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polarization orientation calibrator for cosmology
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i will enable groundbreaking results for cosmology and fundamental physics thanks to a novel method for measuring the angle of the polarization plane of the cosmic microwave background cmb photons with unprecedented accuracy existing and planned cmb polarimeters looking for primordial bmode signals need an independent experimental method for systematics control on the absolute polarization orientation the lack of such a method limits the accuracy of the detection of inflationary gravitational waves the efficiency in removing polarized foregrounds the constraining power on the neutrino sector through measurements of gravitational lensing of the cmb the possibility of detecting cosmic birefringence and the ability to measure primordial magnetic fieldsmy 5year project will dramatically improve instrumental accuracy by means of artificial calibration sources flying on aerial drones and tethered balloons within sight of the most advanced ground cmb telescopes operating at highelevation angles and farfield distances the calibrators will make use of linearlypolarized microwave emitters optimally coupled to the simons observatory so polarizationsensitive detectors the worldleading cmb project for the next decade the orientation of the source polarization plane will be registered to absolute celestial coordinates by star cameras and ground photogrammetry with arcminute accuracy polocalc will take advantage of my leading role in so and will operate from its site in the atacama desert in chile this project will become a pivot for the field any existing or future instrument in atacama will be able to observe my novel polarization calibrator and future projects will intercalibrate their detectors with the resulting calibrated observations of sky sources polocalc will produce the first experimentallycalibrated data of the polarization angle of the cmb and its contaminants allowing existing and future cmb polarimeters to fully mine the cosmic sky
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embodied imamate mapping the development of the early shii community 700900 ce
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the shii imams played a key role in early islam revered scholars descended from the prophet muammad they posed an existential threat to the legitimacy of the ruling caliphs in the 8th and 9th century ce their leadership defined the quietist yet oppositional imami shii community scattered throughout the islamic empire imami shiism was a key part of the turbulent thesis and antithesis which formed islam and it remains greatly influential until today remarkably there is no comprehensive history of the imamate there are a number of reasons for this central among which are that scholarship on imami shiism has approached it as a doctrinal and intellectual phenomenon however religious groups are also fundamentally social phenomena imbod will result in the first comprehensive history of the shii imamate it will position the imamate as a social phenomenon framing it as an interaction between two aspects which are rarely explicitly theorised the imams and the imami community who recognised them imbod will identify and study the key spheres in which the imams and the imami community operated including the imams household elite arab clans especially the prophets family and the dynasties of the caliphs the network of imamic agents the scholars and the communities who came to be associated with shii islam through kinship conversion and migration imbod will map out overlapping networks of interaction across these spheres and identify key actors and institutions responsible for mediating and performing the imamate in the community imbod will not conceive of the imamate as an essence but as a set of social processes some but not all instigated and controlled by the imams themselves crucially imbod will study these processes as performed spatially and embodied materially by actors and physical objects linked to the imams imbod will enrich islamic history by providing a paradigm for studying how religious authority was embedded in society
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large scale deployment project to accelerate the uptake of hydrogen trucks in europe
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150 trucks from three european truck oems the volvo group daimler ag and iveco will be deployed across eight eu member states each company will develop and deploy 4144 tonne articulated trucks which are specified for the longest haul operation ranges over 600km the trucks will be deployed with over 20 truck operators and operate in a wide range conditions and daytoday operations across 8 european member statesthe trucks will operate on a new network of high throughput hydrogen refuelling stations designed specifically for trucks installed by shell omv total everfuel and linde these will be installed to cover the major tent transport corridors from north to south europe with an initial focus on the regions where the vehicles are manufactured to enable the high level of onroad support that the oems customers rely on the stations will be supplied using green hydrogen from a network of 8 new large electrolysers producing green hydrogen consistent with red ii requirements with associated guarantees of originthe project will create an extensive technical economic and attitudinal dataset which proves the viability of hydrogen as a solution to decarbonising road freight this will be analysed by research partners sintef vtt and element energy to create easily interpreted public report on the performance of the fleet the results will be disseminated to an audience of policy makers to encourage policy change to favour hydrogen truck deployment truck operators to enable future uptake and the wider hydrogen industry to underpin supply chain investmentthese activities will contribute to accelerating the rate and scale of uptake of hydrogen fuelled vehicles in europe preparing the policy fuelling network and end user acceptance for the first series production of these oem vehicles at the scale of 1000s per year per oem from as early as 2026 and full industrialisation 10000s per year per oem around 2030
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the pandemic within tackling brain vulnerability in covid19 at high resolution neurocov
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the covid19 pandemic has shown our health care fragility vis a vis novel pathogens with a global disruption on societal welfare despite the towering success of vaccine development lack of preparedness on integrative clinical and molecular phenotyping has emerged with clarity and highlights the need to scale translational efforts for personalized prevention and therapy of particular concern are the longterm consequences of sarscov2 infection with high and rising prevalence of chronic manifestations referred to as postcovid among these the neurological and psychiatric complications stand out for frequency lack of treatment and devastating impact of their effects at pandemic scale here we tackle the cognitive and neurodegenerative complications of covid19 referred to as neurocovid as a ticking pandemic within the pandemic that requires an innovation leap across disciplines we pursue a multi scalar approach that reaches from epidemiology and mechanistic interrogation of hostvirus interplay at single cell resolution through predictive modelling all the way to validation of biomarkers and repurposed drugs the aim is to anticipate and effectively manage personalized trajectories of neurocovid vulnerability and their impact at population level for this we leverage two leading national health registries and three clinical cohorts to characterize the phenotypic spectrum of neurocovid its risk factors and its socioeconomic burden at high definition we pioneer innovative robotics to scale brain organoid modelling and combine it with single cell multiomics and ai analytics to dissect the principles of the individual host response and render experimentally actionable the authentic genetic backgrounds of differential sarscov2 sensitivity through a substantive engagement of patients collectives and health care stakeholders upstream integration of innovative pipelines streamlines translation and operationalizes precision medicine for emerging medical needs
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handson materials science for education
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crystalline materials are indispensable to modern life and the development of crystal growth processes for novel materials remains an important challenge in materials science and engineering however the knowledge about these processes is limited to very select specialist communities researchers from different fields often use crystals just as products without being aware of the exciting multidisciplinary background of their production processes the handsome project aims to facilitate the integration of this topic in educational curricula at various levels we will adopt a macroscopic perspective on crystal growth starting with heat transfer phenomena and phase changes between solid and liquid states which can be related to many aspects of everyday life such as cooking or weather a modular handson setup educrys will be developed to demonstrate the growth of tin crystals from melt using a process very similar to the industrial production of silicon crystals for microelectronics various sensors will be utilized to measure the temperature or power consumption in the handsome project we envision educrys as a unique innovative educational product for both schools and universities we will follow the principles of open hardware with lowcost components and open source control software to maximize accessibility and customizability the educrys setup will allow the transfer of knowledge from hightech industries and specialized research labs to the classroom while preserving the possibility of handson experience and therefore increasing interactivity in science education the handsome project aims to reach a new level of awareness in the society about the challenges of modern materials science in particular the production processes of crystalline materials their energyefficiency and their environmental impact
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future innovation for pesticide use reduction in agriculture
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agricultural production largely depends on external inputs both for plant nutrition and crop in order to ensure food security while protecting the environment and mitigate climate effect agricultural production methods including the use of chemicalsynthetic pesticides needs to be revised lined out in the european green deal and the farm to fork strategy the reduction of pesticide use by 50 until 2030 should be one element to reach the expected goals in the recent years several scientific studies has been performed to develop strategies and techniques to enable a reduction of chemicalsynthetic pesticides use next to methods like organic farming which omits the use of mineral fertilisers and chemicalsynthetic pesticides but result in lower yields integrated pest management ipm has gained a lot of attention and was subject of national and international research activities advanced ipm is characterised by implementing a high degree of preventive measures to avoid establishment of pests and only resorting to chemical pesticides when there is no other option to avoid severe yield loss however the implementation of ipm at a multidisciplinary level is still lacking due to economic reasons and a low acceptance by farmers therefore a key element of fortuna is to identify and analyse the available methods tools and mechanisms from a biologicalecological technological socioeconomic perspective that unlocks a substantial reduction in use and risk of chemical pesticides and ultimately novel pesticidefree farming practices results and strategies will be discussed with stakeholders along the food and supplychain which could contribute to a transition to a reduce reliance on chemical pesticides while supporting successful yields and enable food security one major point in this process is to identify strategies that have a lower risk of productivity and profitability and profitability losses than other strategies and target the longterm perspectives
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volcan activity monitoring by light cycled dynamic operation of metal oxide gas sensors
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there exists a direct relation between gas emissions and earths dynamics and climate the impact of anthropogenic emissions and volcanic eruptions on the climate are well known and from the opposite the effect of the climate on the volcano activity remains mainly unexplored to develop climatevolcano models and improve eruption predictive models a comprehensive study of volcanic emissions is necessary reference measuring systems which are used by the national civil protection agencies and which one can find in the market are highly sensitive complex bulky expensive and have a high powerconsumption consequently they can only be installed in few specific locations for an accurate spatial monitor of these complex gas mixture emissions however a large number of sensing systems need to be deployed and connected providing the required ubiquity something which is possible nowadays thanks to internet of things iot usually these systems do not need to meet the sensitivity level of the reference instrumentsthe present project addresses the development fabrication and testing of gas sensors for their implementation in iot systems that will be deployed in the close vicinity of volcanoes these devices will be made from advanced and harshresistant metal oxide mox nanomaterials and will be based on an unexplored dynamic mode dm of operation in opposition to the sofar reported dm systems based on temperature pulsing here we propose to use light cycled operation lco in which a single lowpower pulsed lightemitting diode photoactivates the mox which provides the different gas response patterns required for the correct gas discrimination this constitutes an electronicnose and dramatically reduces the number of sensors and power consumption required for gas discrimination the developed devices will be tested towards gases typically emitted by volcanoes and will be benchmarked against reference measuring systems
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metals against leishmaniasis
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metal nanoparticles have shown high efficacy against various pathogenic microorganisms including antibioticresistant strains being a very promising solution for the development of novel therapies leishmaniasis is a neglected tropical disease caused by obligatory intracellular parasites of the leishmania genus in their human host they thrive inside the acidic environment of parasitophorous vacuole of mononuclear phagocytic cells such as macrophages leishmaniasis can manifest itself either through disfiguring skin lesions cutaneous leishmaniasis or by reaching the spleen the liver or the bone marrow visceral leishmaniasis according to the world health organization who it threatens more than 350 million people worldwide there is no vaccine and current treatments are long and difficult based on toxic expensive drugs that are becoming ineffective due to the development of resistance the metaleish project aims to develop a new treatment against leishmaniasis based on biodegradable metal nanoparticles bmps metals such as zn and mg are widely considered biocompatible being biodegradable in the human body moreover they possess antimicrobial properties and an immunomodulatory action due to their small size these particles can reach the parasitophorous vacuole of an infected phagocytic cell and kill the parasite for this purpose zn and mg bmps will be produced through the spark discharge technique then bmps aggregation in pbs or cell culture medium will be optimized if necessary through functionalization or encapsulation steps in order to achieve a stable colloidal suspension to be applied in in vitro assays lastly bmps efficacy against leishmania parasites internalized in phagocytic cells will be accessed and the mechanisms through which they are internalized by infectedmacrophage cells and exert their antileishmania action will be thoroughly described
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implementing innovative methods for safety and sustainability assessments of chemicals and materials particularly at nano level in the european union
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the chemicals strategy for sustainability css has been adopted which aims to tackle the challenge of producing and using chemicals to address societal needs while respecting the planetary boundaries and safeguarding people and ecosystems by dealing with pollution from all sources ec 2019 or com2019640final com2020667 final jrc report this css challenge gets operationalised through the developmentimplementation of two key ri actions 1 the strategic research and innovation plan srip and 2 the safe and sustainable by design ssbd framework consistent with the aims of the call horizoncl42023resilience0121 and bearing in the mind the pressing need to develop new methods or improve current ones to support the improvement of safety and sustainability assessments of chemicals the project implementing innovative methods for safety and sustainability assessments of chemicals and materials particularly at nano level in the european union chematsustain will not only study the quantum effects from a fundamental pointofview by dft means but also by identifying and measuring them through experimental techniques highresolution analysis xps and ups and determining the specific molecular recognition through their interaction with the environment which is a quantum mechanical effect invitro microfluidic invitro and invivo models and proteomics and transcriptomics and methods the obtained information on these descriptors will then be integrated for the development of novel in silico models for prediction ecotoxicity properties of advanced materials finally insilico model prediction results will be combined to develop a new methodology for the complementary use of risk assessment and lca to improve criteria for the ssbd implementation framework the work has been divided in eight work packages and the duration of the project is 48 months
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automated zerotouch crosslayer provisioning framework for 5g and beyond vertical services
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the across project designs and implements an endtoend service deployment and management platform for nextgeneration networks and services aiming at unprecedented levels of automation performance scalability and energy efficiency at its basis the platform is built as a highlydistributed grid of domainlevel orchestrators spread across multiple geodispersed and potentially heterogeneous edge environments overseen by a cloudmanaged multidomain orchestrator the use of standardised communication interfaces fosters separation of concerns events between the two orchestration layers through an integration fabric which ensures compliance with ongoing standardisation efforts the platform is further enhanced with a deep endtoend telemetry to unlock visibility of the intertwined network and compute system states b aidriven intelligence that leverages both the vast number of events originating from the dense iot ecosystem and detailed monitoring data originating from the across telemetry subsystem to generate new insights c fullstack crossdomain zerotouch provisioning via programmable hooks that exploit events originating from raw telemetry and ai processed events and d secure and trusted orchestration mechanisms for trusted computing technologies over large and heterogeneous cloudedge deployments as well as orchestration and monitoring of the security vnfsthe across concept is developed over a federated heterogeneous validation and testing environment that hosts a number of test cases and scenarios for promoting all potential intelligent and trusted zerotouch provisioning processes with different event triggering origins the test cases are carefully designed for being promoted as proof of concept poc project submissions to standards and opensource initiatives targeting but not limited to etsi zsm etsi nfvosm tmf onf
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singlecell sequencing analysis of striatal gene regulatory networks in parkinsons disease
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parkinsons disease pd is the fastest growing neurodegenerative disorder currently affecting an estimate of 7 to 10 million people worldwide the disease is characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of protein aggregates in the remaining ones the loss of these cells leads to a dopamine deficit in the striatum which causes the motor symptoms characteristic of pd and the general malfunction of the neuronal circuitry in the basal ganglia the existing treatment for pd is dopamine replacement therapy with levodopa this drug alleviates the motor symptoms but has a number of side effects loses efficacy with time and does not address the cognitive decline caused by pd in order to gain a better understanding of the disease and open new paths towards an effective treatment the parkseq project will use the latest advanced in singlecell rna sequencing and in situ hybridization to determine which celltype specific gene regulatory networks grns are affected by pd in the striatum to this end i will use singlecell rna sequencing scrnaseq to study postmortem human striatum samples from pd and control subjects under the supervision and guidance of ana muoz a leading expert in pd and scrnaseq studies i will draw from my experience in bioinformatics and in single cell data analysis to determine the cell types and subtypes existing in the human striatum on each subtype i will establish which genes are differentially expressed and considering their coexpression i will formulate putative altered grns then during a secondment period i will join mats nilsson laboratory to validate the scrnaseq findings using in situ hybridization dr nilsson has advanced this technique making it possible to use verify the presence of over 100 genes simultaneously on intact tissue slices this will enable me to verify the pdinduced alterations in the grns suggested by the scrnaseq data
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a federated european fair and open research ecosystem for oceans seas coastal and inland waters
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bluecloud 2026 builds upon the pilot bluecloud project which established a pilot cyber platform providing researchers access to multidisciplinary datasets from observations analytical services and computing facilities essential for blue science core services delivered are the federated data discovery access service ddas the virtual research environment vre and virtual labs bluecloud 2026 aims at a further evolution of its pilot ecosystem into a federated european ecosystem to deliver fair open data analytical services instrumental for deepening research of oceans eu seas coastal inland waters it develops a thematic marine extension to eosc for open webbased science serves needs of the eu blue economy marine environment and marine knowledge agendas bluecloud 2026 in 42 months covers activities at a growing number of federated environmental ris to improve optimise services for uptake of new data sets from a multitude of data originators and for discovery and access to their structured data collections the advanced ecosystem will provide a core data service for the digital twin of the ocean mobilising and making available major additional data resources as validated and harmonised insitu data by means of data lakes the modular architecture of the vre is scalable sustainable fit for connecting additional einfrastructures integrating more blue analytical services configuring more virtual labs and targeting broader groups of usersbluecloud 2026 main kers a fair compliant ddas b open science vre federating multiple einfrastructures c 3 eov workbenches d 5 virtual labs e blue strategic roadmap f dto task forcebluecloud 2026 is coordinated by the same organisations trustit maris counting on the same core team of partners cnr ifremer moi seascape belgium vliz overall it mobilises a solid multidisciplinary committed team of 40 partners from 13 eu countries
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exiled empiricists american philosophy and the great intellectual migration
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in the 1930s hundreds of european academics fled to the united states escaping the quickly deteriorating political situation on the continent among them were a few dozen philosophers from a variety of different schools logical empiricists phenomenologists and critical theorists especially the first group would have a tremendous impact on american philosophy although the local intellectual climate had been dictated by distinctively american traditions such as pragmatism us philosophers soon began to advance views that were heavily indebted to the empiricists thereby transforming the american philosophical landscapehistorians have reconstructed the fate of the exiled empiricists still little attention has been paid to the american context in which their movement came to full bloom this is remarkable since any account of the empiricists success requires an explanation of why the americans were so susceptible to their views what explains the surprisingly positive reception of logical empiricism and why were the americans more receptive to empiricism than to phenomenology or critical theory this project shifts the perspective from the migrant philosophers to the local philosophical climate by 1 quantitatively analyzing thousands of american journal publications and 2 qualitatively examining the archives of dozens of key us philosophers and institutionstoday it seems natural to carve up the philosophical landscape into an analytic and a continental tradition yet few philosophers realize that this deeply engrained distinction is relatively new it first became popular in the united states in the years after the intellectual migration in studying the unique american melting pot of philosophical schools eg pragmatism logical empiricism phenomenology critical theory this project offers a broader unifying perspective on 20thcentury philosophy thereby transcending the schoolbased barriers that have often shaped its historiography
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metal nanoapertures by nanoimprint to enhance single molecule fluorescence detection
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after two decades of parallel developments in single molecule fluorescence techniques and nanophotonics these two fields remain largely disconnected today the aim of the printnano4fluo project is to bridge this gap and bring nanophotonics tools to the end users single molecule microscopists our objective is to develop a new costeffective and scalable nanofabrication approach of nanophotonic devices to enhance single molecule fluorescence detection the printnano4fluo solution offers a unique set of advantages it is lowcost fast scalable and safe while still providing a high optical performance of the final bringing nanophotonics tools to the end users single molecule microscopists is a major element of novelty to break into the physical limits set by diffraction where no other alternative exists today
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dissecting early skinbased immune responses to parasites in controlled human infection studies to design novel vaccines
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parasitic diseases cause considerable morbidity and mortality in povertystricken areas affecting hundreds of millions of lives globally vaccines are urgently needed to alleviate disease and lift the economic consequences plasmodium falciparum malaria schistosoma mansoni and necator americanus hookworms are together responsible for the greatest burden of disease vaccination with attenuated parasites is an efficacious strategy in inducing immunity to parasites in animal models recently we have translated attenuated parasite vaccination to humans in proofofconcept clinical trials in which we protected subsets of individuals from challenge this unique preliminary data indicates a role for the skin as a prime immunological organ based on these findings i propose to create a next generation highly immunogenic adjuvanted whole parasite vaccines ready for preclinical testing we will build on our previous experience with chemical tools to load whole parasites with adjuvants to measure the potency of the new vaccines we aim to measure early skinbased humoral and cellular immune markers which correlate with protection in our samples from prior and novel controlled human infection models we will assess the functionality of antibodies by adapting our current molecular imaging tools to quantitatively analyze movement kinematics of parasites in representative 3d environments resembling the human skin cellular correlates of protection in skin will be mapped using imaging mass cytometry on freshly obtained skin biopsies from experimentally infected volunteers through combined parallel analysis of circulating immune markers by highdimensional flow cytometry we aim to take a comprehensive approach including local and circulating markers to identify protective immune responses this highrisk highgain proposal is aimed to break the impasse in the field of parasite vaccine development and open a novel outofthebox avenue to fill the vaccine pipeline
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imaging ultrafast single particle macromolecular dynamics with xray lasers
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conformational dynamics are crucial for the functioning of most macromolecules and a deeper understanding of these motions holds great promise for future discoveries in biology but it is difficult to probe the structure of macromolecules away from their most stable conformations and timeresolved studies remain limited by the available techniquestoday a new generation of xfels is growing the extremely short pulse duration high pulse intensity and repetition rate of these lasers offer new research opportunities in physics chemistry and biologysince the first xfels were proposed the idea of obtaining images of individual proteins frozen in time has fascinated and inspired many and we have been at the forefront of this quest the combination of advances in xfel technology with esi has brought the dream of imaging hydrated single proteins by xray diffraction within reachcurrently timeresolved studies in solution in the subms range are done through solution xray scattering or spectroscopic methods but they can only provide limited structural information xfels provide a way to dramatically improve our understanding of these timescales this proposal aims to develop the science and technology to make ultrafast singleprotein imaging a reality through a threestep approach i develop diagnostics suitable for nanosized samples ii enable single protein xray diffraction imaging through new sample delivery instrumentation iii perform timeresolved single protein imaging experiments using the unexplored tender xray energy rangeultrafast imaging of macromolecules will reveal new horizons as a singlemolecule method with high timeresolution it enables imaging the structural changes associated with fundamental processes such as enzyme catalysis allosteric signal transduction or even protein folding it also opens a way to record molecular movies and mapping the conformational landscape of isolated macromolecules for the first time
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health economic impact of populationbased interventions for prevention of overweight and obesity
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overweight and obesity account for one eighth of the disease burden and five percent of health care expenditures in europe and cause large societal productivity losses thus costeffective strategies for the prevention of overweight and obesity are urgently needed to assure the financial sustainability of health and social security systems populationbased interventions pbis that change the social and environmental context are promising strategies however robust evidence on their health and economic impact is lacking this uncertainty might lead to inefficient resource allocation and harm for patients and society in ecimpact i aim to 1 quantify the realworld causal effect of two policy relevant pbis on body weight 2 estimate the causal effect of excess body weight on health and economic outcomes and 3 model the longterm health and economic impact of pbis by combining results from aims 1 and 2 i will do so by combining innovative methods from economics public health and epidemiology specifically i will pool data from large cohort studies surveillance initiatives and household panels across europe and use econometric methods that exploit natural policy experiments aim 1 link primary and secondary data sources that comprise granular genetic phenotypic and socioeconomic information and apply cuttingedge mendelian randomization techniques aim 2 and build a simulation model that integrates those estimated parameters in a novel model type aim 3 synthesizing cuttingedge methods from different academic disciplines ecimpact will provide urgently needed evidence for decision makers on the value of pbis that will ultimately improve population health ecimpact will advance public health research substantially by showing that combinations of innovative quasiexperimental and modelbased techniques which leverage the full potential of modern data infrastructures can guide health policy in an efficient and timely manner
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the microbiotarootshoot axis in plant health and disease
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since 450 million years roots of healthy plant are colonised by diverse communities of bacteria fungi and oomycetes which are known to extend host functions by protecting roots from disease or by promoting water and nutrient acquisition more remarkably recent evidence suggests that bidirectional signalling between belowground microbial commensals and distant aboveground host organs is likely critical for maintaining hostmicrobe homeostasis and plant health reminiscent of the critical role of the microbiotagutbrain axis for modulating brain functions in animals we recently obtained evidence supporting the role of the microbiotarootshoot axis for integrating response to microbes belowground and response to light aboveground microbiosis aims at thoroughly dissecting the bidirectional connections between microbial root commensals and shoot developmental processes using arabidopsis and tomato as model plant systems by testing the hypothesis that coevolutionary history between microbial root commensals and their hosts have shaped complex regulatory circuits modulating plant health microbiosis aims at unravelling the physiological relevance of the microbiotarootshoot axis for maintaining hostmicrobe homeostasis and for integrating multiple stress responses occurring in distant root and shoot organs using multikingdom synthetic microbial communities cuttingedge metabolome microbiome and grafting techniques as well as several innovative and advanced gnotobiotic plant systems in which belowground and aboveground organs are physically separated microbiosis has the ambition to 1 bridge the gap between functional biology and ecology 2 decrypt root microbiotadependant regulatory circuits promoting plant health and 3 design synthetic multikingdom microbial communities with modular functions favouring resistance to multiple aboveground stresses
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unraveling the interplay between food intake with endocrine factors in brown adipose tissue activation foodbat
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the last five decades have been characterized by an increase in obesity and cardiometabolic diseases recent predictions indicate that more than 1 billion people will be obese by 2030 worldwide contrary to white adipose tissue brown adipose tissue bat dissipates energy as heat and has been considered an important target for treating obesity and cardiometabolic diseases nevertheless little is known about the interaction between diet of the most important modifiable risk factors for cardiometabolic diseases with bat function to develop new weightloss strategies it is essential to understand how food intake modulates bat function by interacting with endocrine factors and how this interaction affects dietinduced thermogenesis in lean individuals and those with obesityrecent data indicate that dit is associated with bat function and that gut hormones play an important part in the activation of bat during the postprandial phase yet the mechanism remains to be elucidated moreover it is unclear whether dit and coldinduced thermogenesis cit share similar metabolic pathways and how the manipulation of food intake can affect bat and thus energy expenditurethe main aims of foodbat are to investigate how the acute intake of a mixed meal modulates gut hormones to stimulate dietinduced thermogenesis dit and bat oxidative metabolism and to understand how this interplay differs between lean and obese individuals also we will investigate how a cold acclimation protocol affects this interaction to modulate dit in individuals with obesity finally foodbat will unravel the connections and differences between dit and cit by comparing the gene expression and mitochondrial respiration of brown adipocytes stimulated with either nutrient overload isoproterenol or a combination of both these findings will be pivotal for the development of new pharmacological and nonpharmacological lifestylerelated strategies to combat obesity
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enhancing accessibility and sustainability in smart cities and smart buildings the universal accessibility suite initiative
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the universal accessibility suite represents a groundbreaking initiative that aims to revolutionize the accessibility and inclusivity of smart buildings and smart cities by leveraging advanced technologies and innovative solutions like ai bim and gis access aims to create barrierfree environments facilitate smooth mobility and enable equal access to essential services and facilities access aspires to deliver innovations supporting accessible and inclusive design by providing advanced analytics for lifecycle assessments optimizing energy environmental and user comfort aspects incorporating simulationbased testing and compliance with accessibility guidelines for designing userfriendly and safe products and built environments the project aims also to explore the relationship between comfort and energy consumption to promote sustainable practices and incorporates virtual user models and simulation environments furthermore access aspires to deliver innovations supporting inclusive adaptive and sustainable operation of the built environment in order to optimize building operations in an adaptive manner depending on the needs of its users and addresses emobility and micromobility to facilitate accessible and inclusive transportation options a particularly important aspect is the development of an accessibility assessment scheme to define clear and measurable criteria guidelines and performance indicators for assessing accessibility the demonstrators have been grouped under 6 case studies focused on 3 different types of buildings uses cultural heritage buildings people care facilities public services buildings and in 5 different locations in 5 european smart cities bulgaria italy spain netherlands and switzerland in order to maximize impact and address numerous reallife situations 22 partners from 9 european countries will collaborate and provide their expertise and resources within the 36 months of access lifetime
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value chain generator to accelerate the european transition to circular economy
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out of 100 billion tons of resources entering the economy every year from metals minerals and fossil fuels to organic materials only 72 are circled back this is a decline from 91 in 2018 and 86 in 2022 despite over 100 billion eur private and public investments into circular economy in the eu solving this problem can lead to 45 trillion eur of business opportunities 6 million high valueadded jobs and a potential to reduce the global ghge by 39value chain generator vcg offers a promising way to solve those problems by exploiting deep tech and novel approaches to build circular value chains which have emerged as a strategic eu tool to direct decarbonization investments and improve resource efficiency it is a cloud platform that uses ai and big data to digitally and in realtime build circular value chains enabling the exchange of industrial residuals between millions of companies embracing circularity for example 42 million tons of brewers spent grain the main byproduct of the beer brewing process can be turned into raw material for bioplastics biofuel alternative proteins or chemicals which are in high demand in the automotive pharma food and beverages and the energy industries with a roi of 172 for a midsized brewery and ghge savings of 19387 tons of co2 or 5291 tons of carbon annuallyexploring multidimensional synergies between materials technologies and climatefinancial metrics vcg enables businesses to make informed decisions and investments fostering a circular economy that decarbonize supply chains minimizes waste potential to valorize over 100 million tons of residuals by 2032 reduces co2 emissions 64 million tons savings by 2032 and maximizes roi up to 600 to keep the competitive edge adhere to the ambitious environmental goals and succeed in the demanding markets the worlds industry must make complex decisions regarding their value chains in the coming years and this is where vcg can help
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understanding divisions and fostering dialogue among berlins turkish speaking communities
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after 60 years of migration in countless waves germanys turkishspeaking communities are complex and diverse routinely lumped together by policymakers media and the public as turks they in fact encompass a multitude of ethnicities religions classes and political groupings though they live sidebyside they often have little contact and frequently harbour disparaging even hostile feelings towards each other aramizda meaning betweenamong us in turkish draws on methods and theories from a range of disciplines to produce novel highquality research on divisions within berlins turkishspeaking communities it explores the role civil society organisations play in easing and exacerbating those divides previous work on europes large turkishspeaking diasporas including kurds has been mostly concerned with these groups links to turkey or their integration with host populations no detailed study has focused explicitly on how they interact with each other at a time when european policymakers are grappling with the paradox of growing spaces for minority communities but shrinking opportunities for social dialogue the project will use a mix of social science methods including ethnographic fieldwork diaries and interviews to collect rich data to understand divisions within turkishspeaking communities it will foster collaboration with research participants by inviting them to play a role in determining data collection methods and taking an active role in a key nonacademic offshoot of the project this final aspect will take the form of workshop run in partnership with an antipolarisation charity aimed at piloting ways of encouraging diverse groups to engage in dialogue the findings which will be widely dispersed through academic and nonacademic channels will be used to advance theories on diversity and inclusion increase understanding among policymakers and the public and test practical ways to build more united and resilient societies
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a road to remember neural plasticity through the lens of gutbrain interactions
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the fact that the brain is influenced by the microorganisms that make up the gut microbiome substantially widens the scope of how we need to view human neurocognition and behaviour however a clear understanding of underlying mechanisms is scant and mainly grounded in animal work this proposal aims at major contributions towards overcoming these limitations the core hypothesis is that gut bacteria are key in shaping neural plasticity and in this way influence human memory abilities changes in gut microbial signalling may contribute to altered neurocognition in individuals who are genetically predisposed to alzheimers disease memorylanes results will thus also have important implications for an ageing society to systematically test the role of gut bacteria in neural plasticity i will take a strong theorydriven cognitive neuroscience approach under my lead my research team will perform a finegrained analysis of hippocampusdependent memory and plasticity using cognitivebehavioural testing and functional magnetic resonance imaging fmri in healthy adults with and without a genetic risk for developing alzheimers disease concomitant measures of gut microbial community structure will be essential to establish causality we will shape hippocampusdependent plasticity and memory by modulating the gut microbiome with probiotic bacteria in a randomised doubleblind placebocontrolled trial this interdisciplinary approach will answer whether gut bacteria play a role in human neurocognition results will transform the way we understand memory processes building translational bridges to prior animal and future clinical work the insights gained may serve as a blueprint for pushing human gutbrain research to the next level paving the way for potential interventions to alleviate the detrimental effects of altered gutbrain dynamics in genetic risk older age and disease
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agricultural productivity and technology adoption in subsaharan africa
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agricultural productivity is strikingly low in much of subsaharan africa exposing the large fraction of the population who lives from agriculture to low incomes and periods of hunger despite high returns to modern agricultural inputs elsewhere their adoption in the region has been persistently low over the past decades in the absence of adaptation climate change is expected to severely impact the agricultural productivity of subsaharan africa i propose three projects which will significantly improve our ability to understand the effect of modern agricultural inputs for agricultural productivity and encourage their efficient adoption first existing methods for measuring the outcome of interest are notoriously imprecise or costly which is a fundamental limitation for research on agricultural productivity in developing countries i will develop and evaluate an approach to substantially improve the precision with which researchers can measure agricultural output at low costs second existing approaches to encourage the adoption of modern agricultural inputs have had muted success i will test a potentially highly impactful novel approach teaching farmers how to assess the returns to agricultural inputs on their own plots in light of heterogeneous returns to input adoption across plots this promises to encourage the right farmers to adopt the right inputs for their plots and third existing approaches to assess the degree of misallocation of inputs and associated output losses rely on strong functional form assumptions i will leverage the plotlevel estimates of returns generated in the second project as well as the knowledge embedded in biophysical models of plant growth to quantify the extent of misallocation of inputs in agriculture this radically new methodology to quantify misallocation will yield substantially more credible estimates and has the potential to significantly expand the possibilities to learn about the sources of misallocation
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a health technology assessment of a breakthrough technology in the early diagnosis of osteoporosis and other bone related diseases
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osteoporosis accounts for more days in the hospital than breast cancer heart attack and diabetes leading to huge healthcare costs despite this bone mineral density bmd the current gold standard for diagnosis of osteoporosis is insufficient and fails to detect 80 of people at risk of a fragility fracture the porous solution aims to replace bmd as the standard for osteoporosis diagnosis using mobile and harmless quantitative ultrasound technology with our patented intelligent algorithms we can for the first time measure the cortical bone quality down to the microscopic pore level this gives a multifactorial analysis of fracture risk that overcomes the weaknesses of bmd due to the use of mobile ultrasound systems this solution can be used anywhere in or outside the hospital such as primary care facilities it creates the ability to use the technology for prevention via screening and opens unprecedented possibilities for the early diagnosis of osteoporosis
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speak for nature interdisciplinary approaches on ecological justice
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the complexity of current ecological challenges requires to elaborate new methods to understand the way we interact with the environment and to eradicate the anachronistic humancentred conception of nature scientists governments and regulators are asked to create a justice capable to reframe the concept of nature as an active player in line with the notion of ecological justice ej counting on a consortium of 9 international interdisciplinary forefront academic universities and research centers and nonacademic institutions a forprofit company and ngos in eu and latin america speak4nature aims to develop new sociolegal instruments and methodologies to provide a common theoretical and operational basis in social and environmental sciences to give voice to nonhuman beings in legal instances and to contribute to the creation of a shared vision towards the treatment of nature itself useful for the adaptation of the political process to the current ecological challengesin particular speak4nature will aim to so1 conceptualize ej from a multidisciplinary intersectoral and international perspective so2 define why how and under what influence different social sciences extend moral considerability to nonhuman nature so3 map the current social and legal techniques to assert the voice of nonhuman nature so4 empower civil society and stakeholders role in ecological awareness restoration and climate change litigation so5 ensure the uptake of project outcomes by developing practical guidelines and training tools on legal techniques and standards to implement ej principles in disputes over environmental violationsthrough interdisciplinary and intersectoral secondments and knowledge transfer mechanisms speak4nature will increase the skills of the involved staff to foster the study exchange and dissemination of knowledge on issues related to the ecology of law contributing to the improvement of ej standards and policies
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noninvasive patterned electrical neurostimulation of the retina
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retinal implants remain one of the most demanding technologies in brainmachine interfacing state of the art devices have yet to reach the needed performances main barriers are suboptimal stimulation parameters and long development and testing procedures while invasive approaches have yet to achieve the resolution performances needed by million of patients blinded by retinal degenerative diseases noninvasive approaches in the form of transorbital stimulation have received no attention yet they offer potentially dramatically cheaper and easy to adapt and optimize technology the main goal of this project is to advance the field of retina neurostimulation by developing new tools for the study and interfacing with the retina in particular 1 bidirectional electrophysiological interface which can record and stimulate the intact retina in the eye and 2 soft multielectrode arrays for noninvasive stimulation of the retina soft transorbital electrodes will be explored we will use these tools to study the retina in its intact form in animal models and we will implement the gained knowhow in humans to study noninvasive stimulation in this project we will establish a new platform for bidirectional electrophysiological interfacing with the intact retina and we will use it to study the retina in its intact form such investigations have ground breaking nature as they can advance both the fundamental understanding of the retina and improve the manner by which we stimulate the retina to generate artificial vision specifically we aim to record spontaneous waves activity and light sensitive ganglion cells optimize electrical stimulation parameters in the intact retina and ultimately to measure retina responses to transorbit stimulation as the ultimate goal of the project we aim to establish the foundation of transorbital stimulation as a new noninvasive paradigm for functional vision in patient suffering from retina degenerative diseases
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showcasing advanced hydrogen valley in western france
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advancedh2valley aims to accelerate the deployment of renewable hydrogen in the loire valley in france by 2025 and prepare the future largescale hydrogen economy in the european atlantic coastline the project is built on successful first achievements of h2ouest and vhygo valle hydrogne grand ouest two hydrogen ecosystems initiated in 2019advancedh2valley is taking a big step forward in accelerating renewable hydrogen deployment in western france as it will initiate115mw of new production capacities along with innovation to optimize operation process representing 1600t 100 certified renewable h2year by 2028 in line with the delegated act of the eus renewable energy directive2 new hrs with distribution capacity of up to 13tday on rtet network1st hydrogen trucks fleet deployment in france as well as innovating offroad port logistics vehicles and river ferry1st renewable hydrogen supply chain adapted to industrial customers specific requirements in order to quickly decarbonize even the small industrial hydrogen consumptionsinnovations to enhance valley operation multisites coordination optimised truck fillingadvancedh2valley ambitions to be both a lighthouse and an innovation lab for hydrogen valleysthe consortium will strengthen collaborations and synergies between neighboring regions and especially pioneering peripherical maritime regions of the atlantic arc the partners will actively share to them the knowledge generated on the project to foster the scalability and replicability of the advancedh2valley model and to pave the way for the future largescale hydrogen economy in europethe main expected impacts of the project are the direct decarbonization of transport and industrial activities using renewable hydrogen 146t of co2 will be avoided during the 2year operation and 28mt per year by 2036
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development of dualtargeting epigenetic modulators for polypharmacologybased cancer therapy
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cancer is a multifactorial disorder involving different genetic and epigenetic alterations since epigenetic modifications are brought about by multiple enzymes working synergistically multitargeting compounds may be particularly effective to acutely interfere with aberrant processes the simultaneous inhibition of two or more enzymes by a single molecule provides improved therapeutic efficacy compared to singletarget inhibitors along with reduced insurgence of drug resistancethrough this project i aim at developing novel therapeutics targeting protein demethylation and deacetylation for application in cancer therapy i will synthesise and evaluate hybrid molecules inhibiting two enzymes at the same time i will develop two classes of compounds targeting the lysinespecific histone demethylase 1a lsd1 and either protein arginine nmethyltransferase 5 prmt5 or histone deacetylases 12 hdac12 these enzymes cooperate in different pathways that lead to cancer insurgence and progression hence dual targeting represents a successful strategy to counteract tumour growthto achieve the outlined aims i will employ a multidisciplinary approach requiring the fusion of knowledge and tools from medicinal chemistry biochemistry biophysics molecular and cell biology through the employment of cuttingedge synthetic approaches i will prepare lsd1prmt5 and lsd1hdac12 inhibitors which will be assessed through multiple biochemical and biophysical assays i will also employ native mass spectrometry to investigate their mode of action in the context of the multiprotein complexes formed by the protein targets the most promising inhibitors will be evaluated in cellular assays to assess their anticancer properties and their effects on transcriptional regulationthis project will open innovative avenues for personalised therapies and provide additional weapons to overcome drug resistance along with adding new knowledge on the epigenetic mechanisms of cancer
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engineering safe faba beans by targeting the antinutrients vicine and convicine
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faba bean is a highyielding protein crop well adapted to cold climates its seeds contain large amounts of protein antioxidants and micronutrients making it an ideal crop to support the transition toward a plantbased diet however faba bean seeds also accumulate high levels of the antinutritional alkaloids vicine and convicine these alkaloids cause hemolytic anemia favism in individuals with a genetic deficiency g6pd deficiency occurring in 5 of the world population faba bean varieties with reduced levels of vicine and convicine exist but the residual levels are variable causing concern for the food industry the development of varieties devoid of vicine and convicine has been hampered by a lack of genomic resources and insufficient knowledge about their biosynthesis in the cleanbean project i will team up with prof fernando geuflores from the department of plant and environmental sciences of the university of copenhagen i will use recently generated resources to uncover the full vicine and convicine pathway and create faba bean lines devoid of these antinutrients the proposed work involves gene selection through coregulation association strategies pathway elucidation using in vitro and in vivo assays and pathway inactivation in faba bean using the recently published findit technology nongmo the impact of cleanbean will be multifaceted spanning both fundamental and applied research on the basic science side the project will uncover the complete pathway of a nucleotidederived specialized metabolite from plants for the first time on the applied side the project will lead to the creation of a vicine and convicinefree faba bean thus enabling the safe consumption of faba beans by all individuals and helping transform the landscape of sustainable food production
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searching new physics using flavour
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after ten years from the discovery of the higgs boson at cern which established the standard model sm of particle physics as the most accurate description of nature at its fundamental level no direct sign of new physics np beyond the sm has been observed in order to make further progress in highenergy physics it is necessary to improve the precision of theoretical sm predictions and search np effects indirectly by looking for tiny discrepancies with experimental measurements this proposal will make use of a combination of formal and numerical tools in particular methods of numerical lattice quantum chromodynamics qcd to achieve this aim in the context of flavour physics two projects are proposed which have the common goal of improving the precision on theoretical predictions of relevant flavour observables and share the difficulty of being dominated by hadronic effects that require nonperturbative lattice calculationsin the first project i will study the leading electromagnetic and strong isospin breaking corrections to kaon semileptonic decays providing a method to extract the relevant decay amplitudes from finitevolume fv euclidean correlation functions evaluated on the lattice and computing analytically their fv dependence this aims to determine the ckm matrix element vus with subpercent precision and hence to test the ckm matrix unitarity predicted by the sm the goal of the second project is instead to obtain a first nonperturbative estimate of longdistance contributions to the mixing of neutral d mesons which are dominant but poorly known thus representing a limiting factor in the study of cp violation and np effects in this process this will be done by applying advanced reconstruction techniques to fv lattice spectral functionsthis proposal will have a relevant impact on flavour physics and phenomenology delivering new conceptual and algorithmic methods which will provide the foundations for future scientific progress
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mapping literary representations of coercive confinement in ireland from the midnineteenth century to the present
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the main research objective of confined is to define the ways in which literary representations of coercive confinement contribute to irish national memory the project focuses on irish literary representations of coercive confinement from the midnineteenth century to the present under the supervision of prof emilie pine its outputs will include a peerreviewed article in a leading interdisciplinary journal a digital exhibition on coercive confinement a podcast on confinement as well as a monograph proposal submitted to a leading university press by the end of the fellowship these outputs will be enriched by access to unique archival holdings in ucd library the national library of ireland and rt archives i will develop researchspecific skills learned via trainingthroughresearch in collaboration with experts at ucd transferable skills developed through handson training courses at ucd and intersectoral skills gained through prestigious collaborations with raidi teilifs ireann rt and the museum of literature ireland moli while undertaking a short visit at moli i will host an online conference on writing coercive confinement as well as a workshop with key stakeholders and policymakers i will apply for a cost action network on writing coercive confinement strengthening and expanding my networks as well as building towards an erc starting grant application in the immediate aftermath of the fellowship
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mapping intersectionality a conceptual and methodological model for the study of inequalities and discriminations
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intersectionality is a concept that has gone viral in the past decade becoming the most prominent analytical framework for analysing inequality its main premises are that people differently positioned in relation to their gender ethnicity age social class sexual orientation etc experience inequality in different ways showing that the interconnection of specific social positions produces concrete forms of inequality and discrimination that are differently configured in different spaces despite the expansion of this concept there is a lack of theoretical or methodological proposals that characterize how this variability is configured leading to a prevailing use of intersectionality as a vague conceptintermaps aims to make a significant paradigm shift in intersectionality studies by proposing a new theoretical and methodological model that while maintaining the original purposes and motivations of the concept develops a specific framework that can establish a systematization and characterization of intersectional dynamics it includes a new theoretical model for conceptualizing intersectional inequalities from a spatial and emotional perspective the development of new specific methods that combine and integrate qualitative quantitative digital and spatial gis approaches and an empirical application that will follow an intercategorical approach this will allow an analysis of intersectional dynamics in themselves the creation of new indicators of intersectional inequality and discrimination and the establishment of a characterization and mapping of intersectionality intermaps will enable a better understanding of how structural inequalities are reproduced and how they differently affect peoples everyday lives building bridges between feminist and postcolonial theories critical geographies and social psychology and overcoming the divide between quantitative and qualitative approaches in the social sciences
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rethinking work beyond productivism from labour law and its uses
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despite the diagnosis that rethinking work beyond productivism is key for ecological transition research on the future of work is confined to a general and abstract level and therefore remains inoperative this erc aims to elucidate the role that national systems of labour law which define and organise work already play and could play further in the emancipation of work from productivism to think about the future of work we propose to start from present institutions and uses of labour law but which at the margins of the system do already deviate from the dominant paradigm of productivism to then develop by extrapolation concrete and plausible trajectories and policy proposals for the future of work first we will conduct a largescale european comparative survey to map deviant institutions of labour law that support the development of nonproductivist timespaces ie places and moments dedicated to activities that are not productive in the economic sense of the term because they have little or no economic value second we will investigate through indepth case studies whether individuals develop deviant uses of labour law to secure to themselves nonproductivist timespaces beyond the law finally building on these results we will elaborate idealtype trajectories for emancipating work from productivism and develop legal arguments supporting the extension of nonproductivist timespaces supported by labour law based on international european and comparative law as well as empirical data collected throughout the project this erc has the potential to remedy the current scientific bottlenecks in articulating concrete and grounded policy proposals and trajectories for the future of work from a societal perspective it will inform socioeconomic players and political decisionmakers so that beyond their growing awareness of the limits of productivism on a finite planet concrete labour law reforms can be debated and decided upon
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centre of excellence in artificial intelligence for digital humanities
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the centre of excellence coe in artificial intelligence for digital humanities ai4dh era chair is an ambitious initiative in slovenia designed to enhance this european regions capacity to integrate artificial intelligence ai into the research conducted at the university of ljubljana in digital humanities dh this project seeks to establish the university as a leading institution in europe for ai applications in dh through the creation of a coe that combines toplevel ai research with direct engagement and support for dh scholars the coe will foster research excellence and provide tailored training and services thereby increasing the humanities capacity to leverage the many exciting opportunities offered by ai the coe will attract projects and other funding ensuring its sustainability enhancing the universitys research infrastructure and reversing the regions brain drain by attracting researchers to slovenia the ai4dh centre will be created under the leadership of professor antoine doucet who is currently professor in computer science at la rochelle universit france prof doucet has an excellent track record both as a researcher and innovator with many accolades as a manager of research and interdisciplinary highereducation activities
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radiationdetected nmr new dimension for magnetic resonance spectroscopy and imaging
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nuclear magnetic resonance nmr is a powerful spectroscopic technique used in various fields including chemistry biology and medicine however conventional nmr has one big limitation namely very small sensitivity due to a low level of polarisation of nuclear spins and inefficient signal detection by an induction signal in pickup coils my erc starting grant has explored the use of radiationdetected nmr rdnmr in which very shortlived nuclei were used as novel nmr probes bringing up to a billionfold increase in nmr sensitivity such nuclei are produced at a radioactiveion beam facility and are polarised on the fly before being introduced into the sample in this proof of concept project i want to use the advantaged of rdnmr and explore the prospect of turning it into a more easily accessible analytic tool i aim to build a prototype of a modular insert for conventional nmr and mri spectrometers that will allow insitu polarisation of longerlived nuclei that can be acquired commercially the insert will include a sample rf coil for spin excitation betaparticle detectors connections to introduce the hyperpolarising agent and the radiolabelled molecule that will be polarised in situ the insert will be complemented by hardware and software needed for the data acquisition during the project we will also explore the most suitable exploitation path we will refine the end users and end market including a workshop at cern and will investigate the patentability of the results i will collaborate with researchers from university of mainz knowledge transfer specialists and companies active in nmr and mri
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fostering queer feminist intersectional resistances against transnational antigender politics
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antigender politics pose a grave threat to modern democratic formations because they challenge peoples everyday survival bodily integrity and selfdetermination antigender spans the political spectrum and manifests not only in illiberal and authoritarian regimes but also in democracies that are considered liberal and inclusive taking a transnational and intersectional approach resist analyses antigender formations in their complexity and contradictions and explores the effects of antigender politics on the everyday lives of those vulnerable to it and on democracies on the whole resist engages with heterogeneous manifestations of antigender across the eu europe and beyond through eight national case studies belarus france germany greece ireland poland spain switzerland and a transnational case study of people living in exile as a result of antigender persecution resist pursues a mixed methods approach to analyse the production and circulation of genderequality repressive strategies and discourses and their effects on lived experiences and resistances resist innovates methodologically to engender democracy by fostering collaboration between academia and civil society organisations csos especially amongst people who come to be targets of antigender including women and lesbian gay bisexual transgender and intersex lgbti persons if those social groups whose fundamental rights are most at risk of violation by antigender are empowered to resist then entire democratic societies benefit resist centres feminist agency and collaborative knowledge production in a the research contents and results b the methodological design and c the social impact by generating new responsive feminist theories and practical solutions at a time of increasing political disillusionment resist creates hopeful imaginative futures transformative theories and more inclusive worlds
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artificial intelligence for flood resilient infrastructure
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amidst the mounting challenges posed by climate change particularly escalating urban flooding events the institute for artificial intelligence rd of serbia ivi introduces the artifact project focusing on the synergy of artificial intelligence ai and engineering for urban flood resilience recognizing the limitations of existing physicsbased models the artifact seeks to harness ais capabilities to elevate urban flood prediction management and mitigation emphasising the importance of integrating naturebased solutions nbs and ai in urban planning to confront future flood risks notably ivi aims to utilize vast datasets and advanced machine learning techniques to offer indepth realtime analysis concerning climate change impacts by intertwining aidriven solutions and expertise of ivi with engineering prowess from leading eu partners delft university of technology tu delft ihe delft institute for water education ihe delft and hamburg university of technology tuhh the initiative aims to foster advanced strategies in aibased urban flood modelling as ivi positions itself at the forefront of aidriven environmental modelling the artifact project emerges as a beacon of innovation cementing ivis role as a regional leader and research lighthouse in this domain to achieve this artifact will use staff exchanges expert trainings summer schools and workshops to boost the research excellence innovation capacity and visibility of ivi members focusing on esrs and administrative staff the project will gradually shift focus from research to innovationdriven implementation by setting up bluegreen ai hub at ivi as an interface towards the regional ict sector bridging highquality ivi research with thriving regional ict innovation scene with the help of eu partners artifact will put the ivi on the european map of emerging aibased flood and nbs modelling while via bluegreen ai hub ivi will become integral part of regional ict industry
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advancing research and training on ageing place and home
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ageing in place is critical to the future of ageing societies in europe older peoples places are recognised as fundamental to longterm health and wellbeing outcomes a fact that has been magnified during the covid19 pandemic yet critically almost a third of older people in europe experience neighbourhood deprivation a fifth encounter a lack of cohesion a growing number are homeless and approximately 3 million people continue to reside in institutional settings there are significant concerns that efforts are failing to support ageing in place with its development as a field fragmented across disciplines and sectors and with few researchers equipped to tackle this fragmentation innovation in research and policy risks stagnation this is despite the renewed interest and urgency arising from the pandemic in deinstitutionalizing later life residential experiences homeage will institute an interdisciplinary intersectoral and international programme of doctoral training and research that drives the development of new leaders in excellence for the advancement of evidencebased innovation on ageing in place in tackling the three interconnected challenges of 1 needs and systems 2 home and belonging and 3 rights and voice homeage delivers a unique employability and skills development process for doctoral researchers drs ensuring that they can lead the response to current research and policy deficits homeage addresses significant demand for drs who possess essential competencies to overcome challenges concerning europes demographic transition and sticking points in its developing silver economy homeage directly addresses the critical priority of enabling older people to age in a place that is right for them within the whos global strategy and action plan on ageing crucially it also addresses strategic themes in the eu green paper on ageing and key goals within the un sustainable development agenda concerning equity and sustainability
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puzzle cell nutshell waste for sustainable material solutions
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in 2025 around 11 billion tonnes of plastic waste will pollute the environment therefore a circular economy with biotransformation and biodegradation of oilbased plastics is as crucial as implementing biobased and biodegradable materials transforming lignocellulosic waste biomass into commercially valuable green materials is an emerging and promising way to minimize waste substitute plastic and reduce our carbon footprint as a waste resource we suggest walnut shells in which we discovered the interlocked 3d puzzle cells the homogeneity the high surface area and the channels make these cells interesting for transformation into biodegradable bioplastic we plan to dissolve the walnut shells in deep eutectic solvent to separate the cells add water to regenerate lignin and recycle the solvent the result of this closed process circle is a nut slurry as a basis for our materials to tailor and functionalize the composite for different applications we propose to add bacterial cellulose pellicles a waste from kombucha fermentation or produced in bioreactors the pure cellulose fibrils with high tensile strength are an exciting counterpart to the high lignin content pressure optimised puzzle cells with different ratios of the two agriresidues we will tune the material properties for nutplastic and nutleather sustainable energy and resource efficient biodegradable nutmaterials with a low carbon and environmental footprint are envisaged for the packaging and textile sector the project activities comprise 1 development and characterisation of nutleather and nutplastic products at the demonstration level 2 life cycle analysis cost of goods and carbon footprint 3 define endusers market analysis potential industrial partner buisness plan and ip strategy we have a strong project team with highly motivated and experienced members with complimentary backgrounds and a solid wish to prove the puzzle cell performance in sustainable materials
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birdshades business model validation and ipr strategy
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birdshades is a female led startup which develops an invisible window film to save billions of birds worldwidewe have recently successfully produced our first large scale pilot line which we are going to sell in a pilot customer programmewe plan to validate our business model and to improve our ip strategy to ensure and pave they way that birdshades will become one of tomorrows cutting edge deep tech champions which protects biodiversity worldwide
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industrial cluster flexibility platform for sustainable factories to reduce co2 emissions and to enable the energy transition
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the flex4fact project aims to develop an endtoend ecosystem that takes a modular approach to enable flexible manufacturing in industry and create the conditions for the necessary energy transition in which all stakeholders can participate and benefit currently complex process industries and the segment of mixed clusters and distributed renewable energy flows are not covered indeed at least three key elements of the flex4fact approach differ from current offerings 1 enabling industrial flexibility through digital process twinning and machine learning techniques to address complex operational scenarios and exploit the full potential of the selected industrial cases
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residual executive power rexpo eu institutional balance and regulatory patterns after the covid19 crisis
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rexpo investigates shifts in eu regulatory practices following the covid19 pandemic to contrast the pandemic the eu has mobilised unconventional legal tools such as financial assistance cohesion policy or softlaw coordination which fundamentally deviate from the communitymethod as the traditional eu lawmaking process rexpo analyses the impact of this postpandemic landscape on eu governance its central research question asks how the eu response to the pandemic has changed the nature of eu regulation and how new regulatory practices have affected the eu institutional balance in general and eu executive power in particular the project focuses on the relationship between executive power and the unconventional regulatory instruments mobilised to face the crisis it resorts to four empirical casestudies encompassing the temporary recovery instrument nextgenerationeu the unemployment financing scheme sure the distribution of vaccines and softlaw coordination in the field of health policy as these tools are all steered by the commission rexpo argues that they have strengthened the commissions executive functions while moving away from the community method using a historical institutionalist lens rexpo defines this increase in the commissions executive power as residual because it emerged as a secondary result of choices necessary to fight the pandemic and not from an intentional attribution of competences by political leaders rexpo combines empirical and theoretical research and adopts an innovative interdisciplinary approach to shed light on the legal and political consequences of the pandemic for eu governance and eventually for its democratic legitimacy whereas scholarship has focused on the political impact of the crisis and on the legality of the measures adopted these interstitial institutional changes have passed unnoticed however precisely these changes can trigger a transformation of eu executive governance
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joint understanding and analysis of clade i monkeypox epidemiology evolution and immunology in south kivu
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we recently described the novel clade ib mpox virus from kamituga south kivu which fast spread in the region and severe symptoms are the reason for the emergency call for mpox research further information on its transmission origin adaptation the protective serological response from different population groups possibilities to improve frontline treatment and possibilities for early detection of the extent of the outbreak is urgently needed to combat the outbreak the research proposed here is in close collaboration with local researchers and authorities and linked with already established capacity building projects covering drc burundi rwanda and tanzania we aim to 1 determine the adaptation of the novel clade by performing onsite whole genome sequencing on a unique already available isolate collection covering the duration of the outbreak 2 identify the origin of this clade by investigating bush meat and hunters 3 investigate the importance of coinfections and the potential usefulness of realtime metagenomic sequencing treatment guidance 4 determine the extent of the outbreak by serological and pit latrine surveillance in the crossborder regions of drc burundi rwanda and tanzania and 5 determine the specific immunological response to the novel clade from selected populationswe are uniquely positioned to conduct the proposed research as we have the necessary technical skills and competences through ongoing activities all ethical permission are in place to investigate mpox as a disease x scenario and we have established collaboration with crossborder health authoritieswe expect to create knowledge on the evolution and epidemiology of the novel clade information on the expected immune response and novel methods to perform early warning surveillance and improved treatment including of secondary infections almost all data generation and analyses will be performed locally thus also ensuring capacity building for future epidemics
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innovative biogeosourced reused and recycled products coupled with bimbased digital platform for very low carbon construction circular economy energy and resource efficiency
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the built environment and related construction processes are together responsible for up to half of europes greenhouse gas emissions the circular principles can contribute in important ways to achieving the 2050 carbon neutrality target in addition to the zero emissions 2030 target inbuilt proposes and develops 1 a set of innovative design retrofit and construction techniques for both existing and new buildings based on the use andor reuse of locally sourced bio and geomaterials along with reused and recycled components coupled with 2 a digital platform as a multiobjective decisionsupport tool for the optimisation of the integration such materials in buildings this can build an integrated strategy in which sustainability and digitalization are embedded into the construction sector this set of products includes largedsized rammed earth blocks recycled fired and nonfired bricks withwithout biosourced insulation hybrid strawclay boards recycled concrete blocks prefabricated waste wood external and internal wall elements smart windows with recycled glass and biopur frames biobased prefabricated curtain walls recycled waste paper and textile fibre insulation mats biobased recycled insulation sheet panelsinfill and second life pv panels these solution techniques already validated at the lab scale and designed following circularity principles will be upscaled demonstrated and tested in real buildings and optimised using the digital platform in a solid lifecyclebased and social lca perspective a multidisciplinary consortium will support these objectives outcomes will positively impact i european competitiveness of the construction sector in the field of green construction technologies ii decarbonisation of the building stock iii increased digitalisation iv raise resilience thanks to circular economy resource efficiency ecodesign and digitization of the inbuilt innovative systems
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reliable powerdown for industrial drives
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rpodid reliable powerdown for industrial drives aims to develop an automated cloudless shortterm faultprediction for electric drives power modules and power devices that can be integrated into power convertersthereby electrical and mechanical faults of machines and of the power converters driving them will become predictable within a limited prediction horizon of 1224hthis will enable a powersaving shutdown of a larger number of production machines during idle times because a looming failure during the next poweron cycle can be reliably foreseenit will also enable reliable mitigation of dangerous faults in applications using modern powerdevices like siliconcarbide sic and iiivsemiconductor devices like galliumnitride gan
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transformation scenarios for boosting organic farming and organic aquaculture towards the farmtofork targets
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with the farmtofork strategy f2f the eu has set targets of reaching at least 25 of the eus agricultural land under organic farming and significantly increasing organic aquaculture by 2030 the overall objective of organictargets4eu project is to support the achievement of these targetsbased on an assessment of key drivers and lockins affecting the development of the organic sector the project will setup a multiactor process to create possible scenarios for reaching the targets the project is structured into two strands which run from start to finishproduction and markets the project will analyse where increases in organic farmland can be achieved and the socioeconomic impacts of these increases at the level of primary production value chains and markets the project will also provide evidence on the mechanisms that can drive demand for organic food and the impact of changing diets and food waste reduction on mitigating the reduced yields from organic productionknowledge and innovation the project will work towards an innovation ecosystem fit for achieving the f2f targets recognising that the scale of the expansion envisaged will require a transformational approach it will identify knowledge gaps and opportunities to strengthen advisory services it will build capacity and stimulate exchange of scientific and practiceoriented knowledge building on the core organic network it will increase and coordinate ri investment for organicorganictargets4eu will facilitate a multiactor policy dialogue to assess the feasibility of the organic f2f targets and develop policy recommendations for the cap eu organic regulation eu and national organic action plans horizon europe and horizontal legislation on inputs and public procurement the policy recommendations will cover shortterm options up to 2027 the next policy reform from 2028 onwards and a horizon scanning post 2030 for the whole next multiannual financial framework to 2034
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an open innovation ecosystem for exploitation of materials for building envelopes towards zero energy buildings
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building sector is responsible for 40 of energy consumption and 36 of co2 emissions in the eu as nzeb becomes the new standard the role of building materials and smart envelope systems is becoming more and more important exploit4innomat oitb will make available a highend open innovation testbed network for building envelopes including roofs and facades enabling the replication of prototypes in different buildings taking into consideration the tradeoffs between the three sustainability pillars the life cycle stages as well as their impacts enduser market needs for lowcost flexible on demand materialbased solutions which will be assessed through an extensive partnership knowledge on materials characterization and modelling monitoring and process control environmental and assessment regulatory and standardization social acceptance and innovation management realizing for nzeb solutions in order to achieve this target a wide range of expertise has been brought to the oitb covering fields such as open innovation testbeds for nano enabled cement non cement premixes and ceramics advanced coatings and glazing solutions loaded with aerogel fibers pcms and other nanomaterials providing multifunctional properties pilot lines for nanodispersion 3d printing and roboting spraying as well as a network of four real scale living laboratories for nzeb technologies evaluation will facilitate a realization tool for developing close to market technological solutions additionally a semiautomated tool combining bim analysis fast track modelling and simulation will make enable a digital tool for utilizing building blocks structural solar thermal and bipv in order to create a harmonized and aesthetically pleasing urban environment
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resiliencecentric smart green networked eu inland waterways
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renew represents a multidisciplinary group composed of 24 participants from 11 countries of the european union capable of playing a key role in supporting the transition of iwt to smart green sustainable and climateresilient sector to achieve this the project will build on previous results will capitalise on cooperation opportunities with ongoing projects and initiatives and will deliver 1an interdisciplinary iwt resilience and sustainability decisionsupport framework incorporating innovative models for iwt infrastructure networking interdependencies linking to probabilistic risk and safety analyses and resilience quantification resilience index supporting the identification of short and longterm measures that enhance resilience utilising soa building blocks from reference projects 2 targeted innovative infrastructure resilience and sustainability solutions building on autonomy developments and maturing green energy options 3 a green resilient iwt dataspace and generic digital twin providing primarily data sharing between infrastructure monitoring ris and traffic management and emergency systems and climate solutions 4four living labs designed to provide exemplars from a lls focusing on integrated iw and hinterland infrastructure genturban douro corridor netherlands eu network perspectives and a ll addressing specifically inland waterway resilience 5renew outreach and upscale activities designed to maximise impact pathways
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masters of the stone the stonecutters workshops and the rise of the late antique epigraphical cultures thirdfifth century ad
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the stonemasters project aims at exploring one of the most startling problems in the global history of research on collective memory and commemorative practices the transformation of roman imperial epigraphic traditions in the later 3rd c ad and the subsequent rise of the socalled epigraphic cultures of late antiquity the problem has been passionately debated since the 1980s but so far no definite conclusions have been reached in this project the pi argues that the main reason for the transformation is to be ascribed to the dissemination of changes in the elites approach to epigraphy by the workshops of stonecutters and mosaicists and that only a thorough study of workshops can provide us with a complete understanding of the processes underpinning this same transition so far epigraphists of the roman period have had few instruments to draw upon for the purposes of pursuing synthetic workshop studies and have been overwhelmingly captivated by other strands the quantitative research the study of the selfrepresentation the visibility of inscriptions and the viewers culture the pi maintains that a significant leap in our understanding is however attainable through the building of a highly regionalized networkstemma of workshops which will identify workshops of origin for all the inscriptions from the 3rd5th c and through applying the methodologies of workshop studies developed for other craftsmanships and periods in particular for early greek vase painters and for scribes and scriptoria which the pi will adapt to the needs of the graecoroman epigraphy assuming that these new methodological lenses will redefine the field and refocus our attention on the actual actors behind the production of epigraphy artisans and workshops as primary agents of toptobottom cultural transfer then we can anticipate an entire restructuring of our understanding of the way artisans disseminated elitist culture in the lower echelons of society
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belight improving biomedical diagnosis through lightbased technologies and machine learning
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photonics is crucial for maintaining and increasing the competitiveness of eu industry and lightbased instruments are fundamental for noninvasive diagnostics and treatment of diseases delivering huge economic benefits for national health systems artificial intelligence ai and machine learning ml have demonstrated their capability to classify and identify patterns in data achieving reliability levels that are comparable to those of experienced physicians to fully develop the potentials of these technologies belight will provide top level training to 11 researchers in photonic technologies multispectral imaging eyetracking optical coherence tomography multispectral optoacoustic tomography superresolution microscopy and optogenetics that will be complemented with aiml computational imaging and modelling a closetotheclinic approach will allow them to advance the field of biomedicine with the ultimate goal of improving the understanding diagnosis and treatment of diseases in 3 main research areas visual health cardiovascular health and analysis of cells and tissues related to parkinsons and rare diseases using superresolution microscopybelight brings together an interdisciplinary consortium of 7 top academic institutions 3 internationally recognized hospitals and an ecosystem of 7 private companies with complementary knowhow in photonics microscopy aiml medical instruments and clinical research to promote intersectoral synergies belights multiskill training program will provide the researchers with the complete set of skills that are nowadays key for their success in both academic and nonacademic sectors they will gain a broad understanding of how stateoftheart lightbased technologies work a solid knowledge of ml and data processing and will obtain experience in clinical and commercialization processes belight will open for them a wide range of highquality job opportunities
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gut microbiotainduced tregs for inflammatoryboweldisease ibd immunotherapy miti2
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our project focuses on the regulatory properties of a subset of microbiotaspecific tr1like regulatory t treg cells for which we have already shown an unprecedented association with the clinical outcome of patients in various inflammatory diseases for a therapeutic use in inflammatory bowel diseases ibd ibd is a disabling chronic inflammatory process that affects young individuals and causes many lifealtering symptoms and represents a risk factor for colon cancer existing treatments are complex with most people requiring lifelong medications as well as dietary and lifestyle modifications and some requiring surgery in this context the development of new therapeutic approaches appears essential and immunotherapy and cellbased therapy are particularly promising strategies for this diseaseteams from nantes have a strong expertise in the field of human immunology mucosal immunology and immunotherapeutic strategies applied to various pathological conditions including gut inflammatory diseases they recently identified a novel microbiotainduced treg subset associated with good prognosis in ibd patients thus representing a promising candidate for innovative immunotherapeutic approaches based on the limitation to develop immunotherapy approach for human diseases by using animal models due to immune system specificitiesdifferences and ethical considerations we opted for the development of an ex vivo human preclinical model that will reconstitute the physiological complexity of the human gut teams from strasbourg have a strong experience and already setup models of organoids in different pathological systems that will perfectly fit to be used as ex vivo preclinical models for this projectthis proposal aims thus at providing a preclinical package including i the proof of concept that a cellular immunotherapy using the identified tregs subset represents a treatment for ibds and ii the reglementary preclinical in vitro and in vivo toxicity
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evaluating a new stool based qpcr for diagnosis of tuberculosis in children and people living with hiv
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the covid19 pandemic had a devastating impact on tuberculosis tb control in 2020 the number of people newly diagnosed with tb decreased by 18 despite a rising global tb burden intensified efforts to improve tb case detection are critically needed especially in populations in whom bacteriological confirmation is suboptimal such as children and people living with hiv plhiv who have also been disproportionately affected by the pandemic the need for highly sensitive sputumfree diagnostic tools for tb has never been greaterstool4tb an edctp2 funded diagnostic trial began its activities in 2020 shortly after the onset of the covid19 pandemic the study aims to validate a novel quantitative pcr assay utilizing a stool homogenization and dna isolation method that yields a highly sensitive and specific detection of mycobacterium tuberculosis stool4tb is implemented in high tb hiv burden settings of mozambique eswatini and uganda under the hypothesis that it will contribute to narrow the large tb case detection gap by improving tb labconfirmation rates in children and plhiv while proving feasible and acceptable new evidence suggests that this platform has a higher sensitivity when compared to sputum culture and xpert ultra and could have an additive labconfirmation yield of up to 20 stool4tb is also evaluating the qpcr platform as a treatment monitoring tool this assay has the potential to be adapted to a poc diagnostic test which could be easily implemented in decentralized levels of caregiven the impact of the covid19 pandemic on tb notifications at the three participating sites and on several stool4tb core activities we request additional funding to finalize recruitment of participants and achieve the target sample size ensuring full execution of all projects objectives the observed upward trend in global tb burden makes the development of promising diagnostic tools such as this novel stoolbased qpcr more important than ever
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training network for tracking and controlling therapeutic immune cells in cancer
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cancer immunotherapies have been established in a growing number of clinical indications and the pace of development is massively accelerating currently over 6000 clinical trials are investigating immunerelated treatments in oncology especially in combinations it includes both adoptive cellular therapies and immune modulating treatments like immune check point blockade in contrast the understanding of how such therapies mediate their mode of action is still mostly poorly understood in particular the role of distribution and relocation of immune cells after therapeutic interventions remains unknown this is surprising as immune cell interactions are a hallmark of therapeutic immune responses trafic will enhance understanding of immune cell trafficking under therapeutic influence it will open new paths and avenues to treatments boost their efficacy and help prioritizing the plethora of immune therapeutic combinations in the past detailed analysis of cellular distributions was facing technical barriers advances in technologies now permit tracking and visualization of cells in vitro and in vivo at an unprecedented resolution allowing for the first time studies on immune cells under therapeutic influence this emerging field of research has enormous potential and key importance for next generation of researchers in oncology and beyond however experts in this field are missing and this threats european research development and medicine therefore trafic joins forces of 13 academic and three industrial partners from nine european countries to conduct an innovative and interdisciplinary approach combining cell imaging with bioinformatics cell engineering and clinician expertise the network bundles recognised expertise in cancer immunotherapies empowering european research and innovation and ensuring a sustainable cooperation in science and training
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photonic metasurfaces for resourceefficient ultrathin high efficiency tandem solar cells
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the transition towards a society based on 100 renewable energy requires massive deployment of photovoltaics of 3070 tw until 2050 this requires huge amounts of resources while their limited availability is already becoming apparent a major lever to reduce resource consumption is to increase the solar cell efficiency as best single junction solar cells approach their fundamental limits higher efficiency can only be reached with socalled tandem solar cells made of two or more subcells all tandem technologies so far are based on relatively thick absorber layers reducing resource demand compared to single junction devices by efficiency increase there light trapping strategies are used to maximize absorptance close to the band gap of the materials and improve efficiency by few percent relative however by applying advanced light trapping techniques such as nanophotonic metasurfaces ultrathin single junction devices with a 510fold decrease in semiconductor material were realized to reduce resource demand further the concept of ultrathin solar cells must be extended to tandem devices this introduces severe challenges as not only absorption needs to be maximized within the active part but a spectrally dependent light guiding strategy is required metasurfaces have shown the ability to manipulate light eg spectrally dependent however they have never been implemented into tandem solar cells thus the overarching goal of phase is to generate a deep physical understanding of metasurfaces for ultrathin tandem solar cells and to develop process flows to implement nanophotonic structures into such devices with efficiencies above 30 this will proof that the chosen technology pathway can support the urgently needed energy transition more specific the goal of phase is to realize tandem solar cells where the resource demanding semiconductor part is 10 times thinner and thus needs 10 times less semiconductor material than similar existing devices
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security enhancement through heterogeneous data fusion and improved aimlpowered copernicus maritime and border surveillance services
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the copernicus security service css is instrumental to support the european unions security safety law enforcement and international commitments with the european commission advocating for its advancement the ai4copsec project aims to demonstrate the potential of advanced ml and geoai models to provide relevant intelligence for enhancing existing copernicus products and services such as oil spill response illegal fishing alert and create new services intended to support searchandrescue operations and irregular migration detection the project will enhance css services through the usage of selfsupervised deep learning models geomatics and social media data osint extracted from heterogenous multisources data ai4copsec is expected to have a transformative effect on the operational capabilities of eu securitysurveillance and safety by leveraging advances to enhance the timeliness accuracy and relevance of information derived from eo and noneo data sources including the innovative use of thermal imagery for ship detection the combination of satellite automatic identification system ais data with structured data extracted from social media sources and the usage of insitu environmental measurement derived from ais data and iot devices this integration will lead to more effective and efficient security operations environmental monitoring and disaster response ai4copsec is also set to detect anomalies and threat in the maritime traffic and advance ship detection capabilities utilising highresolution optical images and advanced segmentation algorithms to enhance the detection of small vessels independently of the type of material metallic structures wood rubber a critical factor for a comprehensive maritime surveillance in line with the css and the eus maritime security strategy eumss
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brain interchange one srthe implantable neuromodulation technology for stroke rehabilitation
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electrical brain stimulation has been successfully used since the 1990s to treat neurological illnesses particularly movement disorders most of the devices for this novel approach are based on the old pacemaker technology companies are unwilling to take device development risks rely on established tech limiting new therapy developments many neurological diseases are still treated with pharmaceuticals only which has limited effectiveness and causes severe side effects neuromodulationelectrical stimulation research has increased in recent decades additional recording capabilities closed loop therapy expand therapeutic options cortec aims to provide novel implantable tech to overcome the current limitations it enables researchers medical institutions industry to develop new therapies devices we plan to finalise the development of our tech for stroke rehabilitation conduct clinical trials get market approval in 2029 generating 250m in sales in 2030
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effects of socioeconomic inequalities in childhood respiratory infections
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social determinants like parental education and household income have an important contribution to the high burden of respiratory infections in children children from dissadvantage backgrounds tend to suffer from a higher disease burden than their more advantaged peers and are more likely to experience illness and disability as a result the pathways through which social determinants influence childhood respiratory infections are complex and interrelated but in general are driven by differences in exposure and susceptibility to risk factors for respiratory infections that are influenced by the conditions in which children grow up however there is surprisingly little evidence in the literature on the mechanisms underlying the association between social inequalities and childhood infections and their interaction with other earlylife risk factors eg behaviours lifestyle environmental conditions etc the purpose of this project is to explore the social geographic and cultural patterns and the pathways that relate social characteristics earlylife risk factors and childhood respiratory infections in order to understand the burden of such infections in children in europe understanding these patterns and pathways is vital to inform preventative policy and help reduce the unequal child health differences through effective public health interventions the project will use existing data from the eu child cohort network on over 200000 children from 16 european birth cohorts and a novel opensource infrastructure called datashield that allows federated analysis of data from multiple cohorts without the need of sharing the participant level data the primary goal of the project is to provide crucial insights into the role of social determinants and earlylife stressors in childhood respiratory infections with the aim to inform eu policies the secondary goal is to provide to the research community an opensource tool for federated mediation analysis
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new chemical warheads for covalent drug discovery
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over the past two decades the pharmaceutical industry has witnessed an exponential growth in approved covalent drugs the majority of such drugs incorporate a chemical warhead a mild electrophilic reactive functional group that forms covalent bonds in a reversible or irreversible manner with nucleophilic aminoacid residues the aim of this proposal is to assess the viability of a new chemical warhead in the discovery of novel kinase inhibitors
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ecooperated modular highly efficient and flexible multipowertrain for longhaul heavyduty vehicles
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empower addresses in full the expected outcome and scope of the horizoncl52022d50108 topic by delivering two flexible modular and scalable zeroemission heavyduty vehicles ze hdv belonging to the vecto vehicle group 9 62 rigid trucks with a gross vehicle weight equal or above 40 tons one vehicle is powered by a fuel cell fc system and has a driving range of 750 km while the other is powered by a batteryelectric powertrain and has a driving range of 400 km both vehicles will be delivered at trl 8 by the end of the project end of 2026 and are expected to approach the market by 2029 within its technical activities empower willdesign implement and deliver technology bricks 1 a modular vehicle system architecture 2 a modular high voltage architecture 3 a modular lowvoltage ee architecture 4 a fc system with high reliability and extended operational lifetime with a modular energy storage 5 a highly efficient eaxle 6 an optimised thermal and energy management 7 an optimised hvac system featuring co2 as refrigerant and infrared heating panels 8 an electrified distributed braking system 9 digital twin models of the demonstrators 10 an innovative human vehicle interface for optimised control of the vehicle systems featuring vehicletogrid communication and ecorouting 11 a fleet management system for the integration of ze hdv into the fleet 12 an overall lca and tco assessment and 13 the operation of a green hydrogen infrastructure for ze hdvdemonstrate the driving range and realworld operation performance of the two ze hdv in five different longhaul and regional distribution usecases including crossborder corridors between different european member statesthe modular and scalable empower technology is transferable to vecto vehicle groups 4 5 and 10 and it is designed to achieve the total cost of operation parity against the conventional 2020 baseline diesel truck by 2030 targeting a production volume above 10000 vehiclesyear
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flexibility to multisensory contestual information in people with sensory disabilities
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one of the brains main challenges is decoding and integrating information from different sensory modalities to create a coherent perceptual representation in this perspective the study of people with sensory disabilities can be considered a model to investigate the mechanisms behind the ability to modify and adapt behavior to external stimuli when a system is flexible it can modify itself to gain greater benefit based on environmental conditions however when the system does not develop in a typical manner as in sensory disabilities it may be less flexible causing problems beyond perceptual processing and affect aspects of everyday life starting with this assumption flexu unites a novel combination between psychophysics and statisticalmodeling analysis to investigate the flexibilityrigidity of the sensory processing mechanisms in people with and without sensory disabilities the projects main aim will be divided into three specific objectives sos so1 understanding of sensory flexibility in the typical individuals so2 modelling of sensory inputs to predict flexible behavior so3 understanding the influence of contextual information on the flexibility of sensory systems in people with sensory impairment and develop rehabilitative training these objectives will be achieved thanks to the transfer of knowledge between the partner unsyd and the host iit institutions involving advanced expertise in experimental psychology behavioral modelling rehabilitative training as well as solid scientific and clinical collaboration networks the outcomes of fluxu will advance not only our knowledge about human perception and multisensory processing at the scientific level but will help to develop a new rehabilitative training based on multisensory inputs that on a wider scale could improve confidence and quality of life in people with sensory impairments
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impetus
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impetus will support and give recognition to citizen science cs in europe it aims to enable more diverse citizen science initiatives csis to access funding bring cs closer to society and policy makers acknowledge cs role in tackling the greatest challenges of our times and enable csis to contribute to green deal gd and un sdg commitmentswe will achieve this by funding csis through 3 open calls selected on expected impacts volunteer engagement edi openness and quality data we will offer 20k to kickstart 100 csis and 10k to sustain 25 csis addressing pressing needs of the european society each call will have 2 challenges we will convene a citizen panel to define one and provide feedback on our work setting up an accelerator to provide the funded csis with an integrated programme of support training mentoring and resources the accelerator will facilitate peer learning enable csis to contribute to sdg and gd targets and forge connections with quadruple helix stakeholders launching the eu prize for citizen science awarded to csis for outstanding achievements allowing them to continue and expand their work and showcase it to a wider audience we will award 3 prize categories for 3 years outstanding achievements diversity and innovative grassroots projects each time we will reach out to advisors to identify exceptional nominations and to the citizen panel to vote in the grassroots category shaping eu policy in and with cs through horizon scanning anticipatory policy and action research informing policy briefs webinars and workshops with key policy stakeholders the aim is to foster more cs data to inform evidencebased policies and identify future directions in cs policy developing impact assessment tools and assessing the impact of csis and our own framework especially on gd and sdg targets insights will be presented within the wider cs ecosystem and feed into recommendations for national and eu policies
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3d decision support tool for brain tumor surgery
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integrated digital diagnostics can support complex surgeries in many anatomies where brain tumour surgery is one of the most complex cases neurosurgeons face several challenges during brain tumour surgeries such as critical tissue and brain tumour margins differentiation or the interpretation of large amount of data available provided by several independent devicesto overcome these challenges stratum will develop a 3d decision support tool for brain surgery guidance and diagnostics reaching trl7 based on multimodal data processing through artificial intelligence ai algorithms that will be integrated as an energyefficient pointofcare computing tool it will be developed following a cocreation methodology involving key stakeholders and endusers stratum will pursue the following objectives1 to foster advances in personalized medicine based on multimodal data including the emerging hyperspectral imaging modality and ai2 to increase the intraoperative diagnostic accuracy of brain tumours improving surgical outcomes and patients quality of life 3 to reduce surgery time with respect to current neurosurgical operation durations4 to improve current cost and energyefficiency of neurosurgical workflows5 to demonstrate the prototype in a twoyear clinical study in 3 clinical sites including an early health technology assessment 6 to prepare the preliminary business plan and the trl9 roadmap after the project ending an optimized integration and processing of available and new emerging data sources would aid surgeons in timely efficient and correct decisionmaking in tissue removal this would maximize the degree of resection while simultaneously minimize the risk of neurological deficits moreover time efficient surgical procedures not only benefit the patients directly by minimizing anaesthesia time and risks of eg postoperative infections but also indirectly by optimizing resources of the health care system
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social protection and demographic change 1960s1990s
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demographic expertise has become a crucial perspective in debates around the development of modern welfare states since the 1960s many reforms answer to demographic changes eg ageing societies and demographic calculations are now regularly used for the technical construction of social protection policies in public debates demographic statistics also serve as an objectifying rhetoric legitimising welfare state reforms as necessary or inescapable however demography is not a black box what exactly is counted in demographic assessments age sex fertility migration varies a lot between national contexts and historically over recent decades this project examines from a historical and comparative perspective how demography became a core element of modern welfare state policies since the 1960s by analysing three fields of the welfare state oldage pensions programs health care and family policies in three representative european countries france italy and switzerland spade aims to identify which actors and which institutions contributed to making the problem of the demographic sustainability of social protection systems a political priority and which solutions were envisaged the project thus broadens the historiography of the welfare states traditionally marked by approaches from social and political history with novel perspectives from the history of science by combining transnational and comparative approaches and by looking at the origins of the discourse about the socalled welfare state crisis spade cast a new light on the transformations that the welfare state as a whole has undergone since the 1970s
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strongly interacting electrons in synthetic superlattices
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recent experiments on a class of atomicallythin twodimensional materials called moir superlattice systems have uncovered an entirely new and fascinating world of enigmatic strongcorrelation physics and superconductivity this project will develop theoretical models to explain these intriguing experimental observations numerical simulations will play an important role in guiding the theoretical models an overarching goal is also to explore what lessons we can learn from moir materials that advance our understanding of other paradigmatic stronglycorrelated electron materials such as eg the copperoxide superconductorsthe particular objectives of this project are to understand1 the nature of the brokensymmetry orders which appear in different moir materials2 the origin of superconductivity observed in carbonbased moir materials and the role of the repulsive coulomb interaction in the electron pairing mechanism3 whether exotic fractionalized metals are realized in moir materials and their potential role in explaining to the pseudogap regime4 the mott insulating ground states of twisted transitionmetal dichalcogenides and the parameter regimes where these correspond to longrangeentangled spin liquidsthese objectives address some of the most important and longstanding problems in condensed matter physics such as eg developing a theoretical understanding of electron pairing in the presence of strong repulsive interactions and the nature of the pseudogap phase which seems to be ubiquitous in stronglycorrelated materials the results obtained in this project will guide future experiments and enhance the possibility of realizing exotic phases of quantum matter such as spin liquids in the lab the experimental observation of spin liquids in moir systems would constitute a milestone in the field of stronglycorrelated materials
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optical camera communication for satellites
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occ4sat aims to develop an enabling communications technology for the space industry providing a solution to some current needs of the space sector such as the intrasatellite communication links and the reduction of the dry mass of data transfer cables connectors and shielding the project proposes the integration of optical camera communications occ into the intrasatellite environment providing the flexibility of this technology for enabling new unprecedented flexible design opportunities thanks to the inherent spatial multiplexing capabilities of occ its cost efficiency and the possibility of grasping reflections on the inner walls and objects of the satellite to establish nlos linksocc4sat addresses area 2 of the call the project will provide two main technology demonstrators which will be discussed in more detail in the implementation section i an intrasatellite occ network simulator that could serve as a tool for speeding up satellite design while providing performance estimates and ii a physical demonstrator based on a satellite mockup able to showcase the flexibility robustness and performance provided by the occ technologythe projects main objectives are a link range of around 1 m suitable for the mini satellites a data rate above 3 kbps enough for the satellite operation or a mass below 300 g using lightweight cots cameras and discrete led devices to name a few occ4sat will address several relevant challenges related to both the space and communications fields such as the limited power supply weight space and clearances in smallsats or the high spatial multiplexation order of the occ nodes the increase of the data rate and the developed of links based on reflections on the payload surfaces among other
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can blue economy interventions mitigate rural poverty and outmigration in landdrying eastern africa
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coastal and rural villages in eastern africa are more likely to have mitigated or even avoided poverty and outmigration during the last three decades of land desertification and natural disasters when developing a sustainable blue economy providing alternative resources and livelihoods to test this core hypothesis we will rely on a longterm causal inference framework combining satellite imagery artificial intelligence algorithms and spatial matching statistical methods but also multidisciplinary field surveys more precisely blueafrica has the ambition to quantitatively and causally assess on the long term whether i maintaining productive coral reefs through the establishment of fisheries management ii investing in mariculture or iii developing naturebased tourism can be potential transformation pathways on the eastern african coast to improve wealth assets and prevent outmigration when arable land and terrestrial resources are vanishing under climate change four main objectives will be reached1mapping and characterizing all rural socioecological systems rses on the coasts of madagascar mozambique and tanzania but also blue economy activities2building testing and validating artificial intelligence algorithms accurately predicting the level of human poverty and outmigration across space and time in africa from satellite imagery and auxiliary covariates3testing the causal link between the establishment of a blue economy activity and the level of poverty and outmigration in the drying rural eastern africa over a long time period up to 30 years using a spatial matching method between control and treated rses and then fitting several response curve models4identifying visiting and understanding the bright vs the dark spots ie the rses with the highest vs lowest level of economic development and net migration using a deviance approach from model expectations indepth field surveys and statistical comparisons
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in situ growth of thermoplasmonic nanoparticles in microfluidic platforms for modifying stem cell fate
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the overarching goal of plasmostemfate is to enable facile inexpensive and scalable fabrication of thermoplasmonicmicrofluidic nsc culture platforms posing transformational impacts in tissue engineering and regenerative medicine addressing unesco sustainable development goal 3 good health and wellbeing and mission cancer of europes beating cancer plan thermoplasmonic gold nanoparticles can generate localized heat in response to biologically transparent nearir light and their size and shaperelated properties can be leveraged to noninvasively monitor and direct the lineage commitment of neural stem cells nscs this action will deploy and develop unconventional in situ nanoparticle synthesis to form shapecontrolled thermoplasmonic nanoparticles directly inside microfluidic devices the proposed platforms will significantly advance the controlled implementation of micro and nano structures as tools for manipulating nsc behaviors by systematically applying both controlled fluid flows and plasmonic enhanced heating to modulate the cell microenvironment the action will be hosted by prof luis lizmarzn at cic biomagune with prof stephanie seidlits group at the university of texas at austin as a secondment this multidisciplinary action relies on collected expertise in plasmonics bottomup nanoparticle synthesis microfluidics and nsc biology my strong background in in situ synthesis thermoplasmonic nanoparticle characterization and microfluidics offer synergies with the host and secondment for generating new research lines and strengthening collaborations between the two institutions ultimately this action will expand my scientific network internationally enable me to hone my skills in the rational synthesis of plasmonic nanostructures and acquire knowledge in fundamental stem cell biology improve my mentorship expertise and lay the foundation for a successful career as an independent researcher at a top university or research center
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electric breaker hammer transforming the mining and construction industries to zeroemission
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a fully electrical impact hammer leh is proposed in this project in order to address the fundamental limitations from hydraulic breaker hammers hbhs as well as fostering opportunities in regard to electric transformation digitalization digileka and data based business in the construction and mining industries this novel patented technological innovation is based on the tubularic linear permanent magnet motor compared to hbhs leh reduces co2 emissions up to 100 saves energy up to 60 ends oil spills and excessive consumption of hydraulic oil is fully adjustable increases safety lowers noise and tremor levels provides significant lifecyclecost savings 80000 eurhammer in 4 years increases performance and precision and allows adjusting striking sequence this project will result in a totally new approach to hammering process in mining and construction providing a groundbreaking cost efficient digitalized connected safe environmental and user friendly solution
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realtime urban mobility management via intelligent uavbased sensing
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inefficient management of urban mobility leads to congestion with several socioeconomic and environmental adverse effects despite numerous research efforts and deployed technological solutions to address congestion the problem still persists one of the main reasons is attributed to the sparsity and low quality of traffic data unmanned aerial vehicles uavs are an emerging noninvasive visionbased traffic sensing technology that offers economic viability and fast deployment uavs can swiftly and controllably move over disperse locations to capture road traffic data and simultaneously measure multiple traffic parameters despite these advantages their applicability has so far been limited to occasional surveillance of road networks for live video monitoring or the extraction of historical traffic data uranus proposes realtime dynamic and continuous uavbased sensing of vehicular and pedestrian traffic and the use of the collected information for um management the envisioned paradigm features a intelligent spatiotemporal sampling from uavs b the generation of complete spatiotemporal measurement sets with quantified uncertainty c the development of suitable methodologies to close the loop by jointly controlling the urban mobility um and uav networks for enhanced um performance and d the strategic selection of measured parameters in this context uranus will design a solid framework for realtime urban mobility management targeting both vehicular and pedestrian traffic the developed framework will include um monitoring um control and uav operational planning methodologies exploiting the unique uranus sensing characteristics success of this project will transform our understanding of joint optimization between sensing monitoring and control not only in um management but also in other uavcentric fields such as air pollution monitoring
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better realworld healthdata distributed analytics research platform
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in recent years datadriven medicine has gained increasing importance in terms of diagnosis treatment and research due to the exponential growth of healthcare data the linkage of crossborder health data from various sources including genomics and analysis via innovative approaches based on artificial intelligence ai will enable a better understanding of risk factors causes and the development of optimal treatment in different disease areas nevertheless the reuse of patient data is often limited to datasets available at a single medical centre the main reasons why health data is not shared across institutional borders rely on ethical legal and privacy aspects and rulestherefore in order to 1 enable health data sharing across national borders 2 fully comply with present gdpr privacy guidelines regulations and 3 innovate by pushing research beyond the state of the art better proposes a robust decentralised privacypreserving infrastructure which will empower researchers innovators and healthcare professionals to exploit the full potential of larger sets of multisource health data via tailored made ai tools useful to compare integrate and analyse in a secure costeffective fashion with the very final aim of supporting the improvement of citizens health outcomesin detail this interdisciplinary project proposes the cocreation of 3 clinical use cases involving 7 medical centres located in the eu and beyond where sensitive patient data including genomics are made available and analysed in a gdprcompliant mechanism via a distributed analytics da paradigm called the personal health train pht the main principle of the pht is that the analytical task is brought to the data provider medical centre and the data instances remain in their original locationin this project two mature implementations of the pht padme and vantage6 already validated in realworld scenarios will be fused together to build the better platform
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secure and sustainable supply of raw materials for eu industry
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s34i will research and innovate new datadriven methods to analyse earth observation eo data supporting systematic mineral exploration and continuous monitoring of extraction closure and postclosure activities with the aim to increase european knowledge and autonomy on raw materials resources s34i uses eo not only for the management of technical and environmental issues for a green transition but also to support minings social acceptance slo and better legislation innovative eobased productsservices will provide new or more accurate rm mineral mappingexploration environmental and mine monitoring and mine safety at different phases of the mine life cycles34i will exploit copernicus and other satellite sensors optical and radar while other platforms as airborne lowaltitude platforms groundbased insitu techniquesmethods and fieldwork will serve either for calibration validation or to complement copernicus data especially at the very high scale spatial or spectral resolutions34i will provide 6 new open high added value datasets 14 new methods to analyze eo data using artificial intelligence being utilized at different phases of the mining life cycle 3 new prototyped eo based services for mining stakeholders 1 research and innovation agenda on eo for mining a set of recommendations for better policy and guidelines for eo uptake by the mining industry s34i results will be validated at six different locations in different phases of the mining lifecycle i land exploration in spain ii coastal exploration at the iberian peninsula atlantic coast iii extraction phase in austria and iv closurepostclosure phase in finland and germanys34i is an eu wide interdisciplinary and complementary team embracing partners from 13 countries and with a 5050 balance between industrial and research profiles s34i mining stakeholders will lead the path towards mining decarbonization while creating social and economic impact through eo uptake
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highly ionized trapped 229thoriuma new paradigm towards a nuclear clock
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among the more than 3000 nuclides that are naturally occurring or that have been artificially synthesized thorium229 is truly exceptional its remarkably low excitation energy makes it the ideal candidate for nuclear frequency metrology surpassing current atomic clocks such a nuclear clock opens doors to fundamental physics testing timevariations of constants and exploring the enigma of dark matter within hithor a conceptually novel methodology towards such a clock is proposed eventually leading to a noelectron barenucleus clock with trapped fully ionized 229th90 where all external perturbations from surrounding electrons are absent highlyionized 229th will be established as a distinctive laboratory for scientific explorations at the interface of atomic electrons and the nucleus by adding a single electron to the nucleus the unique effect of nuclear hyperfine mixing nhm is unlocked induced by the strong magnetic field of this one electron a vast acceleration of the nuclear decay by up to a millionfold is triggered hence for oneelectron 229th89 laser excitation of the nucleus as well as the reemission of photons are each enhanced by up to this factor of a million to date laser excitation of the nucleus hasnt been accomplished nhm will help to overcome this obstacle and exploited as a booster towards 229th laser excitation and a corresponding nuclear clock hithor will be realized at the ion storage and trapping facilities at gsi in darmstadt the only laboratory worldwide where highly ionized 229th can be synthesized in flight decelerated and finally trapped at rest at gsi and its helmholtz institute jena i will bring together the extraordinary expertise of inhouse scientists from the various disciplines required to tackle the challenges initial experiments will pave the path towards highprecision vuv laser spectroscopy of few or noelectron 229th and ultimately towards a singleion quantum logic nuclear clock
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the first wide range flow sensor to unlock microfluidic cell analyses for preclinical studies
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there is a critical need to improve the diagnosis drug discovery and development pipeline to increase the success rate of new therapeutics as low as 34 for cancer drugs and provide earlier detection and treatment microfluidic cellbased assays and analyses are one of the most promising strategies supported by direct feedback from industry and regulatory agencies integrated microscale fluidics adds an extra dimension to in vitro cell cultures and is an enabling technology of single cell analyses and nanotherapies however the main limitations with these platforms expressed by our clients from academia and industry are their inability to measure and control flow rate over a wide enough range 100times too narrow imprecision and failure to detect sensor drift that leads to experimental error our galileo flow sensor innovation demonstrates the technical ability to address these pressing requirements for microfluidic cell assays and analyses this proposal will advance the proof of concept to a viable demonstrator of the technology for beta testingthe timing is ideal for our solution expressed end user demand is high and legislative bodies have voted to reduce animal testing by 2035 galileo has strong competitive advantage in the microfluidic flow sensor market with a sam of 535 mil euryear increasing with the growth of nextgeneration sequencing and genomic medicine elvesys is an entrepreneurled microfluidics instrument company with demonstrated success in the development and commercialisation of 15 instruments for microfluidic flow control and the generation of 10 growing spinoffs in the last 11 years our end user feedback and iterative testing approach to innovation puts us in a position of strength to execute an optimal productmarket fit targeting market creation we have the proven technical expertise to deliver on galileo performance and the market contact breadth to disseminate exploit and communicate the technology to all stakeholders
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bottomup manufacturing of artificial antitumor t cells
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t cells play a central role in antitumor immune protection while their ability to target and eliminate emerging tumor cells is increasingly recognized fullyestablished tumors can efficiently evade t cell response significant efforts spanning several decades of research have been made to develop t cellbased therapies manufactured from donorderived t cells the use of tumordirected t cells engineered to express chimeric antigen receptors cars represents to date one of the most successful applications for treatment of chemoresistant cancers however several major drawbacks including economic factors suboptimal functioning and lifethreatening side effects are still hindering the full potential of t cellbased therapies to address this issue we aim to generate artificial t cells artcell that will mimic the antitumor function of a t cellbased therapy but in a safer more efficient and less expensive product artcells will incorporate two key features of activated t cells into giant unilamellar vesicles guvs the specificity of tumor cell recognition and the cytotoxic activity achieved through death ligands and cytolytic proteins functionalization of the guvs will be confirmed by immunofluorescent labelling of membrane proteins ie trail lfa1 and car and detection with flow cytometry the morphology of artcell will be monitored via cryoem sem and confocal microscopy the ability of artcell to target and kill tumour cells will be thoroughly validated in vitro by a combination of functional and high resolution live imaging assays as well as in vivo with two cell line and patientxenografts mouse models the artcell could allow to circumvent many of the current technological limitations that hinder a more widespread applicability of cellbased therapies without being subject to tumormediated inactivation
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tailoring lattice oxygen and photoinduced polarons to control reaction mechanisms and boost catalytic activity
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photoelectrochemistry can revolutionise our way of life by harnessing sunlight to produce renewable fuels and chemicals and by helping us preserve the planet for future generations however enhancing the efficiency and selectivity of photoelectrochemical pec reactions remains a challenge especially for the phototransformation of organic compounds required in industry the problem stems from the difficulty of characterising the catalytic interface of heterogenous systems under working conditions this prevents us from elucidating the reaction mechanisms and so far has dramatically limited our ability to control reactivity in a similar way to what can be achieved with homogeneous molecular catalysis a particular challenge of solids is that they are prone to form defects during catalysis however how defects and lattice distortions impact the steps of the catalytic cycle remains unknown such mechanistic understanding is critical to redesign new materials and boost catalytic efficienciesphotodefect will address this gap in our understanding by applying new methodologies to the study of oxidation reactions at metal oxide photoelectrodes our approach is to combine operando mass spectrometry and electrochemistry with optical and xray lasers to provide unprecedented insights into the polarised interface our strategy is to detect in situ the formation of reactive intermediates defects and catalytic products in order to map out reaction mechanisms and establish ways to control them on demandwe will use cuttingedge methodologies to establish whether defects and photoinduced structural distortions or polarons participate in the steps of the catalytic mechanisms most importantly if successful our results will reveal new ways to tune the yield and selectivity of pec reactions by controlling defects and polarons these results will influence the way we synthesise pec materials and the theoretical models we use to understand reaction mechanisms
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quantummechanical modeling of the dissociation of hydrogen bonds
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hydrogen bonds are everywhere in nature and they are important in many fields of science wellknown examples come from biology helix structure protein folding enzyme docking chemistry solvation structure and properties of water and atmospheric science nucleation and growth of aerosols today the spectroscopic features of hydrogen bonds are relatively well understood but much less is known about the associated ultrafast dynamics the theoretical models that are used to understand and design present ultrafast experiments are often based on classical or semiclassical approximations to describe the movement of the nuclei with the recent advances in both theory and ultrafast imaging techniques we believe that the time is ripe for a full quantum mechanical picture of hydrogenbond dissociation a quantum mechanical picture of hydrogen bond dissociation will contribute to the basic understanding of chemical biological and atmospheric processes in this project i will perform a comprehensive quantum mechanical study of the hydrogenbond dissociation dynamics of a small hydrogenbound complex pyrroleh2o the calculations will be performed in a reduceddimensional framework for which the central hypothesis is that certain vibrations dictate the dissociation process while other vibrations serve as spectators the dissociation process will be initiated through an infrared excitation that provides just enough energy to dissociate the complex but not enough energy to initiate other unwanted processes we will establish how the reaction mechanisms for hydrogenbond dissociation manifest themselves in the ongoing ultrafast dynamics experiments performed in the controlled molecule imaging cmi group the calculations will be tailored to design and simulate realistic experiments and to facilitate the analysis of the experimental results
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random matrix and integrable systems
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the main topic of this proposal is the study of the statistical mechanics of integrable systems a particular class of dynamical systems for which the behaviour is fully predictable from the initial data all relevant information about the dynamics is encoded in a particular matrix l called lax matrix we want to compute the maximum amplitude for the solution of the ablowitzladdik lattice and the correlation functions for the volterra lattice and the exponential toda one the first quantity is instrumental to study the phenomenon of rouge waves formations and the second one to compute transport coefficients of specific lattices to compute these quantities we need to obtain the distribution and the fluctuations of the eigenvalues of the lax matrix when the initial data are sample according to a generalized gibbs ensemble thus the lax matrix becomes a random matrix to study these objects we use large deviations principles furthermore we also considered the focusing ablowitzladdik lattice the focusing schur flow and the family of itohnaritabogoyavleskii lattices the eigenvalues of the lax matrices of these systems when the initial data is sample according to a generalized gibbs ensemble lay on the complex plane we plan to compute the density of states and the joint eigenvalues distribution of the random lax matrices by using the inverse scattering transform that is a canonical transformation between the physical variables and the spectral variables of the lax matrices the hermitization technique and the brown measure characterization in the end thanks to this analysis we will be able to define some new random matrix ensembles on the complex plane for which it is possible to compute the eigenvalues distribution and the joint eigenvalues density explicitly so we will define some new betaensembles
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tackling seismicity at etna using repeating sources relocations and ambient noise monitoring
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our understanding of processes governing effusive and explosive eruptions has improved over the past decades but understanding the nature of eruptive activity using seismicity is poorly constrained volcanoes produce a wide range of unique seismic signals providing information on source depth fluid migration and subsurface processes and structures hence volcanic seismicity is a useful tool used by observatories to understand activity throughout eruptive and rest periods many volcanoes show a mixture of explosive and effusive activity proving difficult for hazard assessment and risk mitigation due to the differing impacts of eruptive style mt etna is one of the most active volcanoes in the world and produces a range of eruptive styles with eruptions varying in length from days to months records of eruptions at mt etna date back to 1500 bce with a noted increase in volcanic activity over the past 30 years this high eruptive rate longevity and variations in eruptive style provides an ideal location to understand links between eruptive processes and seismicity a substantial seismic network operated by ingv has been in place since 2000 providing a vast catalogue of seismicity the proposed project terra will work alongside ingv to tackle seismicity at etna using repeating sources relocations and ambient noise monitoring repeating earthquakes are spatially localised groups of events that are commonly recorded at volcanoes with each type of signal ambient noise monitoring will allow a continuous record of velocity changes through several eruptions this will complement results from relocated and categorised seismicity to further develop understanding of processes before eruptive episodes the objective of this proposal is to provide novel quantitative constrains on the relationships between seismicity and volcanic processes that govern eruptive styles at mt etna by looking at the temporal evolution of seismicity since 2000
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spatiotemporal regulation of centriolar satellite homeostasis
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membraneless compartmentalization has emerged as a powerful yet mysterious process for the spatiotemporal control of fundamental cellular processes how the identity of a membraneless organelle is established maintained and dynamically altered remains unclear in this project i will investigate the fascinating biology of the centriolar satellites hereafter cs a vertebratespecific membraneless organelle cs was first discovered as granules that cluster and move around centrosomes major microtubuleorganizing centers of animal cells recently my lab and others have placed cs in a new pathway for targeting proteins to centrosomes and cilia and identified an important role for cs in cell division cellular signalling and neurogenesis while cs functions shone light in these organelles little is known about their own biochemistry and how that affects their functionrecent studies including my own revealed unique and intriguing cs properties that likely underlie the rules underpinning their regulation and function the properties of cs granules are regulated in space time and tissue as we observe differential size and composition within the cell and in different cell types building on these discoveries i hypothesise that cs perform its different functions by acting as adaptive organelles that remodel its granule features in response to intrinsic and extrinsic cues with this project i propose to investigate the molecular basis of 1 cs scaffold assembly and disassembly 2 cs granule size composition architecture and dynamics and 3 cs heterogeneity within a cell and in different cell types this project will combine in vitro reconstitution imagingbased assays a new satellitegfp mouse and our expertise in proximity proteomics and biochemical purifications our results will have broad implications in unveiling how cells organize its cytoplasm in time and space appropriate to its differentiation status environment and organismal health
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quantitative analysis of endosomal escape and intracellular delivery via bioorthogonal luminescent reaction
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intracellular delivery of membraneimpermeable biomacromolecules is essential for a broad spectrum of life sciences ranging from fundamental biological studies to applied biomedical and pharmaceutical sciences despite the great efforts in developing new intracellular delivery nanocarriers in the recent 20 years simple highthroughput and accurate intracellular delivery quantification in live cells is still technically challenging in biolure i propose an unconventional approach to quantify intracellular delivery and endosomal escape by a bioorthogonal luminescent reaction in live cells instead of a bulky fluorophore i will label the molecule of interest moi to be delivered with a single amino acid tag which causes minimal changes in mois physicochemical properties and functions the tag will generate luciferase substrate inside live cells upon successful translocation into the cytoplasm by bioorthogonal reactions with chemoselectivity rapid kinetics biocompatibility and high efficiency the quantification strategy will initially be applied to the intracellular delivery of proteins via physical membrane disruption and validated by complementary methods it will then be expanded to nanocarriermediated endosomal escape with different mois including therapeutic sirnas the successful endosomal escape quantification will allow further nanoparticle screening for sirna deliveryi envision that biolure will lead to a paradigm shift in the intracellular delivery field facilitating the transformation from qualitative routine fluorescence imaging to highthroughput realtime quantification the high sensitivity and low background make it an appealing tool for biologists to study endosomal escape and for material scientists to develop potent nextgeneration nonviral intracellular nanocarriers eventually it will facilitate the design and screening of endosomal escape carriers and future nanomedicine formulations
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federate learning and multiparty computation techniques for prostate cancer
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the flute project will advance and scale up datadriven healthcare by developing novel methods for privacypreserving crossborder utilization of data hubs advanced research will be performed to push the performance envelope of secure multiparty computation in federated learning including the associated ai models and secure execution environments the technical innovations will be integrated in a privacyenforcing platform that will provide innovators with a provenly secure environment for federated healthcare ai solution development testing and deployment including the integration of real world health data from the data hubs and the generation and utilization of synthetic data to maximize the impact adoption and replicability of the results the project will contribute to the global hl7 fhir standard development and create novel guidelines for gdprcompliant crossborder federated learning in healthcare to demonstrate the practical use and impact of the results the project will integrate the flute platform with health data hubs located in three different countries use their data to develop a novel federated ai toolset for diagnosis of clinically significant prostate cancer and perform a multinational clinical validation of its efficacy which will help to improve predictions of aggressive prostate cancer while avoiding unnecessary biopsies thus improving the welfare of patients and significantly reducing the associated costs team the 11strong consortium will include three clinical data partners from three different countries three technology smes three technology research partners a legalethics partner and a standards organizationcollaboration in accordance with the priorities set by the european commission the project will target collaboration crossfertilization and synergies with related national and international european projects
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correspondence through millions bodies a largescale functional and implicit datadriven method for 3d humans matching
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interest in virtual humans is growing fast in public opinion and in several scientific and economic fields from entertainment to medicine from social sciences to ergonomics the market of virtual avatars has a value estimated around usd 10 billion and is expected to reach more than usd 520 billion in 2030 to investigate learn from and represent fairly the wide variety of human experiences tools to establish analogies or namely correspondence between them are required computer vision and graphics studied the problem intensely but so far no method has affirmed itself as a robust and flexible standard this ambitious action aims to fill this gap starting from three observations 1 few methods rely on implicit representations despite their flexibility and resilience 2 especially wellstudied theoretical methods capable of strong regularizations have never been applied to these representations 3 no method takes full advantage of largescale datasets this action will combine these aspects following a roadmap with three major scientific objectivesa collecting dataset of 10 million bodies with different properties encoded as implicit representation equipped with a groundtruth correspondenceb developing a novel datadriven framework based on functional maps theory for implicit representationsc deploying a largescale neural network for 3d human correspondence beneficiary of the previous bullets usable in realworld scenariosthis msca will produce substantial scientific economic and social impacts in this strategic field thanks to the interdisciplinary union of mathematical tools for functional analysis the latest advances in deep learning and domain knowledge of human bodies this action will carry an intense outreach to a broad audience informing on bodies digitalization process and the importance of fair representation of the human experience in this fastchanging technology
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reinventing multiterminal coding for intelligent machines
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advancements in sensors and deep learning have elevated the perception capacity of machines bringing midlevel autonomy within reach however the abundance of highdimensional data including video and dynamic point cloud streams strains current storage and communication technologies to their limits and curtails the ability of machines to collaboratively perceive the environment a critical factor for achieving safety and the ambitious goal of highlevel autonomy stateoftheart cooperative perception methods are based purely on a datadriven approach requiring massive training data and computational resources and lacking interpretability explainability and a solid theoretical foundationthis proposal puts forth a groundbreaking multiterminal coding paradigm for intelligent machines enabling data compression and communication systems that break the current limits of the predictive coding archetype it builds a unique concept that unifies traditional distributed source coding and signal processing domain knowledge with modern deep learning first it leverages machine learning to solve longstanding problems in multiterminal coding theory and devise code constructions achieving the fundamental limits thereby establishing a theoretical framework that defines the amount of information required to be sent per agent to solve the cooperative perception task second it leverages domain knowledge to drive the design of interpretable and data and parameterefficient machine learning models for cooperative perception third it reinforces this interplay by pioneering explanations that enforce and assess the interpretability of the designed models ionian will have a profound impact on the way intelligent machines including ground and aerial vehicles and mobile robots compress and communicate multisensory data to collaboratively perceive the environment for autonomous safe navigation ultimately leading to trustworthy operation and acceptance of such systems
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nonanimal platform for nanoparticlebased delivery across the bloodbrain barrier interface with vehicle evolution
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the bloodbrain barrier bbb is a major obstacle in treating diseases of the central nervous system cns such as parkinsons alzheimers schizophrenia and brain cancer affecting 180 million europeans with less than 5 of current candidate drugs effectively reaching the brain nap4dive strives to revolutionize the traditionally expensive and inefficient drug development for these diseases by establishing advanced nonanimal alternatives for testing and predicting nanoparticle npbased drug delivery across the human bbb this approach aligns with eu and global initiatives to reduce animal testing and advance humanbased biomedical research models the project will develop two complementary nonanimal tools a highthroughput bbbonchip and an in silico model based on machinelearning np design simulator a digital repository of optimized nanoparticle designs np design library will be created to gather publicly available and newly obtained np characterisation data specialised for bbb delivery the design simulator screens thousands of np designs to recommend the most promising ones which will be tested in vitro on the microfluidic bbbonchip with realtime measurement of barrier integrity the accuracy and physiological relevance of both tools will be validated by the pharmaceutical partner through comparison with clinical and preclinical data nap4dive tools will reduce animal use in cns drug development by up to 95 while saving 30 of costs by identifying nanoparticles for crossbbb drug delivery and offering avenues for new effective treatment options nap4dive addresses one of the most pressing healthcare challenges of the century a comprehensive hta will demonstrate market readiness and costeffectiveness of the tools an ethical assessment will analyse harm reduction and engagement with regulators and policy makers will promote nonanimal alternatives in preclinical testing on a larger scale
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humanguided collaborative multiobjective design of explainable fair and privacypreserving ai for digital health
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artificial intelligence ai is one of the most significant pillars for the digital transformation of modern healthcare systems which will leverage the growing volume of realworld data collected through wearables and sensors and consider multitude of complex interactions between diseases and individualpopulation while aienabled digital health services and products are rapidly expanding in volume and variety most of the ai innovations remain in the form of proofofconcept there is a continuous debate regarding whether ai is worthy of trust the eu ai hleg has defined that trustworthy ai systems should be lawful ethical and robust to translate it into actionable practices provision of explainability fairness and privacy is crucial a considerable volume of research has been conducted in the areas of explainable ai fair ai and privacypreserving ai however the current research efforts to tackle the three challenges are fragmented and have culminated in a variety of solutions with heterogeneous noninteroperable or even conflicting capabilities the ambitious vision of harmonicai is to build a humanmachine collaborative multiobjective design framework to foster coherently explainable fair and privacypreserving ai for digital health harmonicai draws together proven experts in ai health care iot data science privacy cyber security software engineering hci and industrial design with an underlying common aim to develop concrete technical and operational guidelines for ai practitioners to design humancentered domainspecific requirementoriented trustworthy ai solutions accelerating the scalable deployment of aipowered digital health services and offering assurance to the public that ai in digital health is being developed and used in an ethical and trustworthy manner
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towards h2ydrogen integrated economies in northern italy
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th2icino towards h2ydrogen integrated economies in northern italy supports the deployment of micro hydrogen economies for the eu by developing and demonstrating a full ecosystem integrated by 6 replicable use cases linked to the steps of the hydrogen value chain the results will validate a master planning tool mpt which replicability will be then tested the demonstration of the hydrogen valley will work on the four pillars of the hydrogen value chain i hydrogen production ii hydrogen storage iii hydrogen distribution and iv hydrogen consumption and will send the initial status of th2icino in order to enable replication and expansion a first stage will include modelling simulation and scenarization from electrolysis plant to enduser in order to evaluate different scenarios and optimize them taking into consideration the technological constraints once the optimal cases are defined an implementation phase will bring to reallife the innovative concept of the ecosystem tangible results to feed the mpt
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connecting healthtech innovation ecosystems for usercentred and businessdriven entrepreneurial education propelling nextgeneration digital health solutions
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rising costs resource pressures and an increase in chronic diseases together with the challenges posed by an ageing population have exerted significant pressure on europe to improve its healthcare and put forward healthrelated technological advances while much has been done inside healthcare institutions hospitals and clinics to stimulate innovation far less has been done outside the traditional healthcare frameworks to foster the development of innovative health solutions in this context less conventional players like educational establishments and training providers have proven to play an increasingly important role in developing an entrepreneurial spirit and driving innovation nevertheless the typical science education curriculum including the medical curriculum does not integrate any instruction on innovation or entrepreneurship which leaves a gap hence there is a strong need for education offers that can equip future health innovators with particular mind and skillsets and with the capacity to shape tomorrows healthcare to respond to the unmet need several health care innovation and entrepreneurship education and training offers with novel reallife approaches involving ecosystem members have emerged in the past years both in eg in denmark and outside europe in order to close the innovation gap across europe it is critical to foster the best practices and innovation resource flows between ecosystems at different development levels healtheconnect will strengthen the cooperation between two innovation ecosystems the healthtech innovation ecosystem of the lisbon region pt and the one of hovedstaden dk to support the rise and growth of nextgeneration healthtech companies through a codesigned usercentered and entrepreneurialdriven healthtech innovation and entrepreneurship educational offer launched in lisbon capitalising on best practises and platforms to sustain collaboration and resource flows between ecosystem members
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altered brainperiphery crosstalk as a key pathomechanism for highrisk phenotypes in humans
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diabetes is a leading cause for morbidity and mortality worldwide in our fight against the diabetes pandemic my team and i recently identified subgroups of humans that are predictive for future lifethreatening complications even before diabetes onset classification into these new risk groups is currently purely based on extensive phenotyping yet the underlying mechanisms are unclear of note phenotypes of very highrisk persons are highly reminiscent of those from subjects with altered peripherybrain communication i will combine groundbreaking experimental research in humans with latest data analysis approaches to delineate the causal relationship between altered brainperiphery communication and very highrisk phenotypesthe 1st aim will reveal disturbances in the brainperiphery communication in highrisk persons i will identify differences in the transduction of neuronal signals to the target organs discover regulators from the brain to the periphery and elucidate the regulation of underlying pathways the 2nd aim will clarify signalling from the periphery to the brain i will unravel the dynamic interaction between insulin and gutderived hormones on the brain identify signalling patterns that inform the brain about food intake and determine disturbances thereof in highrisk persons and i will noninvasively characterize postprandial molecular responses in neurons the 3rd aim develops a novel noninvasive approach to identify highrisk persons by their altered brainperiphery communication it will apply the abovegenerated knowledge to develop an algorithmbased integration of health data ultimately my project will innovatively define the impact of altered brainperiphery crosstalk in the development of clinically relevant highrisk groups it will set ground for novel approaches that optimize prevention and treatment of major complications and thereby improve future health way beyond what is achieved by current approaches
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biopharmaceuticals purification by continuous membraneassisted crystallization achieving lower cost and intensified processes
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with the growing global demand for biological medicines to address new therapeutic areas the biopure project will deliver a step change in monoclonal antibodies mabs purification through the implementation of radically new and disruptive technology to recover mabsproducts in the solidstate directly from cellfree culture fluids biopure promises to lower manufacturing and purchase of equipment costs with a smaller footprint it simplifies logistic chains and enhances environmental sustainability by avoiding extensive use of chemicals compared to the standard chromatographybased platforms it opens the doors to new possibilities and biomedicines so far too challenging economically or technologically as end result the citizens will have access to a more affordable and diverse selection of new generation biomedicines the proposed membranebased technology has already been proved at the laboratory scale trl4 as a cheaper and easily scalable alternative to protein a chromatography for mab purification the next step is to demonstrate the generalized efficiency of the technology and scale it up to trl6 through the design of a fully automatized prototype that will be operated continuously and capable of compliance with quality and regulations for biopharmaceutical productions in addition to technological development the new biopure technology will be validated with real market players leading to verifying the planned business model the ipr management plan and the associated financial planning included in the gotomarket strategy by achieving the main objectives of biopure it is expected that the adoption of membraneassisted method for mabproducts purification will provide a breakthrough advancement in terms of productivity efficiency via continuous manufacturing and cost reduction via process intensification
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relativistic jets in the multimessenger era
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the birth of multimessenger astronomy is unfolding in front of our eyes largely thanks to incredible observational developments the new observations challenge theory on numerous frontiers and my goal is to address some of those and to open others relativistic jets are the classical multimessenger sources typically dominating the observed signature of the objects that launch them relativistic jets even have their own gravitational waves signature jetgw that arises from the jet acceleration this signal largely ignored so far is a memory type wave that enable us to see directly the jet launching process and is probably the only way to do so detection of jetgws is extremely challenging and they may be easily missed if they are not looked for in this program i aim to achieve the understanding of these signals essential for their detection in addition i propose to explore observational implications of relativistic jets as they are manifested in binary neutron star mergers bns gammaray bursts grbs and a subpopulation of supernovae sne that harbor hidden jets and tidal disruption events tdes i will study the basic physics involved carry out large scale simulations and probe new observational results i will focus on new physics for example photodissociation of heavy nuclei during jet propagation within bns ejecta that hasnt been considered so far powerful jets appears in some tdes but not in others this makes tdes natural laboratories to pursue the major open question under which conditions are powerful jets launched although bns grbs sne and tdes appear to be very different their jets have a lot in common understanding them requires analysis of the same basic physics and application of similar numerical tools this joint study that breaks artificial conceptual barriers will be highly beneficial and fruitful
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the epistemology of costly communication offline and online
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in our digital era characterised by easy access to both information and misinformation understanding the mechanisms that encourage truthful communication is more crucial than ever despite the social and ethical importance of these issues however we lack a unified framework to systematically investigate the social incentives that motivate speakers to communicate truthfully costx will inaugurate a novel interdisciplinary empiricallyminded approach to studying communicative norms the projects overarching goal is to develop a new methodology grounded in costly signalling theory to study how norms and reputation underlie truthful communication offline and online adopting this new lens costx will radically change our understanding of a diversity of phenomena relating to truthfulness i the nature and epistemic function of communicative norms ii deniability and indirectness in speech iii testimonial transmission of knowledge and iv online communication it will inaugurate a new field of study digital infrastructure epistemology which investigates how misinformation spreads by attending to how online platforms alter the reputational infrastructure that motivates speakers to be truthfulmethodologically costx will bring rigorous analytic thought into dialogue with empirical research theoretical assumptions will be tested empirically and theorybuilding will profit from interdisciplinary crosspollination from linguistics biology game theory epistemology and psychology it will be of high scientific value to all disciplines investigating or building on human communication and its norms its findings on online communications will have practical uses establishing philosophical foundations to better understand and tackle the spread of fake news thus bolstering support for democratic institutions which rely on a healthy information environment to function properly
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stardance the noncanonical evolution of stars in clusters
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thanks to their ubiquity brightness and the fact that they are made of stars with similar properties star clusters have been used as astrophysical laboratories or test particles in an impressive range of research domains however we still do not understand fundamental details of their formation and evolution in spite of recent technological progress a list of unsolved problems and apparently isolated mysteries has been accumulating over time some standing since decadesamong them the existence of multiple stellar populations in globular clusters with different chemistry has challenged generations of researchers they are not the result of classical galactic chemical evolution mostly mediated by supernovae and they jeopardize the use of clusters as simple stellar population templates for extragalactic studiesgiven the mounting problems faced by the most favored scenarios to explain multiple populations i think it is now time to revisit the foundations of our current thinking new results by my team and by others show that i the peculiarities in the chemistry of multiple populations are not limited to the oldest globular clusters ii they can be transient in the evolution of individual cluster stars and most importantly iii binary interactions and fast stellar rotation cannot be neglected in the study of star clusters and do have the capability to produce the observed chemistrywith stardance i will test a very different scenario based on a new hypothesis that multiple stellar populations and five other noncanonical stellar populations extreme horizontal branch stars and hot subdwarfs extended main sequence turnoffs red stragglers and subsubgiants lithium rich stars and blue stragglers are caused by the interplay between stellar rotation and binary interactions that are greatly enhanced in the special environment of star cluster with spectacular results
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soteriological itineraries in the ancient mediterranean world
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mappingsalvation aims at establishing a novel methodology for the study of salvation experiences and theories structured around a newly developed epistemic model that allows for a thorough investigation of salvation itineraries across multiple cultural contexts the geographicalhistorical framework of reference for this research is the mediterranean basin in the early roman imperial age a world animated by a strong pervasive desire for salvation which permeated most areas of human experience philosophical reflection religious cults and beliefs political life and ideology ritual and divinatory practicethis project relies on the groundbreaking hypothesis that only by conceiving the ancient mediterranean world as a wide intricatenetwork of salvation itineraries can we fully exploit the heuristic potential of the category of salvation understand the profoundphilosophicalreligious dynamics of the first centuries ad and even discover unexpected similarities between this age and ourcontemporary world where the needs to save human lives animal species and our planet are all the more urgent and intenseby analysing the greek and latin works of two apparently distant thinkers seneca the younger and clement of alexandria mappingsalvation will attain a twofold aim first to validate empirically a new analytical model and taxonomical system for the examination and categorisation of salvation itineraries second to inaugurate a wideranging discussion around the concept of salvation and a cooperation among different scholars and fields of expertise that have worked separately until today if successful mappingsalvation will revolutionise the way in which we look at salvation in antiquity and beyond and will establish a shared conceptual apparatus and common epistemic standards for its study
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optimizing production and logistic resources in the timecritical bio production industries in europe
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the clarus project aims to connect the sustainable paradigm in the food industry and aibased applications with the goal of developing a platform with high communications and processing capabilities as well as the use of standardized open protocols and data models that will allow resource consumption assessment and traceability for food industry processesthe project will be submitted under the call hecl4digitalemerging0109 ai data and robotics for the green deal and will target the nonrobotic outcome currently two pilots have been selected for validating the clarus solution the first pilot focuses on the production of the frozen food where energy and water consumption can be reduced using ai and data technologies the other pilot focuses on the meat byproduct production where the aim is to reduce the energy and maintain the quality of the products by optimizing the logistics of the byproducts arrival clarus ambitions include not only contributing to resource and logistic optimization methods through the two pilot solutions but also making a more general contribution through the creation of a green deal index gdi
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production of an innovative millifluidic device for testing of new probiotics
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over the last decades the gut intestinal microflora and other microbial communities present in our body raised a strong interest in the health research domain as it was discovered their possible relation to the pathophysiology of major organs and systems gut epithelial cells together with our resident microbiota are involved in the modulation of the host immune system and represent the first line of adsorption of drugs and nutraceuticals in parallel to microbiota studies a great effort has been devoted to assess the role of the probiotics live microorganisms that administered in adequate amounts are able to confer a benefit to the host health probiotics are currently widely used in the preventiontreatment of many diseases one critical point that is still an issue in the characterisation of new potential probiotics is the difficulty in mimicking with high reliability the gut microenvironment condition using animal models or the current in vitro tools poorly representative of the real in vivo situation this gap motivates the need for the development of alternative research tools such as the fluidic devices to study the mechanisms at play in human gut microenvironment and contribute to the success rate of expensive risky and timeconsuming preclinical and clinical trials in this frame our prometeo project aims to perform the technical and commercial feasibility of an integrated probioticgut epitheliumimmune system millifluidic platform based on a patented organonachip technological device providing the basis for a new generation of innovative solutions for probioticsdrug development prometeo will be run by a consortium between politecnico di milano and aatadvanced analytical technologies a forefront sme specialized in promoting innovation in the probiotic sector thus combining a solid technological expertise and an indepth knowledge of the market
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sparc sustainable parasite control in grazing ruminants
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ruminant farming is critically important in maintaining the viability of rural communities and ensuring food security because grazing ruminants are permanently exposed to helminth parasites efficient worm control is a requirement to guarantee their health welfare and productivity worm control is largely based on preventive use of anthelmintic drugs but excessive use of anthelmintics has led to anthelmintic resistance which has become a global threat for effective parasite control to mitigate anthelmintic resistance in ruminants sustainable worm control swc strategies should be adoptedthe sparc community of practice of farmers farm advisors and veterinarians will identify needs practices barriers and drivers for adoption of swc practices develop a list of good practices for swc in different production systems and regions and demonstrate them on pilot farms national and international stakeholder networks will share swc practices among farmers across borders and production systems beef and dairy cattle meet and milk sheep and goats dissemination of experiences and results will be facilitated by a knowledge exchange platform on the sparc website hosting testimonies case studies videos practice abstracts and decision support tools available in local languages sparc activities and results will be communicated on social media and in professional journals overall sparc will initiate a lasting europeanwide multiactor community that develops solutions together to curb anthelmintic resistance aiding in the green transition of european agriculture
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understanding the new oxidative paradigm of biomass waste upcycling
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as the eu is committed to becoming the worlds first climateneutral continent fossil fuels need to be replaced by sustainable alternatives a potential alternative is the upcycling of lignocellulosic biomass to biofuels however the costefficient generation of biofuel from cellulose is considerably hindered by the recalcitrance of the cellulose biopolymer in 2010 the discovery of a new family of copperdependent metalloenzymes called lytic polysaccharide monooxygenases lpmos spurred great hopes as lpmos were shown to significantly boost the degradation of cellulose and other polysaccharidestoday eight families of lpmos have been classified with remarkably diverse substrate specificities and regioselectivities furthermore the metal active sites are in rather different surroundings despite combined efforts from experimental and theoretical sides the reaction mechanism of lpmos has remained elusive the here proposed lyticpol project suggests that previous theoretical studies lacked general conclusions because they i considered too few lpmo families and ii employed insufficient theoretical methods for the enzyme environmentthe lyticpol project aims at elucidating the reaction mechanism of lpmos by using a novel theoretical method on a large set of representative lpmo structures from knowing the mechanism the reaction conditions of lpmos can be finetuned and the full industrial potential can be reached this is expected to have substantial economic and social impact hence the results of the lyticpol project will be communicated not only to scientific experts but also to the general public the project will be carried out by dr erna k wieduwilt ekw under the supervision of prof erik d hedegrd at the university of southern denmark the project itself and the training of ekw will contribute decisively to her career goal of becoming an innovative and independent researcher in the field of theoretical bioinorganic chemistry
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curing ovarian cancer through autoantibodybased therapy
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ovarian cancer oc is a malignant tumor with poor prognosis and limited treatment options responsible for 44 of cancerrelated mortality in women there is an urgent need for innovative therapeutic approaches for oc antibody drug conjugates adcs represent one of the most promising therapeutic approaches but their efficacy has been hindered by identification of suitable tumorassociated antigens for example adcs targeting muc16 the best diagnostic marker for oc have thus far failed in clinical trials due to shedding of muc16 from the tumor our breakthrough lies in the identification and characterization of a muc16specific autoantibody clone 2b5 which specifically targets the nonshed and highly conserved epitope of muc16 that stays associated with the tumor this consequently dramatically increases the efficacy of the cytotoxic payload delivery to the tumor and overcomes limitations of similar adcs that have failed in the past by directly and selectively targeting muc16 on oc while sparing healthy tissues our adc has the potential to revolutionize oc therapy by finally offering a precise and effective adc cancer treatment thus for this poc we aim to demonstrate the effectivity of our 2b5based adc as a leading candidate for oc therapy in humans in order to increase its therapeutic and commercial potential the 2b5based adc will be developed further to identify the most suitable payload as well as to validate its tumor killing efficacy in preclinical animal models which will be developed in frame of this project by the end of this poc we aim to be ready to develop our 2b5adc to human grade towards phase 1 clinical trials simultaneously we will define the innovation commercial feasibility and business model and will validate the business opportunities and gotomarket strategies with relevant stakeholders furthermore we have already initiated the process of patenting our innovation and aim to finalize it during the poc
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investigating the effect of composite microstructure on wave propagation characteristics and development of an ultrasonicdatadriven computational framework for composites damage mode identification
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the eu is a world leader in the transport industry especially aviation it is predicted that the number of flights in europe will increase to 13 million in 2028 26 times more than those in 2020 this remarkable number of flights will place airworthiness at the heart of technology development which makes regular inspection timely diagnosis of technical problems and optimising design and construction of aircraft components of paramount importance superior mechanical properties especially a high strengthtoweight ratio make composites an ideal candidate for the construction of aircraft parts however detection and evaluation to maintain composite structural integrity are particularly challenging since they are inhomogeneous and anisotropic although ultrasonic guided waves ugws have exhibited strong potential for detecting damage signatures in composites nucleation of defects and damage propagation occurring within numerous locations at several length scales make it difficult to track all the damage sites and mechanisms which is vital for improving composites design and production thus understanding ugw interaction with complex anisotropic structures of composites that can be accessed considering composite microstructure is a fundamental issue that remains unresolved microsonic will bring a fellow with expertise in micromechanics and damage modelling together with the host institution carrying leading knowhow in ugw interaction modelling to investigate the effect of composite microstructure ie fiber size volume fraction and distribution and microdamage on wave propagation and establish the next generation of ultrasonic usdatadriven computational frameworks developed based on the micromechanics outputs for composites damage mode identification microsonic will provide safer flights by establishing a robust tool for online monitoring of aircrafts structural health state and boost europe to the forefront of the inspection and maintenance market
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