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highperformance millimeterwave and terahertz components based on spoof surface plasmon polaritons for nextgeneration communications
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the millimeterwave mmwave and thz frequency bands hold immense potential for enabling ultrafast data transmission and unlocking unprecedented bandwidth capabilities but the rf components and circuits at these high frequencies suffer from relativelylarge insertion losses and manufacturing difficultyinaccuracy therefore this entails researching into a fullynew type of transmission lines able to mitigate the high insertion losses and alleviate fabricationtolerance issues of rf components this mitcom project aims to explore and develop new spoof surface plasmon polariton sspp transmission lines for the design of mmwave and thz components with low insertion losses and their applications in nextgeneration wireless communications specifically the overarching aim is to obtain ssppbased mmwave and thz bandpass filters and multiplexers with low losses low interference high fabrication tolerance ease of manufacturing and integration firstly a new type of planar halfspaced sspp transmission lines for waveguide and onchip application scenarios will be proposed and their design methodology will be developed to balance loss ease of manufacturing and crosstalk issues serving for eplane waveguide and onchip filter design then the strategy for different filter specifications and tolerance levels will be analyzed in the steps of modeling and implementation through particular manufacturing technologies based on the design methodology and strategy a series of eplane waveguide and onchip filters will be manufactured for validation and industry applications finally based on the newlyconceived planar halfspaced sspps diplexers and triplexers will be also designed characterized and fabricated the outcomes of the mitcom project will contribute to the realization of costeffective mmwavethz filter and multiplexer products that potentially increase company profits and propel growth of the 5g6g communication technology
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thermalization in circuit quantum thermodynamics
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thanks to advances in micro and nanofabrication techniques microwave engineering and cryogenics quantum technology is a fastgrowing field of science and industry with great expectations for societal benefits a quantum bit qubit is one of the central elements in the presentday quantum science but most importantly in future quantum information processing despite tremendous progress in improving the coherence of qubits almost a millionfold improvement in 30 years in case of superconducting circuits they still have to cope with different loss and decoherence mechanisms and they are vulnerable to influences from their environment which can disrupt and destroy quantum information with the progress in ultrasensitive nanoscale bolometry in the field of circuit quantum thermodynamics cqtd and the intense studies of superconducting circuit quantum electrodynamics cqed as one of the leading technologies for the realization of a universal quantum computer a combination of the two technologies provides a unique platform for studying thermalization and decoherence of eg a superconducting qubit in the presence of different environments on the fundamental side the goals of the project are in understanding thermalization of open and closed quantum systems formed of superconducting qubits josephson junction arrays and transmission lines as opposed to true dissipative baths formed of onchip resistors on the practical level mesoscopic heat baths in form of calorimeters will be developed by implementing crosscorrelation thermometry towards wideband detection of single microwave photons on the technological side i will advance my skills to advanced measurements of superconducting qubits and crosscorrelation detection of temperature during the outgoing phase of the project in us chicago caltech seattle and bring this expertise back to my host laboratory in finland
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surface and interface phenomena in sustainable energy storage systems
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energy storage systems are a crucial part to enable the transformation of our current economic system into a more sustainable one to balance the fluctuating nature of renewable electricity production from wind and photovoltaics there are many potential means of energy storage that differ in their storage capacity and duration such as batteries or redoxflow batteriesa common factor in all these systems is the importance of processes on surfaces and interfaces that control the involved chemical reactions and physical processes to improve the current and develop novel energy storage systems detailed understanding and insight about these surface and interface processes is required the proposed doctoral network will gain insight into these highly relevant surface and interface phenomena advanced analytical techniques will be utilized to directly probe chemical and physical processes relevant for the respective energy storage systems modelling and synthetic approaches will complement the understanding of these processes and allow the development of advanced materials and components for energy storage systemsthe gained knowledge will be directly applied on real world energy storage systems provided by the involved industrial partnersas these approaches are highly interdisciplinary the new generation of researchers has to be trained to excel in such complex research and industrial environments the proposed doctoral network will enable the phd candidates to combine the most advanced scientific techniques regarding analysis modelling and synthesis with the requirements of modern industry in the dynamic field of energy storage systems they will develop a deep scientific understanding of surface and interface processes and also the systemic knowledge to apply their skills in a broad range of industrial environments
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renewable and environmentalsustainable kit for building integration
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the reskin project aims at developing an integrated and multifunctional system for energy retrofit of existing buildings organised in two main subsystems roof and faade combined with the buildings hvac system the roof is equipped with a hybrid photovoltaicthermal system which produces electricity and heat and at the same time thermally and acoustically insulates the slab beneath electricity from retrofitted photovoltaic modules powers the buildings loads which interacts with the grid and ev charging stations heat is used by a heat pump for heating and hot water preparation solar modules form the outer skin of the roof and replace traditional materials such as tiles and sheets through a special treatment they can take on different colours depending on the aesthetic and architectural identity of the buildingthe faade is a thermal cladding with selfsupporting panels and biobased insulation optimised for quick assembly without scaffolding inside which the wiring for the new installations and earthquake sensors are housed retrofit techniquescomponents of existing windows are also included both the roof and the faade are particularly resistant to weather and extreme climatic phenomena as they use materials that are more resistant and waterproof than traditional onesthe hvac system consists of a solarassisted dc airwater heat pump connected to smartfancoils which are designed to be connected to the buildings heating piping but can provide both heating and coolingthe whole system is designed according to a circular economy logic using mostly recycledbiobasedrepurposedrefurbished materials and is supported by a lifecycle cloudbased dss and energy management tool in order to maximise energy performance while reducing environmental impactsthe system can be applied all over europe as it provides renewable energy and participates actively and passively in the energy performance of buildings both in summer and winter
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the care wave and the future of the baby boomers and their children
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the baby boomers are in the process of retiring most are between 60 and 65 when they retire and almost 80 selfassess their health as good a huge number of research projects has analyzed retirement decisions and the impact of this pension wave on the transformation of pension systems in the ageing societies in europe and elsewhere there is no lack of pension finance projections and policy advice for pension reforms and their socioeconomic effects including active ageing and the role of elder citizens in transforming our economies into silver economiesmuch less is known about the second great transformation that will follow the pension wave in the mid2030s the health of the baby boomers will have deteriorated and many in these large cohorts will be in need of formal andor informal longterm care this care wave will transform two generations the baby boomers in need of care and their children who may supply care it will have significant implications for labour supply especially for women saving behaviour and therefore for productivity economic growth and its inclusiveness the overarching objective of bbfuture is to make a concerted effort to understand the size and the implications of the care wave on economic and social outcomes to appreciate the quality of this second ageingrelated transformation and to develop policy recommendations for advance planning on the eu and ms levels
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boosting female entrepreneurship through joint services and activities
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the 24month womenture project aligns its efforts with the european commissions objective to create interconnected inclusive and more efficient innovation ecosystems across europe that draws on the existing strengths of european national regional and local ecosystems and pulls in new less wellrepresented stakeholders and less advanced in innovation territories to set undertake and achieve collective ambitions towards challenges for the benefit of the society including green digital and social transitions the overall objective of the project is to empower innovation agencies and accelerators to generate and embed new joint services and activities into their initiatives to boost female entrepreneurship and women innovation in the participating ecosystems the consortium brings together innovation agencies and accelerators from strong moderate and emerging innovator regions with the aim to support women innovators spread the entrepreneurial mindset present them the already existing initiatives of the partners projects and networks dealing with women innovators and connect each other through the delivery of its activities cocreation codesign coassessment capacity building business support programme innovation ecosystem hub creation the project will result in enhanced connections strengthened and more effective capacity of innovation ecosystem actors improved visibility and increased involvement of women innovators in innovation initiatives towards economic development and growth
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xverter celllevel controlled battery system enabling software defined power
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to meet the goal of limiting global warming to below 2c energy storage capacity must increase from 140 gw in 2014 to 450 gw by 2050 currently only 34 percent of globally generated electricity is stored by utilitieshydrogen fuel cells while suitable for centralized and longterm storage involve multiple conversion steps and infrastructure challenges battery energy storage systems bess are often more efficient especially for shortduration energy storage however conventional bess systems face limitations such as high conversion losses fixedstring cell connections leading to premature battery failure and limited scalabilityblixts xverter addresses these challenges with softwaredefined power conversion based on celllevel control technology this innovation enables bess to generate ac sine waves directly from the battery pack significantly reducing energy losses bypassing weak cells and extending battery lifespan by up to 80 the technology is adaptable to all battery chemistries suitable for various applications including secondlife batteries liion supercapacitors and more the modular and scalable design caters to diverse capacities and customer needs from critical infrastructure backup power to gridscale applicationsthe project aims to optimize the prototype design control software and producetest the bess compliance and certifications for various applications will be obtained and an initial software platform for endusers and stakeholders will be developed stakeholder feedback during bess demonstrations and field trials will inform further optimization and lead to largescale commercializationstrong letters of support from key stakeholders validate interest in supporting the project and beyond blixts strengths lie in its motivated founders and team a proven track record of delivering disruptive innovations a robust ip portfolio and recognition from industry metrics and partners
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reducing nutritionrelated noncommunicable diseases in adolescence and youth interventions and policies to boost nutrition fluency and diet quality in africa
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noncommunicable diseases ncds are a major public health problem resulting in over 70 of global deaths each year
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myelin membrane in molecular detail
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myelin plays a critical role in rapid action potential propagation and support of neuronal metabolism disruptions of its formation lead to severe neurodegenerative conditions with multiple sclerosis ms ranking as the most prevalent demyelination disorder in the central nervous system cns the multiple sclerosis international federation estimates that around 29 million individuals worldwide are affected by ms in 2023 and its prevalence is increasing yearly it is well established that myelinspecific membraneembedded and membraneassociated proteins are essential for wrapping the oligodendrocyte membrane around the axons forming the tightly packed membrane multilayers constituting the myelin sheath while the molecular identity of these proteins is known there is no highresolution structural information for any of the fulllength cns myelin proteins and it is unknown how these proteins interact among themselves and with the surrounding membrane to form the myelin sheath myemembrane seeks to throw structural insight on the myelin sheath assembly by visualizing principal cns myelin membrane proteins in a lipid environment at high resolution and to investigate the interplay between myelin proteins and the surrounding membrane using cuttingedge biophysical techniques unravelling the structural basis of myelin sheath formation is crucial for understanding myelin disorders and for exploring new research avenues including the development of new treatments endowing myemembrane with farreaching scientific and societal impact
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brownian motion near soft interfaces
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soft and wet contacts are ubiquitous across scales from geology to physiology and are crucial for engineering furthermore many processes of physics and biology at small scales are governed by the mobility of microscopic entities in soft and confined environments with the aim of reaching specific targets interestingly an emergent elastohydrodynamic ehd lift force was theoretically predicted recently for an immersed object moving near an elastic wall an active community including the pi has started to explore this striking effect with various deterministic models and experiments showing its relevance for nanoscale and biomimetic systems in this context and moving beyond the deterministic the pis central claim is that such ehd effects can be spontaneously triggered by thermal fluctuations the result would be an original migration scenario in complex and confined environments with enormous implications however studies are scarce on the topic the ambition of emetbrown is thus to address this challenge at the interface between two mature fields by solving a fundamental problem involving both continuum and statistical mechanics brownian motion near soft interfaces the three objectives are to reveal explore and harvest the signatures of such motion paving the way towards the future design of methods for particle transport surface patterning confined reactions and nanorheology these objectives will be reached using a combination of experiments theory and numerics domains in which the pi has extensive experience emetbrown involves three core experimental setups free colloids optical trapping and atomicforce microscopy three core theoretical models soft lubrication stochastic theory and langevin simulations and three exploratory tools microfluidics suspension rheometry and molecular dynamics these complementary methods will be employed through four work packages covering various viscous hard soft materials as well as applied flow
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regenerative engineering of living autologous interfaces
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relai will design and exploit a toolbox of innovative bioelectronic technologies and surgical constructs that will enable new possibilities in neural interfacing and revolutionise the way we transduce information to and from the human body this new class of living bioelectronics will leverage bespoke electrode arrays and electrical stimulation paradigms to guide neural regeneration within autologous surgical constructs in vivo the reinnervated constructs are hypothesised to form living highresolution interfaces that will enable precise modulation of somatic and autonomic functions via injured and intact nerves this innovative class of biohybrid interfaces will enable a broad array of applications ranging from the treatment of chronic conditions such as diabetes to the enhanced operation of advanced neuroprostheses and the realisation of supraphysiological sensing
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multilevel orders of corruption in central asia
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corruption has become a buzzword in both academic and policy debates over the last three decades the initial view that corruption greases the wheels of economic growth in the newly independent states of africa and asia has lost its validity in the light of the current evergrowing global coalition against corruption spearheaded by transparency international and the world bank despite the unrelenting global anticorruption efforts one thing seems clear there is no such thing as a remedy to this cancer in the light of the obvious failure of global anticorruption initiatives there has been a growing call to rethink the existing approaches arguing for the necessity to understand better what corruption is why it occurs and what we can do to stop it mocca is a research and staff exchange programme intended to contribute to the global and national efforts of understanding and counteracting corruption by conducting research on the multilevel orders of corruption in five countries in postsoviet central asia kazakhstan kyrgyzstan tajikistan turkmenistan and uzbekistan this will enable the mocca team to 1 gather original empirical data based on research solidly grounded in fieldwork on the interplay between international law norms national laws and local legal cultures and informal norms in central asia and their implications for understanding corruption and its societal effects 2 engage with and situate our research in relevant theoretical debates and thereby advance scholarly debates on anti corruption by developing new conceptual methodological and comparative approaches to study and understand it and 3 provide strategic intelligence for eubased political and economic actors interested or already working in the region and to inform international organisations and decisionmakers in the eu and central asia on ways to combat corruption and improve the business and investment climate the rule of law and governance in the region
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new methodologies for automated modeling of the dynamic behavior of large biological networks
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in silico models aim to capture and elucidate the complex and emergent interactions of biological systems with the goal of expediting research and potential clinical translation for example ordinary differential equation ode models of toxin and drug transport are being developed to bring safer therapies to chronic kidney disease patients despite recent progress these cuttingedge odes only model transport in steady state and remain limited regarding the amount and complexity of dynamic transport mechanisms as it is often not clear which kinetic relation is most suitable this limitation is due to the manual and laborintensive approaches to construct the odes which critically hinder their application in quantitative toxicity assessment in key industrial settings like drug development in automathic i will leverage and combine my expertise in mathematical modeling and machine learning to develop an integrated framework for automated ode structure identification parameter estimation and model evaluation focusing on cell transport and signaling which is the timely leap forward needed to create large dynamic models and transform the field i will test and illustrate the capabilities of the developed framework by exploring the dynamics and regulation of proximal tubule pt toxin and drug transport i will use the dynamic pt model to define novel therapeutic regimens that minimize toxin accumulation in combination with a stateoftheart in vitro setup to measure the essential time series data required for model calibration and validation the anticipated outcomes of automathic are 1 a nextgeneration integrated framework for automated model structure identification and parameter estimation that will become the new standard for the creation and interrogation of large dynamic models of cell transport and signaling 2 crucial knowledge about pt transport and metabolism 3 a dynamic pt model to optimize nephrotoxicity protocols drug dosing and screening
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10 angstrom cmos exploration
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the objective of the 10ce pthe objective of the 10ce project is to explore and realize solutions for the 10 cmos chip technology its consortium covers the entire value chain for manufacturing of the cmos chips in the 10a node that is from chip design to lithography to process technology and finally chip metrology essential parts of hardware software and processing technology are developed pushing the boundaries of semiconductor design and manufacture to enable the new node and keep moores law alive the 10ce project is built based on the following four pillarslithography equipment asml and expert euv partners zeiss fastmicro iom plasma matters tno tue university of twente and vdletg will increase key performance indicators of the euv tool to enable smaller pitches and increase yieldincrease sustainability of the euv tool both during production as well as increasing the times a module in an euv tool can be refurbished chip design and mask optimization imec with the involvement of expert imaging cad and ip design partners arm asml and siemens will assess the impact of the introduction of 3d mcfet on chip design in terms of power performance and areadevelopment of new computational lithography solutions to print 10 cfet structures to improve imaging by next generation mask designprocess technology as the ultimate device for logic the cfet architecture is proposed and imec and expert partners coventor evg ibs intel jsr lam recif tel zeiss and wooptix will demonstrate a fully functional monolithic cfet mcfetincrease sustainability of the chip manufacturing process across the manufacturing process and including resist material developmentprocess characterization applied materials and expert partners thermofisher nova kla and bruker will explore and realize high throughput and sample density per wafer for the analysis characterization for 10 3d cfet devices interconnect and materials
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safe healthy and environmental ship recycling
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ship recycling refers to the disassembly of a ship in recycling facilities as well as the storage and processing of these materials to reuse them the ship recycling industry enables the reuse of raw materials for industrial purposes and thus is fully in line with the european circular economy action plan and green deal objectives yet in addition to workrelated diseases due to toxic substances unacceptably high levels of fatalities and injuries at current shipbreaking yards makes ship recycling one of the most dangerous occupations in the world ilo 2015besides due to the lack of proper waste management toxic waste from shipbreaking contaminates the coastal areas and exposes the workers to hazardous substances although international regulations exist to reduce and prevent the adverse effects of ships on human health and the environment imo 2009 unep 2011 regulation eu no 12572013 improving the safety and health of workers and stopping the detrimental impact on the environment still remain major challenges of the sectorthe main objective of sherec is to enable the involvement and adoption of innovative robotics data and ai systems into the ship recycling industry to significantly improve the occupational health and safety conditions in this industry and to prevent contamination of hazardous materials both at occupational and environmental levels specifically sherec will 1 semiautomate the preparation process in ship recycling using an aipowered drone inspecting the interior of the ship to locate hazardous materials on the ship 2 create an automated ship recycling plan using a digital twin of the ship and aibased planning methods and 3 automate the cutting and paint removal processes in ship recycling process using two innovative mobile robotic systems that can work autonomously or via teleoperation
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innovative blockchain traceability technology and stakeholders engagement strategy for boosting sustainable seafood visibility social acceptance and consumption in europe
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current seafood traceability tools and services have the potential to take advantage of novel blockchain technologies to obtain a wide range of data making sustainable seafood practices more visible to consumers sea2see project will fill in existing seafood traceability gaps through development of an innovative endtoend blockchain model and professional and consumer applications to increase trust and social acceptance of sustainably fished and farmed seafood the project will provide technological solutions to answer the need of a valuable source of data collected throughout the whole seafood value chain verified and covering inputs from diverse stakeholders for that purpose a specific focus will be put on active commitment of stakeholders and real empowerment of consumers through the implementation of societal and sectoral strategies for cocreation communication and awareness raising
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bauhaus bites positive food environments fortified with naturebased solutions and new european bauhaus
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the project will deliver urban food system transformation via bauhaus bites bb food environments cocreated and demonstrated in 7 cities at different levels of societal readiness their transferability discussed with sister projects and europeanglobal networks and the results summarised in a playbook for broad adoption bauhaus bites food environments are urban and periurban ecosystems that commit to implementing sustainable healthy diets amplified by the new european bauhaus and fortified with naturebased solutions ensuring that the transformed food environments of tomorrow are sustainable inclusive and beautifulby merging the key perspectives of european and global strategies such as the farm to fork and food 2030 strategies the planetary health diet and the planetary health diets with the new european bauhaus values and principles bauhaus bites offers a unique approach not yet seen in food system transformation projects that will reimagine these food environments together with local culturally diverse communities customised to meet their needs and anchored in social meeting spaces that carry meaning for them the project will cocreate bb food environments in 3 trailblazers birmingham fundo zagreb and 4 twins murska sobota ostend palermo sarajevo with different geographies sizes demographic challenges and societal readiness boost mutual learning through a community of practice document their added value with sciencebased indicators to inform highlevel policymaking test them for transferability with europeanglobal networks and summarise the learnings guidelines methods and examples in a playbook the bb approach will be based on inclusive participation and cocreation including city and regional authorities community and businessdriven initiatives and inhabitants and end users of the food environments
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projecting the fate of arctic and alpine ungulates how past climate and harvesting shaped genetics and demography
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conserving biodiversity urgently requires the integration of knowledge across ecologicaltime scales and disciplines aaungulates will fulfil such major ambition developing an innovative framework joining palaeoecology to evolutionary demography by extracting invaluable knowledge from millennia of natural history and detailed demographic data this project will provide advances in predicting species persistence under rapid global changes specifically the project will study 1 the effect of climate and harvest on effective population sizes of arctic and alpine ungulates at historical using subfossil genomics and 2 contemporary using genomics and demography timescales to 3 project their population viability under credible climate scenariosto achieve these novel goals i propose a pioneering approach linking stateoftheart genomics from ancient and modern specimens to individualmonitoring programs to maximize societal impacts the research focuses on charismatic ungulates sharing histories of huntinginduced bottlenecks and inhabiting biomes warming the fastest on earth these unique empirical datasets will allow theoretical advancements by identifying common genetictodemography processes with important insights on how population viability is tied to low genetic diversityto undertake this integrative endeavor a twoway transfer of knowledge will be crucial between the beneficiary universit savoiemont blanc usmb france and i in g yannics expert group i will learn about alpine ecology and paleogenomics and in turn will bring knowledge of arctic ecology and demographic biostatistics a strong collaborative team from 9 institutions in 4 countries gathering eminent specialists in key aspects of aaungulates will further enrich my network and skills the highquality outputs planned supplemented by the diverse earlycareer programs at usmb will give a springboard to become an independent expert in multiscale evolutionary demography
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toward efficient and environmentallyfriendly cooling using active electrocaloric regeneration
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cooling accounts for 17 of total global electricity consumption vapor compression cooling dominated the markets whichuses refrigerants that can leak to the environment and exhibits low efficiency by contrast cooling based on an electricfielddriven change in temperature of certain materials ie the electrocaloric ec effect promises an environmentallyfriendlytechnology with high efficiency however three key obstacles have prevented ec cooling from becoming commerciallyrelevant small temperature span low fatigue life and high applied voltagethis project has an ambitious goal of gaining insight into a regenerative ec cooler which will enable the design andfabrication of the first regenerative ec device exhibiting a large temperature span with long fatigue life performance targetsinclude a temperature span of 20 k a fatigue life of 10000 cycles and a low applied voltage the research is organized intothree work packages 1 advanced material characterization 2 highfidelity system modelling and 3 demonstration of ahighperformance demonstrator to achieve this challenging goal a strong collaboration will take place between threeleading institutions ie the technical university of denmark the university of cambridge and the university of barcelonathe applicant is currently at forefront of international advances in developing regenerative cooling technologies withinternationally recognized awards 24 peerreviewed publications and 11 innovation patentsthe project will demonstrate a new concept of a robust high performance electrocaloric cooler which is expected totransform the current cooling technology to the new one that is environmentally friendly and efficient a timely award of themarie skodowskacurie fellowship will provide the applicant the necessary resources and access to expertise to makerapid progress in this emerging research area and become an independent researcher ready to compete globally
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chronology of the norse transatlantic colonies and territories
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for ten thousand years the world was divided in two almost all human societies belonged to either the old or the new worlds amid this consummate isolation the two worlds followed their own cultural and ecological trajectories the loop was finally closed when the norse arrived in the americas in 1021 ce however the story of this closure ironically remains one of the most significant gaps in our knowledge of the past this project addresses the timing duration geographical extent and lasting significance of this period of first contact using the newly developed tools of spike radiocarbon dating and ancient dna provenancing current understanding of the norse transatlantic expansion will be both tested and extended data of unprecedented precision will cast the history of greenland into sharp relief allowing fresh insights to be gained on the role of conflict climate and trade in the ultimate abandonment of the colony furthermore by analysing artefacts on either side of the atlantic the true extent and temporality of the norse presence in the new world will be unveiled drawing all the new evidence together contact will be able to trace the story of the period as it has oscillated down the centuries between fact and fiction in so doing it will establish a framework for reanalysing the earliest connections between the old and the new worlds
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program exchange for chiral symmetry
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exqiral is a proposed 4year exchange program between the max planck society icfo barcelona the weizmann institute of science israel university of pisa and mit usa the researchers exchange will be based on preexisting scientific program between these partners and will provide the researchers with a collaborative environment to address fundamental questions in the field of topology chirality twistronics or quantum chemistry amongst others many fundamental breakthroughs in science will result from the development of new techniques in this synergetic program exqiral will develop specialized tools for exploring the chiral nature of matter as well as fabricating novel tuneable devices that take advantage of the unique properties of chiral matter exqiral will bring tremendous added value not only to the research programs that it will catalyze and incentivize but also in the training and mentoring of young scientists to carry out research that is bold of high risk and that will lead to the greatest impact on the scientific world and beyond exqiral will create a range of structural components that are designed to promote risk taking both in scientific exploration as well as in the translation of research findings to impact on society a major mission of exqiral will be to foster the careers of the most brilliant young scientists at the participating institutes and especially to create structuexqiral is a fouryear staff exchange multidisciplinary program between 4 academic partners of four european countries icfo spain weizmann israel uni pisa italy mpg dresden and one thirdcountry mit usa this collaboration is based on an existing program and established collaboration amongst these institutions the combination of expertise from the five institutes can benefit a joint research program by offering a comprehensive and synergetic approach to studying novel quantum and topological materials and unresolved mysteries like the ciss effect
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coupling biogeochemical analysis environmental dna and ecological network analysis of sediment cores to reconstruct environmental history and ecosystem changes in posidonia oceanica meadows
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posidoniarxiv combines multiple disciplines to reconstruct ecosystem processes dynamics and change through time in posidonia oceanica meadows in spain p oceanica is an iconic seagrass in the mediterranean basin forming extensive meadows and dense mats which work to stabilise sediments and form a millenary sedimentary archive while providing habitat for an abundance of marine life p oceanica meadows contribute to global change mitigation and adaptation by sequestering pollutants including co2 and reducing coastal erosion while enhancing biodiversity by providing habitat and breeding areas for marine life including commercial species however seagrasses in general and p oceanica in particular are in decline due to anthropogenic disturbances such as climate change pollution and landuse change these meadows sustain the livelihoods of coastal populations and are located in coastal areas throughout the mediterranean in particular p oceanica inhabits sheltered embayments that also constitute key areas of settlement by ancient civilisations until present posidoniarxiv combines environmental dna biogeochemical analysis and ecological network analysis to understand the historical changes in poceanica meadows firstly sediment cores will collected at sites of high and low anthropogenic disturbance and biogeochemical analysis will be conducted to determine key periods of human or natural disturbance this will inform sampling and edna analysis to reconstructed historical changes in biodiversity at these sites furthermore the edna data will be used for ecological network analysis over millennia timescales to understand biodiversity change and identify mechanisms of resilience in this environment overall posidoniarxiv will strengthen management and restoration targets for poceanica environments and contribute key knowledge to historical reconstructions of whole ecosystems
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fluctuations in continuum and conservative stochastic partial differential equations
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fluctuations are ubiquitous in real world contexts and in key technological challenges ranging from thermal fluctuations in physical systems to algorithmic stochasticity in machine learning to fluctuations caused by smallscale weather patterns in climate dynamics at the same time such complex systems are subject to an abundance of influences and depend on a large variety of parameters and interactions a systematic understanding of the interplay of stochasticity and complex dynamical behavior aims at unveiling universal properties irrespectively of the many details of the concrete systems at hand its development relies on the derivation and analysis of universal concepts for their scaling limits capturing not only their average behavior but also their fluctuationswe propose to analyze the class of conservative stochastic partial differential equations spde as such a universal fluctuating continuum model and unveil its mathematical analysis as a fruitful field for the discovery of new mathematical structures and methods the key challenges targeted in this proposal are 1 wellposedness of singular conservative spdes 2 singular limits for supercritical conservative spdes 3 stochastic dynamics for conservative spdeswe aim to approach these challenges by a novel combination of recent scientific breakthroughs in the fields of strongly nonlinear conservative spdes and singular spdes we thereby intend to advance the highly active and productive field of singular spdes which has inspired striking mathematical progress in the last decadethe analysis of conservative spdes conjoins several contemporary fields of analysis and probability singular spdes nonlinear pdes kinetic theory supercriticality and stochastic dynamical systems we are therefore confronted with an interplay of stochasticity irregularity and nonlinearity posing new challenges and going far beyond established methods
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translation in cellular context elucidating function organization and regulation with nearatomic models in whole cells
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translation the fundamental process of protein synthesis catalyzed by ribosomes has been extensively characterized from a biochemical structural and mechanistic perspective however how exactly the translation machinery operates as an interconnected system of millions of ribosomes in cells is poorly understood within the cell ribosomes associate with a multitude of regulatory proteins forming a variety of specialized complexes and distributing across cellular space in a manner that depends on cell state what is the specific composition of those complexes their significance and their functional role how are they defined and regulated by subcellular compartmentalization how do they change in response to cellular stress our transform synergy team brings together experts in method development for incell structural biology and the biology of translation to allow us for the first time to attack these fundamental problems building on our prior achievements we aim to synergistically develop novel methods of cryoelectron tomography with imaging across scales in conjunction with crosslinking mass spectrometry and integrative structural modeling for nearatomic structure determination directly in cells transform will determine the ribosome structural and functional states across the translation cycle in human cells following distinct 40s 80s and disomal particles 80s80s in and out of polysomes and across different protein synthesis regimes we will uncover structural and compositional changes and regulatory mechanisms across cellular space in adaptation to perturbations by stressors and during viral infection our model systems will span from single cells to organoids transform will provide a detailed and comprehensive incell map of the essential process of protein synthesis while delivering innovative methods for the nextgeneration of incell structural biology
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deconstructing hypothalamic neurocircuitry architecture and function in metabolic control during health and disease
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understanding the exact nature of cnsdependent regulation of body weight has become of utmost societal importance as we are witnessing an everincreasing number of overweight and obese subjects who exhibit a predisposition for a plethora of obesityassociated diseases such as type 2 diabetes mellitus cardiovascular diseases and certain types of cancers however despite the tremendous advances made in defining the neurocircuitry basis underlying the central control of feeding and metabolism critical open questions still remain for example how can we reliably identify the exact anatomical localization of the recently identified molecularly heterogenous cell types in the hypothalamus what are yet unknown energy state or food cueregulated neuronal cell types and what is their functional contribution to energy homeostasis which are yet unidentified neurocircuits critical for the initiation of adverse metabolic effects upon highly palatable food consumption and what are the lipotoxic species accumulating in energy stateregulated neuronal cell types upon obesity development the proposed work program will employ stateoftheart technologies in modern molecular systems neuroscience and mouse genetics and will focus on the following four key aims1establishment of a highresolution spatial transcriptional map of the murine hypothalamus2identification validation and functional characterization of novel hypothalamic neuronal cell types activated during fastingfeeding transitions and upon sensory food perception3discovery of novel hypothalamic neurocircuits activated during obesity development4assessment of cellintrinsic lipidomic changes in metabolism regulatory neurons during obesity developmentthus the proposed work program will not only advance our fundamental understanding of the cnsdependent regulation of metabolism but could also open up new channels of drug discovery for tackling obesity and obesityassociated metabolic diseases
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renewable hydrogen for inland waterway emission reduction
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the main aim of rh2iwer is to create a solid basis for the acceleration of hydrogen fuel cell powered vessels in inland waterway shipping by demonstrating six commercially operated vessels these vessels are of varying lengths and types 86m 110m and 135m container bulk and tanker vessels with installed power ranging from 06 to 2 mw the project will also work with standardization of containerized fuel cell and hydrogen solutions with the demonstration standardization work and multilevel analysis combined with vigorous dissemination and communication measures rh2iwer project will create a basis on which the shipping industry can significantly reduce their environmental footprint and remove emissions from their entire fleet in the future the inland waterway fleet comprises a total of more than 15000 vessels and the vessels within rh2iwer are representative of the typical dry and liquid cargo vessels in the rhine and danube fleets amounting to 12800 vessels or roughly 80 of the inland waterway fleet the lessons learned from developing fuel cell and hydrogen solutions for the vessels in this project could be applied more or less directly to these vessels which would then immediately reduce the ghg emissions from these ships to zerothe consortium includes 14 european partners with five shipowners future proof shipping theo pouw vt shipping dfds and compagnie fluviale de transport with its affiliated entity sogestion the shipowners are supported by two of the main maritime fuel cell manufacturers ballard europe and nedstackl as well as world leading gas company air liquide and its affiliated entities air liquide belge and lair liquide sa lastly highly respected knowledge institutions vtt stichting projecten binnenvaart and university of genova with their affiliated entity h2boat will assist the companies in successful deployment as well as the dissemination replication and exploitation of these demonstrations and technologies
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unconventional principles of underwater wave control in the subwavelength regime
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the growing interest in marine renewable energy and oceanrelated human activities are the main causes of an alarming increase of the noise level in the oceans and seas nevertheless the performance of underwater noise mitigation systems has since long been and still is limited by the fact that dissipation in linear systems is inherently poor at the subwavelength scale consequently a viable solution to attenuate underwater waves over low broadband and multiple frequencies does not exist yet poseidon aims to tackle the intrinsic reasons for such a scientific technological delay and declares an ambitious goal to develop a new class of metascreens allowing zerotransmission zeroradiation over low and broadband frequencies exploiting rather than avoiding complexities stemming from heavyfluidstructure interaction and exhibiting practical structural requirements such as being compact lightweight and efficient under hydrostatic pressureposeidon will take the risk of exploring two unconventional and groundbreaking approaches in the challenging context of extremely subwavelength underwater acoustics to design a new class of metamaterials allowing unprecedented low and broadband wave reflectivity and absorption1 antiauxetic underwater metamaterials exploring the intimate relationship between the microstructure and the macroscopic vibrational properties of a multiscale metamaterial immersed in a heavyfluid and exhibiting poissons ratios 052 topologically protected and impedance adapted underwater metamaterials assigning crystalline properties to noncrystalline materials by breaking precise classes of symmetries over multiple length scalesboth approaches are supported by the innovative assumption that 3 underwater wave control through metamaterials be already exploited by natureif successful poseidon will fill the gap in the knowledge of underwater acoustics and significantly advance the frontiers of bottomup material design
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fluxes at divergent plate boundary environments analyzed in time and space
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fluxbeats is a doctoral network in earth sciences it focusses on the material fluxes magmatic oreforming and environmental processes at divergent plate boundaries and explores how these relate to processes since the precambrian that formed the majority of the economic mined global metal deposits comprehensive training in field analytical and modelling skills will involve 12 european academic and 5 nonacademic partners and establish a unique training platform in interdisciplinary earth science research involving marine economic and structural geology geochemistry geophysics biogeochemistry geobiology petrology geodynamics and hydromechanics the programme includes 10 doctoral candidates in two scientific working packages from the earths mantle through the crust to the ocean fluxbeats targets geological and environmental processes from the present to the past and will investigate complementary processes in both submarine and subaerial environments the dcs will acquire a unique interdisciplinary intersectoral scientific and internationally transferable skillset preparing them to become europes highly demanded future leaders for responsible exploration and exploitation of mineral resources in the submarine and subaerial environment in a world of increasing demand of critical metals the dcs will develop novel integrated models of elemental transport oreformation as well as evolution of ecosystem changes at divergent plate boundaries through time overall fluxbeats will therefore provide an academic and nonacademic perspective on the fundamental processes that control the occurrence and quality of base and precious metal resources in high economic demand and the evolution of ecosystems through time and establish a basis for future responsible eu greenmining policies in the marine and terrestrial environment
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the four freedoms of the eu internal market is the free movement of persons more basic
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eufreedoms examines the philosophical underpinnings of the four fundamental freedoms of the eu single market the free movement of goods persons services and capital while the legal literature on the four freedoms is huge much less effort has been made to analyse the freedoms in philosophical terms philosophical debates have focused predominantly on the free movement of natural persons yet there are many interesting questions about all the freedoms how can we best interpret the rights protected by the freedoms which kind of justifications should be given of the four freedoms how are eu citizens benefited by having each of the freedoms how should we understand the relationships between the freedoms is there a hierarchy between the freedoms is the free movement of persons worthier of protection than the free movement of capital how should we handle conflicts between the freedoms and other values eg social rights eufreedoms is an interdisciplinary project that contributes to the political theory literature of the eu with an analysis of the philosophical foundations of the four freedoms which will contribute to shed light on the nature of the rights protected by the freedoms and hence also on the possibility of establishing a hierarchy between the freedoms arguing that the free movement of persons is more fundamental than the other freedoms indeed that it should be considered a basic right eufreedoms aims to shed light also on the way in which the four freedoms should be balanced with other considerations eg social rights there are many areas where eufreedoms can have considerable impact for example it can contribute to a better understanding of the shape that eu integration should take in the future and to better legitimising the four freedoms in the eyes of eu citizens
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cherenkov light for totalbody positron emission tomography
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the paradigm shift in medicine from the treatment of acute or advanced disease to very early diagnosis and even prevention in cancer as well as in personalized treatment puts more stringent requirements on positronemission pet imaging both in terms of sensitivity as well as specificity novel long axial pet scanners with an axial field of view that can be greater than 1m offer a very attractive solution to many of these challenges in particular if they are combined with the timeofflight tof pet technology the timeofflight resolution of pet scanners is limited by the timing spread due to delayed scintillation emission by using prompt cherenkov photons instead the coincidence timing resolution can be improved we propose to prove the feasibility of the above idea by combining a set of our breakthrough innovation steps latest advances in photon detection with large area fast photon detectors and in the lownoise fast timing electronics the pet detector that we would develop in the proposed project would allow for a construction of a pet scanner at a lower cost better performance and ease of handling if compared with the stateoftheart clinical devices if successful our technology will represent a major leap in the use of pet for cancer diagnosis staging restaging prodromal detection of neurodegenerative and cardiac diseases as well as treatment guidance and monitoring
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molecular materials for onchip integrated quantum light sources
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artemis proposes fundamental research toward the development of integrable single and entangled photon sources based on metallorganic molecular compounds the project is motivated by the urgent need for novel quantum sources with unprecedented versatility flexibility and performance this goal will be pursued by resorting to molecular materials based on transition metal andor lanthanide ions with organic moieties characterized by tunable linear downshifted emission as well as nonlinear optical properties enabling ondemand single photons and entangled photon pairstriplets generation such flexible and processable metallorganic materials will replace traditional quantum photon sources based on bulk inorganic crystals allowing for the direct integration of wavelengthtunable quantum sources on current devices the molecular quantum sources will be combined with suitable designed plasmonic supernanostructured cavities to achieve the highest optical enhancement the proposed progress will be gained through cuttingedge synthesis techniques and advanced characterization methods integrated with nanophotonics engineering strategies the devices and methods developed in this project will lead to photon sources with competitive performance in terms of coherence efficiency scalability and cost this will lead to a fundamental breakthrough in the development of quantum technologies paving the way to bring them out of the laboratory into the real worldthe achievement of the high riskhigh gain project goal requires an intensive research activity in different scientifictechnological areas achievable thanks to a multidisciplinary consortium and the right balance among the competitiveness of the expected results the degree of the technological innovation and future development the outcomes and targets are expected to lead european research at the forefront of the second quantum revolution thus contributing to europes position as a global leader in the field
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controlling spin properties of molecules with quantum fields abinitio methodologies for spin polaritons
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the goal of qedspin is to build novel ab initio techniques to reveal effects induced by quantum fields on the spin properties of molecules quantum computing and spectroscopic techniques are just two of the main fields that stand to benefit significantly from advancements in spin engineering a field that is currently at the science frontier both for experiments and quantum many body theory in this project i will propose new strategies based on strong lightmatter coupling to manipulate static and dynamical spin properties of molecules the mission of qedspin is to explore using advanced theoretical techniques the phenomena that arise when quantum fields interact with the electronic and nuclear spins of molecular systems and their implications in chemistry spectroscopy and spintronics in particular the proposed techniques will represent a significant step forward toward a better manipulation of molecular spin qubits used in quantum information and energy and memory storage they will also increase our current possibilities of control on the photochemistry of molecular systems the effects induced on the nuclear spins will bring to the formulation of a novel and more selective nuclear magnetic resonance technique the developed theoretical and computational techniques will provide differently from the previously applied model treatments new tools to quantitatively simulate spin properties of molecules combination of cavity quantum electrodynamics and accurate quantum chemistry methodologies will form the basis for the development of novel tools to interpret and design spin properties coupled cluster theory configuration interaction and density matrix renormalization group approaches will be used i believe that the results of qedspin will build the foundations for a new field of research cavity spintronics
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cnewtral smart comprehensive training to mainstream new approaches for climateneutral cities through citizen engagement and decisionmaking support for innovative governance and integrated planning
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achieving climateneutral cities is an eu priority yet faces many challenges because of the complex urban activities and the vast range of stakeholders involved the european commission has identified participative city governance and integrated urban planning as key enablers for driving climateneutral cities forward cities require enhanced capacity and ongoing support for implementation of climateneutral solutions and assessment of how they may impact different sections of society there is however a lack of highlyskilled highlytrained interdisciplinary researchers and professionals for this task which cnewtral aims to addresscnewtral is underpinned by five key thematics urban nature urban mobility built form energy circularity which are integrated through two crossscale research dimensions linked to drivers identified by the eu i citizen engagement public participation and ii city governance decisionmaking this provides a framework for individual research projects examining participation and decisionmaking for integrating naturebased solutions in urban regeneration active green just mobility transitions social acceptance of energy performance standards in buildings neighbourhoods social housing hydrosocial circular digital approaches in urban water management and nexuses among these each researcher will be trained in advanced participative methods and use of governance planning tools supported by digital technologies recognised by the eu as a priority but still underdeveloped within city planning processes researchers will be exposed to secondments in local authorities ngos or industry the program will provide a dynamic intellectuallychallenging interdisciplinary training environment attracting the best international graduate candidates and fosters an enthusiastic and innovative community of researchers effectively placed to advise on crosssectoral strategies for achieving climateneutral cities
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we care for those who care
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care workers are mainly women and migrants which makes the care sector an interesting field to verify the dynamics of segregation and exclusion that affect the labour market at the same time it is a challenging testing ground which allows to design and verify new measures to contrast discrimination and promote social inclusion eu institutions have included the care work sector among those sectors key to the future of european society and economy the covid19 pandemic has made even more clear the centrality of care work in modern societies but it also made more visible many critical issues affecting the working conditions of care workers such as the lack of adequate economic resources the workforce shortage the pressure put on care workers the risks for their wellbeing the underfinancing of social care as a consequence of the reorganisation and partial retrenchment of the welfare state the weaker bargaining power in the sector than in maledominated sectors the undervaluation of femaledominated jobs the prevalence of undeclared work in domestic care work patterns of discrimination in the sector on grounds of gender and nationality and the intersectionality between the twothis project proposal aims to investigate in a comparative and multidisciplinary perspective the working conditions of care workers and their perception of their working environment and dynamics and to develop suitable tools to improve job quality and contrast discrimination such as elaborating policy strategies to tackle the undervaluation of care work with particular attention to the key role that trade unions employers associations as well as equality and monitoring bodies can play designing training programmes to empower trade unions and family associations and employers reps to improve job quality in the sector setting up of a permanent observatory on care work which will implement a platform accessible to care workers in order to improve their rights awareness
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integrated holographic management map for safety and crisis events
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climate change is happening and the need for a higher performance crisis planningcommand tools and new methodologies arises from the increasing frequency and impact of a variety of natural hazards including floods earthquakes droughts landslides and wildfires that are responsible for dead wounded or displaced people and severe destruction and disruption of property and industry with clear impact on economy for years after the eventnatural disasters which can be related with the 1672 recorded disasters floods storms wildfires heatwaves in europe between 1970 and 2019 that took 159438 lives and impacted the economy in excess of 420m the objective of overwatch is to develop an integrated holographic management system for response recovery and mitigation of emergencies and disasters by enabling the authorities to quickly deploy and manage air water and ground assets and personnel through decision support tools integrated in an immersive and decentralized command platform this system will be supported by combining several services already offered by egnss and copernicus emergency management and security for example and has and sar with digital technologies artificial intelligence drones 5g augmented reality which will provide the required performance to make this system a valuable resource for citizen land and infrastructure protection
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providing computational insights into cardiac xenotransplantation
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we are at the dawn of a new age in medicine marked by the first pigtohuman heart transplant xenotransplantation has long been a dream for clinicians and now due to rapid progress in gene editing is becoming a reality to overcome immediate rejection barriers of immunity and infection have to be overcome however achieving longterm success requires a deep understanding of the physiological and mechanical challenges introduced by the anatomically dissimilar xenotransplants xenosim aims to address these challenges by providing fundamental clinical insights into the nascent field of cardiac xenotransplantation through the development and application of novel highresolution higherorder multiphysics simulation methods tremendous progress has been made in biomedical imaging nonetheless a multitude of physical phenomena relevant to xenotransplantation are not available for experimental observation in silico studies are uniquely placed to provide insights into the haemodynamic disruption caused by replacing a human heart with an anatomically dissimilar one xenosim is targeting the establishment of the first family of porcine cardiac xenotransplant models that can provide clinically significant insights into the haemodynamic compatibility of porcine donor hearts the impact of surgical approach and the consequence of pathologies to provide these novel insights requires new coupled simulation approaches accordingly the second goal of xenosim is to create a new class of monolithic finite volume fluidelectrosolid interaction methods which can provide predictions in clinically relevant timescales through the exploitation of hybrid cpugpu systems xenosim will establish the new field of computational cardiac xenotransplantation furthermore the novel numerical methods established by xenosim are expected to impact a broad range of fields well beyond the project end
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bulk rare earth free permanent magnets
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permanent magnets are essential components of an enormous amount of consumer and industrial products their production rises annually especially due to their use in fast growing green technologies such as electric mobility high performance magnets with a large energy product are usually based on the ndfeb material system the major components are rareearth elements which are listed as critical materials novel permanent magnets use the concept of magnetic coupling effects in course of the erc starting grant spdtum we have developed a new processing route to synthesize permanent magnets based on this concept the objective of this erc poc grant is to use this processing route and apply it to the mnbi system which represent a rareearth free alternative to the currently used ndfeb magnets as additional benefit the magnetic mnbi phase exhibits an increasing coercivity with rising temperature thus magnets based on mnbi will be especially wellsuited for high temperature applications we use highpressure torsion a severe plastic deformation method for processing which has the advantage that the key mnbi phase can be directly formed during processing coupled to a soft magnetic phase a high performance permanent magnet with an excellent energy product will be obtained so far this type of magnet has only been successfully obtained in limited volumes thin films powders with our processing route it is possible to synthesize magnets in dimensions with about 100000 times larger volume the novel mnbi permanent magnets will be characterized with stateoftheart methods in terms of their microstructure and magnetic properties the upscaling potential of the developed processes from laboratory to industrial conditions will be further critically evaluated these activities will be complemented by patent protection to facilitate commercialization and outreach to potential industry partners for the introduction of our novel method and new collaborations
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european advisory and extension networks on forestry
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foradvise will develop a european network of forest advisory organisations actors and networks to support the modernisation of the forestry sector and advance towards eu and national policy targets it will speed up knowledge flows increase the competences of forest advisors beyond traditional areas of advice and develop pathways towards a future forest knowledge and innovation system fokis in europe its ultimate goal is to advance towards more resilient multifunctional and productive forests in europe to achieve this foradvise creates a eu forest advisory network on forestry and animates an iterative knowledge sharing process combining national and international action and implements knowledge transfer pilots to adapt advisory practices to new contexts it develops training modules contextualising well proven approaches and materials delivering them through a mooc it develops a cost benefit analysis toolkit to increase advisors capacities to assess social and economic implications lessons learned are the basis for a systematic engagement of policy makers to create feasible and desirable pathways for the development of forest advisory systems in europe and to integrate forest advisors into the member states akis all these activities are supported by an analysis of the forest knowledge and innovation systems and the needs and preferences of its different actors project activities are supported with dedicated communication and dissemination activities and exploited through tailored impact pathways including a digital knowledge platform as the project advances a smooth transition towards a selfsustained network is embedded into project activities a dedicate task identifies working modalities and business models for the longterm continuation of the network building upon the experience of the forext initiative foradvise consortium gathers europes main actors in forestry advice
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shiftting the narrative of the climate generation ecology emotions and critical thinking in young adult contemporary climate fiction
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shiftgen investigates how narratives of climate change can affect young generations proposing the first extensive study of young adult climate fiction ya clifi in english 20002023 interest age 1319 years emerging studies reveal that the chronic fear of environmental catastrophe is particularly affecting young peoples daily life feelings of climate anxiety and ecogrief are amplified by a sense of intergenerational injustice with the socalled climate generation often portrayed as an innocent victim that adults are failing to protect by adopting an ecocritical perspective my research will examine whether ya clifi portrays young adults as assertive leaders and protagonists shaping their own future moreover combining recent developments in ecocriticism namely econarratology affective ecocriticism and empirical ecocriticism this project will investigate whether ya clifi is able to prompt the development of ecological citizenship communicate fears and hopes about the future and inspire creative thinking and longterm action given its scope and purpose the proposed research is a timely contribution to current ecological debates and can offer significant insights on the connection between the health of people animals and ecosystems engaging in a one health approach this threeyear action will be undertaken under the supervision of prof r baccolini unibo and prof e james uidaho and includes a secondment supervised by prof m caracciolo ugent it will comprise a transversal training and the acquisition of transferable skills as well as a targeted program of dissemination and communication activities the project will also undertake citizen science research engaging with university students of the emiliaromagna region to explore the impact of ya clifi on young readers climate change emotions thus employing the theoretical categories of the project to reflect on local communities and fragile landscapes
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the european living lab on designing sustainable urban mobility towards climate neutral cities
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elaborator uses a holistic approach for planning designing implementing and deploying specific innovations and interventions towards safe inclusive and sustainable urban mobility these interventions consist of smart enforcement tools space redesign and dynamic allocation shared services and integration of active and green modes of transportation they will be specifically codesigned and cocreated with identified vulnerable to exclusion user groups local authorities and relevant stakeholders the interventions will be demonstrated in 6 lighthouse and 6 follower cities across europe with three principal aims i to collect assess and analyse user needs and requirements towards a safe and inclusive mobility and climate neutral cities ii to collect and share rich information sets made of real data traces from dedicated toolkits users and stakeholders opinions among the cities so as to increase the take up of the innovations via a twinning approach and iii to generate detailed guidelines policies future roadmap and built capacity for service providers planning authorities and urban designers for the optimum integration of such inclusive and safe mobility interventions into sustainable urban mobility plans sumps the lighthouse cities are milan italy copenhagen denmark helsinki finland issylesmoulineaux france zaragoza spain and trikala greece the follower cities are lund sweden liberec czech republic velejne slovenia ioannina greece split croatia and krusevac serbia
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polymeric cyclodextrinbased supramolecular constructs photoreleasing nitric oxide for combating antibiotic resistance
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with more than 13 million people dying per year from infectious diseases multidrug resistance mdr in bacteria remains thegreatest challenge in public health care this scenario associated to the low turnover of new clinically approved antibioticdrugs makes the development of innovative therapeutic approaches to fight antibiotic resistance desperately needed toaddress this devastating societal problem in this frame supreme aims at the implementation of a novel strategy basedon unprecedented supramolecular platforms based on new cyclodextrin polymers integrating lightactivatable nitric oxide nophotodonors nopd alone and in combination with antibiotics currently employed in the clinic the final goal is to exploitthe double role of no generated with superb spatiotemporal control thanks to the light triggering as ibactericidal species not suffering mdr when produced at high doses micro molar ii inhibitor of the efflux pumps mainly responsiblefor mdr when produced at low doses to revert antibiotic resistance highly biocompatible branched polymers containing mixed alpha beta and gamma cyclodextrin units will be used as suitable hosts able to selfassemble into nanoparticles or gelsencapsulating the therapeutic cargo with high efficiency we will focus on nopds activatable exclusively with thebiocompatible visible light and on antibiotics representative of the classes of fluoroquinolones andtetracyclines known to display resistance and severe side effects full chemicophysical and photochemical characterizationof the systems is planned as well as assessment of their efficacy against planktonic microbial cells and biofilms the complementaryexpertise of the researcher and the supervisor supported by the private and academic teams hosting the fellow duringsecondments will create a multidisciplinary environment where all participants will benefit from reciprocal transfer ofknowledge
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structural basis of human u4atacu6atacu5 trisnrnp assembly
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minor spliceosome is responsible for the removal of a rare class of introns that are present in many essential genes despite its fundamental importance much information remains elusive for a comprehensive understanding of minor spliceosome assembly and the molecular basis of the diseases associated with its malfunctions in human in this proposal i will investigate the assembly process of u4atacu6atacu5 trisnrnp minor trisnrnp by isolating relevant complexes from human cells and determining their structures using cryoelectron microscopy cryoem the u4atacu6atacu5 trisnrnp is the largest preassembled building block of the minor spliceosome by applying cryoem and proteomics we will reveal the spatial organization and composition of the minor trisnrnp while the structures of its assembly intermediates will shed light on the role of assembly chaperones in the trisnrnp maturation consequently these findings will provide clues as to how minor spliceosome assembles to achieve its complex functionrecent advances in the field of cryoem have opened up the possibility to study large and dynamic spliceosomal complexes at a molecular level with our labs expertise in premrna splicing cryoem and mammalian cell culture we are perfectly positioned to exploit these new technologies to gain mechanistic insights into the assembly of the minor spliceosome
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a touch of blue in the eu research nights for a more sustainable use of the ocean
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the main objective of the proposal is to bring the many facets and faces of people working in ocean science research to the general public of europe by organising a series of interconnected eu blue researchers nights bluenights to demonstrate that the ocean can be a source of inspiration an object of intereststudy and a field of investigation for people with very different backgrounds hobbies and passions including science history technology sociology pedagogy economics art design etc by doing so this collective project will bring people to key objectives principles and priorities of the european green deal that relate to the ocean delivering a healthy and resilient ocean that can support sustainable blue growth and respond to societal priorities of europe contribute to make european citizens ocean literate in line with the objectives and priorities of eu4ocean coalition an initiative supported by the european commissions directorategeneral for maritime affairs and fisheries dg mare the project will build on the following principles collective and truly european mobilising organisations from each eu rsas to prepare activities and events for presenting their own researchscientific activities interdisciplinarymultidisciplinarytransdisciplinary the partner organisations from different eu ms will represent a diversity of disciplinary fields and research skillsexperiences that are focusing on the ocean and on the complex connections between human activities and ocean ecosystems immersive inclusive and interconnected by combining a an interactive and practical experiences on the spot in each of the partners location building on doing touching gaming trying exploring b an interactive virtual experience by way of an innovative virtual reality technology that will allow the public to explore both the ocean and researchers activities by simulating real life working conditons
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ambrosiotortorelli approach to topological singularities
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the exploration of topological singularities is a fascinating task of absolute relevance both from the theoretical and applied point of view for example in physics and materials science they arise from the study of mathematical models for vortices in superconductors grain boundaries in polycrystals fractures in solids and defects in crystals such as disclinations or dislocations furthermore topological singularities play an important role in the study of more geometric problems such as the plateau problem and the theory of minimal surfaces the goal of topsing is to study some physicalmechanical problems where singularities appear through a theoretical approach that opens promising directions also for other apparently unrelated situations like the nonparametric plateau problem in higher codimension more specifically we draw our attention to codimensiontwo singularities and consider twodimensional models for fields having point singularities which are relevant in the study of two main problems 1 screw dislocations in crystals and their relation with vortices in superconductors 2 the nonparametric plateau problem in codimensiontwothe main novelty consists in developing a unified approach inspired by the classical model by ambrosio and tortorelli at that allows to study topological singularities in both contexts listed above furthermore this will provide a model which is easier to handle numerically and thus interesting from the point of view of applicationsthe project is organised into four main objectives whose common thread is the asymptotic analysis of elliptic functionals la at for maps taking values on the unit circle to our best knowledge there are no similar results in the literature this is due to the non trivial task of constructing a recovery sequence that takes values on the circle which we aim at achieving by relying on degree theory and by using techniques developed to study the relaxed area
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peptinsure using peptides to ensure assure and insure protein authenticity and quality
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food fraud and mislabeling undermine public trust in the food industry and regulatory bodies the scale of these issues is heightened by the socalled protein gap peptinsure offers a new solution to authentication of protein in the food and feed industries by leveraging the strengths of zooms for peptide mass fingerprinting pmf and the novel lapmaldi technology enhancing the specificity affordability and efficacy of protein analysis this unique combination alongside advanced software tools enables peptinsure to transcend the limitations of existing methods such as specificity issues costliness and the impact of processing on detectability positioning it as a pioneering solution capable of redefining protein analysis standards these factors combine to position peptinsure as a pioneering approach that could redefine standards for protein analysis in food and feed with implications for safety quality and consumer trust while existing methods each contribute valuable tools for protein analysis in food and feed they are often hampered by limitations related to specificity cost and the impact of processing on detectability peptinsures innovative integration of technologies aims to overcome these challenges offering a comprehensive reliable and costeffective solution for protein authentication and quality assurance in the food industry if successful peptinsure stands to offer groundbreaking innovations in the field of protein analysis with farreaching implications for food safety quality assurance and market integrityhowever the projects highrisk elements including the integration of complex technologies adaptation to diverse matrices and the need for advanced data analysis approaches pose significant challenges overcoming these challenges will require innovative solutions interdisciplinary collaboration and a commitment to research and development underscoring the highriskhighgain nature of the peptinsure project
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physical degradation modelbased feedback control design for efficient ev battery bms integration
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phybatt covers the development of algorithms and models to be embedded in the bms to allow the battery to operate within the safety boundaries at any time and in each battery operating mode the models to be developed and embedded in bms algorithms can be applied in realtime battery control for various applications such as fast charging peak shaving in the grid and ancillary services with energy storage leading to an improved technoeconomical offering this adds a vehicle to grid v2g mode corresponding to many support situations
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spreading the global potential of developing innovation ecosystems to strengthen innovation in regional and local businesses
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spread2inno brings together different innovation stakeholders incubators accelerators innovation businesses research organizations consultancies and networks from crucial european innovation regions germany belgium austria bulgaria greece and italy the goal is implementing scalable replicable and holistic 2 year program for the provision of high quality business services and collaboration between different entities of wellconnected and less connected regional innovation ecosystems with immediate impacts on the local and eu level in order to create a sustainable and replicable model easily adopted by the rest of eu the consortium will implement a set of activities for enhancing capacity and competitiveness of both business acceleration entities and smes and startups particularly 6 local events that will provide insight of networking and exploring opportunities across europe that relate to scalingup of businesses along with training courses aimed at improving business and marketing case of businesses including roundtables for acceleration entities for educational and practical exchange and crosscontamination an online platform as a single point of reference for information exchange between different innovation ecosystems about opportunities events and funding accessible in these regions 2 intensive educationaltraining academies as well as tailormade feasibility studies for participants a oneweek business case and investor training for finalists at least 50 womanled businesses delivered through collaboration of developed and less developed innovation ecosystem entitiesthe spread2inno unique and interdisciplinary methodology will enhance business activities in less developed innovation regions reinforce their acceleration capacity and enable entrepreneurs to scale their concept to a fully concrete solution with strong market potential subsequently enhancing the development and competitiveness of these regions
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new crisis and old mysteries resolving cosmic tensions to reveal the dark sector
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it has recently been established that the current expansion rate of the universe ie the hubble constant as measured by local probes is discrepant at 5 with that predicted in the standard cold dark matter cdm model calibrated onto cosmic microwave background cmb data additionally analyses of the latest galaxy weak lensing surveys find an amplitude of density fluctuations on large scales the s8 parameter that is about 23 lower than what is predicted in cdm this growing crisis is potentially the first indication of a departure from the cdm model giving hopes to access the fundamental properties of the mysterious dark matter and dark energy that pervade the universe on the one hand i have shown with my colleagues that the hubble tension could indicate the presence of new physics in the era prerecombination potentially connected to new dark energy properties at early time on the other hand the s8 tension can be connected to new dark matter properties and in particular could indicate that dark matter is not stable on cosmological timescales or interacts with some new light species yet none of the suggested models have been robustly detected nor are they able to explain simultaneously the hubble and s8 tensions with the support of the erc i will build a group that will develop public tools to firmly identify the new physics mechanism required to explain these cosmic tensions assess the observational consequences for a wide variety of observables and the implications for the nature of dark matter and dark energy
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kelp side stream valorisation to develop new biobased value chains
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brown algae particularly l hyperborea represent a largely untapped renewable resource in europe present in huge volumes along the coastlines of norway approximately 60 of global biomass sweden denmark ireland iceland and france l hyperborea contains alginate cellulose functional polysaccharides like fucoidan and laminarin phlorotannins polyphenols as well as protein vitamins and minerals all ingredients in demand in europes biobased value chains however current harvesting techniques particularly widespread use of formaldehyde is limiting the huge valorisation potential of this promising renewable feedstockonce brown kelp is exposed to air chemical and enzymatic reactions quickly begin to rot the harvest currently harvesters mitigate this by treating brown kelp with formaldehyde during and after harvesting however formaldehyde causes undesirable browning of some compounds and is toxic so must be removed through expensive energy and water intensive washing prior to further processing this makes valorisation of all but the most valuable alginate fraction 15 of l hyperborea biomass uneconomic consequently about 85 of the residual brown kelp biomass is flushed back into the sea unused proteus addresses the challenge of maximising valorisation of europes l hyperborea biomass through the optimisation of alginors coordinator and hypomars formaldehydefree harvesting and extraction technologies and approaches this will enable largescale valorisation of europes considerable l hyperborea resource and conversion of 100 of the biomass into ingredients that will be tested in validated for use by essity personalcare olmix feed vaess food and borregaard industrial applications as dropin replacements for synthetic materials in sustainable biobased product lines
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scalable quantum computing with continuous variable cluster states
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measurementbased quantum computation is a highly promising approach to quantum computing as it simply performs quantum processing directly through the measurements of a multipartite entangled cluster state and thereby circumvents the complex unitary dynamics of conventional gatebased quantum computers however despite significant progress over the last decade in devising new strategies for measurementbased quantum computing significant conceptual and technical challenges still remain for realizing upscaled versions that reach the quantum advantage regime where it outperforms classical computation in clusterq we aim to overcome these challenges using continuous variable threedimensional entangled cluster states based on our recent work on generating and exploiting extremely large twodimensional clusters states we aim to make conceptual breakthroughs along three different directions first we deterministically generate highly scalable threedimensional cluster states of different topological structures and explore their manybody behaviour and usefulness for quantum computing next we use the threedimensional cluster states combined with hybrid detection technologies to demonstrate new quantum boson sampling algorithms a nearterm quantum computing algorithm allowing for a demonstration of quantum computational supremacy and finally we explore theoretically and experimentally a novel strategy for faulttolerant measurementbased quantum computation using surfacecodes in 3d cluster states clusterq aims to position the continuous variable measurementbased approach to quantum information processing in the field of frontrunning candidates for nisq noisy intermediatescale quantum computing and in the longer term faulttolerant quantum computing
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hpc alliance for applications and supercomputing innovation the europe japan collaboration
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a number of european leading research organizations referred as rtos hereafter and research supporting organizations with a long history of scientific and technology collaboration with japan are building a consortium for a proposal focusing on the development of joint high performance computing hpc applications for future generations of supercomputing platformsarchitectures preexascale exascale postexascale from europe and japan european and japanese research centers work together to develop and optimize applications of these methods in various scientific fields such as material biomedical and health especially covid19 research drug design and environmental sciences such as climate modeling seismology and prevention of natural disasters and many other fields such as high energy physics astrophysics quantum computing etc the existing joint activities between the european consortium and the japanese research institutes will bring together the required expertise to develop applications this expertise ranges fromfundamental research and applied science for designing new models to the optimization development and the integration of new and ambitious workflows and models to efficiently profit from preexascale exascale postexascale and hybrid architectures deployed or already operational in europe and japanthe european consortium gathered in the hanami proposal is willing to support and foster joint scientific teams to improve the performance and transferability of european and japanese hpc applications by leveraging the skills and expertise of the scientific community within europe and japan this consortium focuses on the hpc ai and da application communities represented by the coes academic and industrial organizations addressing the strategic research areas that are material biomedical and climate
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erachair in tree bioengineering
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advancing biotechnological innovation in the forest biorefining sector is crucial for europe to meet climate objectives and driving the shift towards a carbonneutral economy however challenges such as preserving natural forest ecosystems and promoting sustainable development practices offer opportunities for growth recent geopolitical events like the russian invasion of ukraine highlight the need to explore alternative supply chains and build industry resilience the decline of the fossilbased industrial region in northeast estonia acts as a catalyst for transitioning towards forest biorefinery solutions prompting proactive measures to address environmental concerns and historical pollution from past mining activitiestreebiotec will innovate alternatives led by prof jaakko kangasjrvi an era chair holder by establishing a research group for tree bioengineering at the institute of bioengineering ut this initiative aims to enhance photosynthesis growth rates and resilience of birch trees fostering reforestation carbon capture and soil bioremediation of contaminated mining areas for the wood industryfurthermore treebiotec strives to capitalize on public interest in bioengineering through a public awareness campaign engaging stakeholders and fostering dialogue on biotechnological advancements leveraging geographic proximity and industry connections between estonia and finland the project cultivates a collaborative ecosystem accelerating bioengineering effortsadditionally the initiative fosters creativity by drawing inspiration from programs like gingko bioworks creative residency collaboration among scientists architects landscaping artists and experts will create an innovative living laboratory exploring bioeconomy solutionsthrough treebiotec the institute of bioengineering positions estonia as a leader in forest biotechnology catalyzing advancements and fostering collaboration to address global challenges
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poparch the role of population scale genetic variation in chromosome 3d architecture
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the linear onedimensional 1d dna fiber inside each eukaryotic cell nucleus folds into a precise threedimensional 3d structure whose structural preservation is vital for correct cell homeostasis and generegulatory mechanisms previous studies showed that if 3d structure is altered aberrant phenotypes and diseases can arise however little is known on how 1d variation can affect 3d genome variation although recently developed technologies allow researchers to generate data to characterize the 3d structural patterns as of yet no studies have systematically examined how this affects interindividual 3d variation i hypothesize a substantial fraction of 3d genome structural variation is controlled through 1d variation affecting gene expression and lastly phenotypes i will test this by quantifying 1d and 3d genomic variation from 100 individuals selected from a chicken cohort my host raised under extremely wellcontrolled environmental conditions making it the largest study of its kind up to today and the first to use an in vivo animal model then computationally i will develop an analytical framework and produce a catalog of dna sequence variants that condition 3d genome structure upon executing my research i expect to provide a new explanation on how noncoding dna variants can exert their effect thus offer new testable hypotheses to researchers interested in genotypephenotype transitions this is a proofofconcept project and should i be correct will open a door to expansion in other species including humans with a large potential use in medical genomics thus facilitating pharmacological interventions by disentangling causal intermediate processes by combining my 3d genomics expertise with the hosts populationstatistical genomics knowledge on his unparalleled cohort of chickens i will develop unique expertise to place me as the pioneer of a completely new multidisciplinary field
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signit signacula in roman and postroman italy marking religious and cultural identity 2nd11th c ce
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the signit signacula in roman and postroman italy marking religious and cultural identity 2nd11th c ce project aims at studying the cultural history of the italian peninsula from the roman imperial period to the central middle ages by means of the objects known as signacula ie matrices bearing text signs andor iconographic motives designed to stamp various materials linguistic choice is one of the main markers of identity thus the project focuses on materials found or originally coming from a sample of italian regions featuring both latin and greek speaking communities veneto emiliaromagna campania apulia calabria sicily and sardinia the historical value of this body of evidence has been hitherto largely neglected due to its difficult dating to overcome this issue i will study for the first time the corpus as a whole from antiquity to the middle ages the projects objectives are threefold firstly to establish a clear dating protocol for the signacula to unlock their full potential as historical sources secondly building on the newlydated material to study the evolving linguistic patterns and their contribution to the making of specific local identities between antiquity and the middle ages thirdly to track over the longue dure changes in marking practices and to analyse them as proxies for cultural transformations to achieve these goals i will build up an openaccess database gathering published and unpublished signacula pertaining to the chronological and geographical framework under scrutiny the databases structure will allow both qualitative and quantitative analysis of the material and will facilitate comparisons with other types of stamped writing and of inscribed objects eg seals by adopting and building upon the technical features and norms of the text encoding initiative standard tei httpsteicorg developed for the digital edition of ancient inscriptions epidoc and seals sigidoc
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norwegian romantic nationalisms
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norn seeks to uncover both the affective and ideological dynamics of romantic nationalism examining how collective emotions related to the idea of the nation were harnessed activated and constructed through literature and theater using norway as a case study norn forges a highly innovative approach combining cultural studies affect theory critical race studies and reception studies with qualitative methods taken from literary studies and history as well as quantitative methods from the digital humanities in order to achieve three interconnected objectives 1 a comprehensive modeling of nineteenthcentury norwegian literature using machine learning 2 a metacritical reassessment of literary historiography as an explicitly romantic nationalist project and 3 a radical reevaluation of the impact of transnational romantic performance culture on nationbuilding norn approaches romantic nationalism from two distinctive perspectives on the one hand the project seeks to understand the affective register of romantic nationalism qualitatively which entails meticulous investigation of a wide range of sources through an innovative combination of theoretical lenses in order to recontextualize it as what raymond williams famously called a structure of feeling on the other hand norn profoundly decontextualizes the literary works themselves through socalled distant reading methods carrying out an ambitious computational modeling of the entire nineteenthcentury literary field this will enable an interrogation of prevailing master narratives about periodization and processes of inclusionexclusion delineating romantic nationalism based on far more transparent criteria than those that underpin traditional literary historiographical methods
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enhancing safety of liquid and vaporised hydrogen transfer technologies in public areas for mobile applications
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international standards related to cryogenic hydrogen transferring technologies for mobile applications filling of truck ship stationary tanks are missing and the experience is limited or nonexistent elvhys aims to provide indications on inherently safer and efficient cryogenic hydrogen technologies and protocols in mobile applications by proposing innovative safety strategies including selection of effective safety barriers and hazard zoning strategies which are the results of a detailed risk analysis this is carried out by applying an interdisciplinary approach and conducting experimental theoretical and numerical studies both on the cryogenic hydrogen transferring procedures and on the phenomena that may arise from the loss of containment of a piece of equipment containing hydrogen unique investigations on i cryogenic hydrogen transferring operations for selected mobile applications ii equipment and materials response to liquid hydrogen lh2 transfer and incident roots as well as iii releases combustion and explosion phenomena will be pursued for the first time a study on the frequency of failure of lh2 transferring equipment will be carried out by exploiting the internal databases of some of the consortium partners which contain valuable information collected in the last decades in addition critical and exclusive data on innovative safety barriers eg emergency release device under development will be shared by air liquide partner beyond knowledge on cryogenic hydrogen transfer gained in several years in this fashion critical inputs can be provided for the development of international standards by creating safe and optimised procedures and guidelines for cryogenic hydrogen transferring technologies the results of elvhys will contribute to many objectives of the clean hydrogen ju sria such as increase the level of safety and support the development of regulations codes and standards for hydrogen technologies and applications
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targeting telomeric dna damage response as a new strategy to fight immunosenescence and improve vaccine response
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the immune system is remodeled with age going through a series of changes known as immunosenescence including the involution of primary lymphoid organs the contraction of the immune repertoire a progressive lineage skewing towards the myeloid lineage and a lowgrade proinflammatory status a consequence of immunosenescence impacting the morbidity and mortality of infectious diseases is a dramatically reduced vaccine response in the elderly thus reducing the burden of immunosenescence has the potential to impact the effectiveness of vaccine response an established hallmark and driver of ageassociated functional decline is telomere dysfunction dysfunctional telomeres are actively transcribed to generate telomeric noncoding rnas tncrna which are essential to recruit dna damage response ddr factors at damaged telomeres thus fueling ddr and causing cellular senescence initiation and maintenance sequencespecific telomeric antisense oligonucleotides tasos target these tncrnas and effectively inhibit ddr activation ameliorating agerelated phenotypes in mouse models the telomerasedeficient terc mouse model causes telomere shortening and dysfunction recapitulating features of immunosenescence immune system reactivity reduction decreased long term renewal of hematopoietic stem cells and lymphocytes numbers increased neutrophil count tasos treatment has beneficial longterm effect in this model by decreasing immunosenescence and counteracting inflammation we now plan to test the efficacy of tasos treatment on rejuvenating the immune system of aged wild type mice a physiological setting for aging the final goal will be to assess if tasos impact on vaccine response in both models young terc mice and aged wt mice in summary we plan to determine the efficacy of tasos to improve immune responses including vaccines in the elderly
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nimble artificial intelligence driven robotic solutions for efficient and selfdetermined handling and assembly operations
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over the last years production has been shifted from mass production to customization the conventional production lines traditionally focused on one product variant or one family of products do show their limitations to cope with the new needs moreover unprecedented worldwide events such as the recent pandemic crisis indicated even more the need for flexible production systems that can rapidly switch production to a totally different one eg automotive manufactures had to produce respirators facemasks etcas a response masterly aims to develop flexible robotic solutions constituting of modular grippers combined with stateoftheart robotic technologies such as mobile high and low payload industrial and collaborative robots and smart cranes enhanced with ai driven advanced control and perception capabilities that will allow them to act autonomously handling a large variety of parts varying in size shape and material while being acceptable by both genders of workforce the developments will focus around the following 5 pillars1 innovative efficient and low consumption systems for storage retrieval conveying and pickandplace using a multidisciplinary approach combining technologies 2 robust handling devices and systems with integrated ai driven advanced control3 userfriendly interfaces for robotmachine control and programming4 interoperable sw and hw interfaces 5 industrial pilot cases for work piece handling in full production linethe technologies will be tested for flexibility efficiency user acceptance in three use cases from different productions sectors aiming to demonstrate production line and cross sector applicability and adaptability elevators manufacturing focusing on the assembly of electrical cabinets of lifts kleemann sportswear focusing on warehouse logistics and packaging decathlon and aeronautics production focusing on production of large composite panels of aircraft wings aernnova
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transdisciplinary and deliberative equity appraisal of transition policies in energy and mobility
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numerous attempts of implementing transition pathways across europe illustrate the difficulty of designing policies that combine efficient climate action and justice considerations one reason is that the socially diverse and thus also geographically dispersed demands and vulnerabilities of potentially affected groups do not appear as a wellstructured input at any stage of the policymaking process therefore tandem will test an innovative transdisciplinary approach in five different case studies in spain belgium finland poland and austria that address controversial transition policies in energy and mobility affecting urban and rural populations the tandem project aims to design a methodology allowing policy makers to create and implement inclusive and just transition pathways by involving potentially affected citizens public authorities the private sector and other relevant stakeholders it relies on combination of accessible and complementary methods deliberative visioning build on artbased approaches system mapping assessment and appraisal methods these methods constitute the backbone of a series of three deliberation panels with citizens in these panels tandem invites participants to create their visions perspectives and narratives on just transition policies and to define their own criteria and interventions this deliberation process will guide a systemic impact assessment that will inform individual appraisals of the interventions public authorities will be involved at the beginning and end of each panel to provide insights on political social and economic factors that should be taken into consideration furthermore private companies will be invited to participate through interviews and surveys tandem will thus develop a transdisciplinary approach to identify and analyse emerging inequalities of lowcarbon transition policies as well as to codesign socially fair and effective alternative transition pathways with stakeholders
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modelling text as a living object in crossdocument context
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interpreting text in the context of other texts is very hard it requires understanding the finegrained semantic relationships between documents called intertextual relationships this is critical in many areas of human activity including research business journalism and others however finding and interpreting intertextual relationships and tracing information throughout heterogeneous sources remains a tedious manual task natural language processing nlp fails to adequately support it mainstream nlp considers texts as static isolated entities and existing approaches to crossdocument understanding focus on narrow use cases and lack a common theoretical foundation data is scarce and difficult to create and the field lacks a principled framework for modelling intertextualityintertext breaks new ground by proposing the first general framework for studying intertextuality in nlp we instantiate our framework in three intertextuality types inline commentary implicit linking and semantic versioning we produce new datasets and generalizable models for each of them rather than treating text as a sequence of words we introduce a new data model that naturally reflects document structure and crossdocument relationships we use this data model to create novel intertextualityaware neural representations of text while prior work ignores similarities between different types of intertextuality we target their synergies thus we offer solutions that scale to a wide range of tasks and across domains to enable modular and efficient transfer learning we propose new documentlevel adapterbased architectures we investigate integrative properties of our framework in two case studies academic peer review and conspiracy theory debunking intertext creates a solid research platform for intertextualityaware nlp crucial for managing the dynamic interconnected digital discourse of today
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characterization of multispecies bacterial interactions underlying the beneficial symbiosis of a mediterranean squid
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animals often use associations with microbes to preserve their health these mutualisms are maintained by hostmicrobe communication and though interactions between bacterial symbionts the squidvibrio symbiosis has been used for over 30 years to study beneficial hostmicrobe associations however nearly all studies of the symbiosis have used euprymna scolopes and its only symbiont vibrio fischeri which precludes examination of how multiple microbial species affect symbiosis using the squid sepiola affinis and its two symbionts v fischeri and vibrio logei the squidvibrio project proposes to examine the effects of multiple microbial species within a mutualism the project is organized into three objectives 1 implement a husbandry facility for s affinis 2 quantify the symbiont populations within the s affinis light organ over seasons and over maturation 3 identify how the symbiont populations alter metabolites within the light organ first a husbandry facility will be established at the banyulssurmer oceanographic observatory that will allow for the maintenance of wild s affinis and for rearing of the squid second metagenomics will be used to estimate the proportions of v fischeri and v logei within the light organ subsequently light organs of fieldcaught and reared squid will be imaged using confocal microscopy to identify if the vibrio spp inhabit mixed or distinct niches the third objective will use lcms and mass spectrometry imaging to identify metabolites that are altered by each vibrio spp and how localization patterns of these molecules are affected these methods will allow for the twoway transfer of knowledge with the researcher providing squid husbandry techniques and the host institution providing genomics and metabolomics the squidvibrio project will establish s affinis as a model organism in europe that can provide insights into how symbionts interact both with each other and their host to underly a mutualism
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from big data to new science and practical solutions
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from big data to new science and practical solutions data4healthcare is a novel postdoctoral programme hosted at an international and multidisciplinary research environment of university of oulu uoulu finlandthe data4healthcare addresses the great demand for specialists in all fields who are capable of working with different types of massive datasets understand different datasources and legislation related to the demand of turning them into useful information for decision making in healthcare this is achieved by tackling some of the most important scientific problems by collaborating intensely with experts from different disciplines and stakeholders and educating wellqualified postdoctoral researchers to meet the requirements of the 21st century data4healthcare trains 25 postdoctoral researchers to better exploit and develop the possibilities of big data in the eu and globally the aim of the data4healthcare programme is to offer cuttingedge research research training and career development for experienced researchers of any nationality in fields associated with big data data analytics machine vision and artificial intelligence the oulu ecosystem with worlds smartest hospital strong background in ehealth and ict for example 6gflagship as worlds first 6g research programme to develop the future of wireless communication technologies research teams utilizing large molecular data expertise in artificial intelligence and several companies locally and in collaboration offers unprecedented surroundings for the programme the identified primaryfocus themes of research in the programme in uoulu are data as new resources in the society health data management practices in rdi collaboration technical tools in data management and processing
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recovering plasmafacing components temperatures in fusion devices from ir camera measurements
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infrared ir cameras are key diagnostics to monitor and control plasmafacing components pfcs in fusion devices nevertheless the use of allmetallic pfcs with low and variable emissivity 0105 makes it difficult to obtain a correct surface temperature measurement the radiance collected by the ir camera includes both the thermal radiation emitted by the target and parasitic radiation coming from the targets surroundings furthermore target emissivity changes with the surface temperature and roughness this causes significant errors in the surface temperature measurement that we need to address for achieving high power and safe plasma operation inaccurate interpretation of ir temperature measurement could endanger machine safety temperature underestimation or on the contrary lead to unnecessary pulse interruptions that reduce the overall performance of the machine temperature overestimation the current approach is to convert the radiance collected by each pixel in an apparent using a physical relationship between emitted radiance and temperature plancks law because a portion of the collected radiance is due to reflection on the target a systematic error is made this method is unable to recover the portion of reflected radiance and to deduce the correct temperature of the target using only the emitted radiance the proposed technique in this project is to use a digital twin of the machine and to make in it assumptions on the temperatures of the different elements of the machine in order to simulate the images that would be measured under these supposed conditions by comparing to the real image measured by the camera and using optimization techniques the assumptions on the parameters can be updated until the simulated and measured images are close enough it is then deduced that the assumptions made on the parameters of the digital twin are correct and that they correspond to the real temperatures in the machine
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addressing sustainability transition pathways in the blue economy
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oceans are a lifesupport system for human societies they supply fundamental goods such as fish food materials energy and provide benefits associated with our wellbeing they form cultural values and contribute to jobs creation and trade the development of national ocean development plans combined with blue growth bg strategies are turning the ocean into a new frontier of industrial development in fact the eus blue economy produces a turnover of 750 billion euroyear however the actual sustainability of this blue acceleration process remain to a large extent uncertain due to 1 an unclear interpretation of the concept of blue growth across different policies the 2 multiple human pressures across scales and marine regions cause ecological degradation with high social costs and 3 the lack of integrated methodologies that can capture the effects of the bg trends on oceans health and human wellbeing over spatiotemporal scales there is an urgent need for interdisciplinary approaches that can address the pathways of sustainable transitions in marine realms and the deriving benefits and costs to society and the environment bluepaths aims to 1 develop an integrated humanocean framework for bg
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european integration of new technologies and socialeconomic solutions for increasing consumer trust and engagement in seafood products
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fisheutrust represents a consortium of twentytwo organizations from fourteen countries pooling their expertise to defragment the current food system to ensure sustainability and deliver solutions for a transparent and traceable seafood supply chain necessary to promote highend paneuropean farmed seafood the innovation at the heart of fisheutrust is integrating different actors into a digital platform that links technology providers supply chain stakeholders regulatorypolicymakers and consumers fisheutrust will establish five cocreation living labs clls in diverse environments the mediterranean basin the north sea and the atlantic sea these clls will enable user involvement in innovation and development processes and act as demonstrators for the consortium to test and validate digital and nondigital supply chain solutions examples include creating sustainable business models exploiting ipr strategies for aquaculture eg protecting cultural and culinary heritage short food supply chains exploiting underused fish species and innovative engaging activities to stimulatenudge behavioural change it will also develop tools for maximizing trust by guaranteeing the quality safety and traceability of seafood products based on smart control systems sensors a suite of tools integrating metagenomics genetic biomarkers isotopic techniques and digital technologies labelling product passportblockchain these tools will be integrated into a single cuttingedge digital fisheutrust platform that will apply the latest in artificial intelligence data science and humancomputer interactions finally an integrated impact assessment and life cycle analysis will be performed to quantify the environmental footprint health sustainability and socioeconomic benefits of fisheutrust solutions fisheutrust will be supported by a comprehensive scientific public policymaker and industrial dissemination plan to communicate results to a broad audience
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stability and transition in extracorporeal blood flow devices understanding flowinduced hemolysis and thrombogenesis
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the blood flow in extracorporeal medical devices is exposed to nonphysiological conditions which may lead to red blood cell damage and clot formation several therapies are applied to patients to prevent these phenomena but they all come with side effects understanding the causes of flowinduced hemolysis and thrombogenesis would reduce the need for medical therapies thus enhancing the wellbeing of the patients an extracorporeal membrane oxygenation ecmo circuit is made up of several components a blood pump a membrane oxygenator cannulae tubes and connectors the blood flow through these components is either turbulent or transitional thus the blood is subject to hydrodynamic stresses that may lead to hemolysis or platelet activation the link of these two undesired phenomena with the flow regimes and the transition mechanism has not been investigated in previous studies and it is the aim of the current project we will perform highfidelity threedimensional numerical simulations of the flow in the connectors and the curved flexible tubes of an ecmo circuit a nonnewtonian rheological model will be assumed for the blood viscosity transition to turbulence will be studied employing both modal and nonmodal threedimensional global stability analysis for this purpose a timestepping technique will be implemented in the numerical code developed by the hosts group combined with a method for solving largescale eigenvalue problems finally an adjoint sensitivity analysis of the hemolysis index and the platelet activation state to boundary conditions and modifications in the flow will be performed these results will provide insightful information for the design of medical devices with increased hemodynamic performance
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promoting fairness of the music ecosystem in a platformdominated and postpandemic europe
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the overarching goal of fair muse is to promote fairness for music creators and stakeholders from an interdisciplinary perspective thus leading to a more transparent competitive and sustainable music ecosystem in europe fair muse focuses specifically on the domination of online platforms and their algorithms and will investigate i the legal responses that have been proposed in the eu ii the changes these platforms have brought to the music industry and music professionals and iii the impact of such algorithms on music consumption fair muse will provide an interdisciplinary analysis of fairness in the music industry involving music creators and stakeholders in the research promote and enhance transparency concerning music industry practices and standardisation in data collection in the european music ecosystem and assess the risks created by the reinforced dominance of the largest online platforms prompted by covid 19 as well as making policymakers stakeholders and the general public aware of such risks to do so fair muse will provide an innovative strong and futureproof set of cocreated responses and solutions the music copyright infrastructure a datasharing model agreement enhancing transparency a music data dashboard of statistical indicators on the economic and societal value of the european music sector the fairness score a tool to assess music services and social media in terms of fairness multiple facets and a white paper embodying policy recommendations to enhance competitiveness sustainability transparency and fairness of the eu music ecosystem our consortium is a carefully designed interdisciplinary group of academic and industry partners with strong expertise in the fields of law economics political science and computer science supported by an advisory board composed of a highly qualified and broadly representative group of industry experts
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zeroloss energy harvesting using nanowire solar cells in space
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the zeus project is focused on advancing the development of innovative highly efficient and radiationresistant nanowire solar cells designed for inorbit solar energy collection while current spacetested nanowire solar cells offer around 15 efficiency using singleband gap cells zeus aims to significantly enhance this efficiency potentially reaching up to 47 by employing triple junction nanowire cells with a carefully selected set of iiiv semiconductor materials to this end this interdisciplinary project will also optimize nanowire surface passivation schemes to improve voltage and current matching of the solar cell this project aims to achieve scalability through a peeloff technology that transfers solar cells onto lightweight flexible substrates creating a thin film enabling the creation of large deployable photovoltaic panelskey objectives include1 enhancing the efficiency of radiationresistant nanowire solar cells2 scale up wafer size to 100mm2 and develop modules at a size of 1x1 cm23 improving power conversion efficiency in breakthrough wireless power transmission systems based on iiiv nanowire mosfets4 reducing weight and material usage through nanowire peeling and wafer reuseadditionally the project underscores its commitment to environmental sustainability by focusing on two key aspects decarbonization and the efficient use of critical raw materials by means of a life cycle assessment of nanowire solar cells zeus seeks to demonstrate the environmental benefits and commercial potential particularly for space energy generationthis research has farreaching applications including integrating nanowirebased devices into stretchable polymer films offering flexibility in solar cells electronics detectors and leds selfpowered nodes for iot or cryogenic electronicsan industrial advisor from azur space solar will help the project with scalability and exploitation strategy
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connected headset adapting music to emotions
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this project aims to contribute to individual wellbeing by offering a device that adapts music to the users emotions ontbo is a software coupled with neurotechnology that detects interprets and adapts audio content to human emotions in real time ontbo measures the emotional state in real time concentration stress relaxation thanks to a connected headset with an electroencephalogram the various ais will then deliver the appropriate playlists to enable the user to reach the desired emotional state
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a neuroscientific foundation of program comprehension
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the pivotal role of software in our modern world mandates strong requirements on quality correctness and reliability of software systems in software development and maintenance the ability to understand program artifacts plays a key role for programmers to fulfill these requirements despite significant progress research on program comprehension has a fundamental limitation program comprehension is a cognitive process that cannot be directly observed which leaves considerable room for misinterpretation uncertainty and confounders in brains on code we will develop a neuroscientific foundation of program comprehension instead of merely observing whether there is a difference regarding program comprehension eg between two programming methods we aim at precisely and reliably determining the key factors that cause the difference this is especially challenging as humans are the subjects of study and interpersonal variance and other confounding factors obfuscate the results the key idea of brains on code is to leverage established methods from cognitive neuroscience to obtain insights into the underlying processes and influential factors of program comprehension brains on code will pursue a multimodal approach that integrates different neurophysiological measures as well as a cognitive computational modeling approach to establish the theoretical foundation this way brains on code will lay the foundations of measuring and modeling program comprehension and offer substantial feedback for programming methodology language design and education addressing longstanding foundational questions such as how can we reliably measure program comprehension what makes a program hard to understand and what skills should programmers have will become into reach a success of brains on code would not only help answer these questions but also provide an outline for applying the methodology beyond program code models specifications etc
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vital intelligence to investigate illegal disinformation
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identifying tracking and investigating online disinformation and other problematic content is an extremely complex problem many european police authorities pas do not have access to any specialised tools or technologies to help them combat disinformation some of the better equipped pas are using unsuitable offtheshelf products that were designed to enable commercial companies to monitor social media chatter about their brands and products or to track the success of advertising campaigns such products are not capable of dealing with the complexities of disinformation nor do they provide advanced analysis tools and technologies tailored to the pas needs the vigilant project solves this problem it is an integrated platform of advanced disinformation identification and analysis tools and technologies employing stateoftheart ai methods which were developed as part of several highly successful fp7 and h2020 projects they will be tailored to pas use cases and needs following an ethicalbydesign and usercentric approach in addition social and behavioural aspects are also taken into account when designing tools and presenting results vigilant covers disinformation from all major sources eg major social media platforms fake news websites in all modalities text image video and in multiple languages it is also suitable for investigating hate speech violent nationalist or separatist movements radicalisation extremist groups incels loan wolfs and other counter terrorism threats the project also provides innovative solutions to leverage the knowledge and experience of other stakeholder organisations and social media companies finally the project includes training for pas in the use of vigilant and in conducting disinformation investigations as part of a long term sustainable training network the interdisciplinary consortium includes expertise from social sciences and humanities ethics computer science commercial and four european pas
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development of innovative membrane and cold atmospheric plasma reactor for the degradation of per and polyfluoroalkyl substances pfas
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the high chemical stability of per and polyfluoroalkyl substances pfass made them widely used in industrial and commercial applications such as surfactants and emulsifiers causing pfass to enter many water sources around the world the toxic and carcinogenic pfass that have entered our water cycle are one of the greatest concerns in the 21st century removal of pfas by conventional methods results in secondary pollution so it is essential to degrade pfas using advanced oxidation processes according to recent studies the cold atmospheric plasma cap treatment provides a superior purification in pfas degradation compared to other advanced oxidation processes however the mineralization of shortchain pfass with current technologies is still not possible this challenge will be discussed in this study by combining membrane technology with cold atmospheric plasma technology membcap the degradation of shortchain pfass and genx which health advisory level has been published recently will be studied using the innovative membcap reactor based on her previous projects and studies er has experience in the measurement and mineralization studies of emerging compounds especially pfas from waterwastewater samples by advanced oxidation processes including cap treatment this study will be successful due to ers expertise in cap treatment as well as the expertise of the host institution which is the leading centre for fabricating membranes in turkey by using both the electrical conductivity and pfas separation capability of the fabricated membrane it is planned to enhance the mineralization efficiency of the cap treatment particularly for shortchain pfas and genx which are difficult to degrade this innovative membcap reactor will provide a great leap forward in waterwastewater purification technology and will significantly progress in the transfer of cap to a large scale
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printable hybrid microsupercapacitor based on 2d inks using graphene tmds and mxenes
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recent tremendous advances in portable and wearable electronics demand lean lightweight and flexible future energy storage devices printable hybrid microsupercapacitor based on 2d inks using graphene tmds and mxenes phys2dgram is mainly focused on printable flexible and portable energy storage devices based on twodimensional 2d materials and their nanocomposites the attraction of phys2dgram relies on the excellent electrical conductivity largescale and lowcost production capability as well as environmental benignity properties of the hybrid 2d materials that will facilitate me to achieve micro supercapacitors with high power and energy densities which will be a great success of the action for the replacement of batteries used in smart garments the main objective is to demonstrate and fabricate flexibleprintable microsupercapacitors from hybrid 2d nanocomposites designs of vertically stacked current collectors electrodes and electrolytes aimed at higher specific energy 10 wh kg1 by controlled multiple pass printing with porous microstructure in interface layers the growth of the energy storage market will be mainly driven by the demand for smart connected energyefficient flexible devices along with the advantage of significantly lowcost methods of manufacture involved in printed devices to highlight research studies are very limited in realizing hybrid mxenetmdgraphene inks for flexible microsupercapacitor which has kindled significant interest and foundation for the phys2dgram all the key components of micro supercapacitors namely electrodes electrolytes and current collectors can be fabricated by inkjet printing through proper formulation and deposition of 2d hybrid inks the broad range of experimental skills and the successful collaborations that i established with other world leading groups put me in an excellent position to deliver this timely high impact research in the action
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smart and flexible separation and valorisation of mixed biowaste from along the agrifood value chain
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mixed biowaste generated along the agrifood value chain is an abundant resource rich in valuable compounds eg polysaccharides or polyphenolic constituents yet its potential as a source of recycled components is untapped 75 of the generated biowaste approx 85 my is landfilled or incinerated constituting 3 of total eu ghg emissionsvalorisation of mixed biowaste from the agrifood sector is hindered by 1 technological challenges of removing impurities eg plastics cardboard or metals that would otherwise decrease the process quality 2 logistics challenges of collecting seasonal geographically dispersed feedstock that lower valorisation costbenefitmixmatters proposes an innovative system that efficiently separates and valorises three types of mixed biowaste streams containing impurities from the agrifood industry wholesale markets greenhouses food and drink industry and obtains six high valueadded outputs powder ingredients sugar concentrates recombinant proteins green fibres bioactive compounds plastic monomersthe mixmatters system is modular and multipurpose able to treat a range of mixed biowaste streams ensuring feedstock supply the separation stage is automated integrating advanced robotics and ai it is also containerised separating the biowaste at waste generation sites to avoid inefficient transportation of water and stream spoilage the system functioning is optimised via a decision support while transparency traceability are ensured via a digital product passportin the project the system will be demonstrated during 15 months at three waste generation sites along with output validation with 6 biobased industries and active involvement of value chain actors partner networks outreach 2280 members to ensure result deployment mixmatters will contribute to meeting the separation targets of the waste framework directive separated 6240 ty by one system at industrial scale
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heterojunctions of topological insulator and metal organic frameworks for thz detection applications
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today xray detection techniques are widely used in the homeland security such as airport surveillance and custom activities and in the medical diagnostics however xrays are ionizing can provoke cancer like diseases and moreover they are unable to detect fabric plastic and concealed hazardous materials the terahertz thz technology has a potential to solve these problems however mainly due to the low photon energy of thz waves it is still difficult to accomplish highspeed and sensitive room temperature thz detectionthe proposed work aims to advance the thz detection technology by exploring exciting optoelectronic properties of topological insulators tis metal organic frameworks mofs and their interfaces i will focus the research on the design and fabrication of heterojunctions consisting of ti thin films and semiconducting twodimensional mofs and on the optimization of their electronic properties and interaction strength with thz radiation to address the enhancement of lightmatter interaction in these novel devices i will vary the chemical composition of mof layers thus enabling the control of their crystalline order and of the coupling between organic and inorganic components tis surface properties will then enhance the charge carrier transport at the interface due to topological protection against the carrier scattering these ingredients will allow tuning and optimization of the photocurrent generation upon absorption of thz photons ie of the photodetection processthe project will answer questions of the physical mechanisms of charge carrier transport in mofs and at timof interfaces and of the key parameters for an enhancement of optoelectronic properties in timof heterojunctions
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youth debunking the gendered arguments of farright extremism
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youdare advances an interdisciplinary programme to study and intervene on the gender constructions of farright youth groups and leaders and their normalisation in the mainstream across 8 countries dk es uk fr hu it ro se the project innovates on the current state of the art in four ways first we challenge existing oversimplifications of farright ideas on gender and adopt an intersectional lens exposing their contradictions and complexities where antigender hypermasculinefeminine tropes go alongside progender equality endorsements within antiimmigration campaigns second we concentrate on the youth which is an understudied group within research on the farright and explore the importance of gender for this demographic as a key avenue of identity formation and politicisation third we focus on farright youth formal leaders at local levels and new types of leadership such as online influencers four we offer a thorough understanding of how farright youth ideas on gender impact on democracy by charting how they inform policy debates and become normalised youdare will also produce methodological and policy innovation a by using qualitative methods to investigate farright youth leadership b mapping online gender controversies engaging farright youth d overcoming methodological nationalism through a focus on local levels and the creation of a transnational network of researchers activists and stakeholders and c conducting crosscutting comparative analyses across the 8 countries and selected localities finally to maximise impact youdare establishes a policy lab as a collaborative platform for policy design recommendation and implementation implementation of policy recommendations generated by the project will be sought through the funding of local level pilottested solutions seeking to minimise the appeal of farright ideas on gender among the youth and thus reduce their impact on democratic values and practices
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rna biology and neuroglial function resolving the cellular and subcellular transcriptome in myotonic dystrophy brains towards new brain gene therapy
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rna biology is critical for the molecular orchestration of the interplay between specialized brain cell types and disrupted rna processing can cause human disease a prime example is myotonic dystrophy type 1dm1 a multisystemic disorder caused by the expansion of a noncoding trinucleotide dna repeat and that involves cognitive impairment and behavioral changes molecular pathogenesis is driven by the nuclear accumulation of rna foci which sequester rnabinding proteins that regulate splicing polyadenylation and subcellular localization of downstream transcripts however we do not know the cell populations molecular pathways and cellcell interactions primarily affected in the brain a critical question to develop effective molecular therapies my host laboratory developed a unique mouse model of dm1 that mirrors the spatiotemporal expression of toxic rna and relevant brain phenotypes using these mice i will fill three knowledge gaps1 i will employ advanced spatial transcriptomics to unravel the vulnerability of diverse cell types throughout brain development and aging2 i will use the trap technology to uncover subcellular transcriptomic abnormalities in specialized neuronastrocyte contacts and identify pivotal disease intermediates of neuroglial miscommunication3 i will use my expertise in aavmediated brain gene delivery to test the capacity of engineered protein decoys developed in my host laboratory to release the rnabinding proteins sequestered in brain cells and correct the behavioral molecular neurobiological deficit in dm1 mice through the integration of cuttingedge transcriptomics with a new focus on synaptic neuroglial communication i will elucidate dm1 brain pathogenesis with unprecedented spatiotemporal resolution and offer a framework to understand other conditions mediated by toxic rna repeats for which dm1 serves as a paradigm simultaneously my project will enhance our understanding of rna biology in the brain
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advanced modelling and characterization for power semiconductor materials and technologies
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the proposed project addmorepower aims to advance xray and electronprobe related characterization techniques to make them quantitative and automated tools for the power semiconductor industry and to refine modelling using moda and fair datamanagement methods to enhance and efficiently use characterization data using chada thereby addmorepower will promote the materials integration and development for european power semiconductor technologies to allow a broader and faster market penetration while also providing new opportunities for other industries basing themselves on mono and polycrystalline materials with the rapid and massive spread of power electronics and power semiconductors to enable the digitalization and the electrification of our society and its supply with sustainable energy new requirements arise to the conception and integration of semiconductor and interconnect materials addmorepower will provide the necessary characterization and modelling techniques that meet the particular needs of the upcoming power semiconductor technology generations1the transition to the new semiconductor materials gallium nitride gan and silicon carbide sic mainly limited by defects in the crystal lattice for which currently no established characterization workflows exist2the starting 3dintegration also of power devices posing severe thermomechanical challenges to the involved metals and intermetallic materials which can only be mastered by understanding gained by predictive modelling3the trend towards digitalization and industry40 which requires fair findable accessible interoperable and reusable data at all development and production stepsthe project brings together renowned research institutes with many years of experience in electron and xray characterization emerging new research groups and company startups and researchers with a track record in multiphysics materials modelling as well as data engineering
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next generation technologies for battery systems in transport electrification based on novel design approach to increase performance and reduce carbon footprint
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the transport sector represents around 25 of all eu co2 emissions to face this challenge the nextbat consortium involving 12 partners from 6 different eu countries and 1 associated partner from switzerland will provide a new framework for standardization of the next generation battery system design that will contribute to speed up a safe and sustainable electrification of transport and mobile applications in the eu thereby also contributing to meet the eu co2 reduction target and to reach a climate neutral economy by 2050 nexbat will significantly contribute to decrease the carbon footprint of the innovative battery system by decreasing production costs thanks to the high recyclability capacity of both hardware and cells components introduced along the production chain 100 ww for hardware 5080 for cells depending on technology the experience and expertise of renowned research centres and smes will allow the development of innovative safebydesign battery systems with increased performances recyclability and interoperability that will reach trl5 by the end of the project the electrification of transport and mobile applications requires highperformance and safe battery system thanks to the new technologies developed within the nextbat framework the battery system performances will be enhanced energypower density increase by 30 50 with decreasing battery weight by 25 using a newly developed lightweight material battery management systems will be incorporated at the cell and system unit allowing to increase battery lifetime by 20 at a soh of 80 at cell level with innovative electronic sensingactuating systems two interoperable prototypes will be manufactured and safety guidelines and methodologies will be established as a result of safety testing campaigns performed by certified laboratories and the endusers whereas dismantling and reuse of bms parts will be assessed along with life cycle analysis
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financing and innovation ecosystems for smes to innovate for raw materials and circular economy solutions and using downstream space technologies
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the european space programme euspace holds vast potential to fulfil the eu green and digital twin transition but smes limited uptake and technological capacity is preventing them from fully unlocking the green and digital transformation fierce aims to address these limitations by mobilising 140 smes startups and scaleups with specialised technical and business advisory to design business solutions and engage in process innovation using downstream space data in areas such as circularity raw materials environmental monitoring and corporate sustainability spaceenabled green solutions we mobilise 25 million eur in financial support providing 70 smes with access to market services and key infrastructure to realise their vision through transformation projects supporting ideation scaling up and commercialization of spaceenabled solutions accelerating smes journey to the market we complement our support for smes with 10 local entrepreneurship initiatives driven by innovation intermediaries and business support networks dihs clusters etc aimed creating more sme opportunities for spaceenabled green innovation through synergies with regional industrial research and market actors and infrastructure providers oitbs we reach further to key euwide networks een sme alliance earsc through our strategic partnership network to create synergies and joint activities to navigate smes and innovation intermediaries towards exploiting highimpact opportunities for funding collaboration and knowledge exchange as well as jointly organized fierce investment tracks in the frame of key industry and business events we deploy the fierce digital toolbox to enrich our support with 50 learning resources 10 practical tools and 70 qualified service providers to create a vibrant dedicated community finally we monitor our performance and impact to design practical replication handbooks to inspire wider application and recommendations for enabling policies
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aiempowered edge cloud continuum for selfaware cognitive computing environments
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next generation enablers such as iot ai and cloud computing open new opportunities to deal with worlds current and future societal environmental and economic challenges however they come with significant data management challenges according to idc the total amount of data generated only by connected devices will exceed 40 trillion gigabytes by 2025 in most of the current systems data storage and analysis happen on centralized locations on the cloud this is pushing network capacity to its limits furthermore centralized storage and processing lead to single point of failure situations which are critically inefficient in case of disasters and crisis our world is continuously living natural disasters health crisis climate change and security threats that show the importance of resilient and energyefficient information systems cognifog targets those challenges and proposes to build a cognitive fog framework to i reduce energy consumption and latency in next generation it systems by reducing the network traffic by analysing data at the edge in a distributed manner closer to where they are generated rather than routing them through the communication networks to a data center ii reduce opex and faster service provisioning by providing a cognitive selfadaptive framework with minimum or no human intervention with dynamic provisioning of computing storage and networking resources along the faredgetoedgetocloud path iii ensure european leadership by providing an open interoperable framework with open apis for application developers to rapidly create and deploy applications benefiting the edgecloud continuum on top of heterogenous iotit systems cognifog will validate project results in three representative application domains critical collaboration missions smart health and smart industry with a consortium of 12 european partners leaders in their domains cognifog will be a cornerstone in the cognitive fog computing domain
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groups of algebraic transformations
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during the last decade spectacular achievements have been performed in the study of groups of birational transformations of algebraic varieties we now have a detailed understanding of such groups in dimension 2 far less is known in higher dimensions but the last five years saw the birth of a large array of techniques that apply in arbitrary dimensions they include powerful tools from padic analysis isometries of cat0 cube complexes pluripotential theory and algebraic geometry simultaneously recent arithmetic equidistribution theorems have been combined with holomorphic dynamics to solve problems of unlikely intersection in the dynamics of polynomial maps and to study parameter spaces of such maps the novelty of this proposal will be to combine these recent advances coming from two active sujectsi propose to develop a global study of groups of algebraic transformations of higher dimensional varieties both from the dynamical and thealgebrogeometric viewpoints i have been developing this program progressively during the last ten years moving to higher dimensions is crucial to broaden the range of applications and is now possible with the advances mentioned abovethe first leitmotif will be the large scale geometry of groups of birational transformations the second will be the dynamics of natural actions of such groups on families of geometric objects notably on families of rational surfaces and on character varieties there a three long term goals a to extend some of the geometric features of linear groups to all groups acting faithfully by algebraic transformations this includes the mapping class groups of closed surfaces for instance b to compare the geometry of distinct rationally connected varieties through a comparison of their groups of birational transformations c to get new properties of families of geometric objects such as rational surfaces via dynamics in their parameter or teichmüller spaces
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networknature scaling up naturebased solutions to achieve 2030 policy goals
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networknature will continue networknatures legacy as a network of networks and expand it to engage new audiences in addressing the societal challenges outlined by the eu it will maintain and enhance the established evidencedemandpolicydriven multistakeholder platform for nbs strengthening partnerships and fostering new relationships around a clear strategic framework for action underpinned by an updated eu research innovation nbs roadmap and complementary analysis of policy opportunities for integrating nbs at eu member state regional and local level in view of eu 2030 policy targets and eu missions networknature will provide scientific nbs insights across selected policy priorities and different european and international contexts this will guide our work around dialogue stakeholder interactions knowledge sharing and awareness raising resulting in products standards and advisory services that support the growing nbs community of innovators practitioners and developers a targeted training and capacity building programme will promote a step change from siloed projectbased thinking towards an integrated systemic and stakeholderled approach to nbs planning design and investment while leveraging the role of ecosystems as critical infrastructure that support regenerative economic activities and help reduce biodiversity loss we will enable regional and europewide transdisciplinary collaboration to answer identified ri needs for nbs via knowledge exchange between eufunded nbs ri projects and stakeholders together with skills development and capacity building for target groups from science policy business and society international collaboration with key strategic partners eg uncbd ipbes ipcc unfccc unep undrr and selected regions will enable european expertise to inform the global nbs discourse contributing to the ecs vision of a stronger europe in the world and supporting new investments for nbs
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improving energy access and climate resilience in africas fringe communities
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we will establish a renewable energy park reep in a rural community fringing the mole national park in ghana to demonstrate energy access and climate resilience using the waterenergyfoodecosystem wefe nexus approach we will replicate a plugandplay microgrid developed under the ongoing horizon project repower using solar photovoltaics pv battery energy storage system bess and biomass combined heat and power bchp to increase energy demand of the community we will develop technologies and activities for the productive use of energy pue using a circular economy approach whereby waste generated from agriculture and food processing serves as feedstock for the bchp plant and cookstoves an estimated 900 million africans have no access to clean cooking and over one million deaths occur annually from use of firewood and kerosene involving mainly women and children we will test and promote the use of improved cookstoves ics that can be easily integrated into the current traditional cooking system this will help to arrest intrusion into the protected wildlife park for fuelwood which has led to widespread deforestation and loss of biodiversity we will use life cycle approaches to measure the social ecoconomic and environmental impacts of the project and cooperate with other leapre and ccse projects to facilitate the adoption of the results across africa we will identify and catalogue sources of funding including public and private investors and international private and donor funding attention will also be given to building local value chains for materials supplies and a skilled workforce for the operation and maintenance of the microgrid and pue components the reep will be fully operational by the end of the project period and is expected to become financially selfsustainable within 5 years our business model will be based on a publicprivate partnership and include other sources of financing such as sale of carbon credits
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circular and dynamic manufacturing supply chain orchestration and optimisation
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circuloos aims to deliver circular manufacturing tools which orchestrate and continuously optimise the supplychain endtoend and comprehensively integrate planning and execution combining these with direct calculation of the product sustainability and circularity profile both internally and with external partners this environment will enable them to configure and execute disruptive circular manufacturing processes for sustainable production that cover the entire life cycle of products which become waste and are recycled in the same or other life cycles to achieve this objective the project aims at deployingcircular endtoend supply chain orchestration of collaborative workflows and connecting planning and execution metrics with advanced and multimodal visualisation dt of supply chains formulated factory processes and product design and analyticssupply chain optimisation that monitors the global across the supply chain and local within the factory processes and executiondynamic sustainability assessment functionalities that ponder the alternative supplychain scenarios varying in terms of materials used processing technologies suppliers involved andor activated circular economy practicessupply chain data spaces for seamless multilevel data flow across the supply chain partners cybersecure and trustworthy data sharing across the supply chain by employing a distributed trusted and efficient identity and access management system together with the associated trust frameworknovel circular business processes will be demonstrated supporting reusing reducing and recycling material in production and consumption systems skills upskilling and reskilling will be provided in ramp and through online courses
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mauve a uv satellite for space science
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we propose building a ready to launch cubesat mauve optimised for the observation of stars in the ultra violet uv spectral window mauve will be designed and built by a consortium of space focused smes and will be capable of observing over tens of different stars during its expected lifetime of 3 years enabling studies of stellar flaring activity and exoplanet habitability the mauve program will demonstrate the potential for cubesats to deliver data to the astronomical and planetary community that complement and enhance the outputs of science satellites built by esa and other space agencies our cubesat will move from trl3 to trl 6 within this project and will prove a 16u configuration for delivering excellent science data while developing the key technologies in the interface with the detector the thermal design and high performance pointing accuracy the project and its subsequent development is based on the basic philosophy underpinning delivery of space 40 capabilities in europe the establishment of privatepublic partnerships with a unique commercial approach to space science data delivery building a global community of scientists with european leadership the delivery of such a complete system on such a condensed timescale will be a breakthrough in the technology available to the space community enabling a new era of space research and exploration
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a holistic approach in patient management and epidemic surveillance through convergence of diagnostic technologies capacity building and stakeholder engagement
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research on povertyrelated diseases prds in subsaharan africa suffers from major technological and nontechnological challenges that prevent high quality healthcare to reach many areas not only their performance but also the affordability manufacturability suitability for low and middleincome countries lmics and deployment of the few available diagnostics are main barriers to ensure good quality of healthcare in subsaharan africa the holicare project aims to tackle such challenges from a holistic perspective by bridging the gap between technological excellence available infrastructures capacity and local uptake of new technologies we have chosen to work with lower respiratory infections as a blueprint for our new approach due to their huge clinical and socioeconomic impact and relevance to the sarscov2 pandemic technologywise we propose a 2tiered digitally interfaced diagnostic approach that will start in the field using multiplexed lateral flow tests for rapid screening and triage followed by a referral to a hospital when needed and a followup detailed diagnosis using a pocinstrument performing simultaneous nucleic acid amplification lamp for pathogen identification and immunoassays for host biomarker quantitation digital and manufacturing infrastructures will encompass these technology innovations to ensure future local product development quality controlled biobanks will be developed for executing reliable clinical studies training and human capital investment will be achieved by focussed and highlevel training activities adoption and implementation activities will pave the way for the proposed diagnostic solutions to be successfully deployed fitting the purpose of the local populations our developments will be scalable adaptable and transferrable to other diseases and national eco systems aiming to contribute to the improvement of healthcare delivery in subsaharan africa
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novel firstinclass specific oromucosal immunotherapy somit to treat celiac disease cd
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celiac disease is an autoimmune indication for which there is no cure only the lifelong avoidance of the disease causing gliadin protein in gluten is available as a suboptimal and cumbersome necessity for cd patients we developed a unique novel combination of antigen gliadin protein probiotic tolerogenic bacterial particles tbps and mouth patch technology to enhance the bioavailability and tolerance induction synergistic tolerizing properties of the tbpantigen combination and the therapeutic effect of the somit concept has been shown in a suitable pig model our somitcd promises to require a shortcourse weekly treatment for less than 3 months in cd patientsthis eic project will allow us to finalize the various preclinical activities and perform phase ibiia clinical study paving the way to closing a codevelopment deal with a big pharma playerafter market entry in 2029 we aim to reach a market share of 15 and generate annual revenues of 148m by 2033
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soft wearable assistive garments for human empowerment
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soft robotics has become one of the fastest growing fields over the last decade and the development of technologies related to the associated modelling sensing actuation and control challenges has flourished as part of the fields impetus soft robots have been demonstrated in diverse applications such as wearable devices mobile or locomotive robots as well as soft manipulators soft lower extremity exoskeletons soft wearable robotics swrs are one of the most challenging research topics and require multidisciplinary approaches involving diverse fields such as neuroscience biomechanics robot control ergonomics and other fieldsswag aims to explore a fundamentally new approach to engineering soft structures that omit fully rigid materials for inflatable ones made from highstrength fabrics and films when manufacturing humanassistive exoskeletal devices that target strainprone segments of the human body ie lower body and core such soft wearable adaptive garments with actuation capabilities offer higher variable stiffness and forcetoweight ratios compared to other existing methods and simultaneously entirely conform to each joints intricate kinematics because of this new design approaches can be used as building blocks to realise complete assistance for multidegreeoffreedom joints such as the ankle or hip by adapting flexible and conforming motions achieved by continuum robot designs swags advances will be demonstrated in 4 different application scenarios the project brings together 13 partners from 5 eu countries and the uk the partners consist of an interdisciplinary combination of leading academics with very strong track records in their respective fields they are supported by rtos with demonstrated capabilities of developing and validating applicationdriven solutions as well as two commercial partners aiming to lead the exploitation of swags outcomes
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guiding multimodal therapies against mrd by liquid biopsies guidemrd
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advancing personalized approaches in cancer therapy aiding identification and adaptation of multimodal treatment strategies for improved outcomes depends on clinical implementation of novel diagnostic technologies for most cancer types the riskfeatures used to select individuals for postoperative adjuvant multimodal therapy are suboptimal where many patients are overtreated and others undertreated liquid biopsy has opened a new diagnostic avenue to detect and monitor minimal residual disease mrd in individual cancer patients especially for selecting patients for multimodal therapies postoperatively however despite many circulating tumor dna ctdna diagnostics being developed there is a lack of standardization harmonization and robust data to demonstrate clinical validity guidemrd is a consortium of leading academics technology companies pharmaceutical companies and experts in multistakeholder engagements together we will tackle the critical questions by developing reference standards for ctdna diagnostics clinically validate promising ctdna diagnostics and develop data to guide the use of multimodal therapies with a noninvasive diagnostic test with robust engagement with regulatory authorities payers and importantly patients themselves we will develop recommendations and guidelines based on objective data to use ctdna diagnostics to guide multimodal therapy selection to improve patient outcomes
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optimising a high efficacy plasmodium vivax malaria vaccine
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plasmodium vivax is the most widespread human malaria with 25 billion people living at risk in south america oceania and asia the revised malaria vaccine technology roadmap to 2030 recognises the severity of p vivax malaria calling for a vaccine intervention to achieve 75 efficacy over two years now equally weighted with p falciparum however if this ambition is to be realised new and innovative approaches are urgently required to accelerate nextgeneration vaccine research and development whilst the few known candidate antigens need to undergo earlyphase clinical assessmenthere we build on exciting breakthroughs in p vivax vaccine research recently pioneered in europe including new transgenic parasite technologies for functional assay development and production of a parasite clone that is safe for use in controlled human malaria infection chmi clinical models the objectives of optivivax will now integrate ambitious multidisciplinary scientific and clinical approaches around the parasites lifecycle and will use our increased knowledge of p vivax immunobiology to further develop nextgeneration vaccines with improved efficacy we will diversify the portfolio of new antigens ready for clinical testing by reverse vaccinology and diversify their delivery with new platforms and adjuvants developed using sustainable and improved gmp biomanufacturing knowhow in parallel the efficacy of known leading antigens will be benchmarked for the first time using innovative design of clinical studies and chmi models making these lead candidate vaccines ready for future field trials improved preclinical functional assays using stateoftheart transgenic parasite lines will also allow for mechanisms of antibodymediated protection to be deciphered the availability of new functional assays and human challenge models will underpin the future framework for informed decision making by the clinical vaccine community policy makers funders and regulators
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responsible time and tech in an accelerated digitised world
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the rosetta programme proposes a transformative agenda to examining the impact of technology in an increasingly accelerated high pressured world rosetta will provide 19 recruited fellows with the highest quality research environment and a training programme that ensures their ability to provide leadership in the sectors relevant to design evaluation and regulation of technology from a time perspective rosetta will be coordinated by the university of galway ireland main beneficiary through lero science foundation ireland research centre for software and involves 4 other irish universities university college cork university of limerick university college dublin trinity college dublin fellows will complete a compulsory secondment at one of 20 associated partners fellows will be recruited from the fields of computer science medicine biomedical engineering education psychology software engineering information systems humancomputer interaction and business management fellows will choose their own research topic within one or more the rosetta themes adding to the truly interdisciplinary nature of the programme rosetta will incorporate international mobility intersectoral exposure and interdisciplinarity fellows will receive training on the latest emerging time theories methods and equipment through five summerwinter schools fellows will be provided with a comprehensive set of courses to improve their transferrable skills to diversify their employment options fellows will have access to lero supports such as workshops and seminars industry collaboration public engagement and communications fellows will be uniquely positioned to design and evaluate technology and policies and legislation on technology use with new expertise and perspectives on how technology affects our time the total budget required to deliver rosetta is 35m we request 18m from the european commission to be matched by 17m from lero and the main beneficiary
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using firstprinciple modeling to study multipolar mitotic spindles in cancerous cells
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targeted research initiative for pole organization leveraging experiment and simulation tripoles the mitotic spindle is responsible for segregating chromosomes into two identical sets prior to cell division errors in the process can result in daughter cells having an incorrect number of chromosomes a disorder referred to as aneuploidy cells with multipolar spindles an aberrant spindle architecture marked by three or more spindle pole bodies rather than the typical two are particularly susceptible to making the mistakes that lead to aneuploidy however relatively little is known about the mechanisms involved in multipolar mitotic spindles or how cells regulate them in this proposal we will develop a new theoretical framework that models multipolar mitotic spindles with an unprecedented level of detail the model will incorporate multiple centrosomes with microtubules emanating from them explicit chromosome pairs with a severable link and different species of motor and crosslinking proteins to generate forces we will first use the model to recreate healthy bipolar spindles then expand it to investigate tripolar spindle dynamics and how cells regulate excess centrosomes our model will use firstprinciple mechanisms which will allow us to make predictions that can be tested in experiment by our collaborators by using theory to motivate specific followup experiments in this way we can uncover novel mechanisms involved in the regulation of mitotic spindles that would otherwise go unnoticed beyond three main research objectives this proposal also includes measures for a twoway transfer of knowledge effective communication and dissemination of results and overall management of the project the work done in this proposal has the potential to not only illuminate how cancer cells regulate their aberrant spindle geometries but also provide fundamental insight into how healthy bipolar spindles transition into unhealthy architectures
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the role of silica in the dawn of life on our planet
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all information humankind has of the ancient past of our planet comes from analyzing the geological record encoded in rocks there is however no rock record of the first 600 million years of earths history unlocking the secrets of this earliest period the hadean is a fundamental task for science as it is key to understanding how the planet became habitable when the first forms of metabolism and selfreplication developed and life appeared the lack of a geological record has led scientists to use computational modeling to make inferences about the conditions in early earths environments less common are laboratory experiments specifically targeted to simulating hadean conditions based on ubiquitous carbonaceous chert deposits in the oldest rock record it is widely accepted that many early archean aquatic settings were reducing and rich in silica and some basic carbonbased molecules we reason that such aquatic conditions were already established during the early hadean and inevitably led to the existence of a largescale factory of simple and complex organic compounds many of them relevant to prebiotic chemistry and to the route to biomimetic hybrid microstructures able to selforganize and catalyze prebiotic reactions relevant to the origin of life our project is aimed at understanding the crucial role of silica in directing the geochemical and protobiological processes creating habitats for early life and preserving early biomass on earths surface during the first billion years of its history protos will use an array of laboratory experiments the hadean simulator to systematically study abinitio reactions of water and gases with the earliest rock types in order to determine compositions of aquatic habitats and subsequent silica precipitation mechanisms organic synthesis processes on silicairon surfaces and the preservation of the first remnants of life protos will change our view of the infancy of the planet
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spin systems with discrete and continuous symmetry topological defects bayesian statistics quenched disorder and random fields
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the main goal of this project is to understand the geometry of the deeply influential topological phase transitions which were discovered in the 70s by berezinskii kosterlitz and thouless the archetypal example of such phase transitions arises in the 2d xy model in which topological defects called vortices behave very differently at small and high temperature the mathematical understanding of this rich phenomenon goes back to the work of frohlich and spencer in the 80s and involves the 2d coulomb gas this project is aimed at analyzing this phase transition through the prism of random fractal geometry by associating natural percolating sets to the xy model whose behavior will depend crucially on the temperature one constant source of inspiration will be the deep geometric content and powerful probabilistic methods gathered over the last 20 years for celebrated discrete symmetry models such as 2d critical ising or percolation new tools will be brought in among which the recent works of the pi with sepulveda which analyze the 2d coulomb gas and make connections with bayesian statisticssince the early days of topological phase transitions topological defects have been found to arise also in some discrete symmetry spin systems as well as in abelian lattice gauge theory in 4d this project will explore the geometry of these by making several novel and fruitful connections with the dimer and ising modelsthe new connections made with statistical reconstruction and bayesian statistics will give access to the even more fascinating and least understood world of spin systems with nonabelian gaugesymmetry finally we shall investigate the mechanisms which relate the microscopic background noise with the large scale structures it induces in the contexts of quantum field theory and kpz fixed point the impact of this project will go well beyond the current understanding of topological phase transitions in a wide variety of settings where they arise
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dissecting the molecular basis of immunological memory in human t cells
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t lymphocytes are essential for immunity to pathogens and malignancies activated t cells can retain a memory imprint of their adversary eg a virus enabling them to respond more rapidly and vigorously to any subsequent encounters while memory t cell formation is critical for successful vaccination and antitumor immunity dysfunctional memory t cells are a common feature of human disease including allergy autoimmunity and cancer t cell activation emerges from changes in gene expression dictated by intricate chromatin dynamics recently 3d chromatin folding emerged as a key regulator of transcriptional control by ensuring correct communication between regulatory elements and their target genes how memory t cells leverage threedimensionally organized chromatin configurations to achieve rapid reactivation of specific inflammatory genes is unclear hence the molecular mechanisms that control and maintain immunological memory remain poorly understood to address this issue i propose an innovative molecular strategy to dissect immunological memory in primary human cd4 t cells that combines cuttingedge genomewide analyses of gene expression chromatin state and threedimensional 3d genome folding with crisprcas9based functional assays this approach will generate the first integrated multidimensional epigenome atlas of a human t cell memory recall response yielding molecular circuits of genes regulatory elements and biological pathways underlying human immunological memory multimodal single cell genomics assays will reveal the nature of transcriptomeepigenome crosstalk in individual t cells and the heterogeneity of memory recall these insights will force a breakthrough in our understanding of how human immune cells maintain specific transcriptional programs for launching rapid and tailored responses upon reactivation and how this feeds into susceptibility to develop disease
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efficient synthesis of highperformance millimeterwave metasurfaces
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fifth generation 5g wireless networks have been introduced to enable significantly higher data rates and lower latency sixth generation 6g wireless networks are also envisaged for even higher speed and capacity in the context of 5g and 6g communications the operation of wireless networks is shifted toward higher frequencies as are millimeterwave mmwave frequencies metasurfaces present an appealing technological solution to realize low cost functional components of simple fabrication especially in mmwave frequencies where component dimensions greatly decrease metasurfaces are the twodimensional planar extension of the wellestablished electromagnetic metamaterials and are capable of controlling and efficiently guiding propagating waves by engineering the properties of individual subwavelength resonators although the most appealing properties of metasurfaces arise in nonuniform configurations the analysis and synthesis of such nonuniform metasurfaces is extremely challenging especially as the size and complexity increase fullwave analysis of the entire structure though highly accurate it requires high computational resources and is extremely timeconsuming in some cases it may even be inapplicable due to the increased computational demand millisurf aims at developing a computationallyefficient and robust semianalytical framework to facilitate the analysis and synthesis of highperformance metasurfaces suitable for mmwave communications combined with novel and highlyaccurate fabrication techniques millisurf will contribute to the field of wireless communications by advancing the existing technological solutions the proposed research will be carried out at the electrical and computer engineering departments of duke university united states and aristotle university of thessaloniki greece
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systemic effects of crises on policymaking in modern democracies
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crispol analyzes the systemic impact of crises on democratic policymaking the fact that crises have turned into ordinary rather than exceptional phenomena in modern democracies may not only erode trust in government crises also spawn additional crises because crisis responses absorb governmental attention problems in policy areas not affected by crises might be neglected this can in turn lead to the escalation of neglected issues into fullblown crises thus increasing the burden on governments to manage an evergrowing number of crises crises might thus trigger a vicious cycle that undermines democratic legitimacy it is the central objective of crispol to study systemic tradeoffs in policy change across sectors resulting from crisis events both theoretically and empirically1 crispol maps crises across policy areas countries and over time it provides an encompassing longterm mapping of crisis events across different policy sectors and countries the project captures all crisis events across six policy areas for 23 oecd countries over a period of 50 years 2 crispol analyzes crosssectoral tradeoffs in crisisinduced dynamics of policy change can we observe crowdingout effects with radical departures of the status quo in crisisproximate areas coming at the expense of policy inertia in more crisisremote ones 3 crispol analyzes crosstemporal tradeoffs in change dynamics are neglected policy sectors catching up when the crisis is over ie is policy inertia during crisis times offset by more dynamic change in postcrisisperiods or do crises have enduring consequences for change dynamics in crisisremote sectors 4 crispol investigates whether crosssectoral and crosstemporal tradeoffs vary across countries do certain countries possess a greater capacity to handle crises while simultaneously addressing other policy areas and which factors contribute to this ability
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motivations experiences and consequences of returns and readmissions policy revealing and developing effective alternatives
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in recent years the returns and readmissions policy has become the preferred solution for the eu and its member states to address migrants living in situations of irregularity yet different actors have raised concerns over the lack of effectiveness of the policy violations of migrants fundamental rights associated with its implementation and the dependency on third countries for its application in the first phase of the project more will provide an exhaustive analysis of the development of the policy and its supporting evidence to understand why it has become a preferred solution and why it has been understood to be ineffective in parallel the project will examine the development rationale objectives supporting evidence and implementation for 6 alternative policies that are or have been implemented in eu member states and the uk the project will look at when and why these are or were implemented and why they have not become the main response to situations of administrative irregularity among migrants in the eu
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biopolitics sovereignty and political conflict
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this project is a philosophical attempt to address the question of political conflict at this time what seems to matter most in the escalation of conflicts around issues like gender minorities and the covid19 pandemic is the biological life of individuals and populations this is problematic for the reason that politics is structurally ambivalent about natural life it is productive and affirmative on the one hand and on the other it is lethal and negative there is a wide agreement that this ambivalent relation of politics to life stems from how biopolitical power intersects with sovereign power the power over life with the sovereign right of death while studies in biopolitics often take this enigmatic nexus as the point of reference for further considerations and subsequently emphasise the imminence of the problems with violence and pacification this project aims to go further than that by drawing upon jeanluc nancys idea of technology as the condition of biopolitics to deconstruct and recast affirmatively the knot of biopolitical power and sovereign power this rearticulation i argue provides a novel angle from which to review the conceptions of resistance and to consider the grounds of political conflict to show the affirmative value of political conflicts i apply my developed concepts to examine populist polarization and neoliberal pacification that beset biopolitical liberal democracies today the 24 months or outgoing phase of this project will be carried out at deakin university under the supervision of prof vanessa lemm i will return to the university of jyvaskyla for 12 months under the supervision of prof mika ojakangas
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