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upgrading business potential of enzybiotx
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since the discovery of penicillin people were living in justified confidence that available antibiotics can cure any bacterial infections emerging antibiotic resistance was usually overcome by treatment with new generation of antibiotics but during last decades bacteria are clearly winning this race overuse of antibiotics particularly in agriculture and lack of investments in discovery of new antibiotics lead us to situation when increasing number of bacterial infections cannot be cured due to lack of effective remedy antibiotic resistance surveillance revealed rising antibiotic resistance around the world who predicts that if no appropriate actions are taken by 2050 antibiotic resistance will be responsible even for 10 mln deaths every year to address this urgent medical need new antibiotics and alternative methods of combating antibiotic resistant bacteria are needed one of the new approaches which is getting more and more interests among academic and industrial research groups are enzybiotics bacteriolytic enzymes that in a very effective and selective way eliminate bacteria including antibiotic resistant strains at the same time displaying very low resistance prevalence enzybiotx provides a deeptech platform for tailor madeenzybiotics targeting specific bacteria our company has developed the platform for design and generation of new enzybiotcs to target pathogenic bacteria of interest as an answer to the need of alternative antimicrobials development the company in collaboration with potential clients is able to prepare tailormade enzybiotics which target pathogens and in collaboration with the client perform all tests needed to adjust enzymes properties to be able to introduce them to the final products the founders of the company are experienced academics who have gathered unique expertise in isolation and characterisation of new enzybiotics
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machinery rooms of the mediterranean 1800present images and visual archives of movement and acceleration
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the aim of medmach is to write a new history of the mediterranean after 1800 through images of movement infrastructures and machineries of acceleration such as airports train stations motorway bridges industrial ports and enginedriven ships these sites are often overlooked in overarching narratives of the region the mediterranean after 1800 typically appears either in decline or romanticized therefore this machinery room of modernity has never been at the center of attention however these sites of movement are connected to all the aspects which make the mediterranean an emotive politically relevant place today migration colonization and decolonization the relation between europe and the islamic world environmental and economic crisis conceptualizing the modern and contemporary mediterranean through its machinery rooms of movement will slice through the divisions of fragmented national histories and provide a basis for the differentiated yet connective history that is needed to face those challenges this history will be based on images and image archives in the modern period after 1800 images are increasingly made for distribution and circulation they are entangled with the ambivalent modern notions of movement and acceleration they are also ideal carriers of transnational and transregional knowledge medmach will advance epistemic knowledge about the modern and contemporary mediterranean moreover it will work with a visual approach to establish a new systemic historical understanding which is urgently needed in current debates on travel transit migration environment and cultural encounter key words mediterranean visual archives infrastructure mobility acceleration migration modernity circulation
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polarized 3d endoscopy
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the proliferation of artificial intelligence ai has led to a major advancement in many fields it has enabled achieving nonprecedent achievements such as humanlevel image recognition intelligible language translation and accurate medical diagnosis the main research goal of the pis ercstg spade project is to use tools for data modelling to improve our understanding and usage of deep learning dl and thus enhance its performance in medical problems and computational imaging 14 one of the fields that could greatly benefit from such progress is sensitive medical treatment using aibased medical devices such devices can initially assist the physicians with a more accurate diagnosis and potentially save lives as such technology matures the information provided to the physicians will be richer thus leading to more accurate diagnoses to the cases at hand such advancement will allow high quality and efficient treatment to a much wider public the scope of this poc is to apply intelligent optical imaging methods developed in the spade project specifically for introducing reliable 3d and polarization information to medical imaging devices
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how perceptual history shapes vision neural mechanisms and predictive properties
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what we see at any given time is not solely determined by the information currently reaching our eyes the visual system is indeed thought to leverage on perceptual history ie the stimuli saw in the recent past to contextualise and optimise perception the incorporation of past stimulus information into perceptual processing has important consequences shaping how we perceive external objects and events according to the context in which they are embedded in namely perceptual history can bias perception in an attractive way making a stimulus to appear more similar to its preceding one than it actually is the nature and mechanisms of attractive perceptual history effects are however unclear due in part to seemingly conflicting findings suggesting either that the bias is perceptual in nature occurring in lowlevel sensory areas or a cognitive effect based on decisionmaking with previs i will provide a new perspective on these effects proposing and testing a novel hypothesis namely instead of being uniquely based on past information as currently assumed attractive perceptual history biases may entail an active predictive mechanism in this scenario the attractive bias would arise from a prediction based on past stimuli rather than the past stimuli themselves performed by highlevel brain areas and affect the processing of sensory information in lowerlevel areas in previs i will use psychophysical techniques coupled with electroencephalography eeg and functional magnetic resonance imaging fmri to test this hypothesis and assess the neural signature and correlates of perceptual history and predictive processes the innovative perspective of previs represents an important step forward from the current state of the art and the project has the potential to clarify the nature of perceptual history effects and the mechanisms involved in this fundamental process shaping perception
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understanding emergent physical properties of chromatin using synthetic nuclei
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the main aim of this proposal is to resolve how the physics of molecularscale activities result in the emergent material properties of chromatin and how those contribute to chromatin organization and function mounting evidence suggests that the material properties of chromatin regulate essential nuclear processes chromatin has been studied with two disconnected approaches pure in vitro studies perfectly suited for careful biophysical measurements on single dna molecules but lacking the complexity of a cell or intact cell measurements with limited access to measure material properties and smallscale chromatin dynamics the physical properties of chromatin however are emergent and result from the molecular activities that are in turn regulated by those properties as a consequence it is crucial to establish new experimental assays that connect these two scales and levels of complexity here i will bridge the gap in scales and biochemistry between pure in vitro assays and measurements in intact cells by reconstituting chromatin processes in xenopus laevis egg extracts across scales i will combine quantitative microscopy optical tweezer measurements and theory to biophysically characterize the selforganization of proteindna cocondensation and loop extrusion and single chromatin molecules of increasing complexity to bridge the microscopic and the macroscopic scales i will assemble synthetic nuclei made of preengineered dna sequences which allows for exquisite control of dna length amount and chromatin activities in combination with microrheology micropipette aspiration and magnetic tweezers i will unravel how the collective behavior of chromatin activities gives rise to the emergence of largescale material properties of chromatin this project will provide a physical description of the material state of chromatin across scales and contribute to reveal the basic physical principles that govern nuclear organization and function
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perovskite ferroelectric materials for sustainable energy technologies
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many governments are working towards decarbonising their economies with the eu having set netzero targets to be reached by 2050 at the moment however still about 70 of all the worlds power comes from burning fossil fuels ie coal oil gas it is clear that in order for these goals to be feasible and economically viable the way we generate and use energy needs to change drastically one way of addressing this challenge is research into novel more advanced classes of quantum materials where broadly speaking new structural and electronic properties can start to emerge here ferroelectrics are a leading candidate for achieving highperformance energy technologies offset aims to explore the potential of ferroelectric materials for future energy applications by focusing on one specific material class nitride perovskites while the properties of many nitride perovskite candidates have already been studied computationally experimental realisations have been lacking hindering potential applications in order to achieve these goals offset aims to synthesise a number of structures using molecularbeam epitaxy this will be combined with advanced characterisation techniques including cryogenic and structural measurements as well as piezoresponse atomicforce and transmission electron microscopy in order to assess their quality and quantify the piezoelectric ferroelectric response at a later stage offset also aims to explore potential technological applications including uses as memories photovoltaics andor thermoelectrics this will be achieved via an advanced nanofabrication programme making use of the cleanroom facilities available at both project partners with these efforts offset expects to acquire fundamental knowledge on the viability and feasibility of nitride perovskites for use in future energy technologies
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dynamic navigation and port call optimisation in real time
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decarbonization of maritime transport through carbonfree fuel is a daunting and expensive process new propulsion systems such as windassisted will contribute to fuelsavings still whatever the pathway for a sustainable transition towards net zero emissions by 2050 more energyefficient operations remain a prerequisite this applies to the ship sailing as well as the port call processes efficient and viable voyage and port call optimization requires much increased cooperation between parties and overcoming several important barriers such as charter parties and contracts enabling just in time arrivals and more explicit riskbenefit sharing improved transparency and reduce cybersecurity risks reliable and efficient voyage and port call information sharing among all parties any new voyage optimization tool must take all these constraints into consideration and ensure full transparency on the arrival times to be agreed between the parties before the optimized route is activatedthe goal of dynaport is to develop new optimization and coordination tools for ports and ships that both reduce the ships fuel consumption and increases port efficiency with at least 10 kpis will be developed to quantify and measure these savings the tools will be built on information sharing through internationally accepted protocol standards and communication systems to improve port efficiency as well as port approach safety the system will integrate the port vts in arrival and departure planning and executionthis goal is fully aligned with the strategic research and innovation agenda for the partnership on zeroemission waterborne transport underlining the lack of standardized technologies and infrastructure enabling operational integration with ports as one key barrier to faster decarbonization of maritime transport but also with the imo strategy on the reduction of ghg emissions from ships and wider initiatives by the ec such as the european green deal
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metalorganic frameworks as concerted protonelectron transfer mediators for electrocatalysis
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as the consequences of the anthropogenic contamination become more evident and irreversible there is an increasingly urgent need to switch towards more sustainable paradigms in the chemical industry in this context the utilization of renewable energy sources via electrocatalysis has emerged as a highly active field of research during the past decades although further efforts are required to provide economically viable technologies with practical applications ecatmof project aims at developing efficient electrocatalysts for chemical reactions based on reductive protonation these processes are ubiquitous to a large number of industrially relevant transformations such as reduction of olefins carbon dioxide or dinitrogen an electrocatalytic approach will offer a sustainable alternative to harness renewably sourced electricity to power such transformations avoiding current harmful processes that pose important obstacles towards a circular economy the strategy of ecatmof project is based on accessing concerted protonelectron transfer cpet reactions due to their energetic benefits allowing operation at milder potentials and thus outcompeting the otherwise dominant hydrogen evolution reaction to this end ecatmof will target the design of novel cpet mediators based on an interdisciplinary approach incorporation of molecular redox and acidbase mediators in the structure of metalorganic frameworks mofs and the immobilization of the resulting materials on carbonbased electrodes this strategy merges the fields of molecular inorganicorganometallic chemistry reticular materials and heterogeneous electrocatalysis to overcome challenges associated to undesired bimolecular reactivity low current density limited faradaic efficiency difficult product separation and catalyst recovery the expected implications of ecatmof will have a broad impact in the progress towards the integration of renewable energy schemes into the chemical industry
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paving the way towards digitalisation enabling agroecology for european farming systems
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the potential of agroecological farming systems to master many of todays challenges to the environment economy health and society can be significantly promoted by coupling with digital tools and technologies path2dea is committed to unlocking digitalisations catalysing power to foster european agricultures transition towards enhanced sustainability it will build on farmers competences and views and match them with the rich repertoire of digital solutions already available for agriculture aimed at tailoring digital technologies to users needs and fostering widerange adoption of digital agroecological farming in the eu and associated countries strategic engagement by multiple actors includes early adopters of digital agroecological farming represented by six showcase farms located in different pedoclimatic regions with handson experience for solid consensus validation of the projects conclusions path2dea is deeply rooted in the european agroecology innovation ecosystem and will establish itself amidst key players and proven instruments to mediate and connect among disciplines and sectors with a clear ethicalsocietal perspective via interactive discussion rounds specific situations regarding digital technology uptake and use will be explored and brought to consideration by actors and stakeholders for increasing awareness and understanding path2dea will deliver a robust knowledge base in the frame of an open source repository of digital tools and technologies in agroecology with decision support functionalities and a wellaligned ri roadmap for guiding digital agroecology transition finally path2dea will use its results for bridging towards the upcoming european agroecology partnership
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largearea perovskite solar module manufacturing with high efficiency longterm stability and low environmental impact
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in recent years organometal halide perovskitebased photovoltaics pv have attracted great interest for their high power conversion efficiency at low manufacturing cost presently east asia especially china and north america are rapidly ramping up towards mass production of perovskite pv more efforts are urgently needed for perovskite pv upscaling in europe laperitivo focuses on the development of largearea stable perovskite solar modules using processes with high manufacturability efficiency targets are 22 and 20 for 900 cm2 opaque and semitransparent with 95 bifaciality modules respectively key research activities include the deposition of highquality perovskite films as well as contacting layers over large substrate area using industrially viable techniques indoor and outdoor field tests in line with international electrotechnical commission iec standards will be performed to monitor module reliability safety circularity and sustainability will be assessed to demonstrate products with minimized environmental impact the developed semitransparent modules will be applied to perovskitesilicon fourterminal tandem modules and also to agrivoltaics design of perovskite pv pilot line of 200 mw and production capacity of 5 gw in europe will also be explored the wellbalanced consortium consists of 22 complementary partners including 8 european leading research institutesuniversities imec unitov empa fraunhofer ise ipvf cnrs csem hellenic mediterranean university 1 african research institute green energy park morocco 5 small and mediumsized enterprises becquerel institute becquerel institute france becquerel institute spain dyenamo tse troller smartgreenscans bedimensional and 6 big companies pilkington technology management limited ptml singulus technologies voltec solar engie totalenergies edf in this way the project aims to establish the pathway to open the era of manufacturing perovskitebased nextgeneration pv products in europe
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textilebased metamaterials for broadband noise absorption in lowfrequency range
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owing to rapid urbanization millions of people are suffering noise especially the noise in a lowfrequency regime 500 hz conventional acoustic absorbers eg glass fiber and polyester fiber have been applied to control the noise by absorbing incident acoustic energy while the sound absorption in the lowfrequency regime using such absorbers is impractical because their dimensions are usually comparable to the large wavelengths of lowfrequency sound waves in recent years acoustic metamaterials have exhibited excellent lowfrequency sound absorption performance however these metamaterials usually produce only one narrowband absorption peak furthermore the practical application of most of the acoustic metamaterials is hindered due to the highcost manufacturing techniques ie 3d printing and low production efficiency this project proposes a new classification of metamaterials which is composed of textiles the textile manufacturing techniques are highly efficient textile fabrics can form different resonant elements eg cavity structure gradient index structure and membrane structure employing textile technologies and manifold assemblies moreover the different textile resonant elements can combine together to fabricate integrated broadband lowfrequency sound absorbers the knowledge and technologies from acoustic and textile disciplines will be integrated to achieve the aim one of the most important aims of this project is to develop the metamaterials made by textiles to overcome the shortcomings of currently known metamaterials this project provides a new possibility to solve the noise problem to increase life quality of the public another essential objective is to acquire new knowledge and skills from the host to improve the career competencies and professional experience of the applicant this objective and sharing the skills with the host will be fulfilled through twoway transfer approaches eg training presentations etc
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materialsgrowl gauging the restofworlds lifecycles of construction materials
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this project materialsgrowl will assess the current and future construction material uses that compose human settlements of the global south which is sometimes indiscreetly aggregated as the rest of the world row in global studies this is crucial because construction materials have global environmental impacts half of yearly consumption of all raw materials significant shares of carbon emissions and major contributors to land use change most of their future demands and thus environmental and societal impacts will occur in the global south this is also challenging because understanding the lifecycles of construction materials how many and which materials where are they used to what ends and with which impacts has been daunting due to limited data and research frameworks the global south has been neglected so far and the little understanding we have is incomplete uncertain and incoherent thus the environmental and socioeconomic risks related to construction material use in the row countries now and in upcoming decades are only generically studied or remain unknownmaterialsgrowl will 1 develop novel methodologies to produce highresolution construction material data in the global south and link these to the societal services and human needs they provide 2 compare future material use developments to 2070 under a suite of different socioeconomic and wellbeing pathways 3 identify environmental and socioeconomic risks imposed on and by construction material accumulation and 4 form an exchange framework for crosstransfer of material use knowledge materialsgrowl will overcome the severe data and methodological challenges that held back the study of construction material use in the global south it will provide data and methods crucial for addressing the sdgs and material prerequisites of decent living standards the results will link the development of the built environment with its impacts to inform further research policy and action
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innovative alkaline earth systems for the activation and functionalization of dinitrogen and other challenging substrates
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catalysis is a powerful tool to address profound challenges in europes energy transition however many current catalytic systems face important limitations in relation to activity selectivity or cost efficiency particularly the production of ammonia relies upon the centuryold energyintensive haberbosch process which is estimated that consumes up to 3 of the global energy produced every year this eufunded aefun project will develop innovative systems based on earthabundant readily available alkaline earth metals for the challenging conversion of dinitrogen into ammonia and other nitrogencontaining valuable chemicals this will be achieved by harnessing the unexplored modes of cooperativity between transition metals and lowvalent alkaline earth elements we envision that unusual participation of d the orbitals from the ae element and the redox activity of transition metals will give place to unseen synergies that will facilitate the activation of highly challenging substrates n2 co2 co h2 and their functionalization
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dimensional insights into dissipative kerr solitons
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the enlightens project focuses on investigating how dimensions influence the dynamics stability and characteristics of dissipative solitons ds within externally driven multimode kerr cavities ds are fascinating localized structures that maintain their inherent shapes during propagation owing to a delicate balance between the nonlinear kerr effect linear dispersiondiffraction gain and dissipative processes these states retain their temporal profiles along the propagation direction forming temporal solitons or preserve spatial profiles orthogonal to the propagation direction leading to the emergence of spatial solitons spatiotemporal solitons stds represent a class of states that not only maintain spatial but also temporal profiles exhibiting complex dynamics however such states tend to be vulnerable to wave collapse in this context the enlightens project seeks to explore the dimensional aspects affecting the stability of ds as dimensions increase and develop strategies to enhance their stability my preliminary findings suggest that phase modulation has the potential to expand the stability range within 1d temporal ds and could potentially stabilize 3d stds within this framework i will further conduct a comprehensive bifurcation analysis of these 1d temporal dissipative states under various influences laying the groundwork for further investigation subsequently i will focus on the transition of these 1d states by introducing spatial effects as a weak perturbation that later becomes a dominant factor in the system this methodology enables me to progressively tackle increasing complexity facilitating the study of highdimensional problems in a stepbystep fashion understanding these states holds paramount significance and carries the potential for groundbreaking advancements across diverse technological domains including the development of innovative multidimensional kerr frequency combs
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excelling humancentric collaborative ecosystems for smart digital transformations in ccis
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excentric excelling humancentric collaborative ecosystems for smart digital transition in ccsi supports the digital transition aimed at sustainable and responsible growth in the european cultural and creative sectors and industries ccsi it addresses underutilization of data in the daily operations of specific experience sectors live music festivals theatre and museums these sectors are distinguished by their capacity to create value by providing audiencecentric intangible cultural experiences excentric develops and implements a collaborative data practice through the execution of four sectorspecific and two crosssectoral pilots under real working conditions by codesigning testing and equipping organizations within experience sectors with operationscentric smart data infrastructure and tools we can effectively integrate datadriven innovations into their strategic operations in programming pricing resource management and audience engagement the project applies humancentric principles by actively involving the creative workforces needs skills and interests of pilot organizations and their extended network in the tools development processes it builds organizational capabilities data literacy and skill sets to enable the adoption diffusion and customization of digital tools and supports sustainable innovation beyond the projects duration at the policy level excentric will formulate evidencebased recommendations for successful digital transformation by employing innovative practices and identifying relevant metrics based on pilot results the projects unique approach pioneers the concept of collaborative data practices in the ccsi which has proven effectiveness in pharma energy and logistics it aims to break down silos within the ccsi and foster ecosystem thinking excentrics exceptional consortium with six pilots across six countries and three paneuropean umbrella organizations broadens its impact and fosters adoption
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checmating cellular senescence by modulating the surrounding matrisome
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the increasing elderly population poses a dual challenge to the viability of both global health and our current welfare systems one of the pivotal aspects of aging involves the accumulation of damaged cells known as senescent cells in organs while these cells play a role in coordinating tissue repair whenever damage occurs their aberrant accumulation disturbs normal tissue function resulting in an unbearable burden that ultimately leads to aging understanding how these cells accumulate within the organism a yet unresolved question would offer invaluable insights into the aging process we have recently reported that damaged cells rely on integrins a family of membrane proteins to implement senescence over cell death leading to their accumulation within injured tissues remarkably integrins are known as the major cellular receptors binding to the surrounding extracellular matrix ecm considering these precedents we aim to take a step further and investigate whether the composition and status of the ecm can influence the buildup of senescent cells by impacting the choice between senescence and cell death upon injury a possibility not explored before here we aim to assess whether certain ecm proteins might act as prosenescence factors by desensitizing damaged cells to death favoring survival and aberrant senescence instead we will thoroughly characterize multiple cell culture and mouse models of senescence implementation following damage aiming to unveil the mechanisms controlling this phenomenon leveraging these findings we will modulate the occurrence of cell senescence through ecm reengineering in mice seeking to establish a revolutionary approach to address aging and tissue fibrosis in sum by uncovering unsuspected links between the ecm status and cell senescence implementation checmate senescence would signify a paradigm change that would enable an unprecedented strategy in targeting cellular senescence in detrimental scenarios
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breath pathogen detection bpath establishing exhaled breath aerosol xba sampling for diagnosis and screening of respiratory infections
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respiratory infections resulted in 7 million deaths in 2020 and were responsible for 7 of the last 9 pandemics causing trillions of s in economic losses despite the importance of early detection for individual health and pandemic control flawed sampling methods for respiratory infections limit the impact of highlysensitive diagnostics the bpath project will tackle this problem by establishing exhaled breath aerosol xba as an evidencebased noninvasive sample for simple detection of respiratory infections that can be undertaken at all levels of care we will achieve this by developing and optimising two innovative easytouse and scalable xba sampling devices and generating evidence for their use in diagnosis and screening for early diagnosis and transmission control we will use different model pathogens that have caused epidemics and pandemics globally sarscov2 influenza and tuberculosis tb and we will generate data on the feasibility of multiplex detection of respiratory pathogens in xba samples the adaptability to novel pathogens applying viral metagenomics and pointofcare testing with lateralflow assays we will assess the sampling efficiency of the novel devices against a benchmark respiratory aerosol sampling chamber and evaluate performance feasibility and acceptability in comparison to the current standard of sampling in multicountry clinical studies of diagnosis and screening impact and economic modelling will inform the implementation potential of the novel devices for the different use cases and help assess tradeoffs the project will leverage innovation in bioaerosol and material science as well as the multidisciplinary including academia industry and ngos consortiums track record of delivering transformative diagnostic innovation we envision that a single breath sample enables accessible and accurate detection of highly transmissible respiratory infections thereby improving both individual and population health
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hopes and futures of academia reimagining bacons new atlantis
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atlantis tackles the multifaceted challenges facing academia today by focusing on alternatives articulated within or at the boundaries of higher education these challenges are not only practical but also deeply theoretical and engage fundamental epistemological and ontological discussions about the intertwinedness of science and society and the knowledge this relation generates using francis bacons new atlantis 1626 as a reference point this projects ambition is to cocreate different narratives infrastructures and frameworks that amend the consequences of the technocratic imaginaries of knowledge and progress crystallised in this story following the lead of researchers that have taken peoples hopes and visions as objects of analysis and entry points into broader societal concerns atlantis aims to 1 develop a nuanced account of the diverse challenges facing academia and better understand emergent or successful responses and transformation and 2 cocreate possible and utopian academic worlds that open new horizons for meaningful discussions and paradigmshifting actions that account for its current weaknesses and blind spots particularly when it comes to gender and multispecies entanglements atlantis is anchored in anthropology and science and technology studies sts and focuses on three distinct but interconnected lines of inquiry about academia and its future at the present neoliberal moment atlantis takes a forwardlooking approach that is historically and ethnographically grounded while engaging innovative cocreation and futureoriented techniques articulated at the intersection of anthropology innovation and design atlantis is hosted at the norwegian university of science and technology ntnu and includes a secondment at the university of california los angeles ucla it is cosupervised by vivian anette lagesen knut h srensen and sharon traweek
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interactive tools for the study and the enhancement of music iconography
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while music is undoubtedly a primary expression of any civilization western society seems to have moved further and further away from the music of its past thus missing a great wealth of its own identity rethinking how we approach historical music is essential to bridge this gap and inmusic intends to make an innovative contribution in this direction the project will focus on a particularly interesting yet littleaddressed branch of cultural heritage music iconography addressing it through a multidisciplinary approach that combines iconological methodology with the application of digital technologiesdue to the very nature of music iconography digital technologies represent a tool with enormous potential for both its study and enhancement in fact only in a virtual context is it possible to reconstruct the original ideal multisensory nature of musical images while digital means allow the socialization of highly specialized musicrelated contents in a dynamic and engaging way nonetheless little has been done to fully explore this potential especially in terms of interactivity inmusic will address early modern spain music iconography and will delve into different digital approaches and communication strategies in order to devise replicable and versatile instruments a semantic database based on cidoccrm and a set of prototypes of digital devices will be elaborated resorting to the use of different opensource software all the prototypes will be submitted to different targets of public who will be asked to fill out a specifically designed survey to collect useful data for the evaluation of the effectiveness of such tools in communicating knowledgethe success of the action will therefore increase our knowledge on spanish musical imaginary in a crucial historic context while providing scholars and cultural stakeholders with efficient means to study teaching and enhance an unconventional heritage
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control of rna polymerase ii and transcription factors via idrs
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rna polymerase ii pol ii plays a pivotal role in human cellular function carrying out the complex transcription process a unique domain sits at the end of pol ii the cterminal domain ctd the phosphorylation of which offers a mechanism of interaction for transcription factors tfs that regulate the transcription process the spatial organization of tfs around pol ii is moderated by the intrinsically disordered regions idrs of the tfs and ctd and high specificity is required to avoid disease causing defects however the exact mechanisms that maintain this environment and their importance are still unknown here we suggest a method for determining crucial pol ii tf interactions by relating electromagnetic imaging to computer simulations results will be able to delineate individual amino acids responsible for maintaining the spatial organization of the proteins in vitro the simulationbased study will be leveraged to explore the tolerance of maintaining these interactions when encountered with different phosphorylation states of ctd a proofofconcept study is then described which will demonstrate an ability to actively target idrs to stabilize the protein interactions while the results here will be comprehensive for four tfs of interest recql5 scaf4 scaf8 and the soss1 complex the methodology can then be expanded to characterize a library of over 400 tfs such a project has the potential to not only further our understanding of ctds function but also pave a way for designing synthetic treatments that can regulate the transcription process
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novel boronbased two dimensional materials as heterogeneous catalysts
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the proposal 2dborocat addresses synthesis characterization and catalytic applications of borophene new wonder material thathas attracted extensive attention from the scientific community due to its intriguing properties despite the attractive properties ofborophene lack of facile lowcost and efficient production method restricted its industrial applications therefore major focus have been given in developing a synthetic route to borophene that outclasses the limitations of existing methods and modifies the present stateoftheart synthesis further its use as catalyst in various industrially relevant transformations is suggested for the first time especiallythe proposal addresses one of the defining environmental energy and societal challenges of 21st century the conversion of co2 tovalue added chemicals especially lpg both thermal as well as plasma reactors will be used to accomplish the target of co2 reduction plasma catalysis has the distinct advantage that the conversion can be achieved at a lower temperature and pressure compared to pure thermal catalysis the proposal is highly novel and timely in the present context of global warming due to increasing anthropogenic co2 emissions and diminishing fossil fuel reserves in addition to this other important reactions such as oxidative dehydrogenation odh and ammoniaborane hydrolysis etc will also be investigated 2dborocat is expected to create huge scientific economical and societal impact in terms of co2 mitigation strategies
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bringing eusolaris eric to its zenith
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the solarize project intends to enhance the longterm sustainability of the eusolaris eric by successfully achieving its general objectives enlargement of the membership further involvement of rd institutes and national funding institutions at the national nodes educating new researchers to make appropriate use of the ris reinforcement of international cooperation and of science diplomac improvement of the managerial skills of its staff strengthen the interaction between industrial stakeholders and cst researchers increase of the general awareness of other possible applications of cst ris eg industrial process heat development of new standards and testing protocols creation of the first einfrastructure providing remotevirtual access to the rd centres study of best ways to combine cst with other energy sources and last but not least targeting the greening of technologies and methodologies used by the cst ris
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metal matrix nanocomposite coatings utilization as alternative to hard chromium
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the mozart project proposes sustainable coating solutions for replacement of hard chromium in specific applications based on nanocomposite electroplating processes nanocomposite coatings are potential candidates as durable protective coatings in applications where high wear and corrosion resistance is needed their significant advantage compared to other alternative solutions to hc is that they can be produced from the existing infrastructure of plating shops by applying lowcost modification in the lines for the safe integration of nanoparticles keeping thus the investment level low the mozart project proposes a multidisciplinary approach for achieving high quality durable composite coatings as replacement to hard chromium the proposed technologies have been already validated in the lab scale trl 3 on previous ec national or institutional projects and will reach trl 5 by the end of the project validated in pilot scale and real demonstrators the proper integration and combination of these technologies will bring the nanocomposite coatings to the desired technology maturity more specifically during the mozart project a combination of technologies will be used under a safe sustainable by desing strategy insilico method artificial intelligence and simulations online monitoring technologie chemical functionalization of nanoparticles and advance electroplating techniques the novel nanocomposite coatings will be tested in demonstrators introduced from companies smes or les in the field of manufacturing automotive and machinery
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marine munition in europe solutions with economic and ecological profits for efficient remediation
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the mminesweeper project will advance knowledge capability and capacity in europe for dealing with marine munition in the nonmilitary aspect of uxoclearance 21 partners from 7 eu and 2 associated countries bring experience and capabilities from the civil science community 9 military research 3 coastborder guards or eodservices 4 as well as industry 3 and intergovernmental organizations 2 jointly they will work in 8 technical work packages to a advance automated munition detection identification and data analyzing technologies and software b environmental monitoring of chemical contaminants c predictions of uxoburial contaminants spread and the stateofcorrosion and will d enable secure exchange of sensitive data 64 of person months three additional wps will compile existing knowledge learn about the legal responsibilities and technical approaches assess remediation and mitigation measures and create training material for building european capacity 14 pm two wps will engage in an intense stakeholder dialog and disseminationoutreach activities by utilizing capacities already existing at helcom and jpio 14 pmoutcomes with respect to specific technical advancements will include a aisupported detection of munition in hydroacoustic spatial mapping data mbes sss sas b detection of buried munition objects magnetic sbp lfsas c aisupported object identification in optical and acoustic cameras and d implementing trained aimodels into smartauvs and usvs for adaptive and cooperative mission execution all this will utilize secure data exchange possibilities through a demonstrator data platform that will be refined during the project industry partners see a great benefit in developing technologies that later can be advanced further to become commercial products at the end of the project most trls will be at 5 to 6 meaning they have been applied under real conditions and proved their applicability
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simulationenhanced highdensity magnetomyographic quantum sensor systems for decoding neuromuscular control during motion
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being able to decode neural signals that control skeletal muscles with high accuracy will enable scientific breakthroughs in diagnostics and treatment including early detection of neurodegenerative diseases optimising personalised treatment or gene therapy and assistive technologies like neuroprostheses this breakthrough will require technology that is able to record signals from skeletal muscles in sufficient detail to allow the morphofunctional state of the neuromuscular system to be extracted no existing technology can do this measuring the magnetic field induced by the flow of electrical charges in skeletal muscles known as magnetomyography mmg is expected to be the gamechanging technology because magnetic fields are not attenuated by biological tissue however the extremely small magnetic fields involved require extremely sensitive magnetometers the only promising option is novel quantum sensors such as optically pumped magnetometers opms because they are small modular and can operate outside of specialised rooms our vision is to use this technology and our expertise in computational neuromechanics to decode for the first time neuromuscular control of skeletal muscles based on in vivo highdensity mmg data for this purpose we will design the first highdensity mmg prototypes with up to 96 opms and develop custom calibration techniques we will record magnetic fields induced by contracting skeletal muscles at the highest resolution ever measured such data combined with the advanced computational musculoskeletal system models will allow us to derive robust and reliable source localisation and separation algorithms this will provide us with unique input for subjectspecific neuromuscular models we will demonstrate the superiority of the data over existing techniques with two applications signs of ageing and neuromuscular disorders and show that it is possible to transfer these methodologies to clinical applications
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web3 platform for formal mathematics
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mathematics is today on the verge of a revolution formal computerverified proofs become ubiquitous and largely adopted as the new means of communication and collaboration this led to landmark proofs such as haless verification of the kepler conjecture and scholzes condensed mathematics recently validated by computers generating considerable momentum in the mathematical community simultaneously there is growing industrial demand for formal proofs of software and hardware similarly web3 constitutes a transformation of how data and collaboration are realized in a decentralized intelligent and interconnected wayin this project we will develop a web3 platform for formal proofs designed to establish connections between mathematicians researchers in formalization communities and businesses this platform will also integrate stateoftheart verification ai and autoformalization tools to assist in the creation of computerunderstandable proofs the proposed work will include the development of a wiki for formal mathematics with integrated blockchainbased tokens that reward users for their contributions we will provide translations for various logics and proof systems and investigate the safety and security of the protocols on the business side we will conduct market research engage potential customers clarify intellectual property rights and formulate licensing solutionsthe project builds on the success of our erc project smart where we have already developed software that harnesses artificial intelligence for advanced logical reasoning and proposed novel approaches to decentralizing proof verification using blockchain technology in the current proof of concept project we aspire to expand these software capabilities into a holistic web3 platform that will serve as a collaborative hub enabling diverse stakeholders to collaboratively address practical verification and formalization challenges while rewarding users for their contributions
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targeting mechanisms of thromboinflammation
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the recent covid19 pandemic dramatically illustrated i the clinical relevance of thromboinflammation the interplay of coagulation and inflammation and ii our limited understanding of molecular mechanisms of thromboinflammation thromboinflammation is a frequent diseasedriving mechanism impairing outcome of viral or bacterial infection cardiovascular disease cancer and other diseases the lack of mechanistic insights hampered the development of specific therapies my group recently discovered a new molecular link between coagulation and inflammation that addresses this enormous unmet medical need the initiator of coagulation tissue factor tf f3 cd142 forms a previously unknown heterodimer with the cytokine receptor ifnar1 interferonalphabeta receptor alpha chain on resting cells in this heterodimer tf and ifnar1 are both inactive upon stimulation eg fviifviia lps polyic the heterodimer dissociates activating tfmediated coagulation ifnar1mediated inflammation and cellular metabolism this provides a novel yet simple molecular switch simultaneously controlling coagulation inflammation and metabolism this switch is expected to provide a new conceptional framework for thromboinflammatory diseases to enable future translation of this novel mechanism i aim to address the following open questions i how is this molecular switch regulated in an organ and context specific fashion in vitro work cellspecific inducible tfifnar1 deficient mice ii what are the consequences of this molecular switch for intracellular signaling inflammation mitochondrial metabolism omics with bioinformatic analyses and iii what are the molecular structures required for the tfifnar1 interaction crosslinking crystallography phage display computational modeling i expect that answering these questions will lead to new diagnostic and therapeutic approaches revolutionizing the way we detect and treat thromboinflammatory diseases
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uncovering the inner workings of galaxies at cosmic noon
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lookback studies have assembled a fairly complete census of galaxies over 85 of cosmic time and established that the bulk of stars which today reside in massive ellipticals and spirals formed rapidly at redshift z13 most of this star formation took place in massive gasrich turbulent disks which already followed tight scaling relations in their global properties and in which dense bulges fast growing central black holes and galactic winds were ubiquitous the next frontier is to uncover the physical mechanisms inside galaxies that govern the buildup of stars and the emergence of galactic structure this goal can only be reached by resolving gas motions and distributions on the toomre scale of 1 kpc at z1 requiring 25 times sharper views than typically achieved so far revolutionary improvements in observing sensitivity and resolution now make this possible the advent in 2022 of the most advanced nearir adaptive opticsassisted integral field spectrograph eris at the very large telescope galphys centers on an ambitious 900hour eris guaranteed time program led by the applicant and exploits key synergies with cuttingedge submillimeter interferometry at iramnoema and alma of which the applicant is a core member of guaranteed and open time programs the requested 3 postdoc and 2 phd positions are required for the pi to establish a research group to execute the program galphys will produce breakthroughs in the most important outstanding issues in galaxy evolution 1 mass and angular momentum transport 2 the origin of gas turbulence 3 the evolution of giant starforming complexes and 4 the physics of outflows powered by stellar and agn feedback galphys will provide excellent training for junior scientists and an unmatched benchmark of lasting legacy in galaxy evolution
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development of novel integrated sequencing methods to explore translation and its regulatory mechanisms in single cells
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in recent years novel singlecell sequencing methods have allowed an indepth analysis of the diversity of cell types and states in a wide range of organisms due to the continuous optimization of experimental and computational methods by many research groups it is now possible to sequence the transcriptomes of thousands to millions of individual cells albeit an exciting development transcription only covers the first step in the central dogma the second step the process of translation is currently much harder to explore in single cells building upon existing ribosome profiling protocols our laboratory recently majorly increased the sensitivity of these assays allowing ribosome profiling in single cells however currently no methods exist to determine the translation efficiencies in single cells and to correlate translation efficiencies to trna levels and their modifications rna bound proteins and m6a methylation of mrna all major regulatory mechanisms of translation the overarching goal of this proposal is to develop several novel multiomics approaches to quantify translation in single cells by integrating information on ribosome position along the transcript trna expression levels trna modifications rnabound proteins and the m6a methylation status of the transcript these technologies will open novel avenues to start exploring translation and its regulatory mechanisms with singlecell resolution whereas major discoveries have been made during the last decade by exploring the genome the epigenome and the transcriptome using singlecell sequencing approaches translation the major second step in the central dogma is still very much unexplored at the singlecell level i hope that the tools presented in this proposal will provide the community with methods to explore and ultimately understand how translation contributes to the astonishing heterogeneity among single cells
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identification of best practices for biodiversity recovery and public health interventions to prevent future epidemics and pandemics
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epidemics and pandemics most of them caused by zoonotic and vectorborne emerging diseases are globally threatening our health and welfare at an alarming pace prevention of future disease outbreaks will be pivotal to secure human welfare and demands transformative change biodiversityisgoodforourhealth has become a new paradigm in disease risk mitigation consequently nature restoration targeting biodiversity recovery isolated or in combination with public health interventions has been identified as a major disease risk mitigation tool while there are thousands of ongoing and planned nature restoration projects globally we lack knowledge a if such restorations indeed interrupt the infectshedspillspread cascade and mitigate disease risk b or if they rather amplify the risk and c on success factors characterizing restorations that mitigate disease risk beprep will fill this lack in knowledge and provide practical guidance in spatially and temporally replicated field studies and experiments in case studies in europe and the tropics we will study ac and reveal the causal mechanisms of infection dynamics and of drivers along the infectshedspillspread cascade bepreps participatory and transsectorial approach by actively involving indigenous and local communities will enable the identification of success factors of best practice restorations and interventions incl naturebased solutions to guide future biodiversity recovery measures that promote healthy ecosystems these success factors will contribute to a interrupt the infectshedspillspread cascade and b ultimately prevent disease outbreaks the results of beprep help to create a european society prepared and responsive to disease risk beprep will hence accelerate the ecological transition required to meet eus biodiversity strategy for 2030 as a core part of eus green deal and support a green recovery following the covid19 pandemic
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circadian control of systemic metabolism in physiology and type 2 diabetes
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type 2 diabetes is a global epidemic with prevalence of 500 million the current obesogenic environment favoring high caloric foods and physical inactivity is a major driver of this epidemic an evolutionarily conserved mechanism by which environmental factors impact whole body physiology is through internal biological clocks and the control of circadian rhythms this machinery is a transcriptiontranslation feedback loop that anticipates daynight cycles to optimize organismal physiology however the underlying mechanisms regulating metabolic rhythmicity and its role in type 2 diabetes pathogenesis remain enigmatic cellular energy sensors relay information about the environment to the circadian clock machinery but the extent to which this biology can be modified to improve systemic metabolism is unknown we will uncover mechanisms that underpin the relationship between the circadian clock energy sensors and metabolism and their dysfunction in type 2 diabetes our overarching hypothesis is that synchronizing energetic stressors to the molecular circadian clock may maximize the health benefits on metabolism we will elucidate the mechanism by which the timing of energetic stressors acts on peripheral tissues controlling energy homeostasis we will study temporal dynamics of cell and organ physiology rather than snapshots in time we will integrate omics analyses with rigorous physiological phenotyping of genetically modified mouse models and clinical investigations in people with type 2 diabetes to temporally resolve dynamic networks of transcription protein signaling and metabolites which synchronously control metabolism in doing so we will come closer to understanding the dynamic changes that occur with metabolic dysfunction the work has the potential to make a breakthrough in clarifying underlying mechanisms for molecular regulation of metabolic rhythmicity how this is perturbed in type 2 diabetes and ultimately insight into new treatments
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towards an integrated consistent european lulucf monitoring and policy pathway assessment framework
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precise information on the current status of forests is required to forecast forest management effects which allows informed policy decisions to inform and support the implementation of these policy objectives pathfinder will develop and demonstrate an innovative integrated forest monitoring and pathway assessment system this system for the first time will allow a consistent eu greenhouse gas reporting of the lulucf sector but at the same time combine such monitoring capability with advanced pathway assessment to help plan the essential policy and implementation steps towards achieving the policy targets the continuous monitoring of forests facilitates controlling of target achievement and possibly adjustment of pathwayspathfinder goes beyond the stateofart by the most efficient combined use of field and remotely sensed data for highresolution mapping and precisely estimating forest attributes the cooperation of the largest forest monitoring organizations operating in the eu ie national forest inventories nfis and the network installed under icp forests provides a rich data base of harmonized ground truth information which will be complemented by an innovative field survey of consistently assessed field monitoring sites advanced measurement devices will provide an audiovisual digital twin including genetic properties of the consistently monitored forest for maximum transparency and interoperability of new data the analysis of combined databases will improve our understanding of fluxes among c poolsthe precise forest information of the monitoring system will feed into a new scenario framework that forecasts future forest scenarios and outcomes of forest management alternatives the scenarios facilitate tradeoff analysis of forest es and are potential alleys in the pathway assessment the pathway assessment is a cocreation activity in which novel monitoring and scenario studies are integrated with eulevel stakeholder visions and knowledge
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new era towards a responsible knowledge driven society of the 3rd millenium
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the objective of the project era conference is to create a space for stakeholders to engage with the formation of the new revitalised european research area era in order to pursue the european commissions goals of codesigning cocreating and codeveloping era policies with all era actors this delivers against the european commission communication from september 2020 on a new era for research and innovation and the council conclusions from december 2020 on the new european research areathe first day of the era conference focuses on the commissions proposal for a council recommendation on a pact for research and innovation in europe and the new era governance structure the second day will focus on implementation challenges with stakeholdersthe expected impacts of the era conference are a contributing to the commissions cocreation of era actions derived from the era policy agenda ensuring they are designed appropriately and b engaging stakeholders by giving them their own space to discuss the implementation of several actions the overall rationale of the era conference is based on the high level discussion on the topic of the renewal of the era and strengthening relations between stakeholders and the commission through workshop activities on the second day of the conference the era conference will also deliver promotional activities prior to the conference with stakeholder engagement through video testimonials on the topic of the renewal of the era which will be publicised alongside the conference additionally after the conference the publication of conference recommendations will contribute to the balanced development of the new era and could be used in further ministerial discussions on the renewal of era in the time of proposal writing it is planned for the conference to be held live however we also have a support plan in case we would have to switch to online event due to the pandemics
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stochastic interacting systems limiting behavior evaluation regularity and applications
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this se aims at addressing a number of challenging mathematical problems related to stochastic interacting systems with particular emphasis on the regularity properties of the solutions their limiting behaviour and numerical computation the equations we analyse arise from the modelisation of realworld phenomena in several fields of application including spiking neural systems hydrodynamics and financialenergy markets and share nonlinearity as a common underlying trait critically nonlinearity intertwines with other relevant features that include low regularity of the coefficients noise degeneracy jumpdiffusion dynamics and highdimensionalitythe study of stochastic interacting systems is highly multidisciplinary from a twofold perspective on one hand they have become a widespread modelling tool in a variety of applications for example they are used to model human neuron interfaces particle systems but also interacting agents in economics and finance in relation to managing risk and decentralised production of renewable energy on the other hand the set of mathematical and computational tools needed to reach a holistic understanding of stochastic systems is very vast ranging from stochastic partial differential equations random measures rough paths gradient flows in metric measure spaces numerical probability and computer simulationwe provide a team of experts that analyse stochastic systems integrating several approaches and techniques the complementary expertise across the network together with the consolidated experience and excellence of the key participants in their research areas places our network in the privileged position to make relevant contributions across interconnected research fields and to contribute to the training of the early career researchers involved in the project in an exciting field of pure and applied mathematics with the possibility of boosting their careers in both academic and nonacademic sectors
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novel advanced and repurposed therapeutics for vision restoration in a group of severe rare ocular surface diseases from validation to first clinical investigations
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rare eye diseases reds are a major cause of visual impairment and blindness in europe affecting patients of all ages the restore vision consortium identified a group of 7 reds all affecting the cornea and ocular surface that cause severe vision impairment and blindness and have inadequate treatment options today onset and progression is characterised by overlapping common pathophysiologic mechanisms defective corneal wound healing nerve degeneration stemcell dysfunction and aberrant vessel ingrowth the 7 reds targeted are aniridiaassociated keratopathy neurotrophic keratopathy limbal stem cell deficiency ocular cicatricial pemphigoid eec syndrome ocular graft versus host disease and corneal neovascularisation affecting over 500k patients in europecurrent management is often prohibitively expensive has low efficacy and leads to debilitating side effects pointing to a critical medical problem and area of unmet medical need restore vision brings together actors from across the full value chain 6 leading research institutions 3 smes and a european patient organisation we take a groundbreaking approach to improve eye health by verifying disease pathomechanisms using cuttingedge models for each rare disease to test novel and repurposed compounds and determine drug mechanisms of action formulating compounds as safe eye drop suspensions or subconjunctival drugs and performing several firstinhuman trials of novel therapiesnew therapeutics with gamechanging potential will be evaluated for the first time our pioneering streams approach is based on the repurposing of 6 existing drugs and the development of 3 new compounds all with solid preliminary data showing remarkable effects in restoring the cell physiology immune avascular neural and signalling environment in the cornea this innovative approach shortcircuits lengthy and complex regulatory and drug development processes ensuring rapid translation into the clinic
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nuclear observations to improve climate research and ghg emission estimates
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radon is an unique atmospheric tracer and highquality measurements of direct atmospheric radon concentration complemented by indirect by progeny measurements at a key unique location in the atlantic will open up multiple possibilities for climate science as well as in terms of radio protection and nuclear surveillance the radon observations will provide an accurate timevarying baseline reference level for european ghg enabling clearer distinction between emissions and slowly changing background levels in addition to ghg baseline estimates the quantification based on atmospheric radon concentration of the degree of terrestrial influence on air masses will significantly assist multiple atmospheric and multidisciplinary environmental studies these will be addressed in the project including the quantification of pollution events the investigation of the feedback of natural planktonic communities occurring at the surface north atlantic to ghg emissions and atmospheric studies of marine boundary layer clouds and aerosols the project will also increase understanding on wet deposition and meteorological processes influencing ambient gamma dose rate that need to be taken into account in setting threshold alarm levels of nuclear surveillance networks for radiological protection purposes
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commercialisation and scale up of a vaginal microbiome screening service with a menstrual tampon collection device and a digital layer to provide diagnosis disease risk evaluation and aftercare
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vms is a homebased gynaecological test kit using a menstrual tampon for sample collection vms will improve the accuracy and convenience with which sti vaginal infections and hpv screening is undertaken daye has patented the proprietary protocol for dna extraction from a tampon for pcr analysis testing for 16 different factors at a time vms can be used to detect vaginal dysbiosis hpv and stis like chlamydia gonorrhea and trichomoniasis vaginal microbiome screening with vms will unlock invaluable insights into our customers vaginal health theres a direct correlation between vaginal microbiome health and the likelihood of contracting an sti developing a gynecological cancer experiencing fertility and pregnancy challenges as well as susceptibility to recurrent vaginal and urethral infections post screen vms will offer comprehensive aftercare including prescriptions doctor consultations booking inperson visits and vaginal microbiome enhancement plan with probiotics
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knowledge and skills transfer for the applications of nanotechnology in biosensors for foodborne pathogens
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the know4nano project aims to unlock synergetic research and innovation potential between eupartner institutions and biosense institute bios to enhance the research and management capacity of bios staff in the field of bionanotechnology bnt project management and technology transfer to perform research activities toward the development of innovative and userfriendly personalized pointofcare diagnostic tests for food safety applications along the farmtofork food chain and unlock existing research potential and applicability of research results good practice innovation and scientific excellence from the leading european research institutions in the field of bntcatalan institute of nanoscience and nanotechnology barcelona spain with expertise in nanotechnology and nanosciencebased biosensors and microfluidics national research council rome italy an expert in molecular biology optical biosensors biosensors testing and validation and food safetyuniversity of chemistry and technology prague czech republic an expert in materials science materials synthesis functionalization and characterization of materialswill be transferred to bios by establishing a knowledge transfer platform based on carefully designed mobilities trainings and novel approaches in mutual collaboration to increase research excellence and innovation potential for all partners in bionanotechnology with a principal focus on bios know4nano will enable researchers from bios to acquire essential expertise competencies and skills in the field of nanomaterials biosensors microfluidics and food safety and enhance bios research management capacities and administrative skills for further commercialization exploitation and dissemination of results with the goal to increase its attractiveness in the region and eu as a potential collaboration in future project capable to generate new breakthrough results and markerready products
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east africas professionals in the making of our global information society
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infosoc critically historicises our contemporary information society demonstrating its global roots through original research into the lives of east african information professionals during a period of cold war internationalisms 1950s80s to understand the persistence of information inequality we need to place contestations over information in their sociopolitical contexts and historicise the social science disciplines that codified the meaning and power of information this interdisciplinary project places information professionals journalists librarians broadcasters and government information officers at its centre how did trainers trainees and new professionals imagine and use what they called information and crucially with what consequences for our global information society to answer this question i will take my expertise in east africas global history into new interdisciplinary territory at a leading international institution for research on histories of mass communication freie universitaet berlin fub under the supervision of an expert in the field dr valeska huber two substantial secondments in east african institutions st augustine university tanzania saut and the british institute in east africa biea will enhance infosocs innovative methodological basis and broaden its societal impact through a programme of trainingthroughresearch and a targeted communication and dissemination strategy including a hybrid workshop organised in berlin the pf will allow me to pioneer a new subfield of global information history and to demonstrate the pertinence of the east african case to academic audiences beyond african history as well as to public audiences in europe and east africa by the end of the pf i will have established an independent research profile as a publicfacing scholar with a researchdriven teaching portfolio and a commitment to sustainable collaborations between european and east african institutions
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budgeting for the future understanding the allocation of climate finance in the global south
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the impact of climate change on peoples lives and livelihoods is increasingly hard to ignore and is moreover characterized by trenchant inequities wealthy countries generate the vast majority of global co2 emissions but poor nations overwhelmingly suffer the consequences in response wealthy nations have pledged to mobilize us100 billion annually in climate finance to help their more vulnerable counterparts the past decade has seen climate finance nearly double but we know very little about what happens when these resources reach their intended beneficiaries in the global south as such we lack information about where and how climate finance can have the greatest impact and what constitutes the greatest areas of unmet need climatefigs develops a new theory to understand the allocation and spending of climate finance within global south countries the project considers how leaders characteristics including their gender and age condition their responses as well as the relative emphasis they place on mitigation ie risk protection vs adaptation ie risk management this approach recognizes the agency of global south leaders and expands the knowledge frontier on substantive representation distributive politics and environmental policymaking climatefigs breaks empirical ground by creating new global data on the mobilization of climate finance as well as by studying detailed patterns of budget allocation and expenditure in three purposefully selected african countries the project further adapts methods from social activism to map the power dynamics that drive climate finance decision making within countries and traces the processes that lead certain sectors and districts to be prioritized climatefigs is thus poised to generate knowledge to address one of the worlds most wicked problems how can we avert the most devastating impacts of climate change for the worlds most vulnerable
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humanitarian observatories building a knowledge and advocacy network on humanitarian governance
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this project aims to test demonstrate and validate the effectiveness of countrybased humanitarian observatories as a way for localized knowledgebuilding and reform in the humanitarian field can be advanced from crisisaffected places as a development of the ercfunded humgov project humanitarian observatories are envisioned as a locally embedded knowledge and advocacy network a means through which humanitarian governance can be understood reimagined or reformed from below humanitarian needs stemming from various forms of crisis are escalating with over 301 million peopleor more than 1 in 27 individuals worldwiderelying on humanitarian assistance for survival as the demand for humanitarian aid rises collaborative efforts with local and national partners are crucial yet it has been a longstanding critique that humanitarian programming is most often topdown despite efforts for reform within the sector the influence of actors from crisisaffected countries remains limited and the voices of affected populations are often left out of policy development and strategy reinforcing unequal power relationships between international aid providers and local actors humanitarian observatories contribute to addressing this challenge contextually rooted multiactor and selfgoverning humanitarian observatories established in areas affected by crises create space for relevant actors to come together and research advocate and work on priorities that they set for humanitarian action and reform in their context building on the groundwork laid by the humgov project this proposal seeks to test and refine the potential of humanitarian observatories through research and networkbuilding activities over 18 months the project will focus on refining methodologies and partnerships connecting observatorygenerated knowledge with policypractice realms and developing strategies to maximize innovation potential while overcoming organizational inertia
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setting up green energy research in serbia
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the eu aims to reduce greenhouse gas emissions and be climateneutral by 2050 serbia has also adopted the clean energy for all europeans package and agreed to a decarbonization roadmap the transition to netzero greenhouse gas emissions includes the decarbonization of the power sector however up to date the majority of the energy in serbia is fossilfueled with very little or no progress towards energy decarbonization moreover pollution in serbia is reaching alarming numbers placing it as one of the leading countries in europe related to bad air quality and pollution nonetheless research capacity in the power system decarbonization domain at ub as well as other actors in serbia and the region are undeveloped and insufficient for competitive r i therefore sunrise aims to support the power system department the university of belgrade school of electrical engineering in improving excellence capacity in the field of power system decarbonization research excellence will be promoted in three dimensions by improving research infrastructure through the development of realtime simulation laboratory for power system simulation upskilling research staff through training and mobility the development of new approaches in exploratory research projects with partners furthermore as network and collaboration between ub and other research institutions in the eu is modest or nonexistent as well as low linkages between ub and industry the special focus in sunrise will be given to mobility and networking activities one more sunrise objective is to improve the research management and administrative skills of the staff at ub to enhance funding attraction and participation in international research projects sunrise partners have a long experience and high scientific impact in the power system decarbonization field and they can support ub to improve scientific performance and research profile as well as participation success in he
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optimal immigration policy
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international migration affects the lives of millions both at origin and at destination it is known to generate aggregate benefits for destination countries even though labor market prospects of some natives may be worsened depending on the type of migrants it can also benefit or harm origin countries the design of immigration policies that maximize benefits foster immigrant integration and compensate potential losers is key for overall welfare this project develops a systematic framework to design optimal immigration policies and provides a comprehensive evaluation of such policies welfare effectswe build our analysis focusing on five policy goals i redistribution policies that transfer some of the benefits from winners to losers ii optimal methods to assign immigrant visas iii preferential tax schemes for highearning foreigners that encourage positive selfselection in skills iv selective immigration policies that are not detrimental or even foster origin countries economic development and v spatial allocation policies for immigrants that incentivize the accumulation of skills and assimilationwe develop and estimate a dynamic equilibrium framework to achieve these goals the framework features among others human capital and labor supply decisions both at origin and destination endogenous migration and return migration decisions multiple sources of observed and unobserved heterogeneity a worldwide general equilibrium that accounts for aggregate and idiosyncratic uncertainty and the presence of knowledge spillovers and externalities from using skilled labor and capital equipment in production the richness of the model and the variety of datasets used in estimation are unprecedented which poses important methodological challenges we develop novel estimation algorithms that allow us to address these challenges we use the estimated model to design and evaluate optimal policies through simulations
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rewriting the ubiquitin code manipulating polyubiquitin chain linkage to investigate ubiquitin signalling in genome maintenance and beyond
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ubiquitylation is an essential posttranslational modification that governs the activities and interactions of cellular proteins the structural diversity of polyubiquitin chains collectively called the ubiquitin code is thought to determine the fate of the modified proteins although many analytical and inhibitory ubiquitinspecific reagents exist we lack the tools to create polyubiquitin chains of defined linkage on a protein of interest in cells to investigate their signalling functions we recently established a method to induce substratespecific polyubiquitylation via three major linkages m1 k48 and k63 based on this technology we now propose to develop a new generation of research tools for the scientific community this will include the identification and design of custom enzymes for assembling the rarer still poorly characterised noncanonical linkages and a functionalisation with modules for chain editing branching and the identification of effectors in a combination of biochemical cell biological and proteomic approaches we will then apply these tools to major genome maintenance pathways with prominent roles in the defence against disorders such as cancer and premature ageing specifically we will analyse the significance of noncanonical polyubiquitylation in the response to dna doublestrand breaks and the interplay between degradative and nondegradative ubiquitylation in the regulation of essential dna replication and repair factors we envision that our research will not only provide new insight into ubiquitin signalling in genome maintenance but the new technology developed in this project will facilitate future investigations of polyubiquitin chains their readers and their writers in other signalling pathways situated at the interface between proteostasis and genome maintenance this project will thus advance our understanding of two essential cellular surveillance systems with critical functions in human health and wellbeing
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learning and modeling the molecular response of single cells to drug perturbations
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advances in singlecell genomics scg allow us to read out a cells molecular state with unprecedented detail increasingly so across perturbations to fully understand a cellular system one must be able to predict its internal state in response to all perturbations yet such modeling in scg is currently limited to descriptive statistics building upon my expertise in machine learning i propose to systematically model a cells behavior under perturbation focusing on the largely untouched area of druginduced perturbations with multiomics scg readouts a sufficiently generic model will predict perturbed cellular states enabling the design of optimal treatments in new celltypes in a pilot study we predicted gene expression changes of a cell ensemble in response to stimuli deepcell builds upon this approach based on a multicondition multimodal deeplearning approach for both normal and spatiallyresolved genomics we will set up a constrained interpretable model for the cellular expression response to diverse perturbations the added flexibility of the deepcell model versus classical smallscale systems biology models will allow us to interrogate the effects of combined drug stimuli and characterize the gene regulatory landscape by interpretation of the learned deep networkdeepcell provides unique possibilities to capitalize on cellbased drug screens to address fundamental questions in gene regulation and predicting treatment outcomes as a proof of concept i will identify targets that regulate enteroendocrine lineage selection in the intestine i will set up a 500compound singlecell organoid rnaseq screen based on compounds from a spatial imaging screen across 200000 intestinal organoids both of which we will model with deepcell we will leverage those models to predict optimal treatment for obese mice deepcell opens up the possibility of in silico drug screens with the potential to expedite drug discovery and impact clinical settings
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tensors and neural networks for computational creativity
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creativity in language is ubiquitous it is abundantly present in work with an explicit creative intention such as literary novels or poems but weighty doses of creativity also pervade everyday language use we believe that a computational model of creativity that focuses on language will shed light on the enigmatic processes and interactions that come into play when we humans express ourselves in creative ways moreover natural language generation systems in order to produce realistic utterances need to be endowed with a certain capacity for creativity the main goal of this research project is to develop unsupervised models of language that exhibit creativity in order to do so we propose an integrated approach that combines a number of important and innovative techniques first of all we rely on constructs from linear algebra called tensors in order to express language content according to different parameters using tensors we are able to induce latent semantics from multiway cooccurrences of textual content which can subsequently be used for the generation of creative expressions secondly we rely on advanced machine learning techniques notably neural networks neural network techniques have recently shown impressive performance in a number of natural language processing tasks yet these techniques are mainly mimicking human language production and thus are showing little creativity in language generation by adapting neural network approaches in various ways as well as integrating them with our tensorbased approach we expect to develop algorithms that are able to grasp the meaning of textual content in a more profound and elaborate way and at the same time are able to express it with creative intent the project has the potential for groundbreaking results not only because it would deepen our understanding of creativity but also because of practical applications within the field of natural language processing
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a new drug to treat triple negative breast cancer
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rnuucell is developing a new drug to treat triple negative breast cancer tnbc for which there is not any specific and efficient treatment in the market making this disease an unmet clinical needthe aggressivity of tnbc is due to the easiness of its metastization expanding the cancer through the body inevitably leading to death so far we gathered a set of results showing the antimetastatic potential of our new drug which mode of action would conceptually be able to eliminate the deadliest feature of cancer cells their ability to invade and metastasize this happens because the target of our drug is the cells foundation ie the cytoskeleton thus destroying the cytoskeleton of cells is like shaking the foundations of a house it will be tumbledownwith the women techeu program we will consolidate the proofofconcept of the drugs efficiency against metastases through two sets of in vivo studies in nude mice and we will start the preclinical studies by performing pharmacokinetics drug absorption distribution metabolism and excretion also in view of the natural future development of our drug we will start to develop its synthesis scaleup from the milligram to the multigram scale women techeu program mentoring and coaching will be also key to consolidate our business plan and to approach partners and investors towards a fundraising level a in the near future this level of funding 1 m will enable to finish our preclinical studies and place rnuucell in the position to license its international patent one of the companys assets pt108082b ea038640b1 ep3227307b1 cn107466297b jp6726678b2 us15533289 under examination on canada brazil and india to a pharmaceutical company using a businesstobusiness strategy
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measuring illegal online pharmacies impact and coevolution
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the pharma analytics market reached 60b in revenues in 2021 and is expected to grow at a 20 annual rate in the coming years the data and business intelligence provided by pharma analytics companies around drug sales is of outmost importance for multiple stakeholders in the pharma industry eg manufacturers distributors and regulators who rely on this data for their decisionmaking however this data is becoming increasingly biased and myopic it only accounts for drug sales from legal pharmacies overlooking sales from illegal pharmacies this limitation is becoming more and more problematic since sales from illegal pharmacies mainly operating online are growing at a substantive pace the goal of this poc is to address this limitation through the development of a web service that will provide data and business analytics on drug sales by illegal online pharmacies iops this web service will allow potential users to visualize market trends download data and develop customized reports on iops the goal of this poc is to develop a web service api that will provide data and business analytics on drug sales by illegal online pharmacies iops through a web portal this web service will allow potential users to visualize market trends download data and develop customized reports and will be provided following a payperuse commercial structure while multiple stakeholders in the pharma industry are potentially interested in this data eg manufacturers distributors pharma analytics companies policymakers and law enforcement authorities this data is currently unavailable due to the obscure nature of iops activities the web service proposed in this poc will generate such data through the algorithms designed in the illegalpharma ercfunded project accordingly this poc outlines the technological and commercial processes that will be implemented to transform the research generated in illegalpharma into a business innovation with market potential
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overcoming digital divide in europe and southeast asia
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digitalization has been in the epicenter of interest during the hard times of covid19 and has enabled governments and individuals to cope with the scientific and socioeconomic problems created by the pandemic both basic and advanced digital technologies as well as digital skills have been engaged to sustain the functioning of the economy and society by allowing the work to continue tracking the spread of the virus and accelerating research for medications and vaccines covid19 pandemic has shown more than anything else the utmost importance of digital assets and the need for further development towards a resilient digital transformation strengthening the digital economy and society has been one of the 6 strategic priorities of the 2021 european commission work programme with a goal of making this europes digital decade digitalization is the relevant issue in eu associated countries as well digital transformation might help eu associated countries to speed up convergence project and catch up developed eu economies even particularly topical problem is digitalization in developing countries the digital transformation and its support would lead to higher economic growth and sustainable development and the increasing of the quality of life the proposed project is as timely as ever considering the current situation of digitalization in the eu eu associated countries montenegro and developing countries in southeast asia region indonesia malaysia and thailand the focus of the project is the cooperation of the academic staff and doctoral students to engage in the research in the field of digitalization exchange their knowledge ideas and provide meaningful outputs and establish research collaboration in the field of digitalization
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mapping the behavioural causes of weight change variability with genetic lottery
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obesity is a heritable chronic condition costing 2 gdp worldwide many obesity treatments behavioural pharmacological and surgical have been developed intriguingly peoples responses to treatments vary widely some may lose a lot of weight whereas others may even gain weight to predict such weight change variability close to 200 measures have been proposed in the past the measures can be organised into a pebbl framework across five domains psychosocial environment behavioural biology and life quality still there are too many measures to be used as predictors or intervention targets to move the field forward we propose a novel 3step obecause pipeline consisting of consolidation genomic causation and validation 1 in consolidation we will use machine learning to find bestpredicting pebbl measures in several largescale weight loss datasets the pebbl measures will be integrated into a new pebbl short questionnaire with wide coverage and good psychometric properties the questionnaire will be then distributed to all participants of estonian biobank to study the genomics of pebbl 2 for genomic causation we will detect genetic variants behind pebbl measures and weight change knowing these variants enables discovering additions to the pebbl framework through genetic correlations and functional mapping importantly as genetic variants are randomised through genetic lottery they enable systematic causal mapping of pebbl measures that have causal effects on weight change 3 for validation these causal measures will be used as inputs to design an obecause toolbox of weight loss interventions the value of these interventions will be tested in a commercial weight loss app in summary the obecause pipeline of narrowing scattered associations down to potential causal mechanisms with machine learning and genomic causal inference will set a new standard for the behavioural health sciences allowing for quicker discovery of intervention targets
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netzero selfadaptive activation of distributed selfresilient augmented services
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the ambition of the natwork project is to set the foundations and deploy the very first economically realistic energy efficient and viable bioinspired aibased 6g cybersecurity and resilience framework for intelligent networking and services taking a holistic approach and considering all elements in a crosssector business environment to address the diverse requirements and challenges that arise the natwork project aims to develop a novel aileveraged selfadaptive security mechanism for 6g networks based on resilient biomimicry principles the goal is to improve the malleability and the selfresilience of future 6g network ecosystems to offer augmented and secure services at the lowest energy costs the principle premise is to empower various entities of 6g ecosystems with the ability to selfregulate their conditions to provide service continuity in compliance with service slas the secure federated learning architecture of natwork will be based on decentralized defensive ai models embedded in disaggregated 6g network physical layer smart edge network interface cards and ran devices with p4based programmable data plane and advanced dpu acceleration with local feature extraction at wirespeed and ai model training among the key 6g security challenges that natwork aims to alleviate are moving target defense and adaptive response to incidents the employment of net zero ai and energyefficient security for sustainable networks the detection of new forms of attacks bearing deep control flow monitoring as well as the elaboration of a continuum of security for payload deployment fostering secure migration of novel forms of innetwork operations and secure distributed computations
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dynamics of p53 mutant reactivation and the anticarcinogenic action of engineered resveratrol analogues
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the project proposal aims to engineer a bacterial host to produce variants of secondary metabolite resveratrol and address the interrelationship between dynamics structure and function of a system of high medical interest the tumor suppressor protein p53 the study considers to elucidate the mode of action of these molecules against the p53 mutants and work on new concepts for cancer therapy inside the cell the folding of a protein is a fast and robust process sometimes however sudden changes in the balance between different existing forces result in incorrect folding of the peptide chain which ends up generating amyloid aggregates within the cell that lead to the gain of toxic function since these aggregates can conduct to death of the cell in question most amyloidogenic pathologies are neurodegenerative however the aggregation also plays an important role in cancer the project provides a broad framework for the study of the resveratrol derivatives acting as p53 aggregation inhibitors by using cuttingedge tools of computational resources metabolic engineering and structural biology but could in principal be applied to exploit the chemical diversity of other biocompounds similarly intending to act as less cytotoxic agents in a more effective antineoplastic therapy which represents one of the major existing scientific gaps it is a proposal on a very important topic that will be studied from a unique perspective
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towards the development of a hydrogen valley demonstrating applications in an integrated ecosystem in greece
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trirs is greeces first hydrogen valley brings together business knowledge and regional interests the trirs valley starts as a small scale valley but has a tremendous upward perspective over a large part of the balkans southeastern europe and the wider area of eastern mediterranean the valley will be built around the nucleus of mohs corinth refinery complex from a business perspective the project has strong transeuropean interest as 80 of the refinery sales are generated outside of greece rendering it internationally oriented by default creating and building a valley using the refinery as hydrogen generator accelerates the transition with an annual production of 2410 tons of green hydrogen that will be utilised in the production of low and no carbon footprint energy and industrial products and will be injected in the natural gas grid creating a hydrogen backbone of full eu interest high visibility actions in mobility will include one 1 shortsea ferry ship three 3 public transport buses and at least two 2 cars knowledge and innovations are spurred through the intensive collaboration with knowledge institutes and smes the participation of the local and regional governments assures the component of public acceptance understanding and advocacy generating interest to many parties supporting regional economic growth the learnings from heavenn and wiga pg valleys will be replicated with the specific knowledge of the greek and broader connected geographies trirs entails an investment of 115 mil eur initially by project partners up to 408 million eur potential directindirect leverage of investments several thousand people will be employed during the realisation of the valley project which will promote new skills development the consortium partners are creating a true new perspective in the region transitioning from a traditional refinery complex to a stateofthe art future oriented energy and hydrogen ecosystem in the region
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memoryrna the role of epitranscriptomics in thermomemory regulation
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plants live in constantly changing environments and the increased frequency of extreme weather as a result of climate change will exacerbate such stresses the memoryrna project aims to expand the fundamental knowledge of nongeneticallybased regulations of the plant transcriptome during heat stress hs posttranscriptional modifications of rna create an additional layer to reversibly control rna fate the sophisticated and poorly understood thermomemory phenomenon represents a powerful system to study the role of the rna modifications and its high impact on rna metabolism to reprogram the transcriptome thus leading plants to adapt and survive to unravel the role of epitranscriptomicbased reprogramming of the transcriptome of thermomemory rnas at the shoot apical meristem the project aims to i reveal the m5c and m6a modifications transcriptomewide that actively contribute to the global cellular response to hs ii characterize the m5c and m6a marks on thermomemomery mrnas and iii determine how a m6a reader protein ect2 is regulated upon hs and its functional role on transcriptional regulation data and biological resources obtained by the team support the memoryrna project and incorporate a comprehensive set of cuttingedge technologies and approaches including i direct sequencing of longread fragments and computational analysis for accurate mapping of rna marks ii antibodybased techniques and mutant plants to validate and characterise the function of m5c and m6acontaining mrnas and iii rna and fluorescence in situ hybridization and laser confocal microscopy to investigate the role of ect2 during thermomemory understanding the mechanisms that coordinate transcriptional activity of hsmemory genes in response to environmental stressors is of utmost importance to modern agriculture and throughout the the funding period opportunities for translation of our results to biotechnological application will be monitored and explored
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tungsten biocatalysis heavy metal enzymes for sustainable industrial biocatalysis
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europe needs a sustainable chemical industry which will only be realized by new breakthrough technologies industrial biotechnology is established in chemical manufacturing offering more efficient more specific safer and less energy demanding production but is held back by the limited number of enzyme classes in industrial use this project opens up an important new enzyme class of tungstencontaining enzymes wenzymes which catalyse amazing chemical reactions involving challenging low redox potential reduction reactions but are currently impossible to obtain economically and on scale to match industrial needs we need to produce wenzymes using an industrial workhorse microorganism such as e coli yet we discovered that wcofactor biosynthesis is the bottleneck preventing successful production of wenzymes in e coli we can solve this challenge by using cuttingedge computational enzyme design approaches we recently developed to create a completely new wcofactor biosynthesis pathway for e coli the wbiocat strains developed in this project will enable expression of new wenzymes from genetic databases and facilitate production of new engineered wenzymes the catalytic potential of these new wenzymes will be established and implemented in new processes exciting new reaction scope in biocatalytic co2 reduction to valuable chemicals and birch reduction of aromatic compounds will be explored alongside the alreadyestablished and broadly applicable carboxylic acid reductions wbiocat will be the breakthrough to make wenzymes accessible for industry as a proof of concept a hydrogendriven process to convert plantderived oleic acid to the emollient ester oleyl oleate will be created oleyl oleate is used in many cosmetic products used daily by millions of people this process will be demonstrated in multigram yield in scalable industriallyrelevant hydrogenation reactors together with market research to address a pathway to commercialisation
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ssmart uupgraded assetvalues and quality of life ppublic private partnership eextended energy efficiency rrenewables triggered by the project shsocial housing iinvestment nnet zero eeuropean
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the objectives and impacts of the supershine project will assist and support the european commission to implement the european green deal particular attention will be paid to the renovation of social housing to help households who struggle to pay their energy bills in addition supershine will also contribute to the decrease of energy poverty the supershine lighthouse districts will be characterised by energy efficient buildings low carbon mobility smart grids efficient water and waste management all underpinned by responsive technologies that optimise resources while promoting wellbeing and sustainable lifestyles more specifically supershine will adopt an integrated strategy with these key principles aenergy efficiency first b affordability c decarbonisation and integration of renewables d lifecycle thinking and circularity e high health and environmental standards by promoting sustainable energy behaviours f tackling the twin challenges of the green and digital transitions together g respect for aesthetics and architectural quality the main areas of intervention are a strengthening information and incentives for public and private owners and tenants to undertake renovations while improving community participation or inspiring new patterns of citizen behaviour bensuring adequate and welltargeted funding by supporting innovative bottom up financial solutions such as public private partnerships ppps and green public procurement gpp and collaborating with innovative local small and medium enterprises smes c promoting comprehensive and integrated renovation interventions d making the construction ecosystem fit to deliver sustainable renovation based on circular solutions use and reuse of sustainable materials and the integration of naturebased solutions while reducing whole lifecycle carbon emissions
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dynamicsaware theory of deep learning
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the recent advances in deep learning dl have transformed many scientific domains and have had major impacts on industry and society despite their success dl methods do not obey most of the wisdoms of statistical learning theory and the vast majority of the current dl techniques mainly stand as poorly understood blackbox algorithms even though dl theory has been a very active research field in the past few years there is a significant gap between the current theory and practice i the current theory often becomes vacuous for models with large number of parameters which is typical in dl and ii it cannot capture the interaction between data architecture training algorithm and its hyperparameters which can have drastic effects on the overall performance due to this lack of theoretical understanding designing new dl systems has been dominantly performed by adhoc trialanderror approachesthe main objective of this proposal is to develop a mathematically sound and practically relevant theory for dl which will ultimately serve as the basis of a software library that provides practical tools for dl practitioners in particular i we will develop error bounds that closely reflect the true empirical performance by explicitly incorporating the dynamics aspect of training ii we will develop new model selection training and compression algorithms with reduced timememorystorage complexity by exploiting the developed theoryto achieve the expected breakthroughs we will develop a novel theoretical framework which will enable tight analysis of learning algorithms in the lens of dynamical systems theory the outcomes will help relieve dl from being a blackbox system and avoid the heuristic design process we will produce comprehensive opensource software tools adapted to all popular dl libraries and test the developed algorithms on a wide range of real applications arising in computer vision audiomusicnatural language processing
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untwist policy recommendations to regain losers of feminism as mainstream voters
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untwist aims to promote gender equality as a core value of the eu defending it from the emerging threat that the oppositional gender rhetoric from extreme populist parties represents by developing policy recommendations that uphold gender equality as both a value and a way of life our project will contribute to shaping the global future thus fulfilling relevant objectives in the eus political agenda for the period 20192024 by understanding if extreme populist parties are acting as niche parties substantively representing but also twisting the needs and demands of citizens at the margins who feel abandoned or disempowered by current mainstream feminist discourses and policies it will cocreate alternative ways of addressing those citizens thus developing and implementing new policies that can counter genderequalityrepressive strategies and the policies of extreme populist parties representative democracies will consequently be reinvigorated and the citizenship empowered by a better safeguarding of gender equalityuntwists main working strategy toward that end will consist of empowering nonradicalpopulist parties in europe to improve their representation of the genderbased interests of the citizenry through the definition enhancement and transfer of a policy recommendation handbook with evidencebased policy recommendations that 1 help mainstream parties improve their substantive representation of sex and genderbased needs and demands in ways that diminish the appeal of extreme populist messages untwisting oppositional gender messages particularly from rightwing populism and 2 contributes to the widening horizon of gender expectations and overcomes current gender fatigue among citizens the improvement in substantive democratic representation by these parties will decrease citizens interest in the antifeminist messages of radical or populist parties
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physicsinformed datadriven analysis for wind power hubs
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to address the challenges of climate change and energy crisis the european union eu is accelerating the transition to carbon neutrality using wind power as the key driver to fully exploit eus offshore wind resources the strategy of constructing wind power hub has been devised recently and will be implemented in the north sea however integration of numerous power converters in wind power hub forms a sophisticated system making analysis difficult this project phydawn will tackle these challenges by developing physicsinformed datadriven modelling and stability assessment methodologies for wind power hub firstly effective impedance model of voltage source converters for varying operation points will be developed based on physicsinformed machine learning next a scalable aggregated model for wind power hub will be proposed using transfer learning improving modelling effectiveness under insufficient data then the stability of wind power hub will be assessed in a probabilistic manner realizing intensive stability analysis for internal converters a software toolbox will also be developed for fully exploitation of the research results in the industry the applicant has expertise in datadriven grid analysis during the project she will collaborate with the supervisor at aalborg university who has rich research experience on power converter modelling and analysis besides she will collaborate with the secondment supervisor at kth royal institute of technology who is an expert of control theory through these collaborations phydawn will create novel knowledge for wind power hubs and also strengthen the applicants career prospects the research results will be disseminated by publications in top journals and conferences producing a positive impact on raising the europe knowledge base moreover communication activities are planned to expand the impact of this project to the general public committing to eus carbon neutrality ambition
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twinning for a european consortium of rectal cancer research institutions through stepping up scientific technological and innovation excellence of iors
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neoadjuvant chemoradiotherapy crt is the gold standard in locally advanced rectal cancer larc but the response is not uniform among patients and improvements are currently being assessed profiling the response to crt in patients with larc would enable more adequate selection of patients who would benefit most from crt while minimizing adverse effects and toxicity patients with a favorable response to crt might be candidates for a less invasive surgical approach or for enrollment in a watch and wait approach in the case of a complete clinical response ccr this would increase their quality of life and contribute to the overall reduction of treatment cost identification of novel therapeutic targets might also benefit rectal cancer patients who do not respond well to neoadjuvant crtthe main aim of the stepupiors project is to establish a european consortium of research institutions dedicated to defining prognostic biomarkers in rectal cancer specific project objectives that would enable addressing this unmet clinical need are objective 1 determine the molecular profile of response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer through a newly formed rectal cancer consortium with complementary expertiseobjective 2 strengthen the research management and administrative abilities of the institute for oncology and radiology of serbia iors located in belgrade serbia along with the establishment of a rectal cancer biobankobjective 3 establish a longlasting knowledge personnel and sample exchange between participating institutions in the rectal cancer consortiumthe stepupiors project aligns with europes beating cancer plan and the horizon europe strategic plan 20212024 within the health cluster through setting up a research consortium that will enable improvement of rectal cancer prognosis monitoring and treatment and lead to better health outcomes
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interrogating basal ganglia reinforcement with deep brain stimulation in parkinsons disease
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dopamine and the basal ganglia have been conserved over more than 500 million years of evolution they are fundamental to animal and human behaviour parkinsons disease pd is associated with loss of dopaminergic innervation to the basal ganglia over 6 million people suffer from the debilitating symptoms of pd that span disturbance of emotion cognition and movement there is a pressing need to understand the pathogenesis of these symptoms but an integrated account of dopamine and basal ganglia function is lacking this constitutes a significant roadblock to scientific and therapeutic advances to overcome this roadblock reinforcebg poses the novel unconventional hypothesis that loss of dopamine in pd does not impair movement per se but leads to chronic negative reinforcement of neural population dynamics conversely in the healthy state transient dopamine signals may stabilize cortexbasal ganglia activity to facilitate reentry and refinement of cortical output to address this hypothesis reinforcebg will combine invasive electrocorticography and local field potential recordings with closedloop deep brain stimulation in pd patients aim 1 will investigate how basal ganglia pathways coordinate neuromuscular adaptation aim 2 will shed light on basal ganglia reinforcement in multiple behavioural domains including movement gait speech and spatial navigation in virtual reality aim 3 will develop a neuroprosthetic braincomputer interface that aims to modulate basal ganglia reinforcement reinforcebg deviates from outdated models on pro vs antikinetic go and nogo pathways and promises a holisticreinforcement centred view of basal ganglia function it will leverage the unprecedented spatiotemporal precision of neuromodulation for the development of an innovative brain circuit intervention that modulates neural reinforcement in real time this opens new horizons for the interdisciplinary treatment of brain disorders affecting the dopaminergic system
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a design principle for predicting flexible metalorganic frameworks
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metalorganic frameworks mofs are porous organicinorganic hybrid materials that hold the potential for developing newtechnologies to tackle some of the pressing global challenges such as pollution climate change and energy crisis their typical lowmass densities high internal surface area large pore volumes and facile chemistry makes them suitable for application in gas storagefiltration extraction catalysis and so on some mofs are known to show a substantial degree of structural flexibility wherein theframework reversibly expandscontracts when subjected to external stimuli like pressureheatlight or during absorptiondesorptionthis structural flexibility if fully understood can be used to enable the technological development of mofbased recyclable filtersswitchable catalysts threshold sensors stimulusinduced drug delivery systems with integrated keylock functionality compressiblegas tanks and so on however the origin of this flexibility has not yet been sufficiently understood to enable the rational design offlexible mofs this research project aims to provide a conceptual understanding on the origin of this flexibility at the atomic regimeby analysing all unique building units topologies and frameworks of all published mofs to design a universally robust metric forpredicting flexibility and mechanical properties of mofs with the overarching goal of providing a theoretical methodology for thecrystal engineering of flexible mofs
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enhanced biomass valorisation by engineering of polyoxometalate catalysts
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this project builds on a recent and groundbreaking discovery of the pi in the field of homogeneously catalysed selective biomass valorisation materials technologies that promise improved catalytic performance are of utmost interest for a more sustainable chemical industry manipulating molecular catalysts like polyoxometalates pom in solution by tuning the solvent properties and gas atmospheres introduces a new paradigm in homogeneouscatalysed biomass valorisation technologiesit has been found that by using methanol as a cosolvent pom catalysts can completely suppress undesired total oxidation to co2 under oxidative conditions this drastically enhances the carbon efficiency from biomass to close to 100 yield remarkably this manipulating effect could be explained with the formation of a new vanadylmethanolatecomplex in methanolaqueous solutions having a methanol content of at least 10the proposed biovalcat project aims for developing this potentially disruptive technology towards an industrial viable biomass valorisation process by laying the foundations for a scalable safe and economic process for the oxidation of biomass to valuable carboxylic acid esters the project is structured according to the key challenges that have to be mastered in order to achieve this ambitious goal a investigations to identify the nature of the pomsolvent interactions b understanding and revealing the key organic mechanisms in solution c development of novel pom catalysts specifically optimised to perform in aqueousalcoholic solvent mixtures d extension of the substrate and product scope to industrially viable biomass feedstock e process development with special emphasis on safety aspects process intensification as well as product isolation and catalyst recoverywith the proposed project the pi aims for paving the scientific route to novel lowcost biomass utilisation technologies with great promise for decentralised valorisation of biogenic waste
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relatedness and the evolutionary pathway to worker sterility in ants
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the sterile worker castes found in the colonies of social insects are often cited as archetypal examples of altruism in nature the challenge is to explain why losing the ability to reproduce has evolved as a superior strategy for transmitting genes into future generations the leading explanation for the evolution of worker sterility is the monogamy hypothesis the idea is that workers dont need to reproduce because they can transmit their genes indirectly by improving the reproductive success of the queen who carries the same genes for this to work the queen should be monogamously mated ensuring workers are raising full siblings the genetic equivalent of their own young r 05 there has been no appropriate test of this hypothesis however and an alternative hypothesis that worker sterility evolved via the enforcement of cooperation by policing has not been ruled out according to the policing hypothesis workers suppress each others reproduction by eating each others eggs or through aggression leading to sterility through evolutionary time crucially policing is predicted to evolve when relatedness is low in contrast to the monogamy hypothesishere i propose an interdisciplinary approach that combines a cuttingedge phylogenetic comparative analysis across 500 ant species with novel labbased experiments on the socially polymorphic ant formica exsecta to test between the low and high relatedness evolutionary pathways to worker sterility contrary to common belief workers in most ant species can lay eggs due to their haplodiploid sex determination system making them an ideal system for answering this question this project will fill a crucial gap in our knowledge of how complex life on earth evolved and potentially overturn the longheld hypothesis that high relatedness is the only route to cooperation
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searching for oil spills on sea surfaces
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oil spills rapidly spread on sea surfaces covering wide areas assuming different appearances and thicknesses the faster the actions to detect stop and contain the released oil from spreading the higher the oil spill response osr success rate since cleanup effectiveness is higher over thicker layers of oil referred to as actionable oil detecting these regions is crucial to enhance oil recovery efficiency thus minimizing environmental and socioeconomic impacts the objective of searching for oil spills on sea surfaces soseas project is to develop an artificial intelligencebased system to extract relative oil thicknesses by using multifrequency and multiresolution synthetic aperture radars sar aerial reconnaissance is currently the most common method to estimate the extent thickness and volume of oil spills however it is subjective biased and imprecise demanding welltrained experts to visually estimate the extent of an oil slick and distinguish different oil appearances conversely sar are keyoperational sensors for oil pollution monitoring offering a synoptic view over affected sites acquiring images during day and night regardless of weather conditions the use of sar data to detect the location and extent of oil pollution as well as to discriminate it from false alarms has been wellresearched however oil slicks characterization is underexplored but a promising new and highly innovative research area owing to the increasing availability of free sar data the development of powerful learning algorithms combined with highperformance computing advances an automatic system welltrained to recognize patterns related to qualitative thickness ranging will indicate the actionable oil regions these outputs can offer a less subjective and more precise oil pollution assessment than that of visual reconnaissance improving situational awareness in time to guide trustworthy decisionmaking during cleanup operations
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challenges in competitive online optimisation
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online decisionmaking characterized by the need to make decisions without knowledge of the future lies at the heart of numerous applications despite its prevalence our grasp of effective strategies for handling the associated uncertainty remains poor through the lens of the established framework of online algorithms as well as the emerging field of learningaugmented algorithms this project aims to address central challenges in decision making under uncertaintywhile there has been extensive research on online algorithms many of the fields core challenges remain unresolved however several recent discoveries of new algorithmic design and analysis techniques have opened up novel avenues for overcoming previous obstaclesalongside these technical advancements the rise of machine learning is now significantly enriching our toolset for dealing with uncertainty this has motivated the recent emergence of the field of learningaugmented algorithms here an algorithms input is augmented with predictions aiming for nearoptimal performance if predictions are reasonably good while still retaining classical worstcase guarantees even for highly erroneous predictionsinspired by these recent developments this project aims to substantially elevate our understanding of decisionmaking under uncertainty the main objectives are 1 to explore new directions around the concept of work functions 2 to elevate the mirror descent technique into a generic tool for online algorithm design 3 to develop universal techniques for designing learningaugmented algorithms and 4 to expand the scope of learningaugmented algorithms to new domainsthe project addresses questions at the forefront of theoretical computer science building on the pis recent success in resolving several longstanding problems and strives for foundational contributions to the timely issue of leveraging machinelearned predictions for improved algorithm design
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experiencing access with interactive technologies
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how is access experienced in interaction with modern technologies humancomputer interaction hci has a tradition of asking questions around functionality in the context of assistive and accessible technologies however the additional aspects of lived experiences with disabilities are often secondary to the questions and interests driven by nondisabled researchers this approach risks producing artefacts that might be functionally accessible but are deemed as undesirable unwanted or even harmful by disabled communities themselves with an increased move towards digitising aspects of our everyday lives there is an urgent need to understand the fundamentals of how access can be conceptualised implemented and flexible to situated engagements accesstech investigates the deeper theories behind access as a component affecting interaction with technologies for disabled people through participatory research through design drawing on the pis outstanding track record in critical analysis and participatory design practices within hci including 14 awardwinning papers we approach experiences of access along four paths of inquiry 1 we identify the needed research and design parameters enabling us to produce knowledges about accessenabling technologies 2 we establish which methods are required to design and develop critical technologies that are rooted in disability cultures as well as accepted and desired by disabled people 3 we explore a range of different technologies to understand how they afford different kinds of access experiences 4 we conceptualise and articulate access experiences as a distinct aspect shaping the interactive characteristics of modern technologies on a theoretical level each of these paths informs disability centred practices and theories in hci though collectively accesstech represents a fundamental paradigm shift in the ways we encounter disabilities and technologies
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decisionmaking framework and processes for holistic evaluation of environmental and climate policies
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the dual climate change and biodiversity crises put an urgency for implementing inclusive just and effective policies while their inextricable nature calls for integrated assessment approaches that capture synergies and tradeoffs mainstream economic methods currently used in the appraisal of environmental policies fail to capture the complexity of the climatebiodiversityeconomy nexus even though uncertainty disruption and irreversibility are inherent to environmental challenges these are overlooked when designing and evaluating the performance of policies policy effectiveness and resilience against other impact areas such as quality of life financial stability political feasibility innovation is not included in policy appraisal rather policy evaluation is informed by a narrow set of metrics falling short of encompassing broader considerations of sustainability and wellbeingdecipher employs a systems and multidisciplinary approach using a diverse set of models methods and processes to significantly improve decisionmaking on climate change and biodiversity and enhance policy resilience and feasibility moving beyond stateoftheart we will establish a holistic and operational decisionmaking framework that integrates advanced economic and biophysical models empirical methods and stakeholder participation tools the novel framework incorporates environmental damages in the economic decisions of agents and introduces a riskopportunity approach for decision making to offer critical insights on system dynamics and risks the models developed will be equipped with innovative features including improved representations of agent behavior technology innovation financial risk valuation and the capacity to assess extreme events and critical tipping points the new decisionmaking framework will be the endresult of an iterative cocreation process with stakeholders and applied under realworld conditions in the assessment of flagship eu policies
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unravelling evolutionary responses of lagomorphs to climate perturbations geohistorical data integration for presentday biodiversity conservation
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the lagomorphs rabbits hares and pikas are a successful mammalian group which play key roles in many ecosystems sustaining other species communities and populations the ongoing climate change is pushing most of their species into the extinction and their demise can entail the decline of their communities and ecological systems consequence of a dramatic knockon effect the present project revobbit aims to contribute to search solutions to this severe challenge from an unexplored perspective in this mammalian group the conservation palaeontology through the study of the bone and teeth of extinct lagomorphs it is possible to reveal the biological strategies and evolutionary shifts of those species or populations that were resilient and survived to past global warmings and coolings this is a very significant knowledge to be considered in the conservation decisionmaking process of extant relatives with this ultimate goal revobbit will study the extinct rabbits and hares from sierra de atapuerca pleistocene which endured important glacial and interglacial periods using trusty morphological methods and frontier molecular and geochemical techniques teeth and postcranial bones will be assessed disclosing their weight diet genetic size and diversity as well as the past environmental conditions where they lived temperature humidity etc the subsequent statistical analysis will let to identify the most significant ecological stressors and drivers that were involved in the evolution of lagomorphs the results obtained in revobbit will be the first step to build a big deeptime database of the lagomorph palaeobiology and to develop predictive models of biotic response at present the significant knowledge gap in the palaeobiology and palaeoecology of this mammalian group prevents that palaeontological data will be considered in the protocol conservation design of extant relatives
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strengthening epidemiological genomic and community surveillance of mpox virus mpxv at the congo river border for drc and roc
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the spread of mpox virus mpxv in subsaharan africa specifically democratic republic of congo drc and republic of congo roc presents an urgent public health concern with global implications mpxv cases have been reported across 114 countries with 89752 confirmed reports and 150 deaths it has the highest prevalence in drc and has resulted in twice the number of deaths in the african region compared to europe roc a drc bordering country is also experiencing a surge in positive cases highlighting an urgent need for datadriven efforts to identify transmission routes and implement public health initiatives mpoxprobe is responding to this call for action with an international consortium and activities in three main pillars 1 improving epidemiological surveillance of mpox with new diagnostics and sampling efforts including highrisk areas and vulnerable populations 2 capacity building to improve diagnostic and research capacities of researchers and public health workers in drc and roc 3 strengthening public health response by sharing surveillance data and newly developed spatiotemporal risk and transmission models for mpox through mpoxprobe this consortium will create actionable data to uncover mpxv transmission routes and natural reservoirs facilitating development of effective interventional packages the transmission and risks models will allow prediction of future or emerging outbreaks and develop initiatives to prevent further spread together these efforts will benefit vulnerable populations and general public in subsaharan africa alike while also performing groundbreaking research to understand transmission mechanisms
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marte marine technology excellence hub for sustainable blue economy in baltics
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the marte project aims to facilitate sustainable blue growth in the baltic region by establishing estonian and latvian marine innovation excellence hub this will be achieved through the collaboration of diverse stakeholders including academic institutions taltech university of tartu ventspils university of applied sciences latvian institute of aquatic ecology public sector environmental investment centre kurzeme planning region saaremaa development centre latvian investment and development agency industry association of estonian marine industries port of ventspils and coastal communities wwf baltijas krasti saarte koostkogu by leveraging quadruplehelix collaborations marte will create a crossborder innovation strategy and supportive network for fostering new technologies throughout the marine industry value chain project objectives include collaborative rd ecosystem empowerment and policy influence for advancing marine technologies reinforcing stakeholder linkages improving ecosystem capacity building closing the knowledge gaps supporting smes and startups and elevating the visibility of the regional blue economy innovation ecosystems in alignment with eu green deal and regional smart specialization strategies the strategic framework focuses on marine technology innovation uptake in areas like offshore energy smart vessels and ports sustainable use of marine resources and marine ecosystem protection through a comprehensive approach encompassing stakeholder engagement and capacity building marte strives for a significant impact on the sustainable blue economy in baltics
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singlechip integration of mems micropumps with optical waveguides for laser absorption spectroscopy
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microbiological research is concerned with studies of microbial gas consumption and production which is tightly linked to natural greenhouse gas emissions but also sinks currently such studies require large and expensive instrumentation like gas chromatography systems which also sacrifice the sample during each measurement this affects the conditions of the sample and yields unsatisfactory temporal resolution due to the need for sample handling in this project i propose to leverage the latest advances in mems and nanophotonics to develop the first chip platform integrating optical waveguides with micropumps which will facilitate tuneable diode laser absorption spectroscopy tdlas under vacuum and in closed valume without sacrificing the sample gas with the addition of lasers and light detectors it will enable inexpensive low weight portable devices for realtime in situ trace gas detection such device will not only impact microbiological research but also sensor networks much needed eg in cities for controlling the air quality
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role of tissueresident folr2 macrophages as organizers of the tumor immune microenvironment
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the infiltration of cd8 t cells in tumors is crucial for the development of immunity against cancer we have recently identified a tissueresident macrophage population expressing the folate receptor 2 folr2 and infiltrating human and murine breast tumors we have shown that tumorinfiltrating cd8 t cell form lymphoid aggregate around folr2 macrophages in a perivascular niche the abundance of folr2 macrophages associates with lymphocyte infiltration the onset of tertiary lymphoid structures tls and favorable prognosis the abundance of tls in cancer correlates with better prognosis and clinical response to immunotherapy yet the molecular and cellular cues underlying tls formation in tumors are ill understood here we hypothesize that folr2 macrophages locally shape the compartment of tumorinfiltrating cd8 t cells mechanistically we will address if folr2 macrophages spark local cd8 t cell responses directly by interacting with t lymphocytes or indirectly by fostering tls formation to this end we will 1 develop a high dimensional analysis of the folr2 macrophageperivascular niche using tissue imaging spatial transcriptomic and singlecell rna sequencing 2 implement a new murine genetic model developed in the lab enabling the inducible ablation of folr2 macrophages and conditional gene inactivation 3 deliver a mechanistic analysis of cellular crosstalks involving folr2 macrophages and supporting the development and maintenance of tls lastly we will explore new immunotherapy strategies harnessing the immunogenic function of folr2 macrophages purposed to induce antitumor cd8 t cell responses to this end we will use antibodymediated targeting of folr2 macrophages to increase antigen presentation andor innate activation this study will provide fundamental insights on how tissueresident macrophages regulate tumorimmunity and a proof of concept for macrophage subsetspecific therapeutic interventions to treat cancer
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fishx providing a european fisheries dataspace through a consultative approach
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developing a fisheries dataspace fishx and insight platform based on smart orchestrated architecture and open interoperable technology via gaiax that will enable users to implement data to improve fishing methods increase yields protect endangered fisheries stocks and streamline mcs processes supporting the implemntation of the cfp the project will also be developing a series of industry and fisheries agency to consultatively participate in developing and refining new technologies in light of the changes and review of cfp
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identifying cellular and molecular features of protective antimalaria b cell response
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malaria is one of the leading lifethreatening diseases with a reported 627000 deaths and 241 million infections in 2020 mostly in lowincome countries despite the advances gained by control measures malaria incidence by plasmodium falciparum pf has plateaued in the last decade intervention through vaccines and antibody therapy shows promising results yet longlasting protective immunity remains unattainable antimalaria memory b cells comprise transcriptionally distinct subpopulations but their contribution to protective immunity is unclear here i plan to combine stateoftheart strategies to identify the cellular and molecular features of protective immunity offered by b cells and encoded antibodies respectively to that end i will use the unique samples from controlled human malaria infection trials to isolate memory b cells reactive to pf antigens obtain transcriptome and immunoglobulin ig gene sequences at the single cell level and measure antibody inhibitory properties at the monoclonal level transcripts signifying resting activated or exhausted phenotype will allow memory b cell clustering whereas ig gene features will help define clonal expansion and selection strength of antibodies by cloning and testing antibodies in specialized in vitro and in vivo assays i aim to discover potent inhibitory antibodies targeting different parasite developmental stages i will reveal the protective antibody molecular properties defined by ig gene features affinity and epitope specificity by singlecell level integration of transcriptome and antibody functionality for the first time this project will not only deliver potent parasite inhibitory antibodies of therapeutic potential but also lay a clear blueprint for attaining protective immunity through future vaccine designs this fellowship will support me in acquiring interdisciplinary expertise and advancing my career as a leading scientist in b cell immunology and malaria vaccinology
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innovative and safe microwavebased imaging technology to make breast cancer screening more accurate inclusive and femalefriendly
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breast cancer bc is the most common cancer in women worldwide affecting 1 in 8 women the figures from whos international agency for research on cancer estimate that in 2020 worldwide cases of breast cancer accounted for 24 of all cancers in women 226 million women and 685000 deaths globally mammography is the gold standard technology for breast screening which has been demonstrated through different randomized controlled trials to reduce breast cancer mortality however it has limitations and potential harms such as the use of ionizing radiation breast compression and performance restrictions due to the intrinsic nature of xrays in particular breast density is a restrictive property that can prevent breast cancer detection in mammograms of women with radiographically dense breasts other existing techniques mri ultrasound biopsy also suffer from drawbacks the overall aim of the mammoscreen proposal is to generate evidence about the use of mammowave a technology developed by ubt as screening technique in populationbased programs promoted by national or regional health systems to reach a revolution in breast screening to do so the consortium aims to confirm that mammowave reaches sensitivity90 and specificity95 in bc detection on 10000 study participants undergoing regular screening programs mammowave uses safe noninvasive and nonionizing microwave signals does not apply any compression to the breast and is very effective with dense breasts hence it can extend the breast screening to younger women aged 2049 98 million women in europe this group accounts for 30 of breast cancers in 2020 a comprehensive health economic assessment will be undertaken in this project and innovative way to implement patient engagement approaches is sought an effective policy makers engagement plan will be carried out to ensure that mammowave is recommended as screening approach due to the benefits that it brings to women and healthcare systems this action is part of the cancer mission cluster of projects on prevention including screening
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health safety and ergonomics for the future humancentric factory
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msds are inflammatory andor degenerative ailments affecting all sectors and all categories of workers and are by far the most common workrelated health problem in the european industry the biggest europewide occupational health survey found 46 of european workers reporting back pain while 43 had painful shoulder neck and upper limb muscles the social and economic consequences of this pandemic are now becoming clear msds accounted for 53 of workrelated diseases in the eu15 affecting 100 million people and causing half the absences from work and 60 of permanent work incapacitytotal cost of lost productivity attributable to msds is 2 of gross domestic product in the eu 240 billionhego is an innovative solution based on a proprietary set of motion capture algorithms able to recognize the workers gender age posture and movements in realtime and monitor ergonomics to adapt both workspace and workload according to workers personal profile to inform about potential msds risks and to provide insights for improving the work environments without the use of wearable devices and thanks to an automatic analysis of ergonomic risk factors hego can detect any incorrect posture of the worker or risky situations suggesting to operators the corrective actions the performance of the system is outstanding and has been validated in industrial facilities accuracy in recognition of skeleton points and movements 85 true positives and true negative in the recognition of an incorrect posture 90 data synchronization times 05 sec hego contributes to promote health and safety in industrial workplaces humancentered manufacturing concept by providing a low cost and reliable solution
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2d materialbased multiple oncotherapy against metastatic disease using a radically new computed tomography approach
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perseus intends to implement a novel nanotechnologybased cancer therapy for deepseated clinically unmanageable drugresistant and metastatic tumours practical use of nanotechnology in clinical cancer care is still in its infancy with a full potential yet to be realized the therapy is based on a novel nanosystem ns made of multifunctional 2d layered nanocrystals the ns enables under activation by computed tomography ct an effective multimodal therapy with minimal or no adverse effects this novel paradigm uses ct not to eradicate cancer but to trigger and to image the ns that locally activates nonmutagenic oncotherapies the therapies delivered are excited by the conversion of low energy xrays ie ct into heat reactive oxygen species and radiosensitizing agents xray irradiation can also induce immunogenic cell death with the exposure or release of neoantigens to trigger an anticancer immune response the use of xrays makes it possible to reach deepseated tumours that are inaccessible by visible or nearinfrared lightbased therapies in other words ct is the spark that lights the match this is a radical vision for an ambitious and highrisk project the current proposal targets a range of cancer types including metastatic triple negative breast cancer hepatocellular carcinoma colorectal cancer pancreatic ductal adenocarcinoma the ns is biocompatible and also totally inactive in absence of ct radiation ie the ns becomes active only where the ct beam is delivered so minimizing side effects at distal sitesthe therapy is agnostic to the type of cancer and to gender incidence because it doesnt affect the body biochemistry this is a second change of paradigm perseus vision is pursued by a multidisciplinary team composed of physicists chemists chemical engineers biologists physicians pharmacologists and radiologists working together to develop an innovative nanotechnological approach to address unmet clinical needs
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sensitive periods for audition teenagers with normal hearing hearing loss
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orienting oneself in a crowded playground understanding the teachers explanation despite the surrounding chatter lipreading to support auditory perception in noisy backgrounds these are all complex but essential skills for navigating lively schools in children with normal hearing the auditory system is functionally mature by 6 months of age yet complex auditory processing remains immature until mid to late adolescence strikingly adolescence is characterized by the onset of puberty which triggers a cascade of hormonal changes that drive neural plasticity and viceversa the overarching hypothesis of sensationahl is that adolescence might present a second sensitive period for complex auditory processing just like puberty is a gradual process spanning years sensitive periods unfold over time in this project i propose a multimethod approach to advance our understanding of maturation of complex auditory processing at adolescence specifically i will combine neuroendocrinology neuroimaging and psychophysics to identify the mechanisms that govern sensitive periods as they unfold over time first i will zoom in on the onset of puberty as a potential trigger for heightened plasticity associated with sensitive periods next i will investigate the effect of altered auditory input due to hearing loss noise exposition or auditory training on maturation of complex auditory processing in adolescents last i will focus on the braking factors that contribute to a decrease in plasticity observed at the end of adolescence sensationahl uses an innovative multidisciplinary perspective to tackle a remaining challenge in the field of developmental auditory cognitive neuroscience it will have significant impacts on public health ie prevention and clinical management of hearing loss language education ie speech perception in challenging backgrounds in children and theoretical understanding of sensitive periods across the lifespan
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increasing excellence in utilizing xray research and neutron scattering techniques at the university of tartu
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university of tartu utartu is the top research university in estonia and the baltic states the twinning project exanst increasing excellence in utilizing xray research and neutron scattering techniques at the university of tartu is concerned with further raising the research profile of utartu in the field of materials science by enabling researchers from utartu to take full advantage of the best european facilities for materials characterizationin particular the aim of this twinning project is to develop local expertise at utartu in the xray research techniques and neutron scattering techniques that are available at leading european synchrotrons and neutron facilities another aim of the project is to enhance expertise at utartu in the complementary computational methods that are used for materials modelling and analyzing the data generated in xray and neutron experimentsin order to achieve these aims utartu will team up with three advanced partners max iv sweden an advanced partner in synchrotron science forschungszentrum jülich fzj germany an advanced partner in neutron science and imperial college london icl uk an advanced partner in materials modelling besides the researchorientated endeavours the advanced partners will also provide guidance to utartu on research management strengthening cooperation between different institutes within utartu and tackling gender and diversity issuesas part of the twinning project utartu and the advanced partners will jointly carry out three pilot research projects concerned with i solidelectrolyteinterphases formed in energy storage devices based on ionic liquids ii photoactive proteins that can serve as optical switches or tuneable fluorescence markers and iii scintillator materials for radiation detection devices the pilot projects will give researchers from utartu an opportunity to gain firsthand experience in specific xray and neutron methods and modelling techniques
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engineered particles for chemical communication
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this project aims to the development of communication at the nanoscale and to advance in the understanding of how abiotic micronanoparticles can communicate between them and how micronanoparticles can communicate with living systems in this context an approach for establishing communication at the nanometric level is to mimic how nature communicates chemical or molecular communication based on transmitting and receiving information by means of molecules chemical messengers is one of the communication forms used by living organisms moreover many swarm systems found in nature communicate by modifying the environment using a concept called stigmergy the advantages of nanoparticles that communicate each to another are immediately obvious they constitute the basis of a dynamically interacting network eventually resulting in certain autonomy of the system if we would be able to raise the bases for communication between micronanoparticles and between micronanoparticles and cells the potential future applications in the biomedical field environmental research and industry technology are almost unlimited the project will establish firm handholds for the use of nanoparticles able to communicate from one to another and with cells in different applications the project will trace optimise and adapt all single steps from the idea to its implementation into applicable final systems with the aim of targeting issues that are difficult to address with conventional single particles the project is divided into three wps the first work package wp1 will create the basic elements for chemical communication in a more complex situation wp2 will use the tools of wp1 to develop systems able to establish communication between nanoparticles and living systems finally wp3 will generate nanosystems integrating gated nanoparticles and uptodate electronics to develop new communication structures
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accelerating dc dynamic cable technology for sustainable european electricity grid
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offshore wind generation is critical to realizing the european green deal and the broader eu ambition to reach climateneutrality by 2050 a third of all the offshore capacity installed could be floating since this technology unlocks wind potential in deeper waters at greater distances offshore technological trends have advanced towards highvoltage direct current hvdc as a mature solution over longdistance transmission dynamic export cables float in the water and carry power from the moving platform to the grid a key challenge is these cables need to accommodate combined electromechanicalthermal stresses no hvdc dynamic export cables currently exist and industry views this as a critical bottleneck for floating offshore wind development therefore this is a key enabling technology for secure grid integration of largescale and longdistance floating offshore wind power plantshvdc dynamic cables for floating offshore applications present unique challenges and risks from technical environmental operational and economical perspectives to address these complex interdisciplinary issues this project brings together a consortium from academic experts manufacturers users and insurance advisors the project will i validate the insulation reliability of a new dynamic hvdc export cable ii establish fundamental understanding of combined electromechanicalthermal aging mechanisms facilitating the development of test protocols that qualify and verify the integrity of hvdc dynamic cables iii identify routes for material sustainability for the cable to meet the eus circular economy ambitions and iv use the underpinning technical knowledge gained to reduce risk and build confidence for deploying the new cable technology and thus enhancing the insurability and financial viability of future floating offshore infrastructure as a result a prototype 320 kv dynamic hvdc export cable core will be designed manufactured and validated in this project
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exact results from broken symmetries
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symmetries serve as our main guide in studying physical phenomena the more symmetric a system is the more constrained are its degrees of freedom and the better prospects we have to understand and solve it significant progress has been achieved in the study of theories with high amounts of symmetry in the last decades supersymmetry and conformal invariance are the main reasons why the beautiful idea of holography materialised into the adscft correspondence and the discovery of hidden symmetries integrability in gauge theories was possible thanks to supersymmetry modern mathematical techniques allowed the evaluation of the otherwise unfathomable path integral and the comprehensive study of a long list of physical observables finally the successful revival of the conformal bootstrap program is based on conformal invariance these breakthroughs are unfortunately applicable only to theories with unrealistic amounts of symmetry brokensymmetries will break this impasse by applying the aforementioned ideas to more realistic theories where some of the supersymmetry andor conformal invariance are broken the key innovation of brokensymmetries is to still make use of a broken symmetry symmetries are captured by ward identities which we can still derive in various cases of symmetry breaking broken symmetries also imply powerful nonperturbative relations that observables obey we will combine these with the developments mentioned above producing novel exact results our approach will give a handle on otherwise insoluble problems the objectives of brokensymmetries are to obtain exact results while breaking1 conformal invariance spontaneously keeping supersymmetry intact2 supersymmetry explicitly keeping conformal invariance intact3 both supersymmetry and conformal invariance turning on the temperature4 supersymmetry generators in the context of integrability which get upgraded to quantum groups generators
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interdisciplinary model for understanding climate change adaptation
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social scientists have generally treated climate change cc vulnerability as homogeneous across social space underestimating the serious social distortions and conflicts it produces previous research conducted by the fellow suggests that cc impact is unevenly distributed even within small social units such as indian villages and fijian islands this project is guided by a hypothesis based on the fellows earlier work economic and social relations class gender ethnicity religion caste etc have an overwhelming impact on cc vulnerability and adaptation practices examining one of the regions in the world where the impact of cc is most advanced rural india the proposed project aims to generate detailed empirical data for tracing the connections between cc and existing social hierarchies under the supervision of a leading expert in modelling the result of empirical project will be turned into a generalisable model that can be used to understand and predict other agrarian societies experiences of cc and their differential modes of adaptation drawing on debates in economic sociology socioecology and environmental economics the projects empirical research will take place in two villages in maharashtra india where agriculture is in the midst of an ongoing crisis caused by biophysical processes the fellow will employ mixed methods using structured quantitative household surveys and semistructured qualitative interviews which will be collected during two visits to india the development of an evidencebased framework will be a pioneering contribution to our knowledge about the differing ways in which different members of a society are impacted by and respond to cc as such it addresses core eu objectives such as preparedness for the impact of climate change to protect lives and assets so helping confirm the eu as leading developer of knowledge solutions for the most pressing problems of humanity
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giantleaps during tumorigenesis dissecting saltatory evolution in cancer in the making
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tumorigenesis is an evolutionary process driven by gradual mutation acquisition to confer selective advantages to somatic cells dna rearrangements are the most common cancer driver mutation outnumbering base substitutions rearrangements amplify disrupt and fuse genes or alter their gene regulation ultimately driving adaptive changes to initiate cancer metastasis and therapy resistance cancer genomics has revealed that most of these alterations arise as complex genomic rearrangements cgrs where a multitude of changes arise in a short time while in most cases deleterious to the cell in rare cases cgrs confer an adaptive malignant phenotype in one giantleap through saltatory evolution events sees reminiscent of the hopeful monsters theorised by goldschmidt given their potential to overcome strong selective barriers it has been proposed that sees draw the line between benign lesions and lethal cancer and understanding their mechanisms is thus fundamental to tumour biology however the identity of cells undergoing sees has remained elusive with cancer genomics studies focusing typically on longestablished cancers rather than early or even initiating cancer cells intriguingly cgrs are largely explained by cascades of atypical cell nuclei ie nuclear atypias fueling rearrangement formation providing an opportunity to study seesbuilding a novel automated aidriven framework that couples imaging and singlecell multiomics we will leverage nuclear atypias as a phenotypic indicator to dissect principles and mechanisms of sees in the making and advance fundamental cancer biology using highly controllable cell lines and organoid models of colorectal cancer crc a tumour thought to be driven by sees we will unravel pathways genetic contexts and chromosomelevel constraints determining sees finally via validation in patient samples we will pave the way to determining sees in future clinical studies to advance precision oncology
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integration of citizen science best practices to upscale and maximise projects impact related to green deal and eu missions
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the main objective of the proj is to generate a eu wide network of connected citizen science projects a combined support program of direct funding and support services will be delivered to a group of high potential citizen science initiatives a strong set of communication dissemination and knowledge transfer will be implemented to engage all actors in the quadruple helix around the citizen science networks the project will consist of 5 work packages to be implemented for 36 months wp1 lead uam is devoted to coordinating the project in an efficient and transparent manner for the whole consortium wp2 lead sur with significant participation of uam will do a benchmarking on citizen projects to identify the barriers needs and challenges of the new era and eu missions to implement best practices on citizen science wp3 lead ut with significant participation from ulb and amu will focus on selecting and supporting the best citizen science initiatives to be upscaled to other eu regions from europe wp4 lead ulb with significant amus participation will be devoted to analyze the impact of the project and the transfer of the results to policy makers and regulators wp5 lead nkua will focus on communication dissemination sustainability and exploitation the expected results of the project are 1 tool kits training materials and methodologies about best practices on citizen science available to all stakeholders 2 network of connected citizen science initiatives sharing activities data and synergies 3 approach from cs subprojects to all actors of the quadruple helix to citizen science initiatives 4 interest by funding bodies in the cs subprojects supported 5 materials developed policy briefs or similar for the review of policies impacted the team is formed by the civis university alliance and mfn that brings to the project its expertise and networks generated thanks to its predominant role in eucitizenscience projects
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green nudges for sustainable forestry and agricultural practices post 2027
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behavioural and cognitive biases reduce the ability of decision makers to adopt the best solutions among the alternatives available borrowed from preexisting knowledge in psychology on priming nudges are defined as gentle interventions in a decision makers choice architecture default choice information presentation framing etc which enhance the likelihood of optimal choices forestagrigreennudges will first review initiatives and projects which explicitly or implicitly use green nudges to promote the use of sustainable practices in farming and forestry it will then assess each type of nudge according to two types of criteria 1 criteria associated with efficacy in promoting the use of the desired practices over a sufficiently long period and 2 criteria dictated by ethics and good practice principles transparency nudgee awareness participationselfregulation actorspecificity etc that guarantee the quality of the implementation process nudges will then be tested in the field and assessed on a grid reflecting the desiderata of efficacy and implementation quality the set of successful nudges will be enriched by innovative nudges based on information regarding attitudes and strategies of actors along the entire value chain the resulting set of nudges together with their corresponding implementation guidelines and the business models and market conditions which favor their application in agroforestry will be collected on an online tool inudge academy whose target audience will include policy makers wholesalers retailers farmers and foresters the tool will associate each nudge with implementation rules possible domains of application and possible risks in terms of efficacygood practice tradeoffs diffusion of the results among farming and forestry experts policy makers and actors along the value chain will maximise the impact of the project enhancing the adoption of sustainable practices in the farm and in the forest
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transient inactivation of hypothalamic hormone release to prevent posttraumatic stress sensitization
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stress is the foremost consequence of human life and became a pressing societal burden through the many sensory and societal pressures that have evolved during the past decades severe stress induces maladaptive changes in the brain that clinically manifest as posttraumatic stress disorder ptsd despite 4 of the population presenting ptsd only symptomatic therapies are available in the secretcells erc award we have identified a multimodal neurocircuit that induces brainwide sensitization to stress through the sequential recruitment of hypothalamic midbrain and then cortical neuronal circuits particularly we identified protein targets that can simultaneously affect hormone and neurotransmitter release within this circuit and whose knockout makes mice stress resilient therefore we used unbiased proteomics to select protein interactors that participate in the related signaling cascades determined the biochemical parameters of any such interaction and the xray structures of the relevant protein complexes moreso a highthroughput screen was established to identify inhibitors here we will apply this knowledge to use interacting proteins as templates for smallmolecule inhibitor discovery and hit optimization subsequently we will profile the pharmacology and cytotoxicity of the candidates in vitro thus we will take critical steps towards developing a circuit breaker that can inactivate the neuronal contingents that are causal to the development of ptsd thereby we will offer a fundamentally novel framework for pharmacotherapy
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treasures digging into dwarf galaxies
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the milky way is an environment rich with satellite galaxies stellar streams and accreted systems encoded in these structures is the formation and evolution of the galaxy through cosmic time fortunately these nearby relics can be studied in extraordinary detail star by star revealing the properties of the first stars the buildup of chemical elements in the universe the nature of dark matter and hierarchical galaxy formationto unlock these treasure troves of hidden information i designed a largescale survey 4dwarfs pi skladttir 520000 fibre hours that after a very competitive 2year selection has now been accepted as a 5year 4most survey starting in 2024 4dwarfs will collect highquality spectra of individual stars in close to 50 dwarf galaxies and dozens of stellar streams from systems currently undergoing disruptionthe goal of treasures is to execute and exploit this large 4dwarfs survey to its highest scientific potential treasures will provide the community with stellar ages radial velocities and chemical abundances for over 130000 stars and thus increase the number of stars with detailed abundance information in dwarf galaxies and streams by several orders of magnitude ensuring the farreaching impact of this project furthermore treasures will use stateoftheart models to contrast these new large data against theory and put in context with the milky way through an ambitious combination of modelling and data of unprecedented magnitude and completeness treasures will quantify and put fundamental constraints oni the properties of the first stars mass and energy distributionsii the origin of the chemical elements physics of stars supernovae and neutron star mergersiii hierarchical galaxy formation at the smallest mass scales and structure of dark matter halostreasures will thus paint a comprehensive picture of the formation and evolution of the milky way environment from cosmic dawn until the present day
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climatization of eu policies the case of maritime transport
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the objective of the research project titled climatization of eu policies the case of maritime transport euclimt is to explore in what ways climatization influences eu governance and impacts the power of the institutional actors to do so the case study of maritime transport will be employed as it is one of the main policy areas indicated in the fit for 55 package as crucial for the decarbonization of the european continent in more detail the project will analyze first the role of the supranational actors in promoting climate policies within the eu with a focus on maritime transport second the implementation of the new green maritime transport policies by key stakeholders within the eu member states and third the impact of the said new policies on the eus diplomatic positions at the international level and how these are perceived by third actors the deliverables of the project will cover a broad array of outputs such as scholarly articles policy briefs podcasts seminars and public lectures in order to ensure the maximum possible dissemination of the results the project will be hosted at leiden university
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twinning to develop eltes research and innovation capacity in quantum reservoir computing
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quests primary goal is to amplify the scientific prowess and innovative capabilities of eötvös lornd tudomnyegyetem elte alongside its esteemed twinning partners linköpings universitet loughborough university aalto university justinmind sl and intelligentsia consultants sarl they collectively aim to create a quantum reservoir computing qrc system leveraging silicon carbide sic defect qubits over three years quest plans to roll out a research and innovation strategy centered on five core objectives each associated with eight interrelated work packagesobjective 1 is geared towards pioneering research to construct a qrc system based on sic defect qubits this avantgarde technology could potentially enhance computational speed and diminish power usage by over 100 times compared to traditional machine learning modelsobjective 2 emphasizes knowledgesharing between eltes seasoned researchers and the twinning partners facilitated via shortterm staff exchanges seminars and training sessions all complementing the research from objective 1objective 3 focuses on nurturing the career aspirations of earlystage researchers associated with both elte and the twinning entities they propose strategies like brief and intermediate exchanges workshops summer training sessions and a collaborative phd schemeobjective 4 aims to refine eltes administrative and managerial proficiency for european rd initiatives specifically this entails enhancing the expertise of eltes education support office and research support office in aspects like project management proposal drafting intellectual property management and scientific communication concerning european rd funding programmesobjective 5 is dedicated to bolstering the research stature and academic credibility of elte and its twinning counterparts this will be achieved through extensive communication outreach and dissemination efforts
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fuelling the future advancements in trifunctional catalysts for renewable biofuel synthesis
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the adventurous project harmonizes with the european green deals 2030 climate targets and the broader eu ambition of reaching carbon neutrality by 2050 it is firmly rooted in the pursuit of catalytic trifunctional systems for the transformative synthesis of sustainable advanced fuels saf derived from renewable feedstocks the crux of this endeavour rests upon the innovation of two core facets the integration of catalysts that can seamlessly host diverse catalytic sites and the genesis of an entirely novel synthetic avenue for the production of sustainable aviation fuels saf this project sets forth on a path towards sustainable development poised to chart a course marked by a nearzero emission co2 cycleadventurous leverages the expertise of dr camilla maria cova in organic synthesis and green synthesis complemented under the supervision of prof svetlana ivanova with broad experience in multifunctional heterogeneous catalysis at the university of seville use the fruit of this necessary collaboration will be the advanced design and application of a multifunctional catalyst able to revolutionize the biofuel synthesis what is more advanced technologies such as ultrasoundassisted reactions will be tested for an environmentally sustainable catalyst production and the success of the project will opens a completely new pathways not only to saf production but also to a numerous starting molecules for fine chemical synthesisadventurous is aligned with the msca green charter emphasizing environmental responsibility and sustainable development by developing sustainable biofuels and innovative catalysts it contributes to achieving the objectives of decarbonization energy efficiency and increased use of renewable energy sources in the transportation sector moreover it addresses key challenges of the current energy landscape as supply scarcity and environmental pollution by exploring alternative and renewable pathways for fuel production
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secure automated unified framework for exchange
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although the european unions disinformation policy has significantly developed since 2015 russias war in ukraine has reminded us all of the urgent need to stay ahead of the curve in order to fortify our resilience against the everevolving threat of foreign information manipulation and interference fimi in the last year russias strategic use of fimi in its war of aggression against ukraine has brought an unprecedented response by those defenders who seek to safeguard universal values democracy and freedoms by exposing russias efforts to manipulate global discourses while governance law protocols data exchange and forensic practices should converge to address fimi they currently remain disparate and unaligned this fragmented approach creates a significant hurdle in the fight against fimi hindering the ability of member states to prosecute ban attribute or sanction fimi actors or campaigns originating from state and nonstate actors to overcome this hurdle there is a need to better synchronise the interventions and harmonise our approach towards fimi as proven in the case of cyberattacks our consortium saufex secure automated unified framework for exchange comprises of concerned stakeholders who possess significant expertise and handson experience with the current systems and structures concerning fimi and are situated in the eus eastern regions where fimi incidents are frequently observed we strongly understand the importance of consolidating and utilising available information to establish a collective comprehension of fimi to achieve this our project proposes the creation of a fimi dataspace which we will herby refer to as a fimi knowledge database as well as the establishment of a resilience council to act as an intermediary between state and nonstate actors specifically regarding interventions and fimi attribution
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xr2esilience
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the health care system is in crisis and although the importance of nurses mental health is widely recognized achieving this goal is highly challenging promoting resilience in times of crisis appears to be a promising goal for public mental health innovative digital technologies to enhance resilience might contribute to a solution extended reality xr applications are highly immersive interactive and attractive to use the proposed project aims to leverage the potential of xr to promote resilience in nursing staff as resilience has a multitude of facets a prospective cohort study together with new analysis of existing large datasets will inform about those resilience factors that are the most promising target for interventions in nurses likewise barriers and facilitators of acceptance of resilience training in general and xrsupported interventions in particular will be extensively considered and researched within this project as acceptance through participation is a key success factor a xrsupported training to foster resilience will be developed in close cooperation with nurses and other stakeholders the proposed xr2esilience solution consists of a flexible selection of xr modules that can be customised to meet individual nurse needs the efficacy of xr2esilience on stress coping and resilience will be investigated in a randomised controlled trial including a health economic evaluation in addition the project will go beyond the individual perspective and consider organisational and structural challenges the cohort study will enable to identify working environments where nurses can grow and enfold their resilience based on the results will develop a set of recommendations and checklists for employers and policymakers that support them in making nursing facilities resilience friendly places xr2esilience outlines a strategy for building resilience and the role of xr in resilience training
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development of novel desaturative strategies for the preparation of aniline building blocks via photoredoxcobalthat triple catalysis
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anilines and their derivatives are integral organic molecules with application as medicines agrochemicals and organic materials over the last 30 years the buchwaldhartwig and ullmann crosscouplings have dominated the area of aromatic amination these reactions involve palladium or coppercatalyzed cn bond formation between a halogenated aromatic and an amine only aromatics that have been halogenated will react with the metal catalysts and undergo crosscoupling therefore although these processes are widely used there are 2 significant challenges associated with them a aromatic halogenation reactions are often problematic in terms of selectivityb crosscoupling reactions are known to fail on complex and functionalized materials with this project we aim to provide a transformative advance in the field and demonstrate the direct conversion of functionalized ncyclohexylamides carbamates and sulfonamides into the corresponding naryl derivatives to achieve this we will use an unprecedented triple catalysis manifold based on photoredox catalysis cobalt catalysis and hatom transfer catalysis this innovative catalytic system will effectively trigger desaturation of the starting ncyclohexyl derivatives and key reactive intermediates this research will create a novel approach for the onestep synthesis of many complex anilines from unusual precursors which are largely commerciallyavailable or easy to prepare the proposal capitalizes on recent developments by the host group in aniline synthesis and dual photoredoxcobalt catalysisthe development of this innovative project at rwth aachen university will create new tools in bioorganic chemistry and enable the rapid and efficient preparation of highvalue materials implementation of the project will be facilitated by the generation transfer and dissemination of knowledge which will greatly enhance my future career prospects in accordance with the enviosioned training plan
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ordered nanoporous carbon architectures from biobased building blocks
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ordered nanoporous carbons are gaining appreciable interest in several green technology applications efficient charge storage metalfree carbocatalysis nevertheless at present they can only be fabricated using fossil fuelbased building blocks through energyintensive processes with large ecological footprint and with potential environmental pollution the overall aim of this project is to provide more sustainable alternatives to these fossil fuelderived materials by fabricating ordered nanoporous carbons from biobased constituents our project will focus on studying biobased polymerbiobased surfactant supramolecular assemblies objective 1 to develop a softtemplating system using only biobased building blocks objective 2 for obtaining various ordered nanoporous carbons objective 3 and apply them in charge storage systems supercapacitors objective 4 and for metalfree carbocatalysis advanced oxidation process objective 5 our goal is to have control on the nanoarchitecture and understand structureperformance relationships in applications in order to obtain cuttingedge highperformance materials for advanced devices our novel bottomup approach will give the first biobased softtemplating method to make ordered nanoporous carbons and is expected to open up new research directions for sustainable material solutions this project will provide materials and processes with reduced ecological footprint over existing products and technologies contributing to a sustainable economic growth and to the realisation of a resilient society
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data discovery platform with generalized exploratory management and search capabilities
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datagems is a data discovery platform with generalized exploratory management and search capabilities datagems is built on the principles of data fairness openness and reuse it aims to seamlessly integrate data sharing discovery and analysis into a system that addresses the whole data lifecycle ie sharing storing managing discovering analyzing and reusing data andor metadata bridging the gap between the data provider and the data consumer datagems is a nextgeneration data discovery and management ecosystem that engulfs different types of data structured unstructured realtime and historical and enables users to a enrich data through powerful data profiling mechanisms b seamlessly discover and analyze data across and within datasets using userintuitive discovery and analysis mechanisms such as using natural language and patterns and c effectively explore and combine data with the help of stepwise guidance mechanisms during dataset discovery and analysis the effective and efficient functioning of these mechansims will be powered by a data and model management layer that decouples data management at the low level from the data analytics at the higher level datagems is informed by and will be initially tested and deployed to promote data fairness and benefit diverse user communities and types of users on core domains education meteorology and language data infrastructures
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codesign of ecommerce lastmile delivery and return options with zero emissions
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codezero is a threeyear project aiming to cocreate sustainable and zeroemission lastmile delivery and return solution for ecommerce that are also attractive to consumers it is articulated in four phases an analysis phase which provides 1 an analysis of existing delivery and return options and an understanding of how they are shaped by the needs and constraints of all involved stakeholders 2 an indepth intersectional analysis of various groups of online consumers to understand what are the features of delivery and return options making them attractive with the aim to identify mechanisms to incentivize behaviour changes and 3 develops an assessment framework to measure the impacts in the environmental economic and social domains of new solutions a design phase in which codezero engages in a codesign process involving retailers transport operators consumers and local authorities in developing 1 guidelines for retailers to raise awareness among customers 2 a set of zeroemission and sustainable delivery and return options for retailers and transport operators and 3 a toolset for local authorities to accelerate the transition towards sustainable solutions in last mile consignments in ecommerce a test phase running 4 pilots in 4 different european cities in italy netherlands belgium and norway to test a set of sustainable solutions identified in the previous phase with the aim to prove their feasibility to finetune their design and to assess their impacts from the perspective of all stakeholders a consolidation phase where 1 codezero outcomes are finetuned based on the lessons learned from real life applications 2 requirements for upscaling of solutions at european level are discussed 3 recommendations are formulated and 4 directions for future research are outlined engagement with consumers and retailers associations industry stakeholders cities and researchers contributes to shaping its results
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next generation 1200v electric high voltage powertrain
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enlighten aims at developing integrating and testing a next generation post 800v electric vehicle powertrain with an indicative voltage level of 1200v it targets a higher performing cost optimized and more sustainable drivetrain layout that is also backwards compatible to the existing charging infrastructure with 1000v or 500v respectivelydetermining exactly how high the new voltage level should be to enable expected advantages in a systemic and systematic way is also part of the project a new voltage level affects the entire sphere of electric mobility both horizontally vehicle charging infrastructure users manufacturers and vertically oem tier1 tier2 single component supplier hence a deliberate decision is required to accomplish this an advanced electrical system architecture is presented by the enlighten consortium in this proposal on whose basis a specific electric vehicle drivetrain will finally be developed and demonstrated in a csegment vehicle the at trl5 delivered powertrain will consist of a dual voltage battery system and an integrated motorinverter edrive system complemented by an intermediate dcdc converter an ac and dc capable onboard charger and a power distribution all power electronic devices will exploit low loss ultrafast switching gallium nitride gan semiconductors for highest efficiency and to minimize cooling demand and component size the dual voltage battery can be switched dynamically from one battery voltage into the other while driving through these and other measures the enlighten system delivers significant advances over the 2024 state of the art the enlighten consortium includes 2 automotive companies 1 tier1 supplier and 2 smes their expertise is leveraged by the partnership with 2 research institutions and 4 academiauniversities constituting an ideal setup for strengthening the competitiveness of the european automotive industry
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the impact of the viral shunt and its metabolic landscape on microbial lifestyles and the flow of carbon during algal blooms
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the fate of carbon in marine environments is influenced by associations between heterotrophic bacteria and phytoplankton mediated by chemical communication and metabolic exchange deciphering the nature of these associations is critical given the impact of marine plankton on biogeochemical cycling and climate regulation viral infection is a prevalent mortality agent of algal blooms in the ocean leading to massive release of biomass to the dissolved organic matter dom pool one of the largest global inventories of carbon this process termed the viral shunt is a key ecosystem process but remains unquantifiable and mechanistically enigmatic furthermore the metabolic composition of the dom released following viral infection vdom and its role in shaping microbial communities are largely unknown in the vibes project we will disentangle the complexity of the viral shunt and elucidate its impact on microbial lifestyles mutualism and pathogenicity during algal bloom demise we will generate experimental approaches to study these bacterial lifestyles and uncover the chemical language that mediates them our expertise in marine microbial chemical ecology using singlecell transcriptomics to quantify hostpathogen interactions and metabolomics to identify the chemical signals that govern microbial interactions will pave the way for unprecedented quantification of the viral shunt we will investigate the molecular and metabolic basis of virusderived microbial lifestyles and their consequence for the flow of carbon in the ocean both under controlled labbased experiments and during complex interactions in the ocean we will investigate how microbial lifestyles that specialize on vdom can determine the partitioning of carbon between the dissolved and particulate fractions representing carbon cycling and export respectively ultimately vibes will enable to evaluate the importance of microscale interactions to the cycling of carbon in the ocean
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