corpusid
int64 5
255M
| openaccessinfo
dict | abstract
stringlengths 1
10k
| updated
stringlengths 20
24
|
|---|---|---|---|
43,619,888 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/106286069901400404",
"MAG": "2074252305",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Although current literature supports the use of evidence-based clinical practice guidelines (CPGs) by physicians, there is limited research concerning operational issues that may be inhibiting effective CPG implementation. The objective of our research was to increase understanding of clinical practice patterns by identifying physician preferences for CPG accessibility, format, content and learning strategies. Semistructured interviews were conducted with resident and faculty physicians in an academic medical center after they were presented with a CPG during treatment of a patient with acute pancreatitis. The results of our study revealed that physicians prefer CPGs in the form of evidence-based algorithms with treatment-specific information that is placed on the front of the patient chart during treatment. In addition, they felt that discussion of the guideline with colleagues, reminder notes/stickers on front of the patient chart, and verbal reminders from a nurse were the most effective means of encouraging utilization.
|
2022-12-17T10:54:20.075Z
|
25,647,365 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3168/jds.2011-4578",
"MAG": "2050918106",
"PubMedCentral": null
},
"license": "elsevier-specific: oa user license",
"status": "BRONZE",
"url": "http://www.journalofdairyscience.org/article/S0022030211005522/pdf"
}
|
The aim of this review was to focus on the complex relationships between milk and dairy products intake and bone health, with particular emphasis on osteoporosis. The literature was extensively examined to provide an objective overview of the most significant achievements on the subject. Osteoporosis can be defined as a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk. Although the major determinants of peak bone mass and strength are genetic, major factors during childhood and adolescence may affect the ability to achieve peak bone mass. These include nutrition, particularly calcium and protein intake, physical activity, endocrine status, as well as exposure to a wide variety of risk factors. The role of calcium intake in determining bone mineral mass is well recognized to be the most critical nutritional factor to achieve optimal peak bone mass. The greatest amount of dietary calcium is obtained from milk and dairy foods, which also provide the human diet with vitamin D (particularly for products fortified with vitamin D), potassium, and other macro- and micronutrients. Although studies supporting the beneficial effects of milk or calcium on bone health are predominant in the literature, perplexity or discordance on this subject was expressed by some authors. Discordant data, mainly on the risk of fractures, provided limited proof of the unfavorable effect of dairy intake. More often, discordant works indicate no effect of dairy consumption on bone safety. Some considerations can be drawn from this viewpoint. Milk and dairy products are an optimal source of calcium as well as of other limiting nutrients (e.g., potassium and magnesium), with important effects on bone health. Bioactive components occurring in milk and dairy products may play an essential role on bone metabolism, as shown by in vivo and in vitro studies on colostrum acidic proteins and milk basic proteins. Calcium intake positively affects bone mass and is crucial in childhood and youth for correct bone development. In elderly people, calcium intake as well as vitamin D availability should be carefully checked. As a general conclusion, calcium is essential for bone health, although it will not prevent bone loss due to other factors; in this context, milk and dairy foods are bioavailable, relatively inexpensive sources of calcium for the human diet.
|
2022-12-18T23:36:04.713Z
|
12,746,928 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1172/JCI113521",
"MAG": "1988438945",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The effect of allogeneic bone marrow transplantation (BMT) was investigated in the neurologically affected twitcher mouse, a model for human Krabbe's disease. Twitcher mice have a hereditary deficiency of the lysosomal enzyme galactosylceramidase, which causes growth delay, tremor, and paralysis of the hind legs. Death occurs at 30-40 d of age. After BMT galactosylceramidase activity increased to donor levels in hemopoietic organs. In lung, heart, and liver, galactosylceramidase activity rose to levels intermediate between those of twitcher and normal mice. Increased galactosylceramidase activity in liver parenchymal cells indicated uptake of the donor enzyme by recipient cells of nonhemopoietic origin. Enzyme activity also increased in kidney tissue. BMT resulted in a gradual increase in galactosylceramidase activity in the central nervous system to 15% of normal donor levels. A 5-6-fold increase in galactosylceramidase activity was found in the peripheral nervous system. This increase in enzyme activity was accompanied by a partial alleviation of neurological symptoms. In particular, paralysis of the hind legs was prevented by BMT. BMT led to a modest restoration of growth and prolonged survival. In several cases, the mice survived for more than 100 d, but eventually all animals died with severe neurological disease.
|
2022-12-20T03:09:25.281Z
|
17,417,701 |
{
"externalids": {
"ACL": null,
"ArXiv": "astro-ph/0507468",
"DOI": "10.1086/462415",
"MAG": "2089421520",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://iopscience.iop.org/article/10.1086/462415/pdf"
}
|
The high-mass X-ray binary V0332+53 became active at the end of 2004, and the outburst was observed in hard X-rays by RXTE and INTEGRAL. Based on these hard X-ray observations, we measure the orbital parameters by fitting the Doppler-shifted spin periods. The derived orbital period and eccentricity are consistent with those obtained by Stella et al. from EXOSAT observations, whereas the projected semimajor axis and the periastron longitude are found to have changed from 48 ± 4 to 86 lt-s and from 313° ± 10° to 283° ± 14°, respectively. This would indicate an angular speed of ≥1.°5 ± 0.°8 yr-1 for the rotation of the orbit over the past 21 years. The periastron passage time of MJD 53,367 ± 1 is just around the time when the intensity reached maximum, and an orbital period earlier is the time when the outburst started. This correlation resembles the behavior of a type I outburst. During outburst, the source spun up at a rate of 8.01 × 10-6 s day-1. The evolution of the pulse profile is highly intensity dependent. The separation of double pulses remained almost constant (~0.47) when the source was bright and dropped to 0.37 within 3 days as the source became weaker. The pulse evolution of V0332+53 may be correlated with a change in dominance of the emission between fan-beam and pencil-beam mechanisms.
|
2022-12-29T12:18:37.376Z
|
233,274,428 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15421/332009",
"MAG": "3129685207",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "http://jphe.dnu.dp.ua/index.php/jphe/article/download/99/92"
}
|
New nanostructured Fe25B17.5Co21.35Nb3.65Ni25Si7.5 high-entropy metallic glass is synthesized by dint of splat-quenching technique. The estimated cooling rate is ~10 K/s. The coherently scattering domain size (crystallite size) of films of Fe25B17.5Co21.35Nb3.65Ni25Si7.5 high-entropy metallic glass estimated by the Sherer formula is ~ 3 nm. The high-entropy metallic glass shows a high temperature of glass transition Tg ~ 800 K and the initial temperature of crystallization Tx ~ 863 K. After annealing to ~ 1010 K (above the crystallization temperature) and subsequent slow cooling, the amorphous films crystallize with the formation of several crystalline phases. The temperature dependencies of electrical resistivity of the Fe25B17.5Co21.35Nb3.65Ni25Si7.5 films indicate the occurrence of phase transformations. The phase transformation temperature (temperature of crystallization) is ~ 869 K. This value agrees well with the value obtained from the differential thermal analysis.
|
2022-01-27T01:31:33.926Z
|
236,361,238 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12795/PPA.2021.I24.03",
"MAG": "3165286463",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article seeks to expand understanding of architectural design techniques, linking them to an “ecology of the invisible”: the attention to qualitative variables existing in the context, barely perceptible and often dismissed by value regimes in place. Following the economic-financial crisis, this procedure - which could be traced to architectural design throughout history - has acquired a new value, as a critique of the development models which predominated at the turn of the century, and also hindering its understanding. To clarify this point, we discuss the keys of this procedure in three projects pre-dating the crisis: Cedric Price’s proposal for the Design of Cities contest in Manhattan (1998), as well as the remodelling of Leon Aucoc Square (1996), and the School of Business Administration (2006), both in Bordeaux and by Lacaton & Vassal. While the first two have been interpreted as forms of “non-intervention” associated with a renunciation of design and construction, the last case has not, leading us to reconsider these examples in a propositional manner. The analysis methodology focuses on projects and how they have been shaped across channels and for different audiences, from specialized journals to the “poor images” shared in map server web applications. This analysis highlights the crucial role of editing, which subsequently guides architectural practices by prioritizing certain discourses over others
|
2022-07-08T02:20:57.500Z
|
128,711,935 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/1755-6724.12091",
"MAG": "2095629321",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In order to understand the origin and flow of formation water and to evaluate the hydrocarbon accumulation and preservation conditions, the properties of formation water chemistry and dynamics of the Zhenwu area in the southern Gaoyou Sag, North Jiangsu Basin, China, have been investigated. The results show that Xuzhuang oilfield is infiltrated discontinuously by meteoric water under gravity, which consequently leads to the desalination of formation water. Formation water in the Zhenwu and Caozhuang oilfields is less influenced by meteoric water infiltration, and the origin is interpreted to be connate water. Hydrocarbon migration, accumulation and preservation are closely related to the hydrodynamic field of formation water. Formation water concentrates gradually during the process of centrifugal flow released by mudstone compaction and the centripetal flow of meteoric water infiltration, leading to the high salinity of the central part. The geological conditions of the southern fault–terrace belt are poor for hydrocarbon accumulation and preservation as meteoric water infiltration, leaching and oxidation, while the central part, i.e., northern Zhenwu and Caozhuang oilfields is beneficial for an abundance of hydrocarbon accumulation. Most of the large scale oil–gas fields locate herein.
|
2022-11-04T20:38:45.682Z
|
233,554,856 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/D0TA10277F",
"MAG": "3148113789",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The starting stoichiometry of 2D/3D (PEA0.08FAxSnI3) tin perovskite films influences their crystallization and photophysical properties as well as the solar cell performance.
|
2022-12-02T10:38:54.343Z
|
43,885,436 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3109/08982100903544151",
"MAG": "1997765307",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The success of lipid membranes as cytotoxic T-cell (CTL) adjuvants requires targeted uptake by antigen-presenting cells (APCs) and delivery of the antigen cargo to the cytosol for processing. To target the phosphatidylserine (PS) receptor of APCs, we prepared antigen-loaded liposomes containing dipalmitoylphosphatidylserine and archaeal lipid liposomes (archaeosomes), containing an equivalent amount of archaetidylserine, and compared their ability to promote short and long-term CTL activity in animals. CTL responses were enhanced by the incorporation of PS into phosphatidylcholine/cholesterol liposomes and, to a lesser extent, into phosphatidylglycerol/cholesterol liposomes, that correlated to the amount of surface amino groups reactive with trinitrobenzoyl sulfonate. Archaeosomes contrasted to the liposome adjuvants by exhibiting higher amounts of surface amino groups and inducing superior shorter and, especially, longer-term CTL responses. The incorporation of dipalmitoyl lipids into archaeosomes induced instability and prevented long-term, but not short-term, CTL responses in mice. The importance of glycero-lipid cores (isopranoid versus dipalmitoyl) to the longevity of the CTL response achieved was shown further by incorporating dipalmitoyl phosphatidylethanolamine (DPPE) or equivalent amounts of synthetic archaetidylethanolamine (AE) into archaeosome adjuvants. Both DPPE and AE at equivalent (5 mol%) concentrations enhanced the rapidity of CTL responses in mice, indicating the importance of the head group in the short term. In the longer term, 5% of DPPE (but not 5% of AE) was detrimental. In addition to head-group effects critical to the potency of short-term CTL responses, the longer term CTL adjuvant properties of archaeosomes may be ascribed to stability imparted by the archaeal isopranoid core lipids.
|
2022-12-17T21:47:04.829Z
|
55,910,889 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4103/0250-474X.22976",
"MAG": "2017504544",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The present study was aimed to evaluate the wound healing activity of extract of tuber parts of Cyperus rotundus . It is a well-known plant in Indian traditional medicine. On the basis of traditional use and literature references, this plant was selected for evaluation of wound healing potential. An alcoholic extract of tuber parts of Cyperus rotundus was examined for wound healing activity in the form of ointment in three types of wound models on rats: the excision, the incision and dead space wound model. The extract ointments showed considerable difference in response in all the above said wound models as comparable to those of a standard drug nitrofurazone ointment (0.2% w/w NFZ) in terms of wound contracting ability, wound closure time and tensile strength.
|
2022-12-27T15:05:51.697Z
|
226,035,607 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5194/egusphere-egu2020-22335",
"MAG": "3084096946",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The impact of ENSO (El Niño Southern Oscillation) events on the cyclogenesis of the eastern tropical North Atlantic is highlighted, focusing on decadal variations of the interannual relationship at the Senegalese coast, which is the main cyclone development region (MDR). SST anomalies in the Equatorial Pacific associated with ENSO events affect vertical wind shear over the eastern Atlantic, by inducing strong subsidence of dry air over the eastern Atlantic which tends to inhibit deep convection and thus be unfavorable to cyclonic activity. Based on 20yrcorrelations between the number of cyclones that are born in the MDR and ENSO index, we have selected two different periods of study (period1: 1950-1969; and period2: 1996-2015).The results show that period2 presents the highest scores of negative correlations between ENSO and tropical Atlantic cyclogenesis. Although there is an intensification of ENSO events during period2 compared to period1, we have found that decadal changes in climatology have a more significant effect on the MDR than the interannual changes. Additionally, the changes in the interannual signal appear to be related to the concomitant action of interannual SST anomalies over the whole tropical basins.
|
2022-01-27T01:56:49.662Z
|
238,990,483 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/den.14146",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/den.14146"
}
|
This paper outlines what the Japan Gastroenterological Endoscopy Society (JGES) has done in terms of regulatory science for the development and spreading of gastrointestinal endoscopy and related medical devices. Since 2015, JGES had established an industry – government – academia social gathering and held regular meetings for the purpose of promoting research and development and commercialization of gastrointestinal endoscopes and related devices. At this social gathering, industry, regulatory agencies, and academia were able to understand their respective positions and share their problems. This became one of the contributions to the development of gastrointestinal endoscopic medicine. This social gathering com-pleted in 2018, and then JGES focused on the issues of endoscopic device development using arti fi cial intelligence (AI).
|
2022-05-07T06:03:38.174Z
|
57,626,015 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4103/1658-600X.179827",
"MAG": "2315820056",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Cataract surgery is one of the safest and most effective surgeries, but irreversible blindness may occur as a complication. Also, the visual outcome of cataract surgery can be affected by preoperative patients' comorbidities. The aim of this study was to assess the visual outcome and identify the complications of cataract surgery. Patients and Methods: This was a retrospective cross-sectional study. It included all patients who had undergone cataract surgery at King Abdulaziz Medical City, Riyadh, from January 2014 to June 2014. All data variables were managed and analysed using SPSS software. Data security and confidentiality were ensured throughout all stages of the study process. Results: A total number of 421 cataract surgeries were reviewed. There were 219 (52%) males and 198 (48%) females. The patients' age ranged between 34 to 94 years with an average age of 66 ± 11 years. Among 421 eyes, 187 (46%) gained a visual acuity of 20/40 or better and another 119 (29%) had 20/50 - 20/80 after the surgery. Intraoperative or postoperative complications were presented in 20 (5%) patients. The main causes for rendering the eyes from achieving the visual acuity of 20/40 or better were diabetic retinopathy, age-related macular degeneration and glaucoma. Conclusion: Cataract removal is a safe and effective surgery which can improve the quality of life. It has some complications that can be minimised with good pre-operative evaluation and post-operative rehabilitation.
|
2022-06-04T05:55:36.500Z
|
246,335,578 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15544/rd.2021.064",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://ejournals.vdu.lt/index.php/rd/article/download/2924/1954"
}
|
The economic growth has resulted in the depletion of natural resources and degradation of ecosystems. Therefore, the environmentally sustainable growth was accepted as a new model for economy. The idea of environmentally sustainable growth has been widely discussed not only by experts in environmental economics, but also in the international and national policy scene. However, the measurement of environmentally sustainable growth still remains a challenge, especially in agriculture. This article aims to provide an overview of detailed information on adaptation of total factor productivity (TFP) for the measurement of environmentally sustainable growth in agriculture. A method of literature overview was used. Our findings indicate that there are different approaches for performing environmentally sustainable growth measurement in agriculture, and the total factor productivity (TFP) and its modifications are most commonly used indicators in last years. Green TFP growth or similar environmentally related its modifications are measured by growth accounting, data envelopment analysis and stochastic frontier analysis methods.
|
2022-08-11T21:43:03.479Z
|
37,611,752 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/MSE.2003.1205252",
"MAG": "2169135916",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper summarizes the content and application of the SEED2002 project. SEED2002 is a university/industry collaboration to enhance and reform the education in the field of semi-custom/full-custom ASIC design at the universities of Mannheim, Heidelberg and Kaiserslautern, Germany. With this project Cadence Design Systems enables us to teach leading-edge ASIC design using their most innovative products.
|
2022-09-09T09:20:08.920Z
|
233,282,529 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24018/CLINICMED.2021.2.1.13",
"MAG": "3133257107",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study evaluated the presence of radiolucid lesions in digital panoramic radiographs from the archives of the State University of Paraiba (UEPB) Diagnostic Imaging Clinic, performed in 2017. After surveying the radiographs performed by the service in that year, those with radiolucent lesions were selected, being excluded those with poor quality and with patient positioning errors. By means of a structured form, the characteristics observed in the radiographs were recorded by a single trained and calibrated observer. The analysis took place through descriptive statistics and all ethical aspects were respected. There was a low prevalence (14.2%) of radiographs with radiolucent lesions, which mainly affected young female patients. These lesions were small in size, located predominantly in the posterior periapical region of the mandible, with a unilocular aspect, being associated with a posterior tooth, mainly premolar. Inflammatory lesions were the most prevalent, with a presumptive diagnosis highlighting the predominance of abscesses followed by cysts/granulomas. The dentigerous cyst was the third most prevalent odontogenic lesion, occurring in its entirety in females. Odontogenic keratocysts and Stafne's bone cavity were also detected.
|
2022-09-09T19:05:19.363Z
|
24,559,843 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1034/J.1600-0501.1997.080503.X",
"MAG": "2053578754",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Recombinant human bone morphogenetic protein-2 (rhBMP-2) induced bone regeneration and osseointegration was evaluated in supraalveolar peri-implant defects in 5 beagle dogs. Alveolar bone was reduced 5 mm in height in mandibular premolar areas and the premolars were extracted. Three 10 mm titanium fixtures were placed 5 mm into each reduced alveolar crest, leaving 5 mm in a supraalveolar position. Alternate quadrants in consecutive animals received a surgical implant consisting of 2 ml rhBMP-2 (0.43 mg/ml) in a type I bovine collagen carrier, or the carrier alone (control). Fixtures and surgical implants were submerged under the gingival flaps. The healing interval was 16 weeks. Histometric and radiographic evaluations were made. Defect height averaged (+/- SD) 5.3 +/- 0.2 and 5.1 +/- 0.2 mm for rhBMP-2 and control defects, respectively (P > 0.05, n = 5, paired, t-test) Bone regeneration (height) averaged 4.2 +/- 1.0 and 0.5 +/- 0.3 mm for rhBMP-2 and control defects, respectively (P < 0.05). Bone regeneration (area) averaged 6.1 +/- 6.3 and 0.2 +/- 0.2 mm2 for rhBMP-2 and control defects, respectively (P > 0.05). Osseointegration within the confines of the defect averaged 19.1 +/- 10.1% and 8.2 +/- 4.6% for rhBMP-2 and control defects, respectively (P > 0.05). Osseointegration within regenerated bone averaged 29.1 +/- 9.8% and 65.3 +/- 15.3% for rhBMP-2 and control defects, respectively (P < 0.05). Osseointegration within the retained alveolar bone averaged 67.1 +/- 4.6% and 68.1 +/- 3.6% for rhBMP-2 and control defects, respectively (P > 0.05). The results suggest that there is a potential for rhBMP-2 induced bone regeneration and osseointegration in surgical peri-implant defects.
|
2022-09-15T06:00:18.519Z
|
121,028,359 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.4916431",
"MAG": "2006535569",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://aip.scitation.org/doi/pdf/10.1063/1.4916431"
}
|
Ion source rf antennas that produce H- ions can fail when plasma heating causes ablation of the insulating coating due to small structural defects such as cracks. Reducing antenna failures that reduce the operating capabilities of the Spallation Neutron Source (SNS) accelerator is one of the top priorities of the SNS H- Source Program at ORNL.Numerical modeling of ion sources can provide techniques for optimizing design in order to reduce antenna failures. There are a number of difficulties in developing accurate models of rf inductive plasmas. First, a large range of spatial and temporal scales must be resolved in order to accurately capture the physics of plasma motion, including the Debye length, rf frequencies on the order of tens of MHz, simulation time scales of many hundreds of rf periods, large device sizes on tens of cm, and ion motions that are thousands of times slower than electrons. This results in large simulation domains with many computational cells for solving plasma and electromagnetic e...
|
2022-11-11T08:15:42.142Z
|
120,372,358 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/03081080802648814",
"MAG": "1994852231",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We characterize all regular graphs whose second largest eigenvalue does not exceed 1. In the sequel, we determine all coronas, different from cones, with the same property. Some results and examples regarding unsolved cases are also given.
|
2022-12-03T13:41:49.894Z
|
244,305,470 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1742-6596/2015/1/012169",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/2015/1/012169"
}
|
The properties of screening effect for energy spectrum of excitons in monolayer transition metal dichalcogenides are investigated using a multiband model. The excitonic hamiltonian in the product base of the Dirac single-particle is used. The corresponding energy eigenvalue system of the first order ODE (radial equations) was solved using the finite difference method. This enables to determine the energy eigenvalues of the discrete excitonic spectrum and the wave functions. We compare the results for the energy spectrum and the corresponding eigen-functions forms for WS 2 and WSe 2 computed for two different potentials: pure Coulomb and screened Coulomb (Keldysh potential). It is demonstrated that excitonic energy levels for unscreened potential lie dipper, and the corresponding eigen-functions’ forms differ from those obtained for screened one.
|
2022-12-10T10:56:42.017Z
|
2,602,460 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1124/jpet.115.229997",
"MAG": "2215265314",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4767390?pdf=render"
}
|
B-type natriuretic peptide (BNP)–natriuretic peptide receptor A (NPRA) and gastrin-releasing peptide (GRP)–GRP receptor (GRPR) systems contribute to spinal processing of itch. However, pharmacological and anatomic evidence of these two spinal ligand-receptor systems are still not clear. The aim of this study was to determine the spinal functions of BNP-NPRA and GRP-GRPR systems for regulating scratching activities in mice by using pharmacological and immunohistochemical approaches. Our results showed that intrathecal administration of BNP (0.3–3 nmol) dose dependently elicited scratching responses, which could be blocked by the NPRA antagonist (Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-atrial natriuretic factor(6-18) amide (A71915). However, A71915 had no effect on intrathecal GRP-induced scratching. In contrast, pretreatment with a GRPR antagonist (D-Tpi6,Leu13ψ(CH2-NH)-Leu14)bombesin(6-14) (RC-3095) inhibited BNP-induced scratching. Immunostaining revealed that NPRA proteins colocalize with GRP, but not GRPR, in the superficial area of dorsal horn, whereas BNP proteins do not colocalize with either GRP or GRPR in the dorsal horn. Intradermal administration of ligands including endothelin-1, U-46619, bovine adrenal medulla 8-22, and Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SLIGRL) increased scratching bouts at different levels of magnitude. Pretreatment with intrathecal A71915 did not affect scratching responses elicited by all four pruritogens, whereas pretreatment with RC-3095 only inhibited SLIGRL-induced scratching. Interestingly, immunostaining showed that RC-3095, but not A71915, inhibited SLIGRL-elicited c-Fos activation in the spinal dorsal horn, which was in line with behavioral outcomes. These findings demonstrate that: 1) BNP-NPRA system may function upstream of the GRP-GRPR system to regulate itch in the mouse spinal cord, and 2) both NPRA and GRPR antagonists may have antipruritic efficacy against centrally, but not peripherally, elicited itch.
|
2022-12-12T01:44:33.445Z
|
216,361,934 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1680/jfoen.19.00019",
"MAG": "3012977063",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The train-induced vibrations that permeate railway environments are becoming more prominent with the rapid development of China’s high-speed railway network. Because canyons are quite common in nat...
|
2022-12-10T01:49:53.760Z
|
45,333,583 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1212/WNL.57.7.1350",
"MAG": "1987143968",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background: Samuel Adams (1722–1803), the American Revolutionist and brewer, is said to have had a tremor. There has not been a formal study of the clinical characteristics and progression of his tremor. Objective: To use historical accounts and original materials to document the clinical characteristics and progression of Adams’ tremor. Materials: In addition to historical accounts of Adams, the following materials were reviewed: 1) Samuel Adams’ known writings, including personal and political letters, published posthumously in a four-volume book; and 2) original letters and speeches (handwritten by Adams) that are held in collection in the Manuscripts and Archives Division of the New York Public Library. Results: Adams had a tremor that affected his hands, head, and voice. Although mild, the tremor was already manifest when Adams was in his early 40s. Adams, who was very prolific, experienced progressive difficulty with his ability to write while in his 50s and early 60s. His letters contain frequent references to his illness and reveal a penmanship that became more compromised with time. By age 71, he was forced to dictate all his correspondence. His tremor was familial, affecting his daughter Hannah and her children. Conclusions: Samuel Adams’ progressive tremor rendered him unable to write his own letters for the last 10 years of his life. Adams had one of the earliest documented cases of essential tremor.
|
2022-12-20T23:47:07.220Z
|
225,707,447 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15294/FIS.V47I1.23424",
"MAG": "3085248308",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Media social helps and supports society to do their activities associated with interaction among them, such as government activity to create transparency in informatics. This development shows that social media become inseparable resource with great impacts. One of the social medias that is being used by government is Twitter that gives features like uploading pictures, making link or hashtag. This study is focused on the strategy of the government of Central Java province uses Twitter as media social by cooperating with Twitter Indonesia. The government of Central Java launces Twitter Kemala ( Kelola Melantas Layanan ) as a tool to optimized social media to increase the quality of public services in order to accommodate the society’s interests. Through hashtag #KemalaJateng, the people of Central Java can send their ideas, complains, supports and questions which will be directly responded and reported by the related agencies in the government of Central Java. The purpose of this study is to understand the strategy of the government of Central Java optimizing social media, Twitter, to carry out the obligation as public bodies according UU No. 14, 2008 about public information transparency. In this study the descriptive qualitative method was used in which Communication and Informatics Agency of Central Java and Twitter of Central Java province account was the subject of this study. The result shows that the government of Central Java able to optimized the Twitter Kemala Jateng by responding actively and quickly as their strategy to create good governance according the law.
|
2022-01-27T01:45:29.771Z
|
239,669,971 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3329/ralf.v8i2.55491",
"MAG": "3197683666",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.banglajol.info/index.php/RALF/article/download/55491/38906"
}
|
The main purpose of the study was to determine the participation of Local Service Providers (LSPs) in systemic market approaches (SMA) in dairy sectors in two Upazilla Pirgacha and Badargonj under Rangpur district. Ninety-nine (99) LSPs were randomly selected as sample from an updated list of 495 LSPs. A pretested and structured interview schedule was used to collect data from the respondents during 16 August to 17 September 2018. Simple and direct questions with different appropriate scales were used to obtain information. Descriptive statistics, correlation, and multiple regression analysis were used. The top-ranked activities regarding the participation of LSPs was referral linkage with DLS for the critical or serious condition of livestock treatment, linkage with dairy producers’ group to assess the demand of information, develop collection point’s adjacent place of the community. Slightly above four-fifths (84.8 percent) of the respondent had high participation in systemic market approaches. Correlation analysis indicated that among seven selected characteristics of the respondent’s annual income, cosmopoliteness, training received, innovativeness, and extension media contact of the respondents had significant positive relationship with their participation in SMA, however, age and family size had no significant positive relationship. Regression analysis indicated that cosmopoliteness, training received, innovativeness, and extension media contact of the respondents had a positive contribution with their participation in SMA. The top-ranked problem (1st) faced by the LSPs was ‘legal permission from Government authority and apparently, the lowest proportion of LSP faced problems on ‘Lack of vehicle service for their movement’ service on dairy subsectors.
Res. Agric., Livest. Fish.8(2): 211-221, August 2021
|
2022-01-27T18:16:23.451Z
|
251,098,265 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0003055400240690",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A C K O F F , R U S S E L L L. WITH G U P T A , S. K. AND M I N A S , J . S. Scientific Method: Optimizing Applied Research Decisions. (New York : John Wiley & Sons, Inc. 1962. P p . xii, 464. $10.25.) AGPALO, R E M I G I O E . The Political Process and the Nationalization of the Retail Trade in the Philippines. (Diliman, Q. C.: N E C A I D , University of Philippines Development Project. 1962. P p . xv, 344. No price given.)
|
2022-07-30T23:55:12.800Z
|
120,489,223 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0026-1394/4/4/008",
"MAG": "2031500935",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The design and performance of platinum resistance thermometers are evaluated for periods of up to 5000 h exposure between 1050 °C and 1100 °C. These thermometers are designed as interpolation instruments for the International Practical Temperature Scale (IPTS). Long term stability and high temperature insulation resistance measurements were of particular interest, and after an initial 500 h of high temperature exposure, drift rates measured at 0 °C were as low as 0.002 °C per 100 h. Insulation resistance was inferred from measurements between the sensing element and a fifth lead wire adjacent to and insulated from the element. An electrical analog was used to establish the correlation between this measurement and the true shunting resistance due to electrical leakage at high temperatures. These measurements suggest that the sensing element resistance could be increased up to a factor of two or three without causing errors greater than 0.001 °C due to insulation effects, thereby reducing the sensitivity requirements on null detectors.
|
2022-09-08T22:30:38.537Z
|
44,044,074 |
{
"externalids": {
"ACL": null,
"ArXiv": "1009.3946",
"DOI": "10.1117/12.857713",
"MAG": "2577495773",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://authors.library.caltech.edu/71646/1/77321Y_1.pdf"
}
|
The hard X-ray sky now being studied by INTEGRAL and Swift and soon by NuSTAR is rich with energetic phenomena and highly variable non-thermal phenomena on a broad range of timescales. The High Energy Telescope (HET) on the proposed Energetic X-ray Imaging Survey Telescope (EXIST) mission will repeatedly survey the full sky for rare and luminous hard X-ray phenomena at unprecedented sensitivities. It will detect and localize (<20", at 5σ threshold) X-ray sources quickly for immediate followup identification by two other onboard telescopes - the Soft X-ray imager (SXI) and Optical/Infrared Telescope (IRT). The large array (4.5 m2) of imaging (0.6 mm pixel) CZT detectors in the HET, a coded-aperture telescope, will provide unprecedented high sensitivity (~0.06 mCrab Full Sky in a 2 year continuous scanning survey) in the 5 - 600 keV band. The large field of view (90° × 70°) and zenith scanning with alternating-orbital nodding motion planned for the first 2 years of the mission will enable nearly continuous monitoring of the full sky. A 3y followup pointed mission phase provides deep UV-Optical-IR-Soft X-ray and Hard X-ray imaging and spectroscopy for thousands of sources discovered in the Survey. We review the HET design concept and report the recent progress of the CZT detector development, which is underway through a series of balloon-borne wide-field hard X-ray telescope experiments, ProtoEXIST. We carried out a successful flight of the first generation of fine pixel large area CZT detectors (ProtoEXIST1) on Oct 9, 2009. We also summarize our future plan (ProtoEXIST2 & 3) for the technology development needed for the HET.
|
2022-10-28T00:43:45.168Z
|
239,784,857 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1161/circ.138.suppl_1.17328",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Introduction:
Adult Fontan patients are typically prescribed antiplatelet or anticoagulant therapy to manage increased risk for thrombotic and embolic complications (TECs). There is a Class III recommendation against the use of novel oral anticoagulants (NOACs) in this population due to a paucity of data. We hypothesized that NOACs are potentially non-inferior to warfarin in adult Fontan patients.
Methods:
We performed a multi-site retrospective review of adult Fontan patients, evaluated at three major academic medical centers (1995-2018), prescribed NOAC, warfarin, or aspirin therapy.
Results:
We identified 267 adult Fontan patients: 48 on NOACs, 107 on warfarin, and 180 on aspirin (14.4% to 54.2% cross-over amongst groups). Patients were more likely to have clinically significant bleeds (“bleeds”) if on a NOAC (HR=9.3, CI=3.0-28.4) or warfarin (HR=4.1, CI=1.6-10.5) versus aspirin. Bleed hazard ratio differences between NOAC and warfarin patients were not statistically significant (HR=2.3, CI=0.9-5.9). Patients on NOACs were not more likely to suffer TECs than patients on warfarin (HR=1.7, CI=0.4-6.3) or aspirin (HR=2.8, CI=0.7-10.3). Aspirin patients were younger, healthier, and had more favorable Fontan palliation. The traditional scoring systems to predict bleeds (HAS-BLED) and TECs (CHA
2
DS
2
VASc) were not predictive in this patient population. The only risk factor we identified for bleeds was a history of/predisposition to bleeding (OR=10.2, CI=4.4-23.6). Risk factors we identified for TECs included diabetes mellitus (OR=5.0, CI=2.2-11.4), labile international normalized ratio (OR=3.7, CI=1.1-12.4), and CHF (only in the NOAC/warfarin subgroup, OR=4.4, CI=1.2-16.3).
Conclusions:
NOACs are a potentially noninferior alternative to warfarin for adult Fontan patients. Our findings have laid the groundwork for a randomized control trial comparing the use of NOACs to warfarin in adult Fontan patients to test noninferiority or equivalence.
|
2022-12-14T20:10:27.273Z
|
118,919,111 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1070/QE2005V035N09ABEH003404",
"MAG": "335290438",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Various oscillation regimes of an actively mode-locked semiconductor laser are studied experimentally. Two types of regimes are found in which the minimal spectral width (~3.5 kHz) of intermode beats is achieved. The width of the optical spectrum of modes is studied as a function of their locking and the feedback coefficients. The maximum width of the spectrum is ~3.7 THz.
|
2022-12-15T07:00:41.831Z
|
84,883,707 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1139/B95-267",
"MAG": "2054949984",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
γ-Tubulin is present in phylogenetically diverse eukaryotes. It is a component of microtubule organizing centers such as the spindle pole bodies of fungi. In Aspergillus nidulans and Schizosaccharomyces pombe, it is essential for nuclear division, and, thus, for viability. In A. nidulans, nuclei carrying a γ-tubulin disruption can be maintained in heterokaryons, and the phenotypes caused by the disruption can be determined in uninucleate spores produced by the heterokaryons. Experiments with heterokaryons created in strains with mutations that allow synchronization of the cell cycle reveal that γ-tubulin is not required for the transition from the G1 phase of the cell cycle through S phase to G2, nor for the entry into mitosis as judged by chromosomal condensation. It is, however, required for the formation of the mitotic spindle and for the successful completion of mitosis. Staining with the MPM-2 monoclonal antibody reveals that spindle pole body replication occurs in the absence of functional γ-tubulin...
|
2022-12-18T05:29:15.818Z
|
110,915,514 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1115/1.3269219",
"MAG": "2057799735",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://vibrationacoustics.asmedigitalcollection.asme.org/data/journals/jvacek/28963/458_1.pdf"
}
|
Recently, a number of books on structural dynamics have been published. This book is unique among them since it presents information on stiffness, flexibility, and transport (transfer) matrices. The book, although brief, does present a number of interesting applications. It contains 195 solved problems. As stated by the authors, "This book . . . was prepared to serve as a college outline in the first standard course in structural dynamics. The book may be used in a formal course or as a supplement to all current texts on the subject. The numerous solved problems with conclusions underlying the major points of solutions constitute the best means of understanding the basic principles." Chapter 1 presents the basic ideas of dynamics employed in structural analysis. It includes Newton's law, virtual work and mention of Lagrange's and Hamilton's equations. Chapter 2 delves into single-degree-of-freedom systems. It considers mechanical and Hookean models, free and forced vibration (with and without damping), the Kelvin model and introduction to the transport (transfer) matrix. The Dirac delta function is employed in solution of an impulsive load. Chapter 3 continues with systems of several degrees of freedom. This includes free and forced vibration (with and without damping), properties of natural modes, and modal analysis. The section on transport matrix concludes the chapter. Chapter 4 focuses upon energy methods. These encompass the equations for generalized forces (spring, damping, and applied loads), and derivation of the Lagrange equation. The chapter concludes with small accelerations and oscillations in generalized coordinates utilizing potential, kinetic, and dissipation energies. A number of solved problems show the use of these concepts. The reviewer feels that a more detailed and application problem discussion of Hamilton's principle is in order. Chapter 5 delves into matrix methods. The authors show how the transport, flexibility, and stiffness matrices are derived. These are implemented in lumped mass systems accompanied by a number of excellent worked out examples. The relation between the transport (transfer) matrix and stiffness matrix should have been derived and explained. Chapter 6 continues with distributed mass systems. This embraces free and forced longitudinal vibration of a finite straight bar and free and forced transverse vibrations. This chapter contains excellent tables for a number of loading conditions on simple beams. The worked-out examples explaining forced vibration are excellent. Chapter 7 extends the information of the previous chapter by digging into distributed mass systems. This contains the solutions of differential equations of free and forced vibration introduced in Chapter 6 applied to secondary effects, i.e., on an elastic foundation and on beam columns. The Timoshenko beam is next examined and accompanied by solutions shown for various end conditions. The next chapter deals with the assembly of beam columns and longitudinal and transverse vibrations of beams in transport matrix form. The novel inclusion of the closed form of transport matrix coefficients expressed by MacLauren's and matrix coefficients is a definite plus. This is rarely seen in books on structural dynamics. Chapter 9 explains the concepts of dynamic flexibility and stiffness methods. The flexibility and stiffness coefficients are tabulated in nondimensional forms with worked-out examples. One of the novel features of this chapter is the solution of the three moment equations in closed form using the slope deflection in both the flexibility and stiffness matrices. The last chapter reports upon vibration of variable crosssection members. Beginning with the differential equations of varying section bars and beams, consideration is given to lumped and stepped mass and substitute function methods. All these are represented in matrix forms accompanied by well-explained examples. In summary, this is a good book. However, the reviewer believes that a number of topics and features should be added. A table with nomenclature should be included since the symbols in this text are not the same as those commonly used in other texts. Additional examples should be incorporated showing how finite elements are collected and used. Substructuring as applied to dynamics and a discussion of modal analysis might also be incorporated. Shock response might also be included. The reviewer further recommends that the authors consider writing an advanced text on structural dynamics. The reviewer feels that this book is a bargain considering its contents. The book is recommended to the neophyte as well as to experienced personnel interested in structural dynamics.
|
2022-12-19T01:42:34.388Z
|
12,379,132 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00140138708969695",
"MAG": "2073374772",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In industrialized countries there has been a steady trend towards the reduction of the amount of work which can be regarded as ‘heavy’ in the traditional meaning of the word. Many heavy work operations have been wholly or partly mechanized and replaced by jobs which place fresh demands on physical working capacity but require a greater use of other human attributes, such as eyesight, precision and stamina. Because much of today's work is repetitive, carried out in a sitting position and demanding good vision, ergonomics, as a science, has changed in recent years. Formerly, it aimed at eliminating heavy physical work. Now interest centres on optimizing individual work stations, both from the technical and organizational points of view. Poor adjustment between the technical system and the individual not only increases the work load for the person in question, it reduces effectivity at the same time: and effectiveness is productivity. At the Ericsson Group, which develops and manufactures products and system...
|
2022-01-27T20:14:18.879Z
|
161,293,941 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/4128393",
"MAG": "1980288635",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
tool traditions in South America. Of particular note are discussions in chapter 4 of fluted-point forms and technology and the emerging differences in bifacial and unifacial industries in the Paleoindian records of South and North America. Although brief, the latter discussions provide up-to-date summaries of two controversial issues in the peopling of South America debate. Arguably, the greatest appeal of this book to the professional community will be the detailed synopses of the South American Paleoindian period presented in chapters 5 and 6. Dillehay has done a yeoman's job of condensing a wealth of information, much of it drawn from Spanish-language books, journals, and manuscripts. However, the prose in these chapters is at times repetitive and regrettably stiff, and the overall presentation weighty. A judicious use of tables summarizing site information by region along with a larger complement of photographs illustrating key artifacts and assemblages, site details, and so forth, certainly would have enhanced this presentation. While this criticism can be extended to the book as a whole, nowhere is it more apparent than in these two pivotal chapters.
|
2022-02-08T22:19:42.730Z
|
103,682,861 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1360/CSB1986-31-14-1041",
"MAG": "2731662930",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
从1977以来,作者曾发展了一种方法,对于多种初等几何与微分几何,可以机械方式有效地证明并发明定理,参阅文献[1a—e】与[2].这一机械化方法并已进一步发展到可以应用于理论以及实际上提出的各种问题,而不必要求与几何学有关(参阅文献[1f]). 本文将是阐述
|
2022-02-10T09:15:57.987Z
|
53,508,362 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21275/art20175681",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.21275/art20175681"
}
|
: Search engines and social media websites offer us great services, but they collect their users' information, which could be considered as a privacy violation. It requires some serious work to increase user's privacy level while using search engines services or surfing social media websites, and especially for patients, whom records are considered confident, and these websites are capable to create a medical profile for each of them. Our contribution in this paper is to propose a new method that enables us to increase users' privacy level while using existing search engines and social media websites without replacing them, in a way that disables those websites from accessing users' information.
|
2022-03-25T20:16:24.535Z
|
95,653,758 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2133/DMPK.11.404",
"MAG": "1991351862",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The plasma protein binding of 14C-clonidine in vitro and in vivo and its transfer into the fetus and milk in rats were investigated. 1. The binding ratios of radioactivity in vitro to male rat, dog, monkey and human plasma proteins did not change with drug concentration in any species and no marked species difference was observed, however, in vivo binding to male rat, dog and monkey plasma proteins tended to increase with the elapse of time. 2. After subcutaneous administration to pregnant rats at a dose of 1 mg/kg, the radioactivity levels in the fetal kidney and liver were higher than that in the maternal plasma. The radioactivity was rapidly eliminated from the fetal tissues as that from the maternal plasma. On the whole body autoradiograms, comparable radioactivity was found in the fetus with the maternal plasma. 3. The radioactivity level in the milk reached a maximum at 30 min after subcutaneous administration at a dose of 1 mg/kg, being 5.5 times higher than that in the plasma, but was comparable with that in the plasma after 8 hr and decreased to undetectable level at 72 hr after administration.
|
2022-06-28T03:55:52.236Z
|
32,866,773 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1365-2265.1978.tb01498.x",
"MAG": "2032475055",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The clinical and endocrine features of fifty cases of male pseudohermaphroditism and XY karyotype aged from 6 months to 20 years have been studied. Thirty‐two subjects were pre‐pubertal and eighteen, of whom ten developed gynaecomastia, were pubertal. A definite aetiology was established in 12%. 4% had deficient testosterone biosynthesis and 8% mixed gonadal dysgenesis. In the remaining 88% an aetiology of androgen unresponsiveness at the target areas is suggested. Hormonal investigations in these subjects showed that before puberty basal plasma testosterone and oestradiol were slightly but significantly elevated, whereas testosterone response to stimulation with human chorionic gonadotrophin was significantly diminished. In the pubertal subjects basal plasma testosterone, oestradiol, serum binding capacity of testosterone‐oestradiol binding globulin and basal plasma LH were significantly elevated. These hormonal features in pubertal or post‐pubertal male pseudo‐hermaphrodites appear to be characteristic of androgen unresponsiveness. The presence in addition of elevated basal plasma testosterone and oestradiol in the pre‐pubertal subjects suggest that some of these findings may be present from early childhood.
|
2022-09-15T08:46:15.616Z
|
24,567,089 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1530/ACTA.0.0780032",
"MAG": "2046736515",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A method is described for measuring the rate at which thyroxine dissociates from binding proteins in human plasma. The method depends upon the fact that free thyroxine is able to diffuse through Visking dialysis membrane whereas bound thyroxine cannot. At 20 degrees C half of the plasma thyroxine dissociates within about 200 seconds and 75% within 10 min. At 37 degrees C half of the hormone dissociates in less than 20 seconds and the reaction is virtually complete in 3-4 min. These values agree well with those previously obtained by a resin-uptake method. In the Discussion it is calculated that the pool of free thyroxine in the plasma is replinished about 5 times 10-6 times each day and that an individual thyroxine molecule spends only about 15 mseconds in free solution during each transit.
|
2022-11-12T15:31:58.039Z
|
53,071,061 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3354/MEPS133143",
"MAG": "2023652188",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Marine fish farms use many antibacterial agents to prevent or fight bacterial diseases. The major part of the orally supplied drugs reach the environment, either directly due to excessive feeding and reduced appetite of the cultured fish, or indirectly after passing through the fish. Some of the drugs entering the environment may be taken up by bivalves. Comparative contamination and decontamination of Japanese oyster Crassostrea gigas and blue mussel Mytilus edulis were studied when these bivalves were kept during 10 d in seawater containing oxytetracycline (OTC) or oxolinic acid (OA) at concentrations of 0.15 and 1.50 mg l(-1). After the 10 d exposure at the seawater concentrations of 0.15 and 1.50 mg l(-1), OTC and OA concentrations in bivalve tissues were respectively 0.09 to 0.16 and 0.70 to 1.40 mg kg(-1). OTC, which is in a large part bound to ions and organic molecules in seawater, was less absorbed by bivalves than OA and therefore contaminated their tissues less than did OA. However, OTC, whose binding to mineral and organic compounds of the bivalve tissues is stronger than OA, was eliminated more slowly from the bivalve tissues than OA. Differences of contamination and decontamination of the bivalve species may be related to some chemical properties of the antibacterial agents and to some anatomical and physiological specificities of the bivalve. The biotransformations of the antibacterials agents by the bivalves did not seem to play a prominent part in the contamination and decontamination of the bivalve tissues.
|
2022-12-02T10:40:48.608Z
|
104,346,342 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/CATAL9010101",
"MAG": "2908880449",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Inspired by the active site structures of lactate racemase and recently reported sulphur–carbon–sulphur (SCS) nickel pincer complexes, a series of scorpion-like SCS nickel pincer complexes with an imidazole tail and asymmetric claws was proposed and examined computationally as potential catalysts for the asymmetric transfer hydrogenation of 1-acetonaphthone. Density functional theory calculations reveal a proton-coupled hydride transfer mechanism for the dehydrogenation of (R)-(+)-1-phenyl-ethanol and the hydrogenation of 1-acetonaphthone to produce (R)-(+)-1-(2-naphthyl)ethanol and (S)-(−)-1-(2-naphthyl)ethanol. Among all proposed Ni complexes, 1Ph is the most active one with a rather low free energy barrier of 24 kcal/mol and high enantioselectivity of near 99% enantiomeric excess (ee) for the hydrogenation of prochiral ketones to chiral alcohols.
|
2022-12-02T11:42:45.707Z
|
25,517,740 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3354/dao02066",
"MAG": "1982199565",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.int-res.com/articles/dao2009/85/d085p105.pdf"
}
|
Atlantic cod Gadus morhua L. juveniles weighing 40 g were challenged with infectious pancreatic necrosis virus (IPNV) by intraperitoneal (i.p.) or intramuscular (i.m.) injection or by bath. The amount of infectious virus was determined over 6 wk in head kidney, heart and pylorus tissues. No mortality or clinical signs were observed in either of the challenged groups. However, 6 wk after challenge virus was still present in the fish, which shows that IPNV can persist asymptomatically in cod. I.p. and i.m. injections were the most efficient routes of challenge giving the highest virus recovery. The prevalence of individuals with a viral titre > or = 500 infectious units g(-1) tissue was lower in the group of fish challenged by bath; thus bath was a less efficient route of challenge than injection. Our data also show that pylorus and head kidney are target organs for IPNV in cod, and levels of virus recovery were not considerably different between these 2 organs. Challenged by injection, the cod heart is also a target organ for IPNV. Compared to head kidney and pylorus, the heart seems to have a minor role in virus multiplication. Virus was also recovered from cohabiting fish, demonstrating that covertly infected cod may represent a reservoir of infectious IPNV for surrounding fish populations. Expression analysis of selected cod immune genes showed that i.p. injection of IPNV induced gene expression of ISG15 and LGP2, markers for the innate antiviral defence, while expression of markers for the inflammatory response (interleukins IL-1 beta, IL-8, IL-10) was not significantly increased.
|
2022-12-08T23:38:16.417Z
|
8,065,168 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1399-0039.2009.01235.x",
"MAG": "2128685775",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We have analysed the frequency of killer immunoglobulin-like receptors (KIR) in cohorts of patients from Turkey with acute lymphocyte leukaemia (n = 52), acute myeloid leukaemia (n = 54) and chronic myeloid leukaemia (CML) (n = 52) and compared the results with 154 controls. We also examined the frequencies of human leucocyte antigen (HLA)-C groups, -Bw4, -Bw6 and where appropriate the combination of the KIR gene and its ligand. We found several statistically significant results between the patients and the controls. We proposed a model in CML of protection via KIR2DL2 and/or KIR2DS2 with the presence of the ligand HLA-C1 group and susceptibility via HLA-Bw4 homozygosity (i.e. absence of HLA-Bw6).
|
2022-12-17T11:02:11.696Z
|
6,264,296 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ac502378e",
"MAG": "2327487419",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://hal.archives-ouvertes.fr/hal-01981311/file/islandora_72254.pdf"
}
|
Here we report the complete characterization of the primary structure of a multimeric glycoprotein in a single analysis by capillary electrophoresis (CE) coupled to mass spectrometry (MS). CE was coupled to electrospray ionization tandem MS by means of a sheathless interface. Transient isotachophoresis (t-ITP) was introduced in this work as an electrokinetically based preconcentration technique, allowing injection of up to 25% of the total capillary volume. Characterization was based on an adapted bottom-up proteomic strategy. Using trypsin as the sole proteolytic enzyme and data from a single injection per considered protein, 100% of the amino acid sequences of four different monoclonal antibodies could be achieved. Furthermore, illustrating the effectiveness and overall capabilities of the technique, the results were possible through identification of peptides without tryptic miscleavages or posttranslational modifications, demonstrating the potency of the technique. In addition to full sequence coverages, posttranslational modifications (PTMs) were simultaneously identified, further demonstrating the capacity of this strategy to structurally characterize glycosylations as well as faint modifications such as asparagine deamidation or aspartic acid isomerization. Together with the exquisite detection sensitivity observed, the contributions of both the CE separation mechanism and selectivity were essential to the result of the characterization with regard to that achieved with conventional MS strategies. The quality of the results indicates that recent improvements in interfacing CE-MS coupling, leading to a considerably improved sensitivity, allows characterization of the primary structure of proteins in a robust and faster manner. Taken together, these results open new research avenues for characterization of proteins through MS.
|
2022-12-30T01:24:06.544Z
|
22,135,625 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/jgh.12383",
"MAG": "2315229999",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A 59-year-old man was admitted to our hospital with dyspnea and pain in the right chest. He had been previously diagnosed with idiopathic chronic pancreatitis and had been followed for 3 years at another hospital. His alcohol intake was low and he did not have cholelithiasis, diabetes or hyperlipidemia. Blood tests revealed a mild elevation of his white cell count (9200/mm), a low albumin (2.6 g/dL, 26 g/L) and a mild elevation of amylase (421 U/L) and lipase (724 U/L). A C-reactive protein level was within the reference range. A chest radiograph revealed a large pleural effusion in the right thorax. An abdominal computed tomography (CT) scan showed an atrophic pancreas with a dilated main pancreatic duct and a pseudocyst in the head of the pancreas. Thoracentesis revealed blood-stained fluid with an amylase level of 10,700 U/L, a lipase of 72,500 U/L and a total protein of 2.8 g/dL. Endoscopic retrograde pancreatography (ERP) showed an irregular and dilated main pancreatic duct, a pseudocyst in the head of the pancreas and extravasation of contrast from the pseudocyst into the right pleural cavity (Figure 1). The appearance was typical of a pancreaticopleural fistula. A CT scan was repeated immediately after ERP and the scout film confirmed the presence of a pancreaticopleural fistula (Figure 2 left). A sagittal view showed contrast in a fistula around the inferior vena cava (anterior side) that appeared to extend through the foramen of the vena cava (Figure 2 right). He was treated with chest tube drainage, total parenteral nutrition and subcutaneous injections of octreotide acetate (200 g/day) for 8 weeks. The pleural effusion resolved and has not recurred. In chronic pancreatitis, pancreatic duct disruption may result from rupture of a pseudocyst or pancreatic inflammation associated with at least partial duct obstruction. The most common outcome is pancreatic ascites but, in some patients, pancreatic secretions can track into the mediastinum and rupture into the pleural space. The fistulous track normally passes through the aortic or esophageal hiatus but, in the above case, appeared to pass through the foramen of the vena cava. The diagnosis is usually made by the finding of a high amylase and lipase concentration in the pleural fluid. The origin and pathway of the fistula can sometimes be demonstrated by magnetic resonance cholangiopancreatography but many patients are investigated using ERP. The initial management usually involves parenteral nutrition and octreotide but closure of the fistula only occurs in approximately 50% of patients. The remainder have various surgical procedures including distal pancreatectomy and operative drainage of pancreatic cysts.
|
2022-03-05T23:51:28.458Z
|
170,568,570 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4000/cultura.2248",
"MAG": "2300539605",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.openedition.org/cultura/pdf/2248"
}
|
Jose de Sousa Pereira, membro do Conselho da Fazenda de D. Pedro II, foi enviado a Roma com a embaixada do Bispo de Lamego entre 1676 a 1682. Consignou as impressoes da viagem A politica dos princepes de Italia em 1680, decerto com a finalidade de fornecer modelos criticos aos governantes portugueses. Da apreciacao da politica italiana ressaltam simpatias pela republica veneziana, pelo Ducado de Saboia, mas tambem um conhecimento deficiente das politicas de Genova, Modena, Mântua, Parma e Lucca, tao reduzida e a informacao que sobre elas aduz. Fez ressaltar o peso da falta de unidade territorial da Italia, os inconvenientes do regime electivo e as vantagens do absolutismo, este atraves do modelo da corte papal e na participacao da nobreza, ao nivel dos outros Estados. Mas a sugestao utopica vai para a republica, atraves duma idealizacao do regime veneziano. Diplomata como era, Pereira nao enjeitou tambem interessantes observacoes sobre politica internacional.
|
2022-06-13T20:23:44.584Z
|
73,301,552 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7775/rac.80.2.1068",
"MAG": "2146697461",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A medical specialty may be defined as the body of knowledge corresponding to a specific medical field. This knowledge is provided by postgraduate training programs after completing the medical doctor degree. The goal of the present study is to review the different options available in our country to become a specialist in cardiology and, thus, determine if these diverse pathways produce equally trained cardiologists. Training should be understood as a long-term process that shapes professional thinking and social behavior. This process must be permanent and should have core regulations to ensure equal and homogenous training in the specialty. There are many ways of becoming a specialist in cardiology; most of these pathways may be combined and all of them use different tools for selecting, training, supervising, evaluating and controlling trainees. Thus, these differences in training and evaluating specialists might produce professionals with different levels of competencies.
|
2022-02-11T09:11:06.370Z
|
20,590,431 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/C6DT03843C",
"MAG": "2549112701",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Four isostructural 3D lanthanide(iii) metal-organic frameworks with the general formula (H6edte)0.5[LnIII(ox)2(H2O)] (Ln = Gd (1), Tb (2), Dy (3) and Ho (4); H4edte = N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine) and ox = oxalate have been synthesized from oxalate. These compounds were characterized using single-crystal X-ray diffraction, FTIR and TGA/DTG. The magnetic investigation has been performed for 1-4 and the results reveal that a Gd(iii) containing MOF has the highest magnetic density and exhibits a larger cryogenic magnetocaloric effect (ΔSm = 35.9 J kg-1 K-1 for ΔH = 9 T at 2.0 K) with a high Debye temperature (θD = 342(3) and rD = 35). For the Dy derivative, an ac-out-of-phase signal was found, and further measurements under an applied field of 1000 Oe showed frequency-dependent out-of-phase magnetic susceptibility. Solid-state luminescence indicates that Tb and Dy-containing complexes are photoluminescent materials.
|
2022-12-19T08:20:22.604Z
|
146,249,369 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0309132506070168",
"MAG": "2164410122",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The idea of progress disconcerts. While it is enshrined as an object in our research audit culture, its very existence is queried in many groves of the modern academy. Here I contend that the idea of ‘progress in geography’ has meant different things, at different times, in different places, and that it has been put to different cultural and political uses. The realization that ‘progress in geography’has its own geography might lead us in the direction of destabilizing the notion to the point of undermining it altogether. I believe that to be mistaken. Instead I argue for the retrieval of a chastened form of the idea of progress as a regulative ideal both epistemologically and morally.
|
2022-12-24T18:28:46.660Z
|
112,642,261 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/WWW.SCIENTIFIC.NET/MSF.853.64",
"MAG": "2342037977",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The economic crisis that began in Spain at the end of 2007 and early 2008, which still lasts today, has greatly harmed industry in the country. Many companies dissolved, and many workers who worked for them remained unemployed. But what effect did the financial crisis have on universities Apart from financial problems, they generally have had an increase in the number of students enrolled. Many of them are people who, after becoming unemployed, have decided to take time to improve their academic standing, and thus have more chances of finding a job when they finish. This paper will show how these people, with their knowledge and experience acquired in industry as workers, can add value to the manufacturing processes class.
|
2022-02-10T03:07:14.017Z
|
111,179,116 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1115/IPC2006-10429",
"MAG": "2048804148",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The current work contributes to the research in the area of pipelines non-destructive testing by presenting new methodologies for the automatic analysis of welds radiographs. Object recognition techniques based on genetic algorithms were used for the automatic weld bead detection. In addiction, we developed an image digital filter for the detection of defects in the weld bead zone. These methodologies were tested for 120 digital radiographs from carbon steel pipeline welded joints. These images were acquired by a storage phosphor system using double-wall radiographic exposing technique with single-wall radiographic viewing, according to the ASME V code. As a result, even defects that are hard to be detected by human vision are automatically highlighted and extracted from the whole image to be classified in the further stages of the weld inspection process.Copyright © 2006 by ASME
|
2022-02-10T04:30:24.737Z
|
149,767,769 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5027/JMH-VOL15-ISSUE2(2014)ART76",
"MAG": "2800923000",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
espanolEn el contexto de la Practica Pedagogica universitaria, a partir de una convocatoria abierta dirigida a los grupos decimo y once de la Institucion Educativa Antonio Ricaurte, ubicado en Belen Rincon/Comuna 16 de Medellin (Una de las mas grandes y pobladas de esta ciudad con 193.343 habitantes), se desarrolla una propuesta de intervencion pedagogica de tipo IAP; dos practicantes universitarios de licenciatura en educacion fisica y quince jovenes de ambos sexos asumen el rol de coinvestigadores, exploran, valoran y experimentan practicas ludocorporales escolarizadas y no escolarizadas que tengan a juicio de los participantes potencial educativo para la formacion de una ciudadania critica. EnglishIn the context of university pedagogical practice, from an open call directed to the tenth and eleventh degree students of the high school from the Educative Institution (E.I) Antonio Ricaurte in Belen Rincon/Commune 16 of Medellin (One of the largest and most populous of the city with 193,343 inhabitants), is developed a proposal of pedagogical intervention of IAP type; two college interns of physical education and fifteen young men and women assume the role of co-investigators which explore, appreciate and experience ludic-corporal practices both inside school and also outside school which have educative potential for the formation of a critical citizenship.
|
2022-03-08T10:17:08.295Z
|
27,026,995 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/HEALTH.2005.1500366",
"MAG": "1869492620",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article has been prepared on the basis of Resolution 41 on eHealth by WTDC 02, and taking into account some relevant contributions received by the ITU-D Study Group 2, Question 14-1/2 from Member states and the ITU-D Sector members including the World Health Organization. It is believed that this document will assist the telecommunication authorities from developing countries to establish the mutual beneficial cooperation with health care authorities in their respected countries and offer to them the full potential of modern information and communication technologies (ICT) to improve access to and even quality of health care. It is also hope that the document will be considered as the contribution from the ITU-D Study Group 2 to the World Health Organization (WHO) in the development of its strategies to guide the international utilization of ICT in the global health care environment for the benefit of all.
|
2022-09-03T10:04:58.830Z
|
59,478,608 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5897/JENE2015.0490",
"MAG": "2565197225",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Major challenges to the landscape level conservation intervention are to monitor and evaluate the conservation impacts in an accurate and cost-effective manner. Threat reduction assessment (TRA) has been proposed as a method to measure conservation success and as a proxy measurement of conservation impacts and monitoring threats. We conducted TRAs to evaluate the effectiveness of Nepal’s Terai Arc Landscape (TAL) program in mitigating threats to forests of seven corridor and bottleneck sites. We modified Margoluis and Salafsky (2001) framework and scoring approach and calculated TRA index. Threats were standardized to allow comparisons across the sites and effectiveness of management modes in reducing threats between the community-based management (CBM) and conventional government managed system (GMS). TRA index of CBM was significantly higher from those of GMS as evident by various parametric and non-parametric tests including principal component analysis. However, the TRA approach is not immune to bias as it depends on subjective analysis, but it could be a simple and cost-effective conservation monitoring tool to be easily implemented by local communities and stakeholders.
|
2022-09-12T07:09:29.008Z
|
201,740,123 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/j.ctvc7790m.14",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
What is marriage? The U.S. Supreme Court’s recent decisions on same-sex marriage beg the question for courtroom and public square alike. For Robert P. George—the intellectual leader of the fight against same-sex marriage—"marriage" only makes sense when it is "conjugal": the comprehensive, bodily union of a man and a woman. I disagree. But I do so not on the hitherto standard "constructivist" basis that marriage is "just what we say it is" but in morally realistic terms George might recognize. I argue that multiple ends and norms—consent, property, friendship, and goods beyond the couple—better explain the institution than does George’s unitary conjugal view.
|
2022-10-02T14:59:16.479Z
|
62,963,620 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/met.1574",
"MAG": "2506523301",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Considerable savings in winter road maintenance and accident costs can be achieved with accurate road weather forecasts. Forecasting road surface freezing time accurately enables the timely start of salting and thus ensures safety on roads. The optimal use of road weather observations is essential for the accuracy of short‐range road condition forecasts. Road weather models incorporate radiation and other atmospheric variables from numerical weather prediction models. In this study, observations were used to correct the forecast radiation and thus improve road weather forecasts for a set of specific sites. Eighteen different configurations of this methodology were tested for 20 road weather stations in Finland during the autumn–winter period 3 October 2013 to 13 January 2014. This study shows that the coupling method has potential to significantly improve road surface temperature forecasts. Two model configurations in particular turned out to be better than the others giving almost equally good road surface temperature forecasts. It was found that the length of the adjustment period using the corrected radiation had only a slight effect on the results. The outcome of this study can be used to improve road weather models and thus achieve more accurate forecasts.
|
2022-12-02T11:48:21.881Z
|
3,955,282 |
{
"externalids": {
"ACL": null,
"ArXiv": "1601.04084",
"DOI": "10.5441/002/edbt.2018.65",
"MAG": "2950449275",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Arguably data is a new natural resource in the enterprise world with an unprecedented degree of proliferation. But to derive real-time actionable insights from the data, it is important to bridge the gap between managing the data that is being updated at a high velocity (i.e., OLTP) and analyzing a large volume of data (i.e., OLAP). However, there has been a divide where specialized solutions were often deployed to support either OLTP or OLAP workloads but not both; thus, limiting the analysis to stale and possibly irrelevant data. In this paper, we present Lineage-based Data Store (L-Store) that combines the real-time processing of transactional and analytical workloads within a single unified engine by introducing a novel lineage-based storage architecture. We develop a contention-free and lazy staging of columnar data from a write-optimized form (suitable for OLTP) into a read-optimized form (suitable for OLAP) in a transactionally consistent approach that also supports querying and retaining the current and historic data. Our working prototype of L-Store demonstrates its superiority compared to state-of-the-art approaches under a comprehensive experimental evaluation.
|
2022-12-10T04:23:02.414Z
|
85,801,718 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0021859600010844",
"MAG": "2170327397",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The nutrition of the carrot in a light gravel soil of known analysis with high available phosphate has been studied by statistical pot-culture methods, and the responses, linear and curvature components, etc., due to nitrogen, phosphate, and potash, have been calculated. No hard and fast rule can be made as to the adequacy or otherwise of any particular fertilizer in a soil, as the different parts of the plant (top and root) were shown to be capable of responding quite differently to that fertilizer.
|
2022-09-14T04:16:17.208Z
|
204,134,094 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/c9ay01795j",
"MAG": "2976338797",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A highly sensitive mAb against TCD was produced by using a novel hapten, and basing on this mAb, a lateral flow immunoassay was developed for the rapid screening of TCD and its metabolites in foodstuff.
|
2022-10-05T15:39:45.276Z
|
231,643,567 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/jamanetworkopen.2020.32550",
"MAG": null,
"PubMedCentral": "7816107"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2775234/brodt_2021_oi_201004_1610136959.77297.pdf"
}
|
Key Points Question Are changes in collection of race/ethnicity data in American Medical College Application System surveys in 2002 associated with temporal trends in applicants, matriculants, and graduates who self-reported as American Indian/Alaska Native (AIAN)? Findings This cohort study found that, after the change in data collection, the mean number of AIAN applicants increased by 78%; matriculants, 62%; and graduates, 94%. The numbers of AIAN applicants continued to increase at 10% per year following the change, but no significant change in trend was found for matriculants or graduates. Meaning These findings suggest that changing the method of race/ethnicity data collection captures more AIAN applicants, matriculants, and graduates, but yearly trends indicate few differences after the change in terms of AIAN graduates.
|
2022-11-16T22:14:44.941Z
|
34,510,730 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1287/opre.22.1.197",
"MAG": "2058659259",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This note derives equations from which the maximum-likelihood estimates of the parameters of a circular normal distribution truncated outside a circular region may be obtained. The information matrix is included from which the asymptotic variances and covariances of the estimators may be obtained. A numerical example is given to illustrate the theory.
|
2022-11-18T00:17:25.700Z
|
144,750,242 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/713666081",
"MAG": "2067102655",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study examines teachers' understandings of dyslexia and its assessment by educational psychologists. Participants are 36 teachers in two focus groups. The results are discussed in the light of the Division of Educational and Child Psychology report on 'Dyslexia, Literacy and Psychological Assessment'. Proposals are considered for effective educational psychology practice and for further research useful to practice in this area.
|
2022-12-16T13:46:04.626Z
|
33,038,902 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1196/annals.1320.004",
"MAG": "2094332559",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract: Mitochondrial oxidation of long‐chain fatty acids provides an important source of energy for the heart as well as for skeletal muscle during prolonged aerobic work and for hepatic ketogenesis during long‐term fasting. The carnitine shuttle is responsible for transferring long‐chain fatty acids across the barrier of the inner mitochondrial membrane to gain access to the enzymes of β‐oxidation. The shuttle consists of three enzymes (carnitine palmitoyltransferase 1, carnitine acylcarnitine translocase, carnitine palmitoyl‐transferase 2) and a small, soluble molecule, carnitine, to transport fatty acids as their long‐chain fatty acylcarnitine esters. Carnitine is provided in the diet (animal protein) and also synthesized at low rates from trimethyl‐lysine residues generated during protein catabolism. Carnitine turnover rates (300‐500 μmol/day) are <1% of body stores; 98% of carnitine stores are intracellular (total carnitine levels are 40‐50 μM in plasma vs. 2‐3 mM in tissue). Carnitine is removed by urinary excretion after reabsorption of 98% of the filtered load; the renal carnitine threshold determines plasma concentrations and total body carnitine stores. Because of its key role in fatty acid oxidation, there has long been interest in the possibility that carnitine might be of benefit in genetic or acquired disorders of energy production to improve fatty acid oxidation, to remove accumulated toxic fatty acyl‐CoA metabolites, or to restore the balance between free and acyl‐CoA. Two disorders have been described in children where the supply of carnitine becomes limiting for fatty acid oxidation: (1) A recessive defect of the muscle/kidney sodium‐dependent, plasma membrane carnitine symporter, which presents in infancy with cardiomyopathy or hypoketotic hypoglycemia; treatment with oral carnitine is required for survival. (2) Chronic administration of pivalate‐conjugated antibiotics in which excretion of pivaloyl‐carnitine can lead to carnitine depletion; tissue levels may become low enough to limit fatty acid oxidation, although no cases of illness due to carnitine deficiency have been described. There is speculation that carnitine supplements might be beneficial in other settings (such as genetic acyl‐CoA oxidation defects—“secondary carnitine deficiency”, chronic ischemia, hyperalimentation, nutritional carnitine deficiency), but efficacy has not been documented. The formation of abnormal acylcarnitines has been helpful in expanded newborn screening programs using tandem mass‐spectrometry of blood spot acylcarnitine profiles to detect genetic fatty acid oxidation defects in neonates. Carnitine‐deficient diets (vegetarian) do not have much effect on carnitine pools in adults. A modest 50% reduction in carnitine levels is associated with hyperalimentation in newborn infants, but is of doubtful significance. The above considerations indicate that carnitine does not become rate‐limiting unless extremely low; testing the benefits of nutritional supplements may require invasive endurance studies of fasting ketogenesis or muscle and cardiovascular work.
|
2023-01-01T17:53:07.822Z
|
235,427,486 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/0015587x.2021.1923965",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
‘Lucky Joe’ in the volume. In ‘Trade’, Wilson offers a history of a small community located on a Native American site, where furs were traded. We learn that a single deerskin was called a ‘buck’, hence the nickname for the dollar. Joe Wilson’s legacy endures through his shaping of the annual National Folk Festival, the enhanced profile of folklore amongst American institutions such as the National Endowment for the Arts and the National Parks Service, and the establishment of ‘The Crooked Road’, which connects musical communities in South-West Virginia.
|
2022-07-09T01:44:18.721Z
|
53,345,510 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1585/PFR.12.1204024",
"MAG": "2648719124",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Department of Nuclear System Safety Engineering, Nagaoka University of Technology, Niigata 940-2188, Japan 1)Department of Energy and Environment Science, Nagaoka University of Technology, Niigata 940-2188, Japan 2)Department of Electrical Engineering, Nagaoka University of Technology, Niigata 940-2188, Japan 3)National Institute of Technology, Kagoshima College, Kagoshima 899-5193, Japan 4)Extreme Energy-Density Research Institute, Nagaoka University of Technology, Niigata 940-2188, Japan 5)Pulsed Power Japan Laboratory Ltd., Shiga 525-0058, Japan
|
2022-02-11T21:40:55.751Z
|
36,636,868 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1468-1331.2011.03427.x",
"MAG": "1651579953",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Sir, Dentatorubropallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disorder, characterized by ataxia, involuntary movement, and epilepsy. The clinical expression of DRPLA is primarily determined by an unstable expansion of exonic CAG repeats in the gene encoding atrophin-1, located on the short arm of chromosome 12 [1]. We report a pair of monozygotic twins with DRPLA who share identical CAG repeat lengths, present different clinical courses.
|
2022-08-17T07:31:12.482Z
|
30,174,545 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1107/S2056989015020575",
"MAG": "2411087330",
"PubMedCentral": "4719913"
},
"license": null,
"status": null,
"url": null
}
|
In the title compound, C14H13NO2, the mean plane of the non-H atoms of the central amide fragment C—N—C(=O)—C (r.m.s. deviation = 0.029 Å) forms dihedral angles of 5.63 (6) and 10.20 (5)° with the phenyl and hydroxyphenyl rings, respectively. A short intramolecular N—H⋯O contact is present. In the crystal, the molecules are linked by O—H⋯O hydrogen bonds to generate C(7) chains along [100]. The chains are reinforced by weak C—H⋯O contacts, which together with the O—H⋯O bonds lead to R 2 2(7) loops. Very weak N—H⋯O interactions link the molecules into inversion dimers.
|
2022-09-09T05:01:58.069Z
|
193,369,009 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4018/978-1-4666-8659-5.CH015",
"MAG": "2506297409",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
© 2016, IGI Global. All rights reserved. In this chapter we discuss the development of edutainment systems supported by augmented reality applications, in order to enable augmented reality technologies for archaeology within the so-called communication engine for museums and cultural tourism. The task in hand is interdisciplinary and its successful implementation relies heavily on information technology as a detailed analysis of contentuser needs and sound interaction design capable to support edutainment scenario is needed. This work identifies the role of each building component, describes their interrelationship within the wider context and adopts a suitably designed framework in order to develop multiple guided-tour types. Real-life case study scenario on a specific case, that of the Old Fortress in the UNESCO-listed Old Town of Corfu, Greece, are used to demonstrate the adaptive nature of content and how the system and developers handle different uses. The proposed approach offers new narration tools for content experts while it may be used to support personalised visitor experiences.
|
2022-11-07T22:26:33.791Z
|
98,236,322 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/APP.33326",
"MAG": "2057236015",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Response surface methodology was used to analyze the effects of the enzyme level (X2) and glycerol level (X1) on objective attributes [water solubility index (WSI), water absorption index (WAI), and maximum loading (Y3)] of a cornstarch/poly(β-hydroxybutyrate-co-valerate) blended composite. A rotatable central composite design was used to develop models for the objective responses. The experiments were run at barrel temperatures of 160, 160, 165, and 165°C, with a screw speed of 40 rpm and complete feeding (filling ratio = 1). Responses were most affected by changes in X2 and to a lesser extent by X1. Individual contour plots of the different responses were overlaid, and regions meeting the optimal WSI of 8.73%, WAI of 3.94 g of gel/g of dry weight, and Y3 of 304.17 N were established at an X2 of 5.43 g and an X1 of 120.79 mL. These predicted values for the optimal process conditions were in good agreement with the experimental data. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
|
2022-12-03T16:57:38.579Z
|
55,822,760 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5772/62035",
"MAG": "2257784287",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.5772/62035"
}
|
Mobile robots are useful for environment exploration and rescue operations. In such applications, it is crucial to accurately analyse and represent an environment, providing appropriate inputs for motion planning in order to support robot navigation and operations. 2D mapping methods are simple but cannot handle multilevel or multistory environments. To address this problem, 3D mapping methods generate structural 3D representations of the robot operating environment and its objects by 3D mesh reconstruction. However, they face the challenge of efficiently transmitting those 3D representations to system modules for 3D mapping, motion planning, and robot operation visualization. This paper proposes a quality-driven mesh compression and transmission method to address this. Our method is efficient, as it compresses a mesh by quantizing its transformed vertices without the need to spend time constructing an a-priori structure over the mesh. A visual distortion function is developed to govern the level of quantization, allowing mesh transmission to be controlled under different network conditions or time constraints. Our experiments demonstrate how the visual quality of a mesh can be manipulated by the visual distortion function.
|
2022-12-12T03:24:35.548Z
|
38,442,374 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ijc.23536",
"MAG": "1999717690",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.23536"
}
|
Vitamin D receptor (VDR) activation inhibits proliferation and angiogenesis in the colorectal epithelium, and inhibits metastasis of colorectal tumors. Polymorphisms in the VDR gene alter receptor cellular levels and functioning, and may confer altered susceptibility to colorectal neoplasia. We aimed to investigate the influence of VDR polymorphisms and dietary factors impacting on vitamin D metabolism on colorectal adenoma (CRA) recurrence. Data on dietary intakes of calcium, vitamin D and dairy products were collected from 853 participants in the United Kingdom Colorectal Adenoma Prevention trial, a randomized trial of aspirin and folate for CRA recurrence prevention. The VDR Cdx2, FokI, BsmI, ApaI and TaqI polymorphisms were genotyped in 546 participants with available DNA, and gene–diet interaction analyses performed in 480. Dairy product intake was inversely related to CRA recurrence risk independent of calcium and vitamin D [relative risk (RR) = 0.64; 95% confidence intervals (CIs): 0.47–0.88, for subjects in the highest compared to lowest intake tertile, ptrend = 0.005]. Milk accounted for 60% of dairy product intake, and on analysis of milk and nonmilk dairy products separately recurrence risk in individuals in the highest tertile of milk intake was half that of lowest tertile individuals (RR = 0.52; 95% CI: 0.38–0.72, ptrend = 3.2 × 10−5), whereas nonmilk dairy products did not influence recurrence. VDR polymorphism genotypes and haplotypes did not directly alter recurrence risk, but the reduction in risk associated with high dairy product intake was confined to individuals with ApaI aA/AA genotype (pinteraction = 0.02). These findings indicate dairy products, and in particular milk, have chemopreventive activity against CRA recurrence. © 2008 Wiley‐Liss, Inc.
|
2022-12-17T10:24:44.386Z
|
122,435,726 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CDC.1993.325200",
"MAG": "2117941037",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Steady state operation of engineering systems is generally around a stable equilibrium point. The concept of an equilibrium point for a dynamic system is well-established as a constant solution in the time domain. In other words, the system is at steady state at an equilibrium point when all time derivatives are equal to zero. In numerous text books, the standard mathematical definition of an equilibrium point x* for the dynamical system x/spl dot/=f(x) is that it satisfies the equation f(x*)=0. But it has been shown that this definition may be inadequate from an engineering point-of-view. The aim of the paper is to formally propose a rigorous definition for solutions and equilibrium points, which is also intuitively appealing. Here the concept of an equilibrium point is developed mathematically as a constant solution for the dynamic system, by first precisely defining the notion of an order of a solution. The basic motivation for the proposed definition of an order of a solution comes from the "continuity" concept of solutions in the state space. Order 1 equilibria correspond to the traditional definition of equilibrium points. But such points need not be equilibria in the real system. It is shown that the origin for the classical example x/spl dot/=x2/3 is physically not an equilibrium point, but behaves like a regular point. Other phenomena such as the presence of impasse points and unbounded higher order time derivatives can also be associated with conventional equilibrium points which hence are weak in scope. Several examples are presented in the paper to show the versatility of the new definition. The implications of the definition for special cases such as when the function f is smooth are established and are shown to be consistent with the existing notions. It is hoped that the proposed definitions will allow a rigorous extension of the results for equilibria of smooth systems to non smooth systems, but no such attempt is made in this paper.<<ETX>>
|
2022-12-13T17:58:09.808Z
|
92,451,146 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/MACP.1969.021240103",
"MAG": "156483235",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Verbindungen der allgemeinen Formel
initiieren in Gegenwart von Kupfer(Il)- und Halogenid-Ionen sowie von Sauerstoff die Polymerisation von ungesattigten Monomeren. Am Beispiel der Polymerisation des Methacrylsauremethylesters wird die Abhangigkeit der Polymerisationsgeschwindigkeit von der Substitution des Initiators in R′ bestatigt und gezeigt, das sie der HAMMETT-Beziehung gehorcht.
Compounds of the general formula
initiate polymerisation reaction of unsaturated monomers in the presence of Cu++, Cl−, and oxygen. The rate of polymerisation depends on the nature of R′ and is related to the HAMMETTT-equation as could be shown in the case of methylmethacrylate.
|
2022-02-10T18:07:48.713Z
|
38,156,363 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CLEOPR.2015.7376558",
"MAG": "2245725596",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
By directly measuring electric fields, we obtain equi-frequency contours of surface waves. In the metallic square lattice, the presence of the anisotropy from the equi-frequency contours is experimentally confirmed.
|
2022-02-12T06:40:36.631Z
|
18,185,443 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.6028/jres.107.033",
"MAG": "2463934401",
"PubMedCentral": "4861379"
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.6028/jres.107.033"
}
|
The indentation process of pressing a Rockwell diamond indenter into inelastic material has been studied to provide a means for the analysis, simulation and prediction of Rockwell hardness tests. The geometrical characteristics of the spheroconical-shaped Rockwell indenter are discussed and fit to a general function in a self-similar way. The complicated moving boundary problem in Rockwell hardness tests is simplified to an intermediate stationary one for a flat die indenter using principle of similarity and cumulative superposition approach. This method is applied to both strain hardening and strain rate dependent materials. The effects of different material properties and indenter geometries on the indentation depth are discussed.
|
2022-09-01T03:02:25.995Z
|
101,602,194 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/EF400470V",
"MAG": "2325863131",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We have investigated and established a preparative method of using a solid-phase extraction cartridge containing Ag+-exchange resin (Ag+-SPE) for separating olefins and paraffins in the saturate fractions of coal tar and petroleum coker oil. The successful separation of paraffins and olefins was confirmed by gas chromatography coupled with mass spectrometry (GC–MS). Proton nuclear magnetic resonance (1H NMR) spectroscopy was applied to determine the olefin structures for olefin-type distributions. None or negligible amounts of iso-α-olefins were detected by 1H NMR in the coal tar but were found significant in the coker oil. Gas chromatography coupled field ionization time-of-flight mass spectrometry (GC–FI-TOF MS) was employed to determine the molecular distribution of paraffins and olefins. With separate paraffin and olefin fractions, the differentiation between isomers, such as monocycloparaffins versus monoolefins, can be made.
|
2022-09-10T11:20:32.001Z
|
62,299,700 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICCD.1989.63344",
"MAG": "2158729098",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A highly concurrent second-generation RISC (reduced-instruction-set computer) that combines a powerful RISC architecture with sophisticated hardware design techniques to achieve a short cycle time and a low cycles-per-instruction (CPI) ratio is described. Like earlier RISC processors, this design uses a register-oriented instruction set, the CPU is hardwired rather than microcoded, and it features a pipelined implementation. Unlike earlier RISC processors, however, several advanced architectural and implementation features are used, including separate instruction and data caches, zero-cycle branches, multiple-instruction dispatch, and simultaneous execution of fixed- and floating-point instructions. The CPU has a four-word data bus to main memory, a four-word instruction-fetch bus from the I-cache arrays, and a two-word data bus between the D-cache and floating-point unit. The CPU has a full 64-b floating-point engine, and thirty-two 64-b floating point registers in addition to thirty-two 32-b fixed-point registers. In a single cycle, four instructions can be executed simultaneously.<<ETX>>
|
2022-09-10T14:01:22.659Z
|
64,815,381 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24884/1607-4181-2017-24-4-75-81",
"MAG": "2799463444",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.24884/1607-4181-2017-24-4-75-81"
}
|
Introduction. Mobile phones are worldwide spread nowadays. Smartphones penetration is growing year after year. Numerous studies indicate the negative effect of EMF exposure of these devices on humans. Therefore, it is important to study the peculiarities of their influence on the target organ-the brain. It is important for solving this problem to find out the real situation of the distribution of energy flux density (EFD) of EMF exposure near the front panel of the apparatus. The aim of the study is to determine and compare EMF exposure from smartphones and classic mobile phones on human head. Material and methods. The original method patented in the Russian Federation was used in this study. The used original measuring setup is also patented, developed and assembled by the authors of the study. The object of the study was classical mobile phones and smartphones widespread at the time of work. Results. We got the graphic of matrices of distribution of energy flux density (EFD) of EMF exposure in the plane against the front panel of 10 apparatus corresponding to the topography of a human head. The study revealed peculiarities of this distribution in smartphones and the classic mobile phones and got the values of energy flux density (EFD) of EMF exposure in the investigated devices acting primarily on the brain. Conclusions. The design of smartphones and mobile phones determines the overall picture of distribution of EFD of EMF exposure in the plane against the front panel for devices of a particular type. This picture must be taken into account when planning epidemiological and experimental studies to obtain comparable results. Progress in the development of mobile communication technologies has led to an increase in the electromagnetic load on users of modern devices.
|
2022-09-17T16:10:50.047Z
|
244,539,649 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/12269328.2021.2008274",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Heavy metal removal is a significant problem in various industries. Liquid-liquid extraction is a practical process in recovering these elements. In this study, the behavior of pilot-scale disc-donut column in the extraction of cadmium ions was evaluated. The effects of droplets with the variation size distributions are significant in describing performance and characteristics of an extractor for removing the substrate from aqueous or organic phases. The size distribution of droplets is relative to the interfacial area under steady conditions. To match the size distribution of droplets, the experiments are carried out in reaction and non-reaction conditions. In emulsion regime (pulsing intensity (Af), inlet organic and aqueous phase flow rate (Vc, Vd) equal to 3.3 cm/s, 2.22 mm/s, and 2.22 mm/s, respectively) and under the optimized conditions, 99.7% of the cadmium can be recovered from the aqueous solution. It was found that Weibull distribution gives the best fit at each operation mode while inverse Gaussian distribution gives the most inferior fit. According to a series of statistical analyses, it is shown that the pulsation intensity imposed more influence on drop sizes, and superficial flow rates of both phases are less able to the successful prediction of size distribution of droplets.
|
2022-09-03T15:55:13.399Z
|
92,536,797 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31073/AGROVISNYK201703-03",
"MAG": "2902760770",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose. To study of effect of insecticide Alpha Super on morphological dissociation of phytopathogenic bacteria Pseudomonas syringae pv. Atrofaciens (McCulloch 1920) Young, Dye and Wilkie 1978, causal organisms of bacterioses of cereal crops. Methods. Classical microbiological and biochemical methods, ability to form a biofilm is studied at growth of P. Syringae pv. atrofaciens in polypropylene trays. Results. It is fixed that insecticide Alpha Super is characterized by negligible toxicity to phytopathogenic bacteria P. syringae pv. atrofaciens . It is shown that at action of the specimen Alpha Super amount of R-forms of P. syringae pv. atrofaciens increases. Properties of the induced by insecticide Alpha Super R-forms of P. Syringae pv. atrofaciens UKM V-1011 are also studied. Conclusions. Insecticide Alpha Super causes morphological dissociation of phytopathogenic bacteria P. syringae pv. atrofaciens . R-forms of P. syringae pv. atrofaciens , induced by insecticide Alpha Super are characterized by greater resistance and form biofilms better, that increases surviving of these phytopathogenic bacteria in agrophytocenosis.
|
2022-10-27T16:01:27.703Z
|
25,067,217 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1751-1097.2010.00863.x",
"MAG": "2088563146",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Tin oxide nanoparticles about 4 nm in size were successfully synthesized using hydrothermal method. The photocatalytic activity of the particles was determined by the decolorization of malachite green (MG) and titanium yellow (TY) under UV light. 12 ppm of MG and TY were used for the solution with an initial volume of 100 mL. The amounts of catalysts were 10, 30 and 50 mg. The effect of the catalyst loading on the reaction kinetic parameters and the decolorization rate constants (k) were determined. In order to reveal the photocatalytic efficiency of the nano particles, further experiments were conducted with bulk SnO2. The oxygen species registered no observable effect on the reaction mechanism as nitrogen bubbling leads to no change in decolorization rates. Results showed that the synthesized nano tin oxide particles represent excellent photocatalytic activity for the decolorization of 12 ppm MG under UV light with 150 min of irradiation time. The energies of the highest occupied molecular orbital (HOMO) EHOMO of the dyes were also calculated by using the quantum chemical software in order to discuss the differences for the decolorization of two dyes. Electrical energy efficiency values for the decolorization of two dyes were also calculated.
|
2022-11-25T19:17:48.825Z
|
143,644,740 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1163/156851912X603193",
"MAG": "1977415185",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The present essay is an examination of classical jurists' legal determinations pertaining to liwāt (sodomy) and sihāq (tribadism), both of which have been little studied in their legal context. In exploring jurists' logic and legal categorizations, I argue that three major factors contributed to their legal injunctions: (1) their use of zinā (illicit sex between a man and a woman) as the paradigm by which to punish liwāt and sihāq, (2) their perception of sexual intercourse as an exclusively male act of phallic penetration, and (3) an individual's legal status within the social hierarchy as reflected in jurisprudential discussions of illicit sexual intercourse (zinā). Juristic disagreements over the semantics and definitions of these three factors extended to the treatment of liwāt and sihāq and, ultimately, became normative doctrine.
|
2022-12-06T19:14:33.290Z
|
123,052,434 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1175/1520-0469(1991)048<2461:SBDUTI>2.0.CO;2",
"MAG": "2092821720",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An Eady model modified to include Ekman dissipation and sloping horizontal boundaries is used to investigate the nonlinear evolution of baroclinic waves in the presence of surface topography. The effectiveness of the topography to phase lock and equilibrate a given mode vs that of baroclinity to propagate and vacillate that mode is found to depend on the topographic height, its zonal structure, and the level of supercriticality. When topography is sinusoidal and of the same wavelength as the baroclinically most unstable mode, it induces a short-period amplitude modulation whose envelope represents the baroclinic evolution. The dynamics of this modulation is explored analytically. When the sinusoidal topography is of a longer zonal wavelength, a 'mixed' wave state persists with amplitude dominance shifting between the topographic mode and the baroclinic mode, depending on the relative strength of form drag and baroclinicity. Model results are also compared, in appropriate parameter limits, with near-resonance asymptotic results and annulus experiments.
|
2022-12-10T09:03:50.069Z
|
635,635 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TASC.2017.2673780",
"MAG": "2590513153",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We devised a linear induction motor (LIM) that uses the close-ended coated superconductor coils as the secondary to explore the potential solutions of enhancing the thrust performance at large clearance, which is generally required for the linear propulsion of transit systems. In this proposal, the coated superconductor coils are embedded into a ferromagnetic yoke whose function is to guide and concentrate the travelling fields generated by the three-phase conventional stator. To make a preliminary study before the laboratory demonstration, we built a numerical model of this proposal by resorting to the finite-element software of MagNet, a recognized professional tool to simulate the electrical machines in the scientific community. Through a treatment of the power law, the developed numerical model has included the nonlinear constitutive law of superconductor, which is currently thought to be difficult in the MagNet environment. This general treatment takes a step forward toward the use of the professional software to perform complex simulations of the superconducting machines. Based on the numerical model, we carried out a set of transient studies on the proposed LIM to observe the distributions of travelling flux, the starting characteristics, and the time evolutions of thrust and speed. The achieved results clearly display that the proposed LIM has advantages over the conventional type and could be thereby regarded as a candidate for developing high thrust linear LIM with large clearance.
|
2022-12-17T22:21:43.406Z
|
203,938,194 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acsaem.9b01591",
"MAG": "2973650276",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The chemical stability of non-fullerene acceptors under acidic and basic environments is important because the printable electrodes and interfacial layers are typically acidic (such as PEDOT:PSS) or basic (such as PEI, or amine-stabilized ZnO nanoparticles). In this work, we report a reversible chemical reaction of non-fullerene acceptors (ITIC-family) under acidic and basic environments. OH– anions react as a nucleophile with C═C linkage of the donor and acceptor moieties of ITIC, resulting in a product of ITIC-OH. The reaction breaks the intramolecular charge transfer and destroys the photovoltaic performance. Furthermore, the ITIC-OH can be converted back to ITIC after adding H+. Thus, the non-fullerene acceptors are stable in an acidic environment, but not in a basic environment. This finding provides a guide for the design of interfaces for efficient and stable non-fullerene organic solar cells.
|
2022-12-26T16:48:58.902Z
|
218,554,314 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/07494467.2018.1453324",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/07494467.2018.1453324?needAccess=true"
}
|
The historical development of the now globalised practice of electroacoustic music has seen many different chapters and trajectories. Nowhere more than in East Asia has it been disjointed. Mostly for political and economic reasons, its acceptance has been greatly delayed in most of these countries. Only in Japan was it adopted quite early on. Composers in other countries and regions of East Asia have finally been able to investigate the possibilities of creating music with artificial sounds. This is why it is important today to consider the various elements which have influenced its propagation in that part of world. Electroacoustic music is not a genre: it is a set of musical possibilities which rely on the use of some sort of electronic technology. Thus, it is extremely diversified. Furthermore, composers and engineers often work together to search for ways of adapting the latest technical discoveries to achieve new methods of producing sounds, interacting with live performers, creating new musical forms, and experimenting with audio materials that have never been heard before. The technical environment is shared by all, yet the types of music composed in the various countries of East Asia are varied. It is because, in some cases, cultural background has the strongest influence, while for others, the attraction of modernity and even anticipation of the future is the main motivation behind experimentation. To reflect these attitudes, this issue ofContemporaryMusic Review has chosen to open its doors to local composers and scholars. The issue editors have asked a number of musicologists and scholars who live and work in East Asia to document some aspect of the rich and complex history of electroacoustic music in the region. Some, such as Hiromi Ishii and Lin-Ni Liao, have chosen to discuss the current trends. Others, such as Hefei Wang, Li Qiuxiao, and Naotoshi Osaka, have dealt with major events which accompanied the presentation of music to the public. An historical perspective has been illustrated by Cathy Cox with her translation of two major articles by Japanese pioneer Toshiro Mayuzumi, a composer further discussed by Yoshihiko Shimizu. Toshie Kakinuma,MikakoMizuno, as well as Hee Seng Kye and Jongwoo Yim have discussed, inmusicological terms, aspects of the evolution of electroacousticmusic. Finally, Xiaofu Zhang has presented from Beijing aesthetical aspects of composition in China. Because of these various contributions from China, Japan, Taiwan, and South Korea, the issue presents both historical accounts of how this music has spread in Contemporary Music Review, 2018 Vol. 37, Nos. 1–2, 1–3, https://doi.org/10.1080/07494467.2018.1453324
|
2022-01-27T01:29:06.596Z
|
195,823,305 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5152/trs.2016.389",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Tüm dünyada ölümlerin %10’una travma neden olmaktadır. Travma, maligniteler ve vasküler hastalıklardan sonra 3. sıklıkta görülen ölüm nedenidir. Araç kazaları (%75), abdomene direkt darbe (%15), yüksekten düşme (%6-9) ve daha az sıklıkta ev kazaları, penetran yaralanmalar ve iyatrojenik nedenler, abdominal travma nedenleri arasındadır. Penetran abdominal yaralanma nedenleri arasında kaza, homisid, iyatrojenik ve ateşli silah yaralanmaları sayılabilir [1-4]. Yaralanmalar; travmanın direkt veya hareket etkisi, kompresif etki, gerilme ve yırtılma etkisi ile oluşur. Solid organlarda kanama, içi boşluklu organlarda perforasyon, kanama ve peritoneal kontaminasyon gelişebilir. Retroperitoneal yaralanmalar, genelde başlangıçta asemptomatiktir [3]. Travmanın geldiği bölgeye göre sağ yanda; sağ hepatik lob, sağ böbrek, diyafragma, pankreas başı, duodenum, inferior vena kava (İVK), orta hatta; sol hepatik lob, pankreas gövdesi, aorta, transvers kolon, duodenum, ince barsak, sol yanda; dalak, sol böbrek, diyafragma, pankreas kuyruğu yaralanmaktadır [3, 4]. American College of Radiology (ACR), abdominal travmalı olguları kategorilere ayırmış, göreceli olarak daha stabil, görüntülemeye gönderilecek ve riskli, girişimsel veya cerrahi tedaviye hızla gönderilmesi gereken olguları sınıflandırmıştır. Son yıllarda, parankimal dokuyu koruma yaklaşımlı tedaviler benimsendiğinden, abdominal travmalı olgularda girişimsel radyolojik işlemlerin yeri ve önemi gittikçe artmaktadır [1-4].
|
2022-02-08T07:31:20.053Z
|
216,021,745 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1115/1.4046577",
"MAG": "3009754768",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In human–robot collaborative tasks, the performance of robot path planning has a direct impact on the robot-to-human hand-over process, or even the collaboration quality. In this work, we propose an evaluation study on multiple robot path planners with different metrics and reveal their pros and cons in representative human–robot collaborative manufacturing contexts. Afterward, based on the proposed metrics, we define a cost function for the dual-arm robot to choose optimized path planning solutions with maximum efficiency for its human partner in human–robot collaboration. We implement the proposed evaluation and optimization approaches to multiple realistic human–robot collaborative manufacturing contexts. Experimental results and evaluations suggest that our approaches are able to provide positive solutions for the robot path planner selection and also open a window for exploring more complicated and general robot path planning applications to human–robot collaborative tasks in smart manufacturing contexts.
|
2022-09-06T23:24:50.212Z
|
213,312,025 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3310373",
"MAG": "2997627242",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We present pretend synchrony, a new approach to verifying distributed systems, based on the observation that while distributed programs must execute asynchronously, we can often soundly treat them ...
|
2022-09-10T08:17:14.542Z
|
46,155,025 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1139/O66-156",
"MAG": "1998371173",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The excretion of fecal bile acids was determined in three adult males during the last 4 days of eight dietary periods of 8 days each, during which 35 to 60% of total calories was provided by corn oil or butterfat. The bile acids were identified and individually estimated by a combination of thin-layer and gas chromatography. The total output in two subjects on butterfat (three samples) was 165–288 mg/day, whereas a third subject on a similar diet (two samples) excreted only 38–57 mg/day. On corn oil, the latter subject excreted 37 mg/day of total fecal bile acid and, on mixed corn oil – butterfat diet, 120 mg/day. The low fecal bile acid output in this subject was comparable to that of one of the other two subjects (25 mg/day) on a hydrogenated corn oil diet. The qualitative fecal bile acid patterns were similar with both high-fat diets and resembled those observed earlier on fat-free regimens. Because of the large subject and sample variations, the significance of any quantitative differences in the feca...
|
2022-09-12T02:52:44.271Z
|
244,631,470 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1215/21599785-9015306",
"MAG": "3207775483",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article proposes that returning Denise Riley’s work on (and troubling of) the category of “women” offers a feminist theorizing and politics that remains both critical and relevant to the political present. It argues that reading Riley again, alongside other anti-essentialist feminist thinkers, reveals the distinctiveness, force, and capaciousness of her project, which lay in her attention to historicity, form, language, and affect. It is precisely the poetics of Riley’s feminist thought that sustain the critical orientation that must animate feminism’s utopian desires.
|
2022-09-13T21:01:01.176Z
|
80,143,959 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/0102-311X00187515",
"MAG": "2773163103",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Resumo: O presente estudo objetiva responder se o tempo de viagem a municipios polos regionais possui efeito na taxa de obitos por causas evitaveis (TOCE) e na taxa bruta de mortalidade padronizada (TBMP) em municipios com ate 5 mil habitantes do Rio Grande do Sul, Brasil. Sem a utilizacao de variaveis controles, o maior tempo de percurso ate municipios com 100 mil habitantes ou mais esta associado com um aumento de ambas as taxas. No entanto, enquanto que o comportamento da TOCE permanece similar apos a insercao dos controles, a TBMP inverte seu sinal, sugerindo que, mantendo as demais caracteristicas socioeconomicas e de atendimento de saude constantes, a distância a municipios polos esta associada, ao mesmo tempo, a uma reducao dos obitos por causas evitaveis e a um aumento nas demais causas de morte.
|
2022-11-25T00:19:42.559Z
|
41,481,327 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1749-6632.1994.tb17332.x",
"MAG": "2089475114",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The early atherosclerotic lesion is characterized by the presence of macrophage-derived foam cells. Macrophage colony-stimulating factor (M-CSF) specifically stimulates the functions of the monocyte-macrophages. To elucidate the role of M-CSF in the atherogenic process in vitro and in vivo, we studied the effects of M-CSF on enzyme activities of acidic cholesteryl ester (CE) hydrolase, neutral CE hydrolase, and acyl-coenzyme A:cholesterol acyltransferase (ACAT), and 300 micrograms of M-CSF was intravenously injected into WHHL rabbits aged 2.5 months for 8.5 months. M-CSF (100 ng/ml) enhanced acidic and neutral CE hydrolase, and ACAT activities by 3.2-fold, 4-fold, and 2.3-fold, respectively, in the presence of acetyl LDL, and M-CSF increased ratios of both acidic and neutral CE hydrolase activities to ACAT activity. After M-CSF injection into WHHL rabbits, we found very retarded progression of atherosclerosis. The accumulation of cholesterol ester was remarkably decreased in the aortae of M-CSF-treated animals (0.60 +/- 0.32 mg/g tissue), as compared to those of controls (4.21 +/- 0.65 mg/g tissue). The results suggest that M-CSF prevents the progression of atherosclerosis in WHHL rabbits by increasing net hydrolysis of cholesteryl ester in macrophages.
|
2022-12-19T15:30:04.857Z
|
120,403,772 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/02286203.2010.11442594",
"MAG": "1971701139",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract A mathematical model of magnetohydrodynamics (MHD) turbulent boundary layer fluid flow past a vertical infinite plate in a dissipative fluid with Hall current is considered. The plate is impulsively started and the flow problem is analysed thereafter. The effect of Hall current on the convectively cooled or convectively heated plate in the turbulent boundary layer is investigated. The Reynolds stresses, arising due to turbulence, in the momentum equations are resolved using Prandtl mixing length hypothesis. The governing equations for the problem are solved by a finite difference method. An analysis of the effects of Hall current, viscous dissipation and time on velocity and temperature profiles is done with the aid of graphs. It is found that primary velocity increases with increase in Hall parameter.
|
2022-07-31T13:22:08.964Z
|
202,959,837 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18290/rt.2019.66.1-1",
"MAG": "2971224868",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://ojs.tnkul.pl/index.php/rt/article/download/3771/3651"
}
|
Celem artykułu jest ukazanie fundamentalnych zasad regulujących politykę społeczną i ich wpływu na wyznawane wartości, motywacje i wzorce działań wspólnotowych członków zbiorowości. Na podstawie badań empirycznych autorka wskazuje aksjologiczne zakorzenienie, motywacje i wzorce działania badanych mieszkańców, upatrując w anomijnym ich charakterze słabości lokalnej polityki społecznej.
|
2022-01-27T05:49:41.946Z
|
229,080,595 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26739/2181-9491-2020-6-8",
"MAG": "3105101789",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This article discusses the role and importance of leasing in the economic development of the Republic of Uzbekistan, as well as the problems associated with investment in leasing and their solutions The purpose of the study is to develop conclusions, proposals and recommendations to improve the efficiency of leasing activities in improving the investment process in Uzbekistan
|
2022-02-07T23:02:08.686Z
|
79,597,842 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12681/eadd/40826",
"MAG": "2625445515",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Τα ερυθροκύτταρα των ασθενών με χρόνια νεφρική ανεπάρκεια (ΧΝΑ) τελικού σταδίου που υποβάλλονται σε θεραπεία αιμοκάθαρσης παρουσιάζουν σημαντικές μεταβολές τόσο στο αιματολογικό πρότυπο σε σχέση με υγιή άτομα όσο και σε χαρακτηριστικά των ερυθροκυττάρων σε επίπεδο οξειδωτικού στρες, μορφολογίας, ερυθρόπτωσης, πρωτεϊνικής σύστασης καθώς και αλλαγές σε χαρακτηριστικά του πλάσματος. Η ανθεκτικότητα στην ερυθροποιητίνη έχει συσχετισθεί με ερυθροκυτταρικές βλάβες χωρίς όμως να έχει μελετηθεί ενδελεχώς αυτός ο μηχανισμός αλληλεπίδρασης. Όσον αφορά στην αιμοκάθαρση, εκτός από τη σημαντική επίδραση που έχει στο προσδόκιμο ζωής των ασθενών με ΧΝΑ και στην αντιμετώπιση της αναιμίας, έχει σημαντική επίδραση και σε χαρακτηριστικά των ερυθροκυττάρων τα οποία σχετίζονται με την εμφάνιση αναιμίας.Στόχος της παρούσας μελέτης υπήρξε η λεπτομερής ανάλυση σε κυτταρικό επίπεδο των ερυθροκυττάρων και του πλάσματος ασθενών με ΧΝΑ τελικού σταδίου υπό συμβατική αιμοκάθαρση οι οποίοι λαμβάνουν πολύ υψηλές δόσεις ερυθροποιητίνης σε σύγκριση με ασθενείς που λαμβάνουν φυσιολογικές δόσεις, με απώτερο στόχο την εύρεση των τροποποιήσεων που προκύπτουν ως αποτέλεσμα της περίσσειας ερυθροποιητίνης στο αίμα των ασθενών. Επιπλέον, μελετήθηκε η επίδραση μιας σχετικά νέας μεθόδου κάθαρσης, της αιμοδιαδιήθησης, σε σχέση με τη χρόνια εφαρμοζόμενη συμβατική αιμοκάθαρση για την εύρεση των επιδράσεων αυτής της μεθόδου στο βαθμό αναιμίας των ασθενών, μέσα από τη μελέτη του αιματολογικού προτύπου αλλά και χαρακτηριστικών των ερυθροκυττάρων και του πλάσματος.Εκτός από τον κλασσικό αιματολογικό και βιοχημικό έλεγχο, στο πλάσμα μετρήθηκε η ολική αντιοξειδωτική ικανότητα με δοκιμασία αναγωγής τρισθενούς σιδήρου (FRAP assay), η ελεύθερη αιμοσφαιρίνη (αιμόλυση) κατά Harboe καθώς και ο πληθυσμός των ολικών και ερυθροκυτταρικών μικροκυστιδίων με κυτταρομετρία ροής. Στα ερυθροκύτταρα, η μορφολογική εκτίμηση έγινε με Ηλεκτρονική Μικροσκοπία Σάρωσης, η πρωτεϊνική σύσταση της ερυθροκυτταρικής μεμβράνης με ανοσοαποτύπωμα κατά Western, η μέτρηση των ενδοκυττάριων επιπέδων ROS και ιόντων ασβεστίου διενεργήθηκε με φθορισμομετρία και τα επίπεδα εξωτερίκευσης φωσφατιδυλοσερίνης ανιχνεύθηκαν με κυτταρομετρία ροής. Επιπλέον, στα ερυθροκύτταρα πραγματοποιήθηκε μέτρηση της οσμωτικής και μηχανικής ευθραυστότητας. Η άμεση επίδραση του ουραιμικού πλάσματος στα ερυθροκύτταρα μελετήθηκε in vitro με πειράματα ανασύστασης. Ακολούθησε στατιστική επεξεργασία των αποτελεσμάτων και ανάλυση δικτύων.Γενικά, τα ουραιμικά ερυθροκύτταρα χαρακτηρίζονται από παθολογικές μορφολογικές τροποποιήσεις, δείκτες απομάκρυνσης από την κυκλοφορία και αυξημένα επίπεδα κυστιδιοποίησης. Μάλιστα, τα επίπεδα των μη αναστρέψιμων μορφολογικών τροποποιήσεων επηρεάζονται σε κάποιο βαθμό από τα επίπεδα αιμοσφαιρίνης αίματος των ασθενών. Η μειωμένη ανταπόκριση στη θεραπεία με ερυθροποιητίνη σχετίζεται μεαυξημένα επίπεδα ουραιμικών τοξινών στο πλάσμα, ανεπάρκεια πρωτεϊνών CD59 και κλαστερίνη, αυξημένη πρόσδεση της υπεροξειρεδοξίνης-2 στη μεμβράνη ενώ η αιμοκάθαρση επιφέρει σημαντική αύξηση των επιπέδων εξωτερίκευσης φωσφατιδυλοσερίνης. Αντίθετα, η ανταπόκριση στη θεραπεία σχετίζεται με παθολογικάυψηλή αιμόλυση, μειωμένη ανθεκτικότητα στο μηχανικό στρες, αυξημένη πρόσδεσηανοσοσφαιρινών G στη μεμβράνη και ανεπάρκεια του μορίου CD47, ενώ η διαδικασία της αιμοκάθαρσης οδηγεί σε σημαντική αναδιαμόρφωση της μεμβράνης. Όσον αφορά στη μελέτη των δύο διαφορετικών μεθόδων κάθαρσης, η χρόνια θεραπεία σε αιμοδιαδιήθηση οδηγεί σε αποτελεσματική αντιμετώπιση της αναιμίας, βελτίωση του οξειδοαναγωγικού δυναμικού των ερυθροκυττάρων και καταστολή της κυστιδιοποίησης σε σχέση με τη συμβατική αιμοκάθαρση. Αντίθετα, οι άμεσες επιδράσεις της αιμοδιαδιήθησης περιλαμβάνουν αύξηση του οξειδωτικού στρες, παθολογική αιμόλυση, αύξηση δεικτών απομάκρυνσης από την κυκλοφορία και εμφάνιση στοματοκυττάρωσης.Συμπερασματικά, το περισσότερο τοξικό ουραιμικό περιβάλλον που χαρακτηρίζει τους μη ανταποκρινόμενους ασθενείς σε σχέση με τους ανταποκρινόμενους, αντιμετωπίζεται εν μέρει από τις αντιοξειδωτικές, αντι-αιμολυτικές και αντι-αποπτωτικές ιδιότητες της ευθροποιητίνης και του ουρικού οξέος. Η αναιμία στους μη ανταποκρινόμενους ασθενείς φαίνεται να σχετίζεται κυρίως με ανεπάρκεια πρωτεϊνών που αναστέλουν την ενεργοποίηση του συμπληρώματος, ενώ στους ανταποκρινόμενους με επιταχυνόμενο φαινότυπο γήρανσης και αυξημένη ερυθροφαγοκυττάρωση. Τέλος, υπάρχουν ενδείξεις για διαφορετικό μηχανισμό κυστιδιοποίησης των ερυθροκυττάρων ανάμεσα στις δύο ομάδες των ασθενών. Αντίστοιχα, η θεραπεία σε αιμοδιαδιήθηση μακροπρόθεσμα οδηγεί σε βελτίωση της αναιμίας και των ερυθροκυτταρικών παραμέτρων σε σχέση με τη συμβατική αιμοκάθαρση. Οι αρνητικές επιπτώσεις που παρατηρούνται μετά το τέλος της συνεδρίας κάθαρσης στην αιμοδιαδιήθηση φαίνεται να σχετίζονται με την απώλεια χρήσιμων αντιοξειδωτικών συστατικών του αίματος ταυτόχρονα με την απομάκρυνση των ουραιμικών τοξινών. Η θεραπεία με αντιοξειδωτικά φάρμακα κατά τη διάρκεια της συνεδρίας ή η χρήση κατάλληλων φίλτρων εμπλουτισμένων σε βιταμίνες θα μπορούσε να αναστείλλει τις αρνητικές επιπτώσεις που έχει, έστω και προσωρινά, η θεραπεία της αιμοδιαδιήθησης.
|
2022-04-08T00:38:50.127Z
|
74,369,540 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17940/ed.58708",
"MAG": "2203721663",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background and Aims: The aim of this study is to investigate the factors that have an affect on colon cleaning when nap was used before colonoscopy for intestinal cleanliness and evaluate how our society perceives the colonoscopy prosedure by way of a public survey. Materials and Method: This study was carried out in Ankara University School of Medicine Cebeci Hospital Endoscopy Center between the dates August 2008 and March 2009. The cleanliness degree of colon was scored in colonoscopy procedure. All patients were questioned by the nurse with a survey before and after the prosedure. Results: The average age of the104 patients that have taken the survey was 52.3 (21-82) SD 14.1. There were no age differences between groups of high and low education levels (p=0.410), and (n=59) 56.2% of the patients surveyed were women, (n=45) 42.9% were men. There were no sex differences between groups of high and low education levels. In 6 patients intestinal cleanliness was bad, in 36 patients intestinal cleanliness was acceptable, in 62 patients intestinal cleanliness was good-perfect.The most commonly seen side effects were stomach ache 30% and nausea 32,8%, for both groups. For all patients stomach ache and nausea were mild. There were no meaningful statistical differences (p=0.203) found in adaptation to preliminary diet (p=0.07) and in quality of intestinal cleanliness between low education level patients (n=68) and high education level patients (n=36). Only 8 of 104 patients had taken the colonoscopy procedure for colorectal cancer scanning. Before the procedure , when patients were asked; 14 of the 36 in high education level patients and 45 of 68 in low education level patients said they were embarrassed because of the procedure (p=0.08). Conclusion: There were no connections found between different education levels and adaptation of preliminary colonoscopy diet and intestinal cleanliness before the colonoscopy. We have also concluded that in asymptomatic individuals over 50 years of age in our society do not pay necessary attention to scanning programs and according to the result of the survey evaluation, it is difficult for a considerable number of people to be psychologically comfortable with the colonoscopy procedure.
|
2022-05-29T23:57:14.554Z
|
250,158,989 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ted.2022.3184658",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This work reports the development of a gallium nitride-based high electronic mobility transistor (GaN HEMT)-based biosensor to detect human epidermal growth factor receptor-2 (HER2) antigen in spiked human serum. The platform devices have been fabricated with a source to drain distance, gate length, and unit gate width of 25, 3, and <inline-formula> <tex-math notation="LaTeX">$100 ~\mu \text{m}$ </tex-math></inline-formula>, respectively. The cysteine methyl ester (CME)-based chemistry has been utilized to immobilize the antiHER2 antibody on the sensing region of the sensor. The formation of the CME layer was confirmed through Raman spectroscopy, which shows a peak around a wavelength of 262 cm<sup>−1</sup>. The antibody immobilization on the gold surface has been confirmed through enzyme-linked immunosorbent assay (ELISA). The sensor has been electrically characterized before and after each step of the functionalization process. The sensor shows a significant change in the drain current of 0.95 and 1.7 mA at a <inline-formula> <tex-math notation="LaTeX">${V}_{{\mathrm {ds}}} $ </tex-math></inline-formula> of +5 V for 50- and 200-ng/ml concentration of HER2 in spiked human serum. A minor change in the drain current of the sensor, when tested with a nonspecific antigen, suggested the high specificity of the sensor for HER2. The sensor has been tested for a broad range concentration of HER2 antigen from 0.7 pg/ml to 200 ng/ml.
|
2022-08-06T01:34:31.648Z
|
146,577,551 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17763/HAER.77.3.N5MRM15708528701",
"MAG": "2194839724",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Children’s Defense Fund. (2004). The state of America’s children 2004: A continuing portrait of inequality fifty years after Brown v. Board of Education. Washington, DC: Children’s Defense Fund. Cohen, J. (1999). Educating minds and hearts: Social emotional learning and the passage into adolescence. New York: Teachers College Press. Eisler, R., & Miller, R. (2004). Educating for a culture of peace. Portsmouth, NH: Heinemann. Elias, M., Zins, J. Weissberg, R., Frey, K., Greenberg, M., Haynes, N., et al. (1997). Promoting social and emotional learning: Guidelines for educators. Alexandria, VA: Association for Supervision and Curriculum Development. Elliot, D., Hamburg, B., & Williams, K. (1999). Violence in American schools. Cambridge, England: Cambridge University Press. Galtung, J., and Jacobsen, C. (2000). Searching for peace. Sterling, VA: Pluto Press. Gassin, E., Enright, R., & Knutson, J. (2005). Bringing peace to the central city: Forgiveness education in Milwaukee. Theory Into Practice, 44, 303–318. Gladden, M. R. (2002). Reducing school violence: Strengthening student programs and addressing the role of school organizations. In W. G. Secada (Ed.), Review of research in education, 2002. Washington, DC: American Educational Research Association. Global Peace Index (2007). Retrieved July 27, 2007, from http://www.visionofhumanity. com/rankings/ Harris, I. (2000). Peace-building responses to school violence. Bulletin: The National Association of Secondary School Principals, 84, 5–24. Harris, I., & Morrison, M. (2003). Peace education (2nd ed.). Jefferson, NC: McFarland. Harris, I., & Shuster, A. (2006). The global directory of peace and conflict studies programs (7th ed.). San Francisco: Peace and Justice Studies Association. Iram, Y. (2006). Educating toward a culture of peace. Greenwich, CT: Information Age. Lamberg, L. (1998). Preventing school violence: No easy answers. JAMA, 280, 404–407. Lantieri, L., & Patti, J. (1996). Waging peace in our schools. Boston: Beacon Press. Prothrow-Stith, D. (1991). Deadly consequences. New York: Harper Collins. Reardon, B. (1988). Comprehensive peace education. New York: Teachers College Press. Sandy, S. (2001). Conflict resolution in schools: Getting there. Conflict Resolution Quarterly, 19, 237–250. Scanlon, D. (1959). The Pioneers of International Education: 1817–1914, Teachers College Record, 4, 210– 219. Stomfay-Stitz, A. (1993). Peace education in America 1828–1999: Sourcebook for education and research. Metuchen, NJ: Scarecrow Press. Wax, E. (2000, October 4). Educating more than the mind. Washington Post, p. B1. Woolman, D. (2002). The quest for international understanding in United States education. Social Alternatives, 21(1), 23–27.
|
2022-09-08T05:07:02.548Z
|