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breeding european legumes for increased sustainability
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the aim of belis is i to increase the competitiveness of the eu and associated countries legume breeding industry by improving the methodologies and the governance structures of the breeding sector ii to design conditions that allow an efficient delivery of the achieved genetic progress to the breeders and seed industry and to the other actors registration offices extension services feed and food industry farmers the project will focus on seven forage crops and seven grain crop that are currently grown to produce feed for ruminants cattle sheep goat and monogastric animals pig poultry food as is or after processing or to deliver ecosystem services belis has three main objectives 1 to develop tools and methodologies for costeffective breeding programmes and deliver proofs of concept with and for breeders 2 to facilitate the economic and regulatory environment variety registration variety recommendation and business models 3 to implement an efficient ambitious and durable transfer of innovation through the belis platform that includes a network of breeders and actors from scientific research extension services and seed food and feed industries as well as a training portfolio by enabling the creation of improved varieties in many species adapted to different areas and uses in europe this project is relevant for the destinations towards biodiversity and ecosystem services mainly contributing to access to a wider range of crops and breeds with a broadened genetic base is improved in line with global biodiversity commitments it also supports the practices in agriculture and forestry support biodiversity and the provision of other ecosystems services in addition belis will have a positive input on natural biodiversity reduction of air and water pollutions and farming system sustainability
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chipscale visibleinfrared imaging sensor
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according to the world health organisation road accidents are the eighthbiggest cause of death worldwide bad weather dangerous road conditions and distracted or fatigued driving account for nearly 70 of all accidents current driving monitoring systems dms and advanced driverassistance system adas underperform in harsh conditions do not guarantee high standards of security and simply do not provide the needed supportive information to drivers swir shortwave infrared is what is missing swir light thanks to its peculiar physical properties allows for better vision in critical visibility conditions such as fog night dusk and dawncheers chipscale visibleinfrared imaging sensor aims at developing a multispectral image sensor which thanks to a unique patented electronic structure is capable of selectively detecting the visiblenear infrared visnir and swir regions of the electromagnetic spectrum being based on si and ge photodiodes monolithically integrated in a single device eye4nir technology is fully compatible with mainstream foundry processes harnessing their scalability and costefficiency to its advantage as opposite tocurrent swir imaging technologiesthe robustness of our approach is proven by very promising results on labscale prototypeswithin cheers eye4nir a fabless image sensor supplier aims at manufacturing a first hd visswir chip ready for highvolume productions target market is automotive where the demand for dms and adas is growing also because of regulatory constraintsand where price makes the difference cheers is effective reliable and versatile being an enabling technology it can be implemented in other application domains such as industrial automation consumer electronics and noninvasive quality controlsemiconductors are key for europes competitive leadership in the era of the digital economy eye4nir aims to grow and become a key fabless player in the ecosystem
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investigation of the ignition of a wallimpinging jet on a hot surface fuel jet and liquid gas jet
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accidental ignition of liquid fuels is a critical safety and economic concern for the chemical aerospace automotive and petroleum industries a fundamental understanding of ignition processes is crucial to reduce accidents and exacerbated pollution emissions through safer and more optimized designs even though hot surface ignition is a wellrecognized hazard it is only superficially understood and safety guidelines tend to oversimplify the phenomenon hephaestus project is born from the will of two recognized research centers to merge their expertise to address this issue the von karman institute for fluid dynamics vki in belgium and the explosion dynamics laboratory edl of the california institute of technology caltech usahephaestus aims at improving the knowledge on the ignition processes of a jet impinging a hot surface a world unique experimental setup will be designed to provide an indepth optical investigation of the fuel jet ignition an experimental database will be generated analyzed and diffused into the scientific and safety community the data will be first used to test the existing numerical models it will be extensively analyzed to detail the different ignition mechanisms finally it will be applied to test engineering models and propose new safety guidelinesvki is developing a new laboratory on the use of flammable liquid gas for propulsion the knowledge acquired during the projects first stage about experimental analysis of ignition mechanisms will be used to support the development of this new leadingedge laboratory an existing vki setup will be adapted for ignition characterization by implementing the newly learned experimental technique and the experimental protocol will be optimizedhephaestus project will improve safety via an enhancement of the ignition processes understanding and the diffusion of a fundamental scientific database to be used for future research
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designbased datadriven decisionsupport tools producing improved cancer outcomes through usercentred research
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patients with cancer often have to make complex decisions about treatment with the options varying in risk profiles and effects on survival and quality of life datadriven decisionsupport tools dsts have the potential to empower patients support personalized care improve health outcomes and promote health equity optimal decisions also for underserved groups however dsts currently seldom consider quality of life or individual preferences and their use in clinical practice remains limitedto address these challenges the 4d picture consortium will further develop a promising methodology metromapping to redesign care paths that include novel dsts we will better predict treatment outcomes by developing innovative algorithms and incorporating patient experiences values and preferences using aibased models in cocreation with patients and other stakeholders we will develop datadriven dsts for patients with breast cancer prostate cancer and melanoma we will evaluate these dsts as part of metromapping as well as standalone to ensure their sustainability as well as addressing social and ethical issues we will explore the generalizability of metromapping and the dsts to other types of cancer and across other eu member statesimproved care paths integrating comprehensive dsts will empower patients their significant others and health care providers in decision making and strengthen care at the system level by improving resilience and efficiency whereas the 4d picture consortium includes leaders in modelling ai decision making citizen science service design ethics risk communication and policy making this project will impact clinical practice and science across europe and beyond
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strategic energy technology for industry in europe
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the csa strategic energy technology for industry in europe setindeu is responding to the call horizoncl52022d40206 to propose a structured secretariat for supporting and strengthening the activities and outcomes of the iwg6 on energy efficiency in industry the consortium will support the iwg6 to advance the monitoring and revision of the action 6 implementation plan ip with the aim of reaching technology targets collectively across set plan countries making eu industry less energy resource and emissions intensive and more competitive for that purpose the future needs of the process industry the ri targets and the emerging policy priorities will all be taken into consideration by engaging the iwg6 stakeholders in key activities with industrial and research associations and fora specifically strengthening the relations dialogue and exchange with the other set plan iwgs and the etips
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unravelling biocontrol and physiological challenges in pine wood nematode pathosystem
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pine wilt disease pwd caused by the nematode bursaphelenchus xylophilus pine wood nematode pwn is one most devastating forest diseases worldwide this pathology was detected in europe in 1999 and future climatic scenarios point pwd will spread in the next decades threatening more than 60 of native range of pinus sylvestris and p pinaster in parallel adaptation of woodlands to climate change and its effect in tree defense against this pathology remain unclear biphynema will investigate how pines will react to those stress sources to better understand ecophysiological and pathogenic procedures that will drive their response in the middle term the project has four research objectives a to evaluate physiological response of two p pinaster genotypes susceptible and resistant infected by pwn under two different environmental conditions according to ipcc scenarios b to characterize functional response of infected seedlings and pwns by dualtranscriptomics approach in the aforementioned scenarios c to monitor populations of pwnmutualistic bacteria during nematode infection and d to investigate virusbased control potential using phages against pwnassociated bacteria biphynema combines transcriptomics with tree ecophysiology from an integrative point of view ecophysiolomics to achieve a holistic description of disease development in addition the project integrates that approach with pathology and applied virology resulting in an original and interdisciplinary research with high potential for innovative findings biphynema provides a detailed personal career development plan focused in reinforcing autonomous research profile of the fellow moreover the project will transfer new knowledge between forest researchers foresters and society using the most suitable means in each case biphynema adheres to key strategic orientations of horizon europe program and addresses the need to develop ecofriendly methods for forest protection
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materialism and geographic specificity in the philosophy of film
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films are made out of materials at specific moments in specific places but while philosophy of film and filmphilosophy are today as strong as ever a certain set of antimaterialist assumptions continues operating in these fields philosophers of film tend to treat questions of the materiality of the medium as subordinate to representational and narrative contents likewise philosophical understandings of the ethical and social significance of the filmic medium continue to focus on the contents of films rather than the nature of the medium itself these approaches can be surprising from the materialist perspectives of avantgarde and experimental cinema but while philosophy of film and filmphilosophy have not yet incorporated the lessons of the materialist avantgarde traditional film theory has tended to treat certain geographically and nationally specific avantgardes as though they were geographically neutral somehow standing in for the rest other filmic avantgardes belonging to other geographic regions even those articulating compelling and innovative material views of the medium have gotten lost nevertheless a unified materialist philosophical view of film emerges once we pay attention to the iberoamerican avantgarde which we can call recurrentist materialism indeed paying greater attention to recurrentist materialism and the iberoamerican avantgarde can provide an important alternative to dominant antimaterialist and geographically natural pictures in contemporary philosophy of film and filmphilosophy this is what the researcher will undertake throughout the 24 months of the fellowship through scientific articles the preparation of a book manuscript teaching the organization of a colloquium on the philosophy of film and a twopart film series which will include invitations to actually practicing filmmakers as well as two workshops for philosophers on the technical and material properties of film
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boosting the one health research excellence and management capacity of the estonian university of life sciences
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the aim of the ohboost project is to increase the research and innovation excellence as well as the management and administrative capacities of the estonian university of life sciences emu with a focus on the institute of veterinary medicine and animal sciences in the field of one health one health is an increasingly important research domain focused on different dimensions of how human animal and environmental health are inseparably linked its core lies in the understanding that humans and animals share the essentials of life the genome diseasecausing organisms health welfare and the environment and ecological ecosystem that affects both humans and animals already having in place strong preconditions to conduct excellent research in the field previous research infrastructure and equipment emu now seeks to advance its knowledge and skills in one health and ultimately become one of the most acknowledged research organizations in the field in europe and worldwide as one of the means to move towards this goal emu will team up with two of the leading universities in the related fields of one health the university of helsinki uh and the university of milan unimi the university of tartu ut will also join the project as emus longterm local cooperation partner who offers human health expertise to support emus expertise in animal health and the environment so that one health topic are explored from a multidisciplinary and holistic perspective the ohboost project seeks to combine emus and uts competences to strengthen one health research in estonia mentored by uh and unimi this includes knowledge transfer and capacityraising activities as well as joint efforts to increase emus research profile and international visibility
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synthetic healthcare data governance hub
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the objectives of search are truly groundbreaking seeking to enable extensive data aggregation and analysis while safeguarding the integrity and privacy of original datasets through synthetically derived proxies this initiative is designed to address biomedical challenges in europe and offer translational solutions that will ultimately contribute to the advancement of personalised medicine unlike traditional datasharing platforms that mainly focus on technical obstacles search adopts an innovative approach by addressing legal ownership and subject privacy concerns it specifically targets distributed institutional repositories that are hesitant to share multimodal clinical data overcoming security concerns through a combination of clinical synthetic data proxies and a federated learning framework until synthetic data proxies gain wider acceptance this combined strategy aimed at alleviating security concerns facilitates the scalability required for ai analysis and promotes creative publicprivate data collaborations search will offer advanced data federation capabilities incorporating unique synthetic data generation features to create various data types including those not comprehensively addressed currently eg wearable device data image sequences and genomic data through curated access to these novel digital tools search will facilitate convenient access for the healthcare industry and research community to address bottlenecks and challenges in the development of novel tools for personalized prevention diagnosis and treatment based on explainable ai moreover search will provide agreedupon gold standard synthetic datasets for evaluating the performance of biomedical ai solutions search aims to consolidate european innovation and research endeavours by promoting public and private collaborations to unlock the potential for innovation in the digital healthcare sector
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reliable efficient and fast industrial internet a highresilience lowlatency api acceleration for global and interplanetary industrial services
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existing major industries run on udp protocols and have high latency and low resilience in their communication networks affecting their output and causing millions of euros in losses or unrealized revenue examples of the highest impacted fields include the mining energy maritime and space sectors tcpbased protocols can overcome these challenges but are limited by transmission delaysdelta cygni labs has developed xrtc an elastic and resilient tcp based protocol for api acceleration together with the european space agency esa to serve delay and disruptionprone business cases we offer faster communication better connectivity and enhanced control over internal communication addressing daytoday challenges across mining energy maritime and space sectors and allowing them to draw business value from spacegrade communication capabilities with the help of the eic accelerator we will launch the european deeptech xrtc to the key verticals perform market validation and expand into the global market
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an innovative virtual reality based intrusion detection incident investigation and response approach for enhancing the resilience security privacy and accountability of complex and heterogeneous digital systems and infrastructures
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organisations across the sectors significantly benefit from digital transformation to support evolving business models services and customer experience despite the benefits of digital infrastructure adoption there are numerous security challenges that could pose any digital disruption and risks for the critical service delivery and overall business continuity there is a need to understand the overall digital infrastructure context and analyse and predict the possible threats and incidents in realtime so that quick and accurate responses can be taken into consideration for ensuring resilience of service delivery additionally collaborative response and sharing of threat intelligence information is necessary to create overall awareness and increase the response capability of all stakeholders within the ecosystem cybersecdome will integrate advanced virtuality reality vr to extend the capability of the security solutions aiming to enhance security privacy and resilience of the digital infrastructure the project will consider aienabled security solutions to provide a better prediction of cybersecurity threats and related risks towards an efficient and dynamic incident management and optimise collaborative response among the stakeholders within the digital infrastructure ecosystem cybersecdome project is built on a collaboration of 15 organisations from 6 eu member states it de ie se el cy and 2 affiliated countries uk ch which is composed by 5 industrial partners 6 scientific partners and 5 smes the project will be coordinate by maggioli spa
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wargames as experiments strategy and unintended escalation wesue
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we have no been this close to nuclear conflict since the cuban missile crisis un secretarygeneral antnio guterres as reported by the bbc acknowledged this fact recently at the 2022 review conference of the nonproliferation treaty npt today humanity is just one misunderstanding one miscalculation away from nuclear annihilation examples are many at present where the specter of nuclear escalation is real in the context of the ukrainian war foreign minister lavrov and president putin have both made clear the help of nato to kiev increased made nuclear war a possibility as reported by bloomberg he stated the danger is serious real it cant be underestimated this followed the order by president putin in february 2022 to put the nations nuclear forces on high alert as such it is now more than ever crucial to understand the causes of the nuclear restraint we have experienced until now so that we can understand what makes escalation more likely and inform strategic nuclear decisions with this scholarship this is the aim of wargames as experiments strategy and unintended escalation wesue to understand how nuclear restraint could fail and lead to nuclear escalation wesue uses a geopolitical software as an experimental method to conduct causal research in the field of nuclear strategy a novelty this is an emerging field which would place wesue right at the cutting edge of research with a strong emphasis on nato and asia hence the choice of basing the operation of this research project in denmark at the centre for war studies cws at the university of southern denmark sdu wesue will offer a simplified version of a war game that can be played repeatedly easily and can isolatemechanisms through randomized treatment according to the doomsday clock we are less than two minutes to midnight
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strategies to prevent and reduce plastic packaging pollution from the food system
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stopp aims to stop the ways that lead to environmental pollution use of unsustainable virgin fossils excess use of resources high levels of generated plastic waste incineration and landfilling and climate change we aim to do this by producing strategies for circular food plastic packaging with refuse reduce redesign reuse and recycle approaches our goal is to enhance sustainable and circular use of plastic food packaging and decrease the amount of generated waste while reducing the environmental impact this is achieved via development and implementation of circular strategies together with an extensive network of plastics packaging value chain stakeholders and citizens and consumersincreased knowledge on the environmental and climate impacts of food packaging systems is a key driver in changing perception of reuse and recycling we will quantify the effect of littered plastic food packaging on the environment with analysis of different ecosystems biological organizational levels and key sentinel organisms this deeper understanding is an important part together with different stateoftheart and comprehensive enablers and barriers analysis for the technological developments business strategies and consumer studies done in the project our technological approaches for reuse focus on safe and highperformance material development improving return logistics and developing consumercentric communication strategies for recycling we will optimize collection systems create safe food contact polyolefin recyclates recycle biobased and smart food packaging and expand plastics recyclers europe recyclass certification scheme for recyclabilitystopp has a key role in supporting the packaging and packaging waste regulation implementation in its early stages via the developed novel solutions providing new open access knowledge and handson tools for the value chain actors to startup their sustainable circular food packaging journey as early adaptors
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exploring nonclassical states of centerofmass mechanical motion with superconducting magneto and levitomechanics
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supermeq addresses three basic science goals in quantum technologies targeting to gain new insights into quantum control over the centerofmass motion of mechanical resonators i we will push to the limits of decoherence mechanisms of massive objects ii we will maximize the vacuum coupling of the centerofmass motion of a mechanical resonator to a quantum system and iii we will generate useful nonclassical states such as squeezed states or states with a negative wigner function which have direct relevance for quantumenhanced force and inertial sensing our project follows a unique approach by realizing two complementary experimental platforms that are tailored to our goals and that are mutually beneficial through parallel development a magnetically levitated superconducting microparticles that access a mass regime spanning more than seven orders of magnitude between picogram and submilligram masses and that are expected to exhibit ultralow mechanical decoherence and b integrated clamped magnetic or superconducting mechanical resonators that are expected to reach strong vacuum coupling rates two orders of magnitude larger than the stateoftheart key in each of these approaches is that we will couple both types of mechanical resonator inductively to superconducting quantum circuits which allow for full quantum control over the centerofmass degree of freedom of the mechanical resonators our project results will lead to a breakthrough in the development and growth of novel quantum sensing technologies and give new insights into foundational aspects of quantum physics
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simulating electronic dynamics with quantum trajectories by combining exact factorization and density functional theory
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the quantum mechanical simulation of timedependent td phenomena is relevant for many technological and medical applications as in solar cells design control of radiation damage in biomolecules photocatalysis nanoscale conductance devices and quantum computerswith this proposal the candidate intends to overcome the most critical limitations of current methods for the calculation of electronic dynamics most notably of td density functional theory dft by pioneering a combination of 1 innovative density functional approximations and 2 an algorithm for timepropagation that treats one electron semiclassically the common thread linking these parts is the socalled exact factorization an overarching strategy that has been used by both the candidate and the supervisor in the contexts of dft and molecular dynamics md respectively according to this strategy the wavefunction is rewritten as a product of a marginal and a conditional amplitude and the corresponding schrödinger equation is conveniently expanded into two coupled equations providing a clear decomposition of the chemical environment joining together the candidates expertise in fundamental dft and the supervisors expertise in trajectorybased approaches the algorithm that will be developed takes inspiration from the method elaborated by the host for ab initio md simulations and adapts and supplements it in a way suitable to treat the motion of electrons the project includes validation of the algorithm on simple electronic structures simple atomsmolecules whose static and dynamical densities and potentials are computationally accessible and can serve as benchmark the end goal of the project is to develop a reliable and computationally practical method for the simulation of ultrafast processes that can support and complement the emergent experimental techniques attosecond spectroscopy particularly for those cases for which present tddft or alternative approaches fail
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innovative structural materials for fission and fusion
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innumat aims to develop innovative structural materials for nuclear applications and put them on track towards qualification for fission leadcooled and molten salt fast reactors as well as fusion demo high entropy alloys heas a new class of materials with a vast development potential and very promising properties as well as alumina forming austenitic afa steels already identified as prospective structural materials for gen iv and small modular reactors are in the main focus in which advanced material solutions are considered as well in particular weld overlay and coated 1515ti for leadcooled fast reactors among others myrrha and alfred and coated eurofer and advanced oxide dispersion strengthened ods steel for fusion demo some of these structural materials are of potential applicability also outside the nuclear field eg in concentrated solar power andor in h2 confinement the project is thus crosscutting because of the target applications as well as because of the accelerated methodologies for materials discovery screening and qualification that it pursues applied at different technology readiness levels trlsthe differences in trl application conditions and requirements of the considered materials result in different objectives and hence different research tracks through the project with even different efforts common goal is to rapidly increase the trl for the desired nuclear applications towards requirements of corrosion resistance high temperature strength thermal stability and irradiation tolerance which are not met by current structural materials therefore computational and experimental high throughput material screening methods will be applied and roadmaps for accelerated qualification will be established paving a fast way to more efficient safe sustainable nuclear energy systems with considerable contribution to the overall mission of developing economic energy systems with reducedzero co2 emissions
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hacking photosynthesis biosensors for herbicides and beyond
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the introduction of agrochemicals has drastically improved crop yields largely thanks to the use of herbicides that kill crop competing weeds unfortunately herbicides residues often find their way into our ecosystems drinking water and food current means to monitor herbicide residues utilize expensive timeconsuming methodologies such as liquid chromatography coupled to mass spectroscopy a technique typically restricted to first world countries and trained users a biosensor provides a means for rapid lowcost sensitive herbicide detection that is widely accessible even in developing countries i have previously evaluated a biosensing platform using an electrode coated with bacterial reaction centres but found that it was not sensitive enough to meet eu drinking water standards was limited to sensing a small class of herbicide residues and was not stable enough under storage for widespread distribution to tackle the issue of low stability i implemented a redox polymer transduction matrix resulting in biosensor stability for hours during operation and months in storage i then approached the most challenging aspect of boosting biosensor sensitivity by redesigning the biological recognition element itself using docking simulations to guide enzyme design that resulted in validated improvements in biosensor sensitivity in the lab this forms the platform for my research within the msca postdoctoral fellowship wherein i seek to push enzymeherbicide binding affinities to reach a biosensor sensitivity that meets eu standards expand the scope of sensing beyond a small class of residues and sense not just single but multiple herbicide residues on a single test strip the results of this work will lead to a herbicide biosensor that approaches market viability and lays the groundwork for a modular biosensing platform that can be extended beyond herbicides to include biomarkers for monitoring health and detecting disease
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teaching with money financial literacy in tuscan abacus manuals and merchants notebooks 12021478
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financial literacy is necessary to spend our money wisely and understand how financial instruments work in an increasingly complex financial landscape today only half of the eu adult population has an adequate understanding of basic financial concepts edumoney tackles this issue from a historical perspective to offer the first systematic comprehensive and digital analysis of the skills and knowledge underpinning financial literacy during another period of increasing financial complexity the medieval commercial revolution the focus is on money itself and how this was deployed and represented in tuscan abacus manuals and merchants notebooks the pedagogical tools of the time the project analyses the period between 1202 when fibonacci completed his liber abaci and 1478 when the first printed abacus manual known as aritmetica di treviso was published by adopting an interdisciplinary approach that combines methods from economic history medieval literature and the history of economic thought with the support of the latest digital platforms for text analysis i will digitise transcribe and translate a selected corpus of abacus manuals and merchants notebooks this will allow a comparative and digital study of these sources to identify crossreferences to money that will be grouped into typological families the resulting categorisation will form the basis for an indepth analysis leading to an innovative treatment of money as a heuristic and pedagogical instrument and to a more holistic understanding of how people lived learnt and conceptualised their lives as economic actors the enhancement of financial literacy among different age groups through a series of didactic and outreach activities will empower people by endowing them with the right tools to make informed decisions to improve their economic wellbeing thus tackling social and gender inequalities for the development of a more inclusive europe
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development of brainpermeable masked nanobodydrug conjugates to eliminate glioma stem cells
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glioblastoma multiforme gbm is one of the most prevalent brain tumours and is currently incurable patients die from tumour recurrence after resection and chemotherapy new treatments need to overcome two great challenges reaching the tumour margins where the bloodbrain barrier bbb is intact and eradicating glioma stem cells gscs which cause tumour relapse targeting receptors overexpressed on cancer cells with antibodydrug conjugates adc has shown great promise in cancer treatment however most receptors on gscs are also present in normal stem cells thus targeting these receptors with antibodydrug conjugates may lead to severe side effects the main objective of this proposal is to develop a masked nanobodydrug conjugate with the capacity to overcome the bbb and to be activated only in the tumour to selectively target gscs nanobodies have increased capacity to penetrate tissues and biological barriers but none is yet available to target the gsc marker cd133 therefore i will generate new nanobodies against this receptor subsequently i will set up a phage display platform to develop masked nanobodies that can be selectively unmasked by tumour proteases the masked nanobody will be conjugated to a drug and then to a bbbshuttle peptide a panel of conjugates will be screened in vitro for target selectivity efficient activation and bbb transport finally the efficacy of the most promising candidates will be tested in a gbm mouse model our unique combination will generate the first bispecific nanobodydrug conjugates targeting gscs to treat gbm the concept of gsctargeting with activatable adc may change the current paradigm for the treatment of brain tumours furthermore our workflow may be applied to dramatically enhance the efficacy of other biotherapeutics with ontarget offsite doselimiting effects
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unraveling the link between microbial biogeochemical cycles and mercury transformations in oxygendepleted submarine groundwater discharges
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coastal aquifers are sensitive landocean transitional zones receiving nutrientrich water due mainly to fertilizing practices that may increase microbial activity and reduce oxygen o2 availability the diverse microbial communities inhabiting these systems may have a crucial role in biogeochemical cycles including metal transformations such as mercury hg yet the factors determining the microbial hg transformations in coastal aquifers is poorly understood the increasing depletion of o2 in coastal waters from submarine groundwater discharges sgds may modify the biogeochemical processes and hence modulates the hg speciation and its export to the sea to shed light on this the mimoa project aims at defining the role of nutrientenriched sgds in microbial hg cycling of coastal areas by combining microbial chemical and educative dimensions this project will rely on the synergy of my background in biogeochemical cycles and anoxic environments with extensive expertise in hg biogeochemistry and metagenomics of the host dr bravo this will be complemented by the essential expertise in biochemistry of low o2 zones and analyticenvironmental chemistry of the two secondment supervisors dr garciarobledo and dr amouroux by getting trained in bioinformatic analyses gene detection and chemistry i will explore the effects of o2 depletion from sgds on microbial hg transformations in an eutrophication context and transfer this knowledge to the general audience through science outreach and education assisted by plncton company as a placement mimoa outcomes will significantly contribute to global hg budget by revealing the importance of hg export through depleted o2 sgds having longterm consequences on marine food web contamination and improve awareness of general audience on their anthropic footprint in coastal zone boosting my career opportunities as a prominent researcher in microbial ecology and biogeochemistry after my research period in latin america
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development of a global diagnostic ecosystem for detecting and monitoring emergencyprone pathogens across species and in a unified way
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we aim to contribute to global diagnostics and preparedness for the next health crisis by developing in vitro diagnostic devices and methodologies for application at the pointofcare for this purpose mature as well as novel technologies and assays will be developed addressing all pandemic preparedness requirements ie with regards to assay characteristics and ability to assimilate new targets as well as platform ease of use and connectivity fulfilling manufacturing and regulatory requirements in the 36 months of the project we intend to develop and deliver two ivdr certified devices and six molecular assays for emerging pathogens detection at the pointofcare we will build on a recent commercial success during the covid19 pandemic the pebble platform and an innovative pocketsize device to be developed within the project both providing capability for connectivity and surveillance for the rnatargets detection we will employ a recently developed amplification method damp demonstrated to have a high specificity in crude samples three broad assays will be developed for screening of viruses belonging in one of the families of corona influenza or arboviruses and three specific ones for dengue zika and west nile viruses all according to ivdrrecommendations importantly the above six assays will be tested using samples from humans animals and during fieldmonitoring of mosquito populations providing a solution for the one health initiative for the development of accessible diagnostic tools the unihealth consortium consist of expert researchers technologists doctors social scientists regulators innovators and biomedical device providers within the areas of diagnostics and pandemics the high degree of unihealths innovation and the codevelopment of solutions with global partners and endusers will expand the visibly and uptake of the project results to a global level leading to a high preparedness and an economic and social success
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freespace optical communications for aerialsatellite networks
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with currently 3 billion people lacking access to broadband internet worldwide european operators are struggling to fill the white areas with insufficient or nonexistent connectivity in light of the early promises of 6g wireless networks it is tempting to consider nonterrestrial networks as complementary to the groundbased radio and fiber infrastructure however radio frequencybased satellite systems are nearing their capacity limits and cannot be scaled further freespace optical technology is a natural alternative to deliver greater capacity and to better address data security needs by leveraging quantum communications the first optical intersatellite links are being deployed in commercial networks at relatively low data rate 10 gbps however once the most important remaining research challenges are resolved they could rapidly expand and serve as a catalyst for the development of a new communication backbone in the sky consisting of aerial and space optical nodes at different altitudes the overarching aim of the focal project is to train a new generation of highly qualified doctoral candidates in developing innovative aerial and space optical wireless technologies that will provide future telecommunication networks with ubiquitous connectivity resilience and quantumproof security in addition to contributing to the fundamental understanding and technical knowhow of such networks through cosupervised individual research projects focal will train talented and innovative researchers with multidisciplinary expertise and skills that are desirable in this european industrial sector this will be achieved through a combination of theoretical and handson research training provided by a unique consortium of 16 academic and 10 industrial partners from 8 countries resulting in collaborative research including cosupervision and secondments as well as transferable training skills which is necessary for prosperous careers in this prominent ri area
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novel fuelflexible ultralow emissions combustion systems for sustainable aviation
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improving local air quality at airports while at the same time decarbonising aviation can be achieved by switching to sustainable aviation fuels safs and hydrogen h2 as confirmed by recent engine development programs however both these fuels require significant developments in the gasturbine combustor because present technologies not only to further reduce nox and pm emissions as expected by longterm standards and objectives but also are not normally suitable for 100 direct combustion of hydrogen in this project revolutionary combustor architectures will be studied extending the preliminary results of previous clean sky 2 innovative nox reduction technologies projects in terms of scientific scope and trl in particular this project will advance i the lean azimuthal flame leafinnox a novel combustion system based on flameless oxidation ii the compact helically arranged combustor chairlift a new system which uses interacting lean lifted flames and iii plasma and electric manipulation of the spray and of the flame stabilisation mechanism the fuel flexibility offered by these novel concepts is key to allow for saf and h2 operations this unique feature will be exploited to give novel dualfuel lto cycle strategies and ultralow nox ultralow soot single or dualfuel use experiments on available dedicated rigs and numerical work will be performed to provide knowledge at the fundamental and practical level that will allow trl3 and higher developments at the end of the project the project will include new cfd loworder and ai models and novel stabilisation techniques ripe for commercial exploitation
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seeing stuff perceiving materials and their properties
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different materials such as silk soil steel and soap exhibit an astonishing variety of physical properties appearances and behaviours the material properties of objects and substances are central to practically every task we perform from selecting and preparing food to detecting slippery ground to using tools effectively without touching a surface we usually enjoy a vivid impression of what it would feel like through the sense of sight yet how we do so remains mysterious decades of research has focussed on the visual recognition of objects faces and scenes by comparison how we see think about and interact with stuff has been relatively neglected stuff addresses this major gap in our understanding material perception poses unique and fascinating challenges the image of a surface is a complex and ambiguous combination of lighting shape and material properties how does the visual system disentangle these intermingled physical factors deformable materials like liquids and textiles move and change shape in complex yet lawful ways how do we infer intrinsic properties like viscosity compliance and elasticity from such everchanging stimuli and how do we reason about and predict their future behaviours as they interact with their surroundings how do we adapt our own interactions with objects to take into consideration their hardness density friction and other physical characteristics allowing us to pluck a raspberry without crushing it or pick up wet soap without it slipping through our fingersstuff takes a radically interdisciplinary approach to these questions in five tightly interconnected workpackages bringing together stateoftheart methods from experimental psychology and behavioural neuroscience computer graphics and computational image analysis machine learning and even art we draw on real and simulated materials to uncover how we perceive reason about predict and interact with materials and their properties
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dietwise systemic solutions to enhance healthy and sustainable food provision and cooking at home
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the dietwise advances the stateoftheart by proposing systemic changes a focus on inclusion and open social innovations with the aim of developing solutions that streamline existing tools and applications to foster healthy and sustainable food provision and to make cooking eating and treating of food at home the most attractive choice for all stakeholders using disruptive new approaches and voluntary market selfregulation our activities will help to dampen nutritional noise gradually and organically merge cultural and commercial practices with a healthier and sustainable food consumption pattern next we will empower citizens with novel citizen sciencebased solutions that will shift the role citizens play away from passive actors influenced by the food environment to citizens as active participants influencing their decisions and helping to create better digital food environments the project will generate multiple novel insights to empower citizens to make healthy and sustainable choices and original empirical evidence through big data analysis largescale surveys qualitative research and microlevel experiments from a methodological point of view we will harness novel state of the art methods such as using artificial intelligence ai algorithms with deep learning techniques to analyze big online data finally we will integrate scientific and empirical findings into social innovations powered by ai and develop useroriented tools to support citizens as a result our methodological and empirical advancements will provide a deeper understanding of how various external systemlevel environmental factors shape attitudes and beliefs towards healthy and sustainable food provision and cooking how to motivate consumers to follow nutrition guidelines how to include the ones who are in greatest need and how to help citizens shape digital food environments
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fostering capacity building for civic resilience and participation dialogic communication ethics and accountability
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digital communication enormously expands the number of ways people can interact and engage but also challenges european societies by spread of conflict instigation hate speech and increasing amount of disinformation the many initiators of destructive communication acts are various actors with diverse interests who are not bound by either professional or ethical rules or obligations to distribute truthful information or stand for its reliability the existing framework of public communication does not empower citizens to influence the ways the media institutions and actors operate in european democraciesdiacomet contributes to the advancement of ethical and accountable communication by fostering capacity building for civic resilience against information distortions and promoting civic accountability therefore diacomet aims to generate a concept of dialogic communication ethics dce which would provide a framework for an inclusive model of accountability mechanisms that combine media accountability the level of organisations with civic accountability the level of citizens and is guided by a civic code of good communication conduct cgc a new type of code of communication ethicsthe diacomet proposal explicitly addresses the aims of the horizon europe culture creativity and inclusive society work programme the topic the call and the european democracy action plan through1 analysis of the role of dialogic communication in existing ethics codes and guidelines and formulation of the cgc2 a novel concept of inclusive civic accountability bodies and a tested accountability mechanism3 an interactive dilemma game and a forum for learning and discussiondiacomet proposes to establish a european network of civic accountability bodies for supporting individuals groups and organizations to implement the cgc and to assist in managing ethical issues emerging in public communication
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a landscape approach to cultural heritage management in the context of climate change
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this proposal addresses cultural heritage conservation and management in the context of climate change it goes beyond the traditional differentiation between tangible and intangible heritage and addresses the city as a living heritage accordingly it seeks to develop a landscape peoplecentered methodological framework that acknowledges the active role of communities in coproducing local knowledge the proposed framework integrates different perspectives from different disciplines noting the scientific social and humanities approaches along with cultural and natural heritage perspectives as a result it is structured around several axes to address physical settings landscape perceptions cultural values digital heritage practices and vulnerability of cultural heritage to climate change to address the complex nature of cultural heritage the proposed method incorporates social media metadata and traditional data sources and integrates qualitative quantitative geographical and visual analysis along with machine learning techniques by doing so it seeks to map how different stakeholder groups value heritage in the context of climate change and assess the vulnerability of heritage and its associated values to climate change the novel aspect of this proposal is the use of digital technologies to engage local communities in heritage values assessment and heritage management recommendations to foster a sense of communal ownership in the local heritage landscape from the grassroots level the innovation of this project lies in linking physical vulnerability and risk management concepts with a more general and multidimensional resilience approach focused on the singularities of cultural heritage resilience results are expected to draw recommendations for integrating policies and practices of heritage management sustainable urban development and climate governance
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track and forecast changes in marine fish population stability over time and across space
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marine ecosystems provide key functions and services including biodiversity and food resources disturbances such as climate change and overfishing are seriously threatening the future provision of these services and leading to collapse of marine populations to track and forecast marine ecosystem stability has emerged as a new paradigm to understand the capacity of an ecosystem to persist a qualitatively similar state in the face of disturbances however three challenges prevent the advances in this research field most established stability measures assume stable equilibrium and constant magnitude of disturbances while marine ecosystems are influenced by multiple disturbances simultaneously with the magnitude of disturbances changing with time in addition even though population stability varies with space most of existing work examined marine ecosystem stability at the regional scale of fishing grounds due to limitations in data and methodology moreover age group interactions fundamentally affect population dynamics yet have been overlooked when quantifying population stability in line with those reflections this proposed research intends to develop a novel research framework to track and forecast marine population stability encompassing temporal and spatial dimensions of three key fish species of the north sea wp1 and to identify drivers of population stability across space wp2 empirical dynamic modelling will be used to track and forecast the evolution of population stability over time and across space based on age group interactions of the population producing yearly population stability maps from 1977 to 2022 and forecast maps from 2023 onward these results will be transformed into webbased interactive map and manual wp3 for fisheries managers and researchers to identify the most vulnerable locations in the fishing grounds and to decide fishing quota with the overall goal of preserving stability in marine ecosystems
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resolving ambiguities in flow boiling within micropassages integrated modeling and experiments
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electronic products are progressively smaller and more powerful resulting to an exponential increase in the generated residual heat their effective and environmentalfriendly cooling is therefore of upmost importance for many applications such as data centres fuel cells insulatedgate bipolar transistors lithiumion batteries and photovoltaic cells with a market value of several billions of dollars worldwide flow boiling within micropassages has been proven as one of the most efficient cooling strategies for such highpower density electronics however such solutions are not yet commercially available this is due to a lack of a deep understanding of the underpinned flow and transport processes and unresolved ambiguities in microscales and hence of reliable and easytouse thermal design tools for smallscale components refine aims to give light at such crucial ambiguities utilising a synergic combination of novel volume of fluid vof based numerical simulations and tailored highresolution experimental diagnostics dr andredaki will develop a novel cuttingedge simulation tool starting from an already enhanced vof solver that she has been developing in the last years this will be validated against parallel advanced experimental measurements on flow boiling that she will perform using single and multiple parallel microchannel heat sinks the final optimised and validated numerical solver will then be applied for a wide series of parametric simulations that in combination with additional laboratory measurements will form a unique database that will lead to the development of novel physicsbased design correlations for flow boiling microchannel heat sinks the wordleading expertise of prof moreira who will supervise this project on the experimental techniques for microscale boiling guarantees the highest level of knowledge transfer enabling dr andredaki to further develop her skills and enhance her future career opportunities in academia
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awareness and resilience through european multi sensor system
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public awareness to environmental risk is key for building resilient societies artemis will develop a smart sensor system monitoring radon temperature acidity and other observables in groundwater in real time the groundbreaking sensor design will assure affordability resilience and low power consumption optimizing life cycle management the project aims to produce 100200 sensors that will be deployed in sensitive sites in collaboration with municipalities changes in radon concentration have the potential to serve as precursor for earthquakes and volcano eruptions to advance our knowledge in this field we propose the development of a cheap sensor system that can be employed on a large scale in earthquake prone areas of europe the real time collected data is used to build machine learning ml models for the analysis the collected and ai processed data will generate a real time map of hydrological and geochemical changes that is shared to the scientific community and public bodies engaged in the project a pilot project engaging citizens of the participating municipalities is part of the dissemination and exploitation activities we expect artemis to clarify the longstanding issue of earthquake predictions by means of geochemical precursors like changes in radon concentration the system is designed for scalability dissemination and exploitation activities are tailormade to ensure support and expansion of artemis after the projects completion radon content in water causes health issues and artemis offers a novel way to monitor both content of radon as well as changes in real time that may indicate changes in flow pattern hence artemis is facilitating multipurpose use of the sensor system the project will result in a shift of paradigm for environmental monitoring and natural hazards and in this fashion render europe a leading role in environmental monitoring
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quick challengedriven humancentered cocreation mechanism for industryacademia collaborations
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indusacs main objective is to develop and validate a stateoftheart industry academia collaboration iac mechanism for quick challengedriven humancentred cocreation its aim is to build upon preexisting iac mechanisms such as eit kics and to facilitate a simple userfriendly cocreation process that allows to develop solutions that clearly address the needs and interests of companies students and researchers in the eu with special attention to widening and associated countries of a highly digitalised nature our project will pilot the mechanisms two main components a methodology developed by applying humancentred design principles and an online platform aimed at connecting stakeholders from the industryacademia ecosystem and at supporting them throughout their cocreation journey the indusac methodology will provide the guidance and tools needed to power the process whilst the platform will stand as a networking space for stakeholders to connect as well as a cocreation arena to develop joint solutions through the experience of supporting at least 300 transnational cocreation teams throughout project lifetime the indusac mechanism and its two key components will be successively improved until project end delivering a tested mechanism ready for replication and upskilling it is expected for indusac to also create a dynamic community of industryacademia stakeholders including at least 1000 companies 3000 students and 300 researchers by project end the indusac counts with a strong interdisciplinary crosssectorial and geographically balanced partnership that counts with the needed expertise and network to achieve our projects goals
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uncovering the mechanisms of action of an antiviral bacterium
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animals and microbes interact in intricate ways wolbachia a common intracellular insect symbiont can manipulate reproduction and protect hosts from viruses thus wolbachia is an asset in the control of insectborne diseases however as wolbachia cannot be cultured outside of host cells or genetically manipulated the mechanisms of its antiviral phenotype remain poorly understood and this inhibits wider exploitationi have been working to remedy these deficiencies and now stand poised to discover the mechanisms of wolbachiaconferred antiviral protection by answering the following questions1 where does the protection originate up to now mechanisms of protection have been studied in whole organisms often lacking resolution or in cultured cells which lack emergent properties i will identify tissues and cell types of the host where protection starts to do this i will a quantify titers of wolbachia and virus at early time points postviral infection in insect tissues b measure gene expression of host and microbes to identify candidates for further molecular characterisation and c test the extent of the utility of widely adopted yet unvalidated cellculture models of antiviral protection2 which wolbachia genes effect protection wolbachia research has historically been impeded by a lack of tools to study gene function here i will deploy antisense technology which i have recently developed to interrogate function of candidate wolbachia genes in the native system i will also engineer new methods to target wolbachia genes and proteins based on my data on cellpenetrating peptidemediated delivery of bioactive cargo to wolbachiathis project has two major outcomes it will uncover wolbachia factors responsible for wolbachiaconferred antiviral protection and it will transform wolbachia and symbiosis research by creating tools to study symbiont gene function
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autonomous selfadaptive services for transformational personalized inclusiveness and resilience in mobility
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the autotrust project aims to develop and demonstrate a novel aileveraged selfadaptive framework of advanced vehicle technologies and solutions which optimize usability perception and experience onboard and when boardingoffboarding in terms of security privacy wellbeing health and assistance autotrust provides enhanced inclusiveness and trust in the interaction between users and new automated modes of road transport and mobility services in the transition from humandriven to automated vehicles safety and security of vehicle occupants in all circumstances even when the vehicle is driverless by helping to prevent dangerous and inconvenient situations will be of paramount importance intense cooperation between users vehicle manufacturers suppliers researchers and other stakeholders to codesign vehicles with solutions that optimize the onboard experience will be adopted moreover an indepth knowledge of the benefits of new vehicle technologies and solutions in terms of onboard experience accessibility inclusiveness and trust will be acquired to enable wider user acceptability and contribute to the creation of future standards
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conciseness of words in residually finite and profinite groups
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the notion of conciseness of words in groups was introduced by phillip hall at the beginning of the second half of the past century hall conjectured that every word is concise in the class of all groups but this was proved to be false in 1989 by ivanov in its general form however the question whether every word is concise in the class of residually finite groups raised by andrei jaikinzapirain is still open and is currently the main conjecture in the topicin recent years the notion of strong conciseness in profinite groups has also been introduced and in this context an analogous conjecture has been proposed namely that every word is strongly concise in the class of all profinite groupsthis proposal is thus devoted to the study of conciseness and strong conciseness of words as well as some related notions in residually finite and profinite groups for the purpose of getting closer to the proofs of the aforementioned conjectures we suggest a multidisciplinary approach by combining group theoretical topological and measure theoretical methods for instance we propose studying conciseness and strong conciseness of words in certain classes of prop groups such as padic analytic prop groups or introducing the notion of hausdorff conciseness by relating the hausdorff dimension of the set of word values with the hausdorff dimension of the verbal subgroupthis project proposal is a natural continuation of the applicants research career who has already worked in several wordrelated problems and will highly contribute to strengthening the candidates research skills as well as to bringing novel and interesting ideas to the host organisations
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inoperando growth of organic mixed ionicelectronic conductors for braininspired electronics
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the development of advanced braincomputer interfaces wearable and implantable bioelectronic devices prosthetics and soft robotics requires the ability to process signals in a highly individualized and localized manner to achieve this new materials and devices must be developed that can sense their surroundings process information locally and translate it into a format our body can interpret currently bioelectronic devices rely on remote and energyintensive cloud processing but electronic devices that mimic the design of the human brain offer a solution however siliconbased devices have limitations such as rigidity poor biocompatibility and operating principles that differ from the ion signal modulation of biology organic mixed ionicelectronic conductors omiecs have emerged as a promising option in the field of bioelectronics as they are solution processable potentially biocompatible and can transport both electronic and ionic signalsthe goal of infer is to create nextgeneration intelligent bioelectronic devices using inoperando electropolymerization of omiec monomers the proposed research activities aim to 1 understand how the molecular properties of omiec monomers impact their inoperando electropolymerization and the learning capabilities of the resulting biomimetic devices 2 achieve biorealistic speeds memory functionalities and energy efficiencies without the use of auxiliary devices and 3 prototype devices that can locally sense process and actuatestimulate the longterm goal is to create a braininspired intelligent bioelectronic platform that brings a new paradigm for insensor computing at the interface with biology
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reaction mechanism of methanol conversion in zeolite by integrated diffusionreaction kinetics model
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c1 chemistry plays a crucial role in providing energy and chemical supplies while meeting environmental requirements such as carbon neutrality to mitigate global warming and the gradual shift in the supply chain from crude oil to biomass and other alternative carbon sources zeolites as one kind of important heterogeneous catalysts create a perfect environment to selectively and effectively convert c1 molecules to chemicals with high economic value as for instance the transformation of methanol to olefins mto or the methanol carbonylation process however the understanding of the reaction mechanisms of these methanol conversions in zeolites is lacking up till now the diffusion process of reactants intermediates and products in the confined spaces of zeolites has not been considered in the free energy landscape of the catalytic cycle which leads to a discrepancy between experiments and calculations therefore the proposed integrated diffusionreaction kinetics model is an essential keystone to understand the high selectivity of zeolites in c1 chemistry in this project ab initio molecular dynamic aimd simulations accelerated with different enhanced sampling methods will be employed to study the complete kinetics of methanol conversion in zeolites including the processes of reactants adsorptiondiffusion reaction and product diffusiondesorption this should result in a complete free energy landscape by which the parameters of zeolites that influence the selectivity of c1 chemistry will be uncovered the final affinity of this model is to guide the modification design and screening of highly effective zeolite catalysts for c1 chemistry in an efficient and adequate manner
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new multisensory technology for early intervention in infants with visual impairment
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visual impairments are disastrous for infants they affect the infants reaching and motor skills space perception playing socializing physical functioning psychological wellbeing and health service needs therefore early therapeutic interventions aimed explicitly at fostering these abilities are needed to improve the quality of life of people with visual disabilities effective rehabilitation technologies to enhance visually impaired infants skills depend critically on a better understanding of the neuroscientific bases of multisensory and body processing however to date these abilities can only be assessed qualitatively based on observational approaches due to the complexity of conveying a signal to visuallyimpaired infants that they will assuredly understand technological solutions providing a quantitative output for visuallyimpaired infants are unavailable with ireach we aim to solve this problem specifically we will design develop and propose for commercialization a multisensory system that will provide noninvasive recording and training of the sensorymotor skills in visuallyimpaired infants it will be compatible with simultaneous measures of behavioral and brain activity responses eg electroencephalography this technology will be designed based on realizing four concomitant tasks 1 development of a novel rehabilitation technology conveying multisensory and bodily stimulation 2 development of a quantitative method that will train and measure visuallyimpaired infants sensorymotor responses 3 development of sensorymotor paradigms providing the audio and tactile spatial stimulations associated with body movements 4 dedicated pipelines to analyze infants response to multisensory stimulations and with regard to body position for the first time the product resulting from ireach will train and directly quantify visuallyimpaired infants sensorymotor abilities offering a costefficient system for early intervention
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global estimates for nonlinear stochastic pdes
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the project is concerned with the global behaviour of solutions to stochastic partial differential equations spdes from mathematical physics which arise eg in the description of scaling limits of interacting particle systems and in the analysis of quantum field theories the equations contain noise terms which describe random fluctuations and act on all length scales in this situation the presence of a nonlinear term can lead to divergencies a subtle renormalisation procedure which amounts to removing infinite terms is needed over the last years the understanding of nonlinear spdes has been revolutionised and a systematic treatment of the renormalisation procedure has been achieved this led to a shorttime wellposedness theory on compact domains for a large class of highly relevant semilinear spdes in this project i will describe the global both in time and over infinite domains behaviour of solutions of some of the most prominent examples by combining pde techniques for the nonlinear equations without noise and the improved understanding of the subtle smallscale stochastic cancellations i have already pioneered such a programme in an important special case the dynamic phi4 model the project has three specific strands a proving estimates for the stochastic quantisation equations of the sinegordon and liouville quantum gravity models and eventually gauge theories and to giving a pdebased approach to the celebrated 123 scaling of the kpz equation b giving pdebased constructions of phi4 models in fractional dimension and describing phase transitions in terms of mixing properties of the dynamics c treating degenerate parabolic equations and exploring if systems that fail to satisfy a fundamental subcriticality scaling assumption can still be treated using spde techniques
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thermodynamicsdriven control management of hydrogen powered and electrified propulsion for aviation
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in order to mitigate the negative impact of human activity on the environment significant efforts to lower carbon emissions are being pursued at both the global and european levels globally the aviation industry aims for a 50 reduction of its carbon emissions by 2050 relative to 2005 in this transition towards net zero carbon emissions novel powertrain technologies exploiting fuel cells andor combustion systems that rely on hydrogen will play a significant role triathlon will use the synergy between powertrain components to overcome the challenges associated with scaling up hydrogen powertrain technology to mw class the ambition of triathlon is the development of disruptive approaches to design more robust lowmaintenance lowemmision highly responsive hydrogenelectric powertrains for megawatt class aircraft when the distruptive technologies developed by triathlon are adopted by the industry beyond triathlon it will lead to 1reduction of emissions by implementation of nox reduction strategies like injection of exhaust water of the fc into the cc and by capturing vented and permeated hydrogen and recompressing it2elimination of the need for a cryogenic pump by using a highpressure storage buffer for pressurisation of the fuel distribution system making the fuel distribution more robust for turbulence as well3reduction of the power required for hydrogen conditioning using excess heat from fc and cc by means of 3d printed heat exchangers using innovative materials like ceramics and smart thermal management4improvement of the gravimetric index of the entire powertrain by providing an effective heatsink to powertrain components reducing the need for coolant allowing design of a more compact and lightweight cc as well as the need for insulation of the hydrogen storage whilst enabling a longer dormancy time
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edge multi sensing for medical and pharma applications
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ezmems provides determination a smart disposable multisensor that transform simple medical or pharma products infusion lines fittings plastic bags bioreactor transportation line into smart products in an easy and costeffective way the multisensor is noninvasive has low footprint and provides robust multi sensing pressure flow temperature conductivity viscosity turbidity and ph and fully wireless connectivity no battery no wires energy harvesting at the edge making internet of medical things possible ezmems multisensor technology is based on advanced polymeric multilayered matrix composite structure integrating conductive piezoresistive structural elements each layer implements a specific function mechanical layers sensing layer interconnection layer and integration layer the integration layer can be modified according to the application requirements to the polymer of the product determination can be fabricated in mass production facilities
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support to resaver pension fund horizon europe horizon europe work programme 20212022
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the resaver pension fund is a special multicountry crossborder occupational pension vehicle contributing to the removal of the obstacles of researchers mobility in europe through enabling mobile employees of research institutions to remain affiliated to the samesupplementary pension fund when moving between different countries and changing jobsthe resaver pension fund stands for free movement of workers as a fundamental principle of the treaty enshrined in article 45 of the treaty on the functioning of the european union and wants to create a future in which employees researchers specifically can move and work in eu without any additional difficulties related to accumulation of occupational and personal pension provisionsthe overall aim of the establishment of the resaver pension fund corresponds to the strategic objectives of the european union on the creation of the european research area to enhance the competitiveness of a knowledgebased europe the more research institutions jointhe resaver pension fund the more effective it will be in removing pensions as a barrier to the mobility of researchers in europe and the more it will fulfil its purpose of supporting the creation of a european research areathe general objective of the resaver pension fund is to continue expanding its membership in all countries of the european economic area and support the third fiscal year of its core operations while the fund grows specifically this means to ensure that the service providers carry out their roles effectively and deliver a smoothly operating pension process to finance the fees essential for the ongoing running of the resaver pension fund to ensure that the pension fund has the capacity to enroll new potential organisationsthe resaver pension fund was established in belgium and received its authorisation to operate from the belgian regulator fsma on october 28 2016
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identifying and developing adaptive skills for facing transformation
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this groundbreaking solution in the field of skills development enables for the first time a qualitative analysis of softskills and optimise its development rising up provides an integrated software solution called the lab for identifying anddeveloping the soft coreskills that are needed to access the job market
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heritage for the future science for heritage
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the proposal consists in organising a european conference on heritage science entitled heritage for the future science for heritage a european adventure for research and innovation it is organised by the fondation des sciences du patrimoine fsp in partnership with the french ministry of culture and the french national centre for scientific research cnrs as part of the french presidency of the council of the european union that will take place during the first semester of 2022the conference aims to bring heritage science to the forefront to highlight its diversity and gain recognition of its central role to address major contemporary challenges at national and european level as well as its articulation with the main european initiatives in line with this mission the conference will illustrate how cultural heritage research can concretely support a more inclusive innovative and sustainable europe i it also aims to increase the visibility and promote the efficiency of the various disciplines and ecosystems involved in better identification understanding preservation restoration and transmission of cultural heritage may it be tangible intangible digital or natural ii finally it will identify challenges and discuss prospects for heritage science in the face of current societal changes iiithese objectives will be achieved through an ambitious conference programme and various presentation and discussion formats bringing together different stakeholders involved in the production valorisation dissemination and implementation of heritage science knowledge the conference will also produce a wide range of outputs that will contribute to spread the content and key messages of the discussions towards a wide european and international audience
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greendemo
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greendemo sets out to study the new and innovative role of public administrations in coping with societal challenges particularly in supporting democratic processes of societal change to reach green sustainability goals the project aims to contribute to greener democracies in europe and to more democratic sustainability transition processes greendemo more particularly proposes to design prototype test and replicate organisational innovation in city administration in order to enable stabilise and enhance capacities of public administration to act for climate neutrality and democratic stabilitycity administrations need to collaborate with stakeholders to set up local green deals this is critical given that trust in public institutions is weakening crisis of democracies moreover even in a less challenging political climate establishing effective political interventions in support of ambitious climate and green sustainability goals is a complex issue thus there is a double pressure on democracies to secure effectiveness and democratic legitimacy current studies suggest that this requires public administration to build up transformative capacities one lever to build such capacities is organisational innovation eg new structures or processes or practices demo cities mannheim bristol aalborg commit to such organisational innovation and will work on demonstrators while fellow cities glasgow aarhus bamberg schaerbeek poznan will work on replication activities and roadmaps for their own organisational change process we assume that cities which prove to be able to innovate their approaches and work together with their stakeholders will be in a better position to implement effective local green deals this in turn is expected to increase trust in public bodies and hence might be an important mechanism to strengthen democracies
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artificial intelligence and sensorfusion systems in sustainable green robotics for precision agriculture
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aigreenbots is a msca doctoral network that will implement interandcross multidisciplinary training career development and research collaborations for 11 researchers ie dcs doctoral candidates by an international and complementary partnership involving top universities research institutions agriculturerelated stakeholders living lab and robotic farm infrastructures and companies from different countries pt nl uk fr es to provide tomorrows talent with the skills and knowledge to tackle one of the major challenges of our society and the environment agricultural robotics for precisiondigital agriculture by engaging the dcs on a researchtoindustrial exploitation paradigm the aigreenbots doctorallevel training brings together academic and nonacademic participants from different areas robotics automation remote sensing for precision agriculture reliable artificial intelligence ai and probabilistic machine learning systems engineering probabilistic inference sensor fusion safety and realdeployment of agricultural robotics collectively aigreenbots will work with the researchers to develop new agribots platforms wp3 robotic perception and sensorfusion systems wp4 reliable machine learning wp5 decisionmaking under uncertainty wp6 safety and important legislation aspects will be learned as well wp7 currently europewide there are no phd training programs that focus on agriculturerobotics that expose students to such broad concepts and expertise yet there is a rapidly growing need for that research after completion of the project researchers will be fully capable of driving interdisciplinary research at the international level thus aigreenbotss structure will serve as a european platform for outstanding doctoral training in intelligent robotics for precisionautomated agriculture and digital farming
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autonomous robots with common sense
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autonomous robots such as autonomous vehicles cars and drones have the potential to revolutionize the way we work and live unfortunately current autonomous robots do not have common sense and may enter a catastrophic condition called lossofcontrol after failures the ultimate goal of this research is to enable a new generation of autonomous robots that are aware of their physical capabilities and limitations allowing them to act with common sense after failures to achieve this i propose a new paradigm in autonomous robot control artificial physical awareness apa apa requires accurate realtime knowledge of the timevarying stochastic safe envelope which is a subset of the statespace inside which safe operations of the autonomous robot can be guaranteed the safe envelope is stochastic and timevarying it contains uncertainties and will shrink after failures reflecting the reduced postfailure performance of the autonomous robotobtaining and utilizing the timevarying stochastic safe envelope in realtime represents a currently unsolved scientific challenge for the following reasons 1 the safe envelope cannot be measured directly 2 current safe envelope computation methods are realtime intractable andor do not take into account uncertainties and 3 no control methodology exists that allows for timevarying safeenvelope informed balancing of safety and performancethis multidisciplinary research combines new insights in timevarying stochastic state reachability analysis tippingpoint forecasting bioinspired envelope sensing and recovery and nonlinear faulttolerant control to develop the new apaautopilot system which is the main output of this research this research project has the potential to lead to a revolution in autonomous robot design and operations by providing transparent safety and performance bounds even after failures
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spatiotemporal shaping of electron wavepackets for timedomain electron holography
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advanced techniques of electron microscopy and spectroscopy require tools which enable to control various degrees of freedom of electron beams phase profile temporal structure orbital angular momentum etc the inelastic quantum coherent interaction between light waves and electron wavepackets allows to structure the temporal probability distribution of electrons with attosecond precision which may enable probing the coherent dynamics of optical excitations or plasmonic nearfields of nanostructures and metamaterials up to now only electronphoton interactions mediated by solidstate structures have been considered which have severe limitations in this project i will develop a versatile tool for quantum coherent shaping and full characterisation of the phase profile and amplitude of the electron wave function in electron microscopes the interaction will be mediated by the ponderomotive potential of spatiotemporally shaped light fields in vacuum the electron wavepackets will be controlled on nanometer spatial and subfemtosecond time scales that are natural for light waves the optical coherence imprinted to the electron wavepackets will be exploited in two ways i i will explore the possibility to transfer the temporal coherence from densitymodulated electron wavepackets to radiation and bound electron excitations in twolevel quantum systems by detecting phaseresolved cathodoluminescence and coherent smithpurcell radiation driven by swift electrons ii i will introduce timedomain electron holography which will exploit the temporal coherence of shaped electron wavepackets for phaseresolved imaging of optical excitations in nanostructures the approaches proposed in this project open new pathways for electronmediated optical quantumcoherent control and spectroscopy with atomic spatial resolution
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intrahousehold responsibilities and financial decisions
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much of todays policies addressing poors welfare are based on the presumption that women are more likely than men to use income in ways that improve household welfare an approach of predominantly targeting women however may overlook opportunities from how men could be encouraged to contribute more to the household welfare i develop a framework that joins empirical and theoretical findings on intrahousehold allocations and gender norms in developing countries by incorporating the role of intrahousehold responsibilities in spouses financial decisions i use a labinthefield experiment with spouses in ghana to map these intrahousehold responsibilities and evaluate their causal role on spouses expenditures and intertemporal decisions by demonstrating causes of inefficiencies in resource allocation and low savings my findings may help to inform on how womens role can be strengthened and on the potential for harnessing mens role in improving the household welfare
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accessible mri
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the amri accessible mri project by chipiron aims to develop and commercialize a breakthrough compact and affordable mri scanner operating at an ultralow magnetic field of around 10mt this radical innovation eliminates the need for costly massive superconducting magnets used in standard clinical mris chipirons proprietary squidbased detection system provides ultrahigh sensitivity to enable diagnosticquality imaging at 1001000x lower field strengththe goal is to make mri a vital noninvasive diagnostic tool accessible to a much wider population especially in developing regions and rural areas where current mri costs and infrastructure are prohibitive the open design of the device also accommodates patients unable to use traditional mris due to contraindicationsled by experienced technical experts chipiron has assembled proprietary ip and demonstrated core capabilities reaching trl 5 thus far the company has raised 43m from investors and grants chipiron is requesting a 25m eic transition grant which will be followed by a request for 15m eic accelerator investment to complete development through regulatory approvals and market launch over 20242027this longterm eic support will help derisk technical milestones and provide necessary scaleup capital it represents an ideal publicprivate funding mix tailored to the needs of deep tech medtech innovation the grant and investment will catalyze chipirons progress at a crucial juncture enabling this breakthrough deployable mri technology to benefit healthcare systems and patients worldwide
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campus iberus international doctoral programme of interconnected universities
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iberusinterdoc is an international doctoral programme of 4 interconnected universities of campus iberus aimed at recruiting 23 doctoral candidates dcs of excellence to develop interdisciplinary phd projects for 48 months in campus iberus territories campus iberus is the consortium of international excellence of the ebro valley bringing together four public universities from neighbouring regions in northeast spain universidad de zaragoza universidad pblica de navarra universitat de lleida and universidad de la rioja campus iberus strategy is set on the principles of aggregation internationalisation and specialisation on five strategic areas in line with the priorities of the smart specialization strategies ris3 of the four regions involved aragon navarre la rioja and lleida in catalonia 1 agrifood nutrition 2 health technologies 3 energy sustainability 4 social territorial development 5 circular bioeconomy dcs will be recruited in 2 calls open for 2 months to apply for a variety of research topics across those 5 areas appointments will be no later than m12 1st call and m19 2nd call to offer 48 months contracts the last 6 months of the contracts will be fully financed by own funds of campus iberus universities to cover 4 years even if exceeding the programme m606 the programme will offer dcs excellent supervision and professional development counting with preidentified potential supervisors proving experience and work in multidisciplinary projects and large networks of collaborators a total of 116 academic 48 and nonacademic partners 52 have associated to this programme to provide secondments trainings and career enhancing opportunities besides the networking events and special training programme organised by campus iberus this programme will make an imprint on the internationalisation and excellence that is long lasting at the institutional regional national and international levels
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lily a breakthrough technology to prevent chemotherapyinduced hair loss
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chemotherapyinduced alopecia cia is hair loss associated with chemotherapy treatment for cancer lily is a portable comfortable and effective cia prevention device that uses localised microvasculature compression therapy lmct to prevent cia the lily device uses this unique lmct technique to reduce perfusion at the scalp and prevent the destructive action of chemotherapy on hair follicles by applying a consistent lowlevel pressure between 35 and 60 mmhg to the local micro blood vessels which could deliver chemotherapy drugs to fastdividing hair follicles the vessels are temporarily compressed inhibiting drug deliverythe device comprises a proprietary pneumatic bladder network design and soft robotics system with the ability to noninvasively induce vasoconstriction in superficial vessels of the scalp to mechanically control tissue perfusion and an electronic control system for both patient management of the system and realtime feedback into the treatment protocol
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supporting innovation in healthcare public procurementinnohsupport
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innohsupports main goal is to bridge those gaps that hamper the progress in the definition implementation and adoption of innovative solutions in the healthcare ecosystem by offering a portfolio of advisory services for procurers stateowned enterprises smes and startups research and technological organisations innovation agencies and other organizations like investors responsible for promoting innovation procurementthese advisory services will include among others provision of training materials executive training interventions methodologies for innovation procurement dedicated coaching sessions innovation showcases scanning of relevant bidding opportunities matching with potential bidding partners acceleration services etcproject methodology is based on three pillars pillar i capacity building focused on building capacities and skills to the innovation procurement ecosytem pillar ii inventory of innovation procurement advisory services oriented towards the design and testing of a comprehensive set of advisory services covring the whole innovation process cycle pillar iii collaboration and matchmaking to foster the innovation ecosystem building by developing spaces for codesing and matchmakinginnohsupport is made by and for innovation actors the consortium brings together 7 partners 2 affiliated entities from 6 eu countries es nl ie bu beuk including a consultancy firm a university a public buyer and several associations with highly expertise within the public procurement of innovation in healthcare systems our target groups involve the whole innovation ecosystem actors public and private procurers stateowned enterprises smes and start ups research and technological organisations innovation agencies and other public bodies responsible for promoting procurement of innovation
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deciphering rhinovirusmediated macrophages impairment through the establishment of human induced pluripotent stem cellsderived macrophages
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a growing body of evidence suggest that viruses can modulate myeloid cells responses leading to long term impairment of monocytesmacrophages phenotypes whereas for virus directly infecting macrophages the longterm effects on these cells function and phenotype have been extensively studied for virus infecting other cell types the effects on macrophages have been overlooked yet recent data suggest that virusmediated modulation of macrophages can even occurred when the virus do not replicate in these cells indeed viruses have broader ways to modulate the innate immune responses than the one identified in permissive cells understanding the mechanisms of action employed by viruses to modulate macrophages responses could not only provide possible targets to eliminate the infection but also offer therapeutic options to preventavoid virusassociated pathogenesishuman rhinovirus hrv impairs macrophages responses upon secondary challenge with bacteria the host laboratory identified arpin as a critical factor targeted by hrv to alter the phagocytic activity of macrophages and showed that hrv16treated macrophages present a paralysed phenotype in terms of cytokine secretion the precise mechanisms governing the reprogramming of the macrophages are however not fully elucidated furthermore it is still unclear whether hrv needs to replicate within macrophages to reprogram their phenotype and functions therefore my objectives are to decipher i if hrv can replicate in alveolar macrophages and ii what are the hrvmediated mechanisms leading to impaired macrophages functionsmoreover the models employed to study macrophages present advantages but do not recapitulate organ physiology which plays a key role on the resident macrophage phenotype therefore i will develop a model of human lung alveolar macrophagelike cell laml derived from induced pluripotent stem cells hipsc to answer the abovementioned objectives
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sales marketing campaign
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emm is developing smart payload solutions with the focus on satellite electronics and onboard processing our first products smart processing module spm and smart power supply sps completed its first product cycles and first hardware designs are available the products complete into a smart onboard computer for newspace satellites operating higher performant payloads than typical cubesats nowadays can afford our smart processing module spm is an fpgabased systemonmodule providing data in the range of gbitsec throughput with realtime processing with the combination of fpga and processors our spm combines parallel and serial data processing while keeping the overall power consumption very low with builtin error correction coding and redundancy a reliable system is achieved implementation of artifical intelligence on the processors customized for applications yields cuttingedge technologyin order to gain more visibility on the market the next phase of the product development requires a strong sales marketing strategy and campaign these will include activities such as publications conference attendance building demonstrators social media appearance and update of business plan the marketing campaign will be proposed as a project for 2023
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deep bayesian reinforcement learning unifying perception planning and control
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for robots to assist humanity in homes or hospitals the capability to manipulate diverse objects is imperative so far however robotic manipulation technology has struggled in managing the uncertainty and unstructuredness that characterize human environmentsmachine learning is a natural approach the robot can adapt to a given scenario even if it was not programmed to handle it beforehand indeed deep reinforcement learning deep rl which has recently led to ai breakthroughs in computer games has been publicized as the learningbased approach to robotics to date however deep rl studies focused on known and observable systems where uncertainty was resolved by lengthy trial and error quickly learning to act in novel environments as required for robotics is not yet within our reachthe crux of the matter is the tight coupling between perception and control under high uncertainty the robot must actively reduce uncertainty while also trying to solve the task for complex and highdimensional systems we do not have a suitable algorithmic framework for thisin this proposal our overarching goal is to develop the algorithmic framework of using deep learning in problems that tightly couple perception planning and control for advancing robotic ai to reliably manipulate general objects in unstructured environmentstowards this end we shall develop neural network representations of uncertainty and algorithms that estimate uncertainty from data we will develop theory and algorithms for decision making under uncertainty bringing in a fresh perspective to the problem based on bayesian reinforcement learning bayesrl these advances will allow us to study safety certificates for deep rl and develop a general and practical methodology for learningbased robotic manipulation under uncertainty validated on real robot experiments aside from robotic manipulation we expect impact on various fields where decision making plays an important role
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prehistoric fisheries assisting marine baselines
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ensuring sustainable fisheries is one of the key issues to address the conservation of marine biodiversity and socioeconomic development such approaches usually operate based on fisheries records from the last decades which are proved to be inappropriate reference criteria for evaluating longterm impacts of fish exploitation whereas archaeological data is increasingly admitted as an essential source of information one of the most severely threatened marine regions is the indopacific which also holds a rich history of marine resources exploitation since at least the neolithic specific taxonomical identification of indopacific fish remains is still a pending task mainly due to the high diversity of fishes exploited and to difficulties in species identification from morphological analysis this situation impedes acquiring a deep understanding of the prehistoric fisheries and their impacts over time through the analyses of archaeological and modern fishes from the indopacific pristine will implement a back to the future approach to provide reliable ecological baselines and enhance our current understanding of fish exploitation from a longterm perspective by identifying and quantifying the range of fish species exploited dating back 5000 years to this aim pristine will apply cuttingedge proteomic methodologies to 1 develop a fingerprint collagen reference database of representative modern indopacific fishes 2 obtain the taxonomical identification of neolithic fish remains and 3 achieve a longterm evaluation of indopacific fisheries this research will contribute to attempts on the identification of healthy tropical reef fisheries and evaluation of anthropogenic impacts over time to assist in ensuring efforts to conserve the present and manage the future of marine scenarios
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a new view of young galaxies with alma and jwst
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the majority of the universes star formation occurred shrouded in cosmic dust making it extremely challenginghistoricallyto obtain a clear view of young z2 galaxy assembly while the atacama large millimeter array alma has already enabled significant progress including pioneering work by the pi to directly image this dusty star formation in early galaxies their existing stellar populations remain obscured at the same time our understanding of the molecular gas fueling that star formation is still limited to unresolved detections andor biased tracers fortunately we are on the verge of a breakthrough with the newly launched james webb space telescope jwst and the imminent arrival of alma bands 12 to this end the pi has obtained a suite of competitive proprietary data on jwst alma and band 12 pilot facilities fully capitalizing on this opportunity now requires a team of capable researchers by leveraging this data and a novel resolved spectral energy distribution sed fitting technique the proposed program will 1 reveal the hidden stellar populations in the dustiest young z25 galaxies for the first time testing predictions from hierarchical galaxy formation 2 detect and map the crucial co10 and co21 emission lines in a statistical sample of these same young galaxies directly measuring their full cold gas reservoirs via stateoftheart bayesian modeling and calibrating other lesswellunderstood gas tracers and 3 push studies of dust and gas in galaxies to the earliest cosmic epochs z65 including detecting their molecular gas via co32one of the key science goals for alma band 1thus revealing how the most massive early galaxies grew so quickly given her demonstrated track record leading a group and the wealth of data secured the pi is optimally placed to take advantage of this unique confluence of revolutionary instruments to provide a completely new view into how young galaxies built up their stellar masses
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control and complexity in quantum statistical mechanics
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developing a comprehensive theory of thermodynamics at the quantum scale requires a fundamental change of perspective with regards to its classical counterpart on the one hand measuring a quantum system will induce a nonnegligible backaction and an energy cost that is at least comparable to the energy scale of the system on the other hand controlling microscopic degrees of freedom and harnessing quantum effects provides novel opportunities with no classical counterpart in light of these facts control over different quantum features and quantum measurements themselves become valuable resources that need to be integrated into any selfcontained theory of quantum thermodynamics in this project we aim to address this grand challenge first we will develop a formal theory that includes control over quantum systems with fixed complexity to incorporate these concepts into thermodynamic considerations at the quantum scale second we will unveil the fundamental thermodynamic limitations on information acquisition by constructing a thermodynamically selfcontained description of the quantum measurement process finally we will carefully study current quantum technologies and with the help of our own lab and experimental colleagues we will devise experimental proposals and perform proofofprinciple experiments based on existing quantum technologies to make sure that the theoretical considerations describe relevant features
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recycling of high quality crm resources from machining tools for reuse applications
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recycling of high quality crm resources from machining tools for reuse applications resqtool will offer a sustainable and energy efficient solution for recycling and responsible supply of critical raw materials co w ta ti nb from eol products in hard metal industries of metalwood cutting construction and tool manufacturing by lowering the carbon footprint and energy consumption of zinc reclaim process and developing advanced hydro and solvometallurgical biochemical recycling based on agroindustrial wasteresqtool will explore the potentials of zinc reclaim and biochemical recycling processes in the complete value chain of hard metals to offer a responsible circular and sustainable supply of critical raw materials in europe together with a contribution to eu climate neutrality objectivesthe project will demonstrate within 4 years the capability of these two complementary processes to reuse and recover critical raw materials in all stages of the hard metals value chain ranging from collection logistics sorting and separation to cleaning refining and purification of materials demonstrating an approach towards zero waste manufacturing by means of energy and resource efficiency and by a validation using real parts from the hm industry the project will go beyond the stateoftheart in terms of maturity from trl 5 to 8 and hence contribute to the european green deal
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vesicular mechanisms of carbon fixation in calcifying cells of marine animals
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the process of biomineralization has profound impacts on the geology of our planet and is an integral part of the global carbon cycle by generating large amounts of caco3 bound in coral reefs chalk mountains and deep sea sediments mounting evidence demonstrate that many marine calcifiers generate biominerals by the intracellular formation of caco3 from seawater ca2 and metabolic co2 to date the underlying mechanisms that control the carbonate chemistry in calcifying vesicles are unknown which however will provide groundbreaking insights into a biological process that is capable of transforming a metabolic waste product co2 into a versatile construction material in the past 5 years my group has developed a unique methodological expertise to study the cellular physiology of calcifying systems building on this expertise carbocell will tackle the important but challenging task to identify and understand the mechanisms of vesicular calcification the sea urchin larva will serve as a powerful model organism that represents a prime example for the intracellular formation of caco3 and which allows us to employ specifically targeted molecular perturbations in combination with subcellular ion and ph recordings carbocell will take a stepwise strategy to systematically examine the mechanisms of vesicular calcification on the three main core subjects carbonate chemistry wp1 ionco2 transport mechanisms wp2 and vesicular volume regulation and trafficking wp3carbocell will provide a deep mechanistic understanding of the calcification process with strong implications for explaining and predicting responses of marine calcifiers to the global phenomenon of ocean acidification more importantly knowledge about the mechanisms that allow organisms to transform co2 into a construction material will pave the ground for novel biologyinspired solutions of co2 capture and utilization a basic science approach at the core of twentyfirst century concerns
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ai powered data curation publishing virtual assistant
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integrated highquality personal health data phd represents a potential wealth of knowledge for healthcare systems but there is no reliable conduit for this data to become interoperable aiready and reuseready at scale across institutions at national and eu level aidava will fill this gap by prototyping and testing an aipowered virtual assistant maximizing automation of data curation publishing of unstructured and structured heterogeneous data the assistant includes a backend with a library of aibased data curation tools and a frontend based on humanai interaction modules that will help users when automation is not possible while adapting to users preferences the interdisciplinary team of the consortium will develop and test two versions of this virtual assistant with hospitals and emerging personal data intermediaries around breast cancer patient registries and longitudinal health records for cardiovascular patients in three languages the team will work around four technology pillars 1 automation of quality enhancement and fairification of collected health data in compliance with eu data privacy 2 knowledge graphs with ontologybased standards as universal representation to increase interoperability and portability 3 deep learning for information extraction from narrative content and 4 aigenerated explanations during the process to increase users confidence by increasing automation of data quality enhancement aidava will decrease the workload of clinical data stewards by providing highquality data aidava will improve the effectiveness of clinical care and support clinical research in the longterm aidava has the potential to democratise participation in data curation publishing by citizenspatients leading to overall savings in health care costs through disease prevention early diagnosis personalized medicine and supporting delivery of the european health data space
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drug solution for bone fracture nonunions
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bone fracture nonunion fnu is one of the leading unmet orthopaedic clinical needs resulting in billions of healthcare costs annually without any drug approved by regulatory agencies for this debilitating indication due to considerable shortcomings of the current best practices in treating bone fnus patients are facing increased risks and morbidity the market has available only bone substitutes and enhancers with limited clinical efficiency highlighting an essential need for more effective therapies genera research is on its way to filling the gap with its globally patented osteogrowc product a novel biological drug transforming patients blood into bone the proposed osteoforunion project aims to develop and commercialize osteogrowc an innovative drug for bone regeneration osteogrowc is a novel treatment option for bone fnus an implant composed of an active substance recombinant human bone morphogenetic protein 6 rhbmp6 incorporated in an autologous blood coagulum abc where tricalcium phosphate tcp ceramics is added as a compression resistant matrix crm this combination forms a personalized implant that catalyzes bone growth at the implantation site it is easily prepared in the operating room from the patients blood without the need for a painful bone harvesting procedure as in current treatment practices with associated complications and morbidities donor site pain infection nerve injuries blood loss or iliac wing fracture etc and related additional healthcare costs osteogrowc targets the global fnu market which serves 6m patients yearly key overlapping markets are fracture fixation orthobiologics bone grafts and bmp osteogrowcs unique stance promises to revolutionize the fnu market the initial market entry will concentrate on the markets in the eu with 180000 diagnosed long bone fnus in europe annually simultaneously osteogrowc will be launched in the us addressing more than 120000 bone fnus
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experimental search for quantum advantages in thermodynamics
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the technology advances of the last decades are forcing us to rethink laws and concepts of thermodynamics an intense theoretical effort is underway to understand the role of quantum mechanical ingredients in thermodynamic processes this effort might ultimately lead to more powerful engines less energy waste fastercharging batteries however despite pioneering experimental work progress is hindered by the lack of a comprehensive experimental testbed for quantum thermal machinesin this project i aim to provide the most ambitious and systematic experimental search for quantum advantages in thermodynamics thus far based on a circuit quantum electrodynamics architecturei will first complement the toolkit of circuit quantum electrodynamics with a novel arrangement which i term the engineered physical bath this bath has a broadband ohmic spectral density it can be populated with any spectral distribution and coupled to quantum thermal machines with arbitrary strengths finally heat flows between the bath and the machine can be detected deep in the quantum regime and in a spectrally resolved way based on this augmented architecture i will implement three types of novel quantum refrigerators i devised each refrigerator to pinpoint the utilization of a specific quantum resource quantum coherence measurement backaction and collective effects i will measure the cooling power of the refrigerators while in situ exploring an unprecedently large space of parameters and connect my results to the most recent theoretical frameworksfrom this investigation i expect two kinds of scientific breakthroughs i observation of features that are unambiguously nonclassical in thermodynamic observables and ii determination of advantages enjoyed by quantum thermal machines when fairly compared to their classical counterparts broadly this project will deepen our understanding of quantum thermodynamics while establishing a new standard for experiments in the field
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reorienting the foundations of new science john philoponus and the modern theories of space and void 15201604
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jophil will provide the first systematic study into the origins of our modern conceptions of space and void as people living in the 21st century we give for granted that objects are tridimensional and that void space exists in nature or it can be produced artificially yet this was not always the case aristotle the great ancient thinker whose worldview remained dominant in europe well into the 17th century thought otherwise he understood objects as having two dimensions only and he resolutely rejected the idea that void space could possibly exist the first thinker to take exception to aristotles views was john philoponus a 6thcentury egyptian scholar writing in greek unknown in the middle ages philoponus works were rediscovered and translated only in 15thcentury italy once available they had a seismic impact on renaissance natural philosophy and science they provided renaissance scholars with the tools to rethink crucial aspects of the physics of the time and they laid the foundations of the new science which would emerge in the 17th century challenging the dominant eurocentric narratives about the origins of the scientific revolution jophil will map for the first time the rediscovery and progressive assimilation of philoponus innovative ideas of space and void into 16thcentury europe it will do so by examining the material recovery of philoponus texts in renaissance italy and by exploring their impact on five european thinkers who between 1520 and 1604 read and discussed philoponus works jophil contributes to reorient the origins of modern science in two different ways first it reevaluates the role played by noneuropean thinkers in the shaping of european science thus fostering a new idea of europe as the historical product of a variety of different cultures and traditions second it broadens the canon of the protagonists of modern science thus contributing to more inclusive research and educational practices in the future
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friends with benefits the role of endophytic bacteria in legume nodules containing nitrogenfixing rhizobia
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from shoot to root plants are exposed to a diverse range of microorganisms which can play a major role in plant health growth and development a small fraction of bacteria can cause disease the vast majority of bacteria has no known effect on the host but there are bacteria that are beneficial to the plant these microbes are able to protect plants from pathogens modulate immune responses or assist in nutrient uptake the best studied beneficial relationship for both plant and bacteria is the longterm biological interaction symbiosis between legumes and nitrogenfixing bacteria these bacteria called rhizobia are hosted in root nodules of legumes such as clover or alfalfa where they fix atmospheric nitrogen however rhizobia are not the sole occupants of nodules and despite early findings of the presence of other nodule associated bacteria nab the diversity and role of nab in symbiosis and plant growth has remained neglected legumes are important crop in agriculture worldwide and as such the potential of plant growth promoting bacteria and increase of nitrogenfixation abilities is a major topic of research aiming to enhance agricultural productivity investigating the genetic material of all the microbes the socalled microbiome of legume root nodules will allow investigation of genetic features of those bacteria which contribute to increased plant growth and nutrient availability here i will use a holistic sequencing approach to i unravel the diversity and metabolic properties of nab in legume nodules and ii gain insights into the environmental factors affecting nab community composition iii determine to what extent the bacterial community in the soil rhizosphere drives nodule community composition the proposed research will provide a better understanding of the biological role of all cooccurring bacteria in nodules in the otherwise binary interaction of legumerhizobia symbiosis
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nanohelicoid metamaterials templated by cellulose nanocrystals with endtethered polymers
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chirality plays a fundamental role in natural sciences and pharmacology the ability to detect chiral molecules relies heavily on inherently weak circularly polarized lightmatter interactions such interactions are enhanced in the presence of chiral metamaterials which exhibit extraordinary electromagnetic properties not observed in nature to date large and broadband circular dichroism in the uvvisible spectrum requires arrays of metallic nanohelices in order to combine internal and bragg resonances however their fabrication relies on costly electronion beam lithography or physical vapor deposition in which it is difficult and timeconsuming to control nanoscale morphology over large areas new types of helix metamaterials and engineering processes based on selfassembly concepts are absolutely necessary in order to be viable for future technologies nevertheless selfassembled metamaterials with large broadband and tunable chiroptical responses in the uvvisible region is a great challenge due to the required subwavelength feature sizes to this end the helicoidal morphologies of chiral liquid crystals provide the ideal platform for maximizing chiral lightmatter interactions the objective of celicoids is to investigate the use of the chiral liquid crystal phases of cellulose nanocrystals with endtethered polyoxyethylene analogues as templates for the fabrication of a new class of metamaterial solid metallic nanohelicoids a recent breakthrough that now makes this project possible is the discovery that such cellulose nanocrystal hybrids form chiral liquid crystal phases as one of the very few researchers in the world with the combined expertise in cellulose chemistry polymer grafting and colloidal assembly i am the ideal candidate to achieve success new functionalities are envisioned thereafter applicable to future devices for invisibility cloaking superresolution imaging and chiral sensing prompting a change in paradigm in metamaterials
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developing scientific research with ethics and integrity
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different machines of trust in science have been identified in the literature research ethics research integrity science communication benefit sharing and technology assessment previous eu funded projects have focused on particular actors of the trust in science ecosystem eg scientists research funding organisations research ethics committees to explore the impact of particular machines eg science communication research ethics verity goes beyond the state of the art by conceptualising stewards of trust as the actors of the ecosystem that are responsible for upholding societal trust in science and facilitating sciencesociety cocreation either this refers to formally responsible organisations like research funding organisations and higher education institutions or it refers to de facto responsible organisations like social media companies and video streaming platforms which influence societal perceptions of science and innovation verity combines multidisciplinary expertise both from the social sciences and engineering to synthesise existing knowledge to evaluate tools and methods for enhancing trust in science through original research and smallscale participatory activities before producing the verity protocol of recommendations for stewards of trust verity brings forward interdisciplinary expertise to perform network analysis and execute interventions on social media to validate the verity protocol and alleviate practical barriers for its uptake in practice by different stakeholders verity findings will be widely disseminated to different stewards of trust such as policymakers research funding and performing organisations higher education institutions and other research and innovation actors to enhance societal trust in science and facilitate sciencesociety cocreation
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a bone marrow mimicry bioreactor for cost effective production of hematopoietic stem cells
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hematopoietic stemprogenitor cell hspc therapies have the potential to treat over 70 diseases including blood cancers and leukemia and are one of only 22 advanced therapy medicinal products currently approved by the european medicines agency however the number of hspcs derived from a single blood donation can be insufficient for modern therapies which typically require a minimum of 107 cells to service adequate treatment regimes hspcs must be expanded in the laboratory at great financial expense resulting in exorbitant treatment costs of up to 315000 new methods of ex vivo hspc expansion are therefore required to reduce production costs and ensure therapy affordabilitythe industry standard for hspc expansion utilises liquid suspension bioreactors where cells are diluted in litres of culture media to a final concentration of only 1035 cellsml this liquid media containing large amounts of expensive nutrients provides high cell expansion but results in high production costs liquid suspension bioreactors vary significantly from how humans grow hspcs within highcelldensity tissue 10811 cellsml which require only a fraction of the nutrient quantities percellthe bone marrow is the human bodys natural hspc bioreactor and provides a defined microenvironment for optimal cell production i aim to artificially replicate these niche conditions by creating a marrow mimicry bioreactor marrowmimi to maximise ex vivo hspc expansion by 1 formulating a hydrogel scaffold to mimic the bone marrow extracellular matrix 2 utilising stateoftheart 3d printing technologies to create a marrowlike perfusion bioreactor and 3 optimising reaction conditions to maximise hspc expansion and minimise nutrient demand the ability to minimise hspc expansionassociated costs could ensure lifesaving therapies are more widely available to the community therefore marrowmimi will focus on optimising methods for cost effective ex vivo hspc production
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impact of climate change on twilight zone fishes during earlystage development
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twilight zone tlz hosts the largest and least exploited fish stocks of the worlds oceans these fishes play a key role in ecosystem services such as sustaining other relevant marine species and global carbon cycle the tlz research is still in its infancy but the high biomass has raised interest in its exploitation mainly as fish meal but also as nutrapharmaceutical compounds moreover climate change is altering the environmental conditions in ways of which we do not know how life in tlz will be affected it is alarming that this vast ocean domain is at risk even before any of the potential consequences of fishing are fully understood one of the most threaten and less studied aspects of the tlz is the early life stage of its fishes please project aims to fill this gap of knowledge the first objective is to set background information about basic biology of the embryonic and larval development of different tlz fishes it will be achieved by establishing a suitable methodology for assisted reproductive technology in laboratory conditions since the wild tlz fishes are vulnerable to captivity the reproductive methodology will be transferred to the nonacademic partner for developing pioneered aquarium exhibitions the second objective is to examine the developmental responses of the embryos and larvae due to ocean warming and acidification under climate change scenarios it will be monitored via the developmental variability metabolism physiology morphometry and mortality rates of the specimens the outcomes of the project will be of paramount importance to forecast the impact of climate change on the community of tlz fishes and will open a new era for more investigation in this pristine and vulnerable zone of the planet finally a range of interactions with stakeholders and public will ensure the project exploitation and improve the decisionmaking capacity of the policymakers related with climate change and fishing activities in the tlz
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comprehensive strategies to tackle malignant tumors from nanomedicine and theranostics to precision medicine
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strikedn will raise excellence in research and training in nanomedicineprecision medicine creating new generation of entrepreneurial and innovative multidisciplinary doctoral candidates new experimental aspects on design and synthesis of nanostructured magnetic materials will be applied to the development of innovative magnetic fieldresponsive nanotherapeutics for osteosarcoma os combinational therapy moreover the peculiar features of strike nanomaterials will be exploited for liquid biopsy using biological samples of brca breast cancer bc patients the cooperation among outstanding universities research institutes and industries will provide the dcs with transnational exchanges and the most innovative research trainings in novel anticancer therapeutic strategies including in vivo biological evaluation imaging in os and early diagnosis in bc strike will provide enhanced career perspectives in academic and nonacademic sectors for 8 dcs in highly innovative fields by interdisciplinary mobility among 12 institutescompanies in 8 eu countries strike aims to 1 develop 8 highly skilled employable doctoral candidates 2 enhance interdisciplinary capacity and cooperation within the eu nanomedicine and precision medicine research networks 3 strengthen eus competitiveness and growth in nanomedicine and precision medicine through the translation of the consortium researchinnovation outputs the consortium will fulfill its goals through a achieving research excellence b providing a complete cutting edge research and innovation training program with some of the european top research institutes and industry partners c hosting interdisciplinary and commercial workshops seminars and outreach events d maximizing knowledge transfer using open science and patents e delivering highly trained professionals whose profiles fit within the requirements of academia industry and publicprivate institutions fostering their employability and promoting the innovation of eu research
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innovative treatment for extrapulmonary benefits in copd effects and mechanisms of supramaximal highintensity training
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given the substantial negative impact of extrapulmonary manifestations on vital clinical outcomes including mortality the need for new effective treatment modalities also beyond the lungs has been highlighted as an urgent challenge in the management of chronic obstructive pulmonary disease copd one of the most common and deadliest diseases of the 21st century the aim of copdhit is to pave the way for new understanding of the development and treatment of extrapulmonary manifestations in copd with a focus on brain health muscle quality and cardiac function to do this i will focus on the following research objectives ro ro1 determine the effect of supramaximal highintensity training hit on the brain muscle and heart ro2 determine how exercise training and inflammation impacts the trajectories of neurodegeneration ro3 develop a novel invitro model to determine signaling pathways following various loading intensitiesto reach these objectives i aim to conduct highquality multicenter randomized controlled and experimental trials further i will lead an international research alliance with access to stateoftheart research infrastructures and enable a unique interdisciplinary approach to fulfill my goals this includes using advanced measurement techniques for muscle brain and cardiorespiratory evaluations muscle biopsy analyses invivo invitro strategies and combining quantitative and qualitative methods taken together with copdhit i am in a strong position to perform an international novel project that will determine how to enable extrapulmonary benefits in copd in a hitherto unprecedented way
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hybrid human artificial collective intelligence in openended decision making
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hacid develops a novel hybrid collective intelligence for decision support to professionals facing complex openended problems promoting engagement fairness and trust a decision support system haciddss is proposed that is based on structured domain knowledge semiautomatically assembled in a domain knowledge graph dkg from available data sources such as scientific and gray literature given a specific case within the addressed domain a pool of experts is consulted to i extract supporting evidence and enrich it generating a case knowledge graph ckg as a subset of the dkg and ii provide one or more solutions to the problem exploiting the ckg the haciddss gathers the expert advice in a collective solution that aggregates the individual opinions and expands them with machinegenerated suggestions in this way hacid harnesses the wisdom of the crowd in openended problems relying on a traceable process based on supporting evidence for better explainability a set of evaluation methods is proposed to deal with domains where ground truth is not available demonstrating the suitability of the proposed approach in a wide range of application domains demonstrations are provided in two compelling case studies contributing to the un sustainable development goals crowdsourcing medical diagnostics and climate services for urban adaptation
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learning isoform fingerprints to discover the molecular diversity of life
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did you know that 80 of all proteomic data is not utilized proteins play a vital role in all biological processes and organisms we believe that different versions of a single gene product protein isoforms shape the molecular diversity of life however comprehensive evidence on proteinlevel is not available chromatographycoupled tandem mass spectrometry lcmsms is the defacto standard for measuring proteomes but it is not good at identifying isoforms because at least 80 of the recorded information is never used i argue that isoforms leave a deterministic multidimensional fingerprint origins representing their physicochemical properties in each proteomic measurement therefore the central aim of this project is to discover and quantify protein isoforms systematically by a novel msbased proteomics data analysis strategy by tapping into the wealth of data the proteomics community has already amassed i will train deep neural networks that allow the prediction of origins second i will implement an innovative data analysis strategy that utilizes origins to identify and quantify isoforms third i will demonstrate that origins can be used to substantially broaden our understanding of the molecular diversity of life by showcasing its application on four emerging and challenging questions in proteome research of varying biological and technical complexity this will allow me to address a fundamental open question in biology to which extent and prevalence isoforms are actually translated and what functional roles they might be associated with origins will improve the sensitivity biological resolution and accuracy at which proteins and their isoforms can be identified and quantified beyond this the concept of origins can be applied to and improve any proteomics experiments and thus holds the potential to revolutionize msbased proteomics as a technology and elevate the whole field of proteinbased research
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strategic alliance for building european fusion energy partnership
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the go4fusion project will lay the groundwork for a strong collaborative european fusion energy community preparing for the future establishment of a publicprivate partnership ppp this ppp will facilitate funding for industrial and rd activities key objectives include consolidating the european fusion stakeholder network efsn creating an industryled association representing european fusion industries and research organizations and developing a strategic research and innovation agenda sria to shape short medium and longterm rd in fusion additionally go4fusion will explore the creation of a trade association to support the growth of the european fusion industry through advocacy networking and education the project will also address intellectual property management and technology transfer ensuring european innovations in the fusion sector are protected and effectively exploited the future ppp must ensure the successful takeoff of fusion technology and support the accelerated advancement of research and innovation in this sector this project will help enhance the visibility of fusion technology in europe targeting policymakers citizens industry and researchers the consortium will include major actors from the current fusion community led by enea the italian agency for new technologies energy and sustainable economic development innovation major research institutes from france germany italy and spain will complement the consortium alongside key industrial players this consortium is wellsuited to building the fusion community in europe and possesses the necessary knowledge and network to engage the entire fusion value chain driving the establishment of the future partnership and fostering europes strategic autonomy and competitiveness for the future commercial deployment of fusion energy
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advanced systems and solutions for better practices against hazards in the aviation system
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albatros overarching ambition is to maintain a high level of safety in aviation in view of extreme weather conditions expected changes brought about by the evolution of aviation systems especially new fuel and energy systems including hydrogen which will be integrated in the coming years to both future aircraft and airport infrastructures albatros activities target the increased resilience against safety issues both on the ground and in flight to ensure the survival of passengers and crew as well as their evacuation and rescue in case of emergencies albatros objectives are to develop a concept for realtime sharing of safety intelligence to support decision making on safety issues emergencies and crises develop safety risk models and analyse safety data for prediction and prevention of emerging and future hazards in aviation linked to data4safety develop survivability measures to mitigate safety issues and risks assess and improve human performance and develop best practices for decision making in the handling of crises and emergency situations validate and demonstrate concepts technologies and decision support tools exercises at airports simulations and laboratory tests conducted in close collaboration with eaccc gadss and acieurope disseminate communicate and exploit project key results and outcomes including through emergency response training exercisesalbatros will work on maturing technologies and solutions up to trl6 which will be compatible with eaccc and gadss requirements initially scenarios requirements concepts of use and relevant technologies will be agreed upon before development activities are performed on safety modelling and data analysis survivability as well as decision support tools and best practices the results of these developments will then be integrated and validated through 15 demonstrations in relevant environments across europe airports flight simulators or crisis centres
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environmental exploitation of political economics
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we need a theory to explain why society has so far failed to address climate change and other environmental problems after all it has been able to deal with other challenges ranging from wars to trade barriers and most recently covid19 in this project we seek to shed light on two important questionsi what political economics forces explain the failure to deal with environmental problems ii how can environmental agreements and contracts exploit domestic political forcesthe first positive part seeks to develop dynamic political economics models that can be combined with models of climate change and other environmental problems the goal is to learn more about what political economics forces or constraints are best able to explain the observed inefficiencies in environmental policies this knowledge is necessary before we can analyse which policies are best subject to the relevant constraintsthe second normative part is more groundbreaking because it investigates how international environmental policies can exploit the political forces that are important at the domestic levelintuitively when desirable policies are hindered by political forces such as present bias and time inconsistency an incumbent may value a treaty that offers precommitments or credibility this value implies that the incumbent can be persuaded to contribute more to emission cuts for example if the agreement is designed so that it helps the incumbent overcome domestic political constraints by drawing on contract theory and organizational economics we will investigate how international policies can exploit timeinconsistent incumbents demands for commitment how statusquo biases offer credibility and how inattention permits persuasionthe project will contribute methodologically to political economics and contract theory the lessons for policymakers may be invaluable
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communityled creation of living spaces in shifting landscapes for climateresilient land use management and supporting the new european bauhaus
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landshift is a groundbreaking initiative aimed at addressing the urgent challenges of climate change biodiversity loss and unsustainable land management practices with a focus on the eus landuse sector landshift seeks to develop innovative solutions that not only mitigate biogenic emissions but also enhance ecosystem resilience and promote sustainable resource management landshift aims to support the eus ambitious climate goals by maximizing net removals from lulucf while minimizing biogenic emissions from agriculture by strategically utilizing living earths integrating fao lccs with optimized eo data and data cubes as centralized data hubs the project aims to implement tailored strategies for local and regional contexts fostering stakeholder engagement and collaboration central to landshifts approach is the integration of nbs aligned with the principles of the new european bauhaus these solutions leverage natural processes and ecosystems to enhance carbon sequestration improve biodiversity and strengthen ecosystem services by harnessing the power of nbs landshift aims to create synergies between climate mitigation biodiversity conservation and sustainable land management furthermore landshift recognizes the importance of datadriven decisionmaking and monitoring to track progress and inform policy development the project will establish robust mrv systems to ensure the effectiveness of implemented strategies and measure their impact on biogenic emissions biodiversity and ecosystem health in addition to technical solutions landshift places a strong emphasis on policy influence and capacity building through targeted outreach and engagement activities the project aims to raise awareness build capacity and foster collaboration among stakeholders at all levels by empowering policymakers land managers and local communities landshift seeks to create an enabling environment for sustainable land use sector and management practices
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just times temporalities and uncertainties for marginalised groups in cities
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this project will advance knowledge on how cities contribute to the production of time of marginalized groups cities are key nodes in the production of social inequalities of time as places where national and global processes locate and where many precarious groups reside and their uncertainties are strongly reflected this project analyses time of filipino domestic workers in hong kong and critically examines the role of the city in the production of time for this marginalized group the study will reveal the spatiotemporal causes of urban marginalized migrants and its broader implications for research on time in urban sociology the objectives are o1 to analyse the temporalities at play in the lives of the migrant domestic workers in hong kong o2 to analyse the lived experiences of time in the migration trajectories of filipino domestic workers in hong kong and retired migrant domestic workers in metro manila and o3 to draw implications and develop a conceptual framework for the study of time of marginalized groups in urban sociology and publish this in highimpact journals these objectives will be achieved using qualitative research among policymakers ngos and other agencies as well as filipino domestic workers in hong kong and retired domestic workers in metro manilathe project establishes a valuable exchange of knowledge and skills between the researcher and the institute for housing and urban research ibf at uppsala university the supervisor prof miguel a martnez is a leading scholar in urban sociology and has worked on topics including migrant workers citizenship and the production of urban space while the researcher brings considerable complementary knowledge of the social theory of time in cities and everyday life ibf provides an excellent multidisciplinary research environment where the researcher will be able to gain skills and experience relevant to her career goal to obtain a position at a firstrate university in the eu
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behavioural replication of human drivers for ccam
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europe must seize the opportunities presented by connected cooperative and automated mobility ccam for its deployment powerful tools enabling the design and analysis of ccam components digitally and with a common language between tiers an oems are neededthe lack of a validated and scientifically based driver behavioural model dbm to cover the aspects of human driving performance is one of the main shortcomings of ccam development it allows to understand and test the interaction of ccam with other cars in a safer and predictable way from a human perspective dbm is the cornerstone for the development of ccam components it will guarantee its digital validation and if incorporated in the ecus software will generate a more humanlike response of autonomous vehicles at any level and increase its acceptance the main objective of bertha is to develop a scalable and probabilistic dbm based mostly on bayesian belief network bbn the dbm will be implemented on an opensource hub repository to validate technological and practical feasibility of the solution with industry and become a unique approach for the model worldwide scalability the resulting dbm will be translated into a simulating platform carla using diverse demos which allows building new driving models in the platformbertha will also include a methodology which due to the hub will share the model to the scientific community to ease its growththe project includes a set of interrelated demonstrators to show this dbm approach as a reference to design humanlike easily predictable and acceptable behaviour of automated driving functions in mixed traffic scenariosbertha is expected to go from a trl 2 a trl 4 the requested eu contribution is 7981801 the consortium 14 entities from 6 countries including south korea deem this project as vitally relevant to the ccam industry due to its impact for safer and more humanlike cavs and its market and societal adoption
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formation clustering and atmospheric impact of clusterable organic compounds
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atmospheric aerosol particles have a critical impact on earths radiative balance and human health oxygenated organic molecules play an important role in the formation and growth of aerosol particles to contribute to initial steps of particle formation a compound must either condense from the gas to the particle phase or undergo clusterphase protontransfer or other chemical reaction i define a clusterable organic compound coc to be an oxygenated organic molecule which can participate stable cluster formation under atmospheric conditions due to the limited knowledge of the formation structures and properties of cocs the exact mechanisms for the formation of aerosol particles remain puzzling my vision to bridge this longlasting knowledge gap is to implement a unique computational approach to tackle bottlenecks in studies of complex reaction mechanisms to combine a versatile suite of quantum chemical methods to accurately investigate cluster formation and properties and to combine the best qualities of mass spectrometry and matrix isolated vibrational spectroscopy to solve structures directly from the reaction chamber the scientific objectives are to 1 solve the role of dimerizationinitiated autoxidation mechanism in coc formation 2 develop an instrumentation capable to reveal molecular structures and properties of cocs 3 determine the formation mechanisms and rates of coc containing particles and 4 estimate the atmospheric impact of newly formed coc containing particles this project will establish the molecularlevel foundation for future atmospheric research by solving how cocs form what is their contribution to particle formation and properties and what is their impact for our climate this research results highly accurate reaction kinetics and cluster thermodynamics parameters for atmospheric models which are crucial to constrain the large uncertainty in climate predictions caused by small aerosol particles
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poor prognosis colorectal cancers display selfsustained growth by nichemimicry
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colorectal cancer crc is a heterogeneous disease with widely variable clinical outcomes i previously contributed to a unifying molecular classification of crc the consensus molecular subtypes cmss the mesenchymal subtype cms4 representing 25 of all crc patients is characterised by early metastatic dissemination and poor response to therapy this is often attributed to activated and rich stroma and therefore much attention in the field goes to dissecting the interaction of the mesenchyme with the cancer cells in these tumours however in this research program i will investigate a radically different hypothesis mesenchymal crcs display selfsustained growth by nichemimicry nimicry i define nimicry as the adoption of niche features by cancer cells thereby rendering the cancers independent of microenvironmental signals for their expansion this hypothesis is directly based on preliminary experiments from my laboratory which demonstrated that mesenchymal crcs are not dependent on external growth factors for expansion in vitro and display autocrine and paracrine loops that drive selfsustained growth the abundant stroma in mesenchymal crcs is secondary to the growth factors and cytokines produced by the tumour cellsto study this concept i will employ primary human crc models in combination with molecular and functional characterisation to delineate the selfsupporting signalling loops in a patient specific fashion these studies are paralleled by the investigation of clonal dynamics within established human crcs by means of a novel genetic lineage tracing strategy in combination with quantitative analysis dedicated analyses will resolve the impact of nimicry on metastasis formation therapy resistance and tumour evolutionthese studies into nimicry as a critical concept in tumour biology will importantly advance our understanding of the signals that drive crc growth and progression and will pave the way to new treatment strategies
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habitat tracking for the conservation of huntable bird species
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fortytwo huntable bird species are declining in numbers and we crucially miss information on their habitat needs in order to organize habitat management and restoration to secure restoration their status in habitrack we propose to deploy multiplesensor tracking tags on migratory species to tackle fine scale habitat needs of mature individuals for a variety of unsecured huntable migratory bird species in order to provide appropriate recommendations for ongoing habitat management policies and adaptive management initiatives the project will consider breeding habitats first studying links between population trends and habitat use across the european range and the projected impacts of ongoing climate change on demography then modelling the response curves of individual use of landscape elements within a home range to identify potential optimal values we will also consider integrated migratory connectivity to further link habitat needs on nonbreeding grounds wintering grounds and stopover site networks to population trends tackling potential carryover effects on breeding performance we will finally investigate the ways remote tracking data can bring new information on breeding status and performance and on cryptic mortality to allow the future remote monitoring of demographic parameters proofs of concept will be developed early in the project from species with already available large tracking data sets a first obvious candidate is the eurasian curlew developments in the project will make use of already available data then focus on filling knowledge gaps in relation to the amount and quality of habitat the efficiency of the pathways to impact will be achieved by the mobilization of various organizations and stakeholders in a steering committee ensuring the dissemination and appropriation of the scientific outcomes and management recommendations
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jumbo phages in translational enzyme research
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jumbo phages are large viruses of prokaryotes with 200 to 800 kilo basepair kb genomes well beyond the size of small phages that average around 50 kb while investigation of small phages over the last century has transformed fundamental and translational biosciences jumbo phages research is only in its infancy the majority of jumbo phage genes are uncharacterized and cannot be annotated by comparative genomics thus it is unknown how the genes function in jumbo phage biology importantly jumbo phages generally carry genes to take over their hosts transcriptional and translational machinery in addition to harboring factors that may modify and degrade nucleic acids many of the unannotated genes might have similar characteristics which could be exploited for translational enzyme research however those genes remain experimentally underexploredthe jupiter project tests the hypothesis that some of the uncharacterized genes have properties that affect their hosts transcriptional and translational machinery and that some of the gene products could modify or degrade nucleic acids using an innovative highthroughput in vitro characterization strategy i will experimentally annotate gene products of unknown function according to their ability to catalyze the abovementioned reactions known and novel jumbo phages will be isolated and characterized to expand our current knowledge of jumbo phage biology promising candidate factors will be characterized in vitro and in vivo to understand their function and to facilitate translational enzyme researchmy results will provide i an innovative method for experimental gene annotation unraveling new mechanisms in jumbo phage biology ii an expansion of the available jumbo phage diversity and iii detailed insights into the function of novel factors unlocking future translational applications in biotechnology
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a 100 sustainable and infinitely scalable electrical energy storage system
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aquabattery is a revolutionary battery storage technology that offers unlimited storage capacity inexpensive scaling and is 100 sustainable aquabattery is based on a simple principle input renewable energy store it in seawater then return electricity when there is energy demand the core innovation is the use of seawater as a sustainable safe and scalable energy storage medium this is enabled by the companys patented membrane stack technology that utilizes bipolar membrane electrodialysis and reverse electrodialysis for energy storage and discharge during the charging phase saltwater flows through the membrane stack and produces an acid and base stream that is stored in tanks during discharge the solutions flow back through the membrane stack to generate salt water and release energy with this disruptive solution aquabattery aims at revolutionizing the energy storage world fostering the growth of renewable energy technologies and stopping the use of toxic materials
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the trail of sulphur from molecular clouds to life
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sulphur is the tenth most abundant element in the universe and is known to play a significant role in biological systems moreover some sulphur compounds have been proposed as necessary catalysts to form amino acids in the interstellar medium however while the carbon and oxygen budgets have been extensively studied sulphur is the only element whose gasphase abundance is still uncertain by several orders of magnitude hindering the usage of elemental sulphur abundance as a reliable tool to probe planet formation this lack of information is due to the scarcity of observations specially in protoplanetary disks and the still large uncertainties in the sulphur chemical network this project takes a decisive step to fix our knowledge of the sulphur chemistry with an innovative methodology that rests on three pillars i to create an unprecedented database of high quality observations of sulphurbearing molecules which allows us to trace the sulphur content from the natal molecular clouds to protoplanetary disks observations of the awarded iram large program gems have already provided part of this database ii to perform ab initio calculations and laboratory experiments to estimate the key reaction rates that are needed to fix the sulphur network and make chemical models reliable now we know that the chemical composition of planetforming disks is to a large extent inherited from the earliest phases of star formation iii to perform bifluid gasdust 3d magnetohydrodynamics simulations with chemistry coupled chemomhd to follow the chemical evolution of the material from the natal cloud to the planetforming sites and hence to obtain accurate chemical predictions this can be extensively done by using artificial inteligence to reduce the computing time at the end this project will disentangle how sulphur was delivered to protoplanetary disks which is an essential step to understand planet formation and the emergence of life
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shared heritage early modern colonial forts in the south china sea scs bordering communities
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forts of the south china sea bordering countries built between the sixteenth and nineteenth centuries are a notable remain of the long and complex history of encounters and exchanges with european powers practically forgotten by scholars and local administrations it is time to enhance their value with a new discourse as a shared heritage between european and local communities this project aims to 1 show how the local practices in the south china sea bordering countries mingled with the european theory of fortifications 2 raise the value of the shared fort heritage to create joint forces to preserve it 3 digitalize forts to make them publicly available as captured memory of current state it is planned to begin with traditional methods of study among which are a historical analysis using archival documents and morphological analysis also the tls methods will be used for digitalization as it allows a continuous recording of objects with a high level of accuracy for further analysis and modeling then an entirely new interdisciplinary research methodology will be introduced namely the transcultural interpretation of shared heritage that involves hbim novel typomorphological analysis finite element analysis fea material analysis and statistics the main foreseen results are the change of societal views on colonial forts the new shared view on the valuable structures and their digitalization for universal public access during centuries to come
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agile exploration and geomodelling for european critical raw materials
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new environmental economic and societal requirements in the eus transition to a lowcarbon and digital economy call for innovative methods technologies and techniques to be developed and applied in mineral exploration to unlock the crm potential in europe agemera will conduct local stateofart geological and geophysical surveys over a total of 4700 km2 in order to detailly map crm resources in 6 eu countries and 1 third country zambia the geophysical field trial surveys will demonstrate three novel noninvasive survey methods at up to a trl5 based on remote sensing and related data analysis 1 passive seismic methods 2 multisensing drone system combining magnetic radiometric and electromagnetic sensing and 3 muonbased multidetector density detection system the project will use data from openaccess databases eg european geological data infrastructure egdi the data collected from the field by project geoscientists and various geophysical survey methods to refine and improve the genetic mineral system models of the various deposit types known to contain lithium cobalt molybdenum vanadium pgms niobium tantalum bauxite and ree the project will introduce the existing guidance for the application of unfc for mineral resources to the partner countries through stakeholders courses and public events the project will survey citizens in the project countries create a crm educational package targeting schools and universities publish an online crm serious game organise public events as well as online news flashes with the aim to reach 5000000 citizens by 2030 the project will create an openaccess softgis analysis and database on peoples social cultural environmental and economic concerns related to mining and mineral exploration these data enable the creation of socioeconomic potential maps to be used in parallel with the geological potential maps consequently ensuring a basis for socially accepted and sustainable mining
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a strategic roadmap towards the next level of intelligent sustainable and humancentred smes
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over the last ten years many efforts have been made to transfer industry 40 from research to practice recently great progress has been made to introduce also smes to the use of industry 40 the next big challenge for smes will be to implement the dual or twin transformation in sense of a digital transformation towards more intelligent manufacturing while tackling and accelerating the sustainability transformation to enhance economically socially and environmentally sustainable processes factories and value chains in this project we aim to take smes to this next level by developing a strategic roadmap for making them not only intelligent but also sustainable resilient and humancentric this next level of smes will be data and intelligencedriven thus using available data to acquire new knowledge and to apply it for optimization purposes using artificial intelligence in a secure way further a great attention is paid to how manufacturing and value chains in smes can become more circular green and resilient by considering ethical human and societal values for more sociocentred factories in this next level of sme 50 factories the human will play a much more important albeit changing role besides identifying emerging future work profiles and competencies of sme employees we will develop guidelines for rendering sme workplaces in industry more inclusive and diverse and for empowering them for increased wellbeing and attractiveness of sme jobs the main outcome of the project is to develop and propose a strategic guideline and roadmap that will facilitate smes in europe and worldwide to achieve the above mentioned goals to expand the impact and exploitation an sme 50 stakeholder training network will be build the applicability of the results and guidelines is ensured through a close collaboration with nonacademic partners smes in the partner network and the aim to validate the results through demonstrators and case study research
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implementing cationic paths in aliphatic ch oxidation
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finding new reaction paths and establishing new frontiers in ch bond oxidation represent breakthroughs in organic chemistry going beyond preliminary findings discovered by the fellow dr marco galeotti this project will focus on the unprecedented implementation of cationic paths in ch bond oxidation diverging from the ubiquitous radical paths the proposed objective represents a change of paradigm in ch functionalization from a mechanistic perspective and in a broad perspective in organic chemistry because it will deliver a novel methodology to access unique and intriguing cyclobutane structures by singlestep functionalization of aliphatic ch bonds these transformations will be carried with a view to sustainability through the employment of earth abundant 3d catalysts and an ecofriendly oxidant such as hydrogen peroxide this proposal will benefit from the accumulated wealth of experience of marco galeotti in organic chemistry and in the mechanistic aspects of the factors governing reactivity and selectivity on aliphatic ch bond functionalizations this in combination with the supervision of prof miquel costas an internationally recognized expert in the chemistry of biologically inspired oxidation catalysis applied to organic chemistry will offer the possibility to uncover valuable mechanistic insights of this new oxygenation pathway the proposed project will represent a milestone in synthetic organic chemistry because it will deliver a wide variety of stereo and enantioselective fourmembered carbocycles in the oxidation of cyclopropyl derivatives for a broad spectrum of aliphatic ch bonds this transformation will be also applied in latestage csp3h diversification of natural product and pharmaceutical by placing this proposal in the realm of societychanging outcomes
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secondmodelocking for a universal materialprocessing laser
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lasers are ubiquitously used to cut drill mark texture 3d print materials materialprocessing lasers remain divided into cw nanosecond and ultrafastpulsed each excelling and falling short differently cw lasers reach the highest powers cost the least and are far more common but cause heat damage and their utility is materialspecific ultrafast lasers achieve supreme precision on any material but remain niche as they are inefficient and expensive nanosecond lasers fall in between we propose to overcome this categorisation by inventing a universal laser that can process any material from metals to living tissue exceed the efficiency limit of equilibrium thermodynamics approach the quantum mechanical limit and surpass the speed of industrial cw lasers it will do so by taking our invention of ablationcooled lasermaterial removal nature 2016 to uncharted territory where electrons and atoms will be kept perpetually far from mutual equilibrium even between successive pulses the same laser will perform 3d printing or tissue welding by switching to quasicw operation to this end we need the unprecedented combination of 30fs pulses at 1kw average power and onthefly tunable repetition rates of 011 thz the latter implies an impossibly short laser cavity the alternative is to support multiple pulses in the same cavity but this has long suffered from poor performance due to fundamental reasons regular modelocking generates ultrashort pulses by locking cavity modes via nonlinear feedback but it has no mechanism to mutually lock multiple pulses we fill this conceptual gap by introducing a nonlinear time filter this innovation underlies the new laser concept of second modelocking which will create thousands of ultrafast pulses in perfect periodic arrangement to reach extreme repetition rates with a disruptive potential for not only material processing and laser surgery but also microwave thz generation beyond5g communications laser ranging
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foodigit computational food science and digital transformation era chair programme
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the eu agrifood industry is facing major challenges related to food security safety and sustainability european ri actors can significantly contribute to addressing these challenges and support competiveness of eu food sector the aristotle university of thessaloniki auth the largest university in greece is widely recognised as an excellent food science ri centre a swot analysis reveals that due to the fragmentation of food research across different schools the huge ri potential of auth is not yet fully exploited hampering progress in research excellence and talent attractiveness in line with the new era for research and innovation the european green deal and the eu4digital strategy at the heart of this proposal is the ambitious vision to establish the computational food science and digital transformation foodigit centre at auth under the guidance of a distinguished era chair foodigit aims to bridge food science across auth and ri excellence by integrating current food research with data science cuttingedge digital tools and information technology it solutions this integration will attract toptier talents and act as a transformative force boosting research and infrastructure synergy across auth the foodigit centre is also poised to be a cornerstone for reshaping the relationship between academia and society through the creation of foodigiteco a new innovation and knowledge transfer ecosystem based on an extensive partnership network with ri organisations food industry federations regulatorscompetent authorities and consumer associations foodigiteco will transfer cuttingedge research results and knowledge from academia to the food industry but also act as a conduit for industry needs identifying challenges and requirements directly from the food sector and integrating them into auths education programme overall foodigit will enhance auths visibility and competitiveness in the european research area
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preventing groundwater contamination related to global and climate chanpreventing groundwater contamination related to global and climate change through a holistic approach on managed aquifer recharge
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the impact climate and global change cc and gc is endangering human health food security and biodiversity urgent action is needed to achieve 2030 zero pollution goalsmar2protect will provide a holistic approach to prevent groundwater gw contamination from gc and cc impacts based on a newgeneration managed aquifer recharge mar the core of the innovative mar is the mair dss that will incorporate technological and societal engagement information using an aibased evaluation to improve gw quality to ensure a high replication potential mair dss will collect information from 5 demo sites in eu pt it es nl and 2 in noneu countries tn za which were carefully chosen by their degree of maturity from previous successful projects and a wide range of settings in terms of climatic conditions water sources type of pollution mar scheme and politicalsocietal context all technologies will be tested and validated until trl5 mar2protect will ensure a strong engagement of civil society in gw prevention actions up to a srl equal to 6 the project will involve national and eu policy makers that in collaboration with a community of practice formed by worldwide experts will guarantee the strengthening eu policy for the prevention of gw contaminationthanks to its holistic approach and to the high replicability of its results mar2protect will lead to a marked enhancement in gw protection across the eu and beyond and to the generation of knowledge for the transition to a sustainable water management the consortium includes 8 partners and 1 affiliated entity from 6 different eucountries and switzerland and 2 international partners from tunisia and south africa 2 universities unibo ktu 7 rtos novacoo ciimar cetand aqua ihe it issbat suwi and 1 association feuga in addition the inclusion of 3 large water utilities as associated partners and a policy maker from za will lead to a relevant enhancement of the project impact
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new isotope tracers of rocky planet forming environments
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the plethora of earthlike exoplanets indicate that planetformation is efficient highlighting the need for unravelling the pathways to forming habitable worlds the new planetformation paradigm ie pebble accretion suggests that mmtocm sized pebbles are the main planetary building blocks as opposed to colliding protoplanetary bodies bulk samples of meteorites from asteroids leftovers from the early solar system have been long used to infer the nature of earths precursor material however pebble accretion predicts that pebblelike components of primitive chondrite meteorites provide a more accurate record of the precursor material to terrestrial planets including the source of volatiles critical to life the most abundant chondrite constituents are mmsized chondrules hypothesized to be the pebbles driving planet formation chondrules formed within 5 myr of the solar system thus represent timesequenced samples that can probe the nature of the matter including its environments that accreted to rocky planets we will elucidate the origin and history of the matter precursor to terrestrial planets by studying chondrules matrix and refractory components in chondrites this information is key for understanding the initial conditions allowing the formation of earthlike planets combining isotope fingerprinting agedating and petrology our data will be obtained using stateoftheart techniques including next generation collision cell and thermal ionization mass spectrometry as well as highresolution imaging we will identify the precursor matter to terrestrial planets and probe how its composition varied in space and time identify the disk environment where the primordial population of planetesimals seeds formed and evaluate the role of thermal processing and outward recycling in modifying inner disk matter with these goals including highrisk highgain ventures we are in a strong position to make step change discoveries in cosmochemistry
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enhancing efficiency and effectiveness in education
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highquality education is a key driver of economic growth and social progress despite large investments in education over the past few decades the quality of education in some eu countries has stagnated or even deteriorated marginalized populations are particularly vulnerable to the negative consequences arising from inadequate educational policies understanding the efficiency and costeffectiveness of investment in quality education is crucial for allocating resources to where they could have the largest economic and social impacts the effect research project has been established as an impactdriven initiative that aims to provide evidencebased policy recommendations to improve the quality of education by investigating the effectiveness and efficiency of education systems and specific policies in eu countries by using quasiexperimental evidence effect advances knowledge in several critical areas including diversity equity and inclusion teachers trainers and digital transition instruction and adultlearning effect has four interrelated objectives objective 1 offers novel insights on diversity equity and inclusion by investigating targeted programs for disadvantaged students as well as religious and elite schools objective 2 investigates how teacher shortages can be mitigated and examines the role of digital environments objective 3 evaluates policies related to instruction admission standards and upskilling and reskilling of adults finally objective 4 analyzes how the efficiency of eu educational systems has changed since the covid19 pandemic and establishes the main policy levers and qualitative insights that may explain efficiency changes effect brings together a multidisciplinary research team of economists sociologists neuropsychologists teacher trainers education scientists mathematicians and sustainability and operational research experts from four european research universities a research institute and a ngo
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proteomewide functional interrogation and modulation of gut microbiome species
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the gut microbiome plays a key role in human health genomics approaches excel at cataloguing species composition and associating imbalances with disease yet as we are oblivious to the function of a large proportion of proteins of these organisms we are limited in our understanding of the molecular mechanisms that drive disease or promote health in this groundbreaking project we will systematically identify the function and interactions of proteins of microbiome species deliver compounds to modulate them and develop strategies to rationally manipulate microbiome compositionwe will use a scalable systems biology approach based on highthroughput proteomics using more than 100 drugs to perturb the proteome of a panel of 38 prevalent and phylogenetically diverse bacterial species that colonize the human gut proteins involved in the same biological process have coordinated changes in their levels across perturbations allowing us to infer function based on annotated proteins we will further assess which proteins are likely to physically interact as they coaggregate upon heatinduced denaturation leading to a map of the functional protein network of these species we will then identify the mechanisms of action and resistance of the used drugs by using thermal proteome profiling and by measuring intracellular drug concentrations this will allow us to identify species that encode the target but no resistance elements so we can use the information to specifically deplete diseaseassociated species from microbial communities these strategies extend beyond the strains studied in this project as homologs of these proteins can be identified solely from genome sequencesoverall this project paves the way for the microbiome field to move from associations to targetable mechanisms with a vision to design therapies with reduced side effects to restore the microbiome to a healthy state
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fast yet accurate routine rational design of novel enzymes
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life could not be sustained without the presence of enzymes which are responsible for accelerating the chemical reactions in a biologically compatible timescale enzymes present other advantageous features such as high specificity and selectivity plus they operate under very mild biological conditions inspired by these extraordinary characteristics many scientists wondered about the possibility of designing new enzymes for industriallyrelevant targets unfortunately none of the current enzyme design strategies is able to rapidly design tailormade enzymes at a reduced cost this is limiting the general routine application of enzyme catalysis in industry and thus the chemical manufacturing competitiveness the goal of this project is to develop a fast yet accurate computational enzyme design approach for allowing the routine design of highly efficient enzymes fasten combines computational chemistry deep learning graph theory and computational geometry for controlling the complexity of enzyme catalysis in a new computational protocol that will capture the chemical steps and conformational changes that take place along the catalytic itinerary active site and distal activityenhancing mutations are predicted based on correlation and coevolutionarybased guidelines and the catalytic potential of the new designs is estimated by means of geometrybased oracles this new computational approach will be validated with the design of enzymes presenting complex conformational dynamics and multistep mechanisms the experimental evaluation of many of the designs will finally reveal the potential of this new approach for the fast routinely design of industriallyrelevant enzymes fasten has the potential of making the routine design of enzymes possible thus improving our current lives and leading to a more sustainable world for our generations
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aibased longterm health risk evaluation for driving behaviour change strategies in children and youth
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noncommunicable diseases ncds are the leading cause of death and healthcare expense common risk factors for many of them are obesity and low physical fitness resulting from an unhealthy lifestyle targeting children and youth for lifestyle interventions has been suggested because 1 early precursors of most ncds are already present at this age 2 childhood and adolescence are critical periods for the acquisition of healthy lifestyle habits and 3 unhealthy lifestyle in this age group is prevalentwe propose to develop longterm riskprediction models for cardiovascular and metabolic disease for people aged 519 we have already identified 15 datasets with data on behaviour fitness biomarkers and actual ncds spanning various ages we will develop machinelearning methods that can train models on such heterogeneous datasets enabling the prediction of risk for people of various ages for whom different data is available we will employ federated learning for data privacy carefully curate and balance the data to ensure it is biasfree and representative of the target group and employ methods for explanation and visualisation of the data models and predictions participatory design involving explanation of the ai will be used to design two applications one for health professionals and the other for citizens both will show the risks broken down by risk factors and the recommended behaviour changes to reduce them in a manner appropriate for each user group the developed solution will be validated in a large proofofconcept study in four countries involving different health settings family school primary care integrated care to facilitate practical use of the developed solution we will prepare recommendations for their implementation and a realistic exploitation plan these activities will be supported by dissemination and communication activities specifically tailored to the target groups eg involving science museums
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innovative storage technology and operations in hydropower
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storhy aims to minimize capex opex for innovative pumped storage projects this is achieved by enhancing the lifetime and recyclability of components and equipment and devising operation strategies for unconventional schemes through sensorbased condition monitoring systems these systems detect early failure mechanisms enabling the postponement of unnecessary maintenance actions and avoiding unplanned outages furthermore strategic use of digital tools for operational management is employed to improve efficiency reliability and availability of pumped storage plantsconsidering energy and market demand dynamics variable renewable generation and integration storhy addresses climate change effects and enhances flexibility and resilience of the eu energy grid the project focuses on optimizing plant availability offering increased storage potential peak shaving fast response regulation and ancillary services for grid resilience the integration of digital tools realtime controllers monitoring strategies and predictive maintenance algorithms is consolidated in a cyberphysical platform for advanced decision support cads this platform along with hightech computational models enables the realistic estimation of critical component degradation in short and longterm operations this information supports informed decisionmaking in psp operation and aids in the design of innovative control strategies for challenging conditionsthese developments result in a broader operating range and increased flexibility in eu hydropower generation and storage potentialstorhy prioritizes building regional connections with local stakeholders industry academia and policy institutions sustainability considerations encompass environmental circularity economic and social aspects drawing insights from previous projects these insights include onsite impacts societal acceptance ecological concerns and lcc
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metalinduced energy transfer based electrometry and nanometry dissecting electrostatic phenomena in biological processes
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almost all biological processes involving molecular trafficking signaltransduction celltocell interactions hinge on precisely orchestrated electrostatic interactions arising from electrical charges on biomolecules and membranes yet our understanding of the role of electrostatics in these fundamental processes remains elusive due to the absence of quantitative methods to measure the electrical charges of biomolecules and to map the surface charge distribution of membranes this challenge is further compounded by the requirement of capturing molecular and membrane dynamics that take place at the nanometre length scales and nano to submillisecond time scales the overall objective of this project is to bridge this technological gap by introducing metalinduced energy transfer based electrometry and nanometry mieten a groundbreaking technology that will quantify the electrical charge of biomolecules or membranes while capturing their dynamics with nanometre spatial and microsecond temporal resolutions we will demonstrate mieten for measuring i the charges and sizes of individual membrane proteins ii membrane protein structural changes conformational dynamics and spatial organization in response to changes in membrane potential iii reactiondiffusion kinetics at a charged membrane iv mechanical properties and dynamics of membranes containing charged inclusions and v interactions between two charged membranes the ability to measure biomolecular and membrane electrical charges and to elucidate the role of electrostatics in structure organization and interactions of proteins as well as in membrane dynamics and intermembrane interactions will be crucial for our understanding of fundamental biology and for advancing biomedical research mieten will open new frontiers in studying protein and membrane dynamics and impact drug development early diagnostics and therapeutic interventions
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building green and climate neutral cityhubs
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climaborough is an innovation project designed to field test the climhub climate sandbox and climate service concepts within 12 european cities engaged in their ecological and digital transition the project aims to enhance traditional urban and spatial planning approaches through data and knowledge based decision making including a possible new role for gis geographic information systems including climate services coproduction for transitions crosscity and crosscountry pilot cocreation as well as the tactical use of public procurement of innovative solutions the goal is not just to enhance an open set of tools leveraging climate transition in cities but also to boost the exchange of experimental good practices experiences and lessons learnt in this field to help cities meet climate neutrality by 2050 this will be achieved by the following expected results a building climhubs of cities and solution providers to work on experimentations in real conditions b harnessing the collective intelligence of local stakeholders for collaborative solution development c defining climate services as a model strategy to use data and visualisation tools for climate transition d field testing the climate sandbox concept as a way to prioritise and facilitate transformation of successfully deployed prototypes into established solutions for climate adaptation and mitigation in cities and e monitoring and assessing the progress in achieving those goals and in implementing a climate neutrality planning scheme based on the lessons learnt and successful concept of the h2020 designscapes csa climaborough has the ambition to bridge the gap between design and implementation of urban innovations particularly in the domain of climate change adaptation and mitigation
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