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255M
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93,681,410 |
{
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"DOI": "10.3788/FGXB20133409.1144",
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|
A new 4-aminoantipyrine-based Schiff-base(M) was synthesized.Its structure was characterized by using IR,1H NMR and elemental analysis.The influences of a number of different metal ions on its UV-Vis absorption and fluorescence spectral were studied in acetonitrile.Spectroscopic studies revealed that compound M could detect Cu2 +by UV-Vis absorption and fluorescence spectrophotometry.The stoichiometry ratio of M-Cu2 +was 1∶ 1,respectively.Moreover,the detection limit was calculated to be 1.41 μmol/ L for Cu2 +ion.The analysis suggested that M could behave as a fluorescent sensor for the selective detection of Cu2 +and the binding constant was 6.5 × 104L/ mol.Thus a new kind of chemosensor for Cu2 +with high sensitivity and selectivity was introduced.
|
2022-12-14T15:25:48.485Z
|
8,063,134 |
{
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"ArXiv": null,
"DOI": "10.1002/em.21680",
"MAG": "2112082498",
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"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc3520608?pdf=render"
}
|
Styrene–acrylonitrile Trimer (SAN Trimer), a by‐product in production of acrylonitrile styrene plastics, was identified at a Superfund site in Dover Township, NJ, where childhood cancer incidence rates were elevated for a period of several years. SAN Trimer was therefore tested by the National Toxicology Program in a 2‐year perinatal carcinogenicity study in F344/N rats and a bacterial mutagenicity assay; both studies gave negative results. To further characterize its genotoxicity, SAN Trimer was subsequently evaluated in a combined micronucleus (MN)/Comet assay in juvenile male and female F344 rats. SAN Trimer (37.5, 75, 150, or 300 mg/kg/day) was administered by gavage once daily for 4 days. Micronucleated reticulocyte (MN‐RET) frequencies in blood were determined by flow cytometry, and DNA damage in blood, liver, and brain cells was assessed using the Comet assay. Highly significant dose‐related increases (P < 0.0001) in MN‐RET were measured in both male and female rats administered SAN Trimer. The RET population was reduced in high dose male rats, suggesting chemical‐related bone marrow toxicity. Results of the Comet assay showed significant, dose‐related increases in DNA damage in brain cells of male (P < 0.0074) and female (P < 0.0001) rats; increased levels of DNA damage were also measured in liver cells and leukocytes of treated rats. Chemical‐related cytotoxicity was not indicated in any of the tissues examined for DNA damage. The results of this subacute MN/Comet assay indicate induction of significant genetic damage in multiple tissues of weanling F344 male and female rats after oral exposure to SAN Trimer. Environ. Mol. Mutagen. 2012. © 2012 Wiley Periodicals, Inc.
|
2022-12-14T23:41:08.187Z
|
253,496,019 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.52015/numljci.v20ii.218",
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"license": "CCBYNC",
"status": "GOLD",
"url": "https://jci.numl.edu.pk/index.php/jci/article/download/218/85"
}
|
This research seeks to investigate the language of female madness as the central trope of the decolonizing struggle against double colonization. Rhys’ female protagonist in Wide Sargasso Sea, Antoinette, is alienated and deprived of her original identity in race and class. The hegemonic process of colonial patriarchy embedded in the victimization of the female subject objectifies her through her double marginalization at the hands of colonial apparatus and patriarchy. Her decolonizing outburst against double colonization, when expressed through an unconventional language, is viewed as an act of madness by the society. This research routes its argument through the so-called sanity of a societal structure rooted in the dispensation of colonial atrocity which, as a consequence, gives rise to mental imbalance (madness) of the female protagonist. This study, located in the qualitative paradigm, develops its methodology on the qualitative grounds with an interpretive and exploratory design. It uses textual analysis as research method and deploys theoretical support from Postcolonial Feminism with a focus on ‘decolonization’ and ‘double colonization.’
|
2022-12-16T15:47:59.113Z
|
94,181,284 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/JE00017A044",
"MAG": "1967106338",
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"license": null,
"status": null,
"url": null
}
|
Excess molar volumes, V m E , for binary mixtures of eight aliphatic amino alcohols (2-aminoethanol 3-amino-1-propanol, 4-amino-1-butanol, 5-amino-1-pentanol, 2-amino-1-propanol, 1-amino-2-propanol, 2-amino-2-methyl-1-propanol, and 2-amino-1-butanol) with 1,4-dioxane have been determined from the density measurements at 293.1 K by means of a vibrating tube densimeter
|
2022-12-19T08:27:14.357Z
|
46,436,364 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/JF0511594",
"MAG": "2094314996",
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"license": null,
"status": null,
"url": null
}
|
Taste threshold tests of ferrous sulfate (FeSO4) solutions have been confounded by the presence of putative odorants. To detect the presence of odorants released from these solutions solid-phase microextraction (SPME) was used to collect volatiles in the headspace above FeSO4 solutions. Gas chromatography-olfactometry of samples collected over three time periods (1, 5, and 16 h) and at two temperatures (22 and 37 degrees C) revealed the presence of several metallic-smelling odorants in the headspace. Using authentic standards, two of the odorants were conclusively identified as 1-octen-3-one and 1-nonen-3-one. Trace levels of other odorants were also detected, but dilution experiments indicated that 1-nonen-3-one was at least 10 times more potent than anything else released from the solutions. 1-Octen-3-one and 1-nonen-3-one are excellent candidates for the metallic odor responses often observed in threshold testing of solutions of FeSO4.
|
2022-12-19T15:00:18.615Z
|
202,226,208 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/2053-1591/ab3e13",
"MAG": "2969991391",
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"url": null
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|
The diverse applications of gold nanoparticles (Au-NPs) with sizes less than 50nm require a comprehensive information about how to produce Au-NPs with different sizes and narrow size distributions for a desired application. In this work, a wide range of sizes of Au-NPs from 2.5 to 35nm has been synthesized by using two reducing agents of sodium citrate and sodium borohydride. We have studied the dependency of the size, polydispersity, surface potential, plasmonic spectrum, and pH of the resultant Au-NPs on the reducing agents’ concentrations. The findings show that uniform and monodispersed Au-NPs can only be produced in specific ranges of concentrations of the reducing agents. In addition, the absorption spectra of Au-NPs cannot uniquely determine the dominant size of the nanoparticles and polydispersity of the sizes is an important parameter. Measuring Zeta potential of the Au-NPs shows that by increment of pH of the solutions, the surface potential in both methods monotonically increases which results in more stability of the nanoparticles.
|
2022-12-25T23:04:02.421Z
|
114,078,410 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.20885/AJIE.VOL4.ISS1.ART7",
"MAG": "2512870999",
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},
"license": null,
"status": null,
"url": null
}
|
Desa Mitra (Partners Village) DPPM UII is the embodiment of catur dharma UII, which is a program of community development and rural area development based on thematic local potential and sustainable. DesaMitra program has been done a long time, but intensively measured and planned starting in 2006. Collaborative research with the community, the diffusion of science and technology, community service is a program developed in the DesaMitra program supported from internal funds UII, external funds DIKTI and / or CSR from various companies. To measure the achievement of the objectives and benefits of the DesaMitra program is needed evaluation and mapping studies. Evaluation includes the fruit-fullness of the program, the community understanding and their awareness for self-sustained. Evaluation by purposive random sampling of the dozens DesaMitra acquired 7 villages, namely: Sendangagung, Sendangsari, Wukirsari, Sindumartani, Cokrodiningratan, which is located in the district of Sleman and Yogyakarta municipality. The results obtained 5 villages to be developed in near future considered their potential has not been developed, high motivation from community and supportsother related program. The 2 villages postponed to be developed assessed effectiveness of development assistance program and the level of self-developed of its people. Keywords: evaluation, mapping, desamitra, mentoring, self-reliance
|
2022-02-10T01:53:05.778Z
|
22,151,954 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5606/kbbihtisas.2014.73554",
"MAG": "2320904293",
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},
"license": null,
"status": "CLOSED",
"url": null
}
|
OBJECTIVES
This study aims to evaluate the alterations in distances to the surgical margins on sheep tongue specimens, through resection, formalin fixation, frozen section, and microscopic examination.
MATERIALS AND METHODS
Fifty fresh sheep tongues were used in the study. A metal plate was fixed on the lateral aspect of each tongue to represent tumor tissues. A total of 40 specimens with either 1 cm or 2 cm distances as surgical safety margins of the surrounding plate were prepared using either scalpel or monopolar cautery (10 specimens were prepared for each group). Additional 10 specimens with 1 cm safety margins were prepared using either scalpel or monopolar cautery (5 specimens per group) for frozen section examination. Distances to the metal plates before resection were compared with the ones which were determined after resection, frozen section examination, 24-hour formalin fixation and microscopic examination.
RESULTS
Distances to the surgical margins were found to be decreased in all specimens after resection, 10% formalin fixation and microscopic examination. The distances to the surgical margins were observed to be reduced by 6.5-7.5% on average after resection, 10-12% on average after formalin fixation and 30% on average after microscopic examination, compared to the baseline values. The level of shrinkage was reduced by 6.3-10% following microscopic section preparation during frozen section examination.
CONCLUSION
Seven to eight-millimeter distance to the surgical margin at minimum should be maintained to achieve a 5 mm in height surgical safety margin during sheep tongue resection. The distance defined by the pathologist may be multiplied with 1.42 to estimate around in-situ distance to the surgical margins. Therefore, 1.42 may be used as a corrective factor for sheep tongue tissues.
|
2022-02-12T20:25:25.499Z
|
210,064,328 |
{
"externalids": {
"ACL": null,
"ArXiv": "2001.02612",
"DOI": "10.1109/ISIT44484.2020.9173946",
"MAG": "3000658051",
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"status": null,
"url": null
}
|
An adaptive joint source-channel coding (JSCC) scheme is presented for transmitting correlated sources over discrete-memoryless two-way channels subject to distortion constraints. The proposed JSCC scheme makes use of the previously transmitted and received channel signals as well as the sources’ correlation to facilitate coordination between terminals. It is shown that the adaptive scheme strictly subsumes prior lossy coding methods for two-way simultaneous transmission and yields a new adaptive separate source-channel coding result. Two examples are given to show the scheme’s advantages.
|
2022-12-03T20:19:10.519Z
|
61,893,066 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/30.24652",
"MAG": "2166458354",
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"license": null,
"status": null,
"url": null
}
|
The transmission characteristics of an installed power line used for data communication, and of a model of this actual line, were measured over the frequency range of 10 kHz-50 MHz. It was found that impedance characteristics were not greatly influenced by the working loads at high frequencies, but changed drastically at lower frequencies. For frequencies of less than 100 MHz, the transmission loss did not increase significantly with frequency. The effect of the length of the connections and variation in load impedance were both studied. It was found that for frequencies above 100 MHz, attenuation loss in the power line is divided into losses due to attenuation constant of the line and the loss occurring at wire connections located between the various wires in the wall sockets. The latter loss is proportional to the number of connections. When the transmission loss was measured by opening and closing the wire connections, the fluctuation in the loss was found to be smaller at frequencies above 1 MHz than at lower ones. The transmission loss at the higher frequency shows only fairly slight fluctuations to variations in working load on the power line. The intensity of the noise power spectrum shows a decrease of -40 B/decade. This degradation rate in the noise spectrum is greater than the rate of increase in transmission loss. The increasing transmission loss can be sufficiently compensated by amplification at the receiving end, but it is possible to keep the amplified noise below the level of disturbance. >
|
2022-12-16T08:15:45.330Z
|
5,145,083 |
{
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"ArXiv": null,
"DOI": "10.1152/jn.01114.2009",
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"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc2934937"
}
|
High-frequency burst neurons in the pons provide the eye velocity command (equivalently, the primary oculomotor drive) to the abducens nucleus for generation of the horizontal component of both head-restrained (HR) and head-unrestrained (HU) gaze shifts. We sought to characterize how gaze and its eye-in-head component differ when an "identical" oculomotor drive is used to produce HR and HU movements. To address this objective, the activities of pontine burst neurons were recorded during horizontal HR and HU gaze shifts. The burst profile recorded on each HU trial was compared with the burst waveform of every HR trial obtained for the same neuron. The oculomotor drive was assumed to be comparable for the pair yielding the lowest root-mean-squared error. For matched pairs of HR and HU trials, the peak eye-in-head velocity was substantially smaller in the HU condition, and the reduction was usually greater than the peak head velocity of the HU trial. A time-varying attenuation index, defined as the difference in HR and HU eye velocity waveforms divided by head velocity [alpha = (H(hr) - E(hu))/H] was computed. The index was variable at the onset of the gaze shift, but it settled at values several times greater than 1. The index then decreased gradually during the movement and stabilized at 1 around the end of gaze shift. These results imply that substantial attenuation in eye velocity occurs, at least partially, downstream of the burst neurons. We speculate on the potential roles of burst-tonic neurons in the neural integrator and various cell types in the vestibular nuclei in mediating the attenuation in eye velocity in the presence of head movements.
|
2022-12-19T17:59:14.453Z
|
33,058,580 |
{
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"ACL": null,
"ArXiv": "1708.07222",
"DOI": "10.4204/EPTCS.253.4",
"MAG": "2748332270",
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"url": null
}
|
We extend a technique called Compiling Control. The technique transforms coroutining logic programs into logic programs that, when executed under the standard left-to-right selection rule (and not using any delay features) have the same computational behavior as the coroutining program. In recent work, we revised Compiling Control and reformulated it as an instance of Abstract Conjunctive Partial Deduction. This work was mostly focused on the program analysis performed in Compiling Control. In the current paper, we focus on the synthesis of the transformed program. Instead of synthesizing a new logic program, we synthesize a CHR(Prolog) program which mimics the coroutining program. The synthesis to CHR yields programs containing only simplification rules, which are particularly amenable to certain static analysis techniques. The programs are also more concise and readable and can be ported to CHR implementations embedded in other languages than Prolog.
|
2022-12-23T02:08:29.171Z
|
38,641,825 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1467-842X.2000.tb01608.x",
"MAG": "2014110468",
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},
"license": null,
"status": null,
"url": null
}
|
Objectives: To collect smoking–related data from Chinese patients attending Chinese–speaking general practitioners (CSGPs), including self–reported smoking status, recall of a question about smoking status during the previous six months by their GP and, for smokers, their recall of quit advice in their most recent consultation.
|
2022-12-23T02:11:45.587Z
|
208,521,709 |
{
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"ArXiv": null,
"DOI": "10.1083/jcb.1754rr4",
"MAG": "2056546105",
"PubMedCentral": "2064585"
},
"license": null,
"status": "BRONZE",
"url": "https://rupress.org/jcb/article-pdf/175/4/518/1326592/jcb_1754rr.pdf"
}
|
Self reliance is not enough. Some organs rely on the kindness of others to control their size, according to Joseph Parker (Columbia University, New York, NY).
Figure 1
Too much EGF receptor signaling increases P compartment size (left). Too little reduces it (right).
Correct organ size is measured in mass, not cell numbers—forcing or blocking cell division generally does not change an organ's overall dimensions. Parker found the same is true in the fly embryonic P compartment, which forms part of the larval epidermis. Increases in P compartment cell numbers were countered by more apoptosis and smaller cells. With fewer numbers, on the other hand, each cell grew larger to accommodate for their missing comrades.
In looking for a molecular explanation, Parker figured it would make sense to “have size information encoded right there in the patterning system” that also controls cell fate and positioning. For the P compartment, these patterning molecules are extracellular ligands called Spitz and Wingless. The new results show that more or less Spitz signaling creates larger and smaller P compartments, respectively.
At the individual cell level, Spitz suppressed apoptosis and encouraged cell growth by activating the EGF receptor and downstream MAP kinase pathways. To explain how overgrowth is prevented, Parker reasoned that “the simplest model is that the level of Spitz is fixed in the compartment. More proliferation means less Spitz per cell.” Those cells thus grow less and are more susceptible to apoptosis.
Organs were previously thought to have autonomous control over their size. But the new model only works if Spitz is provided by an external source—otherwise, a bigger P compartment would make more Spitz and grow even larger. Although Spitz is expressed everywhere, it is activated solely in the neighboring A compartment, from where it apparently diffuses into the P compartment.
Because ligands such as Spitz are short-range diffusers, the model probably only applies to small or embryonic structures in the range of tens to hundreds of cells. “For larger organs like the liver,” Parker says, “diffusion is a rickety thing” that might require backup size control mechanisms.
Reference:
Parker, J. 2006. Curr. Biol. 16:2058–2065. [PubMed]
|
2022-02-08T03:52:36.313Z
|
161,408,414 |
{
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"ArXiv": null,
"DOI": "10.1080/07053436.2007.10707746",
"MAG": "2020666009",
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},
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}
|
Résumé La mondialisation est venue interroger, voire provoquer les sciences, notamment sociales, économiques et environnementales. Devant son emprise sur le globe, les sociétés sur leurs territoires, fondements de la vie quotidienne, ont réagi avec plus ou moins de vigueur pour affirmer leur personnalité, leurs droits inaliénables, exprimant ainsi leur territorialité. Le tourisme, l’un des grands destructeurs de l’environnement et des sociétés, participe à l’extraordinaire gâchis des ressources naturelles. Les chercheurs, mis en réseau disciplinaire et pluridisciplinaire, doivent être vigilants et prendre en compte, dans leur démarche, le respect des impératifs environnementaux, en particulier, et de l’éthique en général. La recherche et les réflexions touristiques visant les remèdes au gaspillage ont parmi leurs missions fondamentales celle d’étudier les moyens destinés à supprimer progressivement les pratiques qui portent atteinte au bon fonctionnement de notre planète.
|
2022-02-08T22:14:51.592Z
|
123,048,323 |
{
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"ArXiv": null,
"DOI": "10.1121/1.391051",
"MAG": "2086638871",
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},
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"status": null,
"url": null
}
|
A high resolution scanning beamformer for a soundhead having a circular or a cylindrical array of hydrophones uses charge coupled devices as transversal filters in a plurality of first stage quadrature sampled phase shift steered beamforming modules. In a second stage, serial-in/serial-out charge coupled devices are used to correct for fill time. The sonar focuses at all nearfield ranges of interest by controllably varying a clocking rate.
|
2022-02-09T18:50:05.874Z
|
131,582,576 |
{
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"ArXiv": null,
"DOI": "10.1111/J.1365-246X.1979.TB02554.X",
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}
|
Summary. Three principal directions of magnetization are recognized in the central part of the Lewisian metamorphic terrain of north-west Scotland. The first (‘A’) magnetization is a high blocking temperature component residing in magnetite and imposed during post-Laxfordian uplift and cooling. Fifty sites yield an overall mean D = 285.9°, I = 54.9° and palaeomagnetic pole at 273.2° E, 37.6° N (dp = 3.7°, dm = 5.2°); this magnetization was probably acquired at crustal depths of 6–10 km and is linked to K—Ar uplift ages averaging 1650–1625 Ma. The second (‘B’) magnetizations are defined by E—W directions and also reside in high blocking temperature components; they are, however, dipolar, have some properties distinct from the ‘A’ magnetizations, and are correlated with late stages in the history of the complex at 1400–1200 Ma. The third (‘C’) NE directed magnetizations reside predominantly in low blocking temperature components in pyrrhotite and possibly maghemite, and were probably acquired at a late stage of the regional uplift; they do not correlate with post-1450 Ma magnetizations from the Laurentian Shield and probably relate to the as yet undefined interval 1600–1450 Ma. The collective palaeomagnetic data and certain geologic data suggest that the Lewisian foreland should be rotated by 30° clockwise about a local axis of rotation on the conventional reconstruction of the North Atlantic continents; this rotation is associated with Lower Palaeozoic trans-current movements and may be related to a fourth (‘D’) magnetization of viscous origin.
A collective assessment of 1850–1600 Ma palaeomagnetic data for the Laurentian Shield defines a large apw loop; there is widespread agreement between data from the constituent structural provinces of the Shield although different metamorphic regions define complementary segments of the loop related to uplift over different intervals of time.
|
2022-08-20T01:57:35.280Z
|
236,330,172 |
{
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"DOI": "10.1200/JCO.2021.39.15_SUPPL.7538",
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},
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"status": null,
"url": null
}
|
Background: PTEFb/CDK9-mediated transcription of short-lived anti-apoptotic survival proteins and oncogenes like MCL-1 and MYC plays a critical role in a variety of cancers. VIP152 (formerly BAY 1251152), a potent and highly selective CDK9 inhibitor, has been evaluated in a Phase 1 dose-escalation study in patients with advanced cancer. The maximum tolerated dose was 30 mg once weekly administered in consecutive 21-day cycles, based on neutropenia as the dose-limiting toxicity (JCO 2018;36:2507;NCT02635672). DHL is defined as dual rearrangement of the MYC gene and either the BCL2 or BCL6 genes;the resulting overexpression of MYC and BCL2/BCL6 make it particularly difficult to treat. Patients with DHL have a poor prognosis and no standard of care. Considering the impact of CDK9 inhibition on MYC, an exploratory cohort of patients with DHL was added to the study. Methods: Patients with refractory or relapsed DHL were eligible. VIP152 was administered once weekly as a 30-minute IV infusion on Days 1, 8 and 15 of a 21-day cycle. Tumor response was assessed according to the revised Cheson criteria (2007). Results: To date a total of 7 patients have been enrolled and were evaluable at the time of data cutoff (24NOV2020). The patients were mostly men (6/7 pts, 86%) with a median (range) age of 70 (58-84) years. All patients received ≥2 prior therapies, including 2 patients with bone marrow transplant. Three of 7 patients (29%) had ≥3 prior therapies. The median time on treatment was 22 days (range 8-1361 days). The most common adverse events of any grade were: constipation, fatigue, nausea (each 3/7 pts, 43%) and abdominal pain, diarrhea, lymphocyte count decrease, neutrophil count decrease, skin infection, tumor pain, and vomiting (each 2/7 pts, 29%). Most were Grade 1 and Grade 2. The Grade 3 adverse events were fatigue, lymphocyte count decrease, neutrophil count decrease (each 1/7 pts, 14%) and tumor pain (2/7 pts, 29%). One Grade 4 lymphocyte count decrease was reported. Two patients had a serious adverse event (Grade 3 syncope and Grade 3 tumor pain). Two patients had dosing held for an adverse event;however, no patient withdrew from treatment due to any adverse events. One death occurred due to disease progression. Pharmacodynamic biomarker analysis showed significant reduction of MYC, PCNA, and MCL-1 mRNA in all patients across multiple timepoints. Antitumor activity consisted of 2 complete metabolic responses in 7 patients (29%) based on investigator-assessed FDG-PET scans. Due to the COVID pandemic, the patients withdrew consent after 3.7 and 2.3 years, respectively, of treatment. Both patients were in complete metabolic response. Conclusions: VIP152 had a manageable safety profile, on-target pharmacodynamic activity and signs of durable monotherapy antitumor activity in patients with DHL. These encouraging results warrant further evaluation of VIP152 in patients with MYCdriven lymphoma and solid tumors.
|
2022-09-06T17:10:57.994Z
|
96,566,629 |
{
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"ArXiv": null,
"DOI": "10.1002/CMR.A.20159",
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"url": null
}
|
The two-dimensional nuclear magnetic resonance correlation spectroscopy (2D NMR COSY) spectrum of an AX spin system of spin-1 has been calculated by numerical density matrix calculations. The mathematical expressions found are valid for an AX spin system of any spins. These expressions should be used to calculate the 2D NMR COSY spectrum of an AX spin system of high spin nuclei as their use will significantly simplify the calculations. More precisely, one needs to calculate only one set of coefficients despite the need of two steps in the phase cycling to achieve phase modulation during t1. © 2010 Wiley Periodicals, Inc. Concepts Magn Reson Part A 36A: 170–177, 2010.
|
2022-09-11T01:25:51.486Z
|
11,823,497 |
{
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"DOI": "10.1093/HSW/34.1.8",
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"status": null,
"url": null
}
|
This study addresses the factors influencing decisions to send medicine-surgical (med-surg) patients home or to nursing facilities (NFs). The sample (n = 7,852) was taken from a large, urban, teaching, med-surg unit where discharges were documented and data collected over a two-and-a-half-year period. Using logistical regression, the factors found to most influence the decision were age (z = 26.99, p = .000; odds = 1.06); patients diagnosed with "musculoskeletal system" problems (z = 11.07, p = .000; odds = 5.36); and needing skilled professional care (z = -15.03, p = .000; odds = .21) or nonprofessional personal care (z = 6.62,p = .000; odds = 2.32). Having less effect, but important information for discharge planners, was being an African American (z = 3.82, p = .000; odds = .76) or Latino (z = -3.96, p = .000; odds = .54). A review of the literature found limited knowledge of the factors that influence hospital patients, family members, and professionals, including social workers, to make the decision to recommend home care or NF care.
|
2022-09-14T17:18:24.355Z
|
158,014,289 |
{
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"DOI": "10.14710/JPPMR.V6I2.14851",
"MAG": "2598070415",
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},
"license": null,
"status": null,
"url": null
}
|
Tourism Sector is a sector that assessed the potential to be developed in an effort to increase revenue for the region through tourist attraction. Kedungsepur region has a percentage of the number of tourists both from domestic and international amounted to 19.31% in 2013 and 20.34% in 2014, but its range is not evenly distributed. So that the tourism sector included in the priority scale Inter-regional Cooperation Kedungsepur area approved by the respective Regional Head in 2011. Research method uses descriptively qualitative research design with observation, interview, and literary review as the data collecting technique. The information source are Culture Division Head of Culture and Tourism Department of Semarang, Chief of Local Government and International relation of Semarang Municipality, and Destinations Section Staf Culture and Tourism Department of Central Java Province. The research result that implementation of Inter-regional Cooperation in tourism Kedungsepur region not fully accomplished, proven by the implementation of Inter-regional Cooperationin tourism Kedungsepur have found problems at every stage. When on interpretations phase, there are some issues because each area is not tourism as a major sector for each region, as well as at the application phase there are problems regarding the implementation is not accordance with the planning. Recommendation can be done to improve implemention for Inter-regional Cooperation of Kedungsepur region in tourism is need to increase the commitment of each parties that involved in cooperation, unify the understanding of each region on cooperation in tourism, also need some in-depth review of strategy to promote single destination.
|
2022-11-28T17:25:51.274Z
|
252,327,906 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.19137/praxiseducativa-2022-260314",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://doi.org/10.19137/praxiseducativa-2022-260314"
}
|
The present work deals with the youth transitions of young mothers, mediated by a state device such as municipal kindergartens, which open possibilities for them in terms of trajectory. The results of a study carried out through interviews with directors of municipal gardens and young mothers who attend them are presented, through a qualitative methodology that combined virtual and face-to-face interviews. The information collected was processed considering the most important variables of the survey. From its analysis, the main results are presented. The article also reviews the current situation of the initial level, showing the inequality in access to this level by the most vulnerable sectors, describes the network of kindergartens in Avellaneda and presents a theoretical framework for the analysis of the interviews. mentioned. Finally, it offers final comments to continue the theoretical discussions. Keyword: juventud; transiciones; educación; género; sistemas de cuidado.
|
2022-12-07T14:42:58.505Z
|
31,039,145 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1902/JOP.2001.72.5.666",
"MAG": "2120287328",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Tobacco smoking has been identified as one major risk factor for destructive periodontal disease. Scaling and root planing have been shown to be less effective in smokers with periodontitis. The aim of the present study was to compare the subgingival microbial flora of treated and untreated smokers and non-smokers.
METHODS
Four independent adult patient groups with periodontitis were included in this investigation: 88 untreated smokers (U-S); 90 untreated non-smokers (U-NS); 119 treated non-smokers (T-NS); and 171 treated smokers (T-S). Clinical variables included cumulative plaque index (CPI), probing depth (PD), clinical attachment level (CAL), cumulative bleeding index (CBI), and cumulative suppuration index (CSI). Paper point samples from the deepest bleeding pocket in each quadrant of the dentition were analyzed for the presence and levels of 6 periodontal bacterial pathogens using anaerobic culture techniques.
RESULTS
U-S showed a higher mean cumulative plaque index than U-NS (3.5 versus 2.7). Mean PD and mean CAL were higher in the T-S in comparison to the T-NS group (7.0 versus 6.6 mm and 5.6 versus 4.7 mm, respectively). Microbiological characteristics of U-S were a higher prevalence of Prevotella intermedia/nigrescens and higher mean levels of Peptostreptococcus micros (Pm) and Fusobacterium nucleatum (Fn). T-S patients were characterized by higher prevalence of Bacteroides forsythus (Bf), Pm, and Campylobacter rectus (Cr) and higher mean levels of Pm and Fn. The mean percentage of B. forsythus tended to be higher in the T-S group than in the T-NS group (6.9% versus 5.6%). The relative risk to be infected with Bf, Pm, and Cr was statistically higher in smokers (odds ratios: 1.9, 1.9, and 1.6, respectively). The chance to find > or =10% of Bf, Pm, and/or Fn was 3.3 higher in smokers when A. actinomycetemcomitans and P gingivalis were absent. Detection of > or =20% Pm/Fn in treated patients was strongly associated with smoking (odds ratio 13.8, P= 0.002).
CONCLUSIONS
Smoking is a determining factor for the composition of the subgingival microflora in adult patients with periodontitis and may select for a specific cluster of periodontal pathogens, notably Bf, Pm, Fn, and Cr. On the basis of these observations, smoking, among other criteria, may be one parameter to use in deciding to treat refractory periodontitis in smokers with a systemic antibiotic therapy directed against smoking-associated periodontal bacteria.
|
2022-12-14T17:49:59.643Z
|
2,960,401 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1467-9280.2008.02109.x",
"MAG": "2168734411",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We assessed the extent to which implicit proactive interference results from automatic versus controlled retrieval among younger and older adults. During a study phase, targets (e.g., “ALLERGY”) either were or were not preceded by nontarget competitors (e.g., “ANALOGY”). After a filled interval, the participants were asked to complete word fragments, some of which cued studied words (e.g., “A_L__GY”). Retrieval strategies were identified by the difference in response speed between a phase containing fragments that cued only new words and a phase that included a mix of fragments cuing old and new words. Previous results were replicated: Proactive interference was found in implicit memory, and the negative effects were greater for older than for younger adults. Novel findings demonstrate two retrieval processes that contribute to interference: an automatic one that is age invariant and a controlled process that can reduce the magnitude of the automatic interference effects. The controlled process, however, is used effectively only by younger adults. This pattern of findings potentially explains age differences in susceptibility to proactive interference.
|
2022-12-23T21:27:36.786Z
|
218,490,406 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/ppc.12517",
"MAG": "3022258242",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1111/ppc.12517"
}
|
PURPOSE
This cross-sectional study examined the cyber-psychological correlates of depression, anxiety, stress, and suicidality among public university students in Klang Valley, Malaysia.
DESIGN AND METHODS
Participants were randomly selected using multi-stage sampling methods from three public universities in the study location. Participants completed measures of internet and smartphone addictions, depression, anxiety, stress, and suicidality, along with sociodemographic items.
FINDINGS
At bivariate level, both internet and smartphone addictions were found to have significant positive correlations with depression, anxiety, stress, and suicidality. At multivariate level, only internet addiction emerged as a consistent significant predictor for depression, anxiety, stress, and suicidality.
PRACTICE IMPLICATIONS
The present findings have implications for mental health professionals to routinely screen for psychological disturbance in young adults who have potential risks for internet addiction.
|
2022-12-31T05:15:39.722Z
|
151,445,012 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1024/1662-9647/A000160",
"MAG": "2558123368",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract. Research on aging in different domains largely focuses on age-related decrements or intervention-related improvements, often in controlled laboratory conditions or with psychometric tests of maximum ability or traits. This special issue on monitoring and promoting old-age health stabilization in real life focuses on the short-term and long-term age-related stabilization and maintenance in diverse psychological areas, including well-being, self-esteem, subjective health, and social interactions. One central focus in all studies is the clear focus on behaviors in real-life contexts. The papers both review and present ways in which new technologies and research approaches can provide novel opportunities for monitoring and promoting the stabilization of various aspects of health and quality of life in the daily lives of healthy older adults.
|
2022-02-09T03:22:57.345Z
|
187,402,030 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/9783486790962-001",
"MAG": "2765862251",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Der vorliegende Band hat bereits drei Auflagen in kurzen zeitlichen Abständen erlebt, dann aber „eine Pause eingelegt“. In dieser Zeit ist die Bedeutung des Themas Kundenwert eher gestiegen als gesunken. Die Bewertung von Kunden aus der Perspektive eines Anbieters und die Bewertung aller Geschäftsbeziehungen haben unter dem Stichwort „Relationship Management“ bzw. „Relationship Marketing“ einen noch höheren Stellenwert in der Wirtschaftspraxis und auch in Forschung und Lehre erfahren. Der Umgang eines Anbieters mit einzelnen Kunden und Kundensegmenten wird inzwischen weithin als Kundenmanagement diskutiert und auch in der akademischen Lehre und Forschung durch vielerlei Analysen und Publikationen gewürdigt. Zudem hat das so genannte „wertorientierte Management“ weiter an Bedeutung gewonnen und ist in verschiedenen Bereichen der Betriebswirtschaftslehre eine präferierte Denkweise. In der dritten Auflage dieses Bandes mit einer Zusammenstellung unterschiedlich ausgerichteter Beiträge haben wir konstatiert, dass es noch weiße Flecken auf der Landkarte der Kundenwert-Thematik gibt. Wir haben versucht, einige der Lücken zu schließen. Insbesondere sind mit fortschreitender Digitalisierung und Online-Aktivitäten Kunden-LieferantenBeziehungen via digitaler Kommunikation und zum Teil auch digitaler Lieferung voll etabliert und erfassen immer weitere Bereiche. Darauf nehmen einige der neuen und der überarbeiteten Beiträge Bezug. Die Herausgeber der früheren Auflagen, Bernd Günter und Sabrina Helm, haben sich entschieden, mit Prof. Dr. Andreas Eggert, Universität Paderborn, einen renommierten Marketing-Kollegen um Mitwirkung zu bitten. Dieser ist mit größtem Engagement – auch seines Teams – in das Projekt eingestiegen und verantwortet nun die vierte Auflage mit. Wir danken allen an der vierten Auflage Beteiligten nachdrücklich. Besonderer Dank gilt den neu hinzugekommenen Autorinnen und Autoren sowie auch jenen, die mit ihren Beiträgen bereits in den früheren Auflagen vertreten waren und durch ihre Überarbeitungen an der Weiterentwicklung des Bandes ihren Anteil haben. Außerdem bedanken wir uns nachdrücklich bei Frau Andrea Hampel, Paderborn, und bei cand. rer. pol. Constanze Geishauser, die die organisatorischen Aktivitäten wesentlich mitgetragen haben und die technische Bearbeitung der vierten Auflage vorgenommen haben. Mit der nun vorliegenden vierten Auflage wird die Erschließung und Akzentuierung des Kundenmanagements und damit besonders der Bewertung von Kundenbeziehungen vertieft
|
2022-07-01T04:31:49.786Z
|
123,592,072 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/NME.702",
"MAG": "2096069491",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An indirect time‐domain boundary element method (BEM) is presented here for the treatment of 2D elastodynamic problems. The approximated solution in this method is formulated as a linear combination of a set of particular solutions, which are called bases. The displacement and stress fields of a basis are analytically derived by means of solving Lame's displacement potentials. A semi‐collocation method is proposed to be the time‐stepping algorithm. This method is equivalent to a displacement discontinuity method with piecewise linear discontinuities in both space and time. The resulting time‐stepping scheme is explicit. The BEM is implemented to solve three numerical examples, Lamb's problem, half‐plane with a buried crack and Selberg's problem. Though Lamb's problem is considered a difficult problem for numerical methods, the current numerical results for the surface displacements show accurately the characteristics of the Rayleigh wave. This method is efficient and accurate. Copyright © 2003 John Wiley & Sons, Ltd.
|
2022-08-25T06:37:19.343Z
|
121,195,060 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVB.67.115314",
"MAG": "2046761561",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The adsorption and reaction of cyclopentene on the Ge(001) surface is investigated by first-principles density-functional calculations within the generalized gradient approximation. Surprisingly, a recent cluster calculation for adsorbed cyclopentene on Ge(001) obtained an adsorption energy of 2.10 eV. which is larger than the same cluster result (1.65 eV) on Si(001). However, our calculated adsorption energy for 0.5(1)-monolayer cyclopentene on Ge(001) is 0.79(0.51)eV, comparable with an observed activation energy of 0.7 eV for desorption. In addition we find that the energy barriers for the adsorption of cyclopentene on Ge(001) and Si(001) not only depend on cyclopentene coverage but also quantitatively differ from each other. Based on the calculated energy profile for the reaction we discuss the experimental observations of the difference between cyclopentene sticking on the Ge(001) and Si(001) surfaces.
|
2022-08-28T23:54:01.442Z
|
31,954,502 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1258/rsmsmj.55.3.22",
"MAG": "2321879992",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background & Aims The incidence of Crohn's disease (CD) in northeastern Scotland was last reported as rising in the 1980's, while in the rest of Europe it had reached steady state. This study reviewed the incidence of CD in NHS Tayside. Methods Data was collected retrospectively and analysed using age and sex standardization, socioeconomic factors and urban and rural postcodes. Results A point prevalence of 157 per 100,000 population in the Tayside region was found. The average incidence of CD was 9.56 per 100,000 per year between 2003 and 2007 and 7.16 per 100,000 per year between 1998 and 2001. There was no link to urbanization and no difference in incidence between the sexes. Incidence was not related to affluence in this population and peak age of onset occurred in the third decade of life only. 12.7% of patients had a family history of inflammatory bowel disease and 25% of patients were current smokers. Conclusions The incidence of CD appears to have arrived at a steady state in Tayside, while recent evidence suggests that it is on the rise in Scandinavia again. The results of the genetic studies to come from the east of Scotland are eagerly awaited to help shed light on the aetiology of this complex disorder.
|
2022-09-28T15:59:48.669Z
|
84,333,597 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1365-2621.2005.01042.X",
"MAG": "2004822918",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Summary
Esters are quite important for the aroma of aged red wine as they contribute to the fruity complex nature of this wine. This research paper measured the development of esters during maturation of Merlot red wines. These wines had different amounts of turbidity. The wine was aged for 18 months either after filtration with diatomaceous earth or without filtration. Both American and French oak barrel were used for storage. The results obtained showed that the unfiltered wine had a greater concentration of esters at the end of the storage period than the filtered wine. Fatty acid and ethanol esters decreased more than isoamyl acetate, independently of filtration. Ethyl octanoate and ethyl decanoate decreased both in filtered and unfiltered wine. Isoamyl acetate was formed in unfiltered wine and ethyl butyrate and ethyl hexanoate decreased in filtered wine while they remained constant in unfiltered wine.
|
2022-10-22T18:21:48.720Z
|
182,754,892 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/JFS.12665",
"MAG": "2945382182",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Listeria monocytogenes is a major foodborne pathogen that may contaminate liquid egg yolk (LEY). A background microbiota, purified and identified as Enterococcus faecium with a 99.0% probability, was found in pasteurized unsalted LEY. This study was conducted to investigate the thermal resistance of L. monocytogenes and the background microbiota in unsalted and 10% salted LEY at temperatures between 55 and 67.5°C. Both Weibull model and linear survival model were used to analyze the survival curves. Data analysis showed that the thermal resistance of E. faecium was not affected by the addition of 10% salt in LEY, and it was almost two orders in magnitude higher than that of L. monocytogenes in unsalted LEY. Adding 10% salt to LEY significantly elevated the thermal resistance of L. monocytogenes to the level of E. faecium. It can be concluded that the heating conditions used to inactivate L. monocytogenes or Salmonella Enteritidis would not be able to kill E. faecium if it is found in unsalted LEY, while similar heating conditions can be used to kill both L. monocytogenes and E. faecium in 10% salted LEY. The results of this study may be used to design adequate heating conditions to inactivate L. monocytogenes and E. faecium in LEY. PRACTICAL APPLICATIONS: Salted liquid egg yolk (LEY) contaminated with L. monocytogenes may require higher temperature or longer time to process. This study determined the thermal processing conditions that may be required to inactivate L. monocytogenes. The results attained from this study may be useful to the food industry that uses 10% salted LEY in the products.
|
2022-12-18T23:53:32.521Z
|
152,194,443 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15613/HIJRH/2016/V3I1/111733",
"MAG": "2514358549",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Working women are challenged by work and family commitments on each day in all the careers. Women working through-out the week are struggling to balance their family and work commitments. When a woman is able to manage her personal and professional life she becomes more committed to her office work. As a result, she is able to achieve success in her career. Further, it will also help her in leading a healthy and peaceful life. Nurses play the major role in health care and thus it is necessary that their needs have to be taken care and a congenial atmosphere is to be created to work with utmost satisfaction. Therefore, the concept of Work-Life Balance along with its implications is a core issue that must be investigated. Married Female nurses struggle with highly demanding familial, personal and societal duties to be performed in their day-to-day life. Any imbalance in their life causes job and family stress leading to health related problems. In order to understand the work-life balance challenges and the various conflict factors influencing the work-life balance, the present study has been proposed to be undertaken. A sample of 200 married female nurses working in Private and Government Hospitals in Erode District were selected and a structured questionnaire was used to collect the information from the respondents. A factorial model has been applied to identify the major work-life conflict factors by KMO Bartlett’s Validity test and the Correlation Matrix. The Principal Component Analysis method was also applied to extract the major factors by Varimax rotation. The variables identified are the vital factors which can be concentrated on more by the female nurses in order to avoid work-life conflicts to ensure a balanced life.
|
2022-02-09T02:59:57.627Z
|
51,826,366 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/CHIN.197728146",
"MAG": "2322823498",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the reaction of phenylhydrazine with n-benzylpenilloic acids (Ia or Ila) n-penicillamine was obtained in high yield and purity. The lack of reactivity of N-acyl derivatives (Ib or Ub) with phenylhydrazine indicated that the above reaction proceeded through the open chain imine tautomer of Ia or Ila (IV). The epim~risation of n-benzylpenilloic acid (Ia and Ha) in aprotic solvents was studied by using PMR spectroscopy.
|
2022-02-11T22:46:28.899Z
|
69,476,608 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/cpe.4775",
"MAG": "2889756108",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Return‐Oriented Programming (ROP) attacks become very popular in recent years as these attacks can bypass traditional defense mechanisms such as data execution prevention (DEP) effectively. Previous solutions suffer from limitations in that: 1) some methods need to modify the target programs; 2) some methods introduce considerable performance cost; 3) some methods rely on the special hardware; and 4) ,most of existing methods could not provide an online protection for the target processes. In this paper, we present OnRop, an on‐the‐fly ROP attack protection system by using the commodity hardware features and OS internal facilities. Our system is compatible with the existing programs, and its protection layer can be added on demand. The experiments show that OnRop can detect ROP attacks effectively with moderate performance cost.
|
2022-09-04T12:15:17.913Z
|
42,898,131 |
{
"externalids": {
"ACL": null,
"ArXiv": "1510.00885",
"DOI": "10.1109/JPHOT.2017.2761779",
"MAG": "2963140000",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the optically pumped systems, the spin polarization of the atoms is generally derived by employing additional modulations, in which way an extra perturbation will be introduced and thus affect the normal operation of the sensors. By investigating the absorption principle of the circularly polarized pump laser, here, we demonstrate the feasibility of extracting the electron-spin polarization from the transmitted intensity of the pump beam. This scheme can detect real-time polarization without disturbing the normal operation of the sensor, and the experimental result agrees well with the theory. This research is of value to the research and development of optically pumped systems, especially the magnetometer, and the comagnetometer operated in the spin-exchange relaxation free regime.
|
2022-10-06T17:34:37.738Z
|
29,457,328 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/SLA.0b013e3181b5d61c",
"MAG": "2068332361",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective:To review the relative efficacy of intermittent pneumatic compression (IPC) and graduated compression stockings (GCS) stated in direct clinical comparisons. Summary Background Data:Both IPC and GCS are recommended for deep vein thrombosis (DVT) prophylaxis in surgical patients. Although both are known to be effective, guidance is less clear on the clinical grounds for choosing between the 2 devices. Methods:Major medical databases were searched for trial reports published between January 1970 and August 2008. All trials comprising a direct clinical comparison between IPC and GCS were reviewed. Results:Ten direct comparisons were found, 9 of which were with surgical patients. The difference in DVT outcome only reached statistic significance in 3, all of which showed IPC to have the lower DVT rate. Five of the trials that did not produce statistic significance included fewer than 40 patients in each study group. The crude cumulated DVT rate for all the trials was 5.9% for GCS and 2.8% for IPC. Conclusion:There is only weak evidence to show a difference in performance between the devices, however, given the many influential factors, caution should be taken in assuming equivalence.
|
2022-12-17T01:18:42.051Z
|
208,567,896 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1101/790626",
"MAG": "2979791675",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GREEN",
"url": "https://www.biorxiv.org/content/biorxiv/early/2019/10/08/790626.full.pdf"
}
|
Myeloproliferative neoplasms (MPNs) are blood cancers characterized by excessive production of mature myeloid cells that result from the acquisition of somatic driver mutations in hematopoietic stem cells (HSCs)1. While substantial progress has been made to define the causal somatic mutation profile for MPNs2, epidemiologic studies indicate a significant heritable component for the disease that is among the highest known for all cancers3. However, only a limited set of genetic risk loci have been identified, and the underlying biological mechanisms leading to MPN acquisition remain unexplained. Here, to define the inherited risk profile, we conducted the largest genome-wide association study of MPNs to date (978,913 individuals with 3,224 cases) and identified 14 genome-wide significant loci, as well as a polygenic signature that increases the odds for disease acquisition by nearly 3-fold between the top and median deciles. Interestingly, we find a shared genetic architecture between MPN risk and several hematopoietic traits spanning distinct lineages, as well as an association between increased MPN risk and longer leukocyte telomere length, collectively implicating HSC function and self-renewal. Strikingly, we find a significant enrichment for risk variants mapping to accessible chromatin in HSCs compared with other hematopoietic populations. Finally, gene mapping identifies modulators of HSC biology and targeted variant-to-function analyses suggest likely roles for CHEK2 and GFI1B in altering HSC function to confer disease risk. Overall, we demonstrate the power of human genetic studies to illuminate a previously unappreciated mechanism for MPN risk through modulation of HSC function.
|
2022-12-28T20:07:50.059Z
|
25,959,765 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1902/JOP.1987.58.7.481",
"MAG": "2073265338",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The effect of storage media, which are routinely used in replantation, upon the proliferative capacity of periodontal ligament fibroblasts, was compared with the effect of a tissue culture medium. The periodontal tissue was obtained from mandibular central incisors of White New Zealand rabbits. The experiments were performed in fibroblasts derived during second subculture. The storage media were physiologic salt solution, Ringer's solution and Rivanol; the tissue culture medium was alpha-minimum essential medium without nucleosides. The incubation period was 1 hour. [3H]-thymidine incorporation and cell counts were taken to indicate changes in the proliferative capacity of the fibroblasts. The tissue culture experiments showed that the proliferative ability of the periodontal ligament fibroblasts was dependent upon the composition of the storage medium. Physiologic salt solution, Ringer's solution and Rivanol were unable to maintain the metabolism of the fibroblasts. alpha-MEM medium, however, was capable of stimulating proliferation of the periodontal ligament fibroblasts.
|
2022-04-29T19:50:20.851Z
|
234,594,445 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22271/tpi.2020.v9.i12d.5444",
"MAG": "3113557750",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://www.thepharmajournal.com/archives/2020/vol9issue12/PartD/9-12-6-709.pdf"
}
|
The population of a human settlement in an area depends on the water availability and water pollution of that area. The paper aims to explain the relationship among them with a new law and give a mathematical formula for calculating the relation. The range of physico-chemical parameters of the water bodies are temperature (14.8 °C-17 °C), pH (6.05-7.4), alkalinity (115.5 mg/L-122.5 mg/L), total hardness (40 mg/L-167 mg/L), chloride (23.5 mg/L-118 mg/L), DO (4.6 mg/L-17.2 mg/L), TDS (49 mg/L-580 mg/L). The study revealed that parameters of water samples from uninhabited areas were within the permissible limit given by BIS (2012) and WHO (2017). But the pH, DO and TDS values of the water samples from inhabited areas were not within the permissible limit.
|
2022-06-18T15:23:33.149Z
|
80,514,634 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14813/IBRA.2017.91",
"MAG": "2794982586",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The number of stroke patients has increased year by year in many countries, as the population ages and fewer babies are born. Most of stroke patients require a rehabilitation after the onset of stroke. Many researchers and companies in most of countries have been studying new rehabilitation systems. The systems include the approach of Brain Machine Interface (BMI), rehabilitation supported robot and so on. It seems that those systems target at higher socioeconomic group in wealthy countries. Since the stroke patients are not necessarily wealthy, it is necessary to make other solution for the non-wealthy groups. Biophilia Rehabilitation Academy (BRA) in Japan have been constructing the new rehabilitation system with easy and cheap devices, which is so-called “Takizawa method”. The proposed method enable that the burden of PT will decrease by contrast of the traditional method, since one physical therapist (PT) treats several rehabilitation patient. In the future rehabilitation, each patient will select a favorite solution among many rehabilitation systems.
|
2022-06-18T22:58:21.314Z
|
35,215,781 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/nl801841r",
"MAG": "2041738076",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Core-shell structural MWNT/ZrO2 nanocomposites were successfully prepared by one-step hydrolyzing of MWNT-dispersed ZrOCl2.8H2O aqueous solution. A highly conformal and uniform monoclinic zirconia coating was deposited on MWNTs by this new and simple method, and the thickness of the coating increased with the reaction time.
|
2022-12-13T06:03:11.641Z
|
155,235,223 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22459/AG.21.01.2014.05",
"MAG": "2237712456",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The argument by Piketty and others that there is growing inequality and this is causing damage is not new. But regardless of who is running this argument, it is significantly flawed. The poor have definitely improved their situation, especially if taxes and income support are included, in many countries in the developing world and the US. A focus on inequality to the exclusion of poverty glosses over the large successes over recent decades. It paints a false picture of decline when large improvements have occurred.To the extent there have been increases in executive wages, this has probably been driven by technology and globalisation, not by poor corporate governance. And the returns to wealth being (relatively) high should be expected given the riskiness of owning wealth, and is actually necessary to ensure that investment occurs.Piketty’s (implied) argument that investment is bad should be dismissed out of hand, as should his argument that high taxes are required on wealth. Instead, the problems generated by ‘unfairly’ acquired wealth should be addressed by removing rents. Policymakers should consider broadening the ownership of capital and assisting those who are in genuine need, and reject proposals that pander to envy.
|
2022-12-15T16:09:07.841Z
|
247,420,210 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.52711/2349-2996.2022.00026",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Introduction: Covid-19 is an international public health emergency unprecedented in modern history and it causes several health and psychological problems among general population including high level of anxiety, depression and stress. The study was aimed to assess the psychological problems among young adults due to Covid 19. Research Methodology: A descriptive study was conducted at selected Panchayath of Alappuzha District, with the sample size of 50. Samples were selected through Non probability sampling technique using convenient sampling method. Data’s were collected by structured questionnaire, which comprises socio demographic variables, questions to assess the psychological well-being. Results: The study findings reveals that among 50 samples, majority of the subjects have moderate psychological problems (62%), remaining 38% percentage have mild psychological problems and none were affected severely. Conclusion: The current study findings concluded that there is high prevalence of psychological problems among young adults due to Covid 19 which emphasize the need for the health professionals including nurses to plan for the strategies to help the young adults to cope with the problems effectively.
|
2022-12-22T18:00:06.707Z
|
27,425,481 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4103/0259-1162.207072",
"MAG": "2620341657",
"PubMedCentral": "5594794"
},
"license": "CCBYNCSA",
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc5594794"
}
|
Introduction: Anesthetists come in contact with more than two-third of hospital patients. Timely referral to anesthetists is vital in perioperative and remote site settings. Delayed referrals, improper referrals, and referrals at inappropriate levels can result in inadequate preparation, perioperative complications, and poor outcome. Methods: The self administered paper survey to delegates attending anesthesia conferences. Questions were asked on how high-risk, emergency surgical cases remote site and critical care patients were referred to anesthetists and presence of rapid response teams. Results: The response rate was 43.8%. Sixty percent (55.3–64.8, P - 0.001) reported high-risk elective cases were referred after admission. Sixty-eight percent (63.42–72.45, P - 0.001) opined preoperative resting echocardiographs were useful. Six percent (4.16–8.98, P - 0.001) reported emergency room referral before arrival of the patient. Twenty-five percent (20.92–29.42, P - 0.001) indicated high-risk obstetric cases were referred immediately after admission. Consultants practiced preoperative stabilization more commonly than residents (32% vs. 22%) (P - 0.004). For emergency surgery, resident referrals occurred after surgery time was fixed (40% vs. 28%) (P - 0.012). Residents dealt with more cases without full investigations in obstetrics (28% vs. 15) (P = 0.002). Remote site patients were commonly referred to residents after sedation attempts (32% vs. 20%) (P = 0.036). Only 34.8 said hosptals where tbey practiced had dedicated cardiac arrest team in place. Conclusions: Anesthetic departments must periodically assess whether subgroups of patients are being referred in line with current guidelines. Cancellations, critical incidents and complications arising out of referral delays, and improper referrals must be recorded as referral incidents and a separate referral incident registry must be maintained in each department. Regular referral audits must be encouraged.
|
2022-01-27T10:16:43.173Z
|
236,477,560 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5220/0010530000750086",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://doi.org/10.5220/0010530000750086"
}
|
We propose a new digital signature scheme based on combining cryptographic timestamping with an endorsement scheme, both of which can be constructed from one-way and collision-resistant hash functions. The signature scheme is efficient and allows balancing of key generation and signing time for signature size and verification time. The security analysis is based on a realistic model of timestamping. As part of our construction, we introduce the novel concept of endorsements, which may be of independent interest.
|
2022-01-27T11:26:46.126Z
|
136,901,963 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/PEN.10673",
"MAG": "1973481391",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Using Aben's approach to three-dimensional photoelasticity, a method for the determination of the stress tensor in a transparent matrix around an isolated axisymmetric inclusion is detailed. The method is useful for studies on a microscopic scale, the inclusion preferably above 10 to 20 µm in diameter, especially when the total retardation is below the first fringe order of isochrom. The polarization and phase data for normal and oblique light beams are necessary for full determination of the stress tensor, including the information on pressure. The analysis is nondestructive of the composite material studied.
|
2022-02-09T10:54:08.368Z
|
11,899,934 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/026119291103900407",
"MAG": "2396523751",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
The 2010 Statistics of Scientific Procedures on Living Animals showed that the level of animal experimentation in Great Britain continues to rise, with just over 3.7 million procedures being conducted. This is almost exclusively due to the sustained increase in the breeding and utilisation of genetically-altered animals. Here, the general trends in the species used and the numbers and types of procedures are reviewed. In addition, the impact of the recent Government announcement to ban testing of household products on animals is discussed, along with the implications of the fish becoming the second most-frequently used animal in scientific research. Finally, concerns about primate use, the REACH System, cosmetics testing and the new EU Directive on the protection of laboratory animals are explained.
|
2022-02-13T04:52:35.043Z
|
169,783,755 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.26760/jrh.v2i1.2041",
"MAG": "2884037614",
"PubMedCentral": null
},
"license": "CCBYSA",
"status": "GOLD",
"url": "https://ejurnal.itenas.ac.id/index.php/rekayasahijau/article/download/2041/1802"
}
|
ABSTRAKPembangunan pasar saat ini banyak mengarah ke pengembangan vertikal. Efisiensi dan keterbatasan lahan menjadi pertimbangan untuk membangun pasar secara vertikal. Permasalahan yang sering terjadi adalah tidak berfungsinya lantai (ruang) di lantai atas bangunan sehingga sepi tidak ada aktivitas. Permasalahan yang telah diketahui tersebut hampir terus berulang seiring pembangunan pasar secara vertikal. Tidak adanya pertimbangan budaya berpasar masyarakat Indonesia mungkin menjadi salah satu kegagalan bangunan pasar vertikal. Penelitian ini akan mengkaji desain beberapa pasar vertikal di Bandung yang kurang maksimal dalam pemakaian ruang di lantai atas. Dari hasil kajian penelitian ini diharapkan dapat memberikan gambaran mengenai mengapa area ruang lantai atas pasar vertikal cenderung tidak diminati.Kata kunci: Efisiensi Desain, Ruang Dalam, Pasar VertikalABSTRACTThe current market development leads much to vertical development. Efficiency and limitations of the land into consideration to build the market vertically. The problem that often happens is the malfunction of the floor (space) on the top floor of the building so quiet there is no activity. Known issues are almost constantly recurring as the market develops vertically. The absence of cultural considerations based on Indonesian society may be one of the failures of vertical market buildings. This research will examine the design of some vertical market in Bandung which is less than maximum in the use of space upstairs. From the results of this research study is expected to provide an overview of why the upper floor space area of the vertical market tends not to be in demand.Keywords: Design Efficiency, Space, Vertical Market
|
2022-04-08T00:32:42.758Z
|
250,148,186 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3537972.3538001",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://discovery.ucl.ac.uk/10153283/7/Singh_Exploring%20the%20Design%20Space%20for%20Body%20Transformation%20Wearables%20to%20Support%20Physical%20Activity%20through%20Sensitizing%20and%20Bodystorming_AAM.pdf"
}
|
Negative or disturbed body perceptions are often interwoven with people's physical inactivity. While wearables can support body perception changes (body transformation), the design space of body transformation wearables supporting physical activity remains narrow. To expand this design space, we conducted an embodied co-design workshop with users. Using conceptual and tangible sensitizing tools, we explored/reflected on bodily sensations at three moments of movement execution (before/during/after). Conceptual tools were used to evoke/reflect/capture past lived experiences, while tangible tools were used as ideation probes for sensory bodystorming. Two design concepts emerged, reflecting diverging approaches to body transformation wearables: one focused on reminders and movement correction; the other on sensory augmentation and facilitation. We reflect on how each facilitates useful representations of body sensations during movement, and present methodological recommendations for designing technology for sensory augmentation in this area. Finally, we propose a preliminary prototype based on our design concepts and discuss future steps.
|
2022-08-20T10:00:09.149Z
|
137,665,403 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.396399",
"MAG": "2076168358",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Quasi-isotropic samples of Hexcel T300/914 composite laminate have been impacted in an instrumented drop weight machine. The impact energy ranged from 5 to 8 Joules. Electrical potentials before and after the impact events were monitored using a network of probes mounted on top and bottom surfaces. Impact damage could be readily detected in all samples. A finite element analysis of the potential distribution within a sample, of identical lay-up to the one tested experimentally, has been carried out using the Abaqus 5.8-17 package. Current flow has been observed in each layer of the model. In the model, an artificial impact damage area (size 100x100mm) has been modelled as 13 square delaminations placed on top of each other, between every ply. Changes in the potential field have been found, depending on the location of the damage area. Comparison of calculated and experimentally derived potential measurements give broadly similar responses to creation of impact damage.
|
2022-09-02T13:15:48.256Z
|
94,465,451 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/(SICI)1521-3749(199910)625:10<1740::AID-ZAAC1740>3.0.CO;2-Y",
"MAG": "1970009498",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Die Reaktion von (THF)2Ca[N(SiMe3)2]2 mit Hexacarbonylchrom, -molybdan und -wolfram fuhrt unter Eliminierung von Hexamethyldisiloxan zur Bildung von Tetrakis(tetrahydrofuran-O)calcium-bis[pentacarbonyl(cyano)- chromat(0)] (1), -molybdat(0)] (2) bzw. -wolframat(0)] (3). Wahrend 1 in der zentrosymmetrischen triklinen Raumgruppe P 1 kristallisiert, findet man fur die isotypen Verbindungen 2 und 3 die monokline Raumgruppe P21/n. Bei allen Verbindungen koordiniert das Calciumatom an das Stickstoffatom des Cyano-Liganden, und man beobachtet gewinkelte Ca–N–C-Fragmente mit Werten von 158,3° (1), 161,2° (2) und 161,3° (3).
Tetrakis(tetrahydrofuran-O)calcium bis[pentacarbonyl(cyano)chromate(0)], -molybdate(0)], and -tungstate(0)]
The reaction of (THF)2Ca[N(SiMe3)2]2 with hexacarbonylchromium, -molybdenum, and -tungsten yields hexamethyldisiloxane and tetrakis(tetrahydrofuran-O)calcium bis[pentacarbonyl(cyano)chromate(0)] (1), -molybdate(0)] (2), and -tungstate(0)] (3), respectively. Compound 1 crystallizes in the centrosymmetric space group P 1, whereas the other two complexes 2 and 3 are isotypic (monoclinic, P21/n). In all these compounds the calcium atom is bonded to the nitrogen atoms of the cyano ligands and bent Ca–N–C fragments with angles of 158,3° (1), 161,2° (2), and 161,3° (3) are observed.
|
2022-09-06T02:30:23.143Z
|
162,888,300 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/S0103-21862009000100003",
"MAG": "2143826002",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Nos ultimos anos, a area da teoria da memoria de guerra tem-se desenvolvido enormemente, e a historia oral tem sido uma das suas ferramentas mais poderosas para aceder a memorias pessoais e colectivas. Esta metodologia tem-se revelado fundamental na recuperacao e/ou recolha de experiencias de guerra, violencia e trauma. Para alguns individuos, a guerra encontra-se sempre presente, e uma memoria constante, indelevel, visivel nos seus corpos: quando um ex-combatente se encontra deficientado para toda a vida, tem de viver permanentemente com a guerra, e a sua experiencia passada acaba necessariamente por determinar o seu percurso de vida futuro. Este artigo baseia-se no testemunho do Sr. A. Fortuna, um exemplo vivido desta realidade, um dos cerca de 30.000 ex-combatentes (Ribeiro, 1999) da Guerra Colonial Portuguesa (1961-1974) portadores de deficiencia, entrevistado para um projecto de investigacao de doutoramento sobre as memorias de veteranos deste conflito. Em 1971, o Sr. A. Fortuna, actualmente com 59 anos de idade, perdeu a visao e ambos os bracos na Guine-Bissau, algo que significou posteriormente uma vida inteiramente moldada pela guerra e pela sua deficiencia. A memoria relativa a este conflito - nao obstante o facto de tratar-se de um evento incontornavel da historia portuguesa do seculo XX - continua, em grande medida, inexplorada. Alguns autores salientam que "a vergonha foi tal que, logo em 1974, [...] a Guerra Colonial foi cautelosamente varrida da memoria colectiva" (Ribeiro, 1999), e os seus ex-combatentes encontram-se cobertos por um "sufocante manto de silencio e de abandono" (Gomes, 2004), especialmente os deficientes de guerra, lembrancas incomodas de uma guerra que o pais parece nao ter vontade de recordar. Tomando como ponto de partida a entrevista com o Sr. A. Fortuna, este artigo reflecte acerca de alguns dos desafios que um historiador oral tem de enfrentar quando entrevista veteranos de guerra deficientados. Pretende apresentar um exemplo de como a historia oral pode ajudar a esclarecer um topico menos visivel da historia portuguesa contemporânea.
|
2022-11-18T01:14:13.231Z
|
56,053,564 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1095-8649.1998.TB02017.X",
"MAG": "2166230802",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A total of 1468 young fish representing 66 taxa from the Sinnamary River, French Guiana was classified by complete cluster analysis of mean relative body width and mean relative body height into four groups. These had anguilliform, disciform, flat or intermediate body shapes and belonged chiefly to Gymnotiformes, Perciformes, Siluriformes and Characiformes, respectively. Several of the taxa shifted from one to another body shape during ontogenesis. Seven diet groups were defined by complete cluster analysis. Among these, six groups were represented by carnivorous fish. The three most frequent groups had diets of (1) mainly insect larvae and small crustaceans, (2) insect larvae, and (3) predominantly terrestrial insects. The majority of the fish taxa showed ontogenetic diet shifts. Carnivorous fish usually switched from small-size prey, such as small crustaceans, to intermediate-size prey, such as insect larvae and/or to large-size prey, such as insects and/or fish. However, taxa differed in their capacities to switch from small prey to intermediate and/or to large prey. Taxa of different body shapes had significantly different diets. Disciform fish fed mainly on aquatic insect larvae and terrestrial insects but also, in small amounts, on small curstaceans. Most anguilliform taxa ate insect larvae. Individuals belonging to the depressiform or intermediate morphotype had varied diets ranging from plant debris and substratum to fish.
|
2022-12-14T21:46:29.403Z
|
198,980,852 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fpsyg.2019.01747",
"MAG": "2958637298",
"PubMedCentral": "6684770"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fpsyg.2019.01747/pdf"
}
|
Healthcare professionals including psychotherapists are legally and ethically obliged to ensure informed consent for the provided treatments comprising type and duration or potential benefits and possible risks (e.g., side effects) among others. In the present contribution, we argue that as potential benefit, informed consent can foster the patient’s meaning response. Moerman’s notion of the meaning response as the physiological or psychological effects of meaning in the course and treatment of an illness is a useful concept in explaining the effects of communicating a treatment rationale as part of the informed consent procedure. The more compelling the rational explanation of the targeted treatment effects including an explanatory model and a model of unique and common change mechanisms, the stronger the meaning response is expected to be resulting in increased hope and positive expectations with regard to the treatment.
|
2022-12-16T04:51:10.469Z
|
110,150,233 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/095448299261218",
"MAG": "2159932481",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Reasons are advanced for the apparent lack of use by designers in industry of the design methods provided by Design Science. Suggestions for the alleviation of this situation are also advanced.
|
2022-12-19T04:37:55.682Z
|
25,614,022 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/15548627.2016.1166326",
"MAG": "2346353543",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4922435?pdf=render"
}
|
ABSTRACT A cell needs to maintain a balance between biosynthesis and degradation of cellular components to maintain homeostasis. There are 2 pathways, the proteasome, which degrades short-lived proteins, and the autophagy/lysosomal pathway, which degrades long-lived proteins and organelles. Both of these pathways are also involved in antigen presentation or the effective delivery of peptides to MHC molecules for presentation to T cells. Autophagy (macroautophagy) is a key player in providing substantial sources of citrullinated peptides for loading onto MHC-II molecules to stimulate CD4+ T cell responses. Stressful conditions in the tumor microenvironment induce autophagy in cancer cells as a mechanism to promote their survival. We therefore investigated if citrullinated peptides could stimulate CD4+ T cell responses that would recognize these modifications produced during autophagy within tumor cells. Focusing on the intermediate filament protein VIM (vimentin), we generated citrullinated VIM peptides for immunization experiments in mice. Immunization with these peptides induced CD4+ T cells in response to autophagic tumor targets. Remarkably, a single immunization with modified peptide, up to 14 d after tumor implant, resulted in long-term survival in 60% to 90% of animals with no associated toxicity. These results show how CD4+ cells can mediate potent antitumor responses against modified self-epitopes presented on tumor cells, and they illustrate for the first time how the citrullinated peptides produced during autophagy may offer especially attractive vaccine targets for cancer therapy.
|
2022-12-30T01:19:38.435Z
|
216,770,020 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7742/JKSR.2019.13.7.1015",
"MAG": "3016229885",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the medical field, X-rays are essential in the diagnosis and treatment of diseases, and the use of X-rays continues to increase with the development of imaging technology, but X-rays have the disadvantage of radiation exposure. Although lead protection tools are used in clinical practice to protect against radiation exposure, lead is classified as a heavy metal and can cause harmful reactions such as lead poisoning. Therefore, the purpose of this study is to investigate the usefulness of the shield fabricated using materials of FDM (Fused Deposition Modeling) 3D printer. In order to confirm the filament's line attenuation factor, phantoms were fabricated using PLA, XT-CF20, Wood, Glow and Brass, and CT scan was performed. And the shielding sheet of 100 × 100 × 2 ㎜ size was modeled, the dose and shielding rate was measured by using a diagnostic X-ray generator and irradiation dose meter, and the shielding rate with lead protection tools. As a result of the experiment, the CT number of the brass was measured to be the highest, and the shielding sheet was manufactured by using the brass. As a result of confirming with the diagnostic X-ray generator, the shielding rate was increased in the shielding sheet having a thickness of 6 ㎜ upon X-ray irradiation under the condition of 100 kV and 40 mAs. It measured by 90% or more, and confirmed that the shielding rate is higher than apron 0.25 mmPb. As a result of this study, it was confirmed that the shield fabricated by 3D printing technology showed high shielding rate in the diagnostic X-ray region. there was.
|
2022-01-27T17:17:54.574Z
|
247,943,775 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.37022/wjcmpr.v4i2.208",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://wjcmpr.com/index.php/journal/article/download/208/185"
}
|
As per ICH GCP, monitoring can be defined as “The act of overseeing the progress of a clinical trial, and of ensuring that it is conducted, recorded, and reported in accordance with the protocol, Standard Operating Procedures (SOPs), Good Clinical Practice (GCP), and the applicable regulatory requirement(s).” Clinical experiments are important for deeper understanding of how interventions work in humans. The aim of the monitoring of the clinical trial is to avoid errors that may compromise patient safety and results of the trial and enables more frequent monitoring of the integrity of the trial and could improve safety concerns by detecting errors earlier than expected. Risk-based monitoring in clinical trials is the process of identification, assessment, monitoring and mitigation of risks that could affect the quality or safety of a study. Centralized monitoring has a direct impact on the clinical trials. One of the most basic and fundamental need of centralized monitoring is to avoid the repetition in clinical trials, saving both time and Money. Central monitoring greatly influences the Patient safety, data integrity and monitoring costs in a clinical trial. This helps in increasing the effectiveness of the monitoring process reducing the burden on the sponsor. The basic and fundamental priority of a clinical trial is to ensure the safety and well-being of the subject. In this article, we will be focusing on how Centralized monitoring can increase the effectiveness and efficiency of the monitoring process and source data verification (SDV) in clinical trials with a special emphasis on Risk based monitoring (RBM)
|
2022-04-22T04:36:44.242Z
|
109,198,859 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.429664",
"MAG": "1969646908",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A low-mass sound generator with particularly good performance at low audio frequencies (i.e. 30 to 300 Hz) has been developed. The actuation component is a Thunder actuator (Face Int. Corp.). This actuator is coupled to a resonant compliant diaphragm to increase output in the low frequency band. The modal response of various 28 cm diameter prototypes was monitored using laser Doppler vibrometry and nearfield acoustic holography. The first mode appears near 40 Hz, with a maximum displacement of 3.4 microns per volt. Sound pressure levels measured in the farfield using 200 volts peak drive found nominal levels of 74+/- 6 dB(at 25 cm) over the band from 38 to 330 Hz. Near 45 and 100 Hz the SPL reaches 80 dB. (Above 330 Hz the output is higher, but remains well behaved to at least 2 kHz.) Higher outputs can be obtained by using a higher drive voltage and multiple devices. Because of its low mass, this device is particularly interesting for aerospace applications. This work was developed in the NRL/ONR Smart Blanket program, which is exploring the use of active controlled surface covers for reducing sound levels in payload fairing regions.
|
2022-09-15T12:14:25.531Z
|
25,874,705 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/aas.12234",
"MAG": "1952982671",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cognitive problems early after surgery are often considered transient in nature. Neuropsychological performance and its relation to other recovery parameters have rarely been systematically assessed during this period.
|
2022-10-19T17:28:10.444Z
|
204,512,240 |
{
"externalids": {
"ACL": null,
"ArXiv": "1910.05569",
"DOI": "10.1109/ICIP40778.2020.9191335",
"MAG": "3091296558",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Subspace clustering aims to cluster unlabeled data that lies in a union of low-dimensional linear subspaces. Deep subspace clustering approaches based on auto-encoders have become very popular to learn the linear representation coefficients from data. However, the training of current deep methods converges slowly, which is extremely expensive. We propose a novel Residual Encoder-Decoder network for deep Subspace Clustering (RED-SC) with skip-layer connections to accelerate the convergence, using a new strategy to generate the linear coefficients by learning the linearity of data in multiple latent spaces. Experiments show the superiority of RED-SC in training efficiency and clustering accuracy.
|
2022-10-25T09:47:57.892Z
|
27,829,955 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CCDC.2009.5192490",
"MAG": "2160899435",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Based on the combination of NSGA-II algorithm and parallel genetic algorithm, this paper presents a parallel genetic algorithm for multi-objective optimization (PNSGA). At the evolving process of this new algorithm, an individual migration to improve the parallel searching speed is applied to improve the efficiency of this algorithm and the accuracy of Pareto optimal set; at the same time, an individual update strategy is introduced to keep the diversity of Pareto optimal set. Data show that the Pareto optimal solutions or the solution candidates output by PNSGA that are scattered extensively and uniformly.
|
2022-12-11T07:16:53.472Z
|
10,792,703 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/S-2004-825632",
"MAG": "32440674",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Hemophilia A and B gene therapy requires long-term and stable expression of coagulation factor VIII (FVIII) or factor IX (FIX), respectively, and would need to compare favorably with protein replacement therapy. Onco-retroviral and lentiviral vectors are attractive vectors for gene therapy of hemophilia. These vectors have the potential for long-term expression because they integrate stably in the target cell genome. Whereas onco-retroviral vectors can only transduce dividing cells, lentiviral vectors can transduce a broad variety of cell types irrespective of cell division. Several preclinical and clinical studies have explored the use of onco-retroviral and, more recently, lentiviral vectors for gene therapy of hemophilia A or B. Both ex vivo and in vivo gene therapy approaches have been evaluated, resulting in therapeutic FVIII or FIX levels in preclinical animal models. Whereas in vivo gene therapy using onco-retroviral or lentiviral vectors often led to long-term FVIII or FIX expression from transduced hepatocytes, ex vivo approaches were generally hampered by either low or transient expression of FVIII or FIX levels in vivo and/or inefficient engraftment. Furthermore, immune responses against the transgene product remain a major issue that must be resolved before the full potential of these vectors eventually can be exploited clinically. Nevertheless, the continued progress in vector design combined with a better understanding of vector biology may ultimately yield more effective gene therapy approaches using these integrating vectors.
|
2022-12-17T22:57:24.848Z
|
109,203,935 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.938975",
"MAG": "1995922841",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
When light emitting diodes and semiconductor lasers are being produced, there is often a need of quick measurement of some parameters. Besides current-voltage and current-optical power characteristics we usually measure near field and far field radiation patterns and spectral characteristics. At the Telecommunications Institute of Warsaw University of Technology a number of instruments for quick measurement of these parameters have been designed. A common feature of all these instruments is the usage of TV-camera as an image converter and a TV-monitor to present the results. This permits a quick measurement of important parameters of radiating sources.
|
2022-02-10T06:37:19.570Z
|
159,118,241 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/25765949.2019.1605571",
"MAG": "2942866666",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract This article analyses the US-Turkish relationship in the Middle East. Washington and Ankara’s policies have clashed in Syria, Iran, Israel, Egypt, the GCC states and Iraq. The two NATO members strongly disagree over military sales, the extradition of Fetullah Gulen, the leader of the Hizmet movement accused of fomenting the 2016 coup attempt who is ensconced in Pennsylvania, and their ideological visions often diverge with President Erdoğan’s affinity for the Muslim Brotherhood. Through the use of realist and constructivist theories the article examines the decisions of Presidents Erdoğan, George W. Bush, Barack Obama and Donald Trump as they have impacted US-Turkish relations in the Middle East. The realist lens raises issues of changing systems and questions of balancing, while the constructivist lens is employed to examine the weighty ideational and identity issues prevailing in the region. The article concludes by applying the theoretical analysis to policy solutions.
|
2022-03-11T18:11:17.319Z
|
239,007,661 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/shsconf/202112206005",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.shs-conferences.org/articles/shsconf/pdf/2021/33/shsconf_frph2021_06005.pdf"
}
|
The authors draw attention to the issue of gender differences in the features of the subjective experience of happiness and unhappiness. The article describes the results of a study conducted with clients of psychologists who report problems related to the experience of destructive interpersonal relationships and consider themselves deeply unhappy in life. The purpose of the study is to reveal the gender specificity of the frustration of the subjects’ life needs underlying the deep experience of unhappiness in their lives. A peculiarity of the approach used by the authors is the consideration of issues of psychological nature in the context of philosophical and religious understanding of eternal values, such as happiness and love for one’s neighbor. A special focus of the authors’ attention is the problems related to the philosophical and religious basis of consideration of the feminine as Sophia the Wisdom of God with the complex of her rejection, the dominant sense of guilt, and the desire to return to the Father. Such methodological symbiosis is facilitated by interdisciplinarity as one of the main principles of the authors’ interaction with the materials of this work. The Thematic Apperception Test (TAT) aimed at the amplification of subjects’ unconscious intentions is used as a diagnostic instrument. The conducted psychological study allows to reveal and describe some of the causes for the manifestation and experience of happiness and unhappiness in the lives of modern men and women and show specific differences between their subjective experiences of happiness and unhappiness in their lives. Unlike previous studies of this kind, the deployed philosophical and religious studies approach provides an opportunity to take a new look at the outlined issues considering them from the point of the philosophical context of values.
|
2022-08-20T17:42:42.962Z
|
52,956,998 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3182/20120606-3-NL-3011.00102",
"MAG": "2618220764",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract Pulse-coupled oscillators (PCOs) comprise a class of limit cycle oscillators coupled in an impulsive rather than smooth manner. Their importance in biology and engineering motivated the analysis of the basic properties and design principles of PCO networks. In this work, we address synchronization of non-identical PCO networks with a global cue by using a hybrid systems approach. Using phase response curves as a design element, we characterize solutions and give conditions under which frequency synchronization is achieved. Numerical experiments are provided, which confirm the theoretical findings.
|
2022-11-01T13:43:45.538Z
|
8,469,050 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/jb.105.3.1039-1046.1971",
"MAG": "1811087597",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC248534"
}
|
Kinetic studies of the transport of aromatic amino acids by Pseudomonas aeruginosa revealed the existence of two high-affinity transport systems which recognized the three aromatic amino acids. From competition data and studies on the exchange of preformed aromatic amino acid pools, the first transport system was found to be functional with phenylalanine, tyrosine, and tryptophan (in order of decreasing activity), whereas the second system was active with tryptophan, phenylalanine, and tyrosine. The two systems also transported a number of aromatic amino acid analogues but not other amino acids. Mutants defective in each of the two and in both transport systems were isolated and described. When the amino acids were added at low external concentrations to cells growing logarithmically in glucose minimal medium, the tryptophan pool very quickly became saturated. Under identical conditions, phenylalanine and tyrosine each accumulated in the intracellular pool of P. aeruginosa at a concentration which was 10 times greater than that of tryptophan.
|
2022-11-26T19:39:03.587Z
|
24,467,494 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3324/%X",
"MAG": "2139010634",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND
Little is known about the morphological and clinical features of the minority of acute myeloid leukemias (AML) that carry the t(9;22)(q34;q11) translocation.
MATERIALS AND METHODS
Cytologic, cytogenetic and clinical features were studied at diagnosis and during disease evolution in 11 patients presenting with de novo AML. Diagnoses according to the FAB criteria were AML-M2 (3 cases), AML-MO and AML-M4 (2 cases each), AML-M4eos, AML-M5, AML-M6, AML-M7 (1 case each).
RESULTS
Immunophenotyping disclosed positivity for CD33 or CD13 and for the CD34 stem cell antigen in all cases tested. Lymphoid-associated markers (LM) were detected in 7/9 patients. In 5 cases the expression of at least 2 LM was seen. In addition, evidence of clonal rearrangement of the immunoglobulin (Ig) and/or T-cell receptor (TCR) genes was documented in 3/4 evaluable cases. The Ph chromosome was found as the sole change in 5/11 cases; the karyotype reverted to normal in 2/4 patients who achieved complete remission. Rearrangement in the M-bcr region was detected by Southern blotting in 2/7 cases.
CONCLUSIONS
This infrequent cytogenetic subset of de novo AML appears to be characterized by heterogeneous cytologic features, with frequent expression of lymphoid markers, and by unfavorable prognosis. The combination of clinical, cytologic and cytogenetic studies is important in distinguishing de novo AML with the t(9;22) from chronic myelogenous leukemia blast crisis.
|
2022-12-18T18:09:13.675Z
|
907,583 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fnsys.2011.00054",
"MAG": "2146809119",
"PubMedCentral": "3129135"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fnsys.2011.00054/pdf"
}
|
In the healthy primate, neurons of the external and internal segments of the globus pallidus (GP) present a primarily irregular firing pattern, and a negligible level of synchrony is observed between pairs of neurons. This holds even for neighboring cells, despite their higher probability to receive common inputs and to innervate each other via lateral connectivity. In the Parkinsonian primate, this changes drastically, and many pairs of GP cells show synchronous oscillations. To address the relation between distance and synchrony in the Parkinsonian state, we compared the synchrony of discharge of close pairs of neurons, recorded by the same electrode, with remote pairs, recorded by different ones. However, spike trains of neighboring cells recorded by the same extracellular electrode exhibit the shadowing effect; i.e., lack of detection of spikes that occur within a few milliseconds of each other. Here, we demonstrate that the shadowing artifact can both induce apparent correlations between non-correlated neurons, as well as conceal existing correlations between neighboring ones. We therefore introduced artificial shadowing in the remote pairs, similar to the effect we observed in the close ones. After the artificial shadowing, neighboring cells did not show a higher tendency to oscillate synchronously than remote ones. On the contrary, the average percentage (over all sessions) of artificially shadowed remote pairs exhibiting synchronous oscillations was 35.4% compared to 17.2% in the close ones. Similar trend was found when the unshadowed remote pairs were separated according to the estimated distance between electrode tips: 29.9% of pairs at approximate distance of less than 750 μm were significantly synchronized, in comparison with 28.5% of the pairs whose distance was more than 750 μm. We conclude that the synchronous oscillations in the GP of MPTP treated primates are homogenously distributed.
|
2022-12-19T22:39:20.951Z
|
45,697,312 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1378/CHEST.39.5.477",
"MAG": "2158508013",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
SUMMARY Acute smog disasters have made it clear that air pollution can cause disease and death. The subtle effects of everyday air pollution are, however, less well known, and present a formidable challenge to medical researchers. Statistical correlations based on morbidity and mortality and laboratory studies, constitute the two main directions taken to determine long-term health effects. Neither approach yields results comparable to those which might be expected from long-term, well-controlled, prospective epidemiologic studies from which all variables except the air breathed would be eliminated. A large-scale community health study in Nashville, Tennessee, by the Public Health Service represents the first venture in this field. Morbidity and mortality findings will be correlated with information from an elaborate air sampling network, while other environmental and cultural factors are standardized. But studies much more elaborate than the Nashville study are needed. In the meantime, the need for refined portable pulmonary function instrumentation and for more accurate definition of the disease spectrum under question (asthma—chronic bronchitis—emphysema) are so crucial as to threaten serious delays.
|
2022-02-12T00:21:58.930Z
|
183,120,204 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14399/JACD1999.24.291",
"MAG": "2333717018",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Dentistry has been developed with the benefit of general science, especially medical science and biology, and changed the basic concepts of dental treatment. Endodontology can contribute to comprehensive clinical and basic research areas in which other studies including periodontology, oral surgery, operative dentistry, pedodontics and prosthodontics are also related. However, from the standpoint of evidence-based dentistry, development of Endodontology is not so fruit except root canal preparation and obturation technology. Then we will introduce multidisciplinary study areas and discuss the future direction in which Endodontology will be involved.
|
2022-06-05T00:44:11.166Z
|
154,365,367 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2753/PET1061-1991550901",
"MAG": "2078324492",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The authors analyze the transformation of capitalism in western countries and also the transitional period in Russia.
|
2022-02-09T01:52:36.779Z
|
1,639,006 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/s16060756",
"MAG": "2405408227",
"PubMedCentral": "4934182"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1424-8220/16/6/756/pdf?version=1464177548"
}
|
A novel electrochemical sensor gold nanoparticle (AuNP)/polyvinylpyrrolidone (PVP) modified pencil graphite electrode (PGE) was developed for the ultrasensitive determination of Bisphenol A (BPA). The gold nanoparticles were electrodeposited by constant potential electrolysis and PVP was attached by passive adsorption onto the electrode surface. The electrode surfaces were characterized by electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). The parameters that affected the experimental conditions were researched and optimized. The AuNP/PVP/PGE sensor provided high sensitivity and selectivity for BPA recognition by using square wave adsorptive stripping voltammetry (SWAdSV). Under optimized conditions, the detection limit was found to be 1.0 nM. This new sensor system offered the advantages of simple fabrication which aided the expeditious replication, low cost, fast response, high sensitivity and low background current for BPA. This new sensor system was successfully tested for the detection of the amount of BPA in bottled drinking water with high reliability.
|
2022-12-02T10:25:59.190Z
|
250,363,258 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TIT.2022.3188708",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Information theory-based feature selection (ITFS) methods select a single subset of features for all classes based on the following criteria: 1) minimizing redundancy between the selected features and 2) maximizing classification information of the selected features with the classes. A critical issue with selecting a single subset of features is that they may not represent the feature space in which individual class labels can be separated exclusively. Existing methods fail to provide a way to select the feature space specific to the individual class label. To this end, we propose a novel feature selection method called class-label specific mutual information (CSMI) that selects a specific set of features for each class label. The proposed method maximizes the information shared among the selected features and target class label but minimizes the same with all classes. We also consider the dynamic change of information between selected features and the target class label when a candidate feature is added. Finally, we provide a general framework for the CSMI to make it classifier-independent. We perform experiments on sixteen benchmark data sets using four classifiers and found that the CSMI outperforms five traditional, two state-of-the-art ITFS (multi-class classification), and one multi-label classification methods.
|
2022-11-30T14:15:31.465Z
|
121,098,651 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVA.81.062310",
"MAG": "2034087194",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We study the von Neumann block entropy in the Kondo necklace model for different anisotropies $\ensuremath{\eta}$ in the $\mathit{XY}$ interaction between conduction spins using the density matrix renormalization group method. It was found that the block entropy presents a maximum for each $\ensuremath{\eta}$ considered, and, comparing it with the results of the quantum criticality of the model based on the behavior of the energy gap, we observe that the maximum block entropy occurs at the quantum critical point between an antiferromagnetic and a Kondo singlet state, so this measure of entanglement is useful for giving information about where a quantum phase transition occurs in this model. We observe that the block entropy also presents a maximum at the quantum critical points that are obtained when an anisotropy $\ensuremath{\Delta}$ is included in the Kondo exchange between localized and conduction spins; when $\ensuremath{\Delta}$ diminishes for a fixed value of $\ensuremath{\eta}$, the critical point increases, favoring the antiferromagnetic phase.
|
2022-12-13T14:22:08.562Z
|
354,048 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/mds.22209",
"MAG": "2077231496",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The objective of this work is to determine risk factors for falling in patients with Parkinson's disease (PD) using home‐based assessments and develop a prediction model. Data on falls, balance, gait‐related activities, and nonmotor symptoms were obtained from 153 PD patients (Hoehn‐Yahr 2–4) in their home. Fifty‐one candidate determinants for falling were independently tested using bivariate logistic regression analysis. A multivariate logistic regression model was developed to identify patients susceptible to falls. Sixty‐six subjects (43%) were classified as fallers. Eighteen determinants for falling were selected. The final multivariate model showed an accuracy of 74% and included: (1) Freezing of Gait Questionnaire, (2) Timed Get Up and Go (TGUG) score, (3) disease duration, (4) item 15 of the Unified Parkinson's Disease Rating Scale. Based on disease duration, freezing symptoms, walking problems, and a prolonged TGUG duration, assessed in the home situation, it was possible to accurately identify 74% of PD patients as fallers. © 2008 Movement Disorder Society
|
2022-12-12T20:24:12.184Z
|
122,328,420 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2140/PJM.1978.78.139",
"MAG": "2032493295",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
It is a result of the author and Jose M. Montesinos ([2], [5]) that every closed orientable 3-manifold is a three fold dihedral covering of S branched over a knot or link. Indeed, this can be done in a wide variety of ways satisfying various side conditions ([3]). This result, together with the above theorem can be viewed as saying that every closed orientable 3-manifold and certain closed orientable 4-manifolds are topologically like Riemann surfaces. Indeed, given such an M there is an S multivalued function / (see §4) defined on S 3 o r 4 such that M* is the graph of /. Moreover, locally the singularities of / look like (x, z)-+λ/ z or (xlf x2, z) —> V T . It is unknown which closed orientable 4-manifolds can be 3-fold dihedral covering spaces of S branched over orientable surfaces. But Montesinos ([7]) has recently shown that a large and important class of four manifolds with boundary are three fold dihedral coverings of D\ branched over locally flat, but not necessarily orientable, properly embedded surfaces. On the other hand, it is a result of Edmonds and Berstein that S x S x S x S and many other closed orientable four manifolds cannot be threefold branched covering
|
2022-12-15T04:25:53.427Z
|
85,497,434 |
{
"externalids": {
"ACL": null,
"ArXiv": "1809.08046",
"DOI": "10.1137/18M1215980",
"MAG": "2889673235",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this paper we develop a framework for parameter estimation in macroscopic pedestrian models using individual trajectories -- microscopic data. We consider a unidirectional flow of pedestrians in a corridor and assume that the velocity decreases with the average density according to the fundamental diagram. Our model is formed from a coupling between a density dependent stochastic differential equation and a nonlinear partial differential equation for the density, and is hence of McKean--Vlasov type. We discuss identifiability of the parameters appearing in the fundamental diagram from trajectories of individuals, and we introduce optimization and Bayesian methods to perform the identification. We analyze the performance of the developed methodologies in various situations, such as for different in- and outflow conditions, for varying numbers of individual trajectories and for differing channel geometries.
|
2022-12-20T22:04:38.336Z
|
125,021,717 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2514/6.2013-1647",
"MAG": "2333381875",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Stringent weight and size constraints on flapping-wing micro-air-vehicles dictate minimal actuation. Unfortunately, hovering and forward flight require different wing motions and, as such, independent actuators. Therefore, a hovering or a forward-flight requirement should be included in the mission and design statements of a flapping-wing micro-airvehicle. This work proposes a design for an actuation mechanism that would provide the required kinematics in each flight condition using only one actuator. The idea is to exploit the nonlinear dynamics of the flapping wing to induce the saturation phenomenon. One physical spring in the plunging direction is needed along with a feedback by the plunging angle into the control torque of the actuator in the back and forth flapping direction. By detuning the feedback gains away from the saturation requirement, flapping kinematics required for hovering are obtained. In contrast, by tuning the feedback gains to induce the saturation phenomenon, the motion is transferred into the plunging direction. Moreover, the actuating torque (in the flapping direction) would then provide a direct control over the amplitude of the plunging motion, while the amplitude of the actuated flapping motion saturates and does not change as the amplitude of the actuating torque increases.
|
2022-09-06T07:24:32.312Z
|
90,724,059 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1654/1525-2647-84.2.155",
"MAG": "2746385424",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT: Caecincola septimus n. sp. is described from the intestine of largemouth bass (Micropterus salmoides) collected from Turkey Creek and Menard Creek in the Big Thicket National Preserve, Texas, U.S.A. Members of the new species are most easily distinguished from Caecincola longiscens and Caecincola cookorum by having ceca that do not extend past the anterior testis or into the posttesticular space, and from the remaining species in the genus (Caecincola autumnae, Caecincola latostoma, Caecincola parvulus, and Caecincola wakullata) by a combination of body size and shape, arrangement of the testes, number of ovarian lobes, and size of the oral sucker. This is the fourth species of Caecincola described from largemouth bass, the others being C. parvulus from Wisconsin, C. wakullata from Florida, and C. latostoma from Louisiana.
|
2022-02-10T18:42:36.261Z
|
234,127,801 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/23311975.2020.1870798",
"MAG": "3120177262",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/23311975.2020.1870798?needAccess=true"
}
|
Abstract There are rare studies that have attempted to explore the association among green human resource management (GHRM) and organizational commitment in the existing literature. Besides, the mediating role of green human capital has also garnered little attention in the literature. Hence, the present study intends to address the research gap by extending the ability-motivation-opportunity theory (AMO) to determine the indirect and direct impact of GHRM in the dairy companies which has so far neglected in Pakistan. A convenience sampling technique was deployed to obtain data from 287 respondents through self-administered survey. SmartPLS (3.2.9) software was used to analyze the structural and measurement model. The results demonstrate the direct effect of green recruitment and selection and green training and development on organizational commitment. Also, green human capital contributes an essential role in mediating the effects of green recruitment and selection, green training, and development on organization commitment. The present study suggests that GHRM practices play a crucial role in the deployment of an environmental policy aimed at promoting green practices in the workplace. The findings provide guidelines to policymakers and managers regarding GHRM to promote environmental culture and employee green behavior at the workplace.
|
2022-12-26T06:04:29.329Z
|
208,742,254 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/000992287901800601",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In his editorial for the first issue of Clinical Pediatrics, Irving J. Wolman, M.D. wrote "Clinical Pediatrics, here presented in its first issue, aims to bring to its readers, with promptness, accuracy and efficiency, knowledge concerning the care of infants and children." A contributor to that first issue with an article on bacterial upper respiratory infection in children, today takes on this challenge as Editor-in-Chief of Clinical Pediatrics. We take great pleasure in introducing the new Editor-in-Chief, David Cornfeld, M.D. A native of Philadelphia and a graduate of the University of Pennsylvania School of Medicine, Dr. Cornfeld comes to the journal with a distinguished career in pediatric medicine. He is presently Professor and Associate Chairman of the Department of Pediatrics at the University of Pennsylvania School of Medicine. He is certified by the American Board of Pediatrics and the American Board of Pediatric Nephrology and is a Fellow in the College of Physicians of Philadelphia and the American Academy of Pediatrics. His many other accomplishments, too numerous to mention here, all testify to his dedication to the practice of medicine and more particularly pediatric medicine. We at the publishing offices know Dr. Cornfeld as an editor who has brought with him a sense of vitality that we know will reflect in the journal. We know him, too, as an editor with whom we will work to publish a journal which we will be proud of. As did Janus, we look backward and forward at the same time. Backward to many productive years under the stewardship of Irving Wolman and forward to many more productive years being guided by David Cornfeld. To Dr. Cornfeld, we say we are happy you have joined us. The Publisher
|
2022-01-27T19:54:11.976Z
|
56,220,252 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14228/JPR.V1I5.102",
"MAG": "1482824144",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Background : Adult primary palatoplasty is more challenging tha n in infants because the gaps are wider. The risk ofintraoperative bleeding and palatal fistula are higher. Most adults with un-operated palatal cleft have good maxillary growth but poor speech. The aim of this study is to introduce our technique in repairing wide cleft palate in adult patients. Patients and Methods : We report four patients with cleft palate who underwent palatoplasty at adulthood. The age ranges from 17 to 20 years. Interspina distance were between 2 to 3.5 cm. All of them were nonsyndromic and had normal maxillary growth. The surgical technique used on these patients was two-flap palatoplasty with an additional 3 mm gingival bulk on the lateral side of the flap. Honey was given as oral drops postoperatively. Result : Lateral palatal defect healed well and epithelialized completely between 7 -14 days postoperative and only one small palatal fistula was found with this modified technique. All subjects had good maxillary growth, and speech outcome was poor to begin with. Summary : Two-flap palatoplasty can adequately provide palatal closure, especially with an additional lateral flap extension to include gingival components. This extension widens the flaps and aid palatal closure by not leaving lateral defects too wide.
|
2022-07-07T04:36:44.525Z
|
55,528,834 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.22323/1.301.1032",
"MAG": "2804924478",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://pos.sissa.it/301/1032/pdf"
}
|
The Baikal-GVD is a cubic kilometer scale neutrino telescope which is deployed in Lake Baikal,
that will perform neutrino astronomy studies. It consists of sub-arrays - clusters of about 300
optical modules each, that detect the Cherenkov light radiated by charged particles induced by
neutrino interactions with the surrounding medium. The performance of the neutrino telescope
relies on the precise timing and positioning calibration of the detector elements, continuous
control and monitoring of a behavior of measuring systems, as well as environmental conditions
which may affect light detection and event selection. This contribution describes the units which
are used in GVD for calibration and monitoring purposes.
|
2022-02-11T19:48:11.483Z
|
84,206,949 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4319/LO.1981.26.4.0697",
"MAG": "2008512462",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
During 1977, the population density of Hydra in the rocky littoral community in Toolik Lake, Alaska, increased from June to a maximum in late July or early August, then remained stable or decreased slightly through late August. The summer increase of Hydra corresponded to increases in the availability of copepods and Bosmina (the preferred prey) until late July. Hydra kept at lake temperatures in the laboratory with unlimited prey reproduced fast enough asexually to account for these increases: at 19°C the intrinsic rate of increase (r, biomass) was 0.53 g·g‒1·d‒1, and at 11°C, r = 0.31·d‒1. These rates, much higher than those for other Hydra at comparable temperatures, seem to be a metabolic adaptation to arctic conditions. Failure of the Hydra population to continue to increase while food resources increased in August is attributed to predation by Lymnaea, displacement by epilithic algal growth, endogenously controlled emigration from the rocky littoral, or some combination of these.
Hydra appears to be the most important predator on Bosmina. Hydra at densities of 135·m‒2 on the rocky shoals could take 1,620 Bosmina · m‒2·d−1 during late July and early August 1977, about 10% per day consumption of the estimated lake standing crop of Bosmina. This is the first evidence that Hydra plays a major role in controlling a prey population.
|
2022-11-18T19:23:47.343Z
|
213,566,824 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/09614524.2020.1715344",
"MAG": "3004810109",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Idiosyncratic shocks are among the major shocks affecting smallholder households. Social networks have been widely used by households as an informal strategy to smooth consumption. This article uses panel data from 719 smallholder farmers in Kenya and a fixed effects panel data regression model to evaluate the effect of social networks on food consumption smoothing in the presence of health shocks. Fixed effects estimates show that financial credit networks have a positive and significant effect on insurance of purchased food consumption against health shocks, indicating that the networks play an insurance role against health shocks.
|
2022-12-07T05:59:07.976Z
|
55,666,373 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/BIOCONF/20150400006",
"MAG": "1507854672",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Hexapoda is the most diverse clade of the history of life. They cannot be considered as the oldest terrestrial animals and the first Hexapoda were small apterous animals of the Devonian soil fauna, apparently not very diverse and “dominated” by myriapods and arachnids at that time. Things dramatically changed during the Early Carboniferous with the appearance and the expansion of the winged insects. This crucial innovation allowed this clade to diversify in a spectacular way in the Late Carboniferous. The main clades were already present at the end of this period, viz. Palaeoptera, “Polyneoptera”, Paraneoptera and Holometabola. The latter two groups became truly diverse and began to dominate the animal kingdom after the major Permo-Triassic biodiversity crisis. Nevertheless a causal link is difficult to establish between the two phenomena. After the Triassic, all insect orders are present and many modern families are as old as the Jurassic, a situation completely different from that of the terrestrial vertebrates. The last major change in the hexapods took place about 100 Ma ago, and may be linked with the mid-Cretaceous angiosperm diversification, but apparently not with the supposed major crisis of diversity at the end of the Cretaceous.
|
2022-12-20T13:26:10.368Z
|
234,902,000 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.36550/2415-7988-2020-63-191",
"MAG": "3133232438",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The study provides a detailed analysis of recent research and publications on the notion of readiness for professionally oriented foreign language communication and its components, which allowed to establish links with the concept of readiness of future bachelors of law for professionally oriented foreign language communication. At the moment the problem of forming this quality at law schools in Ukraine is rather urgent as their students lack a good command in English which is proved by the results of the single entrance exam in foreign languages for applicant intending to do a master's course, as they are quite disappointing. Thus, it requires a review of approaches to forming the readiness of future bachelors of law for professionally oriented foreign language communication.
Through the prism of the peculiarities of the legal profession, the author distinguished the immanent features of this concept such as multilevel, i.e. the presence of a certain structure, built due to the influence of mental processes, personality traits, and showing of foreign language competence, which can be transformed due to proper training and manifested in the future activities of legal professional due to presence of a set of knowledge, skills and abilities to use legal language in the process of professional communication. This allowed to determine the structure of the analyzed category, which contains motivational, cognitive, activity and reflection components. The motivational component includes a combination of such legal students’ qualities as interest in learning a foreign language for professional purposes, as well as relevant needs, motives, values, indicating the desire to constantly develop foreign language competence and ability to communicate in it. The cognitive element of the studied readiness presupposes the presence of linguistic and professional knowledge, an idea of the essence of foreign language communication in the legal sphere, the ability to project the results of one’s studies for future activities. The activity component is interpreted as a set of practical skills and abilities application of which acts as a prerequisite of successful communication on professional topics. The presence of a reflective component presupposes students’ ability to reflection, adequate self-esteem, control of their own foreign language communicative activities and objective assessment of interlocutors’ communicative behaviour.
|
2022-01-27T10:37:39.937Z
|
185,673,471 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15761/SRJ.1000102",
"MAG": "2605076891",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Received: February 28, 2017; Accepted: March 13, 2017; Published: March 15, 2017 Education is an important part of the practice of medicine. The Hippocratic oath comments on education in medicine stating “teach them this art, if they shall wish to learn it, without fee or contract; and that by the set rules, lectures, and every other mode of instruction” [1]. One of the skills that every anesthesia resident must become an expert in prior to graduation is fiberoptic intubation. Fiberoptic intubation is key for safely securing the difficult airway. If this skill set lacking harm to patients will certainly occur. A problem with teaching a lifesaving skill in situations where a skilled practitioner is needed to prevent patient harm is that an unskilled novice may cause harm to the patient while they are learning. This is one reason that simulation is often used to teach fiberoptic intubations (Figures 1, 2 and 3).
|
2022-02-08T11:23:48.495Z
|
204,355,330 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.24320/redie.2019.21.e28.2116",
"MAG": "2976348716",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://redie.uabc.mx/index.php/redie/article/download/2116/1795"
}
|
El objetivo de este artículo es analizar, por un lado, los resultados de las pruebas de Ciencias Sociales del examen de Estado del año 2016 en Colombia y, por el otro, las opiniones de los estudiantes sobre la preparación que reciben para dicha prueba en el marco de los procesos de evaluación de la asignatura. Se utilizó una metodología cuantitativa con información de dos fuentes: el Instituto Colombiano para la Evaluación de la Educación y una encuesta. Los datos se sistematizaron utilizando el programa estadístico Infostad Profesional. Se determinó que, si bien estas pruebas describen el logro de niveles particulares de desempeño de los estudiantes en el área de Ciencias Sociales, es necesario que estos resultados puedan ayudar a comprender aspectos curriculares y prácticas de enseñanza; esto implica un desplazamiento en la pregunta “cuánto saben los estudiantes” a “qué saben” y “qué son capaces de hacer”, y centrar la reflexión en los usos pedagógicos de los resultados de los exámenes.
|
2022-04-01T01:45:26.881Z
|
210,288,200 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1742-6596/1299/1/012052",
"MAG": "2979942058",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/1299/1/012052"
}
|
The effects of some essential meteorological variables such as temperature, relative humidity and mean sea level pressure on the Ultra High Frequency (UHF) radio signals from Edo Broadcasting Service (EBS) transmitting at 743.25 MHz UHF and Very High Frequency (VHF) radio signals from Nigerian Television Authority (NTA) transmitting at 189.25 MHz VHF both in in Benin City, Edo State, South-South region of Nigerialocated within 6°20’17″N and 5°37’32″E was evaluated in this study. The measurements of the radio signal strength from EBS television station and radio signal strength from NTA television station were done using the Digital Community-Access/Cable Television (CATV) analyser, while a self-implemented weather monitoring device was used for the measurement of the weather variables simultaneously at an equidistant position within the City. The measurements were carried out continuously for every six hours (between 12am-1am, 6am-7am, 12pm-1pm and 6pm-7pm local time respectively) all through the year, 2018. From the obtained results, it was observed that the radio signals from both the UHF and VHF television stations were directly proportional to the temperature, inversely proportional to the relative humidity and no defined pattern of proportionality with the mean sea level pressure. Inferentially, the radio signals from the UHF television station were seen to be mostly affected by these weather variables and these effects were more pronounced during the months with high relative humidity compared with the months with lower relative humidity. However, a postulation that would still be subjected to further verification has been proposed from these results. It is believed that these results and proposed postulation would definitely be helpful in guiding and assisting the management of radio communication systems for planning and other purposes.
|
2022-10-13T15:39:11.842Z
|
111,054,008 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.266708",
"MAG": "2078593693",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this work the application of a-Si:H thin film transistor technology in the field of chemical sensors is presented. In particularly, the optimization of magnetron deposition process for obtaining various silicon nitride films and TFT structures are described as well as adequate structures of Ion Sensitive Field Effect Transistor with respect to the ion sensitive hydrogen properties are studied. The device shows a good Nernst response and high reproducibility but not acceptable stability yet.
|
2022-02-10T04:36:50.647Z
|
20,820,970 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICECENG.2011.6056778",
"MAG": "2163464420",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In order to enhance the learners' key competence in the elementary school, this study integrate 5E learning cycle and ICT-based PBL into nature science learning. The research adopts quasi-experiment design, and conducts a nature science learning experiment of the third grade students. The experiment group accept ICT-based PBL model and utilize Intel thinking tool and eXe software to discuss, organize and record their process and works. On the other hand, the learners of control group accept the traditional PBL model. The experiment lasts for one semester. The meta-cognition inventory and technology-oriented creative inventory are employed to survey the difference between those two groups. The results indicate that the experiment group perform better in most of technology-oriented creative inventory than the control group, but creative abilities of those two groups was promoted on the same time under the traditional or ICT-based PBL model. Nevertheless, merely self-test facet of meta-cognition is enhanced significantly on the experiment group.
|
2022-02-12T21:46:44.874Z
|
42,503,321 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1600-0536.2010.01805.x",
"MAG": "2150768907",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Three methacrylate allergens, methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (2-HEMA), and ethyleneglycol dimethacrylate (EGDMA), were purchased from Chemotechnique Diagnostics (Vellinge, Sweden). These were compounded in 2.0% wt/wt petrolatum (pet.) and inserted into capped polypropylene syringes (with and without aluminium foil wrapping) and IQ chambers (Chemotechnique Diagnostics) without aluminium foil. Approximately 4 ml of each preparation was inserted into a syringe and approximately 30 mg of preparation into each polyethylene IQ chamber. The tape with the chambers was protected by the manufacturer’s stiff plastic cover with 10 compartments that correspond to the chambers on the tape. The syringes were sent in triplicate for each allergen with and without aluminium foil wrapping, and two unwrapped samples in IQ chambers for each methacrylate were sent. These were then packaged in an airtight plastic bag and sent via normal airmail to the National Skin Centre, Singapore. Upon receipt of the packaging, the allergens were then sent back to the Malmö department immediately, without being opened in Singapore. The estimated travelling time was approximately 28 hr by air and at least 4 hr on land. Upon arrival back at our laboratory, the allergens in the syringes and IQ chambers were analysed by highperformance liquid chromatography (to be published) for actual methacrylate allergen content. The detection limit for the allergens in the system that we used was 0.00011%. The results are shown in Table 1. After allowing for the allergen loss due to our compounding process, we found that the patch test preparations sent in capped syringes retained their original allergen concentration whether or not they had been wrapped in aluminium foil, whereas those in IQ chambers with lids but without aluminium foil wrapping had lost almost their entire allergen content, for MMA and 2-HEMA in particular.
|
2022-09-11T06:40:00.142Z
|
80,476,659 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.29080/jhsp.v1i2.78",
"MAG": "2769539105",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "http://jurnalfpk.uinsby.ac.id/index.php/jhsp/article/download/78/80"
}
|
Infant massage is a traditional child care whose efficacy has been proven. Therefore, the mothers need to get a health extension on the correct infant massage techniques so that they can do infant massage practice autonomously. This research aim to investigate the effect of infant massage extension on the infant massage practice by mothers in Tugu village, Jumantono sub-district, Karanganyar regency. The research used pre-experimental research method with the one group pretest-posttest design. Its samples consisted of 57 respondents and were taken by using proportional random sampling technique. The data of research were collected through checklist and analyzed by using the Wilcoxon test aided with the computer program of SPSS. Prior to the infant massage extension, the average score was 10.8, the highest score was 14, and the lowest score was 8. Following the extension, the average score was 25.6, the highest score was 29, and the lowest score was 21 as indicated by the score of Wilcoxon test in which the score of ZÂ was -6.583 and the significance value was p = 0.000. Infant massage extension had an effect on the infant massage practice by mothers.
|
2022-11-08T17:37:50.438Z
|
139,000,532 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/SSP.134.87",
"MAG": "2229513457",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
According to the ITRS Roadmap [1], new dielectric and metal gate materials will be required for high performance and low stand-by power applications at the 45 nm technology node and beyond. Currently, many candidate materials are under investigation. Based on the state-of-the-art [2,3,4], some of the most likely candidates to be used as metal gate electrodes include TiN, TaN, Mo and Ru. To address the workfunction tuning issue in this future generation of transistors, a possible approach is to use a metal layer on the high-k dielectric to control the workfunction and a conductor material on top to make the gate electrical contact (fig. 1). As a result, it creates a risk of galvanic enhanced corrosion at the gate electrode level during wet cleaning. We have studied galvanic coupling between the dissimilar materials of the gate electrode (TiN, Mo, Ru, PolySilicon). The study focuses on diluted HF mixtures, which in general show overall better compatibility with metal gates than strong oxidizing chemistries. Diluted HF based mixtures are used for residual high-k removal and post-etch residues removal [5]. In addition, it is also used for removal of oxide hardmask after etching of the metal gate stack.
|
2022-12-10T17:47:15.420Z
|
250,205,700 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fpls.2022.902068",
"MAG": null,
"PubMedCentral": "9280032"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fpls.2022.902068/pdf"
}
|
Cysteine S-nitrosation is a redox-based post-translational modification that mediates nitric oxide (NO) regulation of various aspects of plant growth, development and stress responses. Despite its importance, studies exploring protein signaling pathways that are regulated by S-nitrosation during somatic embryogenesis have not been performed. In the present study, endogenous cysteine S-nitrosation site and S-nitrosated proteins were identified by iodo-TMT labeling during somatic embryogenesis in Brazilian pine, an endangered native conifer of South America. In addition, endogenous –S-nitrosothiol (SNO) levels and S-nitrosoglutathione reductase (GSNOR) activity were determined in cell lines with contrasting embryogenic potential. Overall, we identified an array of proteins associated with a large variety of biological processes and molecular functions with some of them already described as important for somatic embryogenesis (Class IV chitinase, pyruvate dehydrogenase E1 and dehydroascorbate reductase). In total, our S-nitrosoproteome analyses identified 18 endogenously S-nitrosated proteins and 50 in vitro S-nitrosated proteins (after GSNO treatment) during cell culture proliferation and embryo development. Furthermore, SNO levels and GSNOR activity were increased during embryo formation. These findings expand our understanding of the Brazilian pine proteome and shed novel insights into the potential use of pharmacological manipulation of NO levels by using NO inhibitors and donors during somatic embryogenesis.
|
2022-12-16T13:17:03.600Z
|
32,981,517 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1006/anbe.1999.1240",
"MAG": "2160732085",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
The effects of parasites on host fitness and the fitness effects of maternal effects are widely discussed. In this study, I conducted an experiment linking both aspects. I manipulated the ectoparasite load (Acari: Arrenurus cuspidator) of damselflies, Coenagrion puella, and found that larvae from mothers with high parasite loads were larger (assessed by head width) than larvae from mothers with low parasite loads. Furthermore, there was a negative correlation between the number of eggs laid and parasite load. Parasitized mothers thus seemed to have fewer, but probably better, offspring. The ecological significance of these parasite-mediated maternal effects remains to be tested. However, size-dependent cannibalism almost certainly has important consequences for population dynamics. Copyright 1999 The Association for the Study of Animal Behaviour.
|
2022-12-17T09:13:45.484Z
|