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international political ecologies of land in southeast europe policymaking everyday experiences and alternative political imaginaries
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ipelsee studies the transformations of land use and land ownership in south east europe see in processes of postsocialist transformation different stages and paths of eu integration and the restructuring of global capital flows to do so it approaches land as differently assembled humansoil relations as a policy object an everyday experience and a site of alternative political imaginaries it has two aims 1 to develop an international politicalecology framework capable of studying humansoil relations across multiple scales and 2 to use that framework to better understand transformations in rural and agricultural land use in bosnia and herzegovina croatia and serbia while political science and international relations have focused on issues of power sovereignty and territory they have habitually ignored the humansoil relations that make the land they talk about and the rural areas where those relations are grounded ipelsee is based in three case studies a disputed largescale investment in agricultural land in serbia and two projects that reimagine land use in line with alternative political ecological social and economic ideas a cooperative producing autochthonous grains in bih and an eu funded project for conservation and restoration of dry grasslands in croatia it uses welltrodden methods interviews participatory observation document analysis and innovative methodologies participatory mapping to investigate humansoil relations and their transformations beyond academic contributions to international political ecology within ir interpretive methods in ir and polsci and see area studies communication activities will focus on researched countries to counter the stigmatisation of rural areas and shed light on practices of land use and land ownership that are not only used traditionally but can also contribute to more sustainable and just land use in the future
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advanced biodiversity monitoring for resultsbased and effective agricultural policy and transformation
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unsustainable agricultural practices are major drivers affecting habitat and species diversity in agricultural landscapes of the eu however peatland grassland and species associated with agriculture are of most concern the ongoing negative impacts of unsustainable agricultural practices emphasize the need for a fully integrated approach between the eu 2030 biodiversity and farm to fork strategies supporting the ecs ambition of enhancing biodiversity of agricultural landscapes advanced systems are required to monitor biodiversity features and their changes over time and in space such biodiversity monitoring systems will support implementation of resultbased policies in the european agricultural landscapes the biomonitor4cap project will design advanced biodiversity monitoring systems mainly assessing diversity of targeted species and habitats to be tested calibrated and demonstrated in five european regions representing the major agroecological regions of the eu and one region in peru representing one of the global biodiversity hot spots the project will combine classical indicator systems that are part of the european monitoring framework eg farmland bird index with various indicator systems mostly recently developed and applied in form of standalone systems i new indicator species eg grasshopper ii genetic diversity edna iii onsite sensors eg wing beat frequency acoustic sounds iv functional diversity eg pollinators and iv various spatial measures supporting development and implementation of revised agricultural policies and ensuring rural development the project will involve among multiple stakeholder groups particularly farmers conservationists and service provides as the value andor marketability of public andor private goods delivered through maintained and enhanced biodiversity and related monitoring systems are hardly understood
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the gene therapy coe at the center of portugal
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the main goal of the present project is the creation of a gene therapy research innovation hub rooted in a center of excellence coe located in the centro center region of portugal the genet this coe will capitalize on the already existing rdi capacity in the field at the university of coimbra uc the regional and national pivot of the innovation potential and knowledge transfer in red biotechnology and act as an international enabler of scientific and business excellence in gene therapy innovation and manufacturinggene therapy is the latest revolution in the treatment of severe human diseases with the highest curative and economic potential in the health sector extraordinary results have already been achieved in the treatment of a few neurological ophthalmic hepatic oncological and hematological disorders with outstanding clinical and economic impacts uc notably its center for neuroscience and cell biology has proven scientific excellence in specific areas of the field and a matchless ecosystem to strive in this high addedvalue sector which encompasses the coimbra university hospitals and the biotechnology park biocant recognized as the epicenter of the biotech industry in portugalto achieve its goal the project will teamup with the university of sheffield home of the gene therapy innovation and manufacturing centre a uk pioneer hub dedicated to advancing the clinical development of new genetic treatments and the university of eastern finland which hosts the finish national virus vector laboratory with viral vector gmp production capacity and scaleup key to gene therapy development these two top european institutions are international references in the field at fundamental translational and innovation levelsgenet will thus become a beacon of excellent in gene therapy ri with enormous impact in the decrease of mortality and suffering while contributing to the economic recovery and growth of portugal and the eu
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plasmodium liver stage schizogony high replication and genetic diversity
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a world free of malaria is certainly a desirable goal however in spite of the significant incidence reduction achieved globally between 20002015 malaria still kills a child every minute the limited understanding of plasmodiums biology hampers the development of novel intervention strategies upon transmission by anopheles mosquitos plasmodium parasites must reach the liver and infect hepatocytes inside a hepatocyte each parasite replicates into thousands of new erythrocyteinfectious forms which lead to disease the parasite biomass generated during the liver stage ls of infection is directly associated with malaria severity but how the parasite achieves such a high replication rate and the consequences of that remain utterly unexplored notably plasmodium replication is unusual the parasite divides by schizogony with divisions occurring without cytokinesis and it cannot salvage pyrimidines from the environment relying solely on nucleotides synthesized de novo using a plasmodium transgenic line specifically designed to study dna replication throughout parasite development i unveiled for the first time the temporal dynamics of dna replication throughout parasite ls and show that plasmodiums ls high replication rate is accompanied by dna damage thus i hypothesize that dna damage accumulation during ls schizogony is a generator of genetic variability prior to intraerythrocytic infection by using a combination of molecular cell biology and genetic approaches i now propose to characterize the mechanisms define the molecular players and reveal the causes and consequences of such a high replication rate in the outcome of infection and progression of disease by exposing the consequences for parasite genetic diversity and virulence connecting ls schizogony with parasite genetic diversity and virulence for the first time will be conceptually transformative and will certainly provide valuable targets and tools for the combat against malaria
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strategies for the evaluation and assessment of ocean based carbon dioxide removal
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seao2cdr is an ambitious multidisciplinary project that unites expert scientific economic legal political social and ethical researchers with industry leaders and regulators to establish and assess the evaluation pathways and methodologies required for sustainable and effective operationalisation of oceanbased carbon dioxide removal ocdr the implementation of appropriate cdr strategies is regarded as an essential component of most net zero emission pathways yet the mechanisms and processes needed to facilitate their deployment remain largely unexplored notably ocdr approaches have generally received less attention than terrestrial cdr technologies despite offering equivalent or greater sequestration potential seao2cdr addresses critical gaps in our technoeconomic understanding of archetypal ocdr approaches in order to define the operational spaces in which they are environmentally and economically viable and will establish robust monitoring reporting and verification mrv strategies for different approaches using stateoftheart earth system models esms and autonomous sensor technologies stakeholderoriented governance frameworks will be developed that define the multidimensional interaction points through which responsible and effective governance of ocdr could be implemented and support the business development and investment needed to scale up ocdr finally the parameterisation of ecological synergies and systemlevel tradeoffs will enable ocdr to be incorporated into integrated assessment models iams that identify which techniques are best positioned to support the transition to a climateneutral and resilient society together these activities will enable seao2cdr to advance the implementation potential of ocdr by supporting the characterisation and development of environmentally safe socially acceptable and economically viable approaches that can help realise global climate policies
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multiomic data driven drug discovery and indication prioritisation platform in oncology
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with 20 of patients responding to their treatment and 10m dying every year cancer is a recognised societal challenge while datadriven approaches can double the clinical trials success rate the pharma industry lacks tools to leverage the large amount of data generated in their drug discovery processeswe are developing mcube an aipowered platform that scales precision oncology for drug discovery and repurposing bestinclass and usercentric platform mcube encapsulates a canceragnostic clinical data harmonisation module with an integrative approach to multiomic data analysis as our solution increases in value and allows us to move up the value chain our initial saas business model will progressively switch to a drug discovery model with mcube we will identify and validate new drug candidates to license ip assets to pharma companies by 2025 we expect to sign a deal of 25m with a biopharma partner we will disrupt he oncology market for the benefits of cancer patients
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conjugativekiller plasmids a novel antimicrobial alternative
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targeted killing of pathogenic bacteria without harming beneficial members of the host microbiota holds promise as a strategy to cure disease and limit both imbalances in the microbiota and development of antimicrobial resistance recent work from the unit de plasticit du gnome bactrien has demonstrated that genetic modules based on toxinintein systems delivered by conjugation are highly effective antimicrobials agents able to selectively kill vibrio cholerae in mixed populations in this line of work the project described in this proposal aims at adapting the aforementioned system to other pathogens of clinical importance salmonella spp shigella spp and klebsiella pneumoniae by including new toxin modules whose expression depends on transcriptional factors that are exclusively present in the targeted bacteria additionally to ensure an efficient dissemination and maintenance across the microbial gut population we intent to engineer conjugative plasmids to be transferred and maintained between enterobacteriaceae and bacteroides one of the main constituents of the gut microbiome once validated under laboratory conditions the system will be assayed in a caernorhabditis elegans model either with the aim of eliminating a specific pathogen causing disease or as a probiotic agent against pathogenic colonization the results obtained from these preliminary tests will direct the refinements needed for the generation of an effective tool against antimicrobial resistant pathogens in a real scenario
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understanding neutral weed communities crops interactions and identification of artificial intelligence algorithms for speciesspecific weed management using robots
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the overarching objective of neutraweed is to form an international and intersectoral network of 16 organizations in four continents europe africa asia and america working on a joint research program in the fields of weed ecology and management artificial intelligence ai and robotics new sustainable weed management solutions are requested since the overreliance on chemical control and intensive tillage in oversimplified cropping systems are now questioned because they have many drawbacks as a solution we propose the promotion of neutral weed communities nwcs which are weed communities that can coexist with the crops without reducing crop yield or quality compared with weedfree conditions in this 4yer research plan we propose to 1 identify nwcs in diverse cropping systems and study their interactions with crops and other biotic agents 2 investigate their effect on ecosystem services provision 3 develop weeder robot prototypes for weedspecific analysis 4 identify ai algorithms for weed speciesspecific discrimination to test on robots to attain nwcs a multidisciplinary and intersectoral approach will be used to comprehend the multiple interactions between weeds and crops under four aspects agroecological physiological molecular and microbiological using weed species images ai algorithms will be developed and tested on autonomous robots to attain nwcs by selectively removing only highly competitive weed species while leaving only the beneficial ones the staff members will develop new skills and competencies will be exposed to new research environments and will have their career perspectives broadened neutraweed will advance research by fostering the interconnections among countries providing training and education at academic and technical levels and engaging with local national and international stakeholders to create shared knowledge on weedcrop interaction and new sustainable ai technological solutions to manage weed
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design and evaluation of technological support tools to empower stakeholders in digital education
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given technological developments in other domains and lessons from the pandemic there is a strong push to invest in technologyaugmented education however much remains unknown for example what technological abilities are useful in education how they can be deployed what training needs arise and what shape future policies governing this should take empower contributes to resolving these questions by developing novel technological support for the education of children with neurodevelopmental disorders ndds this use case is in many ways challenging and thus ideally suited to 1 make a positive impact on the educational needs of these children and 2 highlight the potential and limitations of technologyaugmented education in a way that can inform future developments generallyndds affect approximately 15 of children aged 3 to 17 years these children can experience difficulties with language and speech motor skills behaviour memory learning or other neurological functions and benefit from education tailored to their needs empower creates a novel platform based on new paradigms from psychology that suggest that executive function ef and emotional self regulation are two key sets of skills to target in the educational intervention for these students the core output of empower is thus an educational platform cocreated by all involved stakeholders that facilitates the improvement of these key skills in children with ndds the platform will be tested and evaluated in school settings with all stakeholders involved according to the strict standards of a randomized clinical trial in addition to technological advances the lessons learned from the development and deployment of this platform will provide valuable insights into the needs and possibilities for training teachers in the use of new technologies as well as input into future policies governing technology in education including in particular refined ethical frameworks
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early multiomic cancer assessment emoca
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lung cancer is a leading cause of cancer related mortality claiming an estimated 18 million lives in 2020 in the eu lung cancer accounts for 12 of all new cancer diagnoses and 20 of all cancer deaths although helpful in identifying earlystage lung cancer screening programs frequently lead to falsepositives and overdiagnosis this is exacerbated by a lack of clinically useful biomarkers to accurately differentiate between lung cancer and indeterminate nodules found in the lung recent studies on lung adenocarcinoma luad suggest that microbial and host genomic signatures could be leveraged to develop useful biomarkers in earlystage disease however these studies are based on systemic signatures identified using metagenomics in plasma rather than at the site of the disease the lung very little research has been done on lung squamous cell cancer lusc it is likely that both microbial and host signatures in the lungs of patients with lusc a more centrally located cancer will be more specific and have stronger predictive power as biomarkers sampling of the lung is difficult however and involves invasive procedures such as bronchoscopy exhaled breath condensate ebc is a novel noninvasive method of collecting lower airways samples which i will use to evaluate the lung microenvironment in lusc furthermore microbial rna sequencing metatranscriptome provides broader and more detailed insight into the active function of microbes in different environments while metabolomics provides further insight into the byproducts of microbial metabolism applying this unbiased omic approach metagenome metatranscriptome metabolome transcriptome to multiple sample types blood sputum ebc bronchoscopy samples will allow identification of novel microbial biomarkers capable of distinguishing between lusc and nonmalignant nodules and predicting lusc progression and may help guide the development of new targeted treatment approaches in lusc
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the first european scalable ultracheap and easily deployable longduration energy storage solution based on iron water and air the missing link to accelerate the eus energy transition
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ore energy is a climate tech company developing ultracheap longduration energy storage systems based on very abundant materials iron water and air born at tu delft our technology is fully patent protected and has won multiple awards eg sprind longduration energy storage challenge nwo faculty of impact thematic technology transfer etc after several years of multidisciplinary research we have overcome the bottlenecks that have blocked for decades the commercial development of ironair flow batteries the result is amazing compared to other stateoftheart electrochemical storage systems such as liion batteries our batteries can supply energy for days instead of just a few hours at an unbeatable cost they are totally free of critical raw materials and their materials are easily recyclable plus the technology is completely safe without any risk of fire besides they are also the only truly scalable batteries thanks to the noncritical raw material usage and employing streamlined manufacturing methods we can easily scale their production without risks of supply chain outages or volatile prices in addition thanks to their fully modular plugandplay architecture packaged in a container our batteries can be deployed anywhere and at any scale our ambition is to close the technological gap that continues to hold back the massive deployment of renewables to accelerate the eus energy transition and at the same time increase the europeans competitiveness while guaranteeing its energy sovereignty
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observational cosmology using large imaging surveys
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the current standard model of cosmology successfully describes a variety of measurements but its main ingredients dark matter and dark energy are a great mystery esas euclid satellite is the biggest step forward towards solving this fundamental problem in physics it is designed to reveal the nature of the dark constituents and gravity by measuring the growth of structure over most of cosmic time with unprecedented precision but the interpretation of the data is complex incorrect modelling of the galaxy populations astrophysical processes or instrumental effects can easily be mistaken as evidence for new physics to fully exploit the statistical power of euclid the intricacies of the data need to be understood but we also need an accurate model of structure formation that can describe the interplay between galaxy formation astrophysics dark matter and cosmologyoculis tackles both aspects by providing the best measurements of the lensing signal and using the euclid data in novel ways to relate observed galaxy properties directly to the matter distribution to do so we will i use inflight data to correct for instrumental biases ii measure the intrinsic alignments of galaxies that contaminate the lensing signal iii exploit euclids unique ability to determine the lensing signal on small scales to directly determine the stellar masses of galaxies for the first time and to study the tidal stripping of dark matter halos iv use the results to inform models that describe the smallscale astrophysics in hydrodynamic simulations yielding robust predictions of the cosmological signals as cosmology coordinator of the euclid mission the pi is uniquely positioned to achieve these objectives the synergetic approach of oculis exploits that euclid is much more than a cosmology mission it is also a prime dataset for the study of the formation and evolution of galaxies by linking both science cases oculis maximizes the scientific return of euclid
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biobar biological barriers for a sustainable landfill design
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waste management and final disposal cause severe environmental impacts even in modern landfills installed engineered barriers worsen their hydraulic performance after 8 years of landfill operation which can lead to leachate leakage and environmental pollution in the medium to long term in addition the use of clay as landfill barriers relies on a nonrenewable resource and entails high economic and environmental costs when such a resource is not locally available therefore it is necessary to develop barriers made of renewable andor recycled sources which not only promote leachate containment but also enhance its insitu treatment and attenuation this project will take advantage of the bacteria naturally occurring in leachate that grow and form biofilms by consuming the organic compounds we will apply the biofilmforming bacteria in a novel liner made of the rejected fraction of fine aggregates and plastic waste adopting such a biobarrier between the liner and the drainage system could reduce both the leachate flow and the contaminants concentrations that actually reach the liner this is because the natural clogging of the biobarrier would reduce its permeability and the physicochemical and biochemical processes would enhance their attenuation in this regard the proposed project will 1 develop biobarriers for landfill design combining the rejected fraction of fine aggregates plastic waste and biofilmforming bacteria 2 verify the longterm performance of these new designs for representative conditions and 3 develop guidance for realworld implementation to reduce barrier permeability and increase contaminant attenuation the biobarrier biobar approach has not been quantitatively tested for landfill barrier design and merges innovative geochemical concepts and biofilm engineering the effectiveness of the developed biobarrier could enable the reduction of clay liner thickness in a renewable and sustainable design perspective
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supporting european ri through stakeholder collaboration and institutional reform
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initiate is a project that aims to empower higher education institutions to develop ri through institution transformation initiate in its widening dimension seeks to raise excellence in science and knowledge valorisation of europes universities through cooperation and knowledge circulation through stakeholder inclusion and codesign approach initiate will design an approach for institution transformation that will reflect on the current needs and resources of the institution external elements such as policy barriers good practices from other initiatives and identification of possible collaboration areas with other institutions including local ecosystems through iterative process and ri labs supported by online tools such as knowledge hub initiate will generate policy recommendations for helping stimulate ri development and scientific excellence in widening countries in addition to research outputs and creation of joint applications for other funding sources eg horizon europe the approach will be demonstrated in croatia portugal and north macedonia this will finally result in a roadmap for long term uptake of ri in widening countries with identified replication cases and forming of the alliance for green energy transition that will assure the longterm sustainability of initiate results the action focuses on universities in widening countries in which the cases for the implementation of initiate approach will be conducted additionally the project aims to achieve several outcomes including the successful institutional reform and upgrade of higher education institutions in the ri dimension empowerment to be actors of change and the mainstreaming of a culture of excellence in science and value creation amongst higher education institutions particularly in less researchintensive institutions and countries to achieve these outcomes the project will engage universities as well as local ecosystems
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heritage of disease the art and architectures of early modern hospitals in european cities
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after the black death of 1348 hospitals were newly designed to face social disease further plagues waves and new illnesses eg syphilis social distancing like recently with an unknown virus was the main method to avoid all kinds of contagion new spatial and safety concepts were developed to care and confine the sick and the poor in structures enhancing the visibility of political or religious agendas while wars and early globalization contributed to spreading pandemics charitable bodies exploited their roles to gather capital which they reinvested in art despite an extensive scholarship on hospitals as social institutions the question of why art and architecture were so vital for hospitals remains open archiater tackles this gap focusing on three objectives 1 to map hospital visual cultures agencies and imaginations in european cities before 1750 along terrestrial and maritime routes and according to hospital typology and networks 2 to analyse the spaces forms themes and designs of hospital art and architecture as liminal mediators to manage disease and contagion as well as life passages healing death and salvation 3 to reconstruct transitions and changing values of hospital materiality and develop ways of curating the impressive heritage of premodern hospitals bringing together art architecture history and curatorial studies the project looks at these relations in comparative and interconnected ways it combines geographical and microhistorical investigations objectbased analysis and a new conceptual questioning on the liminality of hospital art and architecture as mediators between spaces actors and intentions in the monumentalization of disease which characterizes historical cityscapes addressing these issues will reveal not only why so many artworks in our museums come from hospital contexts but also how visible artefacts can contribute to the wellbeing of a society faced with invisible threats
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elem virtual heart populations for supercomputers
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elems vheart is a supercomputerbased platform to perform massive insilico clinical trials on populations of digital avatars generated through a database of real medical data to study the outcomes of different therapies it assesses the safety and efficacy of novel therapeutics devices or drugs by computing thousands of scenarios current capability covers classic or leadless pacing and cardiac pumps and cardiac safety of drugs our plan is to add new therapies whilst increasing the range of our patented virtual population technology vheart generates unparalleled medical insights and new evidence for biomedical professionals whilst shortening time to market and reducing business and patient risks it narrows the scope for animal testing and tapers real human trials by evaluating clinical study endpoints much faster and earlier in the development process eventually digital avatars become a digital twin of any given patient used as a predictive tool for precision medicine
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fuel forming electrocatalysis devising multifunctional covalent organic frameworks with vinylenic linkage for electrocatalytic co2 reduction and water oxidation
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global energy demands and increase in the utilization of fossil fuels have contributed towards rising co2 concentration in the atmosphere giving rise to grave environmental concerns such as the green house effect in order to achieve decarbonization of the energy system the european green deal considers the development of innovative technologies as the one contemplated in this project as a key point generation of chemical fuels by mimicking photosynthesis is a promising technique the significance of plant photosynthesis to convert co2 with h2o into carbohydrates and o2 by sunlight in a green manner is widely known artificial photosynthesis is expected to efficiently mimic this process for reducing co2 with h2o as electron donor that is integrating co2 reduction reaction co2rr and h2o oxidation half reactions in one catalytic system electroreduction of co2 into valueadded fuels is of significant importance but remains a big challenge because of poor selectivity low current density and large overpotential crystalline porous covalent organic frameworks cofs are promising alternative electrode materials for co2rr owing to their tunable and accessible single active sites this proposal aims at introducing a new class of cofs based electrocatalysts to rationally explore the use of heterogeneous electrocatalysts offering both chemical tunability and stability in harsh reaction conditions the development of an electrocatalytic model system is proposed herein which will be meticulously executed via strategic synthetic protocols and optimized by solidstate chemical procedures and crystal engineering so as to provide insights into the architecture of the cofs reactive intermediates and mechanistic steps involved in the electrocatalytic process
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political art understanding the function of art in the contemporary social space through a new interpretation of classical german philosophy
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polart intends to rethink the relationship between art and politics it will answer the questions of what the political dimension of art is and what art can give to society the general aim of polart is to understand how art can play a central role in determining the fundamental ideals of a society acting as a significant way to know understand criticize and transform reality both epistemically and practically polart will produce a new hermeneutic model to investigate the relationship between art and politics rethinking a decisive historical moment in its construction in order to address the current situation it will explore the origins of the contemporary view on the topic in classical german philosophy as the first real moment in which this relationship is conceived philosophically on the one hand the current debate on the artpolitics dichotomy still has as its main frame of reference the 20th century discussions which remains dominant and obscures the relevance of classical german philosophy on this topic on the other hand critical literature on classical german philosophy has not yet explored the topic with a sufficiently unified and comprehensive view thanks to a methodology that combines distance reading and conceptual history in an original way polart aims to fill this gap by developing a new interpretive paradigm derived from an innovative interpretation of classical german philosophy which can genealogically show its fundamental value for subsequent discussions and produce a reflection on the issues of todays debate in addition to the innovative scientific results expected in the fields of classical german philosophy studies and aesthetics from a more general point of view polart will philosophically show how art can be a decisive element for the construction of a political community and for the formation of an active and conscious citizenship for individuals
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advanced nuclear safety evaluation of liquid metal using systems
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the importance of low carbon energy sources in the efforts against rapid climate change makes nuclear energy part of a sustainable energy mix although there have been years of experience feedback with water cooled reactors fundamental improvement particularly regarding intrinsic safety and reduced nuclear waste generation is possible using advanced nuclear designs heavy metal cooled systems such as the lead fast reactor lfr combine the advantages of a fast reactor system that reduces waste with the intrinsic safety related properties such as the high boiling point chemical inertia and improved heat transfer anselmus responds to the horizoneuratom 2021nrt0102 call safety of advanced and innovative nuclear designs and fuels its objective is to contribute significantly to the safety assessment of heavyliquidmetal hlm systems in particular alfred and myrrha as these are included in the roadmap for the development of advanced systems in europe it will use the maturity of both designs to create two detailed phenomena identification and ranking tables pirt that identify all verification and validation needs and are used for further safety evaluation the project will also experimentally validate key safety related subsystems including the safety rods failed fuel pin detection and the coolant chemistry control system we also will improve the validation of numerical models describing the fuel assembly through experiments and simulations and work on reactor safety monitoring and inspection of hlm systems focusing on high temperature vessel inspection moreover anselmus will look into the societal impact of hlm reactors by assessing the integration of lfr in a mixed energy landscape including economical aspects and by addressing social and ethical considerations of advanced nuclear technologies finally a dedicated effort will be put into education and dissemination towards all stakeholders including policy makers and the general public
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datadriven residential energy carrieragnostic demand response tools and multivalue services
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dedalus will design develop and demonstrate sshdriven multivalue energy carrieragnostic micro homeapartmentto macrobuilding districtscale participatory demand response dr ecosystem aimed to a facilitate and scale up residential energy consumers massive participation to dr b adapt to a variety of different monocarrier electricity heat or multicarrier synergetic scenarios electricity vs heat and natural gas at buildingdistrict scale while strengthening social interactions within respective communities to this aim we will deploy 1 a social science framework for multidimensional incentives and nudging interventions tools 2 aibased individualbuildingdistricts consumers clustering and segmentation algorithms 3 open apis for drready smart appliances 4 energy dataspace adaptation for extended dr interoperability and privacypreserving dltblockchain data governance and flexibility coordination 5 digital twins for consumersaware dr flexibility planning 6 comfortbased flexibility models and tools for serviced apartments for elderly people 7 flexibility management tools for building and physicalvirtual districts energy communities based on preaggregation and shared dr assets 8 optimal aggregation of flexible energy assets for district heating and decentralized power2heat 9 business sandbox with novel sharing economy social innovationbased business models dedalus solutions will be validated by 5 front runners fullscale pilots and replicated by 2 multipliers in 7 countries deployed at the interplay of energy and nonenergy comforthealthcare ageing social innovation sectors and operated by different stakeholders social housing operators building operators aggregators energy communities retailerssuppliers dsosdistrict heating network operators capacity building and blueprints will support policy makers and regulators to enable market takeup and euwide replication of residential dr
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demonstrating and connecting production innovations in the biomethane universe
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biomethaverse demonstrating and connecting production innovations in the biomethane universe aims to diversify the technology basis for biomethane production in europe to increase its costeffectiveness and to contribute both to the uptake of biomethane technologies and to the priorities of the set plan action 8 to this aim five innovative biomethane production pathways will be demonstrated in five european countries france greece italy sweden and ukrainethe project is based on the following founding pillars demonstration of innovative biomethane pathways technology optimisation and upscaling by technoeconomic flowsheeting environmental and social sustainability assessment replicability market penetration support to planning decisions of other investors and project developers policy recommendations to policy makers dissemination exploitation and communication of project resultsbiomethaverse relates within the work program 20212022 on climate energy and mobility to the call sustainable secure and competitive energy supply specifically to the topic horizoncl52021d30316 innovative biomethane production as an energy carrier and a fuelthe project production routes cover one or a combination of the following production pathways thermochemical biochemical electrochemical and biological as a starting point four demonstration plants use conventional anaerobic digestion ad and one uses conventional gasification in the biomethaverse demonstrators co2 effluents from ad or gasification and other intermediate products are combined with renewable hydrogen or renewable electricity directly to increase the overall biomethane yield all demonstrated production routes go beyond conventional technologies with a circular approach for energy and material while aiming at reducing the overall biomethane production costs and increasing the biomethane production the demonstrated technologies will reach trl 67 at the end of the project
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multiscale modelling for wind farm design performance assessment and loading
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the wind industry is developing wind turbines and airborne wind energy devices which span altitudes well above the wellstudied surface layer a full understanding of the unsteady inflow conditions which drive loads and performance at these altitudes is lacking meridional will provide a comprehensively validated tool chain based on an opensource platform which will draw on an integrated knowledge and data hub to allow the efficient and accurate assessment of the performance and loads experienced by onshore offshore and airborne wind energy systems this tool chain can be used for component device and plant level planning and operation it will consist of models which can capture the unsteady timeresolved inflow structures which drive performance and loads within the wind plant incorporating inter and intra farm turbine interactions inflow conditions will be analysed and modelled beyond the surface layer to capture the conditions within and above the atmospheric boundary layer this is critical to a full understanding of the loads and performance of wind farms and airborne wind energy devices model validation will be underpinned by a range of high quality and unique datasets drawing on highfidelity simulations and kiteborne lidar drone and mast measurements from field test campaigns in complex terrain offshore and airborne the strength of the tool chain results from developing different models for different situations using higher order approaches eg meso and microscale les when required and lower order models physics or datadriven where these are sufficient to accurately predict loads and performance the knowledge and data hub will allow users of the tool chain to draw on a wide range of existing and projectgenerated measurement and simulation data to allow site specific analysis to be carried out at any location meridional allows stakeholders to increase wind plant efficiency and reduce material costs through less conservative design
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mobile primary care device for documentation and analysis of chronic wounds market transition
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more than 12 million people worldwide suffer from chronic wounds these open wounds need to be treated in the long term resulting in annual costs of 27 billion the treatment of chronic wounds is based on recurring medical examinations at intervals of 4 weeks which include photographic documentation and a measurement of the wound according to the current state of the art this is simply done with a ruler whereby the ruler is often inserted directly into the wound to assess the depth of the wound this method not only leads to unreliable and nonreproducible results it also takes up to 30 min and is associated with massive pain for patients to provide patients with relief and efficiently support wound healing curevision has developed a unique primary care device that enables fast and accurate documentation and analysis of chronic wounds our device contains multiple cameras and detectors that fully automatical analyse seven critical parameters without touching the wound itself in addition to the wound dimensions the integrated ai also automatically and reliably analyses the tissue components of the wound thus for the first time our mobile primary care device enables fast and accurate assessment for every wound to enable clinicians to adjust the therapy early in addition to the significantly more comfortable noninvasive examination for the patient our device reduces the examination time by up to 60 the optimised therapy will reduce both treatment time and hospitalisation rates resulting in annual cost savings of over 40 million in germany alone after producing a first working mvp we now want to produce 50 final mvps to test and verify the functions under real conditions and make adjustments based on user feedback before we go to market our device must be approved as a medical product in addition we will set up a reliable data protection management system these final steps are to be achieved within the outline of the present project
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gathering expertise on vibration impakt in nuclear power generation
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the gathering expertise on vibration impakt in nuclear power generation goviking project takes over from the viking initiative that started in 2020 as an inkind collaborative effort of european vendors utilities technical safety organizations universities and research organizations to improve the understanding and the prediction of flowinduced vibration fiv phenomena relevant to nuclear power reactors preventive measures against fiv should be taken in the component design and during the operation of the nuclear steam supply system nsss to avoid structural wear damage or even incidental or accidental scenarios with potential radioactivity release to the environment the overall objective of goviking is to increase the expertise and improve the tools and skills of the european nuclear stakeholders for the analysis of complex fiv phenomena in order to maintain and enhance nuclear plant safety this will be accomplished by generation of highresolution numerical and experimental data of fiv in single and multiphase flows development and validation of high and mediumresolution as well as fastrunning practical tools for the fiv analysis implementation of efficient methods for uncertainty propagation in the fiv results synthesis of best practice guidelines for fiv analysis in accordance with the needs of the stakeholders targeted training of graduates and young experts as well as practitioners from stakeholders in fivrelated phenomena and modelling techniquesthe goviking project will improve the safety of contemporary reactors and the design evaluation of new concepts by making available new experimental results and improved numerical approaches for the evaluation of fiv these will allow the nuclear operators to enhance the prediction of fiv phenomena in key nsss components and the vendors to improve the design of the relevant equipment thus leading to increased reliability availability and safety of the european npps
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phase diagram of multiprincipal element alloys
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multiprincipal element alloys mpea have emerged as a novel class of materials with broad potential applications in engineering fields due to their unprecedented properties the phase diagrams essential for designing these alloys have been traditionally obtained through costly experiments and calphad calculations based on semiempirical functions in this project a novel methodology is presented to determine the phase diagrams of mpea by combining the first principles calculations and the calphad methodology the strategy is based on two main pillars firstly first principles calculations based on density functional theory in combination with the cluster expansion formalism and monte carlo simulations will be used to determine the gibbs free energies of binaries and ternaries alloys including the contributions of configurational vibrational and magnetic entropy secondly this information will be used as input to create thermodynamic databases that will be used to predict the phase diagrams of mpea following the calphad methodology this strategy will be demonstrated in nicrco and nicrcofe mpeas the approach developed in this proposal will provide a roadmap to calculate accurate phase diagrams of any mpea a fundamental step to optimize the performance of these alloys and accelerate their introduction into the market the applicant will transfer her expertise and international connection in the field of thermodynamic modelling through calphad to the host institute she will work with researchers of the host institution to prompt new areas of research that can attract new funding and receive regular training on transferable skills all these activities will enlarge her portfolio of skills and will ensure further development of her career
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unveiling the infancy of planetary systems
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observational campaigns are revealing that planet formation is an extremely efficient mechanism and that at the same time it leads to a wide diversity in exoplanet properties while high resolution images of protoplanetary disks show potential signatures of planetdisk interactions an observational characterization of directly imaged protoplanets interacting with their natal environment is still lacking limiting our understanding of the planet formation mechanisms thanks to the revolutionary capabilities of the alma interferometer and the advent of upcoming infrared facilities such as jwst the time is ripe to finally detect planets in the act of formation and observe how their bulk and atmospheric properties is determined by the physics and chemistry of their birth surroundings unveil will bridge the gap between exoplanets and planet forming disks by directly observing and modelling the assembly of massive planets in disks at large orbital radii combining cuttingedge observational programs and ambitious modelling efforts i will a assess the onset of hydrodynamical instabilities facilitating the formation of planetary cores b search for protoplanets in the gas kinematics of disks and estimate their mass c image protoplanets in the midinfrared and determine how they formed d directly connect the chemistry of disks to the elemental abundances of protoplanet atmospheres this ambitious project builds upon a novel methodology that will be developed by my team to detect protoplanets in the kinematical structure of protoplanetary disks and on my leadership position in a pioneering alma large program to characterize the gas kinematics of planetforming disks in synergy with my groundbreaking jwst observations unveil will build a unique legacy for the whole community and provide observational constraints that are sorely needed to unveil the formation phases of cores and atmospheres of saturnjupiter mass exoplanets
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melding behavioural ecology and biomaterials research to track the evolution of mechanical superperformance of spider silk composites
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many organisms assemble biological materials into architectures and tools that add and extend biological functions with profound ecological effects and inspiring human technologies however there is no general concept of how evolutionary biomaterial innovation arises from both the physiological and the behavioural recombination of compounds supersilk aims to understand how mechanical superperformance evolves by disentangling the concerted effects of both physiological and behavioural factors on structurefunction relationships utilizing spiders and their silk products as a model system specifically supersilk will 1 determine if the diversification into different types of silk glands facilitated the evolvability of spider silk performance 2 test if the behavioural combination of different spider silks into compound threads provides a fast track for the evolution of thread performance and an extension of performance limits 3 test whether similar thread functions evolved via repeated or alternative pathways and 4 establish a roadmap for the targeted bioprospecting of silk compounds with specific properties being the first project that will jointly track the evolution of base materials and their behaviourally assembled compound products supersilk will address a timely question in evolutionary biology if and how the evolvability of physical traits can be modified by the evolution of novel behaviours and vice versa the outcome will be a precedent for the integrative study of animal products that will establish a new line of research evolutionary materials in addition by probing the structurefunction relationship of behaviourally assembled silk composites supersilk will reinvigorate efforts to develop supertough biofibres for industrial applications a field that has stagnated in recent years and enable the engineering of biofabrics with tailorable properties
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circular manufacturing 50 humancentred aiaided digital framework for closedloop photovoltaic pv products value chains
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the eu guidelines for circular production and supply chains require a strategic approach at every stage of the product lifecycle the shift towards circularity starts with circular design principles where the linear takemakedispose model is superseded by the one that prioritizes reusability reparability and recyclability circman50 combines advanced industry 40 technologies with humancentric design principles to assess and demonstrate how waste reduction and optimization of raw material can be feasible and profitable while significantly reducing the environmental impact of manufacturing processes circman50 delivers a humancentred aiaided framework for the photovoltaic pv manufacturing industry entailing i aidriven modelling and circularbydesign simulation techniques for product design ii ml algorithms for dynamic production process reconfiguration iii a cognitive digital twin environment supported by aas models for testing and verification of manufacturing processes for efficient resource utilisation waste management etc iii a circularity and life cycle assessment lca framework to help with comprehensive evaluation of the sustainability aspects of products and processes using datafeedback from aibased process optimisation forecasting models energy and emissions metrics etc iv the humanintheloop hitl recommendation engine to provide actionable and explainable recovery strategies for eol products v the digital productmaterial passport dpp enabled by distributed ledger technology enabling secure and trustworthy information sharing the learning resources developed in the project will equip the eu industrial workforce with digital circular and transversal skills circman50 will be tested in four 4 pv manufacturing industries providing different type of products eg perovskites pv bipv bapv opv
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theranostics ecosystem for personalised care
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thera4care represents a large unique consortium gathering wellestablished european academic radiotheranostic centres strong industry partners european and medical societies focusing on training and education a patient advocacy group spearheaded by an experienced project management group thera4care aims to establish a european network of radiotheranostics centres able to rapidly develop and implement radiotheranostics tools and solutions to drive precision health the overarching vision of thera4care is to revolutionise radiotheranostics procedures by establishing implementing and disseminating standardised scalable methods to produce and efficiently administer key radiotheranostics solutions thera4care focus is on developing diagnostic and therapeutic ligands tailored to key disease areas such as solid tumours aligning with the growing significance of multimodal radiotheranostics solutions dominated by radionuclidebased therapy and companion diagnostics thera4care project is scheduled for 5 years and consists of 9 work packages wp1 handles project management wp2 focuses on regulatory aspects wp3 plans preclinical studies wp4 provides supply chain wp5 develops clinical trials wp6 generates ai models wp7 focuses on dosimetry wp8 develops precision imaging components while wp9 focuses on education and dissemination thera4care will advocate for the progress of radiotheranostics with the goal of increasing medical knowledge and enhancing treatment efficacy for improved patient outcomes concurrently aims to coordinate scientific initiatives across european landscapes leveraging a comprehensive and multimodal approach to cancer therapy applicable to various cancer types lastly will work on the establishment of sustainable supply and production networks and the upscaling of production methodologies and supply chains across the public and private sectors to enhance the availability of radionuclides
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advanced ai based metasearch platform in photonics
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meetoptics is a deeptech startup founded by dr brbara buades and dr james douglas ceo ameetoptics is a deeptech startup founded by dr brbara buades and dr james douglas ceo and cto previously researchers from the institute of photonic sciences icfo and the university of oxford it is a disruptive solution unique in the global market being the first specialized search engine for realtime photonic components thanks to the development of artificial intelligence ai algorithms and neural networks it allows the global scalability of help and professional and precise technical guidance in this market the field of photonics is rapidly growing today there are more than 100000 optical components with which to manufacture lasers microscopes or spectrometers having approximately 30 technical aspects each crucial to the final performance professionals spend weeks and even months to select a single component exploring a small fraction of suppliers not knowing most of the time what they really need creating major industry disruptions meetoptics will provide a service through ai together with a realtime metasearch engine helping professionals match their technologies and helping suppliers and professionals refine their real needs meetoptics will shorten out photonics technology developments time and will improve companies throughput meetoptics is seeking women techeu funding to develop new advanced ai algorithms to scale up its database from 40000 to 200000 products validating its responsiveness to market demands from 100000 test users and saving time and resources to professionals and manufacturers it is a 9month project that is expected to start in 2022 the first day after the signature of grant agreement to subsequently go to market at the beginning of 2023in addition the women techeu mentoring and coaching support represents a great help to validate the business strategy identify new business multipliers and access new investors and partners internationally
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3d integrated photonic nanostructures with giant optical nonlinearity
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photonics has a major impact on technological innovations and can revolutionize the field of computing and data processing due to its high bandwidth speed and low power consumption this has already happened for data communication via fiberoptic connections while light processing in embedded systems is still performed by electronics via powerhungry opticalelectrical conversionthe future development of integrated photonics is then waiting for new integrable materials that can advance the functionality of photonic chips towards alloptical signal processing at very low light intensities while linear operations and parallel matrix multiplication can be efficiently performed by light nonlinear optical functions are notoriously difficult to implement because they require a suitable medium for efficient photonphoton interaction currently there is a lack of materials with large thirdorder nonlinearity high speed and easy processability and integration in 2d and 3d structures3dnanogiant aims to develop new nonlinear photonic materials that can be integrated into heterogeneous functional platforms or chiplets to this end i will exploit the giant optical nonlinearity of liquid crystals ten orders of magnitude larger than that of silicon for new formulations and lithographic strategies by which the liquid crystals will be confined in a printable nanoporous polymer network their 3d nanopatterning will enable the production of multidimensional hybrid nonlinear photonic devices from alloptical 2d logic gates and ultrafast nonlinear activation functions to selfoscillating 3d photonic crystals in parallel the propagation interaction and polymerization of solitons in a 3d1 space will lay the foundation for a new unsupervised bottomup 3d printing technology the goals of 3dnanogiant will redefine the stateoftheart in integrated nonlinear photonics with practical and versatile heterogeneous chip for fast and energyefficient optical processing
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effect of insulin and feedfast cycle on vaccine efficacy and safety
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though it has long been known that activated lymphoid cells upregulate insulin receptors the functional relevance of insulin signalling in immune cells has only recently begun to be explored this includes the recent finding that insulinstimulated activation in the pi3kaktmtor promotes immunometabolic reprogramming of t cells thereby promoting antigenspecific immunity similarly in liver cells insulin receptors have been shown to translocate to the nucleus where they participate in regulating genes involved in viral response and epitope presentation whats more various lines of evidence have implicated inulin signalling in the development of coagulopathies via its effect on the expression of cytokines complement and clotting factors whiles also affecting platelets and endothelium taken together these and other observations implicate an underappreciated immuneregulatory function of insulin yet even basic questions regarding insulin signalling in immune cells eg do t cells develop insulin resistance are currently unknown in the proposed study we will investigate the effect of insulin signalling in immune and nonimmune cells to evaluate the impact of insulin signalling on these immunerelated functions firstly we will leverage publicly available proteome and transcriptome data to reinterrogate these data sets from an immunological perspective complimenting these activities we will also conduct detailed cell culture experiments to evaluate the effect of a does and b duration of insulin on the release of clotting factors cytokines and complement as well as immune cell activation and polarization finally we will conduct a vaccine trial on a rodent model to evaluate the effect of insulin on vaccine efficacy beyond t1d and t2d these findings will also impact diabetic care in organ transplant gestational diabetes and the development of preeclampsia immunotherapies and intensive insulin therapy in criticalintensive care
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acorns revaluation for human consumption genomic selection and development of new functional foods
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the objective of acofood is to promote the consumption of acorn by human beings as it is a nutritious fruit with high production in the mediterranean region selecting the genotypes with the best functional characteristics for the consumer identifying markers related to healthy phenolic compounds and the absence of astringency and cytotoxicity and developing a healthy acornbased food dr mara vzquez is a researcher with a scientific background in the field of postharvest of fruits and biomedicine with great motivation to be able to combine these two disciplines contributing to the implementation of a healthy and sustainable diet
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characterizing the chromatin landscape of spinal muscular atrophy in response to aav9 mediated gene therapy
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spinal muscular atrophy sma is a fatal neurodegenerative disorder in children characterized by motor neuron loss and atrophy of muscle however sma affects many organ systems since the causal gene smn1 is expressed in all cells recently an aav9mediated gene therapy zolgensma was approved however challenges remain to be effective the systemically delivered aav9 smn1 needs to mimic the native regulation of the genomic smn1 in fact recent findings demonstrated that delivery of aavsmn1 under the control of the ubiquitous viral promoter cmv found in zolgensma eventually caused death of neurons in a mouse model of sma to date there has been no systematic categorization of how treatment with smn1 is regulated in different tissues through development furthermore little is understood about the chromatin changes that occur during sma how gene therapy impacts the longterm stability of patients epigenomes or how the aavdelivered dna is epigenetically controlled over time the goal of the proposed work is to understand how the epigenome reacts to gene therapy using sma as a model to do so i will i profile the epigenetic changes during sma disease progression in mice before and after gene therapy ii evaluate the role of various promoterenhancer structures in the vector on the epigenetic regulation of aavdelivered episomal dna and iii test if endogenous promoterenhancer combinations can be used to achieved a better tuning of the delivered gene the proposed project combines the expertise of dr piera smeriglio in sma models neuromuscular disorders and gene therapy with my expertise in epigenetic profiling gene regulation functional genomics and singlecell technologies aav gene therapies are poised to have a huge impact on rare diseases a key priority of the horizon europe programme making now a critical time to understand their effect on the epigenome and cell regulatory networks to increase the efficacy and safety of their use
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bridges in social networks harnessing dual identity to improve interethnic relations
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improving relations between ethnic minority and majority groups is one of the most pressing needs in modern societies this project will test a new theory that such relations can be improved by minority members who identify with both their ethnic group and the national majority group because these dual identifiers can create social bridges between communities however not all dual identifiers are recognized as such by others and misperception may undermine the bridging that dual identifiers can accomplish i propose that a dual identifiers relationships with members of both groups are signals of their dual belonging but that the degree to which these signals are picked up depends on peoples perception of the structure of their social networks b that perceiving dual identifiers improves intergroup attitudes and relationships and c that these effects occur most likely under specific situational and social psychological conditions thus this project will advance the interdisciplinary fields of intergroup relations and network science by moving away from the problematic assumptions of previous work that people are always fully aware of others dual identities and relationshipsi will develop and test a pioneering methodology to measure perceptions of peoples ethnicity and their relationships in social networks survey experiments and a two and threewave longitudinal school study will then be conducted to 1 detect how perceived relationships in social networks affect recognition of dual identifiers 2 uncover whether and how perceiving dual identifiers as social bridges improves interethnic relations and 3 discover factors that prevent or facilitate the effect of dual identifiers next to the theoretical innovation the focus on the consequences of perceived social networks will break new ground in social network analysis the findings will lead to new approaches for facilitating the development of positive interethnic relations
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pulmonary delivery of anticancer drug via an inhaled responsive nanogel with stealth ability and high targetability
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in this project i will investigate and develop nanogels incorporated into microgels containing encapsulated anticancer drugs these nanogels will be delivered via the respiratory system to the lung selectively swell and deliberate the therapeutic importance will be given to targeting moieties stealth moieties and biocompatibility the delivery of drugs for lung cancer is limited but is under investigation and on the rise of inquiry some of the challenges this type of technology faces are the efficient encapsulation of the bioactive compound inside a nanocarrier the targeted delivery the release of the drug the biocompatibility with the lung and the avoidance of the macrophages new methodologies for better delivery of therapeutics are of great importance at the national and international levels new materials and technologies are emerging every year the delivery of therapeutics for lung cancer is based mainly on intravenous therapies another way of introducing drugs into the area of importance in the lung could be pulmonary drug delivery as a good alternative pulmonary delivery is not a new technology but is strictly limited to specific conditionsillnesses the research capitalizes on the existing strengths of the experienced researcher er in polymer science and the expertise of the host institute in chemical biology in health drug research and biotechnology it will lead to several publications in highimpact factor journals transfer of knowledge and expertise that could be capitalized at an industrial level thus contributing to the research output distinctness and economy of europe overall the fellowship will allow the er to reintegrate into a longterm academic position after many years of fruitful research career in the academic sector in spain after this project the er will obtain new knowledge and training that will help him to establish a solid point for a better opportunity both in academy and in industry
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raw material provisioning and mobility patterns throughout the middletoupper palaeolithic transition in nw tuscany
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mobility investigates middle and early upper palaeolithic human organisation to exploit the landscape resources in nw tuscany huntergatherers hgs mobility patterns are understood to be in a spectrum between residential and logistical mobility hgs have shown to have sitefurniture personal and situational gear with different levels of manufacture and maintenance curation around 40 ka cal bp a technological and human species shift occurred in europe referred as the middleupper palaeolithic transition the northern tyrrhenian region is one of the few european areas that yielded a cluster of last neanderthal sites and the presence of early h sapiens it is a required passage between southern france and the rest of the italian peninsula and the further investigation of this area could shed light on the colonisation process of h sapiens and its relationship with the demise of h neanderthalensis the sites in nw tuscany are showing a different raw material provisioning in particular early h sapiens introduced the exotic scaglia marchigiana chert showing a longextended network that spans from nw italy until the central eastern apennines the action is an interdisciplinary endeavour to better understand differences of landuse patterns and reconstructing mobility patterns in the nw tuscany across the middleupper transition period through the technological analysis of the artefacts and the definition of raw material circulation
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cloudnative ultrasound imaging
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ultrasound us can revolutionize and democratize medical imaging if it offers 1 access for everyone and 2 excellent image quality always mri offers 2 but is expensive and will thus not likely be able to provide 1 lowcost us hardware will enable 1 in the future but is not expected to yield the needed breakthrough for 2 any solution that addresses both will have a huge impactthe biggest adversaries for us image quality stem from patient and userspecific factors i therefore strongly believe that achieving 2 requires closedloop goaldirected imaging through systems that actively pursue information gain insitu my erc stg project usact develops this new closedloop us paradigm with deep generative models governing beliefs about anatomy and function this however gives rise to a new dilemma how to embrace highperformant but complex algorithms to achieve 2 while at the same time lowering cost to achieve 1 our recent result shows that usact enables breaking the costcomplexity tradeoff through a new approach that is rooted in the closedloop proposition itselfi propose cloudsound a fully cloudnative us imaging paradigm unlocking access to virtually unlimited computational power memory and storage for raw us sensor data we will move all the computational complexity away from the local device to a remote server to achieve this with minimal latency and high frame rates cloudsound introduces a new holistic rate control strategy for the entire transmitreceive scheme based on algorithms developed in usact this will drive rate control of the full solution under a timevarying information bottleneck the network channelultimately cloudsound will disrupt ultrasound business models and unlock unprecedented image quality and ease of use making advanced medical imaging affordable and globally accessible
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deciphering cellular signalling to cure graftversushost disease gvhd and leukemia relapse
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acute graftversushost disease gvhd and leukemia relapse cause 75 of the mortality of patients having undergone allogeneic hematopoietic cell transplantation allohct a better understanding of signalling in immune cells tissue specific cell types and leukemia cells is key to develop novel therapies against gvhd and leukemia relapse the ambitious overall goal of allocure is to identify the pathogenic events that initiate gvhd 1 maintain therapyrefractory gvhd 2 and mediate immune escape causing leukemia relapse 3 to address these high riskhigh gain questions novel methods and developments across disciplines are required 1 i hypothesize that a loss of to date unexplored intestinal enteroendocrine cells promotes gvhd initiation to study these small cell subsets we will use reporter genes and novel imaging methods to systematically evaluate their fate and signalling during intestinal gvhd 2 signalling propagating refractory gvhd is not wellunderstood our phosphoproteomics data set from corticosteroid and ruxolitinibrefractory gvhd patients will instruct selective analysis of kinase activation in immune cells and enterocytes by using genetic creloxbased and pharmacological approaches 3 i have shown that leukemiaderived lactic acid inhibits glycolysis and mekerk signalling in t cells thereby impairing graftversusleukemia gvl effects here i will decipher which other leukemiaderived metabolites mediate pathogenic signalling in immune cells and test if oncogenic signalling in leukemia cells drives immunosuppressive metabolite production to enhance gvl we will inhibit pathogenic kinase activation in leukemia cells and myeloid suppressor cells using high riskhigh gain approaches in a combination of murine and human studies allocure aims to develop individualized therapeutic strategies to interfere with pathogenic signalling responsible for gvhd or leukemia relapse to reduce the mortality rate of patients undergoing allohct
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when was greenland green perspectives from basal ice and sediments from ice cores
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green2ice will investigate the deepest and oldest ice and basal sediments drilled from the greenland ice sheet gris ice cores have been drilled the last 55 years but the deepest ice containing basal materials has been preserved until now and still holds undeciphered paleoclimatic messages the breakthrough of green2ice is to develop and apply cutting edge dating methods on this unique sample collection and hence to reconstruct the age and the stability of the gris a hypothesis to test is if the present gris formed at the time of the mid pleistocene transition 12 08 million years ago one innovation of green2ice is to gain paleoinformation of the past size of the gris to constrain future tipping points this knowledge will reduce the uncertainty on estimates of future sea level rise green2ice will bring together four pis from three world leading institutions with complementary skills to lift this strongly interdisciplinary program we will drill a replicate core at grip to supplement the available material from five existing ice cores and ensure retrieval of sediments and rock material from beneath the gris summit we will develop improve and apply novel dating techniques cosmogenic and radiogenic nuclides oslirsl modeling of gas and isotope diffusion to place constraints on past waxing and waning of the gris stateoftheart methodologies on fossil remains organic matter in situ produced and consumed greenhouse gases and ancient biomolecules will provide insights on the types of ecosystems and environmental conditions that emerged during icefree conditions interpretation will include ice sheet modelling with data benchmarking to establish the climatic sensitivity of the gris earth system modelling and collaboration with the groups preparing the ipcc ar7 will bring the knowledge of the past into the future the rare and unique basal ice and material can only be used once this is the main high risk high gain component of green2ice
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selfcontracting vascular networks from fluid transport to autonomous locomotion of soft materials
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liquid flows in vascular networks are among the most effective ways to transport matter and information for life artificial vascular networks have mimicked this strategy without reproducing the same level of autonomy and adaptability from animals to fungi the most adaptable organisms control fluid transport with vessels that actively contract upon local sensing of stimuli this adaptative fluid transport enables functionalities in organisms such as autonomous locomotion toward objectives how are the orientation and rate of fluid flows controlled by selfcontractions how do these selfcontracting networks tailor autonomous functionalities so far we do not know studies on organisms are limited to observations and lack the systematical characterizations required to apply these observations to artificial materials selfflow hypothesizes that artificial vascular networks containing distributed sensors and actuators can decipher how selfcontractions enable adaptable fluid transport from there materials containing selfcontracting artificial vascular networks will enable systematical studies on the emergence of autonomous functionalities with this experimental asset reinforced by theoretical and numerical models my group and i will address the following questions q1 deliver how do selfcontractions transport fluids across networksq2 adapt how do selfcontractions autonomously adapt to the need of the network q3 behave how do selfcontractions enable living matter functionalitiesselfflow will combine active matter and mechanistic approaches to model fluid transport in selfcontracting vascular networks i will use these results to design active vascularized materials that use fluid transfer to autonomously locomote towards objectives and exchange information with their pairs this will open the way to autonomous robots that can change shape split or recombine like soft materials and develop functionalities beyond locomotion
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building a global criminal justice system at the domestic level
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joinedupjustice develops parameters for a coordinated system of global justice at the domestic level while the projects focus is on international criminal law icl international refugee law irl is the starting point it is the metaphorical canary in the coal mine that flags up questions at the heart of iclmany of the domestic prosecutions of international crimes crimes against humanity war crimes genocide are asylum related this comes with problems first article 1fa of the refugee convention exclusion clause stipulates that those who are suspected of having committed international crimes are undeserving of protection and should be prosecuted there is no uniform understanding of undeserving at the same time icl lacks an overarching policy of who is deserving of prosecution many excluded asylum claimants remain unprosecuted and exist in a legal limbo second asylum related prosecutions have a distorting effect it comes with a focus on lowlevel and low cost defendants from weak countries third it hampers developing a longterm approach to icl enforcement the project consists of 5 work packages and 9 subprojects i through empirical research in 8 focus countries and comprehensive caseanalysis it maps who is deserving of prosecution whilst scrutinizing the enemy of mankind narrative no safe haven and end to impunity goals ii it clarifies the scope of undeserving and draws the line between criminal complicity and noncriminal association addressing the iclirl mismatch that leaves many in limbo iii it proposes a system of jurisdiction designation based on subsidiarity and burdensharing plus a settlement proposal premised on a right to start again iv allows for policy integration v and synthesises findings into an account of coordinated global criminal justice the projects ambition scope and methodology will lead to a step change in international criminal justice where the future is domestic
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advansic advances in costeffective hv sic power devices for europes medium voltage grids
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for a larger deployment of clean and sustainable energies more efficient and competitive converter solutions are necessary in this framework wide bandgap wbg technology provides benefits compared to conventional silicon technology even those benefits are well known eg efficiency andor sufficient reduction on converter footprint right now sic are far too expensive and its cost has a negative impact on overall system costin the view of this situation the objective of advansic is to produce test and validate costeffective hv sic mosfet semiconductors in various mvdc grid applications a solidstate circuit breaker for dc converter stations a fullscale wind converter and a fullscale solar inverterthe aim is to minimize hv sic device cost by advanced design structures and process optimizations and afterwards assure an immune and reliable environment to handle sic fast transients as well as optimize passives and cooling system to provide cost reduction not only at device level but also at system levelthe main goal of advansic is to provide industrial leadership in key and emerging technologies to smes startups and industry from europe to europe specifically in a technology that will be key to provide clean and affordable energy
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restoring emotional stability through neurofeedback and ai for transformative empowerment
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emotion regulation er is the key to mental wellbeing disruptions in the brain er circuitry is a transdiagnostic mechanism underpinning a wide spectrum of affective disorders that contribute to the mental health economic burden of 600 billion euros annually in europe this project focuses on major depressive disorder mdd predicted to become the leading cause of global disability by 2030 conventional treatment is ineffective for approximately 4060 of patients underscoring the crucial need for innovative therapeutic approaches in this context neurofeedback nf on er with functional magnetic resonance imaging has emerged as a promising tool for the treatment of mdd in research settings nf is a training that enables people to regulate their brain activity by providing realtime feedback on specific brain patterns in this case on brain areas involved in er to bridge the gap between clinical practice and academic research resonate will validate the clinical effectiveness of an electroencephalography eeg nf protocol targeting er circuitry going beyond the current state of the art we will conduct a placebocontrolled study involving 72 mdd patients stratified into nf shamnfplacebo and control groups a collaboration with the national kaohsiung medical university taiwan will add a second nf dataset of 60 subjects the second goal entails advancing the validation of novel deep learning algorithms for eeg timeseries data analysis and testing generalization to different cultural datasets deploying them to predict the success of nfa key challenge within the field by incorporating a startup into the project we will explore the industrial potential of this research as such through resonate and its objectives psychiatrists psychologists ai experts and industrial innovators will come together to advance mental health interventions and explore the boundaries of stateoftheart ai methods unlocking new research avenues and market opportunities
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innovative pilot lines for sustainable graphenebased flexible and structural energy harvesting and storage devices
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graphergia aims is to develop a new sciencebased holistic approach implementing new advances to achieve onestep laserassisted synthesis processing functionalization and simultaneous integration of graphenebased materials and graphene nanohybrids directly into relevant energy harvestingstorage devices this will lead to a scalable costeffective and climateneutral production of i etextiles with the specific functions of wearable power supplying and selfpowered structural sensors and ii next generation electrodes for liion batteries based on current trl 34 activities the consortium explores novel ideas for 2d materials engineering and integration at trl 5 or higher establishing versatile pilotscalebased approaches for these two types of applications configurations of tengbased etextiles will be prepared to fabricate flexible architectures designed to sustainably convert energy from the environment to electricity laserscribed solidstate microflexible supercapacitors will be coupled to tengs via innovative power management circuits acting as energy reservoirs to provide ondemand batteryless charging to wearable devices and sensors allinone selfcharging power textiles with integrated electronic systems will provide a humanbodycentric technology and interface of the user to the iot by wireless transmission of sensors signals in parallel graphergia defines a credible dry electrode approach to fabricate next generation electrodes for liion batteries aspiring to reach the technicaleconomic targets of the 2030 european setplan the proposed methodology will be implemented by blending recently devised iprprotected technologies of consortium partners to achieve these targets a combined 2d materials and processoriented approaches will be adopted based on lowcost raw materials and inherently scalable fabrication approaches to ensure a costeffective and climateneutral production of energy harvesting and storage devices
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beauty and inequality physical appearance symbolic boundaries and social disadvantage in five global cities
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how does physical beauty contribute to social inequality this innovative multidisciplinary comparative project aims to build a comprehensive new theory that explains how evaluations of physical appearance work and how they reproduce durable inequalities in todays mediasaturated servicebased consumer societies it hypothesizes that 1 in contemporary societies beauty is an important form of capital for all genders over the lifecourse 2 beauty as a form of capital intersects with existing axes of inequality like gender race class age sexuality nationality 3 the growing importance of appearance spawns new forms of inequality the project investigates these hypotheses in 5 global cities on 4 continents accra brussels buenos aires hong kong and tehran an international team will employ a mixedmethod design to study how aesthetic evaluations of appearance are shaped and identify the mechanisms by which these evaluations shape social disadvantage this high riskhigh gain project breaks new ground in our understanding of human beauty and its consequences it brings together scattered insights from many disciplines in a new theoretical model and tests and refines this model with explorative qsort survey ethnography and hypothesistesting lab field experiments methods it addresses central societal and scientific challenges by foregrounding the importance of a soft cultural factor in shaping social divides and the growing role of media in shaping social disadvantage and exclusion all subprojects study two domains where mediatization has made appearance more salient dating and job search the project structure is designed to tackle its high risks its global scope multidisciplinarity and its ambition to simultaneously develop novel methods and a new theory the project is led by a cultural sociologist with a strong track record in interdisciplinary and comparative research and in analyzing the serious consequences of frivolous topics
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catalytic lightinduced deracemization
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molecules are chiral if they exist in two forms called enantiomers which behave like image and mirror image in many applications eg in medicine nutrition and crop protection chiral molecules are required as a single enantiomer enantiomerically pure compound but not as a mixture racemate the market for enantiomerically pure compounds exceeds 100 billion annually and continues to grow rapidly despite significant recent advances in asymmetric catalysis many chiral compounds are for cost reasons prepared as racemates and separated thereafter if only one enantiomer is required the other enantiomer remains as waste the aim of the calide project is to provide for the first time a comprehensive set of methods for the quantitative conversion of racemates into single enantiomers employing exclusively light and a photocatalyst the process includes the lightinduced formation of shortlived achiral intermediates which decay to the starting materials on a thermal reaction channel by employing two intrinsically different channels for formation and decay the transformation overcomes issues of microscopic reversibility which render related thermal deracemization reactions impossible the photocatalyst interacts with the racemic substrates and enables the destruction and reformation of the stereogenic element a first objective work package i is to identify suitable binding motifs to achieve the required proximity in the energy transfer step for compounds displaying an axis or plane of chirality the second objective work package ii aims at a deracemization of compounds with a stereogenic carbon center via a reversible cleavage of carboncarbon or carbonheteroatom bonds the bond cleavage can be initiated by energy or electron transfer the third objective work package iii tackles substrates with a carbonhydrogen bond at the stereogenic carbon atom bond fission by hydrogen abstraction from the catalyst is proposed as the key feature of this method
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cogstim online computational modulation of visual perception
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computational models of vision often address problems that have a single and definite endpoint such as visual recognition an example of this might be to find a ripe banana in a complex scene however not all computation is of this form visual information is processed continuously in sensory areas and the nervous system has the capacity to alter or halt an ongoing behavioral response to changes in incoming information we can therefore react flexibly to updated sensory input or changed requirements for motor output on the other hand these same neuronal mechanisms must also support perceptual stability so that noisy signals do not cause loss of a crucial goalin project cogstim i will investigate the functional neuronal networks that support the balance between perceptual flexibility and stability within primate visual areas i will use a highly innovative approach combining dense electrophysiological recording with online realtime decoding of neuronal correlates of the subjects perceptual choice based on adaptive machinelearning algorithms in order to control visual perception effectively and predictably closedloop electrical stimulation will be applied under dynamically adjusted feedback to identified neuronal circuits that causally modulate associated percepts crucially this novel approach using joint decoding and stimulation in real time will allow me to target dynamically visual percepts representing a significant advance in our understanding of ongoing continuous computations of the primate brain such developments offer promising bases for the future development of rehabilitative therapeutical protocols as well as innovative brain machine interfaces suitable for realworld use
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cold war europe beyond borders a transnational history of crossborder practices in the alpsadriatic area from world war ii to the present
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this project aims to rethink the history of cold war europe by examining the development of transnational crossborder cooperation from the end of world war ii to the present overcoming traditional narratives of a clearcut european separation symbolised by the berlin wall a decentralised analysis of recent european history will show us that the question of a divided continent should be reframed the final objective is to challenge a dichotomous vision of two separate europes east and west from a new border perspective to this end a highly qualified team of senior and junior scholars under my guidance will focus on the alpsadriatic region a historical area that is now shared by austria italy slovenia and croatia this case involves a relatively narrow geographical area but an unusually broad typological range of subjects during the cold war it was divided among socialist but nonaligned yugoslavia capitalist but neutral austria and nato and eec member italy its development from the southern end of the iron curtain in 1946 to the most open border during the cold war and a precursor to presentday schengen europe represents a paradigmatic case to study an alternative attitude towards borders frontiers and boundaries drawing on cold war and borderland studies social history and the history of european integration which up till now have not found common ground our innovative conceptual elaboration will demonstrate the interplay between topdown politics and bottomup initiatives thus offering a new and more nuanced history of cold war europe from the border perspective reconsidering the european past from this transnational angle both in terms of geographic and methodological perspectives will allow us to rediscover the human face of european integration and will offer us a new platform for contemporary discussions on sovereignty territoriality and belonging and on the future role of borders in europe and in the world
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spatial perception and embodied autonomy research
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the popular unmanned aerial robot designs are inspired by manned aerial vehicles from the early 20th century since the 2000s quadrotor drones have dominated the small aerial robots domain due to their structural simplicity and agility is further development bound to incremental improvements in their design alongside progress in the autonomy stack we argue that future research cannot focus on incremental or separate steps in drone design and autonomy alone despite the outstanding progress in various domains from control to perception and beyond conventional multirotor systems are subject to multiple limitations that constrain their utilization envelope furthermore todays designers often need to tailor their robots to a specific task in a particular application domain which however is particularly timeconsuming unlike the current practice we propose a novel approach to change the paradigm in the design process we depart from the compartmentalized approach of humanengineered designs and investigate the holistic cosynthesis of taskspecific flying robot embodiment and autonomy through a synergistic combination of evolutionary algorithms and deep learning for navigation we aim to show the benefits of breeding unconventional bodies and brains bodies rely on an evolutionary combination of rotary wing components and soft and rigid elements whereas brains exploit the latest progress in deep neural networks this fundamental change in the design procedure offers a unique pathway towards more capable more resilient intrinsically safe flying robots upon its success spear will drive the robotics community forward and towards automatically designed and taskoptimized flying machines with superior performance
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phygital solutions for the cultural and creative industries
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amplify is a consortium of artists technologists and researchers from 8 european countries dedicated to facilitating the digital transition in the cultural and creative industries ccis it rests on three ideas a music is humanitys universal and transversal nonverbal language enriching many cci sectors b physicaldigital phygital experiences enrich the cci offer with new opportunities c impactful social value stems from cocreation by both professionals and nonprofessionals amplify will develop test and pilot two innovative suites of digital technologies empowered by ai and xr for ccis amplify portable is a costeffective easytouse tool to facilitate people in different places to play learn and perform together especially at community level amplify immersive enables producers to promote live performance experiences to distributed and remote audiences both tools will be opensource and although focused on music transferable across the spectrum of cci sectors amplifys technology will be developed and tested with a diverse range of creative partners and situations in four smallscale pilot trials 1 renewing tradition remote learning and performance in gaelic folk culture uk 2 music with babies digitallyenabled music cocreation with families pt 3 stage diving augmented reality concerts connecting artists and audiences it 4 revealing opera immersive experiences of cocreation with communities es the project will involve other cci sectors from the start explore their needs desires and fears about the digital transition and generate added value as early as feasible amplify rests on a humancentric approach that balances the tools and their use so that the whole project delivers not only innovative technologies new ways of working and enhanced audience experiences but also sustainable economic models consistent with the beliefs values and practices of the creators and audiences for wider societal benefit
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e3udres2 entrenovators cooperating for excellence and impact in research and innovation
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in line with its vision mission core values culture and principles the eudres entrenovators project aims to cocreate a more specific joint research and innovation strategy and a common agenda to accelerate the transformation into a european multiinstitutional research and innovation hub for smart and sustainable regions eudres entrenovators includes interacts and collaborates with a diverse variety of smart and ambitious people academic institutions regional authorities companies european ri networks and regional innovation ecosystems eudres entrenovators is committed to scientific excellence and research integrity within its crossdisciplinary and crosssectoral key ri networks and promotes future ri competences skills resources methods training services and management for collaborative research and open innovation for smart and sustainable regions
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research infrastructures in a changing global environmental and societal context
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the aim of this project is to organise a conference on research infrastructures during the belgian presidency of the council of the european union in the first half of 2024 the conference will take place on 46 june 2024 at the royal library of belgium kbr it will be a 15 day event combined with a half day dedicated to the visit of research infrastructures the conference will focus on 3 main issues 1 ris as key players of strategic autonomy in a changing global context 2 the societal and environmental impact of ris and 3 the broad ecosystems of research infrastructures
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controlled synthesis of panchromatic electrochromic polytriarylamines
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the goal of cosypantera is to develop a synthetic route giving access to easytotailor electrochromic panchromatic piconjugated polymers that will undergo a clear transparent to color change with high durability strong color contrast and fast switching time to achieve it i envisage preparing structurallycontrolled polymers with multiple redox states polyelectrochromes that can be obtained by superimposing individual visiblelightabsorbing electrochromes this is engineered by installing electrochromic moieties eg carbazoles for green and phenothiazines for red as pendant groups on a blue electrochromic triarylaminebased polymer backbone known to form stable radical cations upon oxidation to obtain polytriarylamines with desired structural characteristics i will develop a novel catalysttransfer polymerization ctp method based on the buchwaldhartwig cn bondforming reaction abtype monomers bearing electrochromic substituents will be prepared and depending on the ctp protocol alternate and block copolymers will be designed this approach will provide welldefined and reproducible triarylaminebased polymers with tailored characteristics average molecular weights narrow molecular weight distributions endgroup fidelity composition and color without the use of toxic reagents integration of these polymers into electrochromic prototypes will provide feedback to finetune the polymer structure characteristics and electrochromism as proofofconcept i target the synthesis of a panchromatic aimedatblack triarylaminebased polymer the most demanded color in electrochromic applications this fellowship will allow me to continue my training in the field of organic chemistry expanding my expertise into functional materials and properties assessment with the goal to shape me from a prime researcher into a fullfledged scientist kicking off his independent career
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healthy municipal soils
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the eu mission a soil deal for europe soil mission aims to lead the transition to healthy soils via sustainable soil management this requires knowledge and awareness of the importance and value of soil health and its challenges and drivers across europe engaging and activating municipalities and regions across europe to protect and restore soil health is vital for a successful soil mission deployment the creation of spaces for dialogue with quadruple helix stakeholders including marginalized andor vulnerable strata of the population on soil health and land management issues may contribute to develop a shared understanding of the challenges and help cocreate solutions for the protection and restoration of soil within this context humus main aim is to facilitate the deployment of the soil mission across regions and municipalities through i the creation and experimentation of spaces for social dialogue on soil health among public and private actors in europe ii the promotion of a shared understanding and coassessment exercises of soil challenges biophysical and socioeconomic dimensions and iii the enhancement of knowledge sharing among municipalities and regions including on the needed transformations in current s4 sustainable smart specialisation strategies and the use of available eu funds to support the transitionhumus will support the involvement of stakeholders and citizens in the decisionmaking processes via case studies educational and capacity building activities as well as exchanges of best practices at regional and local levels humus will further contribute to raising the problem awareness of regional and local governments businesses and society at large through the use of the biodistricts multistakeholder methodology whereby wellinformed local production and consumption patterns are planned in a coordinated way by all actors of the supply chain humus will particularly encourage social innovation and the implementation of a transdisciplinary approach at each partner territory regional and local governments will be closely associated from an early stage in order to develop effective participatory processes and stimulate extensive dialogues on soil health regions and municipalities will be empowered to reflect deliberate and propose appropriate and realistic solutions together with citizens and stakeholders humus will create and manage collaboration opportunities and spaces of dialogue between citizens and other stakeholders eg farmers and other land users and public authorities to mutually benefit from discussions in humus as well as from the latest developments and findings from european projects and networks humus will also support public authorities at local regional level associations of land managers eg farmer associations civil society organisations and research institutions throughout europe to establish constructive dialogues on soil health through the launch of an euwide open call aiming to provide funding to at least 20 exemplary pilot projects hence humus will also contribute to increasing knowledge sharing among municipalities and regions matching needs with already available methods tools and approaches for social engagement and knowledge valorisation the consortium is composed of universities and research centres with experience in participatory approaches and multistakeholder associations with large coverage of eu regional and municipal governance levels
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sensing and quantum engineering with magnetically functionalized ultracoherent mechanical resonators
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strained nanomechanical resonators have recordhigh quality factors at room temperature and stateoftheart thermallimited force sensitivities however they are typically made of dielectric materials that do not interact strongly with neither sensing targets nor other quantum systems i propose to functionalize ultracoherent mechanical resonators with a nanomagnet to unleash their potential both for nanoscale magnetic sensing and the creation of hybrid quantum systems the force sensitivity of the best strained nanomechanical resonators allows sensing of single proton spins when functionalized with a nanomagnet providing new ways to characterize quantum devices and to investigate the threedimensional structure of complex molecules such as proteins direct coupling of mechanical resonators and a single twolevel system is a challenging but attractive route to synthesis of arbitrary quantum motional states in mechanical resonators the low frequency of strained nanomechanical resonators has made this type of interaction elusive but recent progress makes it conceivable to coherently couple a single atom and mechanical motion by direct magnetic coupling i will leverage optical tweezer technology to directly couple the internal quantum states of a single atom to the motion of an ultracoherent mechanical resonator and exploit this interaction to generate quantum states of motionby combining integrated photonics with ultracoherent nanomechanical resonators sequence will develop unprecedently sensitive onchip force sensors that can be used for characterization of biomolecules and quantum devices the hybrid atommechanical system will realize a new interaction between single quantum systems and mechanical resonators which can be used in tests of fundamental physics quantum sensing and quantum information processing
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precision qcd lhc using energy correlators
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this project will have a major impact on the lhc extraction of the top quark mass which is one of the most important measurements to be performed in the coming years currently the top mass measurement suffers from theoretical imprecision including an overreliance on monte carlo mc simulations and an inadequate treatment of nonperturbative hadronization physics with no systematic prospects for improvement to address these challenges this project adopts cuttingedge approaches using the powerful theoretical tools of effective field theories of qcd and novel jet substructure techniques the proposed action will pave the way for a subgev precise measurement in a welldefined fieldtheoretic mass scheme eliminating longstanding uncertainties in the current methodology it will also simultaneously tackle the challenges of systematically accounting for hadronization effects which have also impacted jet substructure determinations of the strong coupling constant the project leverages the experienced researchers er unique expertise in this area and established collaborations with lhc experimentalists its cornerstone is the use of energyenergy correlators eecs which enable precision measurements in the complex environment of the lhc by efficiently removing various sources of contamination in the jets while providing a theoretical control superior to conventional jet substructure observables capitalizing on the ers recent proposal to exploit eecs on boosted top quarks as a top masssensitive probe we will compute stateoftheart theoretical predictions for this top masssensitive observable with nexttonexttoleading logarithmic nnll accuracy well beyond the reach of current mc simulations with the primary goal of enabling a direct comparison of theoretical prediction we will develop a systematic modelindependent fieldtheoretic framework for describing hadronization corrections in complex modern jet substructure observables
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mathematical challenges of higherorder interactions in collective dynamics and applications
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the mathematical analysis of collective dynamics has experienced a prominent growth in the last years leading to new frontiers with cuttingedge fields in physics biology and social sciences eg complex networks active matter or crowd dynamics the deep breakthrough is that unveiling selforganization in a large group of agents can be tackled using strong mathematical methods from nonlinear and nonlocal pdes like harmonic analysis energy methods optimal transport and fluid mechanics hicody aims to go beyond the classical restrictive case of pairwise interactions indeed recent advances in neural networks suggest that higherorder interactions are often needed to properly shape collective dynamics classical techniques break down in this setting thus requiring innovative methods this proposal is divided into three blocks the first one aims to derive the rigorous kinetic and fluidtype pdes of statistical mechanics from the underlying microscopic description to represent higherorder interactions at larger scales besides the formation of patterns from multiple interactions will be analyzed in several examples of velocity alignment and synchronization dynamics the other blocks integrate an interdisciplinary approach which combines analytical and computational tools to face the demanding technical level in two innovative applications neuroscience and developmental biology first novel activity patterns will be explored in large ensembles of neurons with multiple interactions second a new pde for filopodiamediated morphogenesis will be rigorously derived supported by empirical evidence contrarily to turings theory based on free diffusion as an evidence of the researcher capabilities he has pioneered techniques to derive hydrodynamic and mean field limits in flocking and synchronization models with pairwise singular interactions the project will be developed alongside his supervisor who is expert in nonlinear pdes and mathematical biology
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rashba effectinduced nonvolatile ferroelectric control of spinorbit coupling in twodimensional materials
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the surge of electronic devices in our everyday lives poses severe challenges to the sustainability of our societies spintronics stands at the forefront of solutions considered today by leading industrial actors to drastically improve information and communications systems scalability and power efficiency in this field most of the efforts focus on information storage based on ferromagnets fm readout via spincharge interconversion sci phenomena ie the conversion of a spin polarisation into a detectable electrical signal or viceversa however improvements in sci efficiency are still necessary and solutions for the electrical writing of fm still need to be more efficient and reliable ferroelectrics fe which naturally break inversion symmetry may allow an efficient sci when interfaced with other materials since fe also carry information their electric polarisation switchable at ultralow power they are ideal candidates to replace fm as the new core elements of spintronics so far only a few reports demonstrated the fe control of sci at oxide interfaces or in bulk semiconductors due to their richness and 2d nature van der waals vdw materials and notably graphene play an increasingly important role in spintronics research and vdw fe could be a game changer for the field although they are still underinvestigated revolt aims to study these novel fe and to achieve the nonvolatile electric control of sci in graphene proximitized with fe structural electrical and magnetotransport characterisations will be performed on atomically sharp fegraphene stacks patterned with advanced nanolithography techniques for which the host institution is expert based on these efforts revolt will shed new light on fundamental physics phenomena and evaluate the potential for a paradigm change in spintronics applications while providing highquality interdisciplinary research and transversal skills to a young researcher for the development of his career
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how plant cells set the tempo of rhythmic shoot construction
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time is central to the development of the body plan of multicellular organisms one prominent developmental timing mechanism is the rhythmic iterative addition of tissues and organs while the tempo of rhythmic construction is often set by developmental clocks plants use a unique mechanism in the shoot whereby rhythmic organogenesis emerges from dynamic changes in the distribution of the hormone auxin high auxin levels trigger organogenesis but contrary to a longstanding theory the period of shoot organ production or plastochron cannot simply be encoded in periodic auxin oscillations due to noise in these oscillations revealing how the tempo of shoot construction is established thus remains a critical knowledge gap in plant biologyin tempo we hypothesize that cells record and use the history of their auxin exposure in order to robustly set the timing of organogenesis and the plastochron at the tissue scale despite noisy auxin temporal information this fundamental change in the way we understand the relationship between auxin and the plastochron stems from preliminary data from my team suggesting histone acetylation as an epigenetictracking mechanism which allows auxin temporal information to be recorded and utilized for transcriptional controluncovering how auxin temporal information establishes the tempo of shoot construction requires multiscale multidisciplinary approaches we will combine cuttingedge liveimaging synthetic biology and computational modeling with innovative optogenetics and singlecell genomics to both ascertain and perturb auxin temporal information and histone acetylation at high resolution while assessing the effect on cellular transcriptional states and the timing of organ production beyond testing whether epigenetic tracking of auxin temporal information sets a robust plastochron across scales we will reengineer the plastochron to demonstrate that the tempo of shoot construction can be predictively manipulated
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the equitable inclusive and humancentered xr project
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extended reality xr technologies have within a few years moved from labbased research to a commonplace consumer item indeed the benefits of and the possibilities that xr technologies offer to promote and enhance are prolific as with other emerging technologies however the use and eventual ubiquity of xr technologies bring with them potential risks that have not existed before of particular importance are new ethical and associated safety privacy security challenges and interoperability issues that needs to be considered now developing the foundations to ensure that europe is sufficiently equipped to leverage these opportunities through skillful navigation of new challenges is the rationale for xr4human the main objective of the project is to cocreate living guidance on ethical and related policy regulatory governance and interoperability issues of xr technologies within a european community of practice this main objective will be operationalized through the following specific objectives explore i ethical issues and ii related regulatory and governance issues guide companies and regulators through i interoperability guidance document ii a european code of conduct for equitable inclusive and humancentered xr technologies iii recording and demonstrating the practical application of the xr code of conductequip companies and regulators with an online repository of test cases to allow developers to demonstrate evidence of adherence to best practicesequip and guide users through a rating system and educational materialsengage companies and other stakeholders i to enhance the uptake of the xr code of conduct the guidance for interoperability and the empowerment of endusers and ii to establish a permanent digital european forum to facilitate stakeholder dialogue on issues of ethics and interoperability
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the genomic adaptations to cope with unpredictable climates over the course of life
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increasing climatic fluctuations mean that animals need to evolve increased heat resilience whilst simultaneously coping with cold periods throughout their lives large animals are particularly susceptible to temperature fluctuations as their large size when mature exposes them to heat stress and their small size when juvenile exposes them to cold stress i will test two hypotheses that are central to understanding how large species evolve to cope with temperature fluctuations 1 genomic adaptations that increase heat resilience compromise cold resilience 2 genes that increase thermal resilience during early life have opposing effects on thermal resilience later in life testing these hypotheses requires identifying the genomic basis of thermal resilience this has remained elusive in large animals because of difficulties in 1 rearing high numbers of large animals 2 exposing them to natural temperature fluctuations and 3 obtaining measurements of fitness related traits such as growth of juveniles and reproduction of adults i will solve these issues by studying the largest bird on earth the ostrich monitored in large numbers under natural temperature conditions this will allow me to take an interdisciplinary approach combining body temperature measurements and cuttingedge genotyping of 2000 juveniles and adults a close partnership with a south african research station will enable me to utilise data of growth and reproduction of 11700 juveniles and 1800 adults exposed to the natural climate over 25 years to test the importance of identified genes for local climatic adaptation i will genotype natural populations of ostriches across climatic gradients my work will resolve how genes conferring resilience to heat influence the ability to cope with cold and if the same genes are important across different lifestages this will shape our understanding of thermal evolution in endothermic animals at a critical time
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new superconducting quantumelectric device concept utilizing increased anharmonicity simple structure and insensitivity to charge and flux noise
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quantum technology is an exciting field where new scientific discoveries have great potential to be used in practical applications such as in quantum computing although quantum supremacy has been recently demonstrated in fully superconducting qubits there is a major challenge in promoting these manyqubit processors feasible for technological applications and advanced science experiments fidelity of all qubit operations well above 999 in a powerefficient control and readout architecture is requiredthis project conceptq aims to demonstrate a new superconductingqubit concept that has a surprisingly simple structure consisting only of standard materials and a single josephson junction while providing insensitivity to charge and flux noise and most importantly large anharmonicity we combine these properties with a new multimode enhancement idea to demonstrate recordbreaking fidelities in quantumlogic gates in initialization and in readout importantly we introduce cryogenic active components to implement all these three basic operations at millikelvin temperatures thus paving the way for a powerefficient integrated quantumclassical control system finally we use the best new methods and designs for multiqubit processors and demonstrate a new quantum algorithm at high fidelity with these breakthroughs we aim to supersede the transmon as the standard highfidelity superconducting qubit thus boosting quantumtechnology research and methodology not only in computing but also in sensing and simulation this potentially opens horizons for novel scientific discoveries in classical cryoelectronics quantum calorimetry open quantum systems and quantum thermodynamics conceptq is a science project but thanks to ongoing collaborations with the quantum industry it holds great potential for advancement of global wellbeing eg through envisioned longterm applications in cyber security quantum chemistry and artificial intelligence
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science in the city
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this innovative and highly interactive festival seeks to create bridges between science research technology and the arts it aims to attract maltese and europeans from all walks of life engaging visitors with activities performances workshops experiments installations exhibitions talks comedy sports and so on the science in the city malat festival shines a spotlight on researchers who work with the sitc team artists and members of the community to create fun events for our audiences to better understand and enjoy the research besides showing adults youths and children that steam is fun exciting and offers great career opportunities for all interests the festival emphasises how vital creatvity is to nurturing critical thinking skills we aim to highlight the importance of looking to science and research to improve the world we live in by encouraging changemakers to look to knowledge and info about hte latest scientific developments to support their drive for change
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trustworthy ai for ccam
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considering artificial intelligence ai capabilities and potential risks and taking into account its limitations ai4ccam will develop an open environment for integrating trustworthybydesign ai models of vulnerable road user behaviour anticipation in urban traffic conditions and accounting for improved road safety and user acceptance leveraging the trustworthy ai guidelines for general intelligent software systems and the ethics recommendations for connected automated vehicles ai4ccam will support aibased scenarios management in which pedestriancyclist behaviour anticipation models will integrate visual gaze estimation and where explainable ego car trajectory prediction models are simulated with ethical dilemmas and multiplied with generative adversarial networks and metamorphic testing techniques the ai4ccam open environment will include an interoperable digital framework for managing and generating aibased urbantraffic scenarios in which trustworthybydesign ai models can be tested and an online participatory space to foster acceptance of ai in automated driving determine ai risks and identify biases in datasets and cyberthreats simulation scenarios of road users interacting with automated vehicles will be developed and evaluated in three complementary use cases covering the whole senseplanact paradigm and user acceptance as such the project will advance knowledge in building trustworthybydesign aibased solutions for ccam applications
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artisanal productions in early iron age protourban centres of north adriatic region
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between the end of the 9th and the beginning of the 7th centuries bc the veneto and friuli venezia giulia regions northeastern italy as well as slovenia were involved in a significant process referred in literature as protourbanization during this period a revolutionary territorial political and social rearrangement is attested achieved through the strong competence of communities and their ruling elites in managing resources and establishing permanent intercultural and extraterritorial networks atelier is the first largescale noborders and systematic research project focus on the analysis and the comprehension of the role importance and structure of the artisanal productive framework within the early iron age protourban centers of the north adriatic region and its impact on the subsequent sociocultural and economic landscape this research aims to provide new insights into the crucial phase of establishment and consolidation of protourban centers by investigating the specific characteristics associated with artisanal production identifying the principal models of production through the analysis of craft specializations and resource management systems by examining the patterns of distribution and circulation of goods within and beyond the communities involved in this phenomenon atelier project will identify networks and exchange trajectories that facilitated trade interactions and horizontal mobility in this area strongly connected both in geographical and cultural perspectives the interdisciplinary approach adopted by atelier integrating traditional archaeological methodologies with archaeometry and spatiallandscape analysis will be fundamental for reconstructing the historical territorial and economicproductive scenario of the early iron age
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understanding the impact of environmental pollution on the adaptive immune system
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there is growing evidence that currently used toxicological assessments of chemicals fail to fully capture their actual biological activity while chemicals are routinely tested for acute toxic effects often at high concentrations potential functionmodulating effects at low concentrations are often underexplored the inclusion of uptodate highresolution methods in the toxicological screening praxis would allow instead to fully capture the complex bioactivity profile of these compounds which depends on numerous aspects including bioavailability route of exposure and individual susceptibility while the last 100 years have seen an enormous number of chemicals introduced into our daily life of which a large number are wellknown to persist in the environment a sufficient understanding of their bioactivity potential is lacking also based on growing evidence it is not farfetched to hypothesize that some of these industrial chemicals could be partly responsible for the constant increase of noncommunicable diseases including autoimmune diseases chronic inflammatory diseases but also cancer or neurodegenerative diseases perfluoroalkyl and polyfluoroalkyl substances pfas are a class of xenobiotics with proven strong toxicity at highlevel exposure while little is known about their bioactivity at concentrations commonly detected in human samples considering their high stability and ubiquitous occurrence in the environment and human body exposure to pfas has reached a pandemic scale i postulate that it is of outmost importance to finally dissect the potential of these compounds to molecularly interfere with organ functionalities at the singlecell level using stateoftheart highresolution omics technologies supported by an interdisciplinary training in pharmacology systems immunology omics animal and cellular models and bioinformatics i represent a prime candidate to successfully develop this project and clarify the bioactivity of pfas
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development of an innovative gpm for the zephyr microlauncher
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latitude a french launcher company ambitions to become a world leading endtoend space access provider by developing and operating a dedicated microlauncher called zephyr zephyr is a launch vehicle which will be able to place small satellites of up to 200 kg in a low earth orbit this launch solution is expected to be nimble reliable reactive and affordable to allow small satellites to embark on their own dedicated micro launcher the cornerstone of these services is zephyr powered by an inhouse designed rocket engine navier and an innovative lowcost launchpad system which allows an easy rescheduling launching from several launchpads without launchpadspecific design and therefore scale economies
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control theorybased testing of cyberphysical systems
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cyberphysical systems cps are engineering artefacts characterised by the integration of software and physical components cps appear in various and critical aspects of human life from drones to wind turbines hence testing their safe and effective operation is of prime importance however due to the combination of physical and software components cps testing requires integrating different engineering disciplines notably control engineering is used at the interface between the software and the physical component and provides mathematical guarantees on the cps safety and performance to overcome the interdisciplinary complexity of cps development this project sets out to integrate control engineering tools and guarantees into software testing practices through this integration i will develop novel testing techniques that allow the engineers to implement safer and more effective cps first i will introduce a novel testing technique based on the assumptions made by control engineers to complement the traditional use of cps requirements this technique will integrate the guarantees provided by control engineering into the testing process thus this interdisciplinary testing will more effectively target critical cps execution scenarios second i will introduce the use of the frequency domain for the test case generation and output evaluation traditional cps testing methods use the time domain to define input sequences and describe desired cps properties as it is closer to the natural language however the time domain has limitations in terms of expressiveness of the relevant properties and in the computational complexity instead the frequency domain is widely used in control engineering as it suits the analysis of the differential equations that describe the physical component i will overcome the timedomain limitations for test case generation and evaluation by complementing its use with the frequency domain
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forensic intelligence and remote sensing technologies for nature conservation
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biodiversity is under severe pressure due to a myriad of problems including but not limited to habitat fragmentation overexploitation climate change pollution invasive species and hunting changes in land and sea use can lead to conflict situations with production animals andor human communities humanwildlife conflict the exploitation of natural resources brings with it illegal activities poaching of species of flora and fauna that have a high value on the black market trading of rare and exotic animals and plants and setting fire to forestry and nature areas to force landuse designation changes to agriculture or commercial uses to ensure that ecosystems are healthy resilient to climate change and rich in biodiversity to keep delivering the essential range of services we need better understanding of why and where biodiversity is declining and what the key triggers are we propose a modeldriven and continuous form of ecosystem monitoring by assessing not only numbers of species and state but also the modelled ecological and anthropogenic processes within an ecosystem we are able to find causeeffect relations and improve our monitoring models based on retrofits and simulations to understand changes even better the models digital twins are thus a means for learning and the creation of context to translate environmental observations into facts and actionable information intelligence for site managers and policy makers as almost all pressures on biodiversity are maninduced we combine the domains of ecology and forensic science this novel approach gives us access to robust scientific methods to detect and recognise traces of human illegal activities that negatively affect the environment we will make use of remote sensing data science eg ai semantics to ensure that theory models and practice reinforce each other we use an iterative approach including many demonstrations and fieldtests to gain feedback and maximize impact
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automated clinical platform for personalized antibiotherapy in critical units based on surface enhancement raman spectroscopy
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sepsis is a leading cause of death in hospitals resulting in 700k deaths in europe each year patients urgently require critical care and are admitted to an intensive care unit icu where they are treated with antibiotics however antibiotic dosing is inappropriate in 50 of sepsis patients causing poor clinical outcomes due to increased adverse events neurotoxicity and contributing to antibiotic resistance antibiotic dosing can be significantly improved through therapeutic drug monitoring tdm but current workflows for drug quantification in clinics and icu are slow expensive and inflexible which have greatly limited tdm implementation we develop acusers a firstinclass highly flexible fast and costeffective system that fully automates the biological sample pretreatment analyte separation and analysis and provides a quantitative antibiotic drug level concentration in 15 minutes acusers breakthrough technology combines centrifugal microfluidics with an integrated surfaceenhanced raman spectroscopy sers chip to perform labelfree rapid detection and quantification in an easytouse benchtop device based on the h2020 sersing project this project builds on developing the ramanbased analyser device and the optimal cartridge as well as validating the scalability of the product and the system with clinical samples from the commercial side we will validate the commercial potential of our solution found a spinoff company to commercialize the technology and make it investmentready we envision that the spinoff will generate early revenues from direct sales in our initial target markets within the eu after demonstrating market traction we will seek to close a global distribution deal with a large diagnostics company for the tdm antibiotic market revenues will be reinvested to adapt acusers for tdm applications in other potential markets such as antiepileptics immunosuppressants and applications in pharmaceutical research
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demonstration and modelling of nbs to enhance the resilience of mediterranean agrosilvopastoral ecosystems and landscapes dryad
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mediterranean agrosilvopastoral ecosystems maes such as dehesa in spain montado in portugal meriagos in italy valonian oak forests in greece provide essential environmental services and influence significantly local communities and their economies maes are expected to be severely affected by climate impacts and extreme conditions such as droughts high tree mortality and wildfires addressing these challenges requires supporting local communities and authorities with local solutions and transformations towards climateresilience this dryad proposal supports the mission adaptation to climate change by developing and implementing reallife climateresilient naturebased solutions nbs for maes dryad combines frontline scientific technological social and business innovations as well as transformative solutions the proposal will be centered around development testing and demonstrating nbss in 5 demonstration regions including andalusia and extremadura es alentejo pt sardinia it and aetoloakarnania el 5 in cohesion fund regions the most promising nbss will be transferred to these 3 replicating regions castillaylen es occitanie fr and tuscany it furthermore dryad will support a multilevel and crosssectoral integrated and adaptive management governance via development of decision support systems dryad will mobilize regional and local authorities and stakeholders that own the climate challenge research entities privatepublic foundations companies citizens and involve them in cocreation coimplementation and covalidation processes by means of living labs this will lead to the creation of real widely reapplicable solutions with longlasting impacts the project will provide tools and implementation guidelines to promote sustainable and climateresilient practices and facilitate regional adaptation plans contributing to the nature restoration law in terms of resilient nature and climate adaptations
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twinning for building excellence and innovative solutions in flow catalysis
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developing continuous production systems through efficient biocatalytic processes flow catalysis supported by artificial intelligence is a key paradigm in advanced and sustainable manufacturing flowcat aims to address these challenges by fostering collaboration between university of ljubljana ul and leading international research groups in the field of flow catalysis by twinning with politecnico di milano university of bari aldo moro university of graz ku leuven and sustainable momentum sl ul seeks to facilitate knowledge exchange and research cooperation on harnessing biobased raw materials for the continuous production of valuable compounds flowcats objectives include knowledge and skillset transfer through workshops summer schools and onsite training focused on junior scientists this aims to enhance uls research excellence project management and administrative capabilities ultimately increasing its competitive research funding and fostering stronger ties with industrial stakeholders flowcat is committed to the wide dissemination of project outcomes research findings innovative methodologies and best practices will be shared through scientific publications international conferences and dedicated project workshops openaccess repositories will also be utilized to make research outputs readily accessible to the global scientific community furthermore the project places significant emphasis on the exploitation of results intellectual property generated during the project will be managed strategically to ensure both academic and commercial benefit aligning with the projects goal of contributing to advanced and sustainable manufacturing practices flowcat envisions a transformative impact on continuous chemoenzymatic synthesis with the potential to significantly reduce industrial pollution material consumption and energy usage these ambitions are harmoniously aligned with slovenias sustainable smart specialisation strategy
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carreras postdoc program empowering future leaders to fight blood cancers
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carrerasleaders is a new innovative and international postdoctoral programme designed by josep carreras leukaemia research institute ijc an independent nonprofit biomedical research institute that is part of the government of catalonia network of research centres cerca ijc is the first european institute exclusively devoted to leukaemia and other malignant blood diseases the aim of the programme is to fund 16 excellent postdoctoral researchers for a period of 36 months the selection of the fellows is meritbased founded on peer review in an open and transparent selection procedure carrerasleaders is addressed to boost career perspective of researchers from a threedimensional perspective leadership independence and consolidationthis is a worldwide unique postdoctoral program that covers the entire spectrum of research and innovation in blood cancers and goes from understanding disease biology to the implementation of products and processes in the market and into the clinical practice through the development of a global translational approach applicants will have complete freedom of research choice within the scope of blood cancers and will be offer highly attractive working conditions and a healthy inspiring and creative working environment carrerasleaders is designed based on the following objectives 1 training the next generation of scientist leaders to advance on the cure of blood cancers multiplying each ones skills sets and networks via targeted career development plans and mentoring2improve the quality of blood cancers postdoctoral research training more targeted addressed to the researchers and societal needs 3enhanced cooperation and transfer knowledge between sectors and disciplines4enable outstanding junior researchers to develop their research careers to an advanced and more independent level in a leading institution such as ijc 5increase the competitiveness of the ijc blood cancers community
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gogreennext promoting future health in ciites
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gogreennext will deliver a comprehensive evidencebased policy oriented approach model to convey how ecosystem health and human health are connected we propose to follow the pathway outlined foa complex array of interrelated problems arising from climate change and biodiversity loss pose significant health risks both today and in the future future risks from climate change are currently predicted to escalate beyond planetary boundaries and pass critical tipping points with irreversible changes to our climate with commensurate negative impacts on health our ecosystems and our landscapes global european and national policy frameworks have emerged in recent years to address this challenge with a range of initiatives to promote mitigation adaptation and resilience naturebased solutions nbs or actions to protect sustainably manage and restore natural and modified ecosystems that address societal challenges effectively and adaptively simultaneously benefiting people and nature are among the strategies that have emerged to reverse the degradation of nature notably in urban areas where changes are amplified in cities vulnerability to climate change and environmental degradation is high due to dense populations critical infrastructure and atrisk communities eg vast differences across socialeconomic gradient cities offer an opportunity to accelerate the implementation of current solutions aligned with emerging strategies and policy initiatives eg new european bauhaus 100 climate neutral and smart cities combining to form what is termed a just green transition this refers to a process of farreaching sociotechnical change leading to a green and climateneutral economy that preserves biodiversity and ensures social justice gogreennext will address the biodiversityclimateplanetary health nexus delivering positive policy and cityregion pilot outcomes in 4 biogeographic regions across europe and with input from best practice globally
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fame openended manipulation task learning with fame futureoriented cognitive1 action modelling engine
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the realization of computational models for accomplishing everyday manipulation tasks for any object and any purpose would be adisruptive breakthrough in the creation of versatile generalpurpose robot agents and it is a grand challenge for ai and roboticshumans are able to accomplish tasks such as cut up the fruit for many types of fruit by generating a large variety of contextspecificmanipulation behaviors they can typically accomplish the tasks on the first attempt despite uncertain physical conditions and novelobjects acting so effectively requires comprehensive reasoning about the possible consequences of intended behavior beforephysically interacting with the real worldin the fame project i will investigate the research hypothesis that a knowledge representation and reasoning krr frameworkbased on explictlyrepresented and machineinterpretable innerworld models can enable robots to contextualize underdeterminedmanipulation task requests on the first attempt to this end i will design implement and evaluate fame futureoriented cognitiveaction modelling engine a hybrid symbolicsubsymbolic krr framework that will contextualize actions by reasoning symbolicallyin an abstract and generalized manner but also by reasoning with ones eyes and hands through mental simulation and imagisticreasoning realizing fame requires three breakthrough research results1 modelling and parameterization of manipulation motion patterns and understanding the resulting effects underuncertain conditions2 the ability to mentally simulate imagined and observed manipulation tasks to link them to the robots knowledge and experienceand3 the ondemand acquisition of taskspecific causal models for novel manipulation tasks through mental physicsbased simulationsto assess the power and feasibility of fame i will use open manipulation task learning as a benchmark challenge
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reactivity of dinitrogen and hydrocarbons for cn bond formation
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the activation and functionalization of dinitrogen under mild conditions remains one of the major challenges of contemporary chemistry despite being the most abundant form of nitrogen the strength of its triple bond renders it highly unreactive thus very few and not yet efficient systems mediate its functionalizationthis proposal entitled readhy reactivity of dinitrogen and hydrocarbons for cn bond formation aims to achieve the catalytic formation of cn bonds from dinitrogen and inactivated hydrocarbons by iron catalysts stabilized by novel bifunctional diketiminate ligands the project is very ambitious both synthetically and conceptually but it builds on solid preliminary work and the expertise of the host groupsthis original msca project will offer cuttingedge science on the road to fulfil the longstanding goal of efficient dinitrogen functionalization for the synthesis of ncontaining organic molecules with longterm technological economic and societal benefitsreadhy will be developed by the candidate at yale university united stated outgoing phase and the university of seville spain incoming phase under the supervision of prof p l holland and dr j campos respectively the project combines ligand design advanced organometallic studies and important applications in dinitrogen chemistry moreover the dynamism of the host groups and the training plan offer ideal conditions for the researcher to enhance its potential towards the start of her independent career
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deconstructing intestinal immune tolerance
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the intestinal tract is the main site of nutrient absorption and faces constant exposure to complex environmental stimuli intestinal barrier integrity and functionality are safeguarded by the intestinal immune system which must balance its pro and antiinflammatory activities to provide protection from pathogenic microorganisms while preventing unwanted reactivity to selfantigens commensal microbes and dietary components the intestinal immune environment can be viewed as a multicellular network in which the identity and function of individual cells is intrinsically programmed by transcription factors tfs that regulate their gene expression these cells in turn can respond to signals in their environment and impact the behavior of their neighbors which over time drives changes in tissue physiology conventional genetic knockout approaches offer insufficient temporal resolution to dissect these regulatory layersin this proposal we will employ chemical genetic protein degradation using the auxininducible degron 2 aid2 system to deconstruct the intestinal immune regulatory network these studies will focus on the role of foxp3 regulatory t treg cells whose continuous immunosuppressive activity is required to prevent the onset of intestinal inflammation in aim 1 we will use newly generated mouse models to probe the direct gene regulatory functions of key tfs that define intestinal treg cell subsets in aim 2 we will fluorescently label intestinal treg cells and rapidly degrade the tfs that confer their suppressive activity to study their functionality in situ finally in aim 3 we will use a reversible mosaic protein degradation strategy to study how the signals that precede and promote intestinal treg cell differentiation shape the developing intestinal immune system together these studies will provide fundamentally new insights into the regulatory network underlying intestinal immune tolerance
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fundamentals of combustion safety scenarios for hydrogen
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hydrogen is a powerful energy vector but its deployment at the scale considered today by governments and companies cannot be achieved if safety associated to combustion hazards is not mastered and regulated hydrogen leaks occur and lead to fires and explosions which must be prevented to do this regulations are needed but these regulations are based today on an incomplete understanding of the fundamental mechanisms controlling the combustion of hydrogen in air or have to consider new usages of hydrogen such as transportation aircraft trains cars safeh2 combines theory highprecision experiments and simulations to provide reliable knowledge on the ignition propagation acceleration mitigation of hydrogenair flames in three canonical cases flames stabilized on a hole flames interacting with a wall explosions in closed vessels the proposal gathers 1 imft where two experimental sites dedicated to hydrogen will be used for low 40 kw and high power 300 kw experiments and 2 cerfacs which provides the highperformance 3d simulation tools used to compute all imft experiments experimental diagnostics coming from the aerospace field will be applied to safety scenarios at imft to validate simulation tools safeh2 will focus on generic simple cases to tackle the fundamentals of hydrogenair flames so that simulation tools incorporate correct validated physical models and can replace costly and dangerous experimental tests all safeh2 experiments will be designed to be used for simulation validations these detailed comparisons between simulation experiment will be used to test models for 1 hydrogenair chemistry in the gas phase and near walls 2 autoignition and plate ignition 3 flameturbulence and flamewall interaction and 4 transition to detonation safeh2 will deliver fundamental science but also models for all simulation codes used in industry and regulation agencies to understand and regulate combustion safety for hydrogen
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distributional effects of environmental policies
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a key goal of environmental policy is to ensure sustainable choices and investment for the individual revising choices and behavior might be necessary to avoid costs or obtain benefits introduced by policies though a growing literature has investigated how different environmental policies produce winners and losers through differences in costs and benefits between individuals less is known about the causes of varying adaption to new policies in the context of environmental policy there are no studies of how the hand of the past determines the ability to adapt through choices that are not easily reversed such as location and exposure to wealth effects from revaluation through existing endowments at the individual or firm level the goal of deep is to provide new knowledge of how existing differences interact with environmental policies in shaping choices with consequences for policy effectiveness and the evolution of disparities among households and firms the key to achieve this is the construction of novel and exceptionally ambitious models of decisions that affect outcomes over time combined with data of unparalleled detail on choices outcomes income and assets of individuals households and firms in settings featuring rich and highly relevant policy interventions the results will contribute both to our understanding of how inequality develops under policy choices in interaction with preexisting disparities and our understanding of the tradeoffs between equity and effectiveness when designing policies the project will center on two strategically important areas 1 electrification of transportation where existing vehicle location and wealth of households influence policy impact with implications for wealth and welfare over time
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engineered carrier transport in nanostructured semiconductors using functional disorder
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disorder is generally considered to have a purely negative impact on carrier transport and most efforts aim to minimize it however recent studies suggest that disorder may enhance carrier transport via carrier funneling along energetic gradients or promote carrier interconversion at defect sites critically though before disorder can be exploited for improved optoelectronic performance of nanomaterials a better understanding of the relationship between disorder and transport is needed envision aims to build a bridge between fundamental observations of the benefits of disorder and materials engineering to enable this i have designed a twofold strategy focussed on 1 defining the detailed design rules for the rational design of disorder driven carrier transport and interconversion and 2 develop strategies to engineer the local energy landscapes of nanostructured semiconductors that boost carrier transport and interconversion to enable the definition of the detailed design rules i will take the crucial step of developing hyperspectral transient microscopy the first superresolution technique capable of simultaneously visualizing the transport of carriers in space time and energy using metalhalide perovskites as a versatile testbed envision will make critical advances beyond the current stateoftheart in promoting carrier transport along compositional gradients boost carrier interconversion at local dopants site and the creation of ondemand energy landscapes using nanoindentation through its unique approach envision will introduce the concept of functional disorder paving the way for new formalisms nanomaterial engineering and guiding the realization of fully optimized energy landscapes for optoelectronic and photonic technologies
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affordable tandem cell architecture by multithinepitaxy approach
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climate change is one of the greatest challenges of our time it is essential to drastically reduce greenhouse gas emissions we need more and better photovoltacis pv to drastically reduce the co2 emissions pv will need to be widely distributed to be able to replace the enormous and growing amounts of conventional electrical energy availability of surface areas allocated to pv preferably close to the end use of the electricity will become an issue reliability and a high energy yield per area will become important for the success of pv products europe presents higher complexity than other regions because of its limited space and highdensity population current silicon technology is basically limited by its single junction one semiconductor bandgap to efficiencies below 30 multijunctionstandems using more than one semiconductor diode aiming at different energies in the spectrum are the demonstrated path to overpass this limit and achieve efficiencies close to 40 as done for three junctions 3j on iiiv and with 35 achievable by using a si bottom junction 3j gainpgaassi two tandems technologies have emerged as promising to upgrade the current si technology perovskitessi and iiivsi iiivsi presents the highest efficiency and stability 2030years but two orders of magnitude higher cost the atacama project will develop the top junction for a iiivsi tandem algaassi with a drastic reduction in cost for the iiivs by 1 ultrathin absorbers using lowcost nanostructuring and 2 substrate multithinepitaxial enable by a novel epitaxial liftoff process furthermore the iiivsi tandem has to attain a high efficiency 303 that will ensure a costeffective solution nevertheless the tandem must ensure circularity recyclable path to split the si from the iiiv by gluing with transparent polymers with a melting point of 200c ensuring the possibility of easily recycling in the future the algaas cell from the si cell
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developing the next generation of environmentallyfriendly floating wind farms with innovative technologies and sustainable solutions
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floatfarm aims to significantly advance the maturity and competitiveness of floating offshore wind fow technology by increasing energy production achieving significant cost reductions within the design and implementation phases improving offshore wind value chain and supporting eu companies in this growing sector ultimately floatfarm aims to decrease negative environmental impacts on marine life and to enhance the public acceptability of fow thereby accelerating the eu energy transitionto this end a number of critical technologies have been identified as key catalysts they apply to different conceptual scales from individual floating offshore wind turbine level action 1 to farm level action 2 and environmental and socioeconomic perspectives action 3 innovations will be introduced into 1 rotor technology where innovative rotor designs for improved energy capture will be explored in a codesign approach with innovative control techniques improved floaters and a groundbreaking generator concept 2 mooring and anchoring where shared mooring and innovative dynamic cabling will be investigated 3 wind farm control where novel control strategies will be exploited to increase the farm power density and 4 environmental impact mitigation where marine noise emissions and impacts on marine species of fow farms will be addressed innovative artificial reefs will be pioneered and social acceptance will be studiedto ensure that effective solutions are pursued and trl5 can be achieved floatfarm adopts a holistic approach that combines innovative designs experimental demonstration at laboratory scale modelling with a suite of beyond stateoftheart numerical tools and demonstration in a unique opensea laboratory where a new 17 scale 15mw fowt will be tested in combination with novel floaters moorings and controls ensuring systematic assessment and validation that are thus far unprecedented in fowt research
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deciphering the molecular mechanism of inflammation orchestrated by keratinocytes during staphylococcus aureus infection in the skin
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the skin provides a physical and immunological barrier to external environment and its homeostasis depends on interactions between keratinocytes peripheral nerves immune cells and microbiota one of the bacteria that can colonise skin is staphylococcus aureus and it can be part of healthy skin or pathogen causing skin infection importantly in atopic dermatitis patients which suffer from impaired skin barrier and microbiota dysbiosis s aureus is associated with severity of flares and exacerbation of inflammation the inflammatory loop in the skin depends both on host and pathogen factors but it is not fullyelucidated how this interaction is regulatedthe proposed project will investigate novel mechanisms regulating the inflammation induced by s aureus skin infection the main focus will be on molecular mechanisms and regulation of pathogen sensing by keratinocytes first murine model of topical skin infection will be used to characterise how keratinocytes orchestrate immune response then it will be examined in detail which s aureus virulence factors induce inflammation in keratinocytes using different laboratory and clinical s aureus strains finally the role of characterised virulence factors and immunomodulators secreted by keratinocytes will be investigated in keratinocyteimmune cells interactions to achieve the goals of this project proteomics nextgeneration sequencing biochemistry molecular biology and immunological assays will be appliedoverall this project will contribute to greater understating of s aureushost immunity interactions with particular focus on regulation of keratinocyte inflammatory response moreover identified novel signalling molecules in the skin and virulence factors of the pathogen can be explored in novel skin inflammation and infection treatments
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advanced tools for integration and synergistic interconnection of microbiomes in resilient food systems
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tribiomes vision is to develop and implement a systemic solution to transform current food production systems to this end tribiome aims to advance alignment with the green deal and farm2fork strategies by deepening the knowledge of soilplantanimal and human microbiomes as well as their interrelationships and interconnections so that they can play a leading role in the resilience of food production systems in the near future tribiome will face the main challenges such as the need to minimize resources reduce the environmental impact and promote healthy and plantbased food chain while feeding a constantly growing world population under the paradigm of climate changethis project aims to drive this concept from its base establishing its central nucleus in current agricultural production systems based on the relevancy of the soil and plant microbiome in order to produce more with less through knowledge of microbial biodiversity and its interaction with the plant developing novel technologies to influence its modulation ie those enhancing plant growth nutrient use efficiency abiotic stress tolerance and better nutritional and health quality of food products in such a way as to generate an upgrade quality food and have a positive influence on the microbiomes of both animals and humansto this end we will work cooperatively in a multiactor approach framework with all actors in the food production systems chain from farmers to consumers industry investors and policy makers in order to develop systemic solutions that guarantee their implementation and solve the real problems and needs of society
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nomad movements and digital impacts in cities
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over the past decade the expansion of the socalled platform economy has accelerated the digital transformation of our daily lives at the same time a cohort of new workers linked to these platform economies characterized by high levels of geographical mobility are central actors in the transformation of consumption patterns urban lifestyles leisure activities and work culture in numerous cities across the globe nomadic is a training and policyoriented project involving an international crosssectoral and interdisciplinary network that aims to promote an adaptive inclusive sustainable and equitable urban future thereby reducing inequality and segregation in the selected cities and beyondobjectives to understand the dynamics and impact of digital nomadism in urban environments to build a network of stakeholders and experts to develop policy guidelines and best practices to design strategies that promote sustainable and inclusive urban environments provide excellent training and supervisionnomadic raisesa explore and characterize the lifestyle consumption and everyday life of hightech and gig workers and their connection to sociocultural urban changeb analyze how these new social practices are related to the platformisation of urban lifec formulate digitalrelated engagement and empowerment actions for community liveability and social inclusion seeking an adaptive inclusive sustainable and equitable urban future that aims to reduce inequality and segregationnomadic is an international intersectoral and interdisciplinary network from across europe and the americas that will join forces to develop a crosscutting study that explores and understands the multiple impacts of digitalization platformisation and the emergence of technological nomads on urban life
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accelerated additive manufacturing digital discovery of a new process generation
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additive manufacturing am by laser powder bed fusion lpbf has the potential to revolutionize future product development design and supply chains since the underlying multiscale physics are not well understood its potential can presently not be exploited suboptimal process conditions lead to severe defects on different scales rendering parts unsuitable for use critically known regimes of stable processing go along with very low built rates ie very high costs compared to other processes this limits lpbf to selected high value applications such as medical devices but prohibits applications in mass production where it otherwise could allow for entirely new technologies excelam aims at the digital discovery of novel highthroughput process regimes in lpbf to increase build rates by at least one order of magnitude computational modeling would be perfectly suited for this purpose since it allows to observe physics that are not accessible to measurement and to study novel process technologies that are not feasible with existing hardware unfortunately existing computational tools are by far not powerful enough given the complexity of lpbf therefore excelam will develop novel gamechanging methodologies grouped into two main classes first novel highfidelity multiphysics models will be developed capturing the complex multiscale nature of lpbf these are combined with cuttingedge high performance computing schemes allowing for predictions on unprecedented time spans and system sizes second novel databased learning approaches will be developed to enrich the physical models with process data while exploiting the manifold of existing data as effective as possible based on these cuttingedge tools excelam will push the limits of lpbf moreover by making them publicly available excelam will help scientists and practitioners in the field of production engineering and beyond to face the technological challenges of the 21st century
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asymptotic speedups for free through automatic incremental computing
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the energy consumption of data centers and ict devices grows at an alarming rate and will be responsible for up to 20 of the global energy consumption by 2030 to sustain the ongoing digital transformation we must find ways to run software dramatically more efficiently a promising direction is incremental computing incremental computations react to input changes rather than recomputing their result from scratch which is known to deliver asymptotic speedups in theory and orderofmagnitude speedups in practice however current approaches to incrementality have limited applicability they either require expert knowledge or only support specialized domains eg database queries or only yield modest speedups the goal of this project is to develop a methodology for automatically incrementalizing computations and significantly improving their time and energy efficiencythe autoinc project achieves this ambitious goal by establishing a novel foundation for incremental computing in three complementary parts first the project develops a library of incremental operators for atomic and other essential data types as part of a novel framework of differential theories which ensure the correctness and composability of the operators second the project designs a lowlevel intermediate representation ir for describing compositional incremental computations as computation networks and provides a novel differential recomputing semantics for the ir third the project develops an optimizing compiler that translates existing code to the lowlevel incremental ir and uses operators from differential theories where possible each part is useful in its own right but together autoinc enables developers to automatically incrementalize the reactive parts of existing programs besides improving the efficiency of programs this project will produce fundamental insights about the nature and limits of automatic incremental computing
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gut microbiota drug biotransformation as a tool to unravel the mechanisms of metabolic microbiotahost interactions
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the variability of the human gut microbiome entirety of microorganisms inhabiting the intestine far exceeds human genome variability and has been connected to various aspects of human health although microbiome differences are often linked to altered metabolism the current view on metabolic interactions between the microbiota and the host remain mostly descriptive due to several limiting factors first most sequencingbased human microbiome studies rely on correlative analyses between microbiome composition and human phenotypes depend on largely incomplete microbial genome annotations and are not targeted to identify communitymediated functional traits second many metabolites can be both of microbial and human origin which makes it conceptually and methodologically challenging to disentangle metabolic microbiotahost interactionsto overcome these limitations i propose a systematic bottomup strategy to mechanistically study metabolic microbiotahost interactions by harnessing gut microbiotas capacity to biotransform chemically modify drug molecules the large chemical diversity and exogenous origin makes medical drugs ideally suited for experimental in vitro and in vivo approaches to probe microbiotahost interactions in a controlled way we will combine highthroughput culturing protocols genetics metabolomics measurements genomics analyses gnotobiotic mouse work and computational modeling to connect interpersonal differences in microbiome composition to differences in metabolic functions of individuals gut microbiota and ultimately link them to molecular host phenotypes generating these mechanistic insights and transformational resources is essential to understand the fundamental principles of the microbiotahost relationship in addition this project has direct medical relevance as it provides actionable microbiomebased links to interpersonal differences in medical drug response which remain a widespread problem in clinical practice
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the anarchist translation flows and world literature project argot
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anarchist periodicals worldwide historically offered readers an uncommon and often outlawed experience of world literature yet their countless literary translations as well as the editors and translators involved in this circulation have been largely ignored by anarchist literary and translation studies data driven approaches along with the rise of digital archives make it possible for the first time to carry out a comprehensive largescale study of these translations by considering periodicals in multiple languages a wide geopolitical space several port cities in the americas and southern europe and a critical period for both literary and anarchist history 18901910 thus argot will unveil the significant contribution of anarchist periodicals to world literature by taking into account the people who enacted this transfer with a specific focus on women and their role in thriving translation flows argot pursues three main goals 1 to identify the literary translations that appeared in anarchist periodicals in montevideo buenos aires ro de janeiro havana new york lisbon or barcelona 2 to rediscover the cultural mediators involved in these translations particularly women and 3 to address the multilingualism of anarchist communities through a spatial approach these goals will be achieved using an innovative interdisciplinary methodology that combines data mining and computational science anarchist literary and translation history and womens and gender studies by making freely available two openaccess reusable databases on translated texts translators and publishers argot will shift our understanding of anarchist periodicals in the circulation of world literature and shed light on exciting new connections from a personal perspective the mscaif will greatly contribute to my career as a strong and highly skilled researcher in translation literary anarchist studies and digital humanities
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blueremediomics harnessing the marine microbiome for novel sustainable biogenics and ecosystem services
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marine microbial communities perform critical life sustaining functions on earth and represent a vast unexploited treasure trove of bioresources that have the potential to strengthen the european blue economy to unlock this hidden potential as well as responsibly conduct biodiscovery from marine microbes requires multiple developments we need to amalgamate and apply advanced technologies to elucidate the composition interactions and functional repertoire of the marine microbiome while concomitantly ensuring sustainable and equitable exploitation maintaining ocean health and improving ocean literacy through an improved appreciation of ocean microbesto address these needs blueremediomics will 1 develop and provide an integrated bioinformatics platform to explore the marine microbiome potential 2 establish innovative culturomics and highthroughput screening platforms to experimentally exploit consortia of marine microbes 3 apply the platforms to identify and develop natural products derived from marine microbes 4 foster aquaculture and ecosystem services that embody the do no significant harm principle 5 maximise equitable access to ocean microbiome resources and increase awareness of the marine microbiome to a diverse range of stakeholders 6 provide training tools and resources to a variety of stakeholders to achieve these objectives blueremediomics interlinks an advanced discovery platform with applications so designed to facilitate cyclical and iterative crosstalk by federating multiple currently fragmented key data resources the discovery platform will accelerate new product identification and development reduce resource dependence raise consumer benefits and address key societal issues new modalities in access and benefit sharing will be established that balance sustainable and equitable use of marine genetic resources with intellectual property protection
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advancing the combustion of hydrogenammonia blends for improved emissions and stability
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to mitigate the impact of greenhouse gas on the environment and climate the gas turbine power generation industry must rapidly reduce its emissions this requires abandoning the traditional combustion of carbonbased natural gas in favour of carbonfree fuels achieve aims at developing the fundamental knowledge to enable a transition to unconventional carbonfree fuel blends based around h2 and nh3 to achieve zero carbon emissions ultralow nox emissions and stable gas turbine operation achieve proposes a threepronged strategy consisting of a experimental and b numerical activities that will advance the technology readiness level trl up to 4 for practical low emissions combustors for realistic and representative blends of fuels as well as c system level engagement with oems end users and stakeholders experimental campaigns will explore combustor stability limits emissions and fundamental aspects of the combustion of hydrogen blends with the complexity of the experimental burners and operating conditions increasing over time and culminating in tests performed at intermediate pressures and powers relevant for gas turbine conditions numerical activities will address combustion modelling challenges including chemical kinetics fundamental physics governing flame dynamics ushering in new modelling techniques such as artificially thickened flames coupled with virtual chemistry subgrid les models for thermodiffusive instabilities and stability analysis aimed to understand and predict nox formation mechanism lean blow off flashback limits and thermoacoustic instabilities realtime monitoring and predictive capabilities for practical combustion systems will also be developed finally in the third prong engagement with industry oems and other target groups will leverage the results of achieve with the necessary stakeholders to progress the transition to a carbonfree fuels for power generation
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causal pattern analysis of networked economic sovereignty
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the legal concept of sovereignty does not capture foreign trade relations networks or economic clout this shortcoming has resulted from a historical reduction of its meaning since the 1600s this project will analyze legal concepts of sovereignty that developed before that time within six networked cities of commerce bruges southampton rouen lübeck toulouse and florence in the period of 14001620 cities were interconnected through trade routes correspondence and diplomacy legal concepts of sovereignty were crafted bottomup and were more encompassing than the presentday legal concept of sovereignty also for economic relations in the process these concepts absorbed changes within the cities and in the economic relations between cities in the project proposed agentbased and network methods will be used to track down these changes the dynamism of conceptual change at the level of individual cities related to commercial political and social developments which will be assessed with agentbased modelling these developments influenced institutional setups constitutional approaches the organization of trade and policies of access toward foreigners at the level of networks between cities dynamics impacting on sovereignty concepts related to foreign relations and yielded features different to developments within cities network analysis will make it possible to detect the dispersal and weight of sovereignty concepts and whether some concepts underpinned a transnational field of sovereignty causal patterns underlying change will be the outcome of this research into the cities and their networks and these patterns will be used to create an updated legal concept of economic sovereignty
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implementing a new line of defence to avoid the catastrophic collapse of precast buildings
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disastrous building collapses often occur due to the propagation of localinitial failures although effective for small initial failures current design approaches addressing this issue can inadvertently increase the risk of catastrophic collapse propagation after large initial failures the erc consolidator grant endure has introduced a novel fusebased segmentation design approach to overcome this alarming limitation successfully testing a fullscale precast building to validate its effectiveness while this approach can be advantageous for different types of structures its implementation in precast concrete buildings is key to maximizing its impact due to several advantages in terms of efficiency and sustainability precast structures are being increasingly used for highoccupancy and critical buildings incorporating fusebased segmentation in these structural systems would thus provide a new last line of defence against catastrophic failures in the buildings for which the consequences of such an occurrence are most severe however at this stage of development the design of a fusebased segmented precast building requires advanced computational analysis and several iterative procedures that are unfeasible for most building projects such complexity can hinder the adoption of fusebased segmentation in practice therefore truly unlocking the market penetration potential of fusebased segmentation solutions for precast buildings requires costeffective implementation tools and validation across a broader range of precast systems encast aims to bridge these gaps by simplifying design procedures developing userfriendly software performing experimental demonstrations and crafting a tailored exploitation strategy for fusebased segmentation solutions for precast buildings the projects success will lead to wider adoption of robust precast systems helping deliver more affordable and sustainable buildings that contribute to improving societal resilience
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alternative gene ends the crosstalk of rna cleavage and transcription termination
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the human genome contains only 20000 genes however most of them encode multiple transcripts resulting from alternative promoter usage splicing and 3 end selection gene 3 ends can be defined by the positions of rna 3 cleavage or the location where rna polymerase ii terminates transcription alternative 3 ends determine the properties of the encoded protein typically its abundance but sometimes also domain structure as for immunoglobulin m heavy chain which is membranebound or secreted depending on the 3 cleavage site widespread changes in 3 end usage are characteristic of many processes eg differentiation and cancer like neuroblastoma we do not understand what drives this selectivityin this research project i will answer the fundamental question of how the location and timing of rna polymerase ii entering into termination mode impacts on the choice of the alternative cleavage and polyadenylation site aim 1 i will use biochemical and genetic approaches to elucidate the sequence determinant of alternative cleavage and termination aim 2 and investigate sequenceindependent components of alternative termination aim 3 i recently pioneered the measurement of 3 cleavage positions together with locations of transcription termination by a novel transcriptomic method i will apply this method to investigate the timing of changes in cleavage and termination relative to each other on an averaged cell population level and use a new technique to test this for single molecules i will also determine the baseline for cleavage site selection utilizing a newly developed in vitro system combining those unique integrative and separationoffunction approaches will yield a comprehensive view of alternative gene end regulationultimately understanding the complex crosstalk between rna cleavage and transcription termination in alternative 3 end selection will enable the manipulation of this process eg to alleviate diseases such as neuroblastoma
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chemical design of smart molecular2d devices for information technologies
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the final goal of 2dsmarties is to develop a new generation of magnonic devices based on hybrid molecular2d heterostructures in which a precise control of the spin dynamics can be achieved by external manipulation of stimuliresponsive molecules with this aim in mind the project will establish an efficient theoretical and computational framework to guide the synthetic efforts towards the creation of low power consumption and highly tunable nanodevices for information technologies using a chemical approach the recent emergence of 2d van der waals magnetic materials provides unprecedented buildingblocks to transmit storage and process information using spin waves whose quanta are called magnons at the limit of miniaturization we will exploit the potential of switchable organic and spin crossover molecules to act as emitters modulators and detectors of magnons at interfaces formed by this class of molecules and 2d antiferromagnets this will open a versatile route based on smart molecules to face some of the current challenges in magnonics in concrete we will provide 1 a more profound understanding of the hybridization of molecular orbitals on magnetic surfaces as well as the effect of these hybridized states on the spin dynamics of 2d magnets 2 a software package to model magnon dynamics in hybrid materials 3 a deep analysis of strainmagnon coupling effects due to the thermal or lightinduced spin switching in spin crossover systems deposited on 2d materials 4 an efficient quantum transport code accounting for spinorbit torque effects to understand the enhancement of properties in the 2d material when interfaced with a topological insulator and 5 the creation of novel devices as a proof of concept we envision the birth of a new interdisciplinary field namely molecular 2d magnonics with impact in molecular nanoscience solidstate physics and materials science leading to promising longterm applications in information technologies
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designing of multifunctional nanomaterials for lightdriven innovation technologies
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delight aims at excellence of europe in nanoscience and impact in research and development at the highest level the project focuses on multifunctional nanomaterials based on colloidal particles organicinorganic perovskites and organic and biomaterials design and fabrication of these materials for stateoftheart applications requires a high level of interdisciplinarity with expertise from chemistry physics material science engineering nanofabrication and biology combined with the most advanced spectroscopy tools the scientific objectives of delight are to establish a platform of highly versatile functional nanomaterials with the use of machine learning and artificial intelligence for materialdevice development and characterization the focus is on multifunctional hybrids heterostructures and assemblies and to fully exploit their potential for catalysis energy lighting plasmonics and theranostics the research is organized in 3 work packages wps that target nanomaterial development functional composites and indepth characterization and device applications social and training objectives are the education of young researchers in europe on the highest level with emphasis on interdisciplinarity that is fundamental in modern nanoscience the advancement of technological knowhow that enables a sustainable and ecofriendly modern society and promotion of gender equality in the scientific landscape at all levels these goals are implemented in a wp dedicated to training organizing lectures workshops technology transfer and outreach and dissemination eventsdelight assembled an academic team of outstanding excellence which links key players in the eu working on stateoftheart nanomaterials with world leading universities in the us canada and argentina that are known for their unique scientific and technological capabilities and efficient technology transfer
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nanotechnologyenabled deep profiling of the blood and brain proteome at the intersection of neurodegeneration and neurooncology
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nanoneuroomics ambition is to bring together nanotechnology proteomics and blood biomarker discovery at the emerging intersection of neurodegeneration and neurooncology nanoneuroomics proposes a nanotechnologybased innovative solution for the integrative profiling of the blood and brain tissue proteomes to address two interconnected challenges i the unmet clinical need for early diagnostic and diseasemonitoring blood biomarkers for two of the most challenging central nervous system disorders namely alzheimers disease ad and glioblastoma gbm and ii the adgbm inverse comorbidity knowledge gap and intriguing molecular interrelation nanoneuroomics presents a novel approach in which nanoparticles are employed as scavenging agents to uncover brain diseasespecific protein markers in blood otherwise buried under the overwhelming signal of highly abundant molecules nanoneuroomics aims to tackle the technological challenge of discovering highly specific blood biomarkers by longitudinally tracking blood and brain proteomic signals at different stages of disease progression to leverage its full potential the proposed research programme combines longitudinal preclinical studies with human patient clinical validation studies such multidimensional proteomic approaches are expected to pioneer new blood biomarker discoveries and to provide mechanistic insight into the comorbidity of neurological diseases nanoneuroomics attempts to discover a distinct set of dysregulated proteins for each of ad and gbm independently and to unveil overlapping molecular pathways to explain the adgbm inverse comorbidity in a broader context nanoneuroomics aspires to bridge the gap between brain pathophysiology and molecular alterations in the blood across the biological continuum of disease progression the project takes on a multidisciplinary approach and builds on breakthroughs in nanotechnology and omics sciences to advance early detection and stratified medicine
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imaging the topological defects of lightinduced phases in quantum materials
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quantum materials host many exotic and useful phases and harnessing these states has spurred tremendous research effort however the full potential of quantum materials lies in the rich landscape of higherenergy hidden phases those which are not thermally accessible ultrafast laser excitation has recently emerged as a way access these hidden phases leading to the idea of rewriting material properties on demand but these states usually only survive for hundreds of picoseconds thus a key outstanding question remains how can we stabilize lightinduced phases one key mechanism which can stabilize a phase is topology the ultrafast phase transitions induced by femtosecond laser pulses naturally lead to the generation of topological defects these defects which can only relax after propagating until they encounter another topological defect could either offer a route to stabilizing lightinduced phases or impede their formation and have been invoked in both contexts to explain many observations however actually imaging these nanometer scale defects on the femtosecond to nanosecond timescales required for lightinduced phases has not been possible and so the role of topological defects in lightinduced phases remains unclearin knotseen i will perform the first real space imaging of topological defects in lightinduced phases using coherent xuv imaging methods which provide the necessary spatial temporal and spectral resolution to map topological defects at the nanoscale and out of equilibrium i will map the creation propagation and destruction of topological defects in two important cases quenched superconductivity in the cuprates and lightinduced phases in the manganites a novel data analysis approach will be used to distinguish repeatable from stochastic dynamics at the nanoscale knotseen will reveal the mechanisms by which topological defects control lightinduced phases enabling new tools to stabilize and selectively control them
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maximising felement oxidation states
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the applicant is a rising earlycareer scientist with an international reputation in frontier rare earth and actinide science this stg project melds synthesis and electrochemistry with computational and spectroscopic methods to afford a transformative advancement in electronic structure and oxidation state control in felements by advancing our understanding of the design principles which influence the properties of these complexes we propose to maximise their stability and expand beyond the current approaches to isolate molecular lanthanide species in unprecedented high oxidation stateswe target high oxidation state lanthanide ln actinide an and transuranium felement complexes beyond the current stateoftheart by expanding to novel ligand platforms which address all key aspects to maximize the thermodynamic and hence electrochemical stability of these powerful oxidisers we will show that the range limit of tetravalent ln ions available to solution chemistry has not been reachedby accessing high oxidation states we will isolate multiply bonded motifs to lniv beyond ce for the first time including iconic organometallic linkages which offer unique spectroscopic epr and nmr handles with which to probe the bonding in these systems this will be extended to actinide and transuranium elements affording unprecedented opportunities to gain insight into orbital energy vs spatial overlap components in bonding and probe the relative magnitudes of interelectronic repulsion spinorbit coupling and crystal field effects in felementsan stg will provide resources required to bring this ambitious project to fruition we will address the rarity of high oxidation state 4felements and define the chemical properties that can be leveraged to control their electronic structures this addresses the quantum flagship a key horizon 2020 priority area and will train a cohort of interdisciplinary scientists essential for the scientific goals of the eu
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