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expresstec from launch to first mvp
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over 600k annual new cases of breast cancer worldwide carry poor prognosis mutations in the gene pik3ca but since 2020 a targeted therapeutic option piqray alpelisib became available exclusively from novartis however due to the still unsatisfactory response rates the uptake by doctors and the adherence by patients has been limited eligibility is established at present by assessing the pik3ca status in tumour dna via companion diagnostic cdx tests from qiagen and roche however we found that the level of expression of the pik3ca mutations measured in tumour rna associates with prognosis and is more accurate to predict the presence of the final mutated protein the drug targethence we are developing an innovative cdx expresspik that goes beyond the present ones to test the expression of mutations and correctly identify the patients who will benefit from treatment our higher accuracy will increase doctors confidence in prescribing expresspik profitable for expresstec and investors and the better response rate beneficial to patients will promote patient uptake and treatment adherence profitable for novartisthe total global expresspik market is over 600 k patients per year the european patent pending secures the use of mutation expression levels in clinical diagnosis for treatment with piqray and other drugs in clinical trials we are validating the technology and planning to reach the mvp within a yearwomen techeu will support developing our business knowledge and acumen as well as provide the access to the industry and investors network we are lacking we hope to make a change in the survivorship of breast cancer patients whilst setting an example of female entrepreneurship in a region with high unemployment and low biotech investment
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synthetic chimeric antigen receptors hijacking nitrenium ions for targeting therapy and safety of next generation t cell therapy
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chimeric antigen receptor car t cell therapy is a promising approach for cancer treatment with remarkable clinical outcomes car t therapy involves the isolation of patients t cells that are genetically modified with an engineered antigen receptor to attack cancer cellsdespite the great promise the rapid activation and proliferation of car t cells can lead to serious side effects in addition car t therapy is challenged by limited effectiveness difficulties in infiltrating solid tumors targeting of healthy cells cell exhaustion and an expensive lengthy and personalized manufacturing process over the past years researchers have explored many strategies to improve and control car t cell function and to develop more universal car t cell platforms yet an offtheshelf approach that allows full control of car t effector function that is flexible in use and can be obtained at low manufacturing costs is currently not availableto address above challenges i will develop a highly innovative universal synthetic car syncar t cell platform where the antigen receptor is easily adaptable by using synthetic functionalized targeting ligands to control t cell effector function in space and timeat the basis of this proposal lies the use of highly reactive and activatable aryl nitrenium ions for protein modification drug delivery and as novel class of therapeutics i will 1 tune nitrenium ion reactivity for bioconjugation and drug activation 2 use enzymeactivatable nitrenium ion precursors for synthetically modified antigen receptors 3 develop novel nitrenium ionbased prodrug strategies to improve car t efficiency and 4 use innovative bioorthogonal chemistry to control car t activity in time and spacein this work i will develop beyond the stateoftheart chemical biology methods and molecular targeting tools to control potentiate and tune t cell activity with the ultimate goal to broaden the car t targeting landscape to solid tumors and beyond
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macrocycles for drug discovery
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better drugs are one of the most efficient and sustainable ways to improve health care a key strategic orientation in horizon europenew drug modalities such as macrocycles are expected to be a key enabling technology for this strategic perspective the goal of mc4dd is to train the next generation of european medicinal chemists in a multidisciplinary environment to promote european drug discovery competitiveness directly by advancing knowhow on macrocycles and longterm via the skills carried on by the researchers trained in the doctoral network
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holistic capability and technology evaluation and cocreation framework for upskilled first responders and enhanced cbrne response
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countries worldwide amid threats and incidents targeting civilians invest in reinforcing their cbrne related capabilities in europe and in most cases the teams responding first are not trained specifically nor equipped sufficiently to face the kind of hazards to provide the assistance to victims and to follow the decontamination processes that a cbrne incident implies at the same time resources are limited exercises and trainings are siloed per organization lacking of proven procedures and digital tools teamup addresses these challenges establishing a unified framework of evaluating capabilities procedures and codeveloped solutions to be used in cbrne preparedness and response the process results to an innovative toolkit for detectionidentificationmonitoring coordinated operations and efficient and safe sar supported by ar digitally upgraded triage and breath analysis fastly deployable mass decontamination system and monitored people and infrastructure decontamination also it offers incident management and digital training tool for frs and citizens enhancing preparedness and response teamup brings several actors together training centers frs experts and nonexperts identifying their specific needs enforcing in parallel crosssectoral crossborder collaboration and facilitating knowledge sharing through a continues evaluation approach in a rich programme of tabletop smallscale exercises as well as small scale and fullscale trials proving new knowledge on capabilities technology performance and operating procedures the solution will be finally validated in france and in greece through the extensive participation of 8 end userorganizations and a very competitive technical team experienced in eu impactful funded projects aspiring to create a ready to market solution teamup will also contribute by initiating an euwide process on standardizing quantitative and qualitative metrics and procedures for decontamination validation
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boronic acids as a new strategy to boost betalactam antibiotics for the treatment of tubercolosis
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tuberculosis tb is a highly infectious disease caused by mycobacterium tuberculosis mtb one of the most dangerous aerobic bacteria the need for longterm treatments and the increase in drug resistance mechanisms make it necessary to urgently develop new strategies to combat this potentially lethal pathogen betalactam antibiotics bla are the most widely used and safest antibiotics in the clinic and include several classes such as penicillins cephalosporins and carbapenems however historically these agents have not been used to treat tb there are two mechanisms of resistance to bla in mtb the cell envelope rich in lipoglycans which acts as a barrier for the penetration of many drugs including bla and the expression of blac a specific betalactamase enzyme capable of hydrolyze and inactivate the bla recent studies have shown that the combination of meropenem a betalactam carbapenem amoxicillin a betalactam penicillin and clavulanate a betalactamase inhibitor markedly reduced the mtb load in the patients sputum after two weeks therefore giving new hope to the use of bla to tackle the tuberculosis epidemic this proposal aims to develop new compounds that behave as bla adjuvant for antimtb treatment with a dual mechanism of action we will design and synthesize novel boronic acid transition state inhibitors batsis as inhibitors of blac the betalactamase expressed in mtb and investigate whether they can be derivatized to become disrupting agents of mtbs unique outer capsule made of lipoglycans to promote better penetration of drugs into the cell this project will also investigate the possibility of improving the penetration of molecules into the necrotic granuloma formed in vivo as part of the disease process by developing a lipidbased prodrug strategy to achieve these specific objectives the project will be divided into three main work packages involving a combination of biological chemical and analytical expertise
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response of the earth system to overshoot climate neutrality and negative emissions
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the rescue project will improve knowledge and understanding in area c of this call climate and earth system responses to climate neutrality and net negative emissions by pursuing two overall objectives 1 quantify the climate and earth system responses to pathways achieving climate neutrality by carbon dioxide removal cdr deployment with and without temperature overshoot and 2 assess the potential role of cdr in reducing net ghg emissions as well as its potential environmental risks and cobenefitsrescue will expand existing knowledge on cdr methods to design a suite of new global temperature stabilization scenarios at several target values to achieve the first objective new model developments will deliver improved climate projections with explicit representation of cdr portfolios for these scenarios the analyses will be devoted to finding suitable pathways to climate neutrality considering multiple aspects of the earth system response mean climate and extremes sealevel rise global carbon cycling biodiversity and ecosystem services particular attention will be paid to the reversibility of induced changes by comparing scenarios with and without temperature overshoot the second objective will be achieved by analyses assessing various factors determining overall effectiveness impacts and cobenefits of cdr portfolios these factors include cdrspecific co2 uptake cdrinduced biogeophysical climate feedbacks cdrderived nonco2 radiative forcers and the interaction between socioeconomic and environmental impacts eg biodiversity moreover a dedicated analysis will provide key criteria for developing a monitoring system for the effectiveness of cdr portfolio deployments and their potential side effects stakeholders will be closely engaged throughout the project to ensure policy relevance and final update of the results which will be made freely available via existing climate services
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economic legal and ip feasibility studies of exheus vital test
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exheus vital is a unique evidencebased innovative solution that supports hcps in providing personalized treatment plans and recommendations to people suffering from obesity to effectively achieve weight management goals the proprietary technology is based on individuals gene activation analysis that is converted into insightful health intelligence reports which provide information on the health status of the individual allow monitoring of patients overtime and a prognosis of possible pathologies exheus leads to unparalleled health outcomes benefiting the individual and the society by driving costeffectiveness of therapy exheus vital offers advantages such as1the information provided together by the rna sequencing and by the exheus ai technology allows to obtain precise information of the abnormalities in gene expression for each patient this allow a high level of personalization that cant be achieved with other methods to provide the best treatment for a given patient2it allows to increase the adherence to the weight loss treatment increasing the effectiveness of the recommendations3it helps hcps motivate the patient and improve willingness to follow the health recommendations therefore promoting a change in lifestyle habits sustainable over the time4hcps ie endocrinologist primary care physicians can now treat obesity through a clinically validated personalized medicine tool to guide and accompany the patient during its healthy weight loss process5monitoring the evolution of activated genes over time can be done through repeated tests to determine changes in these parametersexheus vital is a fast effective and attractive tool that helps health care professionals hcps to efficiently support patients with obesity in their weight loss goals it has been demonstrated that the delivery of the scientifically proven insights expression levels and changes and recommendations using a digital method will be effective
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mooring lineseabed interaction considering trench development and its application in integrated analysis of floating wind turbines
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offshore floating wind turbine fwt provides an efficient solution to address climate challenge integrated analysis of fwt is vital to reduce the uncertainties in design and save costs in the field seabed trenches dramatically increase the failure risks of mooring system and raise operation and maintenance costs however the mooring lineseabed interaction related to soil erosion and trench development is not considered in design code dnvglst0119 2018 thus two objectives of this project are 1 reveal the trigger factor for seabed trenching due to the mooring linesoil interaction simulate the trench development with time 2 establish the macro element model considering seabed trenching process integrate the model into the integrated analysis tool of fwts eg sesam a total of 3 packages are designed comprehensively in the seabed trenching package conduct 1g erosion test to reveal the trigger factor for seabed trenching wp11 then propose the soil erosion model based on analytical analysis based on 1g erosion test wp12 finally the trench development will be simulated by the trench profile model wp13 in the mooring lineseabed package get the chain resistance by 1g result wp21 establish the macro element model wp22 considering seabed trenching process which can consider the soil degradation erosion removal wp23 in integrated analysis package integrate the model into the integrated analysis tool of fwts eg sesam wp3 the new development of the soil erosion model seabed trench model and macro element of mooring line soil interaction are the new computation tool for scientific analysis integrated analysis tool for fwt will be an important and powerful tool for fwt analysis considering mooring linesoil interaction which will contribute to standards setting this will be a groundbreaking progress and will fill the gaps in the norms and standards dnvglst0119
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stabilising autopolyploid meiosis for enhanced yield
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hybrid breeding has been one of the biggest contributors to yield increase of the last century hybrids are individuals which have genetically different parents which results in a hybrid vigour effect this hybrid vigour effect can confer advantages over inbred parent lines in growth yield and resilience and tolerance to different types of environmental stresses important for securing agricultural production in a changing climate an even greater hybrid vigour effect is possible in autopolyploids which can have up to four different copies of each chromosome than in diploids which have can only have up to two different copies of each chromosome in effect double hybrids can be made in autopolyploids with up to four different parents contributing to hybrid vigour in a single individual however to date the double hybrid effect has almost never been used for breeding most of our crops are not autopolyploids we can induce autopolyploidy through chromosome doubling but this causes meiotic instability where multiple crossovers occur between the four chromosome copies during meiosis this pairing disruption leads to potential loss of chromosomes and chromosome fragments essential for seed fertility and viability although induced autopolyploids are meiotically unstable this is not the case for established autopolyploids in the majority of established autopolyploids a maximum of one crossover per two homologous chromosomes during meiosis is strictly enforced thus achieving 100 pairing and correct segregation of chromosomes into daughter cells i propose to stabilise meiosis in induced autopolyploid brassica rapa turnip chinese cabbage by knockout of crossover promoting genes overexpression of crossover suppressing genes and selection of natural genetic variants stable autopolyploids will be used to produce doublehybrid lines which will be evaluated for hybrid vigour for yieldrelated traits
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adaptive laser beam for additive manufacturing
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the alabama project aims to develop and mature adaptive laser technologies for am the objective is to lower decrease the porosity and to tailor the microstructure of the deposited material by shaping the laser beam both temporally and spatially during the am process the key innovations in the project are to develop multiscale physicsbased models to enable optimization of the am process these process parameters will be tested and matured for multibeam control laser beam shaping optics and highspeed scanning to ensure the quality of the process advanced online process monitoring and closed loop control will be performed using multi spectral imaging and thermography to control the melt pool behavior coupled with wirecurrent and highspeed imaging to control the process to verify that the built material fulfills the requirements advanced characterization will be conducted on coupons and on usecases the matured technology will be tested on three usecases aviation maritime and automotive these three industrial sectors span a broad part of the manufacturing volumes from low numbers with high added value to high numbers with relatively low cost however all these sectors struggle with distortions stresses and material quality the alabama usecase demonstrators will improve the compensation for distortions during the am process reduce the build failures due to residual stresses reduce porosity and improve tailoring of the microstructure overall this will contribute to up to 100 increase in process productivity 50 less defects 33 cost reduction due to increased productivity and energy savings a reduction of 15 in greenhouse gases and enable first timeright manufacturing thanks to simulation process monitoring and adaptive control the end users will insert the technologies while the subtechnologies developed in the work packages will be commercialized this will increase the autonomy for a resilient european industry
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microbial biopesticides to control disease vectors and agricultural pests
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the proposed era chair prof george dimopoulos completed his phd at imbbforth in 1996 and has through a remarkable career path harvard embl imperial college johns hopkins become a worldleader in the field of vector biologymicrobial biopesticides he will establish the microbiopest research team at imbb aiming to develop environmentally safe microbial biopesticides for tackling vectors of human diseases and agricultural pests the research plan includes innovative components and state of the art methodologies for the identification of insecticidal microorganisms elucidation of the nature and mode of action of microbial biopesticide and prototype product development this project and research line coincides with the strategic plan of the imbb director john vontas an experienced researcher in chemical insecticides currently coordinator of two horizon2020 and several industrial projects this project is aligned with his green biotechnology sustainable development goals and the ris3 of the prefecture of crete in a region where agriculture and tourism are the main pillars for the economy microbiopest will be supported by structural reforms such as i the establishment of a biosafety level 3 bsl3 lab for work with vector pathogens ii the allocation of space within the 60m investment by the ebi for research training and innovation center for hosting the sustainable biotechbiopesticide center biopest that will evolve from microbiopest and iii operational procedures that will strengthen the technology transfer capacity of imbb the project will form a powerful and inspiring example of brain gain for the broader eu it will train and educate young scientists towards pragmatic career prospects in academia and industry it will form a unique scientific niche in greece with significant impact on the society via tailored communication platforms for target groups and offer alternative ecofriendly solutions to control insect pests
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iprolepsis psoriatic arthritis inflammation explained through multisource data analysis guiding a novel personalised digital care ecosystem
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psoriatic arthritis psa is a chronic progressive inflammatory disease affecting 12 of the general population while manifesting in up to 30 of people with psoriasis pso the transition from health to psa is currently untraceable diagnosis of early psa is challenging even in pso patients untimely diagnosis is common and contributes to early deterioration of quality of life also increasing the burden of the multiple comorbidities associated with psa in this vein iprolepsis aspires to shed light upon the healthtopsa transition with a comprehensive multiscalemultifactorial psa model employing novel trustworthy aibased analysis of multisource and heterogenous ia indepth health environmental genetic behavioural data digital phenotyping of inflammatory symptoms with emphasis on tracking of motor manifestations using smart devices and wearables novel optoacoustic imagingbased markers of psa in the skin and joints and investigation of the role of mast cells in the psa transition to identify key drivers of the disease and support personalized models for psa riskprogression prediction and monitoring as well as associated inflammation detection and severity assessment to ultimately advance psa diagnosis and care the models will be translated into a digital health ecosystem comprising dependable tools for supporting healthcare professionals in disease screening monitoring and treatment via quantitative explainable evidence and empowering people withat risk of psa with tailored insights and preventive interventions based on actionable factors for educated health management the project will steer its research and development efforts following a trustworthy framework for ethical lawful and robust ai and a usercentered cocreation approach based on constant involvement of key stakeholders during the design development and testing of the digital health ecosystem securing successful integration of the latter in the continuum of care
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transition metal carbides decoration of 3d graphene nanostructures for enhanced electrocatalytic hydrogen production carbodoh2
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the exhaustible nature of fossil fuels places our society in seek for alternative and renewable energy carriers hydrogen has attracted significant attention as it holds the highest specific energy density of any known fuel in addition it is a clean fuel that whose consume produces only water electricity and heat water splitting through electrolysis is an environmentally responsible carbonfree alternative technique for hydrogen generation water splitting takes place in an electrolytic cell or electrolyzer the hydrogen evolution reaction her and oxygen evolution reaction oer occur at the cathode and the anode of the cell producing gaseous hydrogen and oxygen molecules respectively heterogeneous electrocatalysis is a process that can accelerate these electrochemical reactions on the surface of catalysts materials for the production of h2 the design and development of efficient catalysts towards the her is of fundamental importance up today noble metals of the platinum group eg rh pt ru are the most attractive electrocatalysts for her nevertheless the high cost and scarcity of these materials limit their potential applications earthabundant transition metals tm based catalysts also show great potential for the her especially transition metal carbides tmc are very promising materials for this application thanks to their performance and availability in order to increase h2 generation per electrode surface area it is beneficial to engineer catalysts with high active surface area offering an increased amount of active sites the present project is prepared placing this necessity in its core and aims towards the design of novel nanostructured tmcs which can exhibit a very efficient activity towards the her to address this challenge we propose a novel synthetic approach which promotes the preparation of nanoengineered tmcs films standing on graphenebased highly conductive templates that exhibit very high active surface area
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regulatory sandbox for a trustworthy artificial intelligence
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ai applications are on the rise this is the case in terms of both number and value and is coupled with a prominent eu investments in the field and in related research aidriven innovations promise great benefits but also come with clear and concerning risks for data protection that are hard to predict and onlypartially covered by gdpr there is an urgent need to understand if and how regulators should intervene in this clash between ai innovations and data protection regulatory sandboxes are the perfect tool for doing so a regulatory sandbox can be defined as an environment for the testing of innovative products services or processes by selected private actors under the supervision of a regulatory authority their findings can be used to improve future regulation andor support compliance with current regulation rebootai aims at designing a legal theoretical framework to support member states and their data protection authorities in setting up regulatory sandboxes dedicated to the development of trustworthy ai applications this framework will be easily accessible in the form of recommendation guidelines which will be based on both theoretical and empirical research for that purpose the project studies the only two regulatory sandboxes in the european economic area that explicitly address the interaction between ai and data protection those that have been activated by the norwegian data protection authority and the french data protection authority by setting a standard framework for regulatory sandboxes on ai and data protection rebootai will bring about an increased adoption of ai trustworthy applications across europe thus significantly contributing to the horizon europe action horizoncl42021human0102
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forcefree microstructures host intrinsic dynamics of orbital phases in av3sb5 kagome metals
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electron correlations significantly modify electron selforganization in quantum materials resulting in a landscape of competing orders and exotic quantum phenomena the recently discovered av3sb5 family kagome superconductors is an intriguing example of competing correlated orders with robust entanglement as manipulating one order can affect or modify another akin to the unique electromagnetic responses of multiferroics these strongly entangled orders have led to an exciting hypothesis of orbital loop current a prime example of correlationdriven electronic instabilities nevertheless it renders the inherent characteristics practically inaccessible through conventional means as even slight variations in experimental conditions can significantly affect their physical properties our research plan is to examine the novel electronic response of the hypothesized orbital loop current in av3sb5 we will research the intrinsic dynamics of orbital phases and their unique electronic response via 1 atomically engineering the kagome nets with the comprehensive material database serves as the kagome toolbox 2 heatelectric quenching of charge order for effectively tuning the interlayer coupling in a kagome glass state 3 spatial control of chiral domains with optical polarization representing three unambiguous routes for revealing the intrinsic electronic orders in av3sb5these goals are ambitious yet entirely realizable freekagomes research approach is based on a unique forcefree setup that features controllable mechanical and thermal coupling between the focusedionbeam fib fabricated microstructure and its supporting frame based on the extremely soft membrane springs with designed geometry
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specific conjugation of antibodies to lipid photoperoxidised cancer tissues for their immunogenic elimination
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cancer ranks as a major cause of death with 34 million new incidences in 2020 in europe the current cancer standards of care include surgery chemotherapy radiotherapy and as of late immunotherapy none of which have met their expected therapeutic outcome yet photomedical treatments like photodynamic therapy of cancer pdt and photochemical internalisation pci show great promise as effective anticancer treatments both are however limited by the cancer cells left behind causing cancer recurrence and metastasis after recovering from their sublethal membrane injuriesbut what if we could label these injured cancer cells with antibodies thus activating the immune system to eradicate them scalpel will utilize pdt or pci to destroy the bulk of tumour cells while marking the remaining sublethally damaged cancer cells for destruction by attaching antibodies to their membranes bespoke modified scalpel components will be administered to all cells normal and cancerous following local irradiation only the photomodified components will conjugate with our specially engineered antibodies selectively flagging the cancer cells for destruction moreover the immune system will be trained through this process against the specific cancers offering systemic immunitythe high riskhigh gain nature of scalpel is counterbalanced by an avantgarde multidisciplinary research team covering photomedicinephotobiology immunology synthetic chemistry porphyrin chemistry and protein engineering scalpel is expected to revolutionize oncology by offering a pioneering photoimmunotherapy with curative potential in this project we strive to provide a proofofprinciple of the proposed technology in cell cultures but also in laboratory animals with the long termvision of establishing scalpel as a clinical cancer modality
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design of artificial organelles to modulate the astrocyteneuron communication
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the brain is supplied by a complex and vast vascular network whose interactions are difficult to grasp in their entirety the neurovascular unit nvu was thus introduced and represents the minimal functional unit linking the brain and its vessels nvu cells interact closely to maintain the integrity of the bloodbrain barrier and supply the brain with nutrients among these astrocytes play the key role of mediator between the endothelial cells supporting the blood flow and the neurons the astrocyteneuron lactate shuttle is an essential communication pathway and its control is crucial for brain homeostasis and thus brain health the research hypothesis of ancom is that the engineering of astrocytes will allow to modulate their communication with neurons in close proximity cultured in a paperbased nvu model engineered astrocytes can thereby be used to influence neurons behaviour and thus contribute to tune the brains activity specifically artificial organelles will be designed to boost the lactate production in the astrocytes these will be made of silica nanoparticles with lactate dehydrogenase enzyme immobilised on their surface and placed in the cytosol of the astrocytes upon a boosted lactate release a beneficial effect on neurons is predicted either in simple cell cocultures but also in more complex systems for that purpose a dynamic in vitro paperbased model of the nvu containing endothelial cells pericytes astrocytes and neurons will be established moreover by employing a new approach developed by the stdler lab it will even be possible to add active locomotion to these artificial organelles with the aim of targeting the astrocytes through the blood circulation ancom aims thus at offering an easily accessible nvu model able to address many questions in neuroscience contributing to the development of brain therapies this interdisciplinary project will allow me to broaden my skills and start my career as an independent researcher
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ecofriendly smart multifunctional composite coatings for longlasting corrosion protection of magnesium and its alloys
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the world is moving towards sustainable economic growth and green technologies therefore the high specific strength easy recyclability and lightweight of magnesium mg based materials make them potential options to minimize weight save energy and reduce environmental issues however their poor corrosion resistance in aqueous and atmospheric conditions limits their widespread usage in many industrial applications enormous effort has been made to protect mg and its alloys against degradation and improve their service time despite that the questions related to their durability longevity biocompatibility cost and environmental impacts must be resolved this scientific work aims to develop durable multifunctional multilayer composite mmc coatings to provide longterm corrosion protection to mgbased materials durability and longterm protection will be achieved by using ecofriendly materials and considering interfacial adhesion strength between substratecomposite within the multilayers and their surrounding environments mmc coatings will be prepared to protect mgbased materials against corrosion and give a visual response when the coating is damaged to achieve this scientific goal mmc coating will consist of a selfassembled organic layer a polymeric composite containing corrosion inhibitor and sensing agents loaded metalorganic frameworks mof using a stimuliresponsive polymeric gatekeeper in a single layer and a top selfcleaning hydrophobic polymeric layer they will provide adequate longterm corrosion protection of mgbased structures by the synergistic effect of selfcleaning passive barrier layers and ondemand release of active corrosion inhibitors from loaded mof corrosionsensing agents encapsulated mof will monitor the onset of corrosion upon physical damage to the coatings for large area systems mmc coatings will ensure minimum cost and environmental impacts consistent with desired properties and help to substitute pfas
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integrated optomechanical nanoresonators for realtime singlemolecule detection thorugh photothermal spectroscopy
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optical absorption microscopy based on the photothermal heating effect has recently succeeded in detecting single molecules with a temperaturesensitive nanomechanical resonator molecules are sampled onto the nanomechanical resonator and probed with a freespace laser upon scanning optical absorption and photothermal heating of the sample results in a detectable detuning in the mechanical resonance frequency this technique has overcome the main limitations of alternative optical probing methods a remaining challenge of nanomechanical photothermal microscopy is the alignment of the freespace optics with the intersecting molecular sample beam necessary to perform timeresolved singlemolecule spectroscopy furthermore offplane optics limits its possibility to be miniaturized integrating nirmir waveguides in nanomechanical resonators will create an innovative optomechanical device that solves the alignment problem increases the field of view decreases optical complexity and enables photothermal spectroscopy miniaturization avoiding absorption spectroscopy limitations iefabryperot resonances outcoupling and propagation losses we propose to give the first steps towards a complete integrated photothermal spectroscopic device for singlemolecule analysis dispensing with freespace optics in the envisioned design the probing light travels inside the nanomechanical resonator orthogonal to the sample beam resulting in an evanescent interaction with the sample molecules on the surface this design will enable the detection of singlemolecule deposition events from heterogenous samples in particular airborne particles and proteins in solution will be the target analyte due to its environmental and health relevance furthermore the selectivity provided by the spectroscopic measurement allows for identifying and monitoring neoplastic while the device holds potential use for early diagnostics
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researchers and citizens facing together the european challenges
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the european researchers night in madrid will bring together researchers to the general public and will increase awareness of the importance and benefits of research and innovation creating an understanding of the impact of researchers work on citizens daily life and raising young peoples interest in science and research careersthe project will achieve these objectives by means of festive activities to be carried out in the region of madrid in the morning and evening of the last friday and saturday of september 20222023 pre events and post events will be also organized the madrid night project also includes researchers at schools activities throughout the year in these activities researchers will be visiting schools allowing teachers and pupils to engage with them on important topics faced by our societies such as those included in the missions in horizon europe cancer adaptation to climate change healthy oceans seas coastal and inland waters climateneutral and smart cities and soil health and food students and teachers will also visit the researchers workplaces the madridnight activities will be addressed to public at large scienceaddicts and sciencereluctant children families teachers elderly people regardless their scientific background with a special focus on families pupils and students with the main purpose of encouraging stem subjects and science careers university students and also vocational education and training students different activities will be offered focused on the missions in horizon europe the project will involve researchers benefited by eu funds especially the msca the activities will point out the transnational and diversity aspects of research showing the attractiveness of their jobs that can be done everywhere in europe universities research centres museums hospitals ngos foundations and industry spin offs sme or large companies in the region of madrid will be at the core of the project
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bypassing open heart surgery with excimer laser assisted non occlusive anastomosis elana
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we will revolutionise the medical field by replacing expensive invasive and highrisk openheart surgery with keyhole minimally invasive surgery mis to treat coronary artery disease cad our elana technology enables reproducible coronary artery bypass grafting cabg surgery without the need of heart arrest and suturing thus avoiding the need to open the patients chest this is realised with an innovative clip which circumvents the need of suturing of blood vessels altogether by realising closedchest cabg elana reduces not only the risks associated with traditional cabg such as bleeding stroke and wound infection but also significantly shortens recovery times as a result elana will reduce direct healthcare costs of cabg procedures by over 50 to critically derisk our technological development and accelerate market entry to 2025 amt medical seeks a total of 75m funding 25m grant 5m equity to finalise clinical validation and gain market approval
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upscaling innovative green urban logistics solutions through multiactor collaboration and piinspired last mile deliveries
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urbane brings together a multidisciplinary group of 41 partners from 12 different eu member states including 12 cities industry leaders in logistics services novel solution providers for shared connected and automated operations and research experts to codevelop novel last mile delivery solutions combining green automated vehicles and shared space utilisation models the project will support the transition path towards effective resilient safe and sustainable last mile transport through four lighthouse living labs helsinki bologna valladolid and thessaloniki that will demonstrate trl78 efficient replicable and socially acceptable innovative last mile delivery solutions wave 1 lls building on existing trl5 assets handson lesson learning at european level will be primarily facilitated by an innovation transferability platform comprising digital twinning tools open models smart contracts governed by blockchain technology and a datadriven impact assessment radar that will enable the adaptation and replication of wave 1 solutions in two twinning lls in barcelona and karlsruhe wave 2 lls demonstrating their own solutions within the course of the project urbanes commitment to upscaling is further strengthened by the engagement of six early adopters follower cities in innovations adoption feasibility studies thus stimulating the formulation of new ll communities across europe the approach employs social simulation tools to experiment with possible strategies urbane will provide evidence of the real introduction of the physical internet in urban deliveries for the first time
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moral emotions in politics how they unite how they divide
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liberal democracy is struggling with the challenge of citizens indifference and detachment from politics while antisystem politicians are overemotionalising policy issues which furthers polarisation in society the normative stance of mores is that both under and overemotionalisation of politics should be avoided the former leads to the affective disconnect of citizens from politics while the latter spurs tribal politics and hampers deliberation both extremes threaten democracymores argues that moral emotions and moralised political identities a conceptual innovation of the project have a practical value in dealing with the challenges of affective politics moral emotions are linked to the interests or welfare of society or at least of persons other than the subject itself they can unite people towards common causes or split them along moralised political identities mores applies a horizontally wide research logic to build a normativeanalytical framework to inform democratic decisionmaking on how moral emotions should interact with values policies and political practices mores will create stateoftheart methods and generate new empirical data on 1 the type of moral emotions triggered by political actions and phenomena such as campaigns leadership styles and illiberal politics 2 the role of moral emotions in forging moralised political identities 3 the effect of moral emotions on political behaviour such as policy support and civic activism and 4 the contextual social phenomena including digital universes of the moral emotionspolitics nexusthrough research engagement with key stakeholders mores will create several innovative tools including a method for policymakers to measure the emotional valence of policies games to strengthen citizens politicalemotional resilience both in reallife and metaverses and policy ideas to embed citizens moralemotional needs in policymaking towards bolstering trust in democratic governance
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privacy preserving identity management for digital wallet and secure data sharing and processing for cyber threat intelligence data
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prividema represents an industrydriven initiative to advance privacypreserving technologies in the application areas of cyber threat intelligence data protection and identity management this multifaceted project operates across various research and innovation maturity levels with the overarching goal of introducing more robust userfriendly and scalable privacy and security technologies for the european ecosystem key components of prividema include 1 development of opensource tools hosting networking events and initiation of capacitybuilding efforts to democratize technology access and empower cybersecurity professionals 2 advancement of homomorphic encryption capabilities implementation of hardware acceleration methods and improvement of fully homomorphic encryption fhe usability 3 creation and demonstration of a prototype european identity wallet featuring issuer and relaying party functionalities 4 development and demonstration of a prototype european privacypreserving cyber threat data processing system with realworld testing and validation of innovative technologies aligned with the objectives of horizon europe prividema actively contributes to increased cybersecurity data and network protection and the establishment of robust digital infrastructures the project distinguishes itself through its commitment to supporting smes as well as promoting opensource development crossdisciplinary collaboration and privacybydesign principles the solutionoriented approach positions prividema as a pivotal force in advancing cyberresilient digitalization and the data economy in europe prividemas connection to various european strategic initiatives underscores its relevance with a clear emphasis on realworld applications innovation beyond the stateoftheart and a strategic trajectory toward marketready solutions
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hybrid nanostructured systems for sustainable energy storage
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humanity will increasingly need safe clean and always available energy thus having good energy storage systems will be more and more important in the future efficient and sustainable rechargeable batteries are required to power portable electronic devices new hybrid electric vehicles and to store electricity from renewable sourcesthe mission of hynanostore is the development of new environmentfriendly systems based on that organic molecules which are used in the chemistry of life for the storage of chemical energy and its transformation in electrical energy hynanostore rethinks the concept of batterys electrode based on lithium insertion and propose a novel architecture in which the redox properties of biomolecules such as enzymatic cofactors can take up and release ions reversibly in order to overcome the problems safety sustainability and longterm ciclability associated with the use of conventional li ion batteriesto achieve this a nanostructured conductive scaffold with tailored characteristics will provide a framework to immobilize redox active molecules extended surface area to maximize their loading a pathway for the charge transport and a diffuse interface for the interaction with the electrolyte the new bioinspired engineered system developed after the successful completion of hynanostore will offer benefits in terms of power and cyclability an energy density of 500 w h kg1 and the retention of at least 90 capacity after cycling 800 times are expected with the implementation of these systemsthe output of the project hynanostore will be the introduction of a new concept for lithium ion batteries towards cheap green and versatile energy storage devices
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redesigning aortic endograft enabling insitu personalized aneurysm healing
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forty years ago the endograft eg enabled the endovascular treatment of aortic aneurysm aoa and revolutionized vascular surgery still since then its technological concept has remained substantially unchanged eg is a passive device aimed at treating the aoa in its late stage not to cure the disease even when discovered early this proposal introduces a bioengineered process to redesign egs as 3d bioprinted bioresorbable devices loaded with active drug components and validated invitro to enable the paradigm shift from endstage treatment to early personalized healingto this aim epeius must tackle three open challenges 1 available animal models often fail to predict human safety and efficacy for candidate therapies 2 potentially effective drugs are challenging to deliver in therapeutic concentrations at the target 3 consequently there is a limited capacity of aoa healing even for compounds that were preclinically promising we hypothesize that these challenges can be solved simultaneously by designing and fabricating a human invitro model of aoa where we can track aoa progression in the presenceabsence of bioengineered eg delivering therapeutic drugs grounded on a multidisciplinary approach epeius will act as the trojan horse to enable the local healing of arterial wallsto verify our hypothesis we will integrate 3d bioprinting and computational biomechanics to aim 1 create an invitro model of aoa recapitulating dysfunction of endothelial and vascular smooth muscle cells degeneration of extracellular matrix overall driven by inflammatory stateaims 2 create a customizable eg to carry drug insituaims 3 assess invitro the regenerative power of the mesenchymal stem cells secretome to heal aoa epeius will directly tackle a prominent medical issue but we are convinced that this innovation in computeraided engineering additive manufacturing and invitro pharmacology will create the next generation endovascular device
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replicable interoperable crosssector solutions and energy services for demand side flexibility markets
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reeflex aims to generate niches of opportunities for new crosssector energy services provided by smes and startups in demand side flexibility markets and to increase participation of energy consumers in demand side flexibility markets the project develops a central interoperability platform and a catalogue of services with the capability of maximising distributed energy resources flexibility while respecting the different end user profiles and needs along with the physical limitations of existing infrastructures additionally the generation of a common operation market model together with aidriven intelligence services and automation systems enabled through the utilization of distributed ledger technologies for enhancing transparency and trust will reduce market entry barriers and costs and achieve a higher participation from energy consumers they will benefit from new revenues obtained through data and flexibility transactions while enjoying innovative personalized data intelligencedriven services for smart humancentric control of their assets in the frame of demand response or selfconsumptionreeflex solutions they will be demonstrated and crosstested in 4 main demonstrators spain greece switzerland bulgaria with different characteristics allowing evaluation of their impact under alternative scenarios and integrating a variety of sectors such as residential buildings mobility commercial establishments industrial sites or data centres among others in addition the services catalogue will be further replicated in three additional replicators across europe to achieve wider coverage turkey portugal denmark and adaptation endingup in a total of 7 countries for the whole project execution these crosstested demonstrators and additional replication campaigns are structured around 8 different use cases that cover a comprehensive set of consumer groups to participate in up to 12 demand side flexibility services
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delineation of experiencedependent astrocyteneuron cognitive dynamics
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in the brain cells called astrocytes are as abundant as neurons but are much less understood over the recent years we have begun to appreciate how closely astrocytes support the development and function of synapses the proposed substrate of memory one emerging function of astrocytes is their direct involvement in learning and longterm memory indeed astrocytic activity is affected in major brain disorders that affect memory such as alzheimers disease the overarching aim of this fellowship is to study how astrocyteneuron coordinated activity relates to learning and memory i propose that astrocyteneuron activity dynamics are shaped by learning over days to support memory formationto test this hypothesis i will use stateoftheart microscopy and genetically encoded fluorescent proteins both available in the host laboratory to record the activity of large numbers of neurons and astrocytes while mice are trained in a perceptual learning task over days in this way i will be able to see how neurons and astrocytes change their activity in response to learning i will then manipulate the activity of astrocytes using clever genetic tools and light while the mice are being trained and monitor the effects of this manipulation on the activity of neurons and memory performance this step will allow me to establish causal links between astrocyte activity and memory finally i will use modern statistical learning techniques to explore the contribution of astrocytes and astrocyteneuron interactions to the computational capacity of the brain this proposal capitalizes on my strong expertise in rodent behaviour and data analysis my knowledge and strong interest on how experience shapes brain activity and the established microscopy and genetic techniques in the host laboratory overall this project will allow me to acquire new skills and knowledge in microscopy and astrocyte biology and generate testable hypotheses for my future research
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mobility justice for all framing safer healthier and happier streets
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just streets is the project proposal from a team of 30 partners from 17 countries including 12 cities representing more than 45m citizens it aims to transform cities carcentered mobility narratives that take for granted that streets are for motorized traffic only promoting walking cycling and other active modes of mobility just streets will be reshaping street infrastructure and changing individual mobility behavior in 12 cities while proactively sharing the generated howtodoit knowledge with hundreds of cities for rapid replication across europe in close collaboration with citizens policy makers experts and interest groups the project will not only develop a new vision of spatial justice where streets become public space for all but equally important find ways to rapidly implement changes a strong focus is on displaying how necessary transformations in the face of climate change can and must successfully improve social justice accessibility inclusivity and security along the way putting marginalized social groups the most vulnerable mobility users as well as those citizens at the core of just streets that have been previously underrepresented in mobility infrastructure decisionmaking will allow the project to create highly valuable knowhow critical in creating better more just and sustainable cities for all citizensthe unique composition of the just street consortium is critical in making sure this knowledge is not only created but subsequently shared with as many urban decision makers as possible from cities across europe who have the means to initiate transformation in their cities toplevel research and organizations with vast experience in the fields of mobility urban planning climate change and social transformation are collaborating with the communication and dissemination expert partners who have established channels to reach and interact with tens of thousands urban decisionmakers that will shape the future of cities
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botanical concrete new green material for artificial reef
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tourism recreation fishing marine aquaculture and many other economic activities depend on the diverse marine ecosystems globally however a combination of factors such as global warming ocean acidification and increment of cyclones in recent years have led to the aggravating degradation of natural reefs one of the most varied marine ecosystems on earth artificial reefs ar are widely used for habitat restoration ecological development and coastline protection concrete is the most successful ar material but it generates substantial co2 emissions has high contamination and has low bioreceptivity botanical concrete developed by author during phd study is based on the concept of a circular economy with 100 responsible use of waste materials and its carbon negative and nontoxic characteristics provide exciting potential in building the green infrastructure in ocean this research aims to enhance the durability bioreceptivity and versatility of woodwastebased botanical concrete to create a green route for the design of the new generation of multifunctional ecofriendly ar for coastal protection and coral restoration based on nutrition water quality and settlement substrate test in marine environment lablevel the raw materials are selected followed by formation design through advanced simulation computed tomography scanning and experiments on durability and mechanical performance and life cycle assessment the prototype of ar will be tailored to achieve optimal density for easy installation high resilience in storms superior capability for coral larval settlement and biodiversity the results will revolutionize the way in which ars are made and boost the efficient use of recycled resources and alleviate climate change by moving into a clean circular blue economy the project will contribute to the eus sustainable blue economy strategies including decarbonization circular economy biodiversity climate adaptation and sustainable food
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sharp regularity bounds of maximal functions
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in 1997 juha kinnunen proved that maximal operators satisfy a sobolev bound if the sobolev exponent p is strictly larger than 1 his article initiated the study of regularity of maximal functions a field which has attracted several dozens of authors to this day geometric techniques have recently lead to a series of breakthrough endpoint regularity bounds for maximal operators in higher dimensions this project pursues the novel strategy of combining these new geometric tools with already established extremization techniques in order to solve a wide range of open questions in the fieldthe goals of the project are organized around two themes gradient bounds and sharp constants the main goal from the first theme is to prove that the variation of the noncentered hardylittlewood maximal function can be controlled by the variation of the function in all dimensions this is the endpoint p1 of juha kinnunens original bound and is one of the main long standing open questions in the field this project also aims to prove this variation bound for further maximal operators along with the operator continuity of their gradient and bounds for higher derivativesthe main goal from the second theme is to prove that the centered hardylittlewood maximal operator in one dimension does not increase the variation of a function this bound would be sharp because examples show that in general maximal operators do not strictly decrease the variation of a function this project further aims to prove this sharp bound for convolution type maximal operators and to find the sharp constant in the variation bound for the dyadic maximal operator in all dimensions
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european partnership for a sustainable future of food systems
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the vision of futurefoods is to collectively achieve environmentallyfriendly socially secure fair and economically viable healthy and safe food systems fs for europe futurefoods gather 87 partners from 22 eu member states 6 associated countries and 1 third country futurefoods includes public and private actors policy makers foundations locally subnationally nationally euwidelyall these futurefoods partners are fully aligned on the vision for the partnership and the methodology for its implementation in line with sdg17 and eu green deal components this vision has been broken down into general go specific so and operational oo objectives applying across the 4 ri areas and 4 transversal activities identified by the futurefoods consortium in its stable draft strategic research and innovation agenda sria which constitutes the strategic backbone of the project the four go cover go1 functioning of fs go2 system approaches go3 inclusive government go4 cocreation cases these go have then been translated into so prioritised in line with the timescale and resources of the partnership so1 change the way we eat so2 change the way we process and supply food so3 change the way we connect with fss and so4 change the way we govern fsin addition 6 interconnected oo have been set oo1 pooling ri resources and programming oo2 operational fs observatory oo3 active fs knowledge hub of fs labs oo4 functioning knowledge sharing and scaling mechanisms oo5 revisiting the sria oo6 promoting supporting widening gathering fs various communities the objectives implemented in the 8 wps of futurefoods will exert impact directly or indirectly in most of the destinations of horizon europes cluster 6 20232024 work programme and particularly for the topic destination fair healthy and environmentfriendly fs from primary production to consumption echoing to the main eu and world fs policies strategies
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protactus from longterm consequences of road crashes
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battling serious injuries and longterm consequences in road traffic remains one important issue in the overall goal of resilient future road transport vision zero challenges of increasing personal transport in urban areas coupled with autonomous vehicles and shuttles new mobility devices and the overall need to ensure the safety of vulnerable road users as well as all types of vehicle occupants require innovative approachesprotactus project aims at protecting all road user groups from serious injury and longterm physical cognitive and mental health consequences of road crashes through innovatively interlinked research action between medical and engineering methods protactus enables therefore the development of efficient resilient inclusive and effective countermeasures as well as postcrash action for all relevant road transport meansprotactus will work on the following goals and challengesmedical data correlation standardization and classification of longterm physical cognitive and mental health consequences of road crashesrobust and reliable assessment tools and methods allowing for effective countermeasure development for all road usersreduction of longterm consequences and related social cost of road crash related injuries for all road usersthe protactus solutions will influence new standards in respect of extending current injury coding system with relevant longterm aspects for physical cognitive and mental health related injury allowing new physical as well as virtual safety assessment procedures and adaption of rules and regulations to be implemented finally scientifically wellfounded suggestion for future implementation into policy regulatory and standardization guidelines for an inclusive safety improvement approach for in as well as postcrash will be provided
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advancing crossborder coaching and economic support for specialised services
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eicaccess mission is to enable eic awardees and seal of excellence holders to access specialised services offered through the eic service catalogue by offering financial support to partially cover the services price and facilitating the delivery of tailored assistance to address the unique scaling challenges of deep tech european innovators an initial survey will allow to assess the alignment of the pool of services available in the eic catalogue with the needs of the eic community members their availability and accessibility and provide actionable information and recommendations to assure a complete coverage of key categories of needsthrough a permanent public open call for applications up to 180 beneficiaries will be selected to access three categories of service packs from the eic catalogue to answer their specific needs and matchmaking them with eic ecosystem partnership service providers the selection process will be aimed to efficiently assign and distribute the financial support to the selected eic community members as lump sums eicaccess will carefully monitor the service delivery and assess results and impacts for the eic community members through detailed statistics and analytic dashboards making sure that stringent quality standards are respected and reflected through an overall high satisfaction rate and the emergence of success stories to be promoted in the yearly uptake and impact report and more generally through online channels and social mediathe initiative will contribute in close synergy with the eic and the contractor implementing the call for ecosystem partners to making the eic ecosystem partnership stronger by facilitating the service delivery with the financial support providing insights about the service offer availability and impacts and engaging the community in a peer learning and coconstruction process to fill in the gaps and fully cover the needs of the eic community members
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the pressure effects on magnetic properties of an ideal quasi2d planar antiferromagnet bani2v2o8 at the base and finite temperatures
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the pressure attracts noticeable attention in the field of condensed matter physics because it can modify magnetic and electronic properties of the compounds the external pressure can induce both structural and magnetic phase transitions giving experimental access to novel magnetic phenomena this makes pressure a promising tool to customize the magnetic properties of solidstate compounds both at the base and finite temperatures however no comprehensive study has been done so far on the investigation of the pressure effects on overall magnetic properties such as hamiltonian magnetic structure and critical behavior of a model magnetic system i address these issues in the pressmag project which explores the pressure effects on magnetic properties of an ideal quasi2d planar antiferromagnet bani2v2o8 at the base and finite temperatures first i will solve the magnetic structure and hamiltonian of bani2v2o8 under applied pressures and then will study the critical behavior of bani2v2o8 under applied pressures using both neutron and xray scattering techniques in particular the pressmag project will study for the first time the pressure effects on the berezinskiikosterlitzthousless phenomena whose signatures were recently discovered in bani2v2o8 finally the smallangleneutronscattering technique will be used to image the berezinskiikosterlitzthousless vortices in vacuum and under applied pressure
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a novel role for pge2 signalling in promoting aged neuromuscular junctions reinnervation and counteracting sarcopenia
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aging is characterised by a progressive decline in muscle mass and force potentially resulting in the insurgence of sarcopenia sarcopenic patients are at an increased risk of falls and fractures with a concordant decrease in mobility and personal independence evidence suggests that key determinants of sarcopenia insurgence are muscle denervation failure of its reinnervation and degeneration of neuromuscular junctions nmj representing the connection between the nerve and the muscle and essential for muscle function this msca project will inform our understanding on the interplay between prostaglandin signalling and the nmj in the onset and treatment of sarcopenia prostaglandin e2 pge2 stimulates tissue regeneration its levels are reduced in aged human and mice skeletal muscles due to increased activity of its degrading enzyme 15 prostaglandin dehydrogenase 15pgdh inhibition of 15pgdh in aged rodents restores pge2 concentrations to youthful levels increasing muscle mass strength and endurance however the mechanisms underlying how 15pgdhpge2 modulation exerts these effects are not well understood here i will show how pge2 impacts nmj integrity in mice establishing if restoration of its signalling restores nmjs innervation progressively lost in aging my final aim is to determine whether boosting pge2 levels via 15pgdh inhibition represents a viable therapeutic strategy to treat sarcopenia to confirm the relevance of the dysregulated 15pgdhpge2 axis in determining nmj alterations in humans i will perform single nuclei rnaseq and spatial proteomics codex on muscle samples of young and aged healthy presarcopenic and sarcopenic individuals i will integrate the molecular data with invivo muscle morphology and function 1 to reveal whether 15pgdh expression activity and localization is different in sarcopenic muscle and correlates with any invivo parameter and 2 to generate a macrotomicro atlas of human aging and sarcopenia
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evaluation of healthysustainable food proteins
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access to healthy and sustainable foods is an existential priority as recognized by the un who and eu replacing animalbasedproteins with their plantbased counterparts is expected to be a major step forward due to a 28 fold depending onthe species increase in protein efficiency in order to speed up this protein transition methods need to become available toallow for highthroughput evaluation of protein ingredients in terms of technical functionality that rules food properties andphysiological functionality that ultimately decides on effects taking place in the bodythe evaluator project focusses on plant protein properties in colloidal emulsion systems for which a tailormademicrofluidic platform will be developed to dynamically assess technical emulsion stability and digestibility for this wechoose to work with pea and bean proteins that are readily available at low cost within the eu the microfluidic platformallows realtime investigation at micro and nanometre levels the scales at which basic food structure elements are formedand degraded and within very short time spans through highspeed recording therewith closely mimicking the actualprocess conditionsevaluator will not only lead to the design of healthier and greener food systems but also supply a versatile microfluidicplatform that allows design from first principles ie the actual protein properties as they are relevant for food production anddigestion this brings food design that currently revolves around trial and error into a completely different realm and evenmore importantly establishes the currently missing link between technological functionality and digestionthe key for success is the combination of my background in microfluidic design and digestion that of the hosts in emulsionswur the netherlands and the secondment inrae france in advanced digestive systems which allows me to cover allaspects of the evaluator project in a groundbreaking way
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transforming co2 into addedvalue construction products
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the european green deal sets ambitious targets to ghg emission reductions for the process industry that can only partly be reached by the transition to renewable energy residual hardtoabate co2 emissions from industrial processes such as steel and cement production will need to be captured and wherever possible processed and recycled into new products the shift towards low carbon processes may disrupt existing industrial symbiosis pathways if no alternative linkages are developed this may lead to increasing emissions in downstream sectors the transitions in steel and energy production lead to dwindling supplies of low carbon resources for cement production such as blast furnace slag and coal fly ash the core concept of carbon4minerals addresses the simultaneous use of co2 from industrial flue gases with current and future waste streams to unlock a vast stock of resources for innovative low carbon binders and construction materials 80135 lower co2emissions than reference a total of 8 industrial pilots will be built and operated across the process value chain from co2 capture to cement production and low carbon construction products this crosssectorial innovation has the potential to reduce european co2 emissions by 46 mty equal to 10 of the eu process industry emissions while safeguarding the competitiveness of the european industry a consortium of technology providers producers and research partners will develop test and demonstrate the processes technical environmental and economic feasibility will be validated by an integrated assessment in combination with the development of a service life test package tailored to these new products colearning modules are developed to support industrial implementation and market introduction
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rna topology of test samples and single extracellular vesicles how cells package rna messages to communicate rnatop
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in rnatop i will investigate the precise locations and quantity of rna associated with extracellular vesicles eg evrna topology to achieve this goal i will setup innovative liposomebased synthetic vesicle models herafter referred to as test samples resembling evs with a known rna topology i will use these test samples to create workflows for super resolution microscopy srm and spectral flow cytometry sfcm to study rna topology these workflows will be extrapolated to ev samples to define evrna topology of single evs for the first time the research will be conducted in the amsterdam umc under the supervision of dr rienk nieuwland nieuwland and his team have the knowledge experience and technical infrastructure to perform srm and sfcm to study evs therefore rnatop will allow me to deepen my knowledge on evs and gain skills to perform srm and sfcm conversely i will bring my expertise in liquid biopsies and rna obtained during my phd in pangaea oncology in barcelona h2020mscaitn i will carry out a secondment in the lab of dr zoltn varga research center for natural sciences in budapest an expert in the field of creating test samples to get handson training at the end of the project i will join exometry supervised by dr edwin van der pol cso for a 6month nonacademic placement to 1 develop an analysis software to process rna topology data and 2 gain commercialization skills the unique interdisciplinary and intersectoral combination of the participating organizations and myself unites all the expertise and infrastructure required to reach the objectives of rnatop
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elucidating inner cells contribution to pavement cell shape acquisition in arabidopsis
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in plants the outermost epidermal cell layer is critical for protecting the entire plant against external threats such as rain wind and pathogens the plant epidermis is a complex tissue consisting of multiple cell types all with different shapes functions and developmental trajectories although studied in isolation our understanding of how these cells interact to ensure tissue integrity is poor but at present the outermost jigsawpuzzleshaped pavement cells have emerged as key players recent findings in the host lab suggest that the diverse physical andor mechanochemical nature of the cell wall is crucial for pavement cellshape acquisition and thus under influence of the underlying tissue layers however yet the identity of the putative signals derived from inner cell layers defining the shape of epidermal cells and the integrity of the multilayered leaf tissue remains to be explored hence in icon i will join the robert host lab to disentangle the signaling networks and mechanical constraints of inner mesophyll cells that determine epidermal pavement cell shape and organogenesis of the leaf using a suite of novel and multidisciplinary approaches in the model plant arabidopsis thaliana specifically i will acquire new skills in cuttingedge microscopy cell biology and biomechanics to generate a highresolution 3d map and uncover mechanicalphysical cues and leverage my expertise in transcriptomics genetics and molecular biology to determine molecular components together allowing me to decipher the overall mechanism via which mesophyll cells orchestrate pavement cell shape acquisition besides contributing new knowledge icon will allow me to expand my scientific expertise and gain key transferrable skills boosting my strive to become a research leader ultimately knowledge on how plants maintain tissue integrity can support the development of stressresilient plants and thus contribute to a sustainable agriculture in a changing climate
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violence work creating and contesting colonial authority on the ground in africa through everyday violence
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violence work is a groundbreaking study of everyday violence in belgian central africaburundi congo and rwanda 19th20th c though colonial violence has been studied widely few have explored how everyday violence enabled colonialism and allowed it to persist this project combines hitherto neglected source materials and a novel conceptual entry pointviolence workersto foreground the everyday violent practices crucial to creating and maintaining the colonial state the projects core claim and main innovation is that violence work was not performed exclusively by formal violence workersthe men in uniformbut rather by a range of actors colonizer and colonized in and outside the state everyday violence work includes not only direct acts of physical violence eg whipping but also other forms of punishment such as incarceration and coercion through the threat of violence as well as subtler forms of aggression forcing compliance eg harassment and the ways these different levels of violence reinforced each other this inclusive definition enables an unprecedented comprehensive view of the enforcement practices that colonial rule depended on violence work opens up new questions about the centrality of violence in theorizing creating and maintaining colonialism and the colonial state this first indepth multisited transnationalregional comparative study of everyday colonial violence will undergird further research on how colonial legacies persist and interact with local and new repertoires of violence work contributing to dismantling persistent colonial myths about these regions and their inhabitants as inherently violent the online database will be a crucial tool for future researchers and open up many new avenues of research its major innovation of a pluralistic approach to everyday violence work will reinvigorate the debate not only about colonial violence but also ultimately about colonial states and nationstates more broadly
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explorations in polar question meaning and its variation
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this project addresses polar question meaning and its variation by documenting and analyzing nuanced polar question meanings and their expressions across languages under current models of polar question meaning meaning nuances across languages are heavily undergenerated and certain effects such as negative polarity licensing and forms of bias remain elusive we use the idea of the duality of primary polar question meanings introduced in the applicants recent work as a departure point which defends a separation between polar and other propositional alternatives this view makes correct predictions in the treatment of existing problems and generates hypotheses as to the limits and structural correlates of variation the project will generate a crosslinguistically viable semantic model of polar question meaning and a framework of its variation based on a sizeable empirical contribution detailing polar question usage profiles from a diverse set of languages elicited with a stateoftheart twin questionnaire the project combines advanced insights and techniques from the semantics and pragmatics of questions semantic variation and linguistic documentation and is particularly timely in the context of the applicants recent work the applicant and the host possess crucial complementary skills in addressing these issues the applicant is an expert in syntax intonation and linguistic variation the entire host institute and in particular the supervisors are worldrenowned for their work on semantics and pragmatics with a strong focus on questions their collaboration will thus create a unique opportunity to thoroughly reanalyze a central topic from multiple theoretical and empirical angles while furnishing the applicant with skills in semantics pragmatics and advanced empirical methods with which she intends to launch further crossmodular linguistic variation projects and position herself as a leader in this domain of research
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inhibitormediated programming of glycoforms
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sitedirected mutagenesis revolutionised the study of proteins and enabled the development of proteinbased therapeutics our longterm vision is to have equivalent impact through the precise manipulation of the glycans carbohydrates on cells and recombinant proteins that will enable the discovery and production of the next generation of therapies for cancer neurodegeneration and other disease families the glycans that are present on most proteins and cells have a substantial impact on their biological functions yet the untemplated nature of their synthesis leads to inherent heterogeneity in both their structure and activity this heterogeneity is very difficult to control making it impossible to generate defined glycan ensembles with optimal activity using current technology here we present a radically new approach to the controlled manipulation of glycans that will be the functional equivalent of sitedirected mutagenesis for manipulating proteins we will use the delivery of computationally defined mixtures of enzymespecific inhibitors to the site of glycan biosynthesis in the cell to tune the activity of glycosyltransferases our approach termed inhibitormediated programming of glycoforms improglyco will provide an effective strategy to manipulate the glycosylation machinery and thereby generate proteins with defined ensembles of glycans it will enable the production of precision glycan engineered therapeutic proteins and vaccines moreover shaping cellular glycan profiles will aid discovery science to uncover glycan functions and improve therapeutic cells such as those used in chimeric antigen receptors cell therapy cart our technology will be adaptable and expandable into other cell types and organisms allowing glycan shaping in all areas of eukaryotic cell biology to enable new biotechnological applications and fundamental studies of biology
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advanced cleantech studies for the enhancement of the research and innovation capacity of the plovdiv agricultural university au element
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the element project at the plovdiv agricultural university bulgaria represents a notable advance in cleantech and biomass resource efficiency key to this initiative is the appointment of an era chair which will bring significant expertise in applied sciences the core objective of the project is to stimulate both basic and applied research with a focus on broadening and enriching the knowledge base in these specific areas in order to achieve these goals element will establish a new centre of excellence in cleantech and biomass resource efficiency this centre is expected to optimise the use of existing scientific capabilities improve the efficiency of innovation generation and application and facilitate increased multinational cooperation through these efforts the project aims to make a substantial contribution to the field and enhance bulgarias scientific standing in cleantech and biomass resources
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engineered heart tissue eht devices based on ion conductive guanosinequadruplex gq hydrogels a route to advance in vitro 3d cardiac tissue models
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in this project a microengineered heart tissue eht device that will advance the physiological relevance of current in vitro 3d cardiac tissue models will be developed in moving towards this goal this project will synthesize conductive guanosinequadruplex gq hydrogels and implement them as cell scaffolds in eht devices key aspects of biomaterials design are the unique conductive and hierarchical 3d fibrous network and the good biocompatibility of gq hydrogels which will support cardiac cell culture upon integration in the eht platform the mentioned properties of gq hydrogels will enable electrical stimulation of embedded cardiac cells under mild pacing voltages thereby promoting the formation of morphologically and functionally mature cardiac tissue gq hydrogels will demonstrate high flexibility and potentially broad utility as a biocompatible and conductive biomaterial for in vitro cell experimentation the outcomes of this project will expand the horizon of preclinical 3d cardiac tissue models paving the way for future approaches to drug testing and personalized cardiovascular medicine
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towards primatelike artificial neural networks for visual object tracking
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the prinnevot project embarks on a mission to bridge the gap between computer vision and the primate visual system in the context of visual object tracking vot vot is the task of maintaining focus the prinnevot project embarks on a mission to bridge the gap between computer vision and the primate visual system in the context of visual object tracking vot vot is the task of maintaining focus on a specific object amidst a dynamic visual environment our brains excel at it but replicating this ability in artificial vision systems remains a challenge this project seeks to develop a novel class of vot algorithms inspired by the primate visual systems prowess despite notable advancements in deep learningbased vot over the past decade these algorithms still fall short in emulating the robustness exhibited by primate vision prinnevot will address this gap through a multifaceted approach firstly prinnevot will construct a comprehensive reference dataset investigating both primate behavior and neural recordings secondly among the existing artificial neural network annbased vot methodologies the project aims to identify those that align most closely with the primate brains mechanisms lastly prinnevot will leverage the discovered inductive biases to develop a new ann architecture for vot that closely mirrors the primates way of continuous object recognition and localization by merging computer vision and computational neuroscience research prinnevot aspires to contribute to the development of more accurate and robust vot algorithms these algorithms in alignment with the european unions pursuit of safer and ethically grounded artificial intelligence promise to enhance humancentric and trustworthy technologies furthermore the projects outcomes will not only benefit ai and computer vision but also advance our understanding of the primate visual system offering new empirical models of how the brain tracks objects in dynamic visual environments
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the paradox of political marginalisation young people and political power
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political marginalisation understood as the systematic underrepresentation of social groups in political office constitutes a major democratic problem by betraying the ideal of equal voice it biases political decision making challenges democratic legitimacy and ultimately risks creating political alienation and discontent yet we fail to understand the persistence of the problem because extant research has not probed the underlying norms that exist in a society about what political power is who can hold it and how it can be exercised thus while we know that members of underrepresented groups do not reach out for power to the same extent as others we do not have a theory that can explain why the voices missing from politics seem to exclude themselves while those already represented speak with great fervouryopow breaks new ground in the study of political marginalisation by locating its roots in societal norms about political power that make a lasting imprint already early in life the theoretical framework explains how societal norms affect young people through the messages they receive and internalise and the unequal experiences they have with political power methodologically pioneering the project combines machinelearning techniques and indepth interpretations to detect how societal norms pattern the meaning of political power across societies and social groups empirically yopow generates the firstofitskind database of messages about political power directed at young people insights into their beliefs about power expressed in their own words and novel data on youths early experiences with political power in political youth organisations this project will significantly improve our understanding of one of the most serious and persistent challenges for democracies of today and the future by exposing the societal norms that give rise to biased beliefs and eventually shape who is seen as fit for power among societys youngest members
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valorisation and optimization of novel firstin class succinatedepleting therapies
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succipro is a spinoff company from pere virgili health institute and rovira virgili university it is an earlystage drug development company focused on therapies able to modulate the succinatesucnr1 pathway which have strong potential on many inflammatory and metabolic disorders currently the company is developing suczyme a novel firstinclass oral enzyme therapy able to deplete succinate that has crohns disease as a first indication succipro will lead the development until the end of clinical phase 2a when the asset will be licensed to a bigger pharma companycurrent proposal aims to conduct critical technical and business activities with the overall goal of raising a first seed investment round from a technological perspective during the project the team will advance in the development of the enzyme therapy by partnering with an innovative company expert in enzyme engineering able to improve our candidates in terms of specificity activity and stability later we will conduct in vitro and in vivo efficacy studies that will enable the designation of final lead candidate in parallel to the technical development and in order to have more a more accurate vision about the european market we aim to perform early price reimbursement and market studies in europe we will also participate in the activities organised by investeu and the enterprise europe network and we will introduce our company into the us startup ecosystem to expand companys innovation network and look for investment in the us overall the project will contribute to increase the trl level of our asset improve our competitiveness and visibility within the international biotech sector and support us in the raising of a seed investment round
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expanding a prospective clinical trial examining the immune response of participants receiving modified vaccinia ankara vaccine to africa
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the current mpox outbreak affecting the democratic republic of the congo ongoing since 2023 has resulted in more than 19000 causes and over 1000 deaths with women accounting for more than half of those affected the previous global mpox outbreak in 2022 was alleviated in part with use of preventive vaccination using modified vaccina ankara mva vaccine however whether this vaccine induces sufficient immune responses in women and those with immunosuppression which is common in affected areas and how long vaccineinduced immunity lasts is not well defined furthermore outbreak responses within africa are also limited by lack of robust diagnosticsthe mpox afrivac project will engage with key stakeholders and the community to address these knowledge gaps and capacity limitations by adapting a phase 4 clinical trial of preexposure vaccination against mpox currently underway in europe to african sites affected by the current outbreak this will be accompanied by technology transfer to develop mpox immune diagnostics and knowledge transfer to develop a regional vaccineefocused clinical trials unit together these activities will address key strategic priorities within the region address knowledge gaps and significantly contribute to regional capacity and public health response to bring an end to the mpox outbreak
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root2resilience root phenotyping and genetic improvement for rotational crops resilient to environmental change
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root2res will deliver a package of solutions to enhance the resilience of rotational cropping system by considering relevant root traits with respect to the impact of climate change innovations will include phenotyping genetic and modelling tools that will help breeders evaluate in field and controlled conditions novel and existing genotypes of a range of crops cereals potatoes legumes as root ideotypes for different soil and climatic environments across europe root2res will also investigate the potential role of emerging crops sweet potato lentil to enhance resilience to environmental change by assessing their genotypic and phenotypic variation the environments targeted include those predicted to suffer from the largest impact of climate change on yield in europe resilience to stress will focus on greater variation in water availability both drought and waterlogging and interactions with other stresses temperature reduced nutrient availability we will also consider the impact of novel understanding of the plasticity of traits to stress traits to be assessed will focus on exploration exploitation and rhizosphere microbiome related traits integrated in an extended phenotype the impacts of the more resilient ideotypes designed in root2res on the delivery of climate change mitigation outcomes soil carbon sequestration nutrient utilisation and greenhouse gas emission will be assessed in field root2res will integrate a strong interaction with stakeholders all through the project particularly breeders and farmers the ambition of root2res is to deliver crops adapted to changing environments and able to mitigate climate change by utilising existing genetic diversity for breeding programs in a range of crop species essential to cropping systems and then widening understanding to crops suitable for resilient future systems this ambition will be supported by the joined commitment of a multidisciplinary partnerships across europe and beyond
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highquality laserdriven proton beams for multidisciplinary applications
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proton accelerators are in significant demand due to their widespread societal applications for instance clinical cancer therapy as the protons target deepseated tumours with negligible damage to the surrounding healthy tissues high capital and operational costs associated with the conventional accelerators make proton therapy poorly accessible which has triggered interest in search for affordable alternatives in this context proton acceleration employing high power lasers has recently emerged as a promising alternative to the conventional techniques in addition to their compactness and cost effectiveness the laserdriven sources deliver high doses in an extremely shorttime period one billionth of the second offering a unique prospect for radiobiological studies the key challenge however is to overcome broad energy spread and large divergence of the laserdriven proton beams this project aims to control these shortcomings by employing a novel target arrangement at pw class laser which can effectively tailor the spatial and spectral profile of the beam at the source importantly at high repetition rate 1 hz transporting the beams to large distances away from the laser interaction region will be demonstrated by using a system of magnets as a step towards building dedicated beamlines for multidisciplinary applications the highquality proton beams with energies required for therapeutic applications 50mev will be deployed for the first time in invitro radiobiological studies on cancer breast cells at dose rate of 100 gymin the timeliness of the project is underpinned by the ongoing developments of highpower laser facilities globally eg the pillars of the paneuropean extreme light infrastructure epac uk and zeus usa notably this cutting edge research would reinforce europes leading role in the development of alloptical accelerators and and position me at the forefront of this emerging field
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fluency as faithfulness a cognitive approach to an interpreting megacorpus
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professional interpreters provide the highest quality and most instantaneous type of multilingual communication across interpreting in spoken and signed languages users evoke the notion of fluencyasfidelity when they engage with and evaluate interpreters this notion is also applied to language learners and politicians this implies that fluency taps into a universal cognitiveevaluative mechanism that provides information about the speaker in communicative contexts recent research on fluency has explored small corpora of interpreting and shown the value of the usagebased theory in connecting the social and cognitive underpinnings of fluency however prior studies fail to represent the multimodal context of interpreting and remain removed from end users the intersectional embedding of this notion and the process of explicating meanings in creating fluency often go unnoticed the project fluency as faithfulness a cognitive approach to an interpreting megacorpus faith investigates the role of fluency in the production and perception of faithfulness the objective will be to explain how interpreters create unfaithfulness using cognitive abilities such as chunking and construal it will do so by unifying existing interpreting corpora comparing the production and perception of fluency in political interpreting and empirically demonstrating the cognitive basis of explicitations in interpreting faith will contribute the first multimodal intermodal and openaccess interpreting corpus and implement for the first time multimodality and intersectionality in corpusbased interpreting studies it will provide answers to longstanding questions concerning the nature of the faithfulness norm the explicitation universal and language forms in interpreting cumulatively faith will further the eu priority of promoting european interests and values on the global stage by enabling intercultural understanding between policymakers and diverse groups
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development of a sustainable lowcost and longterm labonachip colorimetric paperbased sensor for saxotoxin quantification in water and seafood
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dr sara santiago malagn will conduct a fellowship focused on developing a labonachip loc colorimetric paperbased device for pointofneed pon detection of saxitoxin a toxin produced by cyanobacteria and certain microalgae the primary objective of this project is to mitigate cyanobacteria contamination in stagnant water and harmful algae bloom hab occurrences in seawater which can lead to the death of marine species and the poisoning of animals and humans we aim to validate an accessible ecofriendly costeffective and userfriendly technology that can be extended to detect and quantify various biotoxins relevant to public health and the environment the driving force behind this project is the current gap in the development of portable sensor systems for environmental applications in marine ecosystems freshwater and seafood quality control all without the need for specialized equipmentin addition to the research that will help control and prevent damage to the ecosystem and preserve species diversity the methodology and materials presented are sustainable and environmentally friendly aligning with the projects environmental commitment furthermore the materials used silk will facilitate the stabilization of biomacromolecules required for the detection and quantification of saxitoxin enabling the creation of longspan sensors ultimately the end goal is to validate that the colorimetric device designed as a toolless system can be operated by minimally trained volunteers end users through a userfriendly mobile application interface even if they do not possess specialized knowledge or skills these individuals play a crucial role in environmental preservation and prevention effortsthis grant would offer the applicant the opportunity to lead an international project fostering collaborations with esteemed institutions and researchers for future global initiatives
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new sustainable ferich magnet using a predictive alloy and microstructure design toolbox
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ndfeb magnets are central to both green mobility and the generation of electricity from renewable resources but the need to incorporate heavy rare earths like tb and dy highly critical raw materials to operate these magnets above 100 c required for electric vehicles and wind turbines makes them very costly environmentally damaging and with a very fragile value chain and despite four decades of effort no practical alternative to ndfeb has been found smfe12based compounds have superior intrinsic magnetic properties actually surpassing those of benchmark ndfeb and without the need for additional heavy rare earths the challenge with smfe12 is phase instability in the bulk form and creating a microstructure that will convert the large intrinsic anisotropy field into a usable coercivity what we know so far is that the solution lies in combining multiple alloying elements each one impacting differently in smfemxz12 for example 20 alloying elements results in around 108 combinations experiments if each element varies from 1 to 15 at in quinary compositions magtool will create a cuttingedge toolbox that combines experimental techniques with stateoftheart machinelearning algorithms eliminating the need for trialanderror this breakthrough approach drastically reduces the number of experiments from a daunting 108 down to a manageable 102 magtool will achieve that by breaking the multielement complexity starting to predict the compounds with useful phases using only three elements this knowledge will be transferred to multielement situations and combined with robust experiments to deliver superior magnetic properties in powders and meltspun ribbons magtool will also include a laserdeposition additivemanufacturing system for rapidly creating many compositions within the same bulk samples through compositional gradients the outcome of the project will be the new medium and highperformance sustainable magnet
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2d heterostructure nonvolatile spin memory technology
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in modern society as the use of information technology is rapidly increasing it is necessary to develop new nonvolatile faster and energyefficient electronics spintronic technologies open promising routes to achieve this however devices based on conventional materials are still too inefficient for applications in consumer electronics here we propose to develop a new energyefficient spintronic memory device platform based on emerging atomicallythin twodimensional 2d quantum materials for the next generation of memory technologies the 2d topological spinorbit materials can generate a giant currentinduced spin polarization whereas room temperature 2d magnets provide the prospective of electric control of magnetism the proposed van der waals heterostructure spintronic devices consisting of 2d topological spinorbit materials and 2d magnets will enable exceptionally efficient spinorbit torque sot functionality with low current densities and ultrafast magnetization switching speedall2d multifunctional sot will provide a strong synergy between spintronics and 2d material and take this research from trl2 to 4 we will employ novel methods to control their sot properties by the twist angle between the layers topological aspects crystal symmetries proximity interaction and strong electric field effects to achieve this challenging goal this project bringstogether pioneering and worldleading experimental and theoretical researchers and a company in the field of spintronics and 2d materials in europe the ultimate demonstration of all2d sot device units will merge the field of spintronics and twistronics allowing for physical and electrical tuning parameters to achieve enhanced control over the device functionalities these developments will enable groundbreaking 2d sot technologies for lowpower nonvolatile ultrafast and scalable data storage and processing devices and possibly new spinbased computing paradigms and architectures
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explainable and robust automatic fact checking
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explainyourself proposes to study explainable automatic fact checking the task of automatically predicting the veracity of textual claims using machine learning ml methods while also producing explanations about how the model arrived at the prediction automatic fact checking methods often use opaque deep neural network models whose inner workings cannot easily be explained especially for complex tasks such as automatic fact checking this hinders greater adoption as it is unclear to users when the models predictions can be trusted existing explainable ml methods partly overcome this by reducing the task of explanation generation to highlighting the right rationale while a good first step this does not fully explain how a ml model arrived at a prediction for knowledge intensive natural language understanding nlu tasks such as fact checking a ml model needs to learn complex relationships between the claim multiple evidence documents and common sense knowledge in addition to retrieving the right evidence there is currently no explainability method that aims to illuminate this highly complex process in addition existing approaches are unable to produce diverse explanations geared towards users with different information needsexplainyourself radically departs from existing work in proposing methods for explainable fact checking that more accurately reflect how fact checking models make decisions and are useful to diverse groups of end users it is expected that these innovations will apply to explanation generation for other knowledgeintensive nlu tasks such as question answering or entity linking to achieve this explainyourself builds on my pioneering work on explainable fact checking as well as my interdisciplinary expertise
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deciphering subsurface carbon fixation
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despite containing the vast majority of carbon on the planet the earths subsurface represents a mostly uncharacterized frontier for biogeochemistry and microbial ecology while carbon fixation at the earths surface has been drawing a lot of attention for decades subsurface carbon fixation remains poorly understood yet metabolically it engages a rich diversity of non canonical pathways contrasting to surface carbon fixation dominated by the canonical calvin cycle also its contribution to the global carbon cycle though long overlooked is now garnering increased attention in recent years several studies aiming to characterise the diversity of carbonfixing organisms within the subsurface have emerged however these studies are isolated and do not accurately describe the dependence of these metabolisms on the geoenvironmental context i propose here to provide a blueprint of subsurface carbon fixation on earth in a topdown approach i will systematically sample various subsurface environments for metagenomic and metaproteomic analysis of carbon fixing metabolisms in search of the main environmental factors determining the carbon fixation strategy used in parallel to this i will undertake a bottomup experimental approach to explore and confirm this metabolic versatility in response to changing environments through controlled culturing experiments finally i will integrate the acquired results with stable isotope analysis to build a metabolic model aiming to comprehensively predict carbon fixation fluxes in function of the geoenvironmental context the proposed holistic approach will increase our understanding of the role of subsurface microbial metabolisms in global carbon cycling
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deep reinforcement learningbased battery management system for electric vehicles
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battery management system bms plays a pivotal role in monitoring control and protecting the electric vehicle ev lithiumion battery packs in vehicular applications batteries are usually subjected to harsh operating cycles and varying environmental conditions leading to very complicated interactions of different aging factors and unforeseeable modeling uncertainties therefore the classical modelbased techniques cannot completely handle the foregoing factors which always leave an unwanted state estimation error in the bms this project intends to apply a multidisciplinary approach by combining the advantages of deep reinforcement learning and classical modelbased techniques to improve the bms functionality in evs specifically deepbms aims to 1develop efficient deep reinforcement learningbased algorithms which are able to capture the convoluted timevarying behavior of battery and can gradually improve themselves by learning in realtime 2 combine the beneficial features of modelbased and datadriven techniques to improve the state estimation accuracy in a wide temperature range and over the full life span of the batteries thereby increasing the reliability and extending the battery lifetime the interdisciplinary nature of deepbms is very strong involving a combination of control and state estimation theory power electronics battery storage systems and machine learning the supervisor and candidate have excellent complemental research experiences in these fields providing the necessary competencies to bring the project to successful completion the project ensures twoway transfer of knowledge including training of the candidate in cuttingedge advanced techniques in a stateoftheart laboratory which improves his future career prospects likewise deepbms is in line with the eu strategic action plan on batteries and its results have a great potential to be further developed at the fundamental and applied levels through followup research
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protocells in the archaean rock record implications for the origin of life and detection of biosignatures
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fossilised remains of protocells transitioning towards the first living organisms may be observable in the early rock record distorting our interpretation of biosignatures protocells cellular structures existing prior to the emergence of life would have comprised simple membranes and molecular machinery the formation of complex protocells is poorly understood the interpretation of fossilised microorganisms in the early rock record is steeped in controversy the potential for abiotic microstructures to further complicate this interpretation has long been recognised but has not been systematically tested evidence suggests that prebiotic structures are very difficult to distinguish from microfossils however little is known about the chemical and physical characteristics of these biomorphs that may enable us to tell the difference this project will use a novel microfluidic approach to expand the experimental scope for formation of protocells of increasing complexity resulting microstructures will undergo silicification and diagenesis the principal preservation pathway for early archean microfossils stateoftheart analytical techniques will be used to characterise biomorphs providing the first rigorous investigation of the feasibility of protocell preservation and how this might express in the geological record these data combined with a predictive model and biological controls will allow for identification of key observables that will act as biogenicity indicators purported microfossils will then be examined and reinterpreted using the novel biosignatures this project has the capacity to represent a paradigm shift in our fundamental understanding of the origin and evolution of life on earth and possibly elsewhere in the solar system collectively this will represent a major advance in our understanding of the geological record providing the first comprehensive methodology to distinguish between abiotic prebiotic and biological microstructures
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deep learning the dark universe with gravitational waves
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gravitational wave astronomy has opened an extraordinary new window to test the theory of gravity in the genuinely strong highly dynamical and relativistic regime the ligovirgo collaboration has now detected over 50 mergers of compact binary systems and this number will considerably increase in the coming years there are currently two main issues related to the possibility of testing gravity with gravitational wave observations the weakness of parametric tests of general relativity to go beyond null tests and the very long inference time required by standard samplers which can take up to months specific waveform models and new techniques to speed up statistical inference are therefore crucial to maximise the scientific return of already available and upcoming data in this project we will construct an analytical model of the gravitational waves emitted during the late inspiral and merger of compact objects in theories of gravity that are cosmologically motivated namely that have a chance to explain dark energy we will then leverage deep learning techniques to promptly produce the posterior for the corresponding parameters given the detector data to this aim we will build up on two codes developed by one of the supervisors roman and percival which pioneered the use of machine learning in gravitational wave science we will then apply this new pipeline to the real ligovirgo data and perform bayesian inference of dark energy parameters all together this project will provide a new and complete framework to test the dark universe with gravitational wave observations exploiting stateoftheart deep learning techniques
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macroscopic properties of interacting bosons a unified approach to the thermodynamic challenge
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interacting bosons are unique quantum systems whose low temperature phases exhibit fascinating quantum mechanics effects at a macroscopic scale in the past two decades the mathematical understanding of these systems improved tremendously however their behavior in the thermodynamic limit is still poorly understood although this is the appropriate large scale limit to prove the emergence of scaling laws and universality as well as to investigate the occurrence of phase transitions match aims at investigating the low energy properties of interacting bosons in the thermodynamic limit and at gaining a mathematical understanding of the emergence of correlated phases in the form of boseeinstein condensation and quasilong range order as well as of their instabilities due to thermal fluctuations or threebody recombination effects of efimov type our plan is to exploit scaling limits as a framework to identify and overcome one at a time the mathematical obstructions that currently prevent us to control the system at finite density in the thermodynamic limit in order to make progress on this program match will introduce novel mathematical methods inspired by renormalization group approaches and grounded in the second quantization techniques developed by the pi and collaborators valid on an increasing sequence of scalesultimately the research led by match will lay the foundation for the rigorous description of several phenomena which are at the frontiers of present theoretical and experimental research where collective excitations of quantum systems are described in terms of emergent bose gases such as in the bcs theory for superconductivity the molecular description of strongly interacting fermi gases and the spinwave theory for quantum magnetism
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identification of longterm therapeutic strategy in igemediated allergy by leveraging humanized models and patient samples
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ige is a key driver of allergic diseases which affect approximately onethird of the worlds population monoclonal antibodies mabs targeting ige are approved for the treatment of allergic asthma and show clinical benefit in a number of other allergic diseases yet a sizable portion of patients do not respond to the drug despite high levels of ige there is a clear need to better define which allergy features depend or not on ige and to find predictive biomarkers in order to identify patients who will benefit from antiige therapy in addition use of antiige mabs is limited by very high cost and the need to perform frequent reinfusion to maintain clinical efficiency combining unique mouse models humanized for ige and its two receptors fceri and cd23 clinical samples from patients undergoing fdaapproved antiige therapy and a novel highthroughput ige repertoire analysis method the project addresses three key questions 1 which ige features distinguish responders vs nonresponders to antiige therapy and can it be used as predictive biomarker 2 which key allergy features depend on ige and through which mechanisms 3 can we induce longterm protection against igemediated allergies with a vaccine approach this translational project will increase our understanding of the basic mechanisms underlying allergic diseases and has the potential to identify important new therapeutic strategies
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commercial maturation of medicquant
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medicquant is an in vitro diagnostic company where we have invented a deeptech platform technology that will revolutionize small molecule diagnostics our first product doaquant focuses on improving stroke management in the event of stroke rapid treatment is vital for survival and every minute matters it is crucial to determine the level of anticoagulant ac drugs in these patients as this determines which lifesaving treatment can be given current diagnostic solutions take more than 40 minutes thus risking patients lives doaquant can rapidly provide clinicians with the answer they need to determine the correct lifesaving management in stroke thus greatly reducing delay in treatment mortality and disability dr line debois is ceo and cofounder of medicquant and has through her academic career researched biosensors concluding in the coinvention of the technology behind medicquant she has taken the position of ceo in medicquant since incorporation with the vision to lead the company to success and make a difference in the healthcare system the overall goal with the activities performed during the women techeu program is commercial maturation of medicquant and preparing for vc fundraising this will be achieved through specific tasks and by further developing ceo lines commercial and leadership skills the specific activities to achieve this is making a market access strategy through reimbursement analysis regulatory strategy pricing strategy and willingness to buy preparation of documentation portfolio for investment and further developing commercial skills through the mentoring program that are needed for vc fundraise and manage a company in growth this program will directly help overcoming the most crucial commercial challenges that both medicquant and line as ceo are currently facing thereby enabling medicquant to become a female lead success empowering women in deeptech and fostering further diversity in the lifescience sector
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cellinstructive matrices to deconstruct tumour tissues
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this research addresses a clinical problem with an innovative approach pancreatic cancer is one of the deadliest cancers and only 10 of patients survive 5 years after diagnosis to find better therapies we need patientspecific models that mimic the biology of tumour tissues and target interactions between different cell types we will develop a controllable platform for modelling the human disease in the laboratory we will use our new platform to discover better ways of treating the disease
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improved soilcable interaction mooring simulations
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moorings of floating oil and gas og structures exhibit surprisingly large failure rates in the og industry this problem is simply handled by redundancy in the design it is unlikely that marine renewables in order to obtain a competitive levelised cost of energy lcoe can afford such redundancy in the mooring design islington has the overall objective to reduce uncertainties in estimated fatigue damage of mooring cables due to soilcable interaction in the touch down zone tdz and subsequently lower the economic cost of mooring systems for marine renewables to achieve this objective the following research actions will be carried out 1 improving the numerical modelling of the cablesoil interaction in the tdz for mooring cables by allowing for timedependent granular soil dynamics this will be done by creating an application programming interface api inside a granular particle soil solver to allow a twoway coupling to a mooring cable solver providing position and motion of the mooring cable 2 generating experimental data for mooring line trenching to be used for validation this will be done by forced oscillations of a cable in a wave flume with sandy bottom and log the development of the trenching under different forcing 3 numerical investigation of the effect of trenching on fatigue of mooring cables this will be done for standard test cases such as the iae task 30 oc3oc6 test cases the work proposed is well beyond stateofart with respect to ground modelling of mooring cables in that the bathymetry will be timedependent so trenching will be modelled together with the nonlinear cable response the work on trenching effect to mooring line fatigue and snap load generation and dissipation will be the first such investigation the resulting papers models and experimental datasets will be released openaccess in line with the open science practice
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precision studies with optically pumped beams of exotic nuclei
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neutrons are fascinating particles and are important for nuclear structure tests of the standard model of particle physics or properties of neutron stars unfortunately they are electrically neutral so learning about their distribution in nuclei especially far from stability is difficult however they possess a magnetic moment which contributes to and sometimes dominates the distribution of nuclear magnetization this project aims to address the challenging question of the distribution of magnetisation and neutrons in unstable nuclei i will use a novel highaccuracy experimental approach combining radiationdetected nuclear magnetic resonance with rflaser double spectroscopy on opticallypumped shortlived nuclei the project builds on recent achievements in my team allowing to determine magnetic moments of unstable nuclei up to ppm accuracy i will combine this approach with accurate measurements of the hyperfine structure using the laserrf doubleresonance the signals will be detected efficiently using decay anisotropy thanks to spin polarisation via optical pumping this will lead to an accurate determination of a hyperfine anomaly a small effect on atomic hyperfine structure due to the distribution of nuclear magnetisation a close collaboration with atomic and nuclear theorists will allow to determine the magnetisation and neutron distribution in many nuclei light neutronhalo 11be proposed halos in neutronrich ne na mg k and ca nuclei and heavy rn fr and ra isotopes interesting for studies of atomic parity violation apv and electric dipole moments the project will take place at the isolde facility at cern i will also work closely with quantumchemistry atomic and nuclearphysics theorists who will use our data to improve their approaches this will open new perspectives for nuclear structure studies determination of neutronstar properties or apv studies it will also allow test of atomic and nuclear calculations
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assembly lines in circulation smart digital tools for the sustainable humancentric and resilient use of production resources
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a large part of production assets such as robotic arms conveyor belts do not reach their maximal lifetime and become prematurely obsolescent anecdotal evidence from the automotive industry suggests that 60 to 70 of production resources is prematurely taken out of operation scrapped or at best sold for spare partsthe aim of alicia is to create and demonstrate a circular manufacturing ecosystem cme for production resources such as robotic arms or conveyor belts the underlaying vision is that within five to ten years production resources will be traded and reused to their maximum utility inbetween factories in europe ultimately contributing to closing the loop of production assets as circular economy subjectsthe project aim will be achieved by integrating and demonstrating in two real industrial environments at continental and comau a combination of innovative and symbiotic digital tools as key enabling technologies behind the alicia cme ultimately enabling to design deploy run decommission and recirculate secondhand production lines 40 faster reduce material consumption by up to 80 and reuse up to 100 of the assets the innovations behind alicia include a machinereadable ontology for mapping factory owner requirements an aimatchmaking engine for combining incumbent factory assets with secondhand assets coming from the alicia online marketplace a plug produce middleware for seamlessly connecting the production assets and a digital shadowdigital twin to rampup and operate the alicia secondhand line novel circularityasaservice business models will be evaluatedalicia addresses the eu machinery and equipment as well as machinery repair service market segments which together contributed 288 billion eur in value added to the eu economy in 2018 alicia is expected to contribute to increasing the eus resilience against disruptions in global supply chains and significantly contribute to the creation of a circular economy
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the musical avantgarde in rome in the 1960s actors and networks in music history
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romavantgarde aims to reveal a particular phenomenon in the history of music the effervescence of avantgarde networks in rome during the 1960s this phenomenon saw the first steps of influential figures to come frederic rzewski alvin curran and ennio morricone but it is also of particular interest as it involved a large number of artists from varied national and cultural horizons connected diverse institutions schools bars religious establishments and saw the encounter of various genres art music jazz and popular music to create original repertoires as a consequence this is an ideal case to show how art music creationdespite the enduring paradigm of the individual geniusis a collective phenomenon involving human but also nonhuman actors institutions artifacts ideas to do so romavantgarde will draw specifically on actornetwork theory ant but also on social network analysis sna through this case study romavantgarde aims to advance knowledge on the history of twentiethcentury music and to reveal rome as a cosmopolitan city actively participating in the construction of the european musical landscape at the same time it aims to further research on creativity and to encourage the recent exchanges between network theories and music studies this project will be undertaken in sapienza university of rome a reputed university for research in the history of music sapienza is also the ideal institution to carry out research in the citys libraries and archives and to carry out the collection of testimonies before witnesses disappear professor emanuele senici an internationally renowned music historian with extensive experience in the history of modern and roman music will supervise this project this experience is thus expected to have a profound impact on my training scientific maturity and reputation and to place me in good stead to qualify for a tenuretrack position in europe
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scaling democratic innovations
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scaledem aims at unlocking the uptake of democratic innovations born in ri actions in particular stemming from eufunded projects this is achieved by developing a scaling infrastructure including policy roadmaps and an actionable compass for scaling democratic innovations based on a grounded theory of scaling scaledem helps researchers practitioners and policymakers assess opportunities and barriers for scaling democratic innovations along four dimensions scaling high impacting laws and policy out impacting greater more and new people deep impacting cultures and identities and in impacting processes quality scaledem starts by analysing innovative solutions developed in ri projects on the issue of citizen participation and engagement in democratic governance in particular horizon projects whose end date is after january 2023 to develop a theory of scaling following a collaborative and interdisciplinary translation process in its translation hub scaledem deploys two ambitious scaling grounds in the forms of twinning and pilot programmes the scaling grounds test and encourage the uptake of democratic innovations by new end users scaling the societal impact of those solutions further scaledem establishes iterative feedback and capacitybuilding mechanisms to support the replicability and adaptability of solutions in new operational environments and actionability of theoretical solutions in parallel scaledem involves and nurtures a global community of end users it leverages strategic partnerships with relevant ri projects initiatives and networks notably the network for innovative solutions for the future of democracy to overcome the fragmentation of knowledge identify opportunities to increase synergies for capacitybuilding actions to policymakers practitioners and researchers and expand the societal and political impact of eufunded research in the eu and countries from global europe
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targeting b cell activation driven by natural killer cells
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autoimmune diseases affect nearly 4 of the worlds population and can be lifethreatening among them primary sjögren syndrome pss is the most common systemic autoimmune disease unfortunately to date treatments are focusing on relieving symptoms it is of public relevance to find potential new biomarkers for treatments b cells are one key player in pss and promising drugs targeting b cell activation are currently under phase 3 clinical trials restraining b cell hyperactivity is central to treating pss permanently hence instead of targeting b cell activation pss treatments would also benefit from targeting signals or interactions leading to b cell activation the tabank project aims to address this hypothesis by using cuttingedge technologies highparameter flow cytometry singlecell sequencing technologies and unsupervised analysis to interrogate the immune network in the circulation of pss donors as well as in the inflamed environment of impaired salivary glands this overarching goal will be achieved by i compiling a comprehensive database of immune cell profiles in pss using both singlecell sequencing and highparameter mass and flow cytometry ii determining potential interactions of immune cells leading to b cell activation using a novel computational approach and iii validating these interactions using ex vivo culture tabank will be conducted at the lymphocytes b autoimmunity and immunotherapies center universit of brest occidentale a leading research institution in the study of immunotherapies for b cell diseases this project will be supervised by two leading experts in autoimmune diseases and b cell biology this unique synergy in addition the researchers own expertise in examining immune responses in human tissues particularly oral mucosal tissues will precondition the project for success while facilitating a mutually beneficial twoway transfer of knowledge
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highly efficient and sustainable refrigeration based on solid state magnetic cooling device
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cooling and refrigeration account for 78 of global greenhouse gas emissions and 20 of electricity demand the standard refrigerant fgases have a tremendous global warming potential gwp and are being phased out in the eu available alternative gases are either toxic or explosive posing serious issues for their applicabilitymagnotherm has developed the first industrially feasible refrigeration unit based on magnetic cooling technology that uses a specific class of material and alternating magnetic fields this is achieved thanks to a patented process to mass produce highly performant stable and cheap magnetocaloric materials using abundant noncritical materials and to interdisciplinary backgrounds and worldleading research resulting from tu darmstadtmagnetic cooling implements a solid state cooling cycle using no refrigeration gas with 0 associated gwp no risk to the environment and no issues of flammability it is x3 more efficient and achieves 40 electricity savings
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quantumenhanced freeelectron spectromicroscopy
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ultrafast electron microscopy relies on the spatial spectral and temporal manipulation of free electrons with nmmevfs precision to map the structural dynamics as well as the vibrational and electronic ground and excited states of nanomaterials with quefes i will introduce a conceptually disruptive approach to capitalize on the quantum nature of free electrons and their interactions with matter and radiation fields aiming to obtain previously inaccessible information on the atomicscale dynamics of such materials to reveal hidden properties of the quantum vacuum and to control the manybody state of quantum matteri will address five challenges of major scientific relevance i the spatiotemporal control over the density matrix of free electrons by interaction with suitably designed optical fields to overcome the current limits of spacetimeenergy resolution in timeresolved electron spectromicroscopy ii a disruptive approach to map the nanoscale quantum fluctuations and the outofequilibrium state associated with optical near fields in vacuum and polaritonic excitations in nanomaterials iii a fouriertransforminspired method to image the spatiotemporal evolution of atomic structures charge carriers and dynamical screening iv the use of free electrons to flexibly read and write the manybody quantum state of trapped rydberg atoms and quantum gases and v the realization of allelectron pumpprobe spectroscopy combined with the formation of dynamically screened multiple freeelectron bound states for lossless charge transport in a semiconductori will pursue these research frontiers by relying on the strong interdisciplinary theoretical background of my group at the intersection between electronlightmatter interactions and nanophotonics introducing a change of paradigm in the use of free electrons to break the current limits of spectromicroscopy and having the potential for revolutionizing our ability to image and manipulate the nanoworld
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asymmetric carbyne catalytic transfer to streamline synthesis of chiral amino carbonyls
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the chiral amino carbonyl is an important structural motif prevalent in natural products and therapeutic agents despite that many methodologies have been developed for their diastero and enantioselective synthesis most of these methods require multistep manipulations with prefunctionalized substrates that fail to introduce the amino carbonyl moiety at the latestage of complex molecule synthesis chiralbeta aims to develop an innovative technology to rapidly construct chiral amino carbonyl derivatives with feedstock and fine alkenes as well as with complex drug moleculesnatural products based on a rhcatalyzed asymmetric carbyne transfer platform a key strength of this conceptually new and multidisciplinary proposal is the introduction of a secondment phase in novartis basel to explore reallife applications the ambitious action merges perfectly the expertise of the host in novel ch and cc bond functionalization strategies based on the catalytic generation of carbyne equivalents with the strong background of the applicant in metalcatalyzed asymmetric reactions thus enhancing twoway transfer of knowledge between the er and the host group this project will expose the fellow to a wide range of cuttingedge chemistry and biomedical sciences in an interdisciplinary and international environment iciq novartis and enable the fellow to become a leader for the next generation in the field of chemical synthesis and latestage functionalization techniques
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technology for highrepetitionrate intense laser laboratories
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the thrill project deals with providing new schemes and devices for pushing forward the limits of research infrastructures ri of european relevance and esfri landmarks to do so the project partners have identified several technical bottlenecks in highenergy highrepetitionrate laser technology that prevent it from reaching the technical readiness level required to technically specify and build the needed devices and guaranteeing sustainable and reliable operation of such laser beamlines at the partnering ris advancing the technical readiness of these topics is strategically aligned with the longterm plans and evolution of the esfri landmarks fair eli bl and euxfel and ri apollon bringing them to the next level of development and strengthening their leading position the project is well focused and it is deliberately restricted to three enabling technologies which require the most urgent efforts and timely attention by the community highenergy highrepetitionrate amplification highenergy beam transport and optical coating resilience for large optics to reach our goals the major activity within thrill will be organized around producing several prototypes demonstrating a high level of technical readiness our proposal is addressing not yet explored technical bottlenecks such as transport over long distances of largeaperture laser beams via relay imaging using allreflective optics and aims at proposing concrete steps to increase the performances and effectiveness of the industrial community through the codevelopment of advanced technologies up to prototyping in operational environmentsthe project is not only pushing technology it is also offering an outstanding opportunity to train a qualified work force for ris and industry with this in mind the structure of thrill promotes synergetic work fast transfer to industry and integrated research activities at the european level access to the ris will be granted as inkind contribution
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climate effects reduced by innovative concept of operations needs and impacts assessment
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ciconias ambition is to improve the understanding of nonco2 emissions with regards to the current aircraftengine technologies and operating fleet as well as their evolution and their climate effects but with the clear objective to evaluate and develop impact reduction solutions covering several promising mitigation options on flight operations through the definition of innovative dedicated concepts of operations conops and their assessment in comparison to legacy operations ciconia wants to define and assess conops solutions with engagement from all concerned stakeholders airlines with their occ network met providers and air traffic control ciconia mitigation options will offer the best proposal for reduction in climate impacts taking into account both the co2 and nonco2 climate effects a trl4 is targeted at the end of the 3 years projectciconia is composed of the four main topics1 a weather service that will improve weather forecasting capabilities tailored for operational mitigation concepts provide technical enablers definition and recommendation for long term improvement that will feed a better understanding of the stakes2 a climate enabler that will improve climate impact assessment and models tailored for operational mitigation concepts3 conops strategies definition ciconia proposes to further analyse how operational stakeholders could integrate mitigations in their plan or in their tactical operations to mitigate climate impacts a climate enhanced operations conops will be delivered and assessed with representative fast time simulation platforms integrating weather and climate models enabling the evaluation of a large area and long time period these simulations will support the assessment of the complete picture from climate economics and operational impact points of view conducting trades on different assumptions understanding their impact on the decision making and finally providing guidance4 an atm mitigation solution through trials investigate multiple atm strategies for flights to minimise or avoid persistent warming contrails through operational trials and data analysis this solution will focus on reducing the climate impact of nonco2 components specifically by minimising crossings of persistent highly warming contrails from aircraft in oceanic airspaceciconia aims as well at providing material to authorities and regulators to analyse the appropriate rulemaking that could serve a fair and uniformed framework to minimise nonco2 climate effects in a global environmental centric approach addressing as well co2 regulations aimed at mitigating nonco2 effects through operational measures should be proven effective from a climate benefit standpoint fair from an economic impact on the operators standpoint and operationally feasibleacceptablemanageable an advisory board will federate external organisations who want to take part in the ciconia results
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motivation and engagement in disaster mapping in europe
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we should not be seeing this number of people dying in 2021 from floods it just should not be happening hydrologist h clokes words echoed the widespread shock following the death of 243 people in some of the wealthiest and most technologically advanced countries in the world during the european 2021 floods extreme weather events such as floods and heat waves are expected to increase in frequency and intensity in the future ipcc as communities grow more exposed to hazard risks in addition to state preparedness and urban resilience it is urgent to address public involvement in disaster preparedness dp measures to promote individual preventive behaviour sfdrr 20152030 despite eu advances in disaster maps dm tools and disaster management procedures of community professionalisation dm are used mostly by expert stakeholders but are seldom userfriendly for citizens and current dp initiatives suffer from limited public motivation and engagement people do not exist in a vacuum and social and cultural dynamics play a crucial role in defining risk and motivation to engage in dp thus dp strategies should include a systematic assessment of the impact of sociocultural and spatial factors on peoples motivation and engagement in dp to inform better disaster training the motivation and engagement in disaster mapping in europe medime project proposes a theoretical framework of motivation and engagement and a new disaster training based on interactive hm to investigate motivation and engagement in dp and the use of dm for foreign residents an original sociocultural and spatial model to understand peoples motivation to participate in dp initiatives based on the japanese dp research and measures will be implemented for japan has always been at the forefront of dp for high levels of community engagement and mainstreamed dm project results will increase the impact of eu dp strategies and inform useful dm uses for the broader public
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function of cholangiocytes in chronic liver diseases
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cholangiocytes are the mcholangiocytes are the main cell type lining the epithelium of the biliary tree a network of conduits which drain the liver from bile produced by hepatocytes while the role of cholangiocytes have been broadly studied in the context of cholangiopathies their role in chronic liver disease affecting hepatocytes is often overlooked despite growing evidence that they play a central role in disease progression regeneration and cancer thus understanding the mechanisms controlling the regenerative potential of cholangiocytes is essential to develop new therapies promoting tissue repair or blocking tumour formation however the study of these mechanisms has been restricted by technical and conceptual barriers especially in humanhere we propose to bypass these limitations by developing an innovative program of research combining functional experiments in organoids single cell analyses on human primary tissue and preclinical studies in animal models we will use this approach to specifically address the role of cholangiocytes in chronic liver disease more precisely we aim to uncover the mechanisms driving cholangiocytes activation plasticity and transformation importantly we hypothesise that these different processes are interlinked and share common factors the funchol program will systematically address these questions in the context of nonalcoholic fatty liver disease nafld this chronic disease and its progressive form nonalcoholic steatohepatitis nash represent the most rapidly rising cause of liver cirrhosis worldwide and there is currently no therapy for this major health care challenge overall this multidisciplinary proposal will reveal the molecular interplays by which liver injuries can affect cholangiocytes and how in turn cholangiocytes react to improve tissue repair or to aggravate disease this research will pave the way for the development of new therapeutics controlling regeneration to limit disease progression
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circadian regulation of tanycytes its role in the regulation of rhythmic physiology in health and in circadian misalignment
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the suprachiasmatic nucleus scn of the brain our internal clock synchronizes physiology to the earths rotation using signals from the environment such as light and food intake however in industrialized cities these same signals at wrong times uncouple the internal clock from the environment leading to circadian misalignment such as in night and shift workers who have elevated risks of developing obesity and metabolic syndrome nevertheless effective measures to delay or limit health costs for these people are yet to come recently i described novel vasopressinergic scn neuronal scnavp fibers in the vicinity of nonneuronal hypothalamic cells known as tanycytes that have the ability to sense and transport metabolic cues whether the sensor and transporter functions of tanycytes are regulated in a circadian manner by the scn and whether this regulation plays a role in the development of metabolic impairments during circadian misalignment are unknown thus in the circanycyte project we will seek to 1 determine how scnavp neurons control tanycytic function 2 explore the role of scnavp neurontanycyte communication in circadian alignment and metabolic fitness and 3 determine the contribution of scnavp neurontanycyte miscommunication to the development of metabolic syndrome during circadian misalignment to accomplish these aims i will undergo training in cuttingedge technologies eg ca2 in vivo imaging of tanycytes with simultaneous optogenetic manipulations while i exercise my leadership and management skills by working in a top laboratory using the experience as a launching pad for international collaborations in frontier science in the eu my original angle of research hypothesizing that tanycytes which extend processes outside the bloodbrain barrier are key targets of the scn to regulate metabolism is a strategic choice that promises to uncover new actionable pharmaceutical targets to fight desynchronizationrelated disorders
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drug optimisation in lmics of pregnant hiv women and their infants temporary switch to cabrpv long acting injections
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sustained art use is essential for achieving sdg3 by reducing hiv burden and promoting maternal and infant health ensuring consistent adherence and engagement in care is crucial to achieving unaids 959595 viral suppression targets in treated individuals by 2030 despite arts success low adherence presents a significant barrier to maintaining longterm viral suppression challenges are notably heightened in postpartum wlhiv as transition into motherhood introduces a range of changes and stressors that can significantly impact adherence therefore theres an urgent need to prioritise interventions enhancing engagement and promoting adherence inorder to achieve viral load suppression and prevent mother to child transmission dolphin3 aims to operationalise an implementation project using a mixed methods approach to generate evidence on optimal use of longacting injectable art as a strategy to improve adherence rates and overall health outcomes among postpartum women in south africa and uganda the projects objectives are to i establish effectiveness of a temporary switch to cabotegravir cabrilpivirine rpv la as a bridging strategy during breastfeeding ii explore strategies to safely reestablish oral art after discontinuation of cabrpv la iii explore maternal infant and breastmilk pharmacokinetics and iv engage with stakeholders to generate insights for sustainable future deployment of lai the dolphin consortium possesses a proven track record in conducting clinical trials specifically in the population of women initiating art late in pregnancy our proposed project aligns with the edctp3 broader objectives of evaluating the reallife impact of existing interventions in women and childrens health and improving maternal neonatal and child health in subsaharan africa our proficiency in implementation research empowers us to transform our research findings into practical recommendations for healthcare systems and policymakers
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a breakthrough technology designed to preserve sight and halting vision loss associated with a range of retinal disease by preventing the death of key retinal cells
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i am the ceo and cofounder of seabelife a french biotechnology company developing firstinclass drugs to treat severe pathologies affecting our vital organs for which there are no effective treatments we develop an innovative therapeutic approach protected by 4 patents and with a lead program to treat acute liver failure and a second program to preserve sight and halting vision loss associated with a range of retinal disease by preventing the death of key retinal cells we are developing a firstinclass drug based on a dualtargeted approach capable of stopping directly and simultaneously two forms of regulated cell death pathways known to be involved in triggering of numerous acute and chronic pathologies and contributing to organ damage our molecule protects the cells prevents tissue damage and finally preserves and restores organ function seabelife is the only company worldwide developing such a therapeutic approach our molecule has a direct protective effect on cells and has the potential to prevent evolution to severe lifethreatening form we have already obtained very convincing in vivo results in several highly predictive models our molecules were tested on pharmacologically relevant murine models and have shown no toxicity and strong efficacy seabelife is composed of an experienced and complementary operational team managing by two women and supported by a scientific and strategic advisory board with scientific and medical experts of extensive expertise in drug development we have already raised 43m to develop our technology and we are ready to bring our molecules to the clinic and validate its safety and efficacy the main milestones over the next 2 years will be the production of compliant clinical batches and the realization of phase 1 and phase 2a clinical trials the womentecheu award and funding will allow us to gain visibility as women entrepreneurs and also to take an important step in our preclinical development for eye diseases
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untangling the biologic and social causes of low fertility in modern societies
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highincome countries are experiencing both unprecedentedly low and increasingly polarized fertility with growing social gradients in childbearing key theories on fertility patterns are based on the empirical observation that until recently fertility remained comparatively high in genderegalitarian countries with strong support for families since 2010 many of the countries that provided evidence for such theories have reached recordlow fertility this confronts the scientific paradigm of the key drivers of fertilitybiosfer investigates how social biological and psychological factors work together to produce the observed patterns levels and variation in fertility among young adults and to what extent the fertility decline and the related polarization can be attributed to social vs biomedical factors our multitheory approach leverages ideas from several disciplines and proposes that the existing theories must be complemented with concepts of risk aversion and information intergenerational transmission of fecundity epigenetics and beyond in order to understand modern fertility behaviour we develop theoretically informed falsifiable hypotheses that we test against the two richest populationbased longitudinal pregnancy and pubertal cohorts in the world moba in norway and the dnbc in denmarkwe offer a uniquely integrative lifecoursebased approach that is neither social or biomedical but combines central ideas from both and evaluates the biosocial determinants of the key transition points from fetal life through puberty and partnering into planned unplanned partnered and unpartnered childbearing we study the social biomedical and psychological forces their interactions and intergenerational forces as they operate throughout the lifecourse to produce the modern lowfertility landscape the results will help to provide a novel biosocial framework for understanding the lifecourse processes that drive contemporary fertility patterns
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breakthrough technology for plastic and rubber waste circular tpe
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plastics and rubbers are broadly used to produce different products unfortunately their waste does not degrade and remain in the environment an increasing amount of generated plastic and rubber waste requires suitable methods for their recycling one of the greener applications of both materials is to use them in the production of thermoplastic elastomers tpes however made in this simple but inefficient way tpes show poor mechanical performance as a result of incompatibility of polymer blends hence their applications in industry are very limitedat ecopolplast we have created a process that allows mixing recycled scrap tyres with postconsumer plastic creating circular ecoplastomers tpes that are the greenest tpes available globally made exclusively of discarded recycled plastic and recycled tyre rubber and without any chemicals and additives we have confirmed that our technology works trl 6 and now need eic accelerator support to scale up the technology
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advanced structure preserving lagrangian schemes for novel first order hyperbolic models towards general relativistic astrophysics
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alchymia will make substantial progress in applied mathematics targeting longtime stable and selfconsistent simulations in general relativity and high energy density problems via the development of new and effective structure preserving numerical methods with provable mathematical properties we will devise innovative schemes for hyperbolic partial differential equations pde which at the discrete level exactly preserve all the invariants of the continuous problem such as equilibria involutions and asymptotic limits next to fluids and magnetohydrodynamics key for benchmarks and valuable applications on earth we target a new class of first order hyperbolic systems that unifies fluid and solid mechanics and gravity theory this allows to study gravitational waves binary neutron stars and accretion disks around black holes that require the coupled evolution of matter and spacetime here high resolution and minimal dissipation at shocks and moving interfaces are crucial and will be achieved by groundbreaking direct arbitrarylagrangianeulerian ale methods on moving voronoi meshes with changing topology these are necessary to maintain optimal grid quality even when following rotating compact objects complex shear flows or metric torsion they also ensure rotational invariance entropy stability and galilean invariance in the newtonian limit the breakthrough of our new finite volume and discontinuous galerkin ale schemes lies in the geometrical understanding and high order pde integration over 4d spacetime manifolds the highrisk highgain challenge is the design of smart dg schemes with virtual boundpreserving genuinely nonlinear datadependent function spaces taking advantage of the voronoi properties finally it is an explicit mission of alchymia to grow a solid scientific community sharing knowhow by tailored dissemination activities from toplevel schools to carefully organized international events revolving around personalized interactions
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the doctoral rift science network for the energy transition
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talents is a european based research network aiming to train early career researchers with the interdisciplinary sciencedriven understanding and skills that are the foundation to develop new sustainable solutions for the global challenges of the energy transition our joint research focuses on continental rifts which are key regions for geothermal energy carbon capture and storage for new resources such as native hydrogen as well as highrisk human habitats due to geohazards such as earthquakes and volcanic activity we believe that only if we better understand the natural process chains that shape rifts and passive continental margins by investigating key natural laboratories characterising rift initiation east african rift rift maturation gulf of corinth in greece central european rifts and continental breakup west iberian margin we will obtain key knowledge for a safe and sustainable exploration for new carbon free energies talents fuses research and training at 18 beneficiaries and academic partners that are among the world leaders in the study of rift systems and 11 companies that are actively involved in the energy transition the 12 phd projects address fundamental scientific aspects of rift system processes collectively bridging several orders of magnitude of spatial and temporal scales each doctoral candidate is linked to 1 an academic partner to complement and broaden their scientific training 2 to a dedicated industry partner to acquire industryrelevant skills and preview possible nonacademic career paths and 3 to a media contact to actively train in communicating their science to the public training by research and interaction will be complemented by various forms of education spanning a wide range of topics to develop scientific and professional skills to establish ethical standards and to widen career perspectives
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past and future highresolution global glacier mass changes
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worldwide glaciers are losing mass which affects global sealevel river runoff freshwater influx to the oceans glacierrelated hazards and landscape changes with implications for human livelihoods and ecosystems hence accurate estimates of past current and future glacier mass variations at a high temporal and spatial resolution are key to effective adaptation strategies however previous massbalance reconstructions and projections have relied on scarce observations with limited spatial andor temporal resolution as well as overparameterized insufficiently constrained and highly simplified models the latter necessitated by high computational costs incurred by the global scaleglacmass will propel the current stateoftheart of globalscale glacier reconstruction and projection forward in unprecedented ways by delivering a fundamentally novel and internally consistent physicallybased modelling framework that draws for the first time on a global scale on both data assimilation and modern machine learning techniques facilitated by emerging globalscale glacierrelated satellitederived data the framework will be used to reconstruct multidecadal past glacier changes and make policyrelevant multicentury projections of mass and area changes of all 200000 glaciers outside the ice sheets with unprecedented accuracy spatiotemporal detail and computational efficiency and also nowcast present mass changes in a nearrealtime fashion for selected regions the model framework will fuse output from a novel physicallybased glacier evolution model with all relevant observations available for each glacier such as insitu geodetic and gravimetryderived mass balances as well as snowlines and other observations thus simultaneously exploiting the untapped strengths of different types of observational data sets in an optimal manner
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cytokine and microbiota function in gut development spatiotemporal analysis in the zebrafish
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organ development and function are controlled by complex interactions between genetic cellular and environmental factors because these interactions are challenging to study in live organisms their mechanisms remain largely unknown gut development is regulated by microbiota colonization making it a valuable organ for dissecting geneenvironment interactionscytokines small secreted proteins highly responsive to environmental changes regulate immunity and gut function in mammals our data indicate that specific cytokines are also essential for gut development in zebrafish we found that these cytokines are first expressed in gut epithelial cells during development and later their expression is switched to immune cells including innate lymphoid cells ilcs ilcs were discovered in the mammalian gut but their function has not been dissected due to the lack of specific markers having identified the first vertebrate ilc markers in zebrafish we will combine our novel tools together with other unique benefits of zebrafish such as live microscopy easy environmental manipulation and abundant genetic tools to dissect how microbial cues interact with genetic networks to control organ development we hypothesize that gut development is regulated by cytokine signaling that is in turn regulated by crosstalk with the microbiota and the emergence of ilcsour specific aims are to1 characterize the roles of cytokines during gut development2 determine how microbiotacytokine crosstalk controls gut development3 uncover the role of ilcs and cytokine source switching in gut maturationthis project at the intersection of developmental biology and immunology will provide fundamental insights into how symbionthost crosstalk controls organogenesis and a new conceptual framework for the function of the immune system furthermore conservation with the human gut could help identify new therapeutic strategies for common diseases such as inflammatory bowel disease
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diagnostic screening platform to facilitate conflict resolution
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multidoor is a digital platform based on conflict resolution and machine learning expertise to address the comprehensive needs of litigants and recommend their best way forward to resolve their disputes at present litigants attempting to navigate through the civil justice system end up drifting through an incoherent opaque process generally resulting in some form of reluctant compromise while court systems worldwide are investing much effort to increase efficiency a humancentred approach which takes into account litigants needs interests and emotions is lacking multidoor employs an innovative intake screening recommendation system to integrate each litigants or potential litigants specific needs interests and emotions the features of the case and the predicted case trajectory in the legal system resulting in a diagnostic recommendation eg mediation arbitration adjudication outofthebox solutions we describe the activities needed to develop a beta version of multidoor including conceptual framing and validation the activities include a crowdsourcing experiment to accumulate data on users satisfaction with conflict resolutionoriented processing of their disputes developing forecasting models for user satisfaction and developing a machinelearning based recommendation system multidoors benefits include 1 developing a new domain of conflict resolution machine learning via collaboration among data scientists and legal and conflict resolution experts 2 advancing a personalized conflict resolutionoriented response to disputes including to small nonlitigable disputes 3 promoting public trust and social wellbeing by ensuring that parties including those from disenfranchised sectors are informed and supported to selfdetermine how to resolve their disputes 4 answering the current drawbacks of online dispute resolution odr systems which focus mostly on legal issues rather than on the interests of the parties
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contested conditions in the wake of covid19 relations between autobiography media and illness
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autobiographical narratives about contested conditions have been published in western media which often highlight personal experiences of dismissal in health care and public scholarship in medical humanities argues that illness narratives can give voice to affected communities and provide evidence of the experience of illness and disability this approach emphasizes the performative power of personal storytelling and the need to witness but risks to promote a reading of autobiography as a social good rather than as a complex mediated and cultural practice specifically what is insufficiently accounted for is the role of mediality and materiality in autobiographical practices and politics of chronic illness my project is a nuanced study of autobiographies of two chronic conditions long covid the continuous illness after an infection with covid19 and the chronic condition of myalgic encephalomyelitis or chronic fatigue syndrome mecfs are contested and debated in polarized ways in contemporary biomedicine and culture leading to stigmatization and reduced quality of care for those affected i closely examine a selected number of emerging autobiographical forms such as collective storytelling virtual exhibition and artistic microblogs which have been published in germany and in the us 20152023 by analyzing new strategies of communicating illness experience i ask how these media forms and material practices affect and are affected by politics of chronic illness and disability i will integrate a wide variety of methodological approaches from media studies and concepts from disability studies and medical humanities to claim that closely examining mediated and material practices of autobiography opens overlooked relations between illness media and politics that are obscured by the focus on representation the project aims to reframe autobiography within questions of stigmatization and inequality and to reconsider how autobiography is conceptualized and approached in medical humanities more generally combined with innovative approaches of public engagement the project seeks to impact the cultural bias against unexplained illness and to expand my transdisciplinary research expertise at the intersection of cultural studies and medicine
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inclusive and interconnected ecosystem to boost paediatric innovation in europei4kidseurope
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innovation in paediatric health is critical to ensure that children regardless of their age health condition socioeconomic situation or place of birth have access to the lifechanging healthcare solutions they need to growup stronger and contribute to a better society children are not just small adults and they need targeted innovative solutions however paediatric innovation is still elusive there are two main causes for thisi stakeholders perceive paediatric innovation as risky and they just try to adapt adult solutions to childrenii paediatric experts innovators and other relevant stakeholders are scattered in a fragmented ecosystem across europe failing to identify opportunities or deliver effective and harmonized actionthus the unexploited innovation potential is large particularly in emerging and moderate innovator countries to reduce barriers and exploit these opportunities while ensuring equality across different countries the establishment of a european paediatric innovation ecosystem is of paramount importancethe i4kidseurope project builds on an existing successful initiative i4kids and it will expand its activities towards europe in order to enlarge the participation of diverse european paediatric stakeholders and territories the project will allow synergies avoid duplications reduce differences between strong and emergingmoderate innovator territories and strengthen competitiveness to optimise the innovation potential of the european paediatric sector to achieve this we will analyse the landscape of paediatric innovation in europe as well as the barriers that emergingmoderate innovator countries face i4kidseurope will offer an interconnected paediatric innovation ecosystem that will capacitate its underrepresented actors and make them participate in the design of the future european paediatric innovation ecosystem
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reconstructing the origin and functional diversification of eukaryotic heterochromatin
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chromatin functionally organizes all eukaryotic genomes genomic regions within heterochromatin are transcriptionally repressed and aberrant expression can be lethal heterochromatin is characterized by specific histone modifications but readerrepressor proteins are directly responsible for preventing dnatemplated processes recent studies suggest immense functional diversity of readerrepressor proteins that remains poorly understood understanding this diversity will reveal the ancestral composition and capabilities of eukaryotic heterochromatin and uncover unique heterochromatic systems while exploring heterochromatin in species across the eukaryotic tree of life is key most lineages have not been investigated due to complications with chromatin isolation culturing and genetic manipulation to address these fundamental biological questions and overcome technical barriers i will use a recently developed mass spectrometry method to identify proteins associated with known heterochromatic modifications in 19 species cultured in the sebpedrs laboratory representing all major and several earlybranching eukaryotic lineages to overcome genetic manipulation limitations i will create a synthetic platform to heterologously assess readerrepressor functions of proteins in budding yeast i will use this system to functionally characterize new regulators of heterochromatin from diverse eukaryotes finally i will integrate these and other genomic data in a comparative framework to reconstruct the ancestral composition and evolutionary diversification of eukaryotic heterochromatin overall my project will comprehensively identify the functional conservation and diversity of eukaryotic heterochromatin and create a powerful genetic tool to further explore chromatin function and evolution
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intelligent circular lifecycles of industrial robots outdoor power products and electric vehicles
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circularity has opened up new markets and business opportunities domestically and outside the eu however opportunities are being missed due to low reuse and recycling rates icircular3 creates a cohort of future leaders in research policy and business through its innovative training programme focused on the circular economy three leading universities supported by four industry partners will address the incorporation of circular economy principles using digital technologies throughout the product lifecycle for three innovative and strategic sectors for the european economy industrial robots outdoor power products and electric vehicleseach sector will explore the possibilities of a circular lifecycle through four perspectives1 product and service design exploring opportunities for circularity in the design of outdoor power products electric vehicles and industrial robots2 reverse supply chains understanding and overcoming recovery barriers in these industries3 users and stakeholders ensuring stakeholder engagement in the transition towards more circularity for instance by engaging outdoor power product consumers in the development of reverse logistics systems and improving the recycling rates of electric vehicles from a consumer perspective4 systems developing digital tools and decision support systems that foster circularityicircular3 will recruit and train 9 researchers to conduct sectorspecific projects related to circular lifecycle perspectives combined together the projects will contribute to the development of new guidelines and digital tools for the integration of circularity in industry as well as the identification of crosssector commonalities the strong academicindustry interaction in icircular3 will ensure the relevance of each research project researchers will receive highlevel industryled research training and professional development courses with a view to open up their career perspectives
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gnssr satellite earth observation
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gnssr is a technique to carry out earth observation based on reflections on the ground or sea or ice of signals originating from gnss global navigation satellite system signals the proposed project consists of educating a new generation of experts at doctoral level able to bring a qualitative leap to this technology the scientific and technological goal consists of developing such systems based on a synchronized constellation of cubesats an important advantage of this arrangement is the very low cost of cubesats and the possibility to increase resolution based on beamforming from the satellites ground truth as well as some of the methods will originate from nearfield radar technology this will require further research on all segments of gnssr technology and beyond launching and adjustment of cubesat formations rf synchronization interferometry between moving platforms calibration of rf frontends ground testing making use of drones cubesat systems onboard processing data transfer and analysis translation into ground truth and into predictions important for climate change studies and for optimal territory management the project may also benefit to other technologies making use of interferometry such as radioastronomy and phased array based communications it is also expected to assist industry segments making use of gnss signals such as precision agriculture forestry and sea and land management
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universal geometric transfer learning
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in this project we propose to develop a theoretical and practical framework for transfer learning with geometric 3d data most existing learningbased approaches aimed at analyzing 3d data are based on training neural networks from scratch for each data modality and application this means that such methods first ignore the wider information overlap that might exist across different tasks and object or scene categories and second tend to generalize poorly beyond the specific scenarios for which they are trained even more fundamentally the majority of existing techniques are limited to problem settings in which sufficient amount of training data is available making them illadapted in many practical applications with limited supervisionin this project we suggest to take a fundamentally different approach to geometric data analysis rather than designing independent application or classspecific solutions we propose to develop a theoretical and practical framework for geometric transfer learning our main goal will be to develop universallyapplicable methods by combining powerful pretrainable modules with effective multiscale analysis and finetuning given minimal taskspecific data the overall key to our study will be analyzing rigorous ways both theoretically and in practice in which solutions can be transferred and adapted across problems semantic categories and geometric data typessuch an approach will open the door to fundamentally new tasks and modeling tools applicable to any geometric data analysis scenario regardless of the amount of training data available this would allow for example to track the evolution of biological systems by studying the underlying complex 3d shape dynamics or to analyze variability in object and scene collections consisting of 3d scans of previously unseen shape categories crucial in cultural preservation and life science applications among myriad others
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shining light on saturated gluons
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in this project the properties of hadronic matter with emergent nonlinear saturation phenomena at extremely large parton densities are theoretically determined this is achieved by studying quantum chromodynamics qcd describing the strong interactions between quarks and gluons at high energiesthere are solid theoretical arguments formulated in the color glass condensate cgc effective field theory to suggest that saturation effects play a major role in hadronic interactions at high energies however so far no clear signal of gluon saturation have been observed this will change when the electronion collider eic starts to measure photonmediated electronnucleus collisions allowing for precision studies of high density hadronic matter in heavy nucleiwe develop the cgc approach to highenergy qcd to the level where for the first time multiple scattering processes can be simultaneously described from the unified framework at nexttoleading order accuracy these developments are necessary to bring the theoretical framework to the level required to probe nonlinear dynamics in the eic erawe extract the nonperturbative proton structure from global analyses and determine if nonlinear qcd dynamics is observable in current collider energies we calculate predictions for the eic and determine how different processes at the eic probe gluon saturation before the eic photoninduced processes at high energies are available at the lhc in ultra peripheral collisions that we use to extract for the first time the effect of nonlinear dynamics on the nuclear highenergy structure at nlo accuracy the fundamentally important results are applied to develop a new description for the initial condition of heavy ion collisions where quark gluon plasma qgp is produced we determine the effect of nlo initial state description on the extraction of fundamental qgp properties and quantify the synergies between the lhc heavy ion program and future eic
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city based interventions to stimulate active movement for health
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citymove adapts and implements the who global action plan on physical activity gappa in six cities across three continents and develops a crosscontextual evaluation framework for transferability and scalability physical activity is a key behavior to reduce the ncd burden including protecting against cancers and type 2 diabetes there are many evidencebased interventions for cities to promote physical activity yet they remain underimplemented with a wholeofsystem approach particularly lacking and often fail to target the least active or vulnerable groups knowledge gaps are a how to adapt b successfully implement and c evaluate interventions and d how to transfer lessons to other interventions target groups and contexts in partnership with the cities we identified interventions targeting individuals across the life course particularly vulnerable and least active groups aligned with the gappa domains of active people societies environments and systems citymove will 1 develop a citygappa theory of change and operationalise assessment measures 2 adapt citygappa to six cities engaging stakeholders in each context 3 support cities in successful implementation through action research in living labs 4 assess reach adoption feasibility fidelity and sustainability of selected interventions in each city 5 improve the development and utilisation of routinely collected data to support successful implementation 6 generate crosscontextual evidence on implementation evaluation and scalability through multicriteria decision assessment for 12 interventions in six cities and 7 generate global capacity through regional communities of practice citymove results lead to increased physical activity by target populations contributing to reduced premature ncd mortality and to adaptable solutions ready for takeup by implementers
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targeting epsteinbarr virus infection for treatment and prevention of multiple sclerosis
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multiple sclerosis ms is a chronic inflammatory and degenerative disease of the central nervous system cns it constitutes the most common nontraumatic cause of neurological impairment among young and middleaged people and represents a major healthcare burden our recent research strongly implicates infection by the epsteinbarr virus ebv as the leading cause of ms but detailed understanding of the mechanisms how ebv contributes to the disease and whether targeting ebv could prevent or improve the course remain unresolvedto meet these challenges we have established a consortium with extensive experience in neurology and ms genetics virology and ebv epidemiology immunology clinical trials artificial intelligence as well as stakeholder involvement and responsible research and innovation rriby combining this expertise the consortium takes advantage of highquality health registries existing research cohorts of persons with ms and prospective randomized clinical trials of antiviral therapies targeting the ebv infection in ms the ambitious goals are to answer the questions why only a few ebv infected persons develop ms and define the underlying mechanism of this process as well as clarify if targeting the ebv infection can prevent ms or improve the disease course by answering these questions we would meet the challenges defined in the current call relationship between infections and noncommunicable diseases we would contribute with knowledge to reduce disease burden by providing the health care system with new knowledge to better understand the cause of ms including host risk factors that influence the development of the disease we would also provide a basis for new or improved tools to prevent ms or disease progression healthcare practitioners will gain access to knowledge to guide them on preventive measures and of those persons at risk of developing ms with the ultimate goal of eradicating the disease
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fertiliser product recovery from secondary raw materials using best available techniques
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fertitec builds upon the knowledge gained from previous eufunded projects such as novafert ferplay mainstreambio soilutions sumanu agrotechnology atlas bferst novafert cinurgi manure standards susfert nutriknow nutriman etc which have explored the potential of waste management and nutrient recovery from various perspectives by integrating the insights and technological advancements from these previous initiatives fertitec is positioned to deliver a comprehensive solution for waste recycling and sustainable fertiliser production from secondary raw materials the principal objectives of this group of related projects that fertitec aligns with and supports are to transform waste into highquality fertilisers promote a circular economy and mitigate environmental impact thereby aligning with the eus goals of sustainable agriculture waste reduction and bioeconomy enhancement fertitec is commited to develop competitive fertilisers that are not only benefit agricultural yield but also promote a circular economy model aligning with the eus strategic focus this dual focus of environmental sustainability and economic viability resonates with the objectives of our previous projects which aimed to boost the marketability of biobased products and harmonise global sustainability certification systems respectively by involving key actors from the agriculture sector and facilitating multistakeholder discussion through our kep fertitec fosters a communitydriven approach to boost sustainable innovation in the fertiliser sector we seek to make a tangible impact at national and regional levels by deploying our best availalbe fertilising techniques in several eu countries as well as extrapolationg our outcomes to the african union landscape by providing practical recommendations and guidelines overall with fertitec we aim the adoption of our alternative fertilising products and the wider transformation of the agricultural sector globally
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exploring natural selection due to the black death and continuous human population genetic structure
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the study of ancient human dna has been revolutionary in identifying largescale admixtures and genetic variants subject to natural selection yet key knowledge gaps persist first ongoing genetic mixing within spatially continuous populations is poorly understood second the underlying selective pressures particularly of infectious diseases remain debated to bridge both gaps i propose sequencing 500 victims of the black death one of the deadliest pandemics in human history from a site in central europe and using this data synergistically with novel computational tools to make two breakthroughsmy first objective is to pioneer linking a large number of ancient and modern genomes through shared long haplotypes known as ibd segments ibdsharing with modern genomes across europe will reveal for the first time how genetic ancestry spread across space starting from a large sample of a singular position and time new inference tools using ibdsharing will offer unprecedented insights into the european population structure of recent centuries including mobility and effective population densities and address a critical lack of population genetic models for spatially continuous populationsthe second objective is to pinpoint genetic variants relevant to black death mortality observing the removal of alleles for the first time in molecularly confirmed plague mass graves will directly link an infectious disease and the resulting natural selection the findings will decisively resolve longstanding debates regarding the human selective impact of the black deathboth ibdsharing with modern europeans and selection screens will greatly benefit from the large sample size of medieval genomes the synergy between the new analysis and tools i propose will break new ground for two key topics in population genetics relevant beyond humans inferring the structure of continuous populations and the impact of natural selection
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from expectation to action
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the freetoact project involves 16 experienced partners and is the legacy of 16 years of a collective participation to the ern as a consortium we will organize events in 16 different french cities sharing the same objectives and approach to science engagement and most of the activities and involving local researchers freetoact is based on two connected themes in 2022 the public will discuss the functioning of research through an attractive theme the unexpected which will bring surprises to the visitors while discussing predictability in research in the process in 2023 researchers and the public will debate together around the theme our futures these themes foster the quality of the discussion with researchers a key factor in enriching the publics vision of science in society and renew ern proposition for the public and the press during the events we will create warm and aesthetic encounters and design playful activities to be shared by researchers and the public the 2800 researchers involved in the project will be coached and trained by mediators all the local organizers have extensive experience in conducting researcherpublic meetings thus researchers at school activities will be organized thanks to our existing networks adults will also be able to participate through a new edition of the great participatory experiment in 2023 a research team will propose participatory research for the ern in 16 cities online activities will be proposed to interact with the public located outside our 16 cities the french ministry of culture will financially support the event for the 5th year fostering the participation of researchers in humanities and social sciences
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panel recycling and integrated solar material
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irena 2016 estimates that the cumulative pv panels waste volumes will reach 78m tons by 2050 8m tons by 2030 pv panels contain silver and silicon which if recycled represent a source of valuable and critical raw materials for the energy transition 80b by 2050 today many recycling facilities only recover bulk materials like aluminum frames and lowquality front glass the remaining material is often incinerated disposed or downcycled even though it contains silver and silicon which together account for twothirds of the monetary value of a silicon pv panels materialsto take advantage of this opportunity solar materials has developed a patented layerbylayer thermomechanical recycling process based on infrared heating to delaminate and recover all valuable raw materials contained in pv panels solar materials recycling process is the 1st in the world to recover all raw materials from solar modules in an economical and energyefficient way this enables us to achieve the highest profitability in the industry ebitda margin of 50 even with recycling fees at 50 lower of that of current pricessolar park owners enerparc and leading metal smelters and refineries in europe stemin umicore have already formally expressed their interest in our recycling services and material products moreover we have validated our sales prices with quotes and analysis for glass prezero reiling copper cables remondis aluminum stemin hydro silver umicore and silicon circular siliconwith this project we will setup and operate an industrialsized commercial pv module recycling plant in germany with capacity to process 8400 tons of pv panel waste per year by 2033 we expect to own and operate 33 recycling facilities globally with a cumulated annual capacity of 277m tons by then we would have recovered 710 tons of silver 46381 tons of silicon and 215237 tons of aluminum accounting for over 45m tons of avoided co2eq emissions
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