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255M
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236,232,583 |
{
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"DOI": "10.1504/GBER.2021.10038702",
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|
Despite being extensively researched since audit committees emerged early in the 20th century, the focus has tended to be on public sector organisations and large listed public companies. This paper uses an explorative qualitative case-study research design, to understand the impact of the characteristics of audit committee member on audit committee effectiveness in a purposively selected small to medium-sized company. The paper provides important insights into the impact of audit committee member qualifications, experience and independence, on how the audit committee discharges its responsibilities. Although the leadership of the audit committee chairperson appears to have enhanced governance practices, the atypical role of mentoring the newly appointed chief financial officer, questions whether the audit committee chairperson, and accordingly the audit committee, is truly independent, or whether it has succumbed to the familiarity threat. Despite its South African orientation, the worldwide importance of small to medium-sized enterprises gives the study globally relevance.
|
2022-07-09T01:41:54.950Z
|
13,393,703 |
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"DOI": "10.1109/VLSIT.2002.1015414",
"MAG": "1827752745",
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|
For the first time, MIS capacitors with HfO/sub 2/-Al/sub 2/O/sub 3/ laminate are successfully demonstrated. The effective oxide thickness (EOT) of 21 /spl Aring/ with an acceptably low leakage current has been achieved for a cylinder-type MIS capacitor. The EOT of 21 /spl Aring/ is the smallest value reported for MIS capacitors with TiN electrodes regardless of dielectric material. We have confirmed the feasibility of reducing EOT in spite of the simple process without a pre-deposition treatment. HfO/sub 2/-Al/sub 2/O/sub 3/ laminate is also useful for SIS capacitors and can satisfy the needs of MIM capacitors for the next generation without changing electrode material.
|
2022-09-14T00:17:56.848Z
|
110,947,898 |
{
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"ArXiv": null,
"DOI": "10.1109/APEC.1999.750459",
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|
This paper addresses the issue of current sampling in high performance AC motor drive systems fed by a discontinuous PWM inverter. The effect of the sampling error due to the measurement delay produced by the low pass filter and A/D converter is described in case of discontinuous PWM. To compensate the error, a method to estimate the delay time of the whole measurement system based on the measured current is proposed and its effectiveness is verified by experimental results. The proposed algorithm can automatically estimate the system delay introduced by low pass filter and A/D converter at the commissioning stage. Through delaying the current sampling by the estimated value, experimental results reveal more than 50% reduction of current ripples.
|
2022-09-14T22:14:57.198Z
|
23,129,057 |
{
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"ArXiv": null,
"DOI": "10.1097/00004872-199503000-00003",
"MAG": "2087431473",
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"url": null
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|
Objective and design Ambulatory blood pressure monitoring is being used increasingly in clinical practice and hypertension research. We have noted elevated blood pressure during the initial hours of monitoring. The objective of the present study was to examine the consistency, magnitude and duration of this elevation, and to determine whether this effect causes significant differences in the mean ambulatory blood pressure monitoring values comparing the first (day 1) and second (day 2) consecutive 24-h periods of monitoring. Methods Fifty patients who were hypertensive based on repeated clinic readings were studied prospectively. Each underwent continuous 48-h ambulatory blood pressure monitoring with a SpaceLabs 90207 monitor. The device recorded blood pressure at 15-min intervals during the daytime (0600–2159 h) and at 30-min intervals at night-time (2200–0559 h). From these readings hourly means were calculated. Repeated-measures analysis of variance was performed to compare the hourly means of days 1 and 2. Results Repeated-measures analysis of variance indicated that a significant difference existed for both systolic and diastolic blood pressure between day 1 and day 2. Paired Student's t-test revealed that this difference occurred during the first 2 h of monitoring. The daytime blood pressure was higher on day 1 as a result of the initial elevation of blood pressure at the onset of monitoring. The initial elevation of blood pressure was present both in white-coat hypertensives and in essential hypertensives. Conclusion The first 2 h of ambulatory blood pressure monitoring are associated with elevated blood pressure both in white-coat hypertensives and in essential hypertensives. This has a minor effect on mean daytime and 24-h ambulatory blood pressures. We propose that improved ambulatory blood pressure monitoring recordings would be obtained in clinical practice, and more particularly in research applications, if 26-h ambulatory blood pressure monitoring was carried out, excluding the first 2 h from the summary analyses.
|
2022-09-15T00:45:46.366Z
|
144,362,069 |
{
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"DOI": "10.5388/AON.2013.13.1.43",
"MAG": "3145270576",
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|
Purpose: This study has attempted to comparatively analyze the parenting stress that parents of a child with leukemia and their information needs at the end of treatment after complete remission (CR) of leukemia. Methods: For data collection, a structured questionnaire survey on parenting stress and information needs was conducted using parents of children with leukemia visiting the Blood & Marrow Transplantation Center at C University Hospital in Seoul from August to December 2011. A total of 100 parents were examined. Results: The parents of children under treatment after CR had greater parenting stress than parents of children whose treatment was finished. The parents of children whose treatment was finished had greater information needs than the parents of children whose treatment was ongoing. The differences had no statistical significance. In both groups, information needs about patients’ growth development and school adjustment was high. Conclusion: This study confirms that it is necessary to add information about daily life management, child’s growth development, sociopsychological adaptation, school adjustment, and support of family, to the current symptom care-centered education program.
|
2022-12-02T04:20:54.391Z
|
207,395,335 |
{
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"ArXiv": null,
"DOI": "10.1503/cmaj.091113",
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},
"license": "CCBYNCND",
"status": "GOLD",
"url": "http://www.cmaj.ca/content/cmaj/182/16/1723.full.pdf"
}
|
Background: Acupuncture is frequently advocated as an adjunct treatment during stroke rehabilitation. The aim of this review was to assess its effectiveness in this setting. Methods: We searched 25 databases and 12 major Korean traditional medicine journals from their inception to October 2009. We included randomized controlled trials, with no language restrictions, that compared the effects of acupuncture (with or without electrical stimulation) with sham acupuncture. We assessed the methodologic quality of the trials using the Cochrane risk-of-bias criteria and the PEDro (Physiotherapy Evidence Database) scale. Results: Ten of 664 potentially relevant studies met our inclusion criteria. For acute and subacute stages after stroke, we included seven trials. A meta-analysis of the five studies that assessed functionality did not show a significant difference in favour of acupuncture, with high heterogeneity. A post-hoc sensitivity analysis of three trials with low risk of bias did not show beneficial effects of acupuncture on activities of daily living at the end of the intervention period (n = 244; standard mean difference 0.07, 95% confidence interval [CI] −0.18 to 0.32; I2 = 0%) or after follow-up (n = 244; standard mean difference 0.10, 95% CI −0.15 to 0.35; I2 = 0%). For the chronic stage after stroke, three trials tested effects of acupuncture on function according to the Modified Ashworth Scale; all failed to show favourable effects. Interpretation: Our meta-analyses of data from rigorous randomized sham-controlled trials did not show a positive effect of acupuncture as a treatment for functional recovery after stroke.
|
2022-12-14T23:58:30.024Z
|
56,095,540 |
{
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"ArXiv": null,
"DOI": "10.1039/B908708G",
"MAG": "2012351732",
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"url": null
}
|
Pyrene-substituted polyhydromethylsiloxanes (PHMS-Pyx) were synthesised by the hydrosilylation reaction of prop-3-enyloxymethylpyrene with polyhydromethylsiloxane (Mn = 3700). The ratio of pyrene substituent to Si–H unit was varied to afford a range of pyrene-functionalised polysiloxanes. These copolymers were subsequently incorporated into polydimethylsiloxane (PDMS) elastomers by curingvia either Pt(0) catalysed hydrosilylation with divinyl-terminated PDMS (Mn = 186) and tetrakis(dimethylsiloxy)silane, or Sn(II) catalysed condensation with α,ω-dihydroxyPDMS (Mn = 26 000) and tetraethoxysilane. An alternative method involving the synthesis and integration of [3-(pyren-1-ylmethoxy)propyl]triethoxysilane (Py-TEOS) into PDMS elastomers was also investigated: a mixture of α,ω-dihydroxyPDMS (Mn = 26 000), tetraethoxysilane, and Py-TEOS was cured using an Sn(II) catalyst. Certain of the resulting fluorescent pyrene-labelled elastomers were studied by differential scanning calorimetry and dynamic mechanical analysis. No significant changes were observed in the thermal or mechanical properties of the elastomers containing pyrene when compared to otherwise identical samples not containing pyrene. All of the pyrene-containing elastomers were demonstrated to be fluorescent under suitable excitation in a photoluminescent spectrometer. Two of the elastomers were placed in a photoluminescence spectrometer and subjected to cycles of extension and relaxation (strain = 0–16.7%) while changes in the emission spectra were monitored. The resulting spectra of the elastomer containing the PHMS-Py50 copolymers were variable and inconsistent. However, the emission peaks of elastomers containing Py-TEOS displayed clear and reproducible changes in fluorescence intensity upon stretching and relaxation. The intensity of the monomer and excimer emission peaks was observed to increase with elongation of the sample and decrease upon relaxation. Furthermore, the ratio of the intensities of the excimer : monomer peak decreased with elongation and increased with relaxation. In neither case was there appreciable hysteresis, suggesting that fluorescent labelling of elastomers is a valid approach for the non-invasive in situ monitoring of stress and strain in such materials.
|
2022-12-17T15:13:49.873Z
|
197,585,894 |
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"DOI": "10.1029/2019EF001216",
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|
Surge hazards induced by tropical cyclones have caused substantial economic losses and casualties for coastal communities worldwide. Under projected sea level rise (SLR), it is not well understood how the probabilistic surge hazard may change. Coastal planning and engineering usually adopt the “bathtub” method to evaluate the surge‐SLR response, where surge with SLR is considered to be the exact summation of the two. This method has been shown by previous studies to be unreliable. Studies on surge‐SLR response either use a low‐fidelity model setup or rely on individual storm's surge to represent the probabilistic surge due to the high computational burden. Herein, we use high‐fidelity numerical models in the Tampa region, West Florida, consider 188 synthetic storms and four SLR scenarios, and investigate the surge‐SLR response and its physical drivers. Compared to the direct summation of present‐day surge and SLR amount, results show that the probabilistic surge with SLR can be 1.0 m larger, while different individual storm's surge with the same magnitude can be 1.5 m larger or 0.1 m smaller, indicating the importance of not relying on a limited number of surge events to assess the probabilistic surge response to SLR. Investigation of the physical drivers shows that distinct topographic features of the study area and storm forward speed notably affect the surge‐SLR response. When considering 1.3 m or larger SLR in the study area, complex topography, and large surge events, the effects of SLR on the probabilistic surge are hard to predict and should be investigated more carefully.
|
2022-12-28T14:48:22.886Z
|
158,730,735 |
{
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"DOI": "10.16908/ISSN.1660-7104/308",
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"url": null
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|
A l'instar de nombreux pays industrialises, le cancer du sein est a Geneve le cancer le plus frequent (environ 460 cas par an) et la premiere cause de deces chez les femmes entre 45 et 55 ans. Depuis mars 1999, le Programme genevois de depistage du cancer du sein a pour missions de promouvoir, d'organiser et de mener une action de prevention aupres de la population feminine du canton âgee de 50 a 69 ans.Ce rapport decrit l'evolution de 15 ans d'activite de depistage (chapitre 2) et analyse l'utilisation (chapitre 3), la qualite (chapitre 4) et l'efficacite (chapitre 5) du programme genevois entre 2007 et 2011. Couvrant 86'720 mammographies et pres de 37'000 femmes, ce rapport s'interesse aussi, au-dela des indicateurs usuels de performance, a mieux estimer certains effets indesirables comme les resultats faussement positifs ou les cancers survenant entre 2 examens de depistage (dits cancers d'intervalle).
|
2022-08-27T03:12:44.320Z
|
202,177,037 |
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"DOI": "10.2307/j.ctvndv846.10",
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"status": "GREEN",
"url": "https://research-repository.griffith.edu.au/bitstream/10072/389149/5/Tacon268033Published.pdf"
}
|
In 2001 we began The Landscape of Blue Mountain Rock Art research project. Since then, over 250 rock art sites have been recorded in Wollemi National Park, consisting of engravings, drawings, stencils and some paintings. Two of the largest, best preserved and culturally significant sites are Eagle’s Reach, with drawings and stencils, and Gallery Rock, an engraved platform. Although images were made using very different techniques there are many common subjects and stylistic features between the sites. Each location also shares imagery with smaller sites across southern Wollemi, where most research has been undertaken. For contemporary Aboriginal people of the Greater Blue Mountains World Heritage Area these two sites are highly significant as inter-related cultural places that are focal points within larger cultural landscapes. In this paper, we report the contemporary cultural significance of Gallery Rock and articulate its relationship to Eagle’s Reach and other nearby rock shelter art sites. Discussion focuses on the interpretation of some figures as key Ancestral Beings and whether some, such as Baiame, have a pre-European settlement context, something of great interest to John Clegg who visited Gallery Rock in 2007.
|
2022-09-07T08:45:40.449Z
|
56,664,057 |
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"DOI": "10.1300/J123v38n01_10",
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}
|
Abstract
|
2022-09-10T12:02:31.097Z
|
9,834,086 |
{
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"DOI": "10.1046/J.1365-2648.2002.02097.X",
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|
BACKGROUND
In young, non-toilet-trained children, the collection of a urine sample for microbiology can be challenging, with the application of a urine bag being the main method of collection. However, recent research has shown that absorbent pads can be used yielding similar results to bag specimens. However, weaknesses in study design erode confidence in research findings. Therefore, improvements in research design are required to fully evaluate the reliability of pad collection.
AIMS OF THE STUDY
This pilot study sought to test the feasibility of a technique for the collection of concurrent bag/pad urine samples from non-toilet-trained children, and to assess the reliability of urine pads over bags as a collection method for urine specimens for microbiological evaluation.
DESIGN
A pilot, method comparison study.
METHODS
Twenty concurrent bag and pad specimens were collected from non-toilet-trained children, following parental consent. Urine specimens were analysed for presence or absence of white cell count (WBC), and bacterial growth, using standard laboratory methods.
DATA ANALYSIS
The Kappa (kappa) statistics and confidence interval (CI) estimation were used to assess agreement between the two collection methods.
RESULTS
Despite concurrent samples there was a lack of agreement between bag and pad specimens on both main outcome measures. Agreement between bag and pad specimens for the presence of WBC yielded a kappa=0.10 (95% CI: 0.19, 0.39), indicating poor agreement, while a kappa of 0.5 (95% CI: 0.12, 0.88) was calculated for the degree of agreement in bacterial growth reflecting moderate agreement. Differences in proportions of the presence of WBC between bag and pad did not quite reach significance at the 5% level 0.2 (95% CI: 0.00, 0.42, P=0.062). For cultures the difference was calculated as 0.15 (95% CI: 0.05, 0.35, P=0.125).
CONCLUSION
The pilot study demonstrates that concurrent urine samples can be obtained without difficulty. Despite poor to moderate agreement on outcome measures the level of agreement is greater than reported in those other studies, that use non-current methods of urine collection, suggesting an advantage of the concurrent technique. It is recommended that larger scale studies be undertaken using the concurrent collection technique to assess reliability of these findings.
|
2022-09-12T05:55:24.186Z
|
154,488,464 |
{
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"ArXiv": null,
"DOI": "10.1111/J.1744-7976.1967.TB02390.X",
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|
The class shares of income in the Canadian economy and public policy developments are closely related. A comparison of the levels and trends in functional income shares with those in the United States economy generates a number of testable hypotheses. In this paper, the functional shares in all Canadian agriculture and agricultural regions are also observed and compared to US. agriculture and adjacent type of fanning regions.
The analysis indicates a marked similarity in the total economy income shares despite dissimilar factor supply functions. In both countries there has been a slight upward trend in the labor share over time. The rate and pattern of growth has also been similar in the two countries; however, a serious divergence has developed in recent years. In contrast to the total economies, declining farm labor income shares characterize both agricultures. Real estate shares also have followed a similar pattern in the two countries, with the past two decades witnessing a reversal in the historical decline. Nevertheless, there are a number of differences between factor shares in Canadian and United States agriculture. In part, these can be explained by comparing adjacent regions. It is clear, however, that the different impact of technological change and economic growth has bad a great impact on regional shares. The operation of capital and labor markets within Canadian agriculture also contribute to the differences in agricultural factor shares between the two countries.
|
2022-09-18T16:21:48.300Z
|
129,292,497 |
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"DOI": "10.2478/s13386-011-0041-6",
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"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://content.sciendo.com/downloadpdf/journals/geochr/38/3/article-p282.pdf"
}
|
Archaeological studies in the upper and lower part of the Ganga-Bhaghrathi-Hugli delta were taken up to understand the nature of site formation and human adaptation in a dynamic fluvial zone. This aspect has been neglected in Indian archaeology. However archaeological dating using typological information, has an error margin of a couple of centuries and hence, is of limited use. We suggest that high resolution chronology using Optically Stimulated Luminescence (OSL) and radiocarbon dating can be quite effective in the study of archaeology and human environment relationship in the Ganga-Brahmaputra Delta (GBD).
|
2022-11-12T19:33:04.735Z
|
85,404,321 |
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"ArXiv": null,
"DOI": "10.1080/01647950708684513",
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}
|
Abstract Eutarsopolipus shpeleyi n. sp. (Acari: Podapolipidae) is described from the carabid beetle, Pterostichus luctuosus Dejean (Carabidae), from Michigan, U.S.A. and compared with E. pterostichi, E. vernalis, E. inermis, E. diunculosus and E. fischeri in the pterostichi group of Eutarsopolipus. This is the third record of Eutarsopolipus and the first record of Eutarsopolipus in the pterostichi group from the carabid genus Pterostichus in North America.
|
2022-12-25T21:34:11.970Z
|
170,013,325 |
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"DOI": "10.12737/ARTICLE_5C6CFECE4E0F57.90216256",
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|
Th e article is devoted to the problems of social control in accounting. Based on the ethical principles of scientifi c activity, the current state of the national accounting system is analyzed, problems associated with the fundamental possibility of conducting basic research in accounting are identifi ed.
|
2022-02-08T17:33:27.795Z
|
199,040,113 |
{
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"DOI": "10.5005/jp-jogi-6-1-16",
"MAG": "2956652794",
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},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.5005/jp-jogi-6-1-16"
}
|
Antibiotic resistance has been an emerging concern for common bacterial infections worldwide. Helicobacter pylori, commonly associated with chronic bacterial infections, is also included in bacteria with drug resistant problems. Its infection, once considered curable, is now becoming a matter of grave concern with rising antibiotic resistant patterns reported worldwide. Resistance is mainly reported to the key antibiotics in the treatment of infection i.e. metronidazole and clarithromycin, and to a lesser extent to amoxicillin and tetracyclin, thereby decreasing the cure rates of the combination therapies used. Recently resistance to quinolones has also been reported. Pattern of antibiotic resistance in Helicobacter pylori Preeti Chaudhary, Varsha Gupta, Atul Sachdev Department of Microbiology Government Medical College & Hospital, Sector-32, Chandigarh.
|
2022-01-27T05:21:05.075Z
|
98,051,332 |
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"ArXiv": null,
"DOI": "10.1021/CG801132R",
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}
|
A new synthon involving carboxylic acid and a secondary amide with anti geometry has been identified and used as a designing element to engineer the cocrystals of symmetrically substituted triamides, tricarboxylic acids, and aromatic guest molecules. The robustness of the synthon has been explored by considering the pyridine functional groups in the amide molecules.
|
2022-09-13T21:53:25.208Z
|
52,102,165 |
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"DOI": "10.1590/S1516-35982013001000005",
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|
The objective was to investigate the effects of sex-sorting on early fertilization events in ovum pick up (OPU) derived oocytes fertilized in vitro with frozen-thawed sperm at different co-incubation lengths. Eighty-four OPU sessions were carried out in 18 cyclic, dry and non-stimulated Holstein Friesian and German black pied cows. Ovum pick up oocytes were matured in vitro for 24 hours and fertilized with frozen-thawed sex sorted or unsorted sperm from the same ejaculate. Fertilization was achieved by two experimental protocols: 1) short gamete co-incubation length: 4, 8 and 12 hours; and 2) long gamete co-incubation length: 18 and 24 hours. After in vitro fertilization, ova were fixed and stained to identify early fertilization events. Sperm penetration, monospermy, pronuclear formation and syngamy did not differ, whether sexed or unsexed sperm was used. Overall, the findings demonstrate similar fertilizing potential between sex-sorted and unsorted sperm.
|
2022-11-25T00:32:02.695Z
|
119,085,045 |
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"DOI": "10.1090/S0002-9939-07-08955-1",
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|
We denote by H the Hilbert space of ordinary Dirichlet series with square-summable coefficients. The main result is that a bounded sequence of points in the half-plane σ > 1/2 is an interpolating sequence for H if and only if it is an interpolating sequence for the Hardy space H 2 of the same half-plane. Similar local results are obtained for Hilbert spaces of ordinary Dirichlet series that relate to Bergman and Dirichlet spaces of the half-plane σ> 1/2.
|
2022-11-29T19:39:41.472Z
|
55,865,815 |
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"DOI": "10.1080/00949650903188452",
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"status": "GREEN",
"url": "https://u-pad.unimc.it/bitstream/11393/37465/1/JSCS2011.pdf"
}
|
Separable processes represent a convenient class of models for data collected on a regular rectangular lattice. Three model-based tests, for testing separability and testing axial symmetry and separability together, are presented. These are shown to be much more powerful than existing model-free tests using the sample periodogram, provided the model assumptions hold. A simulation study also suggests that these tests are not very sensitive to small departures from the assumed process.
|
2022-12-18T04:34:51.720Z
|
237,532,579 |
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"ArXiv": "2109.07678",
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"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.3847/1538-4357/ac3996"
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|
The effects of the ϕ meson on the properties of hyperon stars are studied systematically in the framework of the density-dependent relativistic mean field (DDRMF) model. The ϕ meson shifts the hyperon threshold to a higher density and reduces the hyperon fractions in neutron star cores. It also strongly stiffens the equation of state calculated with various DDRMF effective interactions and increases the maximum mass of hyperon stars, but only a few effective interactions survive under the constraints from recent astrophysical observations. In the DDRMF model, the conformal limit of the sound velocity is still in strong tension with the fact that the maximum mass of neutron stars obtained in theoretical calculations reaches about 2 M ⊙. Based on different interior composition assumptions, we discuss the possibility of the secondary object of GW190814 as a neutron star. When the ϕ meson is considered, DD-ME2 and DD-MEX support the possibility that the secondary object of GW190814 is a hyperon star rapidly rotating with Kepler frequency.
|
2022-12-21T10:59:00.434Z
|
235,097,072 |
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"DOI": "10.1101/2021.05.18.444717",
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"url": "https://www.biorxiv.org/content/biorxiv/early/2021/05/20/2021.05.18.444717.full.pdf"
}
|
The present work provides a logical account for translating ‘caste’ concepts in social insects to an ontology-based data model, which can be used by researchers for describing and organizing entities belonging to non-human societies, as well as for the provision of evidential criteria for evaluating constitutive explanations of ‘social’ entities. We establish the top-level category for the concept of ‘caste’ and give examples on how to accommodate some subcategories (e.g. workers) in the ontology, following a domain granularity framework for the life sciences. We also provide accounts on current limitations in automated reasoning, current practices for ‘caste’ conceptualization, and improvements needed to be addressed in future works
|
2022-09-11T02:05:35.025Z
|
118,177,228 |
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"DOI": "10.1103/PHYSREVC.79.014313",
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"license": null,
"status": null,
"url": null
}
|
Excited states of neutron-rich odd-A and odd-odd Sc isotopes, populated in deep inelastic multinucleon transfer reactions, induced by a {sup 238}U beam on a thin {sup 48}Ca target, have been identified. A strong feeding of both yrast and nonyrast states in such a reaction is illustrated using a combination of a large efficiency spectrometer and a {gamma} detector array. The structure of the populated states is interpreted in terms of the role of the valence proton and neutrons and compared to shell model calculations in the full pf shell.
|
2022-10-24T20:51:34.368Z
|
46,968,473 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/bies.201700132",
"MAG": "2807433166",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc6239423?pdf=render"
}
|
Once dismissed as vestigial organelles, primary cilia have garnered the interest of scientists, given their importance in development/signaling, and for their implication in a new disease category known as ciliopathies. However, many, if not all, “cilia” proteins also have locations/functions outside of the primary cilium. These extraciliary functions can complicate the interpretation of a particular ciliopathy phenotype: it may be a result of defects at the cilium and/or at extraciliary locations, and it could be broadly related to a unifying cellular process for these proteins, such as polarity. Assembly of a cilium has many similarities to the development of other polarized structures. This evolutionarily preserved process for the assembly of polarized cell structures offers a perspective on how the cilium may have evolved. We hypothesize that cilia proteins are critical for cell polarity, and that core polarity proteins may have been specialized to form various cellular protrusions, including primary cilia.
|
2022-11-19T14:49:27.934Z
|
120,893,178 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.4747620",
"MAG": "1989423329",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://www.duo.uio.no/bitstream/10852/39897/1/dravhandling-rekaa-DUO.pdf"
}
|
With reference to laboratory Q-machine studies we analyze the dynamics of a plasma diode under external forcing. Assuming a strong axial magnetic field, the problem is analyzed in one spatial dimension by a particle-in-cell code. The cathode is assumed to be operated in electron rich conditions, supplying an abundance of electrons. We compare different forcing schemes with the results obtained by solving the van der Pol equation. In one method of forcing we apply an oscillation in addition to the DC end plate bias and consider both amplitude and frequency variations. An alternative method of perturbation consists of modelling an absorbing grid at some internal position. Also in this case we can have a constant frequency with varying amplitude or alternatively an oscillation with chirped frequency but constant amplitude. We find that the overall features of the forced van der Pol equation are recovered, but the details in the plasma response need more attention to the harmonic responses, requiring extensio...
|
2022-12-10T09:35:07.511Z
|
129,274,564 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4401/AG-4014",
"MAG": "1504547095",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The ionospheric disturbances observed at many European ionosonde stations in association with the severe geomagnetic storms occurring on 19-20 December 1980 and 11-12 April 1981 were investigated by using the available ionospheric and geomagnetic data. During these storms the ionospheric F region underwent major changes at all mid-latitudes. However, the variations from storm to storm were much larger at lower mid-latitudes. These results support the view that even in assessing the response of the mid-latitude ionosphere to severe geomagnetic storms it is necessary to distinguish carefully between global, regional and local behaviour.
|
2022-02-09T14:51:40.136Z
|
62,335,893 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISCAS.1997.621513",
"MAG": "2167187374",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Power reduction is one of the most important issues of modern VLSI design. Many analyses show that a larger quantity of power is dissipated for the communication, both inside and outside the chip. Different methodologies have been proposed to reduce such power dissipation. In this paper we consider the approach based on reduction of the voltage. In the literature this approach is based on interface circuits that make use of sophisticated technology. Moreover, these circuits are quite complex. Our efforts are devoted to developing a solution based on quite simple interface circuits implemented in conventional CMOS technology. In this paper we review the interface circuits already proposed by the authors and discuss the measurement results of a test chip. Starting from the drawbacks highlighted by these measurements, we propose new circuits based on a new technique of voltage swing reduction and present a preliminary simulation.
|
2022-08-25T03:17:44.057Z
|
237,514,542 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.34172/ijhpm.2021.106",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.ijhpm.com/article_4130_16693a240346646d4ef8d24fc8c721cf.pdf"
}
|
BACKGROUND
Accountability for maternal, newborn and child health (MNCH) is a collaborative endeavour and documenting collaboration dynamics may be key to understanding variations in the performance of MNCH services. This study explored the dynamics of collaboration among frontline health professionals participating in two MNCH coordination structures in a rural South African district. It examined the role and position of actors, the nature of their relationships, and the overall structure of the collaborative network in two sub-districts.
METHODS
Cross-sectional survey using a social network analysis (SNA) methodology of 42 district and sub district actors involved in MNCH coordination structures. Different domains of collaboration (eg, communication, professional support, innovation) were surveyed at key interfaces (district-sub-district, across service delivery levels, and within teams).
RESULTS
The overall network structure reflected a predominantly hierarchical mode of clustering of organisational relationships around hospitals and their referring primary healthcare (PHC) facilities. Clusters were linked through (and dependent on) a combination of district MNCH programme and line managers, identified as central connectors or boundary spanners. Overall network density remained low suggesting potential for strengthening collaborative relationships. Within cluster collaborative patterns (inter-professional and across levels) varied, highlighting the significance of small units in district functioning.
CONCLUSION
SNA provides a mechanism to uncover the nature of relationships and key actors in collaborative dynamics which could point to system strengths and weaknesses. It offers insights on the level of fragmentation within and across small units, and the need to strengthen cohesion and improve collaborative relationships, and ultimately, the delivery of health services.
|
2022-12-12T19:14:57.112Z
|
247,625,971 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1748-0221/17/03/C03036",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An integrated set of neutron diagnostics developed for the deuterium operation of the Large Helical Device (LHD) has been revealing behavior of energetic ions in three-dimensional plasmas, together with energetic-particle diagnostics. In order to obtain deeper understanding of physics related to energetic ions in the LHD, development of plasma diagnostics that can provide energy distribution of energetic ions is now being accelerated. Recent advances in development of the D-D neutron energy spectrometer, a neutral particle analyzer based on a single-crystal chemical vapor deposition diamond, and a tangential fast-ion Dα diagnostic for deuterium discharges of the LHD are described.
|
2022-12-21T05:43:47.503Z
|
57,390,143 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18569/TEMPUS.V5I2.983",
"MAG": "2164411912",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Na obra Health Food Junkie – Overcoming the Obsession with Healthful Eating, o autor Bratman discute a ortorexia nervosa, um transtorno alimentar descrito e batizado por ele em 1997, caracterizado pela obsessao por alimentacao saudavel. Baseado em sua longa experiencia como medico e em sua pratica antiga de se alimentar saudavelmente, no decorrer do livro ele conceitua ortorexia, define a relacao entre o transtorno e a personalidade dos individuos mais comumente afetados, relata os tipos de alimentacao saudavel e os argumentos usados pelos que deles se utilizam, sugere criterios para o diagnostico da ortorexia e algumas abordagens terapeuticas.
|
2022-12-21T19:57:14.320Z
|
110,388,150 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4236/MME.2011.11001",
"MAG": "2042825302",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A mathematical model is developed to assist the design engineers by analyzing the vibration response of non-homogeneous orthotropic rectangular plate under exponentially varying thermal condition. Plate thickness varies parabolically in both directions. Using Rayleigh Ritz approach, frequency parameter and two term deflection function is calculated for diverse values of taper constants. For the best comprehension of the vibration analysis, results are depicted graphically.
|
2022-02-10T05:09:41.567Z
|
115,533,306 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1115/IMECE2018-87640",
"MAG": "2909052581",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The increasing complexity of engineering and technology requires that students master an increasing amount of abstract knowledge to remain competitive in today’s job market. However, today’s students find it difficult to create mental images of abstract concepts, due to lack of real world experience. This problem is more evident in advanced design classes teaching product design concepts and methodologies. In this paper, we introduce a system engineering software package that is used in our capstone design class, with which students are able to create their own framework of product development activities, control information flows, and manage tools and engineering models in each activity. This allows them to plan out and manage their projects using the design methodologies that they learned in class. We assessed student learning in the capstone design class for the last 7 semesters. Independent Samples t-Test and factorial ANOVA are used to analyze the student performance before and after using the software package. We have observed that in the design classes, the system engineering software enables students to practice design methodologies by visualizing and managing product development processes. This helps students not only understand the abstract design methodologies, but also apply the methodologies to their projects and accomplish them more efficiently.
|
2022-08-11T13:41:43.588Z
|
251,799,857 |
{
"externalids": {
"ACL": null,
"ArXiv": "2208.11870",
"DOI": "10.48550/arXiv.2208.11870",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Semi-supervised learning (SSL) promises gains in accuracy compared to training classifiers on small labeled datasets by also training on many unlabeled images. In realistic applica- tions like medical imaging, unlabeled sets will be collected for expediency and thus uncurated : possibly different from the labeled set in represented classes or class frequencies. Un-fortunately, modern deep SSL often makes accuracy worse when given uncurated unlabeled sets. Recent remedies suggest filtering approaches that detect out-of-distribution un- labeled examples and then discard or downweight them. In-stead, we view all unlabeled examples as potentially helpful. We introduce a procedure called Fix-A-Step that can improve heldout accuracy of common deep SSL methods despite lack of curation. The key innovations are augmentations of the labeled set inspired by all unlabeled data and a modification of gradient descent updates to prevent following the multi-task SSL loss from hurting labeled-set accuracy. Though our method is simpler than alternatives, we show consistent accuracy gains on CIFAR-10 and CIFAR-100 benchmarks across all tested levels of artificial contamination for the unlabeled sets. We further suggest a real medical benchmark for SSL: recognizing the view type of ultrasound images of the heart. Our method can learn from 353,500 truly uncurated unlabeled images to deliver gains that generalize across hospitals.
|
2022-08-31T13:23:50.750Z
|
32,594,114 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5603/GP.a2017.0062",
"MAG": "2734574837",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Endometrial carcinoma (EC) is the most common malignancy of the female genital tract encountered in western countries, making it the fourth most common cancer in women. The incidence of uterine cancer is on the rise throughout the developed world where diagnosis is increasingly observed among younger patients. With regard to this, attention has been focused on conducting more studies to achieve a better understanding of the molecular genetics related to endometrial carcinogenesis. Over the years, EC has been classified into two broad histopathological subtypes based on the mechanism of development, and we can therefore observe specific biomarkers related to the respective subtype. Based on this idea, more research has been carried out in the last decade, using biotechnological methods, with the aim to identify new potential tumor markers. By translating these findings into clinical use one may facilitate accurate diagnosis and prognostic prediction, and contribute to individualized treatment. Without a doubt, there is a demanding need to identify biomarkers that can be adopted in clinical practice in order to reduce the time needed to obtain diagnosis. Such markers may be of great value in improving patient outcome. However, a number of problems remain to be solved before this becomes a reality. This paper briefly reviews the current status of rising biomarkers in EC.
|
2022-09-02T18:06:16.166Z
|
252,660,228 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.36632/csi/2022.11.3.19",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.36632/csi/2022.11.3.19"
}
|
The present work aims at examining the capability of ASTER VNIR-SWIR bands to discriminate the granitic rocks and detection of alteration types within them, which could be a possible hosting for U-mineralization in the arid climate. The applied image processing techniques comprising relative band depth, band ratios, minimum noise fraction and color band composites supervised classification as well as two spectral mapping methods (matched filtering and mixture tuned matched filtering) were efficient in the granitic rocks discrimination and alteration end-members (hematite, muscovite, kaolinite and chlorite) identification. These results easily differentiate the mélange matrix into a) metasediments rich in blocks and b) metasediments poor in blocks. Also, the granitic rocks are classified into granodiorite, monzogranite, syenogranite, alkali-feldspar granite and alkaline (riebeckite) granite. The associated abnormal level of radioactivity exhibits 18 ppm and 31 ppm for eU, eTh respectively and mainly restricted to the alkali-feldspar granites, which significantly have higher hematite and muscovite content rather than the other exposures. A detailed geologic map of scale 1:100,000 is constructed from the interpretation of the processed ASTER images, fieldwork and petrographic studies. The results confirmed the ability of ASTER data and recommended it as a rapid and cost-effective tool in geological and mineralogical mapping in arid climate especially when the processing based on a detailed knowledge of the rock mineral assemblages. b) to post-orogenic and differentiation; c) granite and muscovite granite; d) monzogranite;
|
2022-10-07T00:27:16.438Z
|
90,476,065 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17765/2176-9168.2018V11N1P9-30",
"MAG": "2795348436",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Fish culture is perhaps one of segments in animal production with high increasing rates worldwide. However, water quality is a concern due to problems in production and low profits when it is below standard. Current study focuses on water quality based on limnological variables in fish ponds for the rearing of Colossoma macropomum (tambaqui) in sequential supply. Results show that rainfall regimes and management during the production cycle affected the evaluated parameters. Research occurred between August 2013 and July 2014. Further, pH, ammonia and nitrate rates complied with Resolution by CONAMA 357/2005; alkalinity and temperature complied with fish farming standards, contrary to most dissolved oxygen and total phosphorus rates. Electrical conductivity in fish ponds in August 2013, the month with the lowest rainfall indexes in the region, was higher than rates established by CONAMA 357/2005. The density of the phytoplankton community significantly increased in October 2013, with sparse blooming, but featuring low transparency and dissolved oxygen in all fish ponds. Results show the need for systematic introduction of Good Management Practices to improve environmental quality and contribute towards the sustainability of fish farm culture.
|
2022-12-13T11:13:13.022Z
|
90,916,082 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24918/CS.2017.3",
"MAG": "2608756853",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Metagenomics is rapidly evolving due to advances in sequencing technologies and bioinformatics, but without proper training to interpret these datasets, student understanding remains limited. Aimed at undergraduate juniors and seniors and graduate students, our eight-week metagenomics course introduces students to different approaches for producing and analyzing metagenomics data to test hypotheses. Here we present our approach for introducing students to the powerful command-line-based sequence analysis pipeline: Quantitative Insights into Microbial Ecology (QIIME, pronounced “chime”). Used extensively in metagenomics research, QIIME performs quality control analysis of raw data from highthroughput sequencers, clusters the data by taxonomic relatedness, and produces a data table of taxonomy by sample. This data table can be further analyzed with QIIME, or used in statistical analysis programs such as R or Primer. In our lesson, students first familiarize themselves with the format of QIIME commands with a worksheet that deconstructs a command to help students understand the input, output, and arguments. Our students have the most trouble with getting a functional version of QIIME running without error, so we have created instructional videos for the setup and running of basic QIIME commands. During one lab period, we lead the class through processing of a sample subset to identify issues and discuss limitations of this approach. Finally, student pairs analyze their own samples and present their findings to the class. This process builds student confidence in their ability to analyze high-throughput sequencing results of metagenomic datasets with the open-source QIIME pipeline. Citation: Stevens, J.L., DeHority, R., and Goller, C.C. 2017. Using QIIME to Interpret Environmental Microbial Communities in an Upper Level Metagenomics Course. CourseSource. https://doi.org/10.24918/cs.2017.3 Editor: Kristin Fox, Union College, Schenectady, NY Received: 06/15/2016; Accepted: 11/28/2017; Published: 03/28/2017 Copyright: © 2017 Stevens, DeHority, and Goller. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercialShareAlike 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. This manuscript presents original worksheets, videos and information to which authors own the rights. Conflict of Interest and Funding Statement: The North Carolina State University Biotechnology Program provided the resources to offer the course in which this lesson was utilized. None of the authors have a financial, personal, or professional conflict of interest related to this work. Supporting Materials: S1. QIIME activity: Assignment 1 Worksheet, S2. QIIME activity: Assignment 2 Worksheet and key, S3. QIIME activity: Pair presentation grading rubric, S4. QIIME activity. List of tutorial videos and links, S5. QIIME activity: Compressed file with raw data, long step output files, annotated pipeline (link to files), S6. QIIME activity: Worksheet/handout with Helpful basic commands presentation, and S7. QIIME activity: Glossary of commonly used terms in this lesson. *Correspondence to: Jordan Hall 6102, Campus Box 7512, 2800 Faucette Drive, Raleigh, NC 27695. Fax: 919-513-4231. Phone: 919-513-4135 Email: ccgoller@ncsu.edu CourseSource | www.coursesource.org 2017 | Volume 04 1 Lesson
|
2022-12-19T05:04:10.094Z
|
104,015,882 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15561/18189172.2017.0404",
"MAG": "2655638636",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.sportpedagogy.org.ua/index.php/PPS/article/download/766/636"
}
|
Purpose Regular training improves maximal oxygen consumption (VO2max) and cardiovascular function. The aim of this study was to determine the central hemodynamic adaptation after interval aerobic jogging in healthy male students. Methods Twenty untrained male students (aged 18-20 years) were volunteered and randomly divided into two groups: interval (I; n=10) and control (C; n=10). Countryside interval jogging programme 5×9 min at 70% of Maximum Heart Rate interspersed with 4 min inactive recovery, 3 days/week for 8-weeks performed. The control group remained sedentary during the period. VO2max obtained using the step-test. Standard medical method of tetrapolar chest reography (impedance cardiography) was performed for hemodynamic parameters, during resting and after workload (Step-test) conditions, before and after the training. Results Using t-test, after eight weeks the resting heart rate in both groups did not change significantly (P>0.05). The stroke volume increased significantly in I group after workload (P≤0.05). The cardiac output (CO) did not change significantly in both groups (P>0.05). The systolic blood pressure in I group decreased significantly at rest and after workload (P≤0.05). The diastolic blood pressure did not change significantly in both groups (P>0.05). The systemic vascular resistance in the both groups did not change significantly (P>0.05). The maximal aerobic capacity absolute and relative increased significantly in I group (P≤0.05). Significant difference between groups in stroke volume, cardiac output, VO2max absolute and relative (P≤0.05) was found. Conclusions. Eight weeks aerobic interval jogging can influence on central hemodynamic and VO2max in male students.
|
2022-12-21T10:18:08.196Z
|
254,494,261 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/20499361221135128",
"MAG": null,
"PubMedCentral": "9742716"
},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742716"
}
|
Introduction: Despite the prolongation of hospitalization, increase in morbidity, mortality and cost of care associated with both surgical site infections (SSIs) and antibiotic resistance, there are limited data on SSIs and antibiotic resistance to guide prevention strategies in Sierra Leone. Methods: This study assessed the burden of SSIs and related antibiotic resistance in the 34 Military Hospital (MH) and Makeni Government Hospital (MGH) located in two geographic regions of Sierra Leone using a prospective study design to collect data from adults aged 18 years or older. Results: Of the 417 patients, 233 (55.9%) were enrolled in MGH. Most were women 294 (70.5%). The incidence rate of SSI was 5.5 per 1000 patient-days, and the cumulative incidence of SSI was 8.2%. Common bacteria isolated in MH were Escherichia coli (6,33.3%) and Pseudomonas aeruginosa (3,16.7%) and in MGH were P. aeruginosa (3,42.9%) and Proteus mirabilis (2,28.9%). Of the gram-negative bacteria, 40% were Extended-spectrum beta-lactamase-producing Enterobacteriaceae, 33% were Carbapenem-resistant P. aeruginosa and 10% were carbapenem-resistant Enterobacteriaceae. Conclusion: Although the incidence of SSIs in our study is lower than previously reported, the rate of antibiotic resistance reported in this study is high. Urgent action is needed to invest in the microbiology infrastructure to support SSI surveillance and prevention strategies.
|
2022-12-29T18:20:17.689Z
|
87,187,767 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.2307/2423351",
"MAG": "2319098944",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Osteometric variation of 12 bones in the high-speed wing of the Mexican free-tailed bat, Tadarida brasiliensis, was analyzed and found to be closely comparable to variation in the high-lift wing of Myotis. Coefficients of variation and correlation were obtained. We found high variation in phalanx one, digit II, and a marked increase of variation distally. Generally, we found coefficients of variation to fall between two and eight. Compared to Myotis, Tadarida has higher variation in phalanx two, digit V, and lower variation in the distal elements of digit III (emphasizing a probable functional significance of the wing tip). Overall variation is lower in Tadarida. There is strong correlation among distal bones of the third and fifth digits (important aerodynamically) and the humerus and radius in Tadarida. Similar bones often showed strong correlation. No marked preponderance of advanced characters was noted in either genus if specializations for maneuverable flight are given equal weight with those of rapid flight, and we question that Molossidae should be considered moreadvanced than Vespertilionidae. INTRODUCTION Structure and form of an organism are related to function, hence, obviously, to exploitation of an ecological niche. For example, in birds the form of the wing is related to mode of flight (Savile, 1957:212). Generally, the amount of variation of a structure in a population sample is apparently also related to function, in that variation is more extensive in nonfunctional or vestigial structures (Simpson, 1953; Bader and Hall, 1960:15). We attempt to analyze osteometric variation in the high-speed wing of the Mexican free-tailed bat, Tadarida brasiliensis, which ostensibly is capable of rapid and enduring flight (Vaughan, 1959, 1966; and others), in order to compare the nature and extent of this variation with that described by Bader and Hall (1960) for two species of Myotis, of slower, more maneuverable and probably less enduring flight. Comments are presented concerning some adaptations to flight of Myotis (Vespertilionidae) and Tadarida (Molossidae), although the primary aim is to obtain verification of the work by Bader and Hall (1960). Acknowledgments.-We are grateful to Mr. John Lynch and Mr. Macreay Landy for the bats collected by them in Veracruz, Mexico, and to Professor Hobart M. Smith for the loan of his comparator. We are especially indebted to Mr. James T. Wallace for his assistance in programming our problem for computer use at the University of Illinois Digital Computer Laboratory. MATERIALS AND METHODS Fifty bats utilized were obtained 26-28 July 1964 from a cave at Cofre de Perote, 2800 m elevation, Veracruz, Mexico, where all
|
2022-02-10T21:42:46.804Z
|
71,486,044 |
{
"externalids": {
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"DOI": "10.1001/JAMA.1965.03080140069025",
"MAG": "1998009567",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To the Editor:— Would you like to have a secretary who— Thinks like a man, Acts like a lady, Looks like a model, But works like a dog? This anonymous motto has been adopted by the Medical Typists' Course, a program designed to give physicians better-trained medical secretaries. The lengthy transitional period from general secretary to qualified medical secretary is unfair to both employer and employee. Let's do something about it! This problem is with us for a very good reason: Who is training the medical secretary? Almost no one. People within the medical profession are too busy to lend a hand here; people outside the medical profession don't know how. The responsibility actually lies with business teachers, but very few want to attempt material for which they themselves had no training. On May 15 an educational forum on "Teaching the Medical Typists' Course" will be held at the Medical
|
2022-02-11T10:42:26.849Z
|
52,881,390 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/jmor.1051500403",
"MAG": "2038904083",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The arrangement of collagen fibers over the body surface in the basement lamella of Pseudaeris and Xenopus tadpoles is described. It can be viewed by scanning microscopy after removal of epidermis and basal lamina by trypsin treatment of alcohol fixed tissue. The orthogonal array is modified in regions where fiber direction changes extensively such as the base of the ventral fin or the posterior part of the head. In these regions “exceptional points” in the orthogonal pattern occur, as described by Rosin (1946). The pattern is bilaterally symmetrical. In the region of the nasal opening the orthogonal pattern is replaced by a mat of randomly oriented fibers. In tail regeneration the wound area is marked by aberrant disposition of collagen anteriorly then a mat of randomly disposed fibers followed posteriorly with a sharp transition to the orthogonal pattern of the regenerate. No fiber terminations could be seen in normal or regenerating regions of the lamella.
|
2022-09-01T08:10:05.721Z
|
38,874,720 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1046/J.1439-0442.2002.00433.X",
"MAG": "2034712731",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
One of the major goals of this study was to establish fast, reliable and sensitive assays for the quality control of immunomodulating phytopreparations and to determine whether pharmacological compounds or phytopreparations have effects on bovine immune cells. Flow cytometric methods were chosen because they are very sensitive in the detection of even subtle effects on cells. In this study, we addressed the question of whether these methods are useful in monitoring the effects of EquiMun and its compounds on bovine leucocytes in vitro. EquiMun is a fixed combination of Echinacea purpurea (Ec), Thuja occidentalis (Th) and elemental phosphorus (Ph) in different starting concentrations. Separated blood mononuclear cells (MNC) and polymorphonuclear cells (PMN, mainly neutrophils) were cultured for up to 44 h in vitro in the presence or absence of the tested substances. Whereas MNC were not affected by any of the compounds, EquiMun, Ec, Th and Ph significantly reduced the forward scatter (size) of cultured PMN without affecting their side scatter (granularity). The size effects were paralleled by a significantly enhanced viability of PMN after 20 h in culture. The observed effects were constant over wide concentration ranges and indicate a very similar reaction of leucocytes from individual cows. Whereas spontaneous generation of reactive oxygen species (ROS) by neutrophils was up-regulated by Ph and EquiMun, EquiMun down-regulated the phorbol ester-stimulated ROS production. However, ROS generation by neutrophils displayed a large inter-individual variation with less apparent, down-regulatory effects of EquiMun. The ability of PMN to kill target cells via antibody-independent cellular cytotoxicity showed small inter-individual variations and was enhanced by Ec and Th but not by Ph and EquiMun, probably due to dose-dependent effects. In summary, the flow cytometric characterization of cellular viability and shape changes of neutrophils seem to be a suitable and reliable approach for the quality test of immunomodulating phytomedicines based on bioassays.
|
2022-09-14T04:01:13.049Z
|
123,455,714 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1137/S5089547989529577",
"MAG": "2069057327",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Let $H$ be positive definite, let $\Delta H$ be Hermitian, and suppose that $\|H^{-1/2} (\Delta H) H^{-1/2} \| \\ =1$. It is shown that the least constant $c_n$ such that \[ || (H + \eta \Delta H)^{1/2}H^{-1/2} - I || \leq c_n \eta + 0(\eta^2) \] for all $n \times n$ $H$ and $\Delta H$ grows like $\log n$. This fact has consequences in eigenvector perturbation theory.
|
2022-09-24T08:31:01.485Z
|
247,783,316 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fpubh.2022.863522",
"MAG": null,
"PubMedCentral": "9001955"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fpubh.2022.863522/pdf"
}
|
Influenza shares the same putative transmission pathway with coronavirus disease 2019 (COVID-19), and causes tremendous morbidity and mortality annually globally. Since the transmission of COVID-19 in China, a series of non-pharmaceutical interventions (NPIs) against to the disease have been implemented to contain its transmission. Based on the surveillance data of influenza, Search Engine Index, and meteorological factors from 2011 to 2021 in Xi'an, and the different level of emergence responses for COVID-19 from 2020 to 2021, Bayesian Structural Time Series model and interrupted time series analysis were applied to quantitatively assess the impact of NPIs in sequent phases with different intensities, and to estimate the reduction of influenza infections. From 2011 to 2021, a total of 197,528 confirmed cases of influenza were reported in Xi'an, and the incidence of influenza continuously increased from 2011 to 2019, especially, in 2019–2020, when the incidence was up to 975.90 per 100,000 persons; however, it showed a sharp reduction of 97.68% in 2020–2021, and of 87.22% in 2021, comparing with 2019–2020. The highest impact on reduction of influenza was observed in the phase of strict implementation of NPIs with an inclusion probability of 0.54. The weekly influenza incidence was reduced by 95.45%, and an approximate reduction of 210,100 (95% CI: 125,100–329,500) influenza infections was found during the post-COVID-19 period. The reduction exhibited significant variations in the geographical, population, and temporal distribution. Our findings demonstrated that NPIs against COVID-19 had a long-term impact on the reduction of influenza transmission.
|
2022-12-31T06:12:57.502Z
|
123,455,359 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0022-3735/1/3/421",
"MAG": "2094754463",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Potassium-antimony-caesium photocathodes having integral sensitivities to tungsten light of 50-75 μA lm−1 may be prepared by evaporating an additional antimony layer on top of a potassium antimonide photocathode and admitting caesium at 150°C.
|
2022-02-09T18:43:23.144Z
|
58,471,206 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/CJE.2016.08.005",
"MAG": "2577262449",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Similar time series searching plays an important role in applications such as time series classification and outlier detection. We observe that different segment of a time series may have different significance, thus propose to assign different weight to each segment, and extract those segments with highest weights for distance computation. Since these segments are more representative, we can achieve high accuracy of similarity search with much lower computation overhead. The result of experiments on both real world and synthetic data sets demonstrates that we can achieve comparable or even higher accuracy while largely reduce the computation overhead, if we use only those important segments rather than the whole time series while performing similarity search.
|
2022-02-11T17:26:46.473Z
|
61,663,632 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/PBMT024E_CH11",
"MAG": "2234797447",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Any written business document must stand up to analysis, and its only real test is whether its reader finds it does the job it was intended to do. This means it must have a clear purpose, and that what it says, and how it says it, are understandable; indeed, that it exhibits any other characteristic that it needs to meet its specific intention and such as has been set out in the last chapter. This chapter looks at the approach necessary for different types of document It should be noted at once that there is no one right way to write anything. A variety of word combinations and of style can be appropriate, but there are some things that must be done in particular ways and there are certainly things to avoid.
|
2022-02-11T15:34:35.330Z
|
28,388,483 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/vr.g2249",
"MAG": "2058047662",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In 2013, to celebrate its 125th anniversary, Veterinary Record published a series of articles exploring developments in veterinary medicine since the journal was launched. According to an online poll in which over 1000 readers voted, the most important innovation in that time was anaesthesia and analgesia. Here, Polly Taylor explains why advancements in this field have made such a crucial impact on animal health and welfare and clinical practice. Veterinary anaesthesia and analgesia: from chloroform to designer drugs
|
2022-02-27T09:57:17.787Z
|
15,818,325 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fpsyg.2016.00691",
"MAG": "2350025496",
"PubMedCentral": "4864537"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fpsyg.2016.00691/pdf"
}
|
Previous research showed that a values-affirmation intervention can help reduce the achievement gap between African American and European American students in the US. In the present study, it was examined if these results would generalize to ethnic minority students in a country outside the US, namely the Netherlands, where there is also an achievement gap between native and ethnic minority students. This type of intervention was tested in two separate studies, the first among first-year pre-vocational students (n = 361, 84% ethnic minority), and the second among sixth grade students (n = 290, 96% ethnic minority). Most minority participants had a Turkish-Dutch or Moroccan-Dutch immigrant background. In the second study, a third condition was added to the original paradigm, in which students elaborated on either their affirmation- or a control exercise with the help of a teaching assistant. We also examined whether values affirmation affected the level of problem behavior of negatively stereotyped ethnic minority youth. Contrary to what was expected, multilevel analyses revealed that the intervention had no effect on the school achievement or the problem behavior of the ethnic minority students. Possible explanations for these findings, mainly related to contextual and cultural differences between the Netherlands and the US, are discussed.
|
2022-12-21T20:00:36.133Z
|
212,664,384 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/nu12030703",
"MAG": "3009311242",
"PubMedCentral": "7146357"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2072-6643/12/3/703/pdf?version=1585217060"
}
|
Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer’s disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied the association between dietary quality and cognitive impairment in Alzheimer’s disease (AD) dementia, mild cognitive impairment (MCI) and controls. We included 357 participants from the NUDAD project (134 AD dementia, 90 MCI, 133 controls). We assessed adherence to dietary guidelines (components: vegetables, fruit, fibers, fish, saturated fat, trans-fat, salt, and alcohol), and cognitive performance (domains: memory, language, visuospatial functioning, attention, and executive functioning). In the total population, linear regression analyses showed a lower vegetable intake is associated with poorer global cognition, visuospatial functioning, attention and executive functioning. In AD dementia, lower total adherence to dietary guidelines and higher alcohol intake were associated with poorer memory, a lower vegetable intake with poorer global cognition and executive functioning, and a higher trans-fat intake with poorer executive functioning. In conclusion, a suboptimal diet is associated with more severely impaired cognition—this association is mostly attributable to a lower vegetable intake and is most pronounced in AD dementia.
|
2022-12-25T22:58:32.790Z
|
220,440,671 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/002083451606600104",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
After Germany's anti-Semitic past, current attitudes towards refugees and immigrants are surveyed and compared with other countries. Frequent xenophobia in former East Germany, despite fewer foreigners than in West Germany, is explained by official denial of fascist legacy, in contrast to Western re-education policy of Nazism. Islamophobia and allegations of welfare tourism are a xenophobic obsession. Yet, overall attitudes towards outsiders have improved with legislative changes in immigration policy and citizenship acquisition — anti-Muslim demonstrations by PEGIDA in Dresden and arson attacks on asylum homes notwithstanding. Younger, better-educated Germans are far less xenophobic. This analysis of German public discourse provides relevant statistics on immigration, explores contested integration/asylum policies, scrutinizes implications of categories from the cultural repertoire through which migrancy is understood and assesses the contending political forces. [R, abr.]
|
2022-07-01T04:39:46.151Z
|
251,264,001 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/app12157681",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2076-3417/12/15/7681/pdf?version=1660025611"
}
|
Web applications widely use the logging functionality, but improper handling can bring serious security threats. An attacker can trigger the execution of malicious data by writing malicious data to the web application logs and then accessing the view–logs interface, resulting in a vulnerability of the web application log injection. However, detecting this type of vulnerability requires automatic discovery of log-injectable interfaces and view–logs interfaces, which is difficult. In addition, bypasssing the application-specific input-filtering checks to write an effective payload to the log is also challenging. This paper proposes LogInjector, an efficient web application log injection vulnerability detection method. First, it obtains the log storage form and location and then finds the log-injectable interfaces through the extended dynamic crawler. Second, it automatically identifies the web application view–logs interfaces. Finally, LogInjector utilizes a dynamic testing approach based on the feedback-guided mutation to detect web application log injection vulnerabilities. To verify the effectiveness of LogInjector, we test it in 14 popular web applications in real-world cases and compare it with Black Widow, the state-of-the-art web vulnerability scanner. LogInjector detects 16 web application log injection vulnerabilities, including 6 zero-day vulnerabilities, while Black Widow can only detect three log injection vulnerabilities, demonstrating the effectiveness of LogInjector in practice.
|
2022-08-20T11:16:59.405Z
|
109,837,544 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7232/IEIF.2011.24.1.001",
"MAG": "1973005170",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The purpose of this research was to develop an integrated interface for the usability test of systems or products in the design process. It is capable of automatically creating GOMS models which can predict human task performances. It can generate GOMS models to be interacted with the prototype interfaces. It can also effectively manage various design information and various usability test results to be implemented into the new product and/or system design. Thus we can perform usability test for products or system prototypes more effectively and also reduce time and effort required for this test. For usability tests, we established an integrated interface based on GOMS model by the LabVIEW program. We constructed the system that the linkage to GOMS model is available. Using this integrated interface, the menu structure of mobile phone can be constructed easily. User can design a depth and a breath that he want. The size of button and the label of the button is changable. The path to the goal can be defined by the user. Using a designed menu structure, the experiment could be performed. The results of GOMS model and the actual time are presented. Besides, values of operators of GOMS model can be defined as the value that user wants. Using the integrated interface that we developed, the optimal menu structure deducted. The menu structure that user wants can be established easily. The optimal layout and button size can be decided by comparison of numerous menu structures. User can choose the method of usability test among GOMS model and empirical data. Using this integrated interface, the time and costs can be saved and the optimal menu structure can be found easily.
|
2022-08-29T04:24:50.907Z
|
122,663,883 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.125068",
"MAG": "2071226753",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This letter reports on the use of nonselective dry and selective wet etching to fabricate a gallium arsenide (GaAs) based three-dimensional infrared photonic crystal with a simple-cubic lattice structure. A two-and-one-half-period photonic crystal fabricated using this procedure demonstrated a drop in transmission of approximately 10 dB at a center wavelength of 12 μm for normally incident angles. A shift in the long-wavelength shoulder from 16 to 15 μm was observed as the incident infrared beam was varied from normal to oblique incidence. The measured drop in transmission agrees well with the band gap predicted theoretically for this simple-cubic structure.
|
2022-09-13T17:56:04.329Z
|
29,338,302 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1365-2141.2005.05578.x",
"MAG": "2077127085",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.2005.05578.x"
}
|
Several lines of evidence indicate the clonal nature of juvenile myelomonocytic leukaemia (JMML), involving myeloid, erythroid, megakaryocyte and B‐lymphoid lineages. However, it is unclear whether the T‐lymphocyte lineage is involved. We demonstrated that cells from six patients with JMML repopulated in non‐obese diabetic/severe combined immunodeficient/γcnull mice and differentiated into granulocytes, monocytes, erythrocytes, B lymphocytes, T lymphocytes and natural killer cells. The percentage of human CD45 antigen‐positive cells ranged from 41% to 73% in the murine bone marrow 12 weeks after transplantation. To examine the involvement of lymphocyte subpopulations, we purified human CD3+, CD19+ and CD56+ cells from murine bone marrow cells transplanted from a patient with monosomy 7. Fluorescence in situ hybridization (FISH) showed the clonal marker in 96–100% of purified CD3+, CD19+ and CD56+ subpopulations. These findings support the concept that JMML originates in transplantable multilineage haematopoietic stem cells. This novel murine xenotransplant model should be useful for investigating the nature of stem cells and testing new therapies for patients with JMML.
|
2022-12-08T16:27:14.502Z
|
113,077,328 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00207543.2015.1107195",
"MAG": "2285636263",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
At any distribution centre (DC), the decision of whether to synchronise inbound and outbound flows for cross-docking, or to decouple these flows by maintaining inventory, has a significant impact on supply chain performance. Key drivers of this decision, in turn, are the sizes of the discrete lots that comprise the flows. Thus, we formulate an original optimisation model that determines order lot-sizing decisions to minimise, for given constant arc flows, the sum of ordering cost and pipeline inventory cost on arcs and buffer inventory at DCs. The model employs an average throughput as a surrogate to estimate buffer inventory at facilities at which synchronisation is not economical and therefore serves to decouple inbound and outbound flows. Perfect lot-for-lot matching of shipments would impose very restrictive constraints on supply chain operations, but equality of average throughput indicates an innovative, relaxed mode of synchronisation. This mode is practicable for cross-docking by means of bulk-breaking or consolidation of shipments. A heuristic approach based on the Lagrangian relaxation and subgradient optimisation is developed for the non-linear mixed-general integer optimisation model, which is illustrated by numerical examples and tested using a benchmark data set.
|
2022-12-17T11:08:45.785Z
|
204,154,758 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/acv.12539",
"MAG": "2976243607",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "HYBRID",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acv.12539"
}
|
Large‐scale climatic processes such as the El Niño‐Southern Oscillation (ENSO) can have severe effects on the survival of seabirds in their breeding regions. However, there is a fundamental lack of understanding about how environmental factors are related to the mortality of these organisms in non‐breeding areas of the tropics. We investigate here the direct and indirect effects of ENSO and oceanographic variables on the mortality of three migratory seabird species targeted by conservation programmes focused on human impacts: the Atlantic yellow‐nosed albatross Thalassarche chlororhynchos, the Magellanic penguin Spheniscus magellanicus and the Manx shearwater Puffinus puffinus in a non‐breeding area in Brazil, tropical Atlantic. We find that the intensification of ENSO increases the mortality of Manx shearwaters by enhancing the local storm activity. The mortality of Atlantic yellow‐nosed albatrosses and Magellanic penguins is also related to a local increase in storm activity but regardless of the ENSO signature. Increased mortality of Magellanic penguins is observed when biological productivity falls below the annual average (1.7 mg m−3). Adverse climatic conditions are highly deleterious for migratory seabirds and single storm episodes can cause massive deaths, thus exacerbating population declines. We argue that conservation and management strategies for migratory seabirds studied here should not only focus on direct human impacts but should also consider mitigating the effects of climate variability.
|
2022-12-24T17:18:07.311Z
|
226,405,153 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5194/egusphere-egu2020-20396",
"MAG": "3094352016",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
<p><span>Transparency in Hamburg's scientific community, the further development of Hamburg as a university location, open access to research results, and secure long-term data storage are the main objectives of the Hamburg Open Science program. Hamburg Open Science bundles eight inter-university projects to promote open science at Hamburg's six state universities, the University Medical Center Hamburg Eppendorf and the Hamburg Carl von Ossietzky State and University Library.<br><br></span><span>The program is funded by the city of Hamburg for the period 2018-2020 and is supported by the Ministry of Science, Research and Equality. The eight projects science data management, science information system, open access repositories, archive data storage, modern publishing, web platform, 3D and audio visual science data, and the digital cultural change are developing the basis for the long-term operation of Open Science services from 2021 onwards. The web platform www.openscience.hamburg.de provides access to research results from Hamburg and is to be expanded into an information platform on science in Hamburg.<br><br></span><span>The idea of Open Science in the program context is that the digitalization of science enables a complete redesign of basic science principles and turning them into reality under the principles of transparency, reproducibility, reusability, open communication and exchange. <br><br></span><span>Therefore, the project aims of the <strong>digital cultural change</strong> are to create an awareness of open science among researchers and to integrate openness into their everyday work so that they can continue to focus on their research. The Hamburg Open Science program thus supports all orientations of Open Science by actively supporting scientists in their working methods, structures and behavior patterns towards open science.</span></p>
|
2022-02-07T23:54:34.152Z
|
122,283,490 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0031-8949/37/2/007",
"MAG": "2047093543",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The interface contributions to the total density of states, which determine the temperature dependence of the interface specific heat, are very simply obtained by a direct application of the surface Green function matching analysis to two inviscid and compressible liquids. It is shown that the main contribution is due to capillarity effects, giving a T4/3 behaviour, whereas the next contribution coming from both capillarity and compressibility effects is responsible for a T2 behaviour. A numerical estimate for several media is made and it is found that it would be extremely difficult to determine experimentally the very small interface vibrational contribution to the low temperature specific heat, in the case of liquids.
|
2022-02-09T19:18:26.433Z
|
18,331,659 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICIII.2010.176",
"MAG": "2107618490",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
It is much more important for manufacturing products to accurately and quickly recognizing/monitoring quality problems in a complex manufacturing process. Back Propagation Neural Network (BPNN) is receiving increased attention in the process monitoring because of their universal function approximate. In this study, Cascade Correlation Neural Network and Back Propagation Neural Network simultaneously have been trained to monitoring faulty quality categories of the products being produced in manufacturing process. Two examples were used here for analysis. Promising results were received according to accuracy using both Neural Network models but it was concluded that the Neural Network Model based on Cascade Correlation algorithm performed better in comparison with the Neural Network Model based on Back Propagation algorithm.
|
2022-02-12T23:47:10.960Z
|
96,393,875 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00397910500384921",
"MAG": "2018171686",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract A phtalimido group can be readily introduced at the 5″‐position of N‐Boc ribostamycin 6 under Mitsunobu reaction conditions. However, in the case of N‐Boc neomycin B 4 a competitive bicyclization process occurred within the ring IV of the antibiotic, which led to compound 8, whose structure was fully elucidated by NMR spectroscopic methods. Accordingly, particular care must be exercised to achieve this chemical modification of the four‐ring antibiotic.
|
2022-09-01T05:02:11.184Z
|
145,059,716 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/13803610902955630",
"MAG": "2087467890",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents findings from research exploring gender by item difficulty interaction on mathematics test scores in Cyprus. Data steamed from 2 longitudinal studies with 4 different age groups of primary school students. The hypothesis that boys tended to outperform girls on the hardest items and girls tended to outperform boys on the easiest items was generally supported for each year group. The effect of social class was also examined. For each social class, there was a correlation between the item difficulty differences estimated on girls and boys separately and the difficulty of the item estimated on the whole sample. It is claimed that in understanding gender differences in mathematics, item difficulty should be treated as an independent variable. Suggestions for further studies are provided, and implications for the development of assessment policy in mathematics are drawn.
|
2022-09-09T12:09:14.723Z
|
199,311,296 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7153/JCA-2019-14-01",
"MAG": "2957704548",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
. With the help of weighted sharing of values, we investigate the uniqueness of rational function of a meromorphic functions sharing a small function with its differential polynomial. Our results will extend and improve a number of result in the direction of Yu [18]. Speci fi cally we stress on the improvement of two recent results of Charak and Lal [8] and Li, Yang and Liu [14]. We have exhibited several examples to justify our certain claims.
|
2022-09-10T19:10:43.214Z
|
14,899,916 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICIN.2009.5357061",
"MAG": "2129243442",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Users want to access user generated content and recommendations in a contextualized way while on the move. In this paper we illustrate the POI radar service and its architecture, a mobile mashup of integrated location, social network and users' recommendations to provide contextualized notifications of nearby points of interest voted by user's contacts. A description of the service scenario, architecture and its technical components is given, focusing on how information is mashed up with mobile technologies.
|
2022-10-06T16:06:28.986Z
|
78,318,048 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17219/PZP/62044",
"MAG": "2499887455",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background. Cancer of the larynx is a serious health issue. One method to treat it is laryngectomy, which causes mutilation and serious changes in the patient’s everyday life (loss of voice, difficulty in swallowing, pain associated with surgery, radiotherapy and chemotherapy, changes in the respiratory tracts, reducing the professional and social activity). The functioning and the activity of the patient have a significant impact on the quality of their life and recovery. Objectives. To present the quality of life of patients after laryngectomy surgery. Material and Methods. The research was conducted from December 2013 to April 2014 in three wards in Wroclaw and on patients belonging to the Polish Society of Laryngectomees. The research involved 80 patients (60 men and Piel. Zdr. Publ. 2016, 6, 2, 127–136 DOI: 10.17219/pzp/62044 PRACE ORYGINALNE © Copyright by Wroclaw Medical University ISSN 2082-9876 J.M. Juzwiszyn et al. 128 Mimo ciągłego udoskonalania diagnostyki oraz metod leczenia chirurgicznego i uzupełniającego rak krtani jest nadal dużym zagrożeniem dla zdrowia i życia chorego [2]. Rak krtani to najczęściej występujący nowotwór złośliwy w obrębie głowy i szyi. Ze względu na swoją specyfikę nadal stanowi poważny problem onkologiczny [9]. Każdego roku na całym świecie zgłasza się ponad 100 tys. nowych przypadków raka krtani, co stanowi mniej niż 1% wszystkich nowotworów. W porównaniu z innymi formami nowotworów rokowanie jest zazwyczaj korzystne, gdyż krtań jest bardzo wrażliwa i jakakolwiek zmiana, nawet niewielka (np. rosnący guz), często jest od razu słyszalna lub wyczuwalna. Umożliwia to zatem wczesne wykrycie i podjęcie leczenia [3]. W Polsce każdego roku około 2000 chorych jest poddawanych operacji całkowitego usunięcia krtani [4]. Według danych NFZ w 2004 r. wykonano w Polsce 1580 operacji usunięcia krtani [1]. Rak krtani jest schorzeniem, które występuje zdecydowanie częściej u mężczyzn niż u kobiet [9], głównie u pacjentów w 5. i 6. dekadzie życia, choć granica ta przesuwa się w stronę młodszych chorych. W Polsce jest 7. rodzajem nowotworu przyczyniającym się do śmierci – po raku płuc, żołądka, prostaty, trzustki, pęcherza moczowego i jelita grubego [12]. Zwiększenie liczby zachorowań na nowotwory złośliwe w naszym kraju jest spowodowane m.in.: przyrostem liczby ludności, starzeniem się populacji, zwiększeniem liczby czynników rakotwórczych oraz zachowań sprzyjających rozwojowi nowotworów, takich jak palenie tytoniu czy nadużywanie napojów alkoholowych [4]. W zależności od stadium, w jakim wykryto raka krtani, w leczeniu stosuje się radioterapię, chemioterapię, zabieg chirurgiczny lub połączenie tych 3 metod. Jeżeli guz jest zbyt duży lub nawraca po radiolub chemioterapii, zwykle usuwa się go chirurgicznie. Tego rodzaju operacja jest najczęściej wykonywana przez laryngologa i często skutkuje całkowitym usunięciem krtani. Pacjent będący po takim zabiegu chirurgicznym jest określany jako osoba laryngektomowana [14]. Całkowite usunięcie krtani wywołuje wiele bardzo niekorzystnych zmian dla całego organizmu człowieka, ponieważ uderza bezpośrednio w najbardziej podstawowe funkcje, jak komunikacja werbalna, oddychanie czy relacje społeczne. Zostaje utracona czynność górnych dróg oddechowych, do których należy oczyszczanie, nawilżanie i ogrzewanie powietrza. Następuje utrata węchu i odruchów nosowych [7]. Celem pracy była analiza wybranych determinantów, takich jak: wiek, płeć, poziom wykształcenia i sytuacja socjoekonomiczna, problemy z mową, wsparcie bliskich, samoakceptacja, oraz ich wpływu na poziom jakości życia osób po laryngektomii.
|
2022-02-11T04:51:41.571Z
|
35,929,332 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1109/ISEMC.2015.7256386",
"MAG": "1562891229",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Electromagnetic Compatibility Conference Japan announced in August, 2014 its reforms to the 1997 “Guidelines for use of mobile phones and other devices in hospitals.” The guidelines were amended because the medical electromagnetic environment has changed dramatically with the termination of second-generation cell phone service and the spread of wireless LAN, etc. Programs for the improvement of patient service and the operating efficiency of hospitals through the use of wireless communications have become the norm. Compared with the former guidelines, the hospital areas in which mobile phones can be used have been extended, with the condition that at least 1m be kept from a medical device. Also, the guidelines newly require the appropriate management of wireless communications and the electromagnetic environment. Our specialized research has led to these amendments. Here we explain the content and basis of the new guidelines.
|
2022-12-11T07:35:44.668Z
|
220,775,730 |
{
"externalids": {
"ACL": null,
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"DOI": "10.1177/097152319500200209",
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"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
1. The Prime Minister of the People’s Republic of Bangladesh, Her Excellency Begum Khaleda Zia, the King of Bhutan, His Majesty Jigme Singye Wangchuck, the Prime Minister of the Republic of India, His Excellency Mr. P.V. Narasimha Rao, the President of the Republic of Maldives, His Excellency Mr. Maumoon Abdul Gayoom, the Prime Minister of Nepal, the Rt. Hon. Manmohan Adhikari, the President of the Islamic Republic of Pakistan, His Excellency Mr. Farooq Ahmad Khan Leghari and the President of the Democratic Socialist Republic of Sri Lanka, Her Excellency Mrs. Chandrika Bandaranaike Kumaratunga met at the Eighth Summit of the South Asian Association for Regional Cooperation (SAARC) at New Delhi, India on 2-4 May 1995.
|
2022-01-23T03:16:44.368Z
|
234,800,395 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.13057/ASIANJFOR/R050106",
"MAG": "3156736977",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Partovi R, Iranbakhsh A, Sheidai M, Ebadi M. 2020. The use of DNA barcoding to avoid adulteration in olive plant leaf products. Asian J For 5: 42-47. The leaves of olive plant species Olea europeae, and O. europeae var. cuspidata have been used for medicinal perfused in Iran. The first species leaves have been used to control the blood pressure, while the leaves of wild olive have been used for abortion by locals. Our preliminary inspection of the medicinal plant market revealed that the leaves of these two olive species are sold mistakenly to the consumers and their health might be at risk. Therefore, we permed this investigation to produce DNA barcodes for correct identification of these two olive species and also identify the potential adulteration in our local market. We used Internal transcribed spacer (ITS), as well as plastid genome trnL-F intergenic spacer and ribosomal protein L16 (rpL16) sequences. These sequences after alignment and curation produced DNA barcodes that can differentiate the two olive species from each other. The phylogenetic trees constructed also separated the samples of these olive species and confirmed the potential use of these short DNA sequences for olive barcoding. The present study revealed that some of the local shops mistakenly sell the wild olive leaves instead of the cultivated olive leaf to be used for blood pressure. This mistake endangers the health of pregnant women consumers if they carry a child. We suggest using a combination of nuclear ITS and plastid intergenic spacer (trnL-F and rpL16) regions for DNA barcoding of olive plants to avoid leaf product adulteration. Keyword: DNA barcoding, medicinal market, olive, rpL16,trnL-F
|
2022-02-07T21:30:55.668Z
|
22,256,260 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/S-0028-1094375",
"MAG": "1986352526",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A NUMBER OF SUCCESSIVE STUDIES CONDUCTED IN ORDER TO INVESTIGATE INTERACTIONS BETWEEN CENTRALLY ACTIVE DRUGS AND ALCOHOL ON DRIVING SKILLS. THE TOTAL SUBJECTS AMOUNT TO 1600 AT PRESENT. DRUGS BELONGING TO DIFFERENT GROUPS IN THE SAME TEST SITUATION ARE COMPARED. SO THE RESULTS AND DIFFERENCES BETWEEN DRUGS WITHIN THE GROUPS ARE COMPARABLE WITH EACH OTHER. SINCE THE DIAZEPAM-ALCOHOL INTERACTION DEMONSTRATED BY THE LABORATORY TESTS PATTERN WAS CONFIRMED BY SIMULATED DRIVING, IT SUGGESTS THAT CAREFULLY SELECTED PSYCHOMOTOR TESTS CAN BE USED AND SHOULD BE USED TO PROVIDE DATA ABOUT THE ACTIONS AND INTERACTIONS OF DRUGS AND ALCOHOL ON DRIVING SKILLS.
|
2022-09-08T00:19:15.503Z
|
39,841,870 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7249/RR754",
"MAG": "62098557",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Assesses the results of a statewide survey to determine language differences among California adults' exposure to suicide prevention messaging, confidence to intervene with someone at risk of suicide, and resource preferences.
|
2022-11-21T18:32:22.620Z
|
4,442,264 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/rcm.8033",
"MAG": "2768905375",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
RATIONALE
Isotopic analysis of archaeological charred plant remains offers useful archaeological information. However, adequate sample pre-treatment protocols may be necessary to provide a contamination-free isotopic signal while limiting sample loss and achieving a high throughput. Under these constraints, research was undertaken to compare the performance of different pre-treatment protocols.
METHODS
Charred archaeological plant material was selected for isotopic analysis (δ13 C and δ15 N values) by isotope ratio mass spectrometry from a variety of plant species, time periods and soil conditions. Preservation conditions and the effectiveness of cleaning protocols were assessed through Fourier transform infrared spectroscopy and X-ray fluorescence (XRF) spectrometry. An acid-base-acid protocol, successfully employed in radiocarbon dating, was used to define a contamination-free isotopic reference. Acid-base-acid isotopic measurements were compared with those obtained from untreated material and an acid-only protocol.
RESULTS
The isotopic signals of untreated material and the acid-only protocol typically did not differ more than 1‰ from those of the acid-base-acid reference. There were no significant isotopic offsets between acid-base-acid and acid-only or untreated samples. Sample losses in the acid-base-acid protocol were on average 50 ± 17% (maximum = 98.4%). Elemental XRF measurements showed promising results in the detection of more contaminated samples albeit with a high rate of false positives.
CONCLUSIONS
For the large range of preservation conditions described in the study, untreated charred plant samples, water cleaned of sediments, provide reliable stable isotope ratios of carbon and nitrogen. The use of pre-treatments may be necessary under different preservation conditions or more conservative measurement uncertainties should be reported.
|
2022-12-03T12:59:09.589Z
|
219,753,241 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.22437/GENTALA.V5I1.9426",
"MAG": "3031253015",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study aims to improve students' speaking skills in science learning through time token models in fifth grade students of SDN 43 / IV Jambi City.
This research is a classroom action research (CAR) consisting of two cycles, where the data taken is in the form of observation data through observation sheets of students' speaking skills and observation sheets of teacher activities. This research was conducted in 4 stages: planning, implementing, observing and reflecting. During the teaching and learning process learning activities apply the time token learning model.
The results of this study indicate the application of the time token model can improve students' speaking skills in natural science subjects. Based on the observation sheet the students' speaking skills showed an increase, with the results of the percentage of students speaking skills by 45% with a fairly good category in the first cycle and 68% with a good category in the second cycle.
Based on the findings of the research, it can be concluded that the speaking skills of science learning students in fifth grade students of SDN 43 / IV Jambi City can be improved after applying the time token model.
|
2022-12-19T07:17:54.424Z
|
93,276,603 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/LA0350608",
"MAG": "1965232964",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The self-aggregation behavior and microscopic characteristics of hydrophobically modified glycol chitosans (HGCs), prepared by covalent attachment of 5β-cholanic acid to glycol chitosan, were investigated by using 1H NMR, dynamic light scattering, fluorescence spectroscopy, and transmission electron microscopy (TEM). The HGCs formed self-aggregates in an aqueous phase by intra- or intermolecular association between hydrophobic 5β-cholanic acids attached to glycol chitosan. The critical aggregation concentrations (cacs) of the HGCs were dependent on the degree of substitution (DS) of 5β-cholanic acid and were significantly lower than those of low molecular weight surfactants. The mean diameters of the self-aggregates decreased with the increase in the DS of 5β-cholanic acid because of the formation of compact hydrophobic inner cores. The TEM images demonstrated that the shape of the self-aggregates, on the basis of the HGCs, is spherical. The partition equilibrium constants (Kv) of pyrene, measured in the ...
|
2022-12-19T10:51:34.406Z
|
4,908,116 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/jopr.12492",
"MAG": "2469282801",
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},
"license": null,
"status": null,
"url": null
}
|
The fabrication of an implant-supported fixed complete denture prosthesis involves multiple clinical and laboratory steps. One of the main steps is to provide the patient with an interim fixed prosthesis to evaluate the patient's esthetic and functional needs as well as to enhance the patient's psychology before proceeding to the definitive prosthesis. Different techniques for fabricating interim prostheses have been described in the literature. This report describes an alternative technique that uses a duplicate denture made of self-curing acrylic resin to fabricate an implant-supported fixed interim prosthesis. The interim prosthesis was later used as a blueprint for the definitive implant-supported hybrid prosthesis.
|
2023-01-01T19:28:18.544Z
|
120,944,848 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1121/1.4708418",
"MAG": "1990507804",
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},
"license": null,
"status": null,
"url": null
}
|
The statistical uncertainty in acoustical testing has been insufficiently studied in the acoustical community, and the effects of the uncertainties have been largely ignored. Most acousticians do not know what the reproducibility limit is for acoustical test results from accredited laboratories, but tacitly assume that the limits are on the order 1 or 2 rating points. In recent years the authors have demonstrated that the uncertainties in acoustical laboratory testing in the United States are much higher than most people have realized [LoVerde and Dong, J. Acoust. Soc. Am. 125, 2629 (2009), J. Acoust. Soc. Am. 126, 2171 (2009) J. Acoust. Soc. Am. 130, 2355 (2011)]. The typical acoustician's reaction is that it should be possible to measure to higher precision with suitable changes to the test methodology, and improving the precision of laboratory testing is an important goal that deserves much more attention than it has received. However, there is no guarantee that it will be practical to substantially de...
|
2022-02-09T20:35:33.649Z
|
124,189,340 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5860/choice.30-2739",
"MAG": "2255045007",
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},
"license": null,
"status": null,
"url": null
}
|
Twenty-four centuries ago, the Greek
philosopher Democritus and his teacher
Leucippus gave birth to a new way of
thinking about matter's invisible and
elementary entity, the atom. Democritus's atomism was born on a purely
philosophical basis, surely without
anticipating some of this century's
most triumphant scientific discoveries
- atoms can now be seen, seen in
motion and manipulated. Von Baeyer
vividly and eloquently describes the
past, present and future of atomism.
His account of present-day discoveries is
largely centred on the three fundamental
dimensions, space, time and
number, and is written in a coherent
and personal style. As Roald Hoffman
notes on the dust jacket, the author
has provided a striking verbal picture
of the contemporary scene of physics
and chemistry.
|
2022-02-09T18:30:50.961Z
|
71,418,970 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1055-9965.DISP-11-B6",
"MAG": "1979735420",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: The Region Five GMaP/BMaP Network is a regional partnership representing 18 NCI funded institutions charged with the implementation of a comprehensive needs assessment (CNAT). This presentation focuses on preliminary findings from the Biospecimen Facility Survey. Methods: The CNAT consisted of a mixed methods approach utilizing four instruments: A principal Investigator Survey and PI Interview and a Biospecimen Facility Survey and Interview. The surveys were conducted online during the months of March/ April 2011. Interviews will be conducted in July. The goal of the biospecimen facility survey which is the focus of this abstract is to assess minority biospecimen collection, biobanking practices, education, and outreach initiatives. The biospecimen survey consisted of 14 distinct questions, with affiliated subset questions, across five areas. These questions captured details from the institutions’ core facilities and inventory human specimens that were available for research. The survey was completed online by 10 biospecimen facility administrators. Results: Preliminary findings consistently reported disparities in biospecimen collection among minority populations. Eight out of ten facilities reported the types of cancer and racial and ethnic groups from whom they collected specimens. Upon close review of the data, gaps in specimens collected for populations with a high burden of cancer were commonly identified. Seven facilities reported having collected specimen from 116,417 White patients vs. 12,592 Non-White (minority) patients’ and 1648 Hispanic patients’. Tissue (diseased and healthy) was most commonly collected and bodily fluids were least commonly collected. While 40% of the biospecimen facilities have collaborated on biospecimen education efforts, we have learned that 60% of these facilities have collaborated on projects that collect specimens for the study of health disparities. The data mirrors similar findings from the PI survey; over half of our PIs are involved in biospecimen education and minority collection efforts. In reference to bioinformatics and electronic data systems we found that 100% of the Region Five facilities currently use electronic annotation systems for biospecimen collection. However, there is a wide range of data systems/platforms used across the institutions which raise issues of compatibility. Along with this, we have found that 94% of specimens collected by our facilities have associated pathology data available. Biospecimen facility administrators identified barriers which limit them from collaborating in collection programs. However, they also indicated a high desire to collaborate. Conclusions: There is a need to focus on minority biospecimen collection efforts and address the gaps in how race and ethnicity and subtypes of biospecimens are collected across our institutions. Region Five is exploring ways to share instruments and methodologies used to collect race and ethnicity and develop strategies to standardize patient information collected. We anticipate implementing Cancer 101 and 102 education and training on research participation, biospecimen donation/biobanking and genetics across our institutions. In addition, there are opportunities for collaboration among principal investigators and biospecimen facilities around minority specimen collection efforts. Citation Information: Cancer Epidemiol Biomarkers Prev 2011;20(10 Suppl):B6.
|
2022-02-11T10:46:20.358Z
|
249,708,847 |
{
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"DOI": "10.1371/journal.pone.0268857",
"MAG": null,
"PubMedCentral": "9200292"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0268857&type=printable"
}
|
Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. FQI1, the initial lead compound identified, unexpectedly induced a concentration-dependent delay in mitotic progression. Here, we show that FQI1 can rapidly and reversibly lead to mitotic arrest, even when added directly to mitotic cells, implying that FQI1-mediated mitotic defects are not transcriptionally based. Furthermore, treatment with FQIs resulted in a striking, concentration-dependent diminishment of spindle microtubules, accompanied by a concentration-dependent increase in multi-aster formation. Aberrant γ-tubulin localization was also observed. These phenotypes suggest that perturbation of spindle microtubules is the primary event leading to the mitotic delays upon FQI1 treatment. Previously, FQIs were shown to specifically inhibit not only LSF DNA-binding activity, which requires LSF oligomerization to tetramers, but also other specific LSF-protein interactions. Other transcription factors participate in mitosis through non-transcriptional means, and we recently reported that LSF directly binds α-tubulin and is present in purified cellular tubulin preparations. Consistent with a microtubule role for LSF, here we show that LSF enhanced the rate of tubulin polymerization in vitro, and FQI1 inhibited such polymerization. To probe whether the FQI1-mediated spindle abnormalities could result from inhibition of mitotic LSF-protein interactions, mass spectrometry was performed using as bait an inducible, tagged form of LSF that is biotinylated by endogenous enzymes. The global proteomics analysis yielded expected associations for a transcription factor, notably with RNA processing machinery, but also to nontranscriptional components. In particular, and consistent with spindle disruption due to FQI treatment, mitotic, FQI1-sensitive interactions were identified between the biotinylated LSF and microtubule-associated proteins that regulate spindle assembly, positioning, and dynamics, as well as centrosome-associated proteins. Probing the mitotic LSF interactome using small molecule inhibitors therefore supported a non-transcriptional role for LSF in mediating progression through mitosis.
|
2022-07-19T11:35:28.261Z
|
77,389,410 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICCONS.2018.8663056",
"MAG": "2921801459",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Icebergs make nature as beautiful as well number of limitations also existed with them like, growth of phytoplankton in water, Gas production effects, shipping problems. A number of various satellite sensors have been using for monitoring the Icebergs wherever they were existed. This result can help to reduce the threats from the effect of the Icebergs by taking the precautions over the premises of the icebergs. In this paper, transformation techniques based methodology has established for identifying the icebergs in the standard database images. This can able to detect not only the larger icebergs, can also identify smaller and medium icebergs. This methodology has given 96% efficient results in the process of detection of the icebergs. The main strength of this work is literature survey on related works with the analysis report on the results.
|
2022-09-09T00:10:19.213Z
|
228,757,351 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5944/RIF.13.2016.29613",
"MAG": "3043493983",
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"license": null,
"status": null,
"url": null
}
|
espanolEl articulo tiene por objetivo analizar ciertos pasajes fundamentales de la Wissen-schaftslehre y de las Paradoxien des Unendlichen de Bernard Bolzano en cuanto al analisis conjuntista se refiere. En dichos pasajes, Bolzano desarrolla conceptos fundamentales tales como multitud, coleccion e infinito que anticipan el caracter conjuntista y del analisis mate-matico moderno. Asimismo, se presentara un breve estudio de las Contribuciones a una mas fundada exposicion de la matematica y el apendice, Sobre la teoria kantiana de la construccion de conceptos a traves de intuiciones, textos donde Bolzano muestra su rechazo de Kant. EnglishThe article addresses the treatment of certain fundamental passages from Bolzano’s Wissenschaftslehre and Paradoxien des Unendlichen. In these passages, Bolzano describes some of his key concepts such “Multitude”, “Collections” and “Infinite” in the context of mathematical analysis and Set theory. Therefore, I discuss at length the (almost) unknown Contributions to a Better-Grounded Presentation of Mathematics and the appendix On the Kantian Theory of the Construction of Concepts through Intuitions, texts where Bolzano shows its rejection of Kant.
|
2022-01-27T16:22:54.058Z
|
2,994,340 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/thx.48.5.474",
"MAG": "2159067304",
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},
"license": null,
"status": "BRONZE",
"url": "https://thorax.bmj.com/content/thoraxjnl/48/5/474.full.pdf"
}
|
BACKGROUND--Photodynamic therapy (PDT) is a technique for producing localised tissue necrosis with light after prior administration of a photosensitising drug. There is some selectivity of uptake of photosensitisers in malignant tissue, although this is difficult to exploit. Full thickness necrosis in normal and neoplastic colon heals without perforation because of a lack of effect on collagen, making local cure a possibility. The experiments described here aim to establish whether these conclusions are also valid for bronchial tumours. METHODS--In pharmacokinetic studies normal rats were given 5 mg/kg of the photosensitiser aluminium sulphonated phthalocyanine (A1SPc) intravenously and killed up to one month later. The distribution of A1SPc in the trachea was measured by chemical extraction and fluorescence microscopy. In subsequent experiments sensitised animals were treated with light delivered to the tracheal mucosa through a thin flexible fibre and the resultant lesions were studied for their size, mechanical strength, and healing. A series of resected human bronchial carcinomas were examined histologically for their collagen content. RESULTS--The tracheal concentration of A1SPc in normal rats was maximum 1-20 hours after administration. Fluorescence microscopy revealed that most was in the perichondrium and submucosal stroma, with little in the cartilage. Light exposure showed necrosis of the soft tissues which healed by regeneration, but no effect on cartilage and no reduction in the mechanical strength of the trachea at any stage. Histological examination of resected human bronchial carcinomas showed more collagen in the tumour areas than would be found in normal regions. CONCLUSIONS--PDT leads to necrosis of the soft tissues of the normal trachea but there is complete healing by regeneration, no risk of perforation (due to collagen preservation), and no effect on cartilage. Human bronchial carcinomas apparently contain more collagen than normal bronchi which may give protection against perforation following necrosis induced by PDT. PDT may have a role in eradicating small volumes of tumour tissue in situ and could be valuable for treating (1) small carcinomas in patients unfit for resection, (2) tumour remaining after surgical resection, (3) stump recurrences, or (4) to prolong palliation of tumours after debulking with the NdYAG laser.
|
2022-12-09T04:13:31.695Z
|
85,875,637 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1590/0100-67622015000200012",
"MAG": "2164135375",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://www.scielo.br/pdf/rarv/v39n2/0100-6762-rarv-39-02-0325.pdf"
}
|
The Pantanal biome may be considered a hyperseasonal environment where there is a flooded period followed by an extended dry period with very high temperatures. The diversity of vegetation types modify the input of carbon into the soil in different quantity and quality. With this focus, this study aimed to verify the effect of the hydrological Pantanal Cycle (rising, flood, low tide and dry season), on the dynamics of soil organic carbon stock in different vegetation types of Cambarazal, Riparian Forest, Mountain Range and Thorn-Scrub. Principal component analysis (PCA) identified three distinct groups, characterized by nutrient reserves and by soil acidity. The carbon stock of the soil is conditioned by seasonal factors and equally dependent on the local vegetation type that occurred in vegetation types that showed the highest level of natural fertility, respectively, Cambarazal and Thorn-Scrub. The highest carbon content was observed during the flood period, for most vegetation types and the lowest carbon stock occurred during the period of low tide in 2008, just after a period of anaerobiosis due to the flood and before the dry season became predominant.
|
2022-12-30T01:03:42.782Z
|
58,916,149 |
{
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"ArXiv": null,
"DOI": "10.4081/GI.2010.E3",
"MAG": "2132932331",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Fructose has several interactions in man, including intolerance and promotion of some diseases. However, fructose in fruits and in prebiotics may be associated with benefits. Adaptation to regular fructose ingestion as defined for lactose could support a beneficial rather than a deleterious effect. This study was undertaken to evaluate symptomatic response and potential underlying mechanisms of fecal bacterial change and breath hydrogen response to short term regular fructose supplementation. Forty-five participants were recruited for a 3 day recall diet questionnaire and a 50 g fructose challenge. Breath hydrogen was measured for 4.5 hrs and symptoms were recorded. Thirty-eight subjects provided stool samples for analysis by selective culture of 4 groups of bacteria, including bifidobacteria and lactobacilli. Intolerant subjects returned a second time 15 days later. Ten of these served as controls and 16 received 30 g fructose twice a day. Ten of the latter returned 27 days later, after stopping fructose for a third challenge test. Student’s paired, unpaired t-tests and Pearson correlations were used. Significance was accepted at P<0.05. After fructose rechallenge there were no significant reductions in symptoms scores in volunteers in either the fructose supplemented or non supplemented groups. However, total breath hydrogen was reduced between test 1 and test 2 (P=0.03) or test 3 (P=0.04) in the group given fructose then discontinued, compared with controls. There were no statistically significant changes in bacterial numbers between test 2 and 1. This study shows that regular consumption of high dose fructose does not follow the lactose model of adaptation. Observed changes in hydrogen breath tests raise the possibility that intestinal carriers of fructose may be induced potentially aggravating medical problems attributed to fructose.
|
2022-03-06T02:07:50.139Z
|
55,999,918 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.11648/J.IJEMA.20130102.12",
"MAG": "2151549044",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In view of the global importance of wetlands in providing food and income for millions of people through agricultural activities, efforts should be geared toward identifying appropriate biomonitoring organisms for them. This study investigated the mortality and burrowing responses of Libyodrilus violaceus earthworm to heavy metals in the laboratory. The worms were subjected to heavy metal spiked soil in graded concentrations following the procedure recommended by the Organization for Economic Cooperation and Development for a period of 14 days. Zn had the highest significant mean lethal effect (6.35±4.04) on this species, followed by the mixtures of Zn, Cd (5.90±5.05); Zn, Pb, Cd (5.40±4.5); Zn, Pb (5.05±4.37), in that order. The median lethal concentration (LC 50) values for zinc (Zn), lead (Pb), and cadmium (Cd) obtained from the study stood at 520.06, 1551.55, and 706.66 mg/kg soil respectively. The species also showed inhibited burrowing responses to these metals in individual and combined concentrations. It is concluded that L. violaceus should be a candidate for con-sideration in assessing the health of wetland soils.
|
2022-04-22T04:46:05.041Z
|
214,485,362 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1096/fasebj.2019.33.1_supplement.438.1",
"MAG": "2998067300",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.1096/fasebj.2019.33.1_supplement.438.1"
}
|
Anatomy educators have become leaders in the Scholarship of Teaching and Learning (SoTL) within the biomedical sciences. Our classrooms and laboratories are learning hubs filled with innovative, evidence‐based pedagogies that we commonly systematically evaluate for learning effectiveness. As we continue to push the boundaries of innovative teaching, we must be careful to ensure we are developing, implementing, and disseminating education research projects with strong and resilient designs. Within the broad field of SoTL and education research there are common design flaws that can be avoided with careful preparation and forethought. Specifically, this presentation will focus on six themes of education research each with common concerns: 1) selecting an appropriate methodology and data collection strategy that best aligns with the specific research question(s), 2) establishing appropriate and informative comparison groups, 3) using randomization to control for between‐student factors (and to avoid self‐selection bias), 4) including appropriate considerations of power differential when using one's own students as research participants, 5) obtaining informed consent in a manner that respects student autonomy, and 6) selecting robust statistical analyses that fit the research design. Each theme will be thoroughly expanded upon in the context of the anatomy classroom/laboratory with concrete, practical suggestions for effective and meaningful SoTL projects. Positive examples will be extracted from recently published works to showcase exemplary research designs in the field. Ultimately, the goal of this presentation is to initiate and fuel constructive conversations on education research design elements; a conversation that will benefit junior and senior anatomy educators alike. By encouraging and facilitating strong, resilient, and thoughtful education research projects, anatomy educators can continue to be at the forefront of innovative SoTL practices that enhance learning for our students and positively impact biomedical education at large.
|
2022-07-09T12:03:32.166Z
|
62,838,056 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18260/p.24911",
"MAG": "2599505218",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://peer.asee.org/24911.pdf"
}
|
With the percentage of women in STEM majors at Texas State University, a large Hispanic Serving Institution, significantly lower than the percentage of women attending the university in general, the authors sought to understand this gap by studying the perspectives of undergraduate women who have successfully persisted in a STEM field of study at the same university. Specifically, the goal of this study was to gain a deeper understanding of what experiences women credited for influencing their self-efficacy, the development of their career interest goals and their academic course outcomes as related to studying science, technology, engineering and mathematics (STEM). This study is unique in that it was also designed to identify experiences that appear to contribute to women’s identity development and self-confidence and includes a substantial representation of Latina women’s voices. Data was collected and analyzed to identify if similar patterns exist between subjects and if so, which are the greater influencers in their decision to select a STEM major and to persist beyond the critical first two years of undergraduate studies. The literature of socialization and identity development as related to women as STEM learners in diverse communities is reviewed. This study begins to create an understanding of how women think about their multiple social identities (field of study, gender, culture, etc.). Focus group strategies for obtaining in-depth feedback regarding young women’s attitudes, perceptions, motivations, and behaviors are discussed. Observations and recommendations regarding the research methodologies for study design and data analysis are presented with particular attention to the rationale for cultural responsive practices in qualitative research. A mixed methods research approach including the use of surveys and focus groups was used to collect student perceptions from junior and senior status students in STEM fields of study. Preliminary results indicate that students identify early personal experiences as building their self-confidence and contributing to their identity development. Drawing on self-perception theory, women appear to develop a more robust sense of persistence and feel that they fit into STEM; even when faced with sexism from other students. Background When retention theories first evolved 45 years ago, the issue was viewed through the lens of psychology. Student retention was thought to be a function of individual motivation, attributes, and skills; thus, students failed, not institutions. From the 1970s onward, this view of retention yielded to one focused on the relationship between students and society. As a result, greater emphasis was placed on the role of institutions in students’ decisions on whether to stay or leave. Since then, several major theories/models have tried to explain student retention/attrition; the Center for the Study of College Student Retention lists as many as eight. Tinto’s model paved the way for a sociological analysis of retention that has been popular for several decades and it postulates that persistence occurs when students successfully integrate into the institution academically and socially. Integration, in turn, is influenced by pre-college characteristics and goals, interactions with peers and faculty, out-of-classroom socialization, and personal family dynamics and acculturation factors. Additionally, Tinto argues that the first year of college,
|
2022-08-20T11:33:54.754Z
|
219,315,770 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/2175-8239-JBN-2020-0043",
"MAG": "3031539321",
"PubMedCentral": "7427653"
},
"license": null,
"status": null,
"url": null
}
|
Donor-specific antibodies (DSAs) directed against HLA antigens are central to the development of antibody-mediated rejection and chronic allograft vasculopathy, the leading causes of long-term transplant failure. DSAs can be preexisting (preformed) or arise de novo (dnDSA) following transplantation. Preformed DSAs occur through previous exposure to alloantigens after blood transfusion, pregnancy or prior transplant. Because preformed DSAs significantly increase the risk of antibody-mediated rejection (ABMR), organs expressing the target antigens of the DSAs are avoided if possible. Using solid-phase, single antigen [...]
|
2022-09-02T21:13:50.987Z
|
15,157,475 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.19026/RJASET.7.754",
"MAG": "2187530513",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Forming a logical balance between the quality of the file and the scope of data that can be conveyed is the test of steganographic techniques to form such a balance. On top of that, the facts that cannot be covered up are the robustness of the method and security of the vague data. An insertion method which delivers a high level of visual quality and a huge amount of volume for the obscured data is called the Least Significant Bit (LSB), but the concealed message is poorly secured through this technique. In the recommended approach, the Vigenere encryption techniques initially used to encode the secret data to assure the safety of the concealed message. Later, the data is contracted through the Huffman coding method in order to decrease the occupational volume of the classified data. Then, each bit stream of the data is dispersed out onto the image to enhance the robustness of the technique by using the expanded knight tour algorithm. The outcomes show that apart from enhancing the visual quality of the stego image, the recommended technique enhances the safety and payload capacity issues of the simple LSB technique.
|
2022-09-09T20:57:29.973Z
|
148,619,404 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21032/JHIS.2017.42.2.116",
"MAG": "2625107489",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objectives: This study analyzes how financial issues major causes of conflicts within families-affect depression of individuals, and tests the intermediary effects of self-esteem and physical health between the financial issues and depression. For the analysis, this study uses part of the general household member data, which is included in the ‘Prevalence of conflicts and social pathologies at individual level and counter measures in Korea’ conducted by the Korea Institute for Health and Social Affairs (KIHASA), as secondary data. Methods: We used multiple-group structural model to test the effects of family conflict, self-esteem, and physical health on the depression. The findings of this study can be summarized as follows. Financial issues were the major factor that increased depression caused by family conflicts. Also, family conflicts arising by financial issues significantly reduced self-esteem. Self-esteem have a greater negative correlation than physical health on depression. In addition, family conflicts affected depression, self-esteem, and physical health among groups of different ages, sexes, and income levels by the multiple-group structural model analysis. Results: This test analyzes the significance and direction of the indirect effect exerted by self-esteem and physical health on depression caused by family conflicts. The higher a person’s sense of self-esteem and the healthier a person is, the less severe his or her depression will be. The control variables, such as age, sex, income, also exert partial intermediary effects. Conclusions: Most importantly, society as a whole needs to care more about women and the elderly who are prone to depression associated with family conflicts, and policymakers must make available a broader range of mental health services that cater to the particular needs and characteristics of women and the elderly.
|
2022-12-19T01:50:09.285Z
|
199,057,136 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21873/anticanres.13609",
"MAG": "2965028165",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://ar.iiarjournals.org/content/39/8/4393.full.pdf"
}
|
Background/Aim: Metastatic breast cancer (MBC) represents a wide spectrum of heterogeneous conditions with different secondary spread sites, time to relapse and biology. MBC is still considered an incurable disease despite the fact that survival rates have improved in the last years. Cutaneous metastases are a rare site for metastatic spread and indicate advanced disease. The aim of this study is to demonstrate the excellent therapeutic result following endocrine therapy only in MBC with just skin involvement. Case Report: We present a case of an 82-year-old woman with no family history of breast cancer (BC), who was diagnosed with de novo metastatic estrogen/progesterone receptor-positive and HER2-negative invasive lobular BC. The only site of secondary spread was the skin. She was treated with just endocrine therapy for 116 months with which she achieved and maintained long-term complete clinical response (CR). Discussion: To our knowledge this is the only case of lobular BC with de novo metastatic manifestation as multiple skin metastases, which achieved CR following the aromatase inhibitor treatment (anastrozole) with such impressive long-term overall survival.
|
2022-12-31T18:25:44.655Z
|
118,443,124 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.4064/AA-83-2-117-126",
"MAG": "996834647",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
where c > 1 is not integer, and proved in both cases that there exists k0(c) such that the corresponding problem has solutions if k ≥ k0 and N is sufficiently large. Later Deshouillers [4] and Arhipov and Zhitkov [1] improved Segal’s result on (2). One may also mention the papers of Deshouillers [5] and Gritsenko [7], where the equation (2) in two variables was considered. In 1952 I. I. Piatetski–Shapiro [12] considered (1) with x1, . . . , xk restricted to prime numbers. Let H(c) denote the least k such that the inequality (1) with fixed e > 0 has solutions in prime numbers for every sufficiently large real N . Piatetski–Shapiro proved that
|
2022-12-31T20:35:19.230Z
|
161,734,671 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1353/mar.2015.0058",
"MAG": "1636156872",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
<abstract/>
|
2022-02-08T22:05:06.204Z
|
226,146,301 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31392/npu-nc.series15.2019.1(121)20.01",
"MAG": "3035907271",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://spppc.com.ua/index.php/journal/article/download/27/25"
}
|
Recreational well-being in the elderly contributes to the preservation and enhancement of health, improving the adaptive capacity of their body, reducing the frequency of exacerbations of chronic diseases and improving the psycho-emotional sphere of man. The purpose of the research is to synthesize the basic directions of optimization of the recreational and health activity of elderly people on the basis of theoretical analysis. Research methods: study and analysis of scientific and methodological literature, induction and deduction, comparison and generalization. Results: On the basis of theoretical analysis of scientific and methodological literature and our own experience, we have synthesized the main directions of recreational and recreational activity of the elderly, namely: places of mass rest, University of the Third Age, All-Ukrainian Center for Physical Health of the Population "Sport for All", fitness -club, sanatorium and recreational establishments, health groups, interest groups in sports facilities, health groups in medical institutions. In places of mass recreation, namely in parks of culture and recreation, by place of residence, elderly people can engage in recreational and recreational activities without taking into account their social, material status. Within the walls of a third-century university, recreational and recreational activities are a form of cognition, education and socialization for students of this institution. The "Recreation and Recreation Activities for Older Age" also includes "Sport for All", which helps to engage people in physical activity during leisure activities to promote health. In health resorts and recreational establishments, recreational and recreational activities are implemented in the rest mode, taking into account his health status and recreational resource of the establishment.
|
2022-05-30T07:15:29.146Z
|
42,302,803 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1161/01.CIR.56.2.328",
"MAG": "1996499748",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the control trial of low-dose heparin among 4,121 patients, referred to by the Council, Kakkar reported 158 cases (7.7%) of wound hematomas and 182 cases (8.9%) of excessive bleeding in 2,045 heparin-treated patients for a combined complication rate of 16.6%. The Special Report mentioned only 158 cases and mislabeled these as "excessive bleeding." Many surgeons who are familiar with Kakkar's work have not thoroughly analyzed his data; the inaccuracies in the Special Report could be misleading. H. LEON PACHTER, M.D. THOMAS S. RILES, M.D. New York University Medical Center New York, New York 10016
|
2022-07-29T10:24:37.495Z
|
12,645,045 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ECTC.2014.6897464",
"MAG": "1988635925",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Predominant high melting point solders for high temperature electronics (operating temperatures from 200 to 250 C) are Pb-based but these are hazardous to environment. In this study, we designed and characterized the `new' Bi-based solder alloys, 78Bi-14Cu-8Sn and 70Bi-20Sb-10Cu, to understand their performance for high temperature die attach applications. The specific alloy compositions were determined by thermodynamics calculations via the Thermo-Calc software to have a solidus temperature above 271 C. Microstructures of the selected as-cast alloys have shown Cu3Sn and Cu2Sb intermetallic compounds (IMCs) spread in Bi or Bi-Sb matrix, respectively, which are essential for maintaining good thermal conduction and high temperature strengths. Die-attach solder joints were replicated using a Cu substrate, a solder preform and a Ti/Ni/Au metallized Si die, to study interfacial reactions and joint microstructure. In this paper, microstructure - property relationships of high-Bi alloys are highlighted to assess their potential as a high temperature Pb-free solder. In particular, we examined the reactivity of these solders with common surface finishes (e.g., Ni/Au, Cu) of the die and the substrate at various reflow conditions. It was shown that strong reaction exists between Bi and Ni (BiNi), between Sb and Ni (NiSb), and between Sb and Cu (Cu2Sb, Cu4Sb), but the reaction in the case of 78Bi-14Cu-8Sn was rather weak with Cu (forming Cu3Sn) due to the limited supply of Sn from the Bi matrix. The die shear testing was also performed on these sandwiched coupons to evaluate their solder performance at various reflow conditions. The die attach with 70Bi-20Sb-10Cu showed as-reflowed die shear strengths over 30 MPa, which were comparable to or better than high-Pb alloys.
|
2022-08-25T10:23:27.720Z
|
83,646,140 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1002/ARCH.940030104",
"MAG": "1969537427",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The distribution and biosynthesis of ecdysone and 20-hydroxyecdysone (20-OH-ecdysone) was followed in sugar- and blood-fed female Aedes aegypti. In both sugar- and early blood-fed animals most of the ecdysteroid determined by radioimmunoassay was found outside the ovary. Twenty-four to 40 h after blood feeding, however, ecdysteroid was distributed between ovary and carcass in the ratio of 1:1.5. Ecdysteroid titer reached a plateau between 18 to 40 h after the blood meal and decreased thereafter. Analysis of the ecdysteroid titer using thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) revealed that both 20-OH-ecdysone and ecdysone were synthesized after the blood meal. The ratio of 20-OH-ecdysone to ecdysone remained essentially constant and fluctuated in parallel throughout egg development. Chromatography of the early ecdysteroid peak (8 h after feeding) using TLC and HPLC indicated that although it cross-reacted with ecdysteroid antibodies, it did not have the same elution times as ecdysone and 20-OH-ecdysone and is, therefore, probably a precursor of these ecdysteroids. Injections of egg development neurosecretory hormone (EDNH) preparation purified to near homogeneity, into ligated abdomens, induced ecdysteroid synthesis only if the abdomens were first treated with methoprene (12.5 pg). Methoprene at this concentration did not stimulate ecdysteroid synthesis in these abdomens. When blood-fed females were treated with [4-14C] cholesterol and analyzed using TLC and HPLC procedures, both [14C]labeled ecdysone and [14C]labeled 20-OH-ecdysone were synthesized in the ratio of 1:1.5. This report is the first to show that both ecdysone and 20-OH-ecdysone are synthesized in vivo in female A. aegypti.
|
2022-09-05T07:15:32.568Z
|
31,076,869 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2196/jmir.5786",
"MAG": "2466447226",
"PubMedCentral": "4945823"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.2196/jmir.5786"
}
|
Background The Sydney West Translational Cancer Research Centre is an organization funded to build capacity for translational research in cancer. Translational research is essential for ensuring the integration of best available evidence into practice and for improving patient outcomes. However, there is a low level of awareness regarding what it is and how to conduct it optimally. One solution to addressing this gap is the design and deployment of web-based knowledge portals to disseminate new knowledge and engage with and connect dispersed networks of researchers. A knowledge portal is an web-based platform for increasing knowledge dissemination and management in a specialized area. Objective To measure the design and growth of an web-based knowledge portal for increasing individual awareness of translational research and to build organizational capacity for the delivery of translational research projects in cancer. Methods An adaptive methodology was used to capture the design and growth of an web-based knowledge portal in cancer. This involved stakeholder consultations to inform initial design of the portal. Once the portal was live, site analytics were reviewed to evaluate member usage of the portal and to measure growth in membership. Results Knowledge portal membership grew consistently for the first 18 months after deployment, before leveling out. Analysis of site metrics revealed members were most likely to visit portal pages with community-generated content, particularly pages with a focus on translational research. This was closely followed by pages that disseminated educational material about translational research. Conclusions Preliminary data from this study suggest that knowledge portals may be beneficial tools for translating new evidence and fostering an environment of communication and collaboration.
|
2022-09-12T19:16:48.098Z
|
103,874,408 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.5023188",
"MAG": "2795393339",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://aip.scitation.org/doi/pdf/10.1063/1.5023188"
}
|
A new type of three-dimensional (3D) detector, namely 3D-Open-Shell-Electrode Detector (3DOSED), is proposed in this study. In a 3DOSED, the trench electrode can be etched all the way through the detector thickness, totally eliminating the low electric field region existed in the conventional 3D-Trench-Electrode detector. Full 3D technology computer-aided design (TCAD) simulations have been done on this novel silicon detector structure. Through comparing of the simulation results of the detector, we can obtain the best design of the 3SOSED. In addition, simulation results show that, as compared to the conventional 3D detector, the proposed 3DOSED can improve not only detector charge collection efficiency but also its radiation hardness with regard to solving the trapping problem in the detector bulk. What is more, it has been shown that detector full depletion voltage is also slightly reduced, which can improve the utility aspects of the detector. When compared to the conventional 3D detector, we find tha...
|
2022-11-20T14:25:37.394Z
|