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synthetic data generation framework for integrated validation of use cases and ai healthcare applications
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synthia is an ambitious collaboration between public and private institutions to facilitate the responsible use of synthetic data sd in healthcare applications the project will improve the methodological and technical aspects of sd generation sdg by developing new techniques and advancing established ones for different data modalities including genomics and imaging to improve the generation of realistic multimodal and longitudinal data this project will provide the research community with approaches for transparent benchmarking of alternative sdg methods for specific applications identify and establish evaluation metrics and methodologies and contribute to the standardisation of an evaluation assessment framework for sd robust evidence of sd applicability in a set of use cases across a broad spectrum of medical conditions will be crucial to demonstrate the potential of sd to accelerate datadriven solutions of equivalent quality to those derived from real patient data furthermore legal and regulatory implications of sd use will be analysed with the aim of delivering an assurance framework to guide secure sd utilization in healthcarethese significant breakthroughs will be implemented through the open synthia federated platform facilitating responsible sd use by the health research community the platform will facilitate users longterm access to extensively validated reusable synthetic datasets as well as to sdg workflows and sd assessment frameworks the federated infrastructure will rely on extended opensource frameworks for interoperability with other datasharing infrastructures in the context of the european health data space a multidisciplinary collaboration of sdg developers fair data experts clinical researchers developers of therapies and databased tools legal experts socioeconomic analysts regulatory policy advocacy and communication experts will provide a 360 vision on how to advance healthcare applications through sd use
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selfpowered selfreshaping autarkic skin for wireless motes leaf
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we will combine 3d reshaping energy harvesting and energy storage within a single thin foil the thin foil of several micrometer thickness is going to be fabricated by inkjet and capillary printing on a temporal carrier support and consists of an adhesion sacrificial layer own technology relying on lanthanum acrylic acid coordination polymer and a strain inducing bilayer made of hydrogel and a stiffening layer own innovation technology the combination of specifically designed bilayer polymer system polyethylene alt maleic anhydride type hydrogel and polyimide materials is able to reshape into swissroll architectures with few hundreds of micrometer diameter through a selective etching of the sacrificial layer and swelling of the hydrogel in a waterbased solution we will implement high precision capillary printing hpcap to print dedicated structures with high control over length thickness and separation with submicrometer resolution and high reproducibility of a variety of materials which deliver different functionality selfpowering of the autonomous device is ensured through the use of bifunctional materials deposited into interdigitated microelectrode structures function as light converter and storage materials at the same time the thus created photostorage microscale supercapacitor is embedded onto the thin foil and will serve as autonomous power source for the integrated silicon chip the 2d area of the ultrathin foil delivers maximized surface area of the interdigitated finger structure and ensures sufficient light absorption to power the integrated rfic eg an active tagsensory system the optimized weight r 095 will be granted by the ultrathin nature of the foil around 5um while mechanical stability of the final device is ensured through 2dto3d reshaping key feature of our final device is the ability to retain its functionality also after 3d reshaping and its deployment onto the application surface
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personal natural environmentgenegutbrain interactions based ecosystem for prevention of mental illness in children adolescents and young adults puremind
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puremind will deliver the first integrated mental healthcare ecosystem imhe to predictearly identify mental health disorders mhd and create more optimal personalised interventions to prevent mhd and thereby improving wellbeing in children adolescents and young adults 025 years the ecosystem will mitigate key challenges associated with mhds specifically 1detection 1 in 7 undetected and untreated mhd cases 2efficiency of treatment lack of tools and guidelines for personalised multidisciplinary interventions that work 3access to support and care long waiting times for care due to lack of trained personnel 4inequality disparate and inadequate inter and intracountry mental healthcare services and 5modern cultures and lifestyle the increasingly recognised risk factor of digital addiction resulting in sedentary socially isolated lifestyle contributing to mhd these will be addressed by pureminds approach of combining analytical modelling of dynamical systems in the cyberphysical context of a subjects personal natural environmentgenegutbrainmhd interactions process creating a muchneeded personalised intervention synthesis framework that will be exploited by an ai engine to deliver optimised personalised intervention and a unique digital twin educating young people how mhd might develop depending on their environment and lifestyle these 2 components will be combined in an accessible adaptable mobile app mymind to measure at scale and allow a subject to seamlessly access a 4tier service architecture involving family community clinical and emergency services to support predictionearly detection of mhd empowering them to monitor their own mental health at homeeducationalcommunity settings and taking preventive actions against mhd the imhe will be designed using implementation science approach and will be validated in a 12month pilot study in 7 european countries and 2 lmics covering different socioeconomic and cultural scenarios
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prevention mitigation management of infectious diseases on cruise ships and passenger ferries
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with vast experience indepth knowledge and established expertise in infectious disease prevention and control on passenger ships healthy sailing consortium presents a comprehensive approach introducing innovative multilayered risk and evidencebased costeffective tested measures for infectious diseases prevention mitigation and management pmm differentiated for large ferries cruise ships and expedition vessels this approach covers a preparedness and response to known infectious diseases frequently occurring on passenger ships diseases that have never occurred but for which preparedness is essential diseases of unknown aetiology to ensure preparedness for future emerging pathogenspandemics b the entire passengercrew journey travelling from home to ship and returning onboard during shoreside visits c shipboard operations shoreside company operations port destinations and communities d a global perspective of project outputs towards communities and passenger shipping industry epidemiological studies risk assessment modelling for disease spread and aerosoldroplet dispersion and setting disease thresholdsalert levels will develop a scientific evidencebase and support production of evidenceinformed guidelines on covid19 for shipsports passengerscrew vaccination ventilation systems and expedition vessels medical operation needs developmenttesting of shipspecific syndromic surveillance ai systems decision support tools will contribute to early health threat detection onboard riskbased proportionate responses and healthy onboard environments toolkits for blended learning with handson training and technology induced behaviour change will further knowledge awareness and compliance of all stakeholders an integrated epass based on oneid concept and toolkit predicting port response capacities will address port operation and community needs a scientific international panel will promote a harmonized global approach
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spatiotemporal dynamics of secondary metabolism in the ocean microbiome
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microbial secondary metabolism sm is critical to ecological interactions because it is a source of bioactive products such as antibiotics and anticancer drugs marine microbes are prolific sources of these compounds until now the prospection of biosynthetic gene clusters has primarily focused on cataloguing sm diversity by using machine learning ml tools with little regard to their importance for the microbial dynamics microbes benefit from sm by providing a chemical language for interspecific communication and improving environmental interaction the dynamics and evolutionary aspects of this interaction as well as its effects on spatiotemporal microbial dynamics have not been studied due to a lack of suitable datasets to elucidate this the spadynsm project aims to investigate the spatiotemporal dynamics of sm in the ocean microbiome using an innovative genomeresolved work frame to verify diversity mutations selection pressures and effects on environmental variables in a collection of metagenomes from monthly marine samples collected by the host and collaborators over a 7years period dr santos will combine his unique expertise in biochemistry molecular biology bioinformatics and ml with the hosts notorious experience in microbial ecology and evolution to document the fluctuation of sm in marine microbes for the first time on an unprecedented temporal scale spadynsm could lead to a better understanding of seasonal patterns of sm in marine microbes environmental effects and possible impacts on microbial evolution spadynsm continues to advocate for the analysis of polymorphisms at the protein structure level which may lead to the discovery of novel druglike compounds this highly interdisciplinary project with its international collaborative network and innovation will advance the eus research and policy strategies such as biotechnology and microbial community modeling fields and will boost dr santos promising carreer
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satellitebased services to support sustainable land use practices under the european green deal
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the main objective of greeneo is to provide improved satellitebased environmental information to support sustainable nature protection practices across four competing landuse areas cities agricultural areas forests and ecosystems through combined exploitation of new earth observation products digital infrastructure and atmospheric and land surface models using machine learning and data assimilation greeneo will provide environmental information and stakeholder engagement practices to support the implementation of the zero pollution zp and biodiversity aspects of the european green deal egd the project will serve as a proofofconcept to enhance specific services provided by copernicus and eumetsat in support of the egd implementation greeneo aims to support the transition towards more sustainable land use practices in europe and proposes a transformative governance system relying on a data value chain enhanced with active stakeholder engagement and cocreation the value chain proposes the uptake of satellite data integrated in a modelling development chain and followed by value creation modelling applications in cities greeneo will develop three satellitebased approaches of highresolution urbanscale air quality maps to engage relevant stakeholders to support the zp strategies for agriculture greeneo will address impacts on nitrogen emissions deposition and biodiversity it will create satellitebased highresolution emission inventories deposition critical load exceedance maps and identify areas with high recovery potential greeneo will develop a forest fire service that will revolutionize the monitoring of wildfires over europe greeneo will create novel ecosystem monitoring indicators such as city greening indicators ecosystem area and condition indicators greeneo will advance seamless climateweather and environmental services in europe by proactive links to eumetsat wmo the copernicus services eea and eu missions
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deciphering hostgut microbiota spatiofunctional plasticity in inflammation
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over the past two decades gut bacteria have emerged as major regulators of human health the focus in the field thus far has been on bacterial taxonomy with their spatial organization and functionality largely overlooked crohns disease cd vividly portrays this spatiofunctional dimension as it features patches of gut inflammation skip lesions surrounded by uninflamed regionsin the same hostwith a clear demarcation but unknown cause our preliminary data demonstrate hostmicrobe functional feedback loops in which bacterial strains can adapt and modify their immunomodulatory functions in response to the host moreover we find functional alterations in gut bacteria of ibd patients thus we hypothesize that bacterial spatiofunctionality can be largely affected by host physiology and in turn modulate the pathophysiological state creating a functional feedback loopwe propose to study bacterial spatiofunctional plasticity and mechanisms of hostmicrobe interactions in cd and their potential causal effects on inflammation combining microbiology immunology and systems biology approaches we intend to focus on three independent yet complementary aims 1 characterize hostmicrobe spatiofunctional alterations in skip lesions and assess their potential causal effects on inflammation 2 decipher the functional and molecular mechanisms of hostmicrobe feedback loops in healthy and inflamed intestines and 3 develop a toolbox for highresolution functional analyses of gut bacteria directly in their natural environmentsthis study will address for the first time bacterial functional plasticity in response to host inflammation unveiling the phenomena its mechanism of action and potential causal effects on gut inflammation such understanding can shift our perception on microbiotahost interactions may explain contradictions in the field point to novel contributing factors to cd and related disorders and guide future translational studies
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advanced technological solutions coupled with societaloriented understanding and awareness for disrupting trafficking in human beings
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vanguard aims to strengthen the fight against trafficking in human beings thb at the nexus of advanced technological solutions understanding awareness raising and training in order to disrupt the trafficking chain at an early stage and address the culture of impunity in particular vanguard aims to provide an improved intelligence picture of thb with particular focus on thb for purposes of sexual exploitation labour exploitation and forced criminality this will be achieved through developing a modular and trustworthy suite of tools for detecting identifying investigating and preventing onlinefacilitated thb activities and thbrelated activities at border checkpoints based on the analysis of online multimedia content and multimodal streams by leveraging the latest advancements in artificial intelligence ai it will also address the societal dimensions of thb through improved understanding and engagement with relevant actors improved strategies of international cooperation increased awareness and better evidencebased policymaking the capacity of end users including police and border guard authorities will be further enhanced and will enable them to tackle such criminal activities in an effective manner based on advanced tools and solutions and on innovative training curricula vanguard will be validated in field tests and demonstrations in three operational use cases extensive training handson experience joint exercises and training material will boost the uptake of vanguard tools and technologies with a consortium of seven police and border guard authorities including from countries of origin and transit of thb networks and countries neighbouring ukraine one police academy eight researchacademic institutions four industry partners including two smes and two csos vanguard delivers a strong representation of the challenges requirements and tools to meet its objectives
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upcycling mineral and timberbased waste from construction manufacturing process industries through ecodesign advanced logistics quality control and digital solutions
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the transformation of the european process industry needs to embrace circular economy and restorative feedback loops as a key pillar of the design of entire value chains construction as a wasteintensive sector is expected to greatly benefit from the potential impacts of circular economy models to optimize the use of resources reduce exploitation of raw materials and costs associated with its supply in the construction and manufacturing process industries a key challenge to allow the actual uptake of circular economy models and of upcycled repurposed andor recycled materials lies on the need to guarantee that reclaimed materials can offer the same level of quality performance and safety of new secondary products the aim of circuless is to contribute to foster circularity in the construction and manufacturing process industries by minimizing construction and demolition waste cdw as well as manufacturing waste cdm with focus on mineral ie concrete and timberbased material streams which is aligned with the objectives of the processes4planet partnership by developing new processes for circularity of secondary materials from wastesresidues for all industrial processes without compromising quality and performance as well as sustainablebydesign circular products circuless main objective will be addressed by experimenting new circular products and novel processing techniques to improve the quality and performances of secondary materials up to industry expected standards improve value chain environmental friendliness maximize recycled components these actions will benefit from the support and will provide inputs to a tailored digital platform to orient decision making and operational activities finally to foster uptake by the construction sector recommendations for standards updates and relevant training material for both upskilling current construction workforce and create new specialized profiles in the sector will be created
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the social life of ancient dna how can scientists and citizens better interpret the past in light of ancient dna research a dual ethnographic study in germany and vanuatu
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more than ever before humans have access to new specialist knowledge involving genetics eg ancestry genomics social epigenomics crucial questions are at stakes as this newly accessible knowledge grants individuals with an objectifying image of their identity knowing the real or potential biological endowment of oneself others has tremendous social political ethical consequences this project extends my investigation of practices whereby genetics the construction of identities intersect in a field little studied by ssh sts ancient dna adna research at the crossroads of archaeology bioanthropology population genetics adna research entered a golden age in its contribution to untold facts on past societies the way it changes how past populations are perceived while this field is growing rapidly indepth understanding of social political consequences arising from practices knowledge produced are crucially needed we still lack robust ethnographic understanding of how adna researchers incorporate the knowledge they produce into narratives about origins ancestry social relationships meanwhile little is known about what exactly citizens or community stakeholders cs do with genomic histories they receive from adna researchers the main goal is to study how scientists cs interpret the past in light of this new knowledge this project involves two research sites researchers producing adna knowledge in an unprecedented casestudy located in a leading research facility in germany the postcolonial context of vanuatu where knowledge produced from ancient remains raises significant issues for css ancestry narratives studying the production circulation of adna knowledge in interaction between identity from an ethnographic perspective is not only highly original greatly needed but timely this project is utterly innovative invents new collaborations involves fields that spans across social natural sciences
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the interplay of neural networks enabling social interaction
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the quality and number of social interactions are among the best predictors of longterm health so how do good social interactions arise social neuroscience has focused on a number of affective and cognitive functions as potential building blocks of social interaction however utilizing mainly simplistic and passive paradigms we still fail at describing how actual live social interactions emerge and why they so often go awry especially in people with mental disorders here the concept of building blocks may have become an impediment to progress recent evidence suggests that in more complex experimental tasks socioaffective and cognitive processes are not simply stacked up but are dynamically working together just as the underlying neural networks seem to engage in lively interplay interacts main objective is to understand how adaptive social interactions emerge based on elucidating the interactions of networks and processes interact will take a major leap forward with a systematic and mechanistic yet fully sociallyinteractive approach across six work packages interact will move from the comprehensive investigation of behavioral and neural interaction patterns of social affect and cognition in controlled lab settings to completely free social interactions in peoples everyday lives combining a novel experimental approach with dual neuroimaging hyperscanning and multisite neurostimulation neuroeconomics and multiagent ecological ambulatory assessment interact will shift from a modular to a complex systems study of actual social interaction it also provides steps towards specific and targeted interventions in people with social interaction difficulties interact aspires to bridge the gap between basic and applied research developing an interdisciplinary model of social interactions that expands our knowledge and applies it to realworld settings
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sesar3 atm master planning and monitoring
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the master planning and monitoring project so called ample3 is to support the sesar3 joint undertaking s3ju in planning and reporting on deployment activities in deployment covering both industrialisation and implementation and when need be to contribute to the update the european atm mp the project provides content integration ci service to s3ju in support of the development activities and the delivery of a coherent set of sesar solutions aligned at content level with the s3ju mawp direction and ambitions declined from the european atm mpwhile earlier sesar programmes addressed phases a b and c of the sesar vision the sesar 3 ju multi annual work programme mawp presents the strategic research and innovation ri roadmaps of the digital european sky des programme to achieve also phase d of the sesar vision the mawp identified several transversal activities ta to make the des programme not just a list of disconnected projects but a coherent programme supporting delivery of sesar solutions
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mobilise a novel and green mobile one health laboratory for reemerging infectious disease outbreaks
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mobile laboratories are becoming increasingly important for quick response to epidemic outbreaks in remote areas due to climate change and rising temperatures emerging arboviruses crimeancongo haemorrhagic fever virus west nile virus rift valley fever dengue fever are finding their way into europe through arthropod vectors mosquitoes ticks and are becoming a major public health concern optimally monitoring zoonotic outbreaks requires a one health approach in which not only human but also animal and environmental samples are analysed as close as possible to the vectors habitat also returning travellers might carry haemorrhagic ebolamarburg virus or respiratory pathogens such as sarscov2 a survey of existing european mobile laboratory capacity revealed several shortcomings of 193 labs 66 were civilian 88 were exclusively for human diagnostics with 11 having an accredited quality management system and only 3 had the highest biosafety level bsl4 needed for haemorrhagic arbovirus handlingmobilise aims to close this diagnostic gap by developing a novel qualityassured mobile one health laboratory solution to provide bsl4 capacity to many european countries it will receive humananimalenvironmental samples for molecular diagnostics serology microbiology and host a whole genome sequencing platform for pathogen discovery and epidemiological analysis we will further develop novel rapid diagnostic tests for bsl34 pathogens and produce results in machinereadable form a novel aibased emergency operating centre and decision support system software will assist endusers in coordinating mobilise fleets across europe and manage outbreaks in realtime hosted on an electrichybrid truck platform and using solar and windenergy it will also reduce co2 emissions in compliance with the european green deal the lab will be fieldtested to trl7 by national agencies and firstresponders in austria romania greece and africa
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prefiguring democratic futures cultural and theoretical responses to the crisis of political imagination
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democracy is in a crisis of global scale this crisis has variously been attributed to a loss of belief in political representation the rising of technocratic postdemocracy or an authoritarian and populist turn however a narrow focus on the political system is inadequate predef starts from the assumption that the crisis of democracy is also a crisis of political imagination as the infamous tinaprinciple there is no alternative illustrates it has become increasingly difficult to imagine genuine democratic alternatives to the status quo predef sets out to explore potentials for deepening and pluralizing democracy beyond the sphere of politics narrowly defined as the body of existing political institutions the project will turn to the fields of culture art and intellectual history for these fields hold hitherto untapped potentials for extending our democratic imaginary and disclosing political alternatives located at the intersection between cultural research and democratic theory predef meets this challenge empirically and theoretically empirically artistic and cultural counterpractices are investigated that champion democratization in the timebased arts through theatrical occupations international relations through countersummits and law through mock tribunals theoretically the project seeks to widen our democratic imaginary by searching the history of ideas for forgotten institutions that hold untapped democratic potentials and by elaborating a democratic theory of counterinstitutions the main objectives are iregaining a sense of possibility in a time of vanishing democratic alternativesiiexploring the democratizing potential of cultural and artistic practices and institutionsiiilearning from alternative configurations of the past and beyond the western context specifically regarding institutional designsivconnecting theoretical and empirical research with the aim of genuine crossfertilization
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for tunable thermochemical energy storage
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to accelerate the energy transition there is an urgent need for energy storage both for electricity and heat due to the intermittency of renewable resources as a large part of our energy consumption is in form of thermal energy 78 in the built environment and as there is a large amount of unused low temperature waste heat 8900 pj in europe thermal energy storage offers route towards bridging availability and demand long term lossfree compact heat storage is the missing link and thermochemical energy storage tces has the potential to play this role unfortunately present tces concepts lack flexibility as a precise fit between the phase diagram of tcesmaterials the system design and the temperature demand of an application is needed therefore most of the rd for applying tces is very specific for a particular application and switching to another application requires that much of the rd process has to be redone 4tunates will deliver a groundbreaking flexible tces technology that can be easily adapted to different applications variable in and output temperatures and thereby reduce the development costs by 90 as the rd the process does not have be redone repeatedly 4tunates develops a tcesprototype that can be used for domestic use cases which addresses three challenges 1 radically new tces materials with tunable phase diagrams by using a second gas or dopants 2 heat exchanging components with a high degree of manufacturing flexibility and 3 revolutionary systems with electricity adapted thermodynamic cycles cnr and dlr will integrate the key findings in their hightrl project portfolio and cellcius cel will integrate the successful materials and designs in their technology this will unlock the potential thermal energy storage for this purpose a strong consortium has been built which brings together computational material scientists vub physicalchemists tue ciiae mechanical engineers cnr dlr and heat battery developer cel
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discovering how t6ss effectors are deployed in the recipient cytoplasm
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interbacterial competition is a key driver of the emergence of new bacterial strains a widely used strategy during interbacterial competition is delivering toxins into competitors cytoplasm where they target conserved components the type vi secretion system t6ss a machine that delivers toxic effectors into neighboring cells is a major player in interbacterial competitions it fires an effectorloaded tube that penetrates the recipient cell envelope although many t6ss effectors target the competitors cytoplasm it is not known whether they are directly deployed there or rather deployed in the periplasm and then transported into the cytoplasm we have recently identified several domains within modular t6ss effectors that are fused specifically to cytoplasmtargeting toxic domains the new domains are required for competitor intoxication during competition but not for t6ssmediated secretion of the effectors therefore we hypothesize that t6ss effectors are first deployed in the periplasm where specialized domains such as these relocalize cytoplasmtargeting effectors into the recipients cytoplasm in imcross we will leverage our unique expertise in identifying and characterizing novel domains within effectors to go beyond the stateoftheart and determine how cytoplasmtargeting t6ss effectors reach their target we will 1 reveal the initial site of t6ss effector deployment 2 identify effector domains responsible for transport across the recipient inner membrane and determine whether they employ receptors in the process and 3 establish a pipeline to discover relocalization domains and cytoplasmtargeting toxic domains in t6ss effectors the discovery of specialized t6ss effector relocalization domains will revolutionize our understanding of effector modularity and trafficking during competition furthermore such domains are key in developing tools to identify novel toxic domains and engineer synthetic toxins as alternative antibiotics
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leveraging anaerobic digestion through environmental stresses
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effective organic waste management and renewable energy supply are essential in our present society such as meeting targets of the european green deal and the renewable energy directive anaerobic digestion can tackle both challenges simultaneously and has been commonly applied for renewable energy recovery in the form of biogas from organic waste the complex and sensitive microbial interactions to environmental stressors can cause the failure of anaerobic digestion imposing challenges for innovation in lead we introduce the microbial niche nexus concept tuning microbial communities and their metabolic pathways to achieve multidimensional microbial networks to achieve more resistantresilient anaerobic digestion systems thus improving resource recovery from waste sources under stressed conditions hence lead aims to train the next generation environmental biotechnologists in order to address key knowledge gaps and develop models and technologies in anaerobic digestion responding to stressed environmental conditions which will revolutionize resource recovery from waste towards circular bioeconomy and sustainable development the 14 tailored projects are tailored based on the designbuildtestlearn cycle to train the doctoral candidates with systems knowledge to deal with challenges for transiting waste removal towards resource recovery through anaerobic digestion to train the 14 doctoral candidates via an international intersectoral and interdisciplinary program lead brings together experts from several disciplines forming a consortium of eight beneficiaries and five associated partners including three industries through both local and networkwide activities and events lead will educate nextgeneration talents with competitive transversal skills and capacities both to the academic and nonacademic sectors further profoundly influencing the future bioeconomy and society
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impact of foreshock transients on nearearth space
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this project addresses major open questions in plasma physics the dynamics of collisionless shocks their impact on the downstream medium and particle acceleration collisionless shocks are powerful particle accelerators ubiquitous in astrophysical plasmas recent works suggest that the dynamics of the shock precursor or foreshock contributes greatly to shock acceleration here we use nearearth space as a natural laboratory to quantify the impact of transient kinetic structures forming in the foreshock these foreshock transients are particularly intriguing because in addition to contributing to acceleration at the shock itself they impact geospace as a whole in driving swift intense wave storms in earths magnetosphere in this proposal i present recent data revealing that these waves accelerate energetic electrons in earths radiation belts connecting for the first time the dynamics of two major acceleration sites at earth this issue has never been explored because of considerable challenges multipoint in situ observations and global kinetic simulations are needed to unravel the complex processes at work the wavestorms project makes full use of recent advances on both of these fronts to resolve the impact of foreshock transients on nearearth space in a holistic manner using a flagship kinetic model of the global magnetosphere and highfidelity space and groundbased measurements we will 1 fully characterise their interaction with the shock and their contribution to shock acceleration 2 quantify the radiation belt response acceleration and losses 3 connect our findings to the solar wind context to finally 4 quantify their global impact on nearearth space my expertise in foreshock physics and in combining multimission data and cuttingedge simulations puts me in a unique position to lead this project our results will constitute a breakthrough in our understanding of nearearth space dynamics and particle acceleration in general
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manufacturing process for biobased fibrereinforced composite parts for structural applications
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currently the use of biocomposites is limited to less critical applications that do not have significant requirements in terms of mechanical performance however the use of synthetic composites made from carbon or glass fibre has several difficulties in terms recycling and in terms of dependence on third countries about 98 of these synthetic composites still end up in landfills and about 80 of the raw materials are currently manufactured outside of europe to improve this situation the project addresses the challenges of using biocomposites for structural parts and aims to increase the range of applications in which biocomposites can be used this will be achieved by developing an accurate draping process to control fibre orientation by creating material models that capture the natural variability of the material and by integrating nanostructured biobased sensors for load monitoring through the increased accuracy and additional control loops in the manufacturing process the consortium expects to achieve predictable properties and constant qualitywithin the project use cases from wind energy and boatbuilding will be investigated aiming at the manufacturing of a full size rotor blade and a ship hull to demonstrate the technical feasibility and achieving trl7 for the manufacturing technologies in addition to the end users the consortium consists of partners from automation machine building measurement technology material manufacturing and simulation software to cover all aspects of the developments based on the predicted growth of the biocomposites market which is expected to increase by a factor of 25 by 2030 the consortium expects a market potential of about 100m by 2030
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iraqi cinema beyond the screen
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in the beginning of the 20th century iraqi cities and urban environments changed and new public spheres and forms of workand leisure emerged new neighborhoods and institutions cafs and theaters changed the structure of urban life in theprocess modern leisure and entertainment began moving from the private realm into the public and increasingly came to beorganized on a commercial scale one index of these changes was cinema which arrived in iraq in the early 20th centuryand quickly became a highly popular form of entertainment a modern and global rather than a specifically iraqidevelopment the emergence of cinema in iraq can be seen as a local inflexion of a global phenomenon situated at thecrossroads of egyptian indian european and american film production cinema in iraqi sheds light on the transnationalqualities of early cinema in iraq itself but also in the many areas across the globe where national cinema only emergedbelatedly yet the development of the specific culture of cinema so significant in the history of iraq as well as in the field ofcinema studies and nonwestern cinema has received scarce attention my project undertakes this fresh subjectinterrogating the transnational circulation of cultural products and material objects including films and technology andexploring how they came together at a particular historical moment with capital performers and people with technical skillsto establish cinema as a form of leisure in iraq studying the emergence of cinema in iraq through an approach that attendsto cinemas material and transnational histories and contexts can enhance our understanding not just of iraq and its manyentangled networks connections and histories but also of early cinema outside of the global centers of gravity finally tecishows how the intersection of capital public space and popular entertainment lays open both the possibilities tensions andconflicts that developed in 20th century iraq
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revealing enhancerderived rna erna transcriptome erna processing and biogenesis during neuronal stimuliactivated transcription
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enhancers are short distal cisregulatory dna regions that drive expression of a gene however enhancers do not function exclusively as dna entities activated enhancers are transcribed by rna polymerase ii rnapii which produces enhancerderived rnas ernas production of erna creates additional transregulatory mechanisms facilitated by dnarna rnarna or proteinrna interactions due to ernas fast degradation rates and lack of robust and standardized sequencing methods reports about the molecular nature of erna molecules and their processing are conflicting making mechanisms of gene regulation by erna controversial even less is known about co and posttranscriptional processing of erna this project aims to overcome the controversy and fill the knowledge gap by studying a welldefined experimental system cultured rat cortical neurons and activation of immediateearly gene ieg response perturbing the core erna endonuclease and combining this with ernatailored sequencing computational and biochemical methods the developed integrative approach will reveal molecular features of erna molecules and their precursors genomewide opening the opportunity to study erna biogenesis to further understand molecular mechanisms behind the ernamediated gene regulation
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adolescent autocracies progovernment student groups in resurgent authoritarian regimes
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democracy in retreat was the 2019 title of the freedomhouse index which ascertained 13 consecutive years of a global decline in political rights and civil liberties from 2005 to 2018 the report foregrounds the alarming erosion of longstanding democracies and those part of democracys third wave which began in the 1970s in southern europe followed by countries in latin america and east asia and culminated in the dramatic regime breakdowns initiated by democratic reforms in centraleastern europe soviet union south asia and subsaharan africa a period that has inspired scholars to deliberate the idea of democracy representing the ultimate end of a countrys political development or even the end of history itself this period of democratization was initially lauded as a linear set sequence which would eventually encompass the globe from the early 21st century on however a new generation of scholars has been describing a reverse wave of regime changes diamond 2015
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wild grapevines endophytic microbiome ecology epigenetics and application in the biological control of wood pathogens a synthetic microbiome approach
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in recent years a general decline has been documented in several agriculturally relevant woody plants and numerousreports point towards a possible role of the plantassociated microbiome this especially applies to grapevines vitis viniferal and to the recent outbreak of grapevine trunk diseases gtd this cluster of fungal diseases is considered the greatestchallenge in modern viticulture due to the complexity of the different pathosystems and the lack of reliable control strategiesduring the last 100 years vineyards have been routinely treated with fungicides insecticides herbicides and fertilizersrecent research have demonstrated that such treatments and other anthropic intervention eg domestication graftingtraining affect the plantassociated microbiome these humandriven alterations exacerbated by grapevines clonalpropagation process are believed to have led to an imbalance in grapevines endophytic microbiome which may be a keyexplanation for the recent success of gtdassociated pathogens the best candidates to investigate the composition of abalanced wood microbiome unaffected by anthropic activities are wild populations of v vinifera subsp sylvestris vvsin this multidisciplinary project i will join the fields of plant pathology epigenetics and microbial ecology to 1 unravel the endophyticmicrobiome diversity of wild populations of vvs using dna metabarcoding and in vitro isolation techniques 2 reintroduceendophytes isolated from vvs in cultivated grapevines by means of a synthetic microbiome transfer 3 assess the efficacyof the synthetic microbiome in antagonizing gtdassociated pathogens a nextgeneration approach to biological controlthe outcomes of this project will not only contribute to advance our understanding of grapevine endophytes ecology buthave also the potential to provide a concrete solution to viticulture for the benefit numerous european and noneuropeancountries
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the mathematics of interacting fermions
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the quantum manybody problem presents us with a baffling variety of phenomena whose mathematical understanding is just leaving infancy one of the most prominent examples is the behavior of electrons in condensed matter surprisingly despite the presence of strong interactions between particles in the microscopic schroedinger equation on a macroscopic level one observes almost noninteracting particles moreover some properties even turn out to be universal ie do not depend on the details of the microscopic equation at all fermi liquid theory has been phenomenologically developed as an emergent theory to describe these correlation effects in systems of interacting fermionic particles the first goal of this project is a rigorous derivation of fermi liquid theory from the schroedinger equation my approach will be based on the analysis of highdensity scaling limits while the analysis of scaling limits has been tremendously successful in the last years for bosonic systems in fermionic systems it has been restricted to the derivation of meanfield theories recently i have developed an approximate bosonization for threedimensional systems which can be rigorously applied in highdensity scaling limits this is one of the few tools that permit an analysis beyond meanfield theory enabling us now to describe correlations without relying on perturbation theory the second goal is to show that onedimensional systems can be analyzed similarly but display a very different behavior called luttinger liquid demonstrating that the approach allows to distinguish fermi from nonfermi liquids thus i will not only provide a unified justification of the noninteracting electron approximation in two and more dimensions but also pave a new way to and partially resolve the classification problem of the fermionic phase diagram
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the neural basis of dynamic territorial aggression and fear
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the urge to defend ones territory is an evolutionarily conserved instinct aimed at securing optimal access to food mates and shelter conflict arises when territories become unstable due to seasonal changes in resource availability or when population density increases under such conditions individuals must carefully balance social aggression and avoidance to maximize their control of territorial resources while avoiding subordination at the hands of their neighbors what is the neural basis of such dynamic territorial behaviors we have found that an evolutionarily conserved medial hypothalamic brain structure serves as a switch between social aggression and avoidance in this proposal we ask where and how is territory encoded in the brain and how could it control this hypothalamic switch a clue emerges from recent work in which we discovered that neural activity in this structure encodes a map of social space much like the mammalian hippocampus encodes a map of navigational space however unlike hippocampal place cells that arise spontaneously as animals explore hypothalamic territory cells require social experience to form we will develop a seminatural laboratory testing environment where we can monitor the dynamic acquisition of territories in mice over time and apply in vivo neural recording activity perturbation and computational modelling to extract precise synaptic integration and plasticity mechanisms that underlie territorybased decisionmaking in the mammalian brain uncovering the neural basis of territorial behaviors is an essential step toward a biological understanding of human aggression and fear and could provide insight into interventions for maladaptive responses to threats to personal space resources and beliefs
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linking community archaeology and wellbeing in the mediterranean
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the project linking community archaeology and wellbeing in the mediterranean loggia aims to understand to what extent archaeology can contribute to community wellbeing loggia will be led by the fellow dr francesco ripanti under the supervision of dr giorgos papantoniou in the department of classics trinity college dublin tcd and encompasses three fields of study archaeology wellbeing and disability studies archaeology may positively impact individual and community wellbeing and especially benefit vulnerable groups since the horizon europe strategic plan includes the employment of strategies of inclusion and empowerment to ensure equal and wide access to cultural heritage assets loggia will adopt a unique approach to address how archaeology can promote community wellbeing in the mediterranean context by focusing on the inclusion of persons with disabilities through case study research as first and second research objectives loggia will outline a novel theoretical and evaluation framework linking community archaeology and wellbeing and assess the impact of archaeology programs on community wellbeing in two case studies of people and things in vignale italy and xeros river valley cyprusthe fellow has a background in archaeology and thanks to the support of the three interdisciplinary tcd centres the medical and health humanities initiative the centre for mediterranean and near eastern studies the trinity long room hub arts humanities research institute and the secondment at manchester metropolitan university will acquire the necessary knowledge in the areas of wellbeing and disability studies an integral part of the research is the nonacademic placement at silversky3d as third objective through the popular videogame minecraft loggia will assess the extent to which the interaction with a digital environment based on the case studies can contribute to the inclusion of persons with disabilities and their wellbeing
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toopi regen unleash the power of urine to finally scale a real closed loop and regenerative farming system
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how can we revolutionize our food system while preserving a vital resource18 million tons of mineral fertilizers are used every year in the eu this massive use threatens our food security health and environment but remains essential for feeding humankind farmers have no viable alternatives at the same time human urine rich in essential nutrients n p k is not only considered as a waste but keep threatening our water sources when flushed in drinking water 6000b l per year in the euat toopi organics we aim to implement a sustainable and profitable agricultural model based on upcycling human urine our unique and patented fermentation process produces microbial biostimulants using urine as a growth medium for microorganisms of agricultural interest as alternative to crop fertilization our urinebased products are approved across europe safe easytouse effective proven in many field trials and economically viable they are fully adapted to scale regenerative agriculture by enhancing nutrients use efficiency increasing soil microbiome biodiversity and avoiding the huge fertilisers greenhouse gas emissions our closedloop solution is implemented at a local scale and is highly replicable urine collection in urban areas and urine transformation in fermentation facilities are localized close to farmers needswith the eic support we will deploy our model in europe and promote a significant paradigm shift in the fertilisation market the global biostimulants market is worth 34b cagr of 11 it remains a niche market with products dedicated mainly to value added crops and not really affordable for field crop growers our ambition is to become a leader of the biostimulant market category dedicated to substitute a significant proportion of mineral fertilisers global market worth 230b by 2030 while increasing farmers profit margintogether we will make a true closedloop regenerative farming system a reality for europe
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skypuzzler solving the puzzle in the sky
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skypuzzler is a novel digital air traffic control atc software empowering the global commercial drone market the drone industry faces significant obstacles related to the lack of efficient atc solutions our autonomous tactical deconfliction service is the missing piece to solve the problem of drone safety by using a sophisticated mathematical algorithm skypuzzler integrates seamlessly into unmanned traffic management utm systems as a whitelabel product enabling drones to avoid collisions it also promotes environmental sustainability indirectly reducing carbon footprint by 90 projected revenue with eic support demonstrates significant growth from 184380 in 2024 and reaching 67243000 in 2028 by then we will have reached 8 market share worldwide our digital atc is crucial to the growth of the drone market to increase the number of drones in circulation by 97 lets solve the puzzle in the sky
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integrated digital solution for sustainable and reliable management of international renewable energy systems
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the increase in energy demand in industry buildings services and transportation together with the associated greenhouse gas emissions bring great challenges to the energy sector to face them this sector must aggressively look for more efficient ways of operations so as to support this growing consumption avoid supply problems and at the same time reduce operating costs the answer to these challenges lies in digitalization which is one of the essential pillars for the transformation of this sector in europe and worldwide interest goes beyond the state of the art with the objective of developing a hierarchical distributed model predictivecontrol for realtime monitoring and energy management of renewable energy systems with improved features such as sustainability stability reliability and replicability this objective will be addressed using innovative tools that will bring intelligence to the system allowing a more preventive than reactive performance which is fundamental to overcoming the challenges already presented such innovations are essential to increase the systems efficiency by improving the control of the energy flows interest will bring to practice the concepts of predictive maintenance and joint energy and health management by using data intelligence for a better understanding of demand predicting and anticipating undesirable faults in a selfhealing operation the ending status of interest concept can be expressed by trl5 aiming to boost the european outstanding position in global applied science this way interest solution presents a great potential of being a leading exporting technology focusing on the emergent markets worldwide and ensuring the political priorities of sustainablestrongly aligned with the eu policy framework for climate and energy the outcomes are oriented towards the development of comprehensive innovative and evidencebased frameworks to move europe into a technological leadership position in this field
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the photoreactivity of artistic pigments from the preservation of historical paintings to new opportunities as singlet oxygen generators
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singlet oxygen so is one of the reactive oxygen species known for being a strong oxidant there are materials called so generators that produce so under light exposure and in presence of oxygen so generators can be found even among the pigments used in historical paintings so has a huge impact in the preservation of these historical paintings since it reacts with the binding media and other artistic pigments causing degradation processes that compromises their integritythe main goal of the photoelectroart project is to understand i the photoreactivity of artistic pigments that generate so ii the impact of the environment and microenvironment in the amount of so emitted by these substances and iii how this can be applied to improve the preservation of historical paintings containing so generator pigments to achieve this photoelectroart will exploit a highly interdisciplinary methodological process based on photoelectrochemistry and infrared spectroscopy including ir nanospectroscopyresults will have a major impact in the understanding of the role of the so emitted by the pigments in the alterations of the historical paintings where these are found providing a detailed knowledge of the degradation reactions throughout the paintings history and helping to find suitable mitigation actions to preserve the cultural heritage additionally the results will provide new information on the conditions that boost the generation of so from those pigments this new knowledge will contribute to the development of innovative applications in fields where a high production of so is needed such as treatment of wastewaters and medical therapies
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safety analysis of smr with passive mitigation strategies severe accident
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small modular reactors smr are one of the key options for the nearterm deployment of new nuclear reactors currently in europe there is a growing interest towards the deployment of smrs and several activities are underway in many countries preparing for possible licensing needs in particular integral pressurized water reactor ipwr are ready to be licensed as new builds because they start from the wellproven and established large light water reactor lwr technology incorporate their operational plant experiencefeedback and include moderate evolutionary design modifications to increase the inherent safety of the plant however despite the reinforcement of the first three levels of the defenceindepth did eg with the adoption of passive safety systems a sound demonstration of ipwr ability to address severe accidents sa should be carried out did levels 45 the main objectives of the project will be to transfer and adapt such knowledge and knowhow to ipwr in view of the european sa and emergency planning zone epz analyses the main elements considered are i the identification of plausible sa scenarios for ipwrs with the related conditions in the vessel and in the containment ii the study of the applicability of the existing experimental databases to ipwr and identify new experimental needs iii the assessment of the capability of internationally recognized european and noneuropean computational tools largely used in europe to describe the behaviour of the most promising ipwr designs during sa scenarios and iv the prediction of the resulting radiological impact on and offsite taking into account special sa mitigationmanagement strategies the expected outcomes of the project will help speeding up the licensing of ipwrs in europe as well as the siting processes of these reactors in light of their possible use near densely populated areas
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doctorate career development and mobility studentships in medical device research and advancements enhancing the cram industryacademia training initiative
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a major limitation for the introduction of novel medical devices to the market is the gap between research outputs and industry interactions innovations arising from academic institutions are rarely well aligned with commercial requirements eg regulatory pricing patient needs this impedes the efficient development of medical devices which increases the time for innovations to reach patients the medical device doctoral programme meddevdoc will address this gap by providing worldclass research and training to 25 doctoral students these students will be highly employable crossborder and sector capable of driving innovation in the european medtech ecosystemmeddevdoc is aligned with the eu principles for innovative doctoral training as well as the eu charter and code and the salzburg recommendations novel aspects of meddevdoc include a personal career development plan which gives students a strong sense of ownership of their own career a focus on sustainable laboratory practice by exploiting nuigs position as the first in europe to be awarded a green lab certification and extensive training in public engagement through the internationally recognised education and public engagement programme which is supported by experts such as teachers filmmakers and artists the university of galway nuig is uniquely positioned to deliver meddevdoc due to its position as headquarters of the cram network cram is the national science foundation ireland research centre for medical devices created by the irish government to close the gap between research and industry in the medical device field nuig will work together with the 8 other highquality academic centres within the cram network as well as 14 industry partners to implement meddevdoc upon completion of the 60month programme the next generation of entrepreneurialmultidisciplinary and creative innovators in the field of medical devices will be ready
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anticipating the impact of armed conflict on human development
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armed conflict is human development in reverse the full scale of conflicts impacts remains unknown however and fragmentation of research into multiple academic fields limits our understanding this multidisciplinary project brings together scholars from economics epidemiology political science and conflict research to study the impacts in much more detail and comprehensiveness than earlier studies it takes a risk analysis perspective assessing the expected impact as a function of hazard exposure and vulnerability and consider effects at both the macro and micro level on economies health and political institutions it will model exposure to conflict events by accounting for how effects of observed overt violence are transmitted to locations far from the violence itself and over time identify conditions that make local communities marginalized groups and women particularly vulnerable to the effects and study how conflict increases their vulnerability to other shocks such as natural disasters the objective of the project is to model hazard as a probability distribution over the predicted number of direct deaths from violence in locations across the world exposure as a model for how local populations will be affected by this likely violence and vulnerability how exposure is translated into adverse human development impact for these populations the results will be coordinated in the form of a monthly updated earlywarning system expanding the wellestablished views model to also alert observers to particularly detrimental occurrences of violence throughout the project will study how the various impacts and vulnerabilities identified work to reinforce each other and formulate policy recommendations for parties seeking to reduce the impact on human development
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bioinspired uav swarm flocking guided by informationtheoretic principles
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autonomous uav swarms emerge as a disruptive technology with impact on many areas of our life from monitoring key ecosystems and hazardous environments to enabling advanced data insights however creating large decentralized uav swarms with synchronized flocking behavior and autonomous collision avoidance is a challenge this project aims to develop a holistic framework for supporting the design of uav swarms based on generic informationtheoretic principles empowerment and relevant information complemented with the bioinspired influential neighbourhood principle the key objectives are to design locally optimized control mechanisms guiding the collective motion and to provide theoretical measures for realtime characterization of swarm cohesion the influential neighborhoods theory provides an efficient strategy for maintaining group cohesion in the coordinated motion of animal groups it allows agents to limit their attention to a small subset of their neighbors reducing information processing and cognitive load and offers explicit and concise models that can be implemented directly empowerment models agents behaviour with the principle of keeping ones options open assuming that maximizing the future potential outcome of ones actions is a survivability driver in nature relevant information provides a measure quantifying the minimal amount of information an agent needs to process in order to achieve a certain level of utility identifying influential neighbourhoods dynamically will serve as a base for maximizing agents empowerment which will guide the uav swarm selforganized collective motion the integration of relevant information influential neighbourhood identification and empowerment maximization into a novel principled framework for optimizing agents decisionmaking will provide enablers for the future adaptive and scalable uav swarms maintaining swarm cohesion while manoeuvring in uncertain and complex dynamic environments
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smartaqua4future safe
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the objective of safe project is to reduce the environmental impact and improve the viability of the fw aquaculture by applying circular economy approaches to the valorisation of solid and liquid wastes from recirculating aquaculture systems ras and integthe main objective of safe project is to reduce the environmental impact and improve the viability of the fw aquaculture by applying circular economy ce approaches to the valorisation of solid and liquid wastes from recirculating aquaculture systems ras and integrated multitrophic aquaculture imta systems the economic viability of fw aquaculture will be improved through major advances in management systems and the integration of waste streams from fw aquaculture systems fwas into the aquaculture feed chain safe will enable the uptake of these solutions through local and regional scale demonstrations across the eu and will document the necessary management and governance conditions for successful transferability the multidisciplinary expertise of the consortium across a wide range of systems species and geographies will target the enhancement of species of particular biodiversity concerns such as european native crayfish we will improve the sustainability of fw aquaculture production and investigate the feasibility of diversification through the culture of underrepresented species perch and valuable crayfish species with declining populations lastly we will compare the experiences of eu fw aquaculture to chinese fwas and value chains the largest fastestgrowing and most diverse aquaculture sector in the world using mutual knowledge sharing to improve the sustainability of aquaculture in china and the eu safe through extensive dissemination activities knowledge transfer programmes training workshops and collaborative engagement with industry and stakeholders will support the development of professional skills and competencies of the fw aquaculture both within the eu and partner countries
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multiphase flow optimisation strategies with industrial applications
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efforts to reduce co2 emissions require innovative and technologically viable solutions to be developed technology holds the greatest potential to help society address the challenges of designing energy efficient concepts at affordable prices among the wide envelope of factors one core characteristic relevant to this proposal is the occurrence of multiphase flows which are ubiquitous in nature and industry for example hydraulic turbomachines ship propeller systems and efuel injectors are compromised by the occurrence of catastrophic cavitation in the field of power generation boiling heat transfer is the predominant energy conversion method multiphase flows for immiscible fluids seem to hold the key to the efficient design of emerging electrification technologies of the transport sector such as battery thermal management systems and proton exchange membrane fuel cells for innovative aviation propulsion systems as well as in the design of energy efficient marine vessels optimisation methods for designing efficient systems are largely missing from the relevant technological sectors mflops aspires to develop coupled multiphase flow and optimisation methods including adjoint methods and apply them to cases specified by mflopss nonacademic beneficiaries and partners this coupling of research with industry makes mflops a truly innovative network for doctoral researchers to start their career a holistic training is provided by scientists and industry leaders to facilitate the accomplishment of the scientific tasks and to apply them to industrial practice additional networking transferable skills and rigorous scientific training on the relevant topics make mflops a wellconnected cohort of future leaders with the ability to communicate across disciplines aiming to support european industries while been heavily involved in the public mandate for global co2 reduction
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nanoelectromechanical infrared light for industrial and environmental sensing
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the reliable and quantitative sensing of light is a fundamental task ubiquitous to modern technology the infrared ir region of the electromagnetic spectrum hosts a wealth of intriguing interactions between radiation and matter which are of particular interest for a wide range of applications including environmental biological chemical pharmaceutical and food agriculture applications because of the low energy of ir photons cryogenic cooling is required in order to reach the requisite high sensitivities in the mid and farir in our erc poc work nird we developed an uncooled ir sensor prototype based on a nanoelectromechanical system nems called nemilie which can reach unprecedented sensitivity at room temperature this radically new ir detector technology disrupts the ir detectors market with an innovative highsensitivity solution able to reduce costs and penetrate industrial markets where cryogenic cooling is uncommon and impractical opening an array of new possibilities our overall goal is to go beyond the proof of concept bring our nemilie technology to maturity and achieve market readiness thereby successfully transitioning our erc poc technology to market
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healthy soil to permanent crops living labs
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healthy soil is at the heart of the european green deal and one of the main targets of the mission board the eu is currently struggling with soil degradation which is undoubtedly linked to agriculture intensification thus a new soil management paradigm on soil monitoring restoration and protection must be an endeavour of farmers scientists businesses politicians and citizens livingsoill intends to respond to these challenges by establishing 5 living labs lls in pt fr es it and pl focused on permanent crops vineyards olive groves chestnuts hazelnuts and apple orchards comprising at least 50 demonstration sites and 10 lighthouses and with active participation of more than 2000 local actors these lls will focus on improving healthy soils and ecosystem services through cocreating coimplementing and cotesting digital solutions to reduce erosion improve soil structure reduce the impacts of the intensive use of fertilizers and pesticides increase water storage enhance soil biodiversity and the overall resilience of soil by promoting locally adjusted innovative solutions spreading sustainable soil management practices and enhancing soil literacy livingsoilll will contribute to the overall improvement of soil health and environmental resilience this approach applied in reallife settings will mobilize farmers farm advisors and local communities facilitating the assemblage of formal scientific knowledge with experiencebased farmers knowhow fostering a forum for the exchange of experiences and best practices livingsoilll is also designed to produce policy recommendations on best soil management practices on permanent crops to reduce erosion while promoting other soil health indicators with its approach livingsoill projects intends to contribute to creating the necessary conditions to eu be able to sustain healthy soils for future generations
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engaging the league of nations in protecting turkeys minorities
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the elon project aims to assess the league of nations minority protection system mps in the context of the interwar era in turkey grounded in primary archival sources this research examines the mechanics of the mps and its influence on turkeys minority policies particularly in relation to the lausanne treaty of 1923 the study augments the broader understanding of the leagues mps by bringing insights from the turkish case this research specifically delves into petitions submitted by minority individuals to the league mps adopting an interdisciplinary approach that integrates a variety of methodologies including historical and legal perspectives elons primary objectives are threefold a gather fresh data on the leagues mps operations in turkey and compile these archival materials into a minority petitions database b identify and analyse the political and legal discourses pivotal concepts and events that informed the leagues minority protection mandate on turkey including the implementation of the lausanne treaty c reassess the existing literature offering fresh theoretical insights on the leagues mps in light of data specific to the turkish context through these means the research intends to provide a comprehensive understanding of the leagues minority protection efforts in turkey placing them in the wider scope of interwar international politics and minority rights advocacy these objectives will be met through three meticulously designed work packages elon distinguishes itself as an indepth study of the leagues mps jurisdiction and minority petitions pertaining to turkey this reevaluation enriches academic dialogue and furnishes insights for addressing turkeys multifaceted challenges the specialised training and research opportunities will expand my current research and expertise and help me return to academia placing me in a prime position to pursue a faculty position
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climate adaptation and resilience demonstrated in the mediterranean region
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cardimed will introduce a framework to build climate resilience in the mediterranean biogeographical region efficiently unifying individual efforts of regions and communities across different countries and continents this will be achieved by deploying the digital infrastructure to harmonise the data collection and evaluation processes providing open data to all the actors involved in the naturebased solutions nbs value chain and integrating crucial functions for climate resilience among these functions smart digital tools for citizen participation and capacity building will supplement an ambitious multistakeholder engagement strategy focused on knowledge translation and impact pathways furthermore holistic modelling tools introducing the waterenergyfoodecosystems wefe nexus approach will provide comprehensive knowledge on the complex nbs interfaces that will decisively contribute to addressing socioecological challenges along with issues of valuation and lowinvestment rate in nbs these actions will be implemented across 9 demonstration sites composed of 10 regions 20 locations and 28 communities and comprising 47 nbs that directly relate to 83 interventions and supporting units that tackle climate change and circularity challenges the consolidation of the demonstrating regions and communities will establish the cardimed resilience alliance that will function as the vehicle for expanding the network via upscaling the existing sites and adding new ones the project includes 5 transferability cases as well as an additional 10 that will be defined during the implementation through these actions the cardimed resilience alliance will achieve at least 28 regions and 70 communities by 2030 will create 8000 jobs especially in the nbs sector and will leverage over 450 m in climate investment
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will leaf phenology keep pace with climate warming
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leaf phenology the study of the seasonal timing and drivers of budburst leaf unfolding maturation and senescence is the starting point of land carbon c cycle models driving c allocation between organs and thus largely controlling c budget estimates it is often cited as one of the largest uncertainties in future climate predictions despite centuries of research the environmental control of leaf phenology is still not fully understood stateoftheart approaches empirically relate phenophases to macroclimatic air temperature unable to capture conditions sensed by the tree microclimate or speciesspecific variability this translates into models unable to accurately reproduce forest response to climate change understanding why trees grow or shed their leaves is thus key to assessing the resilience of foreststhis project proposes a new paradigm for exploring the biophysical and ecophysiological controls of leaf phenology across scales based on a unified theory linking phenology to species strategy and the coordination of physiological processes in a limiting environment key innovations are 1 new insight into the microclimatic control of phenology through unprecedented monitoring of the budleaf energy budget 2 the identification of the key links between phenology and species strategy 3 the quantification of the colimiting factors of leaf phenology across scales accounting for environmental and physiological processes and 4 the application of a new generation of models incorporating the biophysical and ecophysiological controls of phenologythese insights are urgently needed to reduce uncertainties in c cycle estimates and to assess the response of forest to climate within the context of the ipcc these innovations will unlock several domains to which phenology is central forestry agriculture and open a realm of untapped research questions and applications that require robust forecasting of forest dynamics drought fire
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highly efficient super critical zero emission energy system
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wind and sun will be central energy sources of a climate neutral europe 2050 bringing with them the need to balance weather dependent differences between supply and load conventional gas turbines can fulfill this task also for longer periods even well as they can stabilize the grid with their capability of quick startstop however their efficiency is limited and even if burning climate neutral hydrocarbons they still produce local emissions hermes overcomes these limitations and advances gas turbine technology to the futureproof level by creating a reliable flexible zeroemission solution for energy supply with long term impact at eu levelhermes develops and assesses the first highly efficient closedloop supercritical zero emission energy system it is based on directly fired supercritical gas turbine engine operating on locally synthesized renewable liquid and gaseous fuels eg methanol or hydrogen coupled with decentralized carbon capture utilization and storage ccus the carrier medium is highly dense supercritical carbon dioxide or xenon demanding less compression power therefore and because of operating at high pressure conditions above 150 bar the system achieves significantly higher efficiency above 65 than todays gas turbines by utilizing pure oxygen for fuel oxidation and by capturing bulky flow of exhaust products h2o andor co2 and reusing them for fuel synthesis the system produces virtually no pollutants a detailed assessment of the hermes approach will be done using experimental and computational approaches and dynamic simulation tools including digital twins and machine learning the 36month project will be realized by an 11partner consortium including 3 smes with expertise in renewable energy combustion technoeconomics and sociopolitical science hermes will pave the way to a major breakthrough in the understanding of fundamentals of combustion in supercritical fluids with zero emission of any pollutants
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european startup nations alliance
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the time is now to bring europe to the forefront of the global startup ecosystem in order to boost societal health and wealth and increase economic growth especially in this period of recovery following the covid19 global pandemic the world will not be the same again and europe has a fantastic opportunity to become a global leader in the world of tomorrow if it manages to convert its potential as a continent of innovators pioneers and entrepreneurs into a competitive well organized and coordinated ecosystem of startups for that europe must establish the best framework conditions that can help the most promising and strategic startups stay and flourish in europe and grow to compete globallythe signature of the eu startup nations standard declaration in march 2021 as a formal commitment of 27 european countries to enhance these framework conditions through the adoption of best practices and now the creation of the europe startup nations alliance esna as a new startup nations hub to coordinate support and monitor national progresses towards this process are the two key elements of this european policy the present proposal is focused on establishment of esna with the mission to accelerate the growth of european entrepreneurship by improving national policy frameworks of the esna member countries on the common standards agreed upon in the startup nations standard declaration and to continuously identify and develop best practices into deployable policies based on analysis of data gathered from members on a digital platform providing up to date key information of the
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light on our dark past elucidating the deep archaeal roots of eukaryotic cellular complexity
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the origin of the eukaryotic cell with its complex and compartmentalized features represents a prime hallmark in the evolution of life on earth yet important details underpinning the emergence of cellular complexity of eukaryotic cells remain thus far unresolved current views support evolutionary scenarios in which the first eukaryotic evolved via a merger between an archaeal host cell and one or more bacterial endosymbionts recent phylogenomic work from my lab has shown that the archaeal host cell evolved from within the asgard archaea an archaeal clade uniquely displaying several eukaryotelike features however key aspects regarding the nature and biology of the archaeal host cell remain elusive limiting our current understanding of the early stages of eukaryogenesis in darkroots my team will capitalize upon our unique position and foundational results and use complementary approaches to elucidate the emergence of complex cellular features during eukaryogenesis firstly building on encouraging preliminary results we will use an advanced anaerobic cultivation infrastructure to enrich diverse asgard archaeal lineages next we will use highresolution and live microscopy approaches to study their cellular ultrastructures and cell biological properties furthermore we will monetize on recent breakthroughs in structural biology and use aiguided structural genomics to uncover new eukaryotic signature proteins in asgard archaea finally we will trace the evolution of asgard archaeal proteins focusing on homologs of proteins that give stature to the complex and compartmentalized nature in eukaryotic cells altogether building on a rich foundation of preliminary results my group will bring new pieces of the enigmatic eukaryogenesis puzzle to the table by elucidating how intracellular complexity arose during the prokaryotetoeukaryote transition
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building a comprehensive burden sharing framework to inform on an equitable implementation of the paris agreement
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methodologies for assessing the ambition of national climate pledges are in theory guiding international negotiations processes under the un to this end pledges are compared to national emissions scenarios that represent an equitable share of the global scenarios and of the effort they require to achieve the paris agreement goals these equitable national emissions scenarios do not yet inform how they can be achieved through a combination domestic action and international cooperation though transfers of mitigation outcomes as discussions move beyond pledges into action informing subnational emissions objectives and international finance in line with the paris agreement and its equity principle can help implement mitigation globallyinternationally global socioeconomic scenarios inform the costoptimal geographic distribution of mitigation effort hypothesising sufficient finance equitybased scenarios provide the total effort that each actor should provide possibly through international support the difference between the scenario sets represents international finance that developed countries can use to fund part of their fair share in developing countries subnationally state and city governments often aspire to deliver mitigation beyond their fair shares of the national targets and align with the paris agreement goal a multilevel quantitative ambition assessment framework can serve as a basis to discuss the respective roles and efforts of subnational governments as part of a country or of subnational alliancesthis project seeks to quantify 1 subnational emissions trajectories consistent with the paris agreement goals and 2 the international emissions mitigation support that each country can receive or provide to fulfil its equitable emissions scenario costoptimally the goal is to provide the most comprehensive and unified peerreviewed climate ambition assessment framework to inform climate negotiations and ipcc reports
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unveiling the functional outcome of single nucleotide polymorphisms and variants in oligodendroglia in multiple sclerosis
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multiple sclerosis ms is a neurological disease characterized by autoimmune attack targeting oligodendroglia olg in the central nervous system cns and in particular their myelin which ensheaths neuronal axons genomewide association studies gwas have led to the identification of hundreds of singlenucleotide polymorphisms snps and variants that are associated with ms risk many of these are located near genes associated with immune cells indicating a key role for these cells in ms using singlecell omics approaches we recently found that olg present chromatin accessibility or express genes associated with some of these snpsvariants both in health and disease here we hypothesize that olg have a more active role in ms than previously anticipated and therefore we will determine the function of ms snpsvariants in olg in the context of ms using humanized mouse models patient samples and new singlecell omics techniques recently developed in my group we will 1 characterize indepth the transcriptomic and epigenomic landscape of human and mouse olg in the context of ms to identify putative genes affected by the snpsvariants 2 perform crisprguided editing of a cohort of the identified snpsvariants in human olg and determine the consequences of the editing at a an epigenomic and transcriptional level linking specific snpsvariants to their bonafide target genes and b a functional level by performing an array of functional assays targeting myelination cell survival and immune function both in vitro and in humanized mouse chimeras in which engineered human olg have been transplanted we will use singlecell and spatial omics technologies such as nanocuttag and spatial cuttag among others which we have recently developed in my research group the results of this project will yield unique insights into the role of olg and the identified snpsvariants in ms and thereby pave the way to novel therapeutic avenues for this disease
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exsolutionbased nanoparticles for lowest cost green hydrogen via electrolysis
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todays alkaline electrolysers favour current densities over efficiency to achieve commercially relevant current densities these systems typically operate at voltages exceeding 2 vcell corresponding to electrolyser power consumption of 54 kwhkg there are four reasons for employing high voltages 1 electrodes insufficient electrochemical activity 2 the relatively high gas permeability of commonly employed diaphragms means that improved hydrogen purity can be achieved at high current operation points 3 the stack designs are not optimised for lowcurrent operation due to very simple flow fields and 4 high currents are required to achieve attractive electrolyser capex costs eurkw yet there is a growing consensus that the wider adoption of green h2 is not hindered by electrolyser capex the costs of green h2 are in most cases vastly dominated by opex which in turn is a direct function of electrolyser efficiency thus to achieve lowest possible levelised cost of h2 efficiency should be prioritised over current densityexsothyc will optimise electrolyser operation towards lower voltages and higher efficiencies the innovation is threefold and addressing all four abovementioned reasonsalternative pathways to the o2 and h2 evolution reactions by new anode and cathode approachesnovel concepts of membrane electrode assemblies with integrated components novel cell design to enhance overall cell efficiency by integrating disruptive conceptsin the project we adopt an approach combining computer simulations rapid prototyping and thorough experimental validation on single cell sru and short stack level in a nutshell we will combine electrodes made using powder metallurgy with ceramic nanoparticles fabricated by exsolution leveraging on the synergy that both methods require reducing atmospheres also membraneelectrode assemblies based on zirfon will be developed the cellstack will be backed by computer modelling
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trusted ai for transparent public governance fostering democratic values
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ai4gov is a joint effort of policy makers public institutions organizations legal social science and humanities and big dataai experts to unveil the potentials of artificial intelligence ai and big data technologies for developing evidencebased innovations policies and policy recommendations to harness the public sphere political power and economic power for democratic purposes the project will also uphold fundamental rights and values standards of individuals when using ai and big data technologies hence the project aims to contribute to the promising research landscape that seeks to address ethical trust discrimination and bias issues by providing an indepth analysis and solutions addressing the challenges that various stakeholders in modern democracies are faced with when attempts are made to mitigate the negative implications of big data and ai in this direction the project will introduce solutions and frameworks towards a twofold sense to facilitate policymakers on the development of automated educated and evidencebased decisions and to increase the trust of citizens in the democratic processes and institutions moreover the project will leverage the capabilities of stateoftheart tools for providing unbias discriminationfree fair and trusted ai these tools will be validated in terms of their ability to provide technical andor organisational measures causal models for bias and discrimination and standardized methodologies for achieving fairness in ai
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fastml efficient and costeffective distributed machine learning
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deep learning is an area of massive progress with myriad applications and significant industry adoption a key enabler of its progress is the ability to train large highlyaccurate deep neural networks dnns in a distributed fashion across tens to thousands of different computational nodes yet dnn training at scale poses severe challenges to standard paradigms in distributed computing existing distributed training approaches and their practical implementations via training libraries such as pytorch or tensorflow often suffer from major distribution bottlenecks which can significantly reduce computational efficiency leading to wasted time money and energythe fastml proofofconcept poc project will tackle this efficiency challenge headon by introducing a distributed training framework that will significantly reduce or even eliminate the overheads of parallelization for practical distributed training workloads in common usage scenarios fastmls distinctive feature is leveraging the algorithmic and software techniques developed by our erc starting grant in order to reduce distribution overheads at scale without impacting training convergence or model accuracy fastml stands in contrast to current distribution techniques which rely on hardware overprovisioningessentially providing very fast but also very expensive interconnects between the computing nodes as such fastml can bring significant infrastructure and running cost improvements to its users as well as lowering the cost and hardware entry barrier to training accurate machine learning models the poc will design and develop the fastml software library to target industryrelevant workloads via pilot projects jointly with our industrial partners in addition we will perform an indepth market study devise intellectual property and gotomarket strategies and produce a minimallyviable product mvp which will be demonstrated to potential customers and investors
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overcoming barriers and efficiency limitations in secure computation
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over the past few decades our use of networks such as the internet underwent a complete transformation the data that we send over the network is now routinely used in computations by third parties this creates a considerable threat to our privacy as we witness countless data breaches and companies selling our private datathe aim of secure computation is to solve this problem it studies the design of methods for computing on sensitive data without compromising confidentiality secure computation has been firmly established as one of the most promising approaches to reconcile the use of datadriven algorithms with the necessity of protecting our privacy it has spurred a considerable research effort in the past decade which has witnessed the emergence of new models such as the models of secure computation with silent preprocessing introduced by the pi and of noninteractive secure computationwhile these silent and noninteractive features are fundamental for the deployment of secure computation over large networks current protocols suffer from important downsides which make them entirely impractical in realworld scenarios they scale poorly with the number of participants and cannot be used over mid to largesize networks they either require many rounds of interaction hence are impractical over highlatency networks or trade noninteractivity for huge computational costs they induce a large communication overhead compared to executing the computation on the clear data they are often based on exotic cryptographic assumptions whose security is not yet wellunderstoodthe aim of the project obelisc is to explore the current limits of silent and noninteractive protocols and to introduce new methods for overcoming the remaining barriers the longterm vision of the project is to enable the deployment of a largescale network that further protects our sensitive data whenever it is used in distributed computation
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computational imaging through scattering materials using speckle correlation
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when viewed under coherent imaging conditions eg laser illumination scattering materials such as biological tissues create noiselike images known as speckle despite their seemingly random nature speckle patterns have strong statistical correlation properties that are highly informative of the material producing them these can be used to enable remarkable imaging capabilities not possible with current state of the art for example seeing through highly scattering layersunfortunately realizing these in practical settings tissue imaging fluorescence microscopy remains a challenge research efforts are hindered by a lack of modeling tools resulting in an incomplete understanding of speckle propertiesthis project aims to use computational techniques from computer vision and computer graphics to greatly enhance our understanding of speckle statistics and significantly expand the scope of their applicationsto this end the project will explore algorithmic tools newlydeveloped by the pi that can accurately and efficiently simulate speckle patterns to formulate better models of speckle formationwe will exploit our new understanding to develop new types of computational imaging systems that can directly measure speckle correlation rather than the traditional pipeline where one captures speckle images and estimates their correlations algorithmically in postprocessingfinally we will exploit these tools in multiple computational imaging applications including i acquiring material parameters estimating the type size and density of particles composing a material of interest ii imaging fluorescent sources deep inside scattering tissue iii adaptive optics imagingpotential impact is anticipated in numerous areas where specklebased imaging techniques hold promise including medicine increased depth penetration of tissue imaging techniques and material fabrication and analysis accurate characterization of scattering materials
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revolutionizing mirror technology to discover the dark universe
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the first detection of gravitational waves and in particular the observation of merging black holes which otherwise appear dark has been one of the most exciting scientific achievements of the last decades with the next generation of even more sensitive detectors we plan to be able to see gravitational waves from objects as far away as the edge of the observable universe however a major limitation to the sensitivity of these detectors is the thermal noise of their core components the highlyreflective coated interferometer mirrorsthe use of cryogenic temperatures will be a major step forward in thermalnoise reduction however with current coating technology the sensitivity goals of next generation detectors cannot be met not to mention further upgrades or future detector generations a all amorphous coating materials identified so far with low thermal noise at low temperatures show too high optical absorption b singlecrystalline coatings can show both low thermal noise and low absorption but come with different obstacles such as limitations on the size and material combinations or different noise mechanisms eg from bonding the coating to the mirror i plan to explore a completely new path to realize coatingfree mirrors the use of ion implantation to create a highlyreflective multilayer structure directly inside the silicon mirror substrate my main hypothesis is that the implantation procedure preserves the excellent optical and thermalnoise properties of crystalline materials which cannot be met by amorphous coatings while not imposing the limitations of singlecrystalline coatings a successful realization of such mirrors will solve the coating thermal noise issue in gravitationalwave detection entirely allowing for an unhindered view into the universe
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xray spectroscopy of molecular chirality in solutions
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the purpose of this proposal is to implement xray circular and helical dichroism to investigate the structure and chemical dynamics of molecular systems in solution the proposal entails first establishing the concepts and observables of xray dichroism in steadystate studies both in the soft and hard xray ranges and then implementing timeresolved xray circular and helical dichroism spectroscopies as probes of the chemical dynamics
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interplay of structures in conformal and universal random geometry
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my overall goal is to provide novel conceptual understanding of persistent challenges in mathematical physics in light of recent discoveries of myself and others the emphasis is especially in finding connections between different areas making use of my expertise at their crossroads the first two aims concern statistical mechanics sm and mathematical formulations of logarithmic conformal field theory cft on the one hand algebraically and on the other hand probabilistically the last two aims focus on connections and interplay of structures arising in sm such as schrammloewner evolutions sle with algebrogeometric formulations of cft gaining conceptual understanding is fundamental for progress towards deep results specifically in aim 1 i focus on cft correlation functions and plan to reveal nonsemisimple and logarithmic behavior poorly understood even in the physics literature for this eg hidden symmetries from my earlier work will be exploited aim 2 combines this with probability theory investigations of nonlocal quantities in critical sm models relating to specific cft correlation functions and to sle in aim 3 i investigate the interplay of sle cft and teichmueller theory in terms of generalizations of socalled loewner energy of curves the main objective is to shed light on the hidden geometric interpretation of loewner energy from the point of view of formulations of cft in terms of riemann surfaces and eventually also to find its role within geometric quantization to elaborate the latter goal aim 4 combines these ideas with related structures in the theory of isomonodromic deformations my starting point is the observation that loewner energy minima and semiclassical limits of certain cft correlations are both described by isomonodromic systems i plan to make these connections explicit and implement them in order to discover intrinsic features of the interplay of the aforementioned structures
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legal annotations within scandinavia
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the legal annotations within scandinavia laws research project will examine medieval legal manuscripts for notes left in the margins by readers these additions include evidence for the changing understanding of the law across the medieval and postmedieval periods the marginalia in these texts include reader reflections and erasures and i will examine these marginal annotations for insights into the ongoing reception and interpretation of the laws including the circumstances of its evolution this is particularly important because unlike the rest of continental europe medieval scandinavian legal manuscripts were less influenced by the bolognian and parisian law models and similarly the reader annotations do not follow the customary glossing patterns this provides an opportunity to examine a unique reading and legal culture that existed literally in the margins some of which will only be visible and legible now after centuries due my use of the multispectral imaging scanner at the arnamagnan institute the main objectives of my research project are therefore to 1 to examine the medieval legal texts in the arnamagnan manuscript collection for evidence of use by medieval and postmedieval readers 2 to develop a detailed record of the marginalia both standard and nonstandard present in the legal texts in order to track the changing understanding of medieval legal terminology 3 to consider the broader questions of literacy and the nordic legal cultures as seen through two important 18thcentury manuscript collections which serve as a representative sample of the time and 4 to produce an exhibition comparing the patterns of use on these medieval scandinavian manuscripts to those used read and annotated in medieval england and continental europe my research will be divided into two distinct work packages corresponding to year 1 and year 2 in the course of this i will submit two articles for publication and curate a major exhibition
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a new highperformance and environmentally clean engine for heat pumps using thermoacoustics technology
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heat pumps are the best sustainable solution for heating and cooling but they have performance limitations and are very expensive preventing them from having the desirable market tractionblue heart energy bhe has developed a disruptive patented technology based on thermoacoustics that significantly improves the performance of heat pumps with our solution heat pumps turn into flexible silent and affordable devices we do not use any hfcgases and our system is adequate for both new and existing housesblue heart leverages 15 years of rd from tno a leading dutch research organization and has been designed in close collaboration with leading oems to seamlessly replace the engine of every heat pump our scalable b2b business model will leverage the distribution channels of heat pump manufacturers ensuring a fast adoption by end customers and accelerating the energy transitionbhe has a multidisciplinary team of 15 people and is led by a highly experienced management team
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growing connection for bio ecosystems
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cobioe is project to interconnect innovation ecosystems to foster 40 industrial transition in the biopharmaceutical deeptech sector sharing competences information and opportunities with the aim of ultimately converging toward a common and inclusive european strategy for bioproduction support specifically the proposition will focus on the bioproduction sector that includes development of small molecules biologics drugs innovative therapeutics such as gene and cellular therapies high technology drugs based on cell and molecular biology and covers various applications in health oncology immunology virology rare diseases etccobioe will reach the following objectives provide a state of the art and exploitable overview of the european bioproduction value chain focusing on european national regional strategy or existing initiatives activities opening up the bioproduction field by reaching out to isolated actors and territories bringing added value to the chain building up bridges between sparse innovative ecosystems and initiatives opening up opportunities for isolated players promote bioproduction ecosystems the field and its potentialities in terms of green digital and social transition among various stakeholders and policymakerscobioe proposal includes 5 health clustersnetworks preeminent and pioneers in the field of pharmaceutical biomanufacturing each partner complements each other in terms of competence and the partnership covers almost all european regions from north to south and east to west including modest moderate strong and leading innovators moreover each partner benefits from an extended network of stakeholders from different technological sectors materials science artificial intelligence biotechnology blockchain robotics photonics electronics and quantum information and actors universities research hospitals funders
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modulating immune responses to mitigate neuroinflammation bioenergetic decrease and cognitive decline in alzheimers disease
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background and rationale alzheimers disease ad is the main cause of dementia with substantial socioeconomic burdens due to the absence of a cure understanding disease mechanisms and developing new therapies is crucial agerelated systemic and brain inflammation contributes to cognitive decline inhibiting prostaglandin 2 pge2 pge2 receptor 2 ep2 signalling has restored youthful hippocampal functions in ageing mice but its specific impact on adrelated deficits remains unclear aim we seek to explore the effect of ep2 inhibition on bioenergetic and cognitive decline in an amyloid precursor protein knockin appki mouse model of ad using neurobiology immunology and data science objective 1 we will compare the effects of brainpenetrant and nonbrainpenetrant ep2 antagonists on memory synaptic function glucose metabolism systemicbrain inflammation and amyloidbeta a pathology objective 2 we will study these effects in appki mice injected with ad brainderived pathological tau we will then assess the impact of peripheral immune modulation on adlike pathology spread objective 3 we will analyse the changes and interplay among synaptic dynamics microglial activity atau pathology progression after ep2 inhibition via realtime imaging methodology the study will involve various assessments including behavioural tests biochemical and immunohistochemical analyses multianalyte assays as well as multiomics approaches that combine transcriptomics and metabolomics additionally it will utilise two and threephoton microscopy for live imaging expected results we anticipate gaining valuable insights into a pge2ep2 inhibition effects on addriven deficits and b whether peripheral immune reprogramming restores brain functions beyond the bloodbrain barrier impact the project could yield novel mechanistic and translational outcomes guiding noninvasive therapeutic approaches to combat ad through peripheral modulations
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a vaccine targeting eradication of malaria
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malaria killed about 640 thousand people in 2020 largely young children in africa rapid recent progress has led to two antisporozoite vaccine developers planning who prequalification applications in 2022 these include the new high efficacy r21matrixm vaccine to be supplied at the required large scale and led by partners in this consortium in parallel recent progress with transmissionblocking malaria vaccines has led to substantial efficacy in a first direct skin feeding field trial this opens up the prospect of a twostage vaccine targeting both sporozoites and sexualstage parasites that should have a major impact on malaria transmission thereby enabling regional elimination and ultimate eradication we propose here to develop such a vaccine assessing both established viruslike particle vlp vaccines in potent saponin adjuvants and also exciting new thermostable mrna vaccines expressing the parasite antigens now showing high efficacy importantly we will adopt new vlp design technologies eg spycatcher bonding that allow bivalent antigen display to enable a single vaccine to protect against both the plasmodium falciparum parasite which causes most deaths and the more widespread plasmodium vivax parasite a lead vaccine candidate will be downselected based on wellstudied preclinical efficacy models and induction of functional transmissionblocking antibodies prior to gmp manufacture and a clinical trial in year 4the consortium brings together academics nonprofits and a wide range of companies with both leading technologies and access to small and very large scale gmp manufacturing capacity this programme builds on the recent success of several partners in the r21matrixm programme and aims to accelerate the malaria eradication agenda by providing the first vaccine to tackle both major malaria parasite species and confer both individual and community protection on the way to eradication
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material science innovation for accelerated sustainable and safe implementation of carbon capture and storage
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missionccs presents a timely and unique doctoral network designed to deliver the next generation of highly trained researchers and entrepreneurs in the field of material science specifically focused towards accelerating implementation of carbon capture and storage ccs technologies worldwide and ensuring the sustainable and safe operation of existing and future ccs systemsthe training network combines unique experimental system design and modelling approaches stateoftheart analytical technologies and technoeconomic analysis to deliver a new generation of researchers and entrepreneurs the programme of research training centres of delivering doctoral candidate researchers dcrs with worldleading technical expertise in material science and engineering relevant to the entire ccs process missionccs ensures that the subjectspecific technical knowledge of each dcrs is underpinned by intersectorial knowledge whilst also promoting wider innovation skills and relevant training on the technoeconomics of ccs developing experts with breadth of knowledgea central aim of the network is to forge a strong cohort culture by ensuring that peertopeer learning and mutual support become the norm in order to enhance experience researchled training activities are strengthened through a dynamic and interactive education based programme delivered by an internationally renowned consortium of academics and industrialists with complementary skills as part of the training programme subsequent to an introduction to ccs systems and the specific material science challenges dcrs will gain knowledge of system design and optimisation stateoftheart analytical methods theoretical modelling technoeconomics and understand the challenges of exploiting their research they will also acquire proficiency in project management communication entrepreneurship and innovation all essential attributes for any modern technical professional
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dried fruits as a source of prebiotic oligosaccharides and soluble dietary fiber the case study of fig
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health diets require diversification of nutrients supporting and promoting the traditional food products while keep finding new ways to their safeguard figs are nutritious and delicious products endowed with many healthbenefiting nutrients drying contributes to widen their availability diversify trade and promote their nutritive value recent research trends show that oligosaccharides os and soluble polysaccharides nondigestible by human gut enzymes are of great interest for their health benefits and natural nutraceutical value although dried figs nutritional quality has been well studied there is a lack of knowledge on the matching of the os and soluble dietary fiber sdf structural features and their potential health dietary benefits prosfig project aims at valorizing dried figs os as prebiotics and polysaccharides as sdf as an msca fellow i propose to study at uaveiro the i drying processing consumer perception and conservation of figs ii extraction and chemical characterization of dried figs os and sdf this will allow to perform a secondment at uporto to iii monitor the bioavailability and bioaccessibility of the os and sdf and their interactions with fig polyphenols and a second secondment at uminho to iv carry out in vitro assessment of prebiotic properties this interdisciplinary approach in a relevant food research topic draws a unique skill set and stateoftheart in four different but complementary fields 1 drying technology for producing healthy foods 2 consumer acceptability of traditional dried fruits 3 food biochemistry via the application of spectroscopic techniques as tools for os and sdf characterization and 4 bioengineering for evaluating the physiological aspects of os and sdf related with gut microbiota the integration in these universities dissemination and communication programs as well as in their training activities will support me to develop my career
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from research optoacoustic novelty to imaging established in routine diagnostics
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multispectral optoacoustic tomography msot is an innovative biomedical imaging technology that allows for molecular imaging in deep tissue this noninvasive technology enables assessment of the concentration and distribution of a variety of clinically important molecules in the body and uniquely delivers information of eg oxygenation inflammation and fibrotic changes msot has already demonstrated significant scientific and clinical value across a range of diseases and applications making it a promising tool to diagnose diseases and monitor treatment response despite these early successes the technology is not yet commercially viable on the broad clinical market and currently remains effectively confined to a research environment frontier will provide ithera medical the means to translate an optimized msot system msot frontier from a research environment to application in routine clinical imaging thereby providing clinicians worldwide a powerful new diagnostic tool
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safe and alternative vver european fuel
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the security of supply of vver nuclear fuel has become and will remain of vital importance in countries operating vvertype reactors and due to the strongly interconnected european grid network this is also instrumental for europe as a whole the aim of save project is to strengthen vver fuel security of supply in europe and ukraine by qualifying a reliable and safer sovereign vver440 fuel design by developing a fasttrack licensing path and improving european capabilities for vver440 fuel design qualificationthrough a strong european collaboration a large qualification campaign will be performed within european test facilities to assess the performance of the new safer and sovereign vver440 fuel assembly design save will prepare inreactor qualification with mutualised lfas lead fuel assemblies programs which will significantly accelerate design readiness for fuel reloads save will also define the plans to enable fully european manufacturing route and address the needs on core monitoring systems to initiate the next steps of development to contribute to these objectives and increase the security of supply in europe the save project is gathering 17 partners from 8 european countries within a consortium composed of experienced and highly qualified european actors in nuclear fuel and vver technologies including nuclear utilities tsos research entities leading industrial actors and universities
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multidisciplinary multisectoral and multinational training network on digital biomarkers for supraventricular arrhythmia characterization and risk assessment
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insideheart brings together universities companies and hospitals from countries italy finland france israel netherlands spain and sweden with the main scope of establishing a multidisciplinary network to tackle the design and the earlyphase validation of digital biomarkers specifically targeting the diagnosis of supraventricular arrhythmias svas and their associated potential for adverse risk assessment via the joint combination of signal processing artificial intelligence and nonclinical devices this will be achieved by performing excellent research through a unique doctoral training without walls among fieldexpert academic industrial and clinical entities the composite nature of the insideheart network ensures a highly qualified training and research infrastructure for the specific goal which aims to generate a new profile of researcher with multisectoral expertise able to fill the existing gap ie the absence of digital biomarkers for svas reliably estimated with nonclinical devices taking into account basic research clinical needs and business interests research and training are designed to consider relevant aspects such as public concern of private data management gender and ethics related to svas all according to responsible research innovation principles and open science practicesall activities in insideheart are designed to pursue innovation in three domains i educational domain by implementing a new multisectoral paradigm of phd training to shape modern professional researchers with crosscompetencies in the field and able to accelerate the translation from basic science to market and clinics ii basic science domain by producing new knowledge about digital biomarkers by means of a multisectoral approach to explore the complex aspects related to svas and iii technological domain by developing new datadriven and modelbased methodologies to compute digital biomarkers and support the clinical decision
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combinatorial and geometric methods for mapping class groups of surfaces
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given a mathematical object a common theme is to study the symmetries of that object in this project the objects are compact topological surfaces and the group of symmetries is the mapping class groupin this project we will investigate simplicial graphs associated to surfaces which have proved to be key tools in the study of both the algebraic and the geometric structure of mapping class groups studying the geometry of groups has proved to be a profound way to study their algebraic properties we will focus on a graph called the pants graph whose vertices represent pants decompositions of the surface collections of homotopy classes of simple closed curves that cut the surface into spheres with three holes the pants graph is significant not only in the study of mapping class groups but also in studying the hyperbolic geometry of surfaces and 3manifoldsthe first part of the project is to understand how distances between vertices in the pants graph are related to the number of intersections between the corresponding pants decompositions for a related graph the curve graph it is known that the distance between two vertices is bounded above by a logarithmic function of the number of intersections but the methods do not immediately generalise to the pants graph we will also investigate questions of computational complexity around computing distances in the pants graph this part of the project will include a secondment at a computer science departmentthe second part of the project is to investigate maps from the pants graph to itself which preserve distances up to bounded error such maps are called quasiisometries in a general metric space the group of quasiisometries is much bigger than the isometry group but for most pants graphs bowditch proved that the two groups coincide a property called quasiisometric rigidity we aim to prove that the same is true for three of the remaining unsolved cases
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strategic energy technology plan conference 2024
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the hungarian ministry of energy presents this proposal to host the 18th set plan conference in 2024 which will take place in hungary during the hungarian presidency of the eu the conference will be held in budapest on 1415 november 2024 and will be organized by the hungarian ministry of energy and the european commission the general theme of the conference is energy rd for resilient autonomous and competitive european energy system the agenda includes several thematic parallel sessions and high level panels as well in the following areas commercialisation of innovative technologies industrial decarbonisations geothermal energy energy storage hydrogen skills we are expecting high level speakers from the european commission and the hungarian minister of energy to open the conference the main goals of the conference are 1 enhancing cooperation and synergies between national and european policies 2 facilitating collaboration within the energy ri 3 gathering the most promising results of the energy ri
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sustainable marine energy and ecosystem resilience advancement through digital technologies and realtime crisis management
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the project aims to strengthen eu efforts towards achieving climate neutrality and achieving green energy and environmental targets seadream plays a crucial role in making sure marine energy is utilized sustainably and coastal environments are preserved in line with eu policiesthe development of a highresolution water quality data service at sea is at the core of seadreams mission data such as these are crucial to addressing specific questions regarding maritime renewable energy generation and storage the project integrates local monitoring data and advanced modeling through the development testing and demonstration of novel downstream information services in an operational mode as a result of this integration marine activities related to the generation and storage of energy are improved and environmental objectives are not compromised by harnessing advanced data and fostering collaboration across sectors the project aims to contribute significantly to the eus environmental and energy targets promoting a path towards climate neutralityin order to achieve seadreams vision a coordinated research program that thrives on collaboration is implemented in this program leading teams from academic and private sectors are seconded within and outside the eu collaborations are enhanced by periodic workshops and summer schools that disseminate the latest findings and promote marketrelevant knowledge applicationit is designed to foster the advancement of knowledge and career development for both experienced and early career researchers and professionals to ensure this secondments and training activities are structured to ensure a comprehensive approach to learning and development additionally the seadream consortium includes nonacademic partners from various stakeholder groups which facilitates direct application of project results
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deconvolving the early record of eukaryotic evolution
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the neoproterozoic era 1 to 054 billion years ago witnessed some of the most dramatic ecological and evolutionary changes in earth history which culminated in the appearance and diversification of animals after almost 4 billion years of bacterial dominance it took life on our planet just 250 million years to go from the proliferation of unicellular eukaryotes to diversification of animals this sequence of rapid ecological and evolutionary changes is thought to be related to unprecedented environmental perturbations which occurred during this time interval and are recorded in sedimentary rocks we know these perturbations did happen but not their magnitude duration or driving mechanisms one of the major limitations of interpreting the data is that each sample represents tens or even hundreds of years of sedimentation and contains a mixture of unevenly preserved remains of organisms that lived throughout this time this project focuses on new methodological approaches at the interface of organic geochemistry isotope geochemistry and palaeontology to deconvolve the mixed signals of ancient rocks stable carbon isotope analysis on biomarkers of specific groups of organisms would provide insights about the carbon cycle at their habitat analysing biomarker composition of the first complex microfossils would allow to identify which organisms they were positionspecific isotopic composition of ancient biomarkers might reveal their biosynthetic pathway and thus identify the first ecologically successful eukaryotes on our planet the study is designed to extract information about the composition and ecology of ancient ecosystems as well as the history of carbon cycle throughout the critical time of the rise and diversification of complex life it aims to resolve what it takes a habitable planet to evolve complex life and in turn how life on our planet responded to possibly the largest perturbations in the global carbon cycle in the earth history
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quantumtox revolutionizing computational toxicology with electronic structure descriptors and artificial intelligence
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toxicology is at a crossroads with ever more drugs going to market and more chemicals having an environmental impact the need for fast cheap and accurate technologies to assess toxic effects is pressing computational toxicology provides an array of tools and methods for toxicity prediction only using computer approaches conceptually computational toxicology has significant advantages since testing is fast and cheaper than in vitro however currently computational toxicology has severe limitations predictions typically use quantitative structureactivity relationship qsar models that rely on large sets of molecular descriptors this causes severe problems since the methodologies cannot assess chemicals different than the ones used to develop the qsar models and when that is possible the very large number of descriptors limits understandability therefore new methodologies are needed to address those shortcomings this project will develop a new type of descriptor totally based on quantum mechanics that can cover the whole chemical space and relies on a small number of parameters that are easily interpretable starting with meaningful chemical perturbations that extract the behaviour of the chemicals in assumed mechanisms of toxic action the approach will develop specific electronic signatures esigns esigns are mathematical invariants that map the results of the quantum chemical calculations using artificial intelligence the esigns will relate to toxicity the new approach introduces a momentous change in computational toxicology it can cover the whole chemical space since we are abandoning predictions based on molecular structures uses fewer parameters and can be related to the new trends in toxicology regarding use of pathways information in fact it is a powerful tool to allow accurate toxicology predictions solely on the basis of biochemical and chemical insight
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digital platform for datadriven and physicsbased product development enabling a circular economy
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the urgency to address the environmental impact of the prevailing linear economic paradigm has intensified stressing the need for optimizing resource utilization minimizing waste and maximizing product value to achieve ecological and economic benefits this is particularly critical in the automotive industry where a significant volume of primary materials is employed recycling scrap materials in this sector can yield impressive 85 reduction in co2 emissions however designing automotive parts for circularity requires innovative 1 tools and infrastructures to close current information gaps as well as 2 multipurpose alloys with enhanced compatibility and processibility for scrap materials to increase recyclability of materials this requires a comprehensive consideration of life cycle scenarios potential constraints on recycled material and adherence to changing standards and regulations digi4circular project tackles these challenges by creating a robust digital workflow for circular product development integrated into the synera low code platform demonstrated on aluminium casting use case in the automotive sector through automated workflows the project facilitates the generation of circular product designs and manufacturing possibilities contingent on environmental impact assessments for different endoflife scenarios the approach relies on novel methods for material design and property prediction of circular alloys rapid lca and lcc analysis knowledge extraction from norms and expert knowhow integrated by rule and knowledgebased systems for automated product design generation the workflow connects all necessary software tools and data generated throughout the value chain in a dedicated information space whereas life cycle data for individual products is systematically stored in a digital product passport accessible for all developers in the value chain
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demographic responses to varying environments under climate change
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ongoing climate change has altered both mean and shortterm temporal variability of environmental conditions such as temperature or food resources while there is strong evidence that wild populations are deeply influenced by changes in the mean environmental conditions and respond accordingly eg shifts in phenology in species ranges population responses to changes in the magnitude of environmental fluctuations are poorly understood this knowledge is however crucial to better predict and anticipate climate change impacts on biodiversity hosted at the institute of mathematics of bordeaux university of bordeaux the project drove will be coordinated by christie le coeur a specialist in population ecology who will benefit from the supervisors dr f barraquand expertise in ecological statistics and theory this project aims to provide a robust statistical and theoretical framework to unravel the effects of changes in environmental variability on dynamics of wild populations and to characterise the demographic mechanisms responsible for their persistence under climate changethis goal will be achieved by defining metrics to measure population persistence and demographic strategies in a variable but also densitydependent environment when population growth slows down as population density increases as previous work on variable environments has ignored this almost ubiquitous population regulation the researcher will then build population models with data from longterm individualbased population datasets of a wellstudied species across europe the great tit parus major to explain intra and interpopulation variations in demographic strategies and persistence in varying environments combining longterm empirical surveys with stateoftheart model development this project will provide statistical tools solidly grounded in population dynamics theory to understand environmental variability effects on wild populations under climate change
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regular and unplanned care adaptive dashboard for crossborder emergencies
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during crossborder health emergencies health and care services may be overwhelmed by high numbers of patients requiring unplanned care delays and backlogs in regular care as a result of the stretched health care system leave millions of patients with regular care needs unattended resulting in disastrous healthcare outcomes if poor healthcare outcomes across the population are to be avoided healthcare systems must become more resilient and flexible and allow for rapid changes in the care delivery services rapides aim is to develop validate and demonstrate a portfolio of powerful tools that enable healthcare systems to build in robustness of decisions resilience of the health care professionals and patients and flexibility in the modalities of care delivery thereby maintaining access to regular care during health emergencies rapide emphasises opportunities for optimising inhospital care but also for relocating care from hospitals to community and home environments without loss of care quality thus the project focuses on two closelylinked challenges 1 identifying and predicting how much care and which care needs to be moved along the care chain 2 identifying and verifying effective feasible and acceptable ways to make this reconfiguration of care a reality this will be achieved by a resource modelling which builds comprehensive foresight and forecasting solutions and links them to patient flows optimization along the whole chain of care b selecting and implementing the best available tools to deliver regular care in new ways to ensure usability acceptability and equitable realworld value rapide will be codesigned and covalidated with stakeholders from patients gps clinicians and hospital managers to health ministries pandemicmanagement and public health agencies a table top exercise and extensive communication and dissemination will raise awareness of the projects successes
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representations motives and langlands duality
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numerous advances impacting society from basic science to consumer technology are built on fundamental research in mathematics examples include noneuclidean geometry leading to general relativity and then gps navigation number theory leading to publickey cryptography and then to secure online commerce and topology with applications in image recognition and medical diagnosticsthis doctoral network remold representations motives and langlands duality will advance fundamental research in three highly active fields of mathematics representation theory algebraic geometry and number theory specifically remold is at the forefront of research in geometric representation theory and the langlands program using recent mathematical innovations from the field of motivesremold will build a european network of doctoral candidates that excels in fundamental research in mathematics implements innovative training formats and partners with a leading european quantum computing company in order to form a group of scientists ready to apply to highly competitive positions in academia and industry
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crossborder cultural and creative tourism in rural and remote areas
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rural and remote areas rra are rich in cultural heritage but many also suffer from socioeconomic problems such as an ageing population outmigration and low incomes cultural and creative tourism cct could help address these problems by creating sustainable jobs and investment but three key challenges and associated knowledge gaps must be overcome 1 placespecific business models that suit different types of cultural heritage and community needs must be created 2 tourism development must be balanced and sustainable 3 policies at different scales should support cooperation between rra crocus addresses these key challenges by a generating knowledge about which cct business models are most appropriate for different types of heritage and rural areas b creating eight crossborder living labs in which sustainable cct business models will be prototyped 16 in total c developing macroregional and crossborder policy scenarios for each of the four eu macroregions baltic sea adriatic and ionian alpine and danube and d synthesising knowledge and experience from the project to create tools and resources that rra across europe and beyond can use to develop sustainable and inclusive cct in the futurecrocus will achieve this through its ambitious multiscalar research design innovative crossborder living labs and participatory processes of sustainable business model prototyping the consortium brings together leading scholars and practitioners that have extensive experience with crossborder tourism development projects stakeholder engagement and policy analysis it will be the first systematic study of different types of crossborder cct cooperation in rra the impact of crocus will be to increase sustainable and inclusive cct and crossborder cooperation in rra across europe thus unleashing the potential of cultural heritage as a driver of sustainable innovation
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innovations and capacity building in agricultural environmental and rural uav services
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icaerus proposes an applicationoriented approach through the selection of five 5 specific drone applications to explore the multipurpose application potential of drones in agricultural production forestry and rural communities the selected drone applications represent the most important sectoral and societal drone usage purposes in europe and cover multiple applications that are interconnected within the complex rural european landscape the icaerus vision is to explore opportunities and provide a more complete and interconnected account of the potential and impact of drones as multipurpose vehicles in eu agriculture forestry and rural areas the aim is to showcase and support through application the effective efficient and safe deployment of drones as well as identify the risks and added values associated with their use taking off from the current stateoftheart in the drone ecosystem icaerus will rise up by advancing existing software technology platform components and knowledge in regard to drones to exploit the potential of drones and strengthen capacities to reduce their risks achieve better informed decisionmaking enhance sustainability performance and competitiveness in agriculture forestry and rural areas this will be showcased in two directions fundamental applications representing an eyeinthesky using the drone as a positioning system for optical observation and recording and a handinthesky applications for spraying and goods delivery icaerus plans to scaleup through research technology optimisation demonstration and education about drones to create an efficient trusted and safe enabling environment for the eu drone services market to achieve the eus decarbonisation digitalisation and resilience ambitions icaerus consists of a balanced multiactor cross sectoral and wellexperienced consortium including research organisations sme technology providers associations and nonprofit organisations
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deciphering alzheimers disease molecular subtypes to advance treatment development
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worldwide 50 million people suffer from dementia which is caused by alzheimers disease ad in 70 of the cases there is no treatment to stop reverse or prevent ad ad is pathologically defined by amyloid plaques and tau tangles in the brain implying that it is a single disease entity still patients vary greatly in rate of decline and underlying pathophysiology which hampers the search for cures i have discovered and replicated 5 ad subtypes in patients based on cerebrospinal fluid proteomics csf subtypes had distinct pathophysiology including differences in amyloid metabolism and clearance as well as in cognitive decline this indicates that they would need tailored treatmentsthe goal of this project is to understand ad subtype specific mechanisms and how these are related to cognitive decline taking csf proteomics as a starting point i will address the following scientific needs1 understand which ad subtype molecular processes change over time and how those changes relate to cognitive decline this requires large datasets of individuals with repeated csf proteomics i have access to two large deeply phenotyped cohorts with already collected repeated csf samples over 5 years from 700 individuals in which i will measure proteomics2 study drivers of ad subtypes with genetics and in a subset of n50 with tissue proteomics3 develop markers in blood for subtype detection which would remove barriers for clinical use4 test if ad subtypes differently respond to amyloid modifying drugs which is the strongest proof that ad subtypes need tailored therapyif successful decipherad will provide proof of concept that ad subtypes have use as a theragnostic tool show which genetic factors drive molecular subtypes how molecular signatures change over time and how these changes relate to cognitive decline with tools in blood to facilitate implementation in clinical practice this will catalyse ad subtype tailored treatment development
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adaptable bioinspired polaritonpolariton energy management
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humanity is approaching a cornerstone where climate change will transform society industry and economy therefore moving away from inefficient energy consumption and fossil fuels is more urgent than ever renewable energy sources are growing fast but their full integration will make necessary not just a boost of their efficiency but rather a quantum leap in energy management such paradigm change will come from technologies adaptable to changing climate conditions and importantly making use of widely available noncritical materialsadaptation vision is to challenge current paradigms in solar energy harvesting and their integration by developing a new solar material platform that will integrate thermal management and energy collection in a single material reducing electricity peak profile and allowing easy adaptation of the energy harvesting properties to different climate conditions for this purpose we will take inspiration from the two most efficient energy management processes on earth photosynthesis and terrestrial radiative cooling adaptation will mimic simultaneously the strategies followed by plants during photosynthesis to collect and manage energy at the nanoscale and the powerfree radiative cooling of earth by thermal regulation at the microscale these extraordinary energy collection and managing strategies are robust to disorder and provide selfregulatory cooling capacities which make them ideal to be integrated into a wide spectrum of physical objects powering them with a sustainable energy source in adaptation we will develop the building blocks for this technology and will demonstrate its implementation with two sustainable novel device architectures our innovative vision is based on the multidisciplinary background of its consortium with experts in geosciences polaritonic photonics colloidal and supramolecular chemistry materials engineering quantum technologies or photovoltaics including hightech industrial implementation
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carboxylic acids as reactive refrigerants to make heat pumps efficient
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aiming to contribute to a substantial increase in the sustainability of thermal power plants heat pumps and climatization systems the ercstgreacher is introducing new working fluids for the thermodynamic cycle underlying these systems these new fluids are mixtures of dimers a2 and monomers a undergoing a reversible dimerization reaction a2 2 a evolving instantaneously and spontaneously in the unit operations of the machine reacher has introduced about 200 of these reactive fluids among them the family of carboxylic acids eg formic acetic propionic acid seems very promising as working fluids for residential heat pumps other than owing excellent environmental properties their use promises an outstanding 1743 relative efficiency improvement compared to stateoftheart heat pumps in this context the main objective of the ercpoccreative is to perform the first step towards the realisation of a residential heat pump prototype operating with formic acid enabling the validation of the theoretically observed positive chemical reaction effects this step consists of preliminary verifying the feasible compression of formic acid with a finely controlled series of available compression technologies using air as working fluid in the subatmospheric pressure conditions characterising operation with formic acid within creative these results will further allow the design of a pilot operating with formic acid to test in a future poc the compressors preliminarily selected and pretested with air in creative the realisation and design of the experimental setups for the formic acid compression feasibility assessment are supported by thermodynamic calculations carried out in creative using tools developed in reacher this poc is supported by the expertise of two industrial partners and involves the host institutions technology transfer office which will handle ip management and explore valorisation pathways for the key exploitable results
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a realtime imaging and classification system for lowgrade glioma detection during brain surgery
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brain tumors remain one of the most incurable illnesses we know patients have poor prognosis and less than a decade of life expectancy the oncologists toolkit is rather limited as chemotherapy agents have limited access to the brain due to the blood brain barrier selective permeability and radiotherapy results in extensive damage to tissue well beyond the targeted area leaving surgical removal of the tumor as the most effective approach it has now become clear that the completeness of the surgical removal of the tumor is the most important factor determining recurrency of the illness as such tools that enable neurosurgeons to effectively remove the tumor are of fundamental importance in the surgical theater recent advances in intraoperative fluorescent labeling of common brain tumors has proven to dramatically improve surgical outcome unfortunately no such labeling or intraoperative aid exists for the highly infiltrative lowgrade glioma lgg making it the deadliest type this poc project aims to tackle this urgent unmet need and develop an intraoperative realtime imaging and tissue classification tool for precise onsite identification of lgg tissue the core technology emanates from the multiphoton ultrafast volumetric imaging we developed now able to run in realtime to study the link between neuronal activity and blood flow here we harness this unique technology and extended it to perform realtime labelfree multimodal acquisition and image processing using the latest deeplearning tools our tool will provide surgeons with the ability to discern while operating healthy vs tumor tissue together with neurosurgeons a technological hardware partner and an expert in artificial intelligence we are positioned to generate the firstofits kind prototype and to seek its commercialization such a tool is expected to become a game changer in brain and other tumor surgeries improving the life expectancy and quality of many patients and families
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the experience of poverty in the postindustrial economy
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the reduction of poverty is of societal importance after advances in the study of poverty in the late 20th century however most highincome countries have settled on an annual measure of household income as their primary measure of poverty in contrast exppov argues that shifting socioeconomic conditions in recent decades necessitate a new conceptual approach for understanding poverty and a new methodological framework for the collection of data related to the experience of poverty specifically exppov confronts four central tenants of poverty research first in contrast to national or regional investigations of poverty exppov proposes that the geographic distribution of poverty across neighbourhoods within a municipality is an understudied yet important source of stratification that directly affects wellbeing second this project expands measurement of the dimensions of poverty to incorporate physical and subjective wellbeing confronting the incomespecific approach that dominates the field third exppov measures the dynamics of poverty throughout the year to understand the sources and consequences of monthtomonth volatility in poverty fourth in contrast to the practice of identifying poverty as an outcome of the family market and state this project proposes that the dynamics dimensions and geographic distribution of poverty are direct sources of the morefractured family structures precarious jobs and tenuous welfare states that define postindustrial economies from a data perspective exppov introduces tools to produce lowcost panel surveys with the ability to target respondents in particular postal codes and working for specific employers such as uber or deliveroo methodologically exppov introduces a framework to evaluate the contextual effects of poverty on the core institutions of social life conceptually exppov will reset the fields understanding of the social mechanisms through which poverty is experienced and reproduced
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targeting dna damage response and metabolism for precision medicine in rheumatoid arthritis
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rheumatoid arthritis ra is an autoimmune disease that affects millions of people worldwide and its negative health burden is accelerating in the ageing population despite many available treatments up to 40 of ra patients do not respond sufficiently to current therapies and the needs for a precision medicine approach and new treatments are pressing the complexity of ra and unselective mechanisms of action of existing drugs are challenges current treatments also have unintended adverse effects because they affect healthy cell types in the body the proposed project ddrastic focuses on a particular enzyme called mthfd2 which plays a crucial role in the metabolism of folate and dna damage response of activated t cells recent research and preliminary data suggest that mthfd2 is overactive in ra patients ddrastic aims to address the hyperactive tcell responses at the core of ra by targeting mthfd2 with novel inhibitors that spare essential components thereby minimizing the risk of toxicity and adverse effects in parallel ddrastic seeks to understand the underlying reasons for the limited efficacy of current ra treatments and explore potential biomarkers that can predict how patients will respond to standard therapies with a specific focus on understanding the involvement of mthfd2 the aim is to introduce a precision medicine approach in ra and identify a novel treatment to achieve this ddrastic adopts a multidisciplinary approach and uses patientderived specimens ra animal models and bioinformatics analysis from large cohorts of ra patients to undergo advanced imaging cellular and molecular techniques overall these analyses aim to provide insights into mthfd2s regulatory role in abnormal immune responses and advance ra treatment by introducing precision medicine approaches and overcoming treatment toxicity
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multilingual and multicultural spaces for political deliberation
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as highlighted by the conference on the future of europe eu citizens at large feel that the interplay between national media discourse and politicalcultural contexts affects the perceptions and reactions to global events differently language barriers exacerbate siloed thinking the bandwagon effect group thinking and the lack of diversity in dialogue around issues of international relevance creating areas of thinking entrenched into national and language gates and hindering the creation of a truly european public sphere such challenges to democratic participation disproportionally affect members of cultural and linguistic minorities within and across eu member states the research and innovation roadmap of the multipod project aims to radically improve the political dialogue at the european level through evolving knowledge graphs and generative artificial intelligencedriven technologies that mobilise collective intelligence bridge existing communication barriers and yield a better understanding of the interdependencies between participatory processes policy decisions and behavioural thought and argumentation patterns in the public deliberation of international affairs for this purpose multipod brings together experienced use case partners as well as european networks engaged in fostering participatory deliberative democratic processes technology partners with a strong track record in multilingual language processing and leading research partners specialised in collective intelligence argumentation theory humancomputer interaction and visual methods for supporting and analysing online communication
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analysis of and responses to extremist narratives
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social protest movements the covid19 crisis and the war in ukraine have triggered increased polarization of debates they have challenged european democracies and thus fostered extreme narratives with strong and numerous consequences for citizens politics and the democratic exercise the arenas consortium focuses on the narratives as crucial nexuses because the battle of stories not the debate on issues cornog 2014 can determine the way that citizens react to political events a strong antagonism is constructed between extremist and mainstream narratives which is evident if we compare the narratives on the ongoing war in ukraine extremist narratives always reflect the complex intersection of spatial and temporal context where the narratives are constructed circulated consumed and reproduced they are characterized by their reliance on pathos and emotions as well as the importance of violence in them they tend to proliferate in historical periods characterized by social turmoil and construct an alternative reality and promote negative emotions and behavioral patterns that run against mainstream and official narratives in social media and through the connections between social and traditional media extremist narratives are naturalized and have an impact on mainstream narratives arenas will provide concrete responses to the consequences of these extremist narratives by i measuring and mapping the spread of extremist narratives ii defining remediation actions for individuals and groups affected by extremist narratives iii providing educational and institutional propositions to anticipate future challenges in terms of the construction and circulation of extremist narratives and iv identifying multilevel policy recommendations to help counter extremist narratives both at the institutional and political level and at the level of associations and citizens
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terahertz reconfigurable metasurfaces for ultrahigh rate wireless communications
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the sixth generation 6g of mobile communications planned around 2030 is expected to support innovative applications with requirements not met with todays technologies such as massivescale communications within iot the internet of senses holographic communications massive digital twinning and extreme reality full autonomous driving and flying networks considering use cases in smart cities smart home and factories eg ultrahigh precision 3d positioning with the emergence of viable thz communications systems on the horizon it is crucial to contribute thz communication and networking to the technology roadmap for beyond 6g timeframe and a step closer to industrial uptake the terrameta project aims to investigate revolutionary technologies for 6g and demonstrate the feasibility of terahertz thz reconfigurable intelligent surface ris assisted ultrahigh data rate wireless communications networks novel highperformance hardware including the thz ris and thz transmitterreceiver will be developed and advanced network analysisoptimizations techniques will be developed using these real thz components the proposed terrameta thz network will be driven by 6g usage scenario requirements and indoor outdoor and indoortooutdoor scenarios will be demonstrated in real factory setting and telecom testing field it is expected that the outcome of this project will significantly progress innovations for across the 6g technology and systems
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quantum dynamics of floppy systems beyond coulomb interactions magnetic and parityviolating effects
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chemistry is developed with the improvement of experimental and theoretical spectroscopy a wellknown approach for molecular vibration is based on harmonic oscillators but it cannot be used for floppy systems to analyze spectra of floppy systems the exact quantum dynamics qd methodology based on a numerically exact solution of the rovibrational schrödinger equation has been developed it may appear that rovibrational spectroscopy is well established based on the electronic schrödinger equation with coulomb interactions but two additional effects that split molecular spectra remain a magnetic interactions due to nuclear spins and b parityviolation interactions which is due to the electroweak force causing tiny energy differences between enantiomers the magnitude of a is on the order of several tens of ghz 109 hz which is observable in the highresolution spectrum the magnitude of b of a current target molecule is predicted about a few mhz 103 hz which is smaller than the current precision of the best experiments the suggestion of new target molecules with large pv effects is required these effects have been investigated for rigid systems but never for floppy systems where new coupling of rovibration and magnetic interactions and strong enhancement of pv effects may be present in this project i investigate a and b of floppy systems by developing new qd methodology and by obtaining molecular properties spinrotational constant and pv energy based on electron correlation theory the objectives of this project are as follows i formulation implementation and application of qd with magnetic interaction for floppy systems ii theory development of qd for methanollike molecules and iii qd application for chiral methanollike molecules this project provides the development of the exact quantum dynamics methodology which leads to a complete description of quantum nuclear motion in molecular systems
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salt hydrate heat pipes a breakthrough in thermal energy transfer methods
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heat pipes hps are one of the highly efficient passive devices used for heat transfer from one place to another recent hp technologies have shown auspicious results in several applications especially where there is limited space and the necessity of high heat flux such as in aerospace and automotive industries cooling of computers cell phones fuel production hvac systems and renewable energy systems although hps offer acceptable ranges of thermal efficiencies today achieving higher efficiencies could make a revolution in their applicability making them a dramatically more effective tool for the mentioned applications and even many others hence this project proposes a firstofitskind and revolutionary approach for the performance enhancement of heat transfer tools especially in hps the method centers around the use of salt hydrate sh materials with positive enthalpy of dissolution as the working fluid the project pursues several specific research objectives including 1 developing the first shhp using the primary choice material of nh4no3 2 finding and testing potential alternatives for the benchmark material 3 thermal and flow simulation cfd of hps in various designs with the selected materials as working fluid 4 thermal behavior optimization of the shhps 5 experimental verification of the modeling results on the shhps in the lab and 6 carrying out a risk analysis life cycle cost and life cycle assessment of the developed hps it is expected that the enhancement to be made in hps design and performance could be advantageous for a wide range of thermal energy systems especially those for the exploitation of renewable energy eg geothermal systems solar evacuated collectors etc
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uncovering molecular and cellular mechanisms of immune cell trafficking across the bloodcsf barrier in autoimmunity
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immune cells continuously traverse our body crossing vascular and epithelial barriers from lymphatic organs into the blood and from the blood into various tissues for surveillance or to fight infection however the brain has long been considered an immuneprivileged organ barriers protecting the brain against infection or harmful toxic agents were also thought to block entry of immune cells leaving immune functions to brainresident microglia cells this dogma was recently overturned when it became clear that immune cells cross mainly for surveillance especially at the bloodcsf barrier furthermore while harmful immune cell trafficking is a hallmark of brain autoimmunity eg multiple sclerosis and neurolupus enhanced trafficking might help to fight brain tumours and even to resolve neurodegenerative conditions eg alzheimers disease yet the study of immune cell trafficking across the bloodcsf barrier is severely hampered by a shortage of suitable methodologies we investigated bloodcsf barrier dysfunction in lupus and discovered a brain lymphoid structure with enhanced immune cell trafficking dominant transepithelial leukocyte migration through rather than in between cells will enable us to catch the trafficking events redhanded and to identify molecular and cellular trafficking mechanisms harnessing innovative methodologies involving singlecell rnaseq superresolution microscopy imaging cytometry and geneticpharmacological interventions we aim to decipher the fundamental question of how leukocytes enter the brain we will classify specialized immune and epithelial barrier cell types identify trafficking molecular pathways and develop approaches to regulate the process we will also assess this barrier involvement in the pathobiology of human neurolupus diseaseunderstanding immune trafficking mechanisms may be the key to a specialized brain portal leading to therapeutics that can modulate brainimmune interactions
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nondestructive scalable smart monitoring of remote cultural treasures
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argus draws on the current challenges in monitoring remote built heritage assets and the current research focus on preventive preservation and envisions the development of a a novel built heritage digital twin model to support multiscalemodal data b an advanced digitisation strategy to support the digital twin model c a portable measurements system for nondescructive physical and chemical monitoring based on miniaturised sensors and sensor composites integration comprising of ground and aereal components d aienabled methods for the modeling and identification reverse engineer of threat factors and their impact e aipowered multimodal data methods for the fusion of i remote sensing climate weather and pollution data with ii natural disaster regional statistics iii governmental statistics ii onsite acquired measurements f trustworthy ai decision support methods for the preventive preservation of built heritage argus innovation targets a researchersacademics data from the argus monitoring systems longterm status processed data the novel multimodal digital twin white paper multidimensionalmodal data visualisations apis b stakeholdersheritage managerspractitioners realtime monitoring longterm status analysis predictive preservation predictions intervention decision support c authorities realtime monitoring longterm status analysis predictive preservation strategies d general public realtime visualisations crowdsourcing and citizen contribution in preventive preservation citizensintheloop ri design with living labs and hackathons
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peripheral biomarker based combinatorial early diagnostics for dementia
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combidiag dn aims to develop an aidatadriven peripheral biomarker based combinatorial diagnostic protocol for early stages of alzheimers disease ad a major form of dementia and to train a new generation of fellows for this interdisciplinary field dementia a devastating disease of older age is the challenge of our lifetime and one of the societal challenges listed by the un sustainable development goals and horizon europe combidiag responds to this challenge to establish a muchneeded dn to carry out an integrated study of minimally invasive and costeffective peripheral biomarkers including body fluid markers from blood urine and saliva and digital markers from speech motor functions and sleep for developing the combinatorial early ad diagnostics the consortium comprises nine academic and eight nonacademic institutions across europe usa canada and china it synergises leading academic and industrial experts worldwide to build a triplei research and training platform for the training of a new generation of fellows to take early ad diagnostic research to a new level fellows will be trained under the vitae researcher development framework innovatively combined with the combidiag platform for triplei scientific and transferable skills as well as personal quality creative thinking and business mindset the dn has a highly innovative research programme for the discovery of peripheral ad biomarkers detection techniques aidata driven technology clinical validation and integration into trial designs the advances in combidiag research will enable a case finding tool at primary care level for helping achieve improved drug discoveries diseasemodifying treatments preventive strategies and care provision for ad combidiag will deliver 10 highlyskilled creative and entrepreneurial fellows setting them on a path to successful careers in academia or industry to ensure that the medical and societal challenges imposed by ad are met
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innovative photodetector module for advanced hybrid magnetic resonance imagingpositron emission tomography scanners for nuclear medicine
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the development of modern methods of medical diagnostics is an integral part of the work and research of scientists and it is constantly being improved as highprecision early diagnosis increases the chances of recovery for people suffering from dangerous diseases one of the key developments in this area is a new hybrid pet mri machine that provides simultaneous magnetic resonance imaging and positron emission tomographythe successful implementation of the project will be ensured by a coordinated exchange of experience and knowledge gained in the field of physics technology and engineering by strengthening modern knowledge in the field of optoelectronics and applying modern technological approaches and methods as well as international cooperation of highly qualified scientists and engineers from portugal czech republic turkey ukraine azerbaijan and russia this consortium will assess both technological for example development and production of highly sensitive detectors and fundamental mechanisms of internal amplification of ultraweak photosignals issuesthe project participants have many years of experience in the development of semiconductor optical devices research of detection methods the successful implementation of this project will lead to the scientific development of highsensitivity detectors of a new generation and as a result to the creation of advanced detection devicesthe aim of the project is to develop a highly sensitive prototype of a detector module for a new generation of petmri scanners within the framework of this project the collaboration will carry out both research and technological components through multipurpose business trips
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the influence of schools on the offtime transitions to parenthood and partnership
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becoming a parent and moving in to live with a partner are major life events determining individuals life chances and outcomes transitioning to parenthood and partnership at very young age also called offtime transitions have been linked to adverse outcomes along the life course a potentially key influence on offtime transition to parenthood and partnership are secondary schools and classmates as adolescents spend a large part of their time in school surrounded by their peers project schoolandtransitions will be the first to investigate the role of secondary schools and classmates in offtime transitions to parenthood and partnership this project aims to gain a complex understanding of the influence of schools and classmates and its interaction with individuals characteristics and family backgrounds to achieve this i set three objectives 1 decompose the effect of the school as a social context and the effect of peer influence of classmates 2 examine if and how can classmates and school contexts mitigate or exacerbate the influence of family background and 3 assess how the effect of classmates and school contexts changes over the years since leaving the secondary school
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ultrasonic guided wavebased ndt of hydrogenloaded pipelines
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hydrogen is seen as secure clean and inexpensive energy of the future to this aim the european union has laid out strategies for largescale production and deployment of hydrogen in the future this translates to the most economical way of transmission of hydrogen through existing natural gas pipelines however one of the serious issues that can present a setback to this ambitious project is the failure of pipelines due to defects one such lessaddressedhardtodetect failure mechanism called hydrogen induced cracks hics is considered for the proposed work in order to detect hics in hydrogenloaded gas transmission pipelines an ultrasonic guided wave ugw based ndt technique will be developed towards this a torsional guided wave mode will be optimized for its frequency from the perspective of defects hics in pipe segments using the scaled boundary finite element method sbfem simulation tool available at bam an array of shear mode piezocrystals for the optimized frequency will be used in the generation of the torsional mode towards ugw based testing pipe segments with actual hics will be prepared at hydrogen test rig at bam under the guidance of bams material scientists additionally pipe segments with artificial notches simulating hics will also be prepared further laserbased measurements will be carried out to map the wave fields around the crack to understand the physics of wavedefect interaction further the effect of operational conditions of a pipeline such as pressure and temperature on torsional mode will be studied using both experiments and simulation overall the project will involve both simulation and experiments to gain deeper understanding of the problem emphasis is also given on the validation of simulation results for the smooth progress of the project furthermore ultrasonic phased array testing will also be carried out to successfully validate the ugw measurements pertaining to defects and to localize and size them
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towards a functional continuum operating system
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the unstoppable proliferation of novel computing and sensing device technologies and the evergrowing demand for dataintensive applications in the edge and cloud are driving a paradigm shift in computing around dynamic intelligent and yet seamless interconnection of iot edge and cloud resources in one single computing system to form a continuum many research initiatives have focused on deploying a sort of management plane intended to properly manage the continuum simultaneously several solutions exist aimed at managing edge and cloud systems through not suitably addressing the whole continuum challenges though the next step is with no doubt the design of an extended open secure trustable adaptable technology agnostic and much more complete management strategy covering the full continuum ie iottoedgetocloud with a clear focus on the network connecting the whole stack leveraging offtheshell technologies eg ai data etc but also open to accommodate novel services as technology progress goes on the icos project aims at covering the set of challenges coming up when addressing this continuum paradigm proposing an approach embedding a welldefined set of functionalities ending up in the definition of an iot2cloud operating system icos indeed the main objective of the project icos is to design develop and validate a meta operating system for a continuum by addressing the challenges of i devices volatility and heterogeneity continuum infrastructure virtualization and diverse network connectivity ii optimized and scalable service execution and performance as well as resources consumptions including power consumption iii guaranteed trust security and privacy and iv reduction of integration costs and effective mitigation of cloud provider lockin effects in a datadriven system built upon the principles of openness adaptability data sharing and a future edge market scenario for services and data
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generating a 3d micro necroptosis induced myocardial infarction model
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cardiovascular disease remains one of the leading causes of death worldwide with more than 4 out of 5 of these due to heart attacks following a myocardial infarction mi the loss of cardiomyocytes cms is irreparable due to their nonproliferative state following a mi one of the most promising forms of recovery is using therapeutic drugs since generating a new drug requires considerable amounts of money and animal testing there is a need for alternative models such as human induced pluripotent stem cell hpsc models hpscs provide an excellent platform to model cardiac disease although 2d models are too immature and currently 3d models are not viable for screening of therapeutic compound libraries to solve this i aim to implement a kill switch in a subpopulation of a 3d cardiac tissue that when triggered will induce necroptosis in the population simulating a localized heart attack integrating macrophages will improve the physiological relevance and ctntfucci cms will be used to monitor cm proliferationto generate this innovative dependable inducible model of mi using hipscs the project is divided into 3 achievable goals1generate a hpsc cell line with inducible kill switch system2integrate macrophages into microtissues induce the kill switch investigate response to localized cell death and cellular changes producing a scrnaseq timeline3incorporate ctntfucci cardiomyocytes to investigate cardiac regenerative therapiesi will receive stateoftheart genetic modification training to generate the cell line goal 1 immune cell generation and integration goal 2 and bioinformatic study to identify key pathways identified through scrnaseq data generated from the minimi model to trial cardiac regenerative compounds goal 3 this project will not only generate a reliable model of mi capable for screening of cardioprotective compounds but also a malleable model suitable for easy adaptation to other researchers interests
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strengthening global cooperation and institutional capacities in subsaharan africa to facilitate implementation of the gh edctp3 programme
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this proposal is in response to the gh edctp3 call for support to edctp africa office ao which is part of the edctp association secretariat based in cape town and hosted by the south african medical research council the aim of the proposal is to provide support for the operation of the ao to ensure optimal implementation and visibility of the gh edctp3 programme in ssa the ao will provide technical support promote networking activities southnorth southsouth ensure alignment of the funded activities strategic partnerships and increase visibility of the gh edctp3 this aim of the project will be achieved through several activities that include technical support for the design implementation and monitoring of capacity developing activities monitoring funded projects organising workshops and facilitating dialogue between african and european research entities and stakeholders the expected impact is a strengthened and improved delivery of the gh edctp3 programme in ssa the implementation of this proposed project will be structured into four work packages wp called project management wp1 capacity development and networking wp2 strategic partnerships wp3 and conferences forums and meetings wp4 through this grant the ao will contribute to the following impacts accelerated product development for fighting target infectious diseases facilitated preparedness against public health emergencies in line with one health increased visibility of aueu partnership in science ensured close alignment with ssa national research programmes and activities on target diseases and ri increased participation of ssa countries in gh edctp3 and increased participation of industry and private entities in product development and clinical trials in ssa to implement the project fully the ao will need a competent project coordinator four project officers a senior administrative officer and an office manager the project will be 2953000 euros
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how do people perceive the 15minute neighbourhoods globally investigating public perception across developed and developing worlds
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over recent years the novel concept of the 15minute city is gaining traction across europe and beyond due to the numerous benefits that it can yield for local communities although it builds upon previous urban planning movements and ideas repackaging them has contributed to extra attention when reinventing the desired neighbourhood structure at this time of global resource constraints climate change vulnerable settlements pandemics and social exclusion the concept promotes a proximitybased approach in neighbourhoods planning and design by which accessing daily needs for locals is guaranteed in a 15minute walkbicycle ride of their home while the fundamentals of the concepts are promising a prescriptive nature like its previous counterparts does not allow for understanding how popular it is for people and replicable across various contexts in fact much less is known about the applicability of this new approach with regard to diverse contexts and clients the present research project will thus shed light on exploring the way people perceive this novel planning and design approach in various urban contexts worldwide this research follows a casestudy design with an indepth analysis of public perception that is based on a combination of qualitative and quantitative methods the empirical study on contextsensitivity is conducted using predefined developed and developing cities represented by brussels and tehran respectively these findings contribute in several ways to our understanding of the 15minute city concept and provide a basis for future applications having multiple scientific social and environmental impacts on global communities in long term
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breakthrough dualaction otc tablet for treatment and prevention of both bacterial and fungal vaginitis
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there is a large unmet medical need for an efficient and highly accessible solution that can simultaneously treat and prevent bv and vvc while removing the abuse of antibiotic and antimycotic drugs to avoid further antimicrobial resistance the inefficacy of current solutions is demonstrated by the huge burden that bvvcc bring to the society in terms of economic expenses more than 38bn annually preterm births 54m per year the huge prevalence of both diseases more than 500m cases per year and the deteriorated qol for women gedea has developed phyph a patented pessary that due to its safe profile will be highly accessible as a first line otc solution phyph is an antimicrobialfree dual solution with a new mode of action that targets both the treatment and prevention of bv and vvc without the need of pathogen identification phyph will be commercialized as an otc product in pharmacies and drug stores where 90 of women with vi look for a treatment to the infection the business model targeted for phyph is a wellestablished and successful b2b2c model for this type of product our business model is highly scalable via planned partnerships with distributors and pharma companies that will facilitate accelerated commercial deployment scale up of our business throughout europe beyond gedea core team is composed by 9 persons with over 250 years of experience combined including experts in clinical research bioorganic chemistry regulatory affairs marketing and business development the company received the award rapidus company of the year and appeared on labiotechs list the 20 european biotech companies to watch in 2022during this project gedea will perform the necessary clinical trials cemark certification and premarket activities to commercialize phyph trl 9 by 2026 in order to do so gedea requires an estimated expenditure of 119m which is requested to the eic through both grant and equity fund
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revealing the mechanics of subcritical rock cracking of mountains cliffs from environmental forcings by imaging stress cycles from dense acoustic arrays
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the general idea that a rock mass cracks when the external stressloading exceeds the rock strength leading to catastrophic failure critical cracking is challenged when considering outcrop erosion many observations in the field and the laboratory evidence slow incremental crack developments well below the yield stress of the material for which repetitive stress load and fatigue induce progressive failure also called subcritical cracking it is largely accepted that the weather temperature changes rain frost is a major source of stress cycles and slow cumulative damage but the literature shows too limited quantitative field observations to confirm the mechanics behind rock outcrop cracking today we cannot predict rockfalls nor quantify the relation between daily or seasonal weather forcings to rock crack production and yet rock fracturing plays a leading role in most surface processes from landscape building to vegetation hydrology and natural hazard prediction there is an urgent need to reveal the mechanics of subcritical failure within rock outcrops fracturing processes initiate and develop at small scales from the grain size to a few mm and meteorological forcing evolve over daily to seasonal time scales but existing field observation tools hardly meet these scales in order to lift this issue the project will deploy an original active multisensory acoustic imaging technique on natural rock outcrops to map and monitor stress changes and crack production in m2m3time over timescales ranging from a few hours to a few months with a centimetric spatial resolution and a stress sensitivity down to a few kpa stress will be deduced from acoustic waves thanks to the acoustoelasticity principle allowing us to determine the physics of subcritical cracking of rock outcrops in their natural environment this work will pave the way for predicting rockfalls and further the impact of climate change on rock erosion
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the age of age the rise of calendar age and sociopolitical age consciousness in early modern germany and italy c 1650 to 1850
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modern western societies have coalesced around one way of thinking about human age calendar age ie the number of years since birth which shapes both how we think about agerelated behavioural norms and how we define for example access to retirement benefits despite its unrivalled importance calendar age has come under critical scrutiny amid recent debates on ageism in line with historical notions of gender or class it becomes increasingly clear that calendar age is not a neutral number but an impactful social categorywhen did calendar age rise to become such ubiquitous category and which factors contributed to this how did early modern age consciousness function before the rise of calendar age the project studies these two questions at the example of southern germany and northern italy between 1650 and 1850 based on a sample of burial records it shows how between the early enlightenment and the onset of the industrial era reporting ones age in calendar years became increasingly common as calendar age grew into a category to identify people driven by enlightenment notions of accuracy a significant share of early modern populations could report their age in calendar years this rise of calendar age supplanted an early modern age consciousness in which alternative ways of age reporting coexisted and whose degrees of accuracy depended on the specificities of context the project studies one such context to show how early notions of accuracy were culturally motivated and how information about birthdates and baptisms could actually be retrieved to enter guilds in early modern italy and germany young men had to prove their legitimate birth forcing them to research its circumstances and provide written documentation this production of birth certificates will be analyzed by comparison of an german and italian city by historicizing calendar age the project contributes to the fight against ageism and reflections on agebased norms
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hybridelectric regional architecture
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hera will identify and tradeoff the concept of a regional aircraft its key architectures develop required aircraftlevel technologies and integrate the required enablers in order to meet the 50 technologybased ghg emission set in sria for a hybridelectric regional aircraftthe hera aircraft having a size of approximately of 50100 seats will operate in the regional and shortrange air mobility by mid2030 on typical distances of less than 500 km interurban regional connections the aircraft will be ready for future intermodal and multimodal mobility frameworks for sustainabilitythe hera aircraft will include hybridelectric propulsion based on batteries or fuel cells as energy sources supported by saf or hydrogen burning for the thermal source to reach up to 90 lower emissions while being fully compliant with icao noise rules the hera aircraft will be ready for entry into service by mid2030 pursuing to the new certification rules able to interact with new ground infrastructure supporting new energy sources this will make hera aircraft ready for actual revenue service offering to operators and passengers sustainable safe and fast connectivity mean at low ghg emissionshera will quantitatively trade innovative aircraft architectures and configurations required to integrate several disruptive enabling technologies including high voltage mw scale electrical distribution thermal management new wing and fuselage as well as the new hybridelectric propulsion and related new energy storage at low ghg to support this unprecedented integration challenge hera will develop suitable processes tools and simulation models supporting the new interactions workshare in the value chain and interfaces among systems and components hera will also elaborate on the future demonstration strategy of a hybridelectric regional aircraft in phase 2 of clean aviation to support the high trl demonstration required for an early impact for hera solutions
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