us to distinguish at least four successive flank slides. The oldest deposit sampled the hydrothermally-altered inner parts of the volcano, and has a large volume. Failure was favored by the presence of a deep intensely-weathered layer. The younger deposits are from superficial sources, as their products are rarely hydrothermalized and are more vesicular. The breccia formation, and especially the progressive breaking up occurring during the debris avalanche displacement, indicates the existence of high speed transport. In the Cap La Houssaye coastal area, abrasion and striation of the underlying lava formation, as well as the packing features observed in the breccia, are considered to be deceleration structures.
2022-11-27T23:39:03.003Z
10,401,335
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1074/mcp.M300005-MCP200", "MAG": "2135533040", "PubMedCentral": null }, "license": null, "status": null, "url": null }
While protein-protein interactions have been studied largely as a network graph without physicality, here we analyze two protein complex data sets of Saccharomyces cerevisiae to relate physical and functional modularity to the network topology. We study for the first time the number of different protein complexes as a function of the protein complex size and find that it follows an exponential decay with a characteristic number of about 7. This reflects the dynamics of complex formation and dissociation in the cell. The analysis of the protein usage by complexes shows an extensive sharing of subunits that is due to the particular organization of the proteome into physical complexes and functional modules. This promiscuity accounts for the high clustering in the protein network graph. Our results underscore the need to include the information contained in observed protein complexes into protein network analyses.
2022-12-19T14:18:14.453Z
128,427,199
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1029/TR022i002p00336", "MAG": "2089740414", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The first leveling of first-order accuracy in the Alluvial Valley of the Mississippi was run in 1876 and 1877 when the Corps of Engineers leveled from Cairo, Illinois, to Columbus, Kentucky, and from Memphis, Tennessee, to Friar Point, Mississippi. Between 1879 and 1881 the United States Coast and Geodetic Survey ran a line from New Orleans, Louisiana, to Greenville, Mississippi, where the work was taken up by the Corps of Engineers and continued to Arkansas City, Arkansas. Leveling proceeded at a steady rate, until by 1906 the Alluvial Valley was covered by a network of lines, and the original lines along the river had been rerun.
2022-02-09T15:40:11.885Z
107,715,816
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/j.1551-8833.1924.tb14235.x", "MAG": "300344396", "PubMedCentral": null }, "license": null, "status": null, "url": null }
No member present had had any experience with any solution for cleaning service pipes. Mr. Dow R. Gwinn stated that he used a stiff wire to loosen deposits. Mr. Charles B. Yobst used a force pump and got good results, he did not dig up at the main, but pumped from the meter connection. Asked if the force pump would clear lime deposits, Mr. Yobst stated that the water he was supplying was soft and the deposits largely vegetable. He also said that in lead pipe the lime deposits were not hard and were easily forced back into the mains.
2022-02-10T07:36:32.672Z
3,605,741
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/jmwh.12636", "MAG": "2704566030", "PubMedCentral": null }, "license": null, "status": null, "url": null }
&NA; This article provides information on recent changes in the US Food and Drug Administration (FDA) labeling and safety regulations for mifepristone (Mifeprex). The revised label now permits midwives, advanced practice nurses, and physician assistants to order and prescribe mifepristone, eliminating the requirement for physician supervision. The updated label also extends eligibility for use from 49 to 70 days' gestation and decreases the number of required visits from 3 to 2. The recommended dose of mifepristone has been reduced, and the dosage, timing, and route of administration for misoprostol have also been changed to reflect current research. These changes have implications for clinical practice and may lead to expanded access for women in the United States.
2022-03-10T13:04:09.328Z
11,878,667
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1201/9780203489550.ch33", "MAG": "2501706387", "PubMedCentral": null }, "license": null, "status": "CLOSED", "url": null }
CONTENTS 33.
2022-09-11T12:25:40.917Z
111,186,644
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/PICA.1995.515277", "MAG": "2531679009", "PubMedCentral": null }, "license": null, "status": null, "url": null }
After a three-year research and development project that included a collaborative effort by EPRI and 20 electric utilities and vendors in the USA, two electric utilities conducted full-scale demonstrations of a proposed international standard, UCA compliant protocol for communicating between power system control centers. The recently developed Intercontrol Center Communications Protocol (ICCP) was implemented and tested at Western Area Power Administration's (WAPA) Loveland area office and at Ohio Edison (OE) company. A third node at the vendor, Harris Controls, allowed demonstration of routing and networking capabilities.
2022-09-13T05:58:16.368Z
198,086,064
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.15673/RET.V55I2.1360", "MAG": "2950246801", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Різні споживачі (металургія, великотоннажна хімія, енергетика, медицина і т.п.) потребують газоподібний кисень, стиснений до тисків 0,6...16 МПа. У першій половині 20-го століття створювали кріогенні повітророзподільні установки (ПРУ), в яких вироблений газоподібний кисень на виході з блоку розділення стискувався в кисневому компресорі (поршневому або відцентровому) до необхідного тиску. Після появи кріогенних насосів кисень стали стискати в них, а потім газифікувати з використанням теплоти потоку переробляємого повітря. На перший погляд ця схема здавалася досить ефективною, хоча і не позбавленою деяких недоліків. Проведено термодинамічний аналіз повітророзподільних установок для отримання газоподібного кисню під тиском. Виконано порівняння показників ПРУ, які працюють за схемою із стисненням продукційного кисню в компресорі і зі стисненням в насосі рідкого кисню з наступним нагріванням до температури навколишнього середовища в основному теплообміннику. В результаті проведеного аналізу виведено безрозмірний критерій, фізичний зміст якого полягає в тому, що він показує відношення роботи, що витрачається в кисневому компресорі до додаткової роботи, яку необхідно затратити для компенсації термодинамічних втрат, пов'язаних з роботою насоса рідкого кисню. Розглянуто приклад використання отриманих співвідношень для аналізу ПРУ, що працює по циклу середнього тиску і призначеної для отримання газоподібного кисню під тиском 16 МПа. Термодинамічний аналіз такої установки показує, що витрата енергії на стиснення кисню в схемі з насосом може бути в 1,5 рази менше витрати енергії при використанні кисневого компресора. Аналіз ПРУ низького тиску показав, що при тиску продукційного кисню нижче 7-8 МПа схеми з насосом рідкого кисню більш ефективні, ніж традиційні схеми із стисненням продукційного кисню в компресорі. При тиску продукційного кисню вище 7-8 МПа енергетично вигідніше стає схема з кисневим компресором.
2022-11-11T07:50:20.371Z
7,292,483
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/J.1440-1673.1995.TB00318.X", "MAG": "2027920800", "PubMedCentral": null }, "license": null, "status": null, "url": null }
A summary of a conference reviewing recent developments and changes in the use of radiation therapy in paediatric oncology is reported. Although the use of radiation therapy has resulted in improved cure rates, the long-term complications of radiation in a paediatric population are recognised. More intensive systemic therapy and the increasing availability of prognostic data, including biological markers to tailor therapy to the individual patient, has resulted in a more selective use of radiation therapy. Changes in the management of specific tumour types are discussed.
2022-12-20T14:53:17.293Z
141,216,600
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.4324/9780429046247-2", "MAG": "2952807788", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Much of the concern with juvenile delinquency has been based on the premise that delinquent behavior leads to adult crime. Police and court records of three cohorts comprised of 6,127 persons were analyzed. The most prevalent pattern of delinquent behavior was one of declining seriousness and discontinuation after the teenage period. With few exceptions, intervention by the agencies of social control did not play even a moderate role in decreasing the seriousness of adult controls. It was apparent that police contacts and more serious contacts had their highest incidence in the inner city. While removal from the community may appear to be a solution, the records show that most juveniles and adults will return and must be integrated into the community. (JAC) *********************************************************************** * Reproductions supplied by EDRS are the best that can be made * * from the original document. * ***********************************************************************
2022-12-20T21:11:34.050Z
4,476,715
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5334/ijic.3046", "MAG": "2783584488", "PubMedCentral": "5854087" }, "license": "CCBY", "status": "GOLD", "url": "http://www.ijic.org/articles/10.5334/ijic.3046/galley/4714/download/" }
Survivors of childhood and adult-onset cancer are at lifelong risk for the development of late effects of treatment that can lead to serious morbidity and premature mortality. Regular long-term follow-up aiming for prevention, early detection and intervention of late effects can preserve or improve health. The heterogeneous and often serious character of late effects emphasizes the need for specialized cancer survivorship care clinics. Multidisciplinary cancer survivorship care requires a coordinated and well integrated health care environment for risk based screening and intervention. In addition survivors engagement and adherence to the recommendations are also important elements. We developed an innovative model for integrated care for cancer survivors, the “Personalized Cancer Survivorship Care Model”, that is being used in our clinic. This model comprises 1. Personalized follow-up care according to the principles of Person Centered Care, aiming to empower survivors and to support self management, and 2. Organization according to a multidisciplinary and risk based approach. The concept of person centered care is based on three components: initiating, integrating and safeguarding the partnership with the patient. This model has been developed as a universal model of care that will work for all cancer survivors in different health care systems. It could be used for studies to improve self efficacy and the cost-effectiveness of cancer survivorship care.
2022-12-31T18:04:49.762Z
234,788,144
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/CICC51472.2021.9431492", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
With the growing demand for on-chip, low-power clock references in emerging sensor and IoT systems with extreme power limitations, performance of these frequency references requires continued improvement in energy efficiency, area, frequency stability, and frequency reconfigurability. RC oscillators using a frequency-locked loop (FLL) [1 – 6] formed by a frequency detector (FD), an error amplifier, and a voltage-controlled-oscillator (VCO) are increasingly used. Compared to a conventional RC relaxation oscillator, the absence of a PVT-sensitive comparator enhances frequency stability. The FD is the dominant FLL block for determining power, noise, and frequency stability performance of the oscillator. In [1], [2], a differential FD provides superior immunity to supply and ground noise, however these topologies lack frequency reconfigurability without changing RREF and CREF. In [3 – 6], the FD is implemented using a switched-capacitor and a voltage reference with resistor, where frequency can be adjusted using the reference voltage. However, voltage-domain adjustment is limited by the DC operating range, and generation of a stable, adjustable on-chip voltage reference is required.
2022-01-27T08:48:18.293Z
98,823,528
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/CBER.19520850215", "MAG": "2092651973", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Die Einwirkung von Ammoniak auf Benzaldehyd-sulfonsaure-(2)-chlorid bei 60° unter Druck fuhrt zu Saccharin-imin.
2022-01-27T13:28:38.393Z
191,473,264
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1179/JBA.1985.138.1.132", "MAG": "2076868619", "PubMedCentral": null }, "license": null, "status": null, "url": null }
AbstractDuring the eighteenth century, and into the nineteenth, brick-tiles (or mathematical tiles) were a fairly frequently used building material in the counties of Kent, Surrey, and Sussex. Away from this area they were used less commonly. Contrary to what used to be thought, it is now known that their use owes nothing to the Brick Tax since they were themselves subject to that tax from its inception. They were especially useful for bringing timber-framed buildings up-to-date, although they were also used de novo on light timber-framed buildings as well as in other contexts. The pressures to bring up-to-date were always strongest in the towns, and brick-tiles are predominantly, though by no means exclusively, an urban phenomenon. Although they could give a convincing appearance of a brick face, nevertheless angles, window and doorway openings, and the heads of buildings presented difficulties. Various means of dealing with such problems were devised.
2022-02-08T09:03:17.716Z
197,862,235
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.17507/TPLS.0907.06", "MAG": "2953805570", "PubMedCentral": null }, "license": null, "status": null, "url": null }
With the development of globalization, cultural exchanges have been widely concerned. And the translation of Chinese literary works has become a trend. Due to the pivotal position of architecture name in literary works, coupled with the rich connotations and communicative function, architectural translation is of great. The building names in the classical novel Hong Lou Meng contained meaningful Chinese cultural connotations,so when translating these names,the literature and culture elements should be taken into consideration. This paper makes a comparative study between Yang Xianyi’s and Hawkes’ translation on the base of language and culture, picking up some typical buildings to do the case study and exploring the charm of Chinese ancient architecture culture. At last, in the hope of giving some reference to the practical translation process, the paper will give some suggestions in some architecture translation.
2022-02-08T06:26:17.711Z
233,764,023
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.2139/ssrn.3665000", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
We develop a new method of assessing conditional conservatism using more detailed data available from the insurance industry. We look at how conditional conservatism affects insolvency risk and the financial strength rating of property-liability (P&amp;L) insurance companies. We also investigate how a change to accounting rules affects conditional conservatism. The P&amp;L insurance industry is a perfect setting for studying accruals because we have specific and detailed firm-year level information about loss accrual development. The data enable us to develop a new method of measuring conditional conservatism, which is based on the concavity of the loss development curve. We study U.S. domiciled P&amp;L insurance companies from 1995 to 2015. We find that the greater the degree of conditional conservatism, the lower is insolvency probability, and the better is the financial strength rating, with other things being constant. The result indicates that regulators and rating agencies reward insurers that voluntarily utilize conditional conservatism accounting strategy. Moreover, we find that the level of conditional conservatism is reduced after the enactment of the Model Audit Rule (MAR). MAR, like the Sarbanes-Oxley Act Section 404, increased board oversight of internal risk management. Our result provides evidence that complying with additional disclosure requirements reduces P&amp;L insurers’ incentives to use conditional conservatism to mitigate regulatory monitoring costs.
2022-07-06T15:44:08.101Z
83,713,906
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1071/AR06097", "MAG": "1984565636", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Delving is a farming practice involving the mixing of a deep clayey subsoil layer with a sandy topsoil. One of the many effects of this practice is to reduce soil albedo and increase water-holding capacity of the topsoil, thus increasing the potential for storage and release of heat and potential attenuation of the effects of radiative frost. At Keith, a frost-prone location of South Australia, we investigated the effect of management practices with putative capacity to reduce frost damage, with emphasis on delving. Three field experiments were established on Brown Sodosols with a water-repellent sand topsoil. In relation to crops in untreated control soil, delving increased wheat yield from 1.9 to 3.1 t/ha in 2003, and from 0.5 to 1.5 t/ha in 2004. This large delving effect contrasted with the minor effects of other treatments including soil rolling, sowing rate, row spacing, and cultivar mixture. Lack of significant interactions between treatments indicated a robust response to delving across a range of management practices. Topsoil and canopy-height minimum temperatures were consistently higher in the delved treatment. The average difference in canopy-height minimum temperature between delved and control treatments was 0.3–0.4°C, with a maximum of 1.6°C in 2003 and 1.2°C in 2004. A single, robust relationship between yield and frost damage fitted the data pooled across treatments and seasons. This, together with the temperature differential between treatments, and significant relationships between minimum canopy-height temperature around flowering and frost damage supported the conclusion that a substantial part of the yield gain attributable to delving was related to reduced frost damage.
2022-09-09T13:11:43.354Z
8,483,563
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/dev.21441", "MAG": "2469440976", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The aim of this study was to establish whether exposure of pregnant rats to uncontrollable (psychological) stressors might change the likelihood of their offspring to exhibit functional and histopathological abnormalities suggestive of asthma in adulthood. Pregnant rats (n = 16) underwent one of three treatments: electric shocks of a maximum duration of 10 s that could be escaped (controllable group; C) those that could not be escaped (uncontrollable group; U) or no shocks (control group; N). The offspring (n = 54) were kept in animal house under standard conditions until 3 months of age, when lung hyperresponsiveness, histopathology, immunohistochemical measurements of the cytokines interleukin (IL) 2, IL-4, IL-5, and IL-13 and actin as well as oxidative stress based on iNOS-positive cell counts and isoprostane PGF2α contents were assessed. The results showed that prenatal exposure to physical stressors (shocks) caused lung hyperresponsiveness and increased cytokine expression; exposure to uncontrollable shock (group U) had a differential effect on the expression of IL-2, IL-5, and IL-13 in inflammatory cells compared to exposure to controllable shock (group C), which characterizes the "psychological" aspect of stress. The results show that not only stress but also its uncontrollability during gestation might increase the likelihood that the offspring will exhibit functional and histopathological abnormalities suggestive of asthma. These findings strengthen the importance of psychological control with regard to environmental stimuli for the occurrence of several illnesses, suggesting the desirability of integration among various fields of science.
2022-09-08T09:32:48.563Z
71,203,545
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.3171/JNS.1972.37.6.0653", "MAG": "2012836451", "PubMedCentral": null }, "license": null, "status": null, "url": null }
✓ Ten patients who had cervical myelopathy due to ossification of the posterior longitudinal ligament of the cervical spine are described. This disease is characterized by an abnormal longitudinal strip of ossified ligamentous tissue along the posterior margin of vertebrae from C-3 to C-6; the primary lesion appears to be a degeneration of the intervertebral disc. This distinct clinical, radiological, and pathological entity should be included in the differential diagnosis of cervical myelopathy. All 10 patients were treated by extensive decompressive laminectomy and multiple bilateral facetectomies, with or without foramen magnum decompression. The results were favorable, and postoperative myelography demonstrated dorsal migration of the entire dural contents.
2022-12-19T07:11:06.489Z
22,506,735
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1177/0886260507313969", "MAG": "2136393182", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "https://europepmc.org/articles/pmc2562919?pdf=render" }
Measurements of intimate partner violence (IPV) based on acts of violence have repeatedly found substantial bilateral violence between intimates. However, the context of this violence is not well defined by acts alone. The objective of this research was to compare differences in women and men within each IPV status category (victim, perpetrator, and both) with respect to levels of battering as defined by their scores on the Women's Experience With Battering Scale (WEB), which asks gender-neutral questions about the abuse of power and control and fear in an intimate relationship. In our study, women disclosed higher levels of battering on the WEB, despite IPV status (victimization or both victimization and perpetration). In addition, female IPV victims were 5 times more likely than their male counterparts to disclose high rates of battering on the WEB. Depressive symptoms, symptoms of posttraumatic stress disorder, African American race, and IPV victimization were independently associated with higher WEB scores.
2022-12-21T01:06:37.215Z
237,846,617
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.13057/BIODIV/D220742", "MAG": "3181496933", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Abstract. Hamaidia K, Soltani N. 2021. Short communication: New report of Aedes albopictus in Souk Ahras, Northeast Algeria. Biodiversitas 22: 2901-2906. The present paper reports the occurrence of Aedes albopictus (Skuse), an aggressive Asian tiger mosquito in the city of Souk-Ahras (Northeast of Algeria). A “26 April” estate’ inhabitants (Souk-Ahras province) have reported unusual daytime bites by a striped mosquito. On early September 2020, an intensive field inspection was carried out for potential mosquito breeding sites in the locations around the city. A total of 105 specimens (8 larvae, 24 pupae and 73 adults) of Ae. albopictus were collected in a pile of old tyres in a residential garden. After previous records of this species in Algeria, this is the first evidence of its presence in Souk-Ahras province, and the findings enhance combined public participation with professional validation in surveillance of vector borne-diseases programs with emphasis on the need for sensitising citizens about controlling this important vector.
2022-08-29T02:34:56.288Z
36,392,252
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1364/OL.37.003048", "MAG": "2094111562", "PubMedCentral": null }, "license": null, "status": null, "url": null }
We developed a structured interference optical coherence tomography (SIOCT) to enhance the lateral resolution beyond the diffraction limit. A sinusoidal pattern is created on the interferometric beam with the reference intensity temporally modulated. In the Fourier domain, the high spatial frequencies are shifted into the detectable range, which enhances the lateral resolution beyond the diffraction limit by a factor of 2. The lateral resolution of SIOCT was characterized in our study as ~5.5 μm, surpassing the diffraction limit ~9.6 μm as in conventional Fourier-domain optical coherence tomography. SIOCT was demonstrated on phantoms and ex vivo adipose tissues.
2022-09-14T10:42:20.557Z
232,326,944
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1145/3453187.3453402", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
The resource scheduling problem in cloud computing is one of the most concerned issues of researchers in related fields in recent years. With the aim of solving defects in particle swarm optimization algorithm (PSO) that it is easy to fall into local optimal solution and "premature", we propose a particle swarm optimization scheduling algorithm based on adaptive weights. By improving the inertia weight factor and using the number of iterations to control the size of the inertia weight, the algorithm convergence speed can be accelerated. Meanwhile, by updating the particle speed to update the weights of the cognitive and social coefficients in the number of iterations, the fitness function of the particles is improved to strengthen the adaptive ability of the particles and made the algorithm more in line with objective laws. A large number of simulation comparison experiments has been conducted on the Cloudsim platform. The experimental results show that the improved particle swarm optimization algorithm has better performance in adaptability, convergence speed, and capabilities of finding global optimums.
2022-12-10T01:20:31.331Z
44,828,511
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1200/jco.2009.27.15_suppl.8091", "MAG": "2970527692", "PubMedCentral": null }, "license": null, "status": null, "url": null }
8091 Background: Signaling of Insulin like Growth Factors (IGFs) through the IGF type 1 receptor (IGF-IR) induces tumor resistance to cancer therapy. Bioavailability of IGFs is regulated by IGF-binding proteins (IGFBP), of which IGFBP3 is the most abundant. Figitumumab (F) (CP-751,871), a specific IGF-IR inhibitor, has shown phase 2 activity in NSCLC in some histologies (i.e., squamous cell and adenocarcinoma) but not others (i.e, large cell or NOS tumors). METHODS Protein expression of members of the IGF-IR pathway, EGFR and differentiation markers was determined in core biopsies from 230 NSCLC pts, including 52 pts enrolled in F trials. Plasma concentration of IGF-1 and related proteins was determined in 159 NSCLC pts in F trials. Gene expression profiling was conducted in 35 NSCLC cell lines treated with F. RESULTS Squamous NSCLC had the highest IGF-IR expression (p=0.057). An association with better outcome was seen for E-cadherin expression (HR =0.62, 0.46-0.82 95% CI, p=0.005) and clustering by E-cadherin levels revealed a strong correlation between IGF-IR and EGFR expression in the high E-cadherin group (p<0.001). This subset included 73% of the squamous cell tumors investigated (N=44). Plasma levels of free IGF-1 (fIGF-1) were low and not predictive of response in squamous cell. In contrast, pts with adenocarcinoma had high plasma fIGF-1 levels (p=0.06) that correlated with vimentin expression (Rho=0.732, p=0.06), and both fIGF-1 and vimentin were predictive of F clinical benefit (p=0.03). Large cell/NOS NSCLC expressed the highest levels of vimentin (p<0.001) but had low E-cadherin and IGF-IR expression and low fIGF-1 plasma levels. Analysis of anchorage independent growth in NSCLC cell lines confirmed that F activity is independently associated to IGF-IR overexpression (p=0.02) and IGFBP3 under-expression (p=0.009). CONCLUSIONS IGF-IR overexpression and increased free IGFs/low IGFBP are key independent mechanisms of sensitivity to F in NSCLC of squamous and adenocarcinoma cell histologies. [Table: see text] [Table: see text].
2022-12-12T22:17:06.128Z
200,193,267
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.31866/2410-1176.40.2019.172696", "MAG": "2962828825", "PubMedCentral": null }, "license": "CCBY", "status": "GOLD", "url": "http://arts-series-knukim.pp.ua/article/download/172696/173938" }
Метою статті є історіографічний аналіз навчально-методичної літератури з техніки виконання та особливостей викладання європейських та латиноамериканських танців міжнародного стилю у мистецтвознавчому контексті; простежити етапи формування технічних аспектів виконання бального танцю та висвітлити сучасні напрацювання згідно з виданнями Міжнародної асоціації вчителів танцю (IDTA), Імперської спілки вчителів танцю (ISTD) та Всесвітньої федерації танцювального спорту (WDSF). Методологія дослідження. У дослідженні використано органічна сукупність базових принципів дослідження: об’єктивності, історизму, багатофакторності, системності, комплексності, розвитку та плюралізму. Крім того, застосовано методи наукового пізнання: проблемно-хронологічний, конкретно-історичний, статистичний, описовий, логіко-аналітичний. Наукова новизна статті полягає у визначенні головних засад формування технічних аспектів виконання та особливостей викладання європейських та латиноамериканських танців міжнародного стилю протягом ХХ ст. та на сучасному етапі. Висновки. У результаті проведеного аналізу техніки виконання та особливостей викладання європейських та латиноамериканських танців міжнародного стилю, розглянуто етапи формування технічних аспектів виконання бального танцю протягом ХХ ст., удосконалення систематизації методичних рекомендацій та технічних положень, зміни та доповнення внесені у найавторитетніші видання, згідно зі змінами затвердженими Комітетами європейських та латиноамериканських танців Імперського товариства вчителів танцю (ISTD), Міжнародною асоціацією вчителів танцю (IDTA), Всесвітньою радою танцю (WDC), Альянсу Сполученого Королівства (UKA) та Всесвітньої федерації танцювального спорту (WDSF) у процесі еволюціонування бального танцю.
2022-12-12T11:27:59.828Z
22,615,951
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1080/10731190902742489", "MAG": "2128056821", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The glutathione-s-transferases are a family of multifunctional enzymes involved in the detoxification of electrophilic xenobiotics primarily through conjugation to reduce glutathione. A form of the enzyme, designated GSH-S transferase ρ, was purified chicken erythrocyte by acetone precipitation, ethanol-chloroform treatment, DEAE-Cellulose, Q-Sepharose, Sephadex G-100 chromatography. The molecular weight of GST purified from chicken erythrocyte was estimated as 47,500 Da by gel filtration. The subunit molecular weight of chicken erythrocyte GST as determined by electrophoresis in the presence of sodium dodecyl sulfate was predicted as 24,000 Da. The specific activity was found to be 20.39 U/mg. The km for CDNB calculated from Lineweaver-Burk plot was 0.71 mM. Optimum temperature of maximum GST activity was 28°C for CDNB. The maximal activity of the enzyme was observed at pH 7.5. The activity of purified GST is inhibited by DDT, urea, CDNB, Triton X-100, DTNB.
2022-12-12T12:43:10.803Z
60,511,958
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.4028/www.scientific.net/AMR.562-564.1912", "MAG": "1970757577", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Aimed at the problem that video image is often affected by noises, the principle of median filtering and improved algorithm is analyzed. A new algorithm of noise elimination is presented, whose experiment on video processing hardware shows its reliability and advantage: image noise can be removed and image details can be preserved effectively.
2022-02-11T15:50:54.092Z
147,307,362
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1097/01.cnj.0000305999.35370.99", "MAG": "2271408207", "PubMedCentral": null }, "license": null, "status": "BRONZE", "url": "https://journals.lww.com/journalofchristiannursing/Fulltext/2008/01000/Conflicts_at_Work___try_Care_fronting.4.aspx" }
There are two basic understandings of conflict: the pluralistic view and the conceptions based on the research of human relations. Pluralists have a positive view of conflict. They consider it to be inevitable, and even a desirable phenomenon. Conflict is found at the essence of all things. They follow all societal occurrences, processes and relationships. Researchers of human relations consider conflict to be a negative phenomenon and do not find them inevitable. Further, conflict violates normal, 'healthy' human relations. This is why it is necessary to avoid, to prevent and to resolve it as soon as possible.
2022-09-16T02:42:30.907Z
119,435,127
{ "externalids": { "ACL": null, "ArXiv": "cond-mat/9408098", "DOI": "10.1103/PhysRevB.51.5048", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
One-particle eigenstates and eigenvalues of two-dimensional electrons in the strong magnetic field with short range impurity and impurities, cosine potential, boundary potential, and periodic array of short range potentials are obtained by magnetic von-Neumann lattice in which Landau level wave functions have minimum spatial extensions. We find that there is a dual correspondence between cosine potential and lattice kinetic term and that the representation based on the von-Neumann lattice is quite useful for solving the system’s dynamics.
2022-09-20T16:33:17.782Z
143,222,150
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.12930/0271-9517-26.1.56", "MAG": "1969405575", "PubMedCentral": null }, "license": null, "status": "BRONZE", "url": "https://meridian.allenpress.com/nacada-journal/article-pdf/26/1/56/2224819/0271-9517-26_1_56.pdf" }
We designed this study to understand academic advising at an urban university from diverse student perspectives. Based on a review of the advising literature, we identified 12 functions of academic advising and surveyed 2,100 undergraduates to address the following questions: Which of these advising functions are most important to students? How satisfied are students with the advising they receive on these functions? Do student characteristics impact importance and satisfaction ratings? Results show that students rated all functions as highly important, but satisfaction with advising was not commensurate with the importance students attached to it. In general, student characteristics (gender, ethnicity, financial need, age/cohort, enrollment status, and class level) influenced perceived importance of, but not satisfaction with, advising functions. Relative emphasis: *theory, research, practice
2022-12-25T04:20:33.459Z
170,879,405
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.22409/RBCV.V14I3.432", "MAG": "2522086707", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Foram avaliadas, quanto as caracteristicas microbiologicas, as carnes mecanicamente separadas de aves oriundas de doisprocessos de obtencao. Para o produto obtido no Processo 1 (processamento dos dorsos, ossos do peito e pescocos aposdesossa manual de carcacas pre-resfriadas entre 7 e 10oC em continuidade ao processo de abate), os valores medios dacontagem padrao de mesofilos e psicrotroficos foram de 1,2 x 105UFC/g e 1,4 x 105UFC/g, respectivamente; para bolores eleveduras, 7,2 x 102 UFC/g e Staphylococcus aureus, 2,3 x 102UFC/g. Para o NMP de coliformes totais, coliformes fecais eEscherichia coli, foram de 5,2 x 103/g, 3,0 x 103/g e 2,1 x 103/g respectivamente, sendo 27,5% de amostras positivas paraSalmonella spp. Para o produto obtido no Processo 2 (processamento dos dorsos, ossos do peito e pescoco resfriados entre0o e 2oC, em tunel de congelamento), os valores medios da contagem padrao de mesofilos e psicrotroficos foram de 1,1 x105UFC/g, para bolores e leveduras 6,7 x 102UFC/g e Staphylococcus aureus 2,8 x 102UFC/g. Para NMP de coliformes totais,coliformes fecais e E. coli foram 3,1x 103/g, 1,8 x 103/g e 1,4x 103/g, respectivamente, e 25,0% das amostras se mostrampositivas para Salmonella spp. O processo 2 mostrou um numero mais reduzido de microrganismos (com excecao do S.aureus), mas a diferenca entre as medias mostrou-se nao-significativa (P > 0,05), indicando que a desossa mecânica, deforma ininterrupta a desossa manual, mesmo com um produto com temperaturas mais elevadas, mostrou-se adequada. Osvalores encontrados sao semelhantes aos relatados na literatura, em carne mecanicamente separada de aves e estao abaixodos valores maximos permitidos pela legislacao em relacao aos microrganismos potencialmente patogenicos.
2022-02-08T17:06:53.464Z
34,918,347
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1520/JFS14275J", "MAG": "65189691", "PubMedCentral": null }, "license": null, "status": null, "url": null }
A series of validation experiments were designed to evaluate, according to the Technical Working Group on DNA Analysis Methods (TWGDAM) guidelines, the analysis of the D1S80 locus for casework implementation. Approximately 400 samples from three different populations (Minnesota Caucasian, Minnesota African Americans, and Minnesota Native Americans) were typed to determine allele frequencies. Simulated forensic type specimens (blood, saliva, hair and semen, or vaginal secretions) were typed to demonstrate that deoxyribonucleic acid (DNA) extracted from various tissues of an individual yield the same D1S80 type. Dilution studies were performed and it was determined that a wide range of input DNA (0.5 ng to 40.0 ng) will consistently yield typeable results. The evaluation of DNA from various animals showed that the D1S80 locus is specific to human DNA within the limits of the parameters tested. The reproducibility of the system was tested by duplicate analysis of approximately 200 population samples. Duplicate samples were analyzed on both horizontal and vertical gel systems. In addition, simulated forensic specimens were analyzed by two independent laboratories: the Minnesota Forensic Science Laboratory (MFSL) and the Roche Biomedical Laboratories (RBL). All analyses, including extraction, quantitation, amplification and typing, were performed independently. All typing results for both laboratories were in agreement. By the analysis of mixtures from various simulated casework type mixtures, it was demonstrated that the D1S80 typing system is suitable for analyzing mixtures. In addition to the simulated casework, evidentiary samples from several adjudicated cases previously analyzed by restriction fragment length polymorphism (RFLP) analysis and/or DQA1 were typed at the D1S80 locus. The D1S80 results were consistent with previous RFLP and/or DQA1 results regarding inclusions/exclusions.
2022-03-04T01:22:53.572Z
246,735,359
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1785/0220210304", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
Beginning on 30 June 2021, hundreds of earthquakes were detected beneath Semangko Bay in southernmost Sumatra, which is located adjacent to the Sunda Strait, a narrow sea passage that separates the islands of Java and Sumatra. A number of these earthquakes were large enough to be felt by people living in the city of Lampung, some 100 km to the east. In terms of magnitude and temporal distribution, the earthquakes did not follow a typical mainshock–aftershock sequence because the onset was marked by a cluster of five earthquakes with local magnitudes that ranged between 4.2 and 4.6, followed by a rapid decay in the number of detected events. We have relocated 254 of the 258 earthquakes that were recorded between 30 June and 14 July 2021, with a local magnitude range between ML 0.9 and 4.6, using the double-difference relocation method (hypoDD); focal mechanisms were also determined for a subset of events with a magnitude >4. Our results show that the seismicity pattern and focal mechanism solutions are more consistent with a multiple event episode caused by the rupture of several antithetic faults that have a similar strike to the west Semangko fault in southernmost Sumatra rather than a single fault plane. These faults appear to be part of a small graben system located beneath Semangko Bay, which was likely activated by ongoing extension in the Sunda Strait.
2022-08-09T07:37:31.300Z
62,733,147
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1109/ICASSP.1991.150169", "MAG": "2074944415", "PubMedCentral": null }, "license": null, "status": null, "url": null }
High-resolution direction finding algorithms applied to circular array structures are discussed. Uncalibrated direction finding algorithms yield highly biased direction-of-arrival estimates due to strong mutual coupling effects among array elements. Alternate array response models based on array geometry and electromagnetic characteristics of sensors are derived. The array output generated by these models is used to calibrate direction finding algorithms. This method is applied to MUSIC algorithm and its performance is simulated. This approach exhibits superior estimation performance compared to the standard MUSIC algorithm.<<ETX>>
2022-09-07T03:33:02.701Z
15,594,831
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1093/IJE/DYU209", "MAG": "2142793242", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The international scientific literature reports no data on the prevalence and effectiveness of back protector devices (BPD). In Italy, no data have been collected on BPD because their use is not mandatory. To fill this gap, the National Institute of Health implemented a cross-sectional study in collaboration with the National Traffic Police.Accident cases were collected from 1 December 2011 to 25 October 2013. Overall, data from 2104 accidents involving 2319 injured subjects were analysed: 1821 (78.5%) of these were motorcyclists and 498 (21.5%) mopedists. The use of Hard-shell BPD or jackets with airbags in motorcyclists is higher then in moped drivers (16.2% vs 1.3%,P¼0.000). Concerning level of protection, there are no differences between drivers and passengers. In most severely injured motorcyclists (i.e. hospitalized or deceased), the percentage of injuries to the spine was lower (13.6%) among those who used a high level safety device (hard-shell BPD and/or airbags) and rose to 27.3% among those who used only protective clothing (P¼0.022). When the variables potentially affecting the results of not using a high-safety device were controlled, a bivariate analysis showed that the odds of serious spinal injury were 2.72 times greater (P¼0.049) and a multivariate analysis showed that they were 2.81 times greater (P¼0.012). This study points out that greater use of BPD could reduce the number of injuries to the spinal column resulting from road traffic accidents involving motorized two-wheeled vehicles.
2022-09-08T01:27:35.551Z
46,728,131
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/j.1478-3231.2007.01472.x", "MAG": "2013838770", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Background/Aims: Patients with coagulation factor disorders require lifelong symptomatic treatment. This is associated with limited efficacy and transmission risks. From a clinical point of view, hepatocyte transplantation offers a rational alternative but is currently being hampered by lack of functional stability of engrafted cells. It was the aim of our study to devise culture conditions providing stable cell polarity, attachment and growth factor stimulation to improve longevity and coagulation factor production.
2022-09-13T22:15:31.809Z
84,931,048
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/J.1537-2197.1922.TB05669.X", "MAG": "2080543625", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Secondary growth in the woody stems of gymnosperms and angiosperms often results in the formation of annual rings in the xylem, but in the phloem no similar arrangement of elements is usually to be observed. The sieve tubes, which are generally the principal elements of the phloem, are crushed at the end of each period of growth by the pressure of surrounding cells and tissues. To these changes taking place in the secondary phloem the term obliteration has been applied for a long time. The alterations are initiated by the disappearance of the contents of the sieve tubes at the end of each growth period, soon followed by a crushing and distortion of the sieve tubes, and, in the case of angiosperms, of companion cells also. The sieve plates may be broken down, and the wall of the sieve tube takes on a swollen appearance. In an advanced condition of obliteration, the lumen of the sieve tube entirely disappears, being represented only by a line, and the whole mass of crushed sieve tubes takes on a horn-like consistency. During these changes the structure of the phloem parenchyma does not appear to be affected. The term horn prosenchym (Horngewebe) was applied by Wigand (I863) to such a mass of crushed tissue. The principal facts concerning the transformations undergone by the phloem of woody angiosperms have been generally known since the time of this writer. Previous to this date both -Oudemans (I862) and Rauwenhoff (I869) appear to have described obliterated structures in the phloem, Oudemans in I855, and Rauwenhoff in I859. These two writers, together with Moeller (I875) and Tschirch (I889), showed the crushed tissue to be composed of obliterated sieve tubes. Tschirch pointed out that the sieve tubes, including cambiform cells and companion cells, having lost the principal portion of their contents at the end of the growing season, become pressed together through the turgor of neighboring cells, so that only a small, cleft-shaped lumen remains. He believed that a subsequent thickening of the wall does not take place. De Bary (I884) indicated some doubt as to the extent to which the cambiform cells of the phloem are affected in obliteration, although he described the crilshing of the sieve tubes. Bliesnick (I89I) found that the phloem parenchyma takes no part in obliteration. His conclusions are essentially the same as those of Tschirch with regard to the causes of obliteration. Lignification of sieve plates was found in Clematis, and in another case he mentions that he found complete lignification of the obliterated phloem elements. His results differ from those of previous investigators in that 239
2022-12-18T00:45:02.236Z
209,938,755
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1029/2019SW002321", "MAG": "2981525471", "PubMedCentral": null }, "license": null, "status": null, "url": null }
One of the major research areas in the space weather community is the ability to understand, characterize, and model a time‐space variant ionosphere through which transionospheric signals propagate. In this paper a strong constraint four‐dimensional variational data assimilation (4D‐var) technique was used to more accurately estimate the South African regional ionosphere (bound latitude 20–35°S, longitude 20–40°E, and altitude 100–1,336 km). The altitude was capped to the JASON‐1 satellite orbital altitude for the purpose of eliminating the plasmasphere contribution hence reducing the computation expense. Background densities were obtained from an empirical internationally recognized ionosphere model (IRI‐2016) and propagated in time using a Gauss‐Markov filter. Ingested data were STECs (slant total electron content) obtained from the South African Global Navigation Satellite System receiver network (TrigNet). The vertically integrated electron content was validated using Global ionosphere Maps and JASON‐3 data over the continent and ocean areas, respectively. Further, vertical profiles after assimilation were compared with data from a network of ground‐based regional ionosondes Hermanus (34.25°S, 19.13°E), Grahamstown (33.3°S, 26.5°E), Louisvale (21.2°S, 28.5°E), and Madimbo (22.4°S, 30.9°E). Results show that assimilation of STEC data has a profound improvement on the estimation of both the horizontal and vertical structures during quiet and storm periods. Accuracy of the horizontal structure decreases from the continent toward the ocean area where GPS receivers are less abundant. Superiority of assimilating STEC is best pronounced during daytime especially when estimating maximum electron density of the F2 layer (NmF2), with a 60% root‐mean‐square error improvement over the background values.
2022-12-30T01:05:09.002Z
165,122,257
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1210/JS.2019-SAT-251", "MAG": "2944302015", "PubMedCentral": "6552053" }, "license": null, "status": null, "url": null }
Abstract Background Many studies show a correlation between short sleep duration and obesity/insulin resistance. One hypothesis for this association is that shortened sleep causes increased energy intake (EI). In some studies, experimentally reduced sleep duration has been found to increase total EI. There are mixed findings about the effects of habitual and acute short sleep on the macronutrient content of consumed meals. Additionally, there are few pediatric studies with objectively measured sleep duration (e.g. using actigraphy). Therefore, we aimed to determine if an acute sleep change was associated with greater total EI, altered macronutrient intake, or altered insulin sensitivity in children. Methods Healthy weight and overweight volunteers (n=18, 44% male), aged 7-11 years wore ActiGraph activity monitors for six consecutive 24 hour periods to determine nightly sleep duration. Volunteers were given no direction regarding sleep for the week. On day six, children underwent a standardized oral glucose tolerance test (OGTT) (1.75g/kg, max 75g) after which total EI (kcal) and macronutrient composition (% of total EI) were measured during a lunchtime laboratory test meal (>10,000 kcal; ~12% protein, 32% fat, 56% CHO). Subjects were directed to eat as much as they wanted. Acute change in sleep was calculated by subtracting each participant’s average nightly total sleep time over the entire week from their total sleep time on the fifth night (i.e., night before the test meal). Linear regressions examined associations of acute change in sleep with insulin AUC during OGTT, total EI, % CHO, % fat, and ratio of %CHO to %fat intake. Results Controlling for daily predicted energy needs and physical activity level, acute change in sleep (mean of 27.5 minutes less than average) was not significantly associated with total EI (p=0.58). However, the %CHO trended toward a significant negative correlation (r=-0.47, p=0.05) and %fat was positively associated (r=0.50, p=0.036) with acute change in sleep such that the %CHO to %fat intake ratio was greater in those with greater sleep deficit (p=0.039). Additionally, controlling for BMI-z score, basal insulin, and age, greater sleep deficit was associated with increased insulin AUC during the OGTT (p=0.001). Discussion Contrary to some previous experimental data, acute sleep deficit had no significant association with total EI; however, acute sleep deficit was associated with increased relative carbohydrate intake. Acute sleep deficit was also associated with decreased relative fat intake, a known satiating macronutrient. These data also suggest an acute decrease in insulin sensitivity associated with sleep deficit. All three mechanisms could explain or exacerbate the increased prevalence of obesity and metabolic abnormalities in children with short sleep duration and therefore, provide support for sleep-associated adjunctive treatment for such children.
2022-02-08T20:08:07.162Z
235,452,419
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1155/2021/9956406", "MAG": null, "PubMedCentral": null }, "license": "CCBY", "status": "GOLD", "url": "https://downloads.hindawi.com/journals/jece/2021/9956406.pdf" }
Taxi flow is an important part of the urban intelligent transportation system. The accurate prediction of taxi flow provides an attractive way to find the potential traffic hotspots in the city, which helps to avoid serious traffic congestions by taking effective measures in advance. The current prediction of taxi flow and its impact on urban transportation are closely related to the passenger origin-destination (OD) information. However, high-quality OD information is not always available. To address this problem, a prediction model, named as TaxiInt, is proposed in this study. Different from other density-clustering-based approaches, neural network, or OD information based models, TaxiInt predicted the taxi flow using the trajectory data of taxis. The spatial features and temporal features of each road were extracted using a graph convolutional network, which was trained with the road network information and the trajectory data. The experiments carried on a real taxi dataset showed the validity of our model. It can predict the taxi flow at a given urban intersection with high accuracy.
2022-08-20T17:41:20.463Z
151,360,093
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/JFTR.12169", "MAG": "2559982060", "PubMedCentral": null }, "license": null, "status": null, "url": null }
Our purpose is to apply Aristotelian theory to family studies. We introduce Aristotle's work through his debate with Plato over the meaning of family and its role in society. We then explain key concepts in Aristotelian theory, including virtue, practical wisdom, telos, interpretation and evaluation, agency, and human development. We propose an Aristotelian conceptualization of family as a multigenerational institution of mutual responsibility, defined in part through narrative and oriented around developing virtue and helping members reach their potential. Finally, we identify family virtues and consider implications of Aristotelianism for social research, with particular attention to how Aristotle's work provides an epistemological basis for narrative research in general and for case study research in particular.
2022-09-12T03:48:24.459Z
221,359,192
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1021/acschembio.0c00526", "MAG": "3081685638", "PubMedCentral": null }, "license": null, "status": null, "url": null }
A new linear type 1 polyketide, ionostatin (1) has been fully defined using a combined genomic and bioinformatics approach coupled with confirmatory chemical analyses. The 41 carbon-containing polyether is the product of the 101 kbp ion biosynthetic cluster containing seven modular type 1 polyketide synthases. Ionostatin is composed of 15 chiral centers that were proposed using the stereospecificities installed by the different classes of ketoreductases and enoylreductases and confirmed by rigorous NMR analysis. Incorporated into the structure are two tetrahydrofuran rings that appear to be the product of stereospecific epoxidation followed by stereospecific ring opening and cyclization. These transformations are proposed to be catalyzed by conserved enzymes analogous to those found in other bacterial-derived polyether biosynthetic clusters. Ionostatin shows moderate cancer cell cytotoxicity against U87 glioblastoma and SKOV3 ovarian carcinoma at 7.4 μg/mL.
2022-12-02T17:26:53.018Z
216,486,020
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.3390/catal10030346", "MAG": "3012053413", "PubMedCentral": null }, "license": "CCBY", "status": "GOLD", "url": "https://www.mdpi.com/2073-4344/10/3/346/pdf?version=1584712670" }
Ni catalysts supported on ZrO2, 5%CeO2-ZrO2, and 5%La2O3-ZrO2 were prepared via the impregnation method and tested in the oxy-steam reforming of methane and liquified natural gas (LNG). All tested catalysts exhibited high catalytic activity in the studied process at 700 and 900 °C. The improvement of the stability of Ni catalysts after the addition of CeO2 oxide in the studied oxy-steam reforming of LNG process was confirmed. In addition, high activity and selectivity towards hydrogen was proven in the oxy-steam reforming process at 900 °C over a 20%Ni/5%CeO2-ZrO2 catalyst. It was also proved that the addition of CeO2 onto a ZrO2 carrier leads to a decrease in the NiO and metallic Ni crystallite sizes that were detected by the X-Ray diffraction (XRD) technique. The solid solution formation between NiO and ZrO2 and/or NiO and CeO2 was proved. Superior reactivity in the oxy-steam reforming of CH4 and the LNG process exhibited a 20%Ni/ZrO2 catalyst, which showed the highest methane conversions at 500 and 600 °C, equal to 63% and 89%, respectively. In addition, also in the case of the LNG reforming reaction, the most active catalyst was the 20%Ni/ZrO2 system, which demonstrated 46.3% and 76.9% of the methane conversion value at 500 and 600 °C and the total conversion of others hydrocarbons (ethane, propane and butane). In addition, this catalytic system exhibited the highest selectivity towards hydrogen formation in the oxy-steam reforming of the LNG reaction equal to 71.2% and 71.3% at 500 and 600 °C, respectively. The highest activity of this system can be explained by the uniform distributions of Ni species and their highest concentration compared to the rest of the monometallic Ni catalysts. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) results also confirmed a strong interaction of NiO with ZrO2 in the case of the 20%Ni/ZrO2 catalysts. The presence of selected NiZrO+ ions emitted from the investigated surface of the 20%Ni/ZrO2 system was detected.
2022-12-02T10:36:23.068Z
220,336,115
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1111/dth.13965", "MAG": "3040386394", "PubMedCentral": null }, "license": null, "status": "GOLD", "url": "https://doi.org/10.1111/dth.13965" }
Dear Editor, Reactive arthritis (ReA) is a systemic inflammatory disease with varying chronicity. It is triggered by gastrointestinal or genitourinary infections (commonly Chlamydia trachomatis). Background genetic predisposition with HLA B27 is important for triggering the inflammatory response. Various cytokines are implicated in the pathogenesis including tumor necrosis factor alpha (TNFα), interleukin (IL)-6, IL-17, IL-22, and interferon-gamma. We report three cases of ReA who showed good response to adalimumab. All patients had initial joint complaints with progressively debilitating arthritis. There was a long time interval (more than a decade) between the initial articular and subsequent mucocutaneous manifestations. Their salient clinical and investigation findings are outlined in Table 1 (Figures 1-3). Histopathological features in all three cases revealed psoriasiform hyperplasia and superficial dermal perivascular infiltrate (Figure S1). The patients were initially treated with
2022-12-30T00:55:53.461Z
125,665,561
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1049/CP:20080389", "MAG": "2586454053", "PubMedCentral": null }, "license": null, "status": null, "url": null }
This paper presents an extracting method for the curves based on B-Snake. Firstly, the polyline is constructed from the points of nearby object curve by user input (It is a polygon under the closed condition).Then the all pixel points through the polyline are obtained rapidly by the DDA algorithm from which are sampled by fixed interval. The pixel points are initial Snake points namely. At last, the Snake points integrated closely the image curve are fitted by using B-spline. Compared to the classical snake model, the denser points can be obtained due to making use of DDA algorithm as well as by sampling at regular intervals for the pixel points through the polylines, consequently, the image target curves can be expressed more accurately and it is the basis for the accurate matching and 3D reconstruction in reverse engineering.
2022-02-09T16:40:24.487Z
29,942,152
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.5694/j.1326-5377.1950.tb106934.x", "MAG": null, "PubMedCentral": null }, "license": null, "status": null, "url": null }
Myocarditis is defined as inflammation of the myocardium accompanied by myocellular necrosis. Acute myocarditis must be considered in patients who present with recent onset of cardiac failure or arrhythmia. Fulminant myocarditis is a distinct entity characterized by sudden onset of severe congestive heart failure or cardiogenic shock, usually following a flu-like illness, parvovirus B19, human herpesvirus 6, coxsackievirus and adenovirus being the most frequently viruses responsible for the disease. Treatment of myocarditis remains largely supportive, since immunosuppression has not been proven to be beneficial for acute lymphocytic myocarditis. Trials of antiviral therapies, or immunostimulants such as interferons, suggest a potential therapeutic role but require further investigation. Lastly, early recognition of patients rapidly progressing to refractory cardiac failure and their immediate transfer to a medical-surgical center experienced in mechanical circulatory support is warranted. In this setting, ECMO should be the first-line mechanical assistance. For highly unstable patients, a Mobile Cardiac Assistance Unit, that rapidly travels to primary care hospitals with a portable ECMO system and hooks it up before refractory multiorgan failure takes hold, is the preferred option.
2022-07-01T02:07:03.420Z
9,621,989
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1136/oem.48.9.579", "MAG": "2099347923", "PubMedCentral": null }, "license": null, "status": "BRONZE", "url": "https://oem.bmj.com/content/oemed/48/9/579.full.pdf" }
The results from the first year of a notification scheme for occupational asthma in the West Midlands Region are presented. The scheme includes recognised new and old cases of occupational asthma. Thirty new cases were recognised per million general working population in the first year. Cases recognised in different occupational groups ranged from 154 per million painters and assembly workers to three per million clerical staff. Analysis of the agents to which workers with recognised occupational asthma were exposed identified commonly recognised agents such as isocyanates, colophony, and flour and generally less well recognised ones such as oil mists. The distribution of new and old reported cases, including those receiving compensation from the Department of Social Security, were calculated by health authority using estimated working population as the denominator. The number of reported cases varied from 303 per million in a semi-urban health authority that has a respiratory physician with a special interest in occupational asthma to less than 30 cases per million in eight health authorities. The most likely cause for these differences is lack of ascertainment.
2022-09-02T07:47:43.684Z
225,276,102
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.1002/admt.202000535", "MAG": "3081415595", "PubMedCentral": null }, "license": null, "status": "GREEN", "url": "https://hal.archives-ouvertes.fr/hal-03048907/file/paper_cugat_2020.pdf" }
Only achievable with two photons’ polymerization, 3D printing at the micrometer scale is essential for the fabrication of complex objects such as photonic components, deformable microstructures, or microscaffolds for biological cells. Integrating magnetic materials inside those structures has made their remote actuation with an external magnetic field possible. However, the nature of the magnetic material, its volume, and precise position in the structure are keys for the efficiency, dexterity, and compatibility with optical or biological functions. Herein, an original approach consisting in the bonding of discrete and fully magnetic microbeads to unaffected 3D‐microprinted structures is presented. Implemented in combination with the fine control of optical and mechanical properties allowed by the careful design of the 3D architecture, it is applied to the fabrication of the first remotely tunable biconvex microlens (focal length of 18 µm). Combined with the additional precise positioning and magnetic orientation of multiple microbeads, the presented technique enables the fabrication of complex actuators such as a 100 µm microtweezer that can be translated, rotated, and opened with a single variable external magnetic field. The dexterity of this untethered micromanipulator is demonstrated through a pick‐and‐place operation of 40 µm objects in a confined environment.
2022-12-30T00:55:53.310Z
234,809,619
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.18050/ESP.2014.V8I1.2717", "MAG": "3155279860", "PubMedCentral": null }, "license": null, "status": null, "url": null }
The negative effects of low academic performance in university students, as well as for higher education institutions in Mexico, today represents a problem to which an efficient solution has not been found for both; The present research aims at the correlation of cognitive and personality factors on academic performance in university students. Data that will allow the Educational Guidance departments of the universities to identify aspects in the students for their comprehensive support. Under the theoretical postulates of Clinical Psychology for the topic of personality, the postulates of Educational Psychology for the topic of cognitive functions and academic performance from the perspective that integrates pedagogy, psychology and sociology. The results allow to affirm the significant correlation that exists between DepressionGender and Depression-Concentration, Gender-Difficulty for work and Gender-Attention, Anxiety-Attention, Difficulty for work-Attention and Difficulty for work-Concentration.
2022-01-27T09:42:13.485Z
18,595,867
{ "externalids": { "ACL": null, "ArXiv": null, "DOI": "10.11650/TJM.19.2015.4044", "MAG": "2018018530", "PubMedCentral": null }, "license": null, "status": null, "url": null }
In this paper, we deal with the existence of infinitely many solutions for a class of sublinear Schrodinger equation $$ \left\{ \begin{array}{ll} -\triangle u+V(x)u=f(x, u), \ \ \ \ x\in {\mathbb{R}}^{N},\\ u\in H^{1}({\mathbb{R}}^{N}). \end{array} \right. $$ Under the assumptions that $\inf_{{\mathbb{R}}^{N}}V(x) >0$ and $f(x, t)$ is indefinite sign and sublinear as $|t|\to +\infty$, we establish some existence criteria to guarantee that the above problem has at least one or infinitely many nontrival solutions by using the genus properties in critical point theory.
2022-11-18T21:04:08.638Z