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next generation environmentally friendly intraband active colloidal quantum dots and their ultrafast carrier dynamics for mid infrared photodetector
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infrared technology has found widespread applications across various fields including remote controls telecommunications networks and thermal imaging etc traditional semiconductor alloys like indium gallium arsenide mercury cadmium telluride and indium antimonide have been commonly employed as active materials in infrared devices however the manufacturing and assembly processes for these materials are highly complex and costly to overcome these challenges and potentially replace expensive epitaxially fabricated devices colloidal quantum dots cqds have emerged as a promising alternative in contemporary scientific exploration there has been a surge of interest in narrow bandgap cqds thanks to their remarkable capacity to finely adjust excitonic transitions within the midwave infrared midir spectrum the discovery of intraband transition 1seh1peh has opened as an alternative source of narrow energy transition occurs in the quantized conductionvalence band states of cqds numerous research groups have extensively investigated the fundamental aspects and practical applications of hge where e s se and te cqdsleveraging numerous recent scientific breakthroughs in the domain of intraband 1se1pe active colloidal quantum dots we will integrate stateoftheart material processing techniques across chemistry physics and engineering we will assess the dynamics of charge carriers through the utilization of femtosecond midir transient absorption spectroscopy in addition we will focus on optimizing the required surface environment capable of maintaining intraband transitions under ambient conditions at the same time offering adequate optoelectronic properties mobility conductivity for their implementation in photodetector devices ultimately our objective is to produce midir photodetector devices incorporating the highly compatible non toxic ag2se and coreshell cqds
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federated network of platforms for passenger and freight intermodality
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growing challenges are identified during the last years in both passenger and freight mobility such as urbanization trends the increasing complexity of stakeholder scene ecommerce rising fragmentation of freight transport despite the various technical challenges and shortcomings current governance and regulatory systems have proven so far inadequate dealing with the passengers and freight transport systems as independent and thus disconnected sectors while integration between passenger and freight transport has been a subject of debate in the transport community over the last years with a peak coming after the recent covid19 crisis delphi focuses on the strategic dimension of integrating passenger and freight transport in a single system aiming to deliver the enablers both on technical and governanceregulatory level towards a federated network of platforms for multimodal passenger and freight transport capable of sharing in a seamless and secure manner crosssectoral multimodal passenger and freight transport data as well as traffic management systems information moreover delphi will utilise novel and ultraefficient methodologies for traffic monitoring such as uaspowered monitoring multiintermodal optimisation aimlpowered algorithms and frameworks and will exploit diverse modes for hybrid passenger and freight transport in different ecosystem types to achieve its maximum potential utmost interoperability and best optimisation results delphis digital framework and transversal tools will be validated in the context of 4 pilots with complementary requirements and features
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femtosecond laser writing for photonic quantum processors
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ephos is a photonic quantum computing company our objective is to build the key element of the infrastructure to power quantum computing photonic chips ephos has a unique asset to reach this goal it is the only photonic quantum startup in the world with inhouse chip manufacturing capabilities we build our glassbased photonic quantum processors using a femtosecond laser writing flw process developed by our founding team our fabrication process with respect to those of our competitors is faster has lowercost higher flexibility and is capable of working with 3d structures the resulting chips have low interface losses which makes them the ideal building blocks of the modular architectures that are the leading contender to deliver scalable quantum computationthe aim of the current project is to support ephos in establishing the worlds most advanced flw facility for the production of quantum photonic chips over the course of this project we will build the largest programmable quantum photonic processor in the market this project will enable the development of more powerful and efficient quantum computing technologies that have the potential to revolutionize various industries the lowercost and higher flexibility of ephos fabrication process could potentially make quantum computing more accessible for a wider range of organizations and researchers
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magnetic nanographenes synthesis and characterisation of structurally defined nanographene fragments containing paramagnetic metal ions
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the development of tailored nanomaterials for quantum technologies is urgently neededcurrently polydisperse materials such as conducting polymers graphene nanoribbons carbon nanotubes etc lead the research field of organic electronics while nondiscrete systems based on inorganic solids as nitrogenvacancy centers in diamond or certain defects in si are ahead in most applications in nanotechnology these areas of research progress towards the creation of smaller and more functional devices promoting the invention of more and more sophisticated methods to control them one of the main barriers of this evolution is the lack of materials that offer reproducibility and scalability as well as stability and functionality with that regard molecular materials provide promising prospects due to their defined chemical structure high processability and because they can be tuned in a rational way by chemical designthe preparation of molecular materials containing magnetic functionality spin centers and the ability to transport electrons a conjugated organic framework is still very limited due to the lack of synthetic protocols even though graphene is the most popular platform for organic electronics and magnetism the insertion of spin centers in graphenelike materials has been scarcely explored in this project i aim to develop an efficient protocol for the preparation of hybrid nanographenes that compete with nondiscrete materials
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nonlinear excitation of ideal anapoles
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anapoles are nonradiating states of light in which optical fields are trapped by destructive interference of outgoing radiation they have recently attracted significant interest due to their potential in resonant nanoscale light confinement which could be used in lasers sensors quantum computers and other areas of lightbased research and technology however ideal anapoles have never been experimentally achieved because making them perfectly decoupled from external radiation would prevent their excitation and observation the proposed project will resolve the above issues advanced theoretical modeling tools will be used to design the ideal anapoles that can be excited through secondharmonic generation in this process the incident light would illuminate the anapolar nanoresonators and nonlinearly induce local optical fields matching the anapoles excitation at twice the incident light frequency secondharmonic optical fields may form configurations that can not be induced through linear interactions with external optical fields hence allowing these local fields to be fully decoupled from external radiation these local nonradiating fields will then induce photoluminescence at optical wavelengths detuned from the anapoles resonance detecting this photoluminescence will enable probing the anapole excitation to demonstrate this concept in experiments resonant photonic samples will be fabricated in the silicon nitride si3n4 material platform integrated with molibdenium disulfide mos2 monolayers which can simultaneously support efficient secondharmonic generation and photoluminescence the samples will be excited by timecontrolled ultrashort laser pulses enabling investigation of the temporal dynamics of the anapoles local optical fields and retrieving their q factors demonstration of the ideal anapoles is an ambitious and challenging goal with breakthrough potential for the research on confined states of light and their possible applications
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health simulations ethical and societal challenges of digital twins
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digitisation has an impact on even the most fundamental concepts in medicine and public health including our ideas of health and illness embodiment vulnerability and controllability among the emerging technologies driving this paradigm shift is that of digital twins dt which presents exceptional challenges to healthcare governance raising ethical and societal issues of which our understanding is still rudimentary dt may be empowering but could also exacerbate the vulnerability of both individual patients and the population at large there are substantial gaps in our understanding of whether these new forms of artificial intelligencedriven health simulations provide new ways of engaging with experiences of human vulnerability or whether they in fact introduce new forms of harm in this context simtwin will be the first project systematically identifying and examining the ethical and societal implications of the use of dt in healthcare in doing so simtwin will promote our understanding of and practical approaches to new forms of simulation and prediction of health trajectories simtwins central objective is to provide a comprehensive and indepth analysis of the normative challenges implied in order to develop an integrated theory of health simulations in proposing an empiricallybased and normatively robust framework for an ethical and societal assessment of this technology simtwin will enable the design of practical modes of controllability for the use of dt in healthat a moment in history in which our societies find themselves facing crucial decisions on how to approach the complex issues raised by the dual simultaneously transformative and disruptive character of health simulations simtwin promises groundbreaking insights into the associated normative and societal challenges and key orientations for a robust and innovative governance framework
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era chair for accelerated synthetic chemistry technologies at palack university olomouc
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to unite a powerful potential of two outstanding research leaders and thus capitalize on their mutual collaboration for reaching the impact none of them would achieve on their own this is the aim of the accelerator project it brings together 1 the worldrenowned professor of chemistry inventor and innovator alexander dömling as an era chair of the synthetic group and 2 the czech advanced technology and research institute catrin of palack university olomouc up merging three excellent research centres into a unique scientific ecosystembetter links between ri actors across european research area era and beyond is a must if europe is to maximize excellence from across the continent up has been pursuing this goal for a long time now to become a pocket of excellence and an advanced research trendsetter up needs to yet i enhance the excellence and strengthen its position in era ii streamline the ri commercialization system and establish new industrial partnerships and iii foster brain circulation to attract outstanding scientistsso far unconquered issue of automation in synthetic chemistry innovative compoundbased wholeplantscreening technologies for securing food supply novel antibacterials addressing the challenge of increasing antimicrobial resistance and breakthrough materials for batteries and supercapacitors enabling energy storage from renewable sources are just few challenges awaiting to be solved by the accelerator the project that has all prerequisites to rise the era chairs expected impact to its fullnessproject will lead to 1 the increase of the ups research excellence 2 institutional changes at up through strengthening the innovation knowledge transfer ecosystem in olomouc region 3 improved capability of up to successfully compete in international research funding 4 securing the longterm sustainability of the synthetic chemistry research group after the completion of the project
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deep labelfree cell imaging of liquid biopsies for cancer monitoring
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we will develop and commercialize an innovative device for diagnosis and monitoring of cancer in liquid biopsies based on a labelfree interferometric phase microscopy ipm unit coupled with dedicated realtime artificial intelligence ai for cell classification this device will materialize an innovative approach for the muchanticipated imaging flow cytometry dramatically decreasing its costs and improving patient care by accurate monitoring of cancer in the clinical lab from a simple lab test liquid biopsy the success of the project is dependent on four highriskhighgain aspects a building the first clinical ipm device b designing and manufacturing a disposable microfluidic device for imaging flow cytometry c obtaining highenough acquisition and processing throughput in imaging flow cytometry of urine samples d training a deep natural network to detect cancer cells based on the informationdeep labelfree ipm images of cancer cells during flow the proposed poc project stems from my ongoing erc stg project that focuses on the application of ipm for grading the metastatic potential of cancer cells as a basicscience research tool
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healthy ship 4u
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hs4u offers an evidencebased approach extending standardized design and regulatory paradigms towards industry 50 the project is promoting principles of modularization optimization and smart systems engineering towards the detection prevention mitigation and management of large passenger and cruise ships hence hs4u holistic solutions for stress relief over conditions of health crises prioritize the assessment of typical cruise designs and daytoday tasks following its two use cases celestyal and columbia blue and its 4unique pillars approach for research ie1societalhuman 2environmental 3technological 3legislation factors it adopts and delivers stateofthe art ecosystem of technologies offering groundwork to rethink health and safety designs and frameworks hs4u bridges crosssectorial multidisciplinary expertise to crossfertilize research findings and provide best practices protocolpolicy recommendation and a complete solution for crew training based on multiplayer gaming validation of proposed technology and passenger behavioral model will be based on live experiments special hs4us open sourcefair offerings arecollaborative digital framework cdf for live interaction of crewpassengers and iot edge devices on the ship based on corobotics concepts and artificial intelligence mechanisms and models viral detection sensor vds that will be developed tested validated delivered patented and commercialized to offer online indication of the location of pathogenic airborne spreads in indoor environmentsrobotcabin reallife demonstrator displaying evidencebased 4u solutions on the interoperability of smart and innovative methods for ship systems effective and fast detection prevention mitigation and intercompartment intracompartment management ensuring healthy ship operations and safe return to port over conditions of health crises
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brightspace designing a roadmap for effective and sustainable strategies for assessing and addressing the challenges of eu agriculture to navigate within a safe and just operating space
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the european green deal aims among others to increase the contribution of eu agriculture to climate change action improve the management of natural resources ensure a fair economic return for farmers and reinforce the protection of biodiversity eu agriculture and food practices are currently not on the right track to meet the green deal ambitions and objectives these objectives are interdependent and while often aligned they may also compete synergies and tradeoffs between socioeconomic and environmental outcomes are brought together in the concept of a safe and just operating space sjos where the safe component reflects the biophysical boundaries of the ecosystem and the just component the requirements for the wellbeing of the involved people policy makers and opinion leaders often lack sufficient information to gauge the likely effects of a sjos crises in their country the brightspace collaboration responds to this challenge by designing effective and sustainable strategies to navigate within a sjos brightspace provides an analytical toolbox to experiment analyse and coordinate the effects of innovative technologies governance structures as well as short and longterm policies related to agriculture thereby allowing for the execution of consistent coherent and lasting strategies with the desired consequences the project emphasises the diversity of challenges regarding the sjos across countries and regions and delivers new empirical evidence on causeeffect relations between drivers and outcomes relevant for the sjos a harmonised data framework and modelling toolbox are developed for mediumterm and forwardlooking projections of possible sjos futures by 2050 and beyond the support for effective and sustainable actions will include the identification of critical pathways for technological institutional and consumeroriented options for eu policies in the areas of agriculture climate change trade and energy
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hydrogenelectric zero emission propulsion system
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herops aims to introduce climateneutral propulsion into regional aircraft by developing mtus flying fuel cell ffc propulsion system concept for entry into service in 2035 this disruptive hydrogenelectric propulsion system uses fuel cells as sole power source and a liquid hydrogen fuel system without the need for highpower batteries integration of both the fuel cell system and the electric propulsion unit into a compact engine nacelle will ensure an efficient system at high powertoweight ratio herops targets to demonstrate a 12 mw propulsion system based on a scalable 600 kw core module at trl4 the core module and all further subsystems will be validated up to trl5 complemented by simulation and electrical network testing of the overall modularised system scalability to the 2 4 mw power level will be confirmed the certification programme will build upon ongoing certification activities enabling timely maturation of the aviationnative herops technology against relevant certification requirements the twophase approach of the overall programme including extensive development test and validation cycles at each stage is expected to advance the ffc concept to trl6 for integration and demonstration on a regional aircraft by 2028 it will pave the way for commercial prototyping and entryintoservice by 2035 delivering a key propulsion technology to reach the european green deals objective of climateneutral aviation by 2050 with 100 prevention of co2 and nox emissions and up to 80 reduction of the climate impact from contrails and contrail cirrus the herops project will meet this challenge with a european consortium of aircraft propulsion system integrators electrical system experts key tier 1 suppliers and leading researchers in stack technology mechanics and propulsion leveraging relevant and effective synergies between european and national programmes
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high performance organic narrowband emitters for stable blue oleds
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constricted by electron spin statistics the maximum internal quantum efficiency of 100 can be achieved in organic lightemitting diodes oleds by utilizing purely organic thermally activated delayed fluorescence tadf materials however due to strong charge transfer they exhibit broad emission with a fullwidthathalf maximum fwhm 70 nm recently multiresonant tadf mrtadf emitters a subclass of tadf materials based on alternating boron and nitrogen atoms embedded into polycyclic aromatic hydrocarbon scaffolds are attracting much interest in oleds their key attributes include a narrow fwhm high photoluminescence quantum yield and unprecedented color purity even though these mr materials have advantages in color purity over conventional tadf materials their device stability is weak and results in a poor operational lifetime lt due to the large singlettriplet energy gap delayed fluorescence lifetime and too slow rate of reverse intersystem crossing risc especially narrowband blue oleds lt 100h is still inferior to the conventional tadf oleds the honesty project seeks to address the above issues by rationally designing organic narrowband novel tadf emitters our designs comprised four types a combination of boron and nonboron targeting a high risc rate leading to highly stable narrowband blue oleds with long lt among the four types one design includes yet unexplored rigid telluriumbased acceptor decorated with high triplet energy donors which is keen for new tadf scaffolds the rigidity of all chemical components with slightly twisted confirmation and aryl groups on donors will work coherently to furnish highly stable oleds with suppressed efficiency rolloff improved device stability and long lt overall the honesty proposal is anticipated to provide a breakthrough in stable blue narrowband tadfoleds with the supervision of karolis kazlauskas a physics expert in stable oleds working at vilnius university lithuania
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modified gravity from compact objects to dark energy
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the origin of the accelerated expansion of the universe remains elusive the socalled dark energy might be a manifestation of modified gravity at very large scales while nearfuture observatories will improve the current bounds on such a possibility they will not likely be conclusive as to its nature an opportunity arises from the study of modifications of gravity at shorter scales specifically around compact objects like black holes and neutron stars recently made possible through gravitationalwave observationsthis project aims to dramatically improve the constraints on cosmological modifications of gravity by means of an interdisciplinary approach involving tools from high energy physics and both astrophysical gravitationalwave and cosmological observations modified gravity dynamics at different scales can be described in a modelindependent way as effective field theories according to symmetry principles strong constraints will come from a combined theoretical and phenomenological study within this framework both analytical and numerical tools will be developed and employed to qualitatively and quantitatively compute the expected signatures on gravitationalwave astrophysics allowing to hold these models against observations the constraints will then be translated to the cosmological modifications of gravity drawing novel conclusions as to which theories can consistently explain dark energy while satisfying bounds across a large range of scalesultimately this project will foster the collaboration among the high energy physics cosmology and gravitationalwave astrophysics communities enabling a much faster and efficient progress in the field of modified gravity in general this includes a more focused use of the available computational resources for timeconsuming resourceintensive tasksthe multifaceted training and support received during the action and the competences acquired are aimed at the career development of the fellow
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detecting epigenetic biomarkers in the blood for noninvasive precision oncology
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the detection of circulating tumor dna allows to noninvasively retrieve tumor molecular profiles and follow disease evolution these approaches promise optimal and individualized management of patients with cancer however despite remarkable progress several technological obstacles still limit liquid biopsy widespread application indeed detecting small fractions of tumor dna released when the tumor burden is reduced remains a challenge samples collected at early stages or during treatment may contain less than one mutant copy per milliliter of plasma which is below the detection limit of current technologies moreover detectable recurrent mutations do not cover all patients it is therefore necessary to develop new more sensitive but also more informative tools my goal is to develop new methods detecting epigenetic markers from peripheral blood for establishing more efficient noninvasive diagnostic tests and disease monitoring targeting the cancer epigenome which contains a myriad of somatic alterations that do not modify the dna sequence and cover cases without detectable mutations will achieve increased sensitivity these markers could become decisive in detecting residual disease and early stages of multiple forms of cancer i will develop approaches to 1 analyze circulating dna methylation profiles at unique and repeated sequences 2 identify circulating dna cells of origin using nucleosome footprint 3 analyze transcripts associated with circulating extracellular vesicles ultimately a single test integrating dna methylation profiles fragmentation patterns and evassociated transcripts from the same plasma sample will be developedthis project has both fundamental and biomedical implications it will generate indepth knowledge of the biology of circulating nongenetic tumor biomarkers and lead to the development of more efficient noninvasive diagnostic tests adapted to all types of cancers based on the universality of these factors
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radical chemistry with the hydrogen atom through water activation
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water activation which allows the transfer of universally abundant hydrogen into value added compounds is an important research field in modern science this task has been realized mainly by using transitionmetalbased systems herein we will use a conceptually novel mild water activation strategy which proceeds through a photocatalytic phosphinemediated radical process the active species in these processes is a metalfree r3poh2 radical cation intermediate where both hydrogen atoms are used in the following chemical transformation through sequential heterolytic h and homolytic h cleavage of the two oh bonds the r3poh radical intermediate provides an ideal platform to mimic the reactivity of a free hydrogen atom that can be directly transferred to various systems to give hadduct cradicals which are eventually reduced by a thiol cocatalyst leading to overall transfer hydrogenation of systems with the two hatoms of water ending up in the product the driving force is the strong po bond formed in the phosphine oxide byproducthydrogenation of alkenes arenes and heteroarenes will be investigated also addressing stereoselective reductions using chiral hdonors deuteration and tritiation with d2o and t2o as formal reductants will be explored experimental studies will be supported by dft calculations throughout the studies polar effects exerted by the hdonors will be studied which will allow the design of more complex intramolecular and intermolecular reductive cascade reactions comprising cc bond forming steps reactivity of the novel r3poh radicals towards various functionalities will be systematically investigated and the reactive functional groups then incorporated into cascade reactions atomeconomic radical htransfer isomerization reactions that proceed with pbased catalysts will be developed finally photoactive pcompounds will be used as mediators for water activation in hydrogen atom transfer radical chemistry
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rethinking the design of streets and public spaces to leverage the modal shift to climatefriendly active transport everywhere
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drastic decrease in transport emissions of 55 by 2030 and 90 by 2050 is required for european cities to reach climate neutrality this is hindered by inconvenient mobility infrastructure inadequate services and insufficient governance for shortdistance travel negatively impacting active modes safety and security reallocates main objective is to pave the way towards climateneutral safe inclusive and smart european cities through integrated and innovative sustainable urban mobility solutions that will address the needs of diverse groups and communities while rebalancing street space allocation the project will empower 10 twinned mission cities gothenburgtampere heidelbergutrecht lyonwarsaw budapestzagreb barcelonabologna by providing horizontal thematic expertise supporting them to build a local innovation ecosystem to develop and deploy zeroemission shared inclusive active and humancentred mobility interventions pilots in 15 urban and periurban unsafe areas will demonstrate innovative urban space management and reallocation strategies for sustainable modes with a specific focus on active modes having in mind safety inclusivity affordability and a just transition to climate neutrality overall solutions include innovative urban design behavioural nudging smart technological and datadriven solutions to reduce actual and perceived road safety risks all contributing to achieving climate neutrality by 2030 the pilots will be the learning and testing environments for integrated approaches to foster knowledge transfer and collaborative learning to staff in cities through mentoring and capacity building knowledge exchange twinning and work shadowing the projects impact will be exponentially increased by engaging 10 cascade cities in capacity building activities and providing them with replication packages and guidelines resulting in implementation plans for replicating at least one of the innovative solutions piloted
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a biorefinery for upcycling coffee waste into sustainable healthy highvalue ingredients
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kaffe bueno has developed an innovative model for upcycling coffee waste into highvalue ingredients coffee is highly bioactive with huge reservoirs of lipids melanoidins and phenols yet we currently use just 1 of its potential discarded coffee waste ends up in landfill producing methane and co2 or is reused as biofuel or compost kaffe bueno transforms this wasted resource into a business opportunity we produce high quality coffee oil melanoidins and ligninphenols as sustainable natural active ingredients sold b2b to manufacturers of cosmetics and personal care products helping denmark and the eu meet their targets for carbon reduction by 2030 we aim to valorise 100 of our coffee waste feedstock in this project kaffe bueno will build and optimise a demo biorefinery with the capacity to process 200 tons of coffee waste year using our efficient proprietary process then use equity to expand this plants capacity to 1200 tons and invest in r d for new applications
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opticallypumped magnetometer arrays for magnetoencephalography
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magnetoencephalography meg is a noninvasive imaging technique for investigating human brain function uniquely capable ofmeasuring brain activity with good spatial and temporal resolution meg operates by detecting magnetic fields naturally produced bythe brain with no applied fields or injections epilepsy diagnosis is the most advanced clinical application for meg six million peopleare affected by epilepsy in europe alone with about 300 000 new cases every year use cases for meg are growing for examplediagnosis of mild traumatic brain injuries tbi which represents more than half of the 25 million new tbi cases each year in europe clinical use of meg is at present limited to large hospitals and elite clinics due to space cost and the need for specialized cryogenics techniciansoptically pumped magnetometers opms are a cryogenfree quantum sensor technology with extraordinary magnetic sensitivityrelative to cryogenic methods opm provide a superior balance of sensitivity size and proximity to the cortex but have not yet beenimplemented in technologies that are simultaneously manufacturable at scale highperforming and costeffective opmmeg willdevelop an opm array that meets these requirements for widespread use of opms in meg and demonstrate its application tomagnetoencephalographythe project brings together world leaders in quantum sensor components and systems commercial meg systems and megapplications ompmeg will build a value chain from photonic devices to systems connecting all relevant stakeholders the consortiumis composed of 2 smes 2 worldclass research organizations and 1 university from 3 european countries the position of theseorganizations in their respective markets guarantees that the project results will be widely exploited providing the companies with atechnological advantage over their worldwide competitors thus creating new hightech jobs and technology leadership in europe
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quarcbeyond quantum advantage a practical and unconditional perspective
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in this project i will develop techniques and tools to demonstrate unconditional and practical quantum advantage the quantum speedups that have been developed so far are mostly based on certain assumptions from complexity theory or they are established relative to imaginary back boxes called oracles that are assumed to perform certain tasks and implement certain operations on input data i will design problems that can demonstrate quantum advantage without such assumptions the tools and techniques that will be developed in this project can have a wide range of applications in other disciplines in particular i will export tools and algorithms from theoretical quantum computation to more practically relevant applications in machine learning and cryptography i specify concrete objectives that address important gaps in the development of quantum advantage i design work packages to systematically implement my envisaged approaches and methods i will bring my expertise from quantum information and incorporate it in quantum effects and computation to reach my goals i clarify the role of the fellowship in my career development towards establishing my own research group i explain my approaches towards implementing this project in an impactful manner
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music that produces racial inequality the impact of racist ideas on the conditions of existence of afrodiasporic musicians in peru
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racism permeates the everyday musical practices of afroperuvian musicians impacting their living conditions across class gender and phenotype informed by a colonial racist framework peruvian musicians scholars and aficionados have historically conceptualized afroperuvian musical practices in terms of essentialist connections with africa and black bodies racial prejudices and colonial social hierarchies such racialization of afroperuvian musical practices entails that its practitioners must routinely address racist expectations and stereotypes and the way they do so has material and emotional consequences for themracismus analyzes how racist ideas about afroperuvian musical practices affect the living conditions of its practitioners as well as the strategies they employ to resist or mitigate such impacts drawing on scholarship in ethnomusicology historical musicology and critical race theory racismus objectives are to produce empirical knowledge about a the historical foundations of racist ideas that currently shape the artistic practice of afroperuvian music b how in shaping their practice those racist ideas impact the conditions of existence afroperuvian music practitioners across class gender and color in a context of racial inequality and mestizaje and c the agency of afroperuvian music practitioners in addressing those racist ideas and their impact in their practice including their decisionmaking processes strategies and resources
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feminist movements revitalizing democracy in europe
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fierce aims at providing sound theoretical and practical knowledge and tools to revitalize alliances between the feminist movement civil society and political decision makers in a context of growing social inequalities political disaffection and strengthening of populist radical right antigender actors and discourses the research uses an interdisciplinary multidimensional and multilevel framework that aims to overcome the limitations of both disciplinary scholarships and nationalist methodologies fierce develops indepth understanding of feminist and antifeministantigender movements activities and discourses and their impact on the institutional arena and on policy outcomes focusing on the period 20102021 these actors and especially the feminist movement will be studied through framing political ethnography and social network analyses on the background of key gender debates and controversies prefigured to be situated in the areas of labour market health and reproductive rights lgbtq rights migration and genderbased violence fierce will cover eight case studies france italy greece slovenia turkey denmark poland spain representing a wide variety of country contexts in sociopolitical geographical and welfare terms fierce moves beyond a countrybased approach and provides a crosscutting comparative analysis of the way debates and controversies on gender have influenced the dynamics and output of the policy process building on cocreation methods and on a strong alliance with civil society organisations fierce proposes pilot actions that can reinvigorate democratic practices in line with feminist inclusive visions for the future of democracy fierce thereby sets out a bottomup problemdriven and impactoriented approach bridging academic knowledge policymaking and bottomup democratic strategies
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anion exchange membrane water stack based on earth abundant 2d materials for green hydrogen production
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the baseline technology for green h2 production is the waterelectrolysis we however roughly 96 of the h2 produced today is from fossil fuels with the remaining 4 produced through water electrolysis due to the stillhigh costs and lower performance of current electrolysers compared with other production processes not affected by the use of toxic or critical raw materials crm therefore there is a need of boosting the development of highly active and efficient catalysts to turn green hydrogen into a viable solution to decarbonise different sectors and to meet the ambitious goals settled in the hydrogen strategythis project proposes an advanced anion exchange membrane water electrolyser aemwe stack as a critical milestone to translate the highly promising results coming from the groundbreaking research conducted during the ercstg awarded to dr g abelln into a marketable innovation the aemwe stack novelty relies on nontoxic crmfree breakthrough novel electrodes anodes made of twodimensional 2d nickeliron layered double hydroxide materials 2d nifeldhs that have shown an outstanding catalytic behaviour using this electrocatalytic material will allow overcoming the main challenges of we to produce green h2the activities to be undertaken under the 2d4h2 project are aimed to prepare the translation of the 2d nifeldhs electrocatalytic materials into an aemwe stack as a precursor of a future fully operational 05kw electrolyser for this purpose the necessary optimisation and characterisation of the electrocatalyst to enable the testing and validation in a pilot plant of the single unit cell and the aemwe stack prototype will be carried out together with the elaboration of an integrated strategy for effectively managing the knowledge generated during the project including clarifying the ipr position and an exploitation strategy involving potential stakeholders in order to evolve the idea further towards exploitation
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renewable and waste heat valorisation in industries via technologies for cooling production and energy harvesting
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the overarching aim of rewitch is to deliver costcompetitive gamechanging solutions in the field of sustainable industrial cooling and heating to do so rewitch will demonstrate advanced thermallydriven industrial cooling technologies based on adsorption and absorption processes driven by an optimized mix of lowgrade waste and renewable sources innovative high vacuum flat plate solar collectors such solutions will be demonstrated in 4 demo sites encompassing food and beverage sectors as well as industrial sectors where heattocold solutions are not yet widely explored biorefinery pharmaceutical the activity will be completed by studying the replicability of proposed technologies in replication sites even integrated with dhn the project will be delivered by an industrialdriven consortium of 26 partners from 10 countries and it is composed by some of the most innovative smes les and rd centers in the field of industrial renewable hc leveraging experience from industrial and eufunded projects hycool sowhat indus3es the multidisciplinary composition of the consortium ensures that all the challenges technical and non will be addressed to ultimately bring rewitch solutions to the market by 2029 innovative open access modelling platforms and engineering solutions will be also developed to facilitate the design upscale replication and integration in industrial processes of the proposed technologies thanks to a stakeholders driven dissemination and communication campaign rewitch will ultimately demonstrate transformative technological solutions that unlock the combined potential of lowgrade waste and renewable heat use in industries hence also targeting integration of heattocold technologies into relevant eu policies
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painful decisions how chronic pain affects daily decisionmaking
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fibromyalgia fm is a chronic pain syndrome characterized by widespread pain multiple tender points fatigue and impaired mental functioning best practice interventions for chronic pain typically include effortful exercise and longterm treatment ie shortterm costs effort with delayed benefit improved pain and function problematically adherence to these treatments is often low suggesting that people with chronic pain may have altered decisionmaking related to delayed and effortful rewards understanding if longterm pain influences decisionmaking what aspects of longterm pain contribute most to decisionmaking eg emotional versus physical and the neural underpinnings are essential given clear relevance of altered decisionmaking to the adherence to evidencebased management strategies the painful decisions paid project will address these critical aspects by evaluating delay and effort attitudes in those experiencing fm and in a group of matched painfree controls additionally i will investigate the unique role of emotions and bodily sensation perception as potential contributing factors to altered decisionmaking involving delayed and effortful gratification paid is a highly innovative and interdisciplinary project integrating approaches from experimental psychology behavioural economics clinical practice psychophysiology and neuroimaging this way i will be able to comprehensively investigate the role of bodybrain interactions in the context of chronic pain such a systematic selective and interdisciplinary approach to study decisionmaking in chronic pain is a considerable research challenge yet the results have an essential meaning for patients life and clinical practice offering to move basic and applied science forward
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strengthening the european chain of supply for next generation medical radionuclides
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secure project aims to make a major contribution to the sustainability of medical isotope production and its safe application in europe it is focusing on promising developments in the design of irradiation targets production routes for existing and new isotopes in nuclear therapy and diagnostics isotopes critical in the success of nuclear medicine are selected and research activities are identified to address some of the major challenges in securing its future availability with the objectives1to remove critical barriers along the production of its selected alpha and beta emitting isotopes that restrict a sustainable production 2to develop a framework of guidance and recommendations that enables exploring the full clinical potential of alpha and beta particle therapy and its safe application 3to provide important lessons learned that act as a demonstration case for addressing issues in upscaling and sustained isotope productionat present ra223 is the only radiopharmaceutical which has been granted marketing authorization to treat adults with prostate cancer this has paved the way for a wider use of other alpha emitters such as ac225 or bi213 the expected demand of nuclear medicine for novel alpha emitters and beta emitters requires reevaluation of their production methods and inventories of target materials and parent radionuclides the ambition of secure consortium is to identify and efficiently use the current resources for new radionuclides in particular for alpha emitters and the relevant beta emitting theranostic radionuclides the development of alternative technologies for production of such therapeutic radionuclides for improved patient treatment requires multidisciplinary scientific and technological knowledge including physics chemistry material science machining of target materials chemistry biology and radiobiology radiopharmacy and nuclear medicine all this chain of expertise is present in secure consortium
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glycotwinning building networks to excel in glycosciences
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glycoscience is a multidisciplinary research area focusing on the role of glycans in health and disease the field is expanding rapidly worldwide driving innovation in biomedical sciences and becoming an essential part of modern science including medicine and providing bases for understanding human diseases and tools for personalized medicine glycotwinning is a capacitybuilding network with the ambitious goal to provide a breakthrough in the research of the applied biomolecular sciences unit nova university lisbon ucibionova from chemistry to microbiology immunology and biomedicineto achieve excellence ucibionova needs further synergies to be acquired through networking with topclass partners imperial lumc and cicbiogune glycotwinning will i promote scientific excellence and innovation in glycoscience ii empower researchers capacity and creativity iii strengthen research management and administration skills iv raise dissemination activities v boost reputation research profile and attractivenessglycotwinning brings synergy and multidisciplinarity in cuttingedge scientific methodologies glycan microarrays advanced electrophoresis highresolution mass spectrometry and nuclear magnetic resonance to decode sugar recognition by glycanbinding proteins involved in disease through glycotwinning ucibionova will reinforce its research capacity expanding its current rdi profile to dissect glycanprotein interactions from the atomic and molecular levels to the cellular context boosting the development of innovative glycanbased tools diagnosis and therapies furthermore glycotwinning will integrate its objectives in a project that explores glycanprotein interactions of the human microbiome in colorectal cancer validating a glycotwinning toolbox creating new knowledge innovation and opening new research avenues for the widest dissemination and exploitation with long term scientific and societal impact
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innovative solutions to eliminate domestic abuse
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the iseda project innovative solutions to eliminate domestic abuse aims to combat and eliminate dv by employing an enriched european approach utilizing modern technological tools and practices and improved multisectoral expertise in its activities one of them is developing a chatbot which will employ empathetic language and inform victims on ways to get help and assistance as well as refer them to hotline numbers police or other first responders to deescalate violent situations the chatbot will also familiarize citizens with the different types of dv how to prevent detect and investigate it with victims consent an integrated data platform will gather courtproof evidence to be used to build a legal case and record trends on the nature frequency and circumstances of the dv a key activity of the iseda project will be providing training to primarily pas through interactive learning participants will develop the necessary skills to better assess dv situations respond accordingly and provide better assistance to victims and a just treatment to their casesawareness on dv will be further improved through campaigns integrating victims input via informational guides posters and videos education programs will focus on sensitizing and engaging students fostering knowhow on deconstructing toxic gender stereotypes and gbv and promoting healthy relationships and zero tolerance to violence the iseda project will also promote and implement perpetrator programs as an alternative to imprisonment and a chance for positive change as such programs have the potential to significantly increase the quality of life of both victims and perpetratorsoverall the iseda project employing multidisciplinary expertise and addressing the different aspects of dv has the potential to significantly enhance the fight against dv on a european level and contribute to the establishment of the necessary robust longlasting structures to eliminate it
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exploration of the biosynthetic potential of the secondary metabolome of the newly identified fungal endophyte cyanodermella asteris
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in the proposed research i aim to explore the secondary metabolome of the newly identified fungal endophyte cyanodermella asteris in this regard we have selected two in silicopredicted polyketide synthase gene clusters which will be further examined the selected gene clusters thereof are chosen for vector construction in escherichia coli and subsequently the heterologous expression in fungal hosts aspergillus niger or aspergillus nidulans will be performed afterwards the engineered expression strains will be examined in a combined effort applying mass spectrometry and nuclear magnetic resonance experiments to identify the newly produced compounds additional metabolomicsbased tools and molecular networking will be employed moreover the biosynthetic pathways of the isolated natural products of the respective gene clusters will be fully delineated
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tumourhost interactions in liver cancer of childhood and adults
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liver cancer is a major health problem with 1 million cases diagnosed each year 90000 casesyear in europe and it is the 3rd cause of cancerrelated mortality worldwide hepatocellular carcinoma hcc in adults and hepatoblastoma hb in children are considered poorly understood cancers hcc is a difficulttocure cancer curation rate 30 with poor outcome median survival 2 years in advanced stages due to limited understanding of atrisk populations resistance to therapies and lack of precision oncology in hb outcomes are hampered in one fourth of cases due disease progression after surgical intervention and adjuvant chemotherapy thrive aims by to improve the outcome of both paediatric and adult liver cancer patients by understanding atrisk populations tumourhost interactions and by developing biomarkers for current therapies and novel affordable treatments to overcome resistance thrive brings together a strong multidisciplinary team 13 partners from 8 countries with complementary expertise to leverage cuttingedge technologies singlecell rnaseq spatial transcriptomics microbiota analysis artificial intelligence mouse models and patientderived organoids and sectors ie academia smes hospitals patient associations and 15 patient cohorts 6700 samplesthrive expects to 1 define molecular features of cancer predisposition and atrisk populations for development of liver cancer 2 develop a complete human liver cancer blueprint of tumour immune stromal cells and intratumoral microbiomes 3 identify aibased and molecular markers of response to treatments 4 implement a preclinical drug testing platform for discovery of affordable therapies with high social impact 5 maximize the impact in the european society by integrating ssh disciplines delivering accessible and reusable data and tools to support eu initiatives such as the uncaneu platform and by influencing policymakers and health professionalsthis action is part of the cancer mission cluster of projects on understanding tumourhost interactions
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genetically engineering experimental models enhancement of scientific and technological excellence and innovation potential to study neurodevelopmental diseases
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acibadem mehmet ali aydinlar university acu is a thematic university in the field of health sciences in turkey gemstone will advance acus scientific research and innovative capacity in strategic areas of gene engineering technologies and neuroscience with focus on the neurodevelopmental aspects of brain disorders such as parkinsons disease and epilepsy gemstone will strengthen collaboration with and capitalizing on knowledge transfer from one highranking foreign european academic institution ulund and one nonprofit organisation icons gemstone will create opportunities for bilateral exchange of scientific knowledge and technical skills and training opportunities for researchers in hard and soft skills supported by naturally convergent research interests the project will result in increased scientific productivity more active participation of acu in nationalinternational conferences and grants and new networking and collaboration opportunities which will increase the attractiveness competitiveness and visibility of acu within the global neuroscience community a second pillar in the project will ensure that acu researchers are adequately supported to express their potential staff of acu research project office and other research support services will be provided with the necessary knowledge and skills to guide researchers in submitting successful grant applications attracting funds communication research results and translating them to clinics andor in commercial products lessons learned in the performance of research and in research management and administration will be collected in a best practice book and disseminated to other universities and governments in widening countries ultimately by increasing acu researchers scientific profile and acu research management administration and communication capacities the project will decrease the disparities among acu and the topclass leading counterparts at the european level
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listening to change acoustic monitoring of multitrophic community dynamics in the face of increasingly variable and extreme environmental conditions
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species are often predicted to lag behind the unprecedented pace of ecological changes imposed by current human activities such changes result not only in modification of the mean environmental values in an ecosystem but also in increasingly extreme and variable environmental conditions these extreme and variable conditions operate at fine spatiotemporal scales a mechanistic understanding of these dynamics in response to new environmental conditions thus requires monitoring analysing and modelling at such fine spatiotemporal resolution passive acoustic monitoring pam is a rapidly growing field of research that allows for an unparalleled temporal resolution and a wide taxonomic diversity of sound producing species in terrestrial and aquatic environments in this context i will use pam to understand fine scale spatiotemporal community dynamics in response to increasingly extreme and variable environmental conditions for that i plan to develop a methodological and conceptual framework to understand community dynamics at unprecedented spatiotemporal resolution first i will use unsupervised learning to characterise acoustic community composition creating acoustic groups that i will ecologically identify i will then use these groups to assess spatiotemporal variation of community composition in these environments and their associations using network models finally i will use different change scenarios to investigate the potential impact of these changes on community dynamics this research will increase our understanding of the importance of extreme and variable environmental conditions in driving community dynamics
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analysing of fossilenergy dependence in agriculture to increase resilience against input price fluctuations
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the recent variations in the price of fossil fuels and mineral fertilisers in the wake of the covid19 pandemic and the russian invasion of ukraine threaten the incomes of primary producers and affordability of food for consumers this threat will remain as the pathway towards fossil fuel independence and related investments in less fossilfuelintensive technologies in the eu agricultural sector will take time all this shows that there is an urgent need to design realistic sustainable pathways for supporting the energy transition of the european agricultural sector and improving the income of primary producers agenres designs sustainable pathways for policy making to reduce direct and indirect dependence of farmers and the agricultural sector as a whole on fossil fuels and fertilisers and increase the resilience to volatile energy prices taking into account farmers behaviour and the synergies and tradeoffs between european economic and environmental objectives at micro and macrolevel our approach consists of three components supported by outreach activities which involve stakeholders and the general public throughout the projects lifespan the first component develops a conceptual and data framework to identify policy targets and measures promising technologies and data and model requirements component one results among others in an eu wide database on energy use and mitigation potentials at different scales the second component focuses on evidence of the past and present energy dependence of the european agricultural sector and preferred solutions the third component builds on the first two and incorporates them into a set of foresight models at farm regional and market levels to evaluate the impacts of innovations and policy measures and targets at different scales ultimately agenres develops an innovative toolbox that will decrease the energy dependence and strengthen the resilience of the european agricultural sector
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elucidation of risk factors and health determinants associated with progression of monoclonal gammopathies to multiple myeloma
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multiple myeloma is a chronic malignancy characterized by slow progression and recurrences currently there is no effective cure since eventually the disease develops resistance to all the available therapeutic approaches although recent advances have expanded our understanding of the cellular functions associated with health to disease transition recurrence and response to therapy critical aspects of this complex pathology remain to be elucidated application of omics technologies and bioinformatics approaches on highly annotated samples obtained from all informative states monoclonal gammopathy of undetermined significance mgus smoldering mm smm active mm mm could identify biological pathways and molecules responsible for the onset progression and resistance to therapy of multiple myeloma in parallel particular emphasis will be given to elucidating the health determinants and risk factors associated with progression to active mm from mgussmm by using extensive demographic lifestyle and exposure datasets mgus is present in 35 of the ageing european population and every year 1 progress to incurable mm that imposes a significant burden on eu societies and health systems thus the best chances of curing mm may be in preventing its progression in the first place moreover there is need of experimental models that recapitulate myeloma progressionwe propose an interdisciplinary approach bringing together clinicians and researchers aiming to integrate epidemiological clinical and experimental datasets in order to create a molecular model of cellular processes associated with the onset of active mm and response to therapy the proposed systems medicine approach could yield clinically actionable molecular features that could improve mm patient management moreover the integration of lifestyle clinical and omics information will provide specific profiles for each patient allowingpersonalized diagnosis prevention and therapeutic approachesthis action is part of the cancer mission cluster of projects on understanding
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gradient clock synchronization for networksonchip and cellular networks
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in large distributed computing systems there is a big performance advantage when all communication can be carried out synchronouslycurrent synchronization techniques result in long communication latencies as the systems scale up in size and operating frequency we identify two key application areas in which this is an immediate and pressing challenge1 large networksonchip nocs do not operate synchronously despite the relative ease of design and lowlatency communication this would offer2 despite issues of security and availability current cellphone networks rely on global navigation satellite systems gnss such as gps to obtain tightly synchronized timewe propose the application of gradient clock synchronization gcs as a novel clock synchronization method for these applicationsgcs minimizes the time offset between closeby parts of the systemthis results in much smaller offsets between such parts than standard techniques that aim at minimizing the maximum global offset onlygiven that in the above application settings it is the offset between closeby parts that matters this enables us to achieve large improvements in performancein particular we can eliminate the issues faced by noc designs and cellphone networks that we pointed out abovethe main objectives of the proposed poc project itself can be stated as follows development fabrication and evaluation of an asic demonstrator for soc and noc clocking development and evaluation of a secure wireless implementation of the gcs algorithm patent protection of the generated intellectual property finding industrial pilot partners for development of products in followup projects
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ultrafast chemical analysis imaging with raman
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most diseases including cancers viral infections neurodegenerative conditions cardiovascular and musculoskeletal disorders all originate from a molecular level disruption of the biological cell lifecycle each year the cost to the eu is ca 19 million lives and ca 200 billion in health care informal care and productivity loss for cancers alone current live cell imaging tools can only provide a limited view of the in vivo and in vitro microenvironments where diseases originate and grow the result is a gap in our understanding of the biochemical cellular makeup and how their disturbance leads to disease by increasing accuracy and speed of imaging and analysis the gap can be closed allowing novel medical treatments and diagnostics tailored to patients specific conditions ucair brings successful rd photonics smes research laboratories in optics and cell biology and worldleading microscopists and clinicians to create an innovative versatile practical multimodal photonics platform that will enhance and speed up the way cells are examined by scientists and healthcare professionals ucair will achieve breakthrough results by developing a laser platform that inventively combines nonlinear optical fibers optronics wideband coherent raman and artificial intelligence technologies to image at video rates and track cells and biological tissues with augmented chemometric digitalisation the new coherent light sources will be suitable for fundamental research microscopes and microfluidic channels but also in medical imaging instruments encompassing a value chain for new biomarker discoveries and translation into medical endoscopy for example during cystoscopy and resection of bladder cancer technology progression to trl 6 will allow first mover advantage with sustainable supply chain in this way ucair sustains the european leadership in photonics to deliver continuous innovation and outstanding benefits for its economy and the health of its population
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nonstandard data and image processing from nonlinear optics to quantum computing
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the optiq project is focused on nonstandard data and image processing methods which will lead to advances in quantum computing qc the project is designed as a platform for collaboration of academia silesian university of technology in poland research austrian institute of technology and security business austria and industry boson energy from luxemburg lg nexera from vienna and envelo from warsaw in a common purpose to achieve beyond stateoftheart progress in applications of quantum optics phenomena for quantum communication and computation in particular for quantum image processing and security the deployment potential of these latter applications will be exploited by boson energy in green energy sector and by envelo in digital secure communication respectively through common implementation of an ambitious research programme the project will generate novel skills for all consortium participants interdisciplinary and intersectoral staff training will serve as a basis for technology transfer and knowledge sharing between participants leading to elaboration and implementation of desired solutions in this way the project will strengthen collaboration between beneficiaries in quantum computing and communication qcc and in optical image processing oip in particular the consortium will focus on technology of entangled photons production and its application to qbit building quantum security quantum blockchain technology and quantum communication to facilitate contact with quantum optics an augmented reality aided simulator designer of optical quantum setups will be also developed particular attention will be paid to wide and efficient dissemination and communication due to these measures optiq project will strengthen career perspectives of participating scientists become the foundation for lasting collaborations in exploitation of results and increase competitiveness of european research area and industry on the worlds qcc scene
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relooking at statutory rape laws in malaysia psychosocial characteristics of sexual relations among underage and adultchild partners sexual motives and perception of the criminal justice personnel
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statutory rape laws are designed to protect children from the manipulation of adults into having sexual intercourse however in malaysia statutory rape laws are applied even on male adolescents who are close in age with their female partners this is problematic because applying these laws into male children will criminalize their normative sexual behaviors which has longlasting damaging effects in addition the perception of the criminal justice personnel on sexual behaviors of children also cements the blanket applications of statutory rape laws onto every case involving female children to reform the use of statutory rape laws in malaysia data on the sexual relations between closeinage partners and adultchild partners are needed this study has three research objectives first i aim to explore the perception of the criminal justice system personnel ie prosecutors police officers and probation officers towards the implementation of statutory rape laws on adolescents in malaysia second i would like to investigate the psychosocial characteristics sexual and antisocial dimensions of sexual relations involving two closeinage children in comparison with sexual relations involving adults and children lastly i aim to explore the psychosocialcultural motivations behind the pursuance of sexual relationships among asian adolescents the design of the proposed study will be a mixed design employing both quantitative to achieve research objective 2 and qualitative to achieve research objective 1 and 3 for the quantitative part of the study a hypothesis will be tested which is closeinage sexual partners differ in terms of psychosocial characteristics compared to adultchild sexual partners this will be tested using a binary logistic regression then i will employ a thematic analysis to find out the patterns from the responses the findings of this project will be disseminated through two journal articles and a conference attendance
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combined ai and data solutions for large scale resource optimization with green deal impact
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with the objectives of the green deal in mind cosmic aims to provide it systems that address largescale energy resource optimization challenges by leveraging ai and data solutions it will foster collaboration between small and large companies to create industrial ecosystems focused on key applications with the potential for substantial and escalable impactcosmics ecosystems are composed by 1 largeindustries facilitating big datasets and largescale pilots 2 core technical partners providing transversaltosector technical solutions 3 smes and startups bringing specific dataai based assets through open callsthe project will offer a set of dataai based platforms solutions and modules as transversal core infrastructures able to accommodate external it assets third parties mainly smes and startups will bring these assets in the form of dataai based services and solutions that are specificto an energy resources optimization key applications the integration of these core and applicationoriented technologies will result in a set of integrated ai systems iais for key energy resource optimization applications capable to scaleup to cover more key applicationscosmic will test these systems in 14 largescale pilots in 5 countries spain belgium portugal france and finland and at european level together with the validation of enduser and final beneficiaries acceptance of socialscience methodsto foster replicability a package will be offer including the lessons learned and recommendations for future adoption including suggestions for feasible winwin industrial partnerships and guidance on ecosystems sustainabilitythese ambitious objectives will be realized by a consortium of experienced and highly complementary partners from both research institutions industrial partners public authorities and ngos from eight european countries
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remote nmr rnmr moving nmr infrastructures to remote access capabilities
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nuclear magnetic resonance spectroscopy nmr is one of the major analytical methods applied in all chemical physical biological and medical sciences nmrs leading role stems from its analytical power in terms of molecular resolution quantification reproducibility and broad application envelope it requires sophisticated and expensive equipment operated by scientists with diverse background ranging from serviceoriented researchers to highly trained experts the aggregated capital investment in european nmr facilities operating at local national and european level exceeds 500 million euro the nmr community maintains excellent networking between sites and serves a broad community within the focal points of european research interestswith the application remotenmr rnmr we wish to establish remote access for all nmr users throughout europe while routine nmr applications are routine in every university and in industry more specialized applications are performed in dedicated research infrastructures offering access and help to local and outside users during the pandemic nmr infrastructures slowed down their operations to variable degrees and particularly access by remote users dropped significantly raising the need to establish standardized procedures for remote access to improve their resilience to adverse external factors in this proposal an inclusive network of nmrinfrastructures throughout europe will be established surveying if and how remote access can be made possible according to the needs of the community and implementing gdpr at facilities and sample shipment procedures routines for remote nmrusage will be established including dissemination of research and teaching protocols archiving of data and sample shipment the overall co2 footprint of the operation of the consortium will be evaluated as well as its reduction due to the reduction of travels
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university parissaclay interdisciplinary doctoral programme in sciences of light
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lightinparis is a msca cofund doctoral programme in the field of sciences of light aiming at promoting interdisciplinaryinternational and intersectoral research projects at university parissaclay upsaclay the sciences of light cover a very broad fieldfrom fundamental physics to technological applications in photonics quantum mechanics and biomedicine and open up anincreasing number of technological applications among these sciences photonics is one of the key enabling technologies identifiedin the horizon europe strategic planthe parissaclay region has been hosting numerous prestigious research laboratories for several decades to gather its strengthsupsaclay has been created in 2020 by grouping several academic and research institutions located in saclay area it joins 8100researchers working in 275 laboratories upsaclay was ranked 15th in the 2023 shanghai university ranking and 3rd in physics 1st ineurope in the global ranking of academic subjectsregarding sciences of light upsaclay gathers 700 researchers working in 28 laboratories across 5 graduate schools upsaclaygraduates every year 150 engineers and 70 phds specialized in optics in addition upsaclay hosts many world class research facilitiesthe institute for the sciences of light isl has been created in 2020 to foster interdisciplinary synergies among the graduate schoolsof physics chemistry engineering geosciences and life sciences and promote international and intersectoral relationsthe lightinparis programme through isl will recruit 30 phd fellows 2 cohorts of 36 months each industrial and international secondments will also be implemented to allow phd fellows to shape their careers by acquiring technical skills and networking relationships numerous trainings will also be offered to ensure that doctoral students have both technical skills and soft skills by the end of their phd
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european cohorts of patients and schools to advance response to epidemics
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the eucare project gathers a comprehensive multidisciplinary team of clinicians virologists epidemiologists statisticians and top experts in artificial intelligence to unveil the impact of sarscov2 variants on key sectors of public health as addressed by the call the specific activities include1the assessment of natural and artificial immunity to the different viral variants in health care workers with the aim of defining the crossimmunization patterns and the risk of vaccine escape informing vaccination strategies for the general population 2the analysis of the clinical course and longterm followup of hospitalized covid19 patients to derive the role of different viral variants in the outcome of the infection including postacute sequelae of sarscov2 infection 3the definition of the best strategies to control the spread of different viral variants in schools by comparing the outcome of diverse containment and prevention measures in relation to the prevalence and dynamics of the variants to ensure a suitable representativeness of the different variants vaccines and preventive measures eucare has secured the appropriate cohorts from diverse geographic areas including european countries kenya mexico russia and vietnam and will consolidate or expand interactions with other cohorts to deal with complex interactions among many variables including large dimensional parameters eucare harnesses the power of artificial intelligence to define the role of viral variants and inform clinical guidelines and prevention measuresin the longerterm eucare is committed to maintain active cooperation beyond the duration of the project with a dedicated task in the project the solid it and ethics infrastructure and the harmonised research procedures will make the cohort and laboratory network rapidly available to tackle newly emerging infectious diseases thus contributing to pandemic preparedness on a global scale
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federated data sharing and analysis for social utility
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availability of large volumes of user data combined with tailored statistical analysis present a unique opportunity for organizations across the spectrum to adapt and finetune their services according to individual needs having shown remarkable results in analyzing user data machine learning models attracted global adulation and are applied in a plethora of applications including medical diagnostics pattern recognition and threat intelligence however such service improvements and personalization based on user data analysis come at the heavy cost of privacy loss furthermore practice showed that systems that use such models incorporate proxies that are often inexact biased and often unfair in harpocrates we focus on setting the foundations of digitally blind evaluation systems that will by design eliminate proxies such as geography gender race and others and eventually have a tangible impact on building fairer democratic and unbiased societies to do so we plan to design several practical cryptographic schemes functional encryption and hybrid homomorphic encryption for analyzing data in a privacypreserving way besides processing statistical data in a privacypreserving way we also aim to enable a richer more balanced and comprehensive approach where data analytics and cryptography go hand in hand with a shift towards increased privacy in harpocrates we will first show how to effectively combine cryptography with the principles of differential privacy to secure and privatise databases next we will build privacypreserving machine learning models able to classify encrypted data by performing high accuracy predictions directly on ciphertexts across federated data spaces finally to demonstrate how these solutions respond to users needs we will implement two realworld crossborder data sharing scenarios related to health data analysis for sleep medicine and threat intelligence for local authorities
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human communication as joint epistemic engineering
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imagine ordering a drink at a diner pointing at an empty glass as an attentive waiter passes by how did you select that particular gesture and how could the waiter possibly interpret it as you intended as any other signal we use to communicate daily that gesture is highly ambiguous outside its context of use how can human communication work by using referentially flexible and contextually dependent signals mindsharing argues that interlocutors are communicatively effective because they jointly control their interactionspecific shared contextmindsharing integrates computational developmental and cognitive neuroscience to understand how that control is algorithmically defined culturally acquired and neurally implementedfirst using contextsensitive neural networks mindsharing identifies communicative control parameters during interactive multiturn linguistic and nonverbal referential games then assesses the value of those parameters as potential communicative universals across worldwide cultures second using prospective longitudinal studies mindsharing identifies the sociocultural experiences that influence the acquisition of communicative abilities during ontogenetic development third using concurrent brain stimulation and imaging in communicating dyads mindsharing tracks and perturbs the neural dynamics of communicative control parameters as dyads continuously adjust their shared context to novel communicative challengesmindsharing provides a novel causal account of a foundational element of human society the ability to communicate with referentially flexible signals mindsharing brings computational cultural and neurocognitive explanations into the interpersonal space where communication is used and where it is learned mindsharing will deliver what existing accounts have not delivered yet multilevel causal explanations of the multilevel human ability to communicate with referentially flexible and contextually dependent signals
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communication in ancient anatolia
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the project addresses the question of messages modes and participants in the communication of three anatolian cultures lydians luwians and phrygians ca 1200546 bce living in adjacent territories they were verifiably in contact with one another they are normally studied in isolation by different academic subjects leading to missed intercultural references and interconnections and preventing the reconstruction of a comprehensive picture the three cultures their interesting and diverse text sources their relationships with one another and their disunity as cultural entities are currently underresearched and only parts of their text corpora are available in modern editions the project will be the first to study both internal and external sources from other ancient near eastern and classical texts together using a combined semiotic and narratological approach examining text structure processes of meaningmaking communication and transmission texts and their material supports not only generate and exchange meaning they also preserve information on communication processes in the context of specific realms reading these texts with a focus on narrative and discourse will allow a new insight into formative parameters of ancient societies especially values cognitive patterns and the needs and motifs of the participants this marks a huge shift from traditional eventbased readings towards an analysis of belief and behaviour the project will be groundbreaking in its application and adaption of concepts from semiotics and narratology which were developed for the study of the modern world and have never before been applied to the study of these ancient texts the project will draw a new picture of cultural clusters and their parameters and provide new data for understanding ancient and modern identities and the potential of cultural differences its novel insight into communication can be extended to other ancient world studies
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plasma membrane probes for photocontrolled release of signaling molecules
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the cell plasma membrane pm of eukaryotic cells is a highly dynamic structure which plays important role in diverse biological processes such as cellular uptake neural communication muscle contraction and cell trafficking and signaling the pms are also responsible for communication between cells especially between neurons in particular the exocytosis process leads to liberation of neurotransmitters and neuromodulators on the other hand it is a platform for receptors that convert the recognition of neuroactive molecules into ion flux andor action potential therefore to modulate and monitor the activity of neurons an attractive approach is to design molecular tools that target cell pms in this project we will combine pmtargeting anchors with photoactive fluorescent cages capable to photorelease signaling molecules the obtained chemical tools memcages will be applied for 1 imaging the neuronal organization and 2 photocontrolled activation of neurons and brain of mice by photouncaging of signaling molecules close to pm the work is composed of 3 steps first is synthesis of memcages for dopamine and glutamate and their validation in solvents and model lipid membranes second is application of memcages in cellular systems which includes imaging and photostimulation of model cancer cell lines and neurons the first step will be in vivo validation of memcages which will be done during the secondment the applicant and the host laboratory plan extensive twoway knowledge transfer the applicant will gain knowledge and expertise in membrane probe design bioimaging in model membranes cells and animals whereas he will provide his expertise on design and characterization of molecular photocages for signaling molecules the successful utility of the developed chemical tools could open new avenues for the biologists and neuroscientists working in the field of cell signaling neuroscience and diagnosis and prevention of neurological disorders
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holography and topological semimetals
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weyl semimetals wsms are a recently discovered class of materials featuring an exotic array of properties with potential applications including the building of novel electronic devices the electrons in some wsms interact strongly with one another making their theoretical study challenging one tool for modelling strongly interacting systems is holography also known as the antide sitterconformal field theory correspondence holography has been used to model wsms before but there are open problems to do with holographically describing important features of real wsms in this project i will develop a new generation of holographic models and techniques capable of addressing several of these problems1 the effects of imperfections in a wsms crystal structure on its electronic properties particularly when the imperfections cause the electrons experiencing an effective curved spacetime2 certain nontrivial physics that occurs at the boundaries of wsms partly arising due to their topological properties3 holographically modelling a wsm with equations that are invariant under time reversal as is the case for the equations describing many real wsmsthe project will be carried out at nordita a joint department of stockholm university su and kth royal institute of technology the supervisor alexander krikun is an expert in holographic approaches to condensed matter physics through the research and training in the project i will obtain new skills such as numerical techniques for solving boundary value problems in partial differential equations su and kth both have condensed matter theory groups researching wsms from which i will gain expertise in nonholographic methods the project includes a secondment at instituto de fsica tericacsicuam in madrid with a group with expertise in anomalous transport an important aspect of wsm physics this secondment will support the research and training and foster new international collaborations
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sustainable federation of research infrastructures for scalingup experimentation in 6g
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6g is expected to emerge as key enabler for the intelligent digital society of 2030 and beyond providing superior performance via groundbreaking access technologies such as joint communication and sensing cellfree radio intelligent surfaces and ubiquitous wireless intelligence most importantly 6g is expected to trigger a total rethink of network architecture design which builds on the key idea of new stakeholders entering into the value chain of future networks the sunrise6g approach is inspired by the network of networks concept of 6g networks aiming to integrate all private and public infrastructures under a massively scalable internetlike architecture sunrise6g similarly aspires to create a federation of 6g test infrastructures in a paneuropean facility that will support converged testing as a service taas workflows and tools a unified catalogue of 6g enablers publicly accessible by experimenters and crossdomain vertical application onboarding experimentation and vertical application onboarding are offered via a tenant web portal that acts as a singleentry point to the facility serving end users eg experimenters and tenants eg vertical developers infrastructure owners 6g component manufactures the project execution is based on 4 pillars delivering a the implementation of new 6g enablers complementary to existing ones being developed in sns phase 1 projects b a truly scalable and 3gpp compliant federation solution that provides access to heterogeneous resources and devices from all europe c a federated ai plane aligned with aiaas and mlops paradigms which promotes a collaborative approach to ai research which benefits immensely from scalingup datasets and models and d a commonly adopted experimentation plane which offers common workflows to experimenters
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study of molecular events triggering the cytosolic enrichment of sumo activating enzyme and its implications in seed quality
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posttranslational modifications by sumo small ubiquitinlike modifier modulate protein activity through regulation of subcellular localization protein activity and stability and proteinprotein interactions in plants sumo is essential during seed development modulates hormone signaling and bioticabiotic stress responses several studies point to a nuclear enrichment of sumo conjugation machinery which is consistent with a preferential nuclear localization of the sumo targets nonetheless nonnuclear targets exist and the molecular mechanisms that mediate their modification remain elusive dr loiss group has uncovered a novel regulatory mechanism consisting of the processing of the cterminus of the sumo e1activating enzyme large subunit sae2 processed sae2 partially localize to the cytosol and the processing activity is prominent at the transition between embryo growth and seed maturation accumulation of sae2 in the cytosol promotes cytosolic sumoylation and behave as a signal for growth arrest suggesting that sae2 processing could contribute to finalising embryogenesis sumocell aims to uncover the signals that trigger sae2 cytosolic localization and the cellular responses activated by cytosolic sumoylation first with duke university partner we will study sae2 subcellular dynamics using superresolution microscopy under hormone treatments and stress challenges second we will study the physiological processes regulated by sae2 localization to the cytosol for that we will perform singlecell rnaseq studies from cells enriched in cytosolic sae2 bioinformatics analysis will be carried out by a placement at sequentia sl finally we will analyse physiological parameters related to seed quality data obtained from cell studies transcriptomics and seed performance will be integrated in a signalling model to understand the role of cytosolic sumo conjugation in seed development providing a multidisciplinar training program
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molecular design of electrically conductive covalent organic frameworks as efficient electrodes for lithiumion batteries
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a major breakthrough in chemistry and materials science has been the development of lithiumion batteries libs which show great potential for storing energy from renewable sources and as the power sources for electric cars however commercially available libs are based on transition metal oxide cathodes presenting limited energy density and raising relevant environmental concerns organic materials have received much attention as alternative electrodes because of their high theoretical capacity resources availability and sustainability in particular covalent organic frameworks cofs have emerged in the past few years as promising organic electrode materials due to their high stability high ionic conductivity and outstanding chemical and structural versatility low electrical conductivity remains the main bottleneck for real applications of cofs as electrode materials usually addressed by adding in large amounts of conductive carbon additives that decrease the energy density of the battery the overarching objective of this project is to design and synthesize new conductive redoxactive cofs as cathode materials to enhance libs electrochemical performance the specific goals are a to design a new family of stable redoxactive cofs built from unexplored building blocks to achieve an optimal balance between capacity electrical conductivity and porosity b to investigate the role of the linkages building blocks doping pressure anisotropy and morphology on the electrical conductivity unravelling the fundamental mechanisms of charge transport in cofs c to manufacture and test lithium batteries using conductive cofs cathode materials assessing the influence of the processing techniques on the electrochemical performance
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new carbohydrate oxidising enzymes prepared by directed evolution and their application in synthesis of aminoglycoside derivatives with antibiotic potential and rare sugars
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carbohydrateoxidising enzymes coe are a group of enzymes which are active on specific carbohydrates and can use molecular oxygen as a mild oxidant oxidation is typically directed towards specific positions of the sugar ring regioselectivity and substrate specificity relies on the architecture of active site therefore the direct evolution approach in this project will allow to generate a toolbox of effective and regiospecific catalysts to modify various carbohydrate scaffolds our aim is to use this toolbox to generate a library of bioactive compounds i aminoglycoside derivatives starting with analogues of kanamycin as candidates to help in the fight against the global problem of antimicrobial resistance this process in combination with a further chemical step may lead to a large library of derivatives prepared in short time with only a twostep chemoenzymatic process ii rare monosaccharides and oligosaccharides as promising candidates with health benefits antimicrobial activities of prepared library of compounds will be measured and statistically evaluated furthermore this project will advance the current knowledge of coe which is of utmost interest for fundamental biology and crucial for industrial biotechnology and chemistry applications biocatalysis will be applicable to the synthesis of a wide range of saccharide related compounds solving one of the big challenges in carbohydrate chemistry the regioselective differentiation of the oh groups in a green sustainable and very efficient way
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how migration decisions are made diverse aspirations trajectories and policy effects
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the eu and its member states pursue a wide range of policies that address migration including development cooperation border management and legal labour market access to be effective policies must be based on an accurate understanding of how individuals decide whether to migrate dynamig will fill critical gaps in scientific and policymakers knowledge about how the decisionmaking behaviour of potential and actual migrants interacts with policies given micro meso and macro factors eg different socioeconomic status we focus on africa as the most important future region of origin for migrants to europe we pursue a multidisciplinary approach along four dimensions first we extend existing conceptualisations of the dynamics of migration decisions along extended trajectories and test these through innovative methods including digital diaries collected from migrants en route from nigeria kenya senegal and morocco to europe second we develop a mobiledevicebased tool for online choice experiments to causally study aspiration formation across different contexts and stages of migration with several tens of thousands of individuals in origin and transit countries third we study how policies affect migration decisionmaking with methods that allow causal interpretation choice experiments with respondents in different contexts a randomised controlled trial of an entrepreneurship training intervention in senegal and a quasiexperimental analysis of the eutf for africa fourth through interviews with highlevel policymakers and textual analysis of policy documents we analyse how the design of eu member state and relevant african policies that address migration takes into account migrant decisionmaking to maximise our impact on policymaking we embed our research in an intentional process of joint knowledge creation with stakeholders in europe and africa including the policymaking community migrant and diaspora organisations and civil society
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biobone bioactive hydrogelbased implants to induce bone regeneration
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osteosarcoma and ewing sarcoma are the most common types of cancer in patients younger than 30 years the gold standard treatment is bone tumor resection followed by reconstruction of the tissue thereby allowing the salvage of the limb titanium and its alloys are mostly used in such orthopedic surgeries due to their biocompatibility and excellent mechanical properties a novel cuttingedge technology of patientspecific implants 3dimensional 3d printed porous titanium implants was recently introduced to clinical use yet even several years after surgery the resected section is not fully reconstructed leading to further medical complications often requiring reoperations a promising solution is the combination of titanium porous implants with bioactive scaffolds to support bone regeneration following tumor resection here we aim to fabricate a 3dprinted porous titanium implant incorporated with patentprotected bioactive materials we have developed in the scope of the personalbone ercstg project to provide an optimal microenvironment for stimulating bone regeneration following bone tumor resection for this purpose we will optimize the formulation as well as the method of incorporation into 3dprinted titanium implants the incorporated implants will be tested for biocompatibility and osteointegration in criticalsize bone defect models in vivo as we recently demonstrated for the novel materials we will examine several success criteria which will be refined according to input from orthopedic oncology surgeons who routinely perform tumor resections this novel technology is envisioned to significantly advance the current treatments offered following bone resection thereby considerably reducing the risk of further complications and offering a major improvement in the quality of life of patients recovering from bone cancer
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kinase regulation by phase separation
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protein phosphorylation is a process that activates biological and cellular pathways this process is carried out by enzymes called protein kinases that add phosphates to proteins protein kinases are crucial drug targets involved in the onset and progression of human diseases such as cancer and alzheimers disease growing evidence suggests that protein kinases are regulated spatially and temporally by the phase separation and condensation of biomolecules into cellular organelles that are not surrounded by membranes the molecular mechanisms that govern the action of kinases in phaseseparated condensates however are unknown knowledge of these mechanisms is crucial for the development of better drugs that target protein kinases to address this challenge i have designed an interdisciplinary project that goes well beyond the stateoftheart to explore in atomic detail the action of protein kinases intimately involved in alzheimers disease and the abnormal phosphorylation of the protein tau the phasekin project aims to i reveal the specificity and reaction kinetics of protein kinases inside phaseseparated condensates in vitro and in cells ii decipher the dynamic conformational landscape of the protein kinases mark2 and gsk3 by advanced nmr methods that will grant unprecedented detail on their modes of regulation iii disentangle changes in population distributions and rates of interconversion between structurally distinct kinase states inside condensates iv unravel the physicochemical basis of kinase drug partitioning into condensates the highly innovative nature of the project is devised to delve into the heart of protein kinase function and to revolutionize our knowledge about the chemistry of drugkinase interactions findings from the phasekin project will provide critical guidance in the development of more efficacious and specific drugs which target protein kinases
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probabilistic decision framework for resilience assessment of offshore energy infrastructures subjected to seismic submarine landslide hazard proslide
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the offshore energy infrastructure oeisoil interaction has been studied by numerical analyses in the literature however these studies are rarely focused on the performance of oeis during the seismic submarine landslide ssl moreover the pseudostatic approach employed for stability assessment of oei is generally conservative for deep water conditions the dynamic approach needs a wide range of input parameters and spends a lot of time and money on analyses accordingly predictive models are needed to fill the gap between these approaches for a simple prediction of oei deformations during ssl the overall objective of proslide is to develop a reliable and low computational cost solution for simplified resilience assessment of oeis damage due to ssls answering this concern is not trivial but it can guide future analyses and contribute to gaining insights from a calibration effort using numerical models that will be undertaken using a benchmark centrifuge model that can successfully capture key mechanisms and features as well as trends the findings will be based on a database produced via advanced numerical analyses of the oeissl mechanism using the demfem a catalog of nearfault ground motions machine learning technic and probabilisticfragility analyses a twoway transfer of knowledge is guaranteed since i have a solid background in the development of earthquakeinduced sliding models and ground motions databank and also my supervisor at aau has vast experience in the resilience assessment of oeis and datadriven models moreover my supervisors at secondments rmithkust have great experience in the fields of oei numerical simulation and physical modeling accordingly this will ensure the achievement of this timely and innovative project as well as the dissemination and exploitation of the expected results the acquired skills will allow me to embrace an academicnonacademic career path in the eu
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nonthermal radiation from astrophysical jets from theory of plasma turbulence to observations
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relativistic jets from active galactic nuclei agn and gamma ray bursts grbs have fascinated astronomers for decades despite its importance for multimessenger astronomy astroparticle physics and galaxy evolution the physics of relativistic jets is not fully understood according to a widely accepted paradigm relativistic jets extract the rotational energy of the black hole via electromagnetic stresses and transport it out to large distances in the form of poynting flux however we do not understand how the poynting flux is converted into the nonthermal radiation that we observe since relativistic jets have huge reynolds numbers turbulence could naturally dissipate the magnetic energy and accelerate a population of nonthermal particles which emit the observed radiation via synchrotron and inverse compton cooling developing concrete jet emission models based on such scenario has recently become possible due to the advent of largescale fully kinetic simulations of magnetically dominated plasma turbulence a crucial finding of these simulations is that particles have a strong pitch angle anisotropy namely particles move nearly along the direction of the local magnetic field contrary to the textbook and ad hoc assumption that the radiating particles in relativistic jets are isotropic i propose a project aiming to investigate nonthermal radiation from astrophysical jets from theory of plasma turbulence to observations raspo in this project i will develop models for the pitch angle and energy distribution of the radiating particles that rely on fully kinetic simulations rather than ad hoc assumptions and fit these model to the nonthermal spectra of agn and grb jets i will study the apparent contradiction between fitting of nonthermal spectra with existing isotropic models which suggest that the emission region is matter dominated and theoretical expectations which suggest that jets should be instead magnetically dominated objects
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cardiovascular disease energy dysregulation and the role of depression and the social cure
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depression affects over 300 million people worldwide and is the single largest contributor to global disability according to the world health organisation who research has highlighted that individuals with depression have a twotofour fold increased risk of developing cardiovascular disease cvd notably cvds are the most common cause of death globally and are a huge economic burden to society for example in 2015 alone cvds cost the eu over 210 billion who however the mechanisms linking depression with increased risk of cvd are poorly understood posing a challenge to the development of appropriate interventions to reduce this risk cedar aims to elucidate the potential biological mechanisms linking depression with increased risk of cvd by adopting stateoftheart techniques from exercise physiology and clinical psychology specifically this interdisciplinary and timely project will be the first to examine the relationship between depression and energy dysregulation during stress and will consider the role of gender and depression severity cedar will also test an intervention for reducing the risk of cvd in individuals with depression applying knowledge from the social identity approach to health a social cure intervention will be employed to examine if this has an influence on i physiological responses to stress and ii if this influences stress responsivity in individuals with depression the results of this project will not only elucidate the relationship between depression and cvd risk but the advanced research skills learnt during this fellowship can be applied to future projects examining the link between stress responsivity and pathogenic disease risk advancing methods in stress physiology research the experiences garnered by this fellowship including targeted training in communication leadership and project management skills are key in developing the professional maturity and employability of the applicant
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intercellular trading in nucleotide metabolism an emerging target
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anticancer therapy is 70 years old and nucleotides are the oldest target in cancer treatment despite its long history this treatment suffers high rates of resistance and toxicity what are the reasons a cell can gain nucleotides via de novo synthesis dns or from salvage pathways dns inhibition can be bypassed by nucleotides produced by surrounding cells or distant organs causing resistance cancer cells were traditionally studied in isolation with bulk techniques precluding identification of cell typespecific targets causing toxicity to date the cellular sources of nucleotides in healthy and tumor tissues are poorly characterized can the complexity of metabolic crosstalk in tissues be captured by the traditional means i hypothesize that cancer and stromal cells differ in how they utilize nucleic acid building blocks from external and internal sources a single cell resolution is needed to disentangle their interactions and inhibition of both dns and cancerspecific salvage is required for a successful blockade i aim to define the nucleotide sources in heathy tissues and tumors characterize their adaptations to dns blockade to uncover the network of metabolic interactions in tissues and find effective and specific combinations of targets to reach this goal i will use a unique combination of single cell multiomics and tailored mouse models an expertise and tools that i took the lead to set up i will selectively disable dns in the stroma host mouse and in cancer cells syngeneic lung tumors to generate tumors dependent on internally or externally produced nucleotides in an integrative approach using spatial and single cell transcriptomics metabolomics in situ and functional genetic screen i will search for targetable metabolic vulnerabilities of dnsdisabled cancer cells this innovative research opens the path to understanding the organization of tissue metabolic homeostasis for new personalized metabolismbased anticancer medicine
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circularpsp public service platforms for circular innovative and resilient municipalities through pcp
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circularpsp brings together 7 procurers from 7 countries representing 45 million citizens to invest 564 million in rd to tackle the common challenge of accelerating digital transition towards a circular economy ce the buyers group represents highly attractive national markets de fi tr se ie pt si supported by a preferred partner in uk including capitals with global influence berlin helsinki london istanbul the consortium represents european cetransition and pcp leaders in science and practicesuppliers are expected to deliver a new green digital public service and data platform enabling entire municipal operations city and the local economy market to choose open up and consume existing and new data the solution is to support business processes and workflows to plan procure and implement innovative cesolutions across europe more quickly and at larger volume the unmet procurement needs are tools to improve organisational and operational performance data analytics using taxonomies to exploit and exchange ce information and data removal of language barrier to unlock euwide knowledge and learnings to enable the transition suppliers will answer with ict innovation in the crosscutting combination and leveraging of existing and new strategic digital technologies 1 scalable platforms for city and smes users 2 ce data analytics using eu taxonomy open linked data injected by ai and 3 natural language processing nlp to break language barriers across the eu and beyondthe envisaged solution is relevant for all european authorities including cities ministries agencies and housing activity triggered by the solution will increase the volume of circular procurement and widen commercialisation opportunities for green digital companies and result in eu leadership in circular economy with interoperability at the core and innovative tools for data sharing and open standards the solution will provide a use case for the upcoming common industrial and green deal european data
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intracranial neuro telemetry to restore communication
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not being able to communicate while still being conscious is a horrifying prospective for many patients worldwide patients with motor neuron disorders trauma or stroke risk losing complete muscle control leading to lockedin syndrome lis which leaves them completely paralysed and unable to communicate this is an intolerable fearful situation with very low quality of life and extreme burden of care for patients family and care givers intracranial neuro telemetry to restore communication intrecom will provide a breakthrough for these patients by developing a novel fully implantable braincomputer interface bci technology that allows for realtime speech decoding and use in the home environment this bci system will significantly transcend current technology by providing a highresolution and sustainable device combining stateoftheart hardware and software solutions based on artificial intelligence ai to liberate lis patients from their isolation
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mechanisms of human cotranslational quality control and its role in neural tissue
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ribosomeassociated quality control rqc is crucial for degrading truncated nascent proteins produced on aberrant mrnas this is done by elongation of the nascent chain on the large ribosomal subunit in the absence of mrna and the small ribosomal subunit cat tailing and by marking the nascent chain for degradation mutations in rqc components cause neurodegeneration both in animal models and human patients moreover rqc insufficiency and subsequent protein aggregation critically contribute to proteostasis impairment and systemic decline during ageing strikingly we lack mechanistic understanding of this crucial process in humansthis project stems from my postdoctoral research in which i have solved the structure of the yeast rqc complex and discovered a novel rqc factor the eif5a this conserved protein is critical in yeast rqc and was recently implicated in brain development and huntingtons disease moreover i have developed a human cellfree translation extract which enables structural studies of cotranslational processes in the human system in the proposed research we will provide mechanistic understanding of cat tailing and nascent chain degradation in human rqc using cryoem we will define working principles of rqc components and the mechanisms by which their diseasecausing mutations specifically affect neurons in vivo using the c elegans as a model organismour approach utilizes a multidisciplinary approach to provide detailed mechanistic understanding of the critical rqc system in combination with an in vivo study to reveal processes leading to rqcdriven pathological changes in neural tissue since the rqc pathway is conserved in all kingdoms of life and serves a pivotal role in protein homeostasis with critical implications for neurodegenerative disorders and ageing our findings will have important implications for human health and the potential to reveal novel drug targets
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upcycling of ndfeb magnets in the eu for green applications
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the neocycle project aims to demonstrate at trl6 the sustainable upcycling of spent ndfeb magnets comings from hard disks drives hdds reaching high quality end products for 4 case studies pharmaceutical ammonia fertilizers and polymers industries and will include necessary paths to reach the market uptake to reach this aim neocycle involves all the relevant actors in the value chain from public authorities to weee recycler companies technology developers associations ngos smes and commercial companies in the targeted sectors a summary of the main activities in provide below1demonstration of a solidstate chlorination electrochemical and purification processes at trl6 to separate nd fe and b reaching market needed purities2demonstration of upcycling approaches for nd fe and b at trl6 by developing industrial catalysts for the four case studies3validation of the quality and performance of final products by leading commercial companies4including processes and products digitalisation mathematical modelling and optimisation monitoring and digital twins of plants and digital product passports5sustainability assessments lca lcc slca circularity risk and energy efficiency green logistics and tea to demonstrate the technoeconomic and social viability of solutions including a guide to consider the gender dimension in the different project stages6paving the way to the market uptake by a assessments of current legislations and future development b performing a standardisation roadmap c plan and develop communication dissemination and exploitation activities including clustering with other projects and at least 13 stakeholder engagement events d creating new business models for at least 11 key expected results and e development of 13 training courses targeting soft and technical skills to promote inclusion and new jobs in the value chains
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exchange bias in twodimensional van der waals heterostructures
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exchange bias has been vital in magnetic storage devices to pin the magnetisation of the ferromagnetic reference layer in a fixed direction it was extensively studied in thinfilm heterostructures however the origin of exchange bias is not well understood due to the subtle nature of the interfaces recent discovery of twodimensional van der waals magnetic materials opens up new avenues to scout for origin of exchange bias unlike thinfilms atomically sharp interface registry of twodimensional materials is crucial for this purpose the primary objective of this project is to do investigations on exchange bias in twodimensional heterostructures to address the most fundamental at the same time enigmatic question what is the underlying physics that controls exchange bias for this the interface domain structure of the ferromagneticantiferromagnetic bilayer heterostructure will be investigated employing advanced synchrotron based xray photoemission electron microscopy facilities with polarisation control which is one of the major expertise of the host embedded into two work packages i intend to tackle this problem in two different interface spin configurations by judicious choice of antiferromagnetic layer i parallel coupling of spins with the spins in the antiferromagnetic layer pointing out of the plane and ii perpendicular coupling with the atomic spins of the antiferromagnetic layer lie in the twodimensional plane electric field control of magnetism has been central to the sustainable advancement of spintronic devices twodimensional materials are extremely sensitive to external electrical stimuli and demonstration of a field effect device based on twodimensional magnetic materials could be remarkable taking advantage of the semiconductinginsulator nature of the antiferromagnetic twodimensional materials in a separate work package i will also demonstrate the electric field control of exchange bias by applying a gate voltage
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twinning for promoting excellence ability and knowledge to develop novel approaches for targeting inflammatory and degenerative agerelated joint diseases
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twinflag is an advanced research consortium consisting of topclass institutions in the field of extracellular vesicles evs flow cytometry and biobanking the main objective of twinflag is to improve capacities of imc in lithuania to implement the excellence in translational research of arthritis treatment and extracellular vesicle evbased biomarker development innovation and research management for this purpose the consortium gathered leading academic institutions in the field of biomedical sciences from ireland ucd and spain inibic which will seek to raise the research profile of imc the consortium partners will share their knowledge during organized schools short term visits and seminars will implement a small scale research for a personalized therapeutic approach focusing on major research interests of imc degenerative and inflammatory arthritis currently available tools for the diseasemodifying therapy of both rheumatoid and osteo arthritis are not satisfactory which is highly associated with the lack of specific and sensitive disease biomarkers the need for the application specific disease biomarkers has been emphasized as they increase the success rate of drug development programmes and thereby accelerate the availability of new therapeutics partnerships that provide access to tissue banks data cell lines biomarkers patients and funding are essential for the development of novel therapeutics therefore this three partner consortium identified the demand to develop an innovative jointresearch strategy comprising application of novel therapeutics for arthritis associated with the development of precision biomarkers for monitoring the efficacy of this treatment the results of this project will contribute to increased attractiveness of imc retention of research talents and mobilization of national and european resources for strategic investments as well as foster networking and business ideas
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frugal artificial intelligence and application in astrophysics
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beneath the amazing colors of the beautiful images collected by telescope facilities in space and on remote mountaintops lie numbers and lots of them these data contain the scientific information astronomers need in order to reveal the physical properties of the universe and the laws that govern its function recent advances in detector technologies and large focal plane ccd arrays enable astronomers to efficiently monitor a hyperspectralmultiwavelength view of the sky thus opening the last unexplored window the one of time domain in short time scales this ability of daily monitoring big swaths of the sky over extended periods produces astronomical datasets at an astounding rate revealing the transient and often violent face of the universe hence researchers need to develop more powerful computational and statistical methods to tackle the data to get the big picture view out of the underlying science details the titan project will appoint an outstanding researcher as the era chair holder of astroinformatics to incept and lead a research program in computational astrophysics and data science which will couple transform and expand two major research operations at forth computer science and astrophysics while rooting an effective bridge between regional research excellence and international missions our grand vision is to create a true interdisciplinary international and multicultural center of excellence for developing the tools methods and applications of computational science machine learning and statistics for research and education in dataoriented astronomy titan will fully unlock the potential of forth the cretan region and greece through the implementation of a set of measures geared towards capacity building expansion of the research program advanced training opportunities institutional development and structural change and intersectoral and international partnership activities in the field of computational astrophysics
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environmentallyinformed functional characterisation of the secondary red chloroplast proteome
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photosynthesis in the ocean is as significant as that of land plants and is performed by a wide range of cyanobacteria and eukaryotic algae the most abundant of which have originated through the secondary endosymbioses of red algae previously i have shown that these secondary red chloroplasts are evolutionary mosaics supported by nucleusencoded proteins of symbiont host and horizontally acquired origin
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lobbying and corporate political connections in europe
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how does corporate lobbying affect democratic representation and economic activity in europe lobbyists play a key role in the democratic process but tight links between business and politics often raise the question of conflicts of interest and disproportionate corporate influence yet we know little about how corporations influence politics in europe current work focuses on the us due to the availability of highquality data in contrast there is a lack of quantitative research on corporate influence in europe the lobconeu project investigates the impact of lobbying and corporate political connections in europe first the project develops an integrated theoretical framework on corporate political activity applicable to different european contexts second the project uses novel data from the new german lobbying register linked data on the professional background of lobbyists to answer the question who becomes a lobbyist third the project uses data on lobbying meetings between of the european commission to answer how do policymaker characteristics affect lobbying finally the project uses linked danish individual and business register data to study why do individuals transition between the private sector and politics lobconeu uses big data and stateoftheart quantitative methods to establish the causal effect of lobbying on politics and firm performancethe lobconeu project will generate evidence on corporate political activity in europe and make new data available to researchers and the public moreover the project informs policymakers about potential economic inequalities and welfare losses resulting from lobbying activities the results will further contribute to ongoing debates among public officials and civil society groups on the creation and reform of lobbying disclosure mechanisms finally by making lobbying and corporate lobbying more transparent the project also contributes to public trust in the democratic process
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twinning towards excellence for privacy enhancing technologies leveraging homomorphic encryption
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the main objective of encrypton is to increase the innovation capacity of sabancı university sü and enhance the consortiums scientific quality and research excellence within privacy enhancing technologies the objectives will be achieved by building scientific capacity management capacity and technical capacity at sü to enhance scientific competences staff exchanges visits of international experts workshops and summer schools are organised for researchers and earlystage researchers to enhance management and administration at sü idea generation workshops impact creation courses proposal preparation workshops project management workshops staff exchanges and participation in tradeshows and business fairs are organised mainly for the administration unit moreover sü will develop a prototype server in an exploratory research project that will provide solutions for data privacy problems sü has planned dedicated activities such as joint publications in journals and participation in conferencesworkshops for disseminating results regular updates on a project website and social media for communicating outcomes and using results from the exploratory project as a basis to develop new projects and networking with databased industries for exploiting results encryptons activities enhance networking between sü and eu partners through knowledge transfer and exchange of best practice encrypton has a scientific strategy for stepping up and stimulating scientific excellence and innovation capacity at sü and focuses on strengthening the research management and administration skills of sü
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future storage systems for the energy transition polymerbased redoxflow batteries
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the efficient storage of electric energy represents a major challenge for a successful energy transition enabling the utilization of fluctuating renewable resources also as base load redoxflowbatteries rfbs are the only type of battery where intrinsically power and capacity can be varied independently from each other making this type of battery perfectly suited for scalable stationary applications rfbs based on aqueous electrolytes with organic polymer active materials have the potential to be suitable alternatives for commercial metalbased rfbs with low co2 footprint perfectly fitting to the goals of the eu green deal in particular polymerbased rfb systems enable the use of costefficient dialysis membranes together with ph neutral table salt solutions as electrolytes nevertheless systems still reveal restrictions in terms of capacity lifetime and temperaturestabilityfuturebat targets a breakthrough in the development of novel organic active materials for rfbs by combining the search for new active entities with the improvement of current polymeric materials on the molecular level by this providing new functions properties the key question will be how far polymeric electrolytes can be tuned by adjusting the molecular structure advanced polymer structures incl hyper branched structures and colloidal systems with varied morphologies as well as novel hybrid organic systems will provide access to hitherto unknown properties eg new photorechargeable rfbs or rfbs having all charged species within one single tank furthermore new sensor systems soc and soh will be applied which also will form the basis for novel 3dprinted lab cells for highthroughput screeningas the outcome pioneering breakthroughs in the field of polymerbased rfbs will be enabled surely targeting high risk high gain stepchanging research but built up on the knowhow of one of the leading international research teams in this rather new field
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trimerstetramers and molecular bec
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a major challenge in physics is to prepare and control increasingly complex physical systems at ultracold temperatures down to the quantum level precise control allows analyzing the universal features of the system and at the same time enables tackling more complex systems this development has led from atomic control to few and manybody quantum systems similarly atomic control has enabled the preparation and study of diatomic molecules a development the pi of this proposal has significantly contributed toour aim is to drive the next milestone on the path to increasingly complex quantum systems in the ultracold we will make use of collisional processes and photoassociation in chemically stable atommolecule and molecular quantum gases to progress beyond diatomic molecules to weakly bound trimers and tetramers we will feedback the developed understanding of these small polyatomic molecules to controlling atommolecule and moleculemolecule collisions currently a hot topic in itself and possibly enable the realization of the first bec of diatomic groundstate moleculesthe experiments will start from atommolecule quantum gas mixtures of 39k and 23na39k and pure molecular quantum gases of 23na39k as available in the pis laboratory and enable studies of weakly bound nak2 and na2k2 we will detect trimers and tetramers and information about their quantum state by ion spectrometry a method from physical chemistryif successful the proposal will extend significantly beyond the state of the art it will extend the world of ultracold gases to small weakly bound polyatomic molecules provide insight into the building of simple molecular systems and how fewbody systems change with increasing number of atoms it might enable precision control of diatomic molecule collisions the longedfor bec of polar molecules and might unlock the full potential of polar molecules for dipolar quantum manybody physics
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nirich engineered cuzrnnico ldhs bifunctional cathode catalyst for highperformance metalair batteries
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the most critical challenges faced by human beings are shortage of green and sustainable energy one of the most critical aspects of research has focused on the generation of clean and sustainable energy and storing these energies for further use the european unions 8th eap 2050 priority objective is to achieve climate neutrality in the union and aims to accelerate the green transition and restore the environment it can be achieved by emerging new technologies in energy generation and storage systems the battery devices that have aesthetic appeal and multifunctionality inspired the rapid development of sustainable energy sources stateoftheart commercial lithiumion batteries have an energy density of 300 wh kg1 which falls short of the expected energy target ie 400 wh kg1 metalair batteries mabs eg lio2 aqueous battery shows higher theoretical specific energy 3582 wh kg1 and energy density 2234 wh i1 it is about 10 times higher than most batteries in the market today but only twofold improvements have been practically reached to date therefore there is a lot of scope for the development of mabs it has the capability to fulfill the energy demand rising from portable electronic devices electrified transportation and gridscale applications as immersed by the european battery alliance the most challenging issue in the development of mabs is the use of precious metal catalysts and insufficient catalytic activity toward the cathode catalysis therefore we need to develop new cathode catalysts in the field of rechargeable mabs that are environmentally benign safe possess high energy density and long cycle life and consist of lowcost materials in this project we aim to develop a transition metalbased nirich advanced cathode catalyst with engineered morphology and improved catalytic active surface area for cathode catalysis the resulting mabs can store maximum energy while keeping the high power density and long life cycle
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assessing and improving access to health and social care services for children rendered vulnerable by abuse
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serena will accelerate efforts to improve access to health and social care hsc for child victims of maltreatment physical sexual psychological abuse and neglect throughout europe the major ambition of serena is to identify and promote the means of improving the detection of child maltreatment cm of limiting its consequences recurrence severe conditions and reducing the induced burden for victims families and societythis ambition will be supported by assessments of current care pathways hsc services the barriers and inequalities when accessing these services before and after the recognition of cm including childrens physical and mental health conditions as well as the financial burden on a societal level our assessments will rely on a mixedmethod approach combining qualitative analyses in 3 eu countries interviews with adult survivors of cm ascm and hsc professionals and quantitative analyses longitudinal cohort study based on hsc administrative data in 7 countries but also aggregated cps data in 26 countries an interdisciplinary participatory synthesis of the findings with stakeholders and ascm will deliver a coconstructed assessment of the situation and the definition of priority actions finally we will design and promote through the consortiums extensive network operationally and economically viable recommendations with potential for transposability across the eu for policy makers and hsc servicesthe serena recommendations will encourage changes in policies in all eu member states so that hsc daily practice can i be assessed in terms of validity and availability of the services in all areas ii identify necessary evolutions to be encouraged through legislative measures data collection and exchange between hsc services and iii provide an awaited shift in cm management the resulting effects of these changes will include improved detection of cm cases and hsc access improved management and reduced overall costs
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natural language understanding for nonstandard languages and dialects
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dialects are ubiquitous and for many speakers are part of everyday life they carry important social and communicative functions yet dialects and nonstandard languages in general are a blind spot in research on natural language understanding nlu despite recent breakthroughs nlu still fails to take linguistic diversity into account this lack of modeling language variation results in biased language models with high error rates on dialect data this failure excludes millions of speakers today and prevents the development of future technology that can adapt to such usersto account for linguistic diversity a paradigm shift is needed away from datahungry algorithms with passive learning from large data and single ground truth labels which are known to be biased to go past current learning practices the key is to tackle variation at both ends in input data and label bias with dialect i propose such an integrated approach to devise algorithms which aid transfer from rich variability in inputs and interactive learning which integrates human uncertainty in labels this will reduce the need for data and enable better adaptation and generalizationadvances in salient areas of deep learning research now make it possible to tackle this challenge dialects objectives are to devise a new algorithms and insights to address extremely scarce data setups and biased labels b novel representations which integrate auxiliary sources of information such as complement text data with speech and c new datasets with conversational data in its most natural form by integrating dialectal variation into models able to learn from scarce data and biased labels the foundations will be established for fairer and more accurate nlu to break down language and literary barriers i am privileged to carry out this integration as i have contributed to research in top venues on both crosslingual learning and learning from biased labels
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paternalism and psychological interventions for promoting empowerment and educational integration among minority girls
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ethnic minority women such as roma and arabmuslim women are one of the most disempowered groups in europe they face both gender and ethnic discrimination already in schools resulting in weaker academic motivation and achievement which then negatively impacts their professional opportunities societal status and welfare of their community the achievement gap is often explained through structural barriers eg segregation poverty however less academic and policymaking attention is paid on the individual and psychological barriers such as on the impact of educators prejudice the goal of the project is to validate an unexplored aspect of prejudice among educators which is especially likely to be directed at minority girls and diminish their performance namely paternalism which is identified here as educators benevolent yet patronizing attitudes towards students firstly the fellow aims to test how educators paternalism impact discrimination in schools and how it produces minority girls psychological barriers to achievement secondly to develop psychological interventions for educators and for minority girls to reduce paternalism and its impact with the overall aim to improve students academic trajectory meanwhile empower them to challenge their groups situation in society the project is focused on roma minority in hungary and on arabmuslim minority in the netherlands the project is composed of four research programs testing 1 educators paternalistic prejudice and discrimination and 2 minority girls internalized paternalism psychological academic barriers and performance and their group identification paternalismspecific psychological intervention programs 3 for educators and 4 for students are designed and will be tested for shortlongterm impact the fellow employs quantitative correlational experimental research methods and uses selfreport and behavioral measures of discrimination performance and empowerment
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investigating manual dexterity in healthy people and patients after stroke using multilocus transcranial magnetic stimulation
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upper limb dexterity is a unique human ability commonly compromised by stroke i suggest that the upper limb dexterity after stroke may be compromised as a result of dysfunctional inhibition of the nearby muscles in patients with mild motor impairment this results in a lack of independent finger movements in moderatelytoseverely affected patients the pathological synergies pose a major problem affecting both proximal and distal joint movements i will develop methods for evaluating the neural origins of the upper limb dexterity and its recovery after stroke and for improving compromised motor control by transcranial magnetic stimulation tms combined with electroencephalography electromyography and structural magnetic resonance imaging i will perform multimuscle cortical mapping using a novel neuromodulation technology namely multilocus tms mtms which allows stimulation of the nearby cortical targets with millisecondscale delays between the pulses without moving the stimulator this unique feature of mtms will enable us to determine local excitationinhibition ei interactions among the cortical representations of different upper limb muscles i will evaluate whether abnormal control of independent finger movements can be structurally and functionally explained in terms of the local ei balance at the motor cortex then i will utilize this information to develop unprecedented mtms protocols that take into account the individual organization of the motor cortex and the possibility of its selective neuromodulation in summary i aim to demonstrate that 1 the intricate patterns of local ei balance at the motor cortex are involved in the orchestration of muscle synergies 2 the malfunctioning of this complex circuitry after stroke can lead to abnormal musclespecific corticospinal excitability and impaired upper limb motor function and 3 the local ei balance can be manipulated with physiologically tuned multisite mtms protocols
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nanoscale integrated magnetic field sensor
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magnetic sensors are present everywhere in our daily lives we often use them in cars robotics medical applications for power sensing electronic compass etc among them magnetoresistive sensors play an increasing role thanks to their relatively small size good sensitivity and low cost however magnetoresistive sensors saturate above typically a few millitesla which is too low for a number of applications besides reducing the sensor footprint is important in terms of costs in addition smaller sensors have also a reduced power consumption which is very important for wearable applications and sensors used in internet of things therefore it is commercially desirable to be able to develop a low cost nanosize magnetoresistive sensor in which the dynamic range could be extended and easily adjusted in the range 80mt400mt commonly used in linear or angular encoders within an erc project which just ended entitled cmosmagnetoelectronic integrated circuitswith multifunctional capabilities a novel concept of magnetic field sensor sensitive to outofplane field was proposed and patented initial experiments performed within this erc project provided very promising results the purpose of this erc project is to make a full proof of concept of this sensor demonstrating its outstanding performance and subsequently move towards a startup creation or licensing of the technology to an existing sensors manufacturer within nanosense we aim to achieve gains over existing sensors by 10x in terms of footprint reduction 50x in power consumption 10x in signal to noise ratio while increasing the sensing range up to 800mt this will make these sensors suitable for integration in sensors network for iot sensors for wearable applications automotive detection of leakage current in electronic circuits detection of microcracks in metals navigation of surgical tools egendoscopes
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circular solutions for fishing gears
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searcular aims at reducing the amount of marine litter and microplastic from the most relevant european fishery contributors demersal trawlers demersal seiners tropical tuna purse seiners and to introduce circular economy practices within the fishing sector value chain including ports by fostering behavioural change searcular will do this by developingtestingvalidating 4 closetomarket sustainable and circular solutions trl79 three of the solutions are related to the use of more sustainable materials as alternatives to the traditional noncircular plastic used in fishing gears solution1 proposes a dolly rope made of recycled polyamide rpa from discarded fishing nets thus it is focused on circularity and more durable materials solution2 is based on certified marinebiodegradable materials for demersal seine ropes the focus is on less impact gears solution3 represents an ecodesigned biodegradable drifting fish aggregating devices dfads used by tropical tuna purse seine fishery and solution4 proposes an endoflife eol fishing gears solution for ports by promoting a replicable management system that enables the pyrolysis of eol fishing gears for a plastic2plastic application the 4 solutions will be tested under real conditions onboard commercial vessels solutions 13 and for the basque country region solution 4 and they will be validated by stakeholders therefore searcular solutions eliminate waste generated from fishing gears circulate materials and regenerate nature
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autonomous small and flexible vessels
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to reduce the societal and climate impacts of transport autoflex will develop solutions for enabling a modal shift from trucks to inland waterway transport and for electrification of both modes the key is to acknowledge that electrification of transport has an impact on vessel and vehicle operations and must therefore be tightly integrated with the transport operations by both modes integration of cargo and energy distribution the autoflex scope is therefore to 1 develop small autonomous uncrewed zeroemission inland vessels that can operate on underutilised waterways that are resilient towards low water events and are competitive 2 develop transport system components and an architecture that enables transhipment between modes urban distribution and strong competition with road transport 3 develop a combined cargo and energy hub stowcharge for generating and distributing electric energy for the transport system 4 develop new business models for operating the transport system providing services for the transport system and for offering services based on the transport system eg energy and urban logistics 5 validate the ship concepts and transport system through simulation and quantitative analysis scale model testing and demonstration and fullscale demonstration 6 develop a roadmap for exploitation recommendations to policy and industry steps towards realisation and propose ket interface standards autoflex enables zero emission transport waterborne and road innovative port infrastructure climate neutral and climate resilient waterway vessels integration of shipping into logistic chains safe and efficient fully automated and connected shipping and competitive waterborne european industries
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integrated carbon dioxide removal and valorization
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the world needs outstanding technology and innovative scientific breakthroughs to reach the goal of extracting ca ten gigatons of carbon dioxide from the atmosphere each year by 2050 direct air capture dac technology is suitable for offsetting previously overlooked emissions one cannot overestimate the potential impact of a functional co2 dac technology not only can it help solve environmental problems but dac technology can also empower the industry to utilize the captured co2 the industrial conversion of co2 into valueadded products will cause a slow but steady switch from fossil fuels turning co2 from our worst enemy to our best friend within the frames of this project redoxnrg will develop new electrosorbent materials for the direct air electrocapture of co2 to advance dac technology we suggest augmenting electrocapture with a new class of redoxactive and electrically conductive metalorganic materials ecomoms
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geothermal extraction and upgrade with flexible usage for industrial heat applications
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the geoflexheat project aims to revolutionize the european geothermal energy sector by introducing an innovative suite of technologies to enhance the extraction efficiency and application of geothermal heat across diverse industrial sectors this initiative is driven by a consortium that synergizes leading research institutions smes and industry experts to tackle the challenges of scalability integration and social acceptance associated with geothermal systems at the core of project lies the development of a heat pipe heat exchanger coupled with an advanced scaling reactor to improve heat recovery from geothermal brine while simultaneously providing valuable mineral byproducts this is complemented by a novel hightemperature heat pump that delivers costeffective and hightemperature heat crucial for a wide range of industrial processes and beyond the project will also deliver a stateoftheart control strategy and digital twin optimizing system performance and enabling realtime management of geothermal plants through comprehensive simulation and modelling the project will showcase the full potential of geothermal energy to provide stable affordable and sustainable heat supply the ambitious goals include fostering europes global leadership in renewable technologies ensuring reliable energy supply for industries and households and accelerating the integration of carbon capture utilization and storage with geothermal systems to ensure the projects outcomes have a lasting impact geoflexheat will execute robust commercialization strategy including the establishment of a spinoff company extensive environmental and economic assessments and the creation of a social acceptance guide to facilitate policy influence and community engagement embracing a future where geothermal energy is a cornerstone of europes renewable energy mix geoflexheat is poised to become a catalyst for energy sustainability economic growth and environmental stewardship
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monitor multiple sclerosis evolution using body fluids derive cellfree epigenomics
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multiple sclerosis ms affects 28 patients worldwide 700000 in europe alone and is characterized by subsequent phases of different severity which eventually evolve into a chronic phase and untreatable paralysis current main diagnostic approaches are limited to symptom evaluation and imaging underlying a lack of informative and reliable biomarkers monitorms aims to test the use of cellfree chromatin cfchromatin present in the plasma and cerebrospinal fluid csf as a new biomarker to monitor the progression of ms pathology and response to treatment the proposal includes the development of a new technology based on nanocuttagnanoct to improve and simplify the current methodology used to profile cfchromatinrecently it has been demonstrated that cellfree dna in plasma is still wrapped around histones which still preserve the presence of posttranslational modifications termed cfchromatin chromatin immunoprecipitation followed by sequencing chipseq has been recently used to profile cfchromatin from plasma of patients affected by liver and heart damage or cancer showing a pathology and stagespecific signature to decode the information inside cfchromatin a reference dataset is needed the first aim of monitorms is to develop a protocol to profile cfchromatin from plasmacellfree csf with nanoct and compare it to the actual reference chipseq in the second phase the technology will be employed on a larger cohort of samples from a ki biobank including patients under immunosuppressant treatment simultaneously a singlecell multimodal dataset from matched ms patients immune cells and postmortem tissues will be generated to deconvolve the informative content of cfchromatin the final phase of the project will include further integration of the generated cfchromatin data with several ms singlecell transcriptome and spatial data finally machine learning will be used to test cfchromatin as a stagetreatmentspecific biomarker in ms
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magnetoelectric and ultrasonic technology for advanced brain modulation
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the pathological alterations of neurological function eg stroke trauma neurodegeneration epilepsy neuropsychiatric diseases chronic pain are commonly associated with alterations in brain rhythms and activity patterns there is an urgent clinical need for treatments that can precisely control and restore neural activity taking advantage of stateoftheart technological developments in a variety of fields including nanotechnology nano and microelectronics novel materials brain science clinical neurology and computational modelling metabrain magnetoelectric and ultrasonic technology for advanced brain modulation brings together seven expert partners in these fields with the aim of achieving precise spatiotemporal control of brain activity using magnetoelectric nanoarchitectures that can be polarized by noninvasive remote magnetic fields this novel principle of brain activity control will minimize the amplitude of the required magnetic fields be wireless and have enhanced spatial resolution from single neurons to cortical areas we will develop a modeldriven fabrication of the coils and monitor the effects on brain function with arrays of graphene microtransistors that uniquely allow fullband recording integrating all elements in a closed loop as an alternative to remote brain stimulation we will also use novel ultrasonic technologies the metabrain control paradigm will be systematically studied in preclinical systems from individual neurons to the full brain all developments and experiments will be carried out in conjunction with theoretical models that will simulate quantify and predict optimal arrangements and patterns for the desired output translation to humans will be evaluated with our clinical partners and a detailed dissemination and exploitation plan will be developed by two expert company partners one of which has extensive expertise in the fabrication of brain interface devices with a worldwide distribution capability
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charting female property and patrimonial rights in law and practice across western europe 12th16th centuries
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from the mid12th century all over europe laws started to be enacted that hindered women from acquiring and managing wealth triggering a long process that on the threshold of early modernity led to a dramatic reduction in their economic opportunities the importance of the issue is undeniable not only because female agency has been a central theme in gender studies but also because the effects of these developments are still felt today yet the underpinnings of these developments are far from clear the period which is being taken into consideration coincides with a foundational phase of contemporary europe which saw profound economic social and political transformations changes in family structures and complex legal developments so why certain laws began to be enacted at this precise moment how is the cutback in female economic rights connected to the late medieval developments to what extent and how did female economic rights vary from one context to another the aim patrifem is to provide answers to these crucial questions through an innovative and extensive research covering three regions with extremely diverse characteristics in terms of legal traditions and socioeconomic and political frameworks italy france and the germanspeaking area research will involve the collection and management of large data sets it will be carried out in different archives across europe using two main bodies of sources statutes to chart the developments in property and patrimonial rights and private sources eg notarial records to observe how laws were interpreted or even preempted in practice the methodology which can be adopted for different areas across time will be instrumental to future research the data will enable to develop an interactive digital atlas which will represent an unprecedented attempt at charting a chronological geography of female property and patrimonial rights in law and practice across europe over the span of five centuries
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opposites attract crosstalk between vimentin and microtubules mechanical stability vs dynamic adaptability
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the cytoskeleton is mainly composed of actin microtubules and intermediate filaments it is fundamentally important for many cellular processes which is reflected in its morphological and functional diversity in the past indepth analysis of actin and microtubule networks made it possible to reconstitute their diversity in vitro with astonishing precision this enabled a detailed understanding of the mechanisms underlying actin and microtubule network formation which are the basis for many cellular processes in contrast our knowledge of intermediate filaments is still in its infancy and we are far from rebuilding complex intermediate filament networks and their interactions with other cytoskeletal elements in vitro as intermediate filaments are a major determinant of cellular resilience against mechanical stress and their mutations associate with diseases detailed insight into intermediate filament network formation and properties will represent a milestone in cytoskeletal research the proposed project will be a major step in this direction we focus on vimentin the most ubiquitous member of the intermediate filament family we will investigate the role of vimentinmicrotubule crosstalk as well as the relation between network morphology and mechanical stress how do these networks provide cells with mechanical stability while being able to rapidly change their morphology through a combination of biochemical structuring and mechanical methods we will address this question which is relevant in many biological systems from subcellular structures to tissues and organismsin this way crosstalk will pave the way towards a clearer picture of this heavily understudied cytoskeletal filament it aims at integrated mechanistic insight into the organization and mechanical functions of vimentin and its interactions with microtubules which form the basis for understanding its role in many higherorder physiological and pathological processes
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wireless test fixtures to measure the dielectric properties of materials in rf
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rf characterisation of dielectric materials is increasingly an important scientific and commercial activity insofar as even if a very significant effort of the rf community has allowed the development of reliable characterisation solutions it remains that these techniques rely on rf test fixtures that is heavy to implement expensive with a limited field of use type of materials frequencies resolution and therefore not adapted to the everincreasing needs of companies most of which have neither advanced skills in the field nor the equipment to implement these characterisation methods indeed the explosion of the iot and thus of wireless communication solutions has given rise to the need for companies in a wide range of sectors not only specialised in electronics and even less in rf to have a better understanding of the rf performance of the materials they use or wish to use for the fabrication of their devices for cost or supply reasons these companies are forced to use materials that are not necessarily suitable for rf or simply whose rf characteristics are not known typically plastics that under the same name may in fact have very different dielectric characteristics particularly in terms of losses and therefore pose a problem the idea of the project is to demonstrate the technical and economic viability of a new solution for rf characterisation of dielectrics this approach breaks with the techniques currently used insofar as it will make it possible to be able to characterise a larger number of materials plates solids liquids powders etc at a lower cost compared with current solutions we hope that in a few years this solution will become the reference solution for a large number of companies that until now have not access to these test fixtures
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expanding the value of extracellular vesicles as carriers of biomarker and therapy in precision healhcare
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extracellular vesicles evs have been identified as important signaling mediators in a myriad of physiological and pathological processes there is an emerging effort to advance the exploitation of evs in precision healthcare with special emphasis on drug delivery and liquid biopsy however the current technology readiness level in the field and lack of standardized methodology guidelines are limiting the exploitation of evs so a significant leap toward the establishment of novel tools has to be made expandevs main goal is to provide a unique solution for advancing the current diagnostic and therapeutic potential of evs by developing and implementing versatile scalable costeffective and reproducible purification systems based on singledomain antibody affinity technology for highperformance scalable evs capture in two parallel lines of research ithe system will be validated in clinical laboratory settings on breast bc liver hc and lung cancer lc by analyzing differential expression of multi omics proteomic glycomic and transcriptomic evsrelated features with the goal to develop a panel of biomarkers that would contribute in timely diagnostics enable a convenient and noninvasive prognosis assessment and tailored therapy iidevelopment of gmpcompliant protocol for producing edible plant evs as carriers of therapeutic sirna molecules their safety profile and therapeutic potential will be tested on bc hc and lc cell lines and mouse models by establishing a consortium composed of excellent research groups and smes across europe expandev will bring forth the needed paradigm shift in evs research by solving the major bottleneck issue in the field creating a simple robust cheap scalable and reproducible evs purification system will provide muchneeded technology for application of evs in personalized medicine leading the transition of evs use from a promising laboratory concept to a feasible and applicable theranostic agent
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astrophysics center for multimessenger studies in europe
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acme the astrophysics centre for multimessenger studies in europe addresses the ec call to provide wider simplified and more efficient access to the best research infrastructures ri available to researchers in the astronomy and astroparticle physics communities acme is set up to realize an ambitious coordinated europeanwide optimization of the accessibility and cohesion between multiple leading ri offering access to instruments data and expertise focused on the new science of multimessenger astrophysics acme will forge a basis for strengthened longterm collaboration between these ri irrespective of location collaboration and user training will be specifically aimed at levelling up access opportunities across europe and beyondacme objectives are implement the european roadmaps recommendations and act as a pathfinder to broaden improve and align access to the respective ri services and data and assess and evaluate new models for better coordination and provision of atscale services provide harmonized and inclusive transnational and virtual access to worldclass ri develop centres of expertise providing expert support to enable easier access for more researchers improve science data products management to facilitate both focused research goals and serendipitous discoveries implementing fair approaches to broaden access improve interoperable systems for rapid identification of astrophysical candidate events and alert distribution to the network of ri and scientific consortia to optimize followup observations provide training for a new and broader generation of scientists and engineers open the astrophysics and astroparticle physics data sets to other disciplines such as environmental studies or marine biology for the undersea neutrino facilities and increase citizen engagement in scientific research
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wind energy harvesting for ship propulsion assistance and power
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longdistance maritime transport provides 8090 of global trade but strict regulations around nox sox and greenhouse gas ghg emissions are set to cause major technological shifts whilst the pathway to achieve the international maritime organisation imo target of 50 ghg reduction by 2050 is unclear what is clear is the need to drastically reduce the industrys dependence on fossil fuels liquified natural gas lng is reaching mainstream and provides 2030 co2 reduction and other alternative fuels such as ammonia hydrogen or biofuels could decarbonise much further but face significant barriers concerning financials resource potential and acceptability in tandem considerable fuel and ghg savings could be attained by implementing efficiency measures such as slowsteaming improved ship design and utilising renewable resources with wind being a truly maritime feature the onboard harnessing of wind energy will play an important role in the decarbonization of the longdistance maritime transport industry however its uptake has been slow and there are significant challenges to its widespread adoption in the commercial shipping sector whisper will develop a novel modular retrofit solution comprising a windsolar hybrid power system to significantly reduce auxiliary engine emissions and a tilting wing sail system to provide windassisted propulsion significantly reducing main engine fuel consumption and emissions wind power will be harnessed through novel containerised turbines which will be demonstrated on an inservice container ship with efficiency savings of 153 whisper will prove the technical and financial viability of the complete retrofit solution on inservice bulk carrier vessel demonstrating efficiency savings of 298
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hardwareassisted adaptive crosslayer security for computing systems
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todays computing systems are facing an unprecedented security threat posed by recent attacks that use software to exploit hardware vulnerabilities as shown by attacks like spectre meltdown foreshadow and followups affecting a wide range of computing platforms and manufacturers including intel amd and arm these crosslayer attacks reach far beyond exploiting microarchitectural vulnerabilities and allow unprivileged software to exploit a variety of hardware design and implementation flaws as we demonstrated in the worlds largest systemonchip soc security competition that we have been conducting with intel since 2018 this adversarial paradigm shift sidesteps decades of security research that assumed a layered architecture where hardware is flawless and trustworthy existing solutions such as software patching or specific hardware changes are adhoc expensive or only mitigate specific known attacks particularly patching hardware after fabrication is very limited or impossiblethis proposal hydranos envisions hardwareassisted adaptive security a radically different approach to enable flexible security for future computing systems we aim to design prototype and evaluate dedicated configurable hardware inside the soc design to enable postfabrication reconfiguration of key securityrelevant hardware primitives to mitigate new attack vectors moreover we provide an evaluation framework that includes novel hardware fuzzing techniques to significantly improve existing hardwarevulnerability detection methods at design timehydranos is a game changer for trustworthy computing allows to fundamentally and flexibly tackle todays and future crosslayer attacks on securitycritical systems and provides novel research to pave the way towards futureproof security we will showcase our results on opensource hardware widely supported by academia and industry and provide it to the research community allowing open verification by thirdparties
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computational analysis of peripheral literatures
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the ability to attend to literary data in a variety of languages is crucial towards an understanding of literary practices across time and traditions yet few are the languages endowed with adequate computational resources for literary analysis increasing the resources enabling computational literary analysis in lesserstudied traditions is the goal of computational analysis of peripheral literatures compel focusing on galician literature a rich but peripheral tradition at the crossroads of two major romance literatures portuguese and spanish this will be an opportunity to study which features become canonical in a peripheral tradition compared to major traditions influencing it with descriptive and predictive models the project promotes a more inclusive and precise literary history via approaching a tradition little studied using computational means by concentrating on galician a language covered by the european charter for regional or minority languages the project contributes to european linguistic diversity goals beyond galician results are expected to be applicable to comparing core and peripheral literatures in other language contact settings eg the influence of french and spanish literature in catalan or french and german literature in alsatian the project will focus on two genres poetry and narrative and two main galician literature movements in the 19th century and at the turn of the 20th century public domain texts will allow us to release project resources under open licenses we will develop several methods to compare texts across literary traditions among others a supervised learning method perspectival modeling based on versification features and content features carrying out a crosslingual comparison unattempted in earlier studies by comparing a regional tradition with two major european ones compel helps promote a sense of european identity via smarter cultural heritage acess a current eu priority
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privileged mobility and transnational conjugality in islamic countries reconsidering global power relations from a gender perspective in southeast asia and west africa
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while attention on privileged mobility has predominantly centered on retirees tourists lifestyle migrants or obligatory shortterm expatriates scant consideration has been given to the dynamics of medium or longterm settlement linked to transnational conjugality yet privileged migrants often marry citizens of the host country and these migratory and matrimony flows are gendered whereas european women tend to form conjugal relationships with african men european men are predominantly involved with southeast asian women how can we comprehend these cartographies of desire particularly in islamic countries what motivates european men and women to establish permanent residences and families in settings where gender norms significantly differ from their countries of origin how do they adapt to these normative regimes and in what ways do they challenge power relations within the conjugal experience and their host societies furthermore how do they navigate their positions between the two countries to which they belong to tackle these issues the project privileged mobility and transnational conjugality in islamic countries reconsidering global power relations from gender perspective in southeast asia and west africa primco relies on a comparative case study encompassing the mauritanian and malaysian capitals based on anthropological ethnography sociological semistructured biographical interviews focus group and visual methods filmmaking this research critically examines the notion of white privilege shedding a light on the renegotiation of race gender and class relations within intimate and global contexts in addition at a societal level by documenting the experiences of individuals from diverse national racial and religious backgrounds who engage in relationships primco fights against racist prejudice and raises awareness of the existence diversity and richness of transnational families
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centre of excellence of ai for sustainable living and working
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sustainlivwork aims at creating a centre of excellence coe in lithuania for sustainable living and working sustainlivwork specialized in the development and application of ri solutions based on artificial intelligence ai in the manufacturing energy health and transport sectors this coe will act as a lighthouse with far reaching impact strengthening ri in the national and international scope nurturing from a cooperation between key national partners the four leading universities of the country ktu vilnius tech vmu lsmu and advanced international ones tau tuhh that will contribute with their knowledge to boost value creation from advanced technologies the coe is necessary to improve the low development of ai based ri solutions in the 4 mentioned sectors and to increase the sustainability of the country by developing new business models and business process solutions with lower co2 emissions using explainable ai to make those solutions safe trustworthy and transparent it will have an impact on the country and on the whole baltic sea region and beyond by the operation of 4 hubs that will derive into new educational and training programmes an enhanced cooperation with the private sector and public authorities and the creation of a lithuanian ai cluster to foster transition towards sustainability with a particular focus on the s3 priorities areas it will finally improve the lithuanian position in eu innovation scoreboards increase the international collaborations mobilise national european and other international funding programmes by creating service packages ai labs and different collaborations both national and international
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how play shaped the united states from new media to politics worlding america 15032028
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worlding america researches how play has been a key force in the past and present process of creating america as a coherent and hegemonic world from 1503 to the present play is an activity linked to change serious even when frivolous potentially transgressive even when rulebound play intersects with the process of worlding bringing a new world into existence in liminal moments in such unstable phases when new worlds take shape but are not yet consolidated play comes to the fore as a way to probe possibilitiesi seek out such historical moments of disruptive play when a new visual medium was introduced that contributed directly to tangible political change i study four pivotal cases worlding colonial america through engravings 15901776 worlding the nation through newspaper cartoons 18701924 worlding the body politic through television 19722022 worlding colonial mars through twitterx 20062028 tracing specific elements of play in particular imagination invitation participation and improvisation across cases i demonstrate how forms of play have been essential to american worlding in ever evolving mediascapes i hypothesize that play has intensified through the rise of social media to such an extent that current forms of worlding driven by play have overridden traditional rules of politics thus changing the game while playing iti employ sourcebased qualitative methods from cultural history media studies and american studies to synthesize these cases of hegemonic playful worlding into a comparative transhistorical framework i move beyond american grand narratives so as to understand the role of play in their construction and implementation thus contributing an innovative dimension to the composite field of american studies additionally i explore potential for counterhegemonic play
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traumatized subjects mental health violence and the fabric of europe between the wars 191839
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trauma examines the transnational and transmedial circulation of key discourses regarding mental health and violence that emerged in interwar europe 191839 i argue that although the conflict between competing ideologies fascism liberal democracy communism undermined the construction of european identity discourses about mental health and violence played a vital role in fostering the formation of ideas practices and values that would later become a central part of the fabric of europe focusing on britain and italy and combining cultural studies medical legal and transnational history trauma explores the depiction of mentally traumatized world war i wwi servicemen committing violence analyzing sources such as medical and legal texts novels periodicals war memoirs and handbooks for soldiers trauma tracks the negotiation of transnational discourses about veterans mental health and violent behavior across britain and italy due to their antithetical nature nationally politically and medically and the opposite roles played by their veterans after wwi these two contexts offer a unique window into the european experience of war trauma and its effects eg posttraumatic stress disorder domestic violence and allow to trace the cultural shifts and historical processes eg the demythization of the soldier the rejection of the war that informed the later sociocultural construction of europe conducted within three leading universities padua return phase georgetown outgoing phase and hamburg secondment trauma promotes debates on how cultural studies can address europes most pressing concerns as testified by the eu4healthprogramme 202127 and fosters international collaborative research on mental health trauma violence and european commonality through a range of outreach activities involving academic and nonacademic audiences and institutions trauma will have major impacts at cultural social and educational level
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unifying classicality and nonclassicality
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this project aims to bring together the study of classicality and nonclassicality within the fields of mathematical logic and philosophy of logic the project is divided into two parts first we will unify classical and nonclassical foundations of mathematics within a settheoretic framework moreover our approach is distinctive from previous attempts of such unification we believe only an algebraic approach has sufficient generality for such a task secondly we will extend our reconciliation of classicality and nonclassicality to the area of philosophy of logic and philosophy of set theory in particular we plan to unify the study of settheoretic and logical pluralism we believe this will allow us to gain new insights into both fields of study
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seeing like a city
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seeing like a city slac metaphorically assumes the citys perspective to explore visual media and filmmakings potential for knowledge production on cities and civic action within them intended as the entanglement of relations among human and nonhuman populations it addresses existing vision problems within urban studies and planningthe project pursues an in depth critical study and structured integration of audiovisual methodologies in urban studies to see how they can be key sites of urbanism in the making and produce change in the fieldcapitalising on the generative intersections between filmmaking and urban studies it seeks to visualize multiple but often unseen elements of citymaking in so doing it aims to decolonize urban studies and repoliticize planning it will focus on the specific declination of unseen that has to do with the citynature nexus towards a morethanhuman frame for urban studies it will rely on sensory ethnography affective multimodalities in storytelling and participatory and collective filmmaking as applied at the sensory ethnographic labs and the film study center fsc at harvard inspired by efforts to redefine urban studies through depostcolonial notions and approaches it will involve a secondment at the cartography lab at hamburg universitt uuh while there the project will design an audiovisual work that i will develop during the return phase to italys department of architecture and urban studies dastu at polimi which will be the pilot project of a new audiovisual urban lab which will be born at dastu thanks to the msca postdoc grant the projects novelty lies in this critical and actionoriented transdisciplinary aspect mobilizing processes of radical openness sennett 2018 and exchange between research in urban studies and audiovisual production as a potential tool of citymaking intended as that specific city design philosophy aiming at tuning the contemporary to the future laundry 2009
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transparency solutions for transforming the food system
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the titan project will demonstrate the latest transparency related solutions to help drive the formation of a demanddriven european economy predicted on the production and consumption of healthy sustainable and affordable food comprising 28 partners from 14 countries 10 ms and 2 associated countries titan will provide an extensive platform for the development of a wide range of innovations that aid transparency and address key challenges identified in the european green deal egd with a broad mix of cuttingedge technology providers smes and startups linked to leading research centres and agrifood stakeholders titan through dedicated business support together with a 125m open call will provide a fertile breeding ground of ideas and solutions for businesses to thrive within the new strategy of the egd through a cocreation approach 15 innovative solutions including exploiting blockchain ai and iot will be demonstrated in a first wave of titan transparency related innovations these will be supplemented by a further wave of innovations on themes selected by stakeholders in an open call that will be open at the end of year 1 of this fouryear project the new innovations will deliver transparency solutions in the areas of food safety and authenticity traceability health and sustainability and improving information to the consumer the innovations will be supported by cross cutting wps dedicated to transparency ict solutions policy business support management and communication and dissemination the project is led by industry facing notforprofit organisations with extensive outreach capabilities within europe and beyond that will enhance the transferability and upscaling and impact of titan solutions and provide the building blocks of a demanddriven economy that provides healthy sustainable and accessible food for its citizens
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harnessing the microbial potential of fermented foods for healthy and sustainable food systems
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european consumers are expressing a clear demand for healthier and more sustainable food fermented foods ffs have the potential to meet these expectations but there is a need to demonstrate their health impacts scientifically while developing innovative strategies to tackle both sustainability and nutritional health in this frame domino will investigate the health impacts of ffbased diet on a healthy population and a cohort suffering from metabolic syndrome to better focus on health biomarkers we will provide tailormade microbial solutions using an integrated omics strategy and computational biology modelling to address the challenges associated with sustainable food production and healthy nutrition in six food case studies selected as representative of the wide diversity of plantbased ff prototypes we will involve key stakeholders in a multiactor approach these objectives will lead to key results the characterization of the health effect of milk kefir the application of diagnosis tools based on healthy microbiomehuman biomarkers to inform dietary recommendations based on ff for people with metabolic syndrome the development of an open access database and new computational tools for profiling food microbiomes metabolic interaction during food fermentation and their overlap with the healthy gut microbiome the delivery of a research and innovation workflow to facilitate the smart design of functional healthy ff biowaste valorisation sustainable processes on plantbased food case studies using the leverage of food microbiomes biodiversity all supported by a federation of key stakeholders and citizens through several living labs and a tailored dissemination strategy together we will develop and move towards a vision of the future of ffs in europe while enhancing the trust of citizens in the food value chain through their involvement and genuine integration of their perspectives paving the way for citizenfriendly innovation
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attracting and connecting innovation ecosystem actors for international coinvestments in advanced traction of deeptech companies from wielkopolska lithuania and andalusia
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assumptions there are many incubation and acceleration programmes in modest and moderate innovation ecosystems however there is much fewer investors operating there as well the volume of capital available and actors of innovation ecosystems are not well connected the potential investors capital and industry need relationships of trust with locallybased coinvestors of smaller scale that would help them with the local deal flow as well as regulation guidance the startup ecosystems all over the world are oriented toward speed exits which does not favour deeptech startups that need more time for development even the vibrant startup hubs in europe have problems in creation of deeptech deal flowobjectives of attraction1 to connect the ecosystems in wielkopolska lithuania and andalusia to strong innovation networks of germany and france and stimulate crossfertilisation effects through best practice sharing and learning by cooperation syndicate a curated pipeline and portfolio of companies at different funding stages to create joint syndicated thematically focused deal flows that attract international investors boost existing support programmes of business acceleration providers 2 to create investment opportunities for societyrelevant deeptech solutions twin transition and healthtech iot ai for social challengesproject idea attraction and connection of existing acceleration initiatives and investment networks from the participating areas development of durable international relationships through concrete actions ie pilot acceleration programs oriented on society needs solutions stemming from rd joint activities increasing the level of trust among investors and founders from less connected ecosystems create syndicated international deal flows in selected category of technologies boost coinvestments in less connected regions support startups diversity backgrounds founders women migrants founders
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3d silicon detector for imaging of diagnostic and therapeutic nuclear medicine radiotracers with outstanding efficiency and high spatial resolution
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this project aims to design construct and evaluate a novel instrument for molecular imaging of radioactive nuclides in the human body the hypothesis is that by using nextgeneration silicon sensors to measure each photon interaction and applying kinematic constraints the incident photon direction can be calculated thus we can remove stateoftheart mechanical collimators the main objective of this project is to explore the physical limits of efficiency and spatial resolution and evaluate the concept for this new technology in medical imaging applicationsthe new instrument should improve detector efficiency by about a factor of one million reducing examination time from an hour to less than a second the concept aims to overcome compton cameras shortcomings such as complicated geometries with low efficiency that despite several attempts prevented this technique from going beyond an early prototype stage the new sensor concept consists of a massive block of silicon built up from a multitude of sensors with high resolution in space energy and time and including signal shaping and data processing the system will have orders of magnitude more readout pixels than ever before in medical imaging the system design and image reconstruction process are conceptually challenging addressing several scientific problems at the component level such as pixel charge collection and capacitance but also including image reconstruction from fragments of event circles combinatorial problems involved with tracing each event to discern the correct order of interactions and to reject background events over a 1020year period the technology could replace the current installed base leading to significant impacts on adjacent research fields such as drug development and targeted radionuclide therapy
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isocyanate free selfblowing biobased circular foams
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plastics have been key materials to be aligned with the european unions sustainable development goals this promise stems from its lightweight lowdensity nature while maintaining favorable mechanical thermal and insulating properties nevertheless plastic production still lacks sustainability primarily relying on fossil resources indeed less than one percent of the annual plastic production 390 million tons originates from renewable sources this heavy reliance on fossil resources exacerbates global warming as the extraction production and disposal of these materials release greenhouse gases into the atmosphere furthermore in europe less than 20 of postconsumer plastic waste is recycled in the realm of plastics polymer foams merit special attention for their versatility combining the main unique plastic properties while minimizing material usage foams serve two main purposes flexible types for uses like packaging and cushioning and rigid foams for insulation construction and high mechanical strength needs despite their remarkable properties foam production relies on nonrenewable resources and toxic chemicals like isocyanates and phosgene additionally their exceptional performance relates to their highly crosslinked nature which also renders these materials challenging to recycle or often nonrecyclable the central goal of ecofoams is to develop biobased foams that not only match the manufacturing process and performance of commercially available foams but also offer recyclability and reprocessability to do so ecofoams will explore the use of salkylation reaction to produce selfblown polycarbonate pc and polyhydroxurethane phu foams without using toxic isocyanates dr gabriel perli under the guidance of prof haritz sardon polymat university of the basque country spain will endeavour to pioneer the ecofoams that are both more sustainable and exhibit excellent performances
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