text
stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the pseudo-synovium appearing around silastic rods is a labile layer made up of a range of cells from undifferentiated fibroblast precursors through to mature fibrocytes .
|
NA
|
{
"id": "C0007634",
"name": "cells",
"pos": [
91,
96
]
}
|
{
"id": "C0016030",
"name": "fibroblast",
"pos": [
119,
129
]
}
|
the separate identity of a. lumbricoides and a. suum was confirmed by means of the disc electrophoresis method in that differences were established in the protein profile of somatic and ribosomal proteins .
|
NA
|
{
"id": "C0033684",
"name": "protein",
"pos": [
155,
162
]
}
|
{
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
186,
204
]
}
|
the ability of saccharomyces cerevisiae to transport d-galactose and related sugars with an axial hydroxyl group at c-4 , acquired by induction with d-galactose , was lost either by exposing early exponential-phase cells to an osmotic shock involving incubation in 0.6m nac1o4 , 0.66m sucrose and 1mm histidine and transfer to 5mm tris-hc1 with 2mm dithiothreitol , or simply by transferring them to distilled water .
|
NA
|
{
"id": "C0242209",
"name": "sugars",
"pos": [
77,
83
]
}
|
{
"id": "C0038636",
"name": "sucrose",
"pos": [
285,
292
]
}
|
it appears that the biosynthesis of ctc in streptomyces aureofaciens takes place at the expense of glycolysis , using up the high-energy phosphate of high-molecular polyphosphates .
|
NA
|
{
"id": "C0031603",
"name": "phosphate",
"pos": [
137,
146
]
}
|
{
"id": "C0032575",
"name": "polyphosphates",
"pos": [
165,
179
]
}
|
[ 1-14c ] bicarbonate was also incorporated slightly into fatty acids , such as decanoic or dodecanoic acids .
|
NA
|
{
"id": "C0015684",
"name": "fatty acids",
"pos": [
58,
69
]
}
|
{
"id": "C0023140",
"name": "dodecanoic acids",
"pos": [
92,
108
]
}
|
5 ) no changes in the distribution of ethanol were observed within 24 hours when the blood is kept in ice box immediately after sampling , and also in the blood ethanol concentration for at least 20 days under similar conditions .
|
NA
|
{
"id": "C0001962",
"name": "ethanol",
"pos": [
38,
45
]
}
|
{
"id": "C0684262",
"name": "blood ethanol concentration",
"pos": [
155,
182
]
}
|
growth hormone and thyrotrophic hormone content have been measured by specific radioimmunoassays in anterior pituitaries of 22 day old rats .
|
NA
|
{
"id": "C0037663",
"name": "growth hormone",
"pos": [
0,
14
]
}
|
{
"id": "C0032016",
"name": "anterior pituitaries",
"pos": [
100,
120
]
}
|
growth hormone and thyrotrophic hormone content have been measured by specific radioimmunoassays in anterior pituitaries of 22 day old rats .
|
NA
|
{
"id": "C0040160",
"name": "thyrotrophic hormone",
"pos": [
19,
39
]
}
|
{
"id": "C0032016",
"name": "anterior pituitaries",
"pos": [
100,
120
]
}
|
the effects of synthetic linear somatostatin on basal circulating levels on several pituitary and pancreatic hormones , and of glucose and free fatty acids ( ffa ) were studied in 6 normal men after an overnight fast .
|
NA
|
{
"id": "C0037659",
"name": "somatostatin",
"pos": [
32,
44
]
}
|
{
"id": "C0030292",
"name": "pancreatic hormones",
"pos": [
98,
117
]
}
|
in all mucopolysaccharidoses , except morquio disease , an excessive accumulation of sulfate-labeled glycosaminoglycans has been demonstrated in fibroblasts cultured from the patient 's skin .
|
NA
|
{
"id": "C0026703",
"name": "mucopolysaccharidoses",
"pos": [
7,
28
]
}
|
{
"id": "C0026707",
"name": "morquio disease",
"pos": [
38,
53
]
}
|
the amount of this hemoglobin ranges from traces to 40 % of the total hb f .
|
NA
|
{
"id": "C0019046",
"name": "hemoglobin",
"pos": [
19,
29
]
}
|
{
"id": "C0015936",
"name": "hb f",
"pos": [
70,
74
]
}
|
only antitoxin neutralized the adenosine 5'-diphosphate ribosyl-transferase activity of fragment a , but suprisingly both antisera had significant anti-fragment a titers when tested by passive hemagglutination .
|
NA
|
{
"id": "C0003445",
"name": "antitoxin",
"pos": [
5,
14
]
}
|
{
"id": "C0020960",
"name": "antisera",
"pos": [
122,
130
]
}
|
n-acetylmuramyldipeptide and 6-o-stearoyl-n-acetylmuramyldipeptide showed no adjuvant activity in the generation of cell-mediated cytotoxic effector cells in the spleens of c57bl/6j mice after in vivo immunization with the allogeneic antigen mastocytoma p815-x2 cells , but n-acetylmuramyldipeptide showed adjuvant activity after in vitro sensitization of c57bl/6j mouse spleen cells to the alloantigen mitomycin c-treated dba/2 mouse spleen cells .
|
NA
|
{
"id": "C3485979",
"name": "allogeneic",
"pos": [
223,
233
]
}
|
{
"id": "C0007634",
"name": "cells",
"pos": [
442,
447
]
}
|
carbenicillin or ticarcillin were incubated individually with each of the following antibiotics : gentamicin , tobramycin , sisomicin , amikacin .
|
NA
|
{
"id": "C0017436",
"name": "gentamicin",
"pos": [
98,
108
]
}
|
{
"id": "C0037209",
"name": "sisomicin",
"pos": [
124,
133
]
}
|
subunit vaccine was very well tolerated . whereas whole virus vaccine caused systemic reactions , including fever and headache , in 15 % of the volunteers .
|
NA
|
{
"id": "C0887892",
"name": "subunit vaccine",
"pos": [
0,
15
]
}
|
{
"id": "C0042210",
"name": "vaccine",
"pos": [
62,
69
]
}
|
specific sensitization of lymphocytes to tumor antigens by co-cultivation with peritoneal cells exposed to such antigens .
|
NA
|
{
"id": "C0003335",
"name": "tumor antigens",
"pos": [
41,
55
]
}
|
{
"id": "C0003320",
"name": "antigens",
"pos": [
112,
120
]
}
|
by this approach sensitization to individually unique tumor antigens , as well as to antigens shared by mouse embryos and mouse sarcoma cells , was achieved .
|
NA
|
{
"id": "C0003335",
"name": "tumor",
"pos": [
54,
59
]
}
|
{
"id": "C0003320",
"name": "antigens",
"pos": [
85,
93
]
}
|
by means of dna : dna reassociation kinetics , the dna of the mammary tumor cells of these two mouse strains were found to contain more mmtv proviral sequences than the dna of liver cells of these same tumor-bearing mice .
|
NA
|
{
"id": "C0012930",
"name": "dna",
"pos": [
12,
15
]
}
|
{
"id": "C0012854",
"name": "dna",
"pos": [
169,
172
]
}
|
the involvement of anti-tumor antibodies in this phenomenon was indicated by the finding that such antibodies inhibited binding of unrelated immune complexes by young cells but not by old cells .
|
NA
|
{
"id": "C0003241",
"name": "antibodies",
"pos": [
30,
40
]
}
|
{
"id": "C0003313",
"name": "immune complexes",
"pos": [
141,
157
]
}
|
gentamicin , tobramycin , sisomicin , amikacin and kanamycin are compared for therapeutic use by correlating the in vitro minimal inhibitory concentration with the in vivo concentration of the antibiotic attainable in the serum at half the time intervall between two administrations of the drugs .
|
NA
|
{
"id": "C0017436",
"name": "gentamicin",
"pos": [
0,
10
]
}
|
{
"id": "C0037209",
"name": "sisomicin",
"pos": [
26,
35
]
}
|
gentamicin , tobramycin , sisomicin , amikacin and kanamycin are compared for therapeutic use by correlating the in vitro minimal inhibitory concentration with the in vivo concentration of the antibiotic attainable in the serum at half the time intervall between two administrations of the drugs .
|
NA
|
{
"id": "C0002499",
"name": "amikacin",
"pos": [
38,
46
]
}
|
{
"id": "C0022487",
"name": "kanamycin",
"pos": [
51,
60
]
}
|
using this method of evaluation , e. coli , enterobacter and sensitive strains of the klebsiella and pseudomonas species can be treated in principle equally well with gentamicin , tobramycin and sisomicin , and to a large degree also with amikacin .
|
NA
|
{
"id": "C0017436",
"name": "gentamicin",
"pos": [
167,
177
]
}
|
{
"id": "C0037209",
"name": "sisomicin",
"pos": [
195,
204
]
}
|
in unirradiated cfw mice , the bone-marrow camp content was found to be elevated by the administration of noradrenaline , adrenaline and isoproterenol .
|
NA
|
{
"id": "C0028351",
"name": "noradrenaline",
"pos": [
106,
119
]
}
|
{
"id": "C0014563",
"name": "adrenaline",
"pos": [
122,
132
]
}
|
tlc and chemical analysis of inh-mutants suggested that the decrease of the cell lipids was associated with the peptidoglyco-phospholipid fraction , while the neutral lipids were characterized by a most elevated amount of both menaquinone-9 and free fatty acids , and by comparable levels of both glycerides and total fatty acids with respect to the sensitive strain .
|
NA
|
{
"id": "C0023779",
"name": "lipids",
"pos": [
81,
87
]
}
|
{
"id": "C0017860",
"name": "glycerides",
"pos": [
297,
307
]
}
|
tlc and chemical analysis of inh-mutants suggested that the decrease of the cell lipids was associated with the peptidoglyco-phospholipid fraction , while the neutral lipids were characterized by a most elevated amount of both menaquinone-9 and free fatty acids , and by comparable levels of both glycerides and total fatty acids with respect to the sensitive strain .
|
NA
|
{
"id": "C0015688",
"name": "free fatty acids",
"pos": [
245,
261
]
}
|
{
"id": "C0015684",
"name": "fatty acids",
"pos": [
318,
329
]
}
|
the latter antiserum was used successfully for passive immunization as long as there was excess antibody ;
|
NA
|
{
"id": "C0020960",
"name": "antiserum",
"pos": [
11,
20
]
}
|
{
"id": "C0003241",
"name": "antibody",
"pos": [
96,
104
]
}
|
unsubstituted naphthyl substrates were found to be superior to substituted naphthyl , indolyl and hydroxyquinoline substrates for the histochemical demonstration of alpha-mannosidase , alpha-galactosidase , hetero-beta-glycosidase , glucoamylase and sucraseisomaltase , equivalent for beta-n-acetylglucosaminidase and lactase-beta-glucosidase , and inferior for beta-glucuronidase and acid beta-galatosidase .
|
NA
|
{
"id": "C0017976",
"name": "glycosidase",
"pos": [
219,
230
]
}
|
{
"id": "C0017776",
"name": "beta-glucuronidase",
"pos": [
362,
380
]
}
|
its antibacterial activity in vitro ( mic ) is similar , but its bactericidal efficacy superior to that of cephalexin and cephradine .
|
NA
|
{
"id": "C0007716",
"name": "cephalexin",
"pos": [
107,
117
]
}
|
{
"id": "C0007738",
"name": "cephradine",
"pos": [
122,
132
]
}
|
upon oral administration to mice infected with various bacteria , cgp 9000 is , in general , 2 to 7 times more effective than either cephalexin or cephradine .
|
NA
|
{
"id": "C0007716",
"name": "cephalexin",
"pos": [
133,
143
]
}
|
{
"id": "C0007738",
"name": "cephradine",
"pos": [
147,
157
]
}
|
reserpine-rescinnamine group alkaloids are extracted from rauwolfia serpentina preparations into a dimethylsulfoxide ( dmso ) -methanol mixture and diluted with 0.5n h2so4 .
|
NA
|
{
"id": "C0035179",
"name": "reserpine",
"pos": [
0,
9
]
}
|
{
"id": "C0035167",
"name": "group",
"pos": [
23,
28
]
}
|
a portion of the eluate is treated with nitrous acid and the reserpine-rescinnamine content is determined by measuring the intensity of fluorescence of the oxidation product .
|
NA
|
{
"id": "C0035179",
"name": "reserpine",
"pos": [
61,
70
]
}
|
{
"id": "C0035167",
"name": "content",
"pos": [
84,
91
]
}
|
the following means and standard deviations ( 11 collaborators ) were obtained for the determination of reserpine-rescinnamine group alkaloids in 4 samples of rauwolfia serpentina ( nf reference powder , 100 mg and 50 mg commercial tablets , and a 45 mg synthetic tablet formulation ) : 0.174 % +/- 0.0112 , 0.131 % +/- 0.0047 , 0.160 % +/- 0.0100 , and 0.153 % +/- 0.0083 , respectively .
|
NA
|
{
"id": "C0035179",
"name": "reserpine",
"pos": [
104,
113
]
}
|
{
"id": "C0035167",
"name": "group",
"pos": [
127,
132
]
}
|
( ii ) thiamine gave a much faster rate of tpp synthesis than thiamine monophosphate ( tmp ) when determined with the extracts ;
|
NA
|
{
"id": "C0039840",
"name": "thiamine",
"pos": [
7,
15
]
}
|
{
"id": "C0039845",
"name": "thiamine monophosphate",
"pos": [
62,
84
]
}
|
and ( iii ) a partially purified preparation of the extracts can use thiamine , but not tmp , as the substrate .
|
NA
|
{
"id": "C0039840",
"name": "thiamine",
"pos": [
69,
77
]
}
|
{
"id": "C0039845",
"name": "tmp",
"pos": [
88,
91
]
}
|
the activities of the four enzymes involved in tmp synthesis from pyrimidine and thiazole moieties of thiamine were detected in the extracts of m. denitrificans .
|
NA
|
{
"id": "C0039845",
"name": "tmp",
"pos": [
47,
50
]
}
|
{
"id": "C0039840",
"name": "thiamine",
"pos": [
102,
110
]
}
|
these results indicate that tpp is synthesized directly from thiamine without forming tmp as an intermediate and that de novo synthesis of tpp from the pyrimidine and thiazole moieties involves the formation of tmp , followed by hydrolysis to thiamine , which is then converted to tpp directly .
|
NA
|
{
"id": "C0039845",
"name": "tmp",
"pos": [
86,
89
]
}
|
{
"id": "C0039840",
"name": "thiamine",
"pos": [
243,
251
]
}
|
thus , the pathway of tpp synthesis from tmp synthesized de novo in m. denitrificans is different from that found in e. coli , in which tmp synthesized de novo is converted directly to tpp without producing thiamine .
|
NA
|
{
"id": "C0039845",
"name": "tmp",
"pos": [
41,
44
]
}
|
{
"id": "C0039840",
"name": "thiamine",
"pos": [
207,
215
]
}
|
the ability of supm to suppress both nonsense and missense mutations can be explained if it is derived from a tyrosine transfer ribonucleic acid with a modified base in the first position of the anticodon .
|
NA
|
{
"id": "C0035711",
"name": "transfer ribonucleic acid",
"pos": [
119,
144
]
}
|
{
"id": "C0003284",
"name": "anticodon",
"pos": [
195,
204
]
}
|
polyacrylamide gel electrophoresis of the ribosomal ribonucleic acid from the 50s and 30s rnp particles confirmed their precursor nature since they were shown to contain precursor 23s and 16s ribosomal ribonucleic acid , respectively .
|
NA
|
{
"id": "C0035701",
"name": "ribosomal ribonucleic acid",
"pos": [
42,
68
]
}
|
{
"id": "C0035702",
"name": "16s",
"pos": [
188,
191
]
}
|
these results indicate that the uncoupling action of xanthomegnin on the respiratory system in mitochondria might involve ionic interaction of xanthomegnin with cationic residues in the hydrophobic region of mitochondrial membrane proteins .
|
NA
|
{
"id": "C0022023",
"name": "ionic",
"pos": [
122,
127
]
}
|
{
"id": "C0007447",
"name": "cationic",
"pos": [
161,
169
]
}
|
the regulatory properties of three key enzymes in the phenylalanine biosynthetic pathway , 3-deoxy-d-arabino-heptulosonate 7-phosphate synthetase ( dahp synthetase ) [ ec 4.1.2.15 ] , chorismate mutase [ ec 5.4.99.5 ] , and prephenate dehydratase [ prephenate hydro-lyase ( decarboxylating ) , ec 4.2.1.51 ] were compared in three phenylalanine-excreting mutants and the wild strain of brevibacterium flavum .
|
NA
|
{
"id": "C0008514",
"name": "chorismate mutase",
"pos": [
184,
201
]
}
|
{
"id": "C0033068",
"name": "prephenate hydro-lyase",
"pos": [
249,
271
]
}
|
when the ionic strength of solutions containing the enzyme and fdp was sufficiently low , one and two kinds of the sites could bind with fdp , converting the enzyme into pi 6.6-isozyme and pi 6.2-isozyme , respectively .
|
NA
|
{
"id": "C0014442",
"name": "enzyme",
"pos": [
52,
58
]
}
|
{
"id": "C0022173",
"name": "isozyme",
"pos": [
196,
203
]
}
|
the heavy chain of 6s myosin was also reactive with the antibody against the heavy chain of cardiac myosin .
|
NA
|
{
"id": "C0027100",
"name": "heavy chain",
"pos": [
4,
15
]
}
|
{
"id": "C0027096",
"name": "myosin",
"pos": [
100,
106
]
}
|
each of the inhibitors , designated hhv inhibitor ii and nnv inhibitor ii , consisted of 57 amino acid with arginine and glycine at the nh2- and cooh-termini , respectively .
|
NA
|
{
"id": "C0002520",
"name": "amino acid",
"pos": [
92,
102
]
}
|
{
"id": "C0017890",
"name": "glycine",
"pos": [
121,
128
]
}
|
these properties were very similar to those of clostridial hydrogenase [ ec 1.12.7.1 ] , in spite of differences in the acceptor specificity and subunit structure .
|
NA
|
{
"id": "C0020284",
"name": "hydrogenase",
"pos": [
59,
70
]
}
|
{
"id": "C0030016",
"name": "ec 1",
"pos": [
73,
77
]
}
|
when fully autoactivated , phosphorylase kinase possesses an activity that is 100 % higher than that of the protein kinase-activated form .
|
NA
|
{
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
27,
47
]
}
|
{
"id": "C0033640",
"name": "protein kinase",
"pos": [
108,
122
]
}
|
prior phosphorylation of phosphorylase kinase by the protein kinase has little effect on the level of autophosphorylation .
|
NA
|
{
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
25,
45
]
}
|
{
"id": "C0033640",
"name": "protein kinase",
"pos": [
53,
67
]
}
|
the purified enzyme was the major isoenzyme , which represented 60 % of cathepsin d present in porcine spleen .
|
NA
|
{
"id": "C0014442",
"name": "enzyme",
"pos": [
13,
19
]
}
|
{
"id": "C0022173",
"name": "isoenzyme",
"pos": [
34,
43
]
}
|
the diacylglycerol concentrations required for half-maximal velocity were 20 to 40 mum for long chain diacylglycerols and 2 to 3 mum for short chain diacylglycerols ;
|
NA
|
{
"id": "C0043791",
"name": "diacylglycerol",
"pos": [
4,
18
]
}
|
{
"id": "C0012262",
"name": "diacylglycerols",
"pos": [
149,
164
]
}
|
the half-regeneration times for albumin , however , are substantially greater than those obtained with smaller proteins that have fewer disulfide bonds .
|
NA
|
{
"id": "C0001924",
"name": "albumin",
"pos": [
32,
39
]
}
|
{
"id": "C0033684",
"name": "proteins",
"pos": [
111,
119
]
}
|
restricted populations of antibody to albumin were obtained by fractionating antisera to the native intact molecule on immunoadsorbents bearing these fragments .
|
NA
|
{
"id": "C0003241",
"name": "antibody",
"pos": [
26,
34
]
}
|
{
"id": "C0020960",
"name": "antisera",
"pos": [
77,
85
]
}
|
guanyl-5'-yl imidodiphosphate ( gpp ( nh ) p ) , gtp , and other purine nucleotides selectively decrease the binding affinity of the beta-adrenergic receptors of frog erythrocyte membranes for beta-adrenergic agonists but not antagonists .
|
NA
|
{
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
32,
44
]
}
|
{
"id": "C0018353",
"name": "gtp",
"pos": [
49,
52
]
}
|
enzyme activities with peaks only in the denser fractions included sodium and potassium ion-activated atpase ( ( na+ + k+ ) -atpase ) , adenylate cyclase , cyclic amp phosphodiesterase , beta-glucosidase , beta-galactosidase , and succinate-dependent cytochrome c reductase .
|
NA
|
{
"id": "C0001473",
"name": "atpase",
"pos": [
102,
108
]
}
|
{
"id": "C0001479",
"name": "na",
"pos": [
236,
238
]
}
|
analysis of sodium-22 binding to purified sodium + potassium ion-activated adenosine triphosphatase ( na+ , k+ ) -atpase reveals the presence of two classes of binding sites .
|
NA
|
{
"id": "C0001479",
"name": "sodium",
"pos": [
12,
18
]
}
|
{
"id": "C0001473",
"name": "atpase",
"pos": [
114,
120
]
}
|
a study was carried out of a therapy supporting the anaerobic glycolysis and coronary perfusion of ischemic myocardium and preserving its potassium and magnesium contents , which consisted in combined administration of hyaluronidase , glucose , insulin , tris , methoxamine , and potassium and magnesium aspartate .
|
NA
|
{
"id": "C0024467",
"name": "magnesium",
"pos": [
152,
161
]
}
|
{
"id": "C0543448",
"name": "magnesium aspartate",
"pos": [
294,
313
]
}
|
during secretion of the neurohypophysial hormones , oxytocin and vasopressin , secretory granule membrane is added to the plasma membrane of the axon terminals .
|
NA
|
{
"id": "C0032017",
"name": "neurohypophysial hormones",
"pos": [
24,
49
]
}
|
{
"id": "C0030095",
"name": "oxytocin",
"pos": [
52,
60
]
}
|
in order to determine whether these hybrid cells can function as germ cell precursors , these cells were transplanted to the posterior tip of genetically marked embryos .
|
NA
|
{
"id": "C0018956",
"name": "cell precursors",
"pos": [
70,
85
]
}
|
{
"id": "C0007634",
"name": "cells",
"pos": [
94,
99
]
}
|
similarity of nonhistone proteins in nuclear sap and chromatin , and essential absence of contractile proteins from mouse liver nuclei .
|
NA
|
{
"id": "C0033684",
"name": "proteins",
"pos": [
25,
33
]
}
|
{
"id": "C0009915",
"name": "contractile proteins",
"pos": [
90,
110
]
}
|
water-organic solvent mixtures , aqueous buffer solutions and organic and mineral acid solutions in both water and in aqueous-organic solvents have been used as eluents .
|
NA
|
{
"id": "C0043047",
"name": "water",
"pos": [
0,
5
]
}
|
{
"id": "C0026157",
"name": "mineral",
"pos": [
74,
81
]
}
|
ten different c18 , c19 , and c21 steroid sulfates and the corresponding unconjugated steroids were used as substrates .
|
NA
|
{
"id": "C0033006",
"name": "c21 steroid",
"pos": [
30,
41
]
}
|
{
"id": "C0038317",
"name": "steroids",
"pos": [
86,
94
]
}
|
to determine whether abnormalities in glucagon secretion might precede the onset of hyperglycemia in diabetes mellitus , 32 prediabetic pima ( american ) indians , 27 normal pima indians and 34 normal caucasians received an infusion of arginine monochloride ( 5 mg/kg/min for 40 minutes ) with measurement of glucose , insulin , and glucagon .
|
NA
|
{
"id": "C0011849",
"name": "diabetes mellitus",
"pos": [
101,
118
]
}
|
{
"id": "C0362046",
"name": "prediabetic",
"pos": [
124,
135
]
}
|
hypothalamic-pituitary function was investigated in 20 patients with craniopharyngioma , and all showed some degree of hypopituitarism .
|
NA
|
{
"id": "C0032002",
"name": "pituitary",
"pos": [
13,
22
]
}
|
{
"id": "C0020635",
"name": "hypopituitarism",
"pos": [
119,
134
]
}
|
these findings suggest that physiologic increases in serum rt3 concentration probably do not inhibit t4 to t3 conversion or the anterior pituitary tsh and prolactin responses to thyrotropin-releasing hormone ( trh ) .
|
NA
|
{
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
128,
146
]
}
|
{
"id": "C0040160",
"name": "thyrotropin",
"pos": [
178,
189
]
}
|
we have developed a rapid and simple indirect enzyme-labeled antibody procedure suitable for screening for antibodies to viral , bacterial , and parasitic antigens .
|
NA
|
{
"id": "C0003241",
"name": "antibody",
"pos": [
61,
69
]
}
|
{
"id": "C0003253",
"name": "antibodies",
"pos": [
107,
117
]
}
|
calcium absorption in 30-cm segments of small intestine was measured by constant perfusion of test solutions containing different concentrations of calcium gluconate .
|
NA
|
{
"id": "C0006675",
"name": "calcium",
"pos": [
0,
7
]
}
|
{
"id": "C0006699",
"name": "calcium",
"pos": [
148,
155
]
}
|
in contrast to 125i-insulin , the retention and degradation of two iodinated insulin analogues of relative low biological potency , proinsulin and desalanyl-desasparaginyl insulin , were small .
|
NA
|
{
"id": "C0033362",
"name": "proinsulin",
"pos": [
132,
142
]
}
|
{
"id": "C0021641",
"name": "insulin",
"pos": [
172,
179
]
}
|
in the normal subjects , after protein ingestion , there was a large amino acid release from the splanchnic bed predominantly involving the branched chain amino acids .
|
NA
|
{
"id": "C0002520",
"name": "amino acid",
"pos": [
69,
79
]
}
|
{
"id": "C0002521",
"name": "branched chain amino",
"pos": [
140,
160
]
}
|
large increments were seen in the arterial concentrations of the branched chain amino acids ( 100-200 % ) and to a smaller extent for other amino acids .
|
NA
|
{
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
65,
91
]
}
|
{
"id": "C0002520",
"name": "amino acids",
"pos": [
140,
151
]
}
|
leg exchange of most amino acids reverted from a basal net outut to a net uptake after protein feeding which was most marked for the branched chain amino acids .
|
NA
|
{
"id": "C0002520",
"name": "amino acids",
"pos": [
21,
32
]
}
|
{
"id": "C0002521",
"name": "branched chain amino acids",
"pos": [
133,
159
]
}
|
lysine infusion resulted in 16 % of the total response in yield of milk protein that was obtained with either the 10 essential amino acids or sodium caseinate while infusion of lysine and methionine together accounted for 43 % of the total response .
|
NA
|
{
"id": "C0002525",
"name": "essential amino",
"pos": [
117,
132
]
}
|
{
"id": "C0025646",
"name": "methionine",
"pos": [
188,
198
]
}
|
the antigenic and allergenic properties of phospholipase a2 ( pla2 ) and whole bee venom were compared by measuring the igg and ige antibody responses in animals and man .
|
NA
|
{
"id": "C0003320",
"name": "antigenic",
"pos": [
4,
13
]
}
|
{
"id": "C0002092",
"name": "allergenic",
"pos": [
18,
28
]
}
|
precipitating antibodies raised in rabbits and reaginic and other antibodies raised in mice reacted about equally with both bee venom and pla .
|
NA
|
{
"id": "C0034761",
"name": "reaginic",
"pos": [
47,
55
]
}
|
{
"id": "C0003241",
"name": "antibodies",
"pos": [
66,
76
]
}
|
these studies suggest that although pla is a major allergen and antigen in bee venom , significant exceptions in patients ' reactivity may limit its potential diagnostic and therapeutic usefulness .
|
NA
|
{
"id": "C0002092",
"name": "allergen",
"pos": [
51,
59
]
}
|
{
"id": "C0003320",
"name": "antigen",
"pos": [
64,
71
]
}
|
by utilizing the birefringence of the accumulations as a marker , it was determined that , unlike natural cholesterol and cholesterol esters , the striated material was resistant to acetone and ethanol extraction .
|
NA
|
{
"id": "C0008377",
"name": "cholesterol",
"pos": [
106,
117
]
}
|
{
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
122,
140
]
}
|
the method involved precipitation of properdin from human serum and subsequent passage through an immunoadsorbent column of sepharose anti-rp globulin which bound the contaminating proteins .
|
NA
|
{
"id": "C0017649",
"name": "globulin",
"pos": [
142,
150
]
}
|
{
"id": "C0033684",
"name": "proteins",
"pos": [
181,
189
]
}
|
thus , when t cell activity of lymph node cells from plasmacytoma-bearing mice was tested in vivo by sensitization with dinitrofluorobenzene and in vitro by responsiveness to phytohemmagglutinin , allogeneic cells , and dinitrobenzene sulfonate , cell-mediated immunity was found to be normal .
|
NA
|
{
"id": "C0007634",
"name": "cells",
"pos": [
42,
47
]
}
|
{
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
197,
213
]
}
|
thus , when t cell activity of lymph node cells from plasmacytoma-bearing mice was tested in vivo by sensitization with dinitrofluorobenzene and in vitro by responsiveness to phytohemmagglutinin , allogeneic cells , and dinitrobenzene sulfonate , cell-mediated immunity was found to be normal .
|
NA
|
{
"id": "C0012463",
"name": "dinitrofluorobenzene",
"pos": [
120,
140
]
}
|
{
"id": "C0012459",
"name": "dinitrobenzene",
"pos": [
220,
234
]
}
|
incubation of herpes simplex virus-infected human fibroblasts with the serum from a patient with herpes labialis rendered the cells susceptible to immune lysis by human mononuclear leukocytes ( mnl ) as well as complement .
|
NA
|
{
"id": "C0016030",
"name": "fibroblasts",
"pos": [
50,
61
]
}
|
{
"id": "C0007634",
"name": "cells",
"pos": [
126,
131
]
}
|
although there was no demonstrable loss of fatty acids , this conversion of lps to a polyanionic molecule altered dramatically the spectrum of biologic properties , most of which are normally attributed to the lipid a ( la ) moiety .
|
NA
|
{
"id": "C0023810",
"name": "lps",
"pos": [
76,
79
]
}
|
{
"id": "C0023767",
"name": "lipid a",
"pos": [
210,
217
]
}
|
neutralizing antibodies were demonstrated in blood samples drawn 58 days after the incident from five survivors who had received a full course of treatment , but such antibodies were absent from the blood of one untreated survivor ( who had only minor scratches and had refused treatment ) and of the wife of one man who died , who had been in close contact with her husband throughout his illness .
|
NA
|
{
"id": "C0475463",
"name": "neutralizing antibodies",
"pos": [
0,
23
]
}
|
{
"id": "C0003241",
"name": "antibodies",
"pos": [
167,
177
]
}
|
bacterial lipopolysaccharides extracted from bacteroides fragilis subspecies fragilis lacked 2-keto-3-deoxyoctonate and heptose , sugars which make up part of the inner core of most bacterial endotoxins .
|
NA
|
{
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
10,
29
]
}
|
{
"id": "C0014264",
"name": "bacterial endotoxins",
"pos": [
182,
202
]
}
|
over 98 % of the lipid portion of this material could be removed easily with chloroform-methanol and alcohol , a finding which indicates a loose association between the polysaccharide and lipid moieties .
|
NA
|
{
"id": "C0001963",
"name": "methanol",
"pos": [
88,
96
]
}
|
{
"id": "C0001962",
"name": "alcohol",
"pos": [
101,
108
]
}
|
the concentrations and distributions of major lipids ( cholesterol , phospholipid , and triglyceride ) , tocopherol and carotenoids were determined in the plasma lipoprotein fractions ( vldl , ldl , and hdl ) of ( 1 ) normal human subjects , ( 2 ) patients with hyperlipoproteinemia , and ( 3 ) patients with erythropoietic protoporphyria treated with oral beta-carotene and/or alpha-tocopherol .
|
NA
|
{
"id": "C0023779",
"name": "lipids",
"pos": [
46,
52
]
}
|
{
"id": "C0023820",
"name": "lipoprotein",
"pos": [
267,
278
]
}
|
the concentrations and distributions of major lipids ( cholesterol , phospholipid , and triglyceride ) , tocopherol and carotenoids were determined in the plasma lipoprotein fractions ( vldl , ldl , and hdl ) of ( 1 ) normal human subjects , ( 2 ) patients with hyperlipoproteinemia , and ( 3 ) patients with erythropoietic protoporphyria treated with oral beta-carotene and/or alpha-tocopherol .
|
NA
|
{
"id": "C0007271",
"name": "carotenoids",
"pos": [
120,
131
]
}
|
{
"id": "C0053396",
"name": "beta-carotene",
"pos": [
357,
370
]
}
|
using quantitative data previously reported for the penetration of local anesthetics into lecithin monolayers , the effects of surface and subphase concentrations of anesthetics on the inhibition of pancreatic phospholipase a2 action on didecanoyl phosphatidylcholine monolayers was investigated .
|
NA
|
{
"id": "C0031617",
"name": "lecithin",
"pos": [
90,
98
]
}
|
{
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
248,
267
]
}
|
maximal rate of hydrolysis was achieved in the presence of much smaller quantities of activator than the lipoprotein particles were capable of binding , and chylomicrons were fully activated for triclyceride hydrolysis in the presence of only 10 % plasma for triglyceride concentrations of up to 3 mg/ml .
|
NA
|
{
"id": "C0023820",
"name": "lipoprotein",
"pos": [
105,
116
]
}
|
{
"id": "C0008731",
"name": "chylomicrons",
"pos": [
157,
169
]
}
|
such features are the treppe phenomenon and captured beats in escape rhythm , fixed coupling intervals in extrasystoles , partial or complete atrioventricular block in very premature atrial extrasystoles , prolongation of the period following an atrial extrasystole , interpolated premature beats , complete compensatory pause and the rule of bigeminy in ventricular extrasystoles , slight instability of the parasystolic period , multiple length parasystolic periods slightly different from the exact multiples of the parasystolic idioperiod , preference of the parasystoles for certain phase in the sinus cycle , synchronization at a phase difference and fluctuation repeatedly and without interruption from a parasystolic to an extrasystolic rhythm and synchronization in escape rhythm with isorrhythmic dissociation .
|
NA
|
{
"id": "C0033036",
"name": "atrial extrasystole",
"pos": [
183,
202
]
}
|
{
"id": "C0340464",
"name": "premature beats",
"pos": [
281,
296
]
}
|
such features are the treppe phenomenon and captured beats in escape rhythm , fixed coupling intervals in extrasystoles , partial or complete atrioventricular block in very premature atrial extrasystoles , prolongation of the period following an atrial extrasystole , interpolated premature beats , complete compensatory pause and the rule of bigeminy in ventricular extrasystoles , slight instability of the parasystolic period , multiple length parasystolic periods slightly different from the exact multiples of the parasystolic idioperiod , preference of the parasystoles for certain phase in the sinus cycle , synchronization at a phase difference and fluctuation repeatedly and without interruption from a parasystolic to an extrasystolic rhythm and synchronization in escape rhythm with isorrhythmic dissociation .
|
NA
|
{
"id": "C0340464",
"name": "premature beats",
"pos": [
281,
296
]
}
|
{
"id": "C0151636",
"name": "ventricular",
"pos": [
355,
366
]
}
|
one patient had suffered a recent anterior myocardial infarction and developed the arrhythmia during rapid pacing for atrial flutter , when the electrode catheter had inadvertently entered the right ventricle .
|
NA
|
{
"id": "C0003811",
"name": "arrhythmia",
"pos": [
83,
93
]
}
|
{
"id": "C0004239",
"name": "atrial flutter",
"pos": [
118,
132
]
}
|
recovery of pituitary secretion of gonadotrophins and prolactin during re-feeding after chronic restricted feeding in female rats .
|
NA
|
{
"id": "C0018066",
"name": "pituitary",
"pos": [
12,
21
]
}
|
{
"id": "C0033371",
"name": "prolactin",
"pos": [
54,
63
]
}
|
both guanosine 5'-triphosphate ( gtp ) and 5'-guanylylimidodiphosphate ( gpp ( nh ) p ) activated adenylate cyclase ( ec4.6.1.1 ) in chick kidney plasma membranes .
|
NA
|
{
"id": "C0018353",
"name": "guanosine",
"pos": [
5,
14
]
}
|
{
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
73,
85
]
}
|
the maximum increases in adenylate cyclase activity produced by gtp and gpp ( nh ) p were respectively 130 and 720 % over basal activity .
|
NA
|
{
"id": "C0018353",
"name": "gtp",
"pos": [
64,
67
]
}
|
{
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
72,
84
]
}
|
gtp and guanosine 5'-diphosphate inhibited the activation of adenylate cyclase by gpp ( nh ) p , suggesting that they all acted at a common site .
|
NA
|
{
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
}
|
{
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
82,
94
]
}
|
embryonic tissues from the 12th day to the end of gestation were examined for isoenzyme transitions , and it was found that the adult forms of these enzymes appeared during gestation .
|
NA
|
{
"id": "C0022173",
"name": "isoenzyme",
"pos": [
78,
87
]
}
|
{
"id": "C0014442",
"name": "enzymes",
"pos": [
149,
156
]
}
|
the proteins were obtained in two soluble fractions : a concentrate of proteins from the cytosol was obtained by homogenization in a hypotonic medium and another fraction constituting membrane-associated proteins was solubilized by detergent treatment of the residual pellet ;
|
NA
|
{
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
}
|
{
"id": "C0025252",
"name": "membrane-associated proteins",
"pos": [
184,
212
]
}
|
erythrocyte calcium content increases from 15-20 to 120-150 nmol/g hemoglobin after incubation for 2 h at 20 degree c in a 400 mosmol/kg , ph 7.8 solution containing 100 mm sodium chloride , 90 mm tetramethylammonium chloride , 1 mm potassium chloride , and 10 mm calcium chloride .
|
NA
|
{
"id": "C0006675",
"name": "calcium",
"pos": [
12,
19
]
}
|
{
"id": "C0006686",
"name": "calcium",
"pos": [
264,
271
]
}
|
this was not due to a 'curing ' effect of the fatty acids but was the result of greater sensitivity of the growth of bacteria containing penicillinase plasmid to inhibition by the unsaturated fatty acids .
|
NA
|
{
"id": "C0015684",
"name": "fatty acids",
"pos": [
46,
57
]
}
|
{
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
180,
203
]
}
|
infection of human embryonic fibroblast cell monolayers with neutral red and light-inactivated herpes simplex virus , type 2 ( hsv-2 ) at supra-optimal temperature ( 42 degrees c ) resulted in persistence of viable cells in suspension culture at 37 degrees c which have properties in common with virus transformed cells : formation of cell aggregates , hsv-2-specific antigens and colony formation in soft methyl cellulose medium .
|
NA
|
{
"id": "C0016030",
"name": "fibroblast cell",
"pos": [
29,
44
]
}
|
{
"id": "C0007634",
"name": "cell",
"pos": [
413,
417
]
}
|
severity of head injury ( post-traumatic amnesia duration ) was related to poor memory , as was increasing age , but both persisting neurological signs , including dysphasia , and skull fracture were not .
|
NA
|
{
"id": "C0018674",
"name": "of head injury",
"pos": [
9,
23
]
}
|
{
"id": "C0037304",
"name": "skull fracture",
"pos": [
180,
194
]
}
|
both animals disposed of free or food-derived amino acids more rapidly than could be accounted for by catabolism alone , but the transient increases in turtle plasma concentrations consisted mostly of essential amino acids , whereas the alligator plasma showed little increase in essential amino acids and considerable rises in four nonessential amino acids , glutamine , glutamic acid , glycine and alanine .
|
NA
|
{
"id": "C0002520",
"name": "amino acids",
"pos": [
46,
57
]
}
|
{
"id": "C0017890",
"name": "glycine",
"pos": [
388,
395
]
}
|
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