text
stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the minimum inhibitory concentrations ( mics ) of tobramycin , gentamicin , sisomicin , and amikacin were determined for these organisms .
|
NA
|
{
"id": "C0017436",
"name": "gentamicin",
"pos": [
63,
73
]
}
|
{
"id": "C0037209",
"name": "sisomicin",
"pos": [
76,
85
]
}
|
metallic copper in the incubation medium caused the same qualitative effects on the smooth muscle preparation as cucl2 .
|
NA
|
{
"id": "C0009968",
"name": "copper",
"pos": [
9,
15
]
}
|
{
"id": "C0056593",
"name": "cucl2",
"pos": [
113,
118
]
}
|
we treated one eye each of ten patients with ocular hypertension with dipivalyl epinephrine ( dpe ) , a congener of epinephrine .
|
NA
|
{
"id": "C0058415",
"name": "dipivalyl",
"pos": [
70,
79
]
}
|
{
"id": "C0014563",
"name": "epinephrine",
"pos": [
116,
127
]
}
|
although the level of serum betalipoprotein might be correlated with retinal pigmentary degeneration in familial hypobetalipoproteinemia and abetalipoproteinemia , it appears that neurologic and cardiac defects are dependent on other factors .
|
NA
|
{
"id": "C0020597",
"name": "familial hypobetalipoproteinemia",
"pos": [
104,
136
]
}
|
{
"id": "C0000744",
"name": "abetalipoproteinemia",
"pos": [
141,
161
]
}
|
direct intracoronary injections of isoproterenol , norepinephrine , and epinephrine gave results consistent with the presence of beta-1 myocardial receptors and alpha and beta-2 coronary receptors .
|
NA
|
{
"id": "C0028351",
"name": "norepinephrine",
"pos": [
51,
65
]
}
|
{
"id": "C0014563",
"name": "epinephrine",
"pos": [
72,
83
]
}
|
intracoronary injections of isoproterenol and epinephrine activated beta-2-receptor coronary vasodilation after beta-1-receptor blockade , but norepinephrine did not .
|
NA
|
{
"id": "C0014563",
"name": "epinephrine",
"pos": [
46,
57
]
}
|
{
"id": "C0028351",
"name": "norepinephrine",
"pos": [
143,
157
]
}
|
the proteins included mouse igf and igm , mouse , bovine , rabbit , and human igg , human serum and salivary iga , human transferrin and albumin , and mouse and human immunoglobin light chains .
|
NA
|
{
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
}
|
{
"id": "C0001924",
"name": "albumin",
"pos": [
137,
144
]
}
|
human iga without secretory piece was transported into milk more rapidly than iga with secretory piece attached .
|
NA
|
{
"id": "C0036538",
"name": "secretory piece",
"pos": [
18,
33
]
}
|
{
"id": "C0020838",
"name": "iga",
"pos": [
78,
81
]
}
|
prostaglandin e ( pgs ) is synthesized and released in isolated canine trachealis muscle ( ctm ) , and the pge threshold concentration for an effect on isometric tension is very low , indicating this prostaglandin is a most likely candidate for an endogenous prostaglandin that modulates or regulates tension .
|
NA
|
{
"id": "C0033559",
"name": "pge",
"pos": [
107,
110
]
}
|
{
"id": "C0033554",
"name": "prostaglandin",
"pos": [
259,
272
]
}
|
they found that patients who had been receiving middle-range doses ( 50-70 mg ) of methadone required a significantly lower mean increase in laam than patients who had been receiving either high or low methadone doses and that the patients who accepted laam differed significantly from those who did not in mmpi 2-point-code ratings and mean social adjustment scale scores .
|
NA
|
{
"id": "C0025607",
"name": "laam",
"pos": [
141,
145
]
}
|
{
"id": "C0025605",
"name": "methadone",
"pos": [
202,
211
]
}
|
the authors report a favorable clinical response to lithium carbonate in a father and son with an apparent schizo-affective syndromes may respond favorably to lithium but caution that a favorable response in such cases does not absolutely confirm a diagnosis of mania .
|
NA
|
{
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
52,
69
]
}
|
{
"id": "C0023870",
"name": "lithium",
"pos": [
159,
166
]
}
|
this work examines the scope and accuracy of ct in the detection of tumors , abscesses , cysts , and parenchymal disorders of the liver .
|
NA
|
{
"id": "C0027651",
"name": "tumors",
"pos": [
68,
74
]
}
|
{
"id": "C0010709",
"name": "cysts",
"pos": [
89,
94
]
}
|
patients with previously untreated borderline-lepromatous or fully lepromatous leprosy were treated with one of five clofazimine ( b663 ) regimens : 1 ) 200 mg daily 6 days per week ;
|
NA
|
{
"id": "C1562585",
"name": "borderline-lepromatous",
"pos": [
35,
57
]
}
|
{
"id": "C0023348",
"name": "lepromatous",
"pos": [
67,
78
]
}
|
an aggressive surgical approach is therefore warranted in patients with cholelithiasis , even when silent stones are involved .
|
NA
|
{
"id": "C0008350",
"name": "cholelithiasis",
"pos": [
72,
86
]
}
|
{
"id": "C0006736",
"name": "stones",
"pos": [
106,
112
]
}
|
fibroblasts were cultured from autologous dermal connective tissue of albino rabbits and implanted ( 1 x 10 ( 6 ) -3 x 10 ( 6 ) cells ) into the vitreous space of 18 rabbit eyes under sterile surgical conditions .
|
NA
|
{
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
}
|
{
"id": "C0007634",
"name": "cells",
"pos": [
128,
133
]
}
|
most of the cells in the equator region show several properties of glia cells whereas these of the ora resemble fibroblasts .
|
NA
|
{
"id": "C0007634",
"name": "cells",
"pos": [
12,
17
]
}
|
{
"id": "C0016030",
"name": "fibroblasts",
"pos": [
112,
123
]
}
|
intestinal lymphangiectasia , a disease characterized by excessive intestinal protein loss , asymmetrical peripheral edema , ascites , immunologic deficiencies , lymphocytopenia , hypoalbuminemia , imparied lymphocyte transformation , gastrointestinal symptoms and retarded growth , is the result of abnormal , distorted and obstructed lymph channels , causing rupture of intestinal lacteals from back-flow of lymph , with leakage of nutrient-laden lymph into the lumen of the bowel .
|
NA
|
{
"id": "C0021051",
"name": "immunologic deficiencies",
"pos": [
135,
159
]
}
|
{
"id": "C0024312",
"name": "lymphocytopenia",
"pos": [
162,
177
]
}
|
ninety-eight patients with the gonococcal arthritis-dermatitis syndrome were prospectively treated with penicillin g , at least 10 million units intravenously per day , followed by ampicillin , 2.0 g orally per day , to complete at least 10 days of treatment ( 33 patients ) ;
|
NA
|
{
"id": "C0030827",
"name": "penicillin g",
"pos": [
104,
116
]
}
|
{
"id": "C0002680",
"name": "ampicillin",
"pos": [
181,
191
]
}
|
finally , mutant cell lines have been recovered which produce defective immunoglobulins similar to those found in heavy-chain disease and some other lymphoproliferative disorders .
|
NA
|
{
"id": "C0018852",
"name": "heavy-chain disease",
"pos": [
114,
133
]
}
|
{
"id": "C0024314",
"name": "lymphoproliferative disorders",
"pos": [
149,
178
]
}
|
the fate of the antigen-antibody complexes formed at the cell surface has been studied by means of the lymphocytoxicity test in the presence of rabbit complement , radiolabelled antibodies and the indirect immunofluorescence technique .
|
NA
|
{
"id": "C0003313",
"name": "antigen-antibody complexes",
"pos": [
16,
42
]
}
|
{
"id": "C0003241",
"name": "antibodies",
"pos": [
178,
188
]
}
|
the same protocol applied to the other two antibodies studied showed that anti-beta2 microglobulin antibodies were recovered both as macromolecular and 7 s immune complexes , whereas anti-hl-a antibodies were recovered as macromolecular , 7 s and still smaller immune complexes .
|
NA
|
{
"id": "C0003241",
"name": "antibodies",
"pos": [
43,
53
]
}
|
{
"id": "C0003313",
"name": "immune complexes",
"pos": [
261,
277
]
}
|
in 23 out of 25 strains tested , these resistances were r mediated and linked to multiresistant plasmids , carrying genes for resistances to five other aminoglycosides , tobramycin , kanamycin , neomycin , streptomycin , and spectinomycin , and for resistances to chloramphenicol , tetracycline , sulfonamides , and mercury chloride .
|
NA
|
{
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
152,
167
]
}
|
{
"id": "C0038425",
"name": "streptomycin",
"pos": [
206,
218
]
}
|
in 23 out of 25 strains tested , these resistances were r mediated and linked to multiresistant plasmids , carrying genes for resistances to five other aminoglycosides , tobramycin , kanamycin , neomycin , streptomycin , and spectinomycin , and for resistances to chloramphenicol , tetracycline , sulfonamides , and mercury chloride .
|
NA
|
{
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
152,
167
]
}
|
{
"id": "C0001268",
"name": "spectinomycin",
"pos": [
225,
238
]
}
|
in the present study , however , a simpler more potent antimicrobial substance with a phosphorylated structure similar to the purine adenine was isolated from the berries .
|
NA
|
{
"id": "C0034140",
"name": "purine",
"pos": [
126,
132
]
}
|
{
"id": "C0001407",
"name": "adenine",
"pos": [
133,
140
]
}
|
high kidney concentrations of gentamicin or amikacin , measured by an enzymological assay , were found in 9 of 10 patients who died during therapy with these aminoglycosides .
|
NA
|
{
"id": "C0017436",
"name": "gentamicin",
"pos": [
30,
40
]
}
|
{
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
158,
173
]
}
|
a large inoculum ( 3 x 10 ( 7 ) ) of strains with high mics in tsb almost completely inactivated 50 mug of cefazolin per ml in 6 h , with progressively less inactivation , in the following order , of cephaloridine , cephalexin , cephradine , cephapirin , and cefamandole ;
|
NA
|
{
"id": "C0007716",
"name": "cephalexin",
"pos": [
216,
226
]
}
|
{
"id": "C0007738",
"name": "cephradine",
"pos": [
229,
239
]
}
|
among the penicillins , cloxacillin , dicloxacillin , and nafcillin were most active , although benzylpenicillin and phenoxymethyl penicillin were more active against susceptible strains .
|
NA
|
{
"id": "C0030842",
"name": "penicillins",
"pos": [
10,
21
]
}
|
{
"id": "C0027324",
"name": "nafcillin",
"pos": [
58,
67
]
}
|
among the penicillins , cloxacillin , dicloxacillin , and nafcillin were most active , although benzylpenicillin and phenoxymethyl penicillin were more active against susceptible strains .
|
NA
|
{
"id": "C0030842",
"name": "penicillins",
"pos": [
10,
21
]
}
|
{
"id": "C0030840",
"name": "phenoxymethyl penicillin",
"pos": [
117,
141
]
}
|
among the penicillins , cloxacillin , dicloxacillin , and nafcillin were most active , although benzylpenicillin and phenoxymethyl penicillin were more active against susceptible strains .
|
NA
|
{
"id": "C0009077",
"name": "cloxacillin",
"pos": [
24,
35
]
}
|
{
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
38,
51
]
}
|
among the macrolide-lincomycin compounds in clinical use , clindamycin was more active , and lincomycin was less active than erythromycin .
|
NA
|
{
"id": "C0008947",
"name": "clindamycin",
"pos": [
59,
70
]
}
|
{
"id": "C0023726",
"name": "lincomycin",
"pos": [
93,
103
]
}
|
resting cells of p. stutzeri , cryptococcus terreus , escherichia coli , and xanthomonas campestris formed dimethylnitrosamine , although no nitrosamine was found in growing cultures of the latter three organisms .
|
NA
|
{
"id": "C0012431",
"name": "dimethylnitrosamine",
"pos": [
107,
126
]
}
|
{
"id": "C0028197",
"name": "nitrosamine",
"pos": [
141,
152
]
}
|
boiled cells of p. stutzeri , but not those of c. terreus , e. coli , and x. campestris , formed dimethylnitrosamine , and this nitrosamine was also produced by extracts of e. coli cells at ph 5.0 .
|
NA
|
{
"id": "C0012431",
"name": "dimethylnitrosamine",
"pos": [
97,
116
]
}
|
{
"id": "C0028197",
"name": "nitrosamine",
"pos": [
128,
139
]
}
|
necrotic colitis in the absence of organic obstruction of the mesenteric vessels is an extreme and fulminant form of ischemic colitis .
|
NA
|
{
"id": "C0009319",
"name": "colitis",
"pos": [
9,
16
]
}
|
{
"id": "C0162529",
"name": "ischemic colitis",
"pos": [
117,
133
]
}
|
patch tests reactions to human dander were positive in 120 of 181 ( 66 % ) patients with atopic dermatitis , in two of 28 ( 7 % ) patients with allergic contact dermatitis , and in one of 31 ( 3 % ) normal controls .
|
NA
|
{
"id": "C0011615",
"name": "atopic dermatitis",
"pos": [
89,
106
]
}
|
{
"id": "C0011603",
"name": "dermatitis",
"pos": [
161,
171
]
}
|
twenty-five adult mongrel dogs were infused with sodium pentobarbital ( 60 mg/min ) until their cardiac output fell to 50+/-5 % of the average control values determined by thermodilution technique prior to pentobarbital infusion .
|
NA
|
{
"id": "C0700349",
"name": "sodium pentobarbital",
"pos": [
49,
69
]
}
|
{
"id": "C0030883",
"name": "pentobarbital",
"pos": [
206,
219
]
}
|
the starting sample consisted of 146 patients receiving low-dose methadone , 142 patients receiving methadyl acetate .
|
NA
|
{
"id": "C0025605",
"name": "methadone",
"pos": [
65,
74
]
}
|
{
"id": "C0025607",
"name": "methadyl acetate",
"pos": [
100,
116
]
}
|
it is concluded that methadyl acetate is as safe a drug as methadone and that it compares favorably with highdose methoadone in terms of efficacy .
|
NA
|
{
"id": "C0025607",
"name": "methadyl acetate",
"pos": [
21,
37
]
}
|
{
"id": "C0025605",
"name": "methadone",
"pos": [
59,
68
]
}
|
one third of the stillborn infants of more than 28 weeks ' gestation were associated with maternal complications ( diabetes , preeclampsia , and urinary tract infection ) , in addition to placental fetal vasculopathy , ischemia , infarcts , and chorangiosis ( villous capillary hyperplasia ) .
|
NA
|
{
"id": "C0022116",
"name": "ischemia",
"pos": [
219,
227
]
}
|
{
"id": "C0021308",
"name": "infarcts",
"pos": [
230,
238
]
}
|
the effect of potassium orotate on the ultrastructure of fibroblasts and synthesis of rna by these cells in the course of healing of experimental skin wounds were studied .
|
NA
|
{
"id": "C0016030",
"name": "fibroblasts",
"pos": [
57,
68
]
}
|
{
"id": "C0007634",
"name": "cells",
"pos": [
99,
104
]
}
|
under the effect of potassium orotate on accelerated differentiation of fibroblasts was noted , which was accompanied by the appearance of cells with well developed granular endoplasmatic network , with intensive inclusion of a labeled precursor of rna , earlier , as compared with controls , healing of the wounds .
|
NA
|
{
"id": "C0016030",
"name": "fibroblasts",
"pos": [
72,
83
]
}
|
{
"id": "C0007634",
"name": "cells",
"pos": [
139,
144
]
}
|
the kindling preparation appears to possess many desirable features as an ideal model of human epilepsy for the purpose of assessment and recruitment of potential antiepileptic drugs and development of a rational pharmacotherapeutic approach for the management and prevention of seizure disorder .
|
NA
|
{
"id": "C0014544",
"name": "epilepsy",
"pos": [
95,
103
]
}
|
{
"id": "C0036572",
"name": "seizure",
"pos": [
279,
286
]
}
|
the effect of pilocarpine hydrochloride on the anterior chamber depth and lens thickness was measured in 20 eyes of patients with chronic open-angle glucoma who were receiving long-term glaucoma therapy with pilocarpine .
|
NA
|
{
"id": "C0770456",
"name": "pilocarpine hydrochloride",
"pos": [
14,
39
]
}
|
{
"id": "C0031923",
"name": "pilocarpine",
"pos": [
208,
219
]
}
|
in contrast to osteogenic osteosarcoma the prognosis for early well treated juxtacortical osteosarcoma is much better .
|
NA
|
{
"id": "C0029463",
"name": "osteosarcoma",
"pos": [
26,
38
]
}
|
{
"id": "C0206642",
"name": "juxtacortical osteosarcoma",
"pos": [
76,
102
]
}
|
early complications comprise luxation of the prosthesis , bleeding and hematoma formation , iliotibial-nerve syndrome , phlebothrombosis , embolism , early infection .
|
NA
|
{
"id": "C0019080",
"name": "bleeding",
"pos": [
58,
66
]
}
|
{
"id": "C0018944",
"name": "hematoma",
"pos": [
71,
79
]
}
|
mycoplasma gallisepticum and m. synoviae membranes were obtained by lysing mycoplasma cells with carbonate bicarbonate buffer at ph 10 .
|
NA
|
{
"id": "C0007026",
"name": "carbonate",
"pos": [
97,
106
]
}
|
{
"id": "C0005367",
"name": "bicarbonate",
"pos": [
107,
118
]
}
|
changes in plasma glucose , insulin , and growth hormone ( hgh ) resulting from exposure to 56 d of bedrest were determined in five healthy young male subjects .
|
NA
|
{
"id": "C0037663",
"name": "growth hormone",
"pos": [
42,
56
]
}
|
{
"id": "C3714500",
"name": "hgh",
"pos": [
59,
62
]
}
|
the influence of adenine nucleotides and oxidizable substrates on triethyltin-mediated chloride uptake by rat liver mitochondria in potassium chloride media .
|
NA
|
{
"id": "C0008203",
"name": "chloride",
"pos": [
87,
95
]
}
|
{
"id": "C0032825",
"name": "potassium",
"pos": [
132,
141
]
}
|
poly ( adp-ribose ) polymerase is inhibited by atp , thymidine , nicotinamide , theophylline , 3-isobutyl-1-methylxanthine and caffeine and stimulated by actinomycin d .
|
NA
|
{
"id": "C0039771",
"name": "theophylline",
"pos": [
80,
92
]
}
|
{
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
95,
122
]
}
|
the synthesis of 28s and 18s rrna could be detected within 1h of the injection of the radioactive precursor and appeared to be more pronounced , relative to other high-molecular-weight rna , in the brains of older rats compared with those of newborn rats .
|
NA
|
{
"id": "C0035701",
"name": "rrna",
"pos": [
29,
33
]
}
|
{
"id": "C0035668",
"name": "rna",
"pos": [
185,
188
]
}
|
two strains ( cp78 and cp79 ) , isogenic except for rel , showed similar behaviour with respect to ( 1 ) the kinetics of labelling total rna and ribosomes with exogenous uracil , ( 2 ) the proportion of newly formed protein that could be bound with nascent rrna in mature ribosomes , and ( 3 ) the rate of induction of enzymically active beta-galactosidase ( relative to the rate of ribosome synthesis ) .
|
NA
|
{
"id": "C0035668",
"name": "rna",
"pos": [
137,
140
]
}
|
{
"id": "C0035701",
"name": "rrna",
"pos": [
257,
261
]
}
|
it was concluded that , as there was no net accumulation of rna during stepdown in either strain , rrna turnover must be occurring at a high rate .
|
NA
|
{
"id": "C0035668",
"name": "rna",
"pos": [
60,
63
]
}
|
{
"id": "C0035701",
"name": "rrna",
"pos": [
99,
103
]
}
|
these results support the hypothesis that amino acids are converted into pyruvate before oxidation and that some pyruvate is transaminated to alanine , which is released from the muscle .
|
NA
|
{
"id": "C0002520",
"name": "amino acids",
"pos": [
42,
53
]
}
|
{
"id": "C0001898",
"name": "alanine",
"pos": [
142,
149
]
}
|
the enzyme was active with pyruvate as amino acceptor but not with 2-oxoglutarate , and utilized various aromatic amino acids as amino donors in the following order of activity : phenylalanine greater than tyrosine greater than histidine .
|
NA
|
{
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
105,
125
]
}
|
{
"id": "C0031453",
"name": "phenylalanine",
"pos": [
179,
192
]
}
|
the enzyme was active with pyruvate as amino acceptor but not with 2-oxoglutarate , and utilized various aromatic amino acids as amino donors in the following order of activity : phenylalanine greater than tyrosine greater than histidine .
|
NA
|
{
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
105,
125
]
}
|
{
"id": "C0041485",
"name": "tyrosine",
"pos": [
206,
214
]
}
|
the order of effectiveness of amino donors was tyrosine = phenylalanine greater than histidine greater than tryptophan greater than 5-hydroxytryptophan .
|
NA
|
{
"id": "C0041249",
"name": "tryptophan",
"pos": [
108,
118
]
}
|
{
"id": "C0000578",
"name": "hydroxytryptophan",
"pos": [
134,
151
]
}
|
amino acid and sugar analyses of the highly purified enzyme indicated an acidic glycoprotein containing 57 % sugar ( neutral sugars 47 % , amino sugars 10 % ) .
|
NA
|
{
"id": "C0007004",
"name": "sugar",
"pos": [
15,
20
]
}
|
{
"id": "C0002531",
"name": "amino sugars",
"pos": [
139,
151
]
}
|
( circular dichroism ) of drosophila melanogaster rrna ( 42 % g+c ) and of g+c-rich fragments ( 78 % g+c ) obtained by partial hydrolysis of rabbit l-rrna ( the largest rna species isolated from the large subribosomal particle ) were measured and found to differ substantially .
|
NA
|
{
"id": "C0035701",
"name": "rrna",
"pos": [
50,
54
]
}
|
{
"id": "C0035668",
"name": "rna",
"pos": [
169,
172
]
}
|
a frame of reference was established by studying the c.d . of a range of rrna species , including s-rrna ( the rna species isolated from the smaller subribosomal particle ) and l-rrna of escherichia coli .
|
NA
|
{
"id": "C0035668",
"name": "rna",
"pos": [
74,
77
]
}
|
{
"id": "C0035701",
"name": "rrna",
"pos": [
179,
183
]
}
|
a homogeneous preparation of penicillinase ( penicillin amido-beta-lactamhydrolase , ec 3.5.2.6 ) was isolated and purified from cultures of staphylococcus aureus by a simple two-stage procedure .
|
NA
|
{
"id": "C0030841",
"name": "penicillinase",
"pos": [
29,
42
]
}
|
{
"id": "C0597979",
"name": "beta-lactamhydrolase",
"pos": [
62,
82
]
}
|
the extent of digestion of tropocollagen within polymeric collagen was linear over a very small range of enzyme concentrations , when the enzyme/substrate ratio in the reaction mixture was less than 1:400 on a molecular basis .
|
NA
|
{
"id": "C0041193",
"name": "tropocollagen",
"pos": [
27,
40
]
}
|
{
"id": "C0009325",
"name": "collagen",
"pos": [
58,
66
]
}
|
in explants about 10 % of the cells were round and formed rosettes with igc and c3 markers , whereas the remaining cells were stellate , resembled young fibroblasts , and had no receptors for igg and complement .
|
NA
|
{
"id": "C0007634",
"name": "cells",
"pos": [
30,
35
]
}
|
{
"id": "C0016030",
"name": "fibroblasts",
"pos": [
153,
164
]
}
|
monolayer cells looked like fibroblasts , produced fine extracellular fibrils and hyaluronate , and formed no rosettes .
|
NA
|
{
"id": "C0007634",
"name": "cells",
"pos": [
10,
15
]
}
|
{
"id": "C0016030",
"name": "fibroblasts",
"pos": [
28,
39
]
}
|
this was found to be in the following ascending order : alkylbenzylmethyl-ammonium chloride , alkyltrimethylammonium bromide , cetyltrimethylammonium bromide , cetylpyrimidinium chloride and cetylbenzyldimethylammonium chloride .
|
NA
|
{
"id": "C0002615",
"name": "ammonium chloride",
"pos": [
74,
91
]
}
|
{
"id": "C0008203",
"name": "chloride",
"pos": [
219,
227
]
}
|
a method is described which allows the separate determination of carbon disulfide , free diethyldithiocarbamate and disulfides derived from disulfiram with adequate precision in 10 ml patient blood .
|
NA
|
{
"id": "C0012771",
"name": "disulfides",
"pos": [
116,
126
]
}
|
{
"id": "C0012772",
"name": "disulfiram",
"pos": [
140,
150
]
}
|
the influence of propranolol ( 0.3 and 1.0 mg/kg ) and of d , l-4- ( 2-hydroxy-3-isopropylamino-propoxy ) -indol-hydrochloride ( pindolol , lb 46 ) ( 0.10 , 0.25 and 0.50 mg/kg ) on the responses of plasma potassium levels of anaesthetized dogs to slow i.v . infusions of adrenaline , noradrenaline and isoprenaline ( 5 mug/kg-min-1 ) was studied .
|
NA
|
{
"id": "C0014563",
"name": "adrenaline",
"pos": [
272,
282
]
}
|
{
"id": "C0028351",
"name": "noradrenaline",
"pos": [
285,
298
]
}
|
adrenaline and noradrenaline infusions regularly evoked a dual response ( hyperkaliemia followed by hypokaliemia ) , whereas isoprenaline caused either similar effects or only a decrease of plasma potassium .
|
NA
|
{
"id": "C0014563",
"name": "adrenaline",
"pos": [
0,
10
]
}
|
{
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
}
|
pindolol antagonized in a dose dependent way the hypokaliemic phase of the responses to adrenaline , noradrenaline and isoprenaline , but did not interfere with the early rise in plasma potassium , thus being more specific than propranolol .
|
NA
|
{
"id": "C0014563",
"name": "adrenaline",
"pos": [
88,
98
]
}
|
{
"id": "C0028351",
"name": "noradrenaline",
"pos": [
101,
114
]
}
|
in accordance with the results achieved in previous experiments the intestinal absorption of magnesium and its uptake into bone of rats were significantly improved when mgcl2 or mono-magnesium-mono-aspartate-hydrochloride ( mg asp . hcl ) were used instead of mono-magnesium-di-l-aspartate ( mg asp . ) .
|
NA
|
{
"id": "C0024467",
"name": "magnesium",
"pos": [
93,
102
]
}
|
{
"id": "C0024472",
"name": "mgcl2",
"pos": [
169,
174
]
}
|
in accordance with the results achieved in previous experiments the intestinal absorption of magnesium and its uptake into bone of rats were significantly improved when mgcl2 or mono-magnesium-mono-aspartate-hydrochloride ( mg asp . hcl ) were used instead of mono-magnesium-di-l-aspartate ( mg asp . ) .
|
NA
|
{
"id": "C0024467",
"name": "magnesium",
"pos": [
93,
102
]
}
|
{
"id": "C0543448",
"name": "magnesium",
"pos": [
265,
274
]
}
|
treatment with mono-magnesium-mono-aspartate-hydrobromide ( mg asp . hbr ) resulted in remarkably elevated magnesium concentrations in plasma and bone .
|
NA
|
{
"id": "C0543448",
"name": "magnesium",
"pos": [
20,
29
]
}
|
{
"id": "C0024467",
"name": "magnesium",
"pos": [
107,
116
]
}
|
the blockade was partially antagonized by physostigmine , adrenaline , succinylcholine , choline , tetraethylammonium and kcl and was additive to that due to tubocurarine .
|
NA
|
{
"id": "C0038627",
"name": "succinylcholine",
"pos": [
71,
86
]
}
|
{
"id": "C0008405",
"name": "choline",
"pos": [
89,
96
]
}
|
a ) flupentixol or fluphenazine applied in optimal dosage , increased the excretion of urea and the amino acids asp , glu + gln , and gly .
|
NA
|
{
"id": "C0002520",
"name": "amino acids",
"pos": [
100,
111
]
}
|
{
"id": "C0017890",
"name": "gly",
"pos": [
134,
137
]
}
|
a ) flupentixol or fluphenazine applied in optimal dosage , increased the excretion of urea and the amino acids asp , glu + gln , and gly .
|
NA
|
{
"id": "C0061472",
"name": "glu",
"pos": [
118,
121
]
}
|
{
"id": "C0017797",
"name": "gln",
"pos": [
124,
127
]
}
|
the usual desalting procedure by ion-exchanging resins before chromatography increases the contents of several amino acids , e.g . asp , asn , ala , gly , cys , ser , thr , indicating a breakdown of some instable products .
|
NA
|
{
"id": "C0002520",
"name": "amino acids",
"pos": [
111,
122
]
}
|
{
"id": "C0017890",
"name": "gly",
"pos": [
149,
152
]
}
|
our findings suggest that ( i ) arginine and guanidinoacetate must be converted to creatine before serving as a suppressor , and ( ii ) creatine , not phosphocreatine , is most closely related to the physiological suppressor of amidinotransferase .
|
NA
|
{
"id": "C0010286",
"name": "creatine",
"pos": [
83,
91
]
}
|
{
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
151,
166
]
}
|
the ratio of the experimentally determined free energy of transfer to the free energy of transfer of the 100 % accessible protein gave 11 % accessible surface area for the native protein in 1 m gdnhcl or 2 m urea .
|
NA
|
{
"id": "C0033684",
"name": "protein",
"pos": [
122,
129
]
}
|
{
"id": "C0025252",
"name": "surface",
"pos": [
151,
158
]
}
|
the amino acid composition reveals a high proportion of alanine and acidic amino acids , a normal content of aromatic amino acids , and the absence of histidine .
|
NA
|
{
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
}
|
{
"id": "C0001898",
"name": "alanine",
"pos": [
56,
63
]
}
|
the amino acid composition reveals a high proportion of alanine and acidic amino acids , a normal content of aromatic amino acids , and the absence of histidine .
|
NA
|
{
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
}
|
{
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
68,
86
]
}
|
the fact that this order is parallel to the relative rates of inactivation of the enzymes and the enzyme-dna complex suggests that the inactivation may be due to the rifampicin-induced isomerization ( conformational change ) of the enzyme .
|
NA
|
{
"id": "C0026741",
"name": "enzyme",
"pos": [
82,
88
]
}
|
{
"id": "C0014442",
"name": "enzyme",
"pos": [
232,
238
]
}
|
the results suggest that the altered carbodiimide-reactive proteolipid in the dicyclohexylcarbodiimide-resistant mutant is specifically defective in its ability to react with lipophilic carbodiimides .
|
NA
|
{
"id": "C0012124",
"name": "dicyclohexylcarbodiimide",
"pos": [
78,
102
]
}
|
{
"id": "C0006993",
"name": "carbodiimides",
"pos": [
186,
199
]
}
|
purification involves the isolation of membrane-bound polysomes , oligo ( dt ) -cellulose chromatography , and sucrose gradient centrifugation under conditions favoring denaturation of polynucleotide complexes .
|
NA
|
{
"id": "C0028953",
"name": "oligo",
"pos": [
66,
71
]
}
|
{
"id": "C0032550",
"name": "polynucleotide",
"pos": [
185,
199
]
}
|
the phosphoramidate polynucleotides range in size from about 100 nucleotide units to well over a thousand nucleotide units , and the size is increased by addition of dna ligase to the system .
|
NA
|
{
"id": "C0032550",
"name": "polynucleotides",
"pos": [
20,
35
]
}
|
{
"id": "C0028630",
"name": "nucleotide",
"pos": [
106,
116
]
}
|
these experiments indicate that synthetic polynucleotides in which oligonucleotide blocks have been joined by means of phosphoramidate bonds should prove useful as primers for enzymatic syntheses with dna polymerase i .
|
NA
|
{
"id": "C0032550",
"name": "polynucleotides",
"pos": [
42,
57
]
}
|
{
"id": "C0028953",
"name": "oligonucleotide",
"pos": [
67,
82
]
}
|
relative to the unliganded enzyme , the nadph-enzyme complex was more thermostable and showed a twofold greater rate of tryptic inactivation , while the nadp+-enzyme complex was more thermolabile and only slightly more susceptible to tryptic inactivation .
|
NA
|
{
"id": "C0014442",
"name": "enzyme",
"pos": [
27,
33
]
}
|
{
"id": "C0026741",
"name": "enzyme",
"pos": [
159,
165
]
}
|
nh2-terminal extensions on skin collagen from sheep with a genetic defect in conversion of procollagen into collagen .
|
NA
|
{
"id": "C0033235",
"name": "procollagen",
"pos": [
91,
102
]
}
|
{
"id": "C0009325",
"name": "collagen",
"pos": [
108,
116
]
}
|
a modified form of procollagen was extracted with 10 m urea from the skin of lambs with dermatosparaxis , a disease which is produced by a genetic defect in the conversion of procollagen to collagen .
|
NA
|
{
"id": "C0033235",
"name": "procollagen",
"pos": [
19,
30
]
}
|
{
"id": "C0009325",
"name": "collagen",
"pos": [
190,
198
]
}
|
the larger cyanogen bromide fragment contained 8 residues of hydroxyproline , 12 residues of proline , and 19 residues of glycine not found in the nh2-terminal fragment isolated after digestion with bacterial collagenase .
|
NA
|
{
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
61,
75
]
}
|
{
"id": "C0033382",
"name": "proline",
"pos": [
93,
100
]
}
|
the enriched compounds were [ 1,3-15n ] riboflavin , [ 1,3,5-15n ] riboflavin , [ 1,3-15n ] riboflavin 5'-phosphate , [ 1,3,5-15n ] riboflavin 5'-phosphate , and [ 1,3,5-15n ] flavin adenine dinucleotide , [ 1,3,5-15n ] lumiflavin , and [ 1,3,5-15n ] lumichrome .
|
NA
|
{
"id": "C0035527",
"name": "riboflavin",
"pos": [
40,
50
]
}
|
{
"id": "C0016388",
"name": "riboflavin 5",
"pos": [
132,
144
]
}
|
if mersalyl and carbonyl cyanide m-chlorophenylhydrazone ( cccp ) were added 3 min after pre-incubation with phosphate the same intramitochondrial concentration of the anion as in control experiments was found , whereas the activity of glutaminase was severely inhibited .
|
NA
|
{
"id": "C0010505",
"name": "cyanide",
"pos": [
25,
32
]
}
|
{
"id": "C0003075",
"name": "anion",
"pos": [
168,
173
]
}
|
if mersalyl and carbonyl cyanide m-chlorophenylhydrazone ( cccp ) were added 3 min after pre-incubation with phosphate the same intramitochondrial concentration of the anion as in control experiments was found , whereas the activity of glutaminase was severely inhibited .
|
NA
|
{
"id": "C0031603",
"name": "phosphate",
"pos": [
109,
118
]
}
|
{
"id": "C0003075",
"name": "anion",
"pos": [
168,
173
]
}
|
the mechanism whereby theophylline leads to a decrease in lipogenesis and in the synthesis of fatty acid synthetase may not be mediated entirely by inhibition of phosphodiesterase and an increase in cyclic amp levels , because dibutyryl cyclic amp ( 10 ( -3 ) m ) only partially reproduced the effect .
|
NA
|
{
"id": "C0001455",
"name": "cyclic amp",
"pos": [
199,
209
]
}
|
{
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
227,
247
]
}
|
the different platelet phospholipid fractions analyzed were also highly enriched with 20:3omega6 , whereas the arachidonic acid content in platelet phospholipids was significantly lower than in control animals .
|
NA
|
{
"id": "C0771648",
"name": "phospholipid fractions",
"pos": [
23,
45
]
}
|
{
"id": "C0031676",
"name": "phospholipids",
"pos": [
148,
161
]
}
|
choline-based phospholipids of liver , kidney , lung and brain were extracted , and phosphocholine incorporation calculated from 31p-nmr peak area ratios .
|
NA
|
{
"id": "C0008405",
"name": "choline",
"pos": [
0,
7
]
}
|
{
"id": "C0031716",
"name": "phosphocholine",
"pos": [
84,
98
]
}
|
variations in 14c/3h ratio between feed and phospholipid extracts indicated preferences for exogenous choline over phosphocholine varying from 1.3 : 1 in brain to 3.2 : 1 in liver .
|
NA
|
{
"id": "C0008405",
"name": "choline",
"pos": [
102,
109
]
}
|
{
"id": "C0031716",
"name": "phosphocholine",
"pos": [
115,
129
]
}
|
galactosylgalactosylglucosylceramide levels were 3-5 times normal in all three patients with fabry 's disease , and in two the distribution of the excess lipid among the major lipoprotein fractions was similar to that in the control group .
|
NA
|
{
"id": "C0023779",
"name": "lipid",
"pos": [
154,
159
]
}
|
{
"id": "C0023820",
"name": "lipoprotein",
"pos": [
176,
187
]
}
|
skin surface lipids of the guinea pig were found to contain sterol esters ( 33 % ) , wax diesters ( diacyl alkanediols ) ( 24 % ) , glycerol ether diesters ( 28 % ) , free fatty alcohols ( 6 % ) and free sterols ( 9 % ) .
|
NA
|
{
"id": "C0023779",
"name": "lipids",
"pos": [
13,
19
]
}
|
{
"id": "C0043076",
"name": "wax",
"pos": [
85,
88
]
}
|
sn-glycero-3-phosphocholine diesterase activities , glycerophosphohydrolase ( ec 3.1.4.2 ) and choline phosphohydrolase ( ec 3.1.4.38 ) from rat brain have been partially purified and characterized using sn-glycere-3- [ 32p ] phosphocholine as substrate and separating the reaction products by anion-exchange chromatography and ionophoresis .
|
NA
|
{
"id": "C0008405",
"name": "choline",
"pos": [
20,
27
]
}
|
{
"id": "C0031716",
"name": "phosphocholine",
"pos": [
226,
240
]
}
|
these studies have shown that blue dextran agarose possesses unique biospecific and nonbiospecific properties , both of which are essential to achieve resolution of factor x from other vitamin k-dependent blood clotting factors .
|
NA
|
{
"id": "C0015518",
"name": "factor x",
"pos": [
165,
173
]
}
|
{
"id": "C0005789",
"name": "blood clotting factors",
"pos": [
205,
227
]
}
|
this analysis indicated that autoclaved ligament elastin contains approximately 18 glutamine , 3 asparagine , 4 glutamic acid and 5 aspartic acid residues per 1000 residues , in good agreement with the analysis of total acid-labile ammonia .
|
NA
|
{
"id": "C0017797",
"name": "glutamine",
"pos": [
83,
92
]
}
|
{
"id": "C0061472",
"name": "glutamic acid",
"pos": [
112,
125
]
}
|
hyperfine couplings from heme protons have also been obtained from metmyoglobin cyanide and from a low spin protohemin cyanide complex .
|
NA
|
{
"id": "C0018966",
"name": "heme",
"pos": [
25,
29
]
}
|
{
"id": "C0018988",
"name": "protohemin",
"pos": [
108,
118
]
}
|
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