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226,493,091 |
{
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"DOI": "10.38055/fs020204",
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"license": "CCBYNCND",
"status": "GOLD",
"url": "https://www.fashionstudies.ca/s/Whos_In_And_Whos_Out_In_Fashion_Studies_Jaclyn_Marcus_Fashion_Studies-jrxy.pdf"
}
|
Despite its relatively recent growth, the field of fashion studies is already known for its many transformations. This year’s College Art Association of America (CAA) Annual Conference featured an exciting new panel on the interdisciplinary nature of dress, entitled Who’s In and Who’s Out of Fashion (Studies)? Chaired by Sarah Scaturro, chief conservator at the Cleveland Museum of Art, and Ann Tartsinis, doctoral student at Stanford University’s Department of Art & Art History, the session addressed the question “Is there a correct or wrong way to do fashion studies?” and aimed to explore what is traditionally defined as “fashion studies” within the discipline. This panel review includes an introduction to the development of the field of fashion and dress, an overview of the topics and case studies presented during the session, and a question and answer session with the Co-Chairs of the panel.
|
2022-01-27T13:28:02.326Z
|
10,438,321 |
{
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"ArXiv": null,
"DOI": "10.1109/icc.2011.5963375",
"MAG": "2105302622",
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|
This paper is focused on a detailed coverage and performance analysis of wireless metropolitan area networks based on the IEEE 802.16 standard, which is the basis of WiMAX technology. A coverage study and performance evaluation of a mobile WiMAX system in an urban and suburban environment with the help of a software simulation tool is presented. All the required parameters are given to the program focusing only in suitable propagation models e.g. ITU-R 525/526, or COST231-HATA. The total coverage of the area was 67% from which 52% provides QAM modulation offering higher data rates to the users. Very promising results were also extracted, when utilizing multiple antennas. It is also found that in a 4 2 system the average received power at the limits of each cell is enhanced about 6.1 dB in comparison with the SISO case.
|
2022-02-13T06:25:05.073Z
|
163,815,608 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0009840X16000354",
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"license": null,
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}
|
Diocletian (R.), Constantine (M. Walraff) and Theodosius I (M. Escribano Paño). M. contributes a chapter on anti-Jewish legislation, S. Ronchey covers the assassination of Hypatia; G. Zecchini studies the fifth-century papal letter on the Lupercalia and A. Pellizzari looks at the still under-utilised Consultationes Zacchei et Apollonii for what it tells us about converting the pagan elite. M. Mazza and R. Lizzi Testa contribute the most broadly focused chapters, dealing with the problem of defining and studying intolerance in Late Antiquity and the historiographic context of the topic, respectively. But all the contributions show how much the ground has shifted since the day when scholars could assume, with Gibbon, that intolerance was an inevitable product of an inherent Christian trait. One shift is an appreciation of how much focusing on Constantine’s conversion has led to an artificial division into preand post-Constantinian eras. Mazza rightly observes that the new concern for religious conformity actually began in the mid-third century, and R.’s study of Diocletian’s law against the Manichees shows that Christians were not the only ones to suffer. Regarding Constantine himself, Wallraff points to continuities (as well as inconsistencies) in the emperor’s policies that are better appreciated once the arbitrary date of 312 is discarded. Another shift has been greater appreciation for contingency, as well as factors that have nothing to do with religion. Hypatia has long been cast as collateral damage from a power struggle between Bishop Cyril and the prefect Orestes, but Ronchey broadens the picture to include Cyril’s pogrom against Alexandria’s Jews and takes note of the difficulty of distinguishing between the now-established spheres of ‘Church’ and ‘State’. Economic interests (control of Egypt’s grain fleet) also played an important role. Economic factors, as well as often-ignored tensions between the leadership in Jerusalem and diaspora Jews, also figure in M.’s analysis of Julian’s plan to rebuild the Temple in Jerusalem. But the topic calling for the greatest amount of nuance is the term ‘intolerance’ itself. Nineteenth-century experts already pointed out that the term did not apply to antiquity, but that caveat did little to prevent others from continuing to write about ‘intolerance’. Here, Zecchini argues that the relevant distinction should be between ‘internal’ and ‘external’, which would eliminate attacks aimed at fellow Christians, and Lizzi Testa gives consideration to using ‘inclusive’ and ‘exclusive’ instead. Current debates over intolerance in ‘political Islam’ undoubtedly have helped spur this new interest in the topic in antiquity. The nuanced treatment in this book should, in its turn, serve as a caution against repeating the same mistakes when studying our own problems.
|
2022-02-08T20:45:26.205Z
|
251,023,445 |
{
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"ArXiv": null,
"DOI": "10.1180/minmag.1975.040.312.12",
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|
Fantale (Gibson, I972) and Ma'Alalta (Barberi et al., I975) the rocks richest in the residual elements are largely post-caldera flows. We suggest that the high C1 and F, characteristic of peralkaline magmas, is instrumental in making elements such as Zr, Nb, Y, Ta, Hf, U, and Th particularly incompatible by forming large complexes with them. This inhibits the substitution of these elements in the crystallizing phases. C1 and F must also reduce the viscosity of a silicate melt and facilitate more rapid and efficient fractional crystallization. Parental halogen-rich alkaline basaltic liquids might be produced by the partial melting of mantle containing a halogen-rich phase such as Ti-phlogopite or K-richterite. We stress that laboratory and field investigations clearly indicate that a halogenbearing vapour phase can seriously modify the composition of some peralkaline silicic and trachytic magmas, particularly those of more extreme compositions but these effects are not yet proven in the earlier stages of the genesis of these rocks, stages that appear to have been dominated by fractional crystallization.
|
2022-07-26T02:03:33.898Z
|
3,254,782 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmj.299.6705.976",
"MAG": "2094441684",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1837796"
}
|
Allison and Professor Hemingway. Now that we have had nearly two years' experience in manipulating digital radiographs and interpreting them on television screens our naive enthusiasm has become well tempered by experience. The advent of the reusable recording medium used in conjunction with conventional x ray equipment has transformed the scene, compared with the forms of apparatus for digital image acquisition that were being mooted six to eight years ago. As yet, technology for image storage, transmission, and recall has not reached the stage at which it can be used for everyday practice in a busy department. Implementation will for technical reasons need to be phased; this is now generally agreed by all experienced workers in this field in both the United States and Europe. We would dispute that we are overcautious, and we remain determined enthusiasts for Picture Archiving and Communications Systems and all that it implies, but we recognise that if for no other reason than our responsibility to the rest of our hospital prudence must not be overwhelmed by naive enthusiasm or other considerations.
|
2022-10-07T00:34:14.368Z
|
168,545,375 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.17485/IJST/2016/V9I34/91943",
"MAG": "2525112214",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objectives: Electronic government is the way the Government works and tries to get better interactions with people and businesses with better access, connectivity, providing better systems and services. Methods/Analysis: The research under taken utilizes quantitative method of data collection for key data. In this research, the population is the citizens in Iran and the unit of analysis is the citizens who worked in some organization in Iran. Data is analyzed by SPSS software (Multiple Regression Analysis). 250 questionnaires were randomly distributed to the society. The questionnaire papers are assigned was given in 5 main cities of Iran, which was Tehran, Isfahan, Shiraz, Tabriz, Mashhad. 118 questionnaire papers were removed; these are those who do not complete the questionnaires properly and completely. Finally, 132 questionnaire papers were collected properly. Findings: According to the findings from this research, the government must emphasize the social issue about how to socialize the service in e-government. Government should be proactive in building the awareness of citizen rather than concentrating on the technical issue because without the awareness and adoption of citizens, the technology used is just a waste of budget. The nature of the globalization process affects countries in order to reduce costs and increase revenue per advent of electronic government. Results are mixed indirect rather than have the same meaning as compared with direct outputs. This research can help governments collect data about factors which have an effect on Iran citizen’s intention to use electronic government services. It will help the government to find out the most important areas that need to be considered. Finally, the most important outcome expected from this study is to increase citizens’ acceptance of Electronic government in the future. Novelty/Improvement: Identify the most important factors that have an effect on citizens of Iran intention to make use of electronic government service.
|
2022-09-03T19:36:57.025Z
|
93,081,030 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31258/JNAT.11.2.129-134",
"MAG": "1583281124",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The demand for petroleum has increased recently due to the increase of world population, industries andtransportation. Biodiesel (fatty acids methyl esters) has become attractive because of high price of petroleum,limited recourses of crude oil, and environmental concerns. Most biodiesel is produced by transesterification oftriglycerides of refined/edible type oils using methanol and homogeneous catalyst such NaOH and KOH. The useof heterogeneous calcined CaCO3 catalyst, has advantages such as the ease of phase separation betweencatalyst and biodiesel. This paper presents factors affecting the synthesis of biodiesel from crude palm using thecalcined CaCO3 catalyst . The synthesis is carried out by two steps, the acid-catalyzed pre-esterification of free-fatty acid and followed by base-catalyzed transesterification of triglycerides. A study of optimizing the reactioncondition of the esterification followed by transesterification of crude palm oil (CPO) is performed to obtainmaximum production of biodiesel. Under conditions of catalyst calcination temperature of 9000C, reactor time of1.5 hours, catalyst dosage of 1,5%, reaction temperature of 700C and methanol/oil molar ratio of 9 : 1, the oilconversion is 74,6%. The as-synthesized biodiesel meets the requirements of Indonesian National Standard (SNI)for biodiesel.
|
2022-11-23T15:04:33.945Z
|
17,522,504 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IIH-MSP.2012.99",
"MAG": "2051797950",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Active and automatic camera tampering detection is more and more important, especially for wide area surveillance systems with large amount of video cameras installed. Generally, a camera functions for video recording and lacks the ability to detect whether tampering has occurred. Most tampering solutions are passive, as evidenced by many surveillance systems frequently left unattended. Tampering detection of real-time automated cameras is thus of priority concern important for timely operator warning. This work describes a novel algorithm for camera tamper detection scheme. Developed for video surveillance and security applications, the pro-posed approach identifies camera tampering by detecting large edge differences and grayscale histogram comparisons between current and previous frames. The optimized algorithm is implemented on PC and TI DAVINCI DM6437 DSP as well. Extensive experiments were performed. Experimental results indicate that the proposed approach can detect various tampering cases. The overall recognition performance was 94%.
|
2022-12-20T19:36:28.085Z
|
227,054,882 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.9771/AA.V0I49.21323",
"MAG": "2076888292",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper presents research about the carnival Cucumbis. These groups had reached their greatest notoriety in the second half of the 1880s, appearing more and more in the newspapers and conquering their space in the streets during the days of carnival. They were recognized as "Africans" by the journalists and other contemporaneous observers: with their "African dances", "African instruments", and "African costumes" parading through the streets. The main objective here is to try to understand the possible meanings behind the act of creating, preserving, and changing one festive action that has the African past as an essential element to the making of identity for their members. This African identity was strengthened precisely while the struggle for the abolition of slavery grew more intense and the debates about citizenship had become stronger than ever.
|
2022-12-17T04:51:29.200Z
|
41,166,526 |
{
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"ArXiv": null,
"DOI": "10.1177/0003319717726474",
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},
"license": null,
"status": "BRONZE",
"url": "https://journals.sagepub.com/doi/pdf/10.1177/0003319717726474"
}
|
We thank Akboga et al for their interest in our article entitled “Endocan Levels and Coronary Collateral Circulation in Stable Angina Pectoris: A Pilot Study.” As they mention in their letter, we reported the role of endocan in systemic inflammation. We also previously reported the relationship between endocan and the presence of slow coronary flow and found that endocan was positively correlated with high-sensitivity C-reactive protein in that study. In another study, we demonstrated that endocan may be a useful predictor for short-term mortality and the severity of coronary artery disease in patients with ST-segment elevation myocardial infarctions. These studies support the role of endocan in systemic inflammation. However, we agree with Akboga et al that the role of inflammation in coronary collateral circulation (CCC) is not clearly defined. Some papers show a positive relationship between inflammation and well-developed CCC and others reported a negative relationship. Therefore, we believe that the role of inflammation in CCC still needs to be clarified.
|
2022-02-12T03:53:21.546Z
|
162,221,389 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1098/RSBM.1934.0007",
"MAG": "2086246211",
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|
On August 20, 1933, there passed away at the age of 77 one of the older Fellows of the Chemical Society, and yet another of the Oxford University staff of the Odling regime, in the person of Dr. Victor Herbert Veley, F.R.S. Those who worked in the University laboratories in the last decades of the past century and the first few years of the present will recollect with a sigh of affection the well-known spare figure with the humorous twinkle of the eye, and the clothes well stained with nitric acid ; and those Fellows in the habit of attending scientific meetings in London in the first decade of the present century will perhaps associate his presence with a certain unwonted liveliness .
|
2022-02-25T00:54:00.250Z
|
248,536,790 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0016756800115432",
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|
impression,' though shallow, is here well marked and about 13-5 mm. wide, but this may have been much narrower or even have entirely disappeared on the body-chamber, so that the transverse section of the body-chamber may have been more nearly digonal. Fortunately in the present specimen a few of the septa are visible, or at least partially visible; near the anterior end of the specimen they are about 6-0 mm. apart; they are, however, best displayed at about the commencement of the last third of the outer whorl, i.e. where the specimen is 69 mm. in diameter; here they are seen on a portion of the peripheral area and on a part also of the side of the whorl; on the lateral area they form a very slight backwardlydirected curve, and, crossing the umbilical rim, traverse the peripheral area in almost a straight line, or with only a very feeble baokwardlydirected curve; on the periphery they are about 70 mm. apart. So far as can be seen, the form of the septation closely resembles that of Vestinautllus pinguis as figured by Dr. Foord, but the chambers are a little shallower than shown in that figure. Notwithstanding the characters which differentiate this specimen from Foord's figured example, viz., the greater convexity of the peripheral area, the narrower and deeper hyponomic sinus, and the relatively greater height of the whorl in proportion to its width, there can be no doubt that the two forms are very closely allied and most probably specifically identical. In referring his species to the genus Vestinautilm, Dr. Foord seems, therefore, to be correct, the form of the septal sutures supporting that conclusion.
|
2022-06-14T18:56:44.828Z
|
206,893,480 |
{
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"DOI": "10.1111/1462-2920.12814",
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"license": null,
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc4914366?pdf=render"
}
|
Phospholipids are well known for their membrane-forming properties and thereby delimit any cell from the exterior world. In addition, membrane phospholipids can act as precursors for signals and other biomolecules during their turnover. Little is known about phospholipid signalling, turnover and remodelling in bacteria. Recently, we showed that a FadD-deficient mutant of Sinorhizobium meliloti, unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids during the stationary phase of growth. Enzymatic activities responsible for the generation of these free fatty acids were unknown in rhizobia. Searching the genome of S. meliloti, we identified a potential lysophospholipase (SMc04041) and two predicted patatin-like phospholipases A (SMc00930, SMc01003). Although SMc00930 as well as SMc01003 contribute to the release of free fatty acids in S. meliloti, neither one can use phospholipids as substrates. Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and that monoacylglycerol can be further degraded by SMc01003 to another fatty acid and glycerol. A SMc01003-deficient mutant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background. Expression of the DglA lipase in Escherichia coli causes lysis of cells in stationary phase of growth.
|
2022-09-08T19:12:07.538Z
|
240,181,462 |
{
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"ArXiv": null,
"DOI": "10.4103/njca.njca_65_20",
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"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://doi.org/10.4103/njca.njca_65_20"
}
|
Introduction: During pulmonary vein isolation ablation procedure, the knowledge of number and position of pulmonary veins with thickness of posterior wall of left atrium (LA) is of invaluable significance. The objective of the study was to determine the left atrial wall thickness (LAWT) and its relationship with number and variations of right pulmonary veins (RPVs) and left pulmonary veins (LPVs). Methodology: In an observational study, carried out in the Department of Anatomy, All India Institute of Medical Sciences, Raipur (Chhattisgarh), morphological variations of pulmonary veins among 75 formalin-fixed hearts were noted. The thickness of posterior wall of LA was measured in each specimen studied. The number of RPVs and LPVs was counted. Any sexual differences in these numbers were noted. Results: Normal anatomical description of two RPVs and two LPVs opening the LA was observed in 63 out of 75 heart specimens (84%). The posterior LAWT is ranged 1.28–1.48 mm where two RPVs and two LPVs enter LA. The remaining 12 specimens (16%) showed variation in the number of veins opening into LA ranging between 1 and 5 veins of either side. The posterior LAWT ranged between 1.01 and 2.53 mm in these 12 specimens. The mean posterior LAWT thickness with 3, 4, and 5 RPVs was 1.47, 1.94, and 2.43 mm, respectively. Conclusion: The thickness of posterior wall of LA increases as the number of RPVs increases. Twelve specimens (16%) showed variation in the number of veins opening into LA ranging between 1 and 5 veins of either side.
|
2022-12-02T19:20:19.909Z
|
56,194,958 |
{
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"ArXiv": null,
"DOI": "10.15700/SAJE.V37N1A1276",
"MAG": "2593750922",
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},
"license": null,
"status": null,
"url": null
}
|
Science education is particularly important for both developed and developing countries to promote technological development, global economic competition and economic growth. This study explored the relationship between family experiences, the motivation for science learning, and the science achievement of a group of Grade Nine learners in South Africa. A purposeful sample of 380 learners from three racial groups in public and independent schools completed the Student Motivation for Science Learning questionnaire combined with items investigating family experiences. The findings indicate that family experiences correlated significantly with three motivational aspects of science learning (self-efficacy, active learning and achievement goals); boys perceived family experiences significantly more positively than girls; and parental educational level as well as school values seemed to be related to science learning. Recommendations were made as to how schools can support families in enhancing family experiences that promote learners’ motivation for science learning and science achievement.
|
2022-12-14T18:26:35.151Z
|
125,905,640 |
{
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"ArXiv": null,
"DOI": "10.1109/TSMC.2018.2854294",
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"url": null
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|
How to understand and control the individual choices and cooperative conflicts in multiagent systems is a cross-over study which edges into multiple disciplines. An interdisciplinary mathematical tool to theoretically study the issue of cooperative dilemma is evolutionary game theory. The assumption of graphs that maps social interactions provides a useful approach for studying the dynamics in gaming systems, where its theoretical analysis is drop behind simulations. Here we perform analysis on game dynamics in a spatially distributed system situating on multiple-community networks. In the context of the three paradigmatic game prototypes (dominating games, coexistence games, and the coordination games), the stability of the equilibrium state emerging from this is provided. Further investigation on multicommunity system reveals that the community structure plays a key role in the stability of the strategy evolution. Besides, our explorations toward the multiple strategies adopted by the population whose interactions include ${n}$ communities, certify that the payoff is crucial for individuals’ dominating superiority over others in the system. The results are expected to provide effective perspective to control the individual choice in large systems, and lend itself to multiple applications in control engineering perspective.
|
2022-12-18T01:37:15.987Z
|
146,791,794 |
{
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"ArXiv": null,
"DOI": "10.1002/PSP.490",
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},
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"status": null,
"url": null
}
|
With increasing economic integration and social interactions between Hong Kong and Mainland China, cross-border marriages between the two have increased substantially, while the sex ratio of the 25–44 age group has decreased to less than one. The influx of Mainland brides, together with ever-increasing unmarried women in Hong Kong, have put increased pressure on its social and welfare services, and reducing barriers for Hong Kong men seeking Hong Kong women has a significant bearing on social policies. Based on a theoretical perspective that combines assortative mating and societal disparity, the current study examined cross-border marriages in Hong Kong between 1998 and 2005. It was found that Hong Kong grooms with Mainland brides were less likely than Hong Kong grooms with Hong Kong brides to be assortative in terms of education, occupation and natal community. It was also found that Hong Kong grooms often married much younger brides due to their own delayed marriages and second plus marriages. Copyright © 2008 John Wiley & Sons, Ltd.
|
2022-12-23T08:20:53.680Z
|
231,576,457 |
{
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"ArXiv": null,
"DOI": "10.1097/MLR.0000000000001496",
"MAG": null,
"PubMedCentral": "7993651"
},
"license": null,
"status": null,
"url": null
}
|
Supplemental Digital Content is available in the text.
|
2022-12-24T14:41:51.549Z
|
240,448,396 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17221/29/2016-rae",
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},
"license": "publisher-specific license",
"status": "GOLD",
"url": "https://www.agriculturejournals.cz/publicFiles/29_2016-RAE.pdf"
}
|
After harvesting, soybean seed must be thermally treated because of the increased moisture content. The most common thermal treatment of soybean is roasting, with three indicators that are critical for the process itself: seed moisture content, roasting period and process temperature. Following the above-mentioned, the aim of this paper was to determine nutritional and energy changes in three soybean varieties (‘Gordana’, ‘Sivka’ and ‘Slavonka’). After collecting the samples, the nutrient structure of the core and energy components of seed hull for each variety were determined before and after the heat treatment by roasting. The roasted soybean seeds of the specified varieties were dried by exposure to temperatures of 125°C and 135°C in the duration of 10, 20 and 30 minutes. The results show that significant changes occurred in nutritional properties of soybean seed core in relation to temperature and time of roasting, as well as to assortment. There are also significant differences in elements, which affects the energy properties of soy seed hulls depending on temperature and duration of the procedure.
|
2022-01-27T12:25:44.141Z
|
222,897,246 |
{
"externalids": {
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"DOI": "10.3760/CMA.J.ISSN.1673-4904.2008.21.010",
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|
Objective To determine the therapeutic effect of IgA nephropathy treated with tonsillectomy, and investigate the indication and contraindication. Methods Thirty-five IgA nephropathy patients, who were diagnosed by renal biopsy treated with tonsillectomy, were in operation group. Twenty-four hours urine protein, one hour urine erythrocyte and serum creatine were detected before the operation, one week, two weeks, four weeks, six months after the operation. Compared with 40 IgA nephropathy patients, who were treated with medicine (control group). Results The effective power in operation group was 71.4% and in control group was 52.5%. There was significant difference between two groups. Conclusion Tonsillectomy is more effective in IgA nephropathy with chronic tonsillitis, especially when renal corpuscle is slightly impaired, conversely, when renal function is severely damaged, it belongs to surgical contraindication.
Key words:
Glomerulonephritis,IgA; Tonsillectomy; Indications
|
2022-01-27T13:09:39.998Z
|
39,279,015 |
{
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"ArXiv": null,
"DOI": "10.2307/3574244",
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"status": null,
"url": null
}
|
Previous studies demonstrated a stimulated AIB transport in the liver of rats after whole-body $gamma$ irradiation. The present work is an expansion of those studies and reports that the irradiation-stimulated, hepatic transport is time-related and dose-dependent. The uptake was followed for the first 72 hr after exposure to a range of doses between 500 and 2500 R. The transport increased over the entire 72 hr investigated between the 500 and 1500 R levels; that at 1500 R being increased 400 percent at 72 hr postirradiation. At the 2000 and 2500 R doses the uptake increased 200 to 300 percent, reaching a maximum at 48 hr after exposure. During the next 24 hr the AIB accumulation at both of these doses decreased, with that at 2500 R declining to normal values and that at 2000 R being slightly higher. Whole-body irradiation also resulted in an elevated accumulation of AIB in the kidney. Maximal uptake occurred 48 hr postirradiation for all doses. At 72 hr the accumulation declined to near or below control values for all doses except 250 and 500 R. The AIB transports for three other tissues, spleen, testes, and muscle were not stimulated by whole-body irradiation. The mechanism bymore » which this amino acid transport system is stimulated remains to be established. (auth)« less
|
2022-02-12T05:27:27.262Z
|
6,373,698 |
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"DOI": "10.1185/03007997409111874",
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"status": null,
"url": null
}
|
A study was conducted on 10 healthy young women who had taken oral contraceptives of the combined type for several cycles. Daily treatment was instituted with a high-potency vitamin B complex with vitamin C ("Surbex 500"). Blood specimens were collected before and after treatment with this vitamin supplement and plasma levels of ascorbic acid and vitamin B12 were measured. Activity of red cell aspartate amino-transferase (AST) was determined before and after the in vitro addition of excess pyridoxal phosphate, and of glutathione reductase (GTR) before and after the in vitro addition of excess flavin adenine dinucleotide. Women taking oral contraceptives showed plasma concentrations of ascorbic acid and vitamin B 12 below the range seen in a matched group of untreated women, while red cell AST and GTR were less saturated by their essential co-factors. Daily treatment with"Surbex 500" restored all four biochemical indices of vitamin nutrition to the normal ranges.
|
2022-06-24T08:33:16.018Z
|
72,045,724 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/ARCHNEUR.55.4.575",
"MAG": "2022528289",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
clinical applications of neurotrophic factors. Book lovers, when you need a new book to read, find the book here. Never worry not to find what you need. Is the clinical applications of neurotrophic factors your needed book now? That's true; you are really a good reader. This is a perfect book that comes from great author to share with you. The book offers the best experience and lesson to take, not only take, but also learn.
|
2022-09-15T02:55:12.515Z
|
237,936,798 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/molecules26185723",
"MAG": null,
"PubMedCentral": "8465053"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1420-3049/26/18/5723/pdf?version=1633935453"
}
|
Acne vulgaris is a highly prevalent skin disorder requiring treatment and management by dermatologists. Antibiotics such as clindamycin are commonly used to treat acne vulgaris. However, from both medical and public health perspectives, the development of alternative remedies has become essential due to the increase in antibiotic resistance. Topical therapy is useful as a single or combined treatment for mild and moderate acne and is often employed as maintenance therapy. Thus, the current study investigated the anti-inflammatory, antibacterial, and restorative effects of sesquiterpene farnesol on acne vulgaris induced by Cutibacterium acnes (C. acnes) in vitro and in a rat model. The minimum inhibitory concentration (MIC) of farnesol against C. acnes was 0.14 mM, and the IC50 of 24 h exposure to farnesol in HaCaT keratinocytes was approximately 1.4 mM. Moreover, 0.8 mM farnesol exhibited the strongest effects in terms of the alleviation of inflammatory responses and abscesses and necrotic tissue repair in C. acnes-induced acne lesions; 0.4 mM farnesol and clindamycin gel also exerted similar actions after a two-time treatment. By contrast, nearly doubling the tissue repair scores, 0.4 mM farnesol displayed great anti-inflammatory and the strongest reparative actions after a four-time treatment, followed by 0.8 mM farnesol and a commercial gel. Approximately 2–10-fold decreases in interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, found by Western blot analysis, were predominantly consistent with the histopathological findings and tissue repair scores. The basal hydroxypropyl methylcellulose (HPMC) gel did not exert anti-inflammatory or reparative effects on rat acne lesions. Our results suggest that the topical application of a gel containing farnesol is a promising alternative remedy for acne vulgaris.
|
2022-11-26T06:59:52.790Z
|
214,094,925 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1142/s2377740019500180",
"MAG": "3003523608",
"PubMedCentral": null
},
"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.1142/s2377740019500180"
}
|
This article examines the status politics in Chinese foreign policy and its implications on China-U.S. relations. The analysis of status recognition and the role it plays in Chinese diplomacy reveals the motivating factors behind China’s quest for respect in the international arena and the centrality of national identity in China’s status aspiration. Viewed from the socio-psychological perspective, China’s tenacious struggle to gain a prominent international status is a social action aimed at forging its identity security, whereby the Chinese “self” will interact on equal terms with the foreign “other.” Based on the argument, this paper compares Chinese and American role conceptions and dissects the status dilemma between the two powers by exploring the dynamics of disrespect in their status relations. The two nations’ distinctive self-role conceptions and their role expectations of the interacting parties have led to a widening gap between China’s international status that entitles it to equal treatment and the one accorded by the United States. The disquieting condition of this status dissonance has motivated Beijing to disrupt the asymmetric hierarchy wherein it used to exhibit deference to Washington. The effort of the established hegemon in upending the defiance of the status contestant has exacerbated the status dilemma, which has given rise to the current China-U.S. malaise.
|
2022-12-08T17:39:17.301Z
|
30,198,443 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1152/AJPREGU.2000.278.3.R598",
"MAG": "2263532485",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The specific role of each subtype of thyroid hormone receptor (TR) on skeletal muscle function is unclear. We have therefore studied kinetics of isometric twitches and tetani as well as fatigue resistance in isolated soleus muscles of R-α1- or -β-deficient mice. The results show 20–40% longer contraction and relaxation times of twitches and tetani in soleus muscles from TR-α1-deficient mice compared with their wild-type controls. TR-β-deficient mice, which have high thyroid hormone levels, were less fatigue resistant than their wild-type controls, but contraction and relaxation times were not different. Western blot analyses showed a reduced concentration of the fast-type sarcoplasmic reticulum Ca2+-ATPase (SERCa1) in TR-α1-deficient mice, but no changes were observed in TR-β-deficient mice compared with their respective controls. We conclude that in skeletal muscle, both TR-α1 and TR-β are required to get a normal thyroid hormone response.
|
2022-12-10T14:14:28.886Z
|
31,386,766 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1006/ABBI.1993.1442",
"MAG": "2059299674",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The modulation of the plasma membrane calcium pump (PMCA) gene expression is not well understood. We now present evidence that PMCA mRNA is induced by various hormones or agonists via multiple second messenger pathways that include protein kinase C-, cAMP-, and Ca(2+)-dependent mechanisms. Among several types of cultured cells examined, endothelial cells from the rat aorta (RAEC) responded to phorbol ester or angiotensin II with an 8- to 20-fold increase in the PMCA messages, while endothelial cells from the brain resistant vessel (RVEC) exhibited minimal (0- to 2-fold) response to these agonists. On the other hand, under the stimulation of cAMP or thapsigargin (a calcium mobilizing agent), the pattern of response is reversed; only RVEC responded but not RAEC. The results suggest that hormone-induced PMCA gene expression is regulated via two distinct pathways; one involves protein kinase C while the other involves Ca2+ or cAMP. Since the protein kinase A inhibitor (or the calmodulin-dependent kinase inhibitor) was able to block the stimulation elicited by either Ca2+ or cAMP, we suggest that the Ca2+ and cAMP signals share a common passage leading to the induction of PMCA mRNA. The possibility of cross-talk between the distinct second messenger pathways is also discussed.
|
2022-12-12T04:49:03.787Z
|
213,165,270 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5197/j.2044-0588.2020.041.001",
"MAG": "2996900333",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.5197/j.2044-0588.2020.041.001"
}
|
In summer 2019, a previously unknown disease occurred in greenhouses of c. 30 cucumber growers in Bavaria, Germany. From the first symptoms, a severe disease developed with weaker symptoms on younger leaves but strong chlorosis associated …
|
2022-12-18T01:47:55.027Z
|
2,581,134 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1365-2052.2007.01651.X",
"MAG": "2133708384",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Here we report radiation hybrid mapping of 105 new porcine microsatellite markers on the IMpRH(7000) radiation hybrid panel. In addition, we searched flanking sequences of these markers, as well as 673 previously reported RH-mapped microsatellite markers, for orthology to human sequences. Eighty-seven new and 111 previously mapped sequences exhibited orthology to human sequences. Using a stringent sequence alignment, 25 microsatellite-flanking sequences were found to be highly similar to genic sequences, whereas 173 were similar to non-genic sequences in the human genome. Five markers were located near known breakpoints of synteny between human and swine.
|
2022-02-13T13:31:52.310Z
|
53,446,628 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21275/art20178696",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.21275/art20178696"
}
|
To assess the effectiveness of structured teaching programme on knowledge and practices of pediatric nurses regarding care of children on mechanical ventilator. Pre experimental research design i.e. one group pre-test and posttest design was adopted for this study. The subjects selected for the study were pediatric nurses working in pediatric intensive care unit, neonatal intensive care unit and pediatric ward. The study participants were selected by non probability convenient sampling technique. Knowledge of pediatric nurses was assessed by structured questionnaire and practices were assessed by three point scale check list. The study findings revealed that the mean and standard deviation and paired ‘t’ value on knowledge on care of children on mechanical ventilator in pre test (15.38, 4.23) and post test mean and standard deviation (23.80, 2.61) and ‘t’ value=17.76.The mean and standard deviation and paired ‘t’ value on practices on care of children on mechanical ventilator in pre test (40.88, 7.33), in post test (55.30,2.74) and ‘t’ value =16.56, there was significant association between age and experience of the nurses with knowledge and practices.
|
2022-07-11T18:03:34.900Z
|
249,698,505 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14202/vetworld.2022.1481-1488",
"MAG": null,
"PubMedCentral": "9375202"
},
"license": "CCBY",
"status": "GOLD",
"url": "http://www.veterinaryworld.org/Vol.15/June-2022/10.pdf"
}
|
Background and Aim: Lepidium meyenii Walp (Maca) is an herbaceous plant that grows in the Peruvian Andes and it has been widely used as a nutritional supplement and fertility enhancer and has been used in the treatment of a variety of diseases, such as rheumatism, respiratory disorders, and anemia. The most notable feature of Maca is its potent antioxidant capacity, which helps in the scavenging of free radicals and protection of cells from oxidative stress. This study aimed to evaluate the in vitro effect of Maca extract on thawed sperm cells from bulls. Materials and Methods: Three dilutions of 1, 10, and 100 mg/mL of Maca extract were incubated with frozen–thawed bovine semen and analyzed at 1, 3, and 24 h of exposure time, evaluating the activity of the extract on the DNA, motility, morphology, viability, integrity of the membrane and acrosome of spermatozoa. Results: The Maca extract improved the studied sperm parameters of motility, acrosome integrity, vitality, and DNA integrity of sperm cells at a concentration of 10 mg/mL, and at 1 mg/mL, an improvement was observed in the morphology and integrity of the membrane. However, the best activity of the Maca extract was observed on the DNA integrity of the sperm, which was effective at the three concentrations evaluated after 24 h of incubation. Conclusion: The results indicate that L. meyenii can help in maintaining spermatozoa cellular integrity after the frozen–thaw process, especially in the protection against DNA fragmentation. Therefore, Maca would be a feasible supplementation to protect sperm to maintain their fertile ability after thawing.
|
2022-09-02T03:43:09.965Z
|
154,545,407 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00076799200000086",
"MAG": "2049131324",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In the 1960s, three of the 12 largest banks in the world were Canadian. Now, none are among the largest 25. The early growth and current more focused strategies must both be understood in relation to federal public policy. Canadian multinational banks (MNBs) developed in a country dependent upon inward capital flows to develop its natural resource base. Government concerns over stability were instrumental in creating a protected market in which Canadian banks developed competitive advantages for international competition. However, globalisation altered the ability of regulators to promote both stability and global competitiveness. The complex relationships between regulation and competitiveness is analysed for six historical periods: strangled trade and the origins of Canadian MNBs, 1792–1871; new nation, new national policy and new national banks, 1871–1900; mergers and new internationalisation, 1900–34; new corporate markets in Canada and abroad, 1934–67; the new international banking; the Euromarkets, ...
|
2022-09-09T07:16:46.332Z
|
83,995,909 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2520/MYCO1975.1988.1SUPPLEMENT_3",
"MAG": "1970431658",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
(PSP toxins) are usually detected by mouse assay (ref. 1, 2). Mouse assay is a simple and reliable method, but consumes relatively large amount of toxin. Signs of mice including death caused by the toxin are often indistinguishable from those induced by other compounds. Recently, Kogure et al. (ref .3) demonstrated a new assay method for detection of sodium channel blockers, using culture of mouse neuroblast cells. This method is much more sensitive and clearly shows the presence of these toxins. The present study deals with application of this method to quantitative analysis of PSP toxins. The stock solution of saxitoxin (STX) was diluted with distilled water to make a series of diluted solutions. A portion of the diluted solution was injected into mice intraperitoneally. The amount of toxin was calculated from death time of mice using dose-death time table of STX (ref. 1). The toxicity of the solution was expressed as mouse units (MU)/ml where one MU is the dose of toxin to kill a male 20-g mouse (ddY strain) in 15 min. Series of diluted solutions of STX derivatives such as neoSTX, gonyautoxins (GTXs) 2, 3, 5, 6 and 8 were also prepared in the same manner. Mouse neuroblast cells (neuro-2a; ATCC C(G131) were prepared for assay according to Kogure et al. (ref. 3). About 30,000 cells suspended in 200 ƒÊl of RPMI 1640 medium (Nissui Pharmaceutical Co. Ltd.) containing 13.5% FBS (Gibco) were transferred into each well of a microplate (Corning) and incubated at 37 •Ž overnight. After removal of 40 ƒÊl of medium from each well, 10 ,ul of 1 mM veratridine (30% ethanol solution), 20 ƒÊl of 10 mM ouabain and 10 ul of a series of diluted PSP toxin solutions were added to each well to make the total volume to 200 ƒÊl. After 6 hours incubation at 37•Ž, more than 200 cells were observed under an inverted microscope to calculate the survival ratio of the cells. Each sample was assayed in triplicate. Survival ratio of neuroblast cells increased with the toxin concentration. As shown in Fig. 1, the standard curve for STX coincides with those of the other PSP toxins, when survival ratio is plotted against toxicity, showing that this
|
2022-09-13T04:22:40.115Z
|
191,469,343 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/EARLYJ/XX.3.373",
"MAG": "2083437928",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Dido and Aeneas was first performed in 1689 by the
young lady pupils at Josias Priest's Chelsea boardingschool.
It was offered as a loyal tribute to William and
Mary on their coronation day, 21 April, or on Mary's
birthday, 30 April Priest had commissioned it specially;
the librettist and composer took care not to over-stretch
the modest resources of the school. These points, long
established by scholars, serve to support the impressive
edifice of modern commentary on Dido and Aeneas. Yet
a careful survey suggests that the building is founded on
sand
|
2022-09-13T03:19:27.257Z
|
10,507,204 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3233/sat190026",
"MAG": "2140327811",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://content.iospress.com:443/download/journal-on-satisfiability-boolean-modeling-and-computation/sat190026?id=journal-on-satisfiability-boolean-modeling-and-computation%2Fsat190026"
}
|
This paper is concerned with the complexity of some natural subclasses of minimal unsatisable formulas. We show the D P {completeness of the classes of maximal and marginal minimal unsatisable formulas. Then we consider the class Unique{MU of minimal unsatisable formulas which have after removing a clause exactly one satisfying truth assignment. We show that Unique{MU has the same complexity as the unique satisabilit y problem with respect to polynomial reduction. However, a slight modication of this class leads to the D P {completeness. Finally we show that the class of minimal unsatisable formulas which can be divided for every variable into two separate minimal unsatisable formulas is at least as hard as the unique satisabilit y problem.
|
2022-09-14T20:45:46.174Z
|
218,517,942 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/3397461",
"MAG": "3041449006",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://dl.acm.org/doi/pdf/10.1145/3397461"
}
|
Deep learning now offers state-of-the-art accuracy for many prediction tasks. A form of deep learning called deep convolutional neural networks (CNNs) are especially popular on image, video, and time series data. Due to its high computational cost, CNN inference is often a bottleneck in analytics tasks on such data. Thus, a lot of work in the computer architecture, systems, and compilers communities study how to make CNN inference faster. In this work, we show that by elevating the abstraction level and re-imagining CNN inference as queries, we can bring to bear database-style query optimization techniques to improve CNN inference efficiency. We focus on tasks that perform CNN inference repeatedly on inputs that are only slightly different. We identify two popular CNN tasks with this behavior: occlusion-based explanations (OBE) and object recognition in videos (ORV). OBE is a popular method for “explaining” CNN predictions. It outputs a heatmap over the input to show which regions (e.g., image pixels) mattered most for a given prediction. It leads to many re-inference requests on locally modified inputs. ORV uses CNNs to identify and track objects across video frames. It also leads to many re-inference requests. We cast such tasks in a unified manner as a novel instance of the incremental view maintenance problem and create a comprehensive algebraic framework for incremental CNN inference that reduces computational costs. We produce materialized views of features produced inside a CNN and connect them with a novel multi-query optimization scheme for CNN re-inference. Finally, we also devise novel OBE-specific and ORV-specific approximate inference optimizations exploiting their semantics. We prototype our ideas in Python to create a tool called Krypton that supports both CPUs and GPUs. Experiments with real data and CNNs show that Krypton reduces runtimes by up to 5× (respectively, 35×) to produce exact (respectively, high-quality approximate) results without raising resource requirements.
|
2022-10-02T14:32:17.942Z
|
137,305,407 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.49945",
"MAG": "1523880999",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The Wake Shield Facility (WSF) created to characterize and utilize the ultra‐vacuum of space has flown its second mission on Endeavor, STS‐69 in September, 1995. In its second flight the WSF flew free behind the Orbiter at a nominal distance of 25 nmi, grew four semiconductor thin film samples by molecular beam epitaxy, and one oxide thin film sample through the use of LEO atomic oxygen. The semiconductor thin films were in the III‐V semiconductor area with focus on AlGaAs/GaAs system. The WSF also generated an ultra‐vacuum consistent with past predictions of space wake vacuum levels. In addition, eleven cooperative experiments were flow on the WSF yielding additional information on the low earth orbit space environment.
|
2022-02-09T10:44:15.075Z
|
119,415,092 |
{
"externalids": {
"ACL": null,
"ArXiv": "1902.08170",
"DOI": "10.1063/1.5096487",
"MAG": "2917131493",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://arxiv.org/pdf/1902.08170"
}
|
A convenient approach to analyze spatial infinity is to use a cylinder representation $I$ and impose a gauge based on a congruence of conformal geodesics. This so-called conformal Gauss gauge comes along with the freedom to specify initial data for the conformal geodesics. Such a gauge has been constructed from an ordinary Cauchy surface and from past null infinity $\mathcal{J}^-$, respectively. The purpose of this note is to compare these gauges near the critical set $I^-$, where $I$ "touches" $\mathcal{J}^-$, as it turns out that they are related in a somewhat unexpected intricate way.
|
2022-12-17T05:35:27.009Z
|
132,560,128 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5751/ES-07087-200153",
"MAG": "2513625649",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
[Extract] Humans all over the planet are struggling and aspiring to engage with the scale and scope of the challenge of achieving human well-being and environmental stewardship for all. This special feature presents the products of processes in Southern Africa that have explored the potential use of complexity approaches to tackling the substantial social-ecological challenges in the region. Although the papers composing the special feature draw mainly on South African case studies, the thinking and participation in development processes were inclusive of the broader region.
A concept that emerges through the papers is the inevitable conflation of human well-being and justice, and together they point toward social and ecological justice as an expression of human well-being, founded on environmental stewardship. Over the time the constituent papers have emerged, Mark Swilling and Eve Annecke have produced a most elegantly written and argued book Just Transitions (Swilling and Annecke 2012) that foregrounds the justice theme, deepens and complements several of the perspectives collectively presented in this feature, particularly complexity-based research, and adds an important economics lens.
|
2022-12-23T02:16:09.391Z
|
26,598,263 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/JOM.0b013e318169ccd0",
"MAG": "1995850842",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: Examination of the relationship of impairment to disability in the work psychiatry context and identification of practical strategies for occupational physicians to apply to screening, management, and appropriate referral. Methods: Medical literature review. Results: The determination and differentiation of impairment and disability is a complex psychiatric task which requires consideration of the type of employment, assessment of depression-related functional impairments that can create disability for a particular occupation, and individual factors. Conclusions: The authors propose a new and more consistent strategy for identifying impairment severity and its impact on employment, including simple procedures to screen for depression and guidelines to minimize role and boundary confusion.
|
2022-12-24T14:54:08.517Z
|
255,091,024 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.37989/gumussagbil.1000897",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://dergipark.org.tr/tr/download/article-file/1995161"
}
|
Bu çalışmada COVID-19 pandemi sürecinde aktif rol alan sağlık personelinin umutsuzluk, depresyon ve travma sonrası büyüme durumlarının belirlenmesi amaçlanmıştır. 15 Aralık 2020 - 15 Mart 2021 tarihleri arasında Türkiye'de gerçekleştirilen kesitsel tanımlayıcı bir çalışmadır. Araştırmaya uygun örnekleme yöntemiyle sosyal medya platformlarından ulaşılan COVID-19 tanılı hastalarla çalışan 132 sağlık personeli dahil edilmiştir. Araştırma verileri bireylerin; sosyo demografik özelliklerini belirlemeye ilişkin sorular ile depresyon, umutsuzluk ve travma sonrası büyüme ölçeklerini içeren online veri toplama aracı kullanılarak toplanmıştır. Veriler, IBM SPSS 21 istatistik programında analiz edilmiştir. Çalışmamızda yaş, cinsiyet, eğitim durumu, çalışma durumu, medeni durum gibi değişkenlerle ölçek puanları arasında anlamlı bir ilişki saptanmamıştır. Buna karşın psikolojik yardım almayı isteme ile depresyon puanları arasında istatistiksel olarak pozitif yönde anlamlı bir ilişki saptanmıştır. Travma sonrası büyüme ölçeği toplam puanı ile alt ölçeklerinden Kişisel Güçlülük, Manevi Değişim, Yaşamı Takdir Etme puanları ile umutsuzluk ölçeği puanları arasında ters yönde istatistiksel olarak anlamlı ilişki saptanmıştır. Araştırmamızın bulguları gelecekteki olası pandemilerle karşılaşabilmeleri muhtemel olan sağlık personellerinin, psikolojik olarak güçlendirilmesinin önemini ortaya koyması bakımından önemlidir. Umut düzeyi daha yüksek sağlık personellerinin pandemi süreçlerinden daha az travmatize olmaları göz önüne alındığında, sağlık personellerine yapılacak psikolojik rehabilitasyon çalışmalarında umudu geliştirmeye yönelik müdahalelere yer verilmesi önerilebilir.
|
2022-12-30T00:54:30.050Z
|
31,362,070 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/10715769900300081",
"MAG": "1991945233",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Apoptosis has been associated with oxidative stress in biological systems. Caspases have been considered to play a pivotal role in the execution phase of apoptosis. However, which caspases function as executioners in reactive oxygen species (ROS)-induced apoptosis is not known. The present study was performed to identify the major caspases acting in ROS-induced apoptosis. Treatment of HL-60 cells with 50 microM hydrogen peroxide (H2O2) for 4 h induced the morphological changes such as condensed and/or fragmented nuclei, increase in caspase-3 subfamily protease activities, reduction of the procaspase-3 and a DNA fragmentation. To determine the role of caspases in H2O2-induced apoptosis, caspase inhibitors, acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone (Ac-YVAD-cmk), acetyl-Asp-Glu-Val-Asp-aldehyde (Ac-DEVD-CHO) and acetyl-Val-Glu-Ile-Asp-aldehyde (Ac-VEID-CHO), selective for caspase-1 subfamily, caspase-3 subfamily and caspase-6, respectively, were loaded into the cells using an osmotic lysis of pinosomes method. Of these caspase inhibitors, only Ac-DEVD-CHO completely blocked morphological changes, caspase-3 subfamily protease activation and DNA ladder formation in H2O2-treated HL-60 cells. This inhibitory effect was dose-dependent. These results suggest that caspase-3, but not caspase-1 is required for commitment to ROS-triggered apoptosis.
|
2022-12-30T17:58:11.348Z
|
208,097,871 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17586/2226-1494-2019-19-5-801-808",
"MAG": "2980792625",
"PubMedCentral": null
},
"license": "publisher-specific license",
"status": "GOLD",
"url": "https://ntv.ifmo.ru/file/article/18956.pdf"
}
|
Аннотация Предмет исследования. Рассмотрены гидрообъективы для исследования Мирового океана, в том числе его Арктической зоны. Вопросы проведения работ на небольших глубинах и шельфе считаются решенными, активно ведутся работы на средних глубинах — 300–500 м, поэтому наиболее актуальными становятся проекты, связанные с изучением больших глубин. Эти задачи являются комплексными и мультидисциплинарными и, безусловно, требуют больших научных, технических и финансовых вложений для их решений и способны обеспечить замещение дорогостоящей импортной техники. По степени сложности они не уступают вопросам освоения космического пространства. Метод. Максимум внимания уделяется проектированию специализированных оптических систем, обеспечивающих формирование, ввод и передачу визуальной информации от удаленных объектов, которую невозможно получить какими-либо другими способами. При проектировании таких систем важно понимать роль и назначение каждого элемента. Эти знания помогают разработчику найти оптимальное решение для выбора начальной точки оптической системы. В основу методов проектирования был положен опыт Университета ИТМО в разработке оптических схем гидрообъективов и их внедрении в отечественные проекты по освоению Мирового океана. Основной подход, применяемый при проектировании гидрообъективов, заключается в сочетании анализа известных решений, их классификации, рекомендаций оптиков-экспертов, специализирующихся в этой области, а также структурном и параметрическом синтезе с последующей автоматизированной коррекцией схем объективов. В последние годы активно применяется виртуальное прототипирование моделей гидрообъективов и их взаимодействие с внешней средой. Основные результаты. Основные результаты и их практическая значимость заключаются в разработке методики расчета гидрообъективов для глубоководных исследований и создании ряда гидрообъективов для решения научно-прикладных задач. В работе приведены схемы некоторых объективов. Практическая значимость. Разработанные гидрообъективы могут использоваться для решения различных научных и хозяйственных задач на больших глубинах Мирового океана, вплоть до максимальных. Ключевые слова проектирование оптических систем, гидрообъектив, глубоководные объективы, защитные иллюминаторы, объективы с вынесенными входными зрачками, виртуальное прототипирование, аберрации
|
2022-07-11T01:15:33.265Z
|
96,758,762 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00397917709409269",
"MAG": "2949867476",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Das aus dem entsprechenden Phthalid mit Lithiumdiisopropylamid in Tetrahydrofuran bei -78°C hergestellte Anion (I) reagiert mit ungesattigten Estern und Ketonen oder Acrylnitril zu den Addukten (II).
|
2022-09-01T22:36:30.278Z
|
213,419,137 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4000/terrain.18955",
"MAG": "2994230234",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://doi.org/10.4000/terrain.18955"
}
|
This article describes the afterlife of the 1952 Scelba Law in Italy, which forbids “apologias” for the fascist regime, and its chequered history of application. Intended to censor, amongst other things, speech directed towards the reconstitution of an Italian fascist party, fascist propaganda, and fascist demonstrations, the Scelba Law has been sparingly and inconsistently applied. This is particularly evident in the village of Predappio, Mussolini’s home town, and one of Italy’s premier sites of neo-fascist tourism. This article explores the ways in which the pointed absence of censorship in Predappio constitutes an intervention in a wider set of debates surrounding how to identify “fascism” as an object. It thus highlights the value of examining not only the productivity of censorship as a practice and vocation but also the potentially productive force of abstaining from censorship.
|
2022-09-08T23:01:56.798Z
|
13,006,286 |
{
"externalids": {
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"ArXiv": null,
"DOI": "10.1109/MCOM.2013.6515047",
"MAG": "2110327236",
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},
"license": null,
"status": null,
"url": null
}
|
The large increase in size and complexity experienced by cellular networks in recent years has led to a new paradigm known as heterogeneous networks, or HetNets. In this context, networks with different cell sizes, radio access technologies, or carrier frequencies can be deployed in the same environment. As the coverage area of each of these networks is typically overlapped, operators have some degree of freedom to modify user distributions across the networks (i.e., traffic steering) in order to improve network performance. This article introduces different mechanisms of traffic steering in HetNets, clarifying the specific goals that operators can set and focusing on those techniques that adjust mobility parameters, which are typically more attractive to achieve these goals. In addition, some challenging issues arising from particular HetNet deployments are discussed and illustrated by example use cases, which are applicable to an early stage of LTE deployment. Finally, a fuzzy-logic-based algorithm that optimizes network parameters for traffic steering is proposed.
|
2022-12-14T12:32:52.565Z
|
219,143,740 |
{
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"ArXiv": null,
"DOI": "10.33635/sitefa.v2i1.82",
"MAG": "3023133672",
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},
"license": null,
"status": "BRONZE",
"url": "https://sitefa.fatecsertaozinho.edu.br/index.php/sitefa/article/download/82/62"
}
|
Este artigo tem como objetivo analisar e identificar os motivos pelos quais as empresas estudadas aplicam a Logistica Reversa e como, a partir desse processo, conseguiram buscar beneficios, alem de reduzir custos. Com o constante avanco do conhecimento da populacao em geral e um mundo cada vez mais globalizado, a Logistica Reversa chega para agregar valor a esse cenario, trazendo, em sua amplitude, a preocupacao com o retorno dos produtos de pos-venda ou pos-consumo. Apos analise das empresas O Boticario, Natura, Soya e Liza, por meio de informacoes disponibilizadas nos sites das empresas, foi possivel observar que o primeiro motivo para aplicar esse processo e a preocupacao com a legislacao ambiental, pois as empresas geram constantemente residuos que precisam ter uma destinacao correta. Nota-se que, apos cumprimento das leis ambientais, surgem ideias e inovacoes, fazendo com que as embalagens descartadas sejam recolhidas e encaminhadas para o processo de reciclagem, gerando renda, empregos para a populacao e parcerias com pequenas empresas. Ha tambem a utilizacao do oleo usado para a producao de biodiesel, que pode ser vendido para diversas finalidades, gerando receita para as empresas, alem de reduzir a poluicao de milhares de litros de agua e evitar a emissao de Co². Dessa maneira, o desejavel e que os consumidores analisem e adquiram produtos de empresas responsaveis ambientalmente.
|
2022-12-20T23:53:39.233Z
|
30,124,936 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1002/9780470050118.ecse014",
"MAG": "1963310225",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Analog-to-digital converters (ADCs) continue to be important components of signal-processing systems, such as those for mobile communications, software radio, radar, satellite communications, and others. This article revisits the state-of-the-art of ADCs and includes recent data on experimental converters and commercially available parts. Converter performances have improved significantly since previous surveys were published (1999–2005). Specifically, aperture uncertainty (jitter) and power dissipation have both decreased substantially during the early 2000s. The lowest jitter value has fallen from approximately 1 picosecond in 1999 to < 100 femtoseconds for the very best of current ADCs. In addition, the lowest values for the IEEE Figure of Merit (which is proportional to the product of jitter and power dissipation) have also decreased by an order of magnitude. For converters that operate at multi-GSPS rates, the speed of the fastest ADC IC device technologies e.g., InP, GaAs, is the main limitation to performance; as measured by device transit-time frequency, fT, has roughly tripled since 1999. ADC architectures used in high-performance broadband circuits include pipelined (successive approximation, multistage flash) and parallel (time-interleaved, filter-bank) with the former leading to lower power operation and the latter being applied to high-sample rate converters. Bandpass ADCs based on delta-sigma modulation are being applied to narrow band applications with ever increasing center frequencies. CMOS has become a mainstream ADC IC technology because (1) it enables designs with low power dissipation and (2) it allows for significant amounts of digital signal-processing to be included on-chip. DSP enables correction of conversion errors, improved channel matching in parallel structures, and provides filtering required for delta-sigma converters. Finally, a performance projection based on a trend in aperture jitter predicts 25 fs in approximately 10 years, which would imply performance of 12 ENOB at nearly 1-GHz bandwidth.
Keywords:
analog-to-digital converters;
signal-to-noise ratio;
aperture jitter;
input-referred noise;
comparator ambiguity;
spurious-free dynamic range;
digital-signal-processing
|
2022-12-21T20:52:16.966Z
|
52,879,634 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0204580",
"MAG": "2894288985",
"PubMedCentral": "6160115"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0204580&type=printable"
}
|
Following a certain type-specific number of mitotic divisions, terminally differentiated cells undergo proliferative senescence, thwarting efforts to expand different cell populations in vitro for the needs of scientific research or medical therapies. The primary cause of this phenomenon is the progressive shortening of the telomeres and the subsequent activation of cell cycle control pathways leading to a block of cell proliferation. Restoration of telomere length by transgenic expression of telomerase reverse transcriptase (TERT) usually results in bypassing of the replicative senescence and ultimately in cell immortalization. To date, there have not been any reports regarding immortalization of cells from common marmoset (Callithrix jacchus), an important non-human primate model for various human diseases, with the use of exogenous human TERT (hTERT). In this study, marmoset fibroblasts were successfully immortalized with transposon-integrated transgenic hTERT and expanded in vitro for over 500 population doublings. Calculation of population doubling levels (PDL) showed that the derived hTERT-transgenic lines had significantly higher proliferation potential than the wild-type fibroblasts, which reached only a maximum of 46 doublings. However, the immortalized cells exhibited differences in the morphology compared with the control fibroblasts and transcriptome analysis also revealed changes in the gene expression patterns. Finally, the karyotypes of all hTERT-transgenic cell lines showed various aberrations such as presence of extra Chromosome 17, isochromosome 21q, or tetraploidy. By single-cell expansion of the least affected monoclonal immortalized line, one sub-clonal line with normal karyotype was established, suggesting the possibility to derive immortal marmoset cells with normal karyotypes. The results of this study are an important step towards the development and optimization of methods for the production of immortalized cells from common marmoset monkeys.
|
2022-12-29T14:58:45.179Z
|
235,778,179 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TCYB.2021.3089179",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this article, we study the reinforcement learning (RL) for vehicle routing problems (VRPs). Recent works have shown that attention-based RL models outperform recurrent neural network-based methods on these problems in terms of both effectiveness and efficiency. However, existing RL models simply aggregate node embeddings to generate the context embedding without taking into account the dynamic network structures, making them incapable of modeling the state transition and action selection dynamics. In this work, we develop a new attention-based RL model that provides enhanced node embeddings via batch normalization reordering and gate aggregation, as well as dynamic-aware context embedding through an attentive aggregation module on multiple relational structures. We conduct experiments on five types of VRPs: 1) travelling salesman problem (TSP); 2) capacitated VRP (CVRP); 3) split delivery VRP (SDVRP); 4) orienteering problem (OP); and 5) prize collecting TSP (PCTSP). The results show that our model not only outperforms the learning-based baselines but also solves the problems much faster than the traditional baselines. In addition, our model shows improved generalizability when being evaluated in large-scale problems, as well as problems with different data distributions.
|
2022-12-31T17:49:51.873Z
|
72,645,270 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1377/HLTHAFF.W3.511",
"MAG": "2091467728",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT: In this interview conducted by Jeff Goldsmith, former congressman and Speaker of the House Newt Gingrich (R-GA) provides an iconoclastic view of the problem of reforming a Medicare system...
|
2022-02-11T09:46:12.915Z
|
122,683,870 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/EL:19990358",
"MAG": "2157760976",
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},
"license": null,
"status": null,
"url": null
}
|
The problem of designing optimal templates for detecting image features is discussed. An equal area rule is derived which reduces the uncertainty involved when masks with a large number of free parameters have to be designed.
|
2022-02-09T19:02:08.146Z
|
226,793,967 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.34671/sch.hbr.2019.0304.0015",
"MAG": "3041301633",
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},
"license": null,
"status": "GOLD",
"url": "https://repository.kvantor.org/files/8c0be3f9-f36d-4d77-ab8e-50a10cdb2ad8"
}
|
UDC 330:657:658 DOI: 10.34671/SCH.HBR.2019.0304.0015 ПРИОРИТЕТНОСТЬ ВОПРОСОВ ЭКОНОМИЧЕСКОЙ БЕЗОПАСНОСТИ ТРУБОПРОКАТНЫХ ПРЕДПРИЯТИЙ © 2019 SPIN-код: 5045-7615 AuthorID: 709359 Малютина Татьяна Дмитриевна, кандидат экономических наук, доцент Волжский институт экономики, педагогики и прав (404111, Россия, Волжский, ул. Советская, 6, e-mail: shnaider-o@mail.ru) Аннотация. Российские трубопрокатные предприятия в современных сложных экономических условиях подвержены как локальным, так и внешним угрозам экономической безопасности. Задача нивелирования угроз экономической безопасности трубопрокатных предприятий в решении достаточна сложная и долгосрочная. Одной из причин по уровню сложности является их структурная принадлежность к предприятиям национальной безопасности, что расширяет задачи решения. Другая причина, определяющая высокий уровень сложности по обеспечению экономической безопасности трубопрокатных предприятий является их привлекательность промышленной разведки интересующейся их деятельностью. Безусловно, экономические отношения между предприятиями реального сектора, как на национальном, так и на мировом уровне обусловлены различными угрозами экономической безопасности, что обуславливает актуальность и значимость определения путей их минимизации и локализации. Как показывает практика сегодняшнего дня сложность и нестабильность мирового пространства определяет все новые направления угроз в части экономической безопасности для любого субъекта хозяйствования. Поиском и разработкой наиболее эффективных методов оценки уровня защищенности перед внешними и внутренними угрозами занимаются специалисты разного уровня, однако единого подхода и универсальной методологии пока не существует. Единое мнение специалистов по безопасности установлено в приоритетности факторов внешних угроз, так как экономические субъекты в большей степени не имеют рычагов влияния на них, в некоторых случаях их невозможно и предвидеть. Ключевые слова: задача нивелирования, внешние и внутренние угрозы, методология, национальная безопасность, практика, приоритетность, причины, реальный сектор экономики, система, субъект хозяйствования, трубопрокатные предприятия, экономическая безопасность, эффективные методы.
|
2022-06-02T23:44:52.521Z
|
241,217,574 |
{
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"ACL": null,
"ArXiv": null,
"DOI": "10.1515/9780691197463-006",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This chapter shows that there are some fundamental problems with contemporary democracy, especially the ideology beneath the one person, one vote system and the inevitable consequences of it. It identifies four problems of democracy: the suspicion of the elite, the neglect of the interests of nonvoters, the neglect of the interests of the minority, and the irrationality of voters. Then the chapter shows how the “internal” solutions are inadequate. Next, this chapter constructs a Confucian hybrid regime that is based on Mencius’s ideas discussed in Chapter 2, and shows how it can address the problems with democracy more adequately than present liberal democratic regimes. That is, the chapter reveals that the Mencian reservation of one person, one vote is actually a good thing about Confucianism.
|
2022-06-30T05:24:48.925Z
|
61,345,247 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1049/CJE.2015.04.026",
"MAG": "2280900576",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
This paper deals with the modeling, analysis, and measurement of a Small scale fading (SSF) mobile radio channel. The physics of SSF are first reviewed to reveal the generating mechanisms of channel selectivity. A stochastic channel model is then derived as a function of time, antenna array displacement and frequency, which falls in the category of tapped delay line model. Specifically, the taps can be represented as a combination of a possible line of sight or dominant reflected path and a Gaussian distributed component comprised of unresolvable scattered paths. After that, general analytical solutions are provided for the 3D temporal-spectral-spatial correlations of SSF via the exploitation of channel statistical properties. We show that this function can be expressed as the product of three low order temporal, spectral and spatial correlations individually under appropriate assumptions on the associated wireless propagation environment. This will definitely facilitate the derivations of the closed form expression regarding the correlation function of SSF. From engineering perspective, this analysis can be utilized to develop network correlation maps for example. Finally, out field measurement results verify the validity of our theoretical analysis.
|
2022-09-04T23:01:48.501Z
|
25,849,063 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1540-9740.2006.05019.X",
"MAG": "2001951020",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The clinical reaction pattern acute generalized exanthematous pustulosis is increasingly recognized today as drug intake details are more meticulously recorded and diagnostic guidelines are formulated. Nevertheless, the diagnosis and etiology remain unclear. This examination of the clinical and histologic features of acute generalized exanthematous pustulosis, undertaken in a retrospective study of 13 patients in an urban medical center, was aimed at determining the underlying mechanism of the etiology of the disease. Findings include a female predominance and the overwhelming prevalence of acetaminophen as the culprit agent, adding two more components to what is known about acute generalized exanthematous pustulosis. The possible mechanisms of the disease are discussed, enlightened by its appearance in two women in the study who were pregnant when the reaction first erupted.
|
2022-09-13T04:44:19.341Z
|
26,253,761 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISCAS.2013.6572293",
"MAG": "2070132960",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
In this study, we present a Carbon Nanotube (CNT) FET based 8T SRAM cell and its performance in near threshold voltage region. Metallic CNTs (M-CNTs) grow alongside semiconductor CNTs in current synthesis process, but they can be removed using novel techniques. This in turn creates open circuit and degrades the performance and functionality of SRAM cells. In this paper we apply a removed metallic CNT tolerant approach. The near threshold performance of the 8T SRAM cells with the tolerant approach is simulated and optimized to obtain best performance under the supply voltage from 0.4V to 0.9V. An evaluation of energy delay product and SNM shows a favorable tradeoff for the 0.6V power supply. The energy savings for cells with 0.6V power supply are 56.5% and 10.0% for average and worst case, respectively, compared with 0.9V; on the other hand, it has about 58% longer max delay and 25.8% lower static noise margin. The average and worst case values of EDP for 0.6V is 34.0% and 27.8% lower than that of 0.9V, with only 0.09% more invalid cell.
|
2022-12-18T09:16:49.992Z
|
37,218,014 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/02841850410005039",
"MAG": "2092853294",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Purpose: To measure the accuracy of laser‐guided punctures and to evaluate the usefulness of the developed laser‐guided system. Material and Methods: The study included 67 patients referred for computed‐tomography‐guided puncture. The majority of the punctured lesions were located in the chest (28 patients) or abdomen (19 patients). The mean diameter of the lesion was 3.1 cm, and the mean path length was 6.8 cm. The laser guide was movable along a horizontal or vertical rail and not physically connected to the CT unit. The angle of insertion was entered manually into the display of the unit by the interventional radiologist. A prospective multicenter trial was carried out. Results: A mean of 1.1 needle passes were necessary to reach the target, and in 55 (84.6%) of the patients the target was reached on the first needle pass. The mean deviation of the needle from the preselected angle was 1.8°. The mean targeting time (from the initial localizing scan until the needle was in the target) was 15.6 min. In every case, both the usefulness and the ease of use of the laser guidance system were subjectively evaluated on a 5‐point scale; the mean usefulness score was 4.5, while the mean ease of use score was 4.7. Conclusion: Different users at four different centers found the laser guidance system useful and easy to use. A high level of accuracy of the puncture angle was obtained in most cases.
|
2022-12-19T20:26:58.137Z
|
14,958,338 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/MCB.02429-06",
"MAG": "2165002886",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT Tumor necrosis factor alpha (TNF-α) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message turnover, message splicing, translation, and protein cleavage from the cell surface all being independently regulated. This study examined both cell lines and primary cells to understand the developmental regulation of epigenetic changes at the TNF-α locus. We demonstrate that epigenetic modifications of the TNF-α locus occur both developmentally and in response to acute stimulation and, importantly, that they actively regulate expression. DNA demethylates early in development, beginning with the hematopoietic stem cell. The TNF-α locus migrates from heterochromatin to euchromatin in a progressive fashion, reaching euchromatin slightly later in differentiation. Finally, histone modifications characteristic of a transcriptionally competent gene occur with myeloid differentiation and progress with differentiation. Additional histone modifications characteristic of active gene expression are acquired with stimulation. In each case, manipulation of these epigenetic variables altered the ability of the cell to express TNF-α. These studies demonstrate the importance of epigenetic regulation in the control of TNF-α expression. These findings may have relevance for inflammatory disorders in which TNF-α is overproduced.
|
2022-12-23T02:09:00.165Z
|
22,031,229 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3732/ajb.93.10.1546",
"MAG": "2110415881",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.3732/ajb.93.10.1546"
}
|
Fundamental plant traits such as support, anchorage, and protection against environmental stress depend substantially on biomechanical design. The costs, subsequent trade-offs, and effects on plant performance of mechanical traits are not well understood, but it appears that many of these traits have evolved in response to abiotic and biotic mechanical forces and resource deficits. The relationships between environmental stresses and mechanical traits can be specific and direct, as in responses to strong winds, with structural reinforcement related to plant survival. Some traits such as leaf toughness might provide protection from multiple forms of stress. In both cases, the adaptive value of mechanical traits may vary between habitats, so is best considered in the context of the broader growth environment, not just of the proximate stress. Plants can also show considerable phenotypic plasticity in mechanical traits, allowing adjustment to changing environments across a range of spatial and temporal scales. However, it is not always clear whether a mechanical property is adaptive or a consequence of the physiology associated with stress. Mechanical traits do not only affect plant survival; evidence suggests they have downstream effects on ecosystem organization and functioning (e.g., diversity, trophic relationships, and productivity), but these remain poorly explored.
|
2022-12-26T17:58:46.185Z
|
150,837,931 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1521/SISO.2019.83.2.244",
"MAG": "2921987395",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Aristotle’s account of natural slavery as presented in his Politics is often treated by historians of philosophy as an account that can be analyzed purely internally in terms of its argumentative structure without referring to social factors. Against this view, Aristotle’s account of natural slavery is seen to be ideological according to at least one variant of the Marxist concept of ideology, and cannot be understood without reference to Aristotle’s socioeconomic context. The ideological nature of Aristotle’s account of natural slavery is especially evident in his “proto-racialization” of the category of the “natural slave.” The Marxist concept of ideology is demonstrably useful in the historical study of philosophy, as compared with internalist historians of philosophy who claim that referring to nonphilosophical factors such as class interests inevitably obscures the philosophical content of the texts that are the objects of analysis.
|
2022-12-28T18:13:43.140Z
|
191,598,889 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5007/2175-7941.2014V31N3P677",
"MAG": "1994367136",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A reduced cost experimental procedure, in which the boiling point of water at room temperature is obtained, is presented. This procedure involves the introduction of water inside a fluorescent lamp discarded by techniques already described in the literature and included in this study. In addition to the observation of the room temperature boiling, the internal pressure of fluorescent lamps can be experimentally consistently obtained through the use of tap water previously boiled, which leads to the elimination of gaseous impurities dissolved therein; it is also suggested a technique to make more accurate the determination of the volume occupied by gases in the lamp. Steps to reduce to a minimum level of contamination when performing this procedure in a school environment are described.
|
2022-02-08T09:02:41.559Z
|
45,530,336 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/bmj.2.5256.877",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Oral leucoplakia was predominantly seen in elderly age group. Addiction to tobacco was observed in majority of patients (80.8%). Clinically commonest site of involvement was buccal mucosa (67.33%), followed by labial mucosa (13.86%). Majority of patients (57.35%) were having homogenous type of leucoplakia, followed by verrucous variety (25%). 26-48% cases were also having oral submucous fibrosis. Histologically various combinations of hyperkeratosis, hyperorthokeratosis and acanthosis were observed in 77.93% of cases. Dysplastic lesions were reported in 17.65% cases. In 80% of dysplastic lesions, band like infiltrate of mononuclear cells in subepithelial zone was seen. Malignant transformation was noticed in 2.94% cases. Excellent therapeutic results were obtained by cryosurgery. In resistant cases good results were observed with high dosage of vitamin A.
|
2022-07-09T06:02:23.850Z
|
120,493,973 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1086/153842",
"MAG": "1998516256",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://doi.org/10.1086/153842"
}
|
The coronal line Fe xiv 5303 A has been detected in Vela X at a statistical significance above zero of 6.3 sigma with a flux (3.9 +- 0.6) x 10$sup -12$ ergs (cm$sup 2$ s)$sup -1$ in a 1$sup 0$ diameter field. This demonstrates that the X-ray flux of Vela X is of thermal origin. The 3 sigma upper limits for the Fe xiv 5303 A and Ar xiv 4412 A coronal line fluxes from the supernova remnant Puppis A are respectively 4 x 10$sup -12$ and 2.6 x 10$sup -12$ ergs (cm$sup 2$ s)$sup -1$. (AIP)
|
2022-08-28T07:34:50.585Z
|
56,066,578 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17533/UDEA.LE.N85A06",
"MAG": "2949095331",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Este articulo examina empiricamente el grado de conocimiento y participacion de los ciudadanos de Barranquilla en el mercado bursatil colombiano. Para ello, se encuestaron 800 individuos distribuidos en las cinco localidades de la ciudad. Utilizando un modelo logit, se estimaron los factores que explican el estado del conocimiento del mercado bursatil asi como las variables que influyen en la probabilidad de inversion en la bolsa de valores. Se encuentra que el rango de ingresos determina en mayor medida el nivel de conocimiento e inversion en el mercado bursatil respecto al resto de variables. Finalmente, se confirma que se trata de un mercado de caracteristicas muy especificas, en el cual participan principalmente aquellos inversionistas con mayor conocimiento de las inversiones que ponen en marcha.
|
2022-09-10T12:57:33.056Z
|
761,581 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/j.1740-8261.2011.01829.x",
"MAG": "1547646674",
"PubMedCentral": "7169303"
},
"license": "implied-oa",
"status": "GREEN",
"url": "https://europepmc.org/articles/pmc7169303?pdf=render"
}
|
We characterized the pattern of ultrasonographic contrast enhancement of the small intestinal wall using a commercial contrast medium (Sonovue®) in 10 healthy awake cats. Subjectively, a rapid intense enhancement of the serosal and submucosal layers was followed by gradual enhancement of the entire wall section during the early phase. At peak enhancement, there was a subjective loss of demarcation between intestinal wall layers. In the late phase, there was a gradual wash out of signal from the intestinal wall. Submucosal wash out occurred last. Time‐intensity curves were generated for selected regions in the intestinal wall and multiple perfusion parameters were calculated for each cat. Perfusion parameters included arrival time (7.64 ± 2.23 s), baseline intensity (1.04 ± 0.04 a.u.), time to peak from injection (10.74 ± 2.08 s), time to peak from initial rise (3.1 ± 1.15), peak intensity (8.92 ± 3.72 a.u.), wash‐in rate (2.06 ± 0.70 a.u./s) and wash‐out rate (−1.07 ± 0.91 a.u./s). The perfusion pattern of normal feline small bowel may be useful for characterizing feline gastrointestinal disorders that involve the intestinal wall.
|
2022-10-21T01:30:12.481Z
|
86,259,924 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1071/BI9490166",
"MAG": "2210362946",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Nippostrongylus muris, Haemonchus contortus, Nematodirus spathiger, and N. filicollis are all capable of utilizing oxygen for respiratory purposes even when it is present at very low oxygen tensions. Thus with a partial pressure as low as 5 mm. of mercury the respiration of Nippostrongylus muris may reach 40 per cent. of its maximum rate, whereas Nematodirus spp. and H. contortus may respire at 25 and 12 per cent. of their maximum rates respectively. Further, the results indicate that in vivo the oxygen consumption rates may sometimes reach 80 per cent. of the maximum in vitro rate in the case of Nippostrongylus muris in the small intestine of the rat and 40 per cent. in the case of Nematodirus spp. in the small intestine of the sheep. Haemonchus contortus in the sheep abomasums probably respires at a relatively lower rate than either of the intestinal parasites in vivo.
|
2022-11-25T01:09:55.515Z
|
225,247,331 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/15528014.2020.1808429",
"MAG": "3083927328",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
ABSTRACT This article describes out method for “scaffolding expertise” that we used in our team-taught critical food studies course. We believe this technique allows students to not only gain knowledge about a particular food, but also models scholarly production of expertise on a small scale. It gives students an idea of what it means to be “experts” helping them to develop a more critical eye toward those who claim that title in other contexts.
|
2022-12-03T23:59:20.238Z
|
46,135,202 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/JOM.0000000000000459",
"MAG": "2415619761",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Objective: To test a model of presenteeism on the basis of established and emerging theories separated into organizational and individual factors that could be mediated by psychological distress. Methods: This was a Web survey of 2371 employees (response rate of 48%) of a provincial government agency. We assessed theories with validated measures for organizational and individual factors. Results: Psychological distress was negatively associated to presenteeism, when controlling for sex, short-term work absence in the last year, and social desirability. Both individual and organizational factors were related to psychological distress. The most important factors included the presence of stress events in the preceding 6 months, extrinsic efforts (interruptions, work requirements), self-esteem as a worker, and internal amotivation. Conclusions: By identifying modifiable factors, our results suggest that the implementation of a work organization structure that promotes stimulation and accomplishment would reduce psychological distress and further presenteeism.
|
2022-12-15T18:31:37.096Z
|
203,254,449 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17323/2499-9415-2019-2-18-81-106",
"MAG": "2971652680",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Рассмотрены термины, основные подходы и принципиальные схемы проведения оценки соответствия в двух формах: сертификации и декларирования. Проанализирована проблема обеспечения доверия к документам, подтверждающим безопасность продукции в условиях развития электронных форм торговли.
|
2022-01-27T01:39:19.421Z
|
143,550,628 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3166/RIGE.11.455-486",
"MAG": "2016914103",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Dans le contexte des reseaux du futur integrant de la production decentralisee a haut taux d'energie renouvelable ainsi que des nouvelles technologies d'information et communication, on peut envisager que les charges ne seront plus « passives » au sein du reseau, mais prendront une part active et concrete au bon fonctionnement des systemes electriques, et pourront ainsi contribuer a des services aux reseaux de transport et de distribution, et aux services systeme. L'etude bibliographique presentee dans cet article doit permettre de comprendre la problematique du pilotage de charges, necessaire a la contribution de services, en analysant plusieurs questions et problemes relatifs a la mise en place d'un pilotage actif. Cet article expose les besoins necessaires au controle de charges, propose un classement des charges suivant leur type, et la facon de les piloter. Enfin le controle de charge d'un point de vue conceptuel est aborde. Il faut noter qu'un etat de l'art sur l'existant concernant le pilotage de charges existe, mais que pour des raisons evidentes de place, il n 'est pas expose ici.
|
2022-02-09T07:26:38.648Z
|
143,119,381 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1086/442453",
"MAG": "1966750155",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A disconcerting fact has been abroad for some time. Many of our most able high-school graduates are not going on to college. For every qualified high-school graduate in the top quarter of his class who does go to college, another equally qualified graduate ends his formal education in high school (3). It is not hard to understand why this fact is disconcerting. Higher education, we know, is a training ground. College graduates find their way to positions in business, government, industry, science, and the professions. The well-being of society is best served when the men and women in these posts have the highest personal and professional qualifications available. When capable students lack preparation for such responsible posts, society is denied the services of talented members in positions where talent deserves high priority. This loss robs the professions and vocations of valuable recruits, but far from ending here, the loss extends to our civic life, for higher education can enrich this realm too. The liberal arts studies of col-
|
2022-02-09T07:39:39.521Z
|
73,060,614 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1108/20428301311330144",
"MAG": "2107036114",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Purpose – The purpose of this paper is to argue that monitoring of symptoms through self‐assessed data is not only a vital part of record taking in mental health care, but can also aid patients in their recovery, giving them more of a say in their healthcare, and providing a record of progress for both patients and clinicians.Design/methodology/approach – A literature search was undertaken to identify ways in which self‐assessed data is used in mental health care and to examine how successful this approach may be in aiding recovery and whether patients are able and enthusiastic to participate in this approach. Ideas for effective approaches to utilising self‐assessed data into mental health care are suggested.Findings – There were clear indications from the literature that the use of self‐assessed data improves health outcomes and that patients enjoy the process. This approach promotes greater inclusion of individuals in the management of their health care.Practical implications – Self‐assessed data can b...
|
2022-03-06T04:09:37.296Z
|
249,350,709 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14712/23363398.2022.2",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://karolinum.cz/data/clanek/10222/Theol_11_2_0011.pdf"
}
|
Bonaventure’s epistemology is partly based on his Trinitarian theology. This paper investigates the Trinitarian connotations in this epistemology and their broader significance. Like the divine Father, any object of human understanding is liberally generating a likeness of itself: the species. Apprehending the form of the object through this species is an essential feature of human knowledge for Bonaventure. More fundamentally, the human soul itself is structured according to the Augustinian Triad of memoria, intellectus and voluntas, and the transcendentals of being correspond to the human soul’s structure: unum, verum and bonum. Both the human being and the transcendentals of being originate ultimately from the Trinitarian life or actuality, which is a self-relation in truth and love: The Father generates a Word and both together spirate the nexus between Father and Son: the Holy Spirit. Bonaventure’s notion of Trinitarian actuality as it is imaged in the human and being itself can help deepen Aquinas’ metaphysical notion of created esse as the actuality of all acts: An enriched notion of Trinitarian actuality necessarily involves, just as Hugo of St. Victor’s notion of love, a life of personal self-communication and reception, in the context of which the speech of divine ‘suffering’ makes sense, and does not involve mutability. Understanding Trinitarian actuality as the life of love exemplary for creation might open up vistas for a mutual fertilization between Thomistic metaphysics and Bonaventure’s Trinitarian theology, so as to further the development of a Trinitarian ontology without confusing the distinction between Philosophy and Theology.
|
2022-06-18T09:59:43.228Z
|
235,707,988 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/s21134500",
"MAG": null,
"PubMedCentral": "8271378"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1424-8220/21/13/4500/pdf?version=1625134054"
}
|
In the context of real-time control systems, it has become possible to obtain temporal resolutions of microseconds due to the development of embedded systems and the Internet of Things (IoT), the optimization of the use of processor hardware, and the improvement of architectures and real-time operating systems (RTOSs). All of these factors, together with current technological developments, have led to efficient central processing unit (CPU) time usage, guaranteeing both the predictability of thread execution and the satisfaction of the timing constraints required by real-time systems (RTSs). This is mainly due to time sharing in embedded RTSs and the pseudo-parallel execution of tasks in single-processor and multi-processor systems. The non-deterministic behavior triggered by asynchronous external interrupts and events in general is due to the fact that, for most commercial RTOSs, the execution of the same instruction ends in a variable number of cycles, primarily due to hazards. The software implementation of RTOS-specific mechanisms may lead to significant delays that can affect deadline requirements for some RTSs. The main objective of this paper was the design and deployment of innovative solutions to improve the performance of RTOSs by implementing their functions in hardware. The obtained architectures are intended to provide feasible scheduling, even if the total CPU utilization is close to the maximum limit. The contributions made by the authors will be followed by the validation of a high-performing microarchitecture, which is expected to allow a thread context switching time and event response time of only one clock cycle each. The main purpose of the research presented in this paper is to improve these factors of RTSs, as well as the implementation of the hardware structure used for the static and dynamic scheduling of tasks, for RTOS mechanisms specific to resource sharing and intertask communication.
|
2022-12-02T11:22:23.451Z
|
186,171,836 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.23996/FJHW.60989",
"MAG": "2619413326",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Nakemys sosiaalihuollon keskeisesta tietopaaomasta tulee luoda yhdessa sosiaalihuollon asiantuntijoiden kanssa. Sosiaalihuollon asiakastietomallia, joka perustuu sosiaalihuollon ammattilaisten kuvaamiin tietotarpeisiin, kehitetaan osana sosiaalihuollon valtakunnallisten tietojarjestelmapalvelujen ja maaramuotoisen kirjaamisen toimeenpanohanketta (Kansa-hanke). Vuosina 2013–2015 sosiaalihuollon ammattilaiset katselmoivat kaikki sosiaalihuollon asiakastietomalliin sisaltyvat asiakasasiakirjarakenteet. Katselmointiin osallistuneet sosiaalihuollon ammattilaiset olivat eri puolilta Suomea ja he kayttivat erilaisia tietojarjestelmia. Katselmoijat arvioivat asiakasasiakirjarakenteiden riittavyytta ja tarpeellisuutta. Asiakirjarakenteen yksittaisten tietojen osalta arviointikriteereita olivat muun muassa tiedon tarpeellisuus, tiedon sijainti oikeassa asiakirjassa tai oikeassa kohdassa asiakirjaa seka tiedon esitysmuodon oikeellisuus. Asiakirjarakenteet kerasivat yli 2000 kommenttia, ja eniten kommentoitiin asiakastyon kannalta keskeisia, sisalloltaan laajoja asiakirjarakenteita kuten palvelutarpeen arvioita ja suunnitelmia. Artikkelissa esitetyt tulokset perustuvat paaasiassa konsultin tekemaan tulosten tiivistelmataulukkoon, joka oli laadittu tulosten yhteenvetoa ja esittelya varten. Saadun katselmointipalautteen perusteella asiakastietomallista poistettiin useita asiakirjarakenteita, esimerkiksi asiakirjarakenteita, joiden tarkoituksena oli arvioida suunnitelmien toteutumista. Katselmointipalautteen perusteella myos vahennettiin useiden asiakirjojen rakenteisuutta, lisattiin mahdollisuutta narratiiviseen dokumentointiin ja tehtiin myos monia muita pienempia korjauksia ja muutoksia. Systemaattinen palautteen keraaminen ja sen kasittely on tehokas keino asiakirjarakenteiden laadun varmistamiseksi ja parantamiseksi. Haasteita tulosten tulkintaan ja konsensuksen loytamiseen tuo se, etta ammattilaisten toimintaymparisto, kaytossa oleva asiakastietojarjestelma seka totuttu kirjaamistapa vaikuttavat nakemyksiin siita, millaisia asiakirjarakenteiden tulisi olla ja millaisia tietoja asiakastyossa tarvitaan. Mahdollisimman selkea esitysmuoto katselmoitaville tietorakenteille, esimerkiksi asiakastietojarjestelmaa jaljittelevan kayttoliittyman avulla, parantaisi tietorakenteiden ymmarrettavyytta ja niista annetun palautteen laatua. Paitsi tietorakenteita myos tietojarjestelmien kaytettavyytta ja muita ominaisuuksia tulisi kehittaa yhdessa sosiaalihuollon ammattilaisten kanssa.
|
2022-12-10T09:04:18.521Z
|
24,033,856 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1371/journal.pone.0147313",
"MAG": "2297203620",
"PubMedCentral": "4720401"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0147313&type=printable"
}
|
In this study, we applied the text-change paradigm to investigate whether and how discourse hierarchy affected the memory representation of a discourse. Three kinds of three-sentence discourses were constructed. In the hierarchy-high condition and the hierarchy-low condition, the three sentences of the discourses were hierarchically organized and the last sentence of each discourse was located at the high level and the low level of the discourse hierarchy, respectively. In the linear condition, the three sentences of the discourses were linearly organized. Critical words were always located at the last sentence of the discourses. These discourses were successively presented twice and the critical words were changed to semantically related words in the second presentation. The results showed that during the early processing stage, the critical words were read for longer times when they were changed in the hierarchy-high and the linear conditions, but not in the hierarchy-low condition. During the late processing stage, the changed-critical words were again found to induce longer reading times only when they were in the hierarchy-high condition. These results suggest that words in a discourse have better memory representation when they are located at the higher rather than at the lower level of the discourse hierarchy. Global discourse hierarchy is established as an important factor in constructing the mental representation of a discourse.
|
2022-12-10T21:49:13.557Z
|
212,890,154 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/en13040929",
"MAG": "3007804654",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1996-1073/13/4/929/pdf?version=1582881958"
}
|
This paper concerns the optimal design and comparative analysis of resonant and non-resonant high-frequency GaN-based rotating transformers. A multi-physical design approach is employed, in which magnetic, electrical, and thermal models are coupled. The results are verified by experiments. Two different optimization objectives are considered; firstly, the efficiency of two standard core geometries is maximized for a required output power level. Secondly, a geometrical optimization is performed, such that the core inertia is minimized for the desired output power level. The results of both design optimizations have shown large improvements in terms of output power and core inertia as a result of applying series–series resonant compensation.
|
2022-12-02T10:36:20.495Z
|
78,620,838 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/030006059702500203",
"MAG": "2494278441",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The role of transforming growth factor-β1 (TGF-β1) in human glomerulonephritis is still poorly understood. The relationship between expression of TGF-β1 protein or TGF-β1 mRNA and tissue damage was investigated using the enzyme–antibody and in situ hybridization method in frozen slices of renal tissue from 30 patients: 25 with glomerulonephritis (18 with immunoglobulin A nephropathy; two with focal glomerulosclerosis, one with membranous nephropathy, one with crescentic glomerulonephritis and three with lupus nephritis) and five control patients with minimal change disease. The expression of TGF-β1 mRNA was high in sclerotic and proliferative glomeruli, as well as in the tubular epithelial cells within tubulointerstitial lesions. There was significant correlation between the severity of tissue damage in immunoglobulin A nephropathy and the presence of TGF-β1protein and TGF-β1 mRNA. These findings suggest that TGF-β1 is involved in glomerulosclerosis and the development of tubulointerstitial lesions, indicating its potential importance in the progression and aggravation of immunoglobulin A nephropathy.
|
2022-12-14T12:50:36.590Z
|
198,872,345 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.31921/DOXACOM.N28A09",
"MAG": "2953563340",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Este monográfico propone una reflexión sobre las complejas relaciones entre los jóvenes y los adolescentes con la tecnología, aportando nuevas ideas fruto de la investigación científica en este campo, y ofreciendo nuevas aproximaciones a tan compleja realidad social
|
2022-12-15T11:20:40.330Z
|
205,274,578 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1073/pnas.1509930112",
"MAG": "1717419206",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.pnas.org/content/pnas/112/28/8714.full.pdf"
}
|
Significance Fibroblast growth factor 21 (FGF21), a hormone that mediates an adaptive response to starvation, is also a long-standing marker of mitochondrial disease. In this article, we describe the metabolic benefits induced by mild mitochondrial stress via FGF21 induction in polymerase gamma mtDNA mutator (POLG) mice, a model of mitochondrial disease and premature aging. When challenged with a high-fat diet (HFD), these mice resist diet-induced obesity and its underlying associated disease states. In addition, nutrients from a HFD appear to reverse metabolic imbalance in these mice. HFD also robustly increases fat metabolism and improves mitochondrial function in brown fat, which mediates adaptive thermogenesis. Hence, we highlight a metabolically favorable synergy between mitochondrial stress and HFD facilitated by FGF21 in this mouse. Mitochondria are highly adaptable organelles that can facilitate communication between tissues to meet the energetic demands of the organism. However, the mechanisms by which mitochondria can nonautonomously relay stress signals remain poorly understood. Here we report that mitochondrial mutations in the young, preprogeroid polymerase gamma mutator (POLG) mouse produce a metabolic state of starvation. As a result, these mice exhibit signs of metabolic imbalance including thermogenic defects in brown adipose tissue (BAT). An unexpected benefit of this adaptive response is the complete resistance to diet-induced obesity when POLG mice are placed on a high-fat diet (HFD). Paradoxically, HFD further increases oxygen consumption in part by inducing thermogenesis and mitochondrial biogenesis in BAT along with enhanced expression of fibroblast growth factor 21 (FGF21). Collectively, these findings identify a mechanistic link between FGF21, a long-known marker of mitochondrial disease, and systemic metabolic adaptation in response to mitochondrial stress.
|
2022-12-18T17:02:52.726Z
|
207,887,877 |
{
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"ArXiv": null,
"DOI": "10.1098/rsbl.2019.0447",
"MAG": "2986789419",
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},
"license": null,
"status": "BRONZE",
"url": "https://royalsocietypublishing.org/doi/pdf/10.1098/rsbl.2019.0447"
}
|
Natural and human disturbances have caused widespread regime shifts in shallow lakes of the lower Yangtze basin (LYB, China) resulting in a severe decline of ecosystem services. Improved understanding of the relationship between environmental forcing and ecosystem response, and the mechanisms behind regime shifts has significant implications for management. However, the patterns of these regime shifts and the underlying internal mechanisms are less known. In this study, two typical lakes (Chaohu and Zhangdu) from the LYB were selected to determine the trajectories of ecological regime shifts, both of which transitioned from vegetation- to plankton-dominated states several decades ago. Ecological trajectories since the 1900s in both lakes were reconstructed using palaeolimnological proxies, mainly diatom assemblages. Although results show that regime shifts occurred in both lakes in the 1970s and the 1950s, respectively, their inherent mechanisms were different. In Lake Zhangdu, altered hydrological conditions pushed the ecosystem across an ecological threshold, providing an example of a driver-mediated regime shift. In Lake Chaohu, ongoing nutrient loading influenced ecosystem processes and drove the lake to an alternative stable state, potentially presenting an example of a critical transition after a loss of resilience. This research indicates that palaeolimnological perspectives can provide insights into regime shift changes, as well as important information regarding which restoration methods should be tailored to individual lakes.
|
2022-12-20T13:51:13.029Z
|
244,614,696 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1075/langct.20003.mar",
"MAG": "3206804136",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
J. R. Martin is a leading scholar who has greatly developed the theoretical framework of systemic functional
linguistics (SFL) over the past four decades. Some of these contributions, such as the systems of discourse semantics, the
appraisal framework and genre relations have been widely applied in various areas of linguistic studies and language education.
The educational linguistic model he and his colleagues have cultivated and developed has attracted the attention of more and more
educators from different disciplines around the globe. In this interview, he firstly elaborates on the significance of the
concepts of discourse semantics, grammatical metaphor and genre. Then he continues with applications of genre theory in secondary
school education, language maintenance, the relation and collaboration between Legitimation Code Theory (LCT) and SFL, and how the
two paradigms complement each other. Finally, he introduces some of his recent collaborations with grammarians of different
languages.
|
2022-02-07T20:06:10.760Z
|
53,967,359 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17706/IJCEE.2016.8.1.57-65",
"MAG": "2329299078",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The physical parameter for the so-called Biologically Active Points most documented in the literature is the electrical impedance. These points seem to have higher electrical conductance than their surrounding points. The stimulation of these points is made not only mechanically and electrically but also optically (laser acupuncture) and thermically (moxibustion). We evaluated by optoacoustic technique and by photothermal radiometry, some skin points along the PC acupuncture meridian in the forearm region. We found a slight relative increment in absorption in some regions around the meridian region but without a definite association with an acupoint. Moreover, the same case can be applied to a non-meridian line. In radiometric signals we did not find differences with respect to control points in a two layer model. Based in these results we can not conclude that such points are optically or thermally special.
|
2022-02-11T21:18:12.876Z
|
248,352,641 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.30972/vet.3315883",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://revistas.unne.edu.ar/index.php/vet/article/download/5883/5557"
}
|
La cría de llamas es una importante actividad de impacto socioeconómico en la región Puna de la Provincia de Jujuy, sin embargo, la misma tiene una baja tasa de procreo. Con el objetivo de estudiar potenciales causas de pérdidas reproductivas y perinatales, se controló una tropa nativa de llamas durante toda la etapa gestacional y se establecieron los índices de preñez, abortos, natimortos, teratogenia y muerte perinatal. Además, se realizaron estudios serológicos de brucelosis, leptospirosis, diarrea viral bovina, herpes virus bovino, neosporosis, sarcocystosis y toxoplasmosis en las hembras que presentaron pérdidas de gestación. El 82,8% (24/29) de las pérdidas reproductivas no pudieron asociarse a la infección con los agentes virales y bacterianos investigados. Los niveles de anticuerpos contra N. caninum, T. gondii y diferentes serovares de Leptospira sp podrían sugerir infecciones crónicas con baja relación con las pérdidas reproductivas detectadas. Astragalus garbancillo fue identificado entre la vegetación de pastoreo, y su consumo podría estar asociado a la presentación de crías con deformaciones y posiblemente abortos y mortalidad de crías débiles, siendo que los animales con mayor exposición a su consumo, tuvieron más de 4 veces mayor riesgo de padecer pérdidas peri-post-natales que los menos expuestos. Se requieren mayores estudios para establecer la asociación de estas potenciales causas con las pérdidas reproductivas, principalmente abortos y teratogenia en llamas.
|
2022-05-09T11:49:50.711Z
|
109,507,745 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/J.1538-7305.1970.TB01837.X",
"MAG": "1978446493",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The new Bell System battery has been designed to eliminate the problems experienced in applying the old cells. This article tells how the new cell will be incorporated into the telephone plant and describes a new plastic battery rack which has been specifically designed to accommodate the new cell in an optimum manner.
|
2022-08-24T21:44:16.376Z
|
144,500,243 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7202/305650AR",
"MAG": "2073841887",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Cet article analyse le mode de constitution de l'histoire culturelle au Quebec comme domaine historiographique en montrant comment s'est conceptualisee cette appellation et comment elle a developpe des outils methodologiques. L'etude explore les relations entre l'histoire culturelle et d'autres domaines de l'historiographie (histoire de la litterature, de la religion, de la politique, des arts et l'ethnologie) ainsi que ses rapports a des questions debattues de l'historiographie (« revisionnisme », liberalisme, fascisme). L'article situe enfin l'histoire culturelle pratiquee au Quebec dans l'historiographie internationale.
|
2022-09-09T04:21:34.015Z
|
59,432,312 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2018/6292410",
"MAG": "2887645288",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://downloads.hindawi.com/journals/jat/2018/6292410.pdf"
}
|
Flexible transit services, which bring together the characteristics of fixed-route transit and demand-responsive transit, have been proven to be cost-efficient in low-density residential areas. In this paper, a methodology is proposed to assist planners in making better decisions when choosing between route deviation policy and point deviation policy, which are two promising types of flexible transit services. A user cost function is developed to measure the service quality of the transit systems, and analytical models are constructed to compare the system performance under both expected and unexpected demand levels. Based on the experiments for various scenarios over a real-life transit example, the critical demands, which represent the switching point between the two competing service policies, have been derived. Our findings show that point deviation policy is more efficient at low-demand levels, while route deviation policy is a better choice at low-to-moderate demand levels. At unexpectedly high demand levels, route deviation policy is better able to accommodate rejected passengers than point deviation policy.
|
2022-12-16T05:07:44.747Z
|
72,667,927 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/ARCHOTOL.1990.01870020021001",
"MAG": "2059329762",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
On June 27, 1989, at the Fifth International Symposium of Plastic and Reconstructive Surgery of the Head and Neck in Toronto, Canada, Peter Costantino, MD, and Craig Friedman, MD, Chicago, Ill, presented the results of their research using a new form of hydroxyapatite in laboratory animals. A hydroxyapatite putty, whose key component is tetracalcium phosphate (Ca 4 (PO 4 ) 2 ), was studied in three experimental models using cats. Initially, solid disks of the putty were implanted intramuscularly to study the soft-tissue response. The material was well-tolerated, demonstrating no fibrous encapsulation and only minimal resorption. The hydroxyapatite putty was then used to obliterate and contour frontal sinuses, and also to fill cranial bone defects that extended to the level of the dura. There were no infections, extrusions, structural failures, or toxic reactions noted in either group. Serial histologic examinations between 6 and 18 months revealed progressive replacement of the implanted material by
|
2022-02-11T09:44:29.699Z
|
130,271,571 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5937/BIZINFO1402001B",
"MAG": "2344377496",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Regarding the health, ethical and social aspects mobile phones pose risk for preschool and school-age children. It is necessary to point out the risks in the use of mobile phones by children under the age of 10 years. For this reason, it is necessary to consider some important aspects of mobile phone use by children, such as age and number of children who use mobile phones, access the Internet through mobile phones, knowledge of information security when using mobile phones, and so on. This paper presents the results of research conducted on a sample of 50 parents of preschool and school-age children related to previously stated aspects. An electronic questionnaire was used as an instrument for the collection of appropriate data needed for the study. At the end of the paper there are proposals for reduction of existing risks in order to protect the health and safety of children.
|
2022-08-26T14:01:52.240Z
|
122,706,425 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1142/S0578563405001173",
"MAG": "2158463676",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Wave impact on one and two structural beams with rectangular cross section is simulated with a two-dimensional finite volume method, solving the unsteady Euler equations and employing a VOF-type method for the description of the free surface. Four different test series are carried out, each corresponding to a wave impact scenario in the experimental database of Sterndorff [2002]. For the case of wave impact on a single structural element the numerical results show good agreement, with measured force time histories. In the computations featuring two beams, the prediction of the shadowing effect of the first beam on the second is in reasonable agreement with the experimental data. However, the force peak on the second beam is somewhat over-predicted. The calculations successfully predict a second peak in the force time series of the second beam, which is caused by airborne water shipped over the first beam. Throughout the work, spurious spikes of very short duration appear in the computed load time series, originating from the changing of the flow separation location along the lower edge of the beams.
|
2022-09-04T08:51:53.148Z
|
123,143,993 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1742-5468/2009/03/P03027",
"MAG": "2067383568",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
We analyze in this work how the existence of macrostates with negative heat capacities can be accounted for in terms of the thermodynamic stability and the fluctuation-dissipation relation associated with an open system in thermodynamic equilibrium. As a by-product of this reasoning, we also provide new arguments concerning the existence of a complementary character between energy and temperature rather analogous to the one existing in quantum mechanics between position and momentum.
|
2022-10-08T06:12:29.363Z
|
146,643,493 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0260210500112562",
"MAG": "2156715500",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
On 22 June 1946 the Government of India asked that the treatment of Indians in South Africa be placed on the agenda of the Second Part of the First UN General Assembly. This was the first dispute to be taken to the General Assembly and it resulted in the UN's first attack on South Africa. From the perspective of the 1990s the only striking thing about the 1946 UN resolution is its mild tone and the limitation of its criticism to South Africa's, policies relating to just one group. However, from the perspective of 1946 it is remarkable that the UN should even have discussed South Africa's treatment of her Indian citizens, let alone have decided by a two-thirds majority that she had failed to treat them in conformity with. her international obligations and the relevant provisions of the UN Charter.
|
2022-12-14T18:13:40.919Z
|
234,478,436 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/I2CT51068.2021.9417943",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
For the discrete-time control system represented in state-space form, a three-term controller has been designed based on three successive sampled values of output for the optimal control of the system. It is of much reduced order as there is no necessity of having complete state feedback. Limitation, however, is that ideally number of outputs must be half of number of states of the system. Otherwise, it calls for pseudo-inverse of a matrix. In such case control achieved of course will be a sub-optimal one.
|
2022-01-23T03:01:59.961Z
|
94,327,030 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.47640",
"MAG": "1558232231",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
A specially designed planar magnetron for direct atomization of solid materials by ion sputtering was investigated. The atomizer provides much higher atom flux than a previously used hollow‐cathode type. The potentialities of the atomizer were examined by the analysis of Si traces in high‐purity In and Ga. Theoretically simulated calibration curves for a particular geometry of the atomizer were compared with the experimentally obtained ones. For both matrices the deviations of the experimental and simulated calibration curves were less than a factor of three. Limits of detection (3 σ) of 0.8 ng/g for In and of 2 ng/g for Ga were obtained.
|
2022-02-10T16:21:12.798Z
|
25,380,014 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/(SICI)1097-0185(19990801)255:4<465::AID-AR12>3.0.CO;2-Z",
"MAG": "2019086658",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
The branching patterns of nerves supplying the intrinsic muscles of the foot were analyzed as a basis to confirm the muscle layer structure. Thirty‐eight feet of 20 Japanese cadavers were examined in detail in this study.
|
2022-02-12T18:12:40.512Z
|
127,685,559 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.21000/JASMR90010535",
"MAG": "1485197785",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Fires in abandoned coal mines and waste banks present serious safety and environmental hazards. Often, spontaneous combustion is assumed to be the source of these fires, although some coals have an apparently low susceptibility to self‐heating. It has also been noted that in abandoned mines evidence of heating is found in the roof coal and shale. Spontaneous ignition is also a factor in coal waste bank fires. Although the spontaneous combustion of coal has been studied extensively, there is very little information about the self‐heating tendency of roof coals and carbonaceous shales. This study of self‐heating tendencies utilized a modified version of a differential thermal analyzer. In this study, a combustion furnace served as the reference temperature against which the sample temperature was measured. A crossing point temperature index was used to relate self‐heating tendencies of various samples. Analysis of the effluent gas for CO2, CO, O2 depletion and desorbed hydrocarbons was also used to evaluate the degree of self‐heating and the heat generating process. Average sample size was 3 kg; particle size was between ‐1/4 in and +20 mesh. Furnace temperature was between 20 and 2000 C. The air flow rate was 2 scfh, and each sample was heated in moist and dry air. Ten samples, including the Pittsburgh coal, roof slate, carbonaceous shales and western coals were tested. The crossing point index was compared to known self‐heating behavior, reaction rates, BTU values and compositional differences. Additional key words: Spontaneous combustion, Abandoned mine fires, Waste bank fires. 1 Paper presented at the 1990 Mining and Reclamation Conference and Exhibition, Charleston, West Virginia, April 23‐26, 1990. 2 Ann G. Kin is Research Chemist and Robert F. Chaiken is Supervisory Research Chemist at Pittsburgh Research Center, U.S. Bureau of Mines, Pittsburgh, PA 15236.
|
2022-03-06T10:36:52.503Z
|
203,069,403 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/en12183446",
"MAG": "2971714039",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/1996-1073/12/18/3446/pdf?version=1567767365"
}
|
The increasing demand for renewable and sustainable energy sources has encouraged the development of small run-of-river plants. Preliminary studies are required to assess the technical and economic feasibility of such plants. In this context, the identification of optimal potential run-of-river sites has become a key issue. In this paper, an approach that is based on GIS tools coupled with a hydrological model has been applied to detect potential locations for a run-of-river plant. A great number of locations has been analyzed to identify those that could assure the achievement of different thresholds of potential power. The environmental and economic feasibility for small hydropower projects in these locations has been assessed and a multi-objective analysis has been carried out to highlight the most profitable configurations. The Soil and Water Assessment Tool (SWAT) has been calibrated to simulate runoff in the Taw at Umberleigh catchment (South West England). The results showed that, in the area of study, different locations could be selected as suitable for run-of-river plants.
|
2022-12-16T12:42:50.831Z
|
172,061,021 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.30783/NEVSOSBILEN.357554",
"MAG": "2881927805",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
}
|
Gunumuzde ortalama insan omrunun gecmis yillara gore daha uzun olmasi ve bununla birlikte bilgi kaynaklarindaki hizli artis insanlarin surekli yeni seyler ogrenmesini zorunlu hale getirmektedir. Yuksekogrenim kurumlari sayisindaki nicel artislar sonucu universite ogrenimi goren ogrenci sayisi da es zamanli olarak artmaktadir. Bununla birlikte basta teknolojik gelismeler ve iletisim imkanlarinda yasanan hizli degisimlere ragmen ogrenim gorenlerin, ogrenme duzeylerinde benzer oranda bir artisin gorulememesi toplumda genel kabul goren onemli bir durum haline gelmektedir. Soz konusu hedef kitlenin universite duzeyinde ogrenim goren kisilerin olmasi ise olayin onemini daha da artirmaktadir. Bu calismada universitede ogrenim goren ogrencilerin “yasam boyu ogrenme” egilimleri olculerek, yeni bilgilere ulasmaya ne kadar istekli, merakli ve motive olduklarinin ortaya konulmasi amaclanmistir. Bu amac dogrultusunda, Usak Universitesi Esme Myo’da farkli programlarda ogrenim goren ogrencilere, gecerliligi ve guvenirligi test edilmis altili likert dereceleme turunde hazirlanan “yasam boyu ogrenme egilimlerini belirleme olcegi” kullanilarak, demografik ozellikleri de kapsayan bir olcekten yararlanilmaktadir. Arastirma sonucu elde edilen veriler icin gerekli analizler yapilarak universite ogrencilerinin yasam boyu ogrenme duzeyleri tespit edilmistir. Buna gore universiteye girisin sinavli veya sinavsiz olmasi buyuk onem tasimakta oldugu, cinsiyete ve sinif duzeylerine gore onemli farkliliklarin oldugu ortaya cikmistir.
|
2022-06-25T18:54:05.343Z
|
16,280,131 |
{
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CVPRW.2010.5543751",
"MAG": "2152619902",
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},
"license": null,
"status": null,
"url": null
}
|
This paper introduces our research platform for enabling a multimodal Human-Robot Interaction scenario as well as our research vision: approaching problems in a holistic way to realize this scenario. However, in this paper the main focus is laid on the image processing domain, where our vision has been realized by combining particle tracking and Dynamic Bayesian Network classification in a unified Graphical Model. This combination allows for enhancing the tracking process by an adaptive motion model realized via a Dynamic Bayesian Network modeling several motion classes. The Graphical Model provides a direct integration of the classification step in the tracking process. First promising results show the potential of the approach.
|
2022-08-28T11:19:56.611Z
|