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12,293,245 |
{
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"DOI": "10.1111/j.1651-2227.1994.tb13081.x",
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We read with great interest the letter from Scheinin et al. They report that responses to purified protein derivative (PPD) do not change with increasing age. In our study, a rapid decrease in tuberculin skin test reactivity 4-6 years after neonatal BCG vaccination was found. We did not compare reactions in children born in different years or in children vaccinated with different BCG vaccines or between the 1970s and 1980s. Neither did we use the classification of children according to year of birth, as indicated in the letter. Straightforward comparison of these two studies is difficult, or even impossible, to perform. First, none of the children in our study was a diabetic or otherwise immunocompromised and therefore our results can be compared only with the non-diabetic controls in the study of Scheinin et al. Second, the age range in our study was narrow (4.3-6.3 years); for example, in the age group > 5.5 years, the children in our study were 5.5-6.3 years of age compared with up to 15 years of age in the study of Scheinin et al. This is of great importance since the response to PPD is known to be influenced by contact with environmental mycobacteria (1). The reactivity is known to increase with increasing age between 6 and 11 years, as has been shown in skin test studies in non-vaccinated children in a Nordic environment (2, 3). The same applies to BCGvaccinated healthy Finnish children. as shown by identical studies performed by Tala-Heikkila et al. (4) and Kroger et al. (5). When the results of these two studies are compared it appears that the results obtained by the two techniques show similar PPD responsiveness with age, although one study examined cell proliferation responses in vitro and the other skin responses in vivo. In Finland, BCG revaccinations at school age have been stopped (6). We consider the results of the study by Scheinin et al. as interesting additional information on the discussion about immunity against tuberculosis. In the near future, the benefits of BCG vaccination in newborns will be evaluated. We also need results from different studies using different approaches and methods.
|
2022-12-19T13:07:52.660Z
|
221,090,107 |
{
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"ACL": null,
"ArXiv": "2008.03840",
"DOI": "10.1063/5.0015446",
"MAG": "3101862569",
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"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/2008.03840"
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|
We present a continuum theory of electrolytes composed of a waterlike solvent and univalent ions. First, we start with a density functional F for the coarse-grained solvent, cation, and anion densities, including the Debye-Hückel free energy, the Coulombic interaction, and the direct interactions among these three components. These densities fluctuate obeying the distribution ∝exp(-F/kBT). Eliminating the solvent density deviation in F, we obtain the effective non-Coulombic interactions among the ions, which consist of the direct ones and the solvent-mediated ones. We then derive general expressions for the ion correlation, the apparent partial volume, and the activity and osmotic coefficients up to linear order in the average salt density ns. Second, we perform numerical analysis using the Mansoori-Carnahan-Starling-Leland model [J. Chem. Phys. 54, 1523 (1971)] for three-component hardspheres. The effective interactions sensitively depend on the cation and anion sizes due to competition between the steric and hydration effects, which are repulsive between small-large ion pairs and attractive between symmetric pairs. These agree with previous experiments and Collins' rule [Biophys. J. 72, 65 (1997)]. We also give simple approximate expressions for the ionic interaction coefficients valid for any ion sizes.
|
2022-12-19T01:35:03.551Z
|
23,295,573 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1046/j.1440-1746.2000.02257.x",
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"license": null,
"status": null,
"url": null
}
|
Abstract Hepatocellular carcinoma (HCC) has ranked second in cancer mortality in China since the 1990s and is increasing in frequency among males in many countries. Hepatitis B and C viruses, aflatoxin and algal toxin in the contaminated drinking water remain major aetiological factors and hepatitis G virus and transfusion‐transmitted virus can not be excluded. A prospective randomized control trial screening for HCC in a high‐risk population using alpha fetoprotein (AFP) and ultrasonography has demonstrated a decrease in HCC mortality. Rapidly progressing medical imaging has continuously contributed to the improving treatment results. Surgical resection still plays a major role in influencing prognosis of HCC. Studies on recurrence and metastasis after curative resection have become a key issue for further improvement of the surgical outcome. Regional cancer therapies are progressing rapidly, based on the advances in early diagnosis. The advantages and disadvantages of these are noted. Multimodality combination and sequential treatment has been accepted as an important approach for unresectable HCC and cytoreduction and sequential resection have attracted attention. Conformal radiotherapy has shown important potential for HCC treatment. Intra‐arterial chemotherapy has been repeatedly proved effective; however, systemic chemotherapy for HCC remains disappointing. The effects of tamoxifen are questionable, whereas α‐interferon has been shown to have significant potential, particularly in prevention of recurrence. All of these treatments have resulted in continuing improvement of HCC prognosis in some centres.
|
2022-12-19T02:36:09.158Z
|
90,552,733 |
{
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"ArXiv": null,
"DOI": "10.1590/1809-43921979094723",
"MAG": "2600528082",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.scielo.br/j/aa/a/wGNBHr3YYFSh3zWztBQmttG/?lang=pt&format=pdf"
}
|
The teleostean ovocytes in phase pre-vitelogenic show numerous nucleoli In the nucleus periphery. Morphological evidences indicate that the nucleolar material is transfered to the cytoplasm whese it associate with mitochondria. Later this dense material of nucleolar origin disperse in the cytoplasm always associated to the mitochondria. This material can be detected even after the yolk deposition and may constitute the ovocyte germ plasm.
|
2022-12-30T00:13:23.509Z
|
208,239,050 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1177/028418515504400405",
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"status": null,
"url": null
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|
Many hypotheses have been suggested to explain the wellknown pro tective effect of sulfhydryl compounds against various forms of roentgen ray damage. This has been attributed to capture of radicals or oxidants formed during irradiation, reduction of the amount of oxygen available and hence the yield of certain of the oxidants, and protection or reactiva tion of sulfhydryl enzymes (PATT 1953). Protection by energy transfer (ALEXANDER and CHARLESBY 1954) and stimulation of regenerative mechanisms (CRONKITE et coll. 1951, BACQ et coll. 1953) have also been discussed. Some hypotheses thus suggest an association between the action of SH-compounds and the concentration of oxygen. One may attempt to clarify this question by observing whether or not these com pounds have any protective effect when irradiation is carried out under conditions characterised by a complete lack of oxygen. HOLLAENDER et coll. (1951) found that sulfhydryl compounds gave some protection to bacteria in an oxygen-free phosphate buffer. Irradia tion experiments on root tips of Allium cepa under conditions of anoxia (FORSSBERG and NYBOM 1953) suggested at most a slight additive effect produced by cysteine. PATT et coll. (1952), irradiating suspensions of rabbit thymic cells, found that removal of oxygen and presence of cysteine were not additive.
|
2022-01-27T07:43:32.391Z
|
7,933,899 |
{
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"ArXiv": null,
"DOI": "10.4269/ajtmh.16-0248",
"MAG": "2473655394",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc5014276?pdf=render"
}
|
In Waorani communities of the Amazon basin of Ecuador, hepatitis B (HB) surface antigen was found in 14% of asymptomatic persons. The aim of this study was to identify the Waorani population in Ecuador and obtain an epidemiologically adequate coverage of vaccination against hepatitis B virus (HBV) among them. Between February and September 2010, three vaccination campaigns were completed as part of a collaborative activity between the Ecuadorian Ministry of Public Health and the community leaders in the intervention areas. In addition, in 10 of the 22 Waorani communities, during first contact, a questionnaire about risk factors for HBV infection was administered. A total of 16 Waorani communities were registered before the beginning of this intervention, but during the actual process, six additional communities were identified. In total, 1,251 community members were registered, 92.7% of which received all three doses of the vaccine. Among them, 83% of survey respondents reported having been vaccinated, but only 22% were able to show proof. Only 1% of respondents were intravenous drug users, whereas 22% had at least one tattoo. All self-identified as heterosexual, but only 32% reported using condoms during sexual intercourse. By March 2015, no new cases of HB were been reported in any of the Waorani communities. Herein, we report the importance of intersectoral collaboration to strengthen health interventions in an isolated population like the Waorani area.
|
2022-08-31T10:42:25.813Z
|
184,038,892 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22201/ENEO.23958421E.2006.1.381",
"MAG": "2408355526",
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"license": null,
"status": null,
"url": null
}
|
A partir de la lectura de documentos oficiales, se reflexiona sobre los cambios que ha presentado el Estado mexicano, para asumirse actualmente como un estado evaluador; la participacion de la Organizacion de Cooperacion para el Desarrollo Economico (OCDE), en el diagnostico sobre la educacion en Mexico, y la aplicacion del Programa Internacional de Evaluacion de Estudiantes (PISA), sus resultados y la respuesta que da el gobierno en la generacion de estrategias para cambiar aptitudes de lectura de la poblacion mexicana. Se presentan resultados de una encuesta aplicada en el 2005, por la Procuraduria Federal del Consumidor (Profeco), para identificar como, a ocho anos del diagnostico de la OCDE (1997) Y a cinco de la aplicacion del PISA (2000), con enfasis en la lectura, la poblacion sigue presentando resultados negativos. La propuesta es ya no esperar politicas publicas, ante esta necesidad urgente, adoptar una actitud reflexiva y responsable con nosotros mismos y la poblacion con la que nos relacionamos, ya sea por razones laborales o familiares; con la certidumbre de que somos capaces de construir mejores mananas.
|
2022-09-16T03:16:02.770Z
|
13,151,299 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/heartjnl-2016-310529",
"MAG": "2579233076",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://heart.bmj.com/content/heartjnl/103/7/483.full.pdf"
}
|
Objective There is an international trend towards recommending medication to prevent cardiovascular disease (CVD) in individuals at increasingly lower cardiovascular risk. We assessed the cost-effectiveness of a population approach with a polypill including a statin (simvastatin 20 mg) and three antihypertensive agents (amlodipine 2.5 mg, losartan 25 mg and hydrochlorothiazide 12.5 mg) and periodic risk assessment with different risk thresholds. Methods We developed a microsimulation model for lifetime predictions of CVD events, diabetes, and death in 259 146 asymptomatic UK Biobank participants aged 40–69 years. We assessed incremental costs and quality-adjusted life-years (QALYs) for polypill scenarios with the same combination of agents and doses but differing for starting age, and periodic risk assessment with 10-year CVD risk thresholds of 10% and 20%. Results Restrictive risk assessment, in which statins and antihypertensives were prescribed when risk exceeded 20%, was the optimal strategy gaining 123 QALYs (95% credible interval (CI) −173 to 387) per 10 000 individuals at an extra cost of £1.45 million (95% CI 0.89 to 1.94) as compared with current practice. Although less restrictive risk assessment and polypill scenarios prevented more CVD events and attained larger survival gains, these benefits were offset by the additional costs and disutility of daily medication use. Lowering the risk threshold for prescription of statins to 10% was economically unattractive, costing £40 000 per QALY gained. Starting the polypill from age 60 onwards became the most cost-effective scenario when annual drug prices were reduced below £240. All polypill scenarios would save costs at prices below £50. Conclusions Periodic risk assessment using lower risk thresholds is unlikely to be cost-effective. The polypill would become cost-effective if drug prices were reduced.
|
2022-12-11T03:22:02.807Z
|
202,226,256 |
{
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"ArXiv": null,
"DOI": "10.1061/(ASCE)MT.1943-5533.0002904",
"MAG": "2969424026",
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}
|
AbstractTo obtain a waterproof binding material for bridge decks with properties of high bonding strength at high temperatures and high flexibility at low temperatures, a waterborne epoxy resin–pol...
|
2022-12-16T10:15:24.531Z
|
3,360,855 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1080/14760584.2017.1276831",
"MAG": "2562767599",
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},
"license": null,
"status": "CLOSED",
"url": null
}
|
Developed by Sanofi Pasteur, a tetravalent dengue vaccine, Dengvaxia, was recently recommended by the World Health Organization (WHO) Strategic Advisory Group of Experts (SAGE) on Immunization, bas...
|
2022-12-30T01:08:02.564Z
|
3,811,239 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CIS.2016.0071",
"MAG": "2577595939",
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"license": null,
"status": null,
"url": null
}
|
Nowadays email clients which support encryption and signature are mostly based on PKI system. The troubles introduced by the certificates bring a lot of inconvenience to users. Identity based encryption (IBE) is an asymmetric cryptographic algorithm that uses a user's unique identity as the public key, so that the troubles of exchanging and distributing public keys are avoided. However, the present standard applications do not support the IBE algorithm. To address this issue, we come up with the pseudo RSA digital certificate technology, which stores an IBE key in the RSA key structure of a certificate, and put forward a scheme of using an IBE plug-in component to implement the IBE functionality for the Outlook and Thunderbird.
|
2022-07-01T02:02:45.122Z
|
38,912,349 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1126/SCIENCE.7209550",
"MAG": "2000423253",
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},
"license": null,
"status": null,
"url": null
}
|
Large granulomas (greater than 2 millimeters in diameter), stimulated by the presence of and formed around necrotic larval tissue in the inner demibranchs of Corbicula fluminea, are eliminated by autotomy. Granulocytes invade and destroy ctenidial epithelium adjacent to the granuloma, causing it and the granuloma to slough away into the mantle cavity, where they are removed as pseudofeces.
|
2022-11-06T18:24:40.569Z
|
40,037,986 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PS.2007.4300726",
"MAG": "2797001516",
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},
"license": null,
"status": null,
"url": null
}
|
A multi-service optical packet ring for the metro area are presented in this paper. Cascadability issues through theoretical analysis and experimental investigations indicate that an optical packet technology could be a competitive solution for the next generation of metro networks.
|
2022-12-12T12:47:19.560Z
|
46,739,950 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000187981",
"MAG": "2042957703",
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},
"license": null,
"status": null,
"url": null
}
|
In 16 patients (9 on azathioprine, 7 not) the ineffective iron turnover (IIT) was much higher in the azathioprine group (62.7 +/- 6.7 vs. 23.5 +/- 3.5 mumol/l blood/day, p < 0.0001, 2-tailed t test), though the red cell iron turnover (RCIT) was similar (42.8 +/- 2.9 vs. 41 +/- 4.8). Erythropoietin improved the anaemia in all patients and raised the RCIT (4 still on azathioprine to 72.2 +/- 9.8, p < 0.003; 7 non-azathioprine patients to 62.7 +/- 5.3, p < 0.01); the IIT remained higher in the azathioprine-treated (85.5 +/- 19.3 vs. 37.1 +/- 5.4; p < 0.013). In 2 patients who discontinued azathioprine, the IIT declined markedly to normal. In summary, azathioprine exacerbates the anaemia of renal failure by augmenting ineffective erythropoiesis, while erythropoietin benefits those on azathioprine as much as other renal patients by stimulating both effective and ineffective erythropoiesis.
|
2022-12-16T05:10:50.934Z
|
13,784,612 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1532-5415.2008.02152.x",
"MAG": "2148120707",
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},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc2736556?pdf=render"
}
|
OBJECTIVES: To evaluate shared and unique risk factors for maintaining physical and cognitive function into the ninth decade and beyond.
|
2022-12-28T17:51:59.561Z
|
90,731,862 |
{
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"ArXiv": null,
"DOI": "10.1071/FP16283",
"MAG": "2600272740",
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"url": null
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|
Long-distance communications in giant characean internodal cells involve cytoplasmic streaming as an effective means for transportation of regulatory substances. The local illumination of Chara corallina Klein ex C.L.Willdenow internodal cells with an intense 30s pulse of white light caused a transient increase of modulated chlorophyll fluorescence in cell regions positioned downstream the cytoplasmic flow after a delay whose duration increased with the axial distance from the light source. No changes in fluorescence were observed in cell regions residing upstream of the light spot. The transient increase in actual fluorescence F' in cell areas exposed to constant dim illumination at large distances from the brightly lit area indicates the transmission of photosynthetically active metabolite between chloroplasts separated by 1-5mm distances. The shapes of fluorescence transients were sensitive to retardation of cytoplasmic streaming by cytochalasin D and to variations in cyclosis velocity during gradual recovery of streaming after an instant arrest of cyclosis by elicitation of the action potential. Furthermore, the analysed fluorescence transients were skewed on the ascending or descending fronts depending on the position of light-modulated cytoplasmic package at the moment of streaming cessation with respect to the point of measurements. The observations are simulated in qualitative terms with a simplified streaming-diffusion model.
|
2022-12-29T21:56:05.271Z
|
169,020,097 |
{
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"DOI": "10.1177/002252668400500115",
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|
live, labour, die or are cruelly maimed before our eyes. They inhabit moving shanty towns, drink unconscionable quantities of beer, terrorise local people, fight each other, yet contrive to move unbelievable amounts of earth; they are manipulated by contractors, swindled by trucksters, preached at by evangelists and killed or injured by work of unremitting danger and brutality. Dick Sullivan surveys the whole gamut of navvy activity from the canals of Brindley to the many massive reservoir schemes of the late nineteenth and early twentieth centuries. Although living conditions in the more settled encampments near docks or dams were marginally better than those encountered on canal and railway works, the toil remained brutalising and the atmosphere violent. To the very end the navvy was a social outcast who impinged on the locality in which he temporarily lived only as a threat to law and order, or as an opportunity for shameless exploitation by unscrupulous tradesmen. Parliament's interest in his moral and economic state was fitful. Unionisation was eventually achieved, but it never embraced more than the tiniest minority of navvies. More effective, probably, was the Navvy Mission Society, led by the formidable but thoroughly unpatronising Mrs Garnett. The Yorkshire-born widow of an Anglican priest (he died on their honeymoon), Elizabeth Garnett laboured some fifty years trying, with her fierce love, to civilise and christianise her fellow navvies, as she called them. If the religious message took little noticeable root, the many incidentals of concern, not least her quarterly magazine with its news of jobs, missing comrades and lost husbands, represented the only alleviation of the navvy's isolation. This is emphatically not an academic book in the usual sense of the term. It uses few statistics, avoids sophisticated class analysis and is richly anecdotal. It is, however, based on deep research and understanding. Its apparent weakness (from the academic viewpoint) is its real strength. Dick Sullivan makes his theme live in a way which few dons could have done. He writes extremely well, with many a telling image or memorable expression and with a keen insight into a harsh and raw world. He interThe Journal of Transport History
|
2022-02-08T18:02:36.783Z
|
76,475,042 |
{
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"DOI": "10.20453/RNP.V68I3-4.1591",
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"url": null
}
|
Resultados. 67 MGs (93%) reportaron haber diagnosticado pacientes con depresion y 56 (84%) reportaron empezarles tratamiento farmacologico. Los MGs listaron como quejas frecuentes de presentacion: dificultad para realizar labores habituales (21%), tristeza (15%), cefalea/dolor cervical (11%), ansiedad (8%), artralgias (6%) y sintomas gastrointestinales (2%). El numero de sintomas listado por los MGs como utiles para hacer el diagnostico de depresion, fue en promedio 5.15 (DE=1.66) y el numero de sintomas necesario para empezar tratamiento fue 3.3 (DE=1.02). El promedio de sintomas correctos fue 3.18 (DE=1.24), segun DSM-IV y 3.29 (DE=1.30), segun CIE-10 (menor al numero de criterios de sistemas de clasificacion estandar). Los psicotropicos mas frecuentemente indicados fueron fluoxetina (45%) y amitriptilina (21%). Un 86% de los MGs reportaron informar al paciente sobre la duracion del tratamiento, 73% sobre sus potenciales efectos secundarios y 96% reporta citarlos para seguimiento.
|
2022-04-01T00:22:28.684Z
|
67,014,867 |
{
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"ArXiv": null,
"DOI": "10.1117/12.2310101",
"MAG": "2802194317",
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"license": null,
"status": null,
"url": null
}
|
This paper aims to study the problem of multi-class object detection in video stream with Viola-Jones cascades. An adaptive algorithm for selecting Viola-Jones cascade based on greedy choice strategy in solution of the N-armed bandit problem is proposed. The efficiency of the algorithm on the problem of detection and recognition of the bank card logos in the video stream is shown. The proposed algorithm can be effectively used in documents localization and identification, recognition of road scene elements, localization and tracking of the lengthy objects , and for solving other problems of rigid object detection in a heterogeneous data flows. The computational efficiency of the algorithm makes it possible to use it both on personal computers and on mobile devices based on processors with low power consumption.
|
2022-09-06T19:22:18.367Z
|
39,171,168 |
{
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"DOI": "10.1111/J.0954-6820.1981.TB09798.X",
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|
The results of 160 consecutive fibre-optic endoscopic polypectomies in the gastrointestinal tract are reviewed. Of 22 polyps snared in the upper digestive tract, 16 could be retrieved. One gastric polyp showed early intramucosal carcinoma. Biopsies from a pedunculated duodenal polyp, which was lost after snaring, revealed adenoma with moderate atypia. Of 138 resected colonic polyps, 132 were retrieved. Of these, 104 (79%) were adenomas. Of 49 colonic adenomas smaller than 10 mm, 4 (8%) showed severe atypia (carcinoma in situ) but not invasive carcinoma. Of 36 adenomas sized 10--19 mm 8 (22%) showed severe atypia and one (3%) invasive carcinoma. Of 19 adenomas larger than 60 mm, 6 (32%) showed severe atypia and one (5%) invasive carcinoma. Of the colonic polyp patients, 87% had only one or two polyps. Synchronous adenomas and non-neoplastic polyps were found in 6 of 11 cases with 3 or more colonic polyps. It is concluded that endoscopic polypectomy, carefully and properly performed, is a valuable and promising procedure in the diagnosis and treatment of polyps in the gastrointestinal tract, especially in the large bowel.
|
2022-09-15T06:16:29.031Z
|
153,805,856 |
{
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"ArXiv": null,
"DOI": "10.1177/0266242609339333",
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}
|
Book Review : Prashantham Shameen, The Internationalization of Small Firms: A Strategic Entrepreneurship Perspective
|
2022-11-17T19:00:47.202Z
|
7,042,827 |
{
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"DOI": "10.1109/TPAMI.2015.2430342",
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"url": null
}
|
The skeleton of a 2D shape is an important geometric structure in pattern analysis and computer vision. In this paper we study the skeleton of a 2D shape in a two-manifold <inline-formula><tex-math>$\mathcal {M}$</tex-math> <alternatives><inline-graphic xlink:type="simple" xlink:href="liu-ieq1-2430342.gif"/></alternatives></inline-formula>, based on a geodesic metric. We present a formal definition of the skeleton <inline-formula><tex-math>$S(\Omega )$</tex-math><alternatives> <inline-graphic xlink:type="simple" xlink:href="liu-ieq2-2430342.gif"/></alternatives></inline-formula> for a shape <inline-formula> <tex-math>$\Omega$</tex-math><alternatives><inline-graphic xlink:type="simple" xlink:href="liu-ieq3-2430342.gif"/></alternatives> </inline-formula> in <inline-formula><tex-math>$\mathcal {M}$</tex-math><alternatives> <inline-graphic xlink:type="simple" xlink:href="liu-ieq4-2430342.gif"/></alternatives></inline-formula> and show several properties that make <inline-formula><tex-math>$S(\Omega )$</tex-math><alternatives><inline-graphic xlink:type="simple" xlink:href="liu-ieq5-2430342.gif"/> </alternatives></inline-formula> distinct from its Euclidean counterpart in <inline-formula><tex-math>$\mathbb {R}^2$ </tex-math><alternatives><inline-graphic xlink:type="simple" xlink:href="liu-ieq6-2430342.gif"/></alternatives></inline-formula>. We further prove that for a shape sequence <inline-formula><tex-math>$\lbrace \Omega _i\rbrace$</tex-math><alternatives> <inline-graphic xlink:type="simple" xlink:href="liu-ieq7-2430342.gif"/></alternatives></inline-formula> that converge to a shape <inline-formula><tex-math>$\Omega$</tex-math><alternatives><inline-graphic xlink:type="simple" xlink:href="liu-ieq8-2430342.gif"/> </alternatives></inline-formula> in <inline-formula><tex-math>$\mathcal {M}$</tex-math><alternatives> <inline-graphic xlink:type="simple" xlink:href="liu-ieq9-2430342.gif"/></alternatives></inline-formula>, the mapping <inline-formula> <tex-math>$\Omega \rightarrow \overline{S}(\Omega )$</tex-math><alternatives> <inline-graphic xlink:type="simple" xlink:href="liu-ieq10-2430342.gif"/></alternatives></inline-formula> is lower semi-continuous. A direct application of this result is that we can use a set <inline-formula><tex-math>$P$</tex-math><alternatives> <inline-graphic xlink:type="simple" xlink:href="liu-ieq11-2430342.gif"/></alternatives></inline-formula> of sample points to approximate the boundary of a 2D shape <inline-formula><tex-math>$\Omega$</tex-math><alternatives> <inline-graphic xlink:type="simple" xlink:href="liu-ieq12-2430342.gif"/></alternatives></inline-formula> in <inline-formula><tex-math> $\mathcal {M}$</tex-math><alternatives><inline-graphic xlink:type="simple" xlink:href="liu-ieq13-2430342.gif"/></alternatives> </inline-formula>, and the Voronoi diagram of <inline-formula><tex-math>$P$</tex-math><alternatives> <inline-graphic xlink:type="simple" xlink:href="liu-ieq14-2430342.gif"/></alternatives></inline-formula> inside <inline-formula><tex-math> $\Omega \subset \mathcal {M}$</tex-math><alternatives><inline-graphic xlink:type="simple" xlink:href="liu-ieq15-2430342.gif"/> </alternatives></inline-formula> gives a good approximation to the skeleton <inline-formula><tex-math>$S(\Omega )$ </tex-math><alternatives><inline-graphic xlink:type="simple" xlink:href="liu-ieq16-2430342.gif"/></alternatives></inline-formula>. Examples of skeleton computation in topography and brain morphometry are illustrated.
|
2022-12-19T05:08:47.495Z
|
137,924,842 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1061/(ASCE)MT.1943-5533.0001731",
"MAG": "2517206422",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
AbstractThis study evaluates the impact resistance and mechanical properties of a number of developed self-consolidating rubberized concrete (SCRC) mixtures reinforced with steel fibers (SFs). In this research, SFs were used to compensate for the reduction in tensile and flexural strength that resulted from adding high volumes of crumb rubber (CR). SFs were also used to exploit the beneficial interaction between SFs and CR to develop low-density concrete with higher impact resistance. The experimental variables were different replacement levels of fine aggregate volume by CR (0–40%), binder content (550–600 kg/m3), SF volume fractions (0, 0.35, 0.5, 0.75, and 1%), and size of SFs. Tests included fresh properties, compressive strength, splitting tensile strength (STS), flexural strength (FS), and impact loading (drop-weight on cylindrical specimens and flexural impact loading on small-scale beams). The results indicated that adding CR to concrete improved the impact energy absorption and ductility, wherea...
|
2023-01-01T20:50:46.977Z
|
194,038,879 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00837792.1965.10669812",
"MAG": "2048266679",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
SUMMARY The history of MICHELI'S illustration called « Marsilea terrestris, minima, angustifolia, nigricans, flore bipartito » (incidentally the type of Blandowia michelii Corda in modern nomenclature) is traced through an engraving by PETIVEE and a series of notebook illustrations by TOZZI. These illustrations are believed to have had their foundation in a specimen of Utricularia. The other half of the Italian podostem legend, the report by CORDA from Lombardia of an undoubted member of the Podostemaceae, now Blandowia preissii (Tulasne) Weddell, still awaits a satisfactory explanation.
|
2022-02-08T08:17:27.839Z
|
204,262,164 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14681/AFKIT.2016.003",
"MAG": "2975180457",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
STRESZCZENIE: Artykuł prezentuje trendy panujące w nieinwazyjnym monitorowaniu wałów przeciwpowodziowych z wykorzystaniem różnorodnych technologii fotogrametrycznych i teledetekcyjnych pozyskujących dane z różnego pułapu lotniczego. Na tym tle zaprezentowano projekt SAFEDAM, którego celem jest stworzenie systemu monitorującego wały przeciwpowodziowe z użyciem nieinwazyjnej, latającej bezzałogowej platformy pomiarowej skanującej z niskiego pułapu lotu i wykorzystaniu zobrazowań lotniczych i satelitarnych. System będzie wykorzystywał wieloźródłowe dane fotogrametryczne. SAFEDAM umożliwi wykorzystanie z pułapu satelitarnego zarówno danych optycznych (z zakresu światła widzialnego i bliskiej podczerwieni) jak i danych radarowych. W odniesieniu do technik lotniczych wykorzystanie mają dane fotogrametryczne z pzgik zasobu jak i dane pozyskane z platformy BSP (UAV) dedykowanej projektowi SAFEDAM. Wśród danych niskopułapowych wykorzystane są dane z lekkiego skanera lotniczego, obrazowe dane wielospektralne, a także dane termalne. Wieloźródłowe dane pozwalają na przeprowadzenie oceny stan wałów przeciwpowodziowych, jak również umożliwić będą wykrycie ewentualnych zmian, które mogą zaistnieć zarówno w prewencyjnej jak i interwencyjnej konfiguracji systemu. W założeniach system umożliwiać będzie ekspercką ocenę wałów przeciwpowodziowych, która potrzebna jest w pracy specjalistów od zarządzania infrastrukturą przeciwpowodziową, a także organom bezpieczeństwa kryzysowego. Kompleksowy system IT będzie gromadził dane i automatycznie je analizował i wizualizował dostarczając informacji o stanie zagrożenia dla służb hydrologicznych i specjalistów zarządzania kryzysowego. Całość systemu będzie uzupełnieniem dotychczasowych projektów ochrony przeciwpowodziowej kraju (np. ISOK). Projekt SAFEDAM realizujący te założenia finansowany jest ze środków Narodowego Centrum Badania i Rozwoju w programie Bezpieczeństwo i Obronność
|
2022-07-25T16:15:08.136Z
|
202,818,976 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/dat-04-2019-0012",
"MAG": "2971856073",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152372"
}
|
Purpose
The purpose of this paper is to explore the various ways users of synthetic cannabinoids (SCs) managed the dangers associated with the consumption of this substance.
Design/methodology/approach
This paper is based on a parent study of the use and market of synthetic cathinones (also known as “bath salts”) in New York City, Houston, Galveston and New Orleans. Focus groups were conducted in all four cities with a total of 20 individuals who identified as users of SCs. Grounded theory was used to analyse focus group transcripts.
Findings
Participants were aware of drug-related risks and implemented strategies to reduce harm to health. Protective measures fell into two broad categories: marketing and consumption. They noted the instability of SC products and consumer manipulation through packaging. Harm reduction (HR) strategies included: carefully selecting SC sources; sticking to one brand; handling their own SC; managing amount of K2 consumed in one sitting; controlling the pace.
Originality/value
Given the small amount of data on user experience with SCs and its risk to health, it is important to learn from users themselves how they create methods to keep themselves safe. This is one of the first studies recording HR practices of SC users and can contribute to intervention programs and organisations serving substance users.
|
2022-08-19T16:34:31.148Z
|
22,166,566 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0022029900023931",
"MAG": "2134163364",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
SUMMARY The caseinolytic activities at pH 6·8 of polymorphonuclear (PMN) and mononuclear leucocyte homogenates (equivalent to a level of 106 cells/ml milk) were less than the levels of natural milk proteinase activity found in milk from healthy cows. Bulk milks contained ∼ 4 times more milk proteinase activity than the composite milks from individual healthy cows. Isolated blood leucocytes, when added to raw milk of good bacteriological quality and stored at 5 °C, did not readily degenerate and had no detectable effect on the milk proteins even when these cells were completely disrupted by homogenization of the milk. Pasteurization of milk which contained leucocytes caused loss of cell vitality. Extracellular proteinases of psychrotrophic bacteria growing in milk were not detected until the early stationary phase of growth. The total viable count at which this occurred varied greatly. Proteinase production by a pure culture of Pseudomonas fluorescens was not detected in milk stored at 5 °C until a viable count of ∼ 109 colony forming units (c.f.u.)/ml was obtained, whilst normal bulk milks stored at 5 °C produced detectable levels of extracellular proteinase(s) when the psychrotrophic flora reached 107–108 c.f.u./ml. Casein proteolysis by PMN and mononuclear leucocyte homogenates resulted in similar polypeptide maps, but plasmin and bacterial proteinase isolated from a strain of Serratia marcescens resulted in polypeptide maps different from each other and from that produced by the leucocyte proteinase(s). The rate of proteolysis of caseins by the different proteinase sources appeared to be in the order αsl- > β- > > κ-casein for the leucocyte extracts, β- > αsl- > > > κ-casein for bovine plasmin and β- ≈ κ- > αsl-casein for S. marcescens proteinase.
|
2022-09-14T04:24:50.286Z
|
101,266,292 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/S-2003-39408",
"MAG": "2266716642",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
High-intensity ultrasounds have been employed in the synthesis of 4-hydroxycoumarin derivatives, using mainly water as reaction medium. Marked improvements of reaction rates, chemoselectivity and product yields have been observed on comparing sonochemical with ordinary conditions. In the alkylation of a series of allyl and benzyl bromides a pathway switch occured to yield 3-alkyl-4-hydroxycoumarin derivatives.
|
2022-09-14T23:33:27.032Z
|
21,419,474 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4161/cc.6.20.4817",
"MAG": "2032523558",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Cytokinesis requires proper regulation of microtubule dynamics. It has been suggested that dynamic astral microtubules prevent cortical ingression. However, it remains unknown how astral microtubules maintain their dynamic state. Here we show that aurora B kinase, a component of the chromosome passenger complex, is required to sustain the dynamic state of astral microtubules during cytokinesis. Treatment of HeLa cells with Hesperadin, an inhibitor of aurora B kinase, caused abnormal cortical protrusion, leading to cortical ingression in the protruding region and cytokinesis failure. Actin filaments, myosin II, and RhoA failed to localize at the equator but instead distributed along the lateral and/or polar cortex in cells treated with Hesperadin. Time-lapse analyses of microtubule dynamics showed that, in cells treated with Hesperadin, abnormally bundled astral microtubules targeted the protruding region. Mitotic kinesin-like protein 1 (MKLP1), a component of the spindle midzone required for bundling of microtubules, was not detected along bundled astral microtubules in cells treated with Hesperadin, suggesting that factors other than MKLP1 may be involved in this process. Our results suggest that aurora B kinase activity is required for proper regulation of microtubule dynamics to ensure that cytokinesis occurs precisely at the cell equator.
|
2022-12-10T09:39:07.285Z
|
93,523,517 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.1678120",
"MAG": "1985921166",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The free radicals produced in frozen, polycrystalline AsF3 and AsCl3 by γ irradiation have been characterized by ESR and shown to be AsF3− and, most probably, AsCl3−. Hyperfine interactions with arsenic are observed in each case and in AsF3−, ligand hyperfine splittings by three fluorine atoms, two of one kind and one of another, are also seen. The ESR parameters are consistent with an approximately planar‐T configuration for AsF3− with the odd electron largely in an orbital perpendicular to the plane.
|
2022-09-08T13:15:37.555Z
|
239,642,476 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5281/ZENODO.5199851",
"MAG": "3197323309",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The paper reflects on a review and description of the theoretical corpus of the field of human rights problems and an analysis of the productions of meaning originated from the pandemic crisis scenario. Human rights are understood as a field of interdisciplinary problems that stem from struggles and conquests developed throughout history. They possess a theoretical-conceptual and empirical-methodological accumulation that dialogues from different fields of action. However, the expression human rights is relatively recent in the history of humanity, even though concepts related to freedom, justice and human dignity have been proclaimed and defended throughout history.
|
2022-02-07T20:19:44.272Z
|
234,967,636 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5281/ZENODO.4400278",
"MAG": "3118310111",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, an inscription with 12 lines on a sarcophagus found at south nekropolis of Andriake in 2009 is presented. According to the inscription, the tomb owners are Konon II of Myra and his wives, Ptolemaïs of Myra, daughter of Demetrios, and Arsasis of Myra, daughter of Lysimakhos. The fine is expressed in kitarephoros and the sarcophagus type indicate that the inscription dates from I. cent. A.D.
|
2022-02-07T21:28:49.774Z
|
147,296,645 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17977/JIP.V10I1.110",
"MAG": "2286331149",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Institutiometric model is designed to support the education institution in optimizing its resource management, and its resource development.The number of enrollment, the number of student body, the number of graduates, the budget, and the lecturers are the proxy variables for the education resources. These basic variables are processed to become index variables, created variables, and attained variables. These variables are used to build an institutiometric model, based on a Markov chain model, as a predictive model for the educational planning. It is expected that this model can be applied for the educational planning in both private and state higher education institu-tions, or in other educational institutions.
|
2022-02-09T05:29:22.010Z
|
62,729,093 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/EB023408",
"MAG": "2081860037",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Describes the recovery movement collection in the General Research Division of the New York Public Library. States that although these materials are purchased for their future research value, they are frequently requested by library users. Lists the contents of the recovery movement collection.
|
2022-02-11T14:27:44.396Z
|
116,053,741 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/SENSORS.2017.SEW3E.5",
"MAG": "2801962632",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We demonstrate an ultra-thin planar perfect absorber based on the excitation of a topologically-protected interfacial optical state and test its performance as a sensitive optical sensor in both the amplitude and phase detection schemes.
|
2022-07-04T22:22:12.186Z
|
248,021,283 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/magnetochemistry8040040",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2312-7481/8/4/40/pdf?version=1649232236"
}
|
: The corrosion of metals is a major problem of modern societies, demanding new technologies and studies to understand and minimize it. Here we evaluated the effect of a magnetic field ( B ) on the corrosion of copper in aqueous HCl solution under open circuit potential. The corrosion product, Cu 2+ , is a paramagnetic ion and its concentration in the solution was determined in real time in the corrosion cell by time-domain NMR relaxometry. The results show that the magnetic field ( B = 0.23 T) of the time-domain NMR instrument reduces the corrosion rate by almost 50%, in comparison to when the corrosion reaction is performed in the absence of B . Atomic force microscopy and X-ray diffraction results of the analysis of the corroded surfaces reveal a detectable CuCl phase and an altered morphology when B is present. The protective effect of B was explained by magnetic forces that maintain the Cu 2+ in the solution/metal interface for a longer time, hindering the arrival of the new corrosive agents, and leading to the formation of a CuCl phase, which may contribute to the rougher surface. The time-domain NMR method proved to be useful to study the effect of B in the corrosion of other metals or other corrosive liquid media when the reactions produce or consume paramagnetic ions.
|
2022-10-07T00:19:25.395Z
|
24,740,309 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7196/SAMJ.2016.v106i4.9758",
"MAG": "2332898103",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Haematological changes associated with malaria are well recognised, but may vary with level of malaria endemicity and patient background, haemoglobinopathy, nutritional status, demographic factors and malaria immunity. Although malaria in South Africa (SA) has been reduced dramatically in endemic areas, little is known about the haematological changes associated with malaria infection among refugee populations who live in SA cities.
OBJECTIVE
To describe haematological alterations among malaria-infected refugees living in Durban, SA.
METHODS
A cross-sectional study was conducted from September 2012 to July 2013 inclusive at a refugee centre in central Durban. Blood samples from 102 adult black African refugees were examined for infection with malaria parasites, and haematological profiles were compared with standard normal values.
RESULTS
Malaria infection was detected in 16 (15.7%) of the 102 participants. The mean haemoglobin (Hb) value was reduced (mean 9.2 g/dL) in the participants with malaria, who also had an extremely low mean packed cell volume (PCV) of 28.3%. The mean Hb value in the non-malaria-infected participants was normal (12.6 g/dL), and the mean PCV was slightly low (38.0%).
CONCLUSIONS
Anaemia was more common among participants with malaria infection than among those who were uninfected. Other haematological changes were common in both infected and uninfected participants, suggesting that infections other than malaria, or other underlying factors that cause haematological alterations, may be present. This research needs to be expanded to include a large sample and other areas and infections.
|
2022-08-24T03:46:16.262Z
|
73,463,615 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acsami.8b21803",
"MAG": "2916536955",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Self-assembled Ni(OH)2 nanosheet-decorated hierarchical flower-like MnCo2O4.5 nanoneedles were synthesized via a cost-effective and facile hydrothermal strategy, aiming to realize a high-capacity advanced electrode of a battery-supercapacitor hybrid (BSH) device. It is demonstrated that the as-synthesized hierarchical flower-like MnCo2O4.5@Ni(OH)2-nanosheet electrode exhibits a high specific capacity of 318 mAh g-1 at a current density of 3 A g-1 and still maintains a capacity of 263.5 mAh g-1 at a higher current density of 20 A g-1, with an extremely long cycle lifespan of 87.7% capacity retention after 5000 cycles. Moreover, using the unique core-shell structure as the cathode and hollow Fe2O3 nanoparticles/reduced graphene oxide as the anode, the BSH device delivers a high energy density of 56.53 Wh kg-1 when the power density reaches 1.9 kW kg-1, and there is an extraordinarily good cycling stability with the capacity retention rate of 90.4% after 3000 cycles. It is believed that the superior properties originate from desirable core-shell structures alleviating the impact of volume changes as well as the existence of two-dimensional Ni(OH)2 nanosheets with more active sites, thereby improving the cycle stability and achieving ultrahigh capacity. These results will provide more access to the rational material design of diverse nanostructures toward high-performance energy storage devices.
|
2022-12-10T11:26:49.636Z
|
218,465,938 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/s0365-05962011000400025",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "http://www.scielo.br/pdf/abd/v86n4/en_v86n4a25.pdf"
}
|
Inverted Schneiderian papilloma (ISP) is a neoplasm of epithelial lining origin which arises in the respiratory mucosa that lines the nasal cavity and paranasal sinuses. The inverted Schneiderian papilloma frequently appears as a unilateral lesion in the nasal septum and extends secondarily to the nasal and paranasal sinuses. This paper reports an unusual case of this pathology with involvement of the oral cavity in a 61-year-old white man. Clinical evaluation revealed a vegetating mass in the alveolar ridge of the right maxilla that had been present for approximately 4 months. After radiographic evaluation, involvement of the maxillary sinus was detected. Microscopic evaluation, in situ hybridization and immunohistochemical analysis of the specimen led to a diagnosis of ISP moderate dysplasia associated with HPV infection.
|
2022-12-16T15:45:21.931Z
|
207,594,624 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1535-7163.MCT-12-0654",
"MAG": "2119596897",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
LY2334737, an oral prodrug of gemcitabine, is cleaved in vivo, releasing gemcitabine and valproic acid. Oral dosing of mice results in absorption of intact prodrug with slow systemic hydrolysis yielding higher plasma levels of LY2334737 than gemcitabine and prolonged gemcitabine exposure. Antitumor activity was evaluated in human colon and lung tumor xenograft models. The dose response for efficacy was examined using 3 metronomic schedules, once-a-day dosing for 14 doses, every other day for 7 doses, and once a day for 7 doses, 7 days rest, followed by an additional 7 days of once-a-day dosing. These schedules gave significant antitumor activity and were well tolerated. Oral gavage of 6 mg/kg LY2334737 daily for 21 days gave equivalent activity to i.v. 240 mg/kg gemcitabine. HCl administered once a week for 3 weeks to mice bearing a patient mesothelioma tumor PXF 1118 or a non–small cell lung cancer tumor LXFE 937. The LXFE 397 tumor possessed elevated expression of the equilibrative nucleoside transporter-1 (ENT1) important for gemcitabine uptake but not prodrug uptake and responded significantly better to treatment with LY2334737 than gemcitabine (P ≤ 0.001). In 3 colon xenografts, antitumor activity of LY2334737 plus a maximally tolerated dose of capecitabine, an oral prodrug of 5-fluorouracil, was significantly greater than either monotherapy. During treatment, the expression of carboxylesterase 2 (CES2) and concentrative nucleoside transporter-3 was induced in HCT-116 tumors; both are needed for the activity of the prodrugs. Thus, metronomic oral low-dose LY2334737 is efficacious, well tolerated, and easily combined with capecitabine for improved efficacy. Elevated CES2 or ENT1 expression may enhance LY2334737 tumor response. Mol Cancer Ther; 12(4); 481–90. ©2013 AACR.
|
2022-12-19T22:30:40.952Z
|
221,486,095 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/pauz.19980270222",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Virtuelle Fachbibliothek Pharmazie ViFaPharm (UB Braunschweig) Arzneimittel im Fokus (AmFo) gemeinsame Informationsplattform der Kassenärztlichen Bundesvereinigung u. der Spitzenverbände der Krankenkassen Drugscope: External Site Links (Schwerpunkt: UK) auch Zugang zu Arneimitteldatenbanken Genomics: A Global Resource Institute for Safe Medication Practices (Hinweise auf Nebenwirkungen, Warnungen an Patienten u.a.) MedPharmGuide: Fulltext Search Engine For Pharmacology-related Internet Servers (Suchmaschine f. d. Life Sciences-Bereich) The Merck Manual of Diagnosis and Therapy (17th ed., Centennial Ed.) Pharm.Net.Bund DAS PORTAL FÜR ARZNEIMITTELINFORMATIONEN DES BUNDES UND DER LÄNDER Arzneimitteldatenbank Alphabetische Suche + Recherche nach Arzneimitteln myCARE OHG Wittenberg U.S. Food and Drug Administration (FDA)
|
2022-12-20T02:35:16.255Z
|
55,192,965 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14419/IJAES.V3I1.4549",
"MAG": "2010206762",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Voluntary disclosure and transparency can preserve the interests of shareholders, and the company's performance improves. in this paper, the importance of transparency in financial reporting and expressed its limitations and quality of disclosure and transparency, we express and at the end of the importance and benefits of voluntary disclosure, as well as major issues and the impact of voluntary disclosure of information in the market. we will examine.
|
2022-12-24T05:00:29.607Z
|
27,930,488 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/gut.31.3.334",
"MAG": "2018306494",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://gut.bmj.com/content/gutjnl/31/3/334.full.pdf"
}
|
This paper describes the results of transproctoscopic fine needle aspiration cytology in the diagnosis of rectal lesions. Fifty one consecutive patients referred with a presumptive diagnosis of rectal mass were subjected to proctoscopic examination when fine needle aspiration cytology, brush cytology and biopsy samples were taken. Of the 30 patients of malignancy of rectum in whom all the three sampling techniques were applied, the biopsy was positive in 27 (90%), brush cytology in 25 (83.3%) and fine needle aspiration cytology in 29 (96.6%). A combination of fine needle aspiration cytology with brush cytology gave a positive yield in 96.6% while that fine needle aspiration cytology with brush cytology gave a yield of 100%. Fine needle aspiration cytology was most helpful in infiltrative tumours. All 10 patients with secondaries in the pouch of Douglas or rectovesical pouch, and the single patient with submucosal rectal carcinoma were correctly diagnosed at fine needle aspiration cytology. There were no false positive results with fine needle aspiration cytology and no complications were encountered with the procedure.
|
2022-12-30T00:44:34.015Z
|
130,833,938 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1061/9780784413692.138",
"MAG": "2317714523",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
On July 1, 2013, a wildfire was started by a lightning strike in the Spring Mountains, located west of Las Vegas, Nevada. Two small water systems were affected by the fire, Trout Canyon and Kyle Canyon. The fire burned more than 27,800 acres and by July 15, 2013 the fire was 70% contained, allowing the evacuated residents to return to their homes. The fire was not 100% contained until September 17, 2013. The NvWARN system was activated to repair the Trout Canyon Water System utilizing materials from water systems throughout Nevada and crews from the Las Vegas Valley Water District. Repairs, from the fire damage, on the Trout Canyon Water System were completed on August 30, 2013. Heavy rains over the Labor Day weekend, dating from August 30, 2013 to September 2, 2013, caused massive debris flows that completely destroyed the Trout Canyon Water System and damaged the Kyle Canyon Water System. This paper describes the damage that occurred to both the water systems and shows more damage to water systems can occur after a forest fire than during the actual fire event. This paper also discusses how emergency agreements that are in place will assist smaller communities, but the smaller communities still need emergency plans and funding sources before a disaster occurs. Finally, the paper contrasts the damage to an upgraded modern water system versus an older system, showing how the modern system withstood the storm with less damage.
|
2022-02-09T14:00:21.456Z
|
167,918,286 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/EUM0000000004891",
"MAG": "1982259509",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Investigates the images and preferences for six long‐haul “exotic” tourist destinations among a small random sample of prospective Finnish customers. Looks at the promotional problem and suggests further steps for continued research.
|
2022-02-08T18:41:35.464Z
|
24,780,782 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IEMBS.1992.5761650",
"MAG": "2011153464",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Research reported here is primarily concerned with the development and application of high speed/VLSi intelligent binary transducers, bioelectrodes to detect low qpressure and current changes. These biomolecular information processing elements (biosensors) can be directly installable devices in vocal organs and in some possible places of articultion to study the biomechanism of speech. These transducers allows the data acquisition facilities for parallel processing computers and knowledge based on intelligent speech recognition system.
|
2022-02-12T18:29:32.616Z
|
167,862,889 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/02522667.2008.10699854",
"MAG": "2006087445",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This research presents an optimal model to evaluation solar photovoltaic industry operation performance. The proposed model was applied the Balance Scorecard (BSC) model to construct a framework for solar photovoltaic industry. The BSC model is helps to define the hierarchy with five perspectives that are customer, financial, internal business process, learning and growth and risk. Next, the relative weights of evaluative criteria are then determined by using the analytical hierarchy process (AHP). Finally, followed by ranking of the photovoltaic industries operation performance can to assist decision makers evaluating in solar photovoltaic industry. BSC and AHP-based decision-making method for constructing evaluation methods, which can provide solar photovoltaic industry decision makers or investor with a valuable reference for evaluating the operation performance. Importantly, the proposed model can assist the administrators to assess the operation performance of solar photovoltaic industry, improving applicability for academic and commercial purposes.
|
2022-08-29T23:26:45.420Z
|
88,377,712 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/1484803",
"MAG": "2319014043",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Planktonic foraminifera collected in coastal waters off southern California were maintained in a healthy condition, floating in their containers with the support of elongate pseudopodia, for periods of up to three months. Simple techniques were used to culture these surprisingly hardy organisms. Collection and laboratory maintenance of living planktonic foraminifera
|
2022-09-07T06:14:44.289Z
|
125,227,489 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24033/MSMF.207",
"MAG": "2585690378",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
© Mémoires de la S. M. F., 1976, tous droits réservés. L’accès aux archives de la revue « Mémoires de la S. M. F. » (http:// smf.emath.fr/Publications/Memoires/Presentation.html) implique l’accord avec les conditions générales d’utilisation (http://www.numdam.org/legal.php). Toute utilisation commerciale ou impression systématique est constitutive d’une infraction pénale. Toute copie ou impression de ce fichier doit contenir la présente mention de copyright.
|
2022-09-17T07:55:48.430Z
|
253,261,935 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.57251/tem.v1i2.544",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "http://jurnal.medanresourcecenter.org/index.php/TEM/article/download/544/450"
}
|
The aims of this research are: (1) to find out how much the improvement in PLC operating competence of students in the TITL skill program at SMKN 2 Karang Baru through the use of a problem-based learning model with the help of the Zelio SR2B201BD PLC trainer learning media with traffic light applications seen from the learning outcomes of the affective domain; (2) to find out how much the improvement in PLC operating competence of the TIPTL skill program students of SMKN 2 Karang Baru through the use of problem-based learning models assisted by learning media for PLC trainer Zelio SR2B201BD with traffic light applications seen from the learning outcomes of the cognitive domain; (3) to find out how much the improvement in PLC operating competence of students in the TITL skill program at SMKN 2 Karang Baru through the use of a problem-based learning model assisted by learning media for the PLC trainer Zelio SR2B201BD with traffic light applications seen from the learning outcomes of the psychomotor domain. This research is a Classroom Action Research (CAR). The subjects of this study were students of class XII CI-BI Electrical Power Installation Engineering Expertise Program (TITL) SMKN 2 Karang Baru, totaling 26 people. The improvement of competence to be achieved is viewed from the three domains of student competence, namely; affective aspects, cognitive aspects and psychomotor aspects. The data on the students' affective and psychomotor aspects were collected using the observation sheet instrument for affective and psychomotor observations. Data on students' cognitive aspects were collected using a test instrument, which was given at the end of each cycle. The results of the research in the first cycle of student competence were still low, while in the second cycle it increased and reached the established indicators of success. The improvements are: 1) for the affective domain of 4.4, from 14.1 in the first cycle to 18.5 in the second cycle with a maximum score of 20 and getting a very good category, 2) for the cognitive domain of 8.64, from 75 .77 in the first cycle to 84.42 in the second cycle, 3) for the psychomotor domain of 25.68, from 57.63 in the first cycle to 83.31 in the second cycle.
|
2022-11-04T04:06:42.545Z
|
96,979,400 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2494/PHOTOPOLYMER.8.325",
"MAG": "2061021591",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Introduction Rigid-rod polyimides became important due to those low thermal expansion and electronic properties. However, most rigid-rod polyimides are insoluble and have some limit for applying widely. Recently, our laboratory found soluble rigid polyimides by introducing bulky substituents(1,2). Furthermore, we synthesize completely rigid rod polyimides from pyromellitic dianhydride derivatives and 2,2'-bis(trifluoromethyl)benzidine(3). Matsuura et al. synthesized 3,6-bis(trifluoromethyl)-pyromellitic dianhydride and those polyimides (4). These polyimides promise to have low thermal expansion and low dielectric constant which are desirable for electronic fields. The aromatic polyimides are formed between aromatic tetracarboxylic acid and aromatic diamine. The tetracarboxylic acid is a good electron acceptor due to its four carboxylic acid groups, and the diamine is a good electron donor. The polyimides form charge transfer complex between the tetracarboxylic acid moieties and the diamine moieties(5,6). Furthermore, an anion radical of tetra carboxylic acid moieties forms electro-chemically(7,8) in the polyimide film. In this paper, authors are synthesized a series of new rigid-rod polyimides based on substituted pyromellitic dianhydrides and observed a unique photo-induced charge separation in the soluble rigid rod polyimides in solution and extraordinary viscosity change in the charge separated polymers.
|
2022-12-17T22:10:13.799Z
|
204,814,230 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acssensors.9b01963",
"MAG": "2982251423",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc6957227?pdf=render"
}
|
Determination of the amino acid phenylalanine is important for lifelong disease management in patients with phenylketonuria, a genetic disorder in which phenylalanine accumulates and persists at levels that alter brain development and cause permanent neurological damage and cognitive dysfunction. Recent approaches for treating phenylketonuria focus on injectable medications that efficiently break down phenylalanine but sometimes result in detrimentally low phenylalanine levels. We have identified new DNA aptamers for phenylalanine in two formats, initially as fluorescent sensors and then, incorporated with field-effect transistors (FETs). Aptamer-FET sensors detected phenylalanine over a wide range of concentrations (fM-mM). para-Chlorophenylalanine, which inhibits the enzyme that converts phenylalanine to tyrosine, was used to induce hyperphenylalaninemia during brain development in mice. Aptamer-FET sensors were specific for phenylalanine vs para-chlorophenylalanine and differentiated changes in mouse serum phenylalanine at levels expected in patients. Aptamer-FETs can be used to investigate models of hyperphenylalanemia in the presence of structurally related enzyme inhibitors, as well as naturally occurring amino acids. Nucleic acid-based receptors that discriminate phenylalanine analogs, some that differ by a single substituent, indicate a refined ability to identify aptamers with binding pockets tailored for high affinity and specificity. Aptamers of this type integrated into field-effect transistors enable rapid, electronic, label-free phenylalanine sensing.
|
2022-12-24T18:23:43.646Z
|
222,589,277 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.1001-9030.2014.09.020",
"MAG": "3032319315",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective To investigate the expression of Toll-like receptor 4 (TLR4) and inflammatory cytokines such as interleukin (IL)-1β,IL-6 and tumor necrosis factor (TNF)-α,and explore the modulatory effect of TLR4 on inflammatory cytokines following fluid percussion brain injury in rats.Methods The experimental models were established in 48 adult rats.The water content of edematous brain and the expression of TLR4,IL-1β,IL-6 and TNF-α were measured with dry-wet measure,and immunohistochemistry at 6,12,24 h,3 day,and 7 day after operation respectively.Results As compared with shamoperated group,the water content of edematous brain was increased in traumatic brain injury (TBI) group from 6 h [(78.86 ± 0.54) ％] to the maximum at 24 h [(83.07 ± 0.27) ％],and gradually decreased at 3 day [(81.85 ± 1.26)％].TLR4,IL-6,IL-1β and TNF-α immunoreactive expression was increased from 6 h (1.50 ± 0.58,3.75 ± 0.48,3.50 ± 0.58,and 5.75 ± 2.36 respectively) to the maximum at 12 h or 24 h (5.50 ± 1.00,7.80 ± 1.64,7.75 ± 1.05,and 7.50 ± 1.73 respectively),lasted to the 3rd day,and began to drop at 7th day.The linear regression analysis indicated that TLR4 expression had positive correlations with expression of IL-1 β,IL-6 and TNF-α (r =0.941,r =0.907,r =0.836 respectively,P ＜ 0.05).Conclusion TLR4,IL-6,IL-1β and TNF-α expression is upregulated following fluid percussion injury in rats,and TLR4 is involved in secondary brain injury by mediating inflammatory cytokines.
Key words:
Toll-like receptor 4; Inflammatory cytokine; Brain injury; Fluid percussion
|
2022-01-27T20:10:54.197Z
|
1,366,357 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0090591",
"MAG": "2042501618",
"PubMedCentral": "3940925"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090591&type=printable"
}
|
Background MicroRNAs (miRNAs) are a class of small non-coding RNAs generated from endogenous transcripts that form hairpin structures. The hairpin precursor is processed into two mature miRNAs that form major/minor duplexes. Mature miRNAs regulate gene expression by cleaving mRNA or repressing protein translation. Numerous miRNAs have been discovered via deep sequencing. Many miRNAs are produced from multiple genome sites. These miRNAs are grouped into paralogous families of miRNAs that generate the same major mature form within organisms. Currently, no method of distinguishing the expression of these miRNAs is available. Results In the present study, strategies were developed to discriminate and quantify the expression of paralogous miRNA precursors. First, paralogous miRNA precursors that were differentially expressed in tissues were identified through analysis of the coexpression scores of their major and minor forms based on deep sequencing data. Then the precursors were identified by monitoring the expression of their host gene or minor form using real-time PCR. Finally, precursors were identified by assessing the expression of clusters of miRNA members. These approaches were used to distinguish miR-128-1 and miR-128-2 as well as miR-194-1 and miR-194-2. The mechanism of transcription related to the differential expression of miR-194-1 and miR-194-2 was also investigated. Conclusion This is the first report to distinguish paralogous miRNA copies by analyzing the expression of major-minor pairs, the host gene, and miRNA clusters. Discriminating paralogous precursors can provide useful information for investigating the mechanisms that regulate miRNA gene expression under different physiological and pathological conditions.
|
2022-07-06T07:01:31.570Z
|
170,131,509 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5840/MONIST197458220",
"MAG": "2334657167",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
At the conclusion of Languages of Art Nelson Goodman suggests that his theory of symbols has implications which extend beyond the philosopher's chambers.2 He indicates that an exploration of the distinctions and frame work introduced in the book might lead to revisions in educational psychol ogy. Work undertaken in recent years by Goodman and his associates at Harvard Project Zero has been directly concerned with the psychological and educational implications of the theory of symbols. I would like to describe some early results of this research, particularly as it concerns two of the concepts discussed in Languages of Art: notationality and similarity. A major portion of Goodman's work is a detailed exposition of the characteristics of a notational system.3 According to his analysis, a symbol system which satisfies the syntactic criteria of disjointness and finite dif ferentiation has a notational scheme; conformity to three additional semantic characteristics of unambiguity, disjointness, and finite differentiation qualifies a set of symbols as a notational system. Goodman concedes that notationality is an ideal and that nearly all our common symbol systems violate at least one criterion of notationality. Nonetheless it is possible to classify symbol systems according to their relation to notationality; such an ordering reveals, for example, that Western music notation fulfills in large measure the semantic and syntactic requirements of a notational system, that ordinary language fulfills the syntactic requirements, and that art forms like painting or sculpture violate all criteria of notationality. The question which interested me initially was this: Is there evidence that psychological mechanisms in volved in working with relatively notational or linguistic schemes differ from
|
2022-09-06T20:28:39.148Z
|
86,939,790 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1096/fasebj.24.1_supplement.633.13",
"MAG": "2292783714",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Students participated in inquiry‐based physiology labs to better understand the structure‐function relationship of major body systems. Students measured their respiration, blood pressure and heart rate while at rest (sitting), standing, lying down, and after 5 and 20 minutes of cardiovascular exercise. Students performed t‐tests on their data, which showed significant correlation during exercise. In a separate experiment, students tested their patellar, plantar, ankle‐jerk and pupillary reflexes under similar conditions, and used inquiry to decide which impulses originated from the central or peripheral nervous system, and to understand and correlate the relationship of these results with the previous experiment. Such modified experiments followed by inquiry based discussions gave students a better insight into understanding the relationship between anatomy and physiology of the organ systems of the body, and their significance to real‐world applications than traditional lab exercises alone.
|
2022-09-30T01:03:54.689Z
|
208,128,284 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3233/icg-190114",
"MAG": "2977282094",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://centaur.reading.ac.uk/83157/1/TCEC%20Cup%203.pdf"
}
|
This is a report of the 'TCEC Cup 3' computational experiment, the 3rd TCEC knockout event and the second major part of TCEC’s 15th season. It featured the best 32 engines of the ‘TCEC 15’ league event and the games were held at Blitz tempo. The different format called for different optimal settings in the engines, thereby enabling a comparison with performance at slower tempi. LEELA CHESS ZERO retained the TCEC Cup, defeating STOCKFISH this time. All decisive games in the supplementary data have been played out by FRITZ17 at search depth 24 to enable and benchmark endgame practice.
|
2022-01-27T01:58:01.475Z
|
23,148,715 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1046/j.1365-2559.2001.01103.x",
"MAG": "2149220935",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis
|
2022-12-15T05:22:56.253Z
|
24,370,501 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/NSSMIC.2004.1466734",
"MAG": "1549106716",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Radiolabeled agents that bind to specific receptors have shown great promise in diagnosing and characterizing tumor cell biology. In vivo imaging of gene transcription and protein expression represents an other area of interest. The radioisotope I is commercially available as a label for molecular probes and utilized by researchers in small animal studies. We propose an advanced imaging detector based on planar NaI(T1) integral assembly with a Hamamatsu Flat Panel Photomultiplier (MA-PMT) representing one of the best trade-offs between spatial resolution and detection efficiency. We characterized the imaging performances of this planar detector, in comparison with a gamma camera based on a pixellated scintillator. We also tested the in-vivo image capability by acquiring images of mice as a part of a study of inflammatory bowel disease (IBD). In this study, four 25g mice with an IBD-like phenotype (SAMP1/YitFc) were injected with 375, 125, 60 and 30 muCi of I-labelled antibody against mucosal vascular addressin cell adhesion molecule (MAdCAM-1), which is up-regulated in the presence of inflammation. Two mice without bowel inflammation were injected with 150 and 60 muCi of the labeled anti-MAdCAM-1 antibody as controls. To better evaluate the performances of the integral assembly detector, we also acquired mice images with a dual modality (X and Gamma Ray) camera dedicated for small animal imaging. The results coming from this new detector are considerable: images of SAMP1/YitFc injected with 30 muCi activity show inflammation throughout the intestinal tract, with the disease very well defined at two hours post-injection.
|
2022-12-21T04:23:39.742Z
|
84,336,065 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/S0006-87051967000100020",
"MAG": "2009634150",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
For the ecological conditions of the state of Sao Paulo, the most important group of grapevines qualified for wine is represented by hybrids Seibel. In Sao Roque, 79 cultivars were studied, of which 7 were separated, considered superior. Although none of them might produce by itself, isolatedly, harmonic and well balanced wines, except in years of special vintage conditions, their association allows to correct characteristics of acidity, sugar percentage and dyeing substances in-order to obtain good wines.
|
2022-12-23T02:13:22.737Z
|
24,818,903 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/MCB.19.10.7168",
"MAG": "2100856409",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT The calcium ionophore ionomycin cooperates with the S100B protein to rescue a p53-dependent G1 checkpoint control in S100B-expressing mouse embryo fibroblasts and rat embryo fibroblasts (REF cells) which express the temperature-sensitive p53Val135 mutant (C. Scotto, J. C. Deloulme, D. Rousseau, E. Chambaz, and J. Baudier, Mol. Cell. Biol. 18:4272–4281, 1998). We investigated in this study the contributions of S100B and calcium-dependent PKC (cPKC) signalling pathways to the activation of wild-type p53. We first confirmed that S100B expression in mouse embryo fibroblasts enhanced specific nuclear accumulation of wild-type p53. We next demonstrated that wild-type p53 nuclear translocation and accumulation is dependent on cPKC activity. Mutation of the five putative cPKC phosphorylation sites on murine p53 into alanine or aspartic residues had no significant effect on p53 nuclear localization, suggesting that the cPKC effect on p53 nuclear translocation is indirect. A concerted regulation by S100B and cPKC of wild-type p53 nuclear translocation and activation was confirmed with REF cells expressing S100B (S100B-REF cells) overexpressing the temperature-sensitive p53Val135 mutant. Stimulation of S100B-REF cells with the PKC activator phorbol ester phorbol myristate acetate (PMA) promoted specific nuclear translocation of the wild-type p53Val135 species in cells positioned in early G1 phase of the cell cycle. PMA also substituted for ionomycin in the mediating of p53-dependent G1 arrest at the nonpermissive temperature (37.5°C). PMA-dependent growth arrest was linked to the cell apoptosis response to UV irradiation. In contrast, growth arrest mediated by a temperature shift to 32°C protected S100B-REF cells from apoptosis. Our results suggest a model in which calcium signalling, linked with cPKC activation, cooperates with S100B to promote wild-type p53 nuclear translocation in early G1 phase and activation of a p53-dependent G1checkpoint control.
|
2022-12-30T00:22:19.221Z
|
100,755,275 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.30906/0869-2092-2016-79-1-12-14",
"MAG": "2257745937",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://ekf.folium.ru/index.php/ekf/article/download/1596/1684"
}
|
Potential neuroprotective activity of the novel antiparkinsonian drug hemantane (hydrochloride N-2-(adamantyl)-hexamethylenimine) in comparison to amantadine has been studied in various regimes of administration on human neuroblastoma SH-SY5Y cell line injury induced by 6-hydroxydopamine (6-OHDA), which is used as in vitro model of dopaminergic neurons for Parkinson’s disease. Two regimes of hemantane and amantadine administration in a range of final concentrations 10 –6 – 10 –8 M were used either prior to or immediately after 6-OHDA introduction. MTT colorimetric assay was used to assess the viability of test cells. Significant decrease in viability of SH-SY5Y cells treated with 6-OHDA was observed. The addition of hemantane to cell medium produced cytoprotective effects in both regimes of administration — before and after 6-OHDA—at concentrations 10 –7 M and 10 –6 – 10 –8 M, respectively. Amantadine in concentrations 10 –7 – 10 –8 M was effective to increase cell survival only when administered after 6-OHDA. These results show that hemantane has a greater neuroprotective potential in comparison to amantadine.
|
2022-01-27T09:04:53.528Z
|
65,409,475 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17851/1982-3053.12.22.280-283",
"MAG": "2806223984",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://periodicos.ufmg.br/index.php/maaravi/article/download/14445/pdf"
}
|
Resenha a: VALENTE, Luize. Sonata em Auschwitz. Rio de Janeiro: Record, 2017. 376 p.
|
2022-01-24T20:50:18.651Z
|
76,138,395 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1177/0972063412468982",
"MAG": "2323011602",
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},
"license": null,
"status": null,
"url": null
}
|
Right to health ensures health care to all irrespective of any socio-economic and cultural differences. Since the late 1980s, HIV/AIDS has emerged as an epidemic in India and it has put forth several challenges like medical, socio-economic isssues. The health problem has more adverse effects on vulnerable sections of the society like the poor and women. In such a context, there is a need for the state to address the issue in a way that the health rights of women could be ensured effectively. In this article, we explore the role of the state in ensuring health rights of HIV positive women. Two states are selected, i.e., Karnataka (one of the high prevalence states) and West Bengal (one of the low prevalence states) to examine the difference of performance of state towards assurance of health rights of women. One of the vital parameters of health rights, i.e., accessibility of health care and treatment is considered. We found that despite initiatives taken by the states, accessibility of health care has remained an oasis for many HIV positive people. More importantly, state governments fail in ensuring accessibility of health care facilities due to widespread instances of treatment denial, discrimination and absence of counselling.
|
2022-02-11T06:41:24.446Z
|
136,478,363 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.4980810",
"MAG": "2619124849",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Bioactive sample of the composition 41CaO-8P2O5-17MgO-34SiO2 has been prepared in the laboratory by quick alkali mediated sol-gel method. 1M ammonia solution has been used to form the gel. Bioactivity of the sample has been analyzed by soaking the samples in simulated body fluid. Degradation study has also undertaken to check the degradation behavior of the sample. MTT cytotoxic test has also been done to know the toxicity of the sample and results show that samples has good percentage of cell viability in the cell culture media. Formation of the hydroxyapatite has been confirmed by the XRD, Raman spectroscopy and FESEM-EDX study.
|
2022-08-03T22:17:33.711Z
|
211,347,321 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4324/9780203771457-8",
"MAG": "2982015883",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Legal change is often thought of as change from the top down – change brought about by new legislation, regulations, precedent administrative, and federal court decisions, or changes resulting from major impact litigation. Gender asylum in the United States, however, tells an unusual story of legal change from the bottom up, grounded, at least in significant part, in direct representation of women refugees. There is a long theoretical debate about progressive lawyering for social justice and legal change. Many critical theorists doubt the role of direct services and individual representation, while some argue more generally that instrumental uses of the law justify the status quo and are ineffective and even counter-productive, legitimizing the law in ways that in fact impede legal and social change (Alfieri 2008–09; Wexler 1970). This chapter, in telling at least part of the story of gender asylum in the United States, provides a counter-example of how direct representation can actually change the culture of decision-making and be an effective vehicle for meaningful legal change. At the same time, such representation, rather than disempowering clients (Quigley 1994), can create authentic and non-hierarchical relationships between lawyer and client as I hope the case examples provided in this chapter illustrate. In the narratives that accompany these asylum claims, lawyers, in partnership or ‘alliance’ with their clients (Bellow 1996), develop narratives that portray women refugees not as simple victims, or fitting only within the Refugee Convention’s particular social group ground, but rather, for example, as in cases involving domestic violence, as having feminist political opinions that led to them standing up to their abusers. This chapter, as well as other works, also describes the relationship between direct representation and coalition building for social change with lawyers engaged in such direct representation allying with client-based and other community organizations (Anker 2002; Sharpless 2012). From the enactment of the
|
2022-09-08T23:57:12.024Z
|
153,856,345 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S1053837210000337",
"MAG": "2024129366",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper we address the subject of Keynes as a speculator. We look first at the primary sources of information, which are in the form of unpublished letters and broker’s statements. Secondly, we look at the theory Keynes sparingly presented in his writings, but which nevertheless is grounded on his first-hand knowledge of speculative behavior. Thirdly, we examine the focus on speculation in commodities, which had great weight in his portfolio, and have chosen a particular commodity -wheat- for our investigation. In particular, we examine some of Keynes’s dealings in wheat futures with the aim of shedding light on the underlying investment strategy.
|
2022-09-10T20:03:32.007Z
|
225,685,549 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3341/jkos.2020.61.6.630",
"MAG": "3034925368",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://www.jkos.org/upload/pdf/jkos-2020-61-6-630.pdf"
}
|
Purpose: To evaluate long-term clinical outcomes in patients with neovascular age-related macular degeneration (AMD) who were treated with an as-needed regimen but were switched to a proactive regimen during the course of treatment. Methods: This retrospective study included 23 eyes with neovascular AMD which were initially treated with an as-needed regimen, but switched to a proactive regimen during the course of treatment. The duration of the as-needed phase was compared to that of the proactive phase. In addition, the number of injections per year and the degree of visual deterioration per year were compared between the two phases. Results: The duration of the as-needed and proactive phases were 17.9 ± 8.3 months and 31.3 ± 13.2 months, respectively. The duration of the proactive phase was significantly longer (p < 0.001). The number of injections per year during the proactive phase (4.4 ± 1.0) was significantly more than that during the as-needed phase (2.8 ± 1.0) (p < 0.001). The degree of visual deterioration per year during the as-needed phase (0.08 ± 0.14) was slightly greater than that during the proactive phase (0.04 ± 0.08). However, the difference was not statistically significant (p = 0.229). Conclusions: The number of injections was higher after switching to the proactive regimen. However, the degree of visual deterioration was slightly lower than that noted during the as-needed phase. Further studies with a more controlled design are needed to determine more clearly the impact of switching treatment regimens on long-term clinical outcomes. J Korean Ophthalmol Soc 2020;61(6):630-638
|
2022-09-11T02:27:09.035Z
|
151,499,574 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/ASR.2015.75",
"MAG": "2588935392",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract: Recent experimentation by Nollywood producers has encouraged increasing differentiation of film practices as a strategy for contending with a demanding video market. “New Nollywood” refers to a select group of aesthetically sophisticated films intended for a new tiered distribution method, beginning with theatrical release and ending with DVD release. Nigeria’s upscale multiplex cinemas are therefore a starting point for examining what is new—and not so new—in Nollywood. This article argues that New Nollywood films and the cinemas in which they appear appeal directly to spectators’ senses by promising not only a movie and shopping, but also an affective experience closely bound up with global consumerism. The films exhibit a metropolitan vantage point that emphasizes subjects such as airline travel, trendy technology, consumer culture, global pop culture, lifestyle brands, high fashion, and luxury goods. These films advertise their “modernity,” which is not presented as a consolidated order of knowledge and values, but rather as an assemblage of signifiers of city life. Whereas mainstream Nollywood continues to produce strong narratives that resonate with its intended audience, New Nollywood—with its emphasis on images and style—is a direct expression of the cultural and economic forces shaping life in Lagos today. Résumé: L’expérimentation récente par les producteurs de Nollywood a encouragé la différenciation croissante de pratiques de cinéma en tant que stratégie permettant de soutenir un marché de la vidéo en constante évolution. “Nouveau Nollywood” fait référence à un groupe restreint de films esthétiquement sophistiqués destinés à une nouvelle méthode de distribution à plusieurs étapes, en commençant par la sortie en salles et en se terminant avec la sortie en DVD. Les cinémas multiplexes haut de gamme du Nigeria sont donc un point de départ pour examiner ce qui est nouveau—et pas si nouveau—dans Nollywood. Cet article affirme que les films de Nouveau Nollywood et les cinémas dans lesquels ils sortent font appel à la sensibilité des spectateurs en mettant l’accent sur les thèmes de connectivité, mobilité et contemporanéité et en reliant ces thèmes avec le consumérisme mondial. Les films présentent un point de vue métropolitain qui met l’accent sur des sujets tels que les voyages en avion, la technologie à la mode, la culture de consommation, la culture pop mondiale, les marques vestimentaires, la haute couture et les produits de luxe. Ces films annoncent leur “modernité,” qui n’est pas présentée comme un ordre consolidé des connaissances et des valeurs, mais plutôt comme un ensemble de signifiants de la vie en ville. Alors que le Nollywood traditionnel a maintenu une connexion avec l’imaginaire populaire de son public cible, le Nouveau-Nollywood avec son accent sur les images et le style est une expression directe des aspirations culturelles et économiques qui façonnent la vie à Lagos aujourd’hui.
|
2022-09-13T21:26:44.193Z
|
6,291,544 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.2042-7158.1978.tb13394.x",
"MAG": "2006333985",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
High concentrations of acetylcholine, choline acetyltransferase and cholinesterase are found in the striatum, probably within a system of cholinergic interneurons (McGeer & others, 1975; Butcher, 1977). These cholinergic interneurons appear to be inhibited, functionally, by the dopaminergic nigrostriatal pathway. Thus, neuroleptic drugs, which are dopamine antagonists, have been shown to decrease striatal acetylcholine concentrations and increase acetylcholine release (Stadler, Lloyd & others, 1973; Consolo, Ladinsky & Garattini, 1974; Consolo, Ladinsky & Bianchi, 1975; Consolo, Ladinsky & others, 1977). The reverse is also true in that the dopamine nigrostriatal pathway appears t o be inhibited functionally by a cholinergic input. Thus, neuroleptic-induced increases in striatal dopamine turnover can be reversed, a t least partially, by the administration of antiacetylcholine drugs (O’Keefe, Sharman & Vogt, 1970; AndCn, 1972; Corrodi, Fuxe & Lidbrink, 1972; Bartholini, Keller & Pletscher, 1975). In another dopamine containing area, the mesolimbic system, high concentrations of acetylcholine also are present. However, in contrast to the striatum, the relation between dopaminergic and cholinergic pathways within the mesolimbic area is unclear. Thus, while administration of oxotremorine or physostigmine results in an increase in limbic (and striatal) homovanillic acid (HVA) concentrations, effects reversible by trihexiphenidyl (AndCn, 1974), dopamine agonists and antagonists failed to alter acetylcholine concentrations or release in the tuberculum olfactorium and nucleus accumbens in doses effective in the striatum (Stadler, Gadea-Ciria & Bartholini, 1975; Consolo & others, 1977). Further, neuroleptic-induced increases in mesolimbic HVA concentrations have been reported not to be reversed by antiacetylcholine drugs (Anden, 1972). Substituted benzamide drugs such as sulpiride and metoclopramide represent an unusual group of dopamine receptor antagonists. Thus, while blocking locomotor activity induced by apomorphine, inhibiting apomorphineand amphetamine-induced circling behaviour and increasing both striatal and mesolimbic dopamine turnover, these compounds have little cataleptic activity, do not inhibit dopamine stimulated adenylate cyclase in rat striatal preparations, and only
|
2022-12-12T12:54:14.454Z
|
5,408,210 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4103/0976-237X.152961",
"MAG": "2089677577",
"PubMedCentral": "4374305"
},
"license": null,
"status": null,
"url": null
}
|
Mandibular resection following surgical treatment for neoplastic lesions of the oral cavity leads to numerous complications including altered mandibular movements, disfigurement, difficult in swallowing, impaired speech and articulation, and deviation of the mandible towards the resected site. Various prosthetic methods are employed to reduce or minimize mandibular deviation and improve and restore the lost functions and esthetic, like maxillomandibular fixation, implant supported prosthesis, removable mandibular guide flange prosthesis, and palatal based guidance restoration. This clinical report describes the rehabilitation of a patient following segmental mandibulectomy using palatal ramp prosthesis.
|
2022-12-14T22:14:40.320Z
|
128,453,016 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1029/LN022P0209",
"MAG": "1871486554",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Coral reef community metabolic rates can be high. Autotrophic and heterotrophic communities apparently maintain high rates by juxtaposition of “patches” or zones which intercept and process metabolic products swept from upstream within the system. The net result is that the new carbon production of entire coral reef systems appears no more than slightly elevated above the new production of plankton communities in the surrounding surface ocean.
|
2022-12-16T21:17:56.833Z
|
44,325,561 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/BOT.0000000000000274",
"MAG": "2276333285",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The contour of the ilium is curved and the iliac fossa is thin, making adequate fixation for fractures involving the iliac wing challenging to achieve at times. The purpose of this article is to describe a previously unreported technique for enhancing fixation in iliac fractures using simple cortical screws.
|
2022-12-21T01:36:22.578Z
|
85,849,636 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3176/PROC.2013.3.03",
"MAG": "2147160688",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The content and composition of essential oils in leaves of Mentha × piperita L., M. spicata L., M. arvensis L., and M. longifolia (L.) Huds. from Estonia were investigated using hydrodistillation and GC-MS analyses. Some chemosystematic markers for the identification of Mentha species are presented. The essential oil yield of the studied species was 2.4-3.0%, 0.9- 2.3%, 0.9-1.4%, and 0.7-2.5%, respectively. From the isolated essential oils, 75, 89, 67, and 69 compounds were identified and quantitatively evaluated, representing 92.2-99.5% of the total oil. The main constituents of M. × piperita oils were menthol (26.4- 47.7%) and menthone (13.6-31.9%); the ratio of their content was usually between 1 and 3. Four chemotypes of M. spicata were determined: rich in carvone (62.1-67.4%), rich in piperitenone oxide (61.9%), rich in α-terpinyl acetate + trans-β-caryophyllene (61.9% and 11.4%, respectively), and rich in acetic acid,1-methyl-1-(4-methyl-5-oxo-cyclohex-3-enyl) ethyl ether (6.5%). The last two chemotypes were determined for the first time. Only the essential oils of M. arvensis were found to contain trans-1-octen- 3-ol (3.8-7.7%) and neryl propionate (2.4% in both samples). Good chemosystematic markers for M. arvensis were also trans- (16.0-19.1%) and cis-β-ocimene (16.0-20.5%). The ocimene-rich chemotype was found by us for the first time. The chemosystematics of M. longifolia was found to be the most complicated, as many chemotypes have been determined by us and several other authors. In this study, a high concentration of carvone (51.4-57.6%) was characteristic of all analysed M. longifolia samples.
|
2022-12-23T15:54:49.973Z
|
128,756,873 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15517/REVEDU.V25I1.2932",
"MAG": "2003684811",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
La tematica acerca de la adecuacion curricular es de gran interes para los profesionales de la Educacion. El reto de lograr aprendizajes que atiendan la individualidad en los estudiantes, pone de manifiesto la necesidad de que dichos aprendizajes sean significativos, lo cual implica necesariamente procesos de contextualizacion y docentes capaces de desarrollar un curriculo demanera creativa y asumiendo el rol de investigadores ensu accionar cotidiano.El presente articulo trata de dar a conocer la forma enque la adecuacion curricular puede verse desde una optica institucional e individual
|
2022-02-09T15:25:02.337Z
|
125,053,617 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3788/AOS201434.0822001",
"MAG": "2328574568",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Because of the large number of the lenses in a small scale projected objective, it is unsuitable to use a traditional method that each compensator only compensates the corresponding misalignment. A sensitivity matrix is utilized to solve this problem. The sensitivity matrix is decomposed using singularly valuable decomposition method. The values and signs of displaced parameters vector are analyzed, and the correlations among each displaced parameter are obtained. A method of selecting a set of optimum combination of system compensators which only need to analyze a few displaced parameters vectors is proposed. The selected compensators are proved as correct by massive simulation calculations with the aiding of macro commands modes. After the original assembling, a pre-aligning procedure of optical system is carried out to ensure the feasibility of the aligning scheme. Test results show that the wave front errors root mean square (RMS) reduced to 29.6 nm from 70 nm after compensating, which is better than the requirements of the qualifications. The results prove the methods of selecting compensators are right and effective.
|
2022-02-09T18:22:14.505Z
|
75,527,807 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5794/JJOMS.31.372",
"MAG": "2330692353",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Two cases with the mandibular defect were reconstructed with free vascularized osteocutaneous iliac grafts using deep circumflex iliac vessels as the stem. The immediate and late postoperative results after about 3 years follow-up were very satisfactory from the functional as well as the aesthetic aspect.
|
2022-02-11T07:14:19.025Z
|
35,510,033 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2307/1409968",
"MAG": "1987650174",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In a celebrated paper published in 1978, Elizabeth Landes and Richard Posner articulated perceived defects in the regulatory control of adoptions in the United States. They argued that the prevalent shortage of babies for adoption and the resultant illicit trade might be promoted by legal restrictions which prevented the market from operating as freely in the exchange of babies as of other goods.1 They highlighted the absence of evidence suggesting that willingness to pay would adversely affect the welfare of the child and noted comparable market considerations accompanying procreative decisions.2 Concluding with a "highly tentative" proposal, they suggested an interim move toward a fully-fledged baby market; the simulation by some adoption agencies of market characteristics in paying pregnant women contemplating abortion a fee to carry the foetus to term and to place the baby for adoption.3 A subsequent response by Robert Pritchard underlined some of the benefits which a market for babies could afford.4 But he identified three types of objection to the argument; these he characterised as market failure problems, objections in principle and finally a statement of the misconceptions which he thought underscored Landes and Posner's work. Identifying the outer limits of market analysis, he complained that:
|
2022-09-06T03:01:28.719Z
|
122,325,633 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.1144069",
"MAG": "2052671879",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Electrochemically etched tungsten scanning tunneling microscope (STM) tips are dc sputter coated with 20 nm of gold (0.04 nm/s and 10 mTorr of argon). Transmission electron microscope (TEM) images of typical etched tips and gold‐coated etched tips are presented. The gold layer forms as a series of spherical sections having a mean height of 6.7 nm and mean width of 19.6 nm. STM images are reported for the uncoated W tips, and for gold‐coated graphite after coating the tip with gold. We also provide scanning electron microscopy (SEM) and STM images of the surface of a thin CuTCNQ film. The STM image taken with a gold‐coated W tip compares very well to the SEM image of the same sample. Gold coating provides a relatively inexpensive and easy way to produce chemically stable tips of well known electronic structure for use in ambient atmosphere STM studies of morphology (structures ≥10 nm) where atomic resolution is not required.
|
2022-09-10T20:47:05.990Z
|
26,130,834 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/lpt.2002.807929",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A novel numerical method for the standard propagation equations of Raman amplifiers with multiple pumps is presented and derived based on the four-step Adams-Bashforth method. Our proposed multistep method can increase the accuracy and stability in designing Raman amplifiers compared with the one-step method. Output signal, pump, and backscattering pump powers have been numerically simulated and compared by utilizing our multistep method and one-step method. The results show that our method can reduce the computing time over three orders of magnitude with excellent accuracy by comparison with the direct integration method for the Raman amplifier propagation equations.
|
2022-09-15T08:53:19.113Z
|
224,990,264 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18682/CDC.VI119.4303",
"MAG": "3090046749",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
En los últimos años las revueltas sociales en Latinoamerica han estado acompañadas por una nueva forma de interveción estético-política. Lo que podríamos denominar intervenciones audiovisuales en espacio público. Con la intención de empezar a trazar un recorrido histórico por diversas experiencias que han utilizado la intervención audiovisual como herramienta de ataque simbólico en diversa arquitectura hegemónica. En este texto analizaremos la experiencia del artista polaco Krzysztof Wodiczko, quien con sus proyecciones públicas constituye uno de los referentes principales de este nuevo lenguaje lúminico-proyectivo. Este trabajo indaga de manera somera en sus postulados estéticos al momento de realizar sus proyecciones públicas sobre diversa arquitectura y monumentos públicos y corporativos, así como su interés primario de desmarcarse de la noción de arte público y el intento de cuestionar en cada una de sus acciones la noción de público y privado. Igualmente profundizamos en el paso que el artista polaco ha tenido por Latinoamerica en los ultimos años y como podríamos pensar esto como un germen de las acciones proyectivas desobedientes que ahora iluminan nuestros territorios.
|
2022-10-21T00:54:13.160Z
|
39,927,882 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15415/JNP.2013.11009",
"MAG": "1964199126",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Photon interaction effective atomic number (Zeff) for partial as well as total photon interaction processes has been computed using logarithmic interpolation method for seven different concretes viz. (i) Ordinary, (ii) Hematite - Serpentine, (iii) Ilmenite - Limonite, (iv) Basalt - magnetite, (v) Ilmenite, (vi) Steel - scrap and (vii) Steel - magnetite concrete in the wide energy range from 10.0 keV to 100 GeV. It has been concluded that this method has an advantage over the atomic to electronic cross-section ratio method especially for mixtures in the intermediate energy level. However, due to lack of experimental data in the higher energy region, it is difficult to discuss, its validity in these energy regions.
|
2022-11-25T19:29:33.089Z
|
221,886,003 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S1049023X20001132",
"MAG": "3088849617",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Background: To investigate if toll-like receptor (TLR) 4/nuclear factor-kappa B (NF-κB) signaling pathways mediated crush injury induced acute kidney injury (AKI) in rats, and if TAK-242 (a specific inhibitor of TLR4) attenuates the injury through inhibiting the signaling pathways. Methods: This study was divided into two parts: (1) Establish the crush injury model: 50 rats were randomly divided into control group and four crush injury groups (n = 10/group). Crush injury groups were given 3kg pressure for eight hours and were sacrificed at the time points of 0h, 6h, 12h, and 24h after relieving pressure. And (2) Select the most obvious injury group (12h group) for drug intervention group. Thirty rats were randomly divided into control group, 12h group, and 12h+TAK-242 group (n = 10/group). Two parts detection were as follows: pathological changes of kidney tissues were observed in Haematoxylin and Eosin (HE) staining. Serum creatinine, blood urea nitrogen (BUN), myoglobin (Mb), and blood potassium were examined by automatic biochemical analysis instrument. Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured by enzyme-linked immunosorbent assay (ELISA). The TLR4 messenger ribonucleic acid (mRNA), TLR4, and P65 were detected by real-time polymerase chain reaction (PCR), western blot, immunohistochemistry staining. Results: Compared with the control group, kidney tissues were damaged in crush injury groups, and most obvious in the 12h group. The level of serum creatinine, BUN, Mb, blood potassium, IL-6, TNF-α, and TLR4mRNA were increased in the crush injury groups and significantly increased in the 12h group (P <.05). The TLR4 and P65 were significantly increased in the 12h group (P <.05). Compared with the 12h group, kidney tissue damage was significantly reduced in the TAK-242 group (P <.05). The level of serum creatinine, BUN, Mb, blood potassium, IL-6, TNF-α, TLR4mRNA, TLR4, and P65 in the TAK-242 group were significantly reduced (P <.05). Conclusion: The present findings conclude that TLR4/NF-κB signaling pathways mediated crush injury induced AKI in rats, and TAK-242 attenuates the injury through inhibiting the signaling pathways.
|
2022-12-12T11:04:08.661Z
|
9,691,241 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4158/EP.13.5.458",
"MAG": "1995329811",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
OBJECTIVE
To report the outcomes of tumor-induced osteomalacia after treatment, particularly related to recovery of bone mass.
METHODS
We review the clinical course of a 61-year-old man extremely debilitated from multiple fractures and neuromuscular weakness due to tumor-induced osteomalacia and report the changes in biochemical markers and bone density after removal of the causative neoplasm.
RESULTS
At the time of diagnosis, the patient's serum phosphorus and 1,25 dihydroxyvitamin D levels were depressed, and his fibroblast growth factor-23 level was markedly elevated. These values normalized 2 days after surgery and remained within their respective reference ranges 4 and 12 months after resection of a mesenchymal tumor. Lumbar bone density values (T-scores) were 0.445 g/cm2 (-5.9) preoperatively, 0.939 g/cm2 (-1.4) 4 months after surgery, and 1.152 g/cm2 (0.7) 12 months after surgery. Left femoral neck values at the same time points were 0.525 g/cm2 (-3.0), 1.035 g/cm2 (-0.8), and 1.184 g/cm2 (1.9). Ultra-distal radius values at the same time points were 0.128 g/cm2 (-7.0), 0.191 g/cm2 (-5.9), and 0.259 g/cm2 (-4.8). In addition, he recovered neuromuscular function and was able to leave his wheelchair.
CONCLUSION
Tumor-induced osteomalacia can be an extremely debilitating disease. With successful localization, identification, and resection of the neoplasm, bone mass and physical function can recover.
|
2022-12-14T12:46:59.258Z
|
20,113,618 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/ced.12556",
"MAG": "2092628535",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Alopecia areata (AA) is an inflammatory autoimmune disease that causes hair loss on the scalp or trunk without scarring. Although the precise aetiopathogenesis of alopecia areata remains unknown, oxidative stress is thought to play a role.
|
2022-12-18T23:25:39.380Z
|
84,841,911 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1152/jn.00779.2018",
"MAG": "2925110932",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://journals.physiology.org/doi/pdf/10.1152/jn.00779.2018"
}
|
Many synapses, including parallel fiber synapses in the cerebellum, express presynaptic GABAA receptors. However, reports of the functional consequences of presynaptic GABAA receptor activation are variable across synapses, from inhibition to enhancement of transmitter release. We find that presynaptic GABAA receptor function is bidirectional at parallel fiber synapses depending on GABA concentration and modulation of GABAA receptors in mice. Activation of GABAA receptors by low GABA concentrations enhances glutamate release, whereas activation of receptors by higher GABA concentrations inhibits release. Furthermore, blocking GABAB receptors reduces GABAA receptor currents and shifts presynaptic responses toward greater enhancement of release across a wide range of GABA concentrations. Conversely, enhancing GABAA receptor currents with ethanol or neurosteroids shifts responses toward greater inhibition of release. The ability of presynaptic GABAA receptors to enhance or inhibit transmitter release at the same synapse depending on activity level provides a new mechanism for fine control of synaptic transmission by GABA and may explain conflicting reports of presynaptic GABAA receptor function across synapses. NEW & NOTEWORTHY GABAA receptors are widely expressed at presynaptic terminals in the central nervous system. However, previous reports have produced conflicting results on the function of these receptors at different synapses. We show that presynaptic GABAA receptor function is strongly dependent on the level of receptor activation. Low levels of receptor activation enhance transmitter release, whereas higher levels of activation inhibit release at the same synapses. This provides a novel mechanism by which presynaptic GABAA receptors fine-tune synaptic transmission.
|
2022-12-23T02:23:59.253Z
|
46,290,557 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/OEM.14.2.92",
"MAG": "2132303561",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The measure of control of respiratory tuberculosis in industry through mass radiography, assuming the service to be accepted and organized at regular intervals, depends mainly on how great a proportion of employees volunteer for radiological examination at any one time. The response varies between different factories and in our experience may be from 5 to 100%. Such a wide range cannot be explained solely by differences in the attitude of individual workers. There are obviously other fac tors to be considered. One of the more tangible factors which may affect participation in a mass radiography survey, and one which could influence both employees and management, is the distance which volunteers have to travel from their place of work to the unit. It is reasonable to assume that the nearer the unit is situated to the employees, the better the response will be. In practice, however, it is not easy to move rapidly the complicated machinery of a radiography unit, and the premises of small factories may be inadequate, with the result that surveys of small groups of employees may prove uneconomical. It is, therefore, a matter of some importance to explore the extent to which atten dance figures depend on the distance separating examinees from the unit in relation to the size of the factory concerned. With this aim in view, a mass radiography survey covering a compact industrial estate was organized in 1955 on the following lines:? (1) At 52 factories the unit operated successively in the centre of a number of areas, the radius of which did not exceed 100 yards. (2) Twenty-four factories were visited individually, with the unit operating in the factory grounds. The attendance figures were then compared with those of the 1953 survey in which the unit worked on a single site and all the factories were situated within approxi mately one mile of it. In both surveys the same 76 factories were involved and the same type of propaganda was used. In only four factories was the number of employees in 1955 much different from that in 1953. The results are shown in Table 1. There was no appreciable difference between the responses in the two surveys. The slightly higher response for smaller factories in 1955 was com pensated by a slightly lower response in the larger establishments. Both surveys covered the same factories, with little change in the age and sex structure of their respective employees. In our experience repeat surveys result, if anything, in a higher response than first surveys. It appears, there fore, that by bringing the unit almost to the doorstep of the factory, no improvement in attendance was
|
2022-04-07T07:07:57.453Z
|
84,314,132 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4267/2042/37755",
"MAG": "2008840996",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Review on MKL1 (megakaryoblastic leukemia (translocation) 1), with data on DNA, on the protein encoded, and where the gene is implicated.
|
2022-05-10T00:19:35.433Z
|
248,997,988 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/cbo9781316151464.152",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
International Organization — Officials of United Nations — Contracts of Employment — Fixed-term Contracts — Termination of — Discretion of Organization in the Matter of Renewal of Contracts
|
2022-05-24T14:55:29.612Z
|
250,678,326 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1742-6596/363/1/011002",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/363/1/011002"
}
|
This is a co-publication with Classical and Quantum Gravity which also features papers from the Edoardo Amaldi Conference on Gravitational Waves (Amaldi 9) and Numerical Relativity and Data Analysis 2011 (NRDA2011).
|
2022-07-21T04:06:43.204Z
|
14,054,758 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2337/DIABETES.53.4.1096",
"MAG": "2136025024",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Diabetes macro- and microvascular disease causes tissue hypoperfusion. This deficit, together with a failure to mount an adequate angiogenic response, might explain why vascular occlusion evolves more severely among diabetic patients. The present study investigated whether prophylactic gene therapy with human tissue kallikrein (hTK) may protect diabetic limbs from the consequences of supervening ischemia. Vehicle (saline) or an adenovirus carrying the gene for either hTK (Ad.hTK) or luciferase (Ad.Luc) was injected into left adductor muscles of streptozotocin-induced type 1 diabetic mice 2 weeks before operative occlusion of the ipsilateral femoral artery. Saline-injected nondiabetic mice served as controls. Hindlimb blood flow recovery was analyzed sequentially over the 2 weeks after ischemia induction. At necroscopy, microvessel density and endothelial cell proliferation and apoptosis were quantified in skeletal muscles. We found that limb perfusion recovery of saline-injected type 1 diabetic mice is delayed because of insufficient reparative neovascularization and excessive activation of endothelial cell apoptosis. By contrast, prophylactic Ad.hTK renewed the ability to mount an appropriate neovascularization response to ischemia, suppressed apoptosis, and upregulated endothelial nitric oxide synthase expression. Ultimately, correction of diabetic endotheliopathy by Ad.hTK allowed proper perfusion recovery as seen in nondiabetic mice. These discoveries disclose new therapeutic options for the treatment of diabetic complications.
|
2022-12-09T09:08:35.104Z
|
28,406,670 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1126/SCIENCE.7352263",
"MAG": "2084374224",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Nerve fibers transmitting information from the thalamus to the cerebral cortex may be classified according to their major cortical layers of termination. (i) One class consists of inputs from thalamic relay nuclei for vision, audition, and somesthesis to layer IV, layer III, or both. In contrast, autoradiographic studies of projections from other thalamic nuclei reveal strikingly different patterns of termination: (ii) layer VI (or layer V, or both) is the target of fibers from the intralaminar nuclei, and (iii) layer I is the target for fibers from the ventromedial and magnocellular medial geniculate nuclei. (iv) The remaining class is typified by termination both in layer I and in additional layers that depend on the cortical area in which the terminations are found. The data demonstrate that convergent thalamic inputs to a given cortical area are usually not confluent within a layer and provide a new frame-work for categorizing thalamic nuclei.
|
2022-12-20T07:40:13.450Z
|
28,408,308 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TWC.2012.092712.100868",
"MAG": "1966896253",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper, we discuss problems in densely deployed wireless networks. Particularly, we focus on wireless local area networks (WLANs) because they have enabled us to provide seamless and high capacity wireless access easily and inexpensively. However, recently, channel interference between different services has become a serious problem because access points (APs) of WLANs are located too densely. In the carrier sense multiple access with collision avoidance used in WLANs, the hidden terminal (HT) and the exposed terminal (ET) problems occur depending on the distance between stations and the carrier sensing range. In the higher dense deployment mentioned above, the HT and ET problems occur complicatedly. Therefore, we propose an AP cooperation system that detects the HT and ET problems between stations (STAs). In our system, APs are operated with time synchronization and obtain the information of connected STAs from received frames. The HT and ET problems are identified from the integration of the information obtained at different APs. The effectiveness is verified by simulations.
|
2022-12-26T18:20:59.516Z
|
233,030,060 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fcell.2021.659783",
"MAG": null,
"PubMedCentral": "8055942"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fcell.2021.659783/pdf"
}
|
Traumatic optic neuropathy (TON) refers to optic nerve damage caused by trauma, leading to partial or complete loss of vision. The primary treatment options, such as hormonal therapy and surgery, have limited efficacy. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38), a functional endogenous neuroprotective peptide, has emerged as a promising therapeutic agent. In this study, we used rat retinal ganglion cell (RGC) exosomes as nanosized vesicles for the delivery of PACAP38 loaded via the exosomal anchor peptide CP05 (EXOPACAP38). EXOPACAP38 showed greater uptake efficiency in vitro and in vivo than PACAP38. The results showed that EXOPACAP38 significantly enhanced the RGC survival rate and retinal nerve fiber layer thickness in a rat TON model. Moreover, EXOPACAP38 significantly promoted axon regeneration and optic nerve function after injury. These findings indicate that EXOPACAP38 can be used as a treatment option and may have therapeutic implications for patients with TON.
|
2022-12-29T16:41:11.883Z
|
245,031,361 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1542/peds.54.3.386a",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Although in accord with Dr. Wineberg's letter (Pediatrics, 52:888, 1973) regarding the interleaving of advertising in Pediatrics, I think the practice of pharmaceutical advertising in a professional journal must be challenged once again. Dr. Frazier's comment in regard to this is weak (Pediatrics, 52:767, 1973).
Physicians should receive information about new and tested treatments or drugs from reputable and unbiased sources. Their use should not be promoted using sophisticated advertising techniques by parties whose primary interest is in selling their particular product.
|
2022-01-27T19:42:20.771Z
|
102,628,486 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.30638/eemj.2004.038",
"MAG": "2801768171",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
In this study, the obtaining of some composite materials using wood chips as filler and a modified polyamidic polymer as thermoplastic matrix is presented. Characterization was carried out on composite samples by analysis of morphology, mechanical properties and thermal behaviour. It was observed that the tensile strength of composites decreased significantly with the increasing wood chips content. Still, even the bending strength is decreasing; it remains 2-8 times higher than that for the composites based on polyolefinic matrices. The thermal stability of the obtained composite materials is higher to that of the initial wood component.
|
2022-02-10T09:40:38.781Z
|
1,465,586 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11575/PRISM/30691",
"MAG": "2184095692",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
plus context displays combine high-resolution detail and lower-resolution overview using displays of different pixel densities. Historically, they employed two fixed-size displays of different resolutions, one embedded within the other. In this paper, we explore focus plus context displays using one or more mobile projectors in combination with a stationary display. The portability of mobile projectors as applied to focus plus context displays contributes in three ways. First, the projector's projection on the stationary display can transition dynamically from being the focus of one's interest (i.e. providing a high resolution view when close to the display) to providing context around it (i.e. providing a low resolution view beyond the display's borders when further away from it). Second, users can dynamically reposition and resize a focal area that matches their interest rather than repositioning all content into a fixed high-resolution area. Third, multiple users can manipulate multiple foci or context areas without interfering with one other. A proof-of-concept implementation illustrates these contributions.
|
2022-09-09T03:28:22.752Z
|
46,095,959 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/1012319.1012322",
"MAG": "2012964417",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://dl.acm.org/doi/pdf/10.1145/1012319.1012322"
}
|
of Comments : Offering a critique on programming language desig n provides one the open opportunity for cheap shots. Th e potential for exciting advances in the field i s overwhelming, yet the actual invention and development o f new ideas is elusive. Over the last ten to fifteen years , the impact of language on real system development has bee n negligible. The singular significant advance in programmin g languages occurred nearly twenty years ago : the movemen t from machine/assembly language programming to algebrai c (FORTRAN,ALGOL60) and data processing (COBOL) languages. O f course, there have been other interesting language s developed (e .g .,APL, LISP, SNOBOL, RPG) with significan t impacts to narrow communities. But, the basic approach o f data processing and system development programmers ha s changed little, overall, and even less because of languag e development. In optimistic moods, I believe we may see anothe r significant advance in language design, soon. "Higher " level languages have, for a long while, held the hope o f salvation. The problem has been to figure out specificall y just what "higher" might mean. It generally has been use d to mean, away from the machine and toward the programmer' s problem domain. Two things make this difficult : 1) Programmers, even in this age of modern high-spee d machines, must maintain a strong concern for efficienc y and good utilization of machines. Our ability t o capture their talents, in mapping a problem into a n efficient program, and to incorporate them into a program building program (compiler) is primitive. 2) Problem domains are quite diverse. Movement toward a problem domain is particular to the domain. Genera l solutions must provide incredible flexibility an d adaptability. .
|
2022-09-10T22:22:09.646Z
|
235,713,868 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/cells10071622",
"MAG": null,
"PubMedCentral": "8305598"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2073-4409/10/7/1622/pdf?version=1624947056"
}
|
Primary sclerosing cholangitis (PSC) is a long-term liver disease characterized by a progressive course of cholestasis with liver inflammation and fibrosis. Intestinal barrier dysfunction has been implicated in the pathogenesis of PSC. According to the “leaky gut” hypothesis, gut inflammation alters the permeability of the intestinal mucosa, with the translocation of gut-derived products that enter the enterohepatic circulation and cause hepatic inflammation. Thus, the administration of molecules that preserve epithelial barrier integrity would represent a promising therapeutic strategy. Indole-3-carboxaldehyde (3-IAld) is a microbial-derived product working at the interface between the host and the microbiota and is able to promote mucosal immune homeostasis in a variety of preclinical settings. Herein, by resorting to a murine model of PSC, we found that 3-IAld formulated for localized delivery in the gut alleviates hepatic inflammation and fibrosis by modulating the intestinal microbiota and activating the aryl hydrocarbon receptor-IL-22 axis to restore mucosal integrity. This study points to the therapeutic potential of 3-IAld in liver pathology.
|
2022-12-04T15:35:01.261Z
|
41,402,931 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1467-842X.1997.tb01718.x",
"MAG": "1991076753",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract: The workplace is an important setting, affecting the physical, mental, economic and social wellbeing of workers, and, in turn, their families. Health of workers has many determinants, and a multidisciplinary, integrated approach is important. An overview of trends in workplace health promotion shows that current thinking has changed from a narrowly based risk–factors approach aimed at individual behaviour changes, to an integrative approach aimed at creating health–promoting workplaces. The health–promoting workplace has ‘an all—encompassing approach that empowers workers and employers to improve all facets of their health’. There are gaps in knowledge, at the state and national levels, relevant to the planning and assessment of workplace health. A national information network is needed to facilitate better links between public health practitioners and researchers in advancing the health of working Australians.
|
2022-12-26T20:47:29.352Z
|