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ocean night helping society understand the importance of the marine ecosystem
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life started in the oceans oceans cover the majority of earths surface and are the single largest ecosystem on the planet billions of humans live in coastal areas and depend on the functioning of this ecosystem to live unfortunately human activities are seriously endangering the health of the marine ecosystem it is therefore critical to raise awareness of the richness of this ecosystem its importance the challenges it faces and what we as citizens of the world can do to improve and preserve it through our personal choices with the mcsa researchers night proposal ocean night we aim to contribute to this challenge by raising marine science literacy across the general population and promoting the appreciation of the importance of the marine ecosystem our proposal brings together all public research institutes across spain working on marine science for a comprehensive 2years outreach program we will leverage the substantial outreach experience of the institutes to deliver a diverse and coherent program of events aimed at engaging a geographically wide and socially diverse set of regions within spain
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innovative minimally invasive device to support the natural movement of the heart in heart failure patients
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syntach cs is a groundbreaking lifesaving device for longterm cardiac support that restores the natural function of the hearts mitral plane movement in patients suffering from left ventricular heart failure the technology is based on recent findings of the physiological movement of the intact heart which pumps with a scooping longitudinal movement of the mitral valve in heart failure this movement is impaired and the heart is unable to pump enough blood to meet the metabolic needs of the body syntach cs works in synchronization with the heart supports the cardiac movements and reestablishes a natural healthy movement it is fully implantable in a minimally invasive procedure heart movement support is enabled thanks to a mitral anchor ring connected to a drive unit implanted in the lower apex region of the heart from which a pulsatile movement is transferred to the mitral plane the system is recharged and monitored wirelessly with no elements protruding through the skin
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symbiotic interactions at the origin of eukaryotes
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recent advances in environmental microbiology metagenomics and phylogenomics strongly suggest that the eukaryotic cell evolved from symbiotic consortia involving an asgard archaeon and at least the alphaproteobacterial ancestor of the mitochondrion however many genes of prokaryotic origin in the last eukaryotic common ancestor leca appear to originate neither from archaea nor alphaproteobacteria suggesting that other bacteria eg deltaproteobacteria may have contributed to eukaryogenesis as additional symbionts or gene donors to ascertain the origin of these genes it is essential to better understand the ecology of symbiotic microbial consortia involving asgard archaea aa and in particular to identify the partners with which they interact in natural ecosystems in this project i will combine metagenomics phylogenomics fluorescenceactivated singlecellconsortium sorting highthroughput microfluidics stateoftheart fluorescence and electron microscopy techniques and cultivation approaches to identify and characterize members of aa syntrophic consortia and their associated viruses in a broad variety of microbial mats and oxygenpoor environments with this information i aim to i identify the partners of aa syntrophic consortia across ecosystems determine whether they coevolve and unravel their ecological preferences ii characterize the metabolic interactions and phenotypic properties of aa symbiotic consortia in culture andor from sorted consortia populations iii characterize the cell ultrastructure and potential presence of endomembranes in members of aa consortia their threedimensional organization and their spatial distribution in microbial mats and iv identify potential bacterial symbiotic partners involved in eukaryogenesis in addition to the mitochondrial alphaproteobacterial ancestor andor gene donors to the leca or its asgard archaeal ancestor our results should substantially advance understanding of eukaryogenesis
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young international academics postdoctoral programme
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the young international academics postdoctoral programme yia is a career development program proposed by the university of luxembourg unilu to nurture earlycareer postdoctoral applicants to gain momentum in interdisciplinaryintersectoral research yia applicants are international talents willing to propose and realize their own interdisciplinary research projects through a bottomsup approach yia will welcome in two calls a total of 10 postdoctoral fellows with 36month contracts over 5 years yia is open to all disciplines and sectors involving unilu in the drive towards an increased interdisciplinarity and intersectorality which are strategic for unilu for the country and for europe a unique aspect of yia is its integration into unilus institute for advanced studiesluxembourg ias created in 2019 to promote interdisciplinarity and outreach towards the society this integration provides the yia fellows with 1 a supervision for interdisciplinary and intersectoral research with more than 350 potential cosupervisors and with about 350 potential publicprivate partners 2 peer and crossgenerational interactionsmentoring through the ias fellows invited distinguished senior scientists early career researchers and a mandatory academic or industrial secondment and 3 a truly international flavour in an environment that cherishes diversity and excellence yia fellows recruited at unilu are offered competitive contracts with mobility fellowships and access to excellent research infrastructures a professor of unilu provides supervision for the primary discipline of the applicants project and a cosupervisor covers the complementary disciplinesector the yia fellows are offered an la carte training including mandatory courses to suits the fellows career aspirations increase the fellows interdisciplinarity and employability the yia programme will support a rapid ramp into a longterm unilu funding of postdoctoral ias fellows
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horizon europe office in ukraine as the key national contact point ncp
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the agreement with ukraine associating it to horizon europe and euratom rt programmes has been in force since 9 june 2022 and represents a key instrument to support ukrainian researchers and innovators in the context of ongoing military aggression by russia ukrainian entities can participate in the programmes on equal terms with entities from eu member states ukraine does not have to contribute financially for years 2021 and 2022 and there is a general encouragement across the horizon europe work programme to create opportunities where possible for the affected persons and entities of ukraine at the same time ukraines ri capacity both at institutional and individual levels is at risk in view of public ri budget cuts and destroyed research infrastructure according to the latest survey out of more than 2000 ukrainian scientists 38 have been forced to relocate internally 15 have left abroad and three quarters are struggling to carry on their workin relation to other associated countries horizon europe offices exist in georgia executive agency of the ministry and turkey the scientific and technological research council tubitak and represent useful tools to facilitate andor improve these countries in the horizon europe programme a grant to identified beneficiary is an appropriate implementation modality for this action as it will reinforce the key ri public institution of ukraine the national research foundation of ukraine nrfu in view of the ongoing military aggression by russia and its farreaching impacts on the ri sector in ukraine the nrfu is the only public institution that runs competitive rd calls in ukraine
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artificial intelligenceenabled microfluidic analysis of ciliary beat defects for drug discovery biomedicine and disease screening
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in ai4cilia artificial intelligence for cilia we will develop an automated microfluidic aipowered assay of ciliated cells to detect and classify ciliary beat abnormalities for drug discovery biomedicine and disease screening rhythmically beating ciliated cells perform important physiological functions in the airways and the reproductive system defects of ciliary beat contribute to debilitating diseases such as todate uncurable chronic obstructive pulmonary disease copd and underdiagnosed causes of infertility in the context of our erc stg meccopd we recently showed that standard videomicroscopy recordings of ciliary beat can be used to extract quantitative metrics that clearly identify diseasespecific ciliary dysfunction therefore since ciliary beat can be observed in vitro and in minimally invasive biopsies it could provide a muchneeded readout for drug development and improved diagnosis however since ciliary beat patterns are highly complex it takes specialists to analyze them and hence this information is rarely exploited in praxis to establish ciliary beat as a common readout we developed a microfluidic platform that standardizes data acquisition from ciliated cells and uses ai for detecting and classifying ciliary beat defects to bring this approach to the next level and towards market entry we will address three key objectives in ai4cilia to demonstrate 1 hardware feasibility by validating human ciliated cell capture and data acquisition in our microfluidic chip 2 software feasibility by training our ai algorithm to detect diseasespecific ciliary defects and validate sensitivity and specificity of our assay and 3 business feasibility by assessing customer needs in biomedical and clinical research to define the most efficient gotomarket strategy we believe this strategy will make ciliary beat a highly sensitive and robust readout for respiratory and reproductive dysfunction in biomedical and clinical research
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consortium for developing regulatory capacity for clinical trials using gene therapy products and strengthening pharmacovigilance in the conduct of clinical trials in east africa
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gene therapy advancements have shown promise in treating chronic conditions like hiv and sickle cell anaemia and have the potential to greatly reduce the burden of disease in subsaharan africa which is plagued with a double burden of communicable and noncommunicable diseases these treatments have the potential to reduce the burden of disease for the populations for which they are targeted and the cost of treatments for governments in subsaharan africa there are largely no or unclear regulatory frameworks for clinical trials using gene therapy products as pioneers setting up frameworks for regulatory oversight of clinical trials using gene and cellbased therapy products uganda and tanzania will be able to share this knowledge through regional platforms to support other countries in the region to put in place similar regulatory frameworks additionally researcher workshops and course developed on gene therapy products will build capacity among researcher regulators and the publicpharmacovigilance in clinical trials for safety of trial participants and to accurately characterize the safety profile of the drug for the targeted patient population safety monitoring in clinical trials in the region currently faces challenges associated with health system challenges investigator awareness poverty and limited access to diagnostic tools additionally there is limited investigator awareness of of their responsibility to the patients with regard to monitoring and treating and accurate reporting of serious adverse events during clinical trials the results of this project will also provide a basis to sensitize investigatorssponsors and engage policymakers on the requisite health systems reforms to create a safe environment for the conduct of clinical trials with the ultimate goal of accelerating research registration and access to these new medicine technologies
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against prostheses abandonment immersive and lowcost platform for the rehabilitation of upperlimb amputees
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up to 44 is the abandonment rate of upperlimb prostheses the lack of training and rehabilitation is among the reasons underlying the high rejection rate when available traditional treatments lead to ineffective results because they are repetitive tedious and discouraging when considering the eu investments in prosthetic development 1735 million period 20192022 and the costs granted by the national health system for assistance this problem gets worse brainmade proposes a paradigm shift to change the current situation within the ercfunded handmade project we exploit the idea that natural hand usage shapes behavior and brain activity we reinforced the conviction that longterm continuous specialized training is prodromal for prosthesis acceptance by integrating virtual reality vr scenarios controlled by electromyographic emg activity in upperlimb amputees our experimental data on a 4week long motor training show high motor performance and embodiment even of nonanthropomorphic prosthesis eg tweezers beyond being highly specialized as it contains the hand degrees of freedom we realized that this virtual bionic tool simplifies action intention and execution by exploiting motor properties hardwired in the brain thus the difficult transition toward prosthesis acceptance may imply a progressive acquisition of new motor skills and adopting brainmade prosthetic devices built on an individuals expertise and neural resources the proposed motor training protocol also integrates fullycustomized inkjetprinted and lowcost emg sensors designed on the patients stump and residual muscle activity and daily monitoring of the motor performance those data will serve prosthesis fabrication and feed freelyavailable databases for developers in the rd sectors of upperlimb prostheses with the ultimate project goal of reducing prosthesis abandonment our idea can significantly impact amputees lives and transform rehabilitation practice
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the gibbs framework for nearterm quantum computing
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the gifneq project one of the major bottlenecks in quantum computing noise an umbrella term for various imperfections affecting the device the initiative establishes a unified theoretical framework focusing on two primary goals developing scalable noise characterization techniques and crafting verifiable quantum algorithms resilient to substantial noise levels a particular focus is placed on revolutionizing dissipative preparation schemesa subset of quantum algorithms analogous to metropolis samplingaiming to make them a preferred state preparation method by creating noiseaware verifiable algorithms requiring considerably less quantum error correction a resourceintensive element in quantum computingsimultaneously gifneq endeavors to radically simplify and augment the reliability of the traditionally complex noise characterization process it leans on recent breakthroughs in robust learning theory to discern and detail structured noise sources efficiently introducing protocols resilient to anomalies ensures robust and reliable learning of quantum noise these objectives are intertwined by the requisite mathematical framework heavily contingent upon quantum gibbs states a quantum extension of markov random fields with the project also seeking to obtain various mathematical statements related to these statesgifneq promises to be a watershed in quantum computing targeting practical resolutions with profound theoretical insights and bridging domains like quantum information computer science and mathematical physics to pave the way for breakthroughs that reshape the effective utilization of quantum devices as a seasoned expert in the field with a wealth of knowledge on noise impact characterization and quantum dissipation in quantum computation substantiated by publications in renowned journals such as nature physics or nature communications i present a uniquely qualified leadership to steer this transformative project
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next generation ketoamide inhibitors of fibroblast activation protein fap to revolutionize radionuclide therapy in cancer
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fibroblast activation protein fap is a serine protease that is highly expressed on cancerassociatedfibroblasts cafs in nearly all tumor types its limited presence in healthy tissues makes it an attractive diagnostic and therapeutic biomarker for cancer uamc1110 a potent and specific fap inhibitor discovered by the host opened the way for the development of the socalled fapis these are tumortargeting molecules composed of a uamc1110 moiety and a radionuclide the latter can either be a diagnostic radionuclide for pet imaging or a more cytotoxic radionuclide for cancer therapy radiodiagnostic fapis are now entering clinical practice but their therapeutic counterparts face challenges related to the relatively short tumor residence time of currently available molecules the latter leads to significant leaking of toxic radioactivity from the tumor to overcome this issue we will develop ketofapis that form longlived covalent bonds with fap this should already ensure significantly longer tumor residence the ketofapis will also be bound to the surface of gold nanoparticles aunps the resulting constructs could have further increased tumor residence through the multivalency effect this interdisciplinary proposal covers 1 the chemical preparation of novel ketofapis and derived aunps 2 their in vitro characterization and 3 in vivo investigation in a mouse model of colorectal cancer overall the project can lead to safer and more efficient fapis for radiotherapy applications the status of fap as a pancancer biomarker entails that these fapis could be applied in nearly all cancer types
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predicting fracture in 3d printed concrete beam lattice systems with the quasicontinuum method for computational efficiency
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3dprinted concrete 3dpc mitigates co2 emissions provides architectural design with higher degrees of freedom and decreases both labor costs and energy consumption however its layerbylayer buildup process results in weaker and more porous interlayers thereby significantly decreasing the integrity and durability of 3dpc structures and limiting the versatility of this technology to overcome this major drawback fraqcon aims to develop a computationally efficient framework to understand how porosity affects interlayer bond strength and to enhance 3dpc for this purpose fraqcon will apply numerical beam lattice models to 3dpc because they accurately predict fracture in heterogeneous materials such as concrete and rock although microscale porosity analysis based on simulations of engineeringsized 3dpc structures remains computationally unfeasible the multiscale quasicontinuum qc method has efficiently reduced computational costs for lattice systems its current form is not yet applicable to 3dpc beam lattices but fraqcon will develop a novel qc methodology for fracture in 3dpc beam lattice models to predict failure in a computationally feasible way while accounting for porosity on a microscale and accurately representing the complex air void morphology in 3dpc interlayers moreover this qc methodology will be validated with experimental tests by identifying key parameters that cause interlayer weakness fraqcon will significantly improve 3dpc technologies and increase the integrity safety and durability of 3dpc structures the fraqcon qc framework and the knowledge gained during this project will be transferred to a 3dpc startup in a nonacademic placement to accelerate the adoption and foster the market impact of this technology therefore fraqcon will not only demonstrate the applicability of the qc method for 3dpc design but may also transform the construction sector towards automation
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electric vehicles fire risk assessment in indoor car parks
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the sales share of electric vehicles ev in europe rose to 10 in 2020 as compared to 32 in 2019 this trend is projected to increase to 19 in 2025 and 35 in 2030 this positive trend comes with the safety risk and hazards associated with evs the current immediate need of research must be concentrated for indoor car parks due to its comparatively higher risk than any other open spaces to date there is no specific study on ev fire safety in car parks which is concerning given that the number of ev fleets are growing at a rapid pace in europe with past incidents of burning ev vehicles related to the charging process as well as with the ongoing battery fire safety issues there is an urgent need to explore in detail within the topic of ev fire safety in car parks recent searches from building codes from germany netherlands norway spain and austria have concluded that there are no specific fire safety design regulations for evs in car parks responding to this research and policy gap this interdisciplinary project aims to develop a stateoftheart risk assessment model that can be used to quantitatively measure the risk of ev fire in indoor car parks to achieve the aim two main objectives have to be fulfilled o1 to establish a qualitative and quantitative fire risk assessment model that can be used to measure risk level of specific car park design o2 to propose prevention and mitigation measures in a selected architectural design of car parks to accomplish the objectives activities such engagements assessments and simulation work are planned within the 5 work packages proposed in the project the output from the assessment can be used to develop specific prevention and mitigation measures for specific car park design that can lead to minimization of the impact of ev fire the model can also be used as a baseline to develop a policy or regulation for authorities having jurisdiction
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selfhealing screenprinted perovskite photovoltaics beyond shockleyqueisser limit
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due to environmental benefits scalability competitive cost and limited maintenance photovoltaic pv systems are the fastestgrowing renewable energy technology enabling largescale carbonfree electricity production within the family of pv systems metal halide perovskite mhps solar cells are the most performant at converting sunlight to electricity due to their excellent optoelectronic properties and cheap fabrication process mhp based on hybrid organicinorganic lead halides are the most effective perovskite solar cells yet there are two major challenges to widespread adoption of lead based lhp pv i instability especially against moisture and ii high level of lead pb and lead leakage which are toxic to humans and wildlife according to eus restriction of hazardous substances rohs directive this proposal will develop for the firsttime perovskite photovoltaics with selfhealing capabilities while decreasing lead leakage to near zero by transferring the microconcentrator pv concept to mhp such a configuration enables to save 90 to 99 raw materials compared to a planar device more importantly it increases the theorical efficiency and reduces the pb content and leakage so the main goal of this proposal is to boost the stability of lead halide perovskite pv systems by introducing microconentrator pv concept and concentrated light to mhp in addition to taking advantages of microconcentrator pv ie physical separation and embedding of each microcell to enable the pv system to theoretically exceed the shockleyqueisser limit and reduce toxic lead levels to below rohs requirements sherpas achievements will make advancements on cutting edge mhp solar cells that are pivotal to reach eus environmental targets for a reliable and green energy transition at lowcost
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euroheartpath leading innovation in cardiovascular pathways for improved patient outcomes
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cardiovascular diseases cvd present a significant public health challenge throughout europe being the leading cause of morbidity and a major contributor to mortality despite technological advancements and preventative strategies the burden of cvd remains substantial and the cardiac care pathways across europe are inadequately mapped the overarching goal of the euroheartpath consortium is to transform cardiovascular care pathways across the continuum of care by adopting a paneuropean scope and facilitating crosscountry comparisons euroheartpath aims to elucidate how care is organized and delivered providing deeper insights and identifying best practices for integration with the support of stakeholders including esc wonca eupha and epaeuroheartpath will simultaneously conduct 18 pathfinder studies to optimize the personalized early detection diagnosis monitoring and treatment of heart failure atrial fibrillation ventricular fibrillation and coronary disease with a particular emphasis on prevention these studies are categorized into four key areas 1 novel artificial intelligence ai and machine learning applications such as automated ai analysis of ecgs and holters and ai for predicting cardiomyopathies and cardiovascular events 2 digital health integration aimed at improving the diagnosis of aortic stenosis and enhancing secondary prevention measures 3 pointofcare testing including the use of pointofcare diagnostics in primary practice and ambulances to exclude heart failure and 4 technology and robotics encompassing robotic echocardiography and invasive diagnostics in obstructive epicardial coronary artery diseaseeuroheartpath will create a paradigm shift in the management and treatment of heart disease offering substantial scientific societal and economic impacts across the entire patient health journey with a patient centric approach
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boosting the exploitation of standardisation inputs from european projects
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contributions from industry research and endusers involving experts that represent diverse stakeholders are crucial for the standardisation development however the standardsmaking process and rules are sometimes at odds with the culture and practice of research stand4eu aims to strengthen the links between research innovation and standardisation ensuring that standardisation is an integral part of the european research and innovation landscape stand4eu will map and identify key stakeholders and actors involved in standardisation activities at national regional eu and international level to allow a proper identification of the obstacles hampering the standardisation efforts within the scope of 4 main technological domains additive manufacturing welding smart manufacturingindustry 40digitalization artificial intelligence circular economythe key bottlenecks in the standards development lifecycle will be identified and to overcome the obstacles on the standards setting process a plan will be develop with recommendations and solutions to make the standards development process more efficient between the stakeholders from research innovation and standardisation a stand4eu interface will be created to facilitate the collection and the sharing of information about the obstacles and associated remedies and best practices towards the industrial and research innovation community the standards developing organisations the public authorities and other relevant stakeholders this will include pointers to available supporting services networking services herewith acting as a onestopshop for all related standardisation research and innovation mattersall the proposed solutions will be validated with the relevant actors and stakeholders to transfer the methodology to a broader scale of application in other respective areas to reach sustainable development of developed methodological approach and exploit the stand4eu interface globally
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inducing functionality in retinal organoids with electrical activities derived from developing retina
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deriving mammalian retina from stem cells has had a large impact on the study of the biology of vision and is called organoid compared to in vivo retina retinal organoids are far less functionally sophisticated in terms of their synapses connectivity discrimination between different light stimuli and their electrical action potentials this project will overcome this functional constraint of retinal organoids by studying electrophysiological eventsderived functional maturation of mouse retina during retinal development and then stimulating those events with the help of mathematical models in order to induce the same functionality in mouse and human retinal organoids neufro will achieve a resonance in the field by generating retinal organoids with the neuronal connectivity and the natural diversity of functions using interdisciplinary fields including electrophysiology developmental biology and computationallyderived electrical stimulation initially i will create a holistic roadmap of the electrical features of immature mouse retina during development that shows selforganization through electrophysiology with milli to nanometer imaging precision electrical activities derived the circuit formation will be spatiotemporally documented then i will decode this spacetime code of intrinsic electrical patterns and neuronal connectivity using an ambitious strategy incorporating hodgkinhuxley and linearnonlinear models next such electrical response models will be applied to immature retinal organoids mouse and human by an innovative sandwich electrophysiology technique during the development in vitro with this approach i will induce naturalistic electrical features in the retinal organoid allowing the functional neurons to wire and fire appropriately into retinal organoids particularly visual circuits this groundbreaking approach will advance techniques for generating functional human retina
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lineup longitudinal data for inequalities in education
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lineup aims at identifying key success factors for quality education for all by mapping and analysing the research design and findings of existing longitudinal data on students learning outcomes at primary and secondary level 618 yearold students considering that 2023 is the european year of skills and in line with the objectives of the european education area and council recommendation on pathways to school success the project focuses on achievement and attainment of basic skills lineup is based on a comprehensive desk research aiming at collecting analysing and summarizing data that allow assessing inequalities in education over time in 31 countries and with a particular focus on southern and western europe part of the activities are dedicated to understand to what extent different databases can be made directly comparable and deliver a feasibility study that brings innovation to the research community interested in comparative longitudinal analysis a qualitative research in project countries complements the mapping to gather primary data on the implementation process and impact of possible compensatory interventions in line with the findings of recent longitudinal studies the objective is to further investigate what schools can do to keep their students engaged meet their characteristics and needs and reduce inequalities in the short medium and long run lineup will contribute to expand the knowledge base on what shapes educational outcomes over time and on studentcentred interventions aiming at lifting the performance in basic skills and reducing early leaving from education and training which are a key challenge across europe attention will be dedicated to cooperating with national authorities of the participating countries to identify and access longitudinal data and other administrative sources and to validate and disseminate the results at european national and local level for a more supportive and equitable school environment
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versatile amplification method for singlemolecule detection in liquid biopsy
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robust detection of single molecules in complex biological fluids is the ultimate goal in the field of disease biomarker analysis conventionally to enable the quantitative analysis of individual molecules in macroscopic volumes analyte preconcentration and sample partitioning into flnl compartments has been combined with the amplification of the specific recognition events in these setups the positive or negative detection of fluorescence signal is triggered by enzymatic reactions occurring in each compartment binary readout based on poisson statistics quantifies ultralow concentrations of analyte molecules this approach has been adopted for nucleic acids analysis in current digital pcr and is also available for proteins in a technique coined as digital elisathe objective of versilib is to develop an enzymefree amplification strategy for the analysis of both protein and nucleic acid analytes with the single digital platform that offers means to access additional information on target analytes not achievable with current technologies method is based on novel affinitymediatedtransport amplification where affinity interaction of target analyte with a specific ligand attached to a magnetic nanoparticle transporter is accompanied with rapid shuttling of fluorescent tracers that serve as reporters by applying external magnetic field tracers are transported from the tracer storage side where they are dark to tracer active side where they become bright only if target analyte is present in the small reaction compartment tailored plasmonic nanostructures will be prepared at the storage and active sides of the compartment to render the tracer either dark or bright the aim is to perform technology validation for the novel versilib proteogenomics amplification platform in cancer management using biobanked liquid biopsy samples
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centre of excellence for safety research
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the use of hydrogen and other alternative energy sources as a clean and sustainable source have been gaining momentum worldwide due to their potential of reducing greenhouse gas emissions and supporting the transition to a lowcarbon economy to map analyze and understand the safety risks of the widespread deployment of hydrogen and other alternative energy technologies a new multidisciplinary research group has been established at the faculty of safety engineering fse vsbtechnical university of ostrava vsbtuo to reflect the requirements and needs of industry public authorities and other stakeholders to help them establish a safe environment promote public acceptance of these technologies and build a critical mass of knowledge for their further development safeenergy project will use scientific potential in the field of hydrogen and alternative energy sources safety and support fse in international networking projects and other initiatives on an international level this will be achieved through the leadership of the era chair holder experienced researcher and manager prof salzano from the university of bologna creation of a pocket of excellence centre for research on the safety of alternative energy sources and through building capacity in the field of research management and administration at the faculty of safety engineering vsbtechnical university of ostrava scientific collaboration will be established and developed through networking activities and joint research with industrial partners and international partners from europe and worldwide to increase excellence in energy safety with a focus on hydrogen cities and valleys the project will especially support young scientists postdocs and phd students to step up and stimulate scientific excellence and innovation capacity in hydrogen and alternative energy infrastructure safety the project proposes a comprehensive set of activities
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cinematic atmospheres towards a new ecology of the moving image
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cinema is not just a representational but also an operational medium its global success is indisputably tied to its ability to embed its audience in affectively charged atmospheric worlds and filmmakers carefully design their narrative worlds through ambient soundscapes music colorations filters camera movements production design mise en scne rhythmical editing and countless other features that arrange the emotional and affective experiences of the audience marginalized in film studies due to their ontologically indeterminate nature cinematic atmospheres operate affectively and prior to cognitive critical and analytical reflection this project examines cinematic atmosphere production in all its experiential aesthetic and ethical implications as an attractive but also problematic even harmful and ideologically loaded enterprise it raises critical awareness of the basic atmospheric operations of cinema in a time when the medium is relocated into new media environments and its techniques are reused within ecologies that are not cinematic per se such as news broadcasting videoconferencing sports refereeing and even terrorist recruitment this project i develops a broad conceptual understanding of cinematic atmospheres as a way of organizing the perceptive affective and cognitive epistemic access to the world of the film and ii mobilizes this understanding to develop a method for the study of the operations and techniques that constitute cinematic atmosphere production before iii expanding this method to deal with the question of how these cinematic operations and techniques for atmosphere production are no longer the property of cinema alone but increasingly employed outside of the narrativeaesthetic domain at the service of larger sociocultural economic and political forms of organizing perception cognition and affect from art installations to social media
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a prosthetic heart valve for adults and children made from the patients own tissue a replacement heart valve that lasts a lifetime
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each year 400000 people are born with heart valve defects worldwide moreover in the western world 1 in 8 healthy adults will develop a heart valve problem during their lifetime current artificial heart valves made from animal or human donor tissue carry a high risk of tissue rejection degradation and calcification that limit their lifespan to about 10 years forcing patients to undergo risky cardiac resurgery for children no dedicated valve product exists thus paediatric patients can endure 45 surgeries between 018 years of age as their bodies outgrow each replacement heart valve at grownvalve we have developed a paradigm shift in heart valve technology the first autologous valve grown from the patients own tissue crafted using medical imaging and a 3d printing technique our valve lasts a lifetime eliminating tissue rejection and surgical risks associated with repeated surgery bleeding infection and death
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women building brazil a history of architecture from the perspective of selfbuilding sites
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women building brazil wbb seeks to underscore womens contributions to architecture and construction in brazil particularly in contexts of selfbuilding its main objective is to address the neglect of both women and informal building practices in architectural and construction history especially in the global south the project will tackle that double historical gap by gathering personal stories and documentation on women builders its premise is that womens involvement in selfconstruction was actually quite common in vernacular architecture but has been affected by the introduction of new building technologies and materials expanding our disciplinary scope to include vernacular contexts wbb employs a novel method combining oral history with disruptive archival research methods and communitybased participatory practices guided by feminist and decolonial principles this approach will be applied in three territories in brazil where selfbuilding remains a prevalent custom quilombos afrobrazilian maroon communities indigenous territories and favelas urban informal settlements these distinct settings offer new insights to help recover analyse and acknowledge womens construction knowhow the outcomes of wbb include an oral history archive and a public video collection the participatory process will also generate a memory artefact cocreated with interviewed women with the purpose of recognizing their expertise and strengthening their building autonomy in summary wbb offers a new methodological approach to a growing field of construction history and a gendered analysis that contributes to the broader discipline of architectural history it maintains a commitment to open science through its research methodology and participatory practices ensuing constant dissemination of its results most importantly wbb actively seeks ways of empowering women in construction giving them voice and reaffirming the relevance of their knowhow
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gaming clusters across multiple european regions
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the main objective of the project gaming clusters across multiple european regions gameer is to research how video games clusters emerge develop and sustain themselves with particular focus on local and regional clusters based on this research gameer will formulate a series of policy and practical recommendations which will compose an interactive methodological toolkit these recommendations are aimed especially at local and national policy and decisionmakers with the intent to help them bootstrap cultural and creative industries clusters or strengthen existing clusters in their regions or citiesmuch of existing research on video game clusters concentrate on clusters outside europe or on european clusters in capital or large metropolitan cities such as helsinki or hamburg however local and regional clusters also are key drivers of innovation growth and cohesion and gameer will fill the gap around the limited knowledge we have about them to achieve its ambitious objective gameer a core component will be a comparative analysis of six local and regional clusters in five european countries which include france the czech republic italy scotland and portugal these clusters have been selected because of their different levels of maturity and their specificities such as the concentration of human creativity or companies moreover gameer will conduct a europe wide analysis of the spatial organization of the european video games industryecosystem with focus on local and regional clusters through this research the project will formulate policy and practical recommendations using a participatory approach and working with policy makers and the industry the project is organised in six work packages with 3 dedicated to research clusters and one focusing on building the project toolkit the project includes 16 partners from 9 countries with expertise in social sciences and humanities policy making the thirdsector business and innovation
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reinventing highperformance power converters for heavyduty electric transport
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rhodas project aims at developing disruptive topologies of power converters using new semiconductor materials as well as cuttingedge digital technologies to improve architecture efficiency power density reliability cost and sustainability moreover multidisciplinary approaches of modular power electronics for integrated motor drive imd and ecodesign considerations are addressed to create compact solutions that can be integrated in a wide range and heavyduty vehicles enabling these electric vehicles to be more sustainable and autonomous throughout the entire lifecycle of their components nevertheless power electronics solutions that use wide band gap wbg devices can also be applied to lightduty vehicle types m and l with competitive advantages on the efficiency and power densities compared with current technologies finally the rhodas project targets the validation of the proposed solutions in electric drivetrains of 1200v for zero emissions class n3 carriage of goods 12 tonnes and o4 trailers 10 tonnes which correspond to usa class 78 heavy duty vehicles 12 tonnes and beyond
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highthroughput screening synthesis and characterization of active materials for flow batteries
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predictor aims to establish a rapid highthroughput method to identify and develop materials for electrochemical energy storage this method will comprisea modelling and simulation tool for the computational screening of organic chemicals based on their potential performance in energy storage systemsautomated chemical synthesis electrolyte production and characterization methods so that the chemicals identified in the screening step can be rapidly produced and tested for their suitability in energy storage applicationsartificialintelligencebased selfoptimization methods that allow experimental data from material characterization to be fed back into automated experimental methods to enable selfdriving laboratory laboratory platforms and for modelling and simulation tools improving their accuracydata management systems to standardize and store the data generated for further use in model validation and selfoptimization proceduresthis approach will allow the rapid identification synthesis and characterization of materials within a coherent development chain replacing conventional trialanderror developments it will exploit the synergies between several emerging markets digital technologies artificial intelligence highthroughput experimentation renewable energy storage providing the recruited doctoral candidates dcs with a valuable interdisciplinary skill set to validate the predictor system the case study will be active materials and electrolytes for redoxflow batteries within the project three demonstrator battery cells trl34 will be assembled and tested with the newly developed materials
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emergent awareness from minimal collectives
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awareness in biological agents has converging definitions when considering local states describing contentrelated consciousness from an agentspecific perspective however it becomes highly debated when it comes to global states the issue magnifies when considering collectives of artificial agents several frameworks exist all unsatisfactory in the limitations posed to agents heterogeneity and disappearance of the local self into an integrated state ultimately existing frameworks are ineffective in explaining facilitating and supporting cooperative behaviours in artificial agents the lack of a compelling theory of global awareness in ai is currently a significant barrier to the effective deployment of artificial agents in the real world emerge tackles this grand challenge by introducing the novel concept of collaborative awareness for collectives of minimal artificial beings we will investigate how simple agents can develop a representation of their mutual existence environment and cooperative behaviour towards the realization of tasks and goals emerge builds on a scenario of artificial beings with no shared language and constrained individual capabilities which nevertheless leads to highcomplexity behaviours at the collective level collaborative awareness becomes an emergent process supporting complex distributed and loosely coupled systems capable of high degrees of collaboration selfregulation and interoperability without predefined protocols emerge delivers a philosophical mathematical and technological framework that enables us to know how and where to allocate awareness to achieve a goal through the collective optimally we will demonstrate emerge concepts on robotic use cases with hints of broader applicability of the framework to internet of things pervasive computing nanotechnologies we will also investigate the ethical implications of collaborative awareness focusing on moral responsibility vulnerabilities and trust
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democracyinaction grassroots culture arts and cultural spaces for political participation and expression online and offline in a resilient europe
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democracyinaction studies arts and culturebased grassroots organizations in physical spaces and their social media and metaverse dimensions to understand their critical potential in fostering democracy democracyinaction identifies solutions for increasing meaningful political expression and participation in four key areas of grassroots social transformation of untapped potential 1 nightivism urban nighttime cultural life for political engagement
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boosting the reduction of the environmental impact of pharmaceutical products throughout their entire life cycle
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eternal aims to contribute to sustainable development of pharmaceutical manufacture use and disposal by using and promoting full life cycle approaches covering design manufacture usage and disposal assessing the environmental risks of not only the api and residuesmetabolites but other chemicals and byproducts of the production process this type of approach is essential to take into consideration the types of green manufacturing approach under consideration by the pharmaceutical industry as evidenced by the range and scope of case studies being undertaken within eternal specific application of our risk and life cycle assessment approaches to the eternal case studies is a key element of the proposed work and will provide industry and policymakers with key examples of how whole life cycle assessment may be used to evaluate the changes in environmental impacts expected due to the introduction of green manufacturing processes
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from the margins to the masses standard practices and innovative uses of technology in augmenting different abilities of people in the world of work
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newworktech engages in researchbased enhancement of the workrelated capacities of a people with disabilities and b the general workforce with particular focus on technologically mediated tasks and interaction the project covers the entire arc of development from empirical research into how people with disabilities as forerunners of technology use perform tasks and interact at work to theoretical innovation regarding the nature of sociomaterial assemblages as well as what constitutes technology to policy recommendations and to the development of new technological solutions including aibased technologies we consider people with disabilities to be experts in using technical systems to improve their work performance and through an analysis of a variety of use cases will identify elements of successful use as well as factors that cause problems for interaction or the performance of tasks empirical results will also be generated by surveys and cocreation activities people with disabilities will be engaged in newworktech in line with the principle nothing about us without us ngo partners will be actively involved as facilitators in the empirical research and as drivers of application and dissemination through our own technological development effort attention to the ethical use of technologies and the dissemination of the knowledge we generate the results will feed into improved usage methods and functionality of workrelated technologies as well as knowledge about the required skills the smart use of technology thus achieved will help create employment opportunities for people with disabilities improving their quality of life and reducing inequalities while also helping alleviate the current shortage of labour in europe and open possibilities for more efficient and creative use of technology by everyone whether they have physical or cognitive limitations or not
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deciphering the interplay between stem cell differentiation and stem cell dynamics in branching morphogenesis
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tissue development requires the orchestration of stem cell differentiation and morphogenesis a process that is conspicuously observed in mammary gland mg branching the mg develops from an embryonic bud of mammary stem cells mascs although these stem cells are initially bipotent giving rise to the outer basal and inner luminal layers of the adult gland they become lineage restricted very early in embryogenesis at around the time of the onset of branching morphogenesis the timing of lineage restriction coincides with the differential expression of cell polarity and cell adhesion transcripts branching morphogenesis then relies on differential cell division as well as cell rearrangements and migration but the mechanisms regulating this process in the embryo remain poorly understood based on these observations we postulate that basalbiased and luminalbiased mascs have distinct molecular features during branching morphogenesis we therefore propose to functionally link the signaling pathways involved in restriction of stem cell potency to the cellular dynamics that ensure branching to this end we will characterize the dynamic behaviour of individually labeled mascs during the growth of embryonic mg explants and assess their fate creating a complete fatebehavior map of mg development through genetic manipulation we will probe how cell adhesion migration and division impact on lineage specification and tissue growth simultaneously we will skew stem cell differentiation trajectories and assess their influence on cell behavior and organ shape the outcomes of this project will provide novel insights into the coordinated developmental programs governing stem cell fate and morphogenetic events both essential to tissue formation moreover they might uncover potential connections to cancer where differentiatiom and cell polarity play pivotal roles
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safe and sustainable by design graphenemxenes hybrids
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the safari project aims to develop new 2d materials using sustainable and safe processes the project focuses on creating hybrid formulations of mxenes and graphene gr which are known to possess unique and desirable properties such as thermal stability electrical conductivity the goal of the project is to develop sustainable and safe materials that can be used in a wide range of applications such as biosensors conductive ink and emi shielding the safari project begins with the preparation of precursor compounds known as max phases these compounds are then used to produce two types of mxenes ti3c2 and cr2c which are further functionalized to enhance their properties and increase their affinity with graphene the resulting 2d hybrid materials are created using two different methods and their structural morphological and functional properties are thoroughly examined one of the main strengths of the safari project is that is allinged with the ssbd principles thus assessment of the toxicological and ecotoxicological profiles of the new materials through a range of tests and assays will be conducted in conclusion the safari project represents a significant step forward in the development of 2d hybrids with mxenesgraphene for use in a wide range applications
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from sky to seafloor observation achieving excellence in oceanic surveillance and conservation through deep learning
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technological areas such as artificial intelligence ai and ecosystems such as shipping maritime and space have been strategically prioritised by cyprus to improve its research and innovation ri performanceat their intersection lies the need to enhance marine conservation efforts and maritime surveillance by leveraging deep learning dl methodologies built on standardized and robust data sets indeed insitu sampling stands as a cornerstone in marine conservation offering a direct approach to monitoring marine biodiversity while remote sensing stands as a pivotal addition to maritime surveillance expanding the scope beyond traditional automatic identification system capabilities dl as a cuttingedge ai tool holds immense potential to enhance the analysis of insitu samples and remotely sensed dataaxolotl is proposed as a transformational international endeavour capable of enhancing the ri capacity of cmmi cyprus and europe in the interdisciplinary fields of dlenhanced insitu biodiversity assessment and dlenhanced remote sensing for maritime surveillance the project will contribute to closing the gap between a h2020 teaming centre of excellence and 2 strong innovators from france and belgium through capacitybuilding knowledge transfer networking and outreach activities at regional and international levels activities will go beyond the strictly scientific scope and support the mutual development consolidation and reinforcement of administrative dissemination and entrepreneurial competencies access to networks of excellence and the sustainable linkage between partners the projects ri component will develop new strategies for improving data quality standardization and synchronization issues devise novel interdisciplinary methodologies develop robust dl models from stateoftheart computer vision methods and validate its proposed solutions in 2 relevant realworld contexts biodiversity assessment and maritime surveillance
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sustainable careers for researcher empowerment
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the sustainable careers for researcher empowerment secure project will develop coordination and support measures to create trial implement and mainstream a common research career framework rcf that offers a suite of options to support organisations in the recruitment employment training development progression and mobility of researchers with the aim of improving research careers and reducing career precarity the rcf will recognise the research profession across sectors provide a career development and progression structure for research careers recognise both research and transferable skills and competences facilitate intersectoral collaboration and mobility and offer solutions to the precariousness of research careers in academia secure will test aspects of the rcf and ttl models in trials in four rpos one rfo and one recruitment agency the trial organisations will first conduct a scoping exercise to map the rcf onto their existing policies and activities for research careers before developing integration plans on how the rcf could be adopted into their existing policies and activities due to the short duration of the project and window for trials it is expected that only some aspects of the rcf and ttl models will be tested the trial organisations will thus develop actions plans selecting relevant aspects from the integration plans to test and implement during the trials secure will mainstream the rcf and ttl models through a series of policy briefs and a summit that explain key aspects of the rcf and ttl models to relevant organisations employing researchers the rcf and ttl models will be further promoted through key partner organisations in the project targeting researchers rpos and companies the rcf and ttl models will lastly be promoted in the euraxess network including the many euraxess service centres the newly established euraxess hubs and through the era talent platform being developed
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technology for european independence in space image sensor
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the objective of the technology for european independence in space image sensors tensis project is to develop manufacture and validate a scalable largearea highresolution radiation tolerant customizable and affordable 180nm cmos detector with the key technical characteristics of a 24k x 16k format matrix of 400mpixels the targeted pixel pitch is 35m to keep the overall matrix manufacturable with the proposed xfab 018m cmos image sensor process and with high full well capacityoverall pixel electrooptical performances including mtf and spectral features will be enhanced by the design and implementation of specific optical stack in back side illumination configuration combining rgbnir filters with flat microlenses as a by product of the design of the 24k x 16k detector a 4k x 4k detector will also be designed and manufactured by te2v in fsi then bsi configuration te2v will package produced dies in pcb package and deliver them to airbus defence and space in toulouse for detailed functional electrooptical characterization before this characterization test campaign airbus will develop dedicated test means including proximity boards both matching with the 24k x 16k and the 4k x 4k detectors in close cooperation with teva group of 4k x 4k bsi detectors initially electrooptically characterized by airbus will then be delivered to alter at sville to be submitted to dedicated environmental tests including tid tnid and heavy ions radiation campaigns as well as burnin and power onoff cycling tests thanks to this test campaign the 4k x 4k detector die will reach trl7 by the end of the project the project will further aim at creating a strategic competitive advantage for the european partners prime and equipment manufacturers and reduce the dependence on critical technologies and capabilities from outside eu it will rely on the xfab foundry which is key for the tensis project
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firstinclass myc inhibitor the making of a breakthrough cancer therapy
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pancreatic ductal adenocarcinoma pdac is one of the most lethal cancers with very few and often ineffective therapeutic options despite recent advances cancer therapies remain ineffective andor highly toxic our approach is targeting myc a function essential to cancer cells that allows them to survive and develop resistance to therapy in contrast to standard drugs inhibiting myc selectively blocks tumor progression without causing important side effects myc has been considered undruggable for a long time and no clinical myc inhibitor is yet marketed peptomycs firstinclass drug omo103 is a cellpenetrating miniprotein that derives from omomyc the best myc inhibitor known to date omo103 recently completed a phase 1 clinical trial that confirmed its safety and clinical activity in allcomers solid tumor patients causing a 49 tumor shrinkage in a pdac patient and stabilizing the disease of 8 out of 12 evaluable patients moreover using ai we identified a predictive and a pharmacodynamic circulating biomarker signatures and generated companion diagnostic for stratification and realtime response monitoring tests for omo103 omo103 and its companion diagnostic tests offer a promising therapeutic option for a disease in great need and could apply to treat many other cancer indications the next steps and goals of this mycurex project consist of conducting a phase 1b trial in 1stline pdac patients combining omo103 with the standard of care to evaluate its safety and clinical activity refining the companion diagnostic prototypes and app securing the scaleup of the innovation by developing a commercialscale compatible manufacturing process and expand the applications of omo103 and peptomycs drug pipeline by completing mycurex peptomyc will consolidate the therapeutic potential of myc inhibition in cancer patients improving their survival and quality of life while establishing itself as a european leader biotech in myc targeting
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design and implementation of an advanced nonlinear and nongaussian data assimilation algorithm for bounded variables in numerical weather prediciton models
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hazardous weather events affecting populated coastal are among the most devastating natural disasters in terms of mortality and economical losses due to their low predictability currently the generation of useful predictions reliable and anticipated of hazardous weather events affecting populated coastal regions remains an ambitious challenge for the scientific community deficiencies in the accurate prediction of such events are tightly related with the initial value problem which states that better the state of the atmosphere is estimated the more accurate the forecasts this problem is addressed by using advanced data assimilation da techniques which play an important role in current numerical weather prediction and is currently at the forefront of atmospheric and oceanic sciences research however although using the most current sophisticated da algorithms the estimation of the atmosphere is not accurate enough to improve the predictability of hazardous weather events mainly because their linear and gaussian underlying assumptions the main aim of the present project is to go beyond the state of the art in da by developing and implementing a novel and advanced da technique that takes nonlinearities and nongaussianities into account enabling us to to improve highimpact weather forecasts the new da will be tested in real cases in combination with a highresolution atmospheric model to improve the predictability of several poorly forecasted mediterranean hurricanes this novel technique will significantly improve global regional and climate forecasts the applicants strong mathematical and theoretical skills in da together with his broad experience running numerical weather models using hpc facilities will facilitate the achievement of the key goals of this proposal this project will also expand the applicants experience research competencies and professional networks enhancing the development of his career as an independent researcher
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rna processing for anticancer immunotherapy
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in the past five years rna therapeutics have witnessed a true revolution several rnabased therapies have been approved for the treatment of genetic diseases with unprecedented successes as in spinal muscular atrophy moreover the past year showed the world that rnabased therapies namely mrna vaccines can be the answer to a worldwide pandemic and save the lives of millions rna therapies are however lagging behind in clinical oncology the overarching aim of this multiarmed project is to develop rnabased cancer treatmentsin parallel the development of immune checkpoint inhibitors has revolutionized cancer care but its success remains limited to a subset of patients altogether for 60 percent of the eight million new cancer patients diagnosed in europe each year including almost all children with solid tumors there is no ema or fdaapproved immunotherapy option and they are left out of the circle of hopein response cancerna aims to build on these two breakthroughs and apply rnabased therapeutics to overcome key barriers to unfold successful anticancer immune responses our two key objectives are on one hand harness the modulation of rna processing to enhance the accessibility and immune susceptibility of the tumour and its microenvironment while on the other hand enhance the activity of the immune system by retargeting immune effector cells modulating rna splicing of key immune receptors and developing personalized mrna vaccines the project will focus on two cancer types harboring splicing factor mutations and being generally refractory to immunotherapy acute myeloid leukemia relevant for pediatric cancer and uveal melanomathe collective knowledge of our consortium of rna scientists clinicians and biotechpharma experts in rna processing rna drug design and delivery biocomputing and immunooncology provides a unique opportunity to significantly advance novel rna technologies into successful cancer therapies
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reconfigurable heterogeneous highly parallel processing platform for safe and secure ai
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rebecca a heavily smedriven project will democratize the development of novel edge ai systems towards this aim rebecca will develop a purely european complete hardwarehw and softwaresw stack around a riscv cpu which will provide significantly higher levels of a performance eg inferences per second b energypower efficiency eg inferences per joulewatt c safety and d security than the existing ones this will be achieved by utilizing stateoftheart technologies and by making significant scientific and technological advances in several key relevant domains including a processing units b hardware accelerators c reconfigurable hardware d tightly coupled interconnected chiplets e hwsw codesign and codevelopment tools f system software g middleware and h ai libraries and frameworks rebecca will significantly contribute to realizing business and societal opportunities by validating and demonstrating its approach on 4 realworld use cases and 2 benchmarks based on realworld applications from the smart appliances energy generation infrastructure inspection avionics automotive and health domains in terms of hw rebecca will develop a novel chip consisting of two tightly coupled chiplets which will incorporate a riscv multicore b neuromorphic ai accelerator c programmable array ai accelerator d ai accelerator utilizing a hierarchical processing architecture e dnn accelerator f reconfigurable hardware g nearmemoryprocessing h memory encryptionin terms of sw rebecca will implement optimized system sw middleware and ai libraries that will take full advantage of the underlying novel hw the rebecca platform will be complemented by a novel hwsw design space exploration tool which will allow the development of highly efficient rebeccabased systems rebecca will additionally provide the means for safety and security modeling and verification for the developed hw and sw from the very early design stages
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humancentric artificial intelligence for sustainable future
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for the eu to strengthen its role as the global leader in trustworthy ai experts on ethical humancentric and sustainable use of ai are urgently needed in public private and third sector organisations across member states this interdisciplinary expertise is not readily available through traditional doctoral training frameworks the fastevolving field will continue to create opportunities for individuals with resilience and futureproof skills humancentric artificial intelligence for sustainable future haif is a doctoral programme for 25 doctoral candidates dcs hosted by the university of turku utu finland and supported by 17 associated partners haif will establish a novel doctoral training scheme that connects utus faculties of technology social sciences law and humanities haifs research themes are societally relevant emphasizing humans as developers users and decisionsubjects affected by the technology in addition to individual and societal perspectives haif produces technological solutions for improved safety security interpretability and technical robustness of ai systems research on application areas such as health care autonomous systems and cybersecurity will be transferable to different sectors haifs academic collaboration network covers 7 eu countries and the us 6 nonacademic partners bring in business relevance and views of the public administration besides enhancing dcs academic skills and producing new interdisciplinary knowledge haif will train dcs on transferable skills such as communications and project management which are essential for widening their career prospects haif dcs will be selected through a transparent meritbased process with equity and inclusivity as crosscutting priorities by training the future professionals in the critical themes of humancentric and sustainable ai haif increases competitiveness jobs and growth from the regional to eu scale
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bridging fundamental knowledge and novel technology to increase rice heat tolerance
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seeds are the link between the end of the reproductive cycle of adult plants and the establishment of their next generation seeds are the means through which plants can adapt to climatic changes feeding the evergrowing population is a major challenge especially in light of rapidly changing climate conditions genome editing is set to transform plant breeding and help secure the global food supply advances in genome editing technologies provide new opportunities for crop improvement by employing precision genome engineering for targeted crop traits this proposal which addresses critical stages of the reproductive development integrates several approaches to comprehensively investigate sexual reproduction in rice under heat stress hs conditions with the aim of using the novel knowledge generated to improve rice production the model plant system arabidopsis thaliana will be used as proof of concept to generate quick knowledge that can be readily translated into concrete outcomes in rice specie of high importance to the european agricultural sectorcrispit main goal is to understand the mechanisms that regulate heat stress tolerance during the reproductive process in rice crispit will provide answers to the following questions how plant reproductive cells and tissues are affected by heat stress what are the molecular mechanisms underlying rice plants resilience to hs during reproduction to answer these crispit proposes to achieve three main objectives 1define hs features and marker genes in nagina22 rice variety 2 generate a new transcriptomic dataset 3 obtain and fully characterize mutants from the chosen genes in order to deliver rice hs lines produced by crispr technology
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coordinating and piloting actions towards erahubs as inter and intraregional ecosystems for knowledge production
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cooperate overall objective is to develop and pilot the era hub concept based on the vision and success stories developed within the eurotech universities alliance and their ri ecosystems the overall approach revolves around cocreation arenas in which ecosystems and a broader community of quadruple helix actors can interact the piloting phases of the projects implementation are expected to test the approach and pave the way for its consolidation and replication phase the approach follows a mechanism in which leverage is sought to engage a broad range of stakeholders activate crossfertilization facilitate mutual understanding create intertwining cooperation and jointly develop innovative ideas for shaping the era hub framework model for further piloting and validation the intended era hub model builds on lines of action eg access to knowledge and talents which gather a set of initiativesprojects to animate the actors and stakeholders and operate the ecosystem around common priorities ie strategic multiannual roadmap which reflect the missionbased approach in this framework the key exploitable results include 1 the era hub model and associated playbook toolbox and platform with compliance criteria to develop the era hubs network 2 the policy recommendations and content from cocreation activitiesthe consortium is aware that the outcome of the project is supporting the ec roadmap towards the launch of era hubs as flagship initiative in europe to boost the era beyond the scope of the project tailor made communication dissemination and exploitation actions will therefore create awareness and engagement within regional ecosystems in eu building consensus in a close dialogue with eu and nationalregional institutions in particular two large events will be organised in brussels at midterm and at the end of the project for consensus building on the project findings and policy recommendations
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noncommutative ergodic theory of higher rank lattices
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noncommutative ergodic theory of higher rank lattices is a current topic that has seen several exciting developments in the last five years among these recent advancements in joint work with rmi boutonnet 2019 we proved a noncommutative analogue of nevozimmers structure theorem for actions of higher rank lattices on von neumann algebras first of all we derived several novel applications to ergodic theory topological dynamics unitary representation theory and operator algebras associated with higher rank lattices then we obtained a noncommutative analogue of margulis factor theorem that provides strong evidence towards connes rigidity conjecture for the group von neumann algebra of higher rank lattices these results revealed deep and unexpected interactions between the field of discrete subgroups of semisimple lie groups and the field of operator algebras in this research project i plan to build upon these recent achievements to develop new directions in noncommutative ergodic theory of higher rank lattices this research proposal is centered around two main interconnected themesfirstly i plan to work on several problems and conjectures around the dynamics of the space of positive definite functions and character rigidity for higher rank lattices these include the classification of characters for higher rank lattices of product type and more general lattices with dense projections in product groups as well as stiffness results for stationary positive definite functionssecondly drawing inspiration from margulis superrigidity theorem i plan to tackle connes rigidity conjecture for higher rank lattices by developing a novel strategy combining techniques from boundary theory calgebras and von neumann algebras these methods will lead to new rigidity phenomena for operator algebras arising from irreducible lattices in higher rank semisimple connected lie groups
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synchronised neuromemristive architecture for reinforced learning technology
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rapid progress in the regime of artificial intelligence and internetofthings has enthused the development of fast and energyefficient hardware to support future computing needs one of the most prominent solutions is the deployment of crossdisciplinary resources for mimicking the performance of a human brain also known as neuromorphic computing it relies on electronic components that could replicate the functioning of neurons and synapses designing such novel electronics needs the development of costeffective fast and reliable materials with tunable functionality a fundamental understanding of these materials will pave the foundation of innovative device designs and strategies for their largescale integration for neuromorphic architectures in this context the proposed project intends to deliver artificial neurons by developing thinfilms of a novel material tbmno3 that is capable of demonstrating a negative differential resistance ndr the idea is to utilise the fundamental understanding of multidimensional electrical optical mechanical and magnetic control of ndr which is not explored yet and is possible in tbmno3 ndr enables a twoterminal device to display selfoscillations due to applied electrical spikes the spiking electrical currents could be used to govern the behaviour of these oscillations and emulating the leaky integrate and fire behaviour of biological neurons once such a performance is achieved the device will further be integrated into oscillatory neural networks array for demonstration of complex computing tasks such as image recognition and imitating human behaviour the project will unite the applicants expertise in synaptic devices and materials engineering with the extensive experience of the hostlabs in thinfilm and neuromorphic devices importantly the project will warranty catapulting the applicants international recognition as an independent researcher and will improve his career prospects
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capturing ultrafast electron and ion dynamics in batteries
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batteries are attractive candidates for lightweight high capacity mobile energy storage solutions despite decades of research a persistent fundamental knowledge gap prevents batteries from fulfilling their potential because the atomistic mechanisms of charge and ion transfer across interfaces in batteries remain largely unexplored by experimental techniques when charges move the local arrangement of atoms changes in response to the new electronic configuration how these changes occur has a significant impact on how efficiently and how far the charges can move yet the time and length scales are still poorly understood conventional experimental probes used in battery research cannot provide the needed ultrafast time and atomic length scale resolution nor sensitivity to changes in electronic configuration around specific atomic species hence it is currently challenging to unravel the dynamic rearrangement of atoms and ions which accompany electron transfer and in turn govern the charge transfer processesultrabat will close this knowledge gap by pushing further the latest development of ultrabright and ultrafast xray free electron laser xfel scattering and spectroscopy techniques together with visible ultrafast spectroscopy to study charge transfer between different redox centres in lirich layered intercalation compounds and at the solidliquid interface advances in nmr spectroscopy will reveal local ordering and lithium interfacial dynamics on the nanometer scale coupled with predictions of experimental observables from a new framework for atomicscale simulations of the electrochemical interface and transport mechanisms we will reveal phenomena driving diffusion of ions in complex electrode materials this will provide the insight required for transformational approaches to control the redox reactions eg electron transfer that are common to many energyrelated processes including batteries photovoltaics and watersplitting systems
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theranostic magnetic nanobased codelivery system for boosting cancer immunotherapy
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cancer is a leading cause of death and a major impediment to increasing life expectancy around the globe amongst all skin cancers melanoma is a hardtotreat disease owing to its high potential for metastasis and it remains as one of the most aggressive cancers single therapy is not efficient to tackle metastatic melanoma and a combination of therapies is thus emerging as a necessity to efficiently eradicate all cancer cells recently immunotherapy in particular immune checkpoint inhibitors ici has become a powerful treatment strategy for cancer nevertheless the physical barriers represented by cellular and noncellular components of the tumour microenvironment combined with immune escape mechanisms of cancer hamper an efficient tumour infiltration and patients responsiveness to ici therapy in this context multitheranostic aims to develop theranostic nanoparticles for gene therapymediated immune checkpoint silencing and chemotherapy exploiting the properties of magnetic nanoparticles to induce damage locally on the tumour microenvironment by magnetic hyperthermia mh this multimodal theranostic approach incorporating mri tracking is versatile as it could be also applied to other types of solid tumours multitheranostic objectives are i to synthetize and validate a biocompatible magnetic lipid nanoparticle nps incorporating silencing rna against ici targets and chemotherapy wp1 wp2 ii to develop a tissueengineered te model for screening and monitoring the efficacy of the nps wp3 and ii to demonstrate the effectiveness of the final drug delivery system as a multimodal theranostic approach for metastatic melanoma wp4 with multitheranostic the researcher will greatly expand her scientific expertise in the fields of nanotechnology and bioengineering positioning her as a leading independent researcher contributing to the advancement of nanomedicine in europe and beyond
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the future of eu digital investments throughout the value chain
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the ambition with the proposal is holding a conference to foster an early and inclusive european discussion on the future role framework and prioritization of eu digital investments this in order to have a qualified and informed policymaking in view of upcoming legislative proposals aligned with the priorities of the next european commission 20252029 and informed by existing eu programmes horizon europe and digital europe concretely this will take the form of discussions of the inspiring and relevant topics both policy discussions as well as implementation issues an interactive approach with debates digitally enabled polls during sessions and networking opportunities livestream and recordings of the sessions together with a conference report will give the conference reach in the entire eu
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multiscale mechanobiological synergies in vascular homeostasis ageing and rejuvenation
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whilst 30 of eu citizens will be over 65 and 10 over 80 by 2050 the healthspan accounts for only 80 of the total life expectancy according to eurostat due to the high prevalence of disabling diseases related to the ageinduced arterial stiffening the current paradigm in medicine is to palliate these diseases with sophisticated devices in juventwin i propose a complete shift of paradigm by combatting the mechanobiological effects of vascular ageing vascular rejuvenation faces many challenges that have only been explored by molecular biologists my ambition is to address these challenges with a highrisk approach relying on multiscale digital twins and enabling to simulate and screen effective rejuvenation treatments my hypothesis already supported by preliminary results is that this can be achieved by doping the synergistic effects of mechanoregulation in human arteries which are gradually compromised with vascular ageing juventwins four specific objectives are 1 decipher how ageing affects cell phenotypes and the signalling pathways of mechanoregulation 2 assess the effects of ageing on the mechanical interactions between cells and their matrix 3 simulate computationally the multiscale synergies participating to patientspecific vascular mechanoregulation and finally 4 take the control of mechanobiology in aged arteries using small molecule inhibitors and cell mechanical stimulations with my team we will reach these objectives by developing two completely novel methodologies a 4d highresolution strain mapper and a micromechanical computational model simulating the dynamical interactions of 100000 vascular cells in patientspecific arteries our interdisciplinary approach combining digital spatial transcriptomics laser interferometry and neural networks will be of very highgain for discovering therapies against the adverse mechanobiological effects of vascular ageing potentially reaching the preclinical stage at the horizon 2030
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imprinting and clonality of human nk cell memory
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the pool of innate immune effector cells is wired to rapidly respond to pathogens whereas only few specificities within the nave adaptive repertoire expand clonally undergo epigenetic remodelling and differentiate into effector and memory cells however innate cells can differentiate upon pathogen encounter and remember past experiences as well thereby challenging this strict dichotomy in particular us and others have shown that human memory natural killer nk cells with global epigenetic remodelling can be generated in response to specific signals during cytomegalovirus cmv infection we have recently identified two major types of open chromatin domains in human memory nk mnk cells ex vivo first a shared signature featured by all mnk cells across cmvseropositive donors public memory second a diverse set of unique open chromatin regions associated with the drastic expansions of individual and stable nk cell clones private memory based on this unexpected finding we hypothesise that the shared and the unique clonal memory might provide mnk cells with increased fitness and high effector potential but also enhance the risk of oncogenic mutationsthe ultimate goal of this project is to identify the signals and molecular mechanisms driving acquisition selection and maintenance of human nk cell public and private clonal memory to this end we will combine multiomic single cell assays and lineage tracing of human nk cells from healthy donors and patients ex vivo or under various stimuli in vitro with genomewide crispr perturbation studies to directly link ex vivo features with functional read outs success of this project will not only lead to new insights into the key networks promoting persistence and effector functions of mnk cells but also reveal promising novel targets for cellular antitumour therapies
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offshore freshened groundwater prospecting using machine learning
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offshore freshened groundwater ofg refers to fluids stored in sediment pores and rock fractures below the seafloor with a salinity lower than seawater this phenomenon has been identified globally in continental margins and proposed as a resource that can potentially alleviate water stress in coastal regions however the scarcity of data to constrain the distribution and volumes of the reservoirs remains a challenge optimal project aims to i develop an interdisciplinary methodology to predict the occurrence and distribution of ofg resources built on artificial intelligence and ii apply the model globally to infer ofg occurrence and quantify the resource feasibility as a function of distribution characteristics such as offshore extent depth below the seafloor and fresh to brackish water ratio the proposed methodology uses a surrogate model to create a dataset of input parameters representing key geological and geomorphological components influencing ofg systems such as aquitard thickness and seafloor bathymetry the output data will be generated via numerical simulation of variabledensity groundwater transport on the suite of surrogate models using highperformance computing these data will be used to train and test machine learning algorithms the successful models will be validated using realworld data from the existing global ofg database the predictive model proposed in this fellowship contributes to achieving sustainable development goals related to technologies for improving access to water resources the primary beneficiary of this funding will be the university of malta partner organizations will be utrecht university and deltares in the netherlands the action presents a unique opportunity for the fellow to transfer his expertise in stochastic reservoir modelling and characterization of ofg systems to the host while learning about marine geology seafloor landforms and applied machine learning
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personalized noninvasive neuromodulation in pain
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chronic pain cp is the most prevalent disease worldwide and is a major societal challenge different people with the same pain condition experience it differently irrespective of its origin cp is maintained by altered connectivity between brain regions which can be modulated towards normality by effective treatment several pharmacological and nonpharmacological strategies exist to treat pain but 40 of individuals remain symptomatic despite treatment current treatment for cp is not personalised being delivered in a standardised regimen irrespective of patients brain network status which partially justifies therapeutic refractoriness noninvasive neuromodulation nin techniques such as repetitive transcranial magnetic stimulation rtms are used in the longterm treatment of a wide spectrum of brain disorders as an alternative to medicationexclusive regimens nin can modulate altered connectivity towards normal patterns and relieve symptoms with minimal side effects but to date its application has also been nonindividualized which equally impacts its therapeutic potential i propose a comprehensive package of studies using measurements of localtoglobal brain connectivity to individualize pain treatment by probing different brain regions by single pulsetms and reading the subsequent brain oscillatory responses by electroencephalography one can screen potential treatment targets and classify them according to their efficacy potential in a pretreatment session this will allow the identification of the best cortical region to be used as treatment target by rtms thus providing a personalized choice of the ideal entryspot to drive brain global connectivity towards normalized patterns for each patientwith the development localtogeneral brain connectivity metrics guiding nin treatment personinpain will provide an innovative and groundbreaking approach to transform the treatment the worlds most impactful health condition chronic pain
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scaling minima ultralow energy computing technology to make intelligent wireless devices energy efficient
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number of wireless devices is growing rapidly today there are 30 billion wireless devices in circulation like our smartphones however by 2035 there will be 1 trillion of these wireless devices in circulationnearly each of these devices has a brain called a microprocessor unlike brains their energy efficiency leaves a lot to be desired this is why minima exists we make microprocessors consume radically less energy using our ultralow computing technology this makes wireless intelligent devices energy efficientour patented technology consists of hardware software components that are directly integrated into microprocessors prior to manufacturing this enhances performance energy efficiency of wireless devices that power the internet of everything that are often tasked with collecting analysing data directly at the sourcethis allows us to enter the 63 billion semiconductor market and change the markets energy consumption from the inside out
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inadequate migration of leishmaniainfected macrophages the driver of parasite dissemination
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leishmania parasites a threat to 350 million people worldwide are transmitted by sand flies and reside predominantly intracellularly in macrophages leishmania species can remain local cutaneous leishmaniasis or spread throughout the tissue and body mucocutaneousvisceral leishmaniasis this is the difference between a mild illness or a deadly disease and the fundamental mechanisms behind these different clinical manifestations are largely unknown as leishmania parasites seem immobile following their delivery into the skin and are rapidly phagocytosed it has been hypothesised that dissemination is driven by host cell migration in a speciesdependent manner specifically previous studies showed that leishmania species causing visceral infections typically enhance macrophage motility while species linked to cutaneous lesions slow down infected macrophages however few studies have directly compared migration of parasitised macrophages across multiple leishmania species and it remains unclear which host migration pathways leishmania manipulates we want to test the hypothesis that different leishmania species alter integrindependent and independent macrophage migration modes in distinct ways to control dissemination through the dermis and across endothelial barriers using human skin equivalents cell deformability assays and two and threedimensional migration assays we will measure changes in migration dynamics of leishmaniainfected macrophages additionally we will perform drug inhibitor and crispr screens targeting macrophage genes to identify host pathways essential for migration of parasitised macrophages to dissect speciesrelated differences this study will use species causing visceral mucocutaneous and cutaneous leishmaniasis the results will give insights into leishmania dissemination mechanisms thereby facilitating future designs of new therapeutics aimed at controlling inadequate migration of infected macrophages
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nanoscintillators to potentiate brain cancer radiotherapy from physics to preclinical trials
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more than 50 of cancer patients undergo radiation therapy rt in the course of their treatment however because of a lack of specificity for tumor tissues delivering therapeutically effective doses of x rays with tolerable toxicity on healthy tissues remains a challenge glioblastoma multiforme gbm the most common primary brain cancer in adults has a dismal prognosis despite an aggressive standardofcare developing new strategies to improve the therapeutic index of rt is therefore of major importance the aim of this project is to comprehensively study the multifaceted radiotherapeutic effect of nanoscintillators ns and determine how to harness these effects to improve the therapeutic index of rt by converting highenergy photons such as xrays into uvvisible photons ns can augment rt by various effects these include radiation dose enhancement radioluminescenceinduced photodynamic therapy and dna damage generated by uvradioluminescence this project has three main objectives 1 to elucidate the physical and photochemical origins of the radiotherapeutic effects of ns using spectroscopic studies to identify the reactive oxygen species and dna lesions generated upon xrays 2 to study the biological impact of the ns on 3d models and in syngeneic rat models of gbm 3 to develop an in silico program that simulates the efficacy of prospective ns and studies the impact of their composition size and morphology this will tailor future ns to specific malignancies with distinct biological properties with this innovative methodology and an interdisciplinary approach that ranges from physics to biology this project will provide groundbreaking fundamental knowledge on the radiotherapeutic effects of ns that may lead to highly valuable and clinically translatable therapies in the longterm this strategy may be tailored for pancreatic and metastatic ovarian cancers for which the multifaceted enhancement of rt efficacy by ns may be of great interest
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developing a frameworkmodel to environmentally sustainable and climate neutral health and care systems using the kidney care pathway
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current measures in healthcare systems are insufficient to reach the eu green deal goals the social economic and clinical consequences are significant reasons that current initiatives fall short include lack of awareness as to the problem or potential solutions there is complexity as to what process to choose the low cost the low carbon the one that provides better care or the one which has the better social impact the current system has insufficient investment in sustainable education policy or research solutions work well in limited areas but are inefficient as a model for true systemic change there is no agreed system of environmental foot printing in the health system and few partnerships with industry and patients to develop a truly sustainable system kidney care is a suited test case with its large resource footprint and welldefined care pathways kitnewcares consortium will solve the problem with leading experts in kidney care life cycle assessment methodology education dissemination and communication health economics and data management kitnewcare will perform an euwide mapping of the sustainability landscape to reveal the hotspots across different clinical centres in each impact area to locate solutions quality improvement cycles will be utilised to analyse clinical pathways and industry innovations kitnewcare will codevelop and pilot sustainable tools such as the purposefully developed actionable dashboard based on the 4factor lca model which will monitor and benchmark the 4 different outcomes innovative solutions training guidelines and recommendations as a proof of concept which can then be applied to the healthcare system our work will be informed by a stakeholder interaction and a patient and public involvement programme to ensure proper design uptake dissemination and exploitation this will enable decision makers and healthcare providers to reduce pollution carbon emissions and waste
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an ecological history of eurasian art natural resources aesthetic practices and early modern globalization
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works of art are repositories of environmental knowledge paintings sculptures and artifacts preserve material evidence of the use of natural resources like mineral pigments plantbased dyes and precious metals and contribute to a visual archive of human interaction with nature by providing pictorial records of mining and deforestation ecoart aims to rewrite art history as a history of ecological interconnections and prove that aesthetic practices were conditioned by environmental circumstances by examining the artistic use and visual representation of geographical geological botanical zoological and climatic resources across eurasia a space dominated by european and chinese economic spheres of influence in an era of early modern globalization from 1500 to 1800 the project investigates six key artistic sites with a focus on the global south an area still affected by the colonial exploitation of resources the indian region of gujarat and the port cities of manila in the philippines jakarta in indonesia guangzhou in china yangon in myanmar and amsterdam in the netherlands with three objectives 1 to analyze works of art as early modern repositories of environmental knowledge 2 to reconstruct local ecologies of art and artisanship in the global south in relation to trade and colonial exploitation and 3 to make visible transcultural models of sustainability and creative reuse across early modern eurasia digital mapping will demonstrate linkages between sites of artistic activity resource extraction and trade via overland and maritime connections through a geographic focus on underresearched regions of the global south and its transcultural and comparative methodology ecoart will contribute to the decolonization of art history provide theoretical insights into circular economies and the ecology of art and contribute key historical information to an interdisciplinary understanding of natural resource conflicts during the anthropocene
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enhanced interfaces and train categories for dynamic compatibility assessment of european railway bridges
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the shift to more sustainable mobility systems is one of the major priorities to accomplish the goals established by the european green deal to make europe the first climate neutral continent by 2050 railways plays a crucial role in this regard but it is essential to enhance the current resilience and capacity of the network in particular from lifeline structures such as bridgeswithin this regard several open points affecting the current inf tsi and described in the era technical note are yet to be closed namely those related to the dynamic train categories previously specified in en152282015 and the limits of validity of the static compatibility checks currently stipulated en152282021 the accuracy of the current dynamic amplification factors and damping values for railway bridges proposed in en1991 2 2003 and the validity of the deck acceleration limits imposed by en1990annex a2 2005 in both new and existing bridgesinbridge4eu aims to answer these points through the formulation of an enhanced and harmonized method to assess the european dynamic interface between railway bridges and rolling stock the outcomes of this project will provide solid background to the guidance being drafted within the centc250sc1 special group dibrst for dynamics of bridges finally as a consequence the economic outcomes of changing any of the aforementioned criteriaparametersmethodologies in the current european railway bridge landscape will be carefully assessed all the research carried out in inbridge4eu will converge on recommendations to era and cen for revising and updating the current version of the tsis and eurocodes advanced numerical modelling and dynamic analyses of both bridge and railway vehicles together with the development of extensive databases of bridge and rolling stock data obtained from the different partners of the consortium will contribute to the successful achievement of the projects objectives
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visiblelightactivated transmembrane transport by photosensitized isomerization of stiffstilbene based anion receptors
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stimuliresponsive transmembrane anion transport proteins are essential for cellular life due to their implication in important biological functions supramolecular systems with analogous properties have been developed however most of them rely on the use of damaging uv light sensitrans is an ambitious and multidisciplinary project aimed at activation of anion transporters using visible light by means of a sensitization strategy the project focuses on the employment of photosensitizers able to trigger isomerization of stiffstilbene based receptors in the lipid bilayer allowing activation of passive transmembrane transport in addition insertion of the photosensitizer in a vectorial manner into the lipid bilayer will be explored towards lightdriven active transport the project will result in i the development of a new strategy to control transmembrane transport with transformative impact in the field of molecular photoswitches and anion receptor chemistry ii preparation and growth of the fellow towards a fully independent academic career the new scientific research skills complementary soft skills and scientific connections she will acquire will provide her with the necessary competencies to access an academic position at an european institution and iii benefit from her multidisciplinary scientific background and her scientific network by the hosting group
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attosecond photochemistry controlling chemical reactions with electrons
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attop is a theoretical chemistry project that will explore the synergy between the two fields of attoscience and photochemistry chemical processes initiated by light are extremely widespread and their applications cover vital molecular research fields from medicine to computer science and energy conversion however photochemical reactions are limited by the nature and finite number of molecular electronic excited states to overcome this fundamental limitation attop proposes to bring very recent technological progress in extreme ultrashort light pulses attosecond science to the field of photochemistry and to launch the unprecedented field of attophotochemistry indeed light pulses of such short duration have a large spectral bandwidth and excite multiple electronic excited states in a simultaneous and coherent manner this superposition called an electronic wavepacket has a new electronic distribution and is thus expected to lead to a new reactivity the following questions remain for now unresolved what would be the reactivity of a molecule in these new types of electronic states that are becoming accessible experimentally to what extent will the manipulation of an electronic wavepacket produced by an attosecond domain pulse transform the outcome of chemical reactions as an emerging field attophotochemistry requires theoretical support right from the start thanks to the pis unique combination of expertise in both theoretical attoscience and photochemistry the attop team will describe accurately chemical reactions induced by electronic wavepackets via attosecond domain pulses the final aim of attop is to develop a general knowhow to design molecular systems electronic wavepackets and attosecond experiments that transform the outcome of photochemical reactions for diverse applications by doing so attophotochemistry will revolutionize photochemistry with direct impact onto many other domains of molecular science
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applying novel singlecell multiomics to elucidate leukaemia cell plasticity in resistance to targeted therapy
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novel targeted therapies are increasingly applied against a wide range of cancers although such agents can induce cures most patients suffer from relapsed disease acute myeloid leukaemia aml is a prime example of a deadly disease but we have a chance to dramatically improve outcomes if we can better understand resistance mechanisms against targeted agents that are transforming aml treatment such as the bcl2 inhibitor venetoclax aml is characterised by profound alterations in the epigenome that are correlated with poor survival i therefore hypothesise that targeted drug pressure induces epigenetic plasticity that allows cancer cells to sample alternate chromatin or transcriptional states a subset of which confer drug resistance a major challenge is to define how mutations of epigenetic regulators in aml affect therapy responses due to clonal heterogeneity to address this challenge i will use and further develop my recently published singlecell rapid capture hybridization sequencing scrachseq method to link the genotype of expressed genes to transcription and methylation profiles of thousands of single cells in this research proposal i aim to 1 develop a new method linking epigenetic landscape genotype and transcriptome at a singlecell level and define the impact of treatment on these interactions 2 analyse the genomewide impact of epigenetic therapies 3 define the association between drug sensitivity and epigenetic modifications regulating prosurvival genes to achieve my goals i will apply my novel singlecell multiomics to samples from aml patients treated with venetoclax alone or in combination with epigenetic therapies and apply stateoftheart technologies to established laboratory models our new approaches to fully understand the relationship between the genome epigenome and transcriptome will advance fundamental biology this has the potential to yield new therapeutic strategies to prevent and overcome resistance
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flexbased inferring of terrestrial photosynthesis dynamics for quantifying european vegetation productivity
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photosynthesis the biochemical process by which vegetation harvests sunlight to convert carbon dioxide and water into carbohydrates and o2 fuels all life on earth and drives the global carbon cycle although the majority of absorbed light is used for carbon assimilation a remaining part is lost as heat and dissipated as emissions of solarinduced chlorophyll fluorescence sif sif the radiant flux emitted between 650 and 800 nm is therefore the most direct measurable reporter of photosynthetic machinery in plants dedicated to retrieve the full sif signal emitted across the globe esa has selected the fluorescence explorer flex mission concept as earth explorer 8 to be launched in 2024 flex will fly in tandem with copernicus sentinel3 s3 and will operate at ideal spectral spatial and temporal resolutions we are only at the dawn of uncovering the full sif potential from space as so far only a few single sif bands have been exploited the key challenge in the upcoming flex era will be to explore this unique new source of information and link it to photosynthetic activity this proposal named flexinel is determined to take leadership in exploiting and interpreting the forthcoming flex data stream targeting european vegetation productivity and carbon fluxes monitoring given state of the art in plant physiology leafcanopyatmosphere radiative transfer mechanisms machine learning and image processing flexinel seeks to advance the science in consolidating relationships between sif products and complementary s3 vegetation traits thereby uncovering the role of dynamic vegetative and atmospheric variables given a changing earth together with physicallybased modelling latest image processing concepts will be applied such as emulation and cloud computing flex and s3 products will be fed into assimilation systems for quantifying photosynthesis dynamics and into an operational biosphere model for improving europetoglobal carbon flux estimation
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bayesian experimental design for in situ scanning transmission electron microscopy bedtem
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the proposed project bayesian experimental design for in situ scanning transmission electron microscopy bedtem addresses challenges in conducting in situ stem experiments particularly in selecting optimal stimuli parameters while recent advancements in microelectromechanical systems mems have expanded stimulus options determining appropriate values remains elusive often relying on timeconsuming trial and error the project aims to introduce a software platform integrating bayesian experimental design with stem image analysis facilitating efficient parameter selection this platform comprises user interface image processing and experimental design modules offering streamlined workflow and enhanced usability leveraging expertise in machine learning and stem the project seeks to bridge the gap between complex experimental setups and practical application of bayesian methods the envisioned breakthrough lies in transforming offline iterative parameter determination into an online iterative process revolutionizing how in situ experiments are conducted and accelerating materials research and development the project also poses high risks particularly in adapting machine learning to stem data and ensuring market demand for the proposed software however mitigation strategies include iterative development collaboration with experts and continuous user feedback to align the solution with customer needs and commercial viability ultimately bedtem promises to reshape materials science by enabling precise characterization of material behaviors at the nanoscale under realworld conditions with potential applications spanning electronics aerospace and beyond
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algorithmic bias control in deep learning
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deep learning dl has reached unparalleled performance in many domains however this impressive performance typically comes at the cost of gathering large datasets and training massive models requiring extended time and prohibitive costs significant research efforts are being invested in improving dl training efficiency ie the amount of time data and resources required to train these models by changing the model eg architecture numerical precision or the training algorithm eg parallelization other modifications aim to address critical issues such as credibility and overconfidence which hinder the implementation of dl in the real world however such modifications often cause an unexplained degradation in the generalization performance of dl to unseen data recent findings suggest that this degradation is caused by changes to the hidden algorithmic bias of the training algorithm and model this bias selects a specific solution from all solutions which fit the data after years of trialanderror this bias in dl is often at a sweet spot which implicitly allows anns to learn well due to unknown key design choices but performance typically degrades when these choices change therefore understanding and controlling algorithmic bias is the key to unlocking the true potential of deep learningour goal is to develop a rigorous theory of algorithmic bias in dl and to apply it to alleviate critical practical bottlenecks that prevent such models from scaling up or implemented in realworld applicationsour approach has three objectives 1 identify the algorithmic biases affecting dl
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open consortium for decentralized medical artificial intelligence
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artifartificial intelligence ai will revolutionize healthcare as its diagnostic performance approaches that of clinical experts in particular in cancer screening ai helps patients to make betterinformed decisions and reduce medical error however this requires large datasets whose collection faces severe practical ethical and legal obstacles these obstacles can be overcome with swarm learning sl where partners jointly train ai models without sharing any data yet access to sl technology is seriously limited because no studies have implemented sl in a true multinational setup no practically usable implementation of sl is available researchers healthcare providers have no experience with setting up sl networks and policymakers are currently unaware of the broader implications of sl odelia will address solve these issues odelia will build the first opensource software framework for sl providing an assembly line for the streamlined development of ai solutions to serve as a blueprint for future slbased ai systems odelia partners collaborate as a swarm to develop the first clinically useful ai algorithm for the detection of breast cancer in magnetic resonance imaging mri the size of odelias distributed database will exceed all previous studies and odelias ai models will reach expertlevel performance for breast cancer screening thereby odelia will not only deliver a useful medical application but prove the clinical benefit of sl in terms of accelerated development increased performance and robust generalizability to ultimately save thousands of lives of european patients odelias success will push partners to serve as nuclei for the exponential growth of the sl network and extend sl to a multitude of medical applications thus patients healthcare providers and citizens in europe will be provided with a digital infrastructure that enables development of expertlevel ai tools on big data without compromising data safety and data privacy
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regional mobility infrastructures
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remobilise will be the first interdisciplinary study examining the relationship between mobility infrastructures and free movement in west africa in bridging legal studies citizenship studies and infrastructure studies it aims to unpack how mobility infrastructures impact free movement in west africa and with what consequences free movement is recognised as a key driver for economic development poverty reduction and livelihood strategies the economic community of west african states ecowas was among the first organisations to introduce a regional free movement regime in 1979 yet immense disparities continue to exist in terms of who can access this seemingly equal right in practice although studies have indicated that legal technological and physical impediments may result in variegated access to free movement there remains a lack of knowledge on the impact mobility infrastructures have on free movement the project seeks to address this knowledge gap through the study of three complementary work packages focusing on the research questions on manifestations patterns and consequences of mobility infrastructures it will use a mixed method approach innovatively combining ethnographic approaches with legal research and largescale data analysis the project contributes to key debates in legal studies citizenship studies and infrastructure studies specifically by improving the emerging scholarship on mobility infrastructures the findings have direct impact on the lives of over 400 million people living in the region on the work of ecowas policymakers and on external partners such as the un and the eu
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quantum simulator with hot atomic vapors
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in the context of the ongoing development of novel quantum technologies includingquantum sensors quantum communication quantum simulators and quantum computingsome devices are mature without resorting to the powerful but fragile entanglement between qubitsexploiting the wave nature of devices photons often play an important role in order to enlarge thepotential of photonic devices controlled atomphoton interactions will be pushed to new limits in orderto build analog and digital wave simulators in the present projectthese interactions are mediated via photonatom coupling using room temperature cells of atomic vapours
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circular ecological essential critical raw materials
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rotates ambition is to tap the full potential of minerals extraction and processing in a sustainable and ecological way developing the needed technologies and tools for achieving zero emissions and pollution for essential and critical raw materials obtention and ensuring a circular approach by implementing mechanisms for waste valorisation in the context of industrial symbiosis especially reusing waste as aggregates for the construction sector and also recovering secondary productsrotates general objective is to achieve a near zero emissions and pollution obtention of raw materials providing new tools for the mining industry in its journey to a more sustainable and green mineral extraction the solutions proposed in the project will allow to improve the cutoff grade while reducing the environmental footprint of the whole process the pilot demonstrations in mineral deposits with different paragenetic minerals occurring together in a rock formed by the same genetic process during the same stage profiles will ensure the replication of the technologies to a wide variety of mining sitesto ensure eus lead on critical raw materials access the project is structured in three main interconnected pillars providing technical solutions and three transversal floors covering cross cutting issues including clustering and social acceptance a series of technical project results of pillars prp and project results of floors prf will be delivered within the rotates frameworkrotates will deliver specific methods andor technologies aiming to overcome the reluctance of social agents to the exploitation of crm deposits thanks to the environmental impact reduction achieved this will result in an increase of the crm sites that could be exploited in a future boosting the access of eu to strategic crm and enabling the development of the renewables emobility and defence space sectors
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integrated urban food policies developing sustainability cobenefits spatial linkages social inclusion and sectoral connections to transform food systems in cityregions
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europes urban areas face significant challenges to ensure the availability and consumption of healthy affordable safe and sustainably produced food such challenges converge within local food environments but are often neglected by public planners promising initiatives taken by municipalities to change the architecture of food choice often fail to become embedded in the wider policy context and to reach deprived and vulnerable groups key factors responsible for this are 1 siloed ways of working and 2 fragmentation of knowledge on facilitators and barriers related to food system transformation these factors hinder the development and implementation of integrated urban food policiesfoodclic will create strong sciencepolicypractice interfaces across eight european cityregions 45 towns and cities the backbone of such interfaces will be provided by food policy networks which will manage realworld experimental living labs to build a policyrelevant evidencebase through learninginaction activities will be informed by an innovative conceptual framework the clic which emphasizes four desired outcomes of food system integration sustainability cobenefits spatial linkages social inclusion and sectoral connectivities capacitybuilding and direct support for intensive multistakeholder engagement including deprived and vulnerable groups will enable policy actors and urban planners across partner cityregions to develop continuously evolving integrated urban food policies and render planning frameworks foodsensitive results will be communicated and disseminated amongst others by extending the novel policy practices to another eight cityregions in europe and africa an online knowledgehub a highlevel think tank and partners networksin these ways foodclic aims to contribute to urban food environments that make healthy and sustainable food available affordable and attractive to all citizens including deprived and vulnerable groups
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crossplatform open security stack for connected devices
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iot developers face a very fragmented landscape made of very different devices from bare metal devices with few kb of ram and limited or no security protection to devices equipped with powerful support for ai and with builtin hardware hw to implement root of trust rot and trusted execution environments tee such different devices coexist and it is an open challenge to guarantee an acceptable level of security across the whole system to avoid easy entry points for attackers the complexity is further exacerbated by the existence of many hw platforms general purpose but also domain specific each implementing proprietary instances of rot and tee that prevent or make it very difficult for applications and security services to interoperate crosscon aims at addressing all these issues by designing a new open flexible highly portable and vendor independent iot security stack that can run across a variety of different edge devices and multiple hw platforms to offer a consistent security baseline across an entire iot system a highlevel assurance is guaranteed by the formal verification of the stack specifications crosscon stack offers a unified set of trusted apis to the layers above it is modular and among all the security features it offers is possible to configure only the ones needed depending on the underlined hw and firmware it leverages the security features already implemented in the layers below in case such security features are missing like in bare metal devices the stack offers an entire tee implementation suitable for such devices as devices are getting more powerful and use cases more complex there is the need to add new trusted services as building blocks to implement security at the higher levels such as protection of the models given in input to ml engines embedded in hw or support for biometrics and template protections crosscon provides the open specifications of the stack along with an opensource reference implementation
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earth laughs in flowers research training in horticultural precision breeding addressing flower colour as established model
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the colornamental team comprises a promising experienced researcher er in the field of horticulture and molecular breeding and her future supervising team ie an academic beneficiary in austria an associated partner from the commercial horticultural industry in germany and an academic associated partner in germany hosting a 6 month secondment together they have defined an innovative and challenging research project that offers a wellbalanced mixture of research at the interface of fundamental and applied research addressing promising opportunities in the nonacademic sector and scientific hotspots in plant research simultaneously an innovative breeding approach will exploit flower colour as an established model to implement for the first time the use of mad7 nucleases in ornamental breeding and protoplast transformation to modify the bract colour of poinsettia the genome editing approach addresses the substrate specificity of dihydrolflavonol 4reductase dfr and will promote the accumulation of orange pelargonidin based pigments flavonoids including the colourful anthocyanins are the most important secondary metabolites contributing a broad range of physiological functions in plants and humans the latter when consumed as plant derived food this makes them an attractive topic for industry and academia across many research fields the pathway has always served as an important model to establish fundamental scientific knowledge of enzymes gene regulation in plants and a variety of evolutionary processes this will allow the er to augment her expertise with knowledge that is seen as the future of food security while herself imparting a new perspective to her hosts a tailormade training plan composed of scientific key transferable skills elements for public and private sector employment research management presentation and language skills was designed to empower the er to move up the career ladder
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development of the next generation of 3d printed emi shielding solutions based on 2d nanomaterials inks
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with the fast development of wireless communication especially the new 5g technology electromagnetic interference emi shielding is becoming a challenge highperformance emi shielding materials are urgently needed in controlling electromagnetic radiation pollution that seriously affects the normal operation of sensitive electronic apparatus and systems metals are the most used shielding materials but suffer from easy corrosion high density and poor processibility despite the progress most current research still concentrates on the solo enhancement of the emi se to enable new emi shielding applications for nextgeneration devices multifunctionality and low reflection feature are also important for shielding material which can significantly improve the application adaptability and reduce the secondary emi pollution respectively unfortunately most of the present emi shielding solutions cannot simultaneously integrate these characteristics therefore pioneering alternative design and fabrication strategies for developing nextgeneration highperformance shielding materials beyond the usual protocols are urgently needed to meet the escalating demands of modern devices furthermore as a critical component in electronic devices and equipment emi shielding materials also meet great challenges from the miniaturization aspect 2d nanomaterials are promising for emishielding applications due to their outstanding electrical thermal and mechanical properties versatile surface chemistry and their favourable capability to be assembled into macroscopic architectures or serve as conductive fillers for composite fabrication the aim of this project is to determine the economic and technical feasibility of using readily scalable additive manufacturing technologies for the development of highly efficient and customizable emi shielding solutions based on twodimensional 2d nanosheets for electronic applications
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discovering neutrinos of extreme energies with the radio neutrino observatory greenland
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the discovery of neutrinos above energies of 1e16 ev promises to uncover the unknown sources of ultrahigh energy cosmic rays new insights into astrophysics of these sources and particle propagation through the universe as well as new particle physics at energies far higher than those accessible to manmade accelerators the radio neutrino observatory greenland rnog is currently under construction and is scheduled to reach 35 stations in 2026 the inice radio array rnog is the first largescale implementation of the radio askaryan technique and will provide an order of magnitude better discovery sensitivity than existing experiments its construction and operation is led by me and two colleagues from the us and europe this proposal maximizes rnogs potential to discover the long awaited ultrahigh energy neutrinos my research group will do this by enabling highefficiency and highpurity neutrino searches indata through novel simulations with improved accuracy highprecision instrument calibration and the unique exploitation of cosmic ray signals as a training tool
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european researchers night 20222023
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the european researchers night ern in slovakia is the biggest science popularisation event for broad audience taking place every year since 2007 it is established science event that brings interactive programme and science and innovation closer to citizens and ordinary people the ern traditionally takes place in september in unusual places in shopping centres and public spaces innovative formats direct interactions with scientists and informal setting of the project involves hundreds of researchers and it attracts thousands of visitors every year science show within the ern takes place in unusual places shopping centres and an old market hall where it also attracts random visitors and people who normally would not be interested in the topic through an interactive programme it invites visitors to participate in science experiments demonstrations discussions and lectures and provides an opportunity for dialogue and exchange between science community and the slovak society the ern focuses on young people and students and it presents them science and opportunities it provides thus motivating them to embark on research career the science festival appeals to young audience and showcases research in an unconventional and entertaining way
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disruptive communication system based on lifi technology for spacecrafts and aerospace infrastructure
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over the next decade the space industry expects to launch 50000 satellites in orbit however the longterm success of this plan requires substantial cost reductions explicitly to weight and material costs of satellites wired coppered signal harnesses are used for data transmission on communication buses within the satellite and account for up to 10 of the total dry mass of a satellite the high weight density and complexity of the satellite harnesses represent a substantial pain for manufacturers and an opportunity for innovation and market disruption based on feasibility studies with project partners in the space industry oledcomm has developed satellife the first lifi light fidelitybased wireless connection technology which utilizes light to transmit data replacing cables in a spacecraft with satellife allows a simplification of validation manufacturinghuge weight reduction and cost reduction
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safe and reliable combustion technologies powered by hydrogen
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hydrogen is uniquely placed to achieve both energy security and netzero greenhouse emission goals provided it can be produced by lowcarbon resources and systems powered by hydrogen can be operated safely and reliably hydrogen can be burned to produce heat or power it can also be used in fuel cells to produce electricity due to its high reactivity with oxygen it often results in violent dynamics that raises challenges to guarantee the integrity and reliability of the systems powered by hydrogen but also their safety the objective of selecth is threefold 1 develop fundamental knowledge on combustion science associated with the use of hydrogen in real systems 2 develop and validate simulation tools to predict these flows and 3 develop solutions to favor the shift from technologies powered by hydrocarbon fuels to safe and reliable systems only powered by hydrogen these objectives will be achieved in selecth by combining detailed experiments low order physicsbased models and highfidelity numerical simulations in two different sets of configurations with large societal impact the first set considers technologies in which hydrogen must burn efficiently including domestic boilers cooking stoves and gas turbines for propulsion and power generation they cover a wide range of operating conditions fuel and oxidizer injection schemes including laminar atmospheric cases and highlyturbulent flows at high pressure and elevated temperature where combustion dynamics can threaten the system integrity and reliability the second set considers cases where hydrogen combustion must be avoided typically hydrogen leaks from fuel cells or from high pressure storages will be considered to understand how hydrogen leaks may ignite and if they do how they will interact with walls the fundamental knowledge gained in selecth will allow the design of safe and reliable hydrogenpowered units
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system approach to close the employment gap and create a more inclusive labor market for vulnerable groups
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synclusive is an innovative integral and interdisciplinary systems approach to stimulate inclusion of vulnerable groups in the labor market to achieve this our six central objectives are 1 developing and consolidating a coalition of stakeholders in 4 regional living labs across europe along the lines of the community coalition action theory using the engine approach this approach includes an integrated package of interventions that stimulates upward and sideward mobility of vulnerable employees hereby creating vacancies for inflow of vulnerable job seekers 2 testing the usefulness and applicability of the engine approach for different vulnerable groups identified as being discriminated against 3 identifying drivers and barriers for mobility and inflow including discrimination 4 assessing the impact of the implemented engine approach on the labor market mobility and inclusion of vulnerable groups 5 identifying transition pathways from the regional to the national and eu policy level and 6 identifying interoperable and comparative indicators and standards that are relevant for the labor market inclusion of vulnerable groups taking into account the regional national legislative social security and cultural context regional stakeholder commitment as well as the interdisciplinary collaboration is crucial for the success of synclusive and for inclusion of vulnerable people in the labor market synclusive therefore collaborates in an active community coalition amongst municipalities employers civil society and educational institutes which interacts with their political counterparts at national and eu level across 7 european regions synclusive results will lead to sustainable inclusion of vulnerable groups in the regional living labs and have vast potential to result in outcomes far beyond the scope and duration of the project synclusive will contribute to generic and contextspecific euwide policy and intervention recommendations that drive inclusion of vulnerable groups and help to start overcoming discrimination in the eu labour market
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transition to safe sustainable food systems through new innovative detection methods digital solutions for plantbased products derived from new genomic techniques under a cocreation approach
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darwin aims to contribute to a fair healthy safe and environmentally friendly food system by codeveloping an innovative detection strategy by integrating targeted analytical pcrbased methods untargeted sequencing methods and digital solutions a new generation of innovative and reliable dnabased analytical detection methods ranging from enhanced pcr methods for ngt detection identification and quantification in single and multitarget systems to untargeted sequencing methods related to wholegenome sequencing laser capture microdissectionbased sequencing and high throughput metagenomics sequencing for ngt screening and characterization darwin will bring a cuttingedge approach developing genetic fingerprints using artificial intelligence to overcome challenges related to eventspecific targeted methods unambiguously identifying specific ngt lines darwin also brings innovation in the new application of digital solutions such as data spaces and documentationbased screening to increase the data evidence to ngts blockchains to enable transparent and traceable detection along the food chain ai models and a decision support system to improve accuracy and support the selection of the best fit for purpose detection methods darwin will reach trl45 though validation including inhouse transferability and full trials and presenting 3 cases representative of real situations relevant for ngt products in the eu agrifood market after methods validation and the definition of a clear oriented detection strategy darwin will theoretically extrapolate its finding to more complex scenarios encountering the diversity of ngt lines and food products that might reach eu markets all this under an interdisciplinary cocreation ecosystem based on responsible research and innovation rri principals empowering a wide variety of stakeholders including consumers in europe and internationally and robustly contributing to the policy making
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developing and implementing innovative patientcentred care pathways for cancer patients
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in the eu 27m people were diagnosed with and 13m died of cancer in 2020 over 12m people have survived cancer thanks to advances in early detection and new therapies with higher cure rates and more patients living longer with cancer access to patientcentred care consisting of optimal supportive palliative survivorship and endoflife care becomes increasingly important however cancer care still has silos and to this day there is no technical support available that is suitable for different cultures settings and environmentsseveral randomised controlled trials have provided evidence that the integration of patientcentred care in standard oncology care results in better patient and caregiver outcomes as yet these findings have not translated into clinical routinein this project we will develop technologyenhanced and evidencebased patientcentred care pathways called mypath to be merged with tumourcentred treatments across supportive palliative survivorship and endoflife care mypath integrates patientreported outcomes of the ous eir software to be further advanced with contributions of renowned european oncologists ethicists psychologists and sociologists it will be configurated on the ehealth platform of our sme partner dnv imatis its effectiveness and sustainability will be assessed in an implementation science study in 9 clinical centres across europe with the support of leading cancer care professional associations esmo and eapc and the cancer patient organisation ecpc we are committed to delivering the right care to the right person at the right time by the right personswe hypothesise that mypath can significantly improve the quality of and access to treatment and care reduce variations in clinical practice and optimise resources in family community and hospital care settings this will ultimately reduce the physical emotional and ultimately economic burden linked to cancer
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an open access knowledge and data repository to safeguard soils
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more than ever soil health is an issue as recent assessments state that 6070 of european soils can be considered unhealthy the soil deal for europe aims to have 75 of eu soils healthy or significantly improved by 2030 reaching such an ambition requires among others access to reliable harmonised existing and new data and knowledge collected at local national and eu levels to allow informed decisionmaking at all scales to support the soil health law and the eu soil strategysoilwise will provide an integrated and actionable access point to scattered and heterogeneous soil data and knowledge in europe making them fair findable accessible interoperable and reusable and improve trust willingness and ability to share and reuse soil data and knowledge in three project development cycles cocreation and covalidation by multistakeholder groups are the centre of project activities soilwise recognises existing workflows and repositories for specific user needs and aims to work with them to enhance their discoverability approachability and interconnection an open modular scalable and extensible knowledge and data repository building on existing and new technologies will be provided while respecting data ownership access policies and privacy ai and ml techniques will be employed to interlink scattered data and knowledge automatise the processes infer new knowledge and increase fairness soilwise applies infrastructure thinking instead of project thinking to design a repository for at least a decade to support euso evolvement accordinglythe soilwise repository and community are designed to be a joint starting point and common ground for countries the european commission and other stakeholders to jointly guide soil and related spatial policy and informed decisionmaking towards the 2030 goals of the green deal achieve healthy soils in 2050 and ensure broad uptake and implementation by land managers policy research and industry
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finance and innovation to couple negative emissions and sustainable development
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the find project will develop an innovative framework to assess the feasibility and social desirability of limiting global warming through the diffusion of negative emission technologies current global climate action is deeply insufficient to deliver the objectives of the paris agreement and containing global warming to 15 c will likely require the deployment of carbon dioxide removals however the technologies to sequestrate and store carbon from the atmosphere are currently immature risky and highly questioned understanding the effective diffusion potential of carbon removal methods and their socioeconomic and environmental impacts is pivotal to design future climate action the find project aims to ensure that negative emission technologies act as an enabler not a barrier of longrun sustainable development it brings together different disciplines namely climate science economics innovation studies climate finance integrated assessment and agentbased modelling in a coherent and synergic whole find is designed to provide breakthrough evidence about two crucial and underinvestigated aspects of carbon removal solutions i how their technoeconomic paradigms evolve and relate to the broader technological landscape and ii how immature and uncertain technologies can be financed to provide social value rather than speculative interest by combing innovation finance and political economy into a quantitative theory of carbon removal operationalization unfolding at global scale find will expand the stateoftheart in climateenergyeconomy modelling and reassess decarbonization pathways the project will evaluate climate and nonclimate policies to create robust noregret policy portfolios supporting a rapid and sustainable path to a netzero society find will be of high relevance for public policy and civil society especially considering europes commitment to reach carbon neutrality by 2050 while spurring green and inclusive growth
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compact and propellantless electrodynamic tether system based on inspace solar energy
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etcompact is aimed at reaching technology readiness level four for three inspace technologies on the domain of solar energy harvesting and green propulsion the first technology a thin film 2terminal tandem cigsperovskite module with efficiency larger than 15 and a powerperweight ratio larger than 50wkg is called to reduce the cost of inspace solar panels the second technology is a miniaturized target volume 3u greenpropulsion mobility module device based on an electrodynamic tether designed to have tether reelinreelout capability and equipped with a field emission cathode the mobility module can use the harvested inspace solar energy to produce propulsion both thrust and drag without using propellant nor expellant for the mobility module and the satellite platform to host it research on ultralight structures based on 3d printed compliant polymeric techniques is conducted besides mass reduction the goal is to integrate compliance mechanisms for both tether deployment and thinfilm solar panel unfolding the third technology which combines the experience and knowledge of the consortium on photovoltaic and tether technologies is a novel barephotovoltaic tether that uses the metallic tape tether for both electron collection and as the back contact of tandem cigsperovskite modules it integrates in a single device solar energy harvesting and propellantless propulsion project impact is enhanced by activities on market analysis unit mass production and early commercialization solidly supported by simulation work to assess the use of these technologies in the field of post mission disposal active debris removal inorbit servicing and space tugs
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making the invisible visible computational sensing and imaging via folding nonlinearities
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by leveraging a radically new digital sensing approach the cosifold program strives to achieve a quantitative breakthrough in performance while unlocking qualitatively new and previously unthinkable applicationsthe emerging field of computational sensing has opened up new horizons such as the imaging of the black hole however mainstream digital sensing still relies on decadesold ideas from claude shannons seminal 1948 paper which laid the foundations of sampling theory and catalyzed the digital revolution despite immense progress capturing highdynamicrange hdr signals at high digital resolution hdres while maintaining low power consumption lpc remains a significant challenge implementing shannons method via analogtodigital converters adcs introduces fundamental bottlenecks including quantization noise and saturation due to limited dynamic range ldr these limitations are conspicuously evident in cases like the 1986 chernobyl accident where excessively hdr radiation went unrecorded due to ldr dosimeters resulting in loss of lives bottlenecks in current digital pipelines clearly necessitate a paradigm shiftthe cosifold program capitalizes on an alternative methodology that simultaneously unlocks hdr and hdres capabilities with lpc cosifold harnesses a synergistic melding of novel hardware and mathematical algorithms representing the core principle of computational sensing the analogdomain folding of hdr inputs eliminates the wellknown clipping problem while also reducing the quantization noise floor mathematically principled algorithms then computationally unfold the ldr folded samplesthe quantum leap brought by cosifold lies in the comprehensive convergence of theoretical algorithmic and hardware innovations it introduces our feasibility tests indicate the potential to revolutionize the fields of audio and acoustics biomedical and healthcare monitoring and computational imaging which are the focus of cosifold
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a precision medicine trial leveraging bloodbased tumor genomics to optimize treatment in operable stage iii and highrisk stage ii colon cancer patients the sagittarius trial
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sagittarius aim to optimize the clinical management of locoregional stage ii highriskstage iii colon cancer lrcc approximately half of all lrcc patients relapse within two years from time of curative surgery because of imagingundetectable micrometastatic residual disease mmrd given the lack of reliable predictors of individual risk lrcc patients are treated with a onefitsall adjuvant chemotherapy this gunshot approach results in either over or undertreatment measuring circulating tumor dna ctdna in the patients bloodstream can diagnose mmrd retrospective studies show that ctdna detection after surgery predicts cancer recurrence with high sensitivity and specificity sagittarius will deploy a ctdna assay to detect the absence presence or persistence of mmrd in individual patients the diagnosis of mmrd will guide and personalize therapeutic interventions sagittarius is a pragmatic trial whereby realworld patients are treated in two parallel trials based on their mmrd status and the genomic landscape of their tumors ctdna positive patients are randomized to conventional or personalized targeted therapy ctdna negative patients are randomized to a physiciandriven therapy or a waitsee strategy the efficacy and effectiveness of this potentially groundbreaking new strategy of care will be measured via multiple outcomes including safety and time to events variables patientreported outcome measures and healtheconomics evaluation since colon cancer deaths are usually associated with metastases rather than local disease mmrd will also reclassify how this disease is perceived by clinicians this new prism will allow for treatment to be better matched against the tumor biology also allowing for better monitoring via ctdna to assess disease evolution in each patient minimizing harm and maximizing the odds of cure this action is part of the cancer mission cluster of projects on diagnosis and treatment
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era chair in multidisciplinary area studies
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the proposed project eraareas establishes the center for multidisciplinary area studies cemas at the faculty of arts charles university prague cufa under the leadership of an outstanding academic prof mariana llanos eraareas will assemble an excellent multidisciplinary and international research group analyzing the causes and consequences of critical contemporary developments in noneuropean global regions and eastern europe the project fosters international collaboration and enhances cufas research landscape as one of the leading institutions for social science and humanities research in the widening countries prof llanos extensive experience and network will attract toptier researchers invigorating area studies and fostering excellent international research building on multidisciplinarity and a methodologically innovative comparative framework it aims to integrate the disjointed socialscientific and linguisticcultural approaches to area studies in terms of both organization and research cufas global appeal will be amplified through institutional reforms expanded training opportunities and robust networking initiatives eraareas aligns with eu and national strategies enhancing cufas ability to analyze global trends fortify societal resilience against security challenges inform public debates on noneuropean contemporary critical developments through expert knowledge and provide policyrelevant research results for key stakeholders involved in decisionmaking about responses to critical developments around the world leveraging untapped funding potential by strengthening cufas project management and administration the project ensures cemass sustainability bolstering cemas impact beyond the projects duration eraareas will spur the transmission of best organizational and research practices from established area studies research institutions to the widening countries reducing the apparent gap in research excellence
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promoting disaster preparedness and resilience by codeveloping stakeholder support tools for managing the systemic risk of compounding disasters
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the ongoing pandemic and climate crisis have taught us hard lessons about the systemic impact of compounding disasters stakeholders in disaster risk management are faced with the challenge to adapt their risk reduction policies and emergency plans but lack the tools to account for the crosssectoral impacts and dynamic nature of the risks involved the paratus project aims to fill this gap by developing an opensource platform for dynamic risk assessment that allows to analyse and evaluate multihazard impact chains risk reduction measures and disaster response scenarios in the light of systemic vulnerabilities and uncertainties these services will be cocreated within a unique transdisciplinary consortium of research organisations ngos smes first and second responders and local and regional authorities to gain a deeper understanding of multihazard impact chains paratus will first conduct forensic analysis on historical disaster events augment historical disaster databases with hazard interactions and sectorial impacts and exploit remote sensing data with artificial intelligence methods building on these insights paratus will then develop new exposure and vulnerability analysis methods that enable systemic risk assessment across sectors eg humanitarian transportation communication and geographic settings eg islands mountains megacities these methods will be used to analyse risk changes across space and time and to develop new scenarios and risk mitigation options together with stakeholders using innovative serious games and social simulations the results will be hosted on two stakeholder hubs related to crisis management and humanitarian relief and provide stakeholders with a range of tools for risk reduction planning in dynamic multihazard environments the serviceoriented approach with active stakeholder involvement will maximise uptake and impact of the project and help to increase europes resilience to compounding disasters
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strengthening computational biodiversity research in greece
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this era chair proposal has two objectives 1 to set up an interdisciplinary and internationally visible biodiversity computing group bcg at the institute of computer science at the foundation for research and technology hellas icsforth the bcl shall substantially and sustainably strengthen computational biodiversity research and research on computational methods for disentangling molecular evolution in crete with a spillover effect to greece this is motivated by the fact that computational biodiversity research is currently substantially underdeveloped in greece while the area has been recognized as a biodiversity hotspot due to its high levels of spatial temporal and habitat heterogeneity as well as complex geological and climatic history since the late tertiary with an exceptionally high percentage of endemism particularly so on the island of crete it shall generate excellent research outputs with an emphasis on the quality of scientific articles but explicitly not quantity as well as usable and welldocumented open source software for biodiversity computing this will contribute to knowledge generation in the area of computational biodiversity research at a global scale 2 the era chair shall furthermore attract excellent students and researchers from greece and abroad to be trained at and to collaborate with bcg thus the project contributes to foster brain gain and to prevent brain drain at icsforth this is crucial as currently still too many excellent students leave greece for a phd abroad and too few of them return also too few international scientists move to greece from abroad
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co2 removal the technopolitics of negative emissions technologies
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the project analyzes the technopolitics of negative emissions technologies nets in global climate action it is a sociological project inspired by interdisciplinary approaches from science and technology studies nets should mitigate global heating by removing co2 from the atmosphere they not only offset residual emissions to achieve netzero but promise to contribute to netnegative emissions by removing enough co2 from the atmosphere to reduce warming to 15 or 2c after a temperature overshoot though many nets are not yet fully developed prohibitively costly and hard to scale up they already figure prominently in climate scenarios by the intergovernmental panel on climate change ipcc this tension between assigned role and current reality of nets calls for an inquiry that looks at nets as sociotechnical imaginaries jassanoff that shape and are shaped by imagined futures beckert drawing on qualitative social research methods the project will in a first step look at the framing of nets in climate scenarios and ask if and how they justify the delay of climate action in a second step the project will analyze the development of nets in oil and gas companies it will ask how nets allow the companies to envision a future where they can continue their current business model despite stricter climate regulation the project will thus analyze how the mutual reinforcement between calculative devices scenarios and technical devices nets turn nets into attractive climate action options the technopolitics lens the project adopts stresses that these seemingly innocuous devices embody and effectuate political stances that have significant consequences for the direction of climate politics this perspective helps to engender a reflexive discussion on nets that not only narrowly focuses on the costefficiency of carbon removal but also on their effectivity for climate mitigation and their potential contribution to questions of equity
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the microlevel effects of civil wars on multiple dimensions of womens empowerment
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wareffects aims to advance a systematic nuanced and rigorous understanding of how civil wars affect womens social and political empowerment at the local level recent quantitative research suggests that civil wars promote womens political representation but these accounts reflect countrylevel aggregate measures and often focus on a minority of political elite women thus they do not inform us how subnational and individuallevel variation in civil war experiences affect the majority of nonelite women at the local level to address this challenge i propose a novel theoretical framework that simultaneously explores the effects of civil wars on i multiple dimensions of womens empowerment in the household and family the community and local politics moreover i introduce ii nuanced definitions for different types of exposure to civil wars iii the difference between changes in gender roles and gender attitudes and iv the moderating effect of context conditions building on the variation of each of these four dimensions allows me to generate a large set of hypotheses to advance a systematic and nuanced understanding of when why and how civil wars promote womens empowerment and when they do not to empirically explore these hypotheses i will combine novel quantitative survey experiments and qualitative research in colombia dr congo and sri lanka while each country case has experienced several decades of civil war there is significant withincase and betweencase variation in social context conflict dimensions patterns of violence and conflict status rendering them ideal for exploring the local effects of civil war violence on womens empowerment drawing on this comparative design will allow me to make statements about common patterns divergences and conditional effects altogether this wealth of findings will establish a new conceptual and empirical research platform on the impact of civil wars on gender relations
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development and validation of findtb a novel digital tool for tuberculosis triage in children using innovative methodologies and an interdisciplinary approach
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about 5065 of children suffering from tuberculosis tb across all age groups are never detected this contributes to the 250000 deaths from tb in children annually making the disease one of the top ten killers of children under the age of five to improve tb detection in children and reduce tbrelated morbidity and mortality novel diagnostic tests are urgently needed the findtb project aims to address this urgent need by improving case finding at all levels of care in resourcelimited high tb burden settings through the development and validation of an innovative digital tb triage tool that provides individualized tb disease risk predictions coupled with clinical recommendations to guide next steps of care the project will capitalize on digital and scientific innovations that have been successfully applied to the covid19 pandemicstarting with large existing geographically and demographically representative data sets my team and i will develop and validate two predictive models using highly innovative data science methods machine learning and bayesian techniques an app for use by health personnel at all levels of the health care system will be developed for the best performing model to maximize the apps implementation potential i will engage key stakeholders to assess preferences acceptability and feasibility prior to and throughout app development furthermore i will apply humancentered design principles we will then evaluate the designlocked digital tool in a realworld triage use case in a prospective crosssectional diagnostic accuracy study a costeffectiveness analysis of population level impact will round out a dossier that will inform a who reviewthis efficient effective and scalable digital tool for tb triage of children in resourcelimited settings is expected to improve tb diagnosis on an individuallevel and thus tbrelated morbidity and mortality and on populationlevel is likely to improve tb control
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evolutionary origin of cell adhesion the basis of multicellularity in the choanoflagellate choanoeca flexa
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how animal multicellularity evolved from unicellular ancestors remains an open evolutionary question one key prerequisite for the evolution of animal multicellularity was the evolution of cell adhesion however little is known about how cell adhesion evolved in the animal stem in the last decades considerable advances to reconstruct early animal evolution have come from investigations of the closest living unicellular relatives of animals notably the choanoflagellates these microeukaryotes have become powerful models to address the evolution of animals for several reasons 1 they are the sister group to all animals 2 their genomes encode homologs of genes that can inform about animal origins including an animallike celladhesion toolkit 3 they can temporarily adhere to each other and form multicellular colonies and 4 they are amenable to functional genetics therefore studies on choanoflagellate molecular and cell biology can inform the mechanisms of the emergence of multicellularity in animals here i will investigate the cell adhesion mechanisms governing multicellularity in the recently discovered choanoflagellate choanoeca flexa c flexa has direct cellcell adhesion and aggregative multicellularity unique in choanoflagellates and also undergoes lightcontrolled collective contractility of colonies unique in unicellular relatives of animals making it a powerful model to study the emergence of collective behaviors i will perform a systematic characterization of the environmental and endogenous factors regulating cell adhesion during colony formation in c flexa using a combination of genetic engineering biochemistry proteomics molecular and cell biology approaches and functional genomics the data generated here will contribute to converting c flexa into an experimentally tractable species and has the potential to shed light on the premetazoan function of cell adhesion genes
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physical modelling of stellar activity effects to discover and measure exoearths
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exoplanet research has experienced enormous growth and is now pushing instrumental limits to find temperate terrestrial planets and precisely characterise their atmospheres extremeprecision radial velocity rv instruments eg espresso offering 10 cms stability and space telescopes eg jwst ariel attaining relative flux uncertainties of 10 ppm are becoming a reality but there is a shadow of concern hovering over such fantastic performances the intrinsic variability of the stellar hosts can overwhelm the instrument error to become the dominant uncertainty recent results with espresso and jwst data provide vivid illustrations of the daunting effects of such limiting factor an ambitious groundbreaking and comprehensive effort to model and correct out stellar activity effects shall therefore be undertaken our pioneering results show that the unique combination of a physical model and contemporaneous multitechnique monitoring can disentangle the effects of stellar activity from rv timeseries and transit spectroscopy the spotless project will implement this methodology by building a realistic stellar activity simulator and develop correction strategies using eg machine learning algorithms and direct inversion this is more reliable than purely datadriven methods which often suffer from overfitting due to the lack of a physical context four main objectives will be pursued 1 a physical model of the active solar surface to explain sunasastar observables 2 generalise to other spectral types parameters 3 physicallymotivated rv activity corrections at 10 cms and 4 physicallymotivated transit activity corrections at 10 ppm from available and future observations spotless will deliver new challenging exoplanet rv discoveries and unbiased transmission spectra taking exoplanet research to the next level by enabling the detection and characterisation of exoearths and the eventual search for signs of biological activity
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digitalisation and the future of mobility a study of mobility as a service maas platforms
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the project aims to understand the society shaping capacities of digital technologies for mobility investigate their effects on processes of spatial transformation and recognise social and political values that play a role in changing transportation infrastructures and urban travel through investigating mobility as a service maas platforms studying mobility platforms responds to challenges of digitalisation sustainable transformation urban modernisation and social equality the research addresses the gaps in the studies on digital platforms infrastructures and mobilities and responds to rapid sociotechnological changes it contributes to studies at theintersection of digitalisation and mobility justicethe research elucidates how platforms are set to operate objective1 infrastructuring how they interact with existing transportation systems o2 interaction how they reinterpret the role of the usercitizen in the system o3 usercitizen and how they shape future urban mobility o4 mobility futures two maas systems operating in berlin and warsaw will be studied through the mixed methodology including sociological visual digital and mobile methods and techniques such as visualisation and mapping interviews mobility diaries field visits application analysis and workshopsthe results of the project will be published in the form of academic articles and disseminated through workshops lectures and teaching creation of media content with the purpose of impacting mobility transformations for sustainability and increasing role of citizens in digitalisation of mobilityleibnizifl supports the project through its international and interdisciplinary expertise institutional networks and excellent research infrastructure the researcher will achieve academic goals in the areas of research development leadership and international profile and acquire skills and knowledge necessary to take on permanent and leading senior roles in european academia
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timeresolved simulations of ultrafast phenomena in quantum materials
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emergent phenomena arising from excitation correlation and coherence of electrons spin photons and nuclei may open unexplored paths to exploit advanced quantum materials modelling and understanding ultrafast nonequilibrium dynamics is the key to quantum computing to new paradigms for information storage and retrieval to novel optoelectronic devices for efficient light emission and renewable energy production and to efficient singlephoton quantum emitters the times doctoral network will merge different areas of expertise in manybody and timedependent electronic structure methods to define a new paradigm for the atomistic modelling of nonequilibrium processes in condensed matter this is an area where the theoretical stateoftheart is lacking in predictive power on one hand modeling crucial dynamical processes such as the ones involving energy exchange between electronic and nuclear degrees of freedom outofequilibrium remains out of reach for current firstprinciples approaches on the other hand phenomenological and secondprinciples models lack the granularity required to quantitatively capture the evolution of complex materialstimes will develop firstprinciples theoretical and computational tools to tackle the coherent and correlated electronnuclei dynamicsstimulated by ultrafast laser pulses for the understanding of complex quantum states and emergent phenomena in a diverse range offunctional materials like perovskites 2d materials weyl semimetals dirac materials and topological insulators for this purposetimes will train a new generation of scientists capable of devising novel theoretical and computational frameworks to simulatenonequilibrium phenomena times will synergize theoretical and numerical developments with high performance computer centers smes and bigdata facilities across europe the network activities will benefit of synergistic collaborations with leading experimental groups in ultrafast spectroscopy
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a space warehouse concept and ecosystem to energize european osam
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implementing sustainable commercial activities in earth orbit requires not only the key technologies necessary to offer the targeted services oos isam but also the means to effectively ensure the resupply of the associated facilities storage and handling of goods and resources in orbit in support of oos or isam have received limited attention in the perspectives and roadmaps of the major future space ecosystem and economy playersstarfab aims to explore a novel concept of an automated orbital warehouse unit wu within the context of both oos and isam also known as osam commercial perspectives it seeks to address a critical gap in the future space ecosystem serving as an enabler for sustainable osam business modelsthe starfab project will develop a phase a equivalent concept and demonstrator of an orbital warehouse unit wu drawing inspiration from the stateoftheart automated warehousing practices on earth while considering the challenging environmental conditions encountered in space such as microgravity vacuum extreme temperatures and radiation starfabs objective is to advance the necessary technologies for handling goods in space including modular and customshaped components raw materials for manufacturing fuel water and more using robotics and automation this will encompass storage elements with varying levels of protection the items handling solution ihs featuring custom automation tools for operations within the warehouse structure and the item transfer system its designed as a robotic manipulator to provide flexible external item transfer within the wu the starfab concept will also include provisions for robotic inspection and minor maintenance tasks primarily for starfabs own integrity but possibly also as a service for spacecraft docking or berthing with starfabat the end starfab will produce a roadmap outlining the path forward for technology maturation model philosophy market opportunities and subsequent exploitation measures
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datadriven based behavior intervention decisionmaking to ease energy poverty
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energy poverty households face insufficient access to affordable and reliable energy services which can lead to adverse health effects and risky coping strategies the eu made energy poverty a policy priority in the clean energy for all europeans package in 2019 and one of the objectives is to address energy poverty by promoting energyefficient behaviors however intervening in users behavioral decisions is difficult as it requires a deep understanding of the behavior patterns and a rational explanation of the behavior mechanism this project will address a key question in energy poverty research can behavior pattern analytics facilitate the decisionmaking of energy poverty hence the main objective is to assess if datadriven analytics of energy use patterns can provide insight into behavioral interventions to address energy poverty through this project the applicant plans to use three progressive analytics tasks to answer the question i identify the behavior patterns of energy consumption descriptive analytics ii reveal potential cognitive biases that impede high energy efficiency prescriptive analytics iii explore policy interventions against cognitive bias prediction analytics the project will analyze userlevel data through graph data modeling to quantify energy use patterns and behaviors overcoming the limitations of the traditional method relying only on descriptive statistics host and secondment will complement the interdisciplinarity of the project from the perspectives of energy behavior behavioral science and cognitive visualization computer science respectively the project will facilitate the applicants longterm research goals with interdisciplinary knowledge enhancing the development of his career as an independent researcher potential beneficiaries are energy poverty households and energy stakeholders the proposal is in line with the sustainable development goals sdgs and objectives of the h2020 program
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next generation imaging technologies to probe structure and function of biological specimen across scales in their natural context
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the imagine project will develop the next generation of scalecrossing imaging technologies to enable an integrated investigation of structure and function of biological systems it will focus on developing and integrating four major disruptive microscopy technologies namely xray imaging cryo electron microscopy cryo and dynamic superresolution microscopy and large volume intravital light microscopy it will furthermore develop the aipowered image analysis and data integrationsharing capabilities that are needed to correlate these technologies and make their data widely available to harness their power for some of the most pressing societal challenges imagine will prepare its new imaging technologies to be deployed in the field on europes seas and coastlines so that the collection of environmental specimen in their natural context can be coupled with their study by highest resolution imaging technologiesthe imagine technologies are currently at the cutting edge of physics and engineering and therefore only available in isolation and to specialists the project aims to bring them to the european life science user community at large by developing and validating them for service readiness so that they can be provided as future services by europes research infrastructures ris to this end the project will train ri staff on the operation and use of the imagine technologies to promote broad dissemination as commercial instruments imagine will develop technologies jointly between academia and industry promoting open innovation with key instrumentation manufacturers in the imaging fieldthe life science community increasingly relies on ris to access ever more complex and rapidly developing scientific instruments the scalecrossing imaging technologies developed by imagine will be critical to empower groundbreaking research in europe that is so urgently needed to address some of the biggest challenges our societies will face in the future
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a fast numerical solver for electromagnetic compatibility assessment of aircrafts made using nano and micro engineered materials
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the electromagnetic compatibility emc certification methods of aircrafts are predominantly based on experimental testing to fulfill some standard eg do160 this phase involves costly measurement techniques and high rework costs are required when emc weaknesses and vulnerabilities are detected especially at late development stages to alleviate this situation numerical solvers are increasingly considered to complement and support experimental means numerical solvers enable the engineer to address the full complexity of a problem and to better understand the impact of changing key parameters in shielding in this work we will address two challenges currently identified by aeronautic industry first we will develop suitable macroscopic models of novel nano and micro engineered smart materials used jointly with carbon fiber composite cfc ones to be used in fullwave numerical solvers in general and specifically in the finitedifference timedomain fdtd method for this we will start from their microscopic structure to get realistic macroscopic electric and magnetic dispersive isoanisotropic and eventually non linear constitutive parameters second specific subcell models of junctions slots gaps curvatures etc will be devised for their implementation into fdtd to prevent bruteforce simulation approaches of geometrically involved parts of the aircraft otherwise computationally prohibitive as a result the fdtd method will be endowed with the capability of simulating realistic emi problems of a whole aircraft with affordable computational resources in terms of memory and cpu time including cfcs and novel smart materials with all geometrical fine details relevant from the electromagnetic point of view
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scientists from various fields work together for the sustainable development of our planet
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sustainight aims at enhancing engagement with citizens on research and innovation by bringing researchers closer to public at large therefore leading to boosting recognition of science and research education researchers night project covering two editions of night 20242025 will continue the earlier themes although focusing on topics related to sustainable development the motto of the project is scientists from different fields work together for the sustainable development of our planet researchers and public at large will tackle important issues related to the european green deal and the eu missions by bringing the world of scientists closer to people we will gain more interest understanding and appreciation for their work on the contrary revealing research achievements will lead to arouse interest in science among young people and encourage them to take up scientific work all these will be achieved by organisation of two editions of researchers night and researchers at schools initiative together with pre and postevents creating all year long promotion of research careers sustainight is a continuation of the projects of the last 17 years but presents novelties the diversity of projects partners ensures covering wide range of research issues yet complementing each other showing how different fields affect the sustainability of our planet we will show zero waste chemistry ecological vehicles quantum computer will global warming harm us visit the meteorological station ecofriendly consumers and others all these presented in an entertaining way edutainment tailored to wide audience this project aims to strengthen existing ones and shed light on new aspects of science taking into account gender balance inclusiveness in science with a focus on responsible research and innovation we want the researchers night to be a great celebration of science as before
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ships harbouring in ports
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until the emergence of the modern container ship vessels spent a significant part of their lifespan in a harbour the time period when a ship sets anchor in a harbour is key as the entire harbour was designed to offer mooring and all the facilities required for her stay yet a harbour was not merely the accumulation of standings structures made of stone concrete or wood that helped ships make fast in roman harbours associated activities extended beyond their principal basin taking place on a far larger scale and in an agglomeration of different areas than previously conceived by scholars and archaeologists these together constituted a harbour system one of the most significant foundations of ancient economies the projects aims are 1 to identify the various operational parts of harbours 2 to consider how the functions carried out there were combined into a larger area and 3 to consolidate a set of tools that together comprise a unified methodology which can be applied to examples elsewhere beyond these larger concerns the project explores specific issues regarding ships when mooring in harbours what type of vessels did they include what were their needs and what structures could fulfil them did they change according to the different seasons of the year the project comprises an investigation of what we term a harbour system relying on the three case studies of caesarea terracina and portvendres and considers the specificities of each site and their individual environmental context the end goal is that the interdisciplinary methodology developed by our project at the above sites explored within a comparative framework can be later adapted and applied to similar harbour sites elsewhere
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ammonia and mof based hydrogen storage for europe
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ambher ammonia and mof based hydrogen for europe is a european project providing a holistic approach to tackle the short and long term energy storage challenges raised by the high degree of electrification our society is aiming for firstly ambher is addressing the main societal economic and technological questions coming together with the use of green ammonia as seasonal renewable energy storage simultaneously ambher is developing and demonstrating innovative and cheaper compressed hydrogen storage potentially solving the gap toward local and economically relevant powertohydrogen hub ambher will thus increase the number of applications in the energy and transport sectors and the possibilities for success and industrial adoption by key players for shortterm hydrogen storage novel nanoporous mofs metal organic frameworks of high surface area 2500 m2g and low cost synthesis will be developed following an original shaping process 3d printing furthermore ambher will develop a conformable cryovessel that can accommodate stacks of mof bodies of tailoredmade shape a capacity of 40gl of usable space at 100 bar is achieved at competitive cost with respect to current high pressure cylinders 6001000 euroskg h2 for longterm storage advanced materials both catalysts and membranes and their combination in an intensified 3dprinted intensified periodic open cell structured reactor will be developed to allow hydrogen storage in the form of ammonia nh3 in a costefficient and resourceeffective process at lower temperatures and pressures compared to conventional systems ambher project is validating both shortterm and long term solutions at trl 5 addressing the positioning of the solutions developed in relevant business cases the project is built around 16 industry and academic leaders in europe from 7 different countries track record of ambher partners proves the synergies and fruitful collaborative nature among all members
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european key solutions for vertiports and uam
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the eureka project aims at enabling the urban air mobility uam accommodation sesar3 ri need enabling uam in all types of airspace ri need support the development of the uspace regulatory framework and required standards with a focus on the vertiports operations main airports players and uspaceuam developers team up under the leadership of eurocontrol to move the lines and develop the enabling vertiport solutions the project outcomes will trigger a major update of the uspaceuam operational concept with new procedures and tools dedicated to vertiport integration into the airspace the eureka project will develop the complete arrival departure and turnaround process for vertiports the proposed four 4 sesar solutions at trl7 these solutions are essential elements of a process required for integration of vertiports operations into the airspace solution 1 arrival departure to from vertiport including route and trajectory solution 2 vertiport collaborative traffic management solution 3 vertiport disruption and emergency management solution 4 vertiport network flow capacity operational management the eureka project will enable widely accepted solutions that relate to operational procedures and tools usable as a deployable blueprint in all easa members states and possibly beyond by the end of the project the proposed solutions will develop procedures and systems consistent with the regulation when possible and that go even beyond as these solutions will be for manned and unmanned vtol aircraft and not only for uavthe ultimate objective is to deliver eureka outcomes in a way europe can reuse its operational procedures performance and safety requirements validation results recommendations for regulationstandardisation and any information that will accelerate and harmonize the development of uam vtol operations and vertiport development across europe
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