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205,834,527 |
{
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"DOI": "10.1080/14779072.2018.1449646",
"MAG": "2791465972",
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|
ABSTRACT Introduction: Compared with the left ventricle (LV), the right ventricle (RV) is less suited for evaluation by echocardiography (ECHO). Nevertheless, RV ECHO-assessment has currently emerged as an important diagnostic tool with meaningful prognostic value and essential contribution to therapeutic decisions. Although significant progress has been made, including generation of higher-quality normative data, validation of several two-dimensional measurements and improvements in three-dimensional ECHO-techniques, many challenges in RV ECHO-assessment still persist. Areas covered: This review discusses the particular challenges and limits in obtaining accurate measurements of RV anatomical and functional parameters and focuses primarily on the difficulties in proper interpretation of the highly load dependent RV ECHO-parameters which complicates the use of this valuable diagnostic and surveillance technique. Expert commentary: There is increasing evidence that RV assessment in relation with its actual loading conditions by ECHO-derived composite variables, which either incorporate a certain functional parameter and load, or incorporate measures which reflect the relationship between RV dilation and RV load, considering also the right atrial pressure (i.e. ‘load adaptation index’), is particularly suited for clinical decision-making. Load dependency of RV ECHO-parameters must be taken into consideration especially in patients with advanced RV dysfunction scheduled for LV assist device implantation or lung transplantation.
|
2022-11-12T03:17:25.477Z
|
95,718,337 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.938866",
"MAG": "2032796717",
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},
"license": null,
"status": null,
"url": null
}
|
The interaction of light with a-cyclodextrin-iodine inclusion compounds was studied with aim of obtaining optically bistable elements. A simple model, developed to explain the dichroic properties of these compounds, predicts important photodichroism. This is reported along with preliminary experiments. Finally, other means of inducing dichroism are surveyed.
|
2022-02-10T15:19:41.513Z
|
239,593,895 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31219/osf.io/pzg2m",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://osf.io/pzg2m/download"
}
|
Masa nifas merupakan hal penting untuk diperhatikan guna menurunkan angka kematian ibu dan bayi di Indonesia. Asuhan masa nifas penting diberikan pada ibu dan bayi, karena Merupakan masa krisis baik ibu dan bayi.
|
2022-07-10T22:24:51.543Z
|
92,632,012 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1101/561340",
"MAG": "2917288856",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GREEN",
"url": "http://www.cell.com/article/S2211124719309106/pdf"
}
|
Consistent daylight oscillations and abundant oxygen availability are fundamental to human health. While both are connected from an evolutionary and cellular perspective, only oxygen is an established therapy in cardiovascular medicine. Here, we probe the mechanistic intersection between light-(Period 2, PER2) and oxygen-(hypoxia inducible factor, HIF1A) sensing pathways in cellular adaptation to low oxygen conditions with respect to myocardial ischemia.Using a whole genome array from daylight exposed wildtype orPer2−/−mice, an affinity purification-mass spectrometry-based proteomics screen for PER2 targets in hypoxic human endothelial cells, and targeted metabolomics from human healthy volunteers after daylight therapy, we investigated the intersection of light and hypoxia elicited pathways. Housing mice under daylight conditions prior to myocardial ischemia and reperfusion (IR)-injury, uncovered circadian PER2 amplitude enhancement as novel cardioprotective strategy, mimicking HIF1A metabolic adaptation to myocardial ischemia in a PER2 regulated manner. Whole genome array analysis from daylight exposed wildtype andPer2−/−mice or myocardial IR-injury in endothelial specific PER2 deficient mice (Per2loxP/loxP-VE-Cadherin -Cre) revealed a critical role for light elicited PER2 in maintaining the endothelial barrier function during myocardial ischemia. Mechanistic studies in human endothelia pointed towards a master transcriptional regulatory role for endothelial PER2 in metabolic reprograming to hypoxia via HIF1A, which was mimicked during normoxic PER2 stabilization. Translational investigation of light elicited pathways in human healthy volunteers found similar increases of PER2 or mimicking of HIF1A dependent metabolism. These studies identify light elicited circadian amplitude enhancement of endothelial PER2 as a novel cardioprotective strategy. Furthermore, these studies identify PER2 as critical control point of endothelial metabolic reprograming to maintain vascular integrity during myocardial IR-injury and implicate the use of daylight therapy to increase endothelial PER2 signaling as a strategy for the treatment of coronary artery disease.
|
2022-12-14T01:02:20.523Z
|
248,307,057 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3346/jkms.2022.37.e131",
"MAG": null,
"PubMedCentral": "9039195"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.3346/jkms.2022.37.e131"
}
|
Myocarditis and/or pericarditis have been reported as adverse events following coronavirus disease 2019 (COVID-19) messenger RNA vaccination, with most cases occurring within 1 week after the second dose. We report a rare case of myocarditis after the first dose of the BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine in a 17-year-old boy. Here, we describe the laboratory, electrocardiographic, and imaging findings of myocarditis.
|
2022-12-13T01:47:05.310Z
|
5,690,326 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/1.JEI.25.2.023013",
"MAG": "2332589008",
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"status": null,
"url": null
}
|
Abstract. We establish a practical regularized least-squares model with adaptive regularization for dealing with blur and mixed noise in images. This model has some advantages, such as good adaptability for edge restoration and noise suppression due to the application of a priori spatial information obtained from a polluted image. We further focus on finding an important feature of image restoration using an adaptive restoration model with different regularization parameters in polluted images. A more important observation is that the gradient of an image varies regularly from one regularization parameter to another under certain conditions. Then, a modified graduated nonconvexity approach combined with a median filter version of a spatial information indicator is proposed to seek the solution of our adaptive image-restoration model by applying variable splitting and weighted penalty techniques. Numerical experiments show that the method is robust and effective for dealing with various blur and mixed noise levels in images.
|
2022-08-20T19:19:42.178Z
|
174,813,925 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1542/peds.2018-2857",
"MAG": "2948165343",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Although all 50 states permit children with asthma to self-carry personal inhalers, access to emergency inhalers may be as low as 14%.1 Every child could have access when needed if albuterol were allowed to be stocked at schools.1 This problem affects all children: rich or poor, private-schooled or public-schooled, urban or rural. There are many reasons why a child might not have an inhaler at school: they forgot it, they could not afford it, they unexpectedly ran out, or it might have expired. When children do not have albuterol, schools have few options. A parent may not be immediately accessible or able to respond promptly. Even if they can, the attack often worsens with delays. Generally, the school must call 911. This may lead to an ambulance transport and an emergency department visit; furthermore, such events take children out of the classroom and impede their learning. In a study of asthma-related deaths in the school setting between 1990 and 2003, authors cited 38 reported asthma school deaths, which the authors believe was an underestimate.2 Thirty-one percent of these children died while waiting for medical intervention.2 These adverse events are likely avoidable with stock inhalers because access to rescue medications is a key component of guideline-based response in asthma emergencies.3,4 Schools can …
Address correspondence to Andrea A. Pappalardo, MD, Department of Pediatrics, University of Illinois at Chicago, 840 S Wood St, M/C 856, Chicago, IL 60612. E-mail: apappa2{at}uic.edu
|
2022-09-23T00:49:37.543Z
|
145,663,553 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0094582X9702400604",
"MAG": "2128998365",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In December 1993, serious riots erupted in Santiago del Estero and La Rioja, Argentina, when thousands of public workers protested against economic adjustment measures and government corruption. The workers had not been paid since the previous July and had just learned that provincial government officials had granted themselves a generous raise. In Santiago, government buildings and officials' homes were burned, and workers battled police and troops of the Gendarmeria (a militarized security force) in the streets. At least four people died and dozens were hurt. In March 1994, as the impact of President Carlos Menem's neoliberal economic policies spread throughout the country, other uprisings occurred in Jujuy, one of the poorest provinces, when public workers demanding a living wage clashed with riot police armed with rubber bullets and a harsh form of vomit gas, and in Tucumain, when demonstrating sugar workers took over the legislature. In July 1994, opposition unions convoked a federal march against the economic model that brought tens of thousands of the poor and workers to the capital in the largest rally in years. Some 43,000 police monitored the march with water cannons and riot gear; helicopters armed with sophisticated video surveillance cameras were also used. Strikes and protests escalated in 1995, bringing the provinces into a state of virtual social rebellion; in Tierra del Fuego a worker died in battles with riot police. In 1996 Menemist unions joined opposition unions for the first time in sharp criticisms of and protests
|
2022-09-24T16:46:12.934Z
|
125,732,753 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1070/QEL16853",
"MAG": "2903971924",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The generation of strongly chirped dissipative solitons offers great opportunities for generating high-power laser pulses of short duration. We demonstrate the possibility of amplifying such pulses in a polarisation-maintaining tapered fibre having 32 μm mode diameter at the output end. Highly chirped pulses with a repetition rate of 14.3 MHz and a duration of 10 ps at 1055 nm centre wavelength are amplified in an all-fibre circuit to 2.11 μJ energy and compressed by diffraction gratings to a duration of ∼297 fs. Reducing the pulse repetition rate to 1 MHz allows a 16.5 μJ output pulse energy to be achieved without manifestations of SRS and self-phase modulation in the spectrum.
|
2022-07-23T10:36:00.519Z
|
15,852,164 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TIP.2012.2192129",
"MAG": "2056339294",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We present a discrete unsupervised multiregion-competition algorithm for image segmentation over different energy functionals. The number of regions present in an image does not need to be known a priori, nor their photometric properties. The algorithm jointly estimates the number of regions, their photometries, and their contours. The required regularization is provided by defining a region as a connected set of pixels. The evolving contours in the image are represented by computational particles that move as driven by an energy-minimization algorithm. We present an efficient discrete algorithm that allows minimizing a range of well-known energy functionals under the topological constraint of regions being connected components. The presented framework and algorithms are implemented in the open-source Insight Toolkit image-processing library.
|
2022-12-12T21:20:16.624Z
|
195,696,534 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acs.jafc.9b01548",
"MAG": "2953916209",
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},
"license": null,
"status": null,
"url": null
}
|
Organophosphate esters (OPEs) are chemicals extensively used as plasticizers and flame retardants in commercial and consumer products. In this study, we developed and validated a method for the analysis of 13 common OPEs in meat (chicken, pork and beef) and fish (catfish and salmon) to study their occurrence in those foods in the USA. The method was based on QuEChERS extraction with acetonitrile and automated robotic cleanup of the extracts, followed by low pressure GC-MS/MS analysis for 8 of the OPEs and UHPLC-MS/MS analysis for 13 OPEs, including 8 overlapping OPEs. The developed method was validated in the muscle tissues at 4 spiking levels (5, 10, 20 and 40 ng/g). The background levels in the laboratory environment and materials presented a challenge to accurate quantification at low ng/g levels. UHPLC-Q-Orbitrap MS analysis was utilized to pinpoint the source of their contamination. OPEs were found in the water used in the LC mobile phase, and flow injection analysis with organic mobile phase was suggested as an alternative to avoid OPEs contamination in LC-MS/MS analysis. The validated method was applied to the analysis of 68 real-world meat and fish samples from the US markets by three instrumental methods. Tris (2-chloro-isopropyl) phosphate (TCPP), tri-n-butyl phosphate (TnBP), and tri-phenyl phosphate (TPP) were found in meat, and TCPP and TPP were measured in fish samples. The sum of median OPE concentrations (averaged for the three instrumental methods) measured in the meat and fish samples were 6.2 and 8.7 ng/g wet weight, respectively. No regulations on OPEs' maximum residue levels permitted in food were found for the USA or other countries.
|
2022-12-15T00:26:59.636Z
|
53,616,186 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5802/AIF.1807",
"MAG": "2319805123",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Nous calculons, en fonction des parametres arithmetiques decrits par Borel, les sous-groupes finis d'un groupe de Klein arithmetique maximal. Ceci est notamment appliquable a l'etude des 3-varietes arithmetiques hyperboliques.
|
2022-12-19T08:53:04.312Z
|
2,193,733 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7717/peerj.4207",
"MAG": "2782427361",
"PubMedCentral": "5755484"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.7717/peerj.4207"
}
|
Background Clear aligners are well known for facilitating oral hygiene maintenance and decreasing susceptibility to periodontal diseases as compared to conventional fixed appliances. However, few research studies focus on the subgingival microbial community during clear aligner treatment (CAT). Hence, this study investigates changes of the subgingival microbial community and its association with clinical characteristics during the first three months of CAT. Methods Ten female patients with clear aligners were enrolled in this study. Subgingival plaque samples were obtained at three time points: before orthodontic treatment (T0), one month after orthodontic treatment (T1) and three months after orthodontic treatment (T2). DNA was then extracted from plaque samples and analyzed by 16S rRNA gene sequencing. Periodontal examinations, including plaque index (PI) and gingival bleeding index (GBI) measurements were also recorded. Results The plaque indices (PIs) and gingival bleeding indices (GBIs) were slightly increased at T1 and T2, but no statistically significant difference was found. The alpha diversity indices, including the ACE, Chao1, Shannon indices, all showed a declining trend without significance, and a rising trend in the Simpson diversity index was observed. The weighted UniFrac distance was significantly higher at T1 and T2 compared with T0. Principal Coordinates Analysis (PCoA) demonstrated that the communities at T0 tended to cluster apart from the communities at T1 and T2. The relative abundance of the phylum Firmicutes and genus Mycoplasma was significantly increased at T0 compared with T2. There was no significant difference in the relative abundance of periodontal pathogens at the genus and species levels or core microorganisms at the genus level. Conclusion A slightly decreasing microbial diversity with a significant change of microbial structure was found during the first three-month clear aligner treatment (CAT). However, subjects receiving clear aligner treatment were free from periodontal diseases with relatively stable levels of periodontal microorganisms and core microorganisms. Thus, our preliminary findings indicated that clear aligners induced nonpathogenic changes of the subgingival microbiome in the first three-month treatment.
|
2022-12-24T17:20:45.378Z
|
10,013,972 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1118/1.4944593",
"MAG": "2325195286",
"PubMedCentral": null
},
"license": "CCBY",
"status": "HYBRID",
"url": "https://aapm.onlinelibrary.wiley.com/doi/pdfdirect/10.1118/1.4944593"
}
|
PURPOSE
Modern facilities for actively scanned ion beam radiotherapy allow in principle the use of helium beams, which could present specific advantages, especially for pediatric tumors. In order to assess the potential use of these beams for radiotherapy, i.e., to create realistic treatment plans, the authors set up a dedicated (4)He beam model, providing base data for their treatment planning system TRiP98, and they have reported that in this work together with its physical and biological validations.
METHODS
A semiempirical beam model for the physical depth dose deposition and the production of nuclear fragments was developed and introduced in TRiP98. For the biological effect calculations the last version of the local effect model was used. The model predictions were experimentally verified at the HIT facility. The primary beam attenuation and the characteristics of secondary charged particles at various depth in water were investigated using (4)He ion beams of 200 MeV/u. The nuclear charge of secondary fragments was identified using a ΔE/E telescope. 3D absorbed dose distributions were measured with pin point ionization chambers and the biological dosimetry experiments were realized irradiating a Chinese hamster ovary cells stack arranged in an extended target.
RESULTS
The few experimental data available on basic physical processes are reproduced by their beam model. The experimental verification of absorbed dose distributions in extended target volumes yields an overall agreement, with a slight underestimation of the lateral spread. Cell survival along a 4 cm extended target is reproduced with remarkable accuracy.
CONCLUSIONS
The authors presented a simple simulation model for therapeutical (4)He beams which they introduced in TRiP98, and which is validated experimentally by means of physical and biological dosimetries. Thus, it is now possible to perform detailed treatment planning studies with (4)He beams, either exclusively or in combination with other ion modalities.
|
2022-12-30T18:52:01.317Z
|
72,944,089 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1590/S0864-34662008000400015",
"MAG": "2108125055",
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"license": null,
"status": null,
"url": null
}
|
Los propositos actuales de universalizar la formacion academica e investigativa para la obtencion de grados cientificos en el sector de la salud se unen a los procesos de universalizacion de la educacion medica cubana y responden a la necesidad del sector de solucionar los problemas de salud con la aplicacion del metodo cientifico. Los actuales escenarios de la atencion primaria y secundaria son verdaderos espacios docentes e investigativos que permiten alcanzar este encargo de la Universidad Medica. La universalizacion de la formacion de doctores en el area de la salud se encuentra favorecida por la voluntad politica del Estado Cubano, en el propio pensamiento del Comandante en Jefe quien ha apuntado que estamos llamados a alcanzar un alto desempeno en los servicios mostrado por los profesionales de la salud en el pais y en todas las misiones internacionalistas. En este trabajo se expone la estrategia trazada por el Ministerio de Salud Publica de Cuba en aras de intensificar la formacion de doctores en ciencia en el sector y se exponen los resultados alcanzados en el doctorado en ciencias de la salud, como un ejemplo de todo lo que se esta haciendo en el pais.
|
2022-01-27T06:25:17.794Z
|
60,529,642 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/FIE.1997.636030",
"MAG": "1832966823",
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},
"license": null,
"status": null,
"url": null
}
|
Summary form only given. Beginning with the graduating class of 1990, the Rose-Hulman Institute of Technology Computer Science degree has had an eight credit requirement in the practice of software engineering. This presentation is a summary of seven years of the author's experience as facilitator for this requirement.
|
2022-02-11T15:49:25.480Z
|
236,548,289 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.36074/LOGOS-30.04.2021.V2.28",
"MAG": "3162384832",
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},
"license": null,
"status": null,
"url": null
}
|
У публікації висвітлено основні аспекти науково-методичного супроводу професійної діяльності педагогічних працівників закладів професійної (професійно-технічної) освіти. Зазначено необхідність внесення коректив у проєктування траєкторії професійного розвитку викладачів та майстрів виробничого навчання. Описано інноваційні моделі професійного розвитку педагогів.
|
2022-10-14T01:21:19.279Z
|
119,821,520 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1088/0954-3899/30/1/056",
"MAG": "1973373313",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Theoretical aspects of the structure of strange quark matter and neutron stars are discussed. Recent observations of thermal emissions from compact objects have been used to limit their radiation radii, defined by R∞ = R/1 - 2GM/Rc 2 . Although x-ray observations suggest anomalously small radii, consistent with strange quark matter stars, spectral observations over a broader wavelength range also admit a normal neutron star interpretation. Structures of strange quark and neutron stars are contrasted using known analytic solutions of the relativistic structure equations. These are compared to numerical models utilizing various realistic equations of state for strange quark and nucleonic matter. Potentially observable quantities, such as moments of inertia and binding energies, are discussed. Such comparisons highlight the importance of direct radius measurements. Measurements of quark or neutron star masses also have the potential of setting an upper limit to the energy density in any compact object. Ultimately, such measurements could constrain the possibility of deconfined strange quark matter.
|
2022-12-02T00:52:47.720Z
|
243,460,362 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21203/rs.2.22148/v1",
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"PubMedCentral": null
},
"license": "CCBY",
"status": "GREEN",
"url": "https://www.researchsquare.com/article/rs-12726/v1.pdf"
}
|
Background A growing body of evidence suggests that early life health and developmental outcomes can be improved through parental support programs. The objective of this project was to test the feasibility, impact, and relative cost-effectiveness of an adapted “Reach Up and Learn” program delivered through home visiting programs as well as through center-based parenting groups on child health and development in the municipality of Boa Vista, Brazil. Methods A randomized stepped wedge design was used to roll out and evaluate the two parenting platforms in Boa Vista municipality. A total of 39 neighborhoods with high vulnerability index were selected for the study. For the first phase of the program, 9 neighborhoods were randomly selected for home visits, and 2 were randomly selected for the center-based parenting groups. In the second phase of the program, 10 neighborhoods were added to the home visiting program, and 8 were added to the center-based program. In the final phase of the program, the remaining 10 control areas will also be assigned to treatment. Study eligibility will be assessed through a baseline survey completed by all pregnant women in the 39 study areas. Pregnant women will be eligible to participate in the study if they are either classified as poor, were under age 20 when they became pregnant, or if they indicate to have been exposed to domestic or sexual violence. To assess program impact, an endline survey will be conducted when children reach age 2. The primary study outcome is child development at age 2 as measured by the PRIDI instrument. Secondary outcome will be infant mortality, which will be assessed linking municipal vital registration systems to the program rollout. Discussion This trial will assess the feasibility and impact of parenting programs rolled out at medium scale. The results from trial should create evidence urgently needed for guiding Brazil’s national Criança Feliz program as well as similar efforts in other countries.
|
2022-12-17T04:49:25.845Z
|
94,126,068 |
{
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"ArXiv": null,
"DOI": "10.1021/LA981008D",
"MAG": "1981694065",
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"status": null,
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}
|
The effects of humidity and temperature on tribological properties of mica and of the octadecyltriethoxysilane (OTE) monolayer self-assembled on mica are studied by friction force microscopy under controlled environments. As the humidity increases, the friction force is observed to decrease for mica and to increase for OTE at low loads at room temperature. Despite their hydrophobicity, water can penetrate into OTE films to alter their molecular chain ordering and to detach the OTE molecules from the mica substrate. The occurrence of OTE film damage is manifested as a crossover point in the friction force curves. Heating the samples in the temperature range of 20−80 °C induces a negligible effect for both mica and OTE in low humidity. However, in high humidity, a distinctive change in friction was found. Most of the heating effect can be understood by a “local humidity” concept although various discrepancies still exist.
|
2022-12-17T09:55:50.852Z
|
209,428,101 |
{
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"ArXiv": null,
"DOI": "10.1002/oby.22657",
"MAG": "2996503447",
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},
"license": null,
"status": "CLOSED",
"url": null
}
|
Emissions of greenhouse gases (GHG) are linked to global warming and adverse climate changes. Meeting the needs of the increasing number of people on the planet presents a challenge for reducing total GHG burden. A further challenge may be the size of the average person on the planet and the increasing number of people with excess body weight. We used data on GHG emissions from various sources and estimated that obesity is associated with ~20% greater GHG emissions compared with the normal‐weight state. On a global scale, obesity contributes to an extra GHG emissions of ~49 megatons per year of CO2 equivalent (CO2eq) from oxidative metabolism due to greater metabolic demands, ~361 megatons per year of CO2eq from food production processes due to increased food intake, and ~290 megatons per year of CO2eq from automobile and air transportation due to greater body weight. Therefore, the total impact of obesity may be extra emissions of ~700 megatons per year of CO2eq, which is about 1.6% of worldwide GHG emissions. Inasmuch as obesity is an important contributor to global GHG burden, strategies to reduce its prevalence should prioritize efforts to reduce GHG emissions. Accordingly, reducing obesity may have considerable benefits for both public health and the environment.
|
2022-12-15T18:41:22.055Z
|
15,783,942 |
{
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"ArXiv": null,
"DOI": "10.1145/2578260.2578270",
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"license": null,
"status": null,
"url": null
}
|
Video streaming is a major source of Internet traffic today and usage continues to grow at a rapid rate. To cope with this new and massive source of traffic, ISPs use methods such as caching to reduce the amount of traffic traversing their networks and serve customers better. However, the presence of a standard cache server in the video transfer path may result in bitrate oscillations and sudden rate changes for Dynamic Adaptive Streaming over HTTP (DASH) clients. In this paper, we investigate the interactions between a client and a cache that result in these problems, and propose an approach to solve it. By adaptively controlling the rate at which the client downloads video segments from the cache, we can ensure that clients will get smooth video. We verify our results using simulation and show that compared to a standard cache our approach (1) can reduce bitrate oscillations (2) prevents sudden rate changes, and compared to a no-cache scenario (3) provides traffic savings, and (4) improves the quality of experience of clients.
|
2022-12-22T16:49:44.726Z
|
1,838,818 |
{
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"DOI": "10.1097/00006842-195707000-00008",
"MAG": "2315246552",
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"license": null,
"status": null,
"url": null
}
|
Summary Hippuric acid excretion was investigated in 20 schizophrenic and 15 depressive patients before and after E.C.T. Decreased excretion of hippuric acid was found in both groups before E.C.T. and this treatment rectified the defect in both groups to a comparable degree. Short‐acting correction of the deficient hippuric acid excretion could also be achieved by giving glycine at the same time as the sodium benzoate for the excretion test. This level of synthesis was not further improved by E.C.T. The fundamental metabolic disturbance expressed in our test measurements appeared to be of a similar nature in both groups of patients and to run parallel with states of severe withdrawal and psychomotor retardation. It did not seem to be important whether this state of withdrawal was part of a schizophrenic or of a depressive process. A possible pathway for the mechanism of the effect of E.C.T. has been discussed and the implications of these findings in relation to similar findings under physiological conditions have been considered.
|
2022-12-27T16:00:46.876Z
|
151,142,283 |
{
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"DOI": "10.21236/ada423734",
"MAG": "152134867",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
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|
Abstract : Fostering economic growth and prosperity in Sub-Saharan Africa (SSA) is important to our national interests. There has been very little improvement in the economic status of the average African since the end of colonial rule. Many African countries are poorer now than they were at the time of their independence. Problems with potential global impact such as failed states HIV/AIDS environmental degradation and endemic poverty and starvation continue to exist. As a nation the United States is at a critical juncture where it finds itself without peer and at times with a less than desirable image. As a result of improvements in technology communications and transportation many in the Third World realize that they are truly deprived and look to the U.S. for leadership and resolution. To be sure the U.S. cannot be all things to all nations but our continued good fortune will depend on international stability and the continued improvement of the human condition in disadvantaged regions. SSA is a critical link to international stability and in time our good fortune in the coming years. This paper will examine current U.S. economic strategy in SSA and attempt to assess its efficacy in improving the conditions in that region.
|
2022-02-09T03:31:58.593Z
|
94,350,291 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/C3TA11238A",
"MAG": "1965464735",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
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|
Antimony doped tin oxide (ATO) and its composites with carbon nanotubes (CNTs) were synthesized and investigated as alternative Pt catalyst supports for the oxygen reduction reaction (ORR) and the methanol oxidation reaction (MOR). The synthesized ATO nanoparticles had a BET surface area of 88 m2 g−1 and an electronic conductivity of 0.75 S cm−1. When loaded on the CNT surface at a content of e.g. 5 wt%, the composite support provided a specific surface area of 243 m2 g−1 and an electronic conductivity of 3.9 S cm−1. Uniformly dispersed platinum nanoparticles were prepared with this composite material as the support. Strong interactions between platinum and oxide particles, as evidenced by XPS, led to modification of the electronic structure of platinum, which in turn significantly enhanced the catalytic activity towards both ORR and MOR. The improved catalytic performance for the ORR was confirmed by high temperature proton exchange membrane fuel cell tests.
|
2022-12-29T17:04:45.956Z
|
196,517,978 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4067/S0034-98872018000200232",
"MAG": "2803083778",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
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|
Background: Title revalidation of foreign Medical graduates to practice medicine in Chile is a complex and expensive process. According to the legislation they are required to approve the Unique National Exam of Medical Knowledge (EUNACOM), which has a theoretical and a practical section. Aim: To demonstrate that a collaborative and standardized examination of the practical section of EUNACOM is more effective and efficient than traditional practical examinations. Material and methods: The faculties of Medicine of the Catholic University of Chile, University of Chile and University of Concepcion were associated to implement an examination proposal, framed in the legislation. The EUNACOM board supported and funded the initiative which consisted in the implementation of Objective Structured Clinical Examination (OSCE) for each basic specialty of medicine, applied to 40 designated candidates. This format was selected because of the wide experience and evidence at the international level in the certification of medical professionals. Results: A collaborative and standardized OSCE reduces to less than half the time spent by examiners, providing more evidence of validity, reliability and objectivity. It also allows to visualize the real costs per applicant, which proved to be higher than those currently charged by EUNACOM, but comparatively lower than the examination used in the United States. Conclusions: A collaborative OSCE responds to the ethical principle of justice by being more valid, reliable, objective and cost efficient.
|
2022-05-13T00:14:46.638Z
|
220,412,078 |
{
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"DOI": "10.1097/BOT.0000000000001878",
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"license": null,
"status": null,
"url": null
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|
OBJECTIVE
To assess the use of Ketotifen Fumarate (KF) to reduce post-traumatic contractures following elbow fractures and/or dislocations.
DESIGN
Randomized clinical trial.
SETTING
Three hospitals in Calgary, Canada including one Level 1 trauma center.
PARTICIPANTS
Adults (n=151) sustaining operative or non-operatively managed isolated distal humerus or proximal radius +/- ulna fractures or elbow dislocations within seven days of injury.
INTERVENTIONS
KF 5 mg (n=74) or lactose-Placebo (PL, n=77) orally twice daily for six weeks.
MAIN OUTCOMES
Primary outcome elbow flexion-extension arc range of motion (ROM) at 12 weeks post-randomization. Safety measures including serious adverse events (SAE) and radiographic fracture line disappearance from 2 to 52 weeks post-randomization.
RESULTS
The elbow ROM (mean, confidence interval) was not significantly different between KF (122°, 118°-127°) and PL (124°, 119°-130°) groups (p=0.56). There was a significant difference in elbow ROM at 12 weeks post-randomization comparing operative (117°, 112°-122°) vs non-operative groups (128°, 124°-133°) irrespective of intervention (p=0.0011). There were 11 SAE (KF=6, PL=5) that were those expected in an elbow fracture population potentially taking KF. There was no statistically significant difference in the rates of these events between the groups. The disappearance of fracture lines over time was similar between groups. There was one non-union in each group.
CONCLUSIONS
In a population of operative and non-operatively managed elbow fractures and/or dislocations KF did not reduce post-traumatic contractures. The administration of KF in this population was not found to result in a significantly higher number of major adverse events when compared to placebo.
LEVEL OF EVIDENCE
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
|
2022-06-16T20:45:55.158Z
|
24,623,739 |
{
"externalids": {
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"DOI": "10.1200/JCO.2006.24.18_SUPPL.10661",
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"license": null,
"status": null,
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|
10661 Purpose: The aim of the study is to evaluate the safety and feasibility of radical brachytherapy for accelerated partial breast irradiation (APBI) and to study the outcome with respect to local control and survival.
MATERIALS AND METHODS
During May 2000 to December 2004, 115 women participated in the ongoing prospective study of APBI using interstitial brachytherapy as the sole modality of radiation for early breast cancer. Women with age > 40 years, single tumour up to 3 cm without diffuse microcalcification and clinically negative axilla were considered suitable. Brachytherapy was done either intraoperatively during the breast conserving surgery or postoperatively using 2-4 planes. Tumor bed demarcation was done with radiopaque clips placed during surgery, CT scans, ultrasonography and/or fluoroscopy. Cavity with 1cm margin was treated based on orthogonal pair of X rays to a dose of 34 Gy in 10 fractions over 1 week with twice daily fractionation using high dose rate iridium source.
RESULTS
Implant was done postoperatively in 35 patients while in remaining patients it was done intraoperatively. Implant procedure was tolerated well by all the patients. In 8 patients only 3 or 4 fractions of HDR Brachytherapy were delivered and this was followed by 45 Gy/25 # whole breast radiation therapy for following reasons: positive nodes (4), EIC positive (3) and poor implant coverage (1). At a median follow up of 23 months, the actuarial local control rate is 100%. Three year actuarial disease free survival is 93% while the overall survival is 100%. Complications included fat necrosis in 5 and wound gape in 4 patients. Cosmesis was good to excellent in 60% of the patients.
CONCLUSION
In this ongoing prospective study, APBI using radical interstitial implant was well tolerated and appears to be safe and feasible in appropriately selected patients. Further follow up is needed for confirm the long term safety of the procedure. No significant financial relationships to disclose.
|
2022-09-02T09:35:16.500Z
|
15,791,782 |
{
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"DOI": "10.1109/ICTON.2011.5970848",
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},
"license": null,
"status": null,
"url": null
}
|
It is a challenge to break up the wavelength into smaller sub-wavelength parts for optical network. The sub-wavelength switch (OSS) can be realized employing time and space division multiplexing, and orthogonal frequency division multiplexing among others. In the industry side, automatic switched optical network (ASON) based on synchronous digital hierarchy (SDH) is widely employed in the backbone network. The first part of this paper discusses the highly dynamic performance of ASON switched connections with measurement and standardization effort. In the academic side, on the other hand, optical packet switch (OPS) attracts more attention as a long term evolution of optical network. The second part of this paper discusses the efficient aggregation of IP packets into the optical packet. The gap between the lengths of optical packet and switched connection duration are discussed.
|
2022-09-10T00:37:20.834Z
|
125,227,741 |
{
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"DOI": "10.7287/PEERJ.PREPRINTS.2693V1",
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"license": null,
"status": null,
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|
This document is my attempt at distilling some of the information in two papers published by Anthony Nicholls (J. Comput. Aided Mol. Des. 2014, 28, 887; ibid 2016, 30, 103). Anthony also very kindly provided some new equations, not found in the papers, in response to my questions. The paper describes how one determines whether the difference in accuracy of two methods in predicting some properties for the same data set is statistically significant using root-mean-square errors, mean absolute errors, mean errors, and Pearsons r values. Introduction This document is my attempt at distilling some of the information in two papers published by Anthony Nicholls [1, 2]. Anthony also very kindly provided some new equations, not found in the papers, in response to my questions. Errors also have error bars Say you have two methods, A and B, for predicting some property and you want to determine which method is more accurate by computing the property using both methods for the same set of N different molecules for which reference values are available. You evaluate the error (for example the RMSE) of each method relative to the reference values and compare. The point of this post is that these errors have uncertainties (error bars) that depend on the number of data points (N , more data less uncertainty) and you have to take these uncertainties into consideration when you compare errors. The most common error bars reflect 95% confidence and that’s what I’ll use here. The expression for the error bars assume a large N where in practice "large" in this context means roughly 10 or more data points. If you use fewer points or would like more accurate estimates please see the Nicholls papers for what to do. Root-Mean-Square-Error (RMSE) The error bars for the RMSE are asymmetric. The lower and higher error bar on the RMSE for method X (RMSEX) is LX = RMSEX − √ RMSE2 X − 1.96 √ 2RMSE2 X √ N − 1 = RMSEX 1− √ 1− 1.96 √ 2 √ N − 1 1 PeerJ Preprints | https://doi.org/10.7287/peerj.preprints.2693v1 | CC BY 4.0 Open Access | rec: 3 Jan 2017, publ: 3 Jan 2017 UX = RMSEX √1 + 1.962 √ N − 1 − 1 Mean Absolute Error (MAE) The error bars for the MAE is also asymetric. The lower and higher error bar on the MAE for method X (MAEX) is LX = MAEX 1− √ 1− 1.96 √ 2 √ N − 1 UX = MAEX √1 + 1.962 √ N − 1 − 1 Mean Error (ME) The error bars for the mean error are symmetric and given by LX = UX = 1.96sN √ N where sN is the standard population deviation (e.g. STDEVP in Excel). Pearson’s correlation coefficient, r The first thing to check is whether your r values themselves are statistically significant, i.e. rX > rsignificant where rsignificant = 1.96 √ N − 2 + 1.962 The error bars for the Pearson’s r value are asymmetric and given by LX = rX − e− − 1 e2F− + 1 UX = e+ − 1 e2F+ + 1 − rX where F± = 1 2 ln 1 + rX 1− rX ± rsignificant Comparing two methods If errorX is some measure of the error, RMSE, MAE, etc, and errorA > errorB then the difference is statistically significant only if errorA − errorB > √ LA + U 2 B − 2rABLAUB where rAB is the Pearson’s r value of method A compared to B, not to be confused with rA which compares A to the reference value. Conversely, if this condition is not satisfied then you cannot say that method B is not more accurate than method A with 95% confidence because the error bars are too large. 2 PeerJ Preprints | https://doi.org/10.7287/peerj.preprints.2693v1 | CC BY 4.0 Open Access | rec: 3 Jan 2017, publ: 3 Jan 2017 Note also that if there is a high degree of correlation between the predictions (rAB ≈ 1) and the error bars are similar in size LA ≈ UB then even small differences in error could be significant. Usually one can assume that rAB > 0 so if errorA−errorB > √ LA + U 2 B or errorA−errorB > LA + UB then the difference is statistically significant, but it is better to evaluate rAB to be sure. The meaning of 95% confidence Say you compute errors for some property for 50 molecules using method A (errorA) and B (errorB) and observe that Eq 11 is true. Assuming no prior knowledge on the performance of A and B, if you repeat this process an additional 40 times using all new molecules each time then in 38 cases (38/40 = 0.95) the errors observed for method A will likely be between errorA − LA and errorA + UA and similarly for method B. For one of the remaining two cases the error is expected to be larger than this range, while for the other remaining case it is expected to be smaller. Furthermore, in 39 of the 40 cases errorA is likely larger than errorB , while errorA is likely smaller than errorB in the remaining case. Computer code Python code that determines statistical significance using RMSEs is available at https://github.com/jensengroup/statsig References [1] A. Nicholls. Confidence limits, error bars and method comparison in molecular modeling. part 1: The calculation of confidence intervals. Journal of Computer-Aided Molecular Design, 28(9):887–918, jun 2014. [2] A. Nicholls. Confidence limits, error bars and method comparison in molecular modeling. part 2: comparing methods. Journal of Computer-Aided Molecular Design, 30(2):103–126, feb 2016. 3 PeerJ Preprints | https://doi.org/10.7287/peerj.preprints.2693v1 | CC BY 4.0 Open Access | rec: 3 Jan 2017, publ: 3 Jan 2017
|
2022-09-16T03:48:10.959Z
|
5,780,798 |
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|
Abstract
|
2022-09-16T02:59:30.234Z
|
194,897,780 |
{
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"DOI": "10.1111/resp.13420_412",
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"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/resp.13420_412"
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|
flow limitation. A major site of airflow limitation in COPD is the small conducting airways. Small Airway Obstruction is a harbinger of COPD and abnormalities in the small airways in smokers may or may not have COPD. Thus the aim of the study is early detection of small airway obstruction and determine the Correlation of Forced Expiratory Flow (FEF) 25–75% and the number of pack-years among smokers. Methods: Patient with smoking history is included and demographic and spirometry result (FEV1/FVC, FVC, FEV1, FEF25-75) are collected. Cut-off value of smoking pack-years with low FEF25-75 was determine and correlation among patients with normal and low FEV1/FVC was done. Results: There was significant correlation of FEF 25–75 and smoking pack-years with inverse relationship (r = −0.35, P = 0.0014). The smoking pack-years cut-off value that will give low FEF25-75 was 16.5 smoking pack-years. Conclusion: FEF25-75 may be use for early detection of small airway obstruction. This may help encourage smokers to quit earlier before significant airway obstruction symptomatology occurs and prevent further progression to COPD and other complications of smoking.
|
2022-10-14T00:35:38.701Z
|
218,598,898 |
{
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"ArXiv": null,
"DOI": "10.1080/19420889.2020.1761069",
"MAG": "3018491546",
"PubMedCentral": "7202783"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/19420889.2020.1761069?needAccess=true"
}
|
ABSTRACT The trans-Golgi network (TGN) and recycling endosome (RE) have been recognized as sorting centers, the former for newly synthesized and the latter for endocytosed proteins. However, recent findings have revealed that TGN also receives endocytosed materials and RE accepts newly synthesized proteins destined to the plasma membrane. Recently, we reported that in both Drosophila and microtubule-disrupted HeLa cells, REs are associated with the trans-side of Golgi stacks. REs are highly dynamic: their separation from and association with Golgi stacks are often observed. Importantly, a newly synthesized cargo, glycosylphosphatidylinositol-anchored-GFP was found to be concentrated in Golgi-associated REs (GA-REs), while another cargo VSVG-GFP was excluded from GA-REs before post-Golgi trafficking to the plasma membrane. This suggested that the sorting of cargos takes place at the interface of Golgi stacks and GA-REs. In this study, we demonstrated that REs could associate with Golgi stacks in sea urchin embryos, further indicating that the association of REs with Golgi stacks is a well-conserved phenomenon in the animal kingdom.
|
2022-10-21T00:26:15.821Z
|
149,582,066 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.2737/NRS-GTR-P-187-PAPER6",
"MAG": "2941265735",
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},
"license": null,
"status": null,
"url": null
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|
Growing indigenous empowerment and recognition of rights with respect to natural resources was identified as an emerging trend in the USDA Forest Service-University of Houston Forest Futures Horizon Scanning system. An exploratory Implications Wheel® exercise was conducted to uncover possible future implications of this trend. The exercise was carried out with a group of University of Houston Foresight graduate students, faculty, and alumni. The exercise did not include American Indian or Alaska Native participants, and due to this limitation it should be viewed as an illustration of the usefulness of the method for exploring the implications of horizon scanning hits. A total of 175 first-, second-, and third-order implications were generated. Analysis of the implications found nine emerging themes and four scenarios. The findings reveal the wide range of significant possibilities that could result from growing indigenous empowerment and suggest the importance of monitoring this trend as it unfolds.
|
2022-11-04T00:34:44.454Z
|
31,110,745 |
{
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"DOI": "10.1111/j.1749-6632.1982.tb21416.x",
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"license": null,
"status": null,
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|
Yeast peroxisomes (microbodies) were first reported in the cells of Saccharomyces cerevisiae by Avers and her associates.'*2 Several enzymes, including catalase, were detected in these peroxisomes. However, on the average, no more than one peroxisome was present per section of yeast cell, and the metabolic function of the peroxisomes was not clarified. In addition, the question was raised whether S . cerevisiae peroxisomes might be vacuoles containing catalase A.3 During studies on the physiology and metabolism of alkane-utilizing yeasts, the existence of organelles surrounded by a single-unit membrane was discovered by the present authors?' The appearance and development of the organelles were related to alkane assimilation, and accompanied by a significant increase in the activity of catalase, a marker enzyme of peroxisomes. Localization of catalase in the organelles was demonstrated cytochemically by the use of 3,3'-diaminoben~idine.~.~ Although some researchers claimed that these organelles might be lipid inclusions" or lipid vacuole^,^ our studies on the cytochemical and biochemical properties provided conclusive evidence identifying them as peroxisomes. After our observation, the presence of peroxisomes in other alkane-utilizing yeast strains has been reported by several investigators."-" In addition to alkane-grown yeasts, appearance of peroxisomes in methanolgrown yeast cells was found independently by and German'' as well as Dutch groups.I6 This article summarizes the fundamental and practical aspects of peroxisomes of alkane-sssimilating yeasts with particular reference to their function in alkane metabolism. Some of the results to be presented here have been reviewed by the present author^.'^-^^
|
2022-12-16T01:48:06.624Z
|
90,709,406 |
{
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"DOI": "10.2210/pdb1cf1/pdb",
"MAG": "2787551746",
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},
"license": null,
"status": "CLOSED",
"url": null
}
|
G protein-coupled signaling is utilized by a wide variety of eukaryotes for communicating information from the extracellular environment. Signal termination is achieved by the action of the arrestins, which bind to activated, phosphorylated G protein-coupled receptors. We describe here crystallographic studies of visual arrestin in its basal conformation. The salient features of the structure are a bipartite molecule with an unusual polar core. This core is stabilized in part by an extended carboxy-terminal tail that locks the molecule into an inactive state. In addition, arrestin is found to be a dimer of two asymmetric molecules, suggesting an intrinsic conformational plasticity. In conjunction with biochemical and mutagenesis data, we propose a molecular mechanism by which arrestin is activated for receptor binding.
|
2022-12-23T05:30:15.551Z
|
13,352,247 |
{
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"DOI": "10.1073/pnas.1204729109",
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},
"license": "pd",
"status": "HYBRID",
"url": "https://www.pnas.org/content/pnas/109/50/20212.full.pdf"
}
|
This introduction to the Special Feature presents the context for science during the Deepwater Horizon oil spill response, summarizes how scientific knowledge was integrated across disciplines and statutory responsibilities, identifies areas where scientific information was accurate and where it was not, and considers lessons learned and recommendations for future research and response. Scientific information was integrated within and across federal and state agencies, with input from nongovernmental scientists, across a diverse portfolio of needs—stopping the flow of oil, estimating the amount of oil, capturing and recovering the oil, tracking and forecasting surface oil, protecting coastal and oceanic wildlife and habitat, managing fisheries, and protecting the safety of seafood. Disciplines involved included atmospheric, oceanographic, biogeochemical, ecological, health, biological, and chemical sciences, physics, geology, and mechanical and chemical engineering. Platforms ranged from satellites and planes to ships, buoys, gliders, and remotely operated vehicles to laboratories and computer simulations. The unprecedented response effort depended directly on intense and extensive scientific and engineering data, information, and advice. Many valuable lessons were learned that should be applied to future events.
|
2022-12-28T18:23:37.120Z
|
244,707,120 |
{
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"DOI": "10.17816/mser71135",
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"license": null,
"status": "GOLD",
"url": "https://doi.org/10.17816/mser71135"
}
|
Human health and well-being largely depend on a sufficient standard of living, educational opportunities and participation in social and social life, and successful professional activities. It should be recognized that in the surrounding society it is in these areas of life that people with disabilities and disabilities are especially disadvantaged, but not neglected by society and the state.
Currently, in the Russian Federation, the State programme Accessible Environment is being implemented to support and assist persons with disabilities and disabilities, with the aim of creating legal, economic and institutional conditions conducive to the integration of persons with disabilities into society and improving their quality of life. The programme contains three subprogrammes that are effectively implemented in modern society, namely: (1) Ensuring the accessibility of priority facilities and services in priority areas of life of persons with disabilities and other mobile populations; (2) Improvement of the system of comprehensive rehabilitation and habilitation of persons with disabilities; (3) Improvement of the state system of medical and social expertise.
The organizers of the Abilimpix social movement were able to demonstrate to people with disabilities their individual capabilities and prospects for accessibility to all types, forms and means of obtaining knowledge and professional skills, their effective application in practice.
|
2022-01-22T03:25:09.751Z
|
244,137,811 |
{
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"DOI": "10.30656/jpmwp.v5i2.3302",
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},
"license": "CCBYSA",
"status": "HYBRID",
"url": "https://e-jurnal.lppmunsera.org/index.php/parahita/article/download/3302/1829"
}
|
Kegiatan pengabdian masyarakat ini bertujuan untuk menggali potensi dan peluang yang dapat dimanfaatkan oleh masyarakat sekitar Kawasan Banten Lama melalui socialpreneurship. Pemanfaatan sumber daya alam (pembuatan cinderamata berbahan kerang) dan peningkatan kapasitas sumber daya manusia baik masyarakat sekitar, maupun kelompok sadar wisata (pokdarwis). Tour Guide Local memiliki point penting dalam memberikan informasi terkait historical Banten Lama yang dapat menjadi sebuah cara dalam menginformasikan nilai sejarah melalui program edu-tourism. Keterlibatan setiap pihak dalam program kemitraan harus bekerja sama agar kawasan Banten Lama memiliki daya tarik baik tingkat lokal, nasional maupun mancanegara.
|
2022-01-27T09:01:15.106Z
|
197,187,291 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/CHIN.201426008",
"MAG": "2953322358",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Layered BiIO4/Bi2WO6 (2, 5, 10, and 15%) heterojunctions are prepared by hydrothermal processing of an aqueous suspension of Bi(NO3)3 and a I2O3, Na2WO4 solution (autoclave, 180 °C, 1 d).
|
2022-02-08T06:42:35.150Z
|
10,034,301 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4304/jcp.9.8.1776-1786",
"MAG": "1990557898",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Arsenic contamination of groundwater in many nations including Bangladesh shows that this is a global problem. Because of the delayed health effects, poor reporting, and low levels of awareness in some communities, the extent of the adverse health problems caused by arsenic in drinking water is at alarming level in Bangladesh. Also, allocating resources such as tube wells efficiently and effectively to mitigate arsenic hazard is a challenging task in Bangladesh. To allocate resources based on different arsenic hazard parameters, we have developed a Decision Support System that enables the user to observe the effect of allocation policy both in tabular and spatial format using statistical models. We have also developed an algorithm for optimal allocation of resources. A Smart User Interface is designed for the users so that they will find an interactive, user-friendly, intelligible, logical, clear, and sound environment to work with. Finally, we have analyzed and demonstrated the efficacy of our algorithm graphically.
|
2022-02-13T06:53:55.455Z
|
109,796,586 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17776/CSJ.505746",
"MAG": "2922798963",
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"license": null,
"status": null,
"url": null
}
|
Polimerik elektroegirme lifler, yara iyilesme uygulamalari icin iyi tasarimli iskeleler sunmaktadir. Burada, kurkumin (Cur) iceren biyobazli poliuretan (PU) karisim liflerin uretimi rapor edilmektedir. Y alnizca polimer konsantrasyonu degil, ayni zamanda kurkumin konsantrasyonu, fiberlerin morfolojisi, capi ve temas acisi degerlerini etkilemistir. Morfolojik arastirmalar, PU liflerinin capinin ve hidrofilikliginin kurkumin ilavesi uzerine arttigini ortaya koymustur. Proses parametrelerinin (uygulanan voltaj, akis hizi ve uctan toplayiciya mesafe) PU ve PU/Cur liflerinin ortalama cap ve hidrofilikligi uzerindeki etkileri incelenmistir. Homojen ve boncuksuz PU/Cur lif elde etmek icin optimum kosullar 12.5 kV, 1 mL/s ve 17 cm olarak belirlenmistir. Bu calisma, elektroegirme isleminin, biyoaktif madde yuklu lifli iskeleleri elde etmenin basit bir yolunu saglamasinin yani sira, PU/Cur karisim liflerinin imalatinda yara iyilesmesi uygulamalari icin islem degiskenlerinin etkisinin daha iyi anlasilmasina katkida bulundugunu gostermektedir.
|
2022-08-24T16:43:33.973Z
|
25,702,019 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1259/bjr/91234292",
"MAG": "2053113812",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This meeting was convened by COST (Co-operation in the Field of Scientific and Technical Research) and ENLIGHT (European Network for Research in Light-Ion Hadron Therapy) to review the current status of hadron therapy in Europe. The aims were to increase awareness of hadron therapy within the scientific community, to produce a document outlining the present and future prospects for this treatment modality and to bring together hadron therapy scientists and clinicians. Proton therapy offers the potential for therapeutic gain from dose distribution advantages when compared with photon therapy. Carbon ion therapy, by nature of its higher linear energy transfer (LET) and relative biological effectiveness (RBE), may further improve local control. A further potential benefit of carbon ion therapy is the ability to deliver hypofractionated radiotherapy. A further aim of this meeting was to commence preparation of a programme of work packages with a view to submitting an application for European Union funding within the FP7 programme. This comprises a series of seven work packages, which will be a focus for European collaboration.
|
2022-12-11T12:32:46.228Z
|
6,707,212 |
{
"externalids": {
"ACL": null,
"ArXiv": "0802.3654",
"DOI": "10.1214/ECP.V13-1359",
"MAG": "2949540863",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We investigate the relation between the local picture left by the trajectory of a simple random walk on the torus $({\mathbb Z} / N{\mathbb Z})^d$, $d \geq 3$, until $uN^d$ time steps, $u > 0$, and the model of random interlacements recently introduced by Sznitman. In particular, we show that for large $N$, the joint distribution of the local pictures in the neighborhoods of finitely many distant points left by the walk up to time $uN^d$ converges to independent copies of the random interlacement at level $u$.
|
2022-12-23T07:42:00.055Z
|
232,103,815 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acsami.1c01006",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Glucose oxidase (GOx) is regarded as an ideal endogenous natural enzyme for tumor starvation therapy and photothermal therapy (PTT) is a promising strategy for the ablation of primary tumor. In this work, Cu-doped cobalt oxide and porous carbon nanocomposites (CuCo(O)@PCNs) were synthesized from double-layered ZIF-8@ZIF-67 and GOx was loaded in the porous carbon to form a CuCo(O)/GOx@PCNs hybrid nanozyme. CuCo(O) was characterized as the Cu0.3Co2.7O4 phase through X-ray diffraction analysis and it can react with H2O2 to generate O2 and alleviate tumor hypoxia, resulting in the recovered enzymatic activity of GOx and the enhanced starvation therapy. The porous nanocarbon can ablate the primary tumor because of its high photothermal conversion efficiency of 40.04%. The three-in-one functions of oxygen supply, glucose consumption, and photothermal conversion were realized in the ZIFs-derived CuCo(O)/GOx@PCNs nanozyme and the starvation therapy effect was improved by PTT and oxygen supplement. Furthermore, the inhibition effect of CuCo(O)/GOx@PCNs on metastatic tumor is similar to combined therapy of the nanozyme and the immune checkpoint-blocking antibody, α-PD-1. The related antitumor immune mechanism was studied through the analysis of immune-related proinflammatory cytokines and the activated T cells. This work may provide new ideas for the development and application of the ZIFs-derived hybrid nanozyme in tumor therapy and the CuCo(O)/GOx@PCNs nanozyme may be a promising alternative to immune checkpoint inhibitors.
|
2022-12-28T18:14:29.195Z
|
144,501,590 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/001946467601300308",
"MAG": "2038741889",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The authors have reported on their study of health and health policies in a Tamil village, Thaiyur, situated about 20 miles south of Madras City. The first few pages discuss the content of sociological terms and diseases as social phenomena, mostly on theoretical lines. Then there is the usual description of the area, the population covered, the disease panorama and the facilities available. The importance of infectious and parasitic diseases, which account for 63 per cent of the causes of death, has been stressed. A discussion of the nutrition gap follows with the conclusion that ’‘feeding programmes cannot be substituted for a radical transformation of the system of food production.&dquo; The authors state that the people of Thaiyur would benefit much from drinking boiled water, but they do not boil it mainly because of its bad taste. They further reccmmend scenting the water to remove the bad taste. One would imagine, however, that the cost of fuel is the more obvious reason :
|
2022-02-09T06:57:58.230Z
|
19,200,844 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/EURAD.2005.1605614",
"MAG": "2084165468",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The aim of this paper is to present to the UWB community the SAW (surface acoustic waves) technology and its ability to propose, today and without hard investments, smart solutions for the RF physical layer of UWB systems whatever the concept is : direct sequence, MB-OFDM or chirp spread spectrum. The paper suggests concrete examples of SAW-based solutions : group delay equalizer, real time Fourier transform or pulse compression technique. These solutions are potentially small size, low cost, low power consumption, and immediate availability. The main concern is acceptance of these analog solutions in an all-digital oriented world
|
2022-02-12T23:15:52.616Z
|
99,761,293 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1201/b12522-10",
"MAG": "2511222978",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Oxidised acid sulfate soils contain significant quantities of potentially mobilised arsenic that may present a hazard to water quality. We evaluated the soluble arsenic concentrations and chemical speciation at a pasture field site (permanently used for cattle grazing) in Murwillumbah, NSW, during a rain event in November-December 2011. The results will quantify the risk of arsenic in acid sulfate environments, identify relationships between arsenic concentrations and ambient water chemistry for risk management.
|
2022-02-10T11:36:31.434Z
|
237,771,598 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/5.0047430",
"MAG": "3178352119",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
In this paper, we demonstrate the ferroelectric gate control of Rashba–Dresselhaus spin–orbit coupling (R–D SOC) in a hybrid heterostructure consisting of a ferromagnetic semiconductor channel (Zn, Co)O(0001) and a ferroelectric substrate PMN-PT(111). The R–D SOC causes a transverse spin current via the charge-spin conversion, which results in unbalanced transverse spin and charge accumulations due to the spin-polarized band in the ferromagnetic (Zn, Co)O channel. By the reversal of gated ferroelectric polarization, we observed 55% modulation of the R–D SOC correlated Hall resistivity to the magnetization correlated anomalous Hall resistivity and 70% modulation of the low-field magnetoresistance at 50 K. Our experimental results pave a way toward semiconductor-based spintronic-integrated circuits with an ultralow power consumption in ferromagnetic semiconductors.
|
2022-01-27T01:51:07.467Z
|
6,096,876 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/JAMA.1992.03480040055016",
"MAG": "2081348921",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
To the Editor. —In the article by Phibbs et al, 1 "The Neonatal Costs of Maternal Cocaine Use," the abstract did not adequately reflect the results presented in the article. In the results section of the abstract, the authors state that the cost of neonatal care until medically cleared for discharge was significantly higher for cocaine-exposed than for non-cocaine-exposed infants. This leaves the reader to assume that cocaine exposure is the factor that explains the impressive difference. However, the two populations compared in the study (cocaine-exposed and non-cocaine-exposed) differed in several important ways. These included use of other substances, adequacy of prenatal care, smoking, racial composition, age, and gravidity of mothers. Each of these variables could be important confounders and (as the authors rightly demonstrated) should be controlled in drawing conclusions as to the effect of the cocaine exposure itself. In the body of the text the authors are
|
2022-08-27T07:55:13.967Z
|
168,485,892 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/ssrn.2873299",
"MAG": "2553853270",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper studies the deterrence of governmental environmental regulation from the perspective of peer effect. With the financial data of listed companies and firm-level penalties manually collected in the period between 2007 and 2015, the Heckman model is adopted to test the deterrence from the target firms to peer firms, the empirical results show that government environmental regulation has deterrent effect, increasing the environmental protection investment of penalized firms and the peer firms. Considering the characteristics of target penalized firms and the penalty, when the target penalized firm is of big size, severely punished or reported, the deterrence effect to peer firms is much stronger. Specially, the industry competition can strengthen the deterrence effect. Therefore, the government should improve the certainty, typicality and severity of punishments, strengthen the informal supervision institution, such as public opinion, in the implementation of environmental regulation, and market-oriented reforms in China can strengthen the effectiveness of environmental regulation via competition.
|
2022-09-07T18:46:09.479Z
|
44,282,157 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CLEO.1997.602246",
"MAG": "2144129246",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We discuss the application of diffraction theory to the reshaping of freely propagating terahertz pulses by narrow apertures. This is accomplished by using two separate electrooptic sampling detectors. The first contains a narrow electrode geometry that does not modify the frequency content of the incident terahertz field, while the second contains a narrow gap between two large electrodes. The latter detector transforms the incident bipolar terahertz waveform into a unipolar waveform. We find that diffraction theory properly accounts for this reshaping process. We discuss the applicability of alternate electrode geometries for terahertz pulse shaping.
|
2022-09-22T19:19:49.151Z
|
73,448,452 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1094/PDIS-09-13-0960-PDN",
"MAG": "2018589275",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Pear tree (Pyrus communis) is an important crop in Greece. In 2012, fruits of the pear cv. Kontoula were observed in commercial fields located in Tirnavos, Prefecture of Larrisa, Greece, with symptoms of well-defined brown angular margins and their grayish white centers in which a few pycnidia (about 180 × 150 μm) were produced within the spots. Pycnidia were dark, separate, and globe-shaped with an ostiole (opening at the apex) from which conidia (about 40 to 60 × 3 μm) were extruded, and erupted through the surface of the infected tissue. Conidia were produced on short conidiophores. They were clear, narrowly elongated to filiform, and several-celled. The pathogen was isolated on acidified-PDA (2.5 ml 85% lactic acid per liter of nutrient medium) and incubated at 23°C for 7 days. The pathogen was identified as Septoria pyricola Desm. based on morphological characteristics. Koch's postulates were completed in the laboratory by placing a 40-μl drop of suspension (4 × 105 conidia ml-1 of water) on a wounded area of healthy fruits of cv. Kontoula. Fruits were surface sterilized with dipping in 0.1% chlorine solution, allowed to dry in a laminar flow hood. There were 15 inoculated and 15 control fruits (similarly inoculated with sterile distilled water) in a randomized design. Fruits were covered with perforated polythene bags to maintain a high humidity necessary for infection and these bags were removed 48 h after inoculation and maintained at room temperature (23 ± 2°C). Lesion development was recorded daily for each fruit. Koch's postulates were satisfied after re-isolating the fungus from inoculated fruit that developed symptoms similar to those observed on fruits collected from fields. Symptoms of this disease were found in all pear orchards cultivating the cv. Kontoula located in Tyrnavos (a municipality in the Prefecture of Larissa). Symptoms of septoria leaf spot were also observed in the above pear orchards. In contrast, no symptom of septoria fruit spot and septoria leaf spot was observed in apple orchards of the above regions. To our knowledge, this is the first report of the occurrence of S. pyricola as causal agent of fruit spot of pears in Greece. Fruit spotting is relatively uncommon; nevertheless, Sivanesan (3) gives two reports of conidia infecting pear fruits from Italy and South Africa (1,2). References: (1) G. Florenzano. Int. Bull. Plant Prot. 20:17, 1946. (2) A. J. Louw. Farming in South Africa 23:737, 1948. (3) A. Sivanesan. IMI Descriptions of Fungi and Bacteria, vol. 99, sheet 989. CABI, Wallingford, UK, 1990.
|
2022-11-18T01:14:56.178Z
|
156,297,183 |
{
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"ArXiv": null,
"DOI": "10.1353/chq.0.1067",
"MAG": "2340737133",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Patients who have received radiotherapy for malignant pelvic lesions may have complications appear years after treatment. One such case is described in which small bowel obstruction and fistuLl of ileum and bladder appeared 14 years after treatment. In addition, a case of vesicovaginorectal fistula appearing four years after termination of therapy and a case of hoemorrhage from multiple ulcers of the bowel coming on nine years after irradiation are also mentioned. Such complications may be indistinguiishable from those of recurrent malignant growth. If changes due to irradiation are found, it may be possible to restore the patient to health by surgical therapy.
|
2023-01-01T17:32:24.745Z
|
98,180,062 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.452887",
"MAG": "2058454717",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A redetermination of the quartic force field of the water molecule surface has been recently calculated by the method of Hoy, Mills, and Strey. A novel form of the bending coordinate has been introduced into this force field to ensure that the pure bending potential has the correct form at θ=π, and a few select force constant have been rerefined to the J=0 vibrational spectrum of H2O. The vibrational–rotational energy levels of the resulting surface have been determined by the variational method. Two particular sets have been examined: (i) low vibrational quanta, J≤9 and (ii) all levels below 12 000 cm−1 (relative to zero point), J≤2. The results are compared with the experimental levels in the literature.
|
2022-12-30T16:00:45.277Z
|
190,041,119 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1400/17969",
"MAG": "199255743",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Con poche modifiche, un kit per la ricezione della TV satellitare si trasforma in un efficiente ed economico radiometro a microonde in grado di misurare l’energia radiante, in questa regione dello spettro elettromagnetico, emessa dai corpi che ci circondano. Si realizza in tal modo un dispositivo in grado di verificare sia alcune delle proprieta tipiche delle microonde, come la loro capacita di attraversare la plastica, ma anche di stabilire che ci sono distinti processi di emissione delle onde elettromagnetiche, il piu importante dei quali e quello di origine “termica”, previsto dalla teoria del “corpo nero”. Si mostrera che tale processo e presente in ogni corpo, quindi anche in noi stessi, per il solo fatto di trovarsi ad una temperatura diversa dallo zero assoluto (0 K = -273 °C). Il radiometro proposto, le cui prestazioni vengono ampliate con un sistema automatico di acquisizione dati, condurra anche a delle osservazioni inaspettate: ad esempio, la forte emissione a microonde di una sorgente “fredda”, come puo essere una lampada a fluorescenza. Infine, puntando l’antenna del radiometro verso il cielo, lontano dalle zone dove sono collocati i numerosi satelliti artificiali, si potranno effettuare interessanti esperienze in campo radioastronomico. Questo inusuale strumento di misura si e dimostrato un efficace strumento didattico nel programma di fisica delle classi terminali di un Istituto Tecnico, ad un costo che, nelle sue parti essenziali, non ha superato la cifra di 50 euro.
|
2022-02-08T09:35:36.785Z
|
866,111 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/800293.811662",
"MAG": "1982064841",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://repository.lib.ncsu.edu/bitstream/1840.4/5979/1/1973_0092.pdf"
}
|
The study was conducted in the Basic Oxygen Furnace shop of a reputed steel company. Data were collected over extended periods to establish the statistical characteristics of daily liquid iron {hot metal) production from the blast furnaces, the life of refractory-lined vessels of the Basic Oxygen Furnace, and the heat-cycle time. This simulation generates total daily hot metal production from the specified distribution and determines the optimum combination of hot-metal-only charge (regular heat) and mixed charge (scrap and hot-metal or pre-heat) that will maximize ingot steel production within a fixed time period. The simulation takes into account the heat-cycle-time, the charge-mix, the number of heating-vessels available on the oxygen furnace, and the time required for relining of vessels. An iterative process using a modified form of the simplex algorithm with two constraints have been utilized in the simulation study for maximizing output. The output includes, on a daily basis, the hot-metal produced in tons, the number of vessels available, the number of regular-heats and pre-heats required for maximum steel production, steel production in tons, the amount to be pigged, and the amount available for the next day. The simulation provides the decision-maker in charge of the BOF operation with an operational discipline to maximize productivity and a reliable indicator to justify installation of scrap preheating facilities.
The entire simulation is written in Fortran IV, level G, and executed on an IBM 360 Model 65 computer.
|
2022-02-13T15:09:51.198Z
|
80,254,019 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/uog.18130",
"MAG": "2754066676",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
Objectives: To compare the acceptability of the techniques of vaginal examination (VE) and transperineal ultrasound (USS) techniques (transabdominal (TA) and transperineal (TP)) prior to delivery. Methods: 119 women 24-42 weeks gestation requiring a VE were consented as part of a prospective observational study April 2015-July 2016. The acceptability of both techniques was assessed pre and post examination using the modified Wijma-Delivery Experience Questionnaire, W-DEQ and the effect of Regional Analgesia (RA) was investigated. Experience scores in 6 domains: positive-trust and relax, negative-harmful to baby, worrying, painful, intrusive ranged from 6-36 (6 being most and 36 being least positive). Results: 115 women completed pre-assessment and 104 women completed both pre and post assessment questionnaires. Median age was 31(±5 SD), BMI 25kg/m2 (±4.6 SD), 89% of patients were nulliparous with median gestation 40+2 weeks (r25-42+1). 32% had RA at the time of assessment (91% for delivery). Pre-assessment median experience scores were 15 and 7 respectively (p<0.0001*), post-assessment were 12 versus 6 for VE versus USS respectively (p<0.0001*). The use of RA made no difference to the perceived experience pre-VE (p=0.9*). Post VE, women with RAs considered VEs more acceptable than did those without RA (p=0.0022*). For USS, the use of RA made no difference to the pre and post assessment scores (p=0.5370 vs. p=0.7739*). *Mann Whitney U Test. Conclusions: This is the first study to comprehensively assess positive and negative aspects of the acceptability of VE and intrapartum USS techniques and the impact of RA. USS assessment prior to labour is more acceptable than VE both before and after the examinations. RA did ameliorate the negative experience of the more intrusive VE post assessment but had no effect on the pre and post experience scores of USS implying that without RA, USS is preferred. These findings have implications for women in early labour, without RA, or conditions such as vaginismus or genital mutilation where VE is poorly tolerated.
|
2022-07-31T05:00:07.762Z
|
203,217,176 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1742-6596/1303/1/012135",
"MAG": "2971724464",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1742-6596/1303/1/012135"
}
|
The purpose of this paper is to find an optimal coordinating contract on a two-echelon sustainable supply chain composed of a manufacturer and a retailer under carbon tax policy. Taking consumer environmental awareness (CEA) and manufacturer’s abatement investment cost into account, this study compares wholesale price contract, revenue-sharing contract and green cost-sharing contract, and finds that none of them can obtain coordination. Then, “Adjusted” contracts are introduced and proved that only adjusted revenue-sharing contract can coordinate the supply chain. Considering the profit redistribution proposition of the two-part tariff contract, the study introduces combined contracts, which are found capable of obtaining supply chain coordination as well as a win-win outcome.
|
2022-07-31T21:01:29.136Z
|
71,825,276 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1159/000172346",
"MAG": "2041147259",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We present a technical variation on Pier’s laparoscopic appendectomy. It consists of skeletonization of the appendix just by the appendix serosa from the tip to the base. Thereby we avoid the continuo
|
2022-04-30T07:49:37.641Z
|
130,626,686 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/2015JB012340",
"MAG": "2143580013",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
An 11‐parameter, kinematic‐function (KF) model was used to retrieve the approximate geometrical and kinematic characteristics of the fault source of the 1570 Mw 5.8 Ferrara earthquake in the Po Plain, including the double‐couple orientation (strike angle 127 ± 16°, dip 28 ± 7°, and rake 77 ± 16°). These results are compatible with either the outermost thrust fronts of the northern Apennines, which are buried beneath the Po Plain's alluvial deposits, or the blind crustal‐scale thrust. The 1570 event developed to the ENE of the two main shocks on 20 May 2012 (M 6.1) and 29 May 2012 (M 5.9). The three earthquakes had similar kinematics and are found 20–30 km from each other en echelon in the buried chain. Geomorphological and historical evidence exist which suggest the following: (i) the long‐lasting uplift of the buried Apenninic front shifted the central part of the course of the Po River approximately 20 km northward in historical times and (ii) the 1570 earthquake marked the definitive diversion of the final part of the Po River away from Ferrara and the closure of the Po delta 40 km south of its present position.
|
2022-09-02T06:44:32.996Z
|
36,863,018 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/ac4042203",
"MAG": "2319658817",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Mycoplasma bovis (M. bovis) is a major, but often overlooked, pathogen that causes respiratory disease, mastitis, and arthritis in cattle. It has been widespread in China since 2008. In this study, single-stranded DNA (ssDNA) aptamers with high affinity and specificity against the P48 protein of M. bovis were selected using microplates as the matrix. Of nine candidates, aptamer WKB-14 showed the best affinity in an indirect enzyme-linked aptamer assay (ELAA) and good specificity by dot blotting. To the best of our knowledge, this is the first time that an aptamer has been used in a competitive ELAA for the serological detection of M. bovis. The percent inhibition (PI) cutoff value of the indirect competitive ELAA (ic-ELAA) was 40%, assessed using 20 negative sera. In a comparative study of different detection methods, ic-ELAA with dc-ELISA and dot blotting had a higher positive detection rate than the other two commercial indirect ELISA kits.
|
2022-12-15T18:10:04.136Z
|
36,964,558 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/MPH.0b013e318159a582",
"MAG": "2043009697",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Central nervous system (CNS) involvement is rare in acute promyelocytic leukemia (APL). The majority of CNS relapses occur in patients with hyperleukocytosis at presentation, and the optimal management of such patients is still controversial. We describe a 13-year-old boy with APL who developed an isolated CNS relapse after first-line treatment with all-trans retinoic acid and chemotherapy. A second remission was achieved with a regimen consisting of intrathecal chemotherapy, intravenous high-dose cytarabine, and oral 6-mercaptopurine. All-trans retinoic acid was avoided owing to severe complications during initial therapy. The patient remains in molecular remission at 9 months after autologous stem cell transplant. Prognostic factors of CNS relapse in children with APL are needed to define the indications for CNS prophylaxis in this group of patients.
|
2022-09-06T09:23:51.958Z
|
85,322,573 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1071/SB12002",
"MAG": "2046465875",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Abstract. Molecular systematics has clarified the limits of Loganiaceae (Gentianales), the tribal circumscriptions and the phylogenetic relationships within the family. Loganieae includes seven genera; however, generic boundaries remain untested and intergeneric relationships are largely unknown. The chloroplast intron petD and the nuclear ribosomal ETS were sequenced for 37 ingroup accessions, including all genera of Loganieae, to infer generic and infrageneric boundaries and intergeneric relationships within the tribe. Maximum parsimony and Bayesian analyses resolved several strongly supported clades. Mitreola s. str. was placed sister to the rest of Loganieae. The south-western Australian endemic, Mitreola minima B.J.Conn, was placed sister to Mitrasacme, Schizacme and Phyllangium, rendering Mitreola polyphyletic. Mitrasacme, Logania section Logania and L. section Stomandra were each strongly supported as monophyletic, but there was no support for the monophyly of Logania. Geniostoma was paraphyletic with respect to a monophyletic Labordia. It is here recommended that Mitreola minima be afforded generic status and that the three species of Labordia used in the present study be reduced to synonymy of Geniostoma. Additional sampling is needed to clarify the relationship between Logania section Logania and L. section Stomandra and to increase support for intergeneric relationships in Loganieae.
|
2022-12-19T00:13:10.252Z
|
247,209,340 |
{
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"ArXiv": null,
"DOI": "10.1177/23337214221081372",
"MAG": null,
"PubMedCentral": "8891594"
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://journals.sagepub.com/doi/pdf/10.1177/23337214221081372"
}
|
Latinx adults experience a high burden of dementia. Given that modifiable factors drive dementia disparities, engaging Latinxs in Alzheimer’s disease and related dementias (ADRD) education is critical to address dementia burden among this aging population. Yet, no studies have documented the role of the COVID-19 pandemic on dementia education among Latinxs. This study: (1) elucidates the recruitment and retention processes targeting Latinxs for online educational events during the pandemic; (2) describes facilitators/barriers to participation; and (3) offers lessons learned. We developed online dementia-focused workshops (English and Spanish) and employed a cold-calling approach to invite Latinx participants enrolled in clinical studies (N = 209). Bivariate tests assessed demographic and cognitive differences between those who recruiters did (n = 60) and did not (n = 149) successfully engage. Frequency counts assessed participants’ technological access. Only 8/209 attended the online events; all held university degrees, most reported English as their primary language, and none experienced cognitive impairment. Results underscore how educational attainment, cognitive impairment, language preference, and age intersect to shape recruitment in dementia-focused online education. To promote healthy aging and to ameliorate dementia disparities, barriers to online engagement among older Spanish-speaking Latinxs with cognitive impairment and low educational attainment must be addressed.
|
2022-12-29T18:12:25.958Z
|
55,236,435 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18805/IJAR.V0IOF.4568",
"MAG": "2556398301",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Low density lipoproteins (LDL) extracted from hens egg yolk (EY) has been studied over EY based extender for liquid storage of mithun semen with the objective to explore the use of LDL in place of EY. Physio-morphological attributes (PMAs) and mobility and velocity parameters were measured by computer assisted sperm analyser (CASA). Leakage of intracellular enzymes, activity of total antioxidants and lipid peroxidation following liquid storage (5oC) of mithun semen were studied. Fifty ejaculates were collected through transrectal massage method from matured mithun bulls and based on the mass activity and individual motility; the semen samples were splited into good and poor quality and diluted with the tris citrate glycerol (TCG) extender and were splited into three equal aliquots: Group I: Control, EY; Group II and Group III contained 8 and 10% LDL (w/v), respectively. PMAs, intracellular enzymatic leakage and biochemical profiles were evaluated at 5°C following 10hrs incubation. Result revealed a significant (p<0.05) improvement in PMAs, CASA parameters and cholesterol content of spermatozoa as well as reduction in leakage of intracellular enzymes, oxidative stress in Group II than control and other treatment group. It was concluded that addition of 8% LDL holds a clear advantage over EY or 10% LDL in liquid preservation of mithun semen.
|
2022-12-30T18:36:51.739Z
|
89,517,034 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7282/T3PK0J4K",
"MAG": "2498617004",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Flame retardants (FR) such as polybrominated diphenyl ether (PBDE) congener 2,2’,4,4’tetrabromodiphenyl ether (BDE-47) and organophosphate FRs (OPFR) persist in the environment and interact with multiple target receptors involved in energy homeostasis, including estrogen receptors (ERs). Estrogenic EDCs such as bisphenol A (BPA) disrupt homeostatic gene expression in the arcuate nucleus (ARC) of the hypothalamus, which centrally controls energy balance. However, little is known about the effects of FRs, especially OPFR. Therefore, we investigated if exposure to these FR alters adult 17-β estradiol (E2)-regulated gene expression in the ARC. Adult male and female mice were orally dosed daily vehicle (oil), 17αethinyl estradiol (2.5 μg/kg), BDE47 low or high dose (1 mg/kg or 10 mg/kg), and OPFR mixture low or high dose (1 mg/kg or 10 mg/kg of tris (1,3-dichloro-2-propyl) phosphate (TDCPP), triphenyl phosphate (TPP), and tricresyl phosphate (TCP) each) for 28 days. EE2 was used as a positive estrogenic EDC control. ARC mRNA expression, weekly cumulative body weight gain, and uteri weights were measured. In male ARC, FR upregulated GhsR, Insr, Lepr, Cacna1g, -h, -i, Kcnq2,-3,-5, mRNA expression while downregulating Esr1, Cart, and Npy. OPFR increased Agrp and Pomc ARC expression in males. In female ARC, BDE47 suppressed ARC Ghsr and Cart, but augmented Insr and Cacna1g. OPFR also decreased Ghsr, Pomc, Cart, while increasing Insr and Cacna1g in females. Overall, FR more drastically influenced ARC gene expression in males than in females. These results suggest that these FR alter ARC gene expression in a sex-dependent manner in
|
2022-01-27T10:34:33.123Z
|
167,689,608 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/108056997603900307",
"MAG": "1967815245",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
cation. Since I had spent the better part of a decade studying literature, and the last year and a half teaching freshman composition, I didn’t know the first thing about business or administration. Every other day I found myself running to some old veteran in the Business and Technical Writing Division to find out about garnishments, confessions of judgment, or any of a thousand other foreign-sounding concepts. (At first glance, I thought &dquo;3/20, n60&dquo; was a geographical fix.) After
|
2022-02-08T18:50:29.656Z
|
109,995,307 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/SECON.1995.513113",
"MAG": "2111022656",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A large spacecraft such as the planned space station requires a relatively large amount of electrical power for its routine operation. For example, the power required by the space station is expected to be about 300 kW. This high power requirement entails a power system operating at a high voltage. The space station will operate at about 160 V. Such a large voltage in conjunction with the grounding scheme of the solar cell arrays, would make the potential of the space station structure highly negative with respect to the ionospheric plasma. Since the structure of the station is insulated by a 3-/spl mu/m thick coating of Al/sub 2/O/sub 3/ and the plasma shields the potential, the large negative potential drops across the thin insulating layer, creating an intense electric field (/spl sim/5/spl times/10/sup 7/ V/m) in it. This raises the possibility of dielectric breakdown and arcing from the space station structure to the ionospheric plasma. Laboratory simulations of the arcing have shown large arc currents (/spl sim/1500 A) with a rise time of about 0.1 ms and a total duration of about /spl sim/1 ms. Such a large arc current can affect the operation of the power system and generates electromagnetic waves, which cause concerns about electromagnetic interference. In this paper we report the results from a study on the electromagnetic fields generated by the arc. This problem is modeled as the radiation from a monopole antenna having a transient current in a magnetized plasma.
|
2022-02-10T05:34:04.088Z
|
53,971,860 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.16966/2378-7090.242",
"MAG": "2767078429",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://doi.org/10.16966/2378-7090.242"
}
|
Recently, clinical usefulness of using LigaSureTM system with vessel-sealing devices and the ValleylabTM electrode knife (Covidien, USA) for head and neck cancer surgery was widely reported. These devices were used to resection of small hemangioma for 71 and 78 year-old women with small hemangiomas of the lateral surface of the tongue. The resection by LigaSureTM system for the treatment of small tongue hemangioma was bloodless and short-time surgery with no complication.
|
2022-02-11T21:17:49.432Z
|
12,941,567 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/00003226-200011002-00108",
"MAG": "2410827966",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Clinical criteria for the diagnosis of dry eyes are limited; most patients are diagnosed on the basis of subjective responses. This makes assessment of dry eye treatments difficult in clinical practice and research, and additional clinical tests are needed. Morgan et al. reported an increase in corneal temperatures in dry eye patients; measurements were made with (infrared) IR thermography. Presumably the increased temperature is due to the increased blood flow associated with the accompanying inflammation.
|
2022-09-11T08:24:25.856Z
|
62,146,252 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4028/www.scientific.net/KEM.620.516",
"MAG": "2083594187",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Aiming at the problem of image quality degradation due to scenes change rapidly, an image enhancement algorithm based on scene intelligent identification is proposed. The algorithm sharpen the image detail by using Laplace operator. Determines the change image scene according to the gray value, constructs different gray mapping function, and adjusts gray value range of image adaptively to improve the contrast ratio of image enhancement. By using parallel processing, the algorithm has high execution efficiency, so it can meet the real-time processing of HD video. Experimental result shows that the proposed algorithm has satisfying performance in the rapidly change scene.
|
2022-09-07T03:17:34.705Z
|
136,809,442 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.255520",
"MAG": "2050938958",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
New possibilities of photochromic glasses ceramics for integrated and gradient optics have been shown. The ion- exchanged technique for waveguide fabrication was developed. T he waveguides with gradients of refractive index, absorption, and photosensitivity were made. Photoinduced light absorption effects and photosensitive properties of these structures have been studied. Spacing and polarizing selectors of waveguide modes were made.
|
2022-01-27T13:13:17.236Z
|
44,737,415 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/ANA.410050417",
"MAG": "2077502879",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A woman with left atrial myxoma had progressive disturbance of intellectual function, headache, and prominent constitutional symptoms. The absence of stroke is noteworthy. Multiple high‐density lesions with contrast enhancement were seen by CT scan, suggesting metastatic neoplasms, hematomas, or hemorrhagic infarcts. Serial study showed progressive enlargement of the lesions. The only cerebral lesion examined histologically proved to be an organizing hematoma, originating most likely from adjacent small arteries found to be plugged by embolic myxoma.
|
2022-12-14T03:49:13.009Z
|
122,936,571 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/0953-4075/30/24/024",
"MAG": "2080271422",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We have extended and further improved our previous R-matrix with pseudo-states (RMPS) calculation for electron collisions with beryllium (1996 J. Phys. B: At. Mol. Opt. Phys. L769 - 72). Results for transitions from the ground state to the lowest 11 target states with principal quantum number n = 2,3 are presented for incident energies from threshold to 100 eV. In the crucial `intermediate energy range' of 10 - 100 eV, our results are in good agreement with those obtained in the convergent close-coupling (CCC) calculation of Fursa and Bray, whereas significant discrepancies are found with predictions from simpler models. Consequently, a combination of RMPS and CCC predictions in this region, supplemented by our RMPS results in the low-energy resonance regime and further CCC results above 100 eV incident energy are believed to represent the most accurate currently available data for this collision problem.
|
2022-12-20T11:04:15.568Z
|
44,609,559 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1006/jcta.2000.3137",
"MAG": "2085822092",
"PubMedCentral": null
},
"license": "elsevier-specific: oa user license",
"status": "BRONZE",
"url": "https://doi.org/10.1006/jcta.2000.3137"
}
|
We investigate the existence of cyclic relative difference sets with parameters ((qd?1)/(q?1), n, qd?1, qd?2(q?1)/n), q any prime power. One can think of these as “liftings” or “extensions” of the complements of Singer difference sets. When q is odd or d is even, we find that relative difference sets with these parameters exist if and only if n is a divisor of q?1. In case q is even and d is odd, relative difference sets with these parameters exist if and only if n is a divisor of 2(q?1).
|
2022-10-07T14:21:29.824Z
|
209,246,231 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14341/probl11708",
"MAG": "2980033143",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "HYBRID",
"url": "https://www.probl-endojournals.ru/jour/article/download/11708/8586"
}
|
Autoimmune polyglandular syndromes (APS) are the primary defeat of the autoimmune process of 2 peripheral endocrine glands and more, leading, as a rule, to their insufficiency, often combined with various organ-specific non-endocrine autoimmune diseases.
|
2022-07-09T04:22:51.718Z
|
170,288,003 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.11606/ISSN.2447-9012.ESPINOSA.2008.89339",
"MAG": "2228504373",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper investigates the concept of contemplation in the book two of Spinoza ´s Ethics, examining the uses of that term, as much as its precise sense, in the contexts of each one of the three kinds of knowledge proposed by the philosopher. The analysis of these passages indicates that Spinoza uses the term to signify the knowledge of singular things, either in the field of inadequacy (first kind of knowledge) or of adequacy (third kind). The appearances of the term in propositions on the second kind (knowledge of general properties) do not invalidate the hypothesis, because they don´t aim at the object itself of this kind of knowledge, but at a previous condition of it.
|
2022-08-26T14:19:16.184Z
|
19,067,852 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/sim.5833",
"MAG": "2080316714",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc5933533?pdf=render"
}
|
Many countries, including the USA, publish predicted numbers of cancer incidence and death in current and future years for the whole country. These predictions provide important information on the cancer burden for cancer control planners, policymakers and the general public. Based on evidence from several empirical studies, the joinpoint (segmented‐line linear regression) model (JPM) has been adopted by the American Cancer Society to estimate the number of new cancer cases in the USA and in individual states since 2007. Recently, cancer incidence in smaller geographic regions such as counties, and local policy makers are increasingly interested with Federal Information Processing Standard code regions. The natural extension is to directly apply the JPM to county‐level cancer incidence data. The direct application has several drawbacks and its performance has not been evaluated. To address the concerns, we developed a spatial random‐effects JPM for county‐level cancer incidence data. The proposed model was used to predict both cancer incidence rates and counts at the county level. The standard JPM and the proposed method were compared through a validation study. The proposed method outperformed the standard JPM for almost all cancer sites, especially for moderate or rare cancer sites and for counties with small population sizes. As an application, we predicted county‐level prostate cancer incidence rates and counts for the year 2011 in Connecticut. Published 2013. This article is a US Government work and is in the public domain in the USA.
|
2022-09-11T05:29:12.561Z
|
94,324,583 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1139/V81-257",
"MAG": "1987598777",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
When five- and six-membered cyclic β-dicarbonyl compounds having an acetyl group on the 2-position were irradiated in methanol in the presence of TiCl4, a coupling reaction between the acetyl carbonyl atom and the α-carbon atom of the methanol took place, giving γ-ketoaldehydes or dihydrofurans as the main product.
|
2022-09-13T16:35:25.390Z
|
238,413,570 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TENSYMP52854.2021.9550812",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Diabetic Foot Ulcer is a very common problem that faces diabetic patients with almost 15 percent of these patients developing a foot ulcer at least once in their life. Diabetic patients tend to suffer from numbness and loss of sensation in their feet making it hard for them to self-detect the ulcer therefore an early detection method is needed. The approach conducted in this paper uses a 2-dimentional image as an input and using convolutional neural networks to analyze the images. The system will classify the input images into two states, no ulcer or the ulcer is present and in this case the location of the ulcer will be marked on the image. The system achieved an F1- score of 81.3% with an improvement of more than 7% from the F1-score achieved in the Diabetic Foot Ulcer Challenge 2020.
|
2022-09-30T00:20:11.427Z
|
34,734,067 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/00007632-198311000-00006",
"MAG": "2003565873",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The correction of scoliosis induced by pure lumbar flexion was compared with the correction with the so-called Boston Thoracic Brace. Ten patients with idiopathic scoliosis were studied. There were 11 primary curves (31 ± 6°) (mainly thoracic) and four secondary curves (22 ± 1°). Pure lumbar flexion reduced the primary curves by 6 ± 2° and the secondary curves by 8 ± 3°. The brace reduced the curves by 16 ±. 6° and 14'± 5°, respectively. Lumbar flexion per se produces a correction of the scoliosis of the same degree as the Milwaukee brace. Our results emphasize the importance of reduction of the lumbar lordosis in the conservative treatment of scoliosis.
|
2022-12-16T01:49:07.613Z
|
5,614,358 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1558-5646.2007.00068.x",
"MAG": "2116181021",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1558-5646.2007.00068.x"
}
|
Abstract Theory predicts that biogeographic factors should play a central role in promoting population divergence and speciation. Previous empirical studies into biogeography and diversification have been relatively restricted in terms of the geographical area, phylogenetic scope, and the range of biogeographic factors considered. Here we present a global analysis of allopatric phenotypic divergence (measured as subspecies richness) across more than 9600 bird species. The main aim of this study was to examine the extent to which biogeographical factors can explain patterns of phenotypic divergence. Analysis of the taxonomic distribution of subspecies among species suggests that subspecies formation and extinction have occurred at a considerably faster rate than has species formation. However, the observed distribution departs from the expectation under a random birth–death model of diversification. Across 19 phylogenetic trees, we find no significant linear relationship between species age and subspecies richness, implying that species age is a poor predictor of subspecies richness. Both subspecies richness and subspecies diversification rate are found to exhibit low phylogenetic signal, meaning that closely related species do not tend to possess similar numbers of subspecies. As predicted by theory, high subspecies richness was associated with large breeding range size, island dwelling, inhabitation of montane regions, habitat heterogeneity, and low latitude. Of these factors, breeding range size was the variable that explained the most variation. Unravelling whether species that have invaded previously glacial areas have more or fewer subspecies than expected proves to be complicated due to a covariation between the postglacial colonization, latitude, geographic range size, and subspecies richness. However, the effect of postglacial colonization on subspecies richness appears to be small. Mapping the distribution of species' subspecies richness globally reveals geographical patterns that correspond to many of the predictions of the statistical models, but may also reflect geographical variation in taxonomic practice. Overall, we demonstrate that biogeographic models can explain about 30% of the global variation in subspecies richness in birds.
|
2022-12-17T23:26:05.109Z
|
98,364,140 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/JCTB.2600",
"MAG": "2141914586",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
BACKGROUND: In the removal of pharmaceuticals present in aquatic systems by membrane processes, some important issues must be explored in order to obtain a better knowledge of the global process. Among these issues, a better understanding of the influences of the operating parameters on the membrane flux, an analysis of membrane resistances and fouling, and determination of the removal of specific substances, must be studied.
RESULTS: Four selected pharmaceuticals (amoxicillin, naproxen, metoprolol and phenacetin) were subjected to ultrafiltration (UF) and nanofiltration (NF) processes for their removal from several water matrices. The determined permeate fluxes at the steady state were affected by the main operating conditions: molecular weight cut-off (MWCO) of the membrane, transmembrane pressure TMP, cross-flow velocity and temperature. The retention coefficients with the UF membranes followed the sequence naproxen > metoprolol > amoxicillin > phenacetin, and with the NF membranes, followed the trend: amoxicillin > naproxen > metoprolol > phenacetin, due to the role of other mechanisms such as size exclusion and electrostatic repulsion. In the case of the selected water matrices, the retention coefficient was referred to some quality parameters (total organic carbon, chemical oxygen demand and absorbance at 254 nm), leading to moderate (UF) or high (NF) removals of the organic matter content.
CONCLUSIONS: The NF CK membrane achieved the highest retention of these pharmaceuticals (excepting phenacetin), and provided retentions for quality parameters around 80% in the four water systems tested. Copyright © 2011 Society of Chemical Industry
|
2022-12-20T10:59:40.736Z
|
188,097,253 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17058/REA.V26I3.11754",
"MAG": "2900959137",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Ao compreender a docência como uma matriz de experiência, esquema teórico criado por Michel Foucault, este artigo problematiza os modos de constituir-se professor/a em uma sociedade inclusiva. A partir das investigações desenvolvidas no interior dos grupos de pesquisa Gipedi e Gepi, que têm como inspiração teórica os Estudos Foucaultianos, o argumento central é de que os três eixos que compõem a matriz de experiência (saber-poder-ética) são importantes para compreendermos a constituição da docência contemporânea e a subjetivação do sujeito professor, ambos marcados pelo imperativo da inclusão. A análise de narrativas de estudantes de Pedagogia, participantes de um programa de iniciação à docência, identificou a constituição de uma docência virtuosa, colocada em operação através das técnicas do comprometimento, da tática e da intervenção. A proposta é contribuir para pensar a formação de professores, especialmente a dimensão ética que atravessa o campo da docência.
Palavras-chave: Docência. Matriz de experiência. Sociedade inclusiva. Formação de professores.
|
2022-02-08T10:24:45.744Z
|
162,253,093 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1515/iber.1989.1989.30.63",
"MAG": "2048566380",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Aproximarse al estudio del espafiol rural hablado en Uruguay supone roturar un campo totalmente virgen. En efecto, si bien existen algunos informes muy generales sobre la situacion lingüistica del pals (dejando de lado una zona relativamente mejor estudiada: Montevideo y su zona de influencia, o, desde otro ängulo, Montevideo dentro de la asi llamada zona "rioplatense". V. Elizaincin & Behares 1981) ninguno de ellos puede tomarse como fuente de information medianamente fiel acerca de la situacion real actual. Las razones que explican este estado de cosas trascienden los limites y objetivos del presente trabajo, por lo que no es del caso detenerse en estas circunstancias. La debilidad e inconsistencia de muchas de las fuentes utilizadas por los diferentes autores sobre el tema quedan claras en el trabajo panorämico de A. Rossell (1978). Dado este estado general de la investigation, este estudio no puede plantearse mas que como una aproximacion y aun asi necesitamos establecer ciertas delimitaciones previas muy importantes. La intention inicial ha sido la de aportar datos para el conocimiento del "espanol rural"; pero el concepto mismo merece una breve discusion. Obviamente el "espanol rural" seria aquel utilizado por la poblacion rural del pals, modalidad que, eventualmente, podria ser contrastada a un "espanol urbano". Tal oposicion, sin embargo, no surge claramente en los datos que poseemos. Por un lado, el Uruguay, a pesar de poseer una economia de cuno netamente agrario, es un pais esencialmente urbano. Mas de la mitad de la poblacion vive en centros urbanos y, fundamentalmente, en la capital, Montevideo. La migration interna hacia las ciudades, fenomeno comun a toda Latinoamerica, es especialmente notoria en Uruguay, pequeno pais de c. 3 millones de habitantes. De esta manera, las ciudades, y especialmente Montevideo, confi-
|
2022-02-08T21:50:56.762Z
|
244,343,742 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31254/jahm.2020.6201",
"MAG": "3204351189",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.31254/jahm.2020.6201"
}
|
Viral pneumonia outbreak in Wuhan, China, in 2019 was observed and a novel coronavirus was identified as the cause of this outbreak. COVID-19 was the official term given by the World Health Organization and announced this on February 11, 2020 publicly. Corona virus spreads through person to person contact. The novel corona virus has taken a few months to sweep the globe, there are certain questions that are impossible to fathom as the disease rages. As the vaccine for Covid-19 is not yet discovered, the virus is being controlled from spreading worldwide through numerous strategies. Therefore, noticing the virulence of this virus several preventive measures have been taken at a global level to protect the human race. One of the effective measures in controlling the spread of respiratory disease epidemics is maintaining social distance and, therefore, can be used as a way to reduce its spread. Improving the immune power of a person is another crucial measure adopted to obviate its spread. AYUSH system of medicine is performing a central role in the contribution of meliorating the immune system of a person. Variety of herbal combinations have proven to perform the same function. The very first and easy way to boost the immunity and kill the virus, is to drink warm water throughout the day. It is further also advised to take steam once a day. 30 minutes of daily practice of Yogasana, Pranayama and meditation contributes in boosting immunity. Also using Dhaniya, Haldi, Jeera and Lahsun in cooking helps. It is also advised to use Half teaspoon Haldi with 150 ml of Hot milk, once or twice a day. Consuming Chyavanprash 10 mg in the morning is equally helpful.
|
2022-06-27T21:05:30.692Z
|
51,822,927 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVB.69.241403",
"MAG": "2326607255",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This work reports Raman spectroscopy measurements from single wall carbon nanotubes (SWNTs) addressing the nature of the $G$-band resonance Raman spectra. Experimental results on different samples are presented, i.e., aligned and misaligned SWNT samples, as well as isolated and bundled SWNTs. It is shown that the Raman spectra from nondefective SWNTs, both isolated and bundled, are composed of strong first-order single resonance Raman features. Defective materials, however, are found to exhibit lower intensity spectra with contributions from both single resonance and defect-induced double resonance features.
|
2022-12-12T23:34:58.343Z
|
41,974,053 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/JAMA.1962.03050230001001",
"MAG": "2045402788",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper supports the hypothesis that the concomitance of hyperparathyroidism and pancreatitis is more than coincidental, and that there is some etiologic relationship between the 2 conditions. Study of a patient described in detail in this report and of 26 other patients mentioned in the literature suggests that some cases of pancreatitis are secondary to hyperparathyroidism. The importance of pancreatitis as a diagnostic clue to hyperparathyroidism is emphasized by the increasing number of cases that are being found. The presence of hyperparathyroidism may be obscured by having an otherwise elevated serum calcium concentration reduced to normal by acute pancreatitis. Conversely, when the serum calcium concentration is paradoxically high, or the serum phosphate concentration is low in the presence of acute pancreatitis, appropriate studies to exclude hyperparathyroidism should be performed.
|
2022-12-18T09:21:58.223Z
|
249,887,004 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/13814788.2022.2085683",
"MAG": null,
"PubMedCentral": "9225685"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/13814788.2022.2085683?needAccess=true"
}
|
Abstract Background Fibromyalgia is a functional syndrome. Despite recent findings, there is still considerable uncertainty about its diagnostic process. Objectives This study aimed to explore patients’ experiences with fibromyalgia during the diagnostic process in primary health care. Moreover, we tried to determine how diagnostic consultation could be improved. Methods This study is based on data from patients with fibromyalgia in a primary health care study conducted in Nokia, Finland. Patients with fibromyalgia were identified from electronic medical records. Focus-group participants with fibromyalgia diagnoses were selected using a purposive sampling method to gather a maximum variation sample. Qualitative thematic analysis was used for the coded data from four focus-group discussions in 2018. A description of the coding tree was provided and researchers organised the codes. Finally, all researchers identified themes from the data. Results The main unifying entities were the uncertainty and contradictions fibromyalgia patients faced on several occasions. Physicians sometimes offered other diagnoses – like depression – as an explanation for the symptoms, or used repetitive tests to eliminate other possible diagnoses. Furthermore, patients expressed their wishes for a holistic, empathetic, and up-to-date approach to their symptoms. Conclusion In our interviews, a good doctor-patient relationship and continuity of care were necessary, as were the physician’s attitude and knowledge of fibromyalgia. Our findings also suggest avoiding repeated or unnecessary rule-out tests and the overdiagnosis of psychiatric disorders is necessary.
|
2022-12-20T21:29:04.656Z
|
240,262,376 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.37544/0720-5953-2021-11-12-36",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Positioniersysteme in der Halbleiterfertigung und der hochgenauen Messtechnik müssen immer präziser bewegen, um die voranschreitende Miniaturisierung zu bewältigen. Für neue Fertigungsverfahren werden immer größere vertikale Stellbereiche gefordert. Dafür hat das IMMS bereits einen 6D-Direktantrieb entwickelt, der Objekte in einem Verfahrbereich von 100 mm Durchmesser in einem Hebe- beziehungsweise Senkbereich von 10 mm frei im Raum nanometergenau und aktiv geregelt positioniert. Die Hubmodule wurden nun weiterentwickelt, um das System aufgrund des 75 % geringeren Wärmeeintrags für den Einsatz in der Fertigung und Messtechnik zu optimieren. Der parallel erarbeitete Design-Flow für große Bewegungsbereiche ist die Basis für noch effizientere anwendungsspezifische Entwicklungen.
|
2022-02-07T20:18:38.359Z
|
251,166,711 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17582/journal.pjz/20210818080851",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://researcherslinks.com/uploads/articles/1659007692PJZ_MH20220211070241-R2_Guo et al.pdf"
}
|
This article presents a comparative characteristic of cows’ dairy productivity in the context of three lines: Reflection Sovereign and Wis Burke Ideal and Osborndale Ivanhoe in the conditions of the breeding farm of Kostanay region. Studies on lactating cows have shown that cows of the Wis Burke Ideal line have an advantage in milk productivity. Furthermore, that the highest productivity was noted in cows of the Wis Burke Ideal line – 14793.02, which is 3894.44 and 3523.52 kg higher than in the peers of the Reflection Sovereign and Osborndale Ivanhoe lines. Since the research farm specializes in breeding Holstein breed it is necessary to adhere to the standard of the breed in all genetic, constitutional, exterior and productive parameters. To fully realize the genetic potential of the breed it is necessary: to select for artificial insemination bulls from the line whose offspring are most productive and physiologically more adapted to the climatic, technological and forage conditions of the farm. When selecting, special attention should be paid to the strength of the hoofed horn and the duration of commercial use. For the given purposes it is recommended to use such bulls of the Wis Burke Ideal line whose average milk productivity exceeds that of their coevals and the breed standard and simultaneously allows to keep productive longevity and reproductive ability. The results obtained in the course of research indicate the influence of such genotypic factor as ‘lineage’ on the productive longevity of Holstein cows. The most longevity and highly productive were the cows of line Wis Burke Ideal. The results obtained during the researches testify to the influence of such genotypical factor as “lineage” on the productive longevity of Holstein cows. The most long-lived and highly productive cows were those of the Wis Burke Ideal line. The prospects for breeding dairy cows also lie in the fact that they have practically shown high milk productivity at the end of three lactations.
|
2022-08-18T18:52:31.347Z
|
108,639,006 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.361224",
"MAG": "1987829865",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ICP plasma etching is gaining widespread acceptance as an enabling micromachining technology for advanced MEMS fabrication. Whereas this technology has shown a capability of delivering multiple novel applications for R and D, its acceptance by industry for high volume production has been limited. This acceptance into production will only occur when the plasma etching equipment with this technology offers the device performance, throughput, reliability, and uptime criteria required by a production facility. The design of the plasma etcher using this technology and the process capability it consequently delivers, has significant implications in making this a reality. Alcatel has been supplying such a technology to this MEMS industry for over 5 years and in the interim has evolved its product and process to make this technology production worthy. Alcatel's next generation etcher, the Alcatel 601E, offers multiple advantages to MEMS manufacturers in realizing their production goals.
|
2022-09-02T18:28:01.648Z
|
31,678,978 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/AJMG.1325",
"MAG": "2032368788",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We have previously reported cosegregation of bipolar affective disorder and Darier disease, a dominant skin disorder with a neuropsychiatric component. The gene for Darier disease was mapped to chromosome 12q23-q24.1 and linkage studies have subsequently implicated this region as harboring a susceptibility gene for bipolar affective disorder. We have genomically characterized the human homologue of murine Cux-2, a neuronal-specific transcription factor potentially involved in the regulation of neural cell adhesion molecule expression that maps to this region. Also, in a panel of 15 unrelated bipolar patients from multiply affected families showing increased allele sharing at markers in the 12q23-q24.1 region, we performed mutational screening of the CUX2 coding sequence, and 5' untranslated region (5' UTR). Resulting sequence were analyzed in a large sample of bipolar patients (n = 218) and control subjects (n = 218). No evidence was found for the involvement of variants within the CUX2 coding, or 5' UTR sequence in producing susceptibility to bipolar disorder.
|
2022-09-09T01:00:57.923Z
|
44,941,651 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1439-0442.2006.00805.X",
"MAG": "2089788428",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This study tested and compared the anti-proliferative and proliferative activities of two anti-oestrogens and three anti-progestins on four separate mouse model systems: young intact and adult ovariectomized (OV-X) females, and young intact and adult castrated males. Pure steroidal anti-oestrogen ICI 182,780 (ICI) decreased mammary and uterine growth stimulated by endogenous hormones in young intact females and by exogenous hormones [progesterone (Prog), 17beta-oestradiol (E) or E plus Prog] in both young intact and adult ovariectomized (OV-X) females. Non-steroidal anti-oestrogen EM-800 (EM), on the other hand, had no effect on mammary and uterine growth stimulated by endogenous hormones in young intact females and in adult OV-X females. Uterine growth was even stimulated by EM alone, and a combination of EM plus Prog not only stimulated uterine growth but also mammary growth (an oestrogenic agonistic activity). However, EM showed anti-oestrogenic activities in both mammary and uterine tissues in females treated with E or E plus Prog. In males, ICI and EM decreased mammary growth stimulated by exogenous hormones (E or E plus Prog) in both young intact and adult castrated animals. In young intact, but not in adult castrated males, ICI increased seminal vesicle growth affected by both endogenous and exogenous (Prog, E or E plus Prog) hormones. EM, on the other hand, decreased seminal vesicle weights in E or E plus Prog and increased its weights in Prog-treated young intact males. Thus, under certain conditions EM possess mixed agonist and antagonist activity in the mammary gland, uterus and seminal vesicles. Norethindrone acetate (NA)-stimulated mammary growth was decreased by anti-progestins onapristone (ON), RU 46556 (RU), and RU 38486 (MI) by 34-59% in females and by 35-93% in males. Uterine weights of NA-treated females were decreased by ON and RU by 29-55% but not by MI. In NA-treated young intact males, seminal vesicle weights were stimulated by RU (by 63%) and not affected by ON and MI. In NA-treated adult castrated males, seminal vesicle weights were decreased by ON, increased by RU and not affected by MI. The results obtained in these and our earlier studies show clearly that mouse four-model systems could serve as in vivo tool for the detection of steroid hormone agonist and antagonist activities of natural and man-made chemicals.
|
2022-09-23T16:59:18.968Z
|
20,791,066 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/0886260517707311",
"MAG": "2612517349",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc5770208?pdf=render"
}
|
Despite efforts to prevent physical teen dating violence, it remains a major public health issue with multiple negative consequences. This study aims to investigate gender differences in the relationships between exposure to interparental violence (mother-to-father violence, father-to-mother violence), acceptance of dating violence (perpetrated by boys, perpetrated by girls), and self-efficacy to disclose teen dating violence. Data were drawn from Waves 1 and 2 of the Quebec Youth Romantic Relationships Project, conducted with a representative sample of Quebec high school students. Analyses were conducted on a subsample of 2,564 teenagers who had been in a dating relationship in the past 6 months (63.8% girls, mean age of 15.3 years). Path analyses were conducted to investigate the links among exposure to interparental violence, acceptance of violence, self-efficacy to disclose teen dating violence (measured at Wave 1), and physical teen dating violence (measured at Wave 2). General exposure to interparental violence was linked, through acceptance of girl-perpetrated violence, to victimization among both genders and to girls’ perpetration of physical teen dating violence. No significant difference was identified in the impact of the gender of the perpetrating parent when considering exposure to interparental violence. Self-efficacy to disclose personal experiences of violence was not linked to exposure to interparental violence or to experiences of physical teen dating violence. The findings support the intergenerational transmission of violence. Moreover, the findings underline the importance of targeting acceptance of violence, especially girl-perpetrated violence, in prevention programs and of intervening with children and adolescents who have witnessed interparental violence.
|
2022-11-13T16:52:00.601Z
|
110,791,427 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/IET-GTD:20070075",
"MAG": "2058753314",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Voltage stability is a challenging problem for independent system operators because of less regulation in power flow patterns and more intensive use of available transmission facilities in deregulated power systems. An equitable and effective scheme for rescheduling pool generation and adjusting contract transactions is proposed in order to ensure adequate voltage stability margin (VSM). A linear optimisation methodology with the objective of minimising the social benefit loss because of generation rescheduling and transaction curtailment is formulated with consideration of the static functional operating constraints and VSM requirements with respect to normal condition and contingencies, and then solved by a linear programming technique. Since the pattern of load increase is difficult to be predicted in new market environment, the system load-ability of the locally closest bifurcation is computed and used as the VSM in the proposed method. The effectiveness of the proposed method has been verified using a modified 39-bus New England test system. A study on the effects of post-contingency corrective capability of the system on social benefit loss and voltage stability performance is also presented.
|
2022-11-21T18:24:54.761Z
|
83,933,538 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1071/EA98017",
"MAG": "1861827646",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Grazing management decisions by beef cattle and sheep producers in south-eastern Australia have tended to be influenced more by the needs of livestock, often with little consideration given to the possible short- or long-term production impacts that the duration or intensity of grazing may have on pastures. This is partially due to inadequate knowledge of these impacts on some pasture types. Grazing decisions relating principally to livestock tend to be based on a subjective appraisal of liveweight change and pasture assessments often with inadequate understanding of critical pasture characteristics influencing livestock production or the ability to assess these characteristics. PROGRAZE is an extension package developed to assist beef cattle and sheep producers improve the quality of grazing management decision making so they more efficiently and effectively achieve their production and market targets for livestock and livestock products while maintaining or improving the productivity and sustainability of their pastures. To measure knowledge change, PROGRAZE participants were surveyed before they commenced the course and again at its conclusion. To measure on-farm adoption of the skills and knowledge contained within PROGRAZE, participants were again surveyed about 12 months after completing the course. Five focus groups were conducted as a means of obtaining direct feedback from a range of participants on issues not adequately addressed through the surveys. The surveys showed the most significant area in knowledge change by participants was associated with pasture quality and the influence of pasture characteristics on pasture intake and livestock prodution. There was strong evidence of practice change by participants particularly, grazing decisions associated with pasture management. When asked whether participation in PROGRAZE had resulted in increased financial returns from their grazing enterprise, 89% replied it had and 91% indicated participation would lead to more sustainable pastures. The overall response to PROGRAZE was positive with 59% of those producers who replied to the survey indicating it exceeded or completely met their expectations and another 36% stating that it had mostly met expectations. Ninety-nine percent of respondents indicated that they would recommend PROGRAZE to fellow producers.
|
2022-12-20T16:59:01.971Z
|
196,641,079 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1089/GTMB.2017.0029",
"MAG": "2749553700",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Aim: The genetic variation in the CD14 rs2569190 promoter region contributes to the susceptibility of developing periodontitis. Since, CD14 gene polymorphism studies among various ethnic populations have produced conflicting results, the present study was designed to unearth the association between the CD14 rs2569190 gene polymorphism and generalized chronic periodontitis (GCP) in a South Indian population of Tamil ethnicity. Methods: Polymorphisms in the CD14 rs2569190 promoter region were analyzed in 96 subjects who were periodontally healthy and 96 patients with GCP. DNA extracted from peripheral venous blood was genotyped by polymerase chain reaction–restriction fragment length polymorphism analysis. One-way analysis of variance, Chi-square testing, and logistic regression analysis were used to test association between GCP and the CD14 rs2569190 single nucleotide polymorphism (SNP). Results: The distribution of the CD14 rs2569190 genotypes and allele frequencies showed significant differences between ...
|
2022-12-24T17:28:03.755Z
|
26,592,559 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1044/1092-4388(2002/094)",
"MAG": "2117126949",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
}
|
This study tested the effect of a method of facilitating prelinguistic communication on parents' responsivity and children's communication and productive language development. The method involved Responsivity education for the parents and Prelinguistic Milieu Teaching for the children (RPMT). Thirty-nine prelinguistic toddlers with intellectual disabilities and their primary caregivers participated in this study. Parent-child pairs were randomly assigned to either the RPMT group or a control group. Communication and language were assessed at study entry and 6, 9, and 12 months later. RPMT facilitated parental responsivity in the posttreatment period. The effect of RPMT on growth rate of child-initiated comments (i.e., the most common type of initiating joint attention) varied by pretreatment measures of that variable. The effect of RPMT on growth rate of child-initiated requests (i.e., the most common type of initiating behavior regulation) varied by presence or absence of Down syndrome. Finally, the effect of RPMT on growth of productive language varied by pretreatment frequency of canonical vocal communication. Recommended alterations in PMT and implications for defining which nonspeaking children are appropriate for prelinguistic goals and treatment were discussed.
|
2022-12-28T18:30:17.367Z
|