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slaves of religion paternalism and resistance brazil
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slavesreligion is an interdisciplinary proposal aimed at understanding the process of implementation exploitation and perpetuation of slavery in the properties of the lusobrazilian benedictine congregation between 1750 and 1871 highlighting issues related to gender race and slavery in the atlantic world it also intends to analyse the resistance strategies built by enslaved men and women against the disciplinary and moralising measures of the order of saint benedict the project aims to demonstrate that this congregation played an important role in the construction of modern slavery transforming it into one of the richest and most powerful slave orders in brazil the benedictines built efficient and durable strategies for managing slaves through measures designed to control female behaviour access to freedom and reproduction despite the importance of this congregation in the construction of modern slavery few historians have analysed its peculiarities there are indications that this religious order encouraged its slaves to own slaves moreover there is also evidence that they encouraged enslaved women to reproduce in exchange for benefits especially freedom besides there are suggestions that they allowed slaves to accumulate patrimony and pass it on by inheritance to their heirs the results of this research will be disseminated through various means such as social media digital platforms and seminars among others when concluded the research will render three scientific articles on the peculiar slave management of the benedictines and the resistance strategies of the enslaved population with a special focus on slave women
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method for integrated alloptical biological analysis at scale
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the advent of lightemitting sensors and lightdriven actuators has profoundly transformed the fields of biology and medical science over the past three decades these innovations enable the manipulation and monitoring of various physiological processes using light with remarkable precision in both time and space applications include the study of signaling and cell trafficking in healthy and malignant tissues the unraveling of causal relationships within neural networks or the assessing the effects of pharmaceutical compounds to fully harness the potential of these socalled optogenetic technologies there is a pressing need to create integrated optical systems offering both 3d imaging and precise lighttargeting of specific regions at scale within the framework of the erc we have successfully engineered a unique system designed for the optogenetic probing of small vertebrate brains zebrafish larvae at cellular resolution our proposal expands upon this earlier achievement by evolving it into a versatile alloptical platform tailored for biologists and biomedical laboratories this platform will seamlessly integrate cuttingedge optical systems with automated data analysis through artificial intelligence ai techniques anticipating a vast array of applications we envision that this platform will prove invaluable eg in the realms of neuroscience developmental biology and cancer research its multifaceted capabilities will empower researchers to unlock new insights and accelerate advancements in these critical scientific domains
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preclinical study continued technology development health economic analysis for navari surgical ab
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cancer is one of our times most threatening diseases killing more than 10 million people each year approximately 60 of all cancer patients will need some type of surgery where minimal invasive surgery is commonly known as the best type of procedure from the patients perspective where recovery time and infections can be kept to a minimumdespite proven benefits from a patients perspective the utilization of minimal invasive cancer surgery remains relatively low limited visualization with large challenges in identifying the cancer tumors position are a strongly contributing factor the limited view from the surgical camera makes it challenging for the surgeon to navigate along the surgery procedure not to mention removing the tumor with precise marginsnavari aims to revolutionize todays minimal invasive cancer surgery by developing a technology increasing the visualization aspect during this type of procedure by utilizing augmented reality navaris innovation can present the surgeon with an arprojection showing the cancer tumor and its exact position inside the organ the projection of the cancer tumor is shown as an integrated part of the video feed from the surgical camera enabling livestreamed navigation assistance along the full procedure in short terms our innovation enables surgeons to locate and remove the tumor in the safest and most precise way possible in this project we aim to design and perform a preclinical study realizing our next value enhancing milestone giving us the validation needed for the innovation to enter future clinical studies with the data given from the preclinical study the business model could be validated further where a health economic analysis could be performed measuring the social sustainability impact of our innovation the outcomes from the study would enable further product optimization from a technical perspective as well as strengthening our communication towards investors
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hydrogen industrial inland valley
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the hi2 valley project will establish a largescale renewable hydrogen h2 economy in the austrian industrial regions of upper austria styria and carinthia directly contributing to the goals outlined in the european green deal repower eu and hydrogen strategy the project will achieve this by decarbonising key sectors through h2 drastically reducing emissions in the steel chemical and cement industries as well as in energy and mobility via displacement of fossil fuels including reducing the reliance on natural gas which austria overwhelmingly imports from russia with 13000 tons of green hydrogen being needed in the regions by 2028 over 10000 tpy of green hydrogen will be produced within this hi2 valley by introducing strategically placed decentralised h2 production facilities the project will strengthen the countrys energy resilience and flexibility and create a robust domestic market for green h2 the hi2 valley will play a crucial role in bridging the gap between southern and eastern european hydrogen supply corridors being embedded on the european hydrogen backbone and tent network and future pipeline connections pcis with southern europe and north africa the hi2 valley will seamlessly connect austrias multiuser h2 ecosystem with neighbouring countries like germany italy and slovakia fostering a truly interconnected central european hydrogen network this role model helps to secure industrial jobs and through standardisation and integration brings costs of hydrogen down creating a green industrial future for europe going beyond its immediate neighbours the hi2 valley will also foster knowledge sharing and wider adoption of green hydrogen through the active collaboration with five other emerging hydrogen valleys in eastern europe in poland romania hungary latvia and the czech republic
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towards turbine blade production with zero waste
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10000 wind turbine blades wtbs were installed in europe in 2019 and the largest are 100 m long yet the manufacturing methods have not changed significantly since the 1970s with little or no ndt or inline control leading to high defect repair and scrap rates turb0 will reduce defects and improve repair strategies in wtb composites and coatingsimproved composite production processes by using the latest simulation techniques to avoid defect formation and understand how defects affect structural integrityinline ndt combining three cuttingedge ndt technologies dielectric wireless sensorless for the first large scale inline in situ composite production monitoringsubsurface wtb coating inspection currently coatings only undergo visual surface inspection or destructive testing turb0 will combine ultrasound and midir oct for the most detailed coating assessment ever performeddigital twin and data warehouse production equipment monitoring and inline ndt data will be combined to establish a digital twin for realtime analysis of production this has never been attempted for a largescale composite part it will populate a data warehouse accessible from multiple production sitesinline system control using the digital twin a mlbased algorithm will provide closedloop process control to minimise defect formation and waste and optimise process efficiencyautomated repair strategy the digital twin enables a ml analysis of defect severity in composites with automated strategies to reduce repairs by 90 and increase recycling of offcutsfullscale demo a demo on a full size 80 m wtb section will be performed at the sgre factory in aalborgquantified sustainability improvements including life cycle analysis lca social lca and circular economy assessments to quantify environmental and socioeconomic benefitsdissemination and exploitation activity includes a powerful advisory board training standards and business plan
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revolutionary accuracy in waveguide and photoacousticenabled atmospheric sensors raven
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anthropogenic greenhouse gas ghg emissions and deteriorating air quality are driving climate change and severely impacting human and ecosystem health respectively to combat these issues new and more stringent green regulations are being implemented globally which existing air monitoring systems are not well equipped to handle currently available commercial sensors are expensive bulky and frequently require shelter and power from the mains field performance also often falls lower than required due to high signal noise and drift consequently there is a need for new air pollution and ghg monitoring systems that offer improved sensitivity precision and accuracy while also being inexpensive compact and energy efficient raven will develop the next generation of gas sensing systems consisting of two miniaturised gas sensors implementing cuttingedge pic technology one in the visswir range and one in the mir range these sensors will work in tandem across a broad wavelength range 6003000 nm to measure concentrations of multiple pollutants and ghgs including co2 co o3 ch4 n2o ch3oh nh3 no2 in 125 ppb lod range the sensors will leverage cuttingedge science including developing a highpower compact dualsupercontinuum source on a chip and onchip data analysis using a quantuminspired approach for improved lod and selectivity of gases and to satisfy the performance power consumption size and cost requirements of end users raven will offer an unparalleled highperformance multisensing solution that can be packaged into a single nearuniversally applicable miniaturised system the implementation of raven technology will provide europe with the necessary resources to ensure compliance with the eu green deal and enhance the photonic technology capabilities of the eu
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cocreating inclusive intersectional democratic spaces across europe
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the objective of this project is to rekindle trust in democracy and to reinvigorate engagement with democratic institutions and values in europe we plan to achieve this by cocreating solutions to the crisis of democracy by designing and implementing strategies which counter opposition to equality and democracy and by supporting citizens and activists working in this field ccindle works directly with feminist grassroots activists and institutional actors feminist and prodemocratic media young europeans philanthropic organizations thinktanks and gender professionals we cocreate knowledge on i antigender campaigns and how they challenge democracy particularly through political violence and alternative knowledge production ii futures of society envisioned in feminist theories and how they relate to democracy in europe with respect to intersectional justice inclusion and participation iii feminist movement and institutional responses to antigender and other antidemocratic forces we focus on seven european countries with different social and political backgrounds and the eu level this knowledge allows us to better understand everyday practices of democracy and how the current backlash resonates with broader exclusionary tendencies and fundamental problems of the western democracy model we assume that the problem is not antigender movements alone but also the roots they have in the exclusionary features of contemporary european democracies the way in which they are normatively designed and function ccindle provides for concrete approaches and tools to more effectively fight antigender and other antidemocratic forces support the quality of democracy and make democracy across europe more resilient and inclusive we put these approaches and tools into practice through cocreating actions including student juries a network of intersectional feminist media across europe gender cafs blogs and other networkingdissemination activities
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bacteriophages as vehicles for antimicrobial resistance determinants do they represent an environmental risk
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although antibiotic resistance is a major and growing public health concern surveillance for the expansion of this phenomenon in environmental settings has not been fully explored however recent studies suggest that antibiotic resistance found in clinical settings may emerge from environmental sources in fact the environment is continually exposed to a wide variety of antimicrobials and their metabolites through wastewater treatment plant discharges agricultural runoff and animal feeding operations which may contribute to the emergence and spread of antibiotic resistance it is therefore necessary to understand the mechanisms and factors that promote antibiotic resistance the phaster project aims at exploring the presence diversity and abundance of bacteriophages in the environment particular points of interest will be the study of bacteriophages that lead to the mobilization of antibiotic resistance genes args and their interaction with antibiotic compounds even at extremely low concentrations similar to those found in some aquatic environments mesocosm experiments will also be conducted to examine how bacterial communities respond to the presence of bacteriophages harbouring args under stressful conditions such as exposure to antibiotics in order to reach these goals a combination of metagenomics and bioinformatics approaches will be used to investigate the sources of args their environmental distribution and how anthropogenic inputs affect their spread a better understanding of the mechanisms and factors that contribute to antibiotic resistance will permit the implementation of appropriate public health strategies policies and mitigation programs special attention will also be devoted to dissemination so that stakeholders and policy makers can benefit from phaster
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role of prenatal stressinduced fetal neuroimmune rewiring in susceptibility to develop pediatric eczema
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the prenatal period is a critical timeframe during which all the physiological systems of the body including immune and sensory systems develop their specific functions and adapt to possible incoming cues atopic dermatitis also known as eczema is the most common skin manifestation in infants and toddlers from 3 months to 2 years of age with a very early onset during the first years of life while genetic and immune factors play an important role recent epidemiological studies have listed prenatal stress as an important risk factor of allergic disorders and associated prolonged exposure to high emotional strain during pregnancy to an increase in the offspring susceptibility to develop eczema the proposed project aims to seek external factors that might influence the development of eczema in infants through the lenses of neuroimmunology we wish to use sophisticated mouse models single cell transcriptomics and wholetissue imaging approaches to evaluate how a relevant model of noninfectious prenatal stress can predispose offspring to develop eczematous lesions that resemble pediatric atopic dermatitis we will then explore if the observed phenotype could be driven by in utero dysregulations of myeloid cells in particular mast cells and peripheral sensory neurons development and subsequent formation of abnormal skin neuroimmune units in offspring to accomplish these goals we have proposed herein a body of work that is solidly based on preliminary data with four aims that will test innovative hypotheses by using informative transcriptomic approaches as well as a new multiplexed imaging system that we recently developed this work will thus address significant gaps in our knowledge about how prenatal adverse events could set the stage toward the development of classical features of pediatric eczema and most importantly should lead toward potential new therapeuticpreventive options for allergic disorders
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building a coordination hub to support the mission implementation in the atlantic and arctic basin
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bluemissionaa will be the coordination hub that will support the implementation of the eu mission restore our ocean and waters by 2030 in the atlantic and arctic basins it will focus on restoration of marine and coastal ecosystems and increased climate resilience bluemission aa will have a structuring effect to consolidate and mobilise a wide community of relevant stakeholders and eu citizens towards the achievement of mission objectives at basin level it will deliver an effective governance framework aligned with policies initiatives and actions at national regional and eu level wp1 build a wellcoordinated monitoring framework to assess the progress of the implementation on an ongoing basis wp2 provide a wide range catalogue of supporting services wp3 foster an attractive innovation ecosystem for ecological restoration wp4 and give the opportunity and empower eu citizens to engage in the preservation and restoration of oceans and waters through participative means wp5 six case studies will be selected across a range of representative restoration approaches to represent restoration approaches eg protection active restoration sustainable harvesting to represent existing and proven methodologies from recent and ongoing projects and networks the case studies will deliver guidelines and recommendations in respect of optimum governance approaches for delivering environmental protection and restoration in marine freshwater and transitional water systems and scalability for achieving mission objectives bluemissionaa will develop two regionspecific proposals towards an effective mission lighthouse governance one for the atlantic and one for the arctic
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interlayer exciton interactions and their manybody physics
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monolayer transition metal dichalcogenides tmds exhibit exceptional properties to study manybody physics with direct optical control through their tightlybound excitons and enhanced coulomb interactions even more versatile physics emerge in heterobilayers of tmds which host longlived dipolar interlayer excitons ixs with promising potential for quantum simulation experiments and realizing a plethora of correlated phases in recent years tmd heterobilayers have been at the center of manybody physics where effects such as the formation of a wigner crystal the demonstration of hubbard model quantum simulation and the realization of boseeinstein condensates are just a few examples however deterministic control of single ixs and therefore interactions among individual ixs has not been shown for msca project i propose to study manybody physics of ixs starting from the individual ix level and then progressing to small and well controlled ix populations to do so i will use nanoscale patterned graphene electrical gates to trap and manipulate them this topdown approach is scalable and flexible allowing for the creation of arbitrary trap potentials and geometries the scope of this twoyear project is to use this technique to fundamentally study the excitonexciton interactions that are at the basis of the exciting physics that arises from these new materials however the scientific potential of a method that can sitecontrol ixs does not end here this technique could form the foundation for quantumsimulation demonstration of hubbard model physics and exploring new quantum phases
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chiral phononics controlling electronic phases with phonon angular momentum
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this projects aims to establish a new paradigm in the ultrafast control of solids by using the angular momentum of chiral lattice vibrations chiral phonons to manipulate induce and switch electronic phasesthe properties of solids are fundamentally determined by the crystallattice geometry developments of ultrashort terahertz and midir pulses in the past decade have made it possible to dynamically modify the crystal structure by resonantly driving coherent phonons these phonons exchange energy and momentum with the electrons modifying interactions that are dependent on the distance between the atomschiral phonons in turn have mostly been regarded as a dissipation channel for electronic angular momentum and only recently been used for ultrafast control of solids following seminal theoretical predictions of me and my colleagues the reason for this is rooted in two challenges the lack of feasible protocols to coherently excite chiral phonons across the brillouin zone and the complexity of angular momentum coupling processes out of the equilibriumchiralphononics will address these challenges by bridging the gap between phonon angular momentum theory and ultrafast dynamical simulations my team and i will investigate how phonon angular momentum can be coherently generated coupled to electronic spin and orbital degrees of freedom that are connected to functional properties including topological and ferroic order we will combine microscopic modeling with firstprinciples calculations to create effective abinitio informed models that allow us to both predict novel fundamental coupling mechanisms as well as realize quantitative materials implementationsthis research will lead to new functionalities in solids and design principles for quantum materials out of the equilibrium pioneering the field of ultrafast chiral phononics will open an avenue towards technologies based on phonon angular momentum switching of electronic states
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tracking the north atlantic water circulation during the last glacial period using multiproxy approaches
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ocean circulation is a key regulator of climate that driven by both atmospheric and thermohaline processes the labrador sea holds a complex mixture of water masses and plays a crucial role in north atlantic deep water formation and the atlantic meridional overturning circulation and thus for global ocean circulation however the mechanisms of the labrador sea water formation and its interactions with upper north atlantic deep water remain largely unknown understanding the water formation of the labrador sea water and ocean circulation in the north atlantic region in historical time by using proxy reconstruction data is crucial for benchmarking and understanding the present and future variations using model simulations the purpose of this proposal is to provide information on the evolution of the north atlantic intermediate water formation and the impact of changes on ocean circulation in the labrador sea during several cold periods including the last glacial maximum understanding of north atlantic water inflow the labrador sea deep water ventilation conditions and formation respond to the fundamentally different glacial cold events by combining benthic foraminiferal morphology and geochemistry data and other existing proxies this project will discover the link between shell morphology and multiple stresses and quantitatively evaluate the impact of changes in the ocean circulation on marine ecosystems the project aims to apply a multiproxy approach including the application of foraminiferal morphology and geochemistry to reconstruct the seawater conditions i will generate new highresolution records of changes in subsurface to deepwater formation in the labrador sea region to evaluate the impact of changes in ocean circulation and to significantly improve the application of this multiproxy approach results from this project will also increase the data window of oceanic circulation for climate model validation
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electrical competitive propulsion
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faced with the increasing demands of satellite contractors in terms of costs and mission capabilities the eus space sector must be ready to react as quickly as possible to the needs related to the evolution of space infrastructures and markets to stand out from the competition at global level electric propulsion ep based on halleffect thruster het is strategic to foster the eus space sector competitiveness europe needs competitive ep systems or eps combination of a power processing unit ppu driving and delivering electrical power to a het the ppu has a strong impact on the eps cost and performances completed in 2021 the h2020 ganomic project demonstrated the feasibility of major disruptive technologies for the ppu a ppu based on these technologies will open the way to extend drastically the mission field capability and efficiency of eps pushing propulsion systems to an unprecedented level of competitiveness capability and efficiency to achieve these impacts ecopropu takes over from ganomic and will develop five key generic building blocks for the ppu which are crucial to unlock the target performances of the eps three functions of the ppu anode module digital processing module magnet power converter and two other building blocks on which the anode module rely dab digital controller and planar transformer ecopropu will also prepare and evaluate the het adaptation to high voltage operation brought by this innovative ppu by better understanding stability and magnetrelated phenomena and a complete operation mapping of a large domain thruster 27kw 250700v operating domain the impact of this project will be to give the consortium industry the capacity by 2025 to develop disruptive and economic ppu and versatile eps medium to high power class allowing to reach a european worldwide leadership in eps and offer to european space primes and agencies improved performances and cost reduction for their space missions
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strengthening the capacity for excellence of slovenian and croatian innovation ecosystems to support the digital and green transitions of maritime regions
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the main goal of inno2mare is to strengthen the capacity for excellence of western slovenian and adriatic croatian innovation ecosystems through a set of jointly designed and implemented actions that will support the digital and green transitions of the maritime and connected industries based on an indepth mapping of the ecosystems and needs gaps analysis the consortium will formulate a longterm ri strategy aligned with regional national and eu strategies as a visionary framework and a joint action investment plan with concrete steps for building coordinated resilient attractive and sustainable maritime innovation ecosystems to support the joint strategy and provide a model for the future collaborative ri of the ecosystems actors the project will implement three ri pilot projects that address some of the key challenges related to maritime education and training security safety in marine traffic as well as energy conversion and management systems efficiency these pilots will be the basis for further development scaleup and translation of the generated research results into innovative business opportunities through the coordinated mobilisation of public and private funding the consortium will also implement innovative programmes that will support the engagement of citizens in the innovation processes knowledge transfer for mutual learning entrepreneurship smart skills training and attraction of best talents involving more than 1000 participants across the quadruple helix in all the project activities the two ecosystems will strongly benefit from the sharing of best practices of the flemish ecosystem one of the most developed maritime innovation ecosystems globally the project will contribute to reducing the innovation divide in europe by systematically connecting the innovation actors within and between the ecosystems and creating synergies in ri investments planning and execution thus developing a true innovation culture
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advanced circuits for detection and control of diamond quantum sensors
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quantum sensors using nitrogenvacancy nv spin colour centres in diamond have made great strides from scientific curiosity towards practical applications first devices for example diamond scanning probe microscopes are on the market however large scale applications are limited by the availability of a compact hardware combined with the diamond quantum chip and their costeffectiveness acdcq tackles these challenges by creating a fully integrated system for control and readout of nv centres by making use of semiconductor technology the project builds upon a first demonstration of this integration oeaw infineon the device makes use of electrical readout of nv centres as pioneered by imec and developed by the applicants in previous eu projects further development of the integrated logic in acdcq will allow controlled excitation and spin manipulation devices the integration will lead to compact and costeffective realization while reaching stateoftheart performance comparable to devices constructed on an optical table the devices will be developed towards commercial applications in magnetometry including nondestructive evaluation kwanttek space magnetometry imec asi and remote monitoring thales the device performance will be calibrated in the precise eu metrology facilities ptb by bringing together pioneering academic research with cuttingedge semiconductor industrial processes and leading manufacturers acdcq will transform diamond sensors from laboratory experiments to prototypes developed to target commercialization
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a predictive coding perspective of brain dynamics the case of oscillatory travelling waves
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one of the most exciting yet puzzling questions in neuroscience is how the brain coordinates the activity between different areas integrating distinct representations into conscious percepts and thoughts for decades neuroscientists have investigated how the brain orchestrates diverse regions activity pointing at oscillations as one of the key mechanisms involved in such a process however previous research has mainly focused on the temporal aspect of oscillatory dynamics largely overlooking how oscillations propagate through the brain although rhythmic traveling waves have recently gained renewed interest their functional role and relation to cognitive functions remain largely unknown in this project i will address this fundamental question what is the role of oscillatory traveling waves in brain dynamics i plan to take on this challenge using a multiscale computational approach modeling neural dynamics within and between cortical regions as well as corticalthalamic interactions importantly the novelty of this approach consists in framing the model in the light of predictive coding principles to test the compelling yet striking hypothesis that traveling waves encode predictions and predictionerrors the results of the simulations will be compared against experimental recordings in human participants to validate and assess the models predictions lastly some implementations will turn into deep learning architectures to test their dynamics in visual tasks while improving current models of artificial vision all in all this proposal can significantly advance our understanding of the neurophysiological mechanisms involved in sensory and cognitive functions testing whether and how oscillatory traveling waves are a critical mechanism in neural dynamics and producing fundamental results in the scientific field and future technological applications
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ligninolytic enzymes keys to unlock the hidden potential of lignin
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context globally 5070 million tons of lignin a highly branched heteroaromatic polymer are discharged per year as a waste material from the paper and pulp industry despite being touted as the most abundant renewable source of different valueadded products on earth leaving 98 of lignin underutilized industries degrade only 2 of lignin and that also comes with environmentally hazardous thermochemical processesbackground recently the discovery of hemecontaining class ii fungal peroxidases viz lignin peroxidase lip manganese peroxidase mnp versatile peroxidase vp dyedecolorizing peroxidase dyp garnered a lot of attention due to their biodegradable ligninolysis however the industrial application of peroxidasebased lignin degradation still seems to be a farflung dream owing to low availability of peroxidases in sufficient amount enzyme instability in industrial effluent high enzyme cost and long process timesaims and objective i hypothesize that a cocktail of engineered stress tolerant active and stable peroxidases could lead to synergistic biodegradation of lignin to achieve this artificial intelligence ai tailored lip mnp vp and dyp will be cloned and expressed as inclusion bodies ibs in e coli using prof spadiuts expertise whereas mine will employ solubilization and refolding strategies to increase the overall yield of bioactive protein an ideal stoichiometric combination of engineered peroxidases will be standardized to withstand the harsh conditions of industrial effluent resulting in a sustainable and economic ligninolytic technologyconcluding remarks the project is inspired from nature backed with ai and stemmed with the expertise of mine and prof spadiuts in producing recombinant bioactive protein from bacterial ibs while tu wiens decades of experience in commercializing the technology will be a fertile playground to bow the seeds of a sustainable ligninolytic technology
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traditional knowledge for the conservation of the silk roads monumental terracruda sculptures
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it is in central asia that more than 2000 years ago the art of making monumental terracruda sculptures become one of the most significant expressions of knowledge transfer along the silk roads despite the wide distribution of this art and its historic relevance we still lack a scientific understanding of the manufacturing of these sculptures consequently preservation remains a challenge recent studies have shown that monumental terracruda sculptures are still produced in some areas of himalaya bhutan and india west bengal and although the precise materials may vary the technological pattern remains unchanged over time this pattern is the result of a specific knowledge acquired and transmitted over centuries tantric will study and valorise this traditional knowledge to unveil the cultural significance of this unique artistic practice as well as to inspire through scientific criteria innovative and sustainable solutions for the conservation of these sculptures tantric proposes an interdisciplinary methodological framework in the domain of heritage science combining ethnographic research materials science and conservation the objectives are 1 documenting the empirical knowledge of making these sculptures 2 analysing samples of archaeological sculptures to compare ancient and contemporary materials and additives 3 carrying out a battery of simulationstests to analyse the behaviour and properties of the claybased mortars inspired by traditional recipes the expected results will be a improving the understanding significance and evolution of the artistic practice of making monumental terracruda sculptures b enhancing and valorising the traditional knowledge for making these sculptures c informing new evidencebased conservation treatments d demonstrating that exploring the traditional use of green materials represents an innovative solution for the design of more sustainable and responsible heritage conservation strategies
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identification of cellular regulators and pharmacological inhibitors of endophilina3 to modulate its endocytic functions
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in addition to classical clathrinmediated endocytosis mammalian cells have clathrinindependent endocytic cie mechanisms among others the bar domain proteins that sense and induce membrane curvature are key players in cie in particular the bar domain protein endophilina3 endoa3 drives cie of the cell adhesion molecules cd166 l1cam and dicam with implications in tumour progression and viral infection the regulation mechanism and functional implications of this recentlyidentified endoa3mediated cie route remain poorly characterized in this context i propose an interdisciplinary project combining cell biology chemical biology and virology approaches to substantially advance our understanding of endoa3mediated cie the first research goal is to identify cellular regulators kinases phosphoinositides that modulate endoa3mediated endocytosis in parallel this project aims at identifying small molecule inhibitors that selectively inhibit the endocytic functions of endoa3 subsequently the cellular regulators and pharmacological inhibitors identified in this project will be used in cells to modulate endoa3mediated endocytosis and study the impact on cellular functions emphasis will be put on cancer cell properties and endocytic viral particle entry together this project will generate highquality fundamental knowledge on the mechanism and function of endoa3mediated cie moreover the identification of modulators of endoa3 endocytic functions will provide valuable biological tools for the study of this recentlyidentified cie route in physiology and pathology lastly the identification of selective pharmacological inhibitors may pave the way towards the development of innovative antiviral and anticancer therapeutics targeted at unconventional endocytosis this fellowship will be conducted in the laboratory of prof henrifrancois renard unamur belgium who has been a pioneer in the identification of barmediated endocytic routes
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age of moderation liberal patriotism in the mediterranean 18141848
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this project will investigate the transnational conceptualisation and diffusion of moderate liberal thought in mediterranean europe in the first half of the nineteenth century it will explore moderate thinkers formulation of a third political way for the future of europe between revolution and reaction by focussing on their transnational correspondence across france switzerland italy greece and spain while historians have largely neglected the study of moderation theory by regarding it as an unoriginal and selfserving strand of thought this projects overarching argument is that moderation theory was an original strand of liberalism which southern europeans in dialogue with their northern neighbours conceptualised and implemented as an alternative to the political challenges of the revolutionary age the proposed research presents two new dimensions first while historians have recently studied moderation theory in national contexts this project will be the first transnational history of moderation theory in nineteenthcentury europe the international scope of moderate liberalism and its application in different national contexts are revealing of its significance in postrevolutionary europe the second original dimension is that this project will use moderation theory to investigate the transnationalism of nationsinthemaking in the nineteenthcentury mediterranean as scholars have recently started studying the modern mediterranean as a transnational zone of contact this project will add a further dimension by focussing on moderation theory as a primary trigger for intellectual encounters in the mediterranean in the nineteenth century
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deployable decisionmaking embracing semantics for robotic safety in everyday scenarios
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recent breakthroughs in machine learning have opened up opportunities for robots to build a semantic understanding of their operating environment and interact with humans in more natural ways while machine learning has unlocked new potentials for robot autonomy as robots venture into the real world physical interactions with the surrounding environment pose additional challenges one typical challenge in practical applications is providing safety guarantees in robot decisionmaking much of the safe robot decisionmaking literature today focuses on explicit safety constraints defined in the robot state and input space however in practical applications robots are often required to infer semanticsgrounded safe actions from perception input while recent machine learning techniques are increasingly capable of distilling semantic information from perception translating the semantic understanding to explicit safety constraints is nontrivial in this proposed project we aim to close the perceptionaction loop and develop mathematical foundations and algorithmic tools that enable robots to make intelligent and semantically safe decisions
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progressing promising skills to work in bulgaria proskills2work
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the main goal of proskills2work is to raise the international research visibility of the institute of philosophy and sociology ips of the bulgarian academy of sciences and to develop its traditionally strong focus on sociology of education and work towards a worldclass level of research excellence this will be achieved by advancing scientific knowledge on the bulgarian vocational skills formation system continuous skills enhancement individual transitions from education to work and workplace learning alongside the respective methodological challenges the projects research component will advance scientific knowledge by further developing sociological concepts which allow for analysing the complex relationship of education and work in the current societal and economic context of bulgaria five specific objectives will guide the implementation of proskills2work 1 appointment of prof dr christian imdorf to establish and lead the era chair research unit 2 develop the research and innovation capacity of the ips towards international excellence 3 ensure the constant development of various skill sets and competencies among ips researchers 4 implement structural changes to create the conditions to achieve research excellence on a sustainable basis 5 position the ips as a hub for scientific excellence and policyrelevant stakeholder exchange on progressing promising skills to work through the institutionalisation of a future bulgarian observatory of education and work the increase of research capacity at ips by the era chair unit is expected to promote collaborations between research teams in the ips and external research groups as well as translating research results into policy recommendations and innovative models of vocational skills formation in bulgaria and the western balkans importantly this agrees with the recent european union eu and social partners commitment and upcoming action plan to address labour and skills shortages in bulgaria
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integrated structural and probabilistic approaches for biological and epidemiological systems
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systems in nature are extremely robust despite huge uncertainties and variability studying their nonlinear dynamic behaviour is challenging due to their complexity and the many parameters at play but crucial to understand important phenomena such as cellular dynamics onset of diseases epidemic spreadingparameterdependent simulations can predict the behaviour of natural systems case by case yet the exact models and parameter values are poorly known while qualitative behaviours are often preserved even with huge parameter variations because they rely on the system interconnection structure parameterfree structural approaches can check whether a property is preserved for a whole family of uncertain systems exclusively due to its structure however when an expected property fails to hold structurally novel approaches are needed to understand why which system features prevent it which key parameters must be finely tuned to enforce itinspire will develop a unifying framework to analyse and control families of uncertain dynamical systems in biology and epidemiology which integrates for the first time structural robust and probabilistic methods tailored to the peculiarities of natural systemsthe project will provide i methodologies to assess practically structural properties and unveil the mechanisms that enableprevent a property identifying the key parameters or motifs ii control paradigms that leverage such an insight to guarantee a desired global property through targeted local interventions iii scaling and aggregation approaches that exploit the properties of subsystems to mitigate computational complexitythe project outcomes a mathematical theory as well as algorithms to analyse and control complex uncertain systems in nature will strongly support the analysis and design of biomolecular feedback systems with a desired behaviour the identification of therapeutic targets the prediction and control of epidemic phenomena
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energetic solar eruptions data and analysis tools
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the soler project will investigate energetic solar eruptions starting from three perspectives fast coronal mass ejections cmes strong xray flares and large solar energetic particle sep events key parameters of the eruptions will be determined and their interrelations examined to improve our understanding on how the eruptive phenomena are linked how they interact with each other and how they result in acceleration of high energy particles and their release from the solar corona into interplanetary space largeamplitude coronal waves and shocks related to these events as well as magnetic connections of the radiation sources with the insitu observers will be in focus as wellsoler will answer three science questions what are the magnetic connections between em radiation sources in the low corona and in the high corona and how are they connected to the particle radiation observed in situ what is the relation of the properties of the insitu sep observations with the source characteristics and between the source characteristics themselves what are the reasons for the large variations in sep properties and associated flare and cme characteristicsrelated to these scientific questions soler has also technical objectives soler will deliver interlinked catalogues of strong flares fast cmes and large sep events deliver new tools for analysing and visualising solar eruption datasets and modelling results and distribute them openly to the scientific community produce several highlevel multiinstrument datasets and distribute them openly to the scientific communitysoler will use esa nasa and national mission data along with groundbased observations and a variety of innovative data and image processing techniques together with cuttingedge models soler analysis activities will directly lead to dozens of scientific publications catalogues datasets and tools will be openly available for the community for further exploitation of data
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designing stretchable hydrogel electrolytes and 2dimensional mxene electrodes for energy harvesting via ionic thermoelectrics
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recently energy harvesting technologies based on the concept of thermoelectricity with direct conversion of waste heat into electricity has received great attention thermoelectric te devices have already been used in various industries such as combustion engines coupled to photovoltaic cells and to power small home appliances conventional te devices based on electronic conducting materials working through the thermodiffusion of electrons and holes have been intensively studied and achieved significant performance innovations however the small electronic seebeck coefficient 100 v k1 limits their practical applications at the same time these devices cease to work as temperature difference diminishes and are not capable of storing charge most of them are based on hard inorganic materials with nolimited flexibility and are not applicable in wearable applications therefore it is necessary to develop new electrolytes with a high seebeck coefficient and large surface electrodes for high charge storage capability to solve these issues in this project we propose the development of stretchable hydrogel electrolytes and 2dimensional 2d mxene electrodes the proposal consists of 1 design and synthesis of the stretchable hydrogel electrolytes that exhibit intrinsic stretchability 300 and humidityindependent high ionic seebeck coefficient 50 mv k1 2 realizing 2d mxene electrodes capable of high capacitance 500 fg 3 fabricating energy harvesting and sensing devices based on ionic thermoelectric this project will give an opportunity for the researcher to gain stateoftheart knowledge on ionic thermoelectric materials and devices the experience of the supervisor in various thermoelectric generators will also be fully exploited through this project our proposal will contribute to materials science particularly in energy harvesting society polymer electrolytes and 2 dimensional mxene materials
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a multidisciplinary and circular approach towards the development of innovative safebydesign biodegradable multifunctional coatings
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despite the relevance of polymers eg coatings in modern societies the limited or absent biodegradability and recyclability associated with this class of materials pose serious environmental and health concerns addressing this challenge is thus a key priority being fully aligned with the eu green deal and the un sustainable development goals to bridge this gap a multidisciplinary team with researchers from seven countries including one associate partner has converged to achieve pioneer breakthroughs under the safercoat projectin this sense safercoat aims to promote staff mobility and knowledgesharing to develop ecofriendly polymeric coating formulations with enhanced biodegradability for aeronautical maritime and cultural applications safercoat will focus on the i synthesis and modification of thermoplastic and thermosetting polymers to accelerate their degradation rate at the endoflife ii optimization testing and validation of coating formulations for targeted applications iii assessment of the environmental and health impacts and iv upcycling of endoflife materials to produce addvalue products this scientific endeavor will rely on the synergy of specialized training and crosssector and interdisciplinary mobility among the 6 universities and 4 industrial partners to promote knowledge growth transfer dissemination and exploitationthe novelty of safercoat lies in incorporating high biosourced content and cuttingedge technologies to develop coatings with outstanding performance throughout the service life and high biodegradation after use which will contribute to i decrease the coatings industrys environmental footprint ii revolutionalize the coatings endoflife by transforming what is currently treated as a disposable waste into valuable products contributing for a zero pollution environment and iii settle an international rd network to ensure permanent progress on biodegradable and sustainable coatings
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automated crowd simulation with artificial intelligence
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with the transformation of transportation from individual to public transport and the new climate goals of the european green deal public transportation faces major challenges in the coming years the number of passengers is expected to more than double stations must be quickly expanded to accommodate the increasing number of passengers remodeling existing stations is more complex than building new ones is error prone and quickly lead to costs and time explosionsnew methods technologies and processes are needed to solve this our project automated crowd simulation with artificial intelligence acsai focuses on exploring and combining existing deep tech solutions into a new one bim in combination with crowd simulation enables planners to digitally prototype buildings at early planning stages to prevent costly mistakes although bim speeds the process of data preparation a high computational effort is needed for the execution as a result only a few design variants or scenarios can be analysed as of todayto overcome this issue we combine simulation models with machine learning methods ai models shall be developed and trained with the help of precalculated simulation data the trained nn can give answers at the push of a button whether a design is compliant or not this accelerates the process enormously since it quickly sorts out designs that are not feasible thus only prechecked design variants will be simulated for final confirmation and optimisation the whole approach is a quantum leap in the planning process since it speeds it up and reduces the risk of planning mistakes enormouslywe have tested the approach for railway stations in a poc environment in the research project beyond the next step is to implement it in our crowd simulation software into a readytomarket product as a small company we cannot afford such big rd projects on our own and as a femalefounded company we hope to be a role model in a maledominated sector
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molecular mechanisms behind filovirus entry and egress the role of viral glycoprotein glycosylation
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filoviruses are amongst the most dangerous human pathogens they pose a great health concern due to a growing number of emerging species that vary in tropism and pathogenicity in my work i aim at establishing a correlation between filoviruses pathogenicity the characteristics of their interaction with the cell membrane and their entry and egress potential in this context i hypothesize that viral carbohydrates are key in modulating these processes for this study i have selected a number of filovirus species distinct in their pathogenicity for humans i will use a transcription and replication competent virus like particle system trvlp as a bsl2 virus model and will produce particles presenting the glycoproteins gp from the different filovirus species of interest gp is the sole glycoprotein found on the virus surface and is crucial for filovirus attachment and entry using an interdisciplinary approach combining virology biophysics and glycobiology i will first carry out infection assays to characterize the entry and egress potential of the different particles i will further investigate the role of two key attachment molecules heparan sulfate and dcsign in modulating those processes this will be achieved first on the cellular level and then on the molecular level using single molecule force spectroscopy to look at the characteristics of individual ligandreceptor bonds extensive glycomic analysis amongst other via mass spectrometry will further address the hypothesis that the gps glycan profile plays a key role in determining the behaviour of the different filoviruses taken together i will provide a comprehensive description of the influence of the different gps in viral entry and egress on the molecular functional and biological levels such insights will without doubt be key to the development of efficient and broadspectrum antivirals
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dwelling with crisis home at spaces of chronic violence
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this project elaborates ways of making home among those dwelling in societies facing protracted crises it traverses through various landscapes to look at ways in which people make home in spaces that are familiar yet repelling incapacitating and altogether negating in nature such landscapes notably in lebanon the west bank and gaza reflect various forms of crises engendered around economic collapse infrastructural shortage prolonged conflictsituation andor continuation of war by other means these crises force us to pose a key question on what it means to stay and make a home in spaces that constantly expose life to disruptions incapacitations and material negations how does one dwell in crisis the project responds to this research challenge via groundbreaking research that goes beyond the stateofart on three fronts firstly it generates vast empirical knowledge on what it takes to dwell in crisis and conflict areas and with the political conditions they establish by focusing on spaces that violently separate distance and amputate people from their familiar everyday spaces through constant affective disruptions material deprivations and conditions of incapacitation secondly it does so by developing negativity as a novel methodological tool for approaching dwelling as a tension between homemaking and spaces of exposure thirdly it offers a novel conceptual elaboration of negativity as a worldly condition which challenges the paradigmatic notions of materiality affect and dwelling in current posthuman thought designed for highgain outputs the project takes a high risk in offering groundbreaking research that aims to fundamentally rethink the negative foundations of humanworld relationship by focusing on ways in which negative material and affective bindings align with incapacitating political conditions in prolonged crisis and conflict situations
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harnessing an energyexpending appetitesuppressing fatbrain axis to unlock novel pharmacotherapies
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obesity and cardiometabolic diseases are global crises that threaten to cripple healthcare infrastructures these disorders originate from an excess calorie burden caused by consuming too much food and expending too little energy yet despite recent advances in obesity drugs weightlowering pharmacotherapies only reach about half the efficacy of surgical interventions this difference could be due to existing drugs only acting to reduce food intake and not boost calorieburning therefore i believe our discovery of a leptinindependent signaling axis between adipose tissue at and the central nervous system cns that both decreases food intake and increases energy expenditure poses a breakthrough in obesity research we uncovered this axis through receptor profiling and human genetic association studies and engineered a highly selective agonist that significantly decreases bodyweight and improves glucose and lipid homeostasis in obese mice our preliminary data have already led to a spinout company however the physiological signaling mechanisms of this receptor in at and the cns that shape systemic energy balance through peripheral calorieburning and central control of food intake remain unknown thus in heatup we will delineate at and cns receptor circuits with single cell resolution and functionally test this signaling in 3d cultures of mouse and human at tissuespecific contributions to wholebody metabolism will be assessed by combining our proprietary selective agonist with stateoftheart viral genetic and surgical manipulation of the receptor and neuronal wiring in at and the cns viral and genetic celllabeling strategies will be used to characterize novel secretory cells that we found in mouse and human at to contain the ligand for this receptor collectively these studies will provide a comprehensive physiological overview of a previously unknown fatbrain signaling axis and insight into its potential for counteracting metabolic diseases
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timescalecontrolled transformations for colloidal multielemental nanocrystal design
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colloidal nanocrystals ncs represent an exciting material class where surface and finitesize effects result in prominent physicochemical phenomena bottomup colloidal methods have demonstrated unmatched control over nc properties by enabling their synthesis with defined sizes shapes compositions elemental distributions crystal habits and surface chemistry however the field is moving toward sophisticated nanomaterials where complex compositions unconventional elemental mixing patterns and precisely engineered lattice defects offer advanced optical and catalytic functionalities among others unfortunately these nc features and their technological impact remain largely unexplored due to the high energy barriers and outofequilibrium conditions often associated with the required synthesis processwith time4nano i envision establishing a novel bottomup colloidal methodology timescalecontrolled nc transformations tnt where the combination of pulsed laser irradiation and wetchemical strategies are exploited to create highly outofequilibrium conditions required for multielemental nanomaterial creation to achieve this i will interrogate the interplay between laser conditions chemical and colloidal environment and nc characteristics in the controlled transformation of colloidal nc chemical composition objective 1 elemental distribution objective 2 and lattice defects objective 3 if time4nano succeeds it will bridge current knowledge gaps in tnt methodology paving the way for nanoscale matter manipulation by merging laser technology and wet chemistry in an unprecedented manner this will lay a foundation for producing nanomaterials with tailored physicochemical functionalities promising transformative advancements in areas like catalysis energy storage sensors and optoelectronics
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terahertz optoelectronics in bilayer graphene
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the terahertz thz spectrum which lies on the seam between the optical and electrical spectral ranges is ubiquitously important for science and technology from chemicalbiological sensing to stellar exploration nevertheless the development of thz applications has been hindered by the sparsity of highperformance and lowcost optoelectronic devices due to the limited response of common electronic and optical materials in this spectral range here i propose to develop a new thz optoelectronic platform that is based on 2d materials of bilayer graphene structures taking this approach i will realize a variety of new thz optoelectronic devices that can be electrically controlled and are highly compact and lowcost outperforming the state oftheart topblg will constitute a transformative breakthrough in thz optoelectronic devices beyond thz technology i envision that topblg will have great impact on the integration and dissemination of 2d materials into the microelectronicsoptoelectronics technological market
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ultrastable highly efficient lowcost perovskite photovoltaics with minimised environmental impact
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the decarbonization of the energy sector to mitigate climate change is a key challenge for the european union eu this mandates a rapid and widespread implementation of a clean and affordable energy infrastructure in which photovoltaics pv will be a main pillar currently pv represents only a small fraction of the global energy supply and pv modules are almost exclusively imported from outside the eu associated with supply risks and a high co2footprint emerging perovskite pv has a tremendous potential to overcome these issues and revolutionise the eu energy sector to unfold this potential the diamond project joins 6 european leading universities ugroningen uuppsala epfl urometv uporto umarburg 2 research institutes fraunhofer ise cea and 4 industry partners dyenamo bedimensional solaronix pixelvoltaic from 7 different countries to develop ultrastable highlyefficient and lowcost perovskite pv with minimised environmental impact to achieve stabilities far beyond all previous achievements of pv solar cells the project targets to develop novel hermetic encapsulation approaches and highly stable device designs that are evaluated by standardized and novel stability assessment methods diamond also aims to optimise materials and cell stacks to reach efficiencies exceeding the record values of silicon pv fully printable module architectures are targeted for rapid industrial upscaling allowing for lowest manufacturing costs and local production in the eu to minimise the ecological impact specific device designs that enable lowest co2footprint material criticality and toxicity together with enhanced recyclability are targeted combining these ambitions diamond strives to provide a strong impact on the eus future environmental economic and societal development paving the way for an eumade sustainable energy technology with lowest co2footprint that ensures a full integration into the circular economy
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identity compression a fundamental breakthrough in social identity social information and social polarization
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the breakthrough to be pursued in idcompression is that social polarization is information compressibility where attitudes provide redundant information about group membership idcompression proposes that a polarized social information system is a socially comprehensible one where it is easy to categorize people into groups and identify social outliers since comprehensibility depends on regularities this will consequently be a compressible social information system if successful this radical theory of social normativity will explain how 1 social identity becomes embedded in social information via social interaction 2 information thereby becomes comprehensible in social identity terms 3 comprehensibility of identityladen social information is a form of information compressibility 4 compressibility facilitates group processes making positions comprehensible and socially meaningful 5 the structure of the social information system provides conversion pathways where a the probability of someone taking a new position depends on the ones they already hold b taking a new position shifts the holders identity and makes a new range of positions accessible c chains of transition probabilities form pathways through the identityinformation space and d the structured social information system is dynamically constituted by the positions expressed by the people within it 6 compressible social information systems are ripe for pernicious polarization particularly in situations of intergroup threat affective polarization or zerosum outcomes 7 social media interlocks with psychosocial processes in ways that can accelerate pernicious polarization this radical new understanding of social normativity will show how social identity dynamically interfaces with social information allowing us to understand how important social issues eg climate change global health crises become identitycharged and polarized
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an innovative implantable device and management platform to prevent chronic fluid congestion
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pathologic fluid overload is a main clinical complication of congestive heart failure chf chf is a severe chronic disease affecting 28 m people worldwide around 8 m of chf patients are resistant to oral medications and undergo frequent hospitalizations to remove extra fluids with aggressive acute treatments all carrying severe complications none of these treatments can prevent fluid accumulation the israeli sme paragate medical has developed filbert a unique implantable peritoneal ultrafiltration system for diuretic resistant chf patients it enables 247 monitoring and gentle draining of extra fluids in the urinary system preventing their accumulation a remote treatment management platform allows physicians to continuously control patients conditions and timely adjust therapy to prevent fluid accumulation filbert shifts the paradigm of fluid congestion care from the hospital to the home improving patients quality of life and saving billions to healthcare systems
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a dynamic ultrastable randomaccess rna retrieval database
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in order for dna to become the information storage medium that serves as an alternative to existing digital storage solution technologies information must be stored stably in it with the means to repeatedly access and manipulate parts of the stored data only few in vitro approaches are capable to address some of these requirements while in vivo approaches still produce largely static data storage libraries which limits the reallife applicability of these technologies in this proposal we present a new regeneratable solid state storage system consisting of beads where information encoded in single stranded dna strands can be added selectively accessed and removed using enzymes and nucleic acid strands as inputs for the different data operations in isothermal reactions with no loss of material to achieve this a strand architecture is proposed where unique data id sequences are used on the targeted data strands for performing the intended data operations via enzymatic reactions addition deletion of data and transcriptionbased data access furthermore a variant of this system is proposed that uses rna molecules for the selective access of the data strands which we aim to implement in a bacterial data storage system as well where rna encoding bacteriophages will be used as a noninvasive way to introduce inputs for the data operations such as random data access and removal finally we present the use of damage suppressor proteins from extremotolerant organisms complementing the in vitro and in vivo system to provide the longterm stability of dna observed in resilient biological systems
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pebble growth and drift across gaps carved by giant planets
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the intricate processes governing the birth of planets take place inside gaseous protoplanetary discs around young stars when planets grow beyond neptune in mass their gravitational influence perturbs the gas density in their vicinity creating pressure bumps or shallow gaps that effectively halts the inward drift of millimetre to centimetresized dust aggregates often referred to as pebbles from the outer reaches of the disc consequently pebbles accumulate at these pressure bumps creating dust rings observable through observatories such as alma classical numerical simulations of planet formation frequently assume a monodisperse pebble size distribution contrary to revelations from prototoplanetary disc observations where pebbles come in various sizes and compositions influencing the dynamics of planet formation the planetdiskos project aims to develop a comprehensive model that considers grain size evolution and pebble filtration by gas giants while accounting for variations in pebble composition and porosity a novel methodology is proposed to model selfconsistent grain size evolution and pebble filtration by gas giants this approach promises to enhance our understanding of the prevalence of superearths in the presence of outer jupiterlike planets and the heavy element content of gas giants synthetic exoplanet simulations will be conducted integrating compositional properties to compare with observed exoplanet populations early results from my numerical simulations of pebble filtration demonstrate the potential to achieve the goals of the project working with a team of experts in planet formation and cosmochemistry at starplan i will acquire the needed skill set to execute the planetdiskos project opening new avenues for advancing the theoretical framework of exoplanet formation
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next generation battery management system based on data rich digital twin
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the eu roadmap towards a climateneutral economy by 2050 sets ambitious decarbonisation targets that shall be achieved by a massive deployment of renewable energy sources energy storage improves grid flexibility and allows higher penetration levels of renewable energy sources to create a decarbonised and more electrified society by means of leveraging secondlife batteries battery management plays an essential role by ensuring an efficient and safe battery operation however current battery management systems bms typically rely on semiempirical battery models such as equivalentcircuit models and on a limited amount of measured data therefore energetic project aims to develop the next generation bms for optimizing batteries systems utilisation in the first transport and the second life stationary in a path towards more reliable powerful and safer operations energetic project contributes to the field of translational enhanced sensing technologies exploiting multiple artificial intelligence models supported by edge and cloud computing energetics vision not only encompasses monitoring and prognosis the remaining useful life of a liion battery with a digital twin but also encompasses diagnosis by scrutinising the reasons for degradation through investigating the explainable ai models this involves development of new technologies of sensing combination and validation of multiphysics and data driven models information fusion through artificial intelligence real time testing and smart digital twin development based on a solid and interdisciplinary consortium of partners the energetic rd project develops innovative physics and databased approaches both at the software and hardware levels to ensure an optimised and safe utilisation of the battery system during all modes of operation
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elucidating the cellular basis of therapeutic resistance in crohns disease
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crohns disease cd is a chronic inflammatory disease that affects the gastrointestinal tract affecting millions of people worldwide and presenting a considerable economic burden to health systems cd has a serious impact in quality of life not just physically but also emotionally and socially pathogenesis results from a complex interaction between environmental factors microbiome genome and inflammatory system leading to disruption of the intestinal mucosa the imbalance between inflammatory and regulatory cells in maintaining an active disease is well known and most therapies aim to stop the cascade of inflammatory and proinflammatory cytokines ie tnfblockade one of the major challenges for treatment is the fact that not all patients respond to therapy moreover the mechanisms behind resistance are still not completely understood making it hard to correctly stratify patients as responders and nonresponders at time of diagnosis we aim to elucidate changes in immune regulation that explain primary response failure to tnfblockade in cd we hypothesise that dysfunction of regulatory cells may prevent reinstatement of homeostasis following inflammation targeting we will establish singlecell transcriptomics of immune cells from biopsies at the time of diagnosis as well as in patients responding to treatment and nonresponders then we will use computational methods to investigate how immune cells change with time acquiring a state supporting therapeutic resistance moreover we will illuminate the relationship between immune dysregulation and anatomic niches using spatial transcriptomics finally we will analyse paired peripheral blood samples for the identification of putative biomarkers for stratification of patients according to tnfblockade response this proposal will provide unprecedented insights on the mechanisms involved in therapeutic resistance in cd which could potentially lead to the development of new treatment approaches
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the hidden majority highresolution imaging and genomics of the most ecologically important microbial eukaryotes in the ocean
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how have eukaryotes evolved into the vast diversity we see nowadays at present this simple question remains a mystery mostly due to the vast uncharted microbial environmental diversity recurrently unveiled by molecular surveys this gap in knowledge hinders a deep understanding of basic eukaryotic diversity evolution and biology and creates a biased perception towards wellcharacterized organisms of human interest yet since the beginning of microbial research from leeuwenhoek and haeckel unicellular eukaryotes have been largely studied by optical methods describing an extensive variety of shapes and morphologies we therefore need new and different approaches to explore unknown eukaryote diversitythe goal of this project is to better understand early and enigmatic eukaryotic evolution by studying the morphology and genomes of the most informative undescribed eukaryotic lineages studies of novel eukaryotic diversity have historically relied on arbitrary factors regardless of their environmental abundance due to the lack of data yet abundant groups are the most practical to explore i will first identify the most environmentally abundant species that are distantly related to morphologically described groups next i will develop a novel approach that allows the acquisition of 3d morphological data by imaging groupspecific fluorescence in situ hybridization probes in combination with a set of fluorescent dyes labeling relevant subcellular features finally i will sequence and assemble their genomes to better resolve the eukaryotic tree of life by filling out poorly represented lineages that are distantly related to wellcharacterized species this project will bring for the first time the link between already available environmental short sequences and their organismal morphology and genomic data
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twinning action for spreading excellence in artificial intelligence of things
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aiotwin is a twinning coordination action for spreading excellence in artificial intelligence of things bringing together researchers from three european universities unizgfer tuw and tub and one research institute rise the goal is to significantly strengthen the scientific excellence and innovation capacity of unizgfer in the area of the internet of things through knowledge transfer and strategic networking activities between unizgfer researchers and worldclass scientists from leading eu institutions this will be achieved through an elaborate work plan and a comprehensive set of activities that will increase the mobility of researchers and improve the scientific and innovative capacities as well as the attractiveness and visibility of unizgfer in the european research area aiotwin identifies four research domains relevant to aiot 1 edge computing and orchestration 2 federated and decentralised machine learning 3 ai for robust and energyefficient iot and 4 distributed ledger technology dlt for iot which align well with current research directions leading to the new evolutionary phase of nextgeneration iot the knowledge gained through the networking activities in the rds will be the driving force for conducting a joint research project on datadriven orchestration middleware for energyefficient iot supporting ml workflows the middleware will be tested on a selected use case using the consortiums shared infrastructure in addition the project will strengthen the research management and administrative skills of unizgfer staff aiotwin provides a unique opportunity for unizgfer researchers to work closely with leading international researchers to develop new ideas foster creativity and strengthen the impact of all participating partners on an international level it will contribute to strategically reduce disparities between croatia and other eu member states participating in the horizon europe programme
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nanostructures and nanoelectromechanical devices for precise control of topological defectsmatter in superfluid helium
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since richard feynmans famous talk there is plenty of room at the bottom in 1959 the following decades saw the booming of nanotechnology one of the fields in which nanotechnology can never be ignored is the development of scientific instruments scientific instruments based on nanotechnology have revolutionized many research fields however using current instruments to study superfluid he is still challenging especially for the topological defects tds and topological matter tm because the scale of the coherence length of the interesting objects in 3he is just tens of nanometers the n2pcon nanostructures and nanoelectromechanical devices for precise control of topological defectsmatter in superfluid he project will offer a nanotechnology solution to precisely control and study tds and tm in this action i will work in the otanano finnish national infrastructure for nanoscience and nanotechnology at aalto university with the supervision of dr sami franssila department of chemistry and materials science and dr vladimir eltsov department of applied physics at the same time i will also work with my secondment institutes royal holloway university of london uk and lancaster university uk to boost this action the action will produce nanoscale instruments nems nanostructures that surpass the current stateoftheart devices in both performance and dimension to reach the quantum world of tds and tm n2pcon is expected to provide new tools for superfluid research and also add general knowledge to memsnems and cosmology in the long term it will boost the memsnems research and industry in the eu
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soft organic electrochemical neurons for biochemical sensing and delivery
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recent advancements in prosthetics braincomputer interfaces and neural therapy require electronics that communicate with biological systems however electronic circuits manipulate 10 binary digits whereas biological neurons function with ion fluxinduced neural spikes to emulate biological neuron functions in hardware implementations artificial neurons have been developed using inorganic memristors or transistors but they have failed to integrate with biotic neurons due to their high operating voltage and inherent inertness towards ionneurotransmitterbased modulation in this regard organic electrochemical transistors oects distinguish themselves by using ionic species to mediate electronhole conductance in organic semiconductors making them the ideal candidate for fabricating organic electrochemical neurons oecns with high biocompatibility and biochemicalmediated functionalities so far oecns have been demonstrated by the project host prof simone fabiano at linköping university with the capability to emulate biorealistic spiking patterns response to exogenous ions or neurotransmitters for spiking modality alternation and perform eventbased neuron stimulation in animal models however existing oecns still face two major limitations that impede their integration with biological nerves including their rigidity and incapable of performing endogenous biochemical sensing and modulation with biotic neurons to exploit the advantages of oecns for biointegration and bidirectional communication i will use my expertise in soft materials devices and systems to devise oecns with tissuelike softness monolithic assembly and seamless integration with biological nerves specifically stretchable organic semiconductors and other soft constituent materials will be synthesized and prepared soft oects and oecns that operate stably under mechanical deformation will be devised soft biochemical sensing and delivery functions will be incorporated
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exploring the effect of seedlings drought vulnerability on treeline dynamics under climatic change using quantitative wood anatomy
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global warming has modified the distribution of some forests growing at their altitudinal limit treelines some have been advancing leading to loss of alpine biodiversity and changes in surface reflectance of mountain and polar areas others remained stable leaving a lag between the position of uppermost tree stands and the treeline isotherm ti common seasonal mean temperature indicative for potential treeline position despite these striking worldwide patterns there is a lack of systematic observation to understand the drivers of differential treeline response to global warming the extent of the treeline lag behind warming may be associated with seedlings survival however as temperature is considered the main factor responsible for treeline the role of seedling drought sensitivity as driver of differential treeline response to global warming is poorly understood certain xylem anatomical traits xa such as conduits wall thicknessarea ratio conduits area and layers pits and parenchyma area may confer drought adaptations ultimately affecting survival and growth under increasing warming conditions the proposed research will help understand the drivers of differential treeline response to global warming i will analyse the effect of xa on the distance of the uppermost tree stands to ti in representative european treeline tree species we will determine the treelines lag across several regions i will quantify xa and their plasticity and correlate them with treeline position my contribution to achieve the project objectives relies on quantitative wood anatomy experience for studying drought adaptations in tree species and examining patterns between drought resistance and anatomical variation this project brings me experience abroad to get a permanent position at a highquality research institution with a highlife quality focusing on independent research on wood anatomical influence on plant function under stressful environments
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lifehistory genes in fishes bridging functional and evolutionary genetics for understanding lifehistory trait evolution
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life history is one of the most central concepts in biology numerous biological questions ultimately revolve around the causes and consequences of variation in reproduction and survival ie fitness tremendous effort has been put in establishing the causes and mechanisms for life history trait variation and tradeoffs but even in well studied model organisms evolutionary genetic and functional genomic approaches are rarely combined and thus the path from genotype to phenotype often remains a black box a strategy to overcome this major hurdle has recently emerged with the discovery of loci that explain exceptionally large proportions of the variation in various life history traits these lifehistory genes offer new opportunities to study not just the why evolution but also the how functional genetics of life history trait variation i will address critical outstanding questions by bridging functional and evolutionary genetics approaches to study multiple loci linked with lifehistory traits including age at maturity migration timing and migration strategy in 3 fish species atlantic salmon rainbow troutsteelhead and atlantic cod the relatively simple genetic architecture of the traits combined with the features of these species as model systems offer a unique opportunity to finally reveal the genetic architectures molecular mechanisms and ecological drivers that translate largeeffect genotypes into adapted life history phenotypes and examine how evolution shapes these processes in fishlegs i will i characterize the molecular functions behind genotypelife history associations ii elucidate life history trait reaction norms and evolution in variable environments and iii determine the strength of natural and sexual selection on life history traits their sex specific effects and model the evolutionary consequences life history research also has societal relevance for health sustainable fisheries conservation and climate resilience
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realityconnected machine simulation of heavy machinery
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the realsim project proposal aims to connect machine simulation to reality in the framework of heavy machinery which is an interdisciplinary application the results of this project are expected to optimize machine performance accurately and reliably predict machine failure and reduce overall development and operation costs thus serving the europes priority of green transformation and the united nations sustainable development goal 9 the realsim project will close the gaps of 1 onboard estimations of force and pressure components of heavy machinery 2 estimating deformability cylinder friction leakage and valve dynamics of heavy machinery using independent nonlinear kalman filters 3 employing dependent nonlinear kalman filters in state estimators of heavy machinery 4 tuning algorithms for the covariance matrix of plant noise in the state estimation of heavy machinery i will consolidate and leverage my research career and position as a leading researcher in the field through integration in assoc prof mohammad poursinas group at the department of engineering sciences of the university of agder uia norway here i will acquire handson experience of working with actual mechatronic systems and develop efficient control algorithms i will improve my knowledge of fluid power designing control theory instrumentation and develop efficient coding skills i will also develop entrepreneurial skills the skills knowledge and international network that i will develop during this fellowship will put me in an excellent position to achieve my longterm goal of becoming a professor with my own independent research group at an esteemed university in eu this fellowship will help me to prepare a strong erc starting grant application in the future it will also cater my additional goal of settingup a researchrelated startup in the future
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optimization of radio detectors of ultrahighenergy neutrinos through deep learning and differential programming
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detection of neutrinos at ultrahigh energies uhe e 1017ev would be one of the most important breakthroughs in astroparticle physics in the 21st century and would open a new window to the most violent phenomena in our universe radio detection remains the only viable technique at these energies however owing to the expected small flux of uhe neutrinos the detection rate will be small with just a handful of events per year even for large future facilities like the icecubegen2 neutrino observatory at the south pole in this project i will enhance the science capabilities of uhe neutrino detectors substantially by increasing the detection rate of neutrinos and improving the quality of each detected event using recent advances in deep learning and differential programming i will replace the thresholdbased trigger foreseen for future detectors with neural networks increasing the detection rate of uhe neutrinos by a factor of two at negligible additional hardware costs i will perform an endtoend optimization using differential programming and deep learning to improve the determination of the neutrino direction and energymy previous work on developing stateoftheart mc simulation codes my experience in data analysis designing reconstruction algorithms and deep learning and my leadership role in icecubegen2 will enable this erc projectthe timing of this project is perfect for influencing icecubegen2 the largest facility for astroparticle physics with neutrinos for the next decade whose construction is planned to start in 2027 with this erc project icecubegen2 will be able to expedite the discovery of uhe neutrino fluxes by up to a factor of five see sources from deeper in our universe increasing the observable volume by a factor of three and measure the neutrinonucleon crosssection at eev energies with 3x smaller uncertainty hence nuradioopt will substantially increase the capabilities of future observatories for uhe neutrinos
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charles university programme for sustainable goals training openness and novelty in research
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charleston stands for charles university programme for sustainable goals training openness and novelty in research its a unique opportunity inviting 20 exceptional postdoctoral researchers from any nationality provided they meet the msca mobility condition and have a doctoral degree with up to eight years of research experiencecentral to the programme are three key objectives fostering progress towards the united nations sustainable development goals sdgs enhancing support for postdoctoral career advancement and offering fellows enriching intersectoral experiences charleston stands out for its meritbased selection process overseen by independent evaluators in line with charles universitys commitment to equal opportunitiesas a monobeneficiary project charles university not only administers but also directly benefits from this programme hosting research across its 21 diverse faculties and departments the heart of charleston lies in its robust 24month fellowship at charles university supplemented by a mandatory three to six months of practical experience in nonacademic settings this structure is deliberately designed to stimulate curiositydriven research across various scientific fields closely tied to the sdgsmore than just a funding mechanism charleston is a holistic journey in postdoctoral career involving a network of partners for hosting training and broad dissemination of research findings it also provides its fellows with competitive remuneration including mobility and family allowances underscoring its dedication to supporting researchers both professionally and personally
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a datadriven framework towards sustainable reuse of decommissioned petroleum platforms as support structures for wind energy production
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seeking offshore green energy sources with the lowest possible cost and carbon footprint while avoiding any additional oceanic waste is currently a major challenge scientists have been warning about the increase in the number of decommissioned platforms and their potential negative impact on the environment on the other hand the transition from fossil to green energy has become a necessity if we are to reduce the consequences of climate change this means that more petroleum platforms will be decommissioned in the near future dep2wind is an innovative project that deals with these important problems by proposing a mapping framework for the reuse of decommissioned platforms as support structures for wind turbines the project will address the safety and maintenance of these steel structures and how to save on the excessive installation costs of wind turbines the project will take a novel interdisciplinary and mixed reliability optimisation and datadriven approach based on an assessment of the state of the decommissioned platforms as regards corrosion and fatigue the optimum maintenance and repair actions and a suitable design for wind turbines different outcomes will be investigated using quantitative and qualitative techniques the fellow will benefit from the expertise of the structural engineering research group at the department of civil engineering and energy technology at oslo metropolitan university norway building on the fellows previous work and skills in both structural engineering machine learningbased modelling and reliability research the project activities will further develop the fellows professional and academic maturity furthermore the results will have a key impact on the advancement of multiple academic disciplines contribute to the eus green deal and un policies and help to meet the un sustainable development goals by providing affordable and clean energy and improving the quality of marine life
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european communities of facilitators focused on cocreation training networking and handson learning
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expert facilitators lead and guide cocreation processes among stakeholders enhancing creativity and mutual understanding and ensuring effective outcomes to excel in their work facilitators need a diverse set of skills incl technical expertise and soft skills like conflict resolution and active listening keeping up with the latest cocreation trendspractices incl the incorporation of ssh aspects can be challenging although there are many initiatives offering resources to upgrade cocreation skills they are frequently fragmented and scattered through hundreds of platforms and websiteseufficient will create a dedicated platform and methodology to provide facilitators with personalized access to bestinclass cocreation resources as well as training and networking opportunities the platform will allow users to selfassess their training needs in cocreation before they access a customised training program comprising easytodigest audiovisual material online and f2f events upon completion of the training modules expert facilitators will receive a certification of completion aligned with ecs vision for lifelong learning and microcredentialsthe project will pilot four communities of expert facilitators cefs advanced manufacturing healthtech mobility and aidigital facilitating crossfertilization and crosscomparison eufficient targets over 2000 facilitators through the four cefs with at least 500 actively participating in training an activity coordinated by uiin network the eu leader in universityindustry trainingthe partnership brings representatives from academia incl 6 heis industry and the public sector as well as dedicated experts on cocreation training community building online platform development and policy briefing the highly complementary consortium is formed by partners from many different backgrounds and geographies incl widening and associated countries enabling an agile kickstart of the piloting
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comparison and rigidity for scalar curvature
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questions involving the scalar curvature bridge many areas inside mathematics including geometric analysis differential geometry and algebraic topology and they are naturally related to the mathematical description of general relativity there are two main flavours of methods to probe the geometry of scalar curvature one goes back to lichnerowicz and uses various versions of index theory for the dirac equation on spinors the other is broadly based on minimal hypersurfaces and was initiated by schoen and yau on both types of methods there has been tremendous progress over recent years sparked by novel quantitative comparison and rigidity questions due to gromov and by ongoing attempts to arrive at a deeper geometric understanding of lower scalar curvature bounds in this proposal we view established landmark results such as the nonexistence of positive scalar curvature on the torus together with the more recent quantitative problems from a conceptually unified standpoint where a comparison principle for scalar and mean curvature along maps between riemannian manifolds plays the central roleguided by this point of view we aim to develop fundamentally new tools to study scalar curvature that bridge longstanding gaps in between the existing techniques this includes a farreaching generalization of the dirac operator approach expanding upon techniques pioneered by the pi and novel applications of bochnertype methods we will also study analogous comparison problems on domains with singular boundary motivated by a first synthetic characterization of lower scalar curvature bounds in terms of polyhedral domains and by the general quest for extending the study of scalar curvature beyond smooth manifolds at the same time we will treat subtle almost rigidity questions corresponding to the rigidity aspect of our comparison principle
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eyes hearts hands urban revolution
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cities need support to implement their sustainable action plans in line with the ambitious and stringent regulations towards a zero carbon europe the eyes hearts hands urban revolution ehhur project will develop and test a codesigned methodological structure to support cities in their built environment transformation by using already existing good practices and complementing them with the new european bauhaus and eu missions principles 7 lighthouse demonstrators will be involved across eu and associated countries dk el be pt tk hr itehhur will tackle socioeconomic and cultural challenges through relevant case studies facing social segregation vulnerable residents experiencing energy poverty coal transition depopulated and degraded historic centres ehhur relies on engagement and codesign as the backbone of its methodology by deploying a set of tailored social innovation activities aimed not only to engage but also to commit the participation of relevant urban players at multiple and multidisciplinary levels technology codesign cofinancing aesthetic cocreation the ehhur new integrated methodology will cover innovative i engagement practices to transform citizens into active players of their future urban transformation and empower them in the decisionmaking process ii financing schemes involving local businesses and citizens iii digital and green technologies iv architectural design and materials to meet climate change and sustainability challenges while respecting heritage and cultural ecosystems v arts and creative codesign in third sector buildings and public areas the diversified experiences of the lh demonstrators will provide a variety of good practices and guidelines for future replication future adopters will benefit from a dss tool supported by a capacity building programme that offers the ideal mix of best technical solutions optimal financing schemes and engagement tools and social innovation practice
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rethinking affective game epistemologies rage investigating how knowledge is produced and put to use in affective gaming
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affective gaming or gameplay that is influenced by a players emotional state is a research domain at the intersection of hci and affective computing yet the field has stagnated over the years since its inception back in the early 1980s in rage i will revitalize the field of affective gaming by addressing foundational epistemic problems that are contributing to this stagnation rages research objectives tackle explicating unclear and hidden assumptions and value sets in this space and the practical tensions that exist in terms of implementation i analyze the field through both a theoretical lens in the first year and moving to a practical implementation of affective games in the second in this project i will transfer my knowledge in designing and creating affective games for the implementation aspects of rage while prof elisa mekler itu copenhagen denmark will support the theory aspects with this fundamentally interdisciplinary project i will collaborate with and connect many research groups and labs at itu from different disciplines including the center for digital play the affective interactions and relations air lab and the interaction design ixd lab collaboration within this interdisciplinary team and broadening my research portfolio to include theoretical and critical research will allow me to shape a research vision and establish myself as a key researcher of affective gaming within the eu in service of my eventual goal to lead my own research group within the eu
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specializing temporal planning using reinforcement learning
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planning devising a strategy to achieve a desired objective is one of the basic forms of intelligence temporal planning studies the automated synthesis of strategies when time and temporal constraints matter temporal planning is one of the most strategic fields of artificial intelligence with applications in autonomous robotics logistics flexible production and many other fieldshistorically the research on temporal planning follows a generalpurpose framework a generic engine searches for the strategy by reasoning on the problem statement ie the starting condition and the desired objective as well as on a formal model of the domain ie the possible actions despite substantial progress in the recent years domainindependent temporal planning still suffers from scalability issues and fails to deal with realword problems the alternative is to devise adhoc domainspecific solutions that although efficient are costly to develop rigid to maintain and often inapplicable in nonnominal situationssteprl will study the foundations of a new approach to temporal planning that is domainindependent and efficient at the same time the idea is to adopt a framework based on reinforcement learning where a domainindependent temporal planner is specialized with respect to the domain at hand steprl continuously improves its ability to solve temporal planning problems by learning from experience thus becoming increasingly efficient by means of selfadaptationsteprl will advance the state of the art in temporal planning beyond the efficiency vs flexibility dilemma that i had to personally face in the many industrial projects i worked on
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tracking longterm resilience in arctic socioculturalecological systems
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like many indigenous peoples around the world inuit of foxe basin central arctic canada view hunting and the food security it provides to be a collective cornerstone of their cultural identity however much conflict exists between inuit subsistence hunters and regulators over the population sizes of many animal species eg caribou walruses and polar bears and the continued sustainability of hunts inuit argue that governmentsponsored stock estimates are too conservative and that hunting quotas are too low my aim is to better understand and navigate the cultural disjuncture between westernscientific understandings of sustainabilityconservation and inuit traditional knowledge about environmental healthmy team and inuit partners will for the first time generate and integrate different types of data on 1 presentday hunting patterns through citizen science 2 past animalresource use by inuit in foxe basin from ca ad 1300 through archaeological investigations 3 traditional knowledge about hunting and use of animal resources in the region through ethnographic engagement and 4 policy relating to modern and historical hunting regulation and conservation efforts a fifth work package will offer practical datadriven solutions for better relationships between inuit and policymakers and regulators through the creation of a multimedia toolkit that can be used by rightsholders in crossculturally framing discussing and ultimately reaffirming rights over the resources in their traditional territories traces will greatly further our archaeological and anthropological understanding of longterm animal use by arctic indigenous peoples and will have significant implications for how we categorize humans animals and whole biomes as being vulnerable to climate change ultimately the project will serve as a model for environmentrelated indigenous research and policy action elsewhere in the world
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alexandrian scientific tradition in eastern rome europe and syria
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asteres aims to understand how astronomical knowledge developed in alexandria from the works of claudius ptolemy has been transmitted during the 6th and 7th centuries in europe and the mediterranean world through an investigation of documents that had never been edited the project considers the role of greek as well as syriac and latinspeaking scholars in the circulation and reception of greek scientific knowledge before the flourishing of sciences in baghdad and the socalled carolingian renaissance the traditional narrative considers arabspeaking scholars after the foundation of the abbasid califate to be the first heirs to the alexandrian scholarship coming up with greek science only thanks to the mediation of syriac translations it is also widely believed that latinspeaking intellectual circles in western europe would not have been familiar with greek science before the latin translations of arabic texts produced from the 11th century onwards the 6th and 7th centuries in western europe and the byzantine empire have thus been traditionally described as dark ages the aim of asteres is to write a new history of the forms and paths of transmission and study of the alexandrian sciences specifically astronomy in the early middle ages it will investigate three sets of documents including numerical tables produced during this period two astronomical and chronological letters with tables of the syriac scholar severus sebokht will be edited for the first time their study will help to understand to which extent syriac scholars received greek knowledge to create an original scientific production the edition of the latin tables of the preceptum canonis ptolomei aims at understanding how astronomical tables were transmitted and received in western europe before the 11th century the study of the astronomical tables produced by the byzantine scholar stephanos will show how astronomers in constantinople cultivated their alexandrian scientific heritage
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conceptualization and operationalization of minorities in the practice of un treaty bodies
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mincoop is an interdisciplinary and intersectoral project that focuses on the conceptualization and operationalization of minorities under universal international law with the ultimate purpose to improve the legal protection of traditional national ethnic religious linguistic minorities and persons belonging to them the project contributes to a growing area of minority studies setting out from the recognition that international law routinely operates with the concept of minority when providing standards for the recognition of groupspecific rights or protection from discrimination without actually offering definitions on the protected groups conceptualization or membership criteria therein operationalization this in not merely an unresolved theoretical issue but a practical deficiency with crucial importance for the protection of minorities namely ambiguity in the relevant terms hampers the achievement of policy goals and the potential for abuse easily leads to further discrimination and marginalization in order to give definite answers to the problems of conceptualization and operationalization the project proposes to carry out an uptodate systematic and comparative analysis of the monitoring materials of the ten un human rights treaty bodies thus filling an important gap in scholarship the project follows a mixedmethod research design including quantitative computerassisted content analysis and qualitative legal analysis as well as case studies and field research interviews conducted in slovenia the research project will not only inform the theoretical debate on minority rights and provide recommendations for policymaking but also intends to raise awareness of the pressing issues of traditional minorities among the general public promoting more tolerant inclusive societies
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trustml an optimizationbased platform for building trust in machine learning models used for power systems
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deep decarbonization of the energy sector will require massive penetration of stochastic renewable energy resources and an enormous amount of grid asset coordination this represents a challenging paradigm for power system operators with its ability to learn in complex environments and provide predictive solutions on fast timescales machine learning ml is posed to help overcome these challenges and dramatically transform power systems in coming decades emerging eu verification standards however will require that all ml and reinforcement learning rl used in safety critical applications be demonstrably trustworthy in this project we develop a unified framework known as trustml for assessing the quantitative trustworthiness of the neural network models commonly used in power systems trustml uses a novel convex optimization approach to assess ml trustworthiness across three key dimensions performance robustness and interpretability the approach is engineered to be scalable and by design it generates exact verification guarantees furthermore trustml is designed to meet the emerging needs of actual power systems in particular it can verify the performance of multiagent rl systems in rigorous ways and its relaxed counterpart can offer tractable worstcase performance guarantees in the context of online learning the resulting verification tools will be published as opensource software packages and shared widely with researchers and industry this project will advance stateoftheart methods across several interdisciplinary fields it will help remove the barriers associated with machine learning deployment in power systems and its outcomes will help push european power grids into competitive spaces coming from mit with advanced training in power systems the project pi samuel chevalier is characteristically wellsuited to build trustml and his team of advisors represents a mixture of experts across power optimization and learning
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design and implementation of a frequency domain online diagnostic tool for pv modules
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photovoltaic pv generators have been established as one of the most important renewable energy sources in the last years and they will have a main role in the energy transition that is envisaged for the coming years according to the european union recovery plan and the green deal however pv panels may suffer early degradation and failures that affect the pv system reliability and considerably reduce the energy production not only on a specific panel but in the entire string to which the panel is connected therefore it is important to develop diagnostic tools to improve energy yield extend the lifetime of the panels and improve the effectiveness of maintenance activities hence this project aims to develop an online monitoring and diagnostic system for pv panels that uses the impedance spectrum is to detect failures while they are operating at their maximum power point mpp therefore there isnt a reduction in the power produced by the generator and the measurements can be performed within short time frames to detect the failures as soon as possible the proposed diagnostic tool will be formed by an electronic device and a failure classification algorithm running on an embedded system hence the project begins with the design and implementation of the electronic device to generate the signals and implement the measurements required to obtain the is then the project continues with the development of a failure classification algorithm from the analysis of the pv generator dynamic model parameters dmp which are estimated using the iss obtained with the proposed electronic device finally the diagnostic tool will be experimentally validated with pv panels of different technologies and with real failures
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rebuilding governance and resilience out of the pandemic
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culminating more than a decade of crisis in europe the covid19 pandemic has opened an unprecedented window of opportunity for institutional and policy change not only at the reactive level of emergency responses but also to tackle more broadly the many sociopolitical challenges caused or exacerbated by covid19 building on this premise regroup rebuilding governance and resilience out of the pandemic aims to 1 provide the european union with a body of actionable advice on how to rebuild postpandemic governance and public policies in an effective and democratic way anchored to 2 a map of the sociopolitical dynamics and consequences of covid19 and 3 an empiricallyinformed normative evaluation of the pandemic regroup pursues this threefold objective via a multilevel national supranational international and multisphere political societal ideational digital research approach and guided by three overarching analytical themes reordering risk resilience we operate in nine collaborative work packagesgrouped in three blocks diagnosis evaluation and prescriptionbringing together expertise and methods from a range of social sciences and humanities doing so we advance the state of the art conceptually theoretically and methodologically regroup is conducted by a consortium of 13 internationally renowned institutions committed to scholarly excellence inclusiveness and open science the project is designed to achieve a high degree of policy societal and scientific impact which it will achieve via a multipronged dissemination and communication strategy this includes links to some of the eus main debates and events such as the health union the green deal the digital decade the economic governance review the conference on the future of europe and the 2024 european parliament elections
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valorising artistled innovation through citizen engagement
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voice aims to address the complex social and cultural constructs that play a vital role in knowledge valorisation and supporting systemic change in societal response to environmental and ecological sustainability arts and cultural institutions can act as a platform for collaboration between citizens industry and other stakeholders both by providing a cultural space for dialogue and by integrating diverse creative expressions and digital innovation in real world contexts to enhance cocreation with citizens and industry acting in a coordinated manner with shared aims definitions intentions and with an inclusive design methodology underpinning all engagements it is possible to showcase innovative approaches to sustainable design production and consumption that can inspire citizens and industry to think creatively and differently about sustainability challenges voice proposes a distinct approach framed as artistdriven interventions to enable multistakeholder communities to engage in dialogue but also collaborate for codesigned green and digital solutions to remedy regional or local challenges related to environmental and ecological sustainability and leading to a more resilient ecosystem formulated as arttechnologysociety interactions atsi these initiatives will form the backbone of artistled interventions as platforms for dialogue knowledge exchange and transfer among the key playersstakeholders in the voice ecosystem
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women and arabic literacy in congo during the colonial period a double invisibility
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womlit project aims at challenging the invisible presence of women in arabic literacy in congo during the colonial period 18851960 the core assumption is that the grasp of salient feature of the participation of muslim women in literacy is key to understanding islam in central africa womens identity social networks and major inherent gender and class tensions this project is mainly designed to address the historical gap on the absence of women in arabic literacy aiming to bring new female voices to reach these goals and given the significant scarcity of documentation in the field womlit will adopt a transnational sociohistorical and feminist perspective combining oral testimonies archival research and photographic material collected in congo as well as in other locations rwanda burundi tanzania including zanzibar and in the arabian peninsula sultanate of oman the project will address the extent to which muslim womens practices in other swahili areas can be transposable to congo and vice versa addressing their participation in sufi brotherhoods qaradiyya umwali sexual initiation and magic womlit will analyse how the question of archives and the voices they reveal is a fundamental issue for feminist theories this project aims to add new perspectives on the history of the congo as well as the history of oman whose presence in congo remains silenced compared to its influence in east africa womlit is closely related to the research led by the researchers supervisor xavier luffin and his team on arabic literacy in eastern congo burundi and rwanda during the colonial period part of a 4year project funded by the fonds de la recherche scientifique fnrs belgium that will greatly benefit the fellow
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deciphering translocationbased genome topology effects and their role in lymphoma formation
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a central goal in cancer research is to identify the molecular mechanisms underlying tumor formation such as translocations that result in expression of fusion genes or protooncogenes located at the translocation breakpoints while the consequences of this erroneous expression have been widely studied other effects of translocations remain largely unexplored nevertheless these can provide vital new insights into tumorigenesis i hypothesize that translocations disturb the global 3d genome architecture causing alterations in chromosome territory positioning and interchromosomal interactions and that these can account for inactivation of key genomic loci for which the cause of deregulation remains so far unknown i will address this hypothesis in the context of nonhodgkin lymphoma nhlrelated immunoglobulin igh translocations by genome editing we will create lymphoblastoid cell lines and cord blood cellderived b lymphocytes in which igh translocationbased effects can be cleanly dissected in vitro and in vivo in these models we will study how igh translocations affect genome topology the epigenetic and gene expression landscape and nhl formation to that end we will assess i chromosome territory structure and interchromosomal crosstalk by chromatin conformation capture and fixed and livecell imaging ii epigenetic and gene expression maps using bulk and singlecell profiling and iii in vivo tumor formation importantly after exploring the presence of the observed gene expression changes in nhl samples we will target the coinciding changes in in vitro and in vivo approaches to probe their relevance for lymphomagenesis overall lymphotop shall lead to deeper insights into translocationbased genome topology reorganisation and its role in tumorigenesis and to potential identification of new vulnerabilities of lymphomas thus extending its impact to many fields from lymphoma and tumor biology to 3d genome organisation and beyond
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evaluation of autism spectrum disorder in children with cerebral palsy easedcp
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cerebral palsy cp is the most common physical disability in childhood and autism spectrum disorder asd is one of its most common and impactful comorbidities proper identification of asd in cp is clinically important but stateoftheart diagnostic methods rely on behavioural symptoms that overlap with the motor and speech difficulties seen in cp this makes asd diagnosis very challenging and limits the validity and usability of standardized clinical instruments consequently some children with cp go undiagnosed and without important support for their asd others can be falsely diagnosed by for example being physically unable to complete assessments this has detrimental effects and results in resource misallocation easedcp will establish the nextgeneration goldstandard clinical tools for assessment of asd symptoms in cp current clinical and research practices for asd assessment in children with cp will be reviewed and experts surveyed consensus clinical guidelines and an adapted standardized instrument for asd assessment in cp will be codeveloped though a delphi process implemented and tested this will be enabled by a crosscultural international collaboration of pioneers in asd university of california san francisco outgoing phase cp university of barcelona return phase and instrument validation hogrefe tea ediciones placement my current clinical and research expertise in the psychological characteristics of children with cp interdisciplinary profile and previous success building international collaborations makes me the perfect fit to lead this project through easedcp i will connect with a broad international expert network and develop a unique collection of expertise this includes completing exceptionalquality training in testbuilding methods and asd assessments overall the cooperation of these leading research centres is expected to have a tremendous impact on the understanding and diagnosis of asd in cp
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uncovering the cortical cellular basis of specificity and chronicity of pain
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chronic pain remains a fundamental unsolved puzzle in biology and an unmet global challenge in clinical practice progress is limited by major gaps in knowledge on neural substrates owing to overwhelming redundancy of implicated regions and pathways with several painunrelated sensory cognitive and emotional functions as well as lack of understanding on the origins of plasticity and cellular substrates for diverse psychosocial and environmental influences on pain here we propose that neocortical neuronal ensembles ie discrete cohorts of coactive neurons intermingled within seemingly redundant pathways represent a mechanistic correlate for imparting specificity to pain perception while also providing adaptive flexibility to context and introspective bodily states and serve as convergent substrates for divergent influences such as past experience of pain fear memory and expectation using cuttingedge in vivo methods such as multiphoton imaging of activity and structure electrophysiological parallel recordings of hundreds of neurons finegrained behavioral analyses activitybased cell tagging approaches optochemogenetic manipulations and single cell transcriptomics in mouse models of acute and chronic pain we aim to i identify neocortical pain ensembles that delineate pain from other sensory percepts valence states and cognitive functions and determine their composition connectivity coordinated activity in local and across distant networks and functional relevance to pain ii study their dynamic plasticity over the transition from acute to chronic pain and delineate bottomup peripheralspinal and topdown brain intrinsic influences with a focus on studying the role of the salience network in channeling context expectation and fear memory and its dysfunction in chronic pain and iii study the potential of reversing plasticity of neuronal ensembles by noninvasive neurostimulation and behavioral approaches for achieving pain relief
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applying acoustic streaming to enhance mass transfer in liquid chromatography of large molecules
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liquid chromatography lc is a prominent analytical technique serving lifesciences chemical and pharmaceutical sciences which plays a key role in virtually all research and development concerned with liquid phase biochemistry the performance of pressuredriven lc has continuously increased during the past century with improvements realized by ordering the packing and reducing the particle size now that the point is reached where submicron ordered packings can be reliably produced the performance limitation of lc lies in the principle itself more precisely in the slow mass transport of analytes between the field lines with varying crosssectional poiseuille velocity vectors distribution of analytes in the sample bands over different local velocities results in tayloraris dispersion an effect that becomes increasingly important at high velocities or at low diffusion coefficients acolc addresses this lateral diffusion limitation by inducing acoustically generated lateral flows obtained in resonance mode the resulting vortices in this socalled acoustic streaming regime carry the analytes much faster than purely diffusive processes therewith reducing the dispersion dependency on size and mobile phase velocity while the efficacy of this acoustic vortex lc methodology has been recently shown in microfluidic channels in the host group the channel dimensions need to be scaled to the micronscale range with the resonance condition maintained in acolc innovative geometrical approaches will be pursued to overcome frequency limitations of commercial piezoceramic actuators improved separations of glycosylated hemoglobin variants are aimed for in glass substrates which are compatible with integrated uvvis absorption this improved separation application is of interest to millions of diabetes patients for routine separations and tackles an additional separation challenge encountered in multiethnic groups
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latestage photocatalytic functionalization of alkenes and 13dienes
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the latestage functionalization lsf of bioactive compounds is currently a hot topic in the chemistry community as it allows for the rapid and divergent construction of molecule complexity and avoids the need for timeconsuming de novo synthesis this is especially relevant in the fields of drug discovery and medicinal chemistry where the fast identification of structureactivity relationships is crucial especially intriguing in this context are alkenes and 13dienes as they are frequently occurring motifs in natural products and drug molecules including important antibiotics and antivirals however methods for the introduction of a broad variety of functional groups via the lsf of these moieties remain underdeveloped latefun aims to create new chemical space by developing a firstinclass methodology for the incorporation of a highly versatile functional handle via the lsf of alkenes and 13dienes whose wellestablished subsequent transformations will allow for the rapid assembly of diverse structures applying this innovative protocol to the lsf of complex natural products and drug molecules will be of great importance and impact going beyond the current state of art the reallife applications of this cuttingedge research proposal will be explored during a secondment phase in novartis basel providing for valuable industry insights and interdisciplinary aspects the hosts expertise in latestage functionalization of bioactive molecules using catalytically generated carbyne equivalents perfectly complements the applicants strong background in photocatalysis and therefore guarantees twowaytransfer of knowledge between the host group and the er experienced researcher the successful implementation of this action in the highly international and interdisciplinary environment of iciq and novartis will enable the fellow to develop a unique research profile and will be crucial in building an independent academic career
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improving lastkilometer navigation transportation of emergency personnel equipment and relief items in hazardous and challenging environments
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considering response operations and relevant tasks in an urban fire or wildfire performance of first and second responders is dramatically affected due to the low or even zero visibility conditionsforesight will design develop integrate deploy test evaluate and demonstrate a set of bespoke response tools and services at the service of civil protection agencies fire brigades civil protection organisations and emergency medical which ensures a catalytic upgrade when managing urban fire or wildfire these tools and services a effectively allow frs to see unobtrusively through fire smoke fog and dust b boost situational awareness tactical reconnaissance and lastkilometre logistics related not only to heavy equipment and emergency relief items delivery but also comprehending the entire route from start point of resources to entering and navigating to the hot zone c enhance decision and sense making of individual responders and teams from the onsite to the closure of an incident notably the tools and services delivered by foresight shall be evaluated against a rich technology inventory created within the project that extensively analyses existing technologies supporting first and second responders in their immediate response to natural disasters highlighting their strengths and weaknesses moreover the foresight technologies follow by design privacy ethical security and legal constraints to expedite their inclusion in response tasks and their abidance to standard operational procedures finally a rich integration testing and validation activities programme is followed of round tables rts technical integration workshop tiws component field tests cfts and system field tests sfts towards empowering collaborative response and handling of complex incidents to its fullest whilst facilitating implementation of most promising usercentred technologies in realworld conditions
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impact of spectrin mutations on the cytoskeleton and organelle organization in neurodegeneration
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spectrins are an integral part of the submembranous cytoskeleton providing both mechanical scaffolding and organization hub for other proteins in metazoan cells the importance of spectrins to neuronal health is demonstrated by their association with a wide range of human neurological disorders spectrinopathies currently more than forty mutations in the gene encoding nonerythroid spectrin sptan1 are associated with developmental and epileptic encephalopathies hereditary motor neuropathy hmn spastic paraplegia hsp and ataxia the underlying pathomechanisms remain largely unknown in drosophila the highly conserved spec homolog similarly plays an important role in the nervous system development as well as in synapse formation its function and maintenance interestingly synaptic defects associated with loss of spec can be suppressed via neuronal mitochondria repositioning conversely increased levels of spec rescue a range of neuronal phenotypes linked to actindependent mitochondrial dysfunction in an synuclein neurodegeneration drosophila model these findings suggest that modulating the levels of spec in neurons might have an important and understudied impact on tuning mitochondrial dynamics and preserving neuronal health thus the goal of my msca proposal is to deepen our knowledge on how neuronal actin and spectrin cytoskeleton regulate mitochondria and assess mitochondrial dysfunction at the basis of spectrinopathies with a combined use of drosophila as a model organism and human ipscderived neurons as a platform to translate the findings to human neuronal health and disease my project will provide insights on whether spectrinassociated mitochondrial dysfunction is a shared or specific feature for hmn hsp and ataxiaassociated spectrin mutants i will deploy these findings to tailor a pharmacological treatment in the spectrinopathy neuronal cellular models and develop a therapeutic strategy
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naturebased solutions education network
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the overall objective of nbs eduworld is to nurture an nbs literate society supporting a just transition to a sustainable future for this nbs eduworld will create an nbs community that facilitates synergies between nbs professionals and education providers and ensures free and easy access to nbs knowledge and resources for all to achieve this goal nbs eduworld will summarise the state of play of nbs education in europe and evaluate the initiatives already in place determine how to expand and replicate them and establish a basis and framework for the project itself and future initiatives resulting in guidance and policy recommendations in parallel the project will analyse nbs demonstrators with an educational dimension tier1 across europe nbs edusystems to support the testing and improvement of approaches and resources with nbs demonstrators with no or a limited educational dimension tier2 and create the means and opportunities for all nbs practitioners to engage with educators inter alia via tier3 nbs edusystems this will be done whilst supporting the overarching goal of promoting nbs as a viable career prospect for european citizens of all ages to adequately engage educators who are at different points on their nbs journey the project will provide specific activities for those who are not yet familiar with the concept and benefits of nbs and those already aware but in need of support to progress to the next stage these activities will be scaled upout by extensive dissemination and communication activities to maximise the projects outreach and ensure its longterm success only by joining with nbs experts education experts civil society supportive policies can we create an nbs eduworld a community that makes a difference
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repair mechanisms of topoisomerase ii dna lesions
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topoisomerase ii top2 chemotherapeutics such as etoposide have been widely used in the clinic to treat leukemias lymphomas lung testicular and ovarian cancers etoposide was first approved for clinical usage in 1983 by intercalating into dna etoposide stalls the top2 catalytic cycle generating toxic dna lesions known as top2dnaprotein crosslinks top2dpcs after 40 years of intense research the mechanisms employed by cells that counteract these lesions are starting to emerge these include enzymes that reverse the crosslink degrade the protein adduct or remove the lesion by dna incisions moreover the protein zatt was recently described as an essential regulatory enzyme that sumoylates top2 and thereby stimulates top2dpc resolution important and longstanding questions in the field relate to our understanding of how the different modes of repair are activated coordinated between one another and preferentially used by cells based on genetic data zatt appears to be the primary responder to top2dpcs but how zatt coordinates the different modes of repair via top2sumoylation is currently unclear to address these questions and study top2dpc repair we propose to use a novel approach based on xenopus egg extracts which can recapitulate dna repair mechanisms in a soluble environment as part of our preliminary data we show that these extracts can recapitulate top2dpc repair via zatt sumoylation providing a unique opportunity to delineate the molecular mechanisms underlying this reaction by combining this system with complementary and innovative approaches we seek to obtain a clear molecular understanding of the different mechanisms counteracting top2 lesions and unravel the molecular triggers that activate the different routes of repair by doing this we will provide new opportunities and targets to improve cancer treatment
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advancing phage therapy through synergistic strategies phagemediated killing and competitive exclusion using engineered prophages
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amid the antibiotic resistance crisis the centuryold practice of phage therapy the use of bacterial viruses to treat bacterial infections has gained renewed attention despite extensive research and clearcut advantages over antibiotics phage therapy has yet to gain momentum this is primarily due to remaining limitations eg the timeconsuming process of identifying suitable phages and limited in vivo efficacy with phagepro i propose a new technology to overcome the shortcomings of traditional phage therapy unlike the conventional use of lytic phages i will capitalize on prophages viruses that integrate into bacterial genomes capable of excision and replication by integrating prophages into safe carrier strains originating from probiotics i will unlock two pivotal benefits 1 rapid identification of suitable phages using advanced machine learning 2 sustained invivo efficacy yet the core advantage of phagepro lies in its unparalleled synergy of phage killing and pathogen competitive exclusion imposed by the probioticto realize this concept the development of predictive tools is essential to quickly identify the most promising prophages and probiotic combinations for each pathogen wp1 prophage engineering wp2 followed by rigorous in vitro testing will ensure a high safety and efficacy highthroughput in vivo experiments using wax moth larvae will reveal the most promising candidate which i will subsequently validate through a proof of principle experiment using a poultry model wp3although i initially tailored phagepro to treat salmonella infections in poultry its impact extends far beyond this new technology holds the potential for transformative changes in phage therapy not only advancing infection management in livestock farming through the enhancement of animal health and the assurance of food product safety but also by opening the door for targeted preventive and therapeutic interventions in human medicine
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transformative rotations for adaptation and sustainable future outcome and resilience mapping
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the vision of the horizonmiss2023clima0101 call is that europes regions will be responsible for their sustainable and resilient adaptation to climate change cc by developing roadmaps for adaptation of agriculture to cc these roadmaps will need to empower regional stakeholders to innovate new naturebased solutions that meet societys needs for cc adaptation through better planning that is compatible with national and international policy transform proposes that innovating new crop rotations the sequences of crops that farmers use to achieve their farming goals will deliver naturebased solutions for sustainable and resilient cc adaptation in arable and mixed farming working in the atlantic biogeographic region bioregion of europe we adopt an explicitly multiactor approach in which stakeholders are in charge of the innovation transform will cocreate with stakeholders tools and methods for regionallevel roadmaps that describe the needs for adaptation of local people in agriculture for farmers to innovate crop rotations for their region using the future rotations explorer tool and a toolbox of spatiotemporal methods and tools for stakeholders to explore and evaluate the societal economic and environmental indicators of impact of rotations when embedded within our social science methods these methods and tools will leverage an iterative pipeline to innovation for cc adaptation in agriculture that produces lists of acceptable crop rotations and maps for planning across the atlantic bioregion and ultimately the whole of europe this will allow the european commission eu member states and associated countries and their regions and stakeholders to make progress in attaining the goals of the eu mission adaptation to climate change
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universal data compression with circular context trees
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within the itul project funded by an erc consolidator grant we have developed a data compression algorithm based on circular context trees the proposed algorithm is universal in that it can compress any type of data the proposed compression algorithm offers unprecedented compression performance and shows an average of at least 82 improvement over commercial algorithms like lempelziv zip burrowswheeler transform compression bzip and more complex stateoftheart algorithms like prediction by partial matching ppm and context tree weighting ctw the proposed algorithm has linear decoding complexity the proposed poc is intended to extend the current binary implementation to arbitrary alphabets provide fast encoderdecoder implementation develop specific applications to compress satellite observation data and genomic data develop an indexed version of the compression algorithm in order to access some of the data without full decompression and investigate specific software licensing options and opportunities
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deep utube heat exchanger breakthrough combining laser and cryogenic gas for geothermal energy exploitation
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the future disruptive technology envisioned in deep utube heat exchanger breakthrough combining laser and cryogenics gas for geothermal energy exploitation deepu project is expected to revolutionize the deep geothermal energy sector the ultimate goal is to create a deep 4 km closedloop connection in the shape of a utube exchanger combining laser and cryogenic gas in a single technological drilling solution specific temperature control analysis and innovative laser lenses able to convey the heat and to sustain multilateral drilling will be developed alongside the utube creation guaranteeing liquefaction and vitrification of the rocks from ground surface to greater depths then a utube system ready to exchange heat with the underground becomes the main tool to exploit or store geothermal energy meeting energy needs in power and thermal energy production hence deepu project targets a novel and ambitious scienceto technology breakthrough in the field of geothermal exploitation the overall aim is the creation in laboratory of a vitrified waterproof noncracked utube exchanger for different kind of rocks this will be achieved by a laser drill head combined with special drill strings sustaining the coupled action of laser and cryogenic gas responsible for melting evaporating and cooling even the hardest rocks then i the physicalthermal phenomena affecting the rocks ii an evaluation of the legislative aspects and environmental standard related to the innovation proposed iii the modelling of the deepu geothermal exploitation potential considering some virtual case studies will be assessed the highrisk innovation proposed has the potential to make geothermal energy systems accessible anywhere in a targeted and demandoriented manner offering a complimentary approach and an alternative solution to traditional energy storage and production decentralizing the power supply also in areas where this is currently deemed uneconomic
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paleogenomic analysis of tuberculosis epidemiological histories over geocultural and ecological networks in south america
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tuberculosis tb the infectious disease produced by the mycobacterium tuberculosis complex mtbc remains one of the highestglobal disease burdens however the current body of knowledge on the mtbc is biased towards certain lineages particularly lineage 4 that spread from europe to the americas during colonial expansion recent advances in ancient dna research have the potential to broaden this picture with the recovery and analysis of whole genomes from strains that infected human populations in the past indeed these approaches have been recently used to identify ancient mtbc animal associated strains infecting humans in south american before the arrival of europeans analysis of these strains estimated that the mtbc most likely emerged during the neolithic approximately 6000 years ago much later than previously thought the pathogen project will seek to use these approaches to shed new light on the emergence diversity and spread of mtbc strains in the southern cone of the americas a neglected region concerning the epidemiological history of tb by employing ancient dna methods to examine and screen putatively positive tb infections of humans from archaeological and historic contexts of the current territory of argentina i will potentially provide genomic representation of tb histories over a broad time transect from precolonial populations to postcolonial cemeteries with these data i will perform phylogenomic and molecular clock analyses to investigate i changes in strain diversity over time in the region ii the historical and socioeconomical contexts that favoured the emergence and spread of the detected strains iii the emergence of genetic changes with potential clinical relevance identified in mtbc strains over the past centuries by offering a view of the past the pathogen project will increase our understanding of the diversity of mtbc across time and contribute a new perspective of the evolutionary and epidemiological histories of tb
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youth coproduction for sustainable engagement and empowerment in health
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most traditional youth mental health interventions fail to achieve sustainable impact at scale because they overly rely on individualized medical illnessfocused models and treat youth as passive beneficiaries citiesrise a multistakeholder initiative founded in 2017 to address these gaps has worked with youth communities and professionals across five cities as well as social innovators in over twenty countries to develop a set of evidencebased scalable youth mental health interventions and implementation models the yipee project aims to provide robust evidence on the feasibility adaptability effectiveness and costeffectiveness of a multicomponent intervention targeting the inner social and environmental dimensions that underpin mental health and broader ncd risk reduction outcomes when implemented using a youthinformed and activated approach this will be achieved through a a mixedmethods approach conducting a realist evaluation across the four sites chennai india nairobi kenya cape town south africa stockholm sweden to study key implementation outcomes following the practical robust implementation and sustainability model prism as well as the mechanisms underlying why the intervention works for whom and under what realworld conditions in chennai yipee will conduct a randomized controlled trial for more robust evaluation of effectiveness and costeffectiveness in achieving key mental health and other ncd related lifestyle behavioral outcomesyipee focuses on the combination of a schoolbased multicomponent intervention targeting positive disruption in the inner social and environmental dimensions of adolescents mental health and a youthinformed and activated implementation model that puts young people at the centre of transformation working collaboratively with a range of other stakeholders
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deciphering the role of host immunity in development of herpes virus meningitis
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viral infection remains a major health burden globally particularly considering the recent emerging viruses the reason why individuals differ in susceptibility to viral infection is an essential still unresolved question in infection immunology research the answer has strong impact on understanding of fundamental immunological principles as well as clinical medicinein this project we aim to identify novel inborn errors of immunity conferring increased susceptibility to recurrent lymphocytic mollarets meningitis caused by herpes simplex virus 2 by using advanced methodological approaches including whole exome sequencing genome editing and diseasemimicking model systems we will search for key mechanisms of importance for antiviral defense this project will provide new insights that can be translated into early genetic diagnosis prophylaxis and gene therapy and may pave the way for development of new antiviral therapies
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providing a digital and modular ecosystem for personalized capabilities development to enhance labour market participation and employment transition
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the main goal of diamond is to guide individuals from vulnerable socioeconomic backgrounds on their pathway to employment by tailoring learning programmes to individual needs and bolstering employability this is achieved by developing two unique solutions 1 the employability growth index egrow index a comprehensive taxonomy of individuals employability growth including their empowerment and transformative digital green capabilities objective 1 the egrow index will act as a measurement tool for classification and segmentation of user groups regarding the content and format of learning programmes 2 the modular and versatile platform for engagement and employability move a digital platform for lifelong learning with personcentered microcredentials and learning formats objective 2 on move individuals can grow their employability based on egrow and skill forecasts by participating in concise skill programmes recommended by an aisupported system to benchmark the impact breadth of the egrow index and move econometric costbenefit analyses and a stochastic lifecycle model are applied objective 3 the objectives are enabled by a vibrant research and innovation environment the grassroot living lab stateof the art social innovation experiments iterative research and stakeholder integrated cocreation will validate the diamond solutions diamond targets directly the main impact goals associated with the call the egrow index will help individuals to assess their employability growth and to empower them to selfmanage their skill development on move the increased engagement due to tailored learning programmes will facilitate an increased labour market participation the economic analyses and model provide an improved understanding of macroeconomic effects diamond contributes to inclusive growth reduced vulnerabilities and strengthened economic resilience due to its personcentered and datatechnology driven grassroot approach
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empowering the central and eastern european countries to develop circular bioeconomy strategies and action plans
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cee2act will empower countries in central eastern europe and beyond bulgaria croatia czech republic greece hungary poland romania serbia slovakia and slovenia cee2act target countries to develop circular bioeconomy strategies and action plans through knowledge transfer and innovative governance models enabling sustainability and resilience to achieve better informed decisionmaking processes societal engagement and innovation building on the practice of experienced countries serving as role models in this context austria germany the netherlands belgium spain finland sweden knowledge transfer and inspiration in creative formats that address the motivations needs and knowledge gaps of each cee2act target country will be realized through the cee2act national bioeconomy hubs a participatory nonpolitical bottomup approach will be applied throughout the project activities tackling specific knowledge gaps and shortcomings of the topdown conventional approach building closer interconnections between actors across public institutions private sector industry energy smes feedstock providers eg waste side streams farmers foresters fishermen academia and research ngos csos in the target countries to achieve this a baseline assessment will be carried out socioeconomic and environmental aspects stakeholder engagement activities will be implemented ensuring the proper involvement and active participation of all relevant stakeholders digital solutions for sustainable governance will be created exchange of knowhow and best practices on technology transfer building the capacities of the stakeholders to develop bioeconomy strategies the findings will be synthetized in an analytical framework which will result in nationallevel roadmaps for the bioeconomy strategies in targeted cee2act countries boosting societal engagement in the countries transition towards circular bioeconomy
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ultrafast control of magnetism with twisted plasmons
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harnessing twisted light light carrying orbital angular momentum on the nanoscale and its interaction with magnetism can revolutionize how we encode and process information in fact twisted electromagnetic fields can enable a superior control over the motion of the electrons and their spin compared to circularly polarized light yet a clear demonstration that it is possible to act on magnetism using twisted light has still to be established the main challenge is to find an approach to generate nanoscale electromagnetic fields carrying orbital angular momentum which can be exploited to drive magnetism with extreme few nanometers spatial resolution at the intrinsic time scale few tens of femtoseconds of the fundamental magnetic interactions exchange and spinorbit coupling responsible for the magnetic order in matter this feature is essential for the development of ultrafast optomagnetic applications in spintronics where a major goal is the coherent control of nanoscale magnetic bits in magnetictwist i tackle this challenge and propose the way towards nanoscale control of ultrafast magnetic phenomena by exploiting twisted plasmons that is plasmon polaritons lightinduced coherent collective oscillations of free electrons in metals carrying orbital angular momentum and driven by femtosecond light pulses this strategy will enable a coherent transfer of orbital angular momentum to the electronic spin and orbital degrees of freedom at the nanoscale in this way i will disclose new types of lightmatter interactions and new kinds of optomagnetic effects with a groundbreaking impact on ultrafast magnetism spintronics and lightdriven electronics beyond this magnetictwist will open a radically new path enabling to store and process an infinite amount of information on different spatiotemporal levels impacting also other research fields such as cryptography artificial intelligence and quantum technology
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affective polarization and democratic attitudes
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we currently witness democratic backsliding around the world where political rights civil liberties and free and fair elections are under assault at the same time politics in many countries are increasingly characterized by hostility and distrust across partisan lines a phenomenon called affective polarization could there be a causal link between the two despite several theoretical conjectures about how affective polarization erodes democracy through its negative effects on citizens democratic attitudes we lack the evidence to support them we also do not have reliable interventions to reduce affective polarization that are generalizable to different contextsdepolarize addresses these puzzles around affective polarization with two objectives first it will identify reliable and generalizable experimental interventions to reduce affective polarization in multiple contexts second it will establish any causal relationship between affective polarization and changes in democratic attitudes through novel empirical approachesdepolarize will achieve these goals by producing and analysing highquality observational and experimental data from multiple waves of surveys in hungary poland turkey and the us these countries are selected for analyses because they have recently experienced democratic backsliding to different degrees and they are also examples of high levels of affective polarization in societythe stakes for identifying factors contributing to democratic backsliding could not be any higher depolarize will contribute to this effort by establishing whether affective polarization is a factor driving democratic backsliding using stateoftheart causal inference methods depolarize is also one of the first projects in political science to employ comprehensive measures for cumulative learning coordinated and comparable randomized controlled trials in multiple contexts with preregistration of experimental interventions
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financing for green transition
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as the signals of an ecological and climate crisis are intensifying the surface temperature of our planet is already around 12c above pre industrial levels and is warming at an alarming rate against this researchers at the international panel on climate change ipcc share with us their assessments that meeting the 15c target is possible and yet it will require deep emissions reductions and rapid farreaching and unprecedented changes in all aspects of society the international energy agency calls to double the pace of energy efficiency progress towards green transition and notes that large scale financing mechanisms ought to be enacted often alluded as a tragedy of horizon climate change related risks had been regarded as the problems of long dure to be tackled by future generations leaving little motivation for the current cohorts but this is no longer the case as the urgency of the anthropogenic climate crisis becomes more explicit greening of the global financial system steps ahead in our agenda central banks being no exception in fact pathways to a net zero emissions global economy are relatively wellstudied and understood yet many of these studies focused mostly on green transition of the power sector and decarbonization of the industry while financing of this transition and particularly the potential role of the central banks is a relatively neglected area in the design of the green policy infrastructure thus there is clearly an unavoidable need to deepen our knowledge on the design of a green central bank that is in the words of dikau volz 2018 a central bank that takes environmental risks including climate change into consideration in its actions it is the purpose of this research consortium to study the potential of greening of the monetary policy instruments and set the stage for a new policy environment conducive to the struggle against climate change
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converting organic waste into sustainable biobased components
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waste2biocomp project aims to demonstrate relevant scale production of biobased products and materials as alternatives to traditional materials with high environmental footprint using innovative manufacturing technologies the project integrates all stages in the biobased products life cycle starting from ri activities regarding the sourcing of feedstocks for the development of biobased precursors and intermediate materials smart inkjet printing techniques and smart manufacturing technologies for final products and the final demonstrators which will entail the production on a relevant scale of the following biobased products shoe sole materials with different hardness threelayered shoe insoles plastic filmspackaging with different flexibilities social face masks fashion garments printed with biobased inks leather and textile shoes printed with biobased inks paper for packaging printed with biobased inks waste2biocomp will also develop sustainability and toxicity assessments to the developed materials and products as well as remanufacturing and recycling approaches to ensure circularity by closing the material loop furthermore the project will develop dedicated training activities to support the creation of a skilled workforce in biomaterialbased manufacturing sectors particularly for the textile footwear and packaging activitiestherefore waste2biocomp will have a significative impact on the reduction of the use of fossilbased materials not only in the approached three value chains textiles packaging and footwear which are highly resource and polluting intensive sectors but also with potential for several other sectors and applicationsthe project will run for 36 months and it will be constituted by 13 partners from france germany italy portugal spain and switzerland
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live biotherapeutics to potentiate cancer immunotherapy
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immunotherapy including immune checkpoint inhibitors icis has revolutionized the treatment of multiple cancers antitumor responses are often durable but overall only a subset of patients receiving icis has exhibited sustained tumor shrinkage whereas a substantial fraction receiving these therapies develops immunerelated adverse events the absence of dramatic responses is attributed to several factors including abnormalities in the tumor microenvironment tme specifically many tumors such as subsets of colorectal breast and pancreatic cancer become stiff as they grow tumor stiffening causes compression of intratumor blood vessels impairing blood flowperfusion and oxygen supply hypoperfusion reduces icis delivery to the tumor and hypoxia induces immunosuppression compromising immunotherapy to restore these abnormalities a novel therapeutic strategy to normalize tumor stiffness prior to icis has been tested in preclinical studies and in the clinic this strategy repurposes clinically approved drugs to target the factors contributing to tumor stiffening leading to a new class of therapeutics known as mechanotherapeutics however drugrepurposing poses certain limitations as adding a new drug to the treatment regimen of patients with cancer is not feasible in many cases as an alternative to these approaches we propose here to test the ability of engineered live biotherapeutics in the form of programmable bacteria that offer unique advantages for delivering enzymes to normalize the tme even a small fraction of bacterial dose reaching the tumor is sufficient to colonize it and allow therapeutic concentrations of tumorremodeling enzymes to be maintained for a long period of time we propose to evaluate the ability of a novel live biotherapeutic product to improve perfusion and potentiate icis in preclinical tumor models of colorectal and breast tumors this bacterial product has great potential for commercialization and a plan is proposed
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predict providing effective longitudinal models of ras direct inhibition to combat tumor resistance
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problemin 2022 more than half a million lung cancer patients worldwide carrying kras mutations faced therapy resistance a trend on the rise such cancers resist standard treatments and targeted therapies leading to an average survival of 12 years posttreatment the heterogeneous genetic background of krasdriven cancer adds further complexity hindering personalized treatment due to resistance unpredictabilitysolutionour proof of concept poc project predict provides a personalized treatment roadmap for krasmutant lung cancer available through knowledge and genetic tools generated thanks to our erc cog grant karma which was aimed at the understanding of the molecular mechanisms regulating the formation of the functional kras complex at the cell membrane using geneticallydefined krasmutant cell lines our lab can facilitate direct comparisons of rastargeted treatments including approved and trial drugs this effort will empower clinicians to recommend effective strategies based on a patients specific kras mutation accounting for initial and potential acquired mutations andor mechanisms of resistance the model will evolve through in vitro testing analyzing resistance mechanisms and predicting therapies based on the patients mutational landscape importantly our approach eliminates the need for animal models
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spatially resolved singlecell approaches in haematologic malignancies
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a global understanding of therapy response and therapy resistance in haematologic malignancies including multiple myeloma and acute lymphoblastic leukaemia in which cancerous cells accumulate in the bone marrow is still lacking this is due to the complex nature of the bone marrow therefore the goal of sesahme is to determine the difference of the bone marrow microenvironment in healthy individuals and patients suffering from multiple myeloma and acute lymphoblastic leukaemia this will help to understand under which conditions cancerous cells can accumulate and proliferate in the bone marrow which could lead to advanced immunotherapy approaches in the futureto achieve this the objectives of sesahme are to 1 establish a method that allows to determine the immune microenvironment composition in human formalinfixed paraffinembedded samples of the bone marrow which has the potential for highthroughput screening and being cost effective at the same time and 2 to use this method to characterise a healthy and dysfunctional bone marrow microenvironment that can contribute to multiple myelomaacute lymphoblastic leukaemia development and progressionsesahme will allow the fellow to independently carry out a project which will set the ground to build upon an own individual research profile to eventually become an independent researcher key transferable training will further improve the employability and career prospects of the fellow as well as increase the fellows communication abilities the host offers a multidisciplinary environment that is well connected with experts in the field enabling the fellow to develop a new mindset and approaches the fellow brings international and specialised wetlab experience that will facilitate knowledge exchange and increase ri capacity finally sesahme will increase the global attractiveness of the host via concrete dissemination activities
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community identity and diversity in german youth radio
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in times of increased mobility urbanisation and sociocultural tensions the way professional media as information providers and public watchdog present diversity has implications for social cohesion and for how young people perceive identity and society against this background youth radio stations which have become increasingly interactive and collaborative in the digital age are an important point of orientation for many young people living in ethnically and linguistically diverse spaces often struggling to fit in and looking for reliable information and guidance despite german broadcasters statutory and moral obligations to promote social cohesion and to contribute to building a nondiscriminatory society in germany the medias representations of ethnic diversity have frequently been criticised little is known however about what a meaningful engagement with diversity means for journalists and how they try to create social cohesion through their work through linguistic ethnography at a german youth radio station and a critical discourse analysis of media messages cidora will provide new insights into the linguistic and semiotic practices of radio content production to explore how journalists construct and negotiate a collective urban youth identity with their diverse audience and thereby try to create a sense of community in this context my project will shed light on possible issues that can lead to an unbalanced and negative portrayal of ethnic and linguistic diversity on youth radio to foster a more meaningful engagement of journalists with diversity by developing approaches for diversityoriented communication cidora responds to timely social concerns around difference and voice in a mobile world fraught with deepening division the results of my project will be disseminated through academic publications and outreach activities for journalists organised in collaboration with media stakeholders
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technological innovations in costume practice ticp enabling the adoption of new manufacturing technologies by live performance costume professionals
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the production of stage costumes relies on the talents and expertise of diverse costume professionals these practitioners employ a range of tools and technologies as they collaboratively work to convert an idea or 2d sketch into a 3d garment custommade for that character and show industry 40 manufacturing technologies such as virtual patternmaking and 3d printing offer substantial productivity financial sustainability and creativity benefits to costume construction but the adoption of such technologies is haphazard and obstructed by a perception that costume practice is not technically innovative this perception is informed by systematic gender biases that limit investment in and recognition of the skills and creativity of costume professionals who are predominantly female technological innovations in costume practice ticp is a research justice project that investigates the integration of technological innovations with the aim of facilitating their adoption and application in the work of costume makers this will elevate the field of costume production and strengthen the future employability of professional costumers the central research question driving the project is as costume practitioners implement new manufacturing technologies in their workflow what are the structural and attitudinal factors that constrain and facilitate their adoption through a groundbreaking crossdisciplinary approach that applies theories about sociotechnical change to data from practitioner interviews and digital ethnography the project will develop a model of technological adoption for costume that responds to the very specific context of the live performance industry such a model will enable practitioners to be more deliberate effective and empowered when engaging with new manufacturing technologies the project results will centre the feminised area of costume at the cutting edge of a currently very malegendered technical production research discourse
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digital agriculture and forestry understanding the market to forecast and support future growth
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4growth aims to contribute to the uptake of digital and datadriven solutions in agriculture and forestry by i documenting the current stateofplay and projecting the future evolution forecasting and foresight of the sector ii making insights available to the wider community of decision makers and value chain actors through the 4growth visualisation platform iii collecting a wide range of ground truth data and identifying key factors or constraints for uptake and iv producing sets of key policy recommendations and best practices to encouragefacilitate further uptake to successfully fulfill its ambition and carry out the proposed activities 4growth brings together a highlymotivated team of 13 partners from 9 eu member states with strong proposition and extensive involvement in digital agriculture and forestry activities
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making timeresolved cryoem available for the community of structural biologists validate improve derisk
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knowledge of protein structure is fundamental for the understanding of biology disease mechanisms drug development and biotechnology recent progress with electron cryogenic microscopy cryoem simplified and tremendously accelerated the determination of protein structures including multiple protein conformations many functionally important protein conformations and proteinprotein complexes are transient and are not easily accessible by conventional cryoem these transient states can however be freezetrapped and their structures solved to high resolution using the timeresolved cryoem trem despite its long history and high interest from the cryoem community technical difficulties prevented the spread of the methodology and no commercial devices enabling trem sample preparation exists during the erccog project we developed a new approach to the preparation of trem samples which has advantages over the other reported technologies in this poc project we propose to undertake steps that will explore the suitability of our technology for application to a wide variety of protein samples and to evaluate the commercial potential of the technology with aim of bringing it to cryoem users rapidly to achieve this we plan to 1 expand the number of protein samples to be tested on our instrument thus enabling rapid user access and simultaneous validation of the methodology 2 perform additional research to further improve the method by addressing the remaining bottlenecks 3 make steps towards defining the best process and materials for industrial production of microfluidic chips and 4 redesign the timeresolved plunger into a compact preindustrial prototype these steps will broadly validate improve and derisk the technology to make it more attractive to cryoem instrumentationmaking companies to bring the technology to the cryoem community
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nanofluidic chips for reproducible cryoem sample preparation with picoliter sample volumes
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cryogenic transmission electron microscopy cryoem is a technique for highresolution imaging of radiationsensitive biological macromolecules under nearnative conditions cryoem sample preparation techniques rely on rapid cooling of an aqueous suspension of biological macromolecules to obtain a thin layer of amorphous ice containing the solute problems associated with current implementations are considered a major bottleneck to realizing the full potential of cryoem excessive sample consumption the difficulty to reproducibly obtain ice conditions suitable for highresolution imaging and the extensive contact of solute molecules with a large airwater interface result in only a small fraction of the imaged molecules contributing useful information for the final 3d reconstruction poor time resolution of these methods furthermore precludes the visualization of dynamic structural changes that provide critical biological insight in our laboratory we have developed technology to design nanofluidic mems devices suitable for cryoem imaging we here propose to explore product development of a nanofluidic chip for reproducible sample preparation with picoliter volumes the sample is contained in nanochannels formed between membranes of an electrontransparent material thereby controlling ice thickness and avoiding formation of an airwaterinterface this method has all features to push cryoem to new frontiers it requires minute amounts of sample robustly provides uniform and customizable thickness gradients across the sampling area at a time resolution that is limited only by the vitrification process itself our cryochip will provide entirely new opportunities for timeresolved cryoem imaging and highthroughput applications in structurebased drug design for pharmaceutical industry we will liaise with an industrial partner experienced in mems probe fabrication to explore processoptimization and viability of largerscale production
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climate change and air contamination artificial intelligence applied on the correlation between air pollutants and noncommunicable respiratory diseases in europe
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the climair project will expand the evidencebased understanding of climate change air pollution and noncommunicable respiratory diseases by using artificial intelligence ai tools it will gather data on greenhouse gases levels and disaster risks information on serious air pollutants and respiratory diseases prevalence the aipowered tools will be employed to generate better intervention methods and improve public health outcomes federated learning fl will be used to develop ai models to protect patients privacy by raising public awareness and delivering the climair tool specifically designed to health workers urban planners and policy makers the project aims to influence policy decisions promote healthier environments and reduce respiratory diseases in europe which will be tested and validated the climair tool in specific municipalities that are part of the project climair draws on a consortium of 21 partners from 15 european countries including carefully selected health centres across europe in spain luxembourg ukraine italy france germany greece romania and poland focused on respiratory diseases which will provide disease data and explore metabolic routes of the studied contaminantsdiseases climair is composed of an interdisciplinary team formed by research centres ethical ai and modelling experts ssh specialists municipal governance and a communication dissemination cd expert team dedicated to achieving and spread the results of the project
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new foundations for realworld cryptography
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almost half a century after the invention of publickey cryptography there is still a vast discrepancy betweenthe theory and practice of cryptography with some notable exceptions research from the cryptographic theorycommunity focuses on problems of great theoretical interest albeit completely disconnected from the real world on the other hand widely used realworld cryptographic protocols are being neglected because they are either mathematically ugly their solutions appear uninteresting or they simply do not cross the mind of theoreticians the current state can be summarized as follows several wellestablished theoretical cryptographic concepts fall short from properly modeling the way practitioners think about realworld cryptography there exists a surprisingly large amount of modern cryptographic primitives and standards with unclear provable security statusthe central objective of the reworc project is thus to narrow the gap between theory and practice of cryptography providing a solid theoretical groundwork for realworld cryptography to this end we will lay a new theoretical foundation for realworld cryptography in the elliptic curve setting develop new tools and models for the design and analysis of practical cryptography in the postquantum setting revisit the concrete security of legacy cryptography from the 2000s recently established standards and forthcoming standardsreworc will have a substantial longterm impact on theoretical protocol design influence ongoing standardizationefforts in postquantum cryptography and settle doubts about the security of important cryptographyused in practice
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centre for digitalisation of biology towards the nextgeneration of biosustainable products
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biosustainablility is an important goal for humanity as it addresses many global challenges we face we need convergence of different technologies and domains to tackle challenges of biosustainability and combination of digitalisation and biotechnology provides a powerful opportunity for this while engineering of biology has delivered sustainable products highthroughput generation of biological data has outpaced our capacity to learn from it digitalisation of biology however through exhaustive analysis of big data using integrated informatics approaches promises to deliver nextgeneration bioengineering solutions towards a green economy these range from healthcare to biomaterials new foods and sustainable energy to foster digitalisation of biology we propose a teaming partnership between the novo nordisk foundation centre for biosustainability at the technical university of denmark dtu and the estonian centre for biosustainability ecb that links leading universities of estonia university of tartu and tallinn university of technology the digibio project will significantly upgrade the ecb and will create a research and technology platform for datadriven disruptive bioengineering solutions to accelerate translation of science to manufacturing of nextgeneration bioproducts the platform relies on complementary actions of partners for the generation and analysis of big data through integration of automated genome engineering phenotype screening highthroughput analytics and informatics it combines knowledge and techtransfer of a unique concept for digitalisation of biology and personnel training developed by dtu to ecb a bioengineering hub of estonia and the success story of it commercialisation and competence of estonia the project is aligned with the focus and smart specialisation areas of estonia and aims to enhance regional development by extending the biosustainable research and industrial practices of denmark into the baltic region
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aibased leukemia detection in routine diagnostic blood smear data
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acute promyelocytic leukemia is an extremely aggressive blood cancer where immediate diagnosis can determine life or death the diagnostic state of the art is manual inspection of a patients blood smear under the microscope by trained cytologists it is prone to human error and time consuming a risk factor in notoriously understaffed laboratories supporting clinical decisions with ai will drastically increase diagnostic speed and accuracy benefit patient survival and free up valuable expert time this is particularly important for cytological and histological analysis whose market size is expected to rise by a compounded annual growth rate of 147 in coming years yet so far the proof of concept that ai can be effectively employed for leukemia detection in routine diagnostics is missingi will leverage the methodological advancements in deep learning and explainable ai the skills of my erc cog funded research group and the expertise and data of the munich leukemia laboratory mll the largest leukemia laboratory in europe and my long standing industry partner together we will develop and implement leukoscreen an aibased software to automatically identify and flag up acute leukemia cases from mlls routine laboratory input this will decrease the diagnosis to treatment time of critical leukemia cases at reduced costs and staffing specifically we will i deploy a realworld dataset from the routine input of the mll ii train and evaluate our algorithm for transparent decision making on routine diagnostic blood smears iii quantify the gain in sensitivity specificity and speed by comparing leukoscreen with the currently used manual workflow at mll and iv jointly develop a commercialization strategy for the exploitation of resultsthis ai approach to support disease detection will save patients lives change the paradigm of cytologic workflows and create capacities in overburdened diagnostics
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orthopaedic treatment with allogenic combined atmp in long bone fracture delayed union and nonunion orthoallounion
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bone fracture with delay or failure to heal is a condition with huge health impact although only a small proportion of long bone fractures evolve to nonunion 5 it is a first magnitude problem due to the number of new annual fractures and increasing incidence of complex fractures with high risk of nonconsolidation need for repeated procedures and years of patient disability bone autografts autologous mesenchymal cells or other complex interventions are used in this setting the aim of this project is the development of a universal therapy for fractures with delay or failure to heal aiming to a simple and wide access to allogenic cell therapy combined with biomaterial in a broad number of patients rather than considering atmp only as a last solution in established nonunion fractures this project advocates that the indication should be moved to an earlier timepoint patients will be treated with the combined atmp as soon as the need for reoperation is identified due to delayed healing with or without an added infectious component to avoid longterm suffering for patients and their relatives and prevent progression to more severe nonunions with heavy personal social and economic costs this approach is aligned with the real needs of patients and better fits with the usual practice in the eu where reoperations are performed at 6 months or before in an attempt to accelerate bone healing and avoid complications the project will establish a master cell bank for a wide allogenic production with donors selection criteria of bone formation potential necessary preclinical and clinical information to support the eu approval of a specific combined atmp will be obtained open access to scientific and regulatory information will be available for other eu medical device companies and cell therapy producers so in addition to direct clinical benefit to patients and healthcare providers other developers of combined atmp products will get benefit
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enabling environmental mycotechnologies
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enabling environmental mycotechnologies eemeem aims at developing soil fungal based remediation solutions to a commercial scale indeed emerging fungalbased approaches have been proposed as attractive options for the biological treatment of polluted matrices such as soil sludge sediments and water such mycotechnological approaches also offer an exciting potential for the restoration of degraded ecosystems mycoremediation and mycorestoration as they have the potential to foster the adoption of low carbon sustainable solutions in many industrial fields such as agricultural biologicals biostimulants biopesticides etc mycomaterials production of enzymes for the industrial sector products for the agrifood industry the specific objectives of eem aresecuring novobioms core ip assets as one proprietary dynamic knowledge repository this will be achieved by establishing a tailored fungal database for environmental applicationssetting novobioms strategic roadmap for the protection diversification and scaling of all foreseen fungal applications
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biomicauth center of excellence in metabolomics research
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biacem aims to link biomicautbiacem aims to link biomicauth an interdisciplinary laboratory of the aristotle university thessaloniki with three world leading metabolomics research groups the bioinformatics team of imperial college london the metabolomicslipidomics research team fundacin universitaria san pablo ceu madrid and hmgu via the realization of the project strategic partnership and networking will be developed promoting the research status and capacity of biomic researchers and covering existing gaps in knowhow and technology long term aim of biomic is to lead develop new concepts analytical methods and ways to produce or analyze comprehensive datasets furthering the application of metabolomics in life science and biomarker discovery to reach this level existing pinch points should be addressed themes identified as strengths of the advanced partners and key areas of biomic improvement include development and organisation of lipidomics experimentation in lcms exploitation of advanced mass spectrometry acquisition and ion mobility spectrometry data metabolite identification effective mining and use of multiple data sets data management artificial intelligence tools for metabolomics data and for text mining natural language processing data fusion effective biochemical interpretation transfer of knowledge is organised as a series of training events webinars emeetings staff exchanges and collaborative research with the advanced partners emphasis is also put on training on research management and setting a research management unit in biomic three clinical biomarker discovery demonstration projects constitute the research element of biacem realization of the project will have major impact on biomic their collaborators and the greek metabolomics ecosystem as it will remedy weaknesses and provide new timely and necessary technological solutions for the first time to greek scientists promoting level or research and innovation
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