prompt
stringlengths 3
262
| response
stringlengths 12
3.91k
|
|---|---|
graspos next generation research assessment to promote open science
|
graspos aims to build and operate a data infrastructure to support the policy reforms and pave the way towards a responsible research assessment system that embeds os practices and accelerates its adoption in europe graspos will focus on extending the eosc ecosystem with tools and services that will facilitate monitoring the use and uptake of various types of research services and outputs publications datasets software and will catalyse the implementation of policylevel rewards to foster os practices these tools and services will build upon multiple sources of metric data eg opencitations scholexplorer including capabilities offered by the eosc core that will be federated in the context of the project and will take into consideration both contemporary guidelines for responsible research assessment rra like those provided by initiatives like dora and the leiden manifesto and the suggestions from a diversity of relevant stakeholders graspos will also incorporate piloting activities to codesign showcase validate and evaluate grasposs key results considering domainspecific aspects and different levels of osaware rra such as the researcher individualgroup institution and national level
|
translating science into policy a multisectoral approach to adaptation and mitigation of adverse effects of vectorborne diseases environmental pollution and climate change on planetary health
|
planet4health provides new knowledge and tools on environment degradation and its impact on human animal and ecosystems health the project results will support policy making process and citizens awareness on sustainable planetary health climate and environmental policies and adaptation and mitigation strategies to natural hazards planet4health will develop collaborations from a large variety of organizations from the environmental and climate science public health epidemiology veterinary medicine social political and economic science engineering law and ethics and communication to produce solid knowledge and tools to facilitate learning and practice on the interaction between the natural system and human health four tailormade case studies will be performed 1 one health effects of vectorborne diseases 2 air pollution 3 food contamination arising from soil and water contamination 4 mental wellbeing linked to environmental and climate stressors in different geographical area thanks to the large project network that will draw universal conclusions and replicable solutions to improve the predictive capability and preparedness the consortium will produce research technological innovation tailored outreach and training and policy solutions through a crosssectorial multidisciplinary scientific collaboration in line with the transnational character of planetary health for these aims the project will a collect organize and assure open availability of new and already existing data on climate and environmental indicators linked to one health b carry out analyses on data and build innovative interoperable and multifunctional digital prototypes c produce new knowledge and tools to support one health policies by applying social science theories and involving citizens policymakers and stakeholders d offer openaccess data tools and research material to public authorities for decision making and academic research for further study
|
resilient multimodal freight transport network
|
remunet identifies and signals disruptive events and assesses their impact on multimodal transport corridors it reacts quickly and seamlessly upon disruptive events in realtime it supports tmsproviders to improve route planning resilience remunet communicates alternative predefined multimodal transport routes to logistics operators and subsequently to truck drivers locomotive drivers and barge captains through this it enables a faster and adaptive multimodal network response remunet orchestrates route utilization suggests transshipment points and optimizes capacity allocation minimizing damage and shortening the recovery time what is remunets core objectiveas trailblazer for the physical internet remunet pursues the vision to enable and incentivize synchromodal relaytransport on european rail road and inland waterways to increase the holistic network resilience it significantly reduces emissions and boosts freight transport corridor efficiency in case of disruptive events how will remunet achieve this1a standardized method to describe multimodal transport networks the proposed standard is derived from existing approaches and developed together with critical stakeholders to ensure europewide practicability and acceptance2an algorithm capable of calculating multimodal route alternatives and capacity utilization in the face of disruptive events it uses realtime data for dynamic synchromodal alternative route planning 3a collaborative platform connecting relevant freight operators and enables them to manage disruptions this is done by providing secure and resilient digital logistic and network management tools enabling alternative route planning information and orchestrating eventbased synchromodal relay transportation 4using reinforcement learning to model and evaluate alternative courses of action providing the basis for a selflearning adaptive multimodal european freight transport and logistics network
|
electrification of industrial processes using induction and microwaves technologies
|
joulia aims to develop two innovative electricheating processes to maximize their flexibility energy savings and res integration into two midtemperature manufacturing processes to this end induction and microwave technologies will be demonstrated in the rubber and plastic sector for rubber vulcanization rubber production and glue thermal activation multilayer pipes production respectively in this vein processes configuration will be optimised and monitored using the developed digital models and process simulations to finetune the whole industrial process enabling their control adaptability and cost optimization health and security requirements will be implemented supported by a predictive maintenance tool both contactless systems will be validated at trl7 including technical and economic studies tea and lcalcc using previously developed models additionally joulia solutions replicability potential will be assessed in other industrial sectors food and ceramics addressing future upscaling plans to be aligned with new market opportunities and stakeholder engagement general public awareness of electrified technologies will be improved while new business models and training materials will be developed joulia will contribute to decarbonizing a sector that heavily depends on fossil fuel combustion trying to maximize its energy efficiency sustainability and economic benefits improving european industries competitiveness and supporting their clean energy transition to achieve these objectives joulias consortium consists of 16 partners from 7 eu countries with diversified expertise and knowledge of the addressed processes and access to the required lab and pilot infrastructure at the end of the project joulia will increase the resilience and security of european industrial as well as minimize its dependence on imported fossil fuels
|
active region classification and flare forecasting
|
the sun is an enigmatic star that produces the most powerful explosive events in our solar system solar flares and coronal mass ejections studying these phenomena can provide a unique opportunity to develop a deeper understanding of fundamental processes on the sun and critically to better forecast space weather the active region classification and flare forecasting arcaff project will develop a beyond stateoftheart flare forecasting system utilising endtoend deep learning dl models to significantly improve upon traditional flare forecasting capabilities arcaff will increase the accuracy and timeliness of current operational flare forecast products and create new time series flare forecasts furthermore arcaff forecasts will include forecast uncertainties another major improvement over current systemsthe large amount of available spacebased solar observations are an ideal candidate for this type of analysis given dl effectiveness in modelling complex relationships dl has already been successfully developed and deployed in weather forecasting financial services and health care domains but has not been fully exploited in the solar physics domain solar flare forecasts from arcaff will be benchmarked against current systems using international community standards and will demonstrate arcaffs superior forecasting capabilities the datasets codes and dnns developed for arcaff will be made openly available to support further research efforts and encourage their reusearcaff is relevant to the work program as it will exploit currently available data space weather data to train dl models to improve forecast accuracy dl itself is an innovation enabling technology and analysis of the dl models will improve scientific understanding of solar flares through the creation of new forecast products it will develop and mature new concepts for both scientific and monitoring purposes following the bestpractices of meteorological services
|
the bioarchaeology of sociopolitical changes in amphipolis exploring the impact of broad historical trends and status quo transitions on human lifeways and deathways through a multiproxy approach
|
this project will develop a new interpretive model to reveal the extent to which multiple sociopolitical transitions representing different forms of urbanism affect human lifeways and deathways in a diachronic perspective this is achieved by implementing an interdisciplinary methodology combining archaeological and historical theory macroscopic bioarchaeological approaches and stable isotopes the diachronic case of amphipolis in northern greece experiencing many different political models between the late archaicclassical and roman periods is an ideal case study human skeletal remains from 300 inhumation and 100 cremation burials spanning between the 5th c bc to 1st c ad will be analyzed methods will include 1 studying funerary practices and deathways 2 investigating health and lifestyle and 3 exploring biodistance and human mobility i will also initiate an open access collaborative morphological biodistance database to create long term impacts on human mobility studies by moving to auth i will work closely with sevi triantaphyllou a topleader in funerary practices and osteoarchaeology her expertise along with resources and specialties of other distinguished staff members of school of history and archeology provide the perfect environment for the multidimensional contextual training necessary for the project and for my career metamorphosis a period of secondment is included at bblab vub with christophe snoeck an expert on isotopic geochemistry and a global pioneer on the topic of isotopic study of cremated human remains my career goal is to be a research leader in social bioarchaeology which this project will enable by developing an integrated method for the combined analysis of mortuary environment with lived experience through a multifaceted training in core skills along with supervision teaching and public outreach i will develop key resources to maximize the impact of my career advancement
|
artwork unique recognition and tracking through chemical encoded data miniaturized devices and blockchain alliance
|
artifacts are constantly threatened by anthropogenic actions looting smuggling and illicit trade of cultural goods pose major risks to our cultural goods and our cultural identity one of the major consequences of these illegal activities is the dissociation meaning the loss of information associated with an object such as provenance identification or location information without which the object loses significance or is lost thus art property marking and tracking are crucial to ensure the object identification collection management and protection while maintaining their state of conservation several actions have been adopted during the years to strengthen the protection of cultural property and cultural heritage but they often lack effectiveness the aurora project wants to fill this gap by demonstrating how chemical marking miniaturized device art deepscan technique cloud and blockchain based platforms can be combined to create a costeffective nondestructive and noninvasive countermeasure against illegal activities while preserving artifacts the technologies researched and implemented in aurora will converge in a digital tool allowing relevant stakeholders art dealers curators auction houses logistic services and enforcement agents to easily verify artwork authenticity and provenance enabling art piece movement tracking in close collaboration with relevant cultural institutions partners aurora will showcase real setting applications to validate the noninvasiveness low cost longterm stability confidentiality and data security features of the proposed solutions in parallel aurora will foster technological democratization among cultural institutions by creating a knowledge bridge between technical competencies and cultural heritage professionals specific awarenessraising activities will demonstrate how the aurora solutions can be a means to preserve cultural identities mixtures through cultural heritage preservation
|
an immunoassaybased point of care test kit for rapid inexpensive and effortless detection of urinary tract infections
|
urinary tract infection uti is the most common infectious disease seen in humans also uti ranks as the number 1 infection that leads to a prescription of antibiotics just in 2019 4046 million different uti cases emerged worldwide that costed tens of billions of euros to economies and caused around 236000 deaths luckily utis can be cured effectively with right treatment the problems need to be resolved are diagnosing of uti takes a long time 27 days requires expertise and is costly high false positive rates and contamination risk causes unnecessary laboratory costs and workload empirical treatment given without waiting for long culture results leads to unnecessary andor wrong antibiotic usage and consequently to antibiotic resistanceas nanomed diagnostic we developed an immunoassaybased point of care test kit for rapid inexpensive and effortless detection of utis rapid uti it can diagnose uti just in 5 minutes it provides at least 10 times less cost for diagnosis by eliminating several technical processes and costly equipment and consumable investments it eliminates all unnecessary laboratory costs and workload caused by falsepositives and contaminated samples it prevents unnecessary or wrong antibiotic usage and the bacteria to develop resistance to antibioticswithin the scope of the 12month planned project meetings will be held with european potential customers and distributors samples will be sent improvements will be made according to the feedback received certification studies will be completed product promotion will be made by participating in fairs exhibitions and conferences printed and digital marketing materials will be prepared and a clinical trial will be conducted in an eu origin institution
|
highprecision multileg higgs and top physics with finite fields
|
modern experiments at the large hadron collider will yield measurements of several important observables with percentlevel accuracy similarly accurate theoretical predictions are however needed for comparison with data unlocking its outstanding potential to test the standard model of fundamental interactions its symmetry braking mechanism and its limitations hence giving us important hints about new physics highprecision predictions in highenergy physics are however affected by high complexity this is currently preventing highprecision studies for crucial interactions such as multiparticle interactions involving the top quark and the higgs boson due to the presence of a large number of external particles and massive external and internal states at the core of these predictions is the perturbative calculation of scattering amplitudes which need to be computed at least at nexttonext to leading order to match the experimental uncertainty this task for multileg massive processes is beyond the capabilities of existing techniques and tools ffhiggstop aims to achieve a breakthrough in highprecision predictions for highenergy scattering processes involving many external particles and massive internal and external final states this will be achieved thanks to the development of new revolutionary methods for scattering amplitudes building on top of cuttingedge technology based on finite fields and functional reconstruction techniques its main objectives are 1 develop groundbreaking techniques for computing scattering amplitudes at higher orders in perturbation theory 2 perform new highprecision phenomenological predictions for top antitop pair production in association with an electroweak vector boson or a higgs boson ffhiggstop will unlock a range of new possibilities for studying fundamental interactions and develop new technology with a broad spectrum of possible applications in physics and other sciences
|
thermodynamicinspired computing with oscillatory neural networks
|
there is a pressing need to address the power consumption of computing which keeps rising to the point it has become an environmental concern despite the remarkable progress in semiconductor technology computing architectures are still energy inefficient engineered for deterministic tasks as well as susceptible to noise heat and variations instead of massively overdesigning architectures to compute with an acceptable degree of reliability this research aims to let physics do the computing and harness noise heat and variabilities for energy efficient computing at the heart of the proposed paradigm is the thermodynamics of open systems entwined with neuromorphic computing thermodon aims to develop an unconventional neuromorphic architecture to thermodynamically compute and selforganize learn i hypothesize that the natural thermodynamics of appropriately engineered architecture can harness noise heat and variations to selforganize toward energy efficient solutions to problems posed by external potentials i will develop such architecture with neuromorphic oscillatory neural networks that i master in my lab this research aims to address how thermodynamic principles can be applied to oscillatory neural networks to derive learning rules that are unsupervised continuously adapting and transforming the architecture into a dynamic selforganizing and open interactive system that learns infers and interacts with the environment thermodon will bring breakthrough innovations in thermodynamic computing models and aispecialized hardware to enable online training and inference to intelligent systems the interdisciplinary research in this project between neuromorphic computing and thermodynamics opens a new and exciting area in computer architecture triggering a paradigm shift in edge ai computing as well as an immediate impact as a hardware accelerator platform
|
preventing avoiding and mitigating environmental impacts of fishing gears and associated marine litter
|
nettag aims to provide a portfolio of three suitable innovative smart and sustainable solutions to address the negative impacts of fishing gears on marine life and habitats in line with the second issue of the call environmental impacts of fishing gears nettag will be based on synergistic activities between the fisheries industry scientists and ngos to develop three solutions to prevent avoid and mitigate the harmful impacts of fishing gears we will prevent marine litter derived from fisheries activities avoid loss of fishing gears and mitigate harmful impact by removing existing aldfg these three solutions will jointly contribute to reduce aldfg and marine pollution namely by reducing the introduction of hazardous chemicals and microplastics originated from aldfg reducing ghost fishing bycatch and entanglements of sensitive or endangered species on aldfg and improving mapping tracking and recovery technologies to retrieve aldfg nettag aims to upgrade and upscale the integrative preventive approach started in the previous nettag project and replicate it in mediterranean regions the three solutions will be developed to maturity trl 78 by the end of the project and will be tested validated and demonstrated in real conditions in atlantic and mediterranean countries namely portugal pt united kingdom uk spain sp italy it croatia hr and malta mt nettag ambition is to change the paradigm of the fisheries industry aspiring to transform the societal perspectives about the role of fishers as guardians and cleaners of the ocean nettag will empower the sector to take active actions to address marine pollution promoting their role as keyactors to tackle marine pollution and will will provide the fisheries industry with three smart and environmentallyfriendly solutions to reduce aldfg and prevent the environmental impacts of fishing gears
|
regulation of the larginine adma nitric oxide no pathway in the pulmonary vascular response to hypoxia and its role for survival of highrisk copd patients
|
no pressure will address the hypothesis that intermittent hypoxaemia is a major driver of the pulmonary pathophysiology and the systemic comorbidity that is present at a subclinical level already in early disease stages of a significant subgroup of copd patients with a high risk of rapidly declining lung function and poor prognosis the project has been conceptualized to achieve groundbreaking scientific insight into the role of intermittent hypoxaemia as a driver of copd progression and outcome via dysfunction of the larginineadmano pathway its five work packages will span from molecular regulation of the pulmonary larginineadmano pathway in hypoxia to cellular oxygen sensing and signal transduction mechanisms via translational studies in genetically modified mouse models and genotyped healthy humans to clinical proofofconcept studies of exerciseinduced intermittent hypoxaemia as a diagnostic indicator to identify a subgroup of highrisk copd patients and the ability to therapeutically intervene by pharmacological modification of the l arginineadmano pathwaycombining stateoftheart molecular biology techniques specifically designed genetically engineered animal models and translation of the obtained results into genomically characterized humans who will be exposed to hypoxia no pressure will achieve a unique level of depth in our understanding of the molecular pathophysiology of the lungs response to hypoxia with proven relevance to human biology beyond this no pressure will take the step towards validation of pathophysiologically proven biomarkers and thus molecular mechanisms in the worlds unique longterm prospective cohort for lung disease in addition it will deliver unequivocal evidence for clinical utility in two small but well defined copd patient cohorts with one having a focus on prognostic relevance and the other one opening the avenue towards future pharmacotherapeutic intervention to improve prognosis
|
twinsafe advancing road safety through twinning
|
the twinsafe project is dedicated to advancing road safety research capabilities at the university of zagrebs faculty of transport and traffic sciences ftts by collaborating with lund university lu and hasselt university hu the projects overarching goal is to establish ftts as a center of excellence in multidisciplinary road safety research education and innovation twinsafe aims to promote knowledge sharing best practices and a multidimensional approach including joint research capacity building internationalization diversity and entrepreneurial thinkingroad safety is a global concern with road accidents causing a substantial loss of life and severe injuries worldwide the eu has set ambitious targets to reduce road fatalities and injuries by 50 by 2030 emphasizing the safe system approach however disparities exist among eu member states including croatia where challenges persist despite highquality road infrastructure these challenges result from a lack of integration and interdisciplinary collaboration among stakeholderstwinsafe seeks to address these challenges by fostering cooperation with the newly established centre of excellence for road traffic safety certs certs aims to unify experts from academia industry and the public sector encouraging interdisciplinary collaboration to develop innovative solutions and align research with the safe system approachin summary the twinsafe projects mission is to elevate road safety research and innovation at ftts collaborate with leading european institutions and embrace an interdisciplinary approach through certs the ultimate objective is to make significant strides in addressing the critical issue of road safety and contribute to the eus ambitious targets for a safer road environment
|
precision medicine to prevent arrhythmic events in athletes
|
regular physical activity is known to be beneficial for health can prevent cardiovascular disease and reduce overall mortality however high intensity exercise can promote the development of arrhythmias and cause sudden cardiac death recently the profpeter schwartzs group discovered the phenomenon of exerciseinduced long qt syndrome exilqts affected athletes develop significant qt interval prolongation and repolarization abnormalities on the electrocardiogram during training periods and normalisation occurs during detraining clinically these athletes resemble patients with congenital lqts who are known to be severely at risk for lifethreatening arrhythmias but no pathogenic genetic variants in main genes responsible for lqts were found data on how exercise could trigger pathogenic qt prolongation and arrhythmias is limited and thus the possibilities to evaluate potential risks and prevent sudden cardiac death in these young athletes are currently absent this project will use a precision medicine approach to reveal molecular culprits of exilqts byidemonstrating that the disease could be recapitulated in vitro using athletespecific induced pluripotent stem cellderived cardiomyocytes modelsiicreating a statistical model integrating genetic electrophysiological and molecular dataiiidiscovering major factors responsible for exilqts development and identifying molecular targets for risk stratification and therapyresults of the study will shed the light on mysterious exerciserelated qt prolongation and will contribute to better risk assessment and clinical management of arrhythmias in young athletes
|
exploring plausible circular futures
|
circular economy ce represents a new paradigm that is capable of pushing the frontiers of sustainable development by transforming the relationships between ecological systems and economic activities such a new paradigm is expected to repair economysocietynature interactions replacing the current linear economic model with a new one that is restorative and regenerative by intention and designhowever while there is common agreement that the transition towards a ce could foster more sustainable futures there is a lack of discussion about how a truly circular economic system should be organised most of the current literature on ce fails to recognise this presenting the transition towards a ce as a straightforward neutral and apolitical process implicitly characterised by a technooptimistic and ecomodernist stance within this context this project calls for opening up a debate to deconstruct the increasingly hegemonic discourse of ce based on a technocratic approach and reconstruct it by embedding normative and political dimensions looking at a plurality of plausible ce futures and discussing their implications in terms of the organisation of production and distribution networks also involving a wide set of stakeholders as such the project will involve a plurality of disciplinary perspectives in order to devise future supply chain configurations that could be implemented in specific industrial sectors under specific ce scenarios a wide array of nonacademic beneficiaries ensures that the project will be capable of realising relevant knowledge transfer through secondment mechanisms
|
terahertz integral field unit with universal nanotechnology
|
the next challenge in millimetersubmillimeter mmsubmm astronomy is to generate 3d maps of statistically large cosmic volumes with complete spectral information to uncover the history of cold matter back to the first billion years of the universe the evolution of hot matter in galaxy clusters and the emergence of cosmic largescale structure from those baryonic materialsvital for this endeavor is the integral field unit ifu which is a 2d array of spectrometers that instantaneously measures the spectrum of all points in the image the ifu has reshaped astronomy at shorter visible wavelengths but it is totally absent for mmsubmm waves because it falls out of reach of any existing technologyhere i propose to revolutionize astronomy by developing a terahertz integral field unit with universal nanotechnology tifuun tifuun hosts mmsubmm ifus that each have up to 217 spectrometer pixels spaxels a wide instantaneous bandwidth up to 12 and a sufficiently high spectral resolving power up to r 1000 operating at photonnoise limited sensitivity the breakthrough is the integrated superconducting spectrometer iss technology which allows to miniaturize the entire ifu onto a commercial 150mm diameter silicon waferi will take tifuun to the aste 10m telescope with a set of sciencetailored ifus and perform groundbreaking observations in 1 ultrawideband spectroscopy of dusty starforming galaxies 2 unbiased mapping of highredshift lineemitting galaxies 3 lineintensity mapping of the cosmic largescale structure and 4 diagnosis of galaxy clusters using the sunyaevzeldovich effect i will make the tools for designing the ifu open source encouraging the astronomical community to propose science in combination with optimized ifu designs this costeffective openhardware concept marks a new paradigm that opens the specialized field of superconducting instrumentation to the world bridging cuttingedge nanotechnology and cosmology
|
everglass the new role of glass in a sustainable society technology for the integral recycling of glass
|
glass recycling uses mature technology limited by high energy consumption to melt tons of glass and the inflexibility of a heavyduty system current technology only allows the recycling of certain glasses and a very small amount of waste generated a new technology is required to allow the integral recycling of all types of glass drastically reducing the carbon footprint everglass proposes to develop a radically new technology called glass laser transformation for onsite glass recycling and the generation of customized or technical products users will feed waste into a new machine and select which new product to get the vision is ambitious as it aims to bring to the consumer market a novel technology to enable virtually infinite reuse of glass it is also radical since through a multipurpose system capable of being located on any site it proposes an alternative approach to the traditional centralized recycling process particularly where this model is not possible generating thousands of tons of glass waste annually taken to landfills the new technology goes beyond the current limitations of the systems high energy use expensive and rigid process strong logistical requirement adopting a highly environmentally friendly model that will allow flexibility in the use of the material and in the process therefore everglass has the potential to revolutionize recycling as a concept it also addresses one of the main problems with recycling user participation in an innovative way by allowing the personalization of recycled items of different use finally it aims to encourage the use and reuse of glass as a quality material displacing more environmentally problematic materials such as plastics this project brings together experts from advanced laser technologies uvigo glass and ceramics science icvcsic glass processing and engineering tnuad risk and impact assessment actalia social sciences esci and numerical simulation itwm
|
danubius implementation phase project danubiusip
|
danubiusip is a 36month coordination and support action to support the ongoing development of danubiusri an environmental research infrastructure linking rivers and seas as it proceeds towards its operational phase the project proposes 7 work packages in two parallel workstreams that together will deliver a new governance structure for the ri as it transitions to danubiuseric enhance the ict potential of the ri to enable virtual delivery of key services implement the science and innovation agenda supported by agile and quality assured scientific services demonstrate the value of the ri through examples of the unique services that the ri can offer to endusers across europe and internationally expand the danubiusri community and enhance its standing in the wider european and international environmental ri landscape and ensure that the potential of danubiusri to have significant social and economic impact is widely communicated danubiusip is coordinated by geoecomar romania and brings together 25 experienced partners from 14 countries from across europe in a consortium with complimentary areas of multidisciplinary expertise across the freshwater and marine research fields the project specifically seeks to address recommendations from the recent esfri and highlevel expert group reports on danubiusri and make a significant contribution to the expected outcomes and wider impacts of the horizon europe programme as such the project considers the importance of sustainability of financial commitments the need to test the funding model and to enhance the visibility of the ri danubiusip will further demonstrate the efficacy of an integrated and interdisciplinary approach embracing a riversea continuum perspective to fill current gaps in the research and innovation landscape to address key societal challenges in these environments impacted by anthropogenic pressures and climate change
|
politics institutions and production networks
|
what are the political sources and consequences of economic globalization and how do political institutions shape globalization current frameworks for understanding the politics over economic globalization emphasize a fragmentation of politics political conflict breaks down to individual firms and citizens because the gains from trade are concentrated on large globally engaged and politically active firms departing from this view pinpoint develops an innovative framework built on the linkages between firms created by domestic production networks production ties imply a much broader impact of economic globalization because many domestic firms interact with international markets indirectly as suppliers and as customers of globally engaged firms moreover these linkages vary in quantity and quality to date we know surprisingly little about the role of production networks in politics which creates a mismatch between the structure of modern economies and current theoretical frameworks ignoring such ties risks misattributing the impact of economic globalization overlooking economic roots of political coalitions and misunderstanding the sources and consequences of economic globalization pinpoint places economic exchange between firms front and center in an account of the behavior of governments firms and citizens in the context of international markets and of the role of institutions in such an account pinpoint will provide theoretical and empirical innovations that lead to a revised understanding of the political underpinnings of economic globalization and of the mechanisms through which institutions shape economic globalization
|
delivering the next generation of open integrated assessment models for netzero sustainable development
|
recent literature has underlined the interplay among climate mitigation adaptation and finance as well as between climate action and other development agendas including sustainable resource use human development and equity and environmental pressures such an interconnected policy environment requires an integrated ecosystem of disciplines methods and tools despite the significant evolution of integrated assessment models iams in the last decade there remain several criticisms on their design use and adequacy to respond to unaddressed and emerging questions in the light of the paris agreement and netzero ambition these include openness legitimacy and ownership as well as technical feasibility to represent demandside and broader societal transformations crosssectoral interactions physical impacts and adaptation climate finance and labour dynamics and other sustainability goals diamond will update upgrade and fully open six iams that are emblematic in scientific and policy processes improving their sectoral and technological detail spatiotemporal resolution and geographic granularity it will further enhance modelling capacity to assess the feasibility and desirability of pariscompliant mitigation pathways their interplay with adaptation circular economy and other sdgs their distributional and equity effects and their resilience to extremes as well as robust risk management and investment strategies this will be done via integration of tools and insights from psychology finance research behavioural and labour economics operational research and physical science we will develop a transdisciplinary scientific approach to legitimise the implementation process and cocreate research questions that stretch the frontiers of climate science as well as establish vibrant communities of practice to transparently open model enhancements and to develop capacities thereby lowering the entrance barriers to the established iam community
|
corticostriatal circuit assembly in fragile x syndrome
|
fragile x syndrome fxs is the most common inherited form of intellectual disability and the main monogenetic cause of autism spectrum disorder fxs is caused by the epigenetic inactivation of the fmr1 gene during the first trimester of gestation fmr1 encodes for the fragile x mental retardation protein fmrp which regulates the transport and translation of mrnas involved in brain development already at 6 months of age fxs infants display structural alterations in several brain areas including the frontostriatal circuit suggesting an altered neural network assembly during fetal brain development structural anomalies in the frontostriatal circuit may underlie symptoms that strongly impair the life of fxs patients such as attention deficit hyperactivity stereotypic language and motor behavior and problems with impulse controlthis project aims at understanding the causal factors of the altered assembly of the frontostriatal circuit in fxs fetuses to achieve this goal we will generate human cortical and striatal brain organoids from fxs naive induced pluripotent stem cells and assemble these organoids into corticostriatal assembloids the resulting in vitro model will be used to conduct research in two directions first it will allow us to recapitulate corticostriatal circuit assembly in fxs identifying potential defects in axon growth and guidance neuron morphology and neural connections second we will investigate the molecular causes of these defects in particular how the absence of fmrp affects the expression of proteins involved in the assembly of the fxs corticostriatal circuit these studies will make it possible for the first time to spatiotemporally follow the pathological events that cause fxs both at the cellular and at the molecular level and they will pave the way for the identification of new therapeutic strategies to prevent the development of the disease
|
antiprotonic atom xray spectroscopy
|
numerous experimental observations have shown that the standard model is not complete precision measurements in quantum systems are one of the privileged frontiers for searching for new physics as new particles may couple to atoms provoking tiny changes in atomic structure that can be measured with stateoftheart methods such searches are founded on an accurate understanding of quantum electrodynamics qed the field theory that describes the interaction between light and charged particles while qed is well understood for light systems like the hydrogen atom where agreement between theory and experiment have been achieved up to thirdorder interactions with the quantum vacuum for highz atoms in the strong coulomb field regime the theory remains untested beyond firstorder interactions this is due to both experimental complications and theoretical uncertainties linked to unknown nuclear properties i propose a new approach for testing strongfield qed via the xray spectroscopy of antiprotonic atoms in these systems orders of magnitude higher coulomb fields can be obtained acting like a magnifying glass for qed effects that become easier to measure using transitions between rydberg states uncertainties from nuclear properties can be avoided and two orders of magnitude sensitivity can be gained with respect to the best current experiments making testing strongfield qed finally possible for a broad range of atomic speciesthe realization of this project relies on the novel combination of two new technologies slow antiproton beams at cern and quantum sensing xray detectors the compatibility of these two requires new developments that will lead to a dedicated precision xray spectroscopy platform for antiprotonic atoms with transverse applications beyond qed in nuclear and new physics searches
|
enhancing digital preservation strategies at european and national level
|
eosc eden will develop and establish a framework to identify what data are candidates to longterm preservation based on use benefit and quality and a model for reappraisal points along data lifecycle and test usability it will identify practices to support the creation of curation longterm preservation and access strategies in europe these outputs will be complemented by a set of usercentric tools services and standards that the project will develop to support the establishment of a european distributed infrastructure for longterm preservation curation and access in europe namely eosc eden will build a registry to mainstream tools and services from trustworthy repositories and longterm archives into eosc will enhance and develop new services to automate preservation and curation actions and will identify standards and protocols to submit and exchange candidate packages for longterm preservation the development of the services will be enabled via use cases and disciplineoriented pilots the disciplineoriented pilots developed by the early adopters of the project meaning the representatives of the seven different disciplines directly part of the project will test the eosc eden outputs from a disciplineperspective ad will be key to inform the creation of a supportkit to guide and support new users in adopting the results of eosc eden to ensure adoption and longterm sustainability of the results eosc eden will engage and collaborate with different types of stakeholders one key player for the success of the project will be the horizoninfra2024eosc0103 awarded project last but not least eosc eden will work to boost data curation and quality practices in europe by creating awareness of the benefits and by enhancing skills in the area in particular the project will establish an expert curation network with a representation on organisation repository generalistspecialist collectioncatalogue and at digital object type level
|
origin evolution and function of bacterial extracellular vesicles in the human hostgut microbiome system
|
bacterial extracellular vesicles bevs are small membrane vesicles secreted by a diverse range of bacteria that act as bioactive nanocarriers of a high diversity of proteins lipids and nucleic acids bevs have mostly been studied in pathogenic bacterial models owing to their causal role in pathogenicity compared to other microbial features such as taxa genes or metabolites bevs secreted by the large diversity of commensal bacterial species of the human gut microbiota have received little attention so far leaving their influence upon gut microbial ecology and human health almost entirely unknown we hypothesize that gut bevs and their molecular cargos ie the gut bacterial vesiculome play critical roles in bacteriabacteria and hostmicrobiome interactions and in shaping phenotypes of hostmicrobiome systems our project will enable a comprehensive profiling of bev molecular diversity across a large number of gut bacterial taxa and a functional analysis of their impact on interspecies and interkingdom interactions we intend to tackle these objectives through three aims 1 characterize the origin diversity and evolution of the human gut bacterial vesiculome 2 investigate the role of bevs in promoting horizontal gene transfers among bacterial species in the gut microbiome and 3 investigate the role of bevs on bacteriabacteria and hostbacteria interactions we will tackle each of these aims from three diversity perspectives investigating multiple bacterial species including geographicallydistinct healthy human populations and comparing healthy vs disease the project will expand our basic understanding of the evolution and function of bacterial vesiculation it will also generate the first atlas of bev profiles across gut bacterial taxa and host cohorts providing key resources to mine for vesicular characteristics and functions that have translational potential for biomedicine
|
crescine increasing the international competitiveness of the film industry in small european markets
|
crescines mission is to increase the competitiveness of the film industry across small countries in europe and improve the circulation of films and av content coming from small markets internationally crescines aims to enhance the competitiveness and the cultural diversity of the european film industry this will be achieved by understanding engaging with empowering and ultimately transform european small markets setting out from research and piloting in 7 markets in their smallness these markets underline the challenges and drivers one must consider to increase the competitiveness of the eu film industry as all crescine will address systematically the whole film production distribution and consumption ecosystem the aim is to innovate at all levels of the value chain from policies to ways of data management and analytics production business models and modes of distribution crescine will develop novel tools methods and strategic approaches that all build on the concept of smallness and the positive affordances it entails for the overall competitiveness of the european film industry crescine will address all expected outcomes of the call through the lens of exemplary european small film markets which stand for the majority of film markets in the european union crescine will establish an innovative model of analysis and evidence collection across the value chain that is framed by cutting edge data analytical models comparative benchmarks promulgated in light of best available evidence including unprecedented data sources the findings will lead to work on innovative solutions and testing of new tools policies business models or financing schemes and green strategies these activities feed the overall impact of the project and its ability to produce new tools recommendations guidelines and exploit results that nurture the transformation of the film industry in small european markets and beyond
|
xray fluorescence imaging of metal complexes in hypoxic tumor spheroids
|
according to estimates from the world health organization who in 2019 cancer is the second leading cause of death after heart failure before the age of 70 the field of metalbased anticancer drugs has been on the rise ever since the discovery of the anticancer properties of cisplatin in 1965 which is in daily clinical use against various types of cancer many compounds failed to enter clinical studies since their anti cancer activity is mainly studied in two dimensional 2d monolayer cells which does not mimic the complex tumor micro environment in humans in the human body the cancer tumors grow in 3dimensional structure hence it is vital to study the anticancer activity of a drug molecules in the 3d tumors rather in 2d mono layer cells next tumor hypoxia 1 oxygen a situation where tumor cells are deprived of oxygen is a major challenge for oncology in this project we propose the synthesis of nheterocyclic carbene18naphthalicanhydride conjugated series of metal complexes gold rhodium iridium to study the anticancer activity and penetration depths in 3d tumor spheroids under hypoxia we also investigate the activation by reduction mechanism in presence of cellular thiols and cytotoxicity in vitro 3d cell spheroids and compare the results among the three metal centers the metal protein interactions play key role in many biological processes hence we also investigate the metalprotein interaction studies using capillary electrophoresis inductivelycoupled mass spectrometry at secondment we will investigate the structure activity relationship between metals and of related coordinating ligands in 3d spheroid under hypoxic conditions we mainly utilize xray fluorescence xrf imaging and synchrotron radiation to test the cellular localizations and penetration depth for the proposed metal complexes this project is expected to yield unique insights towards optimization of nextgeneration antitumor drugs
|
the ideosphere of the late ottoman arabic press mapping the discursive field of authors and texts through computational approaches
|
sihafa explores the late ottoman 1890s1918 arabic ideosphere of the eastern mediterranean through its periodical press sihafa transcends the individual periodical for a systematic and computational study of the periodical press as a discursive field and at scale in order to better understand both the intellectual history of the eastern mediterranean at a crucial historical juncture and periodical production itself as msca fellow dr grallert will receive crucial training at universitt hamburg and will scrutinise a digital corpus of seven arabic journals from baghdad beirut cairo and damascus with more than 7 million words the result of his current research through a combination of stylometric authorship attribution social network analysis and close reading of biobibliographical dictionaries he will evaluate theoretical and methodological approaches workflows and tools developed in the global north for their applicability to cultural heritage of the global south a secondment at uniwersytet jagielloski will provide methodological training in stylometry the research objectives are to 1 fill a gap in research by developing and evaluating methods for the study of arabic periodicals
|
fitness for active distribution networks in smart grids
|
fitness is a doctoral network at the intersection of electric power distribution networks optimization electricity markets communications and control systems the project will develop new methodologies for active distribution networks services in the era of smart grids fitness is the first training network dedicated to this challenge and involves 4 beneficiaries and 6 associated partners from 7 eu countries guaranteeing a paneuropean approach in a multisectoral context universities research centres and smes fitness will train a new generation of scientific professionals who can transition between disciplines and between the public and private sectors based on i recruited researcher rr projects ii courses and workshops with the emphasis on handson collaborative learning and attention to transferable skills iii mobility knowledge transfer all within a training network that includes some of europes finest researchers
|
modelling plating morphology in lithiumion batteries for enhanced safety
|
eu will aim to have at least 30 million zeroemission vehicles by 2030 primarily powered by the current energy storage technology of choice lithiumion batteries despite remarkable achievements in developing control strategies over recent decades many fundamental scientic issues underpinning the safety of these batteries remain elusive due to a lack of controloriented models for predicting the internal phenomena that can trigger internal short circuits and the consequent thermal runaway in this proposal we document a wholistic new physicsbased modelling approach which adequately incorporates a highly accurate description of battery electrochemistry as well as the accompanying subtle lithium plating phenomenon it will allow reliable prediction of the occurrence of safety accidents subject to battery operational conditions and the seamless integration into a safetyguaranteed battery management system as an mscapf fellow dr yicun huang will receive crucial training at the chalmers university of technology and engage in detailed battery modelling works which span the areas of computational materials and electrical engineering the interplay between the two areas will spark an innovative and productive throughput including 1 a multiphase electrochemical model under normal battery operations 2 a highfidelity materials model for the growth morphology of lithium plating and 3 controloriented models for battery safety assessment the result of this project will include a groundbreaking multiplemodel framework enabling fast and accurate battery safety state prediction and analysis a new interdisciplinary research product amalgamating materials modelling and control algorithms outreach and dissemination to crucial target audiences and a solid foundation for a safetyguaranteed battery management system intended to revolutionise electric vehicles
|
perpetuating stemness from singlecell analysis to mechanistic spatiotemporal models of neural stem cell dynamics
|
neural stem cell nsc populations in the vertebrate brain generate adultborn neurons for plasticity growth and repair neurogenic and gliogenic capacity based on longterm nsc maintenance functionally define stemness stemness embodies massive nsc heterogeneity at the single cell level and requires control of maintenance or differentiation decisions at the population level these features remain mechanistically unreconciled we hypothesise that spatiotemporal interactions among heterogeneous nscs are coordinated to control the population behaviour thus we propose a multidimensional project exploring these features in time and space to decode the mechanistic principles of stemness to this end we bring together experimental and theoretical groups with complementary expertise in nsc biology biostatistics and mathematical modelling in an iterative experimentalmathematical approach we will 1 solve the topology of individual nsc trajectories in transcriptomic space 2 identify local cellcell coordination mechanisms that impact these trajectories in situ and 3 decode the resulting systemic properties and outputs of nsc ensembles at longterm and large spatial scales this programme will result in original methods including retrospective transcriptomics in single cells innovative barcode transfers and a novel mathematical framework to describe structured spatiotemporal population dynamics we will focus on two biological model systems the adult mouse ventricular subventricular zone and zebrafish pallium where nsc ensembles display comparable heterogeneity but differ in spatial organisation and fate dynamics together peps will uncover the general principles and regulatory mechanisms of perpetuating stemness in time and space it will lay the conceptual and methodological foundation to manipulate stem cell systems to improve their stability or output and also produce new methods of universal value for studying cellular systems
|
smart and sustainable host univercities leveraging cityuniversity interactions to further the twin green and digital transition
|
sunset aims to develop innovative research and training capacity around cityuniversity interactions driving the eus green and digital transition this twin transition is a defining element of the current eu policy agenda towards achieving climate neutrality and sustainable growth the european commission considers cities to be frontrunners in this transition agenda but their transformational capacity and resilience crucially depends on the presence of agile and highperforming urban innovation ecosystems sunset brings together 1 prominent researchers working in diverse geographical and disciplinary settings at leading universities n6 with 2 partners n16 from city governments often participating in the cities mission to achieve climate neutrality by 2030 innovation companies research institutes and civil society organizations to analyze and foster the performance of these urban innovation ecosystems drawing on a purposeful range of interdisciplinary international and intersectoral exchanges the doctoral network will investigate whether and how universities can successfully become key drivers of the twin transition in cities via their role as innovation partners the implementation of campus living labs and as architects of decisionmaking in governance ecosystems through a tailored combination of networkwide training events and academic and nonacademic secondments the sunset doctoral network will train a new generation of researchers to become future urban innovation ecosystem leaders in the pursuit of the twin green and digital transition the findings will lead to practical guidelines regarding the design and implementation of living labs for university and city management tailored strategies to foster more inclusive and diverse urban ecosystems and diverse forms of scientific outreach and dissemination
|
debiasing the uncertainties of climate stabilization ensembles
|
mathematical models have become central tools in global environmental assessments to serve society well climate change stabilization assessments need to capture the uncertainties of the deep future be statistically sound and track nearterm disruptions up to now conceptual computational and data constraints have limited the quantification of uncertainties of climate stabilization pathways to a narrow set focused on the current century the statistical interpretation of scenarios generated by multimodel ensembles is problematic due to availability biases and model dependencies scenario plausibility assessments are scant simplified singleobjective decision criteria frameworks are used to translate decarbonization uncertainties into decision rules whose understanding is not validatedeunice aims to transform the methodological and experimental foundations of modelbased climate assessments through quantification and debiasing of uncertainties in climate stabilization pathways our approach is threefold construct consolidate and convert we first apply simulation and statistical methods for extending scenarios into the deep future beyond the current century and status quo quantifying and attributing deep uncertainties we consolidate model ensembles through machine learning and human ingenuity to eliminate statistical biases pin down nearterm correlates of longterm targets and identify early signals of scenario plausibility through prediction polls finally we use decisiontheoretic methods to convert modelgenerated maps of the future into resilient recommendations and experimentally test how to communicate them effectively by advancing the state of the art in mathematical modelling statistics and behavioural decisionmaking we strengthen the scientific basis of climate assessments such as those of the ipcc the approach and insights of eunice can be applied to other highstakes environmental social and technological evaluations
|
synchronization of physiological rhythms between musicians and audiences in live concerts
|
heartbeats and breathing rhythms are essential to life labbased research suggests that certain contextual and social factors can impact the interaction between these physiological rhythms during joint actions such as ensemble playing synchinconcert aims at a cuttingedge contribution to the study of physiological rhythms by investigating for the first time to our knowledge the influence between the cardiac and respiratory rhythms of musicians and audiences in live concerts synchinconcert will also investigate how these rhythms reflect the aesthetics of the concerts and are influenced by social and contextual components three research events will be held with the stavanger symphony orchestra sso and a full audience in a concert hall during these events video audio cardiac and respiratory data from selected musicians and audience members will be recorded as well as questionnaires evaluating their level of immersion in the music a strong interdisciplinary approach will be adopted by integrating insights methods and techniques from several disciplines ie music performance science psychology physiology computer science acoustic engineering and cognitive sciences results can significantly contribute to the study of joint actions by identifying ways in which physiological rhythms support social interactions the hosts ritmo centre of excellence in oslo casa paganini in genoa secondment and sso placement offer a unique opportunity to strengthen my expertise in music psychology and performance focused on sound and behavioral components of interpersonal interactions in small ensembles to that of music performance physiology in large orchestras supported by the outstanding track record of research excellence of the host organizations the extensive mentorship experiences of my supervisors and the new set of skills acquired this fellowship will enhance my prospects for positions of independent researcher within and outside academia
|
tracing connectivity via ceramic technology in riverine environment of the middle danube region during the ottoman period
|
danube aims to study cultural connectivity among potters in riverine environment of the middle danube region during the 16th17th centuries which is a phenomenon of central importance for an archaeological interpretation of cultural change in central europe initiated with the ottoman expansion this interdisciplinary study combines archaeological and scientific analyses of common pottery with an anthropological theory on technology and written sources of the ottoman period to reconstruct the ceramic production technology and means of knowledge transmission along the danubesavadrava rivers common pottery included in danube is part of six largely unstudied archaeological collections from serbia and croatia and this project aims to highlight existing potentials of the middle danube region for archaeological studies of the postmedieval period focusing on pottery consumed in riverine settlements after the ottoman conquest the project explores links between ceramic morphology technology and cultural connectivity danube is the first study of riverine connectivity in postmedieval archaeology of central europe although danube deals with a specific region it can be used as an exemplar for addressing broader crosscultural and methodological questions regarding the role of rivers for networks of knowledge exchange and connectivity in the context of largescale migrations military pressure and cultural change the project introduces the regionalscale approach to ceramic studies in the middle danube region and goes beyond ceramic morphology to explore human interactions along large rivers of central europe danube benefits from the applicants sound research experience crosscutting archaeological and scientific studies of ottoman ceramics in southeastern europe combined with the access to materials from riverine sites and the prospect for synergies and expertise at the university of tübingen
|
improving forest drought resilience through tree xylem ecophysiological mechanisms
|
trees play a major role in earths water and carbon cycles climate change puts trees under a growing threat of droughtinduced mortality this already happens in europe where summers are becoming hotter and drier and across global forest biomes due to their large size and long lifespan trees need time to adapt and migrate time they lack under the fast rate of global change on the other hand foersts are amog the most important ecosystems we simply cannot afford to loseloss of xylem hydraulic conductivity due to eruption of air bubbles is termed xylem embolism despite many years of studying tree responses to drought it is still debated whether xylem embolism actually kills trees simultaneous processes like carbon starvation leaf desiccation and heat damage make it harder to pinpoint the direct effects of drought on xylem enbolism further while the extent of embolism avoidance has been characterized in many tree species embolism tolerance has been rarely studied and recovery processes are mostly unknown finally a wide research gap exists between ecophysiological mechanisms at the tree scale and implications at the forest scale this research proposal portrays a clear roadmap to resolving the open questions in tree hydraulic mechanisms under drought and to integrating them at the forest scale increasing drought resilience in forests through ecophysiological mechanisms requires 1 insitu field measurements 2 controlled experiments to decipher tree mechanisms and 3 advanced modeling to upscale treelevel measurements into the forest scale and support future forest managementwe will combine novel techniques custommade microct field detection of xylem embolism and water potential spatial mass spectrometry imaging and more field measurements and manipulations on mature trees greenhouse experiments on diverse tree species and computational modeling to test new hypotheses aimed at increasing drought resilience of forests
|
pathways towards carbon neutrality for climate environment health and socioeconomic cobenefits pantheon
|
pathways towards carbon neutrality for climate environment health and socioeconomic cobenefits pantheon offers a participatory integrated modeling approach developed via an iterative colearning process among researchers private and public stakeholders to assess how different mature and future trl4 technologies in crucial economic and energy sectors can be morphed into successful economically socially and environmentally sustainable joint decarbonization pathways the kernel of the project is a twotier innovative integrated assessment modelling framework that reconciles i goals for improving energy efficiencies decarbonization along the supply chain with ii socioeconomic impacts and challenges including health and labour and iii insights from informed stakeholders deliberations on a granular level nationalregionalsectoralfirm public stakeholders and stakeholders from sectors along the global supply chain
|
open science impact pathways
|
pathos aims to identify and quantify the key impact pathways of open science relating to the research system and its interrelations with economic and societal actors pathos will enable a new understanding of os impacts and their causal mechanisms through its workplan encompassing actions to synthesise and structure current evidence development of new methods and tools for measuring impact iterative pilottesting via indepth case studies innovative dissemination and networking and cocreation synthesis activities culminating in policy recommendations this is pivotal in order to develop effective os policy in the eu it will do so by collecting concrete evidence of the causal effects of os by studying the pathways of os practices from input to output outcome and impact including the consideration of enabling factors and key barriers impacts and pathways will be developed in particular in the three areas of science society and economy by investigating measuring and comparing its costs and benefits together with its pathways pathos will i bring a better understanding of the implications of open science for science economy and society ii provide recommendations to policy makers and other actors in the ri ecosystem as to how and to what extent open science should be promoted in a balanced way and iii develop innovative tools and methods using a big data to augment traditional ones for studying the causal effects of open science this will enable evidencebased open science policy prioritisation maximum os impact and increased ri capacity in eu research systems
|
interventions to promote mental and physical health in changing working environments due to climate change sustainable work practices and in green jobs
|
work environments are rapidly changing in europe the covid19 pandemic resulted in an acceleration of a range of complex and multidimensional trends at the workplace there is also increasing awareness of the importance of mental and physical health of workers and fundamental interconnections of work health and wellbeing climate change is further shaping the future of work on an unprecedented scale european economies are undergoing transformation and reorientation towards sustainability the european green deal is reforming the workplace through implementation of new sustainable work practices and policies circular economy solutions and rapid expansion of work in green jobs resulting in novel workplace exposures with likely impacts on health increases in complex algorithmic management and performance monitoring are also taking place with a view towards sustainability there have been calls towards inclusive green economies ensuring social protection and the creation of decent green jobs the overall objective of the intercambio project is to promote mental and physical health of workers in changing work environments due to climate change implementation of new working practices and among workers in green jobs we will examine key research questions regarding mental and physical health of workers and conduct detailed evaluation of interventions in strategic industries in europe relevant to green and digital transitions including in outdoor construction health care public transit renewable energy wind turbine and waste managementrecycling using a variety of multidisciplinary and stateoftheart research methods we will leverage large geographically diverse longitudinal cohort consortia for new climaterelated studies promote a framework for social protection and engage multilevel stakeholders findings are expected to have major scientific and societal relevance and will provide support for new policy action in occupational health
|
european researchers night in sweden 20242025 forskarfredag 20242025
|
forskarfredag researchers friday is swedens most widely dispersed science festival forskarfredag 2024 and 2025 ff202425 will consist of events arranged in 26 cities and an online programme open to anyone in total ff202425 will engage around 53600 attendees and 1150 researchersthe nonprofit association va public science has coordinated ff annually since 2006 ff202425 builds on previous years drawing on experience contacts and an everincreasing profile the ff motto is researchers are ordinary people with extraordinary jobsat ff202425 members of the public will meet researchers and participate in activities designed to stimulate dialogue and show that research is exciting and relevant to everyday life debates science cafes competitions shows experiments and handson activities common themes around eu priorities will inspire activities exploring the role of research in tackling societal challenges a collaboration with 7 other ern projects will deliver a set of europeanwide activities highlighting the european dimension of researchyoung people aged 619 are a key target group a school programme will offer numerous opportunities for encounters with research the borrow a researcher concept will enable 15000 pupils across sweden to meet a researcher in school or virtually as a researcher at schools initiative annual national mass experiments citizen science projects inviting pupils to work with researchers will involve appr 3000 peoplelocal events physical and some digital expected to reach around 35600 attendees will be organised by 10 partners and 18 external partners each event builds on local strengths and networks to give the highest possible impact all event organisers share experiences in a national network va is responsible for the coordination quality assurance common activities national identity awareness campaign and impact assessment of ff2425
|
fast brillouin microscopy for phase transition
|
multiple human diseases ranging from neurodegenerative disorders such as alzheimers disease to cancer have been found to be linked with biomolecular mechanical properties change phase transitions pts while these diseases have impacted many human beings 50 million for only ad the causes of most of these diseases are still mysterious and there is yet no effective treatment to understand the pathological role of pts and their corresponding potential as a therapeutic target for these diseases it is crucial to probe the mechanical properties of live cells current standard approaches to measuring the mechanical properties have important limitations requirement of contact force atomic force microscopy and optical coherence elastography and lack of cellular resolution ultrasound and magnetic resonance imaging an emerging tool brillouin microscopy bm provides the capability of imaging the mechanical properties through probing the socalled brillouin scattering spectrum in a noninvasive manner with 3d subcellular resolution its advent has led to a wide range of biological applications however the acquisition time for a standard confocal microscope size image is in the order of tens of minutes owing to the tradeoff between the measurement speed and the spectral resolution thus it prevents the bms from studying the kinetics of phase transitions in live cells fabrication is to substantially investigate invivo brillouin microscopy pushing the acquisition time to a submillisecond scale per spectrum while maintaining the high spectral resolution therefore permitting the measurements of the dynamic changes in mechanical properties of the living cells and tissues in subcellular resolution it will enable direct observations of biomolecular phase transitions and reveal their relationship with the pathological effects in cells the project will advance the research in understanding biomolecular pts thus bringing economic and societal benefits
|
towards reliable and safe gfr
|
gascooled fast reactor gfr is considered as one of the six most promising advanced nuclear reactor technologies supported worldwide by the generation iv international forum and esnii in europe with concepts under development in europe and the usa it excels in versatility combining very high core outlet temperatures and the possibility to close the fuel cycle allowing for very efficient and sustainable electricity and industrial heat production replacing burning fossil fuels the treasure proposal presents a research and innovation action aiming at connecting european developers of gfr demonstrator allegro v4g4 centre of excellence with expert organizations with experience in gfr and htr research who will utilize their unique expertise and knowledge and bring fresh ideas to the gfr development it is divided into 6 work packages four of them dealing with open research and development problems of gfrs namely the core operation and safety optimization wp1 experimental validation of the dhr concept wp2 gfr as industrial heat and power source wp3 enhancing gfr safety wp4 dissemination and outreach activities are included in wp5 alongside with communication activities with regulators and relevant international organizations and education and training activities wp6 ensures smooth management and execution of the projectthe main objectives of the treasure project arefurther optimization of the gfr fuel design and fuel cycleexploring possibilities to further reduce produced waste and to further enhance proliferation resistance in gfrsallegro safety concept demonstration including largescale experimental verificationoptimization of operation flexibility and performance of gfrs using intermediate heat storage system cogeneration and hydrogen productionfurther enhancing allegro safety via use of passive and redundant safety systemsattracting students and young professionals to work on gfr development
|
adaptive digital systems for sustainable construction and material management in the circular economy
|
adapt4ce is an innovative initiative aimed at revolutionizing the construction sectors approach to sustainability and resource efficiency the project focuses on sustainable deconstruction and material reuse through advanced digital technologies such as artificial intelligence machine learning augmented reality additive manufacturing am blockchain and the internet of things a primary goal of adapt4ce is to create expert systems for precise material characterization to improve traceability with rfid technology and to establish localized material banks for effective resource reuse by developing digital tools for informed deconstruction decisionmaking the project seeks to implement circular economy principles optimize the use of resources and ensure environmental sustainability in construction practices key activities include the development of computational algorithms for structural optimization integration of design for disassembly principles into building information modeling tools and the conduction of life cycle assessments for construction materials to promote sustainable design practices and reduce environmental impacts the project exploits advanced am techniques to enhance the adaptability durability and sustainability of construction materials by identifying smart materials with selfhealing properties and furthering the capabilities of 3d4d printing technologies adapt4ce aims to transform the industry standards and benchmark new manufacturing methods against traditional practices a centralized digital platform is being developed to integrate bim databases and digital tools to support the entire lifecycle management of construction projects this platform will facilitate predictive maintenance through digital twin technology ensure dynamic adaptation to changing conditions and enable stakeholder engagement with advanced data management and analysis tools
|
metabolomics investigation of cystic fibrosis pulmonary exacerbations
|
cystic fibrosis cf is a lethal genetic disease affecting 1 out of 2500 newborns in cf patients compromised innate immunity enhances the susceptibility to colonization of lower airways by different microbes leading to longterm bacterial infections data suggests that the resulting hostpathogen interactions can shape the course of disease progression but this relationship is still poorly understood i propose to use cf patients samples of exhaled breath condensate to investigate intramicrobial interactions and hostresponses especially during pulmonary exacerbations pex which are recurrent episodes of acute worsening of respiratory symptoms adversely influencing patients quality of lifemetabolomics ie the exploration of small molecules within a biological system under defined conditions has been acknowledged to be the omics discipline closest to the actual phenotype thus i plan to use an unbiased metabolomics approach based on liquid chromatographymass spectrometry to investigate the chemical environment of cf lungs with the aim of reducing interpatient variability characteristic of cf to increase the generalisability of the findings i will combine this approach with clinical information and cell biology techniques to test the immune response modulation in vitro and shed light on the important roles played by metabolites present in cf airways in the regulation of host immune responsestargeting the main hurdles in finding a cure for cf patients namely the interpatient variability and the elucidation of the immunopathogenesis of cf the expected results will give a necessary contribution to the understanding of cf mechanisms that are still largely unknown this knowledge is in turn fundamental to guide personalised clinical decisions for early intervention and amelioration of pex treatment to the best of our knowledge there are not yet studies proposing a similar methodology to achieve such an ambitious goal
|
the hidden weapon blockade in the era of the two world wars
|
the main aim of blockade is to investigate how blockades shaped the course outcome and aftermath of the world wars in both wars belligerents sought to blockade their enemies cutting them off from vital resources such as food oil information and capital to hasten their defeat existing research is contradictory and fragmentary leaving us in the dark as to the scope and the effects of blockades just as the world is confronted with new blockadesour hypothesis is that understanding the blockades is critical to the era of the world wars ca 19001960 the blockades affected societies the world over testing their resilience and vulnerability they produced new forms of violence and humanitarian care prompted innovation and learning and had integrative and disintegrative effects on wartime societies alliances and the world order the projects ambitious approach transcends the traditional fixation on western europe and integrates actors long seen as peripheral it connects the disparate histories of the first and second world wars in a single explanatory frame by uncovering the shared generational experiences and learning processes related to blockades allowing us to assess their impact on the wars and the peace that followed them the high gain promised by this project comes with the high risk that we might fail to separate the impact of blockades from other effects of warfare but it is a risk we believe we can mitigate via innovative methodology and careful source analysis blockade requires input from a range of academic disciplines economics and economic history international history cultural and war studies statistical and digital analysis and many languages only the synergy resulting from combining the four pi and the larger teams different qualifications and research methodologies will realise the potential for high scientific gains with the necessary complexity and range
|
linking infectious disease frontliners control efforts with central public health authorities in the african great lakes region
|
the african great lakes region is one of the most densely populated areas in africa and also one of the areas globally with the highest biodiversity and forced or voluntary migrations very limited information is available on the prevalence and epidemiology of infectious diseases especially gastrointestinal diseases and antimicrobial resistance that has been very understudiedlogistically it is difficult to sample and conventionally study infectious diseases in the area and such studies have limited realtime value locally in this study we will take full advantage of the potential offered by combining fielddeployable nanopore sequencing combined with metagenomics and laptop bioinformatics to establish frontline sequencing at remote sites and linking this with central sharing of analytic output newly developed bioinformatics solutions by us have made it possible to perform simple bioinformatics analyses in realtime using laptops and subsequently share the analytic output simply using the mobile net avoiding the need of transferring large amounts of data and access to highperformance computingin greatlife we will establish sequencing across six countries in the region and use this to study the abundances of amr in villages and refugee camps linking this with spatial and temporal epidemiological data will enable us to identify locally relevant drivers for amr and provide data for changing empiric treatment and policies in addition we will utilize sequencing directly on gi samples to identify the causative agents and their amr both to provide data for policies but also to provide immediate results for direct patient care in the frontline we will educate a number of people in the very frontline to utilize fieldsequencing and bioinformatics as well as more advanced bioinformaticians and epidemiologist centrally the data generated will be linked in realtime through a central hub in tanzania to public health authorities for actions
|
maximising impact of prescription drugs in rheumatoid arthritis
|
the squeeze consortium comprehensively addressed how biomarkers can be used to optimize disease modifying antirheumatic drugs dmards for rheumatoid arthritis ra ra is a chronic immunemediated disease with enormous healthrelated quality of life and socioeconomic impact a broad choice of dmards with different targets is up to date available in clinical care however without sufficient markers indicating the best choice for a particular patient treatment strategies can be ineffective cumbersome and expensive the team of leading academic centres with a firstclass record in translational and clinical research together with patients and small and medium sized enterprises smes has set out to deliver a collaborative programme to advance the clinical application of biomarkers to improve benefit safety and value of approved dmards squeeze utilizes models from data science clinical trials translational science and behavioural science to engage in a complementary synergistic and nonoverlapping manner addressing the use of biomarkers to improve the ability to select the dmard with the highest likelihood of fitting the immunophenotypic and clinical profile of the patient to optimise dose and route of existing dmards and to inform an innovative model of care focusing on patients preferences and needs to increase adherence to prescribed drugs through nine dedicated work packages squeeze integrates to validate clinical laboratory molecular digital and behavioural biomarkers to enable the recognition of patients with high likelihood of response to treatment and the selection of the drug with highest chance of benefit for an individual patient and as such improve efficacy and safety of existing therapies by squeezing the most out of existing drugs in synergy with other euwide activities
|
lh2 storage and fuelsystem below deck integrated in a service operating vessel
|
to achieve the ambitious objectives set at the international level the transition to an alternate low carbon energy source will become essential since batteries are limited to smaller ship and syntheticfuel will remain hardly available hydrogen will irremediably appear as the best alternative energy however the related challenge is to store efficiently and safely hydrogen and here liquid hydrogen lh2 is the most attractive solution alternate storage solutions ch2 ammonia have lower powertovolume ratio and additional constraints such as highpressure toxicity reverse transformation etc moreover lh2 is already becoming a standard in space aeronautics motorsport trucks navhys aims at providing a concept based on a lh2 storage and fuelsystem below deck integrated in a service operating vessel to provide to wind energy providers a fully decarbonized solution the design of the lh2 system its integration in the ship and the risk analysis will be very challenging as they deviate from previous prescriptive safety rules and design guidelinesnavhys will design a fuelsystem to supply gh2 at 5 bartambiant to be used in any propulsion system to produce from 500kw to 2mw this system will integrate a lh2 pump benefiting from arianegroups experience in ariane 6 thus making it more robust to sloshing and allowing beneficial impact of lowpressure tank considering sizing and loading limit a prototype of the distribution system will be tested on arianegroup test benchnavhys will confirm the safety and the operability of the proposed design with an approval in principle delivered by the classification company bureau veritasnavhys will address refuelling operations and supply chain evaluation based on the horizon europe delhyvehr project which already aims at demonstrating the capacity to refuel lh2 with a high flowratenavhys will also integrate an analysis of the potential scaleup of the system and a spillover towards other applications
|
intentdriven native ai architecture supporting computenetwork abstraction and sensing at the deep edge
|
the 6g smart networks of the future will provide the highperformance and energyefficient infrastructure on which next generation internet and other services can be developed and deployed 6g will foster an industry revolution and digital transformation and will accelerate the building of smart societies leading to qualityoflife improvements facilitating autonomous systems haptic communication and smart healthcare to achieve the aforementioned objectives in a sustainable way it is well understood that new approaches are needed in the way the telco infrastructures are architected federated and orchestrated these new approaches call for multistakeholder ecosystems that promote synergies among mnos and owners of all kinds or computational and networking resources that will share the extraordinary costs of yet another generation upgrade from 5g to 6g while facilitating new business models it is clear that the new architecture paradigms bring unprecedented complexity due to the sheer scale and heterogeneity of the orchestration domains involved that should be matched by equally capable automation capabilities thus 6g is aiming for the holy grail of pervasive aidriven intelligence termed as native ai however the multistakeholder infrastructures foreseen in 6g as per the network of networks concept will add a level of unprecedented management complexity due to the sheer scale and heterogeneity of the orchestration domains involved 6gintense aims to abstract and federate all kinds of computational and communication resources under an internetscale framework that is governed by an intelligent orchestration paradigm termed as dimo
|
investigation of biological seal whiskers to create artificial whisker sensors for underwater robots
|
marine animals employ diverse and fascinating flow sensing phenomena by exploiting the ambient complex fluid mechanics to track prey and escape from predators seals are known for their remarkable longdistance preyhunting capabilities owing to their whiskers which serve as ultrasensitive flow sensors for eg a seal is able to detect a fish swimming 180m away by following its vortex streets while the unprecedented tracking abilities of seals and the role played by seal whiskers in reducing vortexinduced vibrations have been conclusively demonstrated in past the fundamental mechanisms behind such pinpoint tracking remain unclear the geometrically intricate shape of the seals whiskers is believed to maximize their signaltonoise ratio to generate high sensitivity to the tiniest hydrodynamic trails in this project we propose investigations of the seal whisker behaviour both in live seals and in controlled lab experiments to shed new light on the fundamental mechanisms that enable the seal to display its excellent preytracking behaviour in particular how the seal effectively utilizes the spatial distribution of the whisker array on its muzzle to conduct multipoint flow measurements to track and locate its prey is unknown and of great significance we propose to study the morphological mechanical and material properties of whiskers to explain the exquisite sensing capabilities of seals and further use this understanding to develop biomimetic flow sensors for underwater robot navigation miniaturized and selfpowered micronano electromechanical systems memsnems strain and flow sensors will be developed for experimental animal studies and to develop artificial 3d printed mems whisker sensors and muzzles for experimental fluidstructure interaction studies an artificial seal muzzle with mechanosensory mems whiskers will be applied on underwater robots to create artificial vision and energyefficient maneuvering through fishlike schooling
|
quantitative multimodal pulseandlabel timeresolved chromatin maps
|
chromatin packages the eukaryotic genome in a highly dynamic fashion with dramatic structural changes during every cell cycle at the same time chromatin provides remarkable stability for transcriptional regulation and genome organization for example in maintaining gene expression programs and lineage identity during complex organismal development a mechanism to propagate information through disruptive transitions in the cell cycle namely dna replication and mitosis is key in maintaining heritable socalled epigenetic chromatin statesproteins that build and interact with chromatin foremost histones are much more than static architectural components this motivates the development of timeresolved quantitative assays in the living cell which will allow to capture dynamic features of chromatin states over timescales from minutes to days building on a synthetic biology toolbox a quantitative multimodal pulseandlabel strategy will be developed following protein populations in both time and subcellulargenomic space dynamic proteinprotein interaction networks and chromatin maps will be capturedthe project will use to stateoftheart quantitative biochemical imaging genomics and proteomics readouts including singlecell readouts these will feed into mathematical models to describe the dynamics and potential heterogeneitystochasticity of the system under study predict its response to perturbations and guide mechanistic hypotheses the project will systematically decipher mechanisms for propagating epigenetic chromatin states starting with the fundamental rules of histone inheritance through replication and mitosis additional levels of complexity introduced through chromatin remodeling activities nucleosome turnover and histone exchange will be integrated finally the dynamics underlying developmental chromatin state transitions including asymmetric cell fate decisions will be resolved
|
evolutionary government origins and consequences of structural change in government
|
why do government structures change traditionally the answer refers to political parties exercising control over a state bureaucracy yet government structures have been changing ever since they emerged alongside the modern state and thus already before parties existed the recent decline of party government worldwide also begs the question whether other actors and mechanisms matter that have been underestimated so far meanwhile it became a truism that structure shapes policy but existing research focuses on other effects of structural change in government such as democratic and economic outcomes or cabinet governance we lack systematic analyses of how structural change affects government policyto address these gaps statedna studies the change of units inside ministries and agencies as the building blocks of the modern state it submits a novel theory of evolutionary government that regards structural change in government as an interplay between a units structural features and its organizational and environmental environment this notion of multiple levels allows to study more than partycentric causes of change and for the first time to analyze the effects on government policy explicitly as evolutionary consequences managed by distinct unitsstatedna breaks new ground by applying genetic measures to assess structural change in government establishing the most comprehensive data set which begins with the primordial soup of the early 19th century when government structures fragmented 150000 units six countries 18152025 for the empirical analyses existing historical data on legislative activity organizational and environmental features will be used and extended statedna will exploit methodological advancements in biology such as data assimilation techniques to analyze the origins and consequences of structural change in government and to forecast such change thereby injecting a predictive notion into government studies
|
lipid droplets and phytovirus infection
|
the rapt lipid droplets and phytovirus infection project undertakes an innovative exploration into the potential role of plant leaf lipid droplets lds in the replication of plant viruses specifically focusing on plant rna viruses lipid droplets which are ubiquitous organelles derived from endoplasmic reticulum er membranes play key roles in energy production membrane biogenesis and stress signalling while certain animal rna viruses utilize lds for energy or as platforms for viral replication compartments vrcs evidence for similar mechanisms in plant rna viruses remains elusive the project builds on the previous observations made by the host lab which suggest a higher abundance of lds in turnip mosaic virus tumv potyvirus infected leaves and their spatial proximity to vrcs the hypothesis is that certain plant viruses like tumv utilize lds as energy reservoirs for their genome replication potentially facilitating direct interaction with vrcs to validate and expand upon this hypothesis the rapt project is defined into three primary objectives1 exploring the impact of plant virus infection on ld distribution and lipid metabolism2 functional validation of the involvement of plant lds in the potyvirus infection cycle3 elucidating the molecular mechanisms governing the interactions between lds and tumvthese objectives address key knowledge gaps regarding the role of lds in plant virus infection and will focus on potyviruses mainly tumv but other ssrna virus species of agroeconomic importance such as luteoviruses and poleroviruses will also be studied with the aim to expand the findings to crops the results of this project will contribute to the development of broadspectrum genetic resistances that can be harnessed by breeders to mitigate the adverse impacts of plant viral diseases on agricultural productivity
|
versatile furanbased polymers for strict and high value applications in packaging automotive and underwater environments
|
he goal of the furious project is to develop novel versatile polymers based on 25fdca to enrich the portfolio of biobased innovative monomaterial solutions proposed to replace traditional plastics the materials will be properly designed from the chemical point of view to satisfy a set of target properties required for three stringent applications where other bioplastics do not address all the requirements or traditional plastics are still widely employed biomedical and electronic packaging where resistance to sterilization and high barrier properties are necessary automotive sector where resistance to uv weathering and intrinsic antibacterial properties are the key feature and underwater devices where photoreactivity and biodegradability in seawater are requested to target such a goal all the wellestablished synthetic strategies will be used with particular attention to the exploitation of green processes to low lifecycle environmental impact polymers and to the minimization of their production cost furious material versatility will be also assessed with respect to their processability which is a further mandatory feature to be checked for real entry on the market both wellestablished technologies such as injection molding and extrusion and more innovative ones such as electrospinning 3d printing and stereolithography will be validated last but not least intrinsic recyclability will be imparted to the new furanbased polymers for both greener and mechanical recycling and for novel enzymatic recycling strategies in the case of packaging compostability will also be evaluated while underwater sensor biodegradability in marine environment will be checked being one of the key requested polymer feature innovative results of furious will contribute to the development of sustainabilitybydesign database used to assess and predict the performance of novel materials and to derive a set of guidelines for the enduse applications
|
increasing metabolic engineering efficiency using a conditionally quiescent fission yeast mutant
|
the proposed project aims to solve a major challenge in metabolic engineering in microbial metabolic engineering platforms consumed nutrients are primarily invested into population growth instead of the production of chemicals of interest our team is studying a temperaturesensitive mutant of fission yeast schizosaccharomyces pombe which grows normally at 26c but enters quiescence at 36c while at the same time maintaining its metabolic activity such an engineering platform could represent the holy grail of the metabolic engineering field a chassis strain that can stop growing but keeps producing metabolites application of such pseudoquiescent strain would be useful to both industrial and academic players to develop this mutant into a new metabolic engineering chassis i will first design a molecular cloning toolkit to perform metabolic engineering in s pombe which will enable construction and expression of complex biosynthetic pathways second i will characterize the phenotype of the pseudoquiescent s pombe mutant using a multiomics approach i will generate knowledge about mrna protein metabolite and flux dynamics to delineate a genomescale metabolic model of the chassis under pseudoquiescence then i will assess the ability of the s pombe mutant to overproduce 3 different highvalue compounds kavain via phenylalanine theophylline via purine and artemisinin precursor via mevalonate finally i intend to reproduce the pseudoquiescent mutant phenotype in other commonly used yeast species saccharomyces cerevisiae and yarrowia lipolytica in the short term this research will deliver a new type of a metabolic engineering chassis for the production of complex chemicals to the metabolic engineering community in the long term it will contribute to the development of metabolic engineering as a competitive alternative of total synthesis of chemicals leading to greener and renewable chemical industry
|
unraveling mechanisms of drug resistance apobec3a as a genomic and posttranscriptional driver of treatment resistance in pancreatic cancer
|
pancreatic cancer is predicted to become the third leading cause of cancerrelated death in europe drug resistance to even the most effective anticancertargeted therapies constitutes a major contributor to poor prognosis in pancreatic ductal adenocarcinoma pdac kirsten rat sarcoma virus kras mutations are found in 90 of pdac being an important oncogenic driver although krastargeted therapies have the potential to transform the clinical management of pdac drastically only a subset of patients respond and resistance is frequent the extent to which genomic and posttranslational processes drive drug resistance remains largely unknown genomic analyses have identified the apobec family as a key driver of mutagenesis in cancer including pdac among family members apobec3a a3a is involved in genomic alteration and posttranscriptional rna editing both mechanisms causative for intratumoral heterogeneity ith and drug resistance my preliminary data reveal that a3a induces chromosomal instability and likely ith in addition i found that a3amediated rna editing is prevalent in human pdacs and a mouse model for a3a importantly i observed that a3a expression increases during krasg12d targeted therapy reduces sensitivity and facilitates clonal outgrowth and thus is likely to drive drug resistance in pdac the adrip study will utilize murine and human models for a3a to unravel for the first time whether a3a plays a dominant role in increasing ith in pdac aim1 second it will elucidate whether a3amediated genomic or posttranslational modifications aim2 drive preexisting and acquired kras inhibitor resistance applying a multiomics approach the adrip study aims to identify novel regulators of a3a that could serve as therapeutic targets aim3 importantly the adrip study may have direct clinical implications as the basis for future preclinicalclinical intervention trials that target a3a to prevent drug resistance in kras mutant cancers
|
green crimes and joint crime ventures laundering natural resources
|
the high value and scarcity of natural resources increasingly attracts criminal entrepreneurs operating in the legal economy the laundering of natural resources is a prime example where illegally obtained natural resources are converted into legal products consequently consumers buy products such as a gold wedding ring a hardwood floor or endangered species as legitimate on the international market and unknowingly become part of a trade with devastating environmental effects to facilitate laundering crime groups interact with corporations and state actors as joint crime ventures the proposed research aims to understand how and why joint crime ventures launder natural resources and what the environmental impact is contemporary developments in environmental crime networks signal the expansion of grey areas of business where the separation between conventional and nonconventional criminals is no longer appropriate for understanding and dealing with the increasing complexities of environmental crime therefore it is essential to develop an innovative approach to fill this theoretical and empirical gap by analysing coercive economic and political interactions between crime groups corporations and state actors this study will build a new line of research and reveal the causes incentives and environmental harms of laundering natural resources the environmental impact of laundering is illustrated by rapidly disappearing rainforests largescale pollution and the mass extinction of species yet laundering natural resources has been the subject of rather limited study this research introduces a novel combination of cluster analysis of environmental crime cases multisited field research and crime script analysis that ensures a unique mixedmethod perspective the insights will be crucial for scientists policymakers corporations ngos and law enforcement to develop inventive solutions to prevent and tackle the laundering of natural resources
|
innovation excellence in construction engineering novel 3d concrete printing technologies and sustainable mixtures
|
the exep3d project aims to expand skills transfer knowledge and raise the innovation capacity of ttks institute of civil engineering in the field of construction engineering with the aim to become a leading competence centre in estonia and europe more specifically in 3d concrete printing 3dcp and locally produced sustainable mixtures by linking the unique competencies of eindhoven university of technology and tu dresden the two leading universities in automation and 3d printing technologies for construction engineering and environmentally friendly mixtures the project has potential to innovate the construction engineering industry as a whole with a wider aim to fill in the gap within eu and raise the scientific and technological excellence of ttk as a representative of estonia a widening country exep3d proposes a combination of staff upskilling academiaindustry partnershipbuilding and applied research activities while consulting with academia and industry experts within 36 months the consortium will deliver 8 staff study visits 13 training seminars for staff and studentsresearchers a student competition 2 openaccess publications on the newly established research direction in costefficient 3d concrete printing formwork and locally produced mixtures technical descriptions and data sheets on the novel approach and annual events with the industry to introduce and further disseminate project results to name a few
|
rereading european cultural heritage in latin american women writers travel literature of the early 20th century contrasting testimonies to build inclusive historical discourses
|
cultural heritage is a sociocultural discursive construction embedded in power relationships which tends towards the selective preservation of historical memory and the support of a particular reading of history however history is multivocal and to achieve egalitarian societies where identity diversity is respected it is necessary to deconstruct the hegemonic historical discourse including different narratives from the perspective of otherness rewind proposes to study how historical discourses around european cultural heritage ech have been constructed using travel literature written by latin american women authors from the early 20th century as such noneuropean women committed to feminist movements and who claimed miscegenation become historical agents and cultural mediators that counteract a eurocentric and patriarchal historical discourse thus it is not about adding womens testimony but about rereading historical narratives about heritage in order to protect and transfer a cultural legacy that reflects the memories and subjectivities of a diverse society rewind is based on foucaults theories of discursive formations since it analyses the elements of the ech that authors highlight in their travels and descriptions from both the physical and the emotional point of view firstly using digital humanities approaches based on geographic information systems the project will identify and locate ech items secondly rewind will apply sentiment analysis techniques to recognise the impressions that ech provokes in women travellers and finally the information offered by travel guides and official documentation of cultural institutions will be contrasted with the data of travel literature applying semantic technologies and the decolonial gender theory so through this innovative methodology rewind will give voice to a silenced testimony recovering part of the collective memory and offering new ways of interacting with the past in the present
|
modernist childhoods the figure of the child in womens fiction 18901950
|
the project will examine representations of children and childhood in womens fiction of the modernist period c 18901950 the concept of childhood became central to late nineteenth and early twentiethcentury british culture when the childfigure was used to explore important questions about identity and gender scientific investigations of children led to views of childhood as a developmental stage the role of which was to prepare the child to become a rational and autonomous adult characteristics associated with ideas of masculinity the project explores how female fiction writers of the period reshaped and rejected malecentred scientific definitions of childhood in order to reimagine the child making it a vehicle for feminist ideas and a propeller of new modes of representation the project will pursue an interdisciplinary approach drawing on expertise in literary studies childhood studies and feminist studies acquired and consolidated through ku leuvens research centres mdrn focusing on modernist culture and lch2 leuven centre for health humanities with a special focus on representations of age this expertise will primarily be developed by trainingthroughresearch under the supervision of elke dhoker an expert on womens fiction and modernist literature the main deliverables will be two journal articles a monograph proposal and an edited collection arising from an international symposium organised at ku leuven the research will also lead to the delivery of four conference papers and communication to nonacademic audiences through european researchers nights a public lecture a newspaper article and a workshop for high school students
|
single molecule nuclear magnetic resonance microscopy for complex spin systems
|
nanotechnology is emerging as a key area to address global challenges in health energy environment and information technologies however we are still investigating most nanomaterials with bulk techniques averaging over large samples instead of looking at one single nanostructure with true nanoscale sensors particularly nuclear magnetic resonance nmr as our workhorse for biochemical synthesis and medical imaging is inherently limited to bulk samples the most fundamental challenge to turn nmr from an ensemblemeasurement technique commercial nmrs typically have a sensitivity of billions of molecules into a nanocale technique remains unsolved in this project we will overcome this challenge by reaching single molecule sensitivity thus converting nmr into an imaging technique thanks to the exploitation of the unparalleled atomic resolution of the scanning probe microscopy spm technology this breakthrough will be based on resonant high frequency electromagnetic excitation and readout including important advances in ghz technology we will use the capabilities of the novel technology to demonstrate detection of single spin nmr and to test the limits of our understanding of nuclearelectron interactions probing the physics of molecular nanoobjects 1d carbon nanoribbons with delocalized coherent states and 2d atomicallythin magnetic materials this novel technology will not only open up new fundamental scientific insights but should also have a strong impact in the markets of nmr and spm in this context the project will be a keystone demonstrating the novel platform conceived as a versatile upgrade for commerciallyavailable spms that can routinely operate in various environments vacuum ambient liquid with a variety of molecules and materials
|
industry empowerment to multiphase fluid dynamics simulations using artificial intelligence and statistical methods on modern hardware architectures at scale
|
multiphase transsupercritical and nonnewtonian fluid flows with heat and mass transfer are critical in enhancing the performance of energy production propulsion and biomedical systems examples include hydraulic turbomachines ship propellers co2neutral efuels and emotor cooling systems particleladen flows in inhalers and focused ultrasounds for drug delivery what all these cases have in common is the high level of complexity which makes direct numerical simulations impossible stateoftheart les simulations rely on simplified assumptions but do not have yet the desired accuracy while often require enormously expensive cpu resources the aim of scale is to develop simulation methods and reducedorder models using physicsinformed and datadriven machine learning and optimisation methods for such flow processes these will be trained against groundtruth databases that will be generated for the first time using both dns and experimentally validated industryrelevant les and multifidelity rans simulations the new simulation tools will be applied for the first time to industrial problems and their ability to accelerate design times and improve accuracy will be jointly pursued and evaluated with the nonacademic partners of scale these are international corporations and market leaders in the aforementioned areas holistic training by experts from science and industry includes broad reviews on relevant scientific topics modern high performance computing architectures suitable for performing such simulations big data analytics as well as extensive support for mastering scientific tasks and transferring the knowledge acquired to industrial practice scale will also deliver soft skills training from a wellconnected cohort of leaders with the ability to communicate across disciplines and within the general public this coupling of research with industry makes scale a truly outstanding network for doctoral candidates to start their career
|
a holistic digital mine 40 ecosystem
|
in the context of industrialization informatization and sustainable development of the mining sector mineio solution will build a novel mining digital ecosystem and a systemic structure for the implementation of industry 40 in mining industrial environments mineio solution will embrace the whole mining value chain from resources exploration extraction and processing to waste management and post mining activity our fundamental concept is the provision of a manufacturing system architecture under cloud environment to be applied in the digital twin mining shop floor mineio envisions an innovative cloud services system and a novel mining ecosystem of sharing interconnection and open cooperation mineio will establish a unified data infrastructure and collaborative platform ecosystem to promote the openness and sharing of data and improve the cooperation environment between mining enterprises mineio aims the enhanced systematization of the basic processes of the mining industry that involve asset and process equipment optimization through embedded predictive analytics and optimization procedures based on completely datadriven processes and the integrated cybervirtual and cyberphysical systems automation and robotization of mining exploration and production processes sustainable mining and post mining management to meet the increasing social and environmental concerns mineio will enable a resource optimization and digital transformation framework embedding specific circular economy and lowimpact mining strategies energy innovations including the transition to autonomous electric vehicles will lead to socially conscious profit while creating a safer and cleaner environment for frontline workers including higher air quality for those working underground mineio ecosystem will be validated in different demonstration sites involving 4 operational mine facilities and 2 historic mine sites in 5 eu countries
|
oxytocindriven territorial mapping in the mammalian hippocampal formation
|
orienting in space recruits brain mechanisms well conserved across mammalian species within the entorhinalhippocampal network a core system of spatiallyselective cells supports spatial geometry computations yet when navigating familiar surroundings neural computations of space usually escape our attention instead we parse space into socially meaningful territories territorial boundaries are social in nature since they capture the location of utilities available to individuals tied to group hierarchy and affiliation how does our brain integrate geometry and territory we propose that this process is regulated by the oxytocin ot system acting on the entorhinalhippocampal regions ot a hypothalamic neuropeptide known for its prosocial effects in mammals modulates neural activity in the hippocampal formation but its potential role in territorial representations has not yet been studied here experts in complementary fields social behaviors spatial navigation neurophysiology anatomy and cell signaling will study brain similarities and differences of socioterritorial strategies in five mammalian species bats mice rats marmosets and macaques our central goal is to investigate how neurons coding for space eg place cells boundary cells grid cells respond to perceived sociospatial parameters of ownership utility and social hierarchies we expect spatial cells to be sensitive to territorial manipulations ownership proximity intrusion regulated by ot in a contextdependent manner ot inhibition may enhance territorial defense when territories are challenged eg conspecific approaches or transgresses borders and may sharpen territorial boundary representations conversely ot stimulation could blur the boundaries of territorial perception our crossspecies perspective will be the first to provide information on possible speciesspecific vs shared neural mechanisms for territorial maps and otinduced hippocampal plasticity
|
dignity for irregular migrants in eu farm2fork labour markets
|
dignityfirm contributes to improving conditions of irregular migrants im working in farm to fork f2f labour markets in four eu member states it nl pl sp and two associated countries mo ua to derive structural recommendations for improvements we analyze regulatory infrastructures that govern these conditions distinguishing five influential spheres of stakeholders at the eu national and local levels and at the level of employers and im themselves the focus on im in f2f labour markets is timely given the instrumental role of these industries in securing eu livelihoods the high systemic dependency on im that coincides with persistent group vulnerabilities by providing knowledge and innovative tools to improve regulatory infrastructures this project enhances ims access to basic rights and services and improves their precarious working conditions doing so we contribute to systemic resilience of f2f industries and the eus ambitions for social and economic transformation our project adopts a mixedmethod research approach that includes a special focus on the division of labour in f2f markets with respect to gender ethnicity socioeconomic status health and safety doing so we provide new knowledge on 1 the multidimensional regulatory infrastructure and the conditions of im therein 2 their access to basic rights and social services and 3 employer reliance on ims we build on our analysis of the current situation and work towards innovative solutions by developing dignity tools in cocreation with stakeholders across the five stakeholder spheres we propose group sensitive policy measures at eu national and local level across four policy domains migration management eu pillar social rights labour market sustainability and corporate social responsibility doing so we create a pathway for impact towards upholding ims access to rights and services and simultaneously addressing labour market needs and wellbeing of host communities
|
what to expect of expec is the success of extraintestinal pathogenic e coli linked to specific genomic and cellular properties
|
extraintestinal pathogenic e coli expec are one of the greatest challenges for the healthcare system with a frightening prognosis for the future despite being heavily studied in recent years no unifying principle explaining their success has been identified only limited attention has been paid to the additional genomic properties of expec strains that are not virulence factors or antimicrobial resistance genes i aim to demonstrate that these additional genomic features lead to alterations in cellular features related to physiology growth ability and metabolism that contribute to expec pathogenic success to do so i will first setup a database of expec specific regions and use this to perform an unbiased largescale screen comparing them to publicly available e coli genomes this analysis will yield specific genomic regions that can be confidently assigned to expec or expec subgroups to further demonstrate the biological significance of these regions highthroughput singlecell phenomics will be employed to quantitatively examine specific strains of interest across different growth conditions and identify the genes or groups of genes present in the expec specific regions associated with specific phenotypic alterations finally the identified genomic regions will be further characterized using a deep mutational scanning approach to uncover the exact molecular mechanisms that underlie phenotypic alterations of pathogenic strains in comparison to their nonpathogenic counterparts i expect this project to bring muchneeded insights into expec physiology linking it with its specific genomic background such fundamental knowledge will contribute to managing expec more effectively in the future
|
devising a personalized risk stratification and holistic management for prevention of cognitive impairment in patients with different cardiovascular phenotypes
|
dorian gray project investigates the link between cardiovascular disease cvd and mild cognitive impairment mci in the ageing population its goal is to uncover underlying mechanisms to promote healthy independent and active living while reducing disease burden aligned with horizon europes strategic plan on ncds prevention the project focuses on two core objectives designing a multidomain intervention to delay cvdrelated mci progression and developing digital solutions to enhance its adherenceby leveraging large datasets that include omics brain imaging lifestyle behaviors and socioeconomic data the project aims to develop a trustworthy ai tool for predicting mci the ai tool will be upgraded into a stateoftheart framework for modelling and simulation digital twin integrating realworld data collected in clinical studies from smartwatches and mobile devices including these digital biomarkers enable the early detection of disease and enhance precision in healthcarethe digital twin will inform and update a personalized multidomain intervention using a novel avatarbased coaching exergame which will serve dual purposes as a cognitive enhancement tool with structured physicalcognitive tasks and as a lifestyle intervention promoting positive behaviours experienced in the virtual environment feasibility will be tested in a pilot randomized controlled trials involving patients with mci and heart failure and in an implementation study with patients having mci and cardiovascular risk factorsto achieve his aim dorian gray brings together a diverse team of experts including clinicians psychologists sports scientists computers engineers ai specialists stakeholders entrepreneurs and academics in ethics law and theoretical philosophy patients and citizens actively engage in shaping and guiding project decisions dorian gray is projected to prevent up to 2 million dementia cases over 27 years leading to a cost reduction of 485 billion
|
environmental contexts during the iberian neanderthal extinction insight from the ecology of ungulate preys envinext
|
the middleupper paleolithic mpup transition is a key period for human evolution as it corresponds to late neanderthals disappearance and their replacement by anatomically modern humans amh after both species briefly cooccurred this multifactorial event happened at different spatial and temporal scales across europe climate constitutes a strong driver of species evolution for neanderthal there is no consensus regarding the impact of climate on its disappearance although it happened during the marine isotopic stage 3 characterized by abrupt and rapid climatic oscillations in order to track climate changes at the time of the neanderthal demise and the evolutionary success of amh ecological proxies filling the gap between local environmental conditions and global climate changes are mandatory herbivore teeth are robust traps for physiological ecological and climatic information and thus mirror past environments envinext implements three complementary ecological proxies on ungulates preyed by both human species from 10 archeological sites covering the mpup transition in north iberia combined dental microwear texture enamel carbon and oxygen stable isotope and molar mesowear analyses provide ecological information at three temporal scales for a global overview of the paleoecology and paleoenvironment of preys and humans envinext has four objectives i exploring the ecology of ungulates key preys for human populations before during and after the mpup transition ii drawing paleoenvironmental inferences at the scale of the territories exploited by neanderthals and amh iii thus linking global climate changes with local environmental changes and asynchronous disappearances of neanderthals through north iberia during the mpup transition finally iv to confront these results for northern iberia a refuge area with what is obtained in southwestern france berliozs current postdoctoral work
|
transnational book diplomacy beyond the cultural cold war towards a sociocultural history of the tamizdat
|
the transnational production circulation and reception of soviet and east european literature in the west during the cold war challenges the dominant twobloc narrative and tells us a different story about the crossborder flow of knowledge and ideas focusing on the intense cultural exchanges of the time across and beyond the nylon curtain an ideological and geopolitical border extremely permeable to cultural objects this research project aims to challenge 1 the traditional representation of western and eastern cultures as divided into two isolated blocs and 2 the representation of tamizdat as a mere ideological weapon of the cultural cold war the term tamizdat published abroad refers to soviet and eastern european texts unpublished in the eastern bloc and clandestinely smuggled and published in the west as an alternative transnational publishing practice with a specific sociocultural value tamizdat highlights cooperation across apparent ideological division and crossborder interaction instead of hostility mikkonen scottsmith et al 2019 the emphasis on smaller national and transnational actors instead of governments ibidem demonstrates the crucial role of book diplomacy in preventing the cultural isolation of the two blocs following o sanchezsibony who questiones from a socioeconomic perspective the representation of the cold war as a bipolar contest between superpowers 2014 i will address the sociocultural dimension of this narrative treating tamizdat as the result of socially and culturally regulated activities i will consider the agency of social activists of social movements dissidents soviet and east european migrs diplomats etc and cultural actors writers editors translators literary agents critics journalists etc who contributed to its transnational production circulation and reception in order to outline a comparative sociocultural history of the cold war
|
global alliance for chronic diseases secretariat
|
the global alliance for chronic diseases gacd brings together leading health research funding agencies to coordinate research activities addressing on a global scale the prevention and treatment of chronic noncommunicable diseases such as cardiovascular diseases diabetes respiratory diseases cancer and mental health the gacd secretariat supports its member agencies by helping to coordinate research priorities and joint funding capacity build for implementation research and promote likelihood of impact by fostering collaborative working across the gacd research network
|
leveraging artificial intelligence to balance tradeoffs in the digital economy
|
libra leveraging artificial intelligence to balance tradeoffs in the digital economy will assess and compute positive and negative impacts on ai systems on society and the environment and it will optimize them to support policymakers in europe and beyond artificial intelligence ai contributes to the development of the digital economy and expands the opportunities for sustainable development however as computing needs grow ai systems and applications raise concerns about their environmental implications acknowledging this tradeoff and achieving an optimal combination between the carbon footprint of ai systems and the benefits they contribute spurring is becoming a key policy concern but remains an unresolved issue by combining finance ai and decision theory libra aims at filling this gap developing testing and proposing policyoriented innovative approaches and tools to i map how investments in ai systems and applications contribute to generating carbon emissions worldwide ii discover how the digital economy enables the achievement of the 17 sustainable development goals sdgs iii compute the optimal balance between carbon emissions and sustainability objectives to inform national policies libra will contribute to the ongoing debate about ai and sustainability by combining approaches from computer science ie natural language processing and deep reinforcement learning complex systems ie network science and economics ie decision theory in a holistic framework the project outcomes will support the discussion around the eu ai act and the development of a solid sustainability roadmap which accounts for the growing opportunities spurred by the digital economy libra will last 24 months and it will be mainly conducted at the royal institute of technology kth in stockholm sweden with a secondment period at the university of zurich uzh in zurich switzerland
|
ecologies of violence crimes against nature in the contemporary cultural imagination
|
the ongoing destruction of the natural world raises critical questions about responsibility how do we remember the victims both human and nonhuman and who is to blame contemporary culture plays a crucial role in addressing these questions largescale processes like ecocide and extinction pose significant conceptual and representational challenges this project posits that writers artists and filmmakers are responding to these challenges by adapting existing repertoires especially ones that emerged in response to the holocaust slavery and other atrocities in so doing they reveal the historical structural and discursive links between crimes against humanity and crimes against nature ecoviolence will be the first comprehensive transnational comparative study of the cultural imaginary of environmental violence bringing together recent work in cultural memory studies and ecocriticism we will develop an innovative ecological model for the study of violence and its representation we will document how texts films art works plays and exhibitions represent ecoviolence map how they link it to colonialism and genocide and analyse how they reflect on questions of guilt and responsibility as well as cultures own implication in the violence it depicts furthermore we will explore how these representations harness affect and emotion to help people relate to the environmental crisis and promote critical selfreflectionecoviolence will effect a major reorientation in cultural memory research and ecocriticism by providing a framework to think about violence and memory in morethanhuman terms the project will result in a best practices guide to engage cultural representations in pedagogy to enhance critical literacies about ecoviolence and move beyond simplistic stories where everyone is either a victim or a perpetrator that have stifled full responses to our collective ecocidal trajectories
|
harnessing the vast potential of res for sustainable farming
|
competitive conflicts for land use between the energy and food sectors have appeared which could be mitigated by the vertical integration of res in farms through new circular business models by this approach farms will become climate neutral optimising their production and reducing their impact on natural resources and biodiversity on top of providing energy services to communities and diversifying their economic income however there is a need to identify understand and overcome major existing barriers perceived by agricultural communities moreover current initiatives do not to effectively consider and address the complex interactions and factors from the farming and res context thus missing to support decision making based on accurate projections estimations and forecasts harvrest will work on these needs by improving the existing knowledge and its fragmented status which will be feed to an agricultural virtual power plant able to run different scenarios and farm configurations to determine the best operation procedures for a given res solution this data will be then provided to a decision support system able to weight tradeoffs and key indicators to provide adhoc recommendations to farmers and policy makers thus enabling the consecution of improved production rates on renewable energy food feed within agro communities for the successful execution of harvrest and implementation of recommendations a multiactor approach fostering cocreation sessions together with the provision of training materials for farmers empowerment will be implemented the full approach of harvrest will be supported and executed at 4 use cases representing different topologies of farms a diversity of stakeholders and organizational structures distinct geographical conditions and a wide variety of res technologies together with harvrest community and mapped initiatives the project will act as a hub for knowledge and bestpractices on res integration at farm level
|
timely detection of a potentially fatal chronic liver disease that one out of four of us have without knowing it
|
evido is a health tech company that originates from the clinical world and stands on top of more than a decade of extensive clinical research from the elite center of liver research at odense university hospital we are a team of hepatologists clinical researchers data geeks venture builders and healthcare innovators all sharing a common goal to help people at risk of chronic liver disease by reinventing diagnostics with evidencebased and datadriven solutions our mission is to ensure timely detection and support of atrisk people that unknowingly have a potential fatal disease we see the women techeu programme as a great opportunity that will front load our commercial traction and accelerate our time to market up to this point we have achieved to attract funding to cover our product development cost and regulatory affair we have achieved to set up international collaborations to mature our data model and test our solution all key activities to get liverpro to market and accelerate our adoption to build on this traction and ensure a holistic perspective on our business we want to broaden our activities and start frontloading our commercial activities already in the beginning of 2023 we see women techeu as a brilliant programme to support us in doing exactly this women techeu can give us a resource boost to expand our focus and enable us to pursue commercial traction in parallel to getting liverpro to the market we see a huge value in being part of the mentoring and coaching part of the programme and could really benefit from getting input on rollout strategy pricing sales processes pilot sales etc the combination of both financial support and specific coaching will help us accelerate our commercial traction and build a robust gotomarket strategy
|
decentering eighteenthcentury political economy rethinking growth wealth and welfare in the swedish empire
|
the project reassesses the early history of european political economy historians of political economy have traditionally concentrated on the genesis of modern economics tracing the emergence of economic models methods and ideas that are today recognized as economics through classical political economy neoclassicism and on to the presentthis new departure treats political economy as a discourse oriented to the improvement of conditions for human life and as such one of the enlightenments key contributions to western thought however any direct association of enlightenment discourse with political economy requires qualification therefore this project explores a very extensive contemporary literature about growth wealth and welfare that has not fitted easily into the conventional retrospective history instead of converting past arguments into modern arguments about methods and models the project investigates eighteenthcentury political economy in terms of practical concerns as measures and policies for betterment and improvement only in this way we can reconstruct what political economy meant to its contemporaries in the early modern period the swedish empire considered by contemporaries as the stronghold of oeconomia functions as the primary case study but is constantly compared with other cases broadening the applicability of the findings the aim of the project is to study the ways in which the key concepts of improvement wealth growth and welfare were articulated in the main sites of discursive production the university the diet local and colonial governments and academic journals the study of the five institutions is based on the hypothesis that in each of them activities were directed towards improving the organisation of state and society and the living conditions of the people this project represents a wellfounded reassessment of the rise to predominance of economic argument during the eighteenth century
|
improving tourism and hospitality worker wellbeing through social dialogue
|
tourism and hospitality th make up over 10 of the european economy and 117 of employment many of the 13 million employees in the eu are from marginalised groups women 54 migrants 16 and youth 30 ilo 2022 however staff turnover and vacancies are high with 12 million job vacancies 11 in the eu many th workers are in nonstandard forms of work including platform work this is detrimental for employees a decent work deficit lack of social protection increased precarity and vulnerability and increased inwork poverty european parliament 2021 furthermore algorithmic management impacts negatively on these workers generally considered as selfemployed platform workers risk exploitation forced labour mistreatment and sexual abuse their precarity is increased due to legal knowledge and financial obstacles they face in representation and social dialogue structures futourwork will investigate how all th workers can be included in social dialogue and understand and tackle the challenges of the associated distributional costs while acknowledging a variety of social dialogue arrangements and processes reflecting different historical economic and sociopolitical backgrounds this project researches the changes in the new world of work examples of best practice and identifies common issues that can be tackled at a european levelusing an intersectional gendersensitive approach futourwork will use quantitative and qualitative techniques including surveys mapping interviews story telling and multistakeholder learning dialogues futourwork will produce an index that can be used by industry to benchmark their workers wellbeing workers stories will be collected and a documentary produced to enhance public understanding we will develop an observatory to integrate the information produced and as a platform for dialogue for workers legal and social dialogue organisations and employers
|
leveraging the european xr industry technologies to empower immersive learning and training
|
xr2learn will deliver the xr2learn platform around which it establishes a crossborder innovation community for xr in learning bringing xr technology providers application designers education experts application developers endusers and decision makers in direct access to communicate collaborate and matchmake interests enabling also bottom up innovation creation xr2learn will go beyond offering sound technical and business support for the creation of xr applications for education xr2learn will provide access to authoring tools for development of applications through its platform deliver tools for emotionaffect detection and for automated adaptation of the learning experience to the user needs and emotions deliver guidance relevant to educational design and use case definition provide opportunities for piloting and user testing mediated by the large networks brought by xr2learn partners promote tools that enable and boost the reuse and sharing of the learning materialsxr applications offer business development support and additionally support ipr management through nfts enabling novel business model implementation xr2learn will support innovators ictsmes all the way from ideation to commercialisation offering them tailored business and technical support as well as direct funding through fstps
|
proteinbased next generation electronics
|
recently an entirely novel type of bacteria has been discovered that can guide high electrical currents over centimeterlong distances through long thin fibers embedded in the cell envelope recent studies by pringle consortium members reveal that these protein fibers possess extraordinarrecently an entirely novel type of bacteria has been discovered that can guide high electrical currents over centimeterlong distances through long thin fibers embedded in the cell envelope recent studies by pringle consortium members reveal that these protein fibers possess extraordinary electrical properties including an electrical conductivity that exceeds that of any known biological material by orders of magnitude the ambition of pringle is to unlock the vast technological potential of this newly discovered biomaterial to this end we propose to utilize customcrafted protein structures as elementary active and passive components in a new generation of biocompatible and biodegradable electronic devices the resulting longterm technological vision is to establish a radically new type of electronics proteonics that is entirely biobased and co2 neutral and in which protein components can provide different all types of electronic functionality pringle will provide the fundamental and technological basis for proteonics by 1 developing fabrication and patterning technologies for proteonic materials and nanostructures 2 tuning the electronic properties of these proteonic materials in a fitforpurpose manner and 3 integrating proteonic materials as functional components into allprotein electronic devices as such pringlebased technology could provide a significant breakthrough towards next generation electronics applications in a circular economy opening entirely new avenues for interfacing biological systems with electronics and allowing completely new sustainable production and recycling pathways for electronic components
|
enabling wireless information and power transfer through lowcomplexity waveform techniques
|
wireless information and power transfer wipt is a new communication paradigm which is based on the dualuse of radiofrequency rf signals as a means to convey information and energize low power devices wipt is an attractive and promising technology for the upcoming 6g communication systems which are characterized by the massive connectivity of heterogeneous ultralowpower devices under the umbrella of the internet of things iot due to the nonlinearity of the rectification process the efficient design of wipt requires an essential rethinking of the entire transceiver chain including the waveform design at the transmitter side specifically experimental and theoretical results have demonstrated that signals with high peaktoaverage power ratio papr such as multisine signals are efficient for rf harvesting these signals admit periodic high energy peaks that enable us to overcome the buildin potential of the diodes on the other hand it is wellknown that papr has a detrimental effect on information transfer thus calling for a sophisticated codesign of the informationand energy signals to resolve this issue and accommodate these conflicting goals the goal of the wave proof of concept poc is to demonstrate in realworld scenarios two novel multisinebased wipt waveforms that achieve a desired informationenergy transfer efficiency balance we aim to further investigate and implement the toneindex multisine tim and frequencydomain wipt fdwipt waveforms that have been developed in the erc consolidator grant apollo the two proposed waveforms exploit papr in a controlled way and are characterized by extremely low complexity which makes them attractive for practical iot applications the experimental validation of the developed waveforms will demonstrate their benefits in comparison to the current state of the art and willconstitute a useful tool for attracting potential industrial stakeholders and exploring commercial avenues
|
promoting and incentivising federated trusted and fair sharing and trading of interoperable data assets
|
pistis brings forward a reference federated data sharingtrading and monetisation platform for secure trusted and controlled exchange and usage of proprietary data assets and datadriven intelligence pistis will advance the available techniques and technologies such as federated data discovery and sharing dlts data nonfungible tokens nfts aidriven data quality assessment and monetisation to build trust among stakeholders and assuage their concerns such stakeholders will formulate a distributed network of existing and new data spaces with builtin governance brought by pistis to eliminate silos while accruing the actual data value and multiplying it through derivative assets in a fair and transparent manner taking into consideration the data supply and demand perspectives pistis will establish the methodological and technical foundations across different axespistis federated data management interoperability governance that aims at collecting curating securing and fully controlling the data made available through each organisations data spacepistis federated secure data sharing that concerns the effective management and onchain storage of multiparty data contracts in an inherently humanunderstandable manner as well as the secure peertopeer data transfer and usage monitoring mechanisms for appropriately retrieving provisioning selfserving ondemand and tracking the appropriate data slices according to the relevant contract provisionspistis data valuation and monetisation to systematically articulate and recommend an appropriate target value indicatively taking into consideration the cost approach the income approach and the market approachpistis data sharing skills cultivation that provides the training material to educate stakeholders into how they can assess their data sharing maturity proceed with data deployoperate the pistis technologies and implement an effective and sustainable data sharing strategy
|
abundance of rational points on lowdegree del pezzo surfaces
|
describing the set of rational solutions to polynomial equations is the oldest field in mathematics and one of the fundamental goals in number theory in arithmetic geometry such solutions are studied using geometric tools rational solutions to equations correspond to rational points on the corresponding geometric objectfano varieties are among the simplest geometric objects but still far from fully understood this makes them a great class to test conjectures and develop new techniques it is generally believed that fano varieties if they have a rational point should have many and they should be welldistributed for curves dimension 1 this is the case fano varieties in dimension 2 are del pezzo surfaces and already here there are many open questions these surfaces have been a very active area of research in the last 50 yearsdel pezzo surfaces are classified by their degree an integer between 1 and 9 the lower the degree the more complex these surfaces become and especially del pezzo surfaces of degree 1 are notoriously difficult current results on the rational points on these surfaces make use of adhoc constructions and a general geometric approach is missing this forms a sharp contrast with del pezzo surfaces of higher degree and leaves a big gap in the understanding of rational points on fano varietiesthis project proposes to create a systematic approach to construct rational points on del pezzo surfaces of degree 1 and use this to prove several different results on abundant rational points for new families of surfaces this will lead to answering big open questions unirationality hilbert property and weak weak approximation for del pezzo surfaces of degree 1 and providing evidence towards a longstanding conjecture on rational points on rationally connected varieties recent developments on the construction of rational points and lowgenus curves on del pezzo surfaces make this the perfect time to tackle the proposed objectives
|
road trailer design use of type v thermoplastic tube with light composite structure for hydrogen transport
|
nowadays existing trailer transportation solutions use tubes with a working pressure between 200 and 300 bar this is not efficient in terms of quantities or cost to address large refuelling stations knowing the upcoming rampup of fuel cellbased vehicles the overall objective of the road trhyp project is to develop and validate a trailer integrating new thermoplastic composite tubes type v to reach clean hydrogen partnership objectives by maximising the quantity of h2 transported while satisfying enduser requirements safety ability to be decontaminated and enforced regulations with a low tco by the end of the project the consortium will design a trailer capable of handling a payload of 15 tonne of h2 with 700 bar tubes and a capex lower than 400 kg this enables the decrease of the number of transport rotations between the site of production and the delivery site consequently the reduction of the environmental footprint of transporting compressed hydrogen but also a downsizing of the compressor at the hrs in the meantime the project will heavily investigate new fire testing methodologies and safety barriers for type v adoption results which will be disseminated to key policy makers and regulatory committeesroad trhyps overall ambition is to develop europes value chain of type v technologies more specifically the project intends to address all manufacturers across europe who could benefit from the projects innovative process and materials beyond the targeted commercial type v trailers applications the knowledge developed on composite materials could benefit main actors in the mobility sectors or the hydrogen storage for interseasonal energy storage as a consequence the project would help achieve the european green deal making hydrogen a widespread energy carrier by 2030
|
altermagnetism and spintronics without magnetization and relativity
|
magnetically ordered crystals are traditionally divided into two basic phases ferromagnetism and antiferromagnetism the ferromagnetic order offers a range of phenomena and device applications the vanishing net magnetization in antiferromagnets is potentially favorable for spatial and temporal scalability of devices recently our team and others have predicted instances of strong timereversal symmetry breaking and spin splitting in electronic bands typical of ferromagnetism in crystals with antiparallel compensated magnetic order typical of antiferromagnetism our central idea resolving this apparent fundamental conflict in magnetism is that symmetry classifies a third basic magnetic phase its alternating spin polarizations in both crystalstructure real space and electronicstructure momentum space suggest a term altermagnetism we will demonstrate that altermagnets combine merits of ferromagnets and antiferromagnets that were regarded as principally incompatible and have merits unparalleled in either of the two traditional basic magnetic phases in objective 1 we will establish materials landscape of altermagnetism and in objective 2 show how its anisotropic dwave nature enriches fundamental physics concepts of lifted kramers spindegeneracy fermiliquid instabilities and electron quasiparticles this will underpin our development of a new avenue in spintronics elusive within the two traditional magnetic phases based on strong nonrelativistic spinconserving phenomena without magnetization imposed scalability limitations and with complex functionalities in objective 3 we will demonstrate altermagnetic giantmagnetoresistive multilayer memory devices in objective 4 we will realize logicinmemory analog functionalities in singlelayer nanoscale devices via atomicallysharp altermagnetic domain walls written by pulses scaled down to femtoseconds and forming networks of selfassembled atomicscale giantmagnetoresitive junctions
|
physics informed machine learningbased prediction and reversion of impaired fasting glucose management
|
the incidence of undiagnosed diabetes accounts for 36 european adults while 541m adults worldwide have impaired glucose tolerance igt an important risk factor for further t2d development both igt andor impaired fasting glucose ifg are intermediate glucose mishandling ie intermediate conditions in the healthyt2d transition and are manifestations of the socalled prediabetes condition prediabetes itself is not an extensively studied condition compared to the overt t2d but it is also a condition that can be reversed without the prescription usage to not proceed into t2d the aim of our project is to develop a prototype tool for the realtime prediction of the prediabetic risk based on a series of patientspecific mathematical models firstly developed during the fp7 missiont2d project that simulate metabolism pancreas hormone production microbiome metabolites inflammatory process and immune system response the prediction algorithm will be based on a physicsinformed machine learning approach a rich dataset of reallife data will be combined with a mathematical model to overcome the limits of a blackbox ml approach while reducing the computational time for simulating the solutions of a heavy mathematical models and improving its prediction performanceswe will collect the necessary training data eg diet questionnaire physical activity blood metabolites and microbiome from already existing clinical studies used as retrospective trials which are representative of the reallife scenarios of a prediabetesdiabetes risk insurgence in adulthood 2080y family history metabolic syndrome liver disease and obesity a newly dedicated multicentric pilot prospective observational study will be also performed during which we will also equip the participants with wearable sensors eg glucose monitoring bioimpedance heart rate accelerometer
|
large scale system approach for advanced charging solutions
|
the number of batterypowered electric vehicles is expected to be at 3040 million by 2030 in the eu this strong increase of electric vehicles is a big challenge for the energy system in europe but at the same time a chance to use v1gv2gv2xtechnologies as vehicles are mainly parking they can be used as energy storage in order to increase grid stabilitythe overall project objective is to optimize the entire charging chain from energy provision to the end user to create a clear benefit for all stakeholders therefore a ubiquitous ondemand charging solution based on an optimized charging network considering human technical and economic factors along the entire charging chain shall be developed the investigation of the user behavior as well as the analysis of the energy system and grid will form the basis from a research side to predict the future behavior of ev owners and fleet operators as well as possible shortcomings in the electric grid and energy system the development of advanced charging technologies and control mechanisms as well as advanced charging and sector coupling concepts will form the basis for the virtual and real evalulationsdemonstrations conducted in 4 different european countries belgium germany italy portugal in parallel a smart charging simulation environment digital twin of the charging chain with a holistic simulation environment with multilevel component models and representative information flow between all agents will be built up this digital twin will incorporate the results of the demonstration actions and enable an upscaling to show the impact of these technologies to ensure the interoperability and the optimization along this charging chain the consortium comprises all relevant partnersstakeholders energy providers grid operators charge point operator ev equipment providers as well a vehicle manufacturer
|
biorthogonal catalytic scaffold for in situ personalized cancer chemoimmunotherapy
|
in this fellowship i will leverage the recent advances in biorthogonal chemistry to develop an implantable catalytic hydrogel for chemoimmunotherapy through transition metalmediated biorthogonal drug uncaging the past decade saw incredible advances in the field of cancer immunotherapies with immune checkpoint blockade therapies and chimeric antigen receptort cell therapies demonstrating clinical efficacy however issues still exist as lifethreatening side effects and limited patient response therefore there is a huge need for innovative solutions to improve immunotherapies outcome this project seeks to apply the materials and reaction engineering competence of the applicant together with the biomaterials expertise of the stevens lab karolinska institute to design a nanocatalystdoped hydrogel with tailored geometry as the first biorthogonal catalytic system for cancer immunotherapy the biomaterial developed in this fellowship will address cancer immunotherapy through a completely unexplored approach catalytic uncaging of nontoxic prodrugs to their active form through metalcatalyzed depropargylation reactions completely orthogonal to biological processes the implant will enable uncaging of two toxic drugs a chemotherapeutic doxorubicin inducing immunogenic cell death and an immunostimulant drug r848 a tlr78 agonist the combination of drugs activated by the implant will enable localized cancer cells death with release of cancerspecific antigens antigens then uptaken by antigen presenting cells eventually eliciting antitumor immunity towards a personalized cancer vaccine the design of the scaffold will be guided by principles of biomaterials design and catalytic reaction engineering working in the stevens lab i will access stateoftheart equipment for materials synthesis and characterization and cutting edge facilities to study the cellmaterial interactions in vitro and characterize the efficacy of the envisioned treatment
|
methods and tools supporting digital product service system passport
|
modern industrial companies aim to extend their products with services as fundamental valueadded activities the key potential of the concept of product service system pss besides radical improvements in the use of products is a reduction of environmental footprint of products and services the overall footprint of pss is still insufficiently investigated the services within pss are an important insufficiently used source of digitalized data on the product and its use it is likely that digital means facilitating provision of consistent track and trace information on the origin composition and entire life cycle not only of a product but of all services offered and used around the product will offer important contribution towards achievement of full circularity for manufacturing the key idea of psspass is to investigate how extension of dpp to digital product service system passport dpssp can be effectively achieved and how it will allow for improved circularity of the manufacturing industry the overarching hypothesis is that lca underpinned by machine learning ml methods and informed by dynamic data paves the way to more accurate lca while supporting pss life cycle decision making the collected and sharable data from dpssp will allow to effectively apply ml as well as digital twin dt for more reliable decisionmaking processes concerning circularity of pss the project will provide methodological framework for definition development and update of dpssp digital environment for dpssp built on existing interoperability architectures set of ontologies for improved interoperability at dpssp environment novel dtbased simulation framework for modelling standardized and interoperable dts for pss lifecycle analysis and ai based methodtool to forecasts the environmental impact of pss the psspass solutions will be tested and evaluated within 3 pilots in diverse sectors home appliances complex equipment and textile industry
|
integration of heterogeneous data and evidence towards regulatory and hta acceptance
|
iderha will address the key obstacles to achieving appropriate access sharing use and reuse of lung cancer data and thus enable enhanced regulatory and hta decisionmaking recommendations for integrated health research with the aim to improve care and better meet the needs of patients and health care professionals the iderha open platform for multimodal health data will enhance innovation in eu health care systems and is directly scalable by means of connecting additional systems data sources and additional services and tools it will extend and elaborate standards in semantic interpretation data quality ethics and transferability to ensure the harmonisation of heterogeneous data sources and wider health data reuse use cases positioned along the lung cancer patient pathway will be implemented using retrospective data and in a remote patient care context these practical implementations will demonstrate the added value of multimodal data aggregation and analysis with impacts expected on public health patient burden health outcomes and cost we will perform aiml based lungcancer risk profiling using patients ehrs and improved ct image based aiml to provide risk prediction of potential lung cancer patients and explore the possibilility of personal prognosis of disease progression using patient monitoring and engagement including digital biomarker proms and connected devices the iderha platform will enable remote patient monitoring and provide data for joint patienthealth professional decision making along with health care stakeholders iderha will develop consensus policy recommendations for appropriate data sharing to enable multistakeholder research informed by patient advisory groups we will address critical obstacles and issues to heterogeneous health data primary and secondary use regulatory and hta agencies will be engaged to create criteria for assessing the acceptability of heterogeneous health research results in regulatory and hta decisionmaking
|
personalised health cognitive assistance for rehabilitation system
|
strokecaused cognitive and neuromotor impairment is currently an increasing burden poststroke deficits are commonly believed to be treated with rehabilitation direct medical costs of stroke are stimated to increase up to 943 billion usd only in us the indirect costs including nonhealthcare costs are estimated at 159 billion the journey towards recovery includes several stages from hospitalization to inpatient and outpatient rehabilitation and the subsequent return to home not everyone has access to rehabilitation programs and the gains of them tend to deteriorate after hospital discharge focused stroke rehabilitation reduces longterm disability and the economic burden of stroke and supports prevention by lessening modifiable risks the objective of phrase personalised health cognitive assistance for rehabilitation system is to create a workflow that integrates the best available scientific knowledge and obtain an efficient prognosis and intervention protocols for stroke and other brainrelated diseases it will not only allow to treat strokecaused impairments better and more efficiently but also it is a potential treatment for other neurological diseases like dementia aphasia and psci depression or multiple sclerosis eodynes phrase will be based on rgs previous technology developing its technology readiness level the present consortium brings together a comprehensive group of highly qualified experts so that eodyne can successfully produce prognosis and intervention individualized protocols ebrains will be the brain database and charit will provide with its brain models for the combination of data brain specslab will bring its knowledge in cognitive rehabilitation and will act as clinical coordinator while saddlepoint science brings the expertise to implement the ai tools for continuous improvement of the intervention protocols
|
improve the shelf life of perishable goods through stabilization of vitamins
|
food processing industries face great pressure to increase the shelf life of goods decreasing the tons of waste generated every year at the same time consumers are becoming more conscious about their choices and more critical about the use of synthetic preservatives the most common group of chemical compounds used to preserve the freshness of food are vitamins also known as antioxidants antioxidants are compounds capable to inhibit oxidation which is a chemical reaction that leads to the production of free radicals involving the possible damage the cells antioxidants such as vitamins vitamin c ascorbic acid or vitamin e tocopherol end these chain reactions for that reason many food supplements and cosmetics are constituted by these vitamins to prevent their early degradation is of maximum interest and it is the objective of this project to disclose the use of deep eutectic systems des to increase the shelftime of these compounds des are mixtures of two solid species that at particular molar ratio form a new compound with different properties the team has demonstrated already that the use of this technology enhances the antioxidant activity up to 5 days and prevents fruit oxidation up to 48 hours contrarily to what happens with conventional methods which only prevent food oxidation up a couple of hours within this proof of concept the team intends to validate the product in terms of its technical features but also validate the market and evaluate the commercial potential of our solution
|
conditions for responsible research of srm analysis cocreation and ethos cocreate
|
experimental research on solar radiation modification srm is controversial and feared to distract from climate change mitigation or leading to dangerous srm use it is not clear whether and under which conditions and governance arrangements experimental srm research may be desirable for reducing uncertainties and lowering the probability of problematic outcomes including unilateral deployment elsewhere cocreate seeks to help structure this decision problem through cocreative scoping analysis and engagement for the development of principles and guidelines the project starts with a series of scoping notes that outline key dimensions of experimental srm research including possible cases and their geographical stake and rightsholder and regulatory implications which ground the conceptual work cocreate then analyses and develops decisionsupport tools by asking what we can learn from governance analogues and how various risk evaluation frameworks may help identify key characteristics of research proposals cocreate furthermore analyses possible legal and procedural conditions including appropriate participation cocreate itself will for the development of these governance elements enter an extensive stakeholder and rightsholder dialogue that validates preliminary analytical work ensures stakeholders diverse dimensions of concern are included and strengthens deliberative capacity cocreate proposes guidelines and principles to facilitate decisionmaking by the relevant authorities on broader categories of experimental research of srm as well as casebycase decisions a draft will be discussed at a cocreate hosted conference and later refined based on feedback received proposed principles and guidelines will be grounded in a understanding of scientific merit physical and political dimensions of risk and riskattenuation benefit and consideration of broader sets of values and concerns cocreatively identified during the project
|
spatiotemporal analysis of mammalian embryonic development at singlecell level
|
mammalian early embryonic development requires exquisite spatiotemporal gene regulation at the level of individual cells however it is still unclear and remains a fundamental challenge how cell behaviours govern gastrulation and organogenesis in early embryos two techniques have recently been developed to investigate cell fate decisions in early mammalian development spatial transcriptomics at singlecell level or to study the dynamic transition from single cells to fully formed organisms in toto imaging and if only these two techniques could be combined would we be able to link cell motion with cell state and more completely understand developmental processes there is precedence for combining live cell imaging with gene expression data in ascidians and annelids but this has yet to be done at scale in more complex mammalian systems to this end the proposal aims to investigate early mammalian development by linking spatial transcriptomics and in toto imaging data this will be the first combination of realtime tracking of cellular dynamics and spatiotemporal gene expression profiles across the developing embryo thus providing insight into how cells move interact with each other and how they regulate their own gene expression ultimately revealing the fate that cells adopt accordingly i will develop a novel integration framework and generate the first cellularresolution mammalian embryo developmental gene expression map in four dimensions that reflects both cellular dynamics and spatiotemporal gene expression profiles at the singlecell level moreover this work will pave the way for multiomics integration which has been increasingly explored but to date is confined to the singlecell space
|
designing manyparticle wavefunctions in mesoscopic quantum devices
|
atomically thin semiconductors are emerging as an important class of quantum materials that provide groundbreaking functionalities in device architectures in particular tailoring quantum degrees of freedom associated with charge spin and orbital quantum numbers as well as twist angle could enable novel electronic spintronic valleytronic and twistronic applications these fascinating properties are all contained in the quantum mechanical wavefunctions associated with the charge carrying electrons and holes of the semiconductors here i will prepare heterostructures of twodimensional 2d transition metal dichalcogenide semiconductors and use the strong manybody interactions in the materials to generate condensates of electronhole pair excitations the manybody wavefunctions of these socalled exciton condensates will be visualised for the first time using advanced photoemission spectroscopies that provide complementary access to the energy momentum time and lengthscales of the excitations i hypothesise that this fundamental level of control of the underlying quantum mechanisms of the semiconductors will ultimately enable highly specific quantum engineering of 2d optoelectronic devices i will combine my expertise on nonequilibrium femtosecond dynamics of 2d semiconductors with the capabilities of my host group at aarhus university denmark in order to gain access to multiple photoemission spectroscopy experiments with nanoscale spatial resolution and femtosecond timeresolution as well as 2d material fabrication facilities these new skills and networking opportunities will ultimately enable me to obtain a permanent academic position
|
propelling european leadership through synergizing aviation research
|
aviation sector faces many challenges such as achieving technological breakthroughs reducing its environmental impact and increasing the sectors workforce skills while complying with new eu policies and priorities such as the european green deal the new european industrial policy as well as the european digital strategy a policydriven european aviation ri framework is needed more than ever the primary goal of pulsar is to support the european policymakers in identifying the key aviation research efforts to carry out until 2050 and beyond with respect to environmental objectives associated regulations and expectations of the european citizens pulsar will develop the european aviation ri roadmap and will provide associated recommendations pulsar will focus on the environmental aspects of the overall roadmap ie on technologies that may affect aviation noise and emissions both for impacts on climate co2 and nonco2 effects and for local air quality laq the project also aims at fostering connection of aviation ri with education and skills and communicating about european aviation ri to citizens and relevant stakeholders coordinated by onera pulsar gathers a multidisciplinary consortium of 12 partners composed of industrial partners smes rtos universities and an association relying on a large group of experts such as enea and ecats and clusters whose expertise and complementarity are crucial for the achievement of the projects objectives pulsar will deliver a ri roadmap assessing the impact of technologies on environmental issues and stating the ri effort needed to achieve environmental goalsan educational roadmap to guide training of future experts for sustainable aviationa thorough communication towards citizens on how the sector is committed to lower its environmental footprinta european platform for environmental aviation embedding all project outputs being an open access reference for environmental aviation
|
bidirectional brainneuralcomputer interaction for restoration of mental health
|
more than 1 billion people worldwide suffer from compromised mental health due to a brain disorder such as depression addiction obsessivecompulsive disorder ocd or dementia while already accounting for 19 of all years lived with disability the relative share of these disorders is further increasing currently due to the complexity of the human mind and brain effective and side effectfree treatment options are lacking to establish such options would not only require identifying the underlying neural substrates of clinical symptoms but also effective means to directly modulate them while advanced neuroimaging could link specific clinical symptoms to the metabolic activity of cortical and subcortical networks or neural circuits it is unclear how this metabolic activity translates to the continuously evolving dynamics of widespread brain oscillatory activity a possible way to identify and target such oscillatory brain states would be the use of millimeterprecise and brain statedependent neuromodulation eg using electric or magnetic fields however this could not be established yet because reliable and accurate assessment of brain oscillations is impeded by stimulation artifacts moreover there are no stimulation tools available that provide sufficient focality and steerability to target dynamic brain states at multiple locations with millisecondprecision building on our previous work we will overcome these limitations and establish a new approach that combines quantum sensors offering unprecedented accuracy with closedloop temporal interference magnetic stimulation to target cortical and subcortical areas at millimeter and millisecond precision the system will be validated in persons diagnosed with depression ocd addiction and dementia finally the paradigm will be implemented in a portable system to foster fast adoption in clinical environments
|
autotuning manipulation and braiding of topological quantum bits in tapered nanowire networks
|
quantum computers will revolutionize multiple technology fields which will have a massive impact on society in areas such as communication healthcare machine learning artificial intelligence finance materials research and development and aerospace designing currently the commercialization of quantum computers for real life applications is still a long shot due to major technical challenges like decoherence a process in which the environment interacts with quantum bits and changes their quantum behavior causing computing errorstopological quantum computer platforms offer an alternative route where the topological nature of quantum bits protects them from decoherence therefore not needing error correction protocols that constraint development of commercial quantum computing systems these mainly rely on majorana zero modes which are topological boundary modes predicted to be decoupled from decoherence topological computation is achieved by braiding of majorana zero modes but their manipulation is still an experimental challengethe topotapered project aims to develop tapered nanowires and tapered nanowire networks as a scalable technology for autotuning transportation and braiding of majorana zero modes bound at ends of topological superconducting segments the innovative tapered nanowire platform for quantum computers will support topologically protected quantum bits making it possible to incorporate the large number of them needed for processing quantum information in quantum computers hence topotapered will develop a simplified quantum computer architecture which will be both robust and scalable and therefore will shorten the time to market for quantum computers furthermore to ensure the successful commercialization of our innovation we will identify our product position in the quantum computing value chain and define the most suitable commercialization plan to establish a sustainable business model for topotapered
|
laserasaservice digital platform with dynamic beam shaping for acceleration of smart decentralised and sustainable factory of the future
|
digital servitisation of manufacturing allows to produce ondemand customised products with high quality flexibility and short lead time although this is a wintowin situation there is a lack of methodologies to reverse this trend the project lasers4maas will spearhead innovations in manufacturing technologies and digital platforms with associated services the ultimate goal is to enable a 6point strategy reconfigure connect control predict improve comply to operationalise the smart decentralised and sustainable factories of the futurelasers4maas is set to deliver breakthroughs that merge manufacturing technologies with cuttingedge digital innovations it marks significant scientific and technical advancements in several areas the latest advances in dynamic beam shaping and modular production schemes to maximise flexibility and reconfigurability harmonized protocols and distributedcentralised ledgers for data interoperability across factory boundaries iiot solutions for remote monitoringpredictive maintenance realtime aibased decision support for improved product qualityadvanced physicsbased digital twinslife cyclebased tools for environmental impact and costing assessment the lasers4maas digital platform with its comprehensive range of services and breakthroughs will be demonstrated in automotive fusion food packaging aerospace and hydrogen sectors which are considered strategic sectors for reaching the green deal objectivesthis consortium comprising 4 academic partners 8 industrial partners and an industry advisory board ensures a seamless progression from trl 4 to 6 with welldefined exploitation routes while supporting standardisation initiatives such as digital product passport and facilitating training initiatives and knowledge transfer
|
datadriven and usercentered content moderation
|
online platforms apply moderation interventions mis to mitigate misbehavior today mis are onesizefitsall meaning that each intervention is applied in the same way for all users however not all users are the same as they have diverse demographics ideologies and personalities this naive approach to content moderation is platformcentered and neglects user differences moreover content moderation resembles art more than science the design of mis is based on common sense and intuition and progress is sought via trialanderror rather than via a rigorous scientific process the inevitable consequence is that current mis have variable effectiveness are highly unreliable and fall short of the moderation needsthe ambitious goal of deduce is to initiate a paradigmshift in content moderation by building the theoretical and methodological foundations to move from intuitiondriven approaches enforced via onesizefitsall mis to sciencedriven strategies grounded on personalized moderation interventions pmis we will develop causal methods and indicators to evaluate the effectiveness and fairness of current content moderation practices then we will study how user characteristics influence the outcomes of moderation finally we will leverage the acquired knowledge to design and evaluate pmis a firstofitskind endeavor our datadriven approach will enable us to evaluate in advance the effects of many mis whatif analyses and to plan ahead their application rather than to assess and correct afterwards the highgain nature of deduce is evident as it will open new directions of research eg the design of pmis while also providing major practical and social benefits our results will yield groundbreaking advancements in the theory and practice of content moderation and will be embodied in i practical guidelines for moderators and policymakers and ii an opensource proofofconcept system to support both human and automated moderation
|
plasticity of endothelial cell as new target for acute myeloid leukemia therapy
|
acute myeloid leukemias aml are aggressive blood cancers with poor overall prognosis the main intervention line is highdose chemotherapy often associated with resistance relapse and longterm side effects although predominantly considered as genetic diseases of the hematopoietic system aml also affect the bone marrow bm microenvironment which contributes to disease pathogenesis particularly we have revealed a thorough remodeling of the vascular tree with endothelial cells ecs displaying dismantled junctions and an embryoniclike molecular signature our research hypothesis is that this embryoniclike ecs eecs displaying a high grade of plasticity are progressively enriched during aml progression and foster a leukemiareinforcing environment thus this proposal aims at 1 deciphering the nature of enriched eecs in aml pathogenesis and 2 identifying effective strategies to target them to improve therapeutic response to this end we will combine in vivo lineage tracing and omic studies in consolidated transplantable models of aml and patientderived samples to decipher the molecular and clonal dynamics of bm ecs as well as their phenotypic plasticity toward regained endothelialtohematopoietic and endothelialtomesenchymal transition potential we will next explore novel therapeutic avenues by targeting microenvironmental plasticity in aml via candidate genes associated with the aforementioned phenotypes in vivo with engineered crisprnanobodies finally this knowledge will be translated to the human system via preclinical validation of putative targets in a stateoftheart human vascularized bmonchip platform in conclusion this research proposal will uncover essential molecular mechanisms regulating stem cell niche dynamics in normal and pathological conditions provide a thorough understanding of the molecular and cellular plasticity of bm ecs and will result in innovative strategies to ameliorate aml clinical treatments
|
boosting the adoption of ultrashort pulsed laser large scale structuring with an agile dexterous and efficient manufacturing platform
|
operatic will develop a highly efficient and modular manufacturing platform to boost the adoption of highpower ultrashort pulsed lasers as a sustainable alternative to current surface processing the operatic open interoperable and expandable architecture will tackle the industrial entrance barriers of laser microstructuring of large 3d partsoperatic provides the required productivityquality through different developments i combination of advanced optical modules for beam transport and manipulation ii dexterous and precision robotic manipulator iii aienhanced process planning and adaptability operatic proposes a modular and automated routing of optical components guaranteeing versatility and replicability ie beam delivery polarization maintaining fiber management dynamic control beam shaping and metrology novel optical setups for product process monitoringon top of that operatic will develop a system architecture for the upscaling of uspl machines to large envelope and complex trajectories driven by a novel rami40compliant controller merging dexterous manipulation with high level cnc motion accuracy and full synchronization of motion laser process and quality control finally operatic proposes an i40compliant platform for systematic data exchange and integrated bidirectional communication automationml and opcua standards between real environment and its digital representation this endtoend seamless connection enhances a machine intelligence framework for the definition of zero defect manufacturing strategies empowered by ai and realtime monitorization and control for process optimisationa consortium of 4 top research institutions and 7 laser sector industry partners backed by 2 adoptionoriented partners will demonstrate operatic potential on relevant and high impact largescale usecases by 4 industrial endusers in the automotive aeronautic lighting and white goods sectors
|
sleep genes and circadian rhythm in dementia prevention
|
changes in sleep patterns are common among people with dementia however why short 6hrs or long sleep 9hrs duration is less favorable for dementia remains unknown given that approximately 46 44 of variability in sleep duration is explained by genetics it is pertinent to consider genetic influences when understanding the mechanisms contributing to sleeprelated risk for dementia in addition to sleep there is growing interest in the relationship between circadian rhythms the 24hour cycles of body dementia links between alzheimers dementia and the circadian system are suggested by common observations that an early symptom of alzheimers dementia is fragmented sleepwake patterns with increasing nighttime activity and daytime naps even among individuals who are cognitively intact altered circadian rhythms of motor activity have been linked to amyloid pathology the hallmark of alzheimers dementia there is some evidence linking weakening circadian rhythm to dementia yet it is not clear whether disruption of clock contributes to incidence dementia in clocked i will use data from the swedish twin registry with over 20 years of followup the largest twin registry in the world to assess if sleep polygenic risk score influences the risk of incident dementia overall alzheimers vascular examine whether differences in dementia risk are influenced by a genetically predicted sleep or sleep driven mainly by nongenetic factors ie environmental lifestyle factors using accelerometry data on around 100000 participants from the uk biobank data i will assess the relation of accelerometerassessed circadian rhythmicity with incident dementia quantify dementia risk stratified by sex ethnicity socioeconomic status shift work lifestyle factors metabolic status and determine whether a risk score consisting of circadian factors ie circadian syndrome is a more accurate predictor for dementia than existing risk scores
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.